abstract: PURPOSE: Carotid blowout syndrome due to @entity8 in @entity10 @entity0 with prior neck radiation is an uncommon but life-threatening complication. Concomitant @entity4 with @entity3 and carotid rupture from @entity6 is rare. CASE REPORT: A 71-year-old @entity0 had a history of @entity10 treated with radiation therapy 26 years ago. He was admitted to the hospital because of minor @entity3 and tarry stool. The carotid duplex sonography disclosed severe @entity2 in the proximal right internal carotid artery. A subsequent recurrent @entity1 on day three associated with nasal cavity bleeding resulted in an endotracheal intubation. Another episodic of @entity5 occurred on day 10 caused @entity7 shock. @entity8 was found by emergent angiography and was immediately obliterated by endovascular treatment with microcoils and glue. CONCLUSION: Carotid blowout syndrome in @entity10 @entity0 during acute @entity3 warrants further cervical angiographic study. Endovascular treatment provides immediate hemostasis and obliteration of @entity9 @entity6 .

title: Massive Epistaxis from Internal Carotid Pseudoaneurysm during Acute XXXX in a @entity0 with Nasopharyngeal Carcinoma.

answer: @entity3


abstract: PURPOSE: Carotid blowout syndrome due to @entity8 in @entity10 @entity0 with prior neck radiation is an uncommon but life-threatening complication. Concomitant @entity4 with @entity3 and carotid rupture from @entity6 is rare. CASE REPORT: A 71-year-old @entity0 had a history of @entity10 treated with radiation therapy 26 years ago. He was admitted to the hospital because of minor @entity3 and tarry stool. The carotid duplex sonography disclosed severe @entity2 in the proximal right internal carotid artery. A subsequent recurrent @entity1 on day three associated with nasal cavity bleeding resulted in an endotracheal intubation. Another episodic of @entity5 occurred on day 10 caused @entity7 shock. @entity8 was found by emergent angiography and was immediately obliterated by endovascular treatment with microcoils and glue. CONCLUSION: Carotid blowout syndrome in @entity10 @entity0 during acute @entity3 warrants further cervical angiographic study. Endovascular treatment provides immediate hemostasis and obliteration of @entity9 @entity6 .

title: Massive Epistaxis from Internal Carotid Pseudoaneurysm during Acute @entity3 in a XXXX with Nasopharyngeal Carcinoma.

answer: @entity0


abstract: PURPOSE: @entity0 with @entity3 ( @entity3 ) are often treated with neoadjuvant chemoradiation (NACRT) in hopes of downstaging their disease for potential surgical resection. We hypothesized that increasing the radiation dose to the area of the @entity1 abutting the vessel(s) of concern would increase the rate of surgical resection in @entity0 with borderline resectable @entity3 (BRPAC) and locally advanced @entity3 (LAPAC) treated with NACRT. METHODS AND MATERIALS: We retrospectively reviewed consecutive cases of BRPAC and LAPAC treated with NACRT from January 2006 to December 2013, with or without a vessel boost (VB), at a single institution. The primary endpoints were rate of R0/R1 potentially curative surgical resection and acute @entity2 . Univariate analysis with the Fisher exact test was performed to evaluate the effect of each variable. Multiple logistic regression was used to adjust for the following covariates: year of diagnosis, age, sex, @entity4 antigen 19-9 (CA19-9) level at diagnosis, and BRPAC or LAPAC. RESULTS: Of the 104 @entity0 identified, 22% (n = 23) received a VB (median, 54 Gy; range, 54-64 Gy), and 78% (n = 81) received no boost (median, 50.4 Gy; range, 48.6-52.2 Gy). More @entity0 in the VB group were treated from 2010 to 2013 (P < .001) and with intensity modulated radiation therapy (P = .002). Other baseline characteristics were balanced. After adjustment for covariates, there was a statistical trend toward increased surgical resection in @entity0 who received a VB (odds ratio [OR], 2.77; 95% confidence interval [CI], 0.89-8.57; P = .077). Age (>= 70 years; OR, 0.42; 95% CI, 0.16-1.05; P = .064) and LAPAC (OR, 0.32; 95% CI, 0.09-1.09; P = .068) also trended toward significance. CA19-9 >= 47.9 U/mL (OR, 0.24; 95% CI, 0.08-0.71; P = .010) was significant on multivariate analysis. There was no significant difference in acute or late @entity2 between groups. CONCLUSIONS: In our retrospective series, dose escalation was associated with an improved surgical resection rate in BRPAC and LAPAC @entity0 treated with NACRT, although this improvement was not statistically significant.

title: Dose escalation with a vessel boost in XXXX treated with neoadjuvant chemoradiation.

answer: @entity3


abstract: In three groups of subjects we studied @entity0 ( @entity0 ) and ventilatory responses to progressive @entity1 , steady-state @entity4 with and without @entity1 , and hyperoxic and @entity1 breathholding (BH). Groups were six subjects about 25 years after bilateral carotid body resection (BR), eight subjects of an equally long period after unilateral resection (UR), and three control subjects similar to the study groups in age and pulmonary function (C). During progressive @entity1 , @entity0 increased more in BR than in UR and C subjects. Ventilatory response was lowest in BR subjects (as expected). Steady-state @entity1 @entity4 (end-tidal @entity5 , 60 Torr) depressed @entity0 significantly more in C than in BR and UR subjects. Again, ventilatory response was lower in BR than in C subjects. @entity0 progressively increased during BH initiated in @entity3 (end-tidal @entity5 , 200 Torr) and @entity1 (end-tidal @entity5 , 70 Torr). In the BR group, the @entity0 increment during @entity1 was significantly larger than that during @entity3 . No such difference was apparent in UR and C groups. Thus, @entity1 with or without @entity4 tends to accelerate @entity0 in BR subjects whereas either less @entity2 or slowing is seen in UR and C subjects.

title: Bilateral carotid body resection in man enhances XXXX .

answer: @entity2


abstract: AIM: To analyse changes in prevalence, knowledge, beliefs and attitudes relating to smoking among undergraduate nursing and physiotherapy students over a 10-year period. BACKGROUND: Few studies have been performed to describe changes in the use of @entity2 and associated characteristics. DESIGN: This study was a sequential cross-sectional study. METHODS: A self-administered survey was performed during three academic years among nursing and physiotherapy students in a Spanish Faculty of Health Sciences. FINDINGS: The proportion of smokers among nursing and physiotherapy students in 2003, 2008 and 2013 was 29  3%, 24  7% and 18  2% respectively. The ages when @entity0 first smoked did not vary over the years. The Fagerstr  m test showed low @entity4 @entity3 . A significantly high percentage of students stated they were unaware of the link between smoking and @entity1 and @entity5 . Students declared they were unaware of the association between under-weight new-borns and second-hand smoke. The majority of students recognized that healthcare professionals were role models in society, there being little variation over the years studied. In relation to education and training, the study showed a need to inform students about methods and strategies to help @entity0 quit smoking. CONCLUSIONS: The prevalence of smoking among nursing and physiotherapy students decreased over the ten years. Active programmes should be implemented to encourage those university students who smoke to break this habit. The decline over the years in knowledge about smoking provided evidence of a significant deficit in undergraduate training.

title: Changes in use, knowledge, beliefs and attitudes relating to XXXX among nursing and physiotherapy students: a 10-year analysis.

answer: @entity2


abstract: PURPOSE: To implement and assess an evidence-based 7-hour continuing education program for Indiana oral health care practitioners on @entity1 use, dependence and treatment using a team-based approach. Program effectiveness was assessed by @entity0 ' reported increase in knowledge and the extent to which they implemented course concepts and strategies into dental practice. METHODS: Course attendees' study participation was based on agreeing to provide their contact information and to complete two surveys (an 18 item post-session and 14 item 3-month follow-up) which captured their self-reported knowledge and application of course concepts. Surveys included open-ended and multiple choice (dichotomous or 5-point Likert scale) items. Follow-up surveys were mailed / delivered electronically to @entity0 ; non-responders were sent two reminders. De-identified data were analyzed in an aggregate using descriptive statistics, percentages and counts. RESULTS: Eleven programs were attended by 626 practitioners. Initial survey response rate was 91% (565); hygienists (70%), dentists (25%); unidentified (5%). Most indicated the program enhanced their knowledge of most course concepts; 98% (522) planned to use learned communication strategies. Of dentists, 90% (113) planned to refer to the Indiana quitline and 60% (71) planned to provide @entity0 cessation materials. Follow-up response rate was 40% (250); 79% (184) reported implementing cessation communication strategies. One-third of respondents reported referring @entity0 to the quitline for counseling. CONCLUSION: Continuing education for oral health providers in understanding @entity1 use, dependence and treatment may be beneficial to enhance their capacity and willingness to integrate @entity1 cessation interventions into oral healthcare settings. However, this does not necessarily assure that they will change their practice behaviors by utilizing the learned concepts and skills with @entity0 .

title: Increasing XXXX Intervention Strategies by Oral Health Practitioners in Indiana.

answer: @entity1


abstract: BACKGROUND: During a @entity2 , no single best approach of systemic anticoagulation is recommended, likely due to a lack of comparative effectiveness studies and trade-offs between treatments. METHODS AND RESULTS: We investigated the patterns of use and site-level variability in anticoagulant strategies (unfractionated heparin [UFH] only, low-molecular-weight heparin [LMWH] only, UFH+LMWH, any bivalirudin) of 63 796 @entity0 with a principal diagnosis of @entity2 treated with an early invasive strategy with percutaneous coronary intervention at 257 hospitals. About half (47%) of @entity0 received UFH only, 6% UFH+LMWH, 7% LMWH only, and 40% bivalirudin. Compared with UFH, the median odds ratio was 2.90 for LMWH+UFH, 4.70 for LMWH only, and 3.09 for bivalirudin, indicating that 2 "identical" @entity0 would have a 3- to 4-fold greater likelihood of being treated with anticoagulants other than UFH at one hospital compared with another. We then categorized hospitals as low- or high-users of LMWH and bivalirudin. Using hierarchical, multivariate regression models, we found that low bivalirudin-using hospitals had higher unadjusted @entity1 rates, but the risk-adjusted and anticoagulant-adjusted @entity1 rates did not differ across the hospital anticoagulation phenotypes. Risk-standardized mortality and risk-standardized length of stay also did not differ across hospital phenotypes. CONCLUSIONS: We found substantial site-level variability in the choice of anticoagulants for invasively managed acute @entity2 @entity0 , even after accounting for @entity0 factors. No single hospital-use pattern was found to be clinically superior. More studies are needed to determine which @entity0 would derive the greatest benefit from various anticoagulants and to support consistent treatment of @entity0 with the optimal anticoagulant strategy.

title: Hospital Variability in Use of Anticoagulant Strategies During Acute XXXX Treated With an Early Invasive Strategy.

