abstract: The objective of this work was to study the mechanism of @entity1 development under the influence of restriction of diet. Useful information is presented about the pathologic features associated with diet restriction in a @entity4 animal model of @entity3 . There were 96 @entity4 of two genotypes, Ross 308 and Cobb 500, in the experiment. The control group was fed a standard mixture ad libitum (ADL). The first experimental group, under restriction from the age of 2 weeks, was fed 80% ADL. The second experimental group was fed 65% ADL from the age of 2 weeks. There were 16 animals in each group. The experiment lasted 5 weeks. Liver parenchyma samples were obtained at the age of 35 days by the necropsy method and then processed by standard histologic methods. The slices were stained by standard staining: @entity5 - @entity6 and by Sirius red kit for collagen type I and reticulin visualization. Hepatocyte diameter and the proportion of interstitial tissue to the parenchyma of the liver were measured objectively. @entity2 was observed after 35 days of restriction. Hepatocyte diameter was significantly influenced by sex, genotype, and the experimental group. The proportion of interstitial tissue to the @entity1 was highly influenced by genotype and group, but there were no interactions. An increase in the @entity2 histologic grade is associated with inflammatory changes, with decrease of hepatocyte diameter and with a decreasing proportion of interstitial tissue to the @entity1 . The results show that early restriction is not associated with the development of @entity0 of the liver tissue.

title: Experimental study of @entity3 ( @entity3 ) on a model of starving @entity4 : is generalization of XXXX accompanied by @entity0 of the liver tissue?

answer: @entity2


abstract: The objective of this work was to study the mechanism of @entity1 development under the influence of restriction of diet. Useful information is presented about the pathologic features associated with diet restriction in a @entity4 animal model of @entity3 . There were 96 @entity4 of two genotypes, Ross 308 and Cobb 500, in the experiment. The control group was fed a standard mixture ad libitum (ADL). The first experimental group, under restriction from the age of 2 weeks, was fed 80% ADL. The second experimental group was fed 65% ADL from the age of 2 weeks. There were 16 animals in each group. The experiment lasted 5 weeks. Liver parenchyma samples were obtained at the age of 35 days by the necropsy method and then processed by standard histologic methods. The slices were stained by standard staining: @entity5 - @entity6 and by Sirius red kit for collagen type I and reticulin visualization. Hepatocyte diameter and the proportion of interstitial tissue to the parenchyma of the liver were measured objectively. @entity2 was observed after 35 days of restriction. Hepatocyte diameter was significantly influenced by sex, genotype, and the experimental group. The proportion of interstitial tissue to the @entity1 was highly influenced by genotype and group, but there were no interactions. An increase in the @entity2 histologic grade is associated with inflammatory changes, with decrease of hepatocyte diameter and with a decreasing proportion of interstitial tissue to the @entity1 . The results show that early restriction is not associated with the development of @entity0 of the liver tissue.

title: Experimental study of @entity3 ( @entity3 ) on a model of starving XXXX : is generalization of @entity2 accompanied by @entity0 of the liver tissue?

answer: @entity4


abstract: The objective of this work was to study the mechanism of @entity1 development under the influence of restriction of diet. Useful information is presented about the pathologic features associated with diet restriction in a @entity4 animal model of @entity3 . There were 96 @entity4 of two genotypes, Ross 308 and Cobb 500, in the experiment. The control group was fed a standard mixture ad libitum (ADL). The first experimental group, under restriction from the age of 2 weeks, was fed 80% ADL. The second experimental group was fed 65% ADL from the age of 2 weeks. There were 16 animals in each group. The experiment lasted 5 weeks. Liver parenchyma samples were obtained at the age of 35 days by the necropsy method and then processed by standard histologic methods. The slices were stained by standard staining: @entity5 - @entity6 and by Sirius red kit for collagen type I and reticulin visualization. Hepatocyte diameter and the proportion of interstitial tissue to the parenchyma of the liver were measured objectively. @entity2 was observed after 35 days of restriction. Hepatocyte diameter was significantly influenced by sex, genotype, and the experimental group. The proportion of interstitial tissue to the @entity1 was highly influenced by genotype and group, but there were no interactions. An increase in the @entity2 histologic grade is associated with inflammatory changes, with decrease of hepatocyte diameter and with a decreasing proportion of interstitial tissue to the @entity1 . The results show that early restriction is not associated with the development of @entity0 of the liver tissue.

title: Experimental study of XXXX ( @entity3 ) on a model of starving @entity4 : is generalization of @entity2 accompanied by @entity0 of the liver tissue?

answer: @entity3


abstract: The objective of this work was to study the mechanism of @entity1 development under the influence of restriction of diet. Useful information is presented about the pathologic features associated with diet restriction in a @entity4 animal model of @entity3 . There were 96 @entity4 of two genotypes, Ross 308 and Cobb 500, in the experiment. The control group was fed a standard mixture ad libitum (ADL). The first experimental group, under restriction from the age of 2 weeks, was fed 80% ADL. The second experimental group was fed 65% ADL from the age of 2 weeks. There were 16 animals in each group. The experiment lasted 5 weeks. Liver parenchyma samples were obtained at the age of 35 days by the necropsy method and then processed by standard histologic methods. The slices were stained by standard staining: @entity5 - @entity6 and by Sirius red kit for collagen type I and reticulin visualization. Hepatocyte diameter and the proportion of interstitial tissue to the parenchyma of the liver were measured objectively. @entity2 was observed after 35 days of restriction. Hepatocyte diameter was significantly influenced by sex, genotype, and the experimental group. The proportion of interstitial tissue to the @entity1 was highly influenced by genotype and group, but there were no interactions. An increase in the @entity2 histologic grade is associated with inflammatory changes, with decrease of hepatocyte diameter and with a decreasing proportion of interstitial tissue to the @entity1 . The results show that early restriction is not associated with the development of @entity0 of the liver tissue.

title: Experimental study of @entity3 ( XXXX ) on a model of starving @entity4 : is generalization of @entity2 accompanied by @entity0 of the liver tissue?

answer: @entity3


abstract: We evaluated a video prompting procedure to teach adults with @entity1 to take a digital photograph and print it using a laptop computer and a printer. @entity0 were four @entity0 with @entity1 . Training was conducted at the @entity0 ' residential facility. During baseline, @entity0 were told to take a photograph, but were given no other instruction. During intervention, @entity0 received instruction using a video prompting procedure. Video prompting consisted of watching a clip of each step of the task analysis and then having the opportunity to imitate that step. Video prompting was evaluated using a multiple-probe across @entity0 design. Following acquisition, video prompting was removed to assess maintenance at 2, 4 and 8 weeks and at 6 months. During naturalistic probes, @entity0 had the opportunity to take a picture of their choice of flora, surroundings or @entity0 . All four @entity0 learned to take and print a digital photograph with the video prompting procedures. The skills generalized to novel situations and were maintained at each follow-up probe. These data suggest that video prompting may be an effective instructional strategy for teaching digital photography skills to adults with @entity1 .

title: "Say Cheese": teaching photography skills to adults with XXXX .

answer: @entity1


abstract: OBJECTIVE: Although psychological and/or physiological stress has been well documented to influence immune responses, the precise mechanism for immunomodulation remains to be elucidated. The present work describes the role of the @entity6 in the mechanism of stress-mediated enhanced-resistance to lethality after lipopolysaccharide (LPS) injection. METHODS/RESULTS: Preconditioning with restraint stress (RS) resulted in enhanced activation of the @entity6 in response to LPS injection and suppressed LPS-induced release of proinflammatory cytokines and @entity5 metabolites. @entity9 -deficient @entity0 ( @entity9 (-/-)) failed to increase plasma levels of glucocorticoids in response to LPS injection, and exhibited high sensitivity to LPS-induced lethality with enhanced release of proinflammatory cytokines as compared with @entity9 (+/-) @entity0 . Real-time PCR analysis revealed that RS induced upregulation of @entity8 ( @entity8 ) in macrophages in the lung and the liver of @entity9 (+/-), but not of @entity9 (-/-), @entity0 . In addition, RS increased @entity8 -dependent uncoupling activity of isolated mitochondria from the liver of @entity9 (+/-), but not of @entity9 (-/-), @entity0 . In vitro study revealed that @entity7 and @entity3 directly increased @entity8 expression in @entity0 RAW 264.7 macrophages and suppressed the generation of LPS-induced mitochondrial reactive @entity1 species (ROS) and @entity4 production. Knockdown of @entity8 by small interfering RNA blunted the @entity3 action for suppressing LPS-induced mitochondrial ROS and @entity4 production. CONCLUSION: The present work suggests that RS enhances activation of the @entity6 to release glucocorticoids and upregulation of @entity8 in macrophages, thereby increasing the resistance to endotoxin-induced systemic @entity2 and death.    2015 S. Karger AG, Basel.

title: Stress-Induced Glucocorticoid Release Upregulates XXXX Expression and Enhances Resistance to Endotoxin-Induced Lethality.

answer: @entity8


abstract: INTRODUCTION: @entity0 with @entity4 present with liver @entity1 in 50-75% of cases at diagnosis. The aim of the present study was to assess prognostic factors in @entity0 with liver @entity1 from intestinal @entity2 after @entity2 surgical removal with or without liver surgery or radiofrequency ablation. The primary endpoint was disease-specific survival. METHODS: Data regarding seventy-eight consecutive @entity0 with liver @entity1 who undergone @entity2 surgical removal between 1996 and 2011 were extracted from the institutional @entity2 registry and retrospectively analyzed. RESULTS: @entity3 burden was <25% in 43 (55.1%) 25-50% in 30 (38.5%) and >50% in 5 (6.4%) @entity0 . For the whole cohort of @entity0 disease-specific survival at 3, 5 and 8 years was 93.2%, 83.6% and 77.3%, respectively. Fifteen @entity0 who underwent radical liver surgery were all alive with a median survival of 106 months (range 18-152 months). In multivariate analysis the Ki-67 index in a continuous fashion significantly correlate with prognosis (p  =  0.021). @entity3 burden (p  =  0.036) and extrahepatic involvement (p  =  0.03), were the most powerful prognosticators for @entity0 who underwent only debulking surgery. CONCLUSION: The Ki-67 index, the @entity3 burden and the presence of extrahepatic @entity1 should be carefully considered in the selection criteria for liver debulking in asymptomatic @entity0 .

title: XXXX with liver @entity1 and resection of the primary: Prognostic factors for decision making.

answer: @entity4


abstract: INTRODUCTION: @entity0 with @entity4 present with liver @entity1 in 50-75% of cases at diagnosis. The aim of the present study was to assess prognostic factors in @entity0 with liver @entity1 from intestinal @entity2 after @entity2 surgical removal with or without liver surgery or radiofrequency ablation. The primary endpoint was disease-specific survival. METHODS: Data regarding seventy-eight consecutive @entity0 with liver @entity1 who undergone @entity2 surgical removal between 1996 and 2011 were extracted from the institutional @entity2 registry and retrospectively analyzed. RESULTS: @entity3 burden was <25% in 43 (55.1%) 25-50% in 30 (38.5%) and >50% in 5 (6.4%) @entity0 . For the whole cohort of @entity0 disease-specific survival at 3, 5 and 8 years was 93.2%, 83.6% and 77.3%, respectively. Fifteen @entity0 who underwent radical liver surgery were all alive with a median survival of 106 months (range 18-152 months). In multivariate analysis the Ki-67 index in a continuous fashion significantly correlate with prognosis (p  =  0.021). @entity3 burden (p  =  0.036) and extrahepatic involvement (p  =  0.03), were the most powerful prognosticators for @entity0 who underwent only debulking surgery. CONCLUSION: The Ki-67 index, the @entity3 burden and the presence of extrahepatic @entity1 should be carefully considered in the selection criteria for liver debulking in asymptomatic @entity0 .

