abstract: Treatment of @entity1 with toxic doses of @entity6 ( @entity7 ) results in reduction in feed intake, body weight, serum @entity5 (T4) and @entity4 (T3) concentrations, resting heart rates, and body temperatures. Some of these effects resemble changes characteristic of @entity3 . Therefore the effects of @entity7 on functional thyroid status were examined to relate changes in thyroid status with signs of @entity7 @entity2 . In the present study, the dose-related effects of @entity7 on plasma thyroid hormone concentrations and a number of indices of thyroid status were investigated and compared with signs of @entity7 @entity2 . Young adult male @entity1 were given single intraperitoneal doses of @entity7 (20, 40, or 80 mg/kg), and subsequent changes were evaluated 7 days after dosing. Decreases in body weight and feed intake were used as measures of @entity7 @entity2 and ranged from minimal to severe. Plasma T4 concentrations and free thyroxine index were drastically reduced at all doses, and these changes were mimicked by pair feeding only at the high dose of @entity7 (80 mg/kg). Plasma T3 concentrations were not affected by @entity7 treatment, whereas pair feeding at the high-dose level (80 mg @entity7 /kg) resulted in a significant reduction (ca. 50% from unlimited-fed control) in T3. Although @entity7 caused a dose-dependent decrease in thyroid gland weight which was not completely paralleled by pair feeding, thyroid histology was unremarkable. @entity7 treatment resulted in a small decrease in basal metabolic rate (8% at 80 mg @entity7 /kg). A greater reduction (ca. 18%) in basal metabolic rate was observed in vehicle-treated controls pair-fed to @entity1 of the 80 mg @entity7 /kg dose group. Thermogenesis, as measured by @entity0 consumption and body core temperatures, was not greatly affected by @entity7 treatment, and these changes were paralleled by pair feeding. Reductions in plasma T4 concentration and free thyroxine index at a low dose of @entity7 (20 mg/kg) indicate that @entity7 -induced hypothyroxinemia can be dissociated from its overtly toxic effects (i.e., severe hypophagia and body weight loss) observed at higher doses. The results obtained here suggest that despite alterations in plasma thyroid hormone levels there is no consistent pattern of effects on functional thyroid status which could explain the overt @entity2 of @entity7 .

title: Effects of XXXX on thyroid status in @entity1 .

answer: @entity6


abstract: Treatment of @entity1 with toxic doses of @entity6 ( @entity7 ) results in reduction in feed intake, body weight, serum @entity5 (T4) and @entity4 (T3) concentrations, resting heart rates, and body temperatures. Some of these effects resemble changes characteristic of @entity3 . Therefore the effects of @entity7 on functional thyroid status were examined to relate changes in thyroid status with signs of @entity7 @entity2 . In the present study, the dose-related effects of @entity7 on plasma thyroid hormone concentrations and a number of indices of thyroid status were investigated and compared with signs of @entity7 @entity2 . Young adult male @entity1 were given single intraperitoneal doses of @entity7 (20, 40, or 80 mg/kg), and subsequent changes were evaluated 7 days after dosing. Decreases in body weight and feed intake were used as measures of @entity7 @entity2 and ranged from minimal to severe. Plasma T4 concentrations and free thyroxine index were drastically reduced at all doses, and these changes were mimicked by pair feeding only at the high dose of @entity7 (80 mg/kg). Plasma T3 concentrations were not affected by @entity7 treatment, whereas pair feeding at the high-dose level (80 mg @entity7 /kg) resulted in a significant reduction (ca. 50% from unlimited-fed control) in T3. Although @entity7 caused a dose-dependent decrease in thyroid gland weight which was not completely paralleled by pair feeding, thyroid histology was unremarkable. @entity7 treatment resulted in a small decrease in basal metabolic rate (8% at 80 mg @entity7 /kg). A greater reduction (ca. 18%) in basal metabolic rate was observed in vehicle-treated controls pair-fed to @entity1 of the 80 mg @entity7 /kg dose group. Thermogenesis, as measured by @entity0 consumption and body core temperatures, was not greatly affected by @entity7 treatment, and these changes were paralleled by pair feeding. Reductions in plasma T4 concentration and free thyroxine index at a low dose of @entity7 (20 mg/kg) indicate that @entity7 -induced hypothyroxinemia can be dissociated from its overtly toxic effects (i.e., severe hypophagia and body weight loss) observed at higher doses. The results obtained here suggest that despite alterations in plasma thyroid hormone levels there is no consistent pattern of effects on functional thyroid status which could explain the overt @entity2 of @entity7 .

