abstract: @entity1 ( @entity1 ) and @entity2 ( @entity2 ) are rare antibody mediated @entity3 (NMJ) respectively. Both diseases are predominantly mediated by IgG1 antibodies that activate complement. There have been increasing reports of @entity0 who develop both disorders. Given the rarity of both diseases it would seem that these occurrences are not purely coincidental. There is heterogeneity between the cases described in the literature but common trends are observed in @entity0 who develop both disorders. Most @entity0 described are female. Typically the @entity2 precedes the @entity1 and the majority of @entity0 have undergone thymectomy. Generally, the symptoms of @entity2 are mild but the @entity1 tends to follow a more aggressive clinical course. The pathogenesis of @entity1 in combination with @entity2 is unknown, but thymectomy has been implicated in a subset of @entity0 . We present the case of a female @entity0 who developed @entity1 on a background of sero-positive @entity2 and discuss the relevant literature.

title: @entity2 and XXXX opica: A causal link.

answer: @entity1


abstract: BACKGROUND: Adenotonsillectomy (T_A) may not completely eliminate @entity1 ( @entity1 ), and residual @entity1 can result in progressive @entity1 . Persistence of mouth breathing post-T_As plays a role in progressive worsening through an increase of upper airway resistance during sleep with secondary impact on orofacial growth. METHODS: Retrospective study on non-overweight and non-syndromic prepubertal @entity0 with @entity1 treated by T_A with pre- and post-surgery clinical and polysomnographic (PSG) evaluations including systematic monitoring of mouth breathing (initial cohort). All @entity0 with mouth breathing were then referred for myofunctional treatment (MFT), with clinical follow-up 6  months later and @entity2  year post-surgery. Only a limited subgroup followed the recommendations to undergo MFT with subsequent PSG (follow-up subgroup). RESULTS: Sixty-four prepubertal @entity0 meeting inclusion criteria for the initial cohort were investigated. There was significant symptomatic improvement in all @entity0 post-T_A, but 26 @entity0 had residual @entity1 with an AHI   >   1.5 events/hour and 35 @entity0 (including the previous 26) had evidence of "mouth breathing" during sleep as defined [minimum of 44  % and a maximum of 100  % of total sleep time, mean 69        11  % "mouth breather" subgroup and mean 4        3.9  %, range 0 and 10.3  % "non-mouth breathers"]. Eighteen @entity0 (follow-up cohort), all in the "mouth breathing" group, were investigated at 1  year follow-up with only nine having undergone 6  months of MFT. The non- MFT subjects were significantly worse than the MFT-treated cohort. MFT led to normalization of clinical and PSG findings. CONCLUSION: Assessment of mouth breathing during sleep should be systematically performed post-T_A and the persistence of mouth breathing should be treated with MFT.

title: Mouth breathing, "nasal disuse," and pediatric XXXX .

answer: @entity1


abstract: BACKGROUND: Criteria for identifying @entity2 ( @entity2 ) @entity0 with @entity1 , which would be useful for clinical decision making, are currently unavailable. OBJECTIVE: Identify @entity2 @entity0 with @entity1 characterized by rapid disability progression. METHODS: Data from a 2-year, phase 3, double-blind, placebo-controlled trial with long-term follow-up evaluations of @entity2 @entity0 taking either intramuscular interferon beta-1a (IM IFNb-1a, 30 g) or placebo with baseline Expanded Disability Status Scale (EDSS) scores of 1.0-3.5 were retrospectively analyzed. @entity0 with a >= 2.0-point increase in EDSS score, resulting in a score >= 4.0 by study end, were considered to have @entity1 @entity2 . The risk of a poor long-term outcome, defined as an EDSS score >= 8.0 at 8 years of follow-up, was calculated as an odds ratio from a logistic regression model comparing @entity0 with and without @entity1 @entity2 . RESULTS: Only 25 @entity0 met the criteria for @entity1 @entity2 . Among these @entity0 , mean disease duration was 5.1  3.85 years, mean baseline age was 37.2  6.35 years, and mean baseline EDSS score was 2.8  0.74. Fewer IM IFNb-1a-treated than placebo-treated @entity0 met the criteria for @entity1 @entity2 at 2 years (7% vs 22% on placebo, p=0.0072). Thirteen @entity0 reached the EDSS milestone of >= 8.0 by the end of the 8-year follow-up. The odds ratio for attaining severe disability was 86.4 (95% CI, 10.3-726.4; p<0.0001) for @entity0 with @entity1 @entity2 compared to @entity0 without @entity1 @entity2 . CONCLUSIONS: Defining @entity1 @entity2 based on rapid EDSS progression was useful in identifying @entity0 at risk for more severe disease course.

title: Aggressive XXXX characterized by rapid disability progression.

answer: @entity2


abstract: BACKGROUND: In Africa, @entity2 and @entity1 are currently used in combination for annual mass drug administration (MDA) for @entity3 ( @entity3 ) elimination. Rapid and sustained clearance is desirable for public health impact and elimination of @entity3 . Increasing the dose and/or frequency of @entity2 and @entity1 treatment may be more effective in clearing microfilariae than standard MDA. METHODS: We conducted a randomised controlled open label trial in northern Malawi comparing three modified treatment groups to standard dosage of @entity1 and @entity2 in adults with confirmed circulating @entity3 antigen and microfilaria. @entity0 were followed-up every 6 months for 2 years for repeat microfilarial counts and safety assessments. RESULTS: A total of 1851 adults were screened and 70 with microfilarial counts >80 microfilariae/ml were randomised. All treatment groups achieved a significant reduction of microfilariae levels by 12- and 24-months of follow-up. Doubling the standard dose and administering it twice yearly showed a non-significant tendency towards faster and more complete clearance. There were no serious adverse reactions. CONCLUSIONS: In this small study, all regimens effectively cleared microfilaria. Standard treatment may be adequate in settings like Malawi but not in all endemic settings and larger studies are required to demonstrate benefit of higher dosages. [ClinicalTrials.gov identifier: NCT01213576].

title: Randomised controlled clinical trial of increased dose and frequency of XXXX and @entity1 on Wuchereria bancrofti microfilarial clearance in northern Malawi.

answer: @entity2


abstract: BACKGROUND: In Africa, @entity2 and @entity1 are currently used in combination for annual mass drug administration (MDA) for @entity3 ( @entity3 ) elimination. Rapid and sustained clearance is desirable for public health impact and elimination of @entity3 . Increasing the dose and/or frequency of @entity2 and @entity1 treatment may be more effective in clearing microfilariae than standard MDA. METHODS: We conducted a randomised controlled open label trial in northern Malawi comparing three modified treatment groups to standard dosage of @entity1 and @entity2 in adults with confirmed circulating @entity3 antigen and microfilaria. @entity0 were followed-up every 6 months for 2 years for repeat microfilarial counts and safety assessments. RESULTS: A total of 1851 adults were screened and 70 with microfilarial counts >80 microfilariae/ml were randomised. All treatment groups achieved a significant reduction of microfilariae levels by 12- and 24-months of follow-up. Doubling the standard dose and administering it twice yearly showed a non-significant tendency towards faster and more complete clearance. There were no serious adverse reactions. CONCLUSIONS: In this small study, all regimens effectively cleared microfilaria. Standard treatment may be adequate in settings like Malawi but not in all endemic settings and larger studies are required to demonstrate benefit of higher dosages. [ClinicalTrials.gov identifier: NCT01213576].

title: Randomised controlled clinical trial of increased dose and frequency of @entity2 and XXXX on Wuchereria bancrofti microfilarial clearance in northern Malawi.

answer: @entity1


abstract: OBJECTIVE: To determine the nature, scope and effectiveness of interventions to reduce the household economic burden of @entity1 . METHODS: We systematically reviewed reports published on or before 31 January 2014 that we found in the CENTRAL, CINAHL, Econlit, Embase, MEDLINE, PreMEDLINE and PsycINFO databases. We extracted data from prospective controlled trials and assessed the risk of bias. We narratively synthesized evidence. FINDINGS: Nine of the 4330 studies checked met our inclusion criteria - seven had evaluated changes to existing health-insurance programmes and two had evaluated different modes of delivering information. The only interventions found to reduce out-of-pocket expenditure significantly were those that eliminated or substantially reduced co-payments for a given @entity0 population. However, the reductions only represented marginal changes in the total expenditures of @entity0 . We found no studies that had been effective in addressing broader household economic impacts - such as catastrophic health expenditure - in the disease populations investigated. CONCLUSION: In general, interventions designed to reduce the complex household economic burden of @entity1 appear to have had little impact on household economies. We only found a few relevant studies using rigorous study designs that were conducted in defined @entity0 populations. The studies were limited in the range of interventions tested and they evaluated only a narrow range of household economic outcomes. There is a need for method development to advance the measurement of the household economic consequences of @entity1 and facilitate the development of innovative interventions to supplement the strategies based on health insurance.

title: The effectiveness of interventions to reduce the household economic burden of XXXX : a systematic review.

answer: @entity1


abstract: OBJECTIVES: To compare the effectiveness, side effects, and @entity0 satisfaction of buccal versus vaginal @entity2 administration in first and second trimester induced abortions. METHODS: In first trimester, @entity0 received oral @entity3 followed by @entity2 either by buccal or vaginal route. In second trimester, @entity0 received oral @entity3 followed by repeated doses of @entity2 either by buccal or vaginal route. A comparative analysis using SPSS was done. RESULTS: In first trimester, success rate of medical abortion was 96  % in buccal group and 88  % in vaginal group. @entity1 was the most common adverse effect which was similar in both groups. In second trimester, success rate was 96  % in buccal group and 80  % in vaginal group. A statistically higher incidence of @entity1 was noticed in buccal group. @entity0 satisfaction level was almost similar in both the groups in both trimesters. CONCLUSIONS: Buccal and vaginal routes of @entity2 administration have similar efficacy and @entity0 satisfaction level for first and second trimester induced abortions. Hence, buccal route may serve as an alternative to vaginal @entity2 .

title: Buccal versus vaginal XXXX administration for the induction of first and second trimester abortions.

answer: @entity2


abstract: Aim. Differentiation of malignant and benign strictures constitutes a problem despite the increasing experience of the endoscopists, radiologists, and pathologists. The aim of our study is to determine the factors that affect the efficacy of the ERCP guided brush cytology in PBS and to evaluate its diagnostic success when used alone and together with @entity1 markers. Method. The data from brush cytologies of 301 PBS @entity0 were collected retrospectively and analyzed. The final diagnosis was approved based on the histological examination of the tissue taken surgically or by other methods. In the absence of a histological diagnosis, the final diagnosis was based on radiological studies or the results of a 12-month clinical follow up. Results. A total of 28 @entity0 were excluded from the study. From the remaining 273 @entity0 299 samples were analyzed. The sensitivity and the specificity of brush cytology in diagnosing @entity1 are 62.4% and 97.7, respectively. The sensitivity of brush cytology increased to 94.1% when combined with CA-19.9 and CA-125. Conclusion. Brush cytology is a useful method in diagnosing pancreaticobiliary strictures. Advanced age, stricture dilatation before sampling, the presence of a mass identified by radiological studies, high levels of CA-19.9, ALT, and total @entity2 increase the sensitivity of brush cytology.

title: The diagnostic value of brush cytology alone and in combination with XXXX markers in pancreaticobiliary strictures.