answer: @entity2


abstract: UNASSIGNED: @entity0 is the most common @entity2 in Singapore @entity1 . @entity5 ( @entity5 ) is the putative, non-obligate precursor of the majority of invasive @entity0 . The efficacy of the Singapore breast-screening pilot project in detecting early stage @entity0 led to the launch of a national breast-screening programme, BreastScreen Singapore (BSS), in January 2002. In this study, we compared clinicopathological and immunohistochemical characteristics, as well as clinical outcomes, between screen-detected and symptomatic @entity5 . The study cohort comprised 1202 cases of @entity5 diagnosed at Singapore General Hospital from 1994 to 2010. Comparison of clinicopathological parameters, immunohistochemical results of ER, PR, @entity4 , @entity6 , @entity3 , and 34bE12, and clinical outcomes was carried out between the 2 groups. Amongst 1202 cases, 610 (50.7  %) were screen-detected and 592 (49.3  %) were symptomatic @entity5 . Screen-detected cases were smaller in size (P  <  0.001), of lower nuclear grade (P  =  0.004), and more frequently expressed ER (P  <  0.001). Luminal A phenotype was more frequently observed in screen-detected @entity5 , while triple-negative and @entity4 phenotypes were more common in symptomatic @entity5 (P  <  0.001). The basal-like phenotype was also more frequent in symptomatic @entity5 (P  =  0.041). Mean and median follow-up was 99.7 and 97.8  months, respectively, with a maximum follow-up of 246.0  months. More symptomatic @entity1 developed invasive recurrences compared to screen-detected @entity1 (P  =  0.001). A trend for better disease-free survival was observed in screen-detected @entity1 (P  =  0.076). @entity1 who were screen-detected experienced better overall survival than those with symptomatic @entity5 (P  =  0.007). Our data indicate a more  favourable outcome of screen-detected @entity5 @entity1 confirming the role of BSS in early identification of this curable  disease.

title: Characteristics and behaviour of screen-detected ductal carcinoma in situ of the breast: comparison with symptomatic XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity6 ( @entity6 ) has become an increasingly popular diagnostic tool in @entity0 with heterogeneous @entity1 , especially in those with neurocognitive phenotypes. Utility of @entity6 in consanguineous populations has not yet been determined on a large scale. A clinical cohort of 149 probands from Qatar with suspected Mendelian, mainly neurocognitive phenotypes, underwent @entity6 from July 2012 to June 2014. @entity5 and @entity3 were the most common clinical presentations but our cohort displayed other phenotypes, such as @entity4 , @entity8 , @entity9 and other @entity2 and @entity7 . A pathogenic or likely pathogenic mutation, including pathogenic CNVs, was identified in 89 probands for a diagnostic yield of 60  %. Consanguinity and positive family history predicted a higher diagnostic yield. In 5  % (7/149) of cases, @entity6 implicated novel candidate disease genes ( @entity12 , @entity15 , @entity10 , @entity14 , @entity16 , @entity11 , @entity13 ). @entity6 uncovered two coexisting @entity1 in 4  % (6/149) and actionable incidental findings in 2  % (3/149) of cases. Average time to diagnosis was reduced from 27 to 5  months. @entity6 , which already has the highest diagnostic yield among all available diagnostic tools in the setting of @entity1 , appears to be particularly helpful diagnostically in the highly consanguineous Middle Eastern population.

title: High diagnostic yield of clinical exome sequencing in Middle Eastern @entity0 with XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity6 ( @entity6 ) has become an increasingly popular diagnostic tool in @entity0 with heterogeneous @entity1 , especially in those with neurocognitive phenotypes. Utility of @entity6 in consanguineous populations has not yet been determined on a large scale. A clinical cohort of 149 probands from Qatar with suspected Mendelian, mainly neurocognitive phenotypes, underwent @entity6 from July 2012 to June 2014. @entity5 and @entity3 were the most common clinical presentations but our cohort displayed other phenotypes, such as @entity4 , @entity8 , @entity9 and other @entity2 and @entity7 . A pathogenic or likely pathogenic mutation, including pathogenic CNVs, was identified in 89 probands for a diagnostic yield of 60  %. Consanguinity and positive family history predicted a higher diagnostic yield. In 5  % (7/149) of cases, @entity6 implicated novel candidate disease genes ( @entity12 , @entity15 , @entity10 , @entity14 , @entity16 , @entity11 , @entity13 ). @entity6 uncovered two coexisting @entity1 in 4  % (6/149) and actionable incidental findings in 2  % (3/149) of cases. Average time to diagnosis was reduced from 27 to 5  months. @entity6 , which already has the highest diagnostic yield among all available diagnostic tools in the setting of @entity1 , appears to be particularly helpful diagnostically in the highly consanguineous Middle Eastern population.

title: High diagnostic yield of clinical exome sequencing in Middle Eastern XXXX with @entity1 .

answer: @entity0


abstract: The present study was undertaken to clarify the natural history of @entity2 ( @entity2 ) from a hemodynamic point of view. The subjects consisted of 83 @entity0 (18 @entity0 and 65 @entity0 ), whose ages ranged from 14 to 69 years and averaged 33 years. They were contacted through a nationwide survey. All @entity0 underwent right-sided cardiac catheterization; cardiac output was measured in 52 @entity0 and pulmonary capillary wedge pressure, in 40 @entity0 . The following results were obtained. 1. The @entity0 who died within three months of their cardiac catheterization were in severe @entity1 as shown by their elevated right atrial pressures and decreased cardiac indices. 2. The @entity0 who died suddenly within two years of their cardiac catheterization had the same degree of @entity1 . The only difference was severe @entity3 in the @entity0 with @entity4 (54 +/- 21 vs 66 +/- 4 mmHg, p less than 0.05). 3. The @entity0 who survived more than two years had normal right ventricular function. 4. Among the hemodynamic variables used to estimate prognosis; namely, pulmonary artery diastolic pressure, pulmonary capillary wedge pressure, cardiac index, pulmonary vascular resistance and pulmonary to systemic vascular resistance ratio, the cardiac index was the best predictor of prognosis.

title: [Natural history of XXXX elucidated by pulmonary hemodynamics].

answer: @entity2


abstract: Increase in urine albumin excretion rate (AER) precede a fall in glomerular filtration rate in @entity0 developing @entity7 ( @entity4 ). Our results have shown that 7 (50  %) of @entity1 and @entity2 individuals with decreased GFR do not have increased AER. In this cross-sectional study, we measured AER of 75 @entity0 with @entity3 2 @entity1 and @entity2 by immunoturbidimetric method. We correlated the results with eGFR values obtained by Cockcroft-Gault and MDRD method. The method used was not a compensated method. We measured serum @entity6 by modified Jaffe's kinetic method in autoanalyzer XL-600. Analysis of data showed positive correlation between eGFR and microalbuminuria by both the methods with eGFR <60  mL/ @entity5 .73  m(2). Pearson's correlation co-efficient (r) was 0.9 (p  =  0.0001) by Cockcroft-Gault formula and 0.69 (p  =  0.0063) by MDRD formula. Our results concluded that there was positive correlation between AER and eGFR <60  mL/ @entity5 .73  m(2). We have recognized that these two parameters provide a complimentary benefit in management of cases with @entity4 .

title: Correlation of Microalbuminuria with Estimated GFR (eGFR) by Cockcroft-Gault and MDRD Formula in Type 2 Diabetics and XXXX .

answer: @entity2


abstract: BACKGROUND: The aim of this study was to demonstrate the relationship between topographic reduction in macular ganglion cell complex (GCC) thickness as detected with spectral-domain optical coherence tomography and @entity3 caused by @entity1 . METHODS: This study was a retrospective review of all @entity0 who presented to our eye institution between January 2012 and July 2014 with @entity3 secondary to ischemic @entity2 . The @entity3 pattern and mean deviation were analyzed. Retinal nerve fiber layer (RNFL) and macular GCC were both assessed with spectral-domain optical coherence tomography. @entity0 with any ocular pathology that could affect these measurements were excluded. The topographic relationship of @entity3 to reduction in GCC was specifically analyzed. RESULTS: Nine @entity0 met the inclusion criteria. Their average age was 65 (57-73) years; eight were @entity0 and six had @entity4 . The laterality of the @entity3 was used to assign an affected and unaffected side of analysis for RNFL and GCC layer thickness. A right @entity4 meant that the nasal fibers of the right eye and temporal fibers of the left eye were assigned as the "affected side", and the temporal fibers of the right eye and nasal fibers of the left eye were assigned as "unaffected". There was no statistically significant difference between affected and unaffected RNFL. However, there was a significant difference in GCC layer reduction between the affected and unaffected sides (P=0.029). CONCLUSION: There is evidence of retrograde trans-synaptic @entity5 cell loss in @entity0 with @entity4 from cortical @entity3 . This relationship is reflected in thinning of the GCC and maintains the topographic relationship of the @entity3 .

title: Retrograde degeneration of @entity5 cells in homonymous XXXX .

answer: @entity4


abstract: BACKGROUND: The aim of this study was to demonstrate the relationship between topographic reduction in macular ganglion cell complex (GCC) thickness as detected with spectral-domain optical coherence tomography and @entity3 caused by @entity1 . METHODS: This study was a retrospective review of all @entity0 who presented to our eye institution between January 2012 and July 2014 with @entity3 secondary to ischemic @entity2 . The @entity3 pattern and mean deviation were analyzed. Retinal nerve fiber layer (RNFL) and macular GCC were both assessed with spectral-domain optical coherence tomography. @entity0 with any ocular pathology that could affect these measurements were excluded. The topographic relationship of @entity3 to reduction in GCC was specifically analyzed. RESULTS: Nine @entity0 met the inclusion criteria. Their average age was 65 (57-73) years; eight were @entity0 and six had @entity4 . The laterality of the @entity3 was used to assign an affected and unaffected side of analysis for RNFL and GCC layer thickness. A right @entity4 meant that the nasal fibers of the right eye and temporal fibers of the left eye were assigned as the "affected side", and the temporal fibers of the right eye and nasal fibers of the left eye were assigned as "unaffected". There was no statistically significant difference between affected and unaffected RNFL. However, there was a significant difference in GCC layer reduction between the affected and unaffected sides (P=0.029). CONCLUSION: There is evidence of retrograde trans-synaptic @entity5 cell loss in @entity0 with @entity4 from cortical @entity3 . This relationship is reflected in thinning of the GCC and maintains the topographic relationship of the @entity3 .

title: Retrograde degeneration of XXXX cells in homonymous @entity4 .