title: Effects of @entity6 on thyroid status in XXXX .

answer: @entity1


abstract: Due to methodologic difficulties, few investigations have been made on the blood flow velocity in the cerebral microcirculation. Using a newly developed video camera method, we simultaneously measured the blood flow velocity and diameter of pial arteries during hemorrhagic @entity2 , after blood pressure recovery, and during @entity1 inhalation in @entity0 . When the mean arterial blood pressure was lowered from 129.7 +/- 6.6 to 71.5 +/- 4.1 mm Hg, the blood flow velocity inevitably decreased from 36.6 +/- 5.3 to 27.0 +/- 3.9 mm/sec (p less than 0.001). The calculated blood flow rate [pi X (diameter/2)2 X flow velocity] was preserved in cases with concomitant vasodilation. Conversely, the blood flow velocity increased from 25.3 +/- 5.1 to 31.0 +/- 5.4 mm/sec (p less than 0.001) after mean arterial blood pressure recovery from 67.1 +/- 3.7 to 129.8 +/- 5.8 mm Hg. The blood flow rate was again preserved in vessels with a vasoconstrictive response. Each pial artery apparently dilated or constricted in proportion to the decrease or increase in flow velocity during blood pressure changes, maintaining a constant cerebral blood flow. This indicated the importance of the pial arteries in the mechanisms of cerebral blood flow autoregulation. During 5% @entity1 inhalation, the blood flow velocity increased markedly from 25.4 +/- 4.6 to 37.2 +/- 10.0 mm/sec (p less than 0.05), while the pial artery diameter (85.0 +/- 13.7 microns) increased by 9.6 +/- 1.5% (p less than 0.01). The increased flow velocity might be attributable to preferential dilatation of small arterioles or intraparenchymal vessels during @entity3 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Quantitative measurement of blood flow velocity in feline pial arteries during hemorrhagic XXXX and @entity3 .

answer: @entity2


abstract: Due to methodologic difficulties, few investigations have been made on the blood flow velocity in the cerebral microcirculation. Using a newly developed video camera method, we simultaneously measured the blood flow velocity and diameter of pial arteries during hemorrhagic @entity2 , after blood pressure recovery, and during @entity1 inhalation in @entity0 . When the mean arterial blood pressure was lowered from 129.7 +/- 6.6 to 71.5 +/- 4.1 mm Hg, the blood flow velocity inevitably decreased from 36.6 +/- 5.3 to 27.0 +/- 3.9 mm/sec (p less than 0.001). The calculated blood flow rate [pi X (diameter/2)2 X flow velocity] was preserved in cases with concomitant vasodilation. Conversely, the blood flow velocity increased from 25.3 +/- 5.1 to 31.0 +/- 5.4 mm/sec (p less than 0.001) after mean arterial blood pressure recovery from 67.1 +/- 3.7 to 129.8 +/- 5.8 mm Hg. The blood flow rate was again preserved in vessels with a vasoconstrictive response. Each pial artery apparently dilated or constricted in proportion to the decrease or increase in flow velocity during blood pressure changes, maintaining a constant cerebral blood flow. This indicated the importance of the pial arteries in the mechanisms of cerebral blood flow autoregulation. During 5% @entity1 inhalation, the blood flow velocity increased markedly from 25.4 +/- 4.6 to 37.2 +/- 10.0 mm/sec (p less than 0.05), while the pial artery diameter (85.0 +/- 13.7 microns) increased by 9.6 +/- 1.5% (p less than 0.01). The increased flow velocity might be attributable to preferential dilatation of small arterioles or intraparenchymal vessels during @entity3 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Quantitative measurement of blood flow velocity in feline pial arteries during hemorrhagic @entity2 and XXXX .