title: @entity4 with liver XXXX and resection of the primary: Prognostic factors for decision making.

answer: @entity1


abstract: BACKGROUND: A Korean version of Toronto Extremity Salvage Score (TESS), a widely used disease-specific @entity0 -reported questionnaire for assessing physical function of @entity1 @entity0 , has not been developed. OBJECTIVES: 1) to translate and cross-culturally adapt the TESS into Korean, and 2) to examine its comprehensibility, reliability and validity. METHODS: TESS was translated into Korean, then translated back into English, and reviewed by a committee to develop the consensus version of the Korean TESS. The Korean TESS was administered to 126 @entity0 to examine its comprehensibility, reliability, and validity. RESULTS: Comprehensibility was high, as the @entity0 rated questions as "easy" or "very easy" in 96% for the TESS lower extremity (LE) and in 97% for the TESS upper extremity (UE). Test-retest reliability with intraclass coefficient (0.874 for LE and 0.979 for UE) and internal consistency with Cronbach's alpha (0.978 for LE and 0.989 for UE) were excellent. Korean TESS correlated with the MSTS score (r   =   0.772 for LE and r   =   0.635 for UE), and physical functioning domain of EORTC-CLQ C30 (r   =   0.840 for LE and r   =   0.630 for UE). CONCLUSION: Our study suggests that Korean version of the TESS is a comprehensible, reliable, and valid instrument to measure @entity0 -reported functional outcome in @entity0 with extremity @entity1 . J. Surg. Oncol. 2015 111:93-97.    2015 Wiley Periodicals, Inc.

title: Cross-cultural adaptation and validation of the Korean Toronto Extremity Salvage Score for extremity XXXX .

answer: @entity1


abstract: @entity4 follows a @entity2 in blood flow to the intestine. Absence of a practical diagnostic test results in delayed diagnosis and inability to evaluate changes in blood flow due to vasodilator therapy. We recorded the disappearance of radioxenon (133Xe) from @entity0 bowel to quantitate the decreased perfusion and to assess changes in submucosal blood flow after intra-arterial @entity3 . The @entity0 colon, its only blood supply from collaterals, was formed into a Thirty-Vella loop. An infusion catheter placed at the origin of the superior mesenteric artery (SMA) was used to deliver saline or @entity3 (0.1 mg./kg./min). Eleven control @entity1 received N.S. only. In nine @entity1 @entity3 infusion was started immediately and in another 12 @entity1 two hours after the production of @entity0 . Submucosal blood flow was determined by the per cent washout at two minutes of an 0.05 ml. injection of 133Xe dissolved in N.S., made into the submucosal space of the colostomy.

title: Radioxenon washout for evaluation of vasodilator therapy in XXXX .

answer: @entity4


abstract: OBJECTIVE: To investigate the association between muscle perfusion in the peri-articular knee muscles assessed by dynamic contrast enhanced magnetic resonance imaging ( @entity5 -MRI) and symptoms in @entity0 with @entity3 ( @entity3 ). DESIGN: In a cross-sectional setting, muscle perfusion was quantified by @entity5 -MRI in @entity3 . Regions of interest (ROI) were drawn around the peri-articular muscles, summed and averaged into one single "Total Muscle Volume" volume of interest (VOI). Symptoms were assessed via the @entity4 and @entity2 Outcome Score (KOOS) (0: worst; 100: best). RESULTS: @entity5 -MRI and clinical data were analyzed in 94 @entity0 . The typical @entity0 was a @entity0 with a mean age of 65 years, and a body mass index (BMI) of 32  kg/m(2). Reduced multiple regression models analyzing the association between KOOS and @entity5 -MRI perfusion variables of Total Muscle Volume showed a statistically significant association between Nvoxel% and KOOS @entity1 (0.41 (SE 0.14); P  =  0.0048). Nvoxel% was defined as the proportion of highly perfused voxels; i.e., the voxels that show an early and rapid increase on the signal intensity vs time curves, reach a plateau state (plateau pattern) and then showing a relatively rapid decline (washout pattern) relative to the total number of voxels within the muscle VOI. CONCLUSIONS: More widespread perfusion in the peri-articular knee muscles was associated with @entity1 in @entity0 with @entity3 . These results give rise to investigations of the effects of exercise on muscle perfusion and its possible mediating role in the causal pathway between exercise and @entity1 improvements in the conservative management of @entity3 .

title: Associations between muscle perfusion and symptoms in XXXX : a cross sectional study.

answer: @entity3


abstract: The aim of this study was to examine the interaction of Notch/Notch ligand with Th17/Treg, cytokines IL-35 and @entity3 in cases of @entity2 ( @entity2 ). Methods. Peripheral blood was obtained from 42 @entity2 @entity0 and 22 health pregnant @entity0 . The mRNA expressions of Notch/Notch ligand, Treg transcription factor @entity1 and Th17 transcription factor RORyt, @entity5 and @entity4 (IL-35 two subunits), and @entity3 were determined by qPCR. The serum levels of @entity3 and IL-35 were measured by ELISA. Results. It was observed that the expressions of @entity1 , @entity5 , and @entity4 in @entity2 @entity0 were lower compared with normal pregnancy, whereas the RORyt expression was significantly increased. The results also demonstrated that @entity2 @entity0 exhibited decreased levels of Treg-related cytokine IL-35, whereas @entity3 was significantly increased. @entity2 @entity0 expressed higher levels of Notch receptor (1-4) and Notch ligand of @entity7 , whereas Notch ligand of @entity8 was much lower. Furthermore, the levels of @entity1 T cells correlated positively with @entity6 . In addition, there were positive correlations between the mRNA level of @entity3 and @entity7 . Conclusion. Our results indicated that maternal immunological changes may reverse maternal tolerance in @entity2 , and this phenomenon may due to the Th17/Treg imbalance affected by Notch/Notch ligand.

title: The Expression of Notch/Notch Ligand, IL-35, XXXX , and Th17/Treg in Preeclampsia.

answer: @entity3


abstract: AIM: To investigate the utility of @entity5 ( @entity5 ) using @entity10 ( @entity10 ) to detect @entity3 . METHODS: This prospective single-center study investigated inter-subject variability in @entity0 with early-stage @entity3 indicated for endoscopic resection. Subjects were @entity0 with @entity3 who had undergone endoscopic resection between November 2012 and November 2013. Selection criteria included age 20-80 years, either sex, and provision of informed consent. @entity0 were orally administered 20 mg/kg of @entity10 enteric-coated capsules (SBI ALApromo Co., Tokyo, Japan). Administration of @entity10 was followed by endoscopic resection of @entity3 , and the resected specimens were examined using a video autofluorescence processor and a fluorescence endoscope (SAFE-3000 and EB-1970AK, respectively; Pentax, Tokyo, Japan). The primary endpoint was the presence of fluorescence in @entity2 . Endoscopic, macroscopic, and histopathologic findings of @entity2 were assessed. We also evaluated adverse events of the present procedure as a secondary endpoint and examined each @entity0 for the presence of known adverse effects of @entity10 , namely, hematocytopenia, @entity7 , @entity8 , @entity6 , and photosensitivity. RESULTS: We enrolled 10 @entity0 (7 @entity0 , 3 @entity0 ) (n = 13 lesions: 10 gastric/3 @entity3 ). Fluorescence was detected in 7/13 (53.8%) lesions. No significant differences in sex (male: 55.6% vs female: 50.5%, P = 1.00), age (67.1    1.9 years vs 65.0    2.0 years, P = 0.45), @entity2 color (reddish: 60.0% vs discolored: 33.3%, P = 0.56), @entity2 diameter (15.0    2.1 mm vs 14.2    2.3 mm, P = 0.80), macroscopic type (protruded: 70.0% vs depressed 0%, P = 0.07), histologic type (differentiated type: 58.3% vs 0%, P = 0.46), invasion depth (mucosal layer: 55.6% vs submucosal layer: 33.3%, P = 1.00), lymphatic invasion (present: 33.3% vs absent: 50.0%, P = 1.00), @entity1 (present: 0% vs absent: 54.5%, P = 1.00) or procedure time of endoscopic resection (36.3    8.3 min vs 36.7    9.0 min, P = 0.98) were observed between the @entity0 with and without fluorescence. Fluorescence detection rate tended to be high for @entity4 . @entity7 developed in 4/10 (40.0%) @entity0 . The extent of the @entity7 was a slight increase in transaminases and total @entity9 levels, which spontaneously improved in the @entity0 . None of the @entity0 developed photosensitivity. CONCLUSION: Results of this preliminary study suggest the utility of @entity5 using @entity10 for screening of @entity3 .

title: Preliminary study of @entity5 using XXXX in gastric and @entity3 .

answer: @entity10


abstract: AIM: To investigate the utility of @entity5 ( @entity5 ) using @entity10 ( @entity10 ) to detect @entity3 . METHODS: This prospective single-center study investigated inter-subject variability in @entity0 with early-stage @entity3 indicated for endoscopic resection. Subjects were @entity0 with @entity3 who had undergone endoscopic resection between November 2012 and November 2013. Selection criteria included age 20-80 years, either sex, and provision of informed consent. @entity0 were orally administered 20 mg/kg of @entity10 enteric-coated capsules (SBI ALApromo Co., Tokyo, Japan). Administration of @entity10 was followed by endoscopic resection of @entity3 , and the resected specimens were examined using a video autofluorescence processor and a fluorescence endoscope (SAFE-3000 and EB-1970AK, respectively; Pentax, Tokyo, Japan). The primary endpoint was the presence of fluorescence in @entity2 . Endoscopic, macroscopic, and histopathologic findings of @entity2 were assessed. We also evaluated adverse events of the present procedure as a secondary endpoint and examined each @entity0 for the presence of known adverse effects of @entity10 , namely, hematocytopenia, @entity7 , @entity8 , @entity6 , and photosensitivity. RESULTS: We enrolled 10 @entity0 (7 @entity0 , 3 @entity0 ) (n = 13 lesions: 10 gastric/3 @entity3 ). Fluorescence was detected in 7/13 (53.8%) lesions. No significant differences in sex (male: 55.6% vs female: 50.5%, P = 1.00), age (67.1    1.9 years vs 65.0    2.0 years, P = 0.45), @entity2 color (reddish: 60.0% vs discolored: 33.3%, P = 0.56), @entity2 diameter (15.0    2.1 mm vs 14.2    2.3 mm, P = 0.80), macroscopic type (protruded: 70.0% vs depressed 0%, P = 0.07), histologic type (differentiated type: 58.3% vs 0%, P = 0.46), invasion depth (mucosal layer: 55.6% vs submucosal layer: 33.3%, P = 1.00), lymphatic invasion (present: 33.3% vs absent: 50.0%, P = 1.00), @entity1 (present: 0% vs absent: 54.5%, P = 1.00) or procedure time of endoscopic resection (36.3    8.3 min vs 36.7    9.0 min, P = 0.98) were observed between the @entity0 with and without fluorescence. Fluorescence detection rate tended to be high for @entity4 . @entity7 developed in 4/10 (40.0%) @entity0 . The extent of the @entity7 was a slight increase in transaminases and total @entity9 levels, which spontaneously improved in the @entity0 . None of the @entity0 developed photosensitivity. CONCLUSION: Results of this preliminary study suggest the utility of @entity5 using @entity10 for screening of @entity3 .