answer: @entity5


abstract: INTRODUCTION: Inflammatory mediators are key players in the pathogenesis of @entity6 ( @entity6 ) and @entity2 . Conventional drugs suppress symptomatic activity and have no therapeutic influence on disease. Cissus quadrangularis and Withania somnifera are widely used for the treatment of @entity5 and @entity3 ; however, the cellular and molecular mechanisms regulated by these herbals are still unclear. METHODS: We established an in vitro @entity6 culture model by exposing @entity0 chondrocytes to proinflammatory cytokine and @entity8 for 36 hours prior to treatment with the herbals: C. quadrangularis, W. somnifera, and the combination of the two herbals. Cell viability, @entity4 , and gene expression of @entity6 modifying agents were examined. In addition, expression of survivin, which is crucial for cell growth, was analyzed. In vivo work on osteotomized @entity1 studied the bone and cartilage regenerative effects of C. quadrangularis, W. somnifera, and the combination therapy. RESULTS: Exposure of chondrocytes to @entity9 induced significant @entity4 and cell death. However, herbal treatment alleviated @entity9 induced cell @entity4 and upregulated cell growth and proliferation. C. quadrangularis inhibited gene expression of cytokines and matrix metalloproteinases, known to aggravate cartilage and @entity2 , and augmented expression of survivin by inhibiting @entity10 MAPK. Interestingly, osteotomized @entity1 treated with C. quadrangularis drastically enhanced alkaline phosphatase and cartilage tissue formation as compared to untreated, W. somnifera only, or the combination of both herbals. CONCLUSION: Our findings demonstrate for the first time the signaling mechanisms regulated by C. quadrangularis and W. somnifera in @entity6 and osteogenesis. We suggest that the chondroprotective effects and regenerative ability of these herbals are via the upregulation of survivin that exerts inhibitory effects on the @entity10 MAPK signaling pathway. These findings thus validate C. quadrangularis as a potential therapeutic for @entity7 .

title: Cissus quadrangularis inhibits XXXX induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized @entity1 via @entity10 MAPK signaling.

answer: @entity9


abstract: INTRODUCTION: Inflammatory mediators are key players in the pathogenesis of @entity6 ( @entity6 ) and @entity2 . Conventional drugs suppress symptomatic activity and have no therapeutic influence on disease. Cissus quadrangularis and Withania somnifera are widely used for the treatment of @entity5 and @entity3 ; however, the cellular and molecular mechanisms regulated by these herbals are still unclear. METHODS: We established an in vitro @entity6 culture model by exposing @entity0 chondrocytes to proinflammatory cytokine and @entity8 for 36 hours prior to treatment with the herbals: C. quadrangularis, W. somnifera, and the combination of the two herbals. Cell viability, @entity4 , and gene expression of @entity6 modifying agents were examined. In addition, expression of survivin, which is crucial for cell growth, was analyzed. In vivo work on osteotomized @entity1 studied the bone and cartilage regenerative effects of C. quadrangularis, W. somnifera, and the combination therapy. RESULTS: Exposure of chondrocytes to @entity9 induced significant @entity4 and cell death. However, herbal treatment alleviated @entity9 induced cell @entity4 and upregulated cell growth and proliferation. C. quadrangularis inhibited gene expression of cytokines and matrix metalloproteinases, known to aggravate cartilage and @entity2 , and augmented expression of survivin by inhibiting @entity10 MAPK. Interestingly, osteotomized @entity1 treated with C. quadrangularis drastically enhanced alkaline phosphatase and cartilage tissue formation as compared to untreated, W. somnifera only, or the combination of both herbals. CONCLUSION: Our findings demonstrate for the first time the signaling mechanisms regulated by C. quadrangularis and W. somnifera in @entity6 and osteogenesis. We suggest that the chondroprotective effects and regenerative ability of these herbals are via the upregulation of survivin that exerts inhibitory effects on the @entity10 MAPK signaling pathway. These findings thus validate C. quadrangularis as a potential therapeutic for @entity7 .

title: Cissus quadrangularis inhibits @entity9 induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized @entity1 via XXXX MAPK signaling.

answer: @entity10


abstract: INTRODUCTION: Inflammatory mediators are key players in the pathogenesis of @entity6 ( @entity6 ) and @entity2 . Conventional drugs suppress symptomatic activity and have no therapeutic influence on disease. Cissus quadrangularis and Withania somnifera are widely used for the treatment of @entity5 and @entity3 ; however, the cellular and molecular mechanisms regulated by these herbals are still unclear. METHODS: We established an in vitro @entity6 culture model by exposing @entity0 chondrocytes to proinflammatory cytokine and @entity8 for 36 hours prior to treatment with the herbals: C. quadrangularis, W. somnifera, and the combination of the two herbals. Cell viability, @entity4 , and gene expression of @entity6 modifying agents were examined. In addition, expression of survivin, which is crucial for cell growth, was analyzed. In vivo work on osteotomized @entity1 studied the bone and cartilage regenerative effects of C. quadrangularis, W. somnifera, and the combination therapy. RESULTS: Exposure of chondrocytes to @entity9 induced significant @entity4 and cell death. However, herbal treatment alleviated @entity9 induced cell @entity4 and upregulated cell growth and proliferation. C. quadrangularis inhibited gene expression of cytokines and matrix metalloproteinases, known to aggravate cartilage and @entity2 , and augmented expression of survivin by inhibiting @entity10 MAPK. Interestingly, osteotomized @entity1 treated with C. quadrangularis drastically enhanced alkaline phosphatase and cartilage tissue formation as compared to untreated, W. somnifera only, or the combination of both herbals. CONCLUSION: Our findings demonstrate for the first time the signaling mechanisms regulated by C. quadrangularis and W. somnifera in @entity6 and osteogenesis. We suggest that the chondroprotective effects and regenerative ability of these herbals are via the upregulation of survivin that exerts inhibitory effects on the @entity10 MAPK signaling pathway. These findings thus validate C. quadrangularis as a potential therapeutic for @entity7 .

title: Cissus quadrangularis inhibits @entity9 induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized XXXX via @entity10 MAPK signaling.

answer: @entity1


abstract: BACKGROUND: Opioids are used for the treatment of @entity1 . However, 30-50% of @entity0 have insufficient effect to the opioid initially selected by the physician, and there is an urgent need for biomarkers to select responders to the most appropriate drug. Since opioids mediate their effect in the central nervous system, this study aimed to investigate if electroencephalography (EEG) during rest or @entity1 before treatment could predict the analgesic response. METHODS: EEG from 62 channels was recorded in volunteers during rest and @entity1 (cold pressor test). @entity2 (30  mg) or placebo was then administered, and the @entity1 test repeated 60  min after. Washout period between drugs was 7  days. Based on @entity1 ratings, subjects were stratified into responders and non-responders. Spectral analysis was performed on the EEG. Conventional statistics on group basis were used and, furthermore, the most discriminative EEG features were subjected to support vector machine classification to predict the response for the individual subjects. RESULTS: Conventional statistics on the frequency bands revealed no differences between responders and non-responders. On the individual basis, no differences between groups were found using resting EEG. However, EEG during @entity1 was able to classify responders with an accuracy of 72% (p  =  0.01) and the result was reproducible using baseline data from both study days. CONCLUSIONS: Machine learning based on EEG before treatment enabled separation between responders and non-responders. This study represents the first step towards the prediction of @entity3 based on EEG features prior to drug administration, and advocates for the use of machine learning in future studies.

title: Machine learning on encephalographic activity may predict XXXX .

answer: @entity3


abstract: INTRODUCTION: With increasing survival rates after treatment for @entity1 in prepubertal @entity0 and @entity0 of reproductive age, an increasing focus on quality of life has emerged. Both irradiation and cytotoxic drugs can be detrimental to future fertility, consequently several treatment alternatives have been developed to spare or restore fertility in young females diagnosed with @entity1 . One of these options is cryopreservation of ovarian tissue before treatment and autotransplantation at a later time. MATERIAL AND METHODS: We present the Norwegian experience after 11 years of practice with ovarian tissue cryopreservation. A total of 164 @entity0 have had ovarian tissue cryopreserved during the period 2004-2014. Fifteen @entity0 died during the observation period. Six @entity0 requested autotransplantation, which was performed in two @entity0 . RESULTS: Both @entity0 conceived, one spontaneously and one after assisted reproduction due to a concomitant male factor. The pregnancies were uneventful and they each gave birth to a healthy @entity0 . CONCLUSIONS: Cryopreservation with later autotransplantation of ovarian tissue should be offered to a selected group of young @entity0 with @entity1 .

title: Autotransplantation of cryopreserved ovarian tissue after treatment for XXXX - the first Norwegian results.

answer: @entity1


abstract: UNASSIGNED: Results of @entity1 treatment have improved markedly over the past 30 years. In @entity2 , the 5-year event-free survival (EFS) rate was 81.5% in a retrospective study. In the ALB-NHL03 study, the five-year EFS according to clinical stage in @entity0 with @entity3 was 70.6% for stage III and 88.9% for stage IV. In @entity4 , the B-NHL03 study indicated that the 4-year EFS according to treatment group was 94% for Group 1, 98% for Group 2, 84% for Group 3, and 78% for Group 4 based on. Moreover, the two-year EFS rate was 81% in Japanese advanced stage @entity0 based on the international ALCL99 study. Thus, an EFS rate of over 80% was achieved in any subtype of @entity1 . However, @entity0 with refractory or recurrent @entity1 also exist and treatment methods for improvement of the survival rate of these @entity0 have to be developed. It's also a future problem to make the difference between the @entity0 and adolescent and young adult generation clear and develop treatment protocol. Although @entity1 treatment does not greatly change according to country, it does differ between other countries and Japan for some subtypes of @entity1 . In particular, the results of treatment of stage III T-LBL in Japan are worse than those of the US and European countries. It will be important to obtain evidence regarding these differences, and the reasons for these differences, in future studies. This article is protected by copyright. All rights reserved.

title: Treatment of XXXX in Japan -The current status and the future plan.

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: The ability to predict future clinical deterioration early in @entity0 who present to an emergency care center with a @entity1 is difficult. We studied the clinical usefulness of the initial serum levels of @entity3 in a @entity1 as an indicator for predicting aggravation in the early stages. METHODS: Of the @entity0 who presented with the clinical symptoms of a @entity1 , 99 were diagnosed with a @entity1 by imaging studies and subsequently enrolled in the study. Laboratory tests were obtained in the early stage of disease after presentation to an emergency care center. We assessed and compared the serum levels of many early inflammatory markers (white blood cell [WBC] counts, @entity2 and @entity3 ) between @entity0 whose symptoms were initially stable upon arrival to an emergency care center but then deteriorated to, those whose symptoms remained consistently stable. Thus, we examined if the above serum markers are useful in predicting the possibility of future symptom aggravation. RESULTS: Of a total of 99 @entity0 , 27 were assigned to the symptom aggravation group. The serum levels of WBC counts and @entity2 in the aggravation group were elevated. However, the median value (interquartile range) of @entity3 was relatively increased at 2.28 (0.41-7.84 ng/ml), demonstrating a significant difference. CONCLUSIONS: In conclusion, initial serum levels of @entity3 might be used as an indicator for aggravation in @entity0 with @entity1 at the emergency department, even though there is hemodynamic stability.

title: The clinical usefulness of initial serum XXXX as an aggravation predictor in a @entity1 at emergency department.