answer: @entity1


abstract: @entity3 ( @entity3 ) is increasingly used by @entity0 with @entity2 ( @entity2 ); however, there has been no systematic evaluation of its safety. This review examined the adverse events (AEs) reported in clinical studies of @entity3 for @entity2 . Five English databases (PubMed, Embase, CINAHL, AMED, and CENTRAL) and four Chinese databases (CBM, CNKI, CQVIP, and Wanfang Data) were searched from inception to May 2013. Adverse event data, including nature, severity, author-assigned causality, management, and outcome, were extracted from included studies. Descriptive statistics were used for the rate of adverse events. Of the 152 included studies, AEs were reported in 47 studies. The rate of adverse events was slightly lower in the @entity3 groups compared with controls (84 events in 5,909 @entity0 , 1.4% versus 102 events in 5,676 @entity0 , 1.8%). The most frequently reported adverse event was @entity1 (28 cases in the @entity3 groups and 19 cases in the control groups), which was more common in studies where @entity3 was combined with pharmacotherapy to treat acute exacerbation of @entity2 . Other frequent adverse events were abdominal discomfort, @entity5 , and @entity4 . Detailed information about the adverse events was scant. Overall, @entity3 appears to be well tolerated in @entity0 with @entity2 .

title: Safety of chinese herbal medicine for XXXX .

answer: @entity2


abstract: BACKGROUND: The detection of circulating DNA is considered a promising strategy in @entity1 @entity0 . Digital PCR has emerged as a sensitive method able to quantify both circulating free and @entity1 DNA. AIM: The aim of this study was to prospectively evaluate the clinical value of a chip-based digital PCR for the detection of circulating DNA. METHODS: Digital PCR was used in 34 metastatic @entity2 @entity0 to detect and quantify circulating free and @entity1 DNA based on @entity3 mutational status. Clinical outcomes were analyzed according to circulating DNA measurements. RESULTS: Digital PCR yielded a detection rate of 69% for circulating @entity1 DNA. The median concentrations of circulating free and @entity1 DNA were 20 and 6.8ng/mL, respectively, with significant correlation between both biomarkers (p<0.001). Median overall survival was 4.8 months in @entity0 with high circulating free DNA (>75% quartile) versus not reached in @entity0 with a low level (<25% quartile) (p=0.029). Moreover, median overall survival was significantly decreased in @entity0 with detectable circulating @entity1 DNA compared to those without (respectively 11.8 months versus not reached, p=0.04). CONCLUSIONS: Chip-based digital PCR is a simple and non-invasive method allowing the efficient detection of circulating DNA. Our results highlight that levels of these circulating markers may have a potential prognostic value.

title: Clinical value of chip-based digital-PCR platform for the detection of circulating DNA in metastatic XXXX .

answer: @entity2


abstract: Subtle changes in social cognition are associated with naturalistic fluctuations in @entity4 and @entity6 over the course of the menstrual cycle. Using a dynamic emotion recognition task we aimed to provide a comprehensive description of the association between ovarian hormone levels and emotion recognition performance using a variety of performance metrics. Naturally cycling, @entity2 healthy @entity0 attended a single experimental session during a follicular (days 7-13; n = 16), early luteal (days 15-19; n = 14) or late luteal phase (days 22-27; n = 14) of their menstrual cycle. Correct responses and reaction times to dynamic facial expressions were recorded and a two-high threshold analysis was used to assess discrimination and response bias. Salivary @entity6 and @entity1 were assayed and subjective measures of @entity5 , @entity3 and positive and negative affect assessed. There was no interaction between cycle phase (follicular, early luteal, late luteal) and facial expression (sad, happy, fearful, angry, neutral and disgusted) on any of the recognition performance metrics. However, across the sample as a whole, @entity6 levels were positively correlated with reaction times to a variety of facial expressions (anger, happiness, sadness and neutral expressions). In contrast, @entity1 levels were specifically correlated with disgust processing on three performance indices (correct responses, response bias and discrimination). @entity5 , @entity3 and positive and negative affect were not associated with emotion recognition indices or hormone levels. The study highlights the role of naturalistic variations in ovarian hormone levels in modulating emotion recognition. In particular, @entity6 seems to have a general slowing effect on facial expression processing. Our findings also provide the first behavioural evidence of a specific role for @entity4 in the processing of disgust in @entity0 .

title: A specific association between facial disgust recognition and XXXX levels in naturally cycling @entity0 .

answer: @entity1


abstract: Subtle changes in social cognition are associated with naturalistic fluctuations in @entity4 and @entity6 over the course of the menstrual cycle. Using a dynamic emotion recognition task we aimed to provide a comprehensive description of the association between ovarian hormone levels and emotion recognition performance using a variety of performance metrics. Naturally cycling, @entity2 healthy @entity0 attended a single experimental session during a follicular (days 7-13; n = 16), early luteal (days 15-19; n = 14) or late luteal phase (days 22-27; n = 14) of their menstrual cycle. Correct responses and reaction times to dynamic facial expressions were recorded and a two-high threshold analysis was used to assess discrimination and response bias. Salivary @entity6 and @entity1 were assayed and subjective measures of @entity5 , @entity3 and positive and negative affect assessed. There was no interaction between cycle phase (follicular, early luteal, late luteal) and facial expression (sad, happy, fearful, angry, neutral and disgusted) on any of the recognition performance metrics. However, across the sample as a whole, @entity6 levels were positively correlated with reaction times to a variety of facial expressions (anger, happiness, sadness and neutral expressions). In contrast, @entity1 levels were specifically correlated with disgust processing on three performance indices (correct responses, response bias and discrimination). @entity5 , @entity3 and positive and negative affect were not associated with emotion recognition indices or hormone levels. The study highlights the role of naturalistic variations in ovarian hormone levels in modulating emotion recognition. In particular, @entity6 seems to have a general slowing effect on facial expression processing. Our findings also provide the first behavioural evidence of a specific role for @entity4 in the processing of disgust in @entity0 .

title: A specific association between facial disgust recognition and @entity1 levels in naturally cycling XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity4 ( @entity4 ) is an acute self-limited disease of childhood, mostly resolving within 6 months irrespective of whether therapy is given or not. Treatment options when indicated include corticosteroids, intravenous immune globulin (IVIG), and anti- @entity5 immunoglobulin. We reviewed our 32  years' experience for first-line therapy of acute @entity4 . Five hundred forty-one @entity0 (mean age: 5.3  years) diagnosed and treated for @entity4 were evaluated retrospectively. Among 491 acute @entity4 @entity0 , IVIG was used in 27%, high-dose @entity1 in 27%, low-dose @entity1 in 20%, anti-D immunoglobulin G (IgG) in 2%, and no therapy in 22%. When the initial response (platelets >50 * 10(9)/L) to first-line treatment modalities were compared, 89%, 84%, and 78% @entity0 treated by low-dose @entity1 , high-dose @entity1 , and IVIG responded to treatment, respectively (P > .05). Mean time to recovery of platelets was 16.8, 3.8, and 3.0  days in @entity0 treated with low-dose @entity1 , high-dose @entity1 , and IVIG, respectively (P < .0001). @entity3 recurred in 23% of low-dose @entity2 , 39% of high-dose @entity2 , and in 36% of IVIG (P < .0001) treatment groups. Of 108 @entity0 who were observed alone, 4 (3%) had a recurrence on follow-up and only 2 of these required treatment subsequently. Recurrence was significantly less in no therapy group compared with @entity0 treated with 1 of the 3 options of pharmacotherapy (P < .0001). Response rates were similar between @entity0 treated by IVIG and low- and high-dose @entity1 ; however, time to response was slower in @entity0 treated with low-dose @entity1 compared with IVIG and high-dose @entity1 .

title: Initial Management of Childhood Acute XXXX : Single-Center Experience of 32 Years.

answer: @entity4


abstract: The lipid composition of the serum lipoproteins of @entity1 with varying degrees of @entity3 was investigated. The concentrations of all the lipoproteins were increased with increasing @entity3 . The elevation was found to be more pronounced for very low density VLDL) and low density (LDL) than for high density lipoproteins (HDL). A linear relationship exists between @entity4 and @entity2 contents of VLDL fractions independent of the VLDL level. Eighty to ninety per cent of serum @entity5 are located in the VLDL fraction. Linear relationships were found between the levels of serum @entity5 or VLDL @entity5 and the levels of LDL and HDL @entity2 , respectively. Furthermore, linear relationships exist between total @entity2 content in serum and @entity2 concentration in VLDL, LDL and HDL, respectively. Thus, lipoprotein levels may be estimated by measuring serum @entity2 or @entity4 concentrations. Disk electrophoresis and ultracentrifugation revealed that the LDL fraction (d. 1.006 - 1.063) could be divided into two fractions, which both increase with age. The spontaneous @entity6 of the old @entity1 make these animals suitable as a model for evaluation of drugs against @entity0 @entity6 .

title: Studies on serum lipoproteins of @entity1 developing spontaneous XXXX .

answer: @entity3


abstract: The lipid composition of the serum lipoproteins of @entity1 with varying degrees of @entity3 was investigated. The concentrations of all the lipoproteins were increased with increasing @entity3 . The elevation was found to be more pronounced for very low density VLDL) and low density (LDL) than for high density lipoproteins (HDL). A linear relationship exists between @entity4 and @entity2 contents of VLDL fractions independent of the VLDL level. Eighty to ninety per cent of serum @entity5 are located in the VLDL fraction. Linear relationships were found between the levels of serum @entity5 or VLDL @entity5 and the levels of LDL and HDL @entity2 , respectively. Furthermore, linear relationships exist between total @entity2 content in serum and @entity2 concentration in VLDL, LDL and HDL, respectively. Thus, lipoprotein levels may be estimated by measuring serum @entity2 or @entity4 concentrations. Disk electrophoresis and ultracentrifugation revealed that the LDL fraction (d. 1.006 - 1.063) could be divided into two fractions, which both increase with age. The spontaneous @entity6 of the old @entity1 make these animals suitable as a model for evaluation of drugs against @entity0 @entity6 .

title: Studies on serum lipoproteins of XXXX developing spontaneous @entity3 .

answer: @entity1


abstract: OBJECTIVE: To assess the efficacy of autologous blood injections (ABIs) against saline in @entity0 with @entity1 (PT). DESIGN: Double-blind randomized controlled study. SETTING: Homerton Hospital Sports Medicine department. @entity0 : Those with a diagnosis of @entity1 were recruited between March 2010 and March 2012. INTERVENTIONS: Using 2 practitioners, @entity0 were randomized to either receive ABIs or saline injections. MAIN OUTCOME MEASURES: All @entity0 completed the Short-Form McGill Pain Questionnaire (MPQ), a visual analog scale (VAS), and a Victoria Institute of Sport Assessment for Patella @entity1 scale over a 12-month period. RESULTS: Twenty-two @entity0 completed the final review at 12 months and were included in the study. Subjects ranged in age from 22 and 61 years and were randomized to 11 in each ABI and saline groups. Autologous blood injection group had a mean duration of symptoms of 16.7 months, whereas that of the saline group was 19.2 months. The saline group mean VAS score was reduced from 7.9 to 4.5 at 1 month (P = 0.003) and 3.3 (P = 0.005) at 1 year. With ABI, the score was reduced from 7.5 to 4.5 (P = 0.005) at 1 month and 3.1 (P = 0.003) at 1 year. Victoria Institute of Sport Assessment for Patella @entity1 , MPQ, and VAS scores improved significantly in both groups. CONCLUSIONS: This study demonstrated that both the ABI and saline groups experienced a significant improvement in symptoms. However, when the results were compared, there was no statistical difference between the 2 groups. CLINICAL RELEVANCE: This research showed that tendon fenestration is an alternative cost-effective treatment for recalcitrant PT.