title: Preliminary study of @entity5 using @entity10 in gastric and XXXX .

answer: @entity3


abstract: AIM: To investigate the utility of @entity5 ( @entity5 ) using @entity10 ( @entity10 ) to detect @entity3 . METHODS: This prospective single-center study investigated inter-subject variability in @entity0 with early-stage @entity3 indicated for endoscopic resection. Subjects were @entity0 with @entity3 who had undergone endoscopic resection between November 2012 and November 2013. Selection criteria included age 20-80 years, either sex, and provision of informed consent. @entity0 were orally administered 20 mg/kg of @entity10 enteric-coated capsules (SBI ALApromo Co., Tokyo, Japan). Administration of @entity10 was followed by endoscopic resection of @entity3 , and the resected specimens were examined using a video autofluorescence processor and a fluorescence endoscope (SAFE-3000 and EB-1970AK, respectively; Pentax, Tokyo, Japan). The primary endpoint was the presence of fluorescence in @entity2 . Endoscopic, macroscopic, and histopathologic findings of @entity2 were assessed. We also evaluated adverse events of the present procedure as a secondary endpoint and examined each @entity0 for the presence of known adverse effects of @entity10 , namely, hematocytopenia, @entity7 , @entity8 , @entity6 , and photosensitivity. RESULTS: We enrolled 10 @entity0 (7 @entity0 , 3 @entity0 ) (n = 13 lesions: 10 gastric/3 @entity3 ). Fluorescence was detected in 7/13 (53.8%) lesions. No significant differences in sex (male: 55.6% vs female: 50.5%, P = 1.00), age (67.1    1.9 years vs 65.0    2.0 years, P = 0.45), @entity2 color (reddish: 60.0% vs discolored: 33.3%, P = 0.56), @entity2 diameter (15.0    2.1 mm vs 14.2    2.3 mm, P = 0.80), macroscopic type (protruded: 70.0% vs depressed 0%, P = 0.07), histologic type (differentiated type: 58.3% vs 0%, P = 0.46), invasion depth (mucosal layer: 55.6% vs submucosal layer: 33.3%, P = 1.00), lymphatic invasion (present: 33.3% vs absent: 50.0%, P = 1.00), @entity1 (present: 0% vs absent: 54.5%, P = 1.00) or procedure time of endoscopic resection (36.3    8.3 min vs 36.7    9.0 min, P = 0.98) were observed between the @entity0 with and without fluorescence. Fluorescence detection rate tended to be high for @entity4 . @entity7 developed in 4/10 (40.0%) @entity0 . The extent of the @entity7 was a slight increase in transaminases and total @entity9 levels, which spontaneously improved in the @entity0 . None of the @entity0 developed photosensitivity. CONCLUSION: Results of this preliminary study suggest the utility of @entity5 using @entity10 for screening of @entity3 .

title: Preliminary study of XXXX using @entity10 in gastric and @entity3 .

answer: @entity5


abstract: We recorded activity of @entity2 (DA) neurons in the substantia nigra pars compacta in unrestrained @entity0 while monitoring their movements with video tracking. Our approach allows an unbiased examination of the continuous relationship between single unit activity and behavior. Although DA neurons show characteristic burst firing following cue or reward presentation, as previously reported, their activity can be explained by the representation of actual movement kinematics. Unlike neighboring pars reticulata GABAergic output neurons, which can represent vector components of position, DA neurons represent vector components of velocity or acceleration. We found neurons related to movements in four directions-up, down, left, right. For horizontal movements, there is significant lateralization of neurons: the left nigra contains more rightward neurons, whereas the right nigra contains more leftward neurons. The relationship between DA activity and movement kinematics was found on both appetitive trials using @entity3 and aversive trials using air puff, showing that these neurons belong to a velocity control circuit that can be used for any number of purposes, whether to seek reward or to avoid harm. In support of this conclusion, mimicry of the phasic activation of DA neurons with selective optogenetic stimulation could also generate movements. Contrary to the popular hypothesis that DA neurons encode reward prediction errors, our results suggest that nigrostriatal DA plays an essential role in controlling the kinematics of @entity1 . We hypothesize that DA signaling implements gain adjustment for adaptive transition control, and describe a new model of the basal ganglia (BG) in which DA functions to adjust the gain of the transition controller. This model has significant implications for our understanding of @entity1 implicating DA and the BG.

title: Beyond reward prediction errors: the role of XXXX in movement kinematics.

answer: @entity2


abstract: We aim to study the association between @entity7 and in-hospital outcomes among @entity0 with moderate and severe @entity2 ( @entity2 ). This retrospective cohort study was conducted in a tertiary pediatric hospital between 2003 and 2013. All @entity0 < 16 years old who presented to the Emergency Department within 24 hours of @entity5 with a Glasgow @entity6 Scale (GCS)  <= 13 were included. Our outcomes of interest were @entity3 , 14 ventilation-free, 14 pediatric intensive care unit- (PICU-) free, and 28 hospital-free days. @entity7 was defined as @entity4 > 200   mg/dL (11.1   mmol/L). Among the 44 @entity0 analyzed, the median age was 8.6 years (interquartile range (IQR) 5.0-11.0). Median GCS and pediatric @entity1 scores were 7 (IQR 4-10) and 4 (IQR 3-6), respectively. Initial @entity7 was associated with @entity3 (37% in the @entity7 group versus 8% in the normoglycemia group, p = 0.019), reduced median PICU-free days (6 days versus 11 days, p = 0.006), and reduced median ventilation-free days (8 days versus 12 days, p = 0.008). This association was however not significant in the stratified analysis of @entity0 with GCS  <= 8. Conclusion. Our findings demonstrate that early @entity7 is associated with increased mortality, prolonged duration of mechanical ventilation, and PICU stay in @entity0 with @entity2 .

title: Early @entity7 in Pediatric XXXX Predicts for Mortality, Prolonged Duration of Mechanical Ventilation, and Intensive Care Stay.

answer: @entity2


abstract: We aim to study the association between @entity7 and in-hospital outcomes among @entity0 with moderate and severe @entity2 ( @entity2 ). This retrospective cohort study was conducted in a tertiary pediatric hospital between 2003 and 2013. All @entity0 < 16 years old who presented to the Emergency Department within 24 hours of @entity5 with a Glasgow @entity6 Scale (GCS)  <= 13 were included. Our outcomes of interest were @entity3 , 14 ventilation-free, 14 pediatric intensive care unit- (PICU-) free, and 28 hospital-free days. @entity7 was defined as @entity4 > 200   mg/dL (11.1   mmol/L). Among the 44 @entity0 analyzed, the median age was 8.6 years (interquartile range (IQR) 5.0-11.0). Median GCS and pediatric @entity1 scores were 7 (IQR 4-10) and 4 (IQR 3-6), respectively. Initial @entity7 was associated with @entity3 (37% in the @entity7 group versus 8% in the normoglycemia group, p = 0.019), reduced median PICU-free days (6 days versus 11 days, p = 0.006), and reduced median ventilation-free days (8 days versus 12 days, p = 0.008). This association was however not significant in the stratified analysis of @entity0 with GCS  <= 8. Conclusion. Our findings demonstrate that early @entity7 is associated with increased mortality, prolonged duration of mechanical ventilation, and PICU stay in @entity0 with @entity2 .

title: Early XXXX in Pediatric @entity2 Predicts for Mortality, Prolonged Duration of Mechanical Ventilation, and Intensive Care Stay.

answer: @entity7


abstract: Split hand-split food @entity3 (SHFM) is a @entity1 of limb development that involves the central rays of the autopod and presents with median clefts of the hands and feet. It often includes syndactyly and @entity6 / @entity2 of the phalanges. SHFM is a @entity0 with high genetic heterogeneity, with at least 6 associated chromosomal loci. A locus in chromosomal region 7q21.3, associated with SHFM is referred to as @entity8 . Genes considered to be associated with @entity8 are @entity9 and @entity7 . These two genes participate in the Wnt pathway that has a role in limb development. The gene @entity10 , located proximally (centromeric) to the @entity8 locus was recently reported to include enhancer sequences involved in limb development in its exons 15 and 17. These sequences were shown to cis-regulate the function of the adjacent SHFM associated genes. We report a family, in which the father and three of his sons carry an approximately 1  Mb deletion in this chromosomal region, arr[hg19]7q21.3(94,769,383-95,801,045)x1. The deleted region is located proximally (centromerically) adjacent to the SHFM region at 7q21.3. It does not include the SHFM candidate genes @entity9 and @entity7 , but includes the enhancer sequences within DYNC111 and six other genes centromeric to @entity10 . All deletion carriers have various degrees of @entity4 while two of them have SHFM. This family is the eighth reported family where a chromosome 7q21.3 deletion co-segregating with SHFM involves the enhancer regions within gene DYNC111, but does not involve the genes @entity9 and @entity7 . This is also the third family where decreased penetrance of enhancer-associated SHFM is demonstrated. @entity4 was not observed in the previously reported families and may be associated with @entity5 or more of the 6 genes included in the reported deletion centromeric to @entity10 .

title: 7q21.3 Deletion involving enhancer sequences within the gene XXXX presents with @entity4 and split hand-split foot @entity3 with decreased penetrance.

answer: @entity10


abstract: Split hand-split food @entity3 (SHFM) is a @entity1 of limb development that involves the central rays of the autopod and presents with median clefts of the hands and feet. It often includes syndactyly and @entity6 / @entity2 of the phalanges. SHFM is a @entity0 with high genetic heterogeneity, with at least 6 associated chromosomal loci. A locus in chromosomal region 7q21.3, associated with SHFM is referred to as @entity8 . Genes considered to be associated with @entity8 are @entity9 and @entity7 . These two genes participate in the Wnt pathway that has a role in limb development. The gene @entity10 , located proximally (centromeric) to the @entity8 locus was recently reported to include enhancer sequences involved in limb development in its exons 15 and 17. These sequences were shown to cis-regulate the function of the adjacent SHFM associated genes. We report a family, in which the father and three of his sons carry an approximately 1  Mb deletion in this chromosomal region, arr[hg19]7q21.3(94,769,383-95,801,045)x1. The deleted region is located proximally (centromerically) adjacent to the SHFM region at 7q21.3. It does not include the SHFM candidate genes @entity9 and @entity7 , but includes the enhancer sequences within DYNC111 and six other genes centromeric to @entity10 . All deletion carriers have various degrees of @entity4 while two of them have SHFM. This family is the eighth reported family where a chromosome 7q21.3 deletion co-segregating with SHFM involves the enhancer regions within gene DYNC111, but does not involve the genes @entity9 and @entity7 . This is also the third family where decreased penetrance of enhancer-associated SHFM is demonstrated. @entity4 was not observed in the previously reported families and may be associated with @entity5 or more of the 6 genes included in the reported deletion centromeric to @entity10 .

title: 7q21.3 Deletion involving enhancer sequences within the gene @entity10 presents with @entity4 and split hand-split foot XXXX with decreased penetrance.