answer: @entity3


abstract: BACKGROUND AND OBJECTIVES: The ability to predict future clinical deterioration early in @entity0 who present to an emergency care center with a @entity1 is difficult. We studied the clinical usefulness of the initial serum levels of @entity3 in a @entity1 as an indicator for predicting aggravation in the early stages. METHODS: Of the @entity0 who presented with the clinical symptoms of a @entity1 , 99 were diagnosed with a @entity1 by imaging studies and subsequently enrolled in the study. Laboratory tests were obtained in the early stage of disease after presentation to an emergency care center. We assessed and compared the serum levels of many early inflammatory markers (white blood cell [WBC] counts, @entity2 and @entity3 ) between @entity0 whose symptoms were initially stable upon arrival to an emergency care center but then deteriorated to, those whose symptoms remained consistently stable. Thus, we examined if the above serum markers are useful in predicting the possibility of future symptom aggravation. RESULTS: Of a total of 99 @entity0 , 27 were assigned to the symptom aggravation group. The serum levels of WBC counts and @entity2 in the aggravation group were elevated. However, the median value (interquartile range) of @entity3 was relatively increased at 2.28 (0.41-7.84 ng/ml), demonstrating a significant difference. CONCLUSIONS: In conclusion, initial serum levels of @entity3 might be used as an indicator for aggravation in @entity0 with @entity1 at the emergency department, even though there is hemodynamic stability.

title: The clinical usefulness of initial serum @entity3 as an aggravation predictor in a XXXX at emergency department.

answer: @entity1


abstract: OBJECTIVES: The aim of this study is to compare the relative merits of optical coherence tomography (OCT), intravascular ultrasound (IVUS), and near infrared spectroscopy (NIRS) in @entity0 with @entity1 for the prediction of periprocedural @entity2 ( @entity2 ). BACKGROUND: Although several individual intravascular imaging modalities have been employed to predict periprocedural @entity2 , it is unclear which of the imaging tools would best allow prediction of this complication. METHODS: We retrospectively analyzed 110 @entity0 who underwent OCT, IVUS, and NIRS. Periprocedural @entity2 was defined as a post-procedural @entity3 ( @entity3 ) elevation above 3* the upper limit of normal; analysis was also performed for @entity3  >= 5* the upper limit of normal. RESULTS: @entity3  >= 3* was observed in 10 @entity0 (9%) and 8 @entity0 had @entity3  >= 5*. By OCT, minimum cap thickness was significantly lower (55 vs. 90  m, p  < 0.01), and the plaque burden by IVUS (84    9% vs. 77    8%, p  < 0.01) and maximum 4-mm lipid core burden index by NIRS (556 vs. 339, p  < 0.01) were greater in the @entity3  >= 3* group. Multivariate logistic regression analysis identified cap thickness as the only independent predictor for @entity3  >= 3* the upper limit of normal (odds ratio [OR]: 0.90, p  = 0.02) or @entity3  >= 5* (OR: 0.91, p  = 0.04). If OCT findings were excluded from the analysis, plaque burden (OR: 1.13, p  = 0.045) and maximum 4-mm lipid core burden index (OR: 1.003, p  = 0.037) emerged to be the independent predictors. CONCLUSIONS: OCT-based fibrous cap thickness is the most important predictor of periprocedural @entity2 . In the absence of information about cap thickness, NIRS lipid core or IVUS plaque burden best determined the likelihood of the periprocedural event.

title: Multimodality Intravascular Imaging to Predict Periprocedural XXXX During Percutaneous Coronary Intervention.

answer: @entity2


abstract: BACKGROUND: Blood pressure targets in individuals treated for @entity1 in primary care remain difficult to attain. AIMS: To assess the role of practice nurses in facilitating intensive and structured management to achieve ideal BP levels. METHODS: We analysed outcome data from the @entity2 Intensified Primary carE Reduction of Blood Pressure Study. @entity0 were randomly allocated (2:1) to the study intervention or usual care. Within both groups, a practice nurse mediated the management of blood pressure for 439 @entity0 with endpoint blood pressure data (n=1492). @entity0 management was categorised as: standard usual care (n=348, 23.3%); practice nurse-mediated usual care (n=156, 10.5%); standard intervention (n=705, 47.3%) and practice nurse-mediated intervention (n=283, 19.0%). Blood pressure goal attainment at 26-week follow-up was then compared. RESULTS: Mean age was 59.3  12.0 years and 62% were @entity0 . Baseline blood pressure was similar in practice nurse-mediated (usual care or intervention) and standard care management @entity0 (150    16/88    11 vs. 150    17/89    11 mmHg, respectively). Practice nurse-mediated @entity0 had a stricter blood pressure goal of    125/75 mmHg (33.7% vs. 27.3%, p=0.026). Practice nurse-mediated intervention @entity0 achieved the greatest blood pressure falls and the highest level of blood pressure goal attainment (39.2%) compared with standard intervention (35.0%), practice nurse-mediated usual care (32.1%) and standard usual care (25.3%; p<0.001). Practice nurse-mediated intervention @entity0 were almost two-fold more likely to achieve their blood pressure goal compared with standard usual care @entity0 (adjusted odds ratio 1.92, 95% confidence interval 1.32 to 2.78; p=0.001). CONCLUSION: There is greater potential to achieve blood pressure targets in primary care with practice nurse-mediated @entity1 management.

title: Impact of nurse-mediated management on achieving blood pressure goal levels in primary care: Insights from the XXXX Intensified Primary carE Reduction of Blood Pressure Study.

answer: @entity2


abstract: The cell cycle transition and differentiation-associated surface antigen expression was studied in a clone of @entity5 ( @entity5 ) with phenotypic properties similar to those of resting B lymphocytes. Differentiation was induced with @entity4 ( @entity3 ) and defined and quantitated by morphological and functional markers. Changes in the cell cycle position were determined by flow cytometry of @entity10 orange-stained cells. The uninduced @entity5 cells represented a homogeneous population with the same cell cycle position (GO) as resting normal peripheral blood lymphocytes. After five days of @entity4 stimulation, 56% of the @entity5 cells were found in @entity11 , 9% in G1B, and 3% in the S + G2/M phase, of which 2% was accounted to proliferating T cells. The cell cycle transition of the differentiating @entity5 cells was also examined using cell cycle-associated surface antigens as markers. HLA-DR and @entity9 antigens were present already on noninduced cells. The former had a high constant expression, while the amount of @entity9 increased upon induction. The @entity13 antigen was absent on noninduced cells but present on 86% of the induced cells. @entity12 ( @entity14 ) was expressed by the majority of the cells before @entity4 treatment and decreased to almost undetectable levels within 24 hours. Two antigens related to late stages of the cell cycle, the @entity6 ( @entity6 ; @entity8 ) and the @entity0 receptor, were present on about 20% of the induced cells. Experiments with enriched T cells showed that T but not B cells incorporated @entity2 . Taken together these results and previous work on the induction of the protooncogene @entity1 and @entity7 suggest that this @entity5 clone represents GO cells that undergo differentiation without concomitant proliferation when exposed to @entity4 .

title: Cell cycle progression of B-chronic lymphocytic leukemia cells induced to differentiate by XXXX .

answer: @entity4


abstract: UNASSIGNED: @entity7 (TL) is known to suppress the proliferation of a number of @entity4 cell lines in  vitro. Marked antitumor effects were also observed in a xenograft model of @entity4 . @entity3  -inducible factor  -1a ( @entity6 ) is highly expressed in @entity4 cells lines. The present study therefore tested the hypothesis that suppression of @entity6 is associated with the antitumor activity of TL. Quantitative polymerase chain reaction and western blot analysis were used to determine the level of gene expression. A xenograft @entity0 model of @entity4 was established in athymic @entity1 and the @entity0 size was measured to evaluate the outcome of TL treatment. Immunohistochemistry was used to detect the expression of @entity6 and @entity5 ( @entity5 ), and to assess microvessel density. Microarray was used to investigate gene expression in @entity4 cells following TL treatment. The expression of @entity6 was shown to be reduced in pancreatic cell lines following treatment with TL, and this effect occurred in a dose  -dependent manner. In a xenograft model of @entity4 , reduced levels of @entity6 were also observed in @entity1 that were treated with TL. Furthermore, the expression of @entity5 , which is a direct target of @entity6 , was also suppressed, and the microvessel density of @entity0 tissues was consequently reduced. A microarray analysis of gene expression was performed in order to investigate the potential mechanisms underlying the antitumor activity of TL. The results showed that 11 genes, including c  -Myc, @entity2 and @entity8 , were downregulated at an early stage following treatment with TL. A recent study indicated that overexpression of c  -Myc in colon @entity0 cells promotes increased expression of @entity6 and @entity5 . Therefore, TL may suppress @entity6 through a c  -Myc  -dependent mechanism, which is involved in antitumor effects in @entity1 models of @entity4 .

title: @entity7 suppresses proliferation, XXXX -inducible  factor-1a and c-Myc expression in @entity4 cells.

answer: @entity3


abstract: UNASSIGNED: @entity7 (TL) is known to suppress the proliferation of a number of @entity4 cell lines in  vitro. Marked antitumor effects were also observed in a xenograft model of @entity4 . @entity3  -inducible factor  -1a ( @entity6 ) is highly expressed in @entity4 cells lines. The present study therefore tested the hypothesis that suppression of @entity6 is associated with the antitumor activity of TL. Quantitative polymerase chain reaction and western blot analysis were used to determine the level of gene expression. A xenograft @entity0 model of @entity4 was established in athymic @entity1 and the @entity0 size was measured to evaluate the outcome of TL treatment. Immunohistochemistry was used to detect the expression of @entity6 and @entity5 ( @entity5 ), and to assess microvessel density. Microarray was used to investigate gene expression in @entity4 cells following TL treatment. The expression of @entity6 was shown to be reduced in pancreatic cell lines following treatment with TL, and this effect occurred in a dose  -dependent manner. In a xenograft model of @entity4 , reduced levels of @entity6 were also observed in @entity1 that were treated with TL. Furthermore, the expression of @entity5 , which is a direct target of @entity6 , was also suppressed, and the microvessel density of @entity0 tissues was consequently reduced. A microarray analysis of gene expression was performed in order to investigate the potential mechanisms underlying the antitumor activity of TL. The results showed that 11 genes, including c  -Myc, @entity2 and @entity8 , were downregulated at an early stage following treatment with TL. A recent study indicated that overexpression of c  -Myc in colon @entity0 cells promotes increased expression of @entity6 and @entity5 . Therefore, TL may suppress @entity6 through a c  -Myc  -dependent mechanism, which is involved in antitumor effects in @entity1 models of @entity4 .

title: XXXX suppresses proliferation, @entity3 -inducible  factor-1a and c-Myc expression in @entity4 cells.

answer: @entity7


abstract: UNASSIGNED: @entity7 (TL) is known to suppress the proliferation of a number of @entity4 cell lines in  vitro. Marked antitumor effects were also observed in a xenograft model of @entity4 . @entity3  -inducible factor  -1a ( @entity6 ) is highly expressed in @entity4 cells lines. The present study therefore tested the hypothesis that suppression of @entity6 is associated with the antitumor activity of TL. Quantitative polymerase chain reaction and western blot analysis were used to determine the level of gene expression. A xenograft @entity0 model of @entity4 was established in athymic @entity1 and the @entity0 size was measured to evaluate the outcome of TL treatment. Immunohistochemistry was used to detect the expression of @entity6 and @entity5 ( @entity5 ), and to assess microvessel density. Microarray was used to investigate gene expression in @entity4 cells following TL treatment. The expression of @entity6 was shown to be reduced in pancreatic cell lines following treatment with TL, and this effect occurred in a dose  -dependent manner. In a xenograft model of @entity4 , reduced levels of @entity6 were also observed in @entity1 that were treated with TL. Furthermore, the expression of @entity5 , which is a direct target of @entity6 , was also suppressed, and the microvessel density of @entity0 tissues was consequently reduced. A microarray analysis of gene expression was performed in order to investigate the potential mechanisms underlying the antitumor activity of TL. The results showed that 11 genes, including c  -Myc, @entity2 and @entity8 , were downregulated at an early stage following treatment with TL. A recent study indicated that overexpression of c  -Myc in colon @entity0 cells promotes increased expression of @entity6 and @entity5 . Therefore, TL may suppress @entity6 through a c  -Myc  -dependent mechanism, which is involved in antitumor effects in @entity1 models of @entity4 .