answer: @entity3


abstract: BACKGROUND: We examined the hypothesis that the minimum alveolar concentration of @entity4 for maintaining bispectral index (BIS) below 50 (MACBIS 50 ) decreases with advance of age. METHODS: Sixty young (20-30 year), middle-aged (31-65 year) and elderly (66-80 year) @entity0 were included (n = 20, each group). Five minutes following the start of continuous intravenous administration of @entity2 at 0.25  g/kg/min, general anaesthesia was induced with @entity1 2 mg/kg and @entity3 0.8 mg/kg to facilitate tracheal intubation. Infusion of @entity2 was stopped immediately after tracheal intubation. When BIS began to increase > 60, maintenance of anaesthesia was started with an end-tidal @entity4 concentration of 4.0% and maintained for 10 min followed by 1-min assessment of BIS taken at 10-s intervals. MACBIS 50 of each age group was estimated by up-down methodology. RESULTS: MACBIS 50 of @entity4 in young, middle-aged and elderly @entity0 was 4.25% end-tidal (95% confidence intervals 4.04-4.46), 3.58% (3.38-3.79) and 2.75% (2.50-3.00) respectively. MACBIS 50 was higher (P = 0.011) in young @entity0 and lower (P = 0.012) in elderly @entity0 than those in middle-aged @entity0 . CONCLUSIONS: Advance in age significantly decreased the concentrations of @entity4 required to maintain BIS below 50. BIS reflected age-associated decrease in end-tidal concentrations of @entity4 required for maintaining adequate depth of anaesthesia during resting state.

title: Age-dependent decrease in XXXX concentration for maintaining bispectral index below 50.

answer: @entity4


abstract: BACKGROUND: The purpose of this study was to determine the one-year mortality rate and its predictors regarding long-term intensive care-treated @entity0 together with their health-related quality of life (HRQL), place of living, healthcare use and long-term complication characteristics after @entity1 ( @entity1 ) discharge. METHODS: A retrospective cohort study was performed in a 20-bed mixed @entity1 . The @entity0 that were treated for more than 72  h between 2007 and 2012 were included in this study. The one-year mortality rate was calculated, and the characteristics of the @entity1 survivors that died within one year after @entity1 discharge were further analysed. For all @entity0 , the Dutch version of the SF-36 questionnaire was used to assess their current HRQL. The results were compared with a normal population. Additionally, @entity0 were questioned about their place of living, and their general practitioners (GPs) were questioned about the @entity0 ' possible long-term complications. RESULTS: Seven hundred and forty @entity0 were included in this study, and their one-year mortality rate was 28  %, of which half died within the first week after @entity1 discharge. The one-year mortality rate predictors included age at the time of @entity1 admission, APACHE IV-predicted mortality score, number of comorbidities and @entity1 re-admissions. The @entity1 survivor HRQL was significantly lower compared with the normal population. Half of the @entity0 did not return to their pre-hospital place of living, and numerous possible long-term complications were reported, particularly decreased tolerance, chronic fatigue and processing problems of relatives. CONCLUSIONS: One-year mortality rate of long-term @entity1 -treated @entity0 was 28  %, and this was predicted by age, disease severity, comorbidities and @entity1 re-admissions. The @entity1 survivors reported a lower HRQL, and a minority of these @entity0 returned home directly after hospital discharge; however, GPs reported numerous possible long-term complications.

title: Long-term treated intensive care XXXX outcomes: the one-year mortality rate, quality of life, health care use and long-term complications as reported by general practitioners.

answer: @entity0


abstract: @entity3 is an inflammatory disease that results in the destruction of soft tissue and bone around the implant. @entity2 implant corrosion has been attributed to the implant failure and cytotoxic effects to the alveolar bone. We have documented the extent of @entity2 release into surrounding plaque in @entity0 with and without @entity3 . An in vitro model was designed to represent the actual environment of an implant in a @entity0 ' @entity4 . The model uses actual oral microbiota from a volunteer, allows monitoring electrochemical processes generated by biofilms growing on implants and permits control of biocorrosion electrical current. As determined by next generation DNA sequencing, microbial compositions in experiments with the in vitro model were comparable with the compositions found in @entity0 with implants. It was determined that the electrical conductivity of @entity2 implants was the key factor responsible for the biocorrosion process. The interruption of the biocorrosion current resulted in a 4-5 fold reduction of corrosion. We propose a new design of dental implant that combines @entity2 in zero oxidation state for osseointegration and strength, interlaid with a nonconductive ceramic. In addition, we propose electrotherapy for manipulation of microbial biofilms and to induce @entity1 in @entity3 @entity0 .