title: Double-Blind Randomized Controlled Trial: Injection of Autologous Blood in the Treatment of XXXX -A Pilot Study.

answer: @entity1


abstract: @entity7 ( @entity7 ) is clinically characterized by progressive @entity4 that is frequently accompanied by neurological and @entity2 manifestations. @entity13 ( @entity13 ) is a rare @entity5 with neurological and @entity2 manifestations that is not well understood. However, this disease has attracted growing attention as a treatable @entity4 . Although autoimmune mechanisms are thought to play a pathogenic role in @entity13 , the etiology of the disease remains unclear. Recently, it was reported that the serum in @entity0 with @entity13 is frequentry positive for autoantibodies against the anti- @entity11 2-terminal of a-enolase (anti-NAE), indicating a useful serological diagnostic marker for @entity13 . We report the case of an 81-year-old Japanese @entity0 with probable @entity7 and @entity6 . In her serum, elevated anti-thyroid antibodies and positive autoantibodies against anti-NAE were observed. Elevated levels of anti- @entity10 receptor   2 subunit ( @entity12 ) antibodies were also detected in her cerebrospinal fluid. Because her clinical condition became stable after treatment with cholinesterase inhibitor, @entity9 , and @entity8 , immunotherapy was not performed. Although the relationship between @entity5 and @entity1 in this @entity0 was unclear, the present observations suggest the coexistence of @entity3 and @entity5 as the underlying pathogenic mechanism. (Received March 3, 2014; Accepted February 17, 2015; Published July 1, 2015).

title: [A @entity0 with Probable @entity4 with Lewy Bodies and Positive Autoantibodies against the Anti- XXXX 2-terminal of a-Enolase].

answer: @entity11


abstract: @entity7 ( @entity7 ) is clinically characterized by progressive @entity4 that is frequently accompanied by neurological and @entity2 manifestations. @entity13 ( @entity13 ) is a rare @entity5 with neurological and @entity2 manifestations that is not well understood. However, this disease has attracted growing attention as a treatable @entity4 . Although autoimmune mechanisms are thought to play a pathogenic role in @entity13 , the etiology of the disease remains unclear. Recently, it was reported that the serum in @entity0 with @entity13 is frequentry positive for autoantibodies against the anti- @entity11 2-terminal of a-enolase (anti-NAE), indicating a useful serological diagnostic marker for @entity13 . We report the case of an 81-year-old Japanese @entity0 with probable @entity7 and @entity6 . In her serum, elevated anti-thyroid antibodies and positive autoantibodies against anti-NAE were observed. Elevated levels of anti- @entity10 receptor   2 subunit ( @entity12 ) antibodies were also detected in her cerebrospinal fluid. Because her clinical condition became stable after treatment with cholinesterase inhibitor, @entity9 , and @entity8 , immunotherapy was not performed. Although the relationship between @entity5 and @entity1 in this @entity0 was unclear, the present observations suggest the coexistence of @entity3 and @entity5 as the underlying pathogenic mechanism. (Received March 3, 2014; Accepted February 17, 2015; Published July 1, 2015).

title: [A @entity0 with Probable XXXX with Lewy Bodies and Positive Autoantibodies against the Anti- @entity11 2-terminal of a-Enolase].

answer: @entity4


abstract: @entity7 ( @entity7 ) is clinically characterized by progressive @entity4 that is frequently accompanied by neurological and @entity2 manifestations. @entity13 ( @entity13 ) is a rare @entity5 with neurological and @entity2 manifestations that is not well understood. However, this disease has attracted growing attention as a treatable @entity4 . Although autoimmune mechanisms are thought to play a pathogenic role in @entity13 , the etiology of the disease remains unclear. Recently, it was reported that the serum in @entity0 with @entity13 is frequentry positive for autoantibodies against the anti- @entity11 2-terminal of a-enolase (anti-NAE), indicating a useful serological diagnostic marker for @entity13 . We report the case of an 81-year-old Japanese @entity0 with probable @entity7 and @entity6 . In her serum, elevated anti-thyroid antibodies and positive autoantibodies against anti-NAE were observed. Elevated levels of anti- @entity10 receptor   2 subunit ( @entity12 ) antibodies were also detected in her cerebrospinal fluid. Because her clinical condition became stable after treatment with cholinesterase inhibitor, @entity9 , and @entity8 , immunotherapy was not performed. Although the relationship between @entity5 and @entity1 in this @entity0 was unclear, the present observations suggest the coexistence of @entity3 and @entity5 as the underlying pathogenic mechanism. (Received March 3, 2014; Accepted February 17, 2015; Published July 1, 2015).

title: [A XXXX with Probable @entity4 with Lewy Bodies and Positive Autoantibodies against the Anti- @entity11 2-terminal of a-Enolase].

answer: @entity0


abstract: RATIONALE: Notwithstanding the uncertainties about the outcomes of bone marrow cell (BMC) therapy for heart repair, further insights are critically needed to improve this promising approach. OBJECTIVE: To delineate the true effect of BMC therapy for cardiac repair and gain insights for future trials through systematic review and meta-analysis of data from eligible randomized controlled trials. METHODS AND RESULTS: Database searches through August 2014 identified 48 eligible randomized controlled trials (enrolling 2602 @entity0 ). Weighted mean differences for changes in left ventricular (LV) ejection fraction, @entity5 size, LV end-systolic volume, and LV end-diastolic volume were analyzed with random-effects meta-analysis. Compared with standard therapy, BMC transplantation improved LV ejection fraction (2.92%; 95% confidence interval, 1.91-3.92; P<0.00001), reduced @entity5 size (-2.25%; 95% confidence interval, -3.55 to -0.95; P=0.0007) and LV end-systolic volume (-6.37 mL; 95% confidence interval, -8.95 to -3.80; P<0.00001), and tended to reduce LV end-diastolic volume (-2.26 mL; 95% confidence interval, -4.59 to 0.07; P=0.06). Similar effects were noted when data were analyzed after excluding studies with discrepancies in reporting of outcomes. The benefits also persisted when cardiac catheterization was performed in control @entity0 as well. Although imaging modalities partly influenced the outcomes, LV ejection fraction improved in BMC-treated @entity0 when assessed by magnetic resonance imaging. Early (<48 hours) BMC injection after @entity2 was more effective in reducing @entity5 size, whereas BMC injection between 3 and 10 days proved superior toward improving systolic function. A minimum of 50 million BMCs seemed to be necessary, with limited additional benefits seen with increasing cell numbers. BMC therapy was safe and improved clinical outcomes, including all-cause mortality, recurrent @entity2 , @entity4 , and cerebrovascular accident during follow-up, albeit with differences between @entity2 and @entity3 subgroups. CONCLUSIONS: Transplantation of adult BMCs improves LV ejection fraction, reduces @entity5 size, and ameliorates remodeling in @entity0 with @entity3 . These effects are upheld in the analyses of studies using magnetic resonance imaging and also after excluding studies with discrepant reporting of outcomes. BMC transplantation may also reduce the incidence of @entity1 , recurrent @entity2 , @entity4 , and cerebrovascular accident during follow-up.

title: Adult Bone Marrow Cell Therapy for XXXX : Evidence and Insights From Randomized Controlled Trials.

answer: @entity3


abstract: BACKGROUND: Hibiscus sabdariffa L. is a tropical wild plant rich in organic acids, @entity3 , @entity2 , polysaccharides, and volatile constituents that are beneficial for the cardiovascular system. Hibiscus sabdariffa beverages are commonly consumed to treat arterial @entity1 , yet the evidence from randomized controlled trials (RCTs) has not been fully conclusive. Therefore, we aimed to assess the potential antihypertensive effects of H. sabdariffa through systematic review of literature and meta-analysis of available RCTs. METHODS: The search included PUBMED, Cochrane Library, Scopus, and EMBASE (up to July 2014) to identify RCTs investigating the efficacy of H. sabdariffa supplementation on @entity4 and @entity5 values. Two independent reviewers extracted data on the study characteristics, methods, and outcomes. Quantitative data synthesis and meta-regression were performed using a fixed-effect model, and sensitivity analysis using leave-one-out method. Five RCTs (comprising seven treatment arms) were selected for the meta-analysis. In total, 390 @entity0 were randomized, of whom 225 were allocated to the H. sabdariffa supplementation group and 165 to the control group in the selected studies. RESULTS: Fixed-effect meta-regression indicated a significant effect of H. sabdariffa supplementation in lowering both @entity4 (weighed mean difference -7.58mmHg, 95% confidence interval -9.69 to -5.46, P<0.00001) and @entity5 (weighed mean difference -3.53mmHg, 95% confidence interval -5.16 to -1.89, P<0.0001). These effects were inversely associated with baseline BP values, and were robust in sensitivity analyses. CONCLUSION: This meta-analysis of RCTs showed a significant effect of H. sabdariffa in lowering both @entity4 and @entity5 . Further well designed trials are necessary to validate these results.

title: Effect of sour tea (Hibiscus sabdariffa L.) on arterial XXXX : a systematic review and meta-analysis of randomized controlled trials.

answer: @entity1


abstract: BACKGROUND/AIMS: The gastrointestinal (GI) tract often becomes involved in @entity0 with @entity8 . As few @entity2 data have been reported, we describe the clinical features and outcomes of @entity0 with pathologically proven @entity2 . METHODS: We identified 155 @entity0 diagnosed with @entity8 between April 1995 and April 2013. Twenty-four @entity0 (15.5%) were diagnosed with @entity2 using associated symptoms, and the diagnoses were confirmed by direct biopsy. RESULTS: Among the 24 @entity0 , 20 (83.3%) had @entity9 ( @entity9 ), three (12.5%) had @entity5 , and one (4.2%) had transthyretin-related @entity9 . Their median age was 57 years (range, 37 to 72), and 10 @entity0 were female (41.7%). The most common symptoms of @entity2 were @entity1 (11 @entity0 , 45.8%), followed by @entity4 (nine @entity0 , 37.5%), @entity3 , and @entity6 (seven @entity0 , 29.2%). The histologically confirmed GI tract site in @entity9 was the stomach in 11 @entity0 (55.0%), the colon in nine (45.0%), the rectum in seven (35.0%), and the small bowel in one (5.0%). @entity0 with @entity2 had a greater frequency of organ involvement (p = 0.014). Median @entity7 ( @entity7 ) in @entity0 with @entity2 was shorter (7.95 months; range, 0.3 to 40.54) than in those without @entity2 (15.84 months; range, 0.0 to 114.53; p = 0.069) in a univariate analysis. A multivariate analysis of prognostic factors for @entity9 revealed that @entity2 was not a significant predictor of @entity7 (p = 0.447). CONCLUSIONS: The prognosis of @entity0 with @entity9 was poorer than those without @entity2 , and they presented with more organ involvement and more advanced disease than those without organ involvement.

title: Clinical features and outcomes of @entity8 with XXXX : a single-center experience.