answer: @entity3


abstract: Split hand-split food @entity3 (SHFM) is a @entity1 of limb development that involves the central rays of the autopod and presents with median clefts of the hands and feet. It often includes syndactyly and @entity6 / @entity2 of the phalanges. SHFM is a @entity0 with high genetic heterogeneity, with at least 6 associated chromosomal loci. A locus in chromosomal region 7q21.3, associated with SHFM is referred to as @entity8 . Genes considered to be associated with @entity8 are @entity9 and @entity7 . These two genes participate in the Wnt pathway that has a role in limb development. The gene @entity10 , located proximally (centromeric) to the @entity8 locus was recently reported to include enhancer sequences involved in limb development in its exons 15 and 17. These sequences were shown to cis-regulate the function of the adjacent SHFM associated genes. We report a family, in which the father and three of his sons carry an approximately 1  Mb deletion in this chromosomal region, arr[hg19]7q21.3(94,769,383-95,801,045)x1. The deleted region is located proximally (centromerically) adjacent to the SHFM region at 7q21.3. It does not include the SHFM candidate genes @entity9 and @entity7 , but includes the enhancer sequences within DYNC111 and six other genes centromeric to @entity10 . All deletion carriers have various degrees of @entity4 while two of them have SHFM. This family is the eighth reported family where a chromosome 7q21.3 deletion co-segregating with SHFM involves the enhancer regions within gene DYNC111, but does not involve the genes @entity9 and @entity7 . This is also the third family where decreased penetrance of enhancer-associated SHFM is demonstrated. @entity4 was not observed in the previously reported families and may be associated with @entity5 or more of the 6 genes included in the reported deletion centromeric to @entity10 .

title: 7q21.3 Deletion involving enhancer sequences within the gene @entity10 presents with XXXX and split hand-split foot @entity3 with decreased penetrance.

answer: @entity4


abstract: Neoadjuvant @entity5 for @entity1 ( @entity1 ) is increasingly used nowadays. As oesophagectomy is associated with high morbidity and mortality, a preoperative downsizing of an oesophageal @entity3 to limit the extent of resection would be ideal. Because these @entity1 are rare and neoadjuvant treatment with @entity5 is recent, there is limited literature available regarding neoadjuvant administration of @entity5 in @entity0 with oesophageal @entity1 . A 50-year-old @entity0 presented with total @entity4 . An upper endoscopy and biopsy revealed a large submucosal KIT-positive @entity3 obstructing the mid oesophagus. CT confirmed a lesion measuring 99   mm * 50   mm * 104   mm. Because the size and location of the @entity1 increased the risk of intraoperative @entity2 , it was decided to administer preoperative @entity5 . The @entity0 had an excellent clinical and radiological response. Her @entity4 gradually resolved and the follow-up CT scans of the first 10 months showed a gradually reducing @entity1 size to 54   mm * 33   mm * 42   mm. The @entity0 underwent an uneventful laparoscopic-assisted Ivor-Lewis oesophagectomy. Postoperatively, the @entity0 continued with adjuvant @entity5 . At the last follow-up, 1 year from operation and 38 months from the diagnosis, the @entity0 is disease free.

title: Effective Downsizing of a Large Oesophageal Gastrointestinal Stromal @entity1 with Neoadjuvant @entity5 Enabling an Uncomplicated and without XXXX Rupture Laparoscopic-Assisted Ivor-Lewis Oesophagectomy.

answer: @entity1


abstract: Neoadjuvant @entity5 for @entity1 ( @entity1 ) is increasingly used nowadays. As oesophagectomy is associated with high morbidity and mortality, a preoperative downsizing of an oesophageal @entity3 to limit the extent of resection would be ideal. Because these @entity1 are rare and neoadjuvant treatment with @entity5 is recent, there is limited literature available regarding neoadjuvant administration of @entity5 in @entity0 with oesophageal @entity1 . A 50-year-old @entity0 presented with total @entity4 . An upper endoscopy and biopsy revealed a large submucosal KIT-positive @entity3 obstructing the mid oesophagus. CT confirmed a lesion measuring 99   mm * 50   mm * 104   mm. Because the size and location of the @entity1 increased the risk of intraoperative @entity2 , it was decided to administer preoperative @entity5 . The @entity0 had an excellent clinical and radiological response. Her @entity4 gradually resolved and the follow-up CT scans of the first 10 months showed a gradually reducing @entity1 size to 54   mm * 33   mm * 42   mm. The @entity0 underwent an uneventful laparoscopic-assisted Ivor-Lewis oesophagectomy. Postoperatively, the @entity0 continued with adjuvant @entity5 . At the last follow-up, 1 year from operation and 38 months from the diagnosis, the @entity0 is disease free.

title: Effective Downsizing of a Large Oesophageal Gastrointestinal Stromal XXXX with Neoadjuvant @entity5 Enabling an Uncomplicated and without @entity1 Rupture Laparoscopic-Assisted Ivor-Lewis Oesophagectomy.

answer: @entity1


abstract: Neoadjuvant @entity5 for @entity1 ( @entity1 ) is increasingly used nowadays. As oesophagectomy is associated with high morbidity and mortality, a preoperative downsizing of an oesophageal @entity3 to limit the extent of resection would be ideal. Because these @entity1 are rare and neoadjuvant treatment with @entity5 is recent, there is limited literature available regarding neoadjuvant administration of @entity5 in @entity0 with oesophageal @entity1 . A 50-year-old @entity0 presented with total @entity4 . An upper endoscopy and biopsy revealed a large submucosal KIT-positive @entity3 obstructing the mid oesophagus. CT confirmed a lesion measuring 99   mm * 50   mm * 104   mm. Because the size and location of the @entity1 increased the risk of intraoperative @entity2 , it was decided to administer preoperative @entity5 . The @entity0 had an excellent clinical and radiological response. Her @entity4 gradually resolved and the follow-up CT scans of the first 10 months showed a gradually reducing @entity1 size to 54   mm * 33   mm * 42   mm. The @entity0 underwent an uneventful laparoscopic-assisted Ivor-Lewis oesophagectomy. Postoperatively, the @entity0 continued with adjuvant @entity5 . At the last follow-up, 1 year from operation and 38 months from the diagnosis, the @entity0 is disease free.

title: Effective Downsizing of a Large Oesophageal Gastrointestinal Stromal @entity1 with Neoadjuvant XXXX Enabling an Uncomplicated and without @entity1 Rupture Laparoscopic-Assisted Ivor-Lewis Oesophagectomy.

answer: @entity5


abstract: Background. @entity5 is a rare @entity1 similar to fetal lung tissues. Surgical resection at early stage is more curative than other treatments, but there is no standard treatment in unresectable cases. We show a case treated with @entity4 and @entity3 plus bevacizumab. Case. A 68-year-old @entity0 received surgical resection and was diagnosed with @entity5 (pT3N0M0 stage IIB). @entity2 to the spleen was detected six weeks after the surgery. @entity4 , @entity3 , and bevacizumab were administered and showed an effect on the @entity2 . Four courses of the chemotherapy were completed, but a @entity2 was found and the @entity2 in the spleen was enlarged. After that, chemotherapy was not effective afterward and he died of the progression of @entity5 on the 292nd day of illness. Conclusion. In this case, chemotherapy with @entity4 and @entity3 plus bevacizumab was temporarily efficacious for @entity5 .

title: A Case of @entity5 Treated with XXXX and @entity3 plus Bevacizumab.

answer: @entity4


abstract: Background. @entity5 is a rare @entity1 similar to fetal lung tissues. Surgical resection at early stage is more curative than other treatments, but there is no standard treatment in unresectable cases. We show a case treated with @entity4 and @entity3 plus bevacizumab. Case. A 68-year-old @entity0 received surgical resection and was diagnosed with @entity5 (pT3N0M0 stage IIB). @entity2 to the spleen was detected six weeks after the surgery. @entity4 , @entity3 , and bevacizumab were administered and showed an effect on the @entity2 . Four courses of the chemotherapy were completed, but a @entity2 was found and the @entity2 in the spleen was enlarged. After that, chemotherapy was not effective afterward and he died of the progression of @entity5 on the 292nd day of illness. Conclusion. In this case, chemotherapy with @entity4 and @entity3 plus bevacizumab was temporarily efficacious for @entity5 .

title: A Case of XXXX Treated with @entity4 and @entity3 plus Bevacizumab.

answer: @entity5


abstract: Background. @entity5 is a rare @entity1 similar to fetal lung tissues. Surgical resection at early stage is more curative than other treatments, but there is no standard treatment in unresectable cases. We show a case treated with @entity4 and @entity3 plus bevacizumab. Case. A 68-year-old @entity0 received surgical resection and was diagnosed with @entity5 (pT3N0M0 stage IIB). @entity2 to the spleen was detected six weeks after the surgery. @entity4 , @entity3 , and bevacizumab were administered and showed an effect on the @entity2 . Four courses of the chemotherapy were completed, but a @entity2 was found and the @entity2 in the spleen was enlarged. After that, chemotherapy was not effective afterward and he died of the progression of @entity5 on the 292nd day of illness. Conclusion. In this case, chemotherapy with @entity4 and @entity3 plus bevacizumab was temporarily efficacious for @entity5 .

title: A Case of @entity5 Treated with @entity4 and XXXX plus Bevacizumab.

answer: @entity3


abstract: INTRODUCTION: Transurethral resection of @entity2 (TURBT) is a common procedure used in the diagnosis and treatment of @entity2 . Despite how often it is performed, not much is known about the risk factors for complications. Traditional surgery has an increase in morbidity and mortality with increasing operative duration. We assess the effect of operative duration on TURBT complications. METHODS: The years 2006 to 2012 of the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) were queried for @entity0 undergoing TURBT. We separated @entity0 into 4 groups based on operative time: 0 to 30 minutes, 30.1 to 60 minutes, 60.1 to 90 minutes, and greater than 90 minutes. Standard statistical analysis including multivariate regression was performed to determine predictors of complications. RESULTS: A total of 10,599 TURBTs were included in our analysis. The overall complication rate for TURBT was 5.8% and there was an increase in the rate of complications seen as operative duration increased, which remained after controlling for age, comorbidities, @entity1 size, and American Society of Anesthesiology classification. Increased operative duration was associated with a greater risk of @entity5 , @entity6 or @entity7 , @entity10 / @entity9 , reintubation or failure to wean, @entity8 , and @entity3 . @entity1 were related to an increased odds of requiring blood transfusions. CONCLUSIONS: Using a contemporary multicenter cohort of TURBTs from the ACS NSQIP database, we demonstrate that increased operative duration is associated with serious @entity4 . This association was found to persist even after adjusting for @entity0 age, comorbidities, @entity1 size, and functional status.

title: The effect of surgical duration of transurethral resection of XXXX on @entity4 : An analysis of ACS NSQIP data.