title: @entity7 suppresses proliferation, @entity3 -inducible  factor-1a and c-Myc expression in XXXX cells.

answer: @entity4


abstract: Forty @entity0 with @entity9 were evaluated prospectively with CT and intermediate-field-strength MR imaging to compare the diagnostic efficacies of the two techniques. @entity4 were detected in 38 @entity0 . The severity of injury, as determined by the Glascow @entity7 Scale, ranged from 3 to 14. The sensitivities of CT and MR were calculated for all subgroups of lesions: (1) hemorrhagic and @entity2 ( @entity1 , @entity4 , subcortical gray-matter injury, primary @entity3 ); (2) extraaxial @entity8 (subdural, epidural); and (3) diffuse @entity6 (subarachnoid, intraventricular). CT and MR (T1- and T2-weighted) studies were both highly and comparably sensitive in the detection of @entity6 . MR scans, however, were much more sensitive in detecting @entity2 . cortical contusions and @entity1 constituted 91.9% of all intraaxial lesions. The sensitivities of the imaging techniques for this combined group of lesions were (1) @entity2 (CT = 17.7%, T1-weighted MR = 67.6%, T2-weighted MR = 93.3%); (2) @entity6 (CT = 89.8%, T1-weighted MR = 87.1%, T2-weighted MR = 92.5%). MR was also significantly better in detecting @entity2 (CT = 9.1%, T1-weighted MR = 81.8%, T2-weighted MR = 72.7%). The sensitivities of the diagnostic studies in the detection of extraaxial @entity8 were CT = 73.2%, T1-weighted MR = 97.6%, T2-weighted MR = 90.5%). @entity6 was consistently seen with all three imaging studies, but @entity5 was detected much more frequently with CT. In summary, MR has clear advantages over CT in evaluating @entity9 . Although its sensitivity in detecting @entity6 is similar to that of CT, it is much better than CT in detecting @entity2 , which are more prevalent. MR is more useful than CT in classifying primary and secondary forms of injury and directing treatment. CT's one advantage over MR is its ability to more rapidly assess unstable @entity0 who may need surgery.

title: Prospective comparative study of intermediate-field MR and CT in the evaluation of XXXX .

answer: @entity9


abstract: INTRODUCTION: The objective of this study was to evaluate the feasibility of thoracoscopic thymectomy (TT) for treatment of @entity1 and to compare the outcomes with those after open thymectomy (OT). METHODS: A retrospective review of 98 @entity0 who underwent TT or OT of Masaoka @entity2 without thymic cancer between 1996 and 2013 was performed. RESULTS: Thoracoscopic thymectomy was performed in 67 @entity0 , and OT was performed in 31 @entity0 . The intraoperative @entity3 amounts differed significantly between the TT group and OT group (100 vs 185   mL, P   =   0.0070). The postoperative hospital stay was significantly shorter in the TT group than in the OT group (4 vs 12 days, P   <   0.0001). No @entity0 in the TT group underwent conversion to open surgery, and no surgical complications, such as @entity4 , were observed. Two @entity0 experienced recurrence in the TT group during the median postoperative follow-up period of 65 months. No significant differences were found in the 5-year disease-free survival rates between the two groups. There were no significant differences in disease-free survival as classified by Masaoka stage, World Health Organization type, and the extent of resection of the thymus. CONCLUSION: Our outcome showed that TT largely reduced the degree of invasiveness. The outcome was not inferior to that of OT. The results primarily demonstrated the feasibility of TT for treatment of @entity1 .

title: Feasibility of thoracoscopic thymectomy for treatment of XXXX .

answer: @entity1


abstract: We examined a family in which two brothers with identical HLA typing have @entity2 with snowbanking. Immunopathological studies of one of their eyes showed that in the area of snowbanking over the pars plana there was mild to moderate @entity1 , consisting of mostly Pan T (Leu 4+) lymphocytes. The ratio of T helper/inducer to T suppressor/cytotoxic cells was approximately 10:1. Few macrophages ( @entity0 +) were identified. Very few B cells and no NK cells were observed. Some retinal vessels had a perivascular infiltration consisting of mostly T lymphocytes. Most of the inflammatory cells bore class II antigens (HLA-DR+), while T cells bore few IL-2 receptors (anti-TAC+). The snowbank consisted mainly of glial elements (GFAP+) and basement membrane components (type IV collagen and laminin) with the predominant cell the M  ller cell (M  +). A site of @entity1 at the iris-ciliary body junction also stained for B cells (Leu 14+). These findings suggest that the snowbank could be formed by the glial elements of the peripheral retina. The @entity1 in @entity2 appears to consist of helper T cells, both in the pars plana, and the retinal vasculature.

title: Clinical and immunopathological studies of XXXX in a family.

answer: @entity2


abstract: PURPOSE: To explore mild @entity3 and/or spatial working @entity6 in @entity0 with primary onset @entity1 (T2DM] using ethology (behavior tests) and blood @entity2 level-dependent functional magnetic resonance imaging (BOLD-fMRI). MATERIALS AND METHODS: Eighteen primary onset T2DM @entity0 and 18 matched subjects with normal blood @entity5 levels were all tested using the Montreal cognitive assessment scale test, the Wechsler Memory Scale Chinese-revised test, and scanned using BOLD-fMRI (1.5T, EPI sequence) while performing the n-back task to find the activation intensity of some cognition-related areas. RESULTS: The ethology results showed that T2DM @entity0 had a mild @entity3 and @entity6 (P   <   0.05). The fMRI scan identified a neural network consisting of bilateral dorsolateral prefrontal cortex (DLPFC), bilateral premotor area (PreMA), bilateral parietal lobe (PA), and anterior cingulate cortex (ACC) / @entity8 ( @entity8 ) that was activated during the n-back task, with right hemisphere dominance. However, only the right PA and ACC/ @entity8 showed a load effect via quantitative analysis in the T2DM group; the activation intensity of most working memory-related brain areas for the T2DM group were lower than for the control group under three memory loads. Furthermore, we found that the activation intensity of some cognition-related areas, including the @entity7 , left caudate nucleus, and bilateral hippocampus/parahippocampal gyrus were lower than the control group under the memory loads. CONCLUSION: @entity1 -related @entity4 of primary onset middle-age T2DM @entity0 with right DLPFC-posterior parietal lobe and @entity9 causes @entity3 and mild @entity3 .J. Magn. Reson. Imaging 2015.

title: Spatial working XXXX in primary onset @entity1 : An ethology and BOLD-fMRI study.

answer: @entity6


abstract: PURPOSE: To explore mild @entity3 and/or spatial working @entity6 in @entity0 with primary onset @entity1 (T2DM] using ethology (behavior tests) and blood @entity2 level-dependent functional magnetic resonance imaging (BOLD-fMRI). MATERIALS AND METHODS: Eighteen primary onset T2DM @entity0 and 18 matched subjects with normal blood @entity5 levels were all tested using the Montreal cognitive assessment scale test, the Wechsler Memory Scale Chinese-revised test, and scanned using BOLD-fMRI (1.5T, EPI sequence) while performing the n-back task to find the activation intensity of some cognition-related areas. RESULTS: The ethology results showed that T2DM @entity0 had a mild @entity3 and @entity6 (P   <   0.05). The fMRI scan identified a neural network consisting of bilateral dorsolateral prefrontal cortex (DLPFC), bilateral premotor area (PreMA), bilateral parietal lobe (PA), and anterior cingulate cortex (ACC) / @entity8 ( @entity8 ) that was activated during the n-back task, with right hemisphere dominance. However, only the right PA and ACC/ @entity8 showed a load effect via quantitative analysis in the T2DM group; the activation intensity of most working memory-related brain areas for the T2DM group were lower than for the control group under three memory loads. Furthermore, we found that the activation intensity of some cognition-related areas, including the @entity7 , left caudate nucleus, and bilateral hippocampus/parahippocampal gyrus were lower than the control group under the memory loads. CONCLUSION: @entity1 -related @entity4 of primary onset middle-age T2DM @entity0 with right DLPFC-posterior parietal lobe and @entity9 causes @entity3 and mild @entity3 .J. Magn. Reson. Imaging 2015.

title: Spatial working @entity6 in primary onset XXXX : An ethology and BOLD-fMRI study.

answer: @entity1


abstract: OBJECTIVE: The aim of the present study was to investigate the relationship between @entity6 and @entity7 gene polymorphisms and plasma lipid concentrations in Turkish @entity0 with @entity1 . METHODS: Included in this study were 80 @entity0 with @entity2 2 @entity1 and 73 healthy controls. Two selected single @entity5 polymorphisms in ABC transporter genes, @entity6 ( @entity8 ) and @entity7 ( @entity9 ), were genotyped by using the polymerase chain reaction-restriction fragment length polymorphism technique. RESULTS: The rate of having the @entity7 AA genotype (p=0.001) was significantly higher in the @entity0 than in the control subjects. Correspondingly, the rates of having the AG genotype (p=0.001) and the G allele (p=0.001) were significantly lower in the @entity0 than in controls. Upon comparing the groups regarding @entity6 , the frequencies of occurrence of the GG genotype (p=0.031) and G allele (p=0.003) were considerably higher in @entity0 than in control subjects. In the @entity0 , the rates of having the CC genotype (p=0.003) and the C allele (p=0.031) were also significantly lower than those in control subjects. There was no significant difference between G5 and G8 polymorphism and lipid levels in the study groups. The @entity7 AA genotype carriers had higher @entity4 (p=0.045) and very low-density- @entity3 (p=0.045) levels than the @entity7 GG genotype carriers in all study populations. CONCLUSIONS: These results indicate that the AA genotype for @entity7 and the GG genotype and G allele for @entity6 are risk factors for @entity1 . This study reveals the first data concerning the @entity6 and @entity7 gene polymorphisms in Turkish @entity0 with @entity1 .

title: @entity6 and @entity7 Gene Polymorphisms in Type 2 XXXX in the Turkish Population.