title: Interruption of Electrical Conductivity of XXXX Dental Implants Suggests a Path Towards Elimination Of Corrosion.

answer: @entity2


abstract: AIM: Sympathetic overdrive is generally the main pathophysiological abnormality in @entity1 . However, its grading is not easy in clinical practice because of its complex interactions and differences in phenotypical expression. We proposed an easy, feasible, and global scaling system for sympathetic activity level. 'Sympathetic activity index' (SAI) is based on scores of heart rate, BMI, and blood pressure categories, which are the major representatives of sympathetic activity. MATERIALS AND METHODS: Respectively, 1, 2, and 3 points were determined for heart rate below 69, 70-89, and above 90   bpm; -1, 1, and 2 points for BMI less than 20, 20-24.9, and at least 25   kg/m; and 1, 2, and 3 points for normal, @entity4 , and @entity2 categories. Demographic and echocardiographic parameters, and left ventricular (LV) mass and mass indexes (LVMIBSA and LVMIHeight) of 545 young males were compared among groups with @entity6 -8. RESULTS: We observed that @entity5 , LVMIBSA, and LVMIHeight, left atrial diameter were significantly increased in association with SAI (P<0.001). SAI was correlated with @entity5 (R=0.314, P<0.001), LVMIBSA (R=193, P<0.001), and LVMIHeight (R=0.316, P<0.001). SAI of at least 5.5 could determine the left @entity3 with a sensitivity and a specificity of 57 and 70%, respectively (AUC=682, 95% confidence interval 0.610-0.753, P<0.001). CONCLUSION: Integration of clinical, anthropometric, and hemodynamic variables in a novel index such as SAI may provide an objective and noninvasive means of grading actual sympathetic drive. SAI may be used to follow-up sympathetic activity and to predict clinical events in the management of young @entity0 with @entity1 .

title: Can a novel scoring system derived from hemodynamic and anthropometric variables predict sympathetic drive in young XXXX ?

answer: @entity0


abstract: The @entity2 virus causes @entity4 , leading to high morbidity and mortality in groups of @entity0 at higher risk. Antiviral drugs represent the first line of defense against @entity2 , both for @entity1 and pandemic outbreaks. Two main classes of drugs against @entity2 are in clinical use: M2-channel blockers and @entity3 inhibitors. Nevertheless, because @entity2 strains that are resistant to these antivirals have been described, the search for novel compounds with different mechanisms of action is necessary. Here, we investigated the anti- @entity2 activity of a fungi-derived natural product, @entity8 . This compound inhibited @entity2 A and @entity7 replication. This compound was more effective against @entity2 A(H3N2), with an EC50 of 100 nM. @entity8 cytoxicity was also very low, with a CC50 value of 1426  M. @entity8 inhibited @entity2 hemagglutination and, consequently, significantly impaired virus adsorption. Molecular modeling studies revealed that @entity8 docked in the @entity5 binding site of hemagglutinin, forming @entity6 bonds with highly conserved residues. Altogether, our results indicate that the chemical structure of @entity8 is promising for future anti- @entity2 drug design.

title: XXXX , a Fungi-Derived Tetrahydrofuran, Inhibits Influenza Replication by Targeting Its Surface Glycoprotein Hemagglutinin.

answer: @entity8


abstract: All @entity0 admitted from their own homes with a @entity2 to 12 hospitals in Stockholm County Council during a three-year period were reviewed six years after the @entity1 . The outcome of the @entity1 was related to different types of treatment centers (orthopedic and surgical) and primary treatments (conservative, internal fixation, and hemiarthroplasty [HAP]). The treatment results of the four most common types of internal fixation (von Bahr, Hessel/Nystr  m, Thornton, and Rydell nails), the experience of the surgeons, and the operative delay were also compared. Of 2418 @entity0 , the majority (93%) were treated with internal fixation. Thirty-three percent of @entity0 sustained complications after conservative treatment, 37% after primary internal fixation, and 15% after primary HAP. Early redisplacement of the @entity1 was most common when the Thornton nail was used and when less experienced surgeons treated the @entity1 . Early complications such as redisplacement and nonunion occurred most often in surgical departments, but the total frequency of complications including segmental collapse was equal for different treatment centers. In surgical departments these @entity1 were operatively treated most often by less experienced surgeons and the Thornton nail was used more frequently than in orthopedic departments. An operative delay of up to one week did not result in more complications. Seventy percent of the complications after primary treatment were reoperated. Only 11% were not reoperated, either because of the presence of only minor symptoms, or because of the @entity0 's poor general condition, which made reoperation too risky. The results of the present study stress the importance of stable fixation of this @entity1 and of the experience of the surgeon for optimal treatment results.