answer: @entity2


abstract: INTRODUCTION: Transurethral resection of @entity2 (TURBT) is a common procedure used in the diagnosis and treatment of @entity2 . Despite how often it is performed, not much is known about the risk factors for complications. Traditional surgery has an increase in morbidity and mortality with increasing operative duration. We assess the effect of operative duration on TURBT complications. METHODS: The years 2006 to 2012 of the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) were queried for @entity0 undergoing TURBT. We separated @entity0 into 4 groups based on operative time: 0 to 30 minutes, 30.1 to 60 minutes, 60.1 to 90 minutes, and greater than 90 minutes. Standard statistical analysis including multivariate regression was performed to determine predictors of complications. RESULTS: A total of 10,599 TURBTs were included in our analysis. The overall complication rate for TURBT was 5.8% and there was an increase in the rate of complications seen as operative duration increased, which remained after controlling for age, comorbidities, @entity1 size, and American Society of Anesthesiology classification. Increased operative duration was associated with a greater risk of @entity5 , @entity6 or @entity7 , @entity10 / @entity9 , reintubation or failure to wean, @entity8 , and @entity3 . @entity1 were related to an increased odds of requiring blood transfusions. CONCLUSIONS: Using a contemporary multicenter cohort of TURBTs from the ACS NSQIP database, we demonstrate that increased operative duration is associated with serious @entity4 . This association was found to persist even after adjusting for @entity0 age, comorbidities, @entity1 size, and functional status.

title: The effect of surgical duration of transurethral resection of @entity2 on XXXX : An analysis of ACS NSQIP data.

answer: @entity4


abstract: BACKGROUND: No study has applied the "fat-but-fit" paradigm with respect to muscular strength as an index of fitness, despite muscular strength being independently associated with functional ability and mortality. PURPOSE: To examine the relationship between lower extremity muscular strength, @entity3 ( @entity3 ), and all-cause mortality among normal weight, overweight and @entity1 individuals. METHODS: Data from the 1999-2002 NHANES were used (N=2740 adults; >= 50years). @entity3 values were obtained from a blood sample. Lower body isokinetic knee extensor strength (IKES) was assessed using a Kin Kom MP isokinetic dynamometer. @entity0 data was linked to death certificate data from the National Death Index to ascertain all-cause mortality status. @entity0 were classified, based on body mass index (BMI) and strength as: normal weight and unfit (<75th IKES percentile); overweight and unfit; @entity1 and unfit: normal weight and fit (>= 75th IKES percentile); overweight and fit; and @entity1 and fit. RESULTS: Independent of physical activity and other confounders, compared to those who were normal weight and unfit, unfit overweight (b=.14, p=0.009), unfit @entity1 (b=.33, p<0.001), and @entity1 and fit (b=.17, p=0.008) @entity0 , had higher @entity3 levels. However, there was no difference in @entity3 levels between normal weight and unfit @entity0 and overweight and fit @entity0 (b=0.04, p=0.35). Compared to normal weight unfit adults, overweight fit (HR=0.28; 95% CI: 0.11-0.70; p=0.008) adults had a lower hazard rate for all-cause mortality. CONCLUSIONS: These finding suggest that increased lower body strength, independent of physical activity, may reduce premature all-cause mortality and attenuate systemic @entity2 among overweight adults.

title: Lower extremity strength, systemic XXXX and all-cause mortality: Application to the "fat but fit" paradigm using cross-sectional and longitudinal designs.

answer: @entity2


abstract: UNASSIGNED: @entity3 and opioid peptides play a central role in @entity2 transmission, modulation and inhibition. The treatment of @entity2 is very important in medicine and many studies using @entity4 antagonists failed to show significant analgesic effects in @entity0 . Recent investigations suggest that both pronociceptive tachykinins and the analgesic opioid systems are important for normal @entity2 sensation. The analysis of opioid peptides in @entity5 (-/-) spinal cord tissues offers a great opportunity to verify the influence of the tachykinin system on specific opioid peptides. The objectives of this study were to develop an HPLC-MS/MRM assay to quantify targeted peptides in spinal cord tissues. Secondly, we wanted to verify if the @entity5 (-/-) @entity1 endogenous opioid system is hampered and therefore affects significantly the @entity2 modulatory pathways. Targeted neuropeptides were analyzed by high performance liquid chromatography linear ion trap mass spectrometry. Our results reveal that EM-2, Leu-Enk and Dyn A were down-regulated in @entity5 (-/-) spinal cord tissues. Interestingly, Dyn A was almost 3 fold down-regulated (p<0.0001). No significant concentration differences were observed in @entity1 @entity5 (-/-) spinal cords for Met-Enk and @entity6 . The analysis of @entity5 (-/-) @entity1 spinal cords revealed noteworthy decreases of EM-2, Leu-Enk and Dyn A concentrations which strongly suggest a significant impact on the endogenous @entity2 -relieving mechanisms. These observations may have insightful impact on future analgesic drug developments and therapeutic strategies.

title: Liquid chromatography-electrospray linear ion trap mass spectrometry analysis of targeted neuropeptides in XXXX (-/-) @entity1 spinal cords reveals significant lower concentration of opioid peptides.

answer: @entity5


abstract: UNASSIGNED: @entity3 and opioid peptides play a central role in @entity2 transmission, modulation and inhibition. The treatment of @entity2 is very important in medicine and many studies using @entity4 antagonists failed to show significant analgesic effects in @entity0 . Recent investigations suggest that both pronociceptive tachykinins and the analgesic opioid systems are important for normal @entity2 sensation. The analysis of opioid peptides in @entity5 (-/-) spinal cord tissues offers a great opportunity to verify the influence of the tachykinin system on specific opioid peptides. The objectives of this study were to develop an HPLC-MS/MRM assay to quantify targeted peptides in spinal cord tissues. Secondly, we wanted to verify if the @entity5 (-/-) @entity1 endogenous opioid system is hampered and therefore affects significantly the @entity2 modulatory pathways. Targeted neuropeptides were analyzed by high performance liquid chromatography linear ion trap mass spectrometry. Our results reveal that EM-2, Leu-Enk and Dyn A were down-regulated in @entity5 (-/-) spinal cord tissues. Interestingly, Dyn A was almost 3 fold down-regulated (p<0.0001). No significant concentration differences were observed in @entity1 @entity5 (-/-) spinal cords for Met-Enk and @entity6 . The analysis of @entity5 (-/-) @entity1 spinal cords revealed noteworthy decreases of EM-2, Leu-Enk and Dyn A concentrations which strongly suggest a significant impact on the endogenous @entity2 -relieving mechanisms. These observations may have insightful impact on future analgesic drug developments and therapeutic strategies.

title: Liquid chromatography-electrospray linear ion trap mass spectrometry analysis of targeted neuropeptides in @entity5 (-/-) XXXX spinal cords reveals significant lower concentration of opioid peptides.

answer: @entity1


abstract: UNASSIGNED: There is a lack of studies using @entity3 strains isolated from @entity0 @entity0 . Here, we present a pathological study of three strains obtained from @entity0 cases of @entity4 in Brazil using inbred @entity1 after @entity2 with 10 tissue cysts. Multiplex-nested PCR-RFLP of eleven loci revealed atypical genotypes commonly found in Brazil: toxodb #8 for TgCTBr5 and TgCTBr16 strains and toxodb #11 for the TgCTBr9 strain. BALB/c and C57BL/6 @entity1 were evaluated for survival and histological changes during the acute phase of the disease. All @entity1 inoculated with the non-virulent TgCTBR5 strain survived after 30 days, although irreversible tissue damage was found. In contrast, no @entity1 were resistant to infection with the highly virulent TgCTBR9 strain. The TgCTBr16 strain resulted in 80% survival in @entity1 . However, this strain presented @entity2 , especially by the oral route of infection. Despite being identified with the same genotype, TgCTBr5 and TgCTBr16 strains showed biological differences. Histopathologic analysis revealed liver and lungs to be the most affected organs, and the pattern of tissue injury was similar to that found in @entity1 inoculated perorally with strains belonging to clonal genotypes. However, there was a variation in the intensity of ileum lesions according to @entity3 and @entity1 lineage. C57BL/6 @entity1 showed higher susceptibility than BALB/c for histological lesions. Taken together, these results revealed that the pathogenesis of @entity3 strains belonging to atypical genotypes can induce similar tissue damage to those from clonal genotypes, although intrinsic aspects of the strains seem critical to the induction of @entity5 in the infected host.

title: Pathological changes in acute experimental toxoplasmosis with XXXX strains obtained from @entity0 cases of congenital disease.

answer: @entity3


abstract: UNASSIGNED: There is a lack of studies using @entity3 strains isolated from @entity0 @entity0 . Here, we present a pathological study of three strains obtained from @entity0 cases of @entity4 in Brazil using inbred @entity1 after @entity2 with 10 tissue cysts. Multiplex-nested PCR-RFLP of eleven loci revealed atypical genotypes commonly found in Brazil: toxodb #8 for TgCTBr5 and TgCTBr16 strains and toxodb #11 for the TgCTBr9 strain. BALB/c and C57BL/6 @entity1 were evaluated for survival and histological changes during the acute phase of the disease. All @entity1 inoculated with the non-virulent TgCTBR5 strain survived after 30 days, although irreversible tissue damage was found. In contrast, no @entity1 were resistant to infection with the highly virulent TgCTBR9 strain. The TgCTBr16 strain resulted in 80% survival in @entity1 . However, this strain presented @entity2 , especially by the oral route of infection. Despite being identified with the same genotype, TgCTBr5 and TgCTBr16 strains showed biological differences. Histopathologic analysis revealed liver and lungs to be the most affected organs, and the pattern of tissue injury was similar to that found in @entity1 inoculated perorally with strains belonging to clonal genotypes. However, there was a variation in the intensity of ileum lesions according to @entity3 and @entity1 lineage. C57BL/6 @entity1 showed higher susceptibility than BALB/c for histological lesions. Taken together, these results revealed that the pathogenesis of @entity3 strains belonging to atypical genotypes can induce similar tissue damage to those from clonal genotypes, although intrinsic aspects of the strains seem critical to the induction of @entity5 in the infected host.

title: Pathological changes in acute experimental toxoplasmosis with @entity3 strains obtained from XXXX cases of congenital disease.

answer: @entity0


abstract: UNASSIGNED: Drug-containing nanoparticles, the foundation of nanomedicine, provide promise for the safe and effective delivery of drugs to their targets. In this study, we developed a simple method to determine the relative quantities of nanoparticle-encapsulated drugs by HPLC using a commercially available monolithic @entity2 column. @entity0 - and @entity1 -containing nanoparticles produced nearly simultaneous elution peaks (~7  min), suggesting that elution was largely driven by hydrodynamic effects and was relatively unaffected by differences in the encapsulated drug. A good correlation was observed between the intensity of the nanoparticle peak and the relative quantity of encapsulated drug. We used our method to characterize the effects of drug quantity and nanoparticle size on drug encapsulation rates within the nanoparticles. Encapsulation increased with increasing quantities of the drug in the preparation solution. This effect was greater for @entity1 than for @entity0 . Although absolute encapsulation also increased with increasing nanoparticle size, encapsulation efficiency decreased. Thus, the monolith column is suitable for evaluating nanomedicine quality and may be used to evaluate many kinds of nanomaterials. Graphical Abstract Evaluation method of quantity of drug encapsulated within nanoparticles was developed. The method can be applicable for a rapid quality assurance of nanomedicine.

title: Rapid evaluation of the quantity of drugs encapsulated within nanoparticles by high-performance liquid chromatography in a monolithic XXXX column.