answer: @entity1


abstract: OBJECTIVE: The aim of the present study was to investigate the relationship between @entity6 and @entity7 gene polymorphisms and plasma lipid concentrations in Turkish @entity0 with @entity1 . METHODS: Included in this study were 80 @entity0 with @entity2 2 @entity1 and 73 healthy controls. Two selected single @entity5 polymorphisms in ABC transporter genes, @entity6 ( @entity8 ) and @entity7 ( @entity9 ), were genotyped by using the polymerase chain reaction-restriction fragment length polymorphism technique. RESULTS: The rate of having the @entity7 AA genotype (p=0.001) was significantly higher in the @entity0 than in the control subjects. Correspondingly, the rates of having the AG genotype (p=0.001) and the G allele (p=0.001) were significantly lower in the @entity0 than in controls. Upon comparing the groups regarding @entity6 , the frequencies of occurrence of the GG genotype (p=0.031) and G allele (p=0.003) were considerably higher in @entity0 than in control subjects. In the @entity0 , the rates of having the CC genotype (p=0.003) and the C allele (p=0.031) were also significantly lower than those in control subjects. There was no significant difference between G5 and G8 polymorphism and lipid levels in the study groups. The @entity7 AA genotype carriers had higher @entity4 (p=0.045) and very low-density- @entity3 (p=0.045) levels than the @entity7 GG genotype carriers in all study populations. CONCLUSIONS: These results indicate that the AA genotype for @entity7 and the GG genotype and G allele for @entity6 are risk factors for @entity1 . This study reveals the first data concerning the @entity6 and @entity7 gene polymorphisms in Turkish @entity0 with @entity1 .

title: XXXX and @entity7 Gene Polymorphisms in Type 2 @entity1 in the Turkish Population.

answer: @entity6


abstract: OBJECTIVE: The aim of the present study was to investigate the relationship between @entity6 and @entity7 gene polymorphisms and plasma lipid concentrations in Turkish @entity0 with @entity1 . METHODS: Included in this study were 80 @entity0 with @entity2 2 @entity1 and 73 healthy controls. Two selected single @entity5 polymorphisms in ABC transporter genes, @entity6 ( @entity8 ) and @entity7 ( @entity9 ), were genotyped by using the polymerase chain reaction-restriction fragment length polymorphism technique. RESULTS: The rate of having the @entity7 AA genotype (p=0.001) was significantly higher in the @entity0 than in the control subjects. Correspondingly, the rates of having the AG genotype (p=0.001) and the G allele (p=0.001) were significantly lower in the @entity0 than in controls. Upon comparing the groups regarding @entity6 , the frequencies of occurrence of the GG genotype (p=0.031) and G allele (p=0.003) were considerably higher in @entity0 than in control subjects. In the @entity0 , the rates of having the CC genotype (p=0.003) and the C allele (p=0.031) were also significantly lower than those in control subjects. There was no significant difference between G5 and G8 polymorphism and lipid levels in the study groups. The @entity7 AA genotype carriers had higher @entity4 (p=0.045) and very low-density- @entity3 (p=0.045) levels than the @entity7 GG genotype carriers in all study populations. CONCLUSIONS: These results indicate that the AA genotype for @entity7 and the GG genotype and G allele for @entity6 are risk factors for @entity1 . This study reveals the first data concerning the @entity6 and @entity7 gene polymorphisms in Turkish @entity0 with @entity1 .

title: @entity6 and XXXX Gene Polymorphisms in Type 2 @entity1 in the Turkish Population.

answer: @entity7


abstract: The aim of the present study is to compare the effect of electrical muscle stimulation combined with @entity2 with a program only with @entity2 during immobilization in casts after anterior cruciate ligament surgery. Twenty-three @entity0 , 7 @entity0 and 16 @entity0 with a mean age of 28 yr, were randomized into two groups: an experimental group (13 @entity0 ) and a control group (10 @entity0 ). Post-operatively, the @entity0 were immobilized for 3 wk in a full leg cast with the knee flexed at an angle of 20 degrees to 30 degrees and then in a knee cast for another 3 wk. All @entity0 had a standard program with @entity1 . In addition, the experimental group received electrical stimulation of the @entity1 4 X 10 min, 3 times.wk-1, at a frequency of 30 Hz. During each stimulation, the @entity0 were requested to contract the @entity1 voluntarily as well. When pre-operative measurements were compared with those at the end of the immobilization period (6 wk after the operation), a significantly larger reduction in the knee extension isometric muscle strength was found for the control group than for the experimental group. In comparisons of the data of the male subjects only, this difference was still seen to be significant. The cross-sectional area of the @entity1 measured with computed tomography was significantly less reduced during the immobilization period in the experimental group than in the control group.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effects of electrical muscle stimulation combined with XXXX after knee ligament surgery.

answer: @entity2


abstract: Male @entity0 treated with either @entity1 or @entity2 , two peroxisome proliferating compounds with potent hypolipidemic properties, show identical structural changes in their lungs. In both cases, two types of lung cells were affected by these agents: (i) the alveolar epithelial cells type II and (ii) the intraalveolar macrophages. These lung cells are known to be involved in the metabolism of the pulmonary surfactant which serves to reduce the surface tension within alveoli. The size of the alveolar cells type II was conspicuously increased in the treated lungs. Compared to controls, intraalveolar macrophages apparently were slightly more numerous. Their enlarged cytoplasm was strongly vacuolated. The osmiophilic lamellar bodies within alveolar cells type II represent the intracellular presecretory pulmonary surfactant. Their number per individual alveolar cell type II was estimated by means of light microscopic morphometry on Epon-embedded semithin sections. Compared to control lungs, the number was increased by about 30% in @entity0 treated with @entity1 (11.4 +/- 0.5 lamellar inclusions in the control cells; P less than 0.001). The increase in the number of lamellar bodies per type II cell was close to 60% in animals fed the nafenopin diet. In contrast the frequency of alveolar cells type II, estimated per area of lung tissue, remained unchanged. These results demonstrate that @entity1 and nafenopin, two drugs with hypolipidemic properties, cause identical structural changes in the rodent lung. It is concluded from these data that (i) the morphological changes observed in the surfactant metabolizing cells represent a specific action of hypolipidemic agents at the lungs and (ii) hypolipidemic peroxisome proliferators influence the metabolism of the pulmonary surfactant.

title: Two hypolipidemic peroxisome proliferators increase the number of lamellar bodies in alveolar cells type II of the XXXX lung.

answer: @entity0


abstract: AIMS: @entity1 and @entity3 -related pharmaceuticals have the potential to modulate micturition and continence. The aim of this study was to determine if treatment with @entity1 and/or @entity3 improves stress @entity2 (SUI) in female @entity0 . METHODS: Twenty-six age-matched female @entity0 underwent @entity4 (PNC   +   VD), to produce SUI. One week after injury, @entity0 were treated subcutaneously with saline, @entity1 (1.1    g), @entity3 (2 g), or the combination of both twice daily for another week. A sham injured group received sham PNC   +   VD and were treated with saline (n   =   7). Leak point pressure (LPP) testing with simultaneous external urethral sphincter (EUS) electromyography (EMG) was conducted 2 weeks after injury. The urethra was harvested for qualitative and quantitative histology. Data were analyzed with a one-way ANOVA and Student-Newman-Keuls posthoc test with P   <   0.05 indicating statistically significant differences between groups. RESULTS: Combination treatment significantly increased LPP after PNC   +   VD compared to injured sham treatment and treatment with either @entity1 or @entity3 alone. Compared to injured sham treated @entity0 , all three treatments significantly increased EUS EMG amplitude at both baseline and peak pressure and EUS EMG firing rate at peak pressure during LPP testing. There were more consistent urethral striated muscle fibers and thicker smooth and striated muscle with combination and @entity1 treatment. There was a statistically significant shift to a greater proportion of thicker collagen fibers in the urethra in @entity3 and combination treated @entity0 compared with injured sham treated @entity0 . CONCLUSIONS: Combination treatment was the most effective and may provide an effective therapy for SUI. Neurourol. Urodynam.    2015 Wiley Periodicals, Inc.

title: Combination @entity1 and @entity3 treatment after simulated childbirth injury improves stress XXXX .

answer: @entity2


abstract: AIMS: @entity1 and @entity3 -related pharmaceuticals have the potential to modulate micturition and continence. The aim of this study was to determine if treatment with @entity1 and/or @entity3 improves stress @entity2 (SUI) in female @entity0 . METHODS: Twenty-six age-matched female @entity0 underwent @entity4 (PNC   +   VD), to produce SUI. One week after injury, @entity0 were treated subcutaneously with saline, @entity1 (1.1    g), @entity3 (2 g), or the combination of both twice daily for another week. A sham injured group received sham PNC   +   VD and were treated with saline (n   =   7). Leak point pressure (LPP) testing with simultaneous external urethral sphincter (EUS) electromyography (EMG) was conducted 2 weeks after injury. The urethra was harvested for qualitative and quantitative histology. Data were analyzed with a one-way ANOVA and Student-Newman-Keuls posthoc test with P   <   0.05 indicating statistically significant differences between groups. RESULTS: Combination treatment significantly increased LPP after PNC   +   VD compared to injured sham treatment and treatment with either @entity1 or @entity3 alone. Compared to injured sham treated @entity0 , all three treatments significantly increased EUS EMG amplitude at both baseline and peak pressure and EUS EMG firing rate at peak pressure during LPP testing. There were more consistent urethral striated muscle fibers and thicker smooth and striated muscle with combination and @entity1 treatment. There was a statistically significant shift to a greater proportion of thicker collagen fibers in the urethra in @entity3 and combination treated @entity0 compared with injured sham treated @entity0 . CONCLUSIONS: Combination treatment was the most effective and may provide an effective therapy for SUI. Neurourol. Urodynam.    2015 Wiley Periodicals, Inc.

title: Combination XXXX and @entity3 treatment after simulated childbirth injury improves stress @entity2 .

answer: @entity1


abstract: AIMS: @entity1 and @entity3 -related pharmaceuticals have the potential to modulate micturition and continence. The aim of this study was to determine if treatment with @entity1 and/or @entity3 improves stress @entity2 (SUI) in female @entity0 . METHODS: Twenty-six age-matched female @entity0 underwent @entity4 (PNC   +   VD), to produce SUI. One week after injury, @entity0 were treated subcutaneously with saline, @entity1 (1.1    g), @entity3 (2 g), or the combination of both twice daily for another week. A sham injured group received sham PNC   +   VD and were treated with saline (n   =   7). Leak point pressure (LPP) testing with simultaneous external urethral sphincter (EUS) electromyography (EMG) was conducted 2 weeks after injury. The urethra was harvested for qualitative and quantitative histology. Data were analyzed with a one-way ANOVA and Student-Newman-Keuls posthoc test with P   <   0.05 indicating statistically significant differences between groups. RESULTS: Combination treatment significantly increased LPP after PNC   +   VD compared to injured sham treatment and treatment with either @entity1 or @entity3 alone. Compared to injured sham treated @entity0 , all three treatments significantly increased EUS EMG amplitude at both baseline and peak pressure and EUS EMG firing rate at peak pressure during LPP testing. There were more consistent urethral striated muscle fibers and thicker smooth and striated muscle with combination and @entity1 treatment. There was a statistically significant shift to a greater proportion of thicker collagen fibers in the urethra in @entity3 and combination treated @entity0 compared with injured sham treated @entity0 . CONCLUSIONS: Combination treatment was the most effective and may provide an effective therapy for SUI. Neurourol. Urodynam.    2015 Wiley Periodicals, Inc.