title: Treatment and outcome of XXXX . An analysis of 2418 @entity0 admitted from their own homes.

answer: @entity2


abstract: All @entity0 admitted from their own homes with a @entity2 to 12 hospitals in Stockholm County Council during a three-year period were reviewed six years after the @entity1 . The outcome of the @entity1 was related to different types of treatment centers (orthopedic and surgical) and primary treatments (conservative, internal fixation, and hemiarthroplasty [HAP]). The treatment results of the four most common types of internal fixation (von Bahr, Hessel/Nystr  m, Thornton, and Rydell nails), the experience of the surgeons, and the operative delay were also compared. Of 2418 @entity0 , the majority (93%) were treated with internal fixation. Thirty-three percent of @entity0 sustained complications after conservative treatment, 37% after primary internal fixation, and 15% after primary HAP. Early redisplacement of the @entity1 was most common when the Thornton nail was used and when less experienced surgeons treated the @entity1 . Early complications such as redisplacement and nonunion occurred most often in surgical departments, but the total frequency of complications including segmental collapse was equal for different treatment centers. In surgical departments these @entity1 were operatively treated most often by less experienced surgeons and the Thornton nail was used more frequently than in orthopedic departments. An operative delay of up to one week did not result in more complications. Seventy percent of the complications after primary treatment were reoperated. Only 11% were not reoperated, either because of the presence of only minor symptoms, or because of the @entity0 's poor general condition, which made reoperation too risky. The results of the present study stress the importance of stable fixation of this @entity1 and of the experience of the surgeon for optimal treatment results.

title: Treatment and outcome of @entity2 . An analysis of 2418 XXXX admitted from their own homes.

answer: @entity0


abstract: The frequent and severe @entity4 in ICU @entity0 suggest that these @entity0 are immunodeficient. We studied the phagocytic activity of granulocytes and monocytes isolated from the blood of 32 ICU @entity0 with @entity2 (19 male, 13 female; age @entity1 yr). Cells were tested in standard medium and in the presence of patients' serum. Blood granulocytes and monocytes were purified and separately exposed to opsonized zymosan (to test C3 receptor function), immunoglobulin-coated erythrocytes (to test Fc receptor function), and @entity5 -treated erythrocytes (to test nonspecific binding structures). Phagocytosis and @entity3 anion production were measured. Granulocytes of @entity0 exhibited a substantial decrease of zymosan ingestion (p less than .05), whereas phagocytosis of other particles was normal. Monocytes from the @entity0 displayed an unselective overall decrease of phagocytic ability for the three particle types (p less than .05). @entity0 ' sera were at least as efficient as a pool of normal sera in opsonizing zymosan. Further, no phagocytic inhibitor was found in the tested @entity0 . In conclusion, we point out a deficiency of membrane receptors of neutrophils and monocytes in ICU @entity0 with @entity4 .

title: Abnormalities of some phagocyte membrane receptors during XXXX .

answer: @entity4


abstract: A total of 250 consecutive admissions to an open-plan respiratory ICU were analyzed prospectively to identify the incidence of secondary hospital-acquired @entity3 and possible predisposing factors. Despite preventative measures and a restricted antibiotic policy, 23.6% of @entity0 developed secondary @entity3 . @entity0 admitted after multiple @entity1 were the only diagnostic category of @entity0 who showed a significantly increased incidence of secondary @entity3 . The length of hospitalization and number of @entity0 who had intubations or tracheostomies was higher in the group with @entity4 ; the causal relationship was difficult to establish. @entity0 who were not intubated or tracheostomized did not develop @entity4 . Prior administration of antibiotics did not appear to influence the incidence of @entity4 . There was a significant increase in secondary @entity3 in @entity0 with a higher therapeutic intervention scoring system score. The predominant pathogens cultured were highly resistant Gram-negative organisms, particularly Acinetobacter sp. and Pseudomonas sp. @entity6 was the most common Gram-positive pathogen. The ICU course was probably prolonged by the complication of @entity5 , which may have contributed to the @entity2 .