answer: @entity2


abstract: UNASSIGNED: The clinical utility of routine electroencephalography (EEG) after a first unprovoked @entity2 remains uncertain. Its diagnostic accuracy in identifying adults and @entity0 with new onset @entity1 was examined. A systematic review and meta-analysis of studies examining individuals who underwent routine EEG after a first unprovoked @entity2 and were followed for @entity2 recurrence for at least 1  year was performed. A 'positive' test was defined by the presence of @entity1 ( @entity1 ). Pooled sensitivity and specificity estimates were calculated using a bivariate random effects regression model. In all, 3096 records were reviewed, from which 15 studies were extracted with a total of 1799 @entity0 . Amongst adult studies, the sensitivity and specificity (95% confidence interval) of routine EEG were 17.3% (7.9, 33.8) and 94.7% (73.7, 99.1), respectively. Amongst @entity0 studies, the pooled sensitivity and specificity were 57.8% (49.7, 65.6) and 69.6% (57.5, 79.5), respectively. Based upon our positive likelihood ratios, and assuming a pre-test probability of 50%, an adult with @entity1 on routine EEG after a first unprovoked @entity2 has a 77% probability of having a second @entity2 , whilst a @entity0 with similar findings has a 66% probability. Further studies are required to examine the impact of @entity0 characteristics and EEG features on the diagnostic accuracy of routine EEG for new onset @entity1 .

title: The diagnostic accuracy of routine electroencephalography after a first unprovoked XXXX .

answer: @entity2


abstract: As an advanced surgical procedure, laparoscopic Roux-en-Y gastric bypass (LRYGB) is associated with considerable morbidity, especially in the learning curve period. The aim of this study was to evaluate the role of endoscopy during LRYGB surgery in assessing the gastric pouch and @entity2 for air leak, @entity4 , and structure at the beginning of a bariatric surgery program. @entity0 who underwent LRYGB for morbid obesity between May 2008 and May 2009 were included in this study. After the completion of the @entity2 , an endoscopic examination was carried out. The transection line and @entity2 site were examined for @entity4 and patency and inspected for air leak under laparoscopic vision. Thirteen morbidly @entity1 @entity0 (mean body mass index, 48.0        6.8  kg/m(2)) were evaluated by endoscopic examination during the LRYGB operation. None of the cases had @entity4 at the transection line or @entity2 site. In two @entity0 , air leak test was positive and the @entity2 was reinforced with additional sutures. All the @entity0 , including those with positive air leak test, were discharged from the hospital with no leak complications. After a mean follow-up of 9.1        5.5  months, except for the @entity0 who underwent balloon dilatation, no other @entity0 had anastomotic stricture. Intraoperative endoscopy is invaluable in the assessment of @entity4 , anastomotic patency, and air leak during LRYGB, and it might be a helpful auxiliary tool to decrease morbidity during the learning curve period. Also, it helps solve intraoperative problems during the surgery so that @entity3 might be prevented.

title: Intraoperative endoscopic assessment of the pouch and XXXX during laparoscopic Roux-en-Y gastric bypass.

answer: @entity2


abstract: BACKGROUND AND OBJECTIVES: Though necessary for improved outcomes, surgical resection is often limited in @entity0 with locally advanced @entity6 (LAPCs). We evaluated the efficacy of the approach adopted by our institution of using modified FOLFIRINOX chemotherapy followed by radiation with concurrent @entity3 or @entity5 for @entity0 with LAPCs, in an effort to enhance resectability while improving the @entity4 profile compared with similar treatment regimens. METHODS: We included 29 consecutive @entity0 with LAPC treated at our institution with the above approach in this review. We evaluated rates of resection, locol control, and survival outcomes in this cohort. RESULTS: The median follow up for this series of @entity0 was 15.2 months. Approximately half the @entity0 were unresectable at presentation. After neoadjuvant therapy, 41.3% of all @entity0 were able to undergo resection of their @entity2 and 83% achieved an R0 resection. One-year local control for the entire cohort was 85%; one-year progression-free and overall were 49.2% and 65.5%, respectively. High rates of @entity1 were seen regardless of resectability. There were minimal @entity4 in this cohort. CONCLUSIONS: Neoadjuvant therapy with induction modified FOLFIRINOX and chemoradiation presents a well-tolerated, promising treatment approach for @entity0 with LAPC. High rates of @entity1 highlight the need to optimize systemic and targeted agents for @entity6 . J. Surg. Oncol. 2015 111:1028-1034.    2015 Wiley Periodicals, Inc.

title: Neoadjuvant modified FOLFIRINOX and chemoradiation therapy for locally advanced XXXX improves resectability.

answer: @entity6


abstract: INTRODUCTION: @entity4 can be a lethal disease, rarely suspected in the clinical scenario. It represents about 25% of all @entity3 cases in @entity0 older than 65. There is a classification of @entity4 based on the onset time: acute, subacute and chronic ( @entity2 ). We describe the first reported case of chronic @entity4 . CASE PRESENTATION: A 78-year-old female was admitted to the ER with a 15-day case of consistent @entity3 . The subject reported a five-year history of recurrent hospital admissions that resolved spontaneously after non-surgical management. @entity2 was diagnosed and managed with enterolithotomy. After five days of postoperative evolution the @entity0 was discharged, and at six months follow up, no other hospital admission or relapse has been registered. DISCUSSION: The @entity4 diagnosis demands a higher clinical suspicion, there is no biochemical marker, and an abdominal CT is ideal for imaging-based diagnosis. There is no consensus on the optimal surgical approach. CONCLUSION: We describe the first case of @entity2 and a gastro-jejune and gastric-choledochus double @entity1 . We emphasize the importance of higher clinical suspicion for @entity0 with @entity3 older than 65 years old and make evident that although there are not evidence-based guidelines for this treatment, enterolithotomy is a recommended approach.

title: XXXX : A case report and review of the literature.

answer: @entity2


abstract: OBJECTIVE: To examine the association between changes in knee muscle strength (extensor and flexor muscles separately, and mean values) and changes in activity limitations in @entity0 with established @entity2 at 2 years. METHODS: Data from 186 @entity0 with @entity2 , part of the Amsterdam @entity1 cohort, were gathered at baseline and at 2-year follow-up. Strength of the knee extensor and flexor muscles were assessed using an isokinetic dynamometer. Activity limitations were assessed using the Western Ontario and @entity1 Index (WOMAC) - Physical Function subscale, the Get Up and Go test (GUG), and the 12-steps stairs test. Univariate and multivariate linear regression analyses were used to assess the association between changes in muscle strength and changes in activity limitations, adjusting for relevant confounders and baseline activity limitations. RESULTS: There was an overall 16% increase in mean knee muscle strength (p   <   0.001), 19% increase in knee extensor muscle strength (p   <   0.001), and 17% increase in knee flexor muscle strength (p   <   0.001) at 2 years. Increased mean knee muscle strength and knee flexor muscle strength were associated with better self-reported physical function (WOMAC) (b   =   -5.7, p   =   0.03 and b   =   -6.2, p   =   0.05), decreased time on the GUG (b   =   -1.2, p   =   0.003 and b   =   -1.4, p   =   0.05) and decreased time on the stairs test (b   =   -4.4, p   <   0.001 and b   =   -6.6, p   <   0.001). Increased extensor muscle strength was associated only with decreased time on the stairs test (b   =   -2.7, p   <   0.001). CONCLUSION: Increased knee muscle strength, mainly in the knee flexors, was associated with decreased activity limitations in @entity0 with @entity2 at 2 years. Thus, differences in muscle strength may partially explain the between- @entity0 variability in activity limitations.

title: Increased knee muscle strength is associated with decreased activity limitations in established XXXX : Two-year follow-up study in the Amsterdam @entity1 cohort.

answer: @entity2


abstract: OBJECTIVE: To examine the association between changes in knee muscle strength (extensor and flexor muscles separately, and mean values) and changes in activity limitations in @entity0 with established @entity2 at 2 years. METHODS: Data from 186 @entity0 with @entity2 , part of the Amsterdam @entity1 cohort, were gathered at baseline and at 2-year follow-up. Strength of the knee extensor and flexor muscles were assessed using an isokinetic dynamometer. Activity limitations were assessed using the Western Ontario and @entity1 Index (WOMAC) - Physical Function subscale, the Get Up and Go test (GUG), and the 12-steps stairs test. Univariate and multivariate linear regression analyses were used to assess the association between changes in muscle strength and changes in activity limitations, adjusting for relevant confounders and baseline activity limitations. RESULTS: There was an overall 16% increase in mean knee muscle strength (p   <   0.001), 19% increase in knee extensor muscle strength (p   <   0.001), and 17% increase in knee flexor muscle strength (p   <   0.001) at 2 years. Increased mean knee muscle strength and knee flexor muscle strength were associated with better self-reported physical function (WOMAC) (b   =   -5.7, p   =   0.03 and b   =   -6.2, p   =   0.05), decreased time on the GUG (b   =   -1.2, p   =   0.003 and b   =   -1.4, p   =   0.05) and decreased time on the stairs test (b   =   -4.4, p   <   0.001 and b   =   -6.6, p   <   0.001). Increased extensor muscle strength was associated only with decreased time on the stairs test (b   =   -2.7, p   <   0.001). CONCLUSION: Increased knee muscle strength, mainly in the knee flexors, was associated with decreased activity limitations in @entity0 with @entity2 at 2 years. Thus, differences in muscle strength may partially explain the between- @entity0 variability in activity limitations.

title: Increased knee muscle strength is associated with decreased activity limitations in established @entity2 : Two-year follow-up study in the Amsterdam XXXX cohort.

answer: @entity1


abstract: UNASSIGNED: Oral nonsteroidal antiinflammatory drugs (NSAIDs) are prescribed for @entity1 prophylaxis following at-risk injuries and procedures. We hypothesized that NSAIDs may be delivered locally in a wound for @entity1 prophylaxis. In in vitro work, we cultured osteoblasts with three commercially available NSAIDs and then measured cell viability and DNA content. @entity2 caused a 50% decrease in DNA at the lowest dose (0.0001 mM) and the most potent decrease in cell viability (<10% of control at 0.0005 mM). Ketorolac and @entity3 required 10 times the dose to achieve a comparable decrease (<20% of control at 0.005 mM). In an animal study, 20 @entity0 per treatment group received a full-thickness wound dressed with either saline-moistened gauze, saline-moistened chitosan sponge, or chitosan sponge loaded with @entity2 . After 28 days, we examined the tissue for healing. Wounds exposed to @entity2 loaded sponges demonstrated fewer inflammatory cells. All 20 @entity0 in the @entity2 group had complete epithelial coverage at 28 days. Eighteen (90%) wounds in the saline-chitosan group and 11 (55%) wounds in the saline-gauze group were healed. Locally delivered NSAIDs may be useful for @entity1 prophylaxis due to effects on osteoblast viability and lack of negative effects on wound healing. Clin Trans Sci 2015; Volume #: 1-3.

title: Locally Delivered Nonsteroidal Antiinflammatory Drug: A Potential Option for XXXX Prevention.

answer: @entity1


abstract: A 54-year-old @entity0 had emergency laparoscopic chelecystectomy for acute @entity10 . General inflammatory change (CRP 26.6 mg x dl(-1), WBC 26,800) was noted preoperatively. Anesthesia was induced with @entity6 and @entity7 and maintained with @entity9 in @entity1 and @entity7 . Operation was performed uneventfully within 128 min. At the end of the surgery, 0.1 mg of @entity13 was administrated. After confirming adequate respiration and oxygenation, endotracheal tube was removed. At that period, @entity2 ( @entity14 220 mmHg) and @entity3 (HR 122 beats x min(-1)) developed. Soon thereafter, he became @entity8 and complained of @entity5 with desaturation (Spo2 < 70%). After reintubation, massive pinkish babbly secretion flowed out from the endotracheal tube. Chest X-ray revealed diffuse bilateral infiltration of the lungs without @entity4 . He was transferred to the intensive care unit for mechanical ventilation. His condition improved progressively and was extubated on the POD 6. The cause of @entity12 is thought to be profound centralization of circulating volume associated with @entity11 -induced vasoconstriction due to rapid disappearance of @entity7 effect. Adequate analgesia is necessary during @entity7 -based anesthesia especially in @entity0 suffering from general inflammatory changes.