title: Combination @entity1 and XXXX treatment after simulated childbirth injury improves stress @entity2 .

answer: @entity3


abstract: BACKGROUND: @entity1 ( @entity1 ) and @entity2 frequently occur together. The relationship between increased appetite and @entity2 is well known; however, despite existing knowledge about the relationship between @entity1 and @entity2 , it is not fully understood. OBJECTIVES: This study aimed to evaluate the relationship between @entity1 and the appetite-suppressing hormone @entity3 independent of body mass index (BMI). METHODS: A total of 134 cases were included in the study; 102 with @entity1 ( @entity1 group) and 32 healthy controls (control group). All cases underwent polysomnography, and @entity3 levels were determined. RESULTS: @entity3 levels were significantly lower in the @entity1 group compared to the control group (3,776.5    204.8 and 4,056.2    101.5 pg/ml, respectively; p < 0.001). In addition, there was a statistically significant negative correlation between @entity3 and the @entity1 index (r = -0.543; p < 0.001). The statistically significant relationship persisted after adjusting for confounding intergroup factors such as age, gender and BMI (p < 0.001). In the @entity1 group, there was a statistically significant correlation between @entity3 and neck circumference (r = -0.304; p = 0.02) but not between @entity3 and BMI and waist circumference. There was no statistically significant difference in @entity3 levels between the sexes. CONCLUSION: @entity1 @entity0 have lower @entity3 levels compared to controls, and a greater @entity3 deficit corresponds to an increased severity of @entity1 and an increased neck circumference. Replacement therapy may be a potential treatment for obese @entity1 @entity0 who have lower @entity3 levels, which may have additional benefits through appetite suppression and weight loss.    2015 S. Karger AG, Basel.

title: Is There a Relationship between Obstructive Sleep Apnea Syndrome Severity and XXXX ?

answer: @entity3


abstract: The aim of the present study was to examine effect of prolonged fasting on muscle glycogen and @entity1 concentration as well as on non-protein @entity5 excretion with urine in late pregnant @entity0 . They were divided into four groups: I--fed, pregnant for 21 days, II--fasted for one day (from 20 to 21 day of pregnancy), III--fasted for two days (from 19 to 21 day) and IV--fasted for three days (from 18 to 21 day). The concentration of glycogen and @entity6 was determined in the following tissues: the white and red layers of the vastus lateralis, the soleus, the diaphragm, the heart and the liver. The urine was collected in each group 24 h (from 20 to 21 day). It has been found that concentration of glycogen in the leg muscles is reduced by about 50% and in the diaphragm by 75% already after 24 h fasting and then remains stable. The concentration of glycogen in the heart increases after one day of fasting and then returns to the control value. The effect of fasting on the concentration of @entity6 in the tissues depends on a tissue studied. It decreases gradually in the white vastus, and in the soleus only on the third day. It is elevated during the first two days of fasting in the red vastus, diaphragm and liver and returns to the control level on the third day. The fasting doubled the concentration of @entity6 in the heart. The urinary @entity4 , @entity3 , and @entity2 excretion decreases and @entity7 excretion increases during fasting. The results obtained indicate that the late gestation does not alter response of muscle glycogen metabolism to fasting as compared to the male @entity0 . It does effect metabolism of @entity6 .

title: Metabolic response to starvation in late pregnant XXXX . I. Maternal response.

answer: @entity0


abstract: BACKGROUND: @entity3 ( @entity3 ) is the most common @entity1 observed in @entity0 . OBJECTIVES: The aims of this study were: (1) to analyze the evolution of a corrective bandage for semirigid @entity3 in newborns and (2) to recommend the age interval at which to start treatment of @entity3 with the corrective bandage alone, without the need of splints. DESIGN: An observational clinical study was conducted. METHODS: The study was conducted at Virgen Macarena University Hospital in Seville, Spain. @entity0 born with semirigid @entity3 at the hospital during the years 2010-2011 were included. Corrective bandaging was applied to all @entity0 until clinical correction of the deformity. Sex, laterality of the deformity, weight and length of the newborn, age at the start of treatment, antecedents related to the pregnancy and birth, type of treatment (bandaging, splints), and correction or no correction with bandaging alone were recorded. Age differences at the start of the bandaging treatment between @entity0 whose deformity was corrected with and without the need of splints were examined. The receiver operating characteristic curve method was applied to analyze the predictive ability of the age at the start of bandaging treatment relative to whether the deformity was corrected or not corrected with bandaging alone. RESULTS: The bandage achieved complete correction in 68.1% of the @entity0 and corrected the deformity more frequently in @entity0 compared with @entity0 . Of the 56 @entity0 who began the treatment within the first month of life, 92.8% achieved correction of the @entity2 with the corrective bandaging alone. LIMITATIONS: @entity0 ' follow-up time was only 2 years, so it was only feasible to analyze the corrective bandaging method over the short term and medium term. CONCLUSIONS: Corrective bandages showed high effectiveness, particularly in @entity0 , and overall when started within the first month of life.

title: Corrective Bandage for Conservative Treatment of XXXX : Retrospective Study.

answer: @entity3


abstract: UNASSIGNED: The @entity1 is the initial refractive interface of the eye. Its transparency is critical for clear vision and is maintained by stem cells which also act to repair injury inflicted by external insults such as @entity5 . Damage to the epithelium compromises its clarity and can reduce or eliminate the stem cell population, diminishing the ability for self-repair. This condition has been termed "limbal stem cell deficiency"; severe cases can lead to @entity2 . Sphere-forming cells isolated from peripheral @entity1 are a potential source of stem and progenitor cells for corneal repair. When provided with appropriate substrate, these spheres have the ability to adhere and for cells to migrate outwards akin to that of their natural environment. @entity4 and remote @entity0 experiments were conducted on the sphere cells to gauge their wound healing capacity. Measures of proliferation, differentiation and migration were assessed by immunohistochemical detection of EdU incorporation, a-smooth muscle actin expression and confocal image analysis respectively. Both modes of injury were observed to draw responses from the spheres indicating wound healing processes. Direct wounding induced a rapid, but transient increase in expression of @entity3 , a marker of corneal myofibroblasts, followed by a proliferative and increasing migratory response. The spheres were observed to respond to remote injury as entire units, with no directional response seen for targeted repair over the @entity0 area. These results give strength to the future use of these peripheral corneal spheres as transplantable units for the regeneration of corneal tissue.

title: Sphere-forming cells from peripheral XXXX demonstrate a wound-healing response to injury.

answer: @entity1


abstract: BACKGROUND: The mid-term results of valve-sparing aortic root reimplantation (VSRR) for various indications were investigated. METHODS: From 2000 to 2013, 183 consecutive @entity0 undergoing VSRR were enrolled. Expanded indications, defined as a @entity0 on the marginal operative indication, included age 65 years or older (n  = 33), age 15 years or younger (n  = 4), acute @entity3 (AAAD) (n  = 21), @entity4 (n  = 8), reoperative root replacement (n  = 11), cusp prolapse (n  = 67), large aortoventricular junction of greater than 28 mm (AVJ) (n  = 42), preoperative severe @entity1 ( @entity1 ) (n  = 89), left ventricular ejection fraction 0.40 or less (n  = 12), @entity2 (n  = 66), New York Heart Association class III or greater (n  = 5), need for total arch replacement (n  = 29), and concomitant mitral valve repair (n  = 12). RESULTS: The overall survival at 5 years was 96.6%. Freedom from greater than mild @entity1 and reoperation at 5 years was 85.8% and 92.9%, respectively. Cox proportional hazard model revealed that AAAD, cusp prolapse, AVJ 28 mm or greater, and operation before 2009 were at risk for late @entity1 recurrence (p  = 0.015, p  = 0.0041, p  = 0.032, and p  = 0.014, respectively). After 2009, freedom from late @entity1 in the cusp prolapse group improved (p  = 0.055, versus control). Both freedom from recurrent @entity1 and reoperation were worse as the number of expanded indications increased (log-rank trend p = 0.00017 and p  = 0.00067, respectively). CONCLUSIONS: Surgical outcomes of VSRR in these @entity0 cohorts were satisfactory with some room for improvement in @entity0 with cusp prolapse. Although the indications for VSRR are being expanded, a larger number of expanded indications were associated with poor outcomes in terms of longevity of valve function.

title: Mid-Term Results of Valve-Sparing Aortic Root Replacement in XXXX With Expanded Indications.

answer: @entity0


abstract: PURPOSE: To explore whether @entity4 surgery contributes to the progression of wet age-related @entity6 (wet @entity9 ). DESIGN: Retrospective cohort study. METHODS: Retrospective review was performed of consecutive @entity0 with wet @entity9 who underwent @entity4 surgery at the midpoint of a 1-year study window. A control arm included wet @entity9 eyes treated with @entity2 ( @entity2 ) injections that did not undergo @entity4 surgery for a 1-year period. Best-corrected visual acuity (BCVA), number of anti- @entity2 injections, and optical coherence tomography (OCT) features were compared between the 2 arms. RESULTS: Forty eyes in the surgical group and 42 in the nonsurgical group were included. BCVA was equivalent in the first half of the study, and became significantly better in the surgical group vs the nonsurgical group (0.23    0.65 vs 0.11    0.59 logMAR improvement, P  = .049). There was no change in the number of injections given 6  months before vs after the midpoint in the surgical group (P  = .921). The mean OCT central @entity8 compared to nonsurgical eyes (265.4    98.4   m vs 216.4    58.3   m, P  = .011). @entity5 were more likely to develop new or worse cystoid changes after the study midpoint (13 surgical eyes [54.2%] vs 9 nonsurgical eyes [28.1%], P  = .048). CONCLUSIONS: Cataract surgery leads to vision improvement and does not appear to contribute to worsening of wet @entity9 . However, anatomic changes based on OCT analysis suggest a subclinical susceptibility to @entity3 macular @entity1 or exacerbation of @entity7 .

title: The effects of @entity4 surgery on @entity0 with wet XXXX .

answer: @entity6


abstract: PURPOSE: To explore whether @entity4 surgery contributes to the progression of wet age-related @entity6 (wet @entity9 ). DESIGN: Retrospective cohort study. METHODS: Retrospective review was performed of consecutive @entity0 with wet @entity9 who underwent @entity4 surgery at the midpoint of a 1-year study window. A control arm included wet @entity9 eyes treated with @entity2 ( @entity2 ) injections that did not undergo @entity4 surgery for a 1-year period. Best-corrected visual acuity (BCVA), number of anti- @entity2 injections, and optical coherence tomography (OCT) features were compared between the 2 arms. RESULTS: Forty eyes in the surgical group and 42 in the nonsurgical group were included. BCVA was equivalent in the first half of the study, and became significantly better in the surgical group vs the nonsurgical group (0.23    0.65 vs 0.11    0.59 logMAR improvement, P  = .049). There was no change in the number of injections given 6  months before vs after the midpoint in the surgical group (P  = .921). The mean OCT central @entity8 compared to nonsurgical eyes (265.4    98.4   m vs 216.4    58.3   m, P  = .011). @entity5 were more likely to develop new or worse cystoid changes after the study midpoint (13 surgical eyes [54.2%] vs 9 nonsurgical eyes [28.1%], P  = .048). CONCLUSIONS: Cataract surgery leads to vision improvement and does not appear to contribute to worsening of wet @entity9 . However, anatomic changes based on OCT analysis suggest a subclinical susceptibility to @entity3 macular @entity1 or exacerbation of @entity7 .