answer: @entity2


abstract: BACKGROUND/AIMS: The gastrointestinal (GI) tract often becomes involved in @entity0 with @entity8 . As few @entity2 data have been reported, we describe the clinical features and outcomes of @entity0 with pathologically proven @entity2 . METHODS: We identified 155 @entity0 diagnosed with @entity8 between April 1995 and April 2013. Twenty-four @entity0 (15.5%) were diagnosed with @entity2 using associated symptoms, and the diagnoses were confirmed by direct biopsy. RESULTS: Among the 24 @entity0 , 20 (83.3%) had @entity9 ( @entity9 ), three (12.5%) had @entity5 , and one (4.2%) had transthyretin-related @entity9 . Their median age was 57 years (range, 37 to 72), and 10 @entity0 were female (41.7%). The most common symptoms of @entity2 were @entity1 (11 @entity0 , 45.8%), followed by @entity4 (nine @entity0 , 37.5%), @entity3 , and @entity6 (seven @entity0 , 29.2%). The histologically confirmed GI tract site in @entity9 was the stomach in 11 @entity0 (55.0%), the colon in nine (45.0%), the rectum in seven (35.0%), and the small bowel in one (5.0%). @entity0 with @entity2 had a greater frequency of organ involvement (p = 0.014). Median @entity7 ( @entity7 ) in @entity0 with @entity2 was shorter (7.95 months; range, 0.3 to 40.54) than in those without @entity2 (15.84 months; range, 0.0 to 114.53; p = 0.069) in a univariate analysis. A multivariate analysis of prognostic factors for @entity9 revealed that @entity2 was not a significant predictor of @entity7 (p = 0.447). CONCLUSIONS: The prognosis of @entity0 with @entity9 was poorer than those without @entity2 , and they presented with more organ involvement and more advanced disease than those without organ involvement.

title: Clinical features and outcomes of XXXX with @entity2 : a single-center experience.

answer: @entity8


abstract: We investigated the protective effects and mechanism of @entity4 ( @entity9 ) on vascular @entity10 induced by bile duct ligation (BDL) in a @entity0 model. Seventy-two male @entity0 were randomly divided into four groups: a NS group, a @entity9 group, a BDL + NS group, and a BDL + @entity9 group. @entity9 was administrated into @entity0 in the @entity9 and BDL + @entity9 groups by gastric gavage. An equal volume of normal saline was, respectively, given in the NS group and BDL + NS group. Blood was gathered for serological determination and thoracic aorta rings were isolated for measurement of isometric tension. @entity8 led to a significant increase in the serum total @entity1 , AST, and ALT levels. The proinflammatory cytokines levels ( @entity2 and @entity5 ), concentration of NO, and oxidative stress markers ( @entity3 and 3-NT) were increased as well. All of those were reduced by the treatment of @entity9 . Meanwhile, contraction of aorta rings to NA and vasorelaxation to @entity6 or SNP in the BDL group @entity0 were markedly decreased, while @entity9 administration reversed this change. Our findings suggested that @entity9 supplementation attenuated overexpressed @entity11 from the reaction of excessive NO with @entity7 (   -) and protected against @entity8 -induced vascular @entity10 in @entity0 .

title: @entity4 Supplementation Attenuates Oxidative Stress and Improves Vascular XXXX in @entity8 .

answer: @entity10


abstract: We investigated the protective effects and mechanism of @entity4 ( @entity9 ) on vascular @entity10 induced by bile duct ligation (BDL) in a @entity0 model. Seventy-two male @entity0 were randomly divided into four groups: a NS group, a @entity9 group, a BDL + NS group, and a BDL + @entity9 group. @entity9 was administrated into @entity0 in the @entity9 and BDL + @entity9 groups by gastric gavage. An equal volume of normal saline was, respectively, given in the NS group and BDL + NS group. Blood was gathered for serological determination and thoracic aorta rings were isolated for measurement of isometric tension. @entity8 led to a significant increase in the serum total @entity1 , AST, and ALT levels. The proinflammatory cytokines levels ( @entity2 and @entity5 ), concentration of NO, and oxidative stress markers ( @entity3 and 3-NT) were increased as well. All of those were reduced by the treatment of @entity9 . Meanwhile, contraction of aorta rings to NA and vasorelaxation to @entity6 or SNP in the BDL group @entity0 were markedly decreased, while @entity9 administration reversed this change. Our findings suggested that @entity9 supplementation attenuated overexpressed @entity11 from the reaction of excessive NO with @entity7 (   -) and protected against @entity8 -induced vascular @entity10 in @entity0 .

title: XXXX Supplementation Attenuates Oxidative Stress and Improves Vascular @entity10 in @entity8 .

answer: @entity4


abstract: We investigated the protective effects and mechanism of @entity4 ( @entity9 ) on vascular @entity10 induced by bile duct ligation (BDL) in a @entity0 model. Seventy-two male @entity0 were randomly divided into four groups: a NS group, a @entity9 group, a BDL + NS group, and a BDL + @entity9 group. @entity9 was administrated into @entity0 in the @entity9 and BDL + @entity9 groups by gastric gavage. An equal volume of normal saline was, respectively, given in the NS group and BDL + NS group. Blood was gathered for serological determination and thoracic aorta rings were isolated for measurement of isometric tension. @entity8 led to a significant increase in the serum total @entity1 , AST, and ALT levels. The proinflammatory cytokines levels ( @entity2 and @entity5 ), concentration of NO, and oxidative stress markers ( @entity3 and 3-NT) were increased as well. All of those were reduced by the treatment of @entity9 . Meanwhile, contraction of aorta rings to NA and vasorelaxation to @entity6 or SNP in the BDL group @entity0 were markedly decreased, while @entity9 administration reversed this change. Our findings suggested that @entity9 supplementation attenuated overexpressed @entity11 from the reaction of excessive NO with @entity7 (   -) and protected against @entity8 -induced vascular @entity10 in @entity0 .

title: @entity4 Supplementation Attenuates Oxidative Stress and Improves Vascular @entity10 in XXXX .

answer: @entity8


abstract: Background. Traditional uvulectomy is performed as a cultural @entity4 . We describe the associated @entity2 ( @entity2 ) presentations and outcomes. Methods. This was a subgroup analysis of a retrospective review of all pediatric visits to our @entity2 in 2012. Trained abstracters recorded demographics, clinical presentations, and outcomes. Results. Complete data were available for 5540/5774 (96%) visits and 56 (1.0%, 95% CI: 0.7-1.3%) were related to recent uvulectomy, median age 1.3 years (interquartile range: 7 months-2 years) and 30 (54%) were male. Presenting complaints included cough (82%), @entity1 (46%), and @entity5 (38%). Clinical findings included @entity1 (54%), @entity6 (30%), and @entity3 (25%). 35 @entity0 (63%, 95% CI: 49-75%) received intravenous antibiotics, 11 (20%, 95% CI: 10-32%) required blood transfusion, and 3 (5%, 95% CI: 1-15%) had surgical intervention. All were admitted to the hospital and 12 (21%, 95% CI: 12-34%) died. By comparison, 498 (9.1%, 95% CI: 8-10%) of the 5484 @entity0 presenting for reasons unrelated to uvulectomy died (p = 0.003). Conclusion. In our cohort, traditional uvulectomy was associated with significant morbidity and mortality. Emergency care providers should advocate for legal and public health interventions to eliminate this dangerous practice.

title: Morbidity and Mortality following Traditional Uvulectomy among XXXX Presenting to the Muhimbili National Hospital Emergency Department in Dar es Salaam, Tanzania.

answer: @entity0


abstract: OBJECTIVE: Molecular diagnosis for subjects with extremely low HDL-C through candidate-gene approaches requires huge effort. Whole exome-sequencing (WES) has already shown approximately    30% success in the diagnosis of @entity0 . Moreover, novel in silico prediction software for the pathogenicity of novel missense variants named Combined Annotation Dependent Depletion (CADD) has recently been developed, enabling the objective integration of many diverse annotations into a single measure (C-score) for each variant. Here, we investigated whether WES combined with integrated variant annotation prediction could facilitate the molecular diagnosis of this rare condition. METHODS: WES was performed on 8 individuals including 2 individuals exhibiting extremely low HDL-C (2  mg/dl and 6  mg/dl), 2 unaffected family members, and 4 unrelated individuals as controls. We filtered out the following variants: 1) Benign variants predicted by SnpEff; 2) @entity3 ) Segregation unmatched for the recessive form of inheritance; 4) C-score  <  10. RESULTS: Among 305,202 variants found in those individuals, we found 21,708 nonsense, missense, or splice site variants, of which 5192 were rare (MAF   <=  1% or not reported). Filtering assuming a recessive pattern of inheritance, combined with the use of the C-score, successfully narrowed down the candidates to compound heterozygous mutations in the @entity2 gene ( @entity4 or @entity5 / @entity6 or @entity7 , and @entity8 or @entity9 / @entity10 or @entity11 ). CONCLUSIONS: WES combined with integrated variant annotation prediction successfully identified asymptomatic @entity1 with novel @entity2 mutations. This comprehensive approach is useful to determine causative variants, especially in @entity0 .

title: Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic @entity1 with compound heterozygous mutations in XXXX gene.

answer: @entity2


abstract: OBJECTIVE: Molecular diagnosis for subjects with extremely low HDL-C through candidate-gene approaches requires huge effort. Whole exome-sequencing (WES) has already shown approximately    30% success in the diagnosis of @entity0 . Moreover, novel in silico prediction software for the pathogenicity of novel missense variants named Combined Annotation Dependent Depletion (CADD) has recently been developed, enabling the objective integration of many diverse annotations into a single measure (C-score) for each variant. Here, we investigated whether WES combined with integrated variant annotation prediction could facilitate the molecular diagnosis of this rare condition. METHODS: WES was performed on 8 individuals including 2 individuals exhibiting extremely low HDL-C (2  mg/dl and 6  mg/dl), 2 unaffected family members, and 4 unrelated individuals as controls. We filtered out the following variants: 1) Benign variants predicted by SnpEff; 2) @entity3 ) Segregation unmatched for the recessive form of inheritance; 4) C-score  <  10. RESULTS: Among 305,202 variants found in those individuals, we found 21,708 nonsense, missense, or splice site variants, of which 5192 were rare (MAF   <=  1% or not reported). Filtering assuming a recessive pattern of inheritance, combined with the use of the C-score, successfully narrowed down the candidates to compound heterozygous mutations in the @entity2 gene ( @entity4 or @entity5 / @entity6 or @entity7 , and @entity8 or @entity9 / @entity10 or @entity11 ). CONCLUSIONS: WES combined with integrated variant annotation prediction successfully identified asymptomatic @entity1 with novel @entity2 mutations. This comprehensive approach is useful to determine causative variants, especially in @entity0 .

title: Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic XXXX with compound heterozygous mutations in @entity2 gene.

answer: @entity1


abstract: OBJECTIVE: To investigate the relationship between changes in @entity0 attributes and hospital attributes over time and to explore predictors of medical utilization and mortality rates in @entity1 ( @entity1 ) @entity0 in Taiwan. BACKGROUND: Providing effective medical care for @entity1 @entity0 is challenging and requires good planning and effective clinical decision making policies. Most studies of @entity1 , however, have only analyzed a single regional ventilator weaning center or respiratory care unit, high-quality population-based studies of @entity1 trends and outcomes are scarce. METHODS: This population-based cohort study retrospectively analyzed 213,945 @entity1 @entity0 treated during 2004-2009. RESULTS: During the study period, the percentages of @entity1 @entity0 with the following characteristics significantly increased: age     65 years, treatment at a medical center, and treatment by a high-volume physician. In contrast, the percentages of @entity1 @entity0 treated at local hospitals and by low-volume physicians significantly decreased (P<0.001). Age, gender, Deyo-Charlson co-morbidity index, teaching hospital, hospital level, hospital volume, and physician volume were significantly associated with @entity1 outcome (P<0.001). Over the 6-year period analyzed in this study, the estimated mean hospital treatment cost increased 48.8% whereas mean length of stay decreased 13.9%. The estimated mean overall survival time for @entity1 @entity0 was 16.4 months (SD 0.4 months), and the overall in-hospital 1-, 3-, and 5-year survival rates were 61.0%, 36.7%, 17.3%, and 9.6%, respectively. CONCLUSIONS: These population-based data revealed increases in the percentages of @entity1 @entity0 treated at medical centers and by high-volume physicians, especially in younger @entity0 . Notably, although LOS for @entity1 @entity0 decreased, hospital treatment costs increased. Healthcare providers and @entity0 should recognize that attributes of both the @entity0 and the hospital may affect outcomes.