title: [Case of @entity12 due to excessive XXXX following extubation].

answer: @entity2


abstract: A 54-year-old @entity0 had emergency laparoscopic chelecystectomy for acute @entity10 . General inflammatory change (CRP 26.6 mg x dl(-1), WBC 26,800) was noted preoperatively. Anesthesia was induced with @entity6 and @entity7 and maintained with @entity9 in @entity1 and @entity7 . Operation was performed uneventfully within 128 min. At the end of the surgery, 0.1 mg of @entity13 was administrated. After confirming adequate respiration and oxygenation, endotracheal tube was removed. At that period, @entity2 ( @entity14 220 mmHg) and @entity3 (HR 122 beats x min(-1)) developed. Soon thereafter, he became @entity8 and complained of @entity5 with desaturation (Spo2 < 70%). After reintubation, massive pinkish babbly secretion flowed out from the endotracheal tube. Chest X-ray revealed diffuse bilateral infiltration of the lungs without @entity4 . He was transferred to the intensive care unit for mechanical ventilation. His condition improved progressively and was extubated on the POD 6. The cause of @entity12 is thought to be profound centralization of circulating volume associated with @entity11 -induced vasoconstriction due to rapid disappearance of @entity7 effect. Adequate analgesia is necessary during @entity7 -based anesthesia especially in @entity0 suffering from general inflammatory changes.

title: [Case of XXXX due to excessive @entity2 following extubation].

answer: @entity12


abstract: The effect of @entity2 (5 mg iv) on the leukocytosis of exercise was studied in seven normal young males. Leukocyte counts, plasma @entity0 (NE), @entity3 (E), and cardiac output were measured at rest and in the steady state of several submaximal work loads when subjects exercised on a cycle ergometer. The results in control experiments were compared with those obtained on a different day with @entity2 . @entity2 @entity1 at all work loads (P less than 0.001) but had no effect on the increase in cardiac output at increasing work loads. Plasma NE and E levels were similar at rest and in exercise in control and @entity2 studies. There was no effect of @entity2 on the increase in leukocyte counts with increasing work loads. Although @entity2 did not affect the increase in total leukocyte count, the increase in lymphocyte count at higher work loads was less with @entity2 . We conclude that the demargination of leukocytes from the pulmonary circulation in exercise is probably a mechanical effect of the increase in cardiac output. However, we have not excluded a contribution from a humoral event that would decrease the adherence of leukocytes to endothelium during exercise. The smaller increase in lymphocytes at higher work loads in the presence of @entity2 suggests that @entity4 affect the lymphocyte count over and above their effect on cardiac output.

title: Leukocytosis of exercise: role of cardiac output and XXXX .

answer: @entity4


abstract: UNASSIGNED: Using the prototype willingness model (PWM) as a framework, this study sought to explore the relationship between prototype perceptions, willingness and @entity1 consumption in a sample of adolescents in the United Kingdom (UK). Adolescents aged 11-17 were asked about their @entity1 prototype perceptions, willingness to drink, intentions, @entity1 consumption, @entity2 and harms using a cross-sectional online survey. @entity0 were recruited through opportunity sampling via schools and parents. The survey was completed by 178 respondents (51% female; 91 aged 11-15, 87 aged 16-17). Multivariate analysis revealed significant differences between @entity0 aged 11-15 and 16-17 on PWM measures, even when experience with drinking was accounted for (p  <  .001). There were significant interactions (p  <  .001) between age and prototype perceptions; younger @entity0 rated non-drinker prototypes as more favourable and more similar to the self than 16- and 17-year-old @entity0 . Willingness and intentions interacted with age; both measures were similar in 16- and 17-year-olds, whereas younger @entity0 scored significantly higher on willingness than intentions (p  <  .001). Three distinct scales of prototype descriptions were identified in principal components analysis. Characteristics related to sociability significantly predicted willingness to drink @entity1 in the sample (p  <  .001). This study extends previous research by demonstrating that the PWM can provide a theoretical explanation of adolescent drinking in the UK. The results suggest that 11- to 15-year-olds may be the most suitable age for an intervention that targets @entity1 prototypes, with a focus on sociability characteristics.

title: Age differences in XXXX prototype perceptions and willingness to drink in UK adolescents.

answer: @entity1


abstract: The 13-valent pneumococcal vaccine (PCV13) replaced the 7-valent vaccine (PCV7) on the Australian National Immunization Program (NIP) in 2011. Post-marketing surveillance of @entity1 ( @entity1 ) is crucial for detecting potential safety signals and maintaining confidence in the NIP. This study describes all @entity1 reported to Surveillance of Adverse Events following Vaccination in the Community (SAEFVIC), Melbourne, Australia, following both the primary series of PCV13 ( @entity0 <7 months) and the catch-up dose (12 months-35 months) in its first year of inclusion on the NIP. @entity1 reporting rates per 100,000 doses of vaccine administered were compared for the PCV13 primary series and PCV7 primary series in the previous year. SAEFVIC received 229 reports describing 406 @entity1 following @entity2 in the 12 months post introduction. There was no difference in the total number of @entity1 cases reported between the vaccines but 7 @entity1 categories were reported at a significantly higher rate following PCV13 compared with PCV7. No difference in reporting rate was observed for serious @entity1 (p = 0.25). Post-hoc analysis of a further 12 months of PCV13 data revealed that all 7 @entity1 categories that were initially reported at a significantly higher rate following PCV13 compared to PCV7 in the first 12 months post introduction, were no longer significantly increased in the 13-24 month period. The initial high reporting rate for several common @entity1 post PCV13 compared to PCV7 may be explained by heightened awareness of the new vaccine. There were no safety signals detected for rare or serious @entity1 that would require further investigation at this time.

title: Surveillance of adverse events following the introduction of 13-valent pneumococcal conjugate vaccine in XXXX , and comparison with adverse events following 7-valent pneumococcal conjugate vaccine, in Victoria, Australia.

answer: @entity0


abstract: Twenty-four cases of an unusual type of @entity2 with functioning stroma in which bands of @entity5 -hormone-producing cells were located adjacent to the @entity1 are presented. The cells were of stromal lutein cell type in 14 cases, stromal Leydig cell type in two cases, and hilus cell type in eight cases. Of the @entity1 with peripheral lutein cells, 11 were monodermal @entity3 , including eight examples of @entity10 , two strumal carcinoids, and one trabecular @entity7 ; the other three @entity1 in this group were a @entity4 , a @entity8 containing syncytiotrophoblast cells, and a metastatic @entity7 . The @entity1 with peripheral stromal Leydig cells were a @entity10 and a @entity7 . Three of the @entity1 with peripheral hilus cells were @entity9 , four were cysts of probable rete origin, and the eight was a @entity4 . The @entity0 ' ages ranged from 13-82 (average 58) years. Eighty percent of the @entity0 were postmenopausal; one was pregnant. Forty-two percent of the @entity0 had androgenic manifestations, 29% had evidence of hyperestrinism, and one (4%) had evidence of @entity6 excess. In 29% of the cases there was no clinical evidence of hormonal imbalance. Those @entity1 with peripheral stromal Leydig cells or hilus cells were accompanied by androgenic manifestations in over one-half the cases, and those @entity1 with peripheral lutein cells had a slightly higher association with estrogenic rather than androgenic changes. @entity0 chorionic gonadotropin and its beta subunit were demonstrated by the immunoperoxidase technique in some neoplastic cells in 4 of the 17 cases in which it was performed. @entity2 with peripheral steroid-hormone-producing cells should be distinguished from the typical @entity2 with functioning stroma, which contains lutein cells scattered throughout its stroma.

title: Functioning XXXX with peripheral steroid cell proliferation: a report of twenty-four cases.

answer: @entity2


abstract: The records of 101 @entity4 and/or heroin drug abusing @entity0 admitted consecutively to Fair Oaks Hospital were evaluated for history of IV @entity2 , antigen and serum antibody evidence of @entity3 , and elevation of serum SGPT. One @entity0 , an IV user, had @entity3 antigen present in his blood. No @entity0 had @entity1 (IgM) antibody present. Forty-five out of fifty-three (84.9%) IV abusers were Hep B Ab positive, while two out of twenty-nine non-IV abusers (6.9%) were positive. Twenty of fifty-three (43.4%) IV users had positive @entity1 Ab while one of twenty-nine (3.4%) of non-IV users were positive. Thirty-five of fifty-five (63.6%) IV users had elevated SGPT compared to five of forty-one (12.2%) in non-IV users. IV users tended to be older than non-IV users. The data presented in this article indicate that there is a greatly increased incidence of both @entity1 and B in IV drug users compared to non-IV users and that the @entity3 incidence is increased in a far greater amount than could be expected in a normal population. The type of drug injected ( @entity5 , other opiates, or @entity4 ) was not an important determinant. The presence of @entity3 antibodies in any drug abusing @entity0 who denies IV use is a strong indication that they may not be telling the truth about their past @entity2 . It makes little difference whether drug abusing @entity0 live in the inner city or the suburbs.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX in 101 consecutive suburban @entity4 and opiate users.

answer: @entity1


abstract: The records of 101 @entity4 and/or heroin drug abusing @entity0 admitted consecutively to Fair Oaks Hospital were evaluated for history of IV @entity2 , antigen and serum antibody evidence of @entity3 , and elevation of serum SGPT. One @entity0 , an IV user, had @entity3 antigen present in his blood. No @entity0 had @entity1 (IgM) antibody present. Forty-five out of fifty-three (84.9%) IV abusers were Hep B Ab positive, while two out of twenty-nine non-IV abusers (6.9%) were positive. Twenty of fifty-three (43.4%) IV users had positive @entity1 Ab while one of twenty-nine (3.4%) of non-IV users were positive. Thirty-five of fifty-five (63.6%) IV users had elevated SGPT compared to five of forty-one (12.2%) in non-IV users. IV users tended to be older than non-IV users. The data presented in this article indicate that there is a greatly increased incidence of both @entity1 and B in IV drug users compared to non-IV users and that the @entity3 incidence is increased in a far greater amount than could be expected in a normal population. The type of drug injected ( @entity5 , other opiates, or @entity4 ) was not an important determinant. The presence of @entity3 antibodies in any drug abusing @entity0 who denies IV use is a strong indication that they may not be telling the truth about their past @entity2 . It makes little difference whether drug abusing @entity0 live in the inner city or the suburbs.(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity1 in 101 consecutive suburban XXXX and opiate users.