title: XXXX in a respiratory intensive care unit.

answer: @entity5


abstract: Peripheral arterial @entity7 and @entity6 of arterial grafts continue to threaten viability of extremities. Percutaneous @entity4 ( @entity4 ) and angiodilatation have afforded limb salvage in some of these @entity0 . Proper @entity0 selection appears to be the hallmark of success with @entity4 . During a recent three-year period, we used @entity4 in 32 extremities in 28 @entity0 who had acute @entity10 . Before @entity4 , 16 extremities were @entity2 at rest, and 16 had incapacitating @entity5 . The overall success rate was 38%, but some degree of thrombolysis occurred in 88%. Limb salvage was achieved in 27 of 32 extremities (84%). Only five of 17 limbs (29%) with arterial graft @entity6 required no operation or an operation of lesser magnitude than predicted before @entity4 . Of six extremities with native @entity8 , four (67%) were completely cleared with @entity4 . Major complications occurred in eight cases (25%), with two @entity4 -related @entity3 (6%). This study suggests that @entity4 is best reserved for individuals with @entity1 caused by @entity9 , those whose degree of @entity1 would tolerate a 24-hour trial of @entity4 , and those whose femoral or tibial runoff is not likely to require remedial operation.

title: Intra-arterial thrombolysis for XXXX : a three-year experience.

answer: @entity1


abstract: Body temperature was studied in 65 @entity0 admitted to hospital within four hours of the onset of symptoms of @entity1 . Thirty three @entity0 had been randomly assigned to intravenous @entity4 treatment and 32 to placebo treatment. @entity3 evolution was assessed by continuous vectorcardiography and @entity2 kinase release. Maximum and mean temperatures during the first eight days were significantly lower in the @entity4 group, who were discharged from hospital one day earlier. Eight @entity0 in the placebo group had temperatures of greater than 39 degrees compared with one in the @entity4 group. Both the mean temperature and the maximum temperature correlated significantly with indices of @entity3 size and ischaemic area as estimated by cumulative @entity2 kinase release, QRS vector difference, and ST vector magnitude. The results were consistent with the view that reduction of @entity3 size may partly explain the reduced pyrexial response after @entity4 treatment. Other mechanisms are probably also involved in larger @entity3 . Because high fever has detrimental haemodynamic effects in @entity1 , reduction of this response may be beneficial. The results support the early use of beta adrenoceptor blockade in @entity1 .

title: Fever after @entity1 in @entity0 treated with intravenous XXXX or placebo.

answer: @entity4


abstract: Body temperature was studied in 65 @entity0 admitted to hospital within four hours of the onset of symptoms of @entity1 . Thirty three @entity0 had been randomly assigned to intravenous @entity4 treatment and 32 to placebo treatment. @entity3 evolution was assessed by continuous vectorcardiography and @entity2 kinase release. Maximum and mean temperatures during the first eight days were significantly lower in the @entity4 group, who were discharged from hospital one day earlier. Eight @entity0 in the placebo group had temperatures of greater than 39 degrees compared with one in the @entity4 group. Both the mean temperature and the maximum temperature correlated significantly with indices of @entity3 size and ischaemic area as estimated by cumulative @entity2 kinase release, QRS vector difference, and ST vector magnitude. The results were consistent with the view that reduction of @entity3 size may partly explain the reduced pyrexial response after @entity4 treatment. Other mechanisms are probably also involved in larger @entity3 . Because high fever has detrimental haemodynamic effects in @entity1 , reduction of this response may be beneficial. The results support the early use of beta adrenoceptor blockade in @entity1 .

title: Fever after XXXX in @entity0 treated with intravenous @entity4 or placebo.

answer: @entity1


abstract: Body temperature was