title: Trend analysis and outcome prediction in mechanically ventilated XXXX : a nationwide population-based study in Taiwan.

answer: @entity0


abstract: BACKGROUND: After masseteric-facial nerve (V-VII) @entity1 , a new neurological circuit oversees the facial muscles and @entity0 should learn to activate the facial movements using the masseteric function. AIM: To monitor the rehabilitative protocol of facial muscles activation through teeth @entity4 and to assess the clinical evolution after V-VII @entity1 in terms of facial symmetry and functional recovery. DESIGN: Case series. SETTING: Outpatients clinic. POPULATION: Eleven @entity0 undergone V-VII @entity1 for complete unilateral @entity3 . METHODS: After surgery, @entity0 underwent a needle electromyography (EMG) and a rehabilitative training with mirror feedback to learn how to reach the symmetry at rest and during facial movements through teeth @entity4 . The rehabilitative protocol at the first clinical evaluation has been monitored through the Italian version of Sunnybrook Facial Grading System (SFGS) and the Software Facial Assessment by Computer Evaluation (FACE). Functional limitations and quality of life have been evaluated using the Italian version of @entity2 Index (FDI). The clinical evolution at 18 months was evaluated with EMG, SFGS, biting evaluation and FDI. RESULTS: At the first clinical evaluation after reinnervation, through teeth @entity4 @entity0 displayed an improvement of symmetry at rest, symmetry of @entity2 , symmetry of smile and composite score of SFGS. Objective measurement of facial structures with FACE system demonstrated an improvement of symmetry at rest and during smile through teeth @entity4 . At 18 months @entity0 displayed a good reinnervation with a further improvement of SFGS scores and @entity2 . No biting deficit has been observed. CONCLUSIONS: After V-VII @entity1 , at the first rehabilitative visit, @entity0 learn to activate the reinnervated facial muscles through teeth @entity4 . Eighteen months after the @entity1 , @entity0 display a further improvement of voluntary control on facial symmetry and smile and a @entity2 . CLINICAL REHABILITATION IMPACT: Our study illustrates the rehabilitative protocol after V-VII @entity1 and analyzes the clinical evolution after this intervention in terms of recovery of facial symmetry and @entity2 . This will be instrumental to standardize the rehabilitative protocol among different centers and to choose the best @entity0 -tailored surgical approach for subjects affected by @entity3 .

title: Rehabilitation and functional recovery after masseteric-facial nerve XXXX .

answer: @entity1


abstract: OBJECTIVE: To assess the BISAP and APACHE II scores in predicting severity according to the 2012 Atlanta classification and whether the @entity1 factor added to these scores improves prediction. MATERIAL AND METHODS: A prospective study between January 2013 and April 2014 including all @entity0 with @entity2 was performed according to the new Atlanta 2012 classification. ROC curves were fabricated for BISAP, BISAP-O, APACHE-II scores and Apache O and appropriate cutoffs were selected to the sensitivity, specificity, @entity4 , NPV, RPP and RPN. RESULTS: We studied 334 @entity0 . 65.27% were overweighted or @entity1 . The biliar etiology was 86.53%. Only 8.38% had severe @entity3 and 1.5% died. Areas under the ROC curve and cut points selected were: BISAP: 0.8725, 2; BISAP-O: 0.8246, 3; APACHE-II: 0.8547, 5; APACHE-O: 0.8531, 6. Using these cutoffs the sensitivity, specificity, @entity4 , NPV, RPP and RPN were BISAP: 60.71%, 91.83%, 40.48%, 96.23 %, 7.43, 0.43; BISAP-O: 60.71%, 86.93%, 29.82%, 96.03%, 4.76, 0.45; APACHE-II: 85.71%, 76.14%, 24.74%, 98.31%, 3.6, 0.19; APACHE-O: 82.14%, 79.41%, 26.74%, 97.98%, 4, 0.22. CONCLUSIONS: BISAP, BISAP-O, APACHE-II and APACHE-O systems can be used to identify @entity0 at low risk of severity because of its high NPV, however their use should be cautious considering that the RPP and RPN do not reach optimal levels indicating that their value in predicting severity is limited. On the other hand adding the @entity1 factor did not improve their predictive ability.

title: [BISAP-O y APACHE-O: utility in predicting severity in XXXX in modified Atlanta classification].

answer: @entity2


abstract: Mosquitoes are the most deadly vectors of parasites that cause diseases such as @entity2 , @entity10 , and @entity9 . In view of the recent increased interest in developing plant origin insecticides as an alternative to chemical insecticides, the objective of this study was to determine the repellent activity of creams formulated with @entity3 crude extract (MCE), @entity8 fraction (HF), and @entity4 fractions (EAFs) of Ocimum gratissimum and Lantana camara leaves in single and combined actions against female @entity7 . Evaluation was carried out in the net cages (30 by 30 by 30   cm) containing 60 blood-starved female mosquitoes each and were assayed in the @entity6 following World Health Organization 2009 protocol. All formulations (single and mixture) were applied at 2, 4, 6, and 8   mg/cm(2) in the exposed area of @entity0 hands. Only @entity5   +   white soft paraffin served as negative control and odomos (12% DEET) as positive control. All the formulations presented good protection against mosquito bites without any @entity1 by the @entity0 volunteers. The repellent activity was dependent on the strength of the extracts and fractions. Among the tested formulations, the maximum protection time was observed in MCE (120   min) and EAF (150   min) of O. gratissimum; MCE:MCE (150   min) and HF:HF (120   min) mixtures of both plants. In addition, MCE:MCE and HF:HF mixtures from both plants showed possible synergistic effect. From the results, the combination of O. gratissimum and L. camara to formulate natural mosquito repellent using small amount of extracts can be encouraging to be an alternative to conventional DEET.

title: Creams Formulated with Ocimum gratissimum L. and Lantana camara L. Crude Extracts and Fractions as Mosquito Repellents Against XXXX L. (Diptera: Culicidae).

answer: @entity7


abstract: The cohort of 17,200 female Swedish @entity4 @entity1 , who had been exposed to ionizing radiation because of @entity3 , was analyzed for @entity0 incidence with descriptive excess relative risk models and mechanistic models of @entity2 . The dosimetry system has recently been updated, leading to substantially reduced doses for the most highly exposed part of the Stockholm cohort. The follow-up includes @entity1 until December 2009 with 877 @entity0 cases. All models agree on the risk estimates. The excess relative and excess absolute risk at the age of 50 years are 0.48 Gy(-1) (95% CI 0.28; 0.69) and 10.4 (10(4)PYR Gy)(-1) (95% CI 6.1; 14.4) (95% CI 6.1; 14.4), respectively. These risk estimates are about a factor of 2 higher than previous analyses of this cohort as a consequence of the re-evaluation of the dosimetry system. Explicit models incorporating effects of genomic instability were developed and applied to the @entity4 cohort. It was found that a radiation-induced transition towards genomic instability was highly significant. The models indicate that the main effect of radiation-induced genomic instability is to increase the rate of transition of non-initiated cells to initiated cells with a proliferative advantage. The magnitude of such an acceleration cannot be inferred from epidemiological data alone, but must be complemented by radiobiological measurements.

title: XXXX risk and possible mechanisms of radiation-induced genomic instability in the Swedish @entity4 cohort after reanalyzed dosimetry.

answer: @entity0


abstract: The cohort of 17,200 female Swedish @entity4 @entity1 , who had been exposed to ionizing radiation because of @entity3 , was analyzed for @entity0 incidence with descriptive excess relative risk models and mechanistic models of @entity2 . The dosimetry system has recently been updated, leading to substantially reduced doses for the most highly exposed part of the Stockholm cohort. The follow-up includes @entity1 until December 2009 with 877 @entity0 cases. All models agree on the risk estimates. The excess relative and excess absolute risk at the age of 50 years are 0.48 Gy(-1) (95% CI 0.28; 0.69) and 10.4 (10(4)PYR Gy)(-1) (95% CI 6.1; 14.4) (95% CI 6.1; 14.4), respectively. These risk estimates are about a factor of 2 higher than previous analyses of this cohort as a consequence of the re-evaluation of the dosimetry system. Explicit models incorporating effects of genomic instability were developed and applied to the @entity4 cohort. It was found that a radiation-induced transition towards genomic instability was highly significant. The models indicate that the main effect of radiation-induced genomic instability is to increase the rate of transition of non-initiated cells to initiated cells with a proliferative advantage. The magnitude of such an acceleration cannot be inferred from epidemiological data alone, but must be complemented by radiobiological measurements.

title: @entity0 risk and possible mechanisms of radiation-induced genomic instability in the Swedish XXXX cohort after reanalyzed dosimetry.

answer: @entity4


abstract: UNASSIGNED: Bacterial cellulose (BC), a type of nanopolymer produced by @entity3 is a nanostructured material with unique properties and wide applicability. However, a standard medium used for the cultivation of BC, the Hestrin-Schramm medium, is expensive and prevents wide scale extension of BC applications. In this research, a relatively low-cost culture media was successfully developed from wood hot water extracts for the @entity3 23769 strain. Hot water extract (HWE) is a residual material originating from pulp mills and lignocellulosic biorefineries and consists of mainly monomeric @entity2 , organic acids and organics. The effects of different pH (5, 6, 7 and 8) and temperatures (26, 28 and 30  C) were also examined in this research. There were no significant differences in the crystallinity and the recorded Ia fraction of cellulose produced between Hestrin-Schramm and the HWE medium. The maximum production of 0.15g/l of BC was obtained at a pH of 8 and temperature of 28  C. @entity0 and xylose in the HWE were the main nutrient sources utilized in all BC cultivations based on high-pressure liquid chromatography (HPLC) results. HWE was shown to be a suitable @entity1 source for BC production, and a process was established for BC production from lignocellulosic feedstocks without using any modification of the HWE. HWE is an abundant and relatively inexpensive forest by-product. Using HWE for BC production could reduce burdens on the environment and also, achieve the goal of large scale BC production at low cost without using added culture nutrients.

title: Synthesis of bacterial cellulose using hot water extracted wood XXXX .