title: The effects of XXXX surgery on @entity0 with wet @entity6 .

answer: @entity4


abstract: PURPOSE: To explore whether @entity4 surgery contributes to the progression of wet age-related @entity6 (wet @entity9 ). DESIGN: Retrospective cohort study. METHODS: Retrospective review was performed of consecutive @entity0 with wet @entity9 who underwent @entity4 surgery at the midpoint of a 1-year study window. A control arm included wet @entity9 eyes treated with @entity2 ( @entity2 ) injections that did not undergo @entity4 surgery for a 1-year period. Best-corrected visual acuity (BCVA), number of anti- @entity2 injections, and optical coherence tomography (OCT) features were compared between the 2 arms. RESULTS: Forty eyes in the surgical group and 42 in the nonsurgical group were included. BCVA was equivalent in the first half of the study, and became significantly better in the surgical group vs the nonsurgical group (0.23    0.65 vs 0.11    0.59 logMAR improvement, P  = .049). There was no change in the number of injections given 6  months before vs after the midpoint in the surgical group (P  = .921). The mean OCT central @entity8 compared to nonsurgical eyes (265.4    98.4   m vs 216.4    58.3   m, P  = .011). @entity5 were more likely to develop new or worse cystoid changes after the study midpoint (13 surgical eyes [54.2%] vs 9 nonsurgical eyes [28.1%], P  = .048). CONCLUSIONS: Cataract surgery leads to vision improvement and does not appear to contribute to worsening of wet @entity9 . However, anatomic changes based on OCT analysis suggest a subclinical susceptibility to @entity3 macular @entity1 or exacerbation of @entity7 .

title: The effects of @entity4 surgery on XXXX with wet @entity6 .

answer: @entity0


abstract: BACKGROUND: The aim of this study was to evaluate the surgical outcomes and survival after gastrectomy in octogenarians and identify the optimal treatment for these @entity0 . METHODS: The medical records of 1262 @entity0 with @entity2 who underwent gastrectomy from January 2003 to December 2012 were reviewed retrospectively. @entity0 were divided into two age groups: octogenarians (>= 80  y, n  =  75) and nonoctogenarians (<80  y, n  =  1187). The @entity0 ' clinicopathologic data, surgical outcomes, and survival were evaluated. RESULTS: Octogenarians exhibited a higher proportion of female @entity0 , poorer performance scale scores, higher comorbidities, and more advanced @entity1 ( @entity1 ) stages than did nonoctogenarians. There was no difference in the surgical curability between the two groups, although octogenarians were more likely to have higher postoperative morbidity and mortality than those of nonoctogenarians. In an analysis of risk factors affecting survival after gastrectomy for octogenarians, only advanced @entity1 stage was an independent prognostic factor. Overall survival was significantly lower in octogenarians than in nonoctogenarians, whereas disease-specific survival was comparable between the two groups. There was no difference in the disease-specific survival for each stage of @entity1 after adjustment for @entity1 stage. CONCLUSIONS: Octogenarians had higher postoperative morbidity and mortality rates but comparable @entity1 -specific survival compared with nonoctogenarians. Only an advanced @entity1 stage influenced the prognosis of octogenarians. Early detection and thorough postoperative care would improve the overall survival for octogenarians with @entity2 .

title: Surgical outcomes and survival after gastrectomy in octogenarians with XXXX .

answer: @entity2


abstract: In the present experiments three different motion discrimination tasks were studied using a random dot pattern as stimulus: velocity discrimination, direction discrimination and discrimination of opposite directions. The analysis of the motion of random dot patterns is based on motion sensitive mechanisms without the confounding interference of position sensitive mechanisms (Nakayama and Tyler, 1981). Furthermore, since isotropic random dot patterns contain no dominant orientation, a change in the direction of motion does not parallel a change in orientation. Hence the use of a random dot pattern as stimulus allows velocity and direction discrimination to be compared. @entity0 velocity discrimination displays a U-shaped dependence on the stimulus velocity: the JNDs, expressed as Weber-fractions, are minimal for velocities ranging from 4 to 64 deg. @entity1 . The Weber-fractions in velocity, determined with a staircase procedure tracking a 84% correct response level, were about 7% at the optimal speeds. The velocity discrimination curve obtained with the random dot pattern is similar to that obtained with light bars. @entity0 direction discrimination, defined as the smallest difference in direction which can be resolved, also displays a U-shaped dependence on the stimulus velocity. Direction discrimination thresholds decrease up to a velocity of 4 deg. @entity1 , they then stay at a constant level up to 128 deg. @entity1 . Beyond this velocity the thresholds increase again. The mean direction discrimination threshold was 1.8 deg at optimal speeds. Discrimination of opposite directions, determined for the same conditions as those for which velocity and direction discrimination thresholds were determined, was better than the 90% response level at all speeds. However at low contrast, opposite directions are reliably discriminated only at intermediate speeds. Perceiving a coherent moving random dot pattern is supposed to be based on a cooperation between a large number of local motion detectors. In order to evaluate the importance of detector output pooling, the influence of the size of the pattern and of the presentation time on the three discrimination tasks was measured. The results indicate that the pooling requirements are task dependent. A somewhat larger pooling is required for velocity discrimination than for direction discrimination, whereas for discrimination of opposite directions only a few local motion detectors are involved.

title: XXXX velocity and direction discrimination measured with random dot patterns.

answer: @entity0


abstract: @entity0 monocyte-derived plasminogen activator inhibitor ( @entity8 ) was purified to homogeneity from the U937 cell line and partially sequenced. Oligonucleotide probes derived from this sequence were used to screen a cDNA library prepared from U937 cells. One positive clone was sequenced and contained most of the coding sequence as well as a long incomplete 3' untranslated region (1112 base pairs). This cDNA sequence was shown to encode @entity8 by hybrid-select translation. A cDNA clone encoding the remainder of the @entity8 mRNA was obtained by primer extension of U937 poly(A)+ RNA using a probe complementary to the @entity8 coding region. The coding sequence for @entity8 was placed under the control of the lambda PL promoter, and the protein expressed in @entity2 formed a complex with urokinase that could be detected immunologically. By @entity1 sequence analysis, @entity8 cDNA encodes a protein containing 415 @entity6 with a predicted unglycosylated Mr of 46,543. The predicted amino acid sequence of @entity8 is very similar to placental @entity9 (3 @entity3 differences) and shows extensive homology with members of the @entity4 protease inhibitor (serpin) superfamily. @entity8 was found to be more homologous to ovalbumin (37%) than the endothelial plasminogen activator inhibitor, @entity7 (26%). Like ovalbumin, @entity8 appears to have no typical @entity5 -terminal signal sequence. The 3' untranslated region of the @entity8 cDNA contains a putative regulatory sequence that has been associated with the inflammatory mediators.

title: Cloning and expression of a cDNA coding for a XXXX monocyte-derived plasminogen activator inhibitor.

answer: @entity0


abstract: Epidural spinal cord electrical stimulation (ESES) was performed on 10 @entity0 with severe @entity1 due to @entity3 . Microcirculatory parameters were assessed before and after ESES. Bright field microscopy was used to assess capillary diameters and red blood cell (RBC) velocity in the dorsum of the foot. @entity4 microscopy was used with intravenously injected @entity4 to study capillary density and @entity4 appearance time in the dorsum of the toe. The systolic ankle/arm pressure ratio and toe pressure measurements were used as macrocirculatory parameters. After ESES, clinical improvement was confirmed by intravital microscopy. Capillary density increased (p less than 0.001), RBC velocity in capillaries already perfused before ESES increased from 0.054 mm/sec to 0.762 mm/sec (p less than 0.001), and @entity4 appearance time decreased from 72 to 45 seconds (p less than 0.001). Capillary diameter did not change significantly so that the increase in RBC velocity may be interpreted as enhanced volume flow. Systolic ankle/arm pressure ratios and digital arterial pressure did not change significantly. The current results show that in @entity0 with @entity2 of the lower limbs, ESES recruits capillaries not perfused in the control situation and enhances skin blood flow, improvements that may explain the beneficial clinical effects of ESES.

title: Epidural spinal cord electrical stimulation improves microvascular blood flow in severe XXXX .

answer: @entity1


abstract: 1. The sensitivity of mesenteric resistance arterioles to [ @entity2 ]vasopressin ( @entity5 ) was investigated in spontaneously @entity1 @entity0 (SHR) and control @entity0 -Kyoto @entity0 (WKY). No difference in pAVP (-log dose of @entity5 producing 50% of the maximum response) was observed [SHR 0.21 +/- 0.03 m-units/ml (n = 10) vs WKY 0.15 +/- 0.06 m-units/ml (n = 9)], although SHR vessels exhibited greater absolute tension development. 2. Both strains of @entity0 displayed tachyphylaxis to repeated stimulation with @entity5 , and oscillatory tension changes were observed in all vessels from SHR and rarely in WKY vessels at activating concentrations of @entity5 . 3. @entity5 did not elicit a contractile response after @entity4 -induced @entity3 depletion. 4. After vessels were depleted of @entity3 by using a combination of @entity3 -free media and @entity4 stimulation, restoration of @entity3 in the presence of @entity5 elicited a greater contractile response in SHR vessels. 5. The results therefore provide evidence for an increased @entity3 response to @entity5 in SHR resistance vessels, although this was only demonstrable by @entity3 recovery experiments.

title: Vasopressin-mediated contractions in mesenteric arteries from spontaneously XXXX @entity0 : differences in response compared with @entity0 -Kyoto animals.

answer: @entity1


abstract: 1. The sensitivity of mesenteric resistance arterioles to [ @entity2 ]vasopressin ( @entity5 ) was investigated in spontaneously @entity1 @entity0 (SHR) and control @entity0 -Kyoto @entity0 (WKY). No difference in pAVP (-log dose of @entity5 producing 50% of the maximum response) was observed [SHR 0.21 +/- 0.03 m-units/ml (n = 10) vs WKY 0.15 +/- 0.06 m-units/ml (n = 9)], although SHR vessels exhibited greater absolute tension development. 2. Both strains of @entity0 displayed tachyphylaxis to repeated stimulation with @entity5 , and oscillatory tension changes were observed in all vessels from SHR and rarely in WKY vessels at activating concentrations of @entity5 . 3. @entity5 did not elicit a contractile response after @entity4 -induced @entity3 depletion. 4. After vessels were depleted of @entity3 by using a combination of @entity3 -free media and @entity4 stimulation, restoration of @entity3 in the presence of @entity5 elicited a greater contractile response in SHR vessels. 5. The results therefore provide evidence for an increased @entity3 response to @entity5 in SHR resistance vessels, although this was only demonstrable by @entity3 recovery experiments.

title: Vasopressin-mediated contractions in mesenteric arteries from spontaneously @entity1 XXXX : differences in response compared with @entity0 -Kyoto animals.

answer: @entity0