answer: @entity4


abstract: Studies have been carried out in the presence of @entity1 , by utilizing a technique of platelet rapid filtration. Kinetic data suggest that @entity0 uptake across plasma membrane is the rate limiting step in its utilization. @entity1 is transported by facilitated diffusion. @entity0 is transferred at only 1/1200 of the rate of @entity0 . Transport system shows high affinity for substrate. Transport is inhibited by @entity2 , @entity10 and @entity7 . @entity11 does not affect @entity1 uptake. @entity9 can have activating or inhibitory effect. @entity3 is always activating. Insulin has no effect on rate transport. @entity0 , @entity8 , non radioactive @entity1 and @entity5 are strong competitors, whereas @entity4 and @entity6 compete weakly with @entity1 transport.

title: XXXX transport across plasma membrane in human platelets.

answer: @entity0


abstract: UNASSIGNED: @entity1 @entity6 ( @entity7 pyrophosphatase 1), also known as @entity6 , belongs to MazG-like @entity4 pyrophosphatase (NTP-PPase) superfamily. Being a newly identified pyrophosphatase, its relevance to tumorigenesis and the mechanisms are not well investigated. In the present study, we have confirmed our previous study that @entity6 was significantly hyperexpressed in @entity0 and further demonstrated its strong association with @entity2 progression and poor prognosis in @entity0 . Knockdown of @entity6 in @entity0 cell line MCF-7 cells remarkably retarded proliferation and colony formation in vitro. The capacity of mammosphere formation of MCF-7 was suppressed with the silence of @entity6 , which was consistent with the enhanced mammosphere-forming ability in @entity6 -overexpressed MDA-MB-231 cells. To further dissect the mechanisms of @entity6 in promoting @entity2 cell growth and @entity3 maintenance, its biochemical properties and biological functions were investigated. @entity6 displayed bioactive form with tetrameric structure similar to other MazG domain-containing pyrophosphatases based on structure simulation. A substrate preference for @entity7 and its methylated or @entity5 -modified derivatives over the other canonical (deoxy-) NTPs was demonstrated from enzymatic assay. This substrate preference was also proved in @entity0 cells that the intracellular @entity8 level increased in @entity6 -deficient MCF-7 cells but decreased in @entity6 -overexpressed MDA-MB-231 cells. Moreover, global methylation level was elevated in @entity6 -knockdown MCF-7 cells or mammosphere-forming MCF-7 cells but decreased significantly in @entity6 -overexpressed MDA-MB-231 cells and its mammospheres. Our results thus indicated that @entity1 @entity6 was capable of modulating the concentration of intracellular @entity8 . This in turn affected global methylation, contributing to a known phenomenon of hypomethylation related to the @entity2 cell growth and @entity3 maintenance. Our current investigations point to the pathological functions of @entity6 overexpression in @entity0 cells with aberrant @entity7 metabolism and epigenetic modification.

title: @entity1 @entity7 pyrophosphatase 1 promotes XXXX cell growth and @entity3 through the modulation on @entity8 metabolism and global hypomethylation.

answer: @entity0


abstract: UNASSIGNED: @entity1 @entity6 ( @entity7 pyrophosphatase 1), also known as @entity6 , belongs to MazG-like @entity4 pyrophosphatase (NTP-PPase) superfamily. Being a newly identified pyrophosphatase, its relevance to tumorigenesis and the mechanisms are not well investigated. In the present study, we have confirmed our previous study that @entity6 was significantly hyperexpressed in @entity0 and further demonstrated its strong association with @entity2 progression and poor prognosis in @entity0 . Knockdown of @entity6 in @entity0 cell line MCF-7 cells remarkably retarded proliferation and colony formation in vitro. The capacity of mammosphere formation of MCF-7 was suppressed with the silence of @entity6 , which was consistent with the enhanced mammosphere-forming ability in @entity6 -overexpressed MDA-MB-231 cells. To further dissect the mechanisms of @entity6 in promoting @entity2 cell growth and @entity3 maintenance, its biochemical properties and biological functions were investigated. @entity6 displayed bioactive form with tetrameric structure similar to other MazG domain-containing pyrophosphatases based on structure simulation. A substrate preference for @entity7 and its methylated or @entity5 -modified derivatives over the other canonical (deoxy-) NTPs was demonstrated from enzymatic assay. This substrate preference was also proved in @entity0 cells that the intracellular @entity8 level increased in @entity6 -deficient MCF-7 cells but decreased in @entity6 -overexpressed MDA-MB-231 cells. Moreover, global methylation level was elevated in @entity6 -knockdown MCF-7 cells or mammosphere-forming MCF-7 cells but decreased significantly in @entity6 -overexpressed MDA-MB-231 cells and its mammospheres. Our results thus indicated that @entity1 @entity6 was capable of modulating the concentration of intracellular @entity8 . This in turn affected global methylation, contributing to a known phenomenon of hypomethylation related to the @entity2 cell growth and @entity3 maintenance. Our current investigations point to the pathological functions of @entity6 overexpression in @entity0 cells with aberrant @entity7 metabolism and epigenetic modification.

title: @entity1 @entity7 pyrophosphatase 1 promotes @entity0 cell growth and XXXX through the modulation on @entity8 metabolism and global hypomethylation.

answer: @entity3


abstract: UNASSIGNED: @entity1 @entity6 ( @entity7 pyrophosphatase 1), also known as @entity6 , belongs to MazG-like @entity4 pyrophosphatase (NTP-PPase) superfamily. Being a newly identified pyrophosphatase, its relevance to tumorigenesis and the mechanisms are not well investigated. In the present study, we have confirmed our previous study that @entity6 was significantly hyperexpressed in @entity0 and further demonstrated its strong association with @entity2 progression and poor prognosis in @entity0 . Knockdown of @entity6 in @entity0 cell line MCF-7 cells remarkably retarded proliferation and colony formation in vitro. The capacity of mammosphere formation of MCF-7 was suppressed with the silence of @entity6 , which was consistent with the enhanced mammosphere-forming ability in @entity6 -overexpressed MDA-MB-231 cells. To further dissect the mechanisms of @entity6 in promoting @entity2 cell growth and @entity3 maintenance, its biochemical properties and biological functions were investigated. @entity6 displayed bioactive form with tetrameric structure similar to other MazG domain-containing pyrophosphatases based on structure simulation. A substrate preference for @entity7 and its methylated or @entity5 -modified derivatives over the other canonical (deoxy-) NTPs was demonstrated from enzymatic assay. This substrate preference was also proved in @entity0 cells that the intracellular @entity8 level increased in @entity6 -deficient MCF-7 cells but decreased in @entity6 -overexpressed MDA-MB-231 cells. Moreover, global methylation level was elevated in @entity6 -knockdown MCF-7 cells or mammosphere-forming MCF-7 cells but decreased significantly in @entity6 -overexpressed MDA-MB-231 cells and its mammospheres. Our results thus indicated that @entity1 @entity6 was capable of modulating the concentration of intracellular @entity8 . This in turn affected global methylation, contributing to a known phenomenon of hypomethylation related to the @entity2 cell growth and @entity3 maintenance. Our current investigations point to the pathological functions of @entity6 overexpression in @entity0 cells with aberrant @entity7 metabolism and epigenetic modification.

title: @entity1 XXXX pyrophosphatase 1 promotes @entity0 cell growth and @entity3 through the modulation on @entity8 metabolism and global hypomethylation.

answer: @entity7


abstract: UNASSIGNED: @entity1 @entity6 ( @entity7 pyrophosphatase 1), also known as @entity6 , belongs to MazG-like @entity4 pyrophosphatase (NTP-PPase) superfamily. Being a newly identified pyrophosphatase, its relevance to tumorigenesis and the mechanisms are not well investigated. In the present study, we have confirmed our previous study that @entity6 was significantly hyperexpressed in @entity0 and further demonstrated its strong association with @entity2 progression and poor prognosis in @entity0 . Knockdown of @entity6 in @entity0 cell line MCF-7 cells remarkably retarded proliferation and colony formation in vitro. The capacity of mammosphere formation of MCF-7 was suppressed with the silence of @entity6 , which was consistent with the enhanced mammosphere-forming ability in @entity6 -overexpressed MDA-MB-231 cells. To further dissect the mechanisms of @entity6 in promoting @entity2 cell growth and @entity3 maintenance, its biochemical properties and biological functions were investigated. @entity6 displayed bioactive form with tetrameric structure similar to other MazG domain-containing pyrophosphatases based on structure simulation. A substrate preference for @entity7 and its methylated or @entity5 -modified derivatives over the other canonical (deoxy-) NTPs was demonstrated from enzymatic assay. This substrate preference was also proved in @entity0 cells that the intracellular @entity8 level increased in @entity6 -deficient MCF-7 cells but decreased in @entity6 -overexpressed MDA-MB-231 cells. Moreover, global methylation level was elevated in @entity6 -knockdown MCF-7 cells or mammosphere-forming MCF-7 cells but decreased significantly in @entity6 -overexpressed MDA-MB-231 cells and its mammospheres. Our results thus indicated that @entity1 @entity6 was capable of modulating the concentration of intracellular @entity8 . This in turn affected global methylation, contributing to a known phenomenon of hypomethylation related to the @entity2 cell growth and @entity3 maintenance. Our current investigations point to the pathological functions of @entity6 overexpression in @entity0 cells with aberrant @entity7 metabolism and epigenetic modification.

title: @entity1 @entity7 pyrophosphatase 1 promotes @entity0 cell growth and @entity3 through the modulation on XXXX metabolism and global hypomethylation.

answer: @entity8


abstract: UNASSIGNED: @entity1 @entity6 ( @entity7 pyrophosphatase 1), also known as @entity6 , belongs to MazG-like @entity4 pyrophosphatase (NTP-PPase) superfamily. Being a newly identified pyrophosphatase, its relevance to tumorigenesis and the mechanisms are not well investigated. In the present study, we have confirmed our previous study that @entity6 was significantly hyperexpressed in @entity0 and further demonstrated its strong association with @entity2 progression and poor prognosis in @entity0 . Knockdown of @entity6 in @entity0 cell line MCF-7 cells remarkably retarded proliferation and colony formation in vitro. The capacity of mammosphere formation of MCF-7 was suppressed with the silence of @entity6 , which was consistent with the enhanced mammosphere-forming ability in @entity6 -overexpressed MDA-MB-231 cells. To further dissect the mechanisms of @entity6 in promoting @entity2 cell growth and @entity3 maintenance, its biochemical properties and biological functions were investigated. @entity6 displayed bioactive form with tetrameric structure similar to other MazG domain-containing pyrophosphatases based on structure simulation. A substrate preference for @entity7 and its methylated or @entity5 -modified derivatives over the other canonical (deoxy-) NTPs was demonstrated from enzymatic assay. This substrate preference was also proved in @entity0 cells that the intracellular @entity8 level increased in @entity6 -deficient MCF-7 cells but decreased in @entity6 -overexpressed MDA-MB-231 cells. Moreover, global methylation level was elevated in @entity6 -knockdown MCF-7 cells or mammosphere-forming MCF-7 cells but decreased significantly in @entity6 -overexpressed MDA-MB-231 cells and its mammospheres. Our results thus indicated that @entity1 @entity6 was capable of modulating the concentration of intracellular @entity8 . This in turn affected global methylation, contributing to a known phenomenon of hypomethylation related to the @entity2 cell growth and @entity3 maintenance. Our current investigations point to the pathological functions of @entity6 overexpression in @entity0 cells with aberrant @entity7 metabolism and epigenetic modification.

title: XXXX @entity7 pyrophosphatase 1 promotes @entity0 cell growth and @entity3 through the modulation on @entity8 metabolism and global hypomethylation.

answer: @entity1