answer: @entity2


abstract: BACKGROUND: The management of @entity1 has become increasingly specialised. The care of @entity0 with @entity2 ( @entity2 ) has generally been part of core neurosurgical practice, provided by general neurosurgeons whatever their specialist interest. The aim of this present study therefore is to ascertain if, and to what extent care provided by a dedicated neurovascular team (compared to care provided by a general neurosurgical team) change @entity0 disposition in @entity2 . METHODS: This is a retrospective analysis of @entity2 @entity0 , identified from a departmental database of a single neurosurgical centre. In 2008, the service was reorganised such that a neurovascular team cared for all @entity2 @entity0 . We compared clinical outcome in @entity0 admitted prior to this service reorganisation (Period A, 2004-2007) with @entity0 admitted afterwards (Period B, 2009-2011). Survival and recovery were assessed according to the Glasgow Outcome Scale (GOS). Multi-factorial logistic regression analysis was performed to determine the injury and age adjusted incidence of complications, odds of survival at discharge, discharge home, mortality, good recovery (GOS 5) and favourable outcome, by dichotomising GOS (GOS 4-5 vs. GOS 1-3) at 3 months. RESULTS: 1114 @entity0 were included in the study. The mean age of @entity0 presenting in Period A (n=543) was younger [50 years (SD 13.5)] than those in Period B (n=571) [53 years (SD 13)]. @entity0 admitted in Period B were more likely to present as poor grade (World Federation of Neurological surgeons (WFNS) grades 4 and 5) compared to Period A (26.5% vs. 21.3%). No statistical differences between the groups in the incidence of pre-operative re-bleeding (3% vs. 5%) or rates of delayed @entity3 (16.1% vs. 16.1%) were observed. After adjustment for age, sex and injury severity, the odds of @entity0 time to discharge, discharge home and good recovery (GOS 5) were 27% (p<0.001), 45% (p=0.001) and 93% (p<0.001) higher respectively in Period B than Period A. CONCLUSIONS: The data presented here demonstrates that management of @entity2 by a dedicated neurovascular team improves the potential for @entity0 recovery.

title: Impact of specialist neurovascular care in XXXX .

answer: @entity2


abstract: BACKGROUND/PURPOSE: @entity3 ( @entity3 ) are rare congenital lung lesions often diagnosed by prenatal ultrasound. High-risk cases can result in @entity1 and prenatal or postnatal demise. Antenatal @entity4 has resulted in improved survival but it is unclear how to manage @entity0 who do not respond to a single course. METHODS: We present a bi-institutional retrospective review of @entity0 treated with multiple courses of prenatal @entity2 for high-risk @entity3 between 2007 and 2013. RESULTS: Nine @entity0 met inclusion criteria. All but one either had an increased CPAM volume ratio (CVR) or number of fluid-containing compartments involved after a single course of antenatal @entity4 , prompting additional courses. Four @entity0 stabilized, three improved and two progressed after the second course. The two cases with disease progression underwent an in utero resection. There were one in utero fetal demise and two deaths within the delivery room. Both fetuses that underwent a fetal resection died. All but one mother who delivered a viable fetus had complications of pregnancy. CONCLUSIONS: Multiple courses of antenatal @entity4 for high-risk fetal @entity3 often result in favorable short-term outcomes without the need for open fetal resection. Pregnancy complications are common and @entity0 within this cohort should be monitored closely.

title: Favorable outcomes in high-risk XXXX treated with multiple courses of maternal @entity4 .

answer: @entity3


abstract: BACKGROUND/PURPOSE: @entity3 ( @entity3 ) are rare congenital lung lesions often diagnosed by prenatal ultrasound. High-risk cases can result in @entity1 and prenatal or postnatal demise. Antenatal @entity4 has resulted in improved survival but it is unclear how to manage @entity0 who do not respond to a single course. METHODS: We present a bi-institutional retrospective review of @entity0 treated with multiple courses of prenatal @entity2 for high-risk @entity3 between 2007 and 2013. RESULTS: Nine @entity0 met inclusion criteria. All but one either had an increased CPAM volume ratio (CVR) or number of fluid-containing compartments involved after a single course of antenatal @entity4 , prompting additional courses. Four @entity0 stabilized, three improved and two progressed after the second course. The two cases with disease progression underwent an in utero resection. There were one in utero fetal demise and two deaths within the delivery room. Both fetuses that underwent a fetal resection died. All but one mother who delivered a viable fetus had complications of pregnancy. CONCLUSIONS: Multiple courses of antenatal @entity4 for high-risk fetal @entity3 often result in favorable short-term outcomes without the need for open fetal resection. Pregnancy complications are common and @entity0 within this cohort should be monitored closely.

title: Favorable outcomes in high-risk @entity3 treated with multiple courses of maternal XXXX .

answer: @entity4


abstract: BACKGROUND: @entity2 ( @entity2 ) is associated with a high risk of @entity3 events. We assessed the strategy of routine coronary angiography and subsequent coronary revascularization, if clinically indicated, in @entity0 with @entity2 who underwent percutaneous transluminal angioplasty (PTA). METHODS: Of a total 286 consecutive @entity2 @entity0 treated by PTA, 252 @entity0 who underwent coronary angiography before or after PTA were enrolled. @entity6 ( @entity6 ) was defined as angiographic stenosis >= 50% and significant @entity6 as >= 70% stenosis. RESULTS: Of the 252 @entity0 with @entity2 who underwent coronary angiography, a total of 167 @entity0 (66.3%) had @entity6 and 85 @entity0 (33.7%) did not have @entity6 . @entity0 in the @entity6 group were older, had a higher prevalence of @entity1 and @entity4 , and had a lower mean ejection fraction. In the @entity6 group, of the 145 @entity0 with significant @entity6 , percutaneous coronary intervention (PCI) was performed in 114 @entity0 (78.6%). At 1 year, the @entity6 and non- @entity6 groups had no statistically significant differences in mortality (7.1% vs 4.7%; P=.45), @entity7 (1.1% vs 0%; P=.31), and PCI (4.7% vs 1.1%; P=.31). These outcomes were similar after the adjustment of baseline confounders. At 1 year, the @entity6 and non- @entity6 groups had similar rates of repeat PTA (16.7% vs 17.6%; P=.86), @entity5 revascularization (13.7% vs 14.1%; P=.94), and amputation (19.1% vs 16.4%; P=.60). CONCLUSION: A strategy of routine coronary angiography and coronary revascularization may be a reasonable treatment option for these @entity0 who have high risk for severe @entity6 . A randomized trial is needed to determine if this is the preferred strategy for @entity2 @entity0 .

title: Clinical Outcomes of @entity0 With XXXX who Undergo Routine Coronary Angiography and Subsequent Percutaneous Coronary Intervention.

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) is associated with a high risk of @entity3 events. We assessed the strategy of routine coronary angiography and subsequent coronary revascularization, if clinically indicated, in @entity0 with @entity2 who underwent percutaneous transluminal angioplasty (PTA). METHODS: Of a total 286 consecutive @entity2 @entity0 treated by PTA, 252 @entity0 who underwent coronary angiography before or after PTA were enrolled. @entity6 ( @entity6 ) was defined as angiographic stenosis >= 50% and significant @entity6 as >= 70% stenosis. RESULTS: Of the 252 @entity0 with @entity2 who underwent coronary angiography, a total of 167 @entity0 (66.3%) had @entity6 and 85 @entity0 (33.7%) did not have @entity6 . @entity0 in the @entity6 group were older, had a higher prevalence of @entity1 and @entity4 , and had a lower mean ejection fraction. In the @entity6 group, of the 145 @entity0 with significant @entity6 , percutaneous coronary intervention (PCI) was performed in 114 @entity0 (78.6%). At 1 year, the @entity6 and non- @entity6 groups had no statistically significant differences in mortality (7.1% vs 4.7%; P=.45), @entity7 (1.1% vs 0%; P=.31), and PCI (4.7% vs 1.1%; P=.31). These outcomes were similar after the adjustment of baseline confounders. At 1 year, the @entity6 and non- @entity6 groups had similar rates of repeat PTA (16.7% vs 17.6%; P=.86), @entity5 revascularization (13.7% vs 14.1%; P=.94), and amputation (19.1% vs 16.4%; P=.60). CONCLUSION: A strategy of routine coronary angiography and coronary revascularization may be a reasonable treatment option for these @entity0 who have high risk for severe @entity6 . A randomized trial is needed to determine if this is the preferred strategy for @entity2 @entity0 .

title: Clinical Outcomes of XXXX With @entity2 who Undergo Routine Coronary Angiography and Subsequent Percutaneous Coronary Intervention.

answer: @entity0


abstract: PURPOSE: There is substantial variation across the National Breast and @entity1 Early Detection Program (NBCCEDP) grantees in terms of the proportion of the eligible population served by the grantees each year (hereafter referred to as the screening proportion). In this paper, we assess program- and state-level factors to better understand the reason for this variation in breast and cervical @entity1 screening proportions across the NBCCEDP grantees. METHODS: We constructed a longitudinal data set, consisting of data from NBCCEDP grantees for each of the three study years (program-years 2006-2007, 2008-2009, and 2009-2010). We performed multivariate analysis to explain the variation in breast and cervical @entity1 screening proportions across the grantees. The program-level factors studied were the total federal funds received, average cost of screening @entity0 by grantee, and the overall organizational structure. The state-level variables included were urban versus rural mix, access to care, and the size of the eligible population. RESULTS: Of the 48 grantees included in the study, those that serve larger populations, as measured by the size of the population and the percentage of @entity0 eligible for services, had lower screening proportions. Higher average cost of service delivery was also associated with lower screening proportions. In addition, grantees whose populations were more concentrated in urban areas had lower screening proportions. CONCLUSIONS: Overall, the average cost of screening, the overall size of the population eligible, and the concentration of population in urban areas all had a negative relationship to the proportion of eligible @entity0 screened by NBCCEDP grantees.

title: Explaining variation across grantees in breast and cervical XXXX screening proportions in the NBCCEDP.

answer: @entity1


abstract: BACKGROUND: Ipilimumab is an approved treatment for @entity0 with advanced @entity3 . We aimed to assess ipilimumab as adjuvant therapy for @entity0 with completely resected @entity9 at high risk of recurrence. METHODS: We did a double-blind, phase 3 trial in @entity0 with stage III @entity3 (excluding lymph node @entity1  <=1 mm or in-transit @entity1 ) with adequate resection of lymph nodes (ie, the primary @entity3 must have been completely excised with adequate surgical margins) who had not received previous systemic therapy for @entity3 from 91 hospitals located in 19 countries. @entity0 were randomly assigned (1:1), centrally by an interactive voice response system, to receive intravenous infusions of 10 mg/kg ipilimumab or placebo every 3 weeks for four doses, then every 3 months for up to 3 years. Using a minimisation technique, randomisation was stratified by disease stage and geographical region. The primary endpoint was recurrence-free survival, assessed by an independent review committee, and analysed by intention to treat. Enrollment is complete but the study is ongoing for follow-up for analysis of secondary endpoints. This trial is registered with EudraCT, number 2007-001974-10, and ClinicalTrials.gov, number NCT00636168. FINDINGS: Between July 10, 2008, and Aug 1, 2011, 951 @entity0 were randomly assigned to ipilimumab (n=475) or placebo (n=476), all of whom were included in the intention-to-treat analyses. At a median follow-up of 2  74 years (IQR 2  28-3  22), there were 528 recurrence-free survival events (234 in the ipilimumab group vs 294 in the placebo group). Median recurrence-free survival was 26  1 months (95% CI 19  3-39  3) in the ipilimumab group versus 17  1 months (95% CI 13  4-21  6) in the placebo group (hazard ratio 0  75; 95% CI 0  64-0  90; p=0  0013); 3-year recurrence-free survival was 46  5% (95% CI 41  5-51  3) in the ipilimumab group versus 34  8% (30  1-39  5) in the placebo group. The most common grade 3-4 immune-related adverse events in the ipilimumab group were gastrointestinal (75 [16%] vs four [<1%] in the placebo group), hepatic (50 [11%] vs one [<1%]), and endocrine (40 [8%] vs none). Adverse events led to discontinuation of treatment in 245 (52%) of 471 @entity0 who started ipilimumab (182 [39%] during the initial treatment period of four doses). Five @entity0 (1%) died due to drug-related adverse events. Five (1%) @entity0 died because of drug-related adverse events in the ipilimumab group; three @entity0 died because of @entity5 (two with @entity4 ), one @entity0 because of @entity6 , and one @entity0 because of @entity2 with @entity8 . INTERPRETATION: Adjuvant ipilimumab significantly improved recurrence-free survival for @entity0 with completely resected high-risk @entity9 . The adverse event profile was consistent with that observed in advanced @entity3 , but at higher incidences in particular for @entity7 . The risk-benefit ratio of adjuvant ipilimumab at this dose and schedule requires additional assessment based on distant @entity1 -free survival and overall survival endpoints to define its definitive value. FUNDING: Bristol-Myers Squibb.

title: Adjuvant ipilimumab versus placebo after complete resection of high-risk XXXX (EORTC 18071): a randomised, double-blind, phase 3 trial.

answer: @entity9


abstract: Seven hundred and seventy-two @entity0 suffering from @entity2 and upper stomach were seen by two surgeons at the Manchester Regional Cardiothoracic Centre over a 15-year period. Five hundred and thirty-one @entity0 had an operation, and of these, 449 had a resection. Throughout the period under review, the policy was to resect the primary @entity1 whenever possible. No emphasis was placed on extensive preoperative parenteral feeding. Adequate rather than radical resection was the aim of the surgery, but even if a curative operation was not possible, the primary was removed if at all possible. Gastric drainage in the immediate postoperative period by nasogastric tube or pyloroplasty was never used. A new classification of high or low @entity1 according to the level seen at oesophagoscopy is suggested; in 30 cases designated as "high", a planned resection was carried out using a bilateral thoracotomy, a method not previously described. The overall operative mortality was 9.2%. Of those having a resection it was 7.6%, and there were only three deaths in the last 120 resections. The predicted actuarial survival in this series of resections was 18% at five years and 12% at 10 years.

title: Surgical treatment of XXXX .

answer: @entity2


abstract: The @entity3 , and avian @entity7 , into Madin-Darby @entity0 kidney (MDCK) cells was examined both biochemically and morphologically. At low multiplicity and 0 degrees C, viruses bound to the cell surface but were not internalized. Binding was not greatly dependent on the pH of the medium and reached an equilibrium level in 60-90 min. Over 90% of the bound viruses were removed by neuraminidase but not by proteases. When cells with prebound virus were warmed to 37 degrees C, part of the virus became resistant to removal b neuraminidase, with a half-time of 10-15 min. After a brief lag period, degraded viral material was released into the medium. The neuraminidase-resistant virus was capable of infecting the cells and probably did so by an intracellular route, since @entity5 , a lysosomotropic agent, blocked both the @entity1 and the degradation of viral protein. When the entry process was observed by electron microscopy, viruses were seen bound primarily to microvilli on the cell surface at 0 degrees C and, after warming at 37 degrees C, were endocytosed in @entity2 , @entity6 , and large smooth-surfaced vacuoles. Viruses were also present in smooth-surfaced invaginations and small smooth-surfaced vesicles at both temperatures. At physiological pH, no fusion of the virus with the plasma membrane was observed. When prebound virus was incubated at a pH of 5.5 or below for 1 min at 37 degrees C, fusion was, however, detected by ferritin immunolabeling. t low multiplicity, 90% of the prebound virus became neuraminidase-resistant and was presumably fused after only 30 s at low pH. These experiments suggest that fowl plague virus enters MDCK cells by endocytosis in @entity2 and @entity6 and is transported to the lysosome where the low pH initiates a fusion reaction ultimately resulting in the transfer of the genome into the cytoplasm. The entry pathway of fowl plague virus thus resembles tht earlier described for @entity4 .

title: Infectious entry pathway of influenza virus in a XXXX kidney cell line.

answer: @entity0


abstract: BACKGROUND/AIMS: @entity1 ( @entity1 ) as assessed by transient elastography (TE) can change longitudinally in @entity0 with @entity2 ( @entity2 ). The aim of this study was to identify the factors that improve @entity1 . METHODS: Between April 2007 and December 2012, 151 @entity0 with @entity2 who underwent two TE procedures with an interval of about 2 years were enrolled. Ninety-six of the 151 @entity0 were treated with nucleos(t)ide analogues [the antiviral therapy (+) group], while the remaining 55 @entity0 were not [the antiviral therapy (-) group]. The two groups of @entity0 were stratified according to whether they exhibited an improvement or a deterioration in @entity1 during the study period (defined as an @entity1 change of  <=0 or >0 kPa, respectively, over a 1-year period), and their data were compared. RESULTS: No differences were observed between the antiviral therapy (+) and (-) groups with respect to either their clinical characteristics or their initial @entity1 . The observed @entity1 improvement was significantly greater in the antiviral therapy (+) group than in the antiviral therapy (-) group (-3.0 vs. 0.98 kPa, P=0.011). In the antiviral therapy (+) group, the initial @entity1 was higher in the @entity1 improvement group (n=63) than in the @entity1 deterioration group (n=33; 7.9 vs. 4.8 kPa, P<0.001). However, there were no differences in any other clinical characteristic. In the antiviral therapy (-) group, the initial @entity1 was also higher in the @entity1 improvement group (n=29) than in the @entity1 deterioration group (n=26; 8.3 vs. 6.5 kPa, P=0.021), with no differences in any other clinical characteristic. CONCLUSIONS: A higher initial @entity1 was the only factor associated with @entity1 improvement in @entity0 with @entity2 in this study.

title: The factors associated with longitudinal changes in liver stiffness in @entity0 with XXXX .

answer: @entity2


abstract: BACKGROUND/AIMS: @entity1 ( @entity1 ) as assessed by transient elastography (TE) can change longitudinally in @entity0 with @entity2 ( @entity2 ). The aim of this study was to identify the factors that improve @entity1 . METHODS: Between April 2007 and December 2012, 151 @entity0 with @entity2 who underwent two TE procedures with an interval of about 2 years were enrolled. Ninety-six of the 151 @entity0 were treated with nucleos(t)ide analogues [the antiviral therapy (+) group], while the remaining 55 @entity0 were not [the antiviral therapy (-) group]. The two groups of @entity0 were stratified according to whether they exhibited an improvement or a deterioration in @entity1 during the study period (defined as an @entity1 change of  <=0 or >0 kPa, respectively, over a 1-year period), and their data were compared. RESULTS: No differences were observed between the antiviral therapy (+) and (-) groups with respect to either their clinical characteristics or their initial @entity1 . The observed @entity1 improvement was significantly greater in the antiviral therapy (+) group than in the antiviral therapy (-) group (-3.0 vs. 0.98 kPa, P=0.011). In the antiviral therapy (+) group, the initial @entity1 was higher in the @entity1 improvement group (n=63) than in the @entity1 deterioration group (n=33; 7.9 vs. 4.8 kPa, P<0.001). However, there were no differences in any other clinical characteristic. In the antiviral therapy (-) group, the initial @entity1 was also higher in the @entity1 improvement group (n=29) than in the @entity1 deterioration group (n=26; 8.3 vs. 6.5 kPa, P=0.021), with no differences in any other clinical characteristic. CONCLUSIONS: A higher initial @entity1 was the only factor associated with @entity1 improvement in @entity0 with @entity2 in this study.

title: The factors associated with longitudinal changes in liver stiffness in XXXX with @entity2 .

answer: @entity0


abstract: INTRODUCTION: While @entity2 biopsy is recommended for @entity1 >= 1  mm in depth, its use among the elderly population is more controversial. We reviewed our experience at the University of Michigan with @entity1 @entity0 >= 75  years of age. METHODS: A total of 952 @entity1 @entity0 >= 75  years of age from 1996 to 2011 were identified from our institutional review board-approved database. In addition to clinicopathologic features and outcome data, comorbidity data were collected to calculate the Charlson comorbidity index (CCI). Univariate and multivariate Cox regression analysis was performed to characterize predictors of outcome. Kaplan-Meier analysis was used to generate survival curves. RESULTS: Among 553 clinically node-negative @entity0 with @entity1 >= 1  mm in Breslow thickness, 213 had wide excision alone, whereas 340 had excision and @entity2 biopsy, with 83 (24  %) having a positive @entity2 . @entity2 biopsy was less likely with older age (p  <  0.0001) and H_N location (p  =  0.007), but not CCI. @entity2 involvement was associated with female gender [odds ratio (OR) 2.15, p  =  0.009], Breslow thickness [OR 1.23/mm increase, p  =  0.004], and satellitosis (OR 4.43, p  =  0.004). Distant disease-specific survival was negatively associated with male gender (OR 1.5, p  =  0.007), increasing age (OR 1.05/year, p  <  0.001), increasing Breslow thickness (OR 1.07/year, p  =  0.013), ulceration (OR 1.51, p  =  0.004), a positive @entity2 (OR 2.61, p  <  0.001), and not having a @entity2 biopsy (OR 1.72, p  <  0.001). CCI did not predict worse disease-free or @entity1 -specific survival. CONCLUSIONS: WLE and @entity2 biopsy was not only strongly prognostic, but compared with WLE alone was associated with improved outcome, even after factoring for age and comorbidities. If otherwise healthy, @entity2 biopsy should be strongly considered for this population.

title: Sentinel Lymph Node Biopsy Use Among XXXX @entity0 75  Years of Age and Older.

answer: @entity1


abstract: INTRODUCTION: While @entity2 biopsy is recommended for @entity1 >= 1  mm in depth, its use among the elderly population is more controversial. We reviewed our experience at the University of Michigan with @entity1 @entity0 >= 75  years of age. METHODS: A total of 952 @entity1 @entity0 >= 75  years of age from 1996 to 2011 were identified from our institutional review board-approved database. In addition to clinicopathologic features and outcome data, comorbidity data were collected to calculate the Charlson comorbidity index (CCI). Univariate and multivariate Cox regression analysis was performed to characterize predictors of outcome. Kaplan-Meier analysis was used to generate survival curves. RESULTS: Among 553 clinically node-negative @entity0 with @entity1 >= 1  mm in Breslow thickness, 213 had wide excision alone, whereas 340 had excision and @entity2 biopsy, with 83 (24  %) having a positive @entity2 . @entity2 biopsy was less likely with older age (p  <  0.0001) and H_N location (p  =  0.007), but not CCI. @entity2 involvement was associated with female gender [odds ratio (OR) 2.15, p  =  0.009], Breslow thickness [OR 1.23/mm increase, p  =  0.004], and satellitosis (OR 4.43, p  =  0.004). Distant disease-specific survival was negatively associated with male gender (OR 1.5, p  =  0.007), increasing age (OR 1.05/year, p  <  0.001), increasing Breslow thickness (OR 1.07/year, p  =  0.013), ulceration (OR 1.51, p  =  0.004), a positive @entity2 (OR 2.61, p  <  0.001), and not having a @entity2 biopsy (OR 1.72, p  <  0.001). CCI did not predict worse disease-free or @entity1 -specific survival. CONCLUSIONS: WLE and @entity2 biopsy was not only strongly prognostic, but compared with WLE alone was associated with improved outcome, even after factoring for age and comorbidities. If otherwise healthy, @entity2 biopsy should be strongly considered for this population.

title: Sentinel Lymph Node Biopsy Use Among @entity1 XXXX 75  Years of Age and Older.

answer: @entity0


abstract: BACKGROUND: Previous reports showed lack of consensus concerning interruption of anticoagulant/antithrombotic (AC/ @entity5 ) treatment before @entity6 surgery. AIM: The aim of this study was to evaluate the risk of @entity2 in @entity0 on AC/ @entity5 treatment undergoing @entity6 surgery without interruption of this treatment. METHOD: This prospective cohort study included 271 consecutive @entity0 divided into two groups - @entity0 without and @entity0 with AC/ @entity5 therapy. Inclusion criteria were @entity6 ( @entity7 , @entity4 , or @entity3 ). Exclusion criteria were @entity0 undergoing regional lymph node dissection or sentinel lymph node biopsy. @entity2 complications taken into consideration were those evaluated as moderate or severe and requiring some form of surgical or non-surgical hemostasis on an outpatient or inpatient basis. RESULTS: There were 47 @entity0 in the AC/ @entity5 group and 224 in the control group (mean age = 76.6 and 68 years, respectively), with almost equal distribution of @entity1 in both groups. There were 34.1% of @entity0 on @entity5 , 55% on AC treatment, and 10.6% on mixed treatment (AC+ @entity5 or @entity5 + @entity5 ). @entity2 complications did not show a statistically significant difference between the two groups (p = 0.063). CONCLUSION: @entity6 surgery can be safely performed without discontinuation of AC/ @entity5 treatment, since the risk of @entity2 is statistically insignificant.

title: Evaluation of the risk of post-operative bleeding complications in XXXX surgery without interruption of anticoagulant/antithrombotic medication: A prospective cohort study.

answer: @entity6


abstract: PURPOSE: A new robotic surgery tool allows intraoperative ultrasound to be performed using a fully robotic technique. Herein, we evaluate the feasibility and reliability of robotically integrated ultrasound to guide resection of malignant @entity2 . MATERIAL AND METHODS: A consecutive series of ultrasound-guided robotic resections of primary and secondary @entity2 was analyzed in terms of perioperative data and specimen evaluation, focusing on the reliability of the new robot-integrated ultrasound probe. RESULTS: Ten consecutive @entity0 underwent 15 robotic liver resections. Two @entity0 were resected to excise primary @entity1 and eight underwent resections of liver metastases. R0 resections were achieved for all lesions. The median operative time was 247 min, and @entity3 was limited. No mortality occurred. CONCLUSIONS: Our present analysis confirmed the reliability of fully robotic liver resection guided via robotically integrated ultrasonic assessment. Robotic surgery, particularly hepatic resection, may benefit greatly from better manageability, and the fact that the surgeon can directly manage both the operative and the diagnostic parts of the procedure.

title: Robot-integrated intraoperative ultrasound: Initial experience with XXXX .

answer: @entity2


abstract: BACKGROUND/AIMS: This study aimed to determine the epidemiological characteristics of @entity3 in @entity7 . MATERIALS AND METHODS: In this multicenter, prospective, and cross-sectional registry study, data for 968 @entity0 with @entity3 from 21 centers in 7 geographic regions were analyzed. RESULTS: Diagnosis was @entity8 in 662 (68.4%) and @entity6 in 306 (31.6%) @entity0 . In total, 60.9% of @entity0 was male; mean age was 58.9  12.6 years. Among @entity0 , 15.0% was drinking @entity5 , 17.5% was smoking, 1.5% had familial history of @entity9 , 15.0% had @entity2 , 1.0% had @entity4 . Fruit and vegetable consumption was low (<3 times/week) in 35.5% and red meat consumption was high (>= 3 times/week) in 47.4% of the @entity0 . Median time-to diagnosis was 3.0 months and 4.0 months for @entity0 with @entity8 , respectively. Mean body mass index was >25 in all group of @entity0 . Distal rectum (61.3%) and sigmoid colon (36.8%) were the most common locations of @entity1 , for rectum and colon respectively. In total, 85.6% of @entity0 were operated; 25.8% had emergency surgery. Low anterior resection rate was 64.2% in @entity6 . In majority (89.8%) of the @entity0 with @entity6 who received preoperative treatment, conventional chemo-radiotherapy regimen was given. pTNM staging at diagnosis showed that stage III and IV @entity0 were in majority (35.9% and 29.7%, respectively). CONCLUSION: @entity8 is more frequent than @entity6 in @entity7 . @entity3 @entity0 are diagnosed at later stages. Most of the cases were operated. Interregional differences for risk factors are worthwhile for evaluation in future trials.

title: Epidemiology of @entity3 in XXXX : A cross-sectional disease registry study (A Turkish Oncology Group trial).

answer: @entity7


abstract: BACKGROUND/AIMS: This study aimed to determine the epidemiological characteristics of @entity3 in @entity7 . MATERIALS AND METHODS: In this multicenter, prospective, and cross-sectional registry study, data for 968 @entity0 with @entity3 from 21 centers in 7 geographic regions were analyzed. RESULTS: Diagnosis was @entity8 in 662 (68.4%) and @entity6 in 306 (31.6%) @entity0 . In total, 60.9% of @entity0 was male; mean age was 58.9  12.6 years. Among @entity0 , 15.0% was drinking @entity5 , 17.5% was smoking, 1.5% had familial history of @entity9 , 15.0% had @entity2 , 1.0% had @entity4 . Fruit and vegetable consumption was low (<3 times/week) in 35.5% and red meat consumption was high (>= 3 times/week) in 47.4% of the @entity0 . Median time-to diagnosis was 3.0 months and 4.0 months for @entity0 with @entity8 , respectively. Mean body mass index was >25 in all group of @entity0 . Distal rectum (61.3%) and sigmoid colon (36.8%) were the most common locations of @entity1 , for rectum and colon respectively. In total, 85.6% of @entity0 were operated; 25.8% had emergency surgery. Low anterior resection rate was 64.2% in @entity6 . In majority (89.8%) of the @entity0 with @entity6 who received preoperative treatment, conventional chemo-radiotherapy regimen was given. pTNM staging at diagnosis showed that stage III and IV @entity0 were in majority (35.9% and 29.7%, respectively). CONCLUSION: @entity8 is more frequent than @entity6 in @entity7 . @entity3 @entity0 are diagnosed at later stages. Most of the cases were operated. Interregional differences for risk factors are worthwhile for evaluation in future trials.

title: Epidemiology of XXXX in @entity7 : A cross-sectional disease registry study (A Turkish Oncology Group trial).

answer: @entity3


abstract: UNASSIGNED: The sensitivity and specificity of current @entity0 detection methods for foods are largely determined by the effectiveness of the elution, separation and concentration methods used. The aim of these methods is to produce a final suspension with an adequate concentration of @entity0 for detection, and a low concentration of interfering food debris. In the present study, a microfluidic device, which makes use of inertial separation, was designed and fabricated for the separation of @entity0 . A cyclical pumping platform and protocol was developed to concentrate 10 ml suspensions down to less than 1 ml. Tests involving @entity1 cysts and 1.90  m microbeads in pure suspensions demonstrated the specificity of the microfluidic chip for cysts over smaller non-specific particles. As the suspension cycled through the chip, a large number of beads were removed (70%) and the majority of the cysts were concentrated (82%). Subsequently, the microfluidic inertial separation chip was integrated into a method for the detection of @entity1 cysts from lettuce samples. The method greatly reduced the concentration of background debris in the final suspensions (10-fold reduction) in comparison to a conventional method. The method also recovered an average of 68.4% of cysts from 25 @entity2 samples, and had a limit of detection (LOD) of 38 cysts. While the recovery of cysts by inertial separation was slightly lower, and the LOD slightly higher, than the conventional method, the sample analysis time was greatly reduced as there were far fewer background food particles interfering with the detection of cysts by immunofluorescence microscopy.

title: Enhancing the detection of XXXX cysts in foods using inertial microfluidic separation.

answer: @entity1


abstract: BACKGROUND: In several studies, exposure to fine particulate matter (PM) has been associated with @entity1 , with inconsistent results. We used repeated measurements to examine the association of long-term fine and ultrafine particle exposure with several blood markers of @entity1 and coagulation. METHODS: We used baseline (2000-2003) and follow-up (2006-2008) data from the Heinz Nixdorf Recall Study, a German population-based prospective cohort of 4814 @entity0 . A chemistry transport model was applied to model daily surface concentrations of PM air pollutants (PM10, PM2.5) and particle number on a grid of 1   km(2). Applying mixed regression models, we analysed associations of long-term (mean of 365   days prior to blood draw) particle exposure at each @entity0 's residence with the level of high-sensitivity C reactive protein (hs-CRP), @entity4 , platelet and white cell count (WCC), adjusting for short-term PM exposure (moving averages of 1-7   days), personal characteristics, season, ambient temperature (1-5   days), @entity3 and time trend. RESULTS: We analysed 6488 observations: 3275 @entity0 with baseline data and 3213 with follow-up data. An increase of 2.4     g/m(3) in long-term PM2.5 was associated with an adjusted increase of 5.4% (95% CI 0.6% to 10.5%) in hs-CRP and of 2.3% (95% CI 1.4% to 3.3%) in the platelet count. @entity4 and WCC were not associated with long-term particle exposure. CONCLUSIONS: In this population-based cohort, we found associations of long-term exposure to PM with markers of @entity1 (hs-CRP) and coagulation (platelets). This finding supports the hypothesis that inflammatory processes might contribute to chronic effects of air pollution on @entity2 .

title: Long-term residential exposure to urban air pollution, and repeated measures of systemic blood markers of XXXX and coagulation.

answer: @entity1


abstract: OBJECTIVE: To determine whether acute @entity2 treatment outcome is different in @entity3 compared with @entity4 . METHODS: We examined pooled outcome data for sumatriptan treatment of @entity2 with and without aura from the sumatriptan/naratriptan aggregate @entity0 database. We also examined similar outcome data for inhaled dihydroergotamine (DHE) from a single, large randomized controlled study. RESULTS: The pooled @entity1 -free rates 2 hours postdose for sumatriptan 100 mg were significantly higher in @entity0 treating attacks without aura (32%) compared with the group who treated attacks with aura (24%) (p < 0.001). The relative risk for @entity1 freedom 2 hours postdose for attacks without aura was 1.33 (95% confidence interval: 1.16-1.54). The number needed to treat for 2 hours of @entity1 freedom was 4.4 for attacks without aura and 6.2 for attacks with aura. For the clinical trial of DHE, the 2-hour @entity1 -free rates did not differ between @entity0 treating attacks without aura (29.4%) compared with those who treated attacks with aura (27.2%; p = 0.65). The relative risk for @entity1 freedom 2 hours postdose for attacks without aura vs with aura was 1.08 (95% confidence interval: 0.77-1.53). The number needed to treat for 2 hours @entity1 free was 5.8 for attacks without aura and 5.0 for attacks with aura. CONCLUSION: This post hoc analysis of pooled data from multiple randomized trials indicates that sumatriptan is less effective as acute therapy for @entity2 attacks with aura compared with attacks without aura. In the single study of inhaled DHE, the treatment had similar efficacy for @entity2 attacks with and without aura. Different responses of @entity2 with vs without aura to acute therapies may provide insight into underlying @entity2 mechanisms and influence the choice of acute therapies for different types of @entity2 attacks.

title: Reduced efficacy of sumatriptan in XXXX .

answer: @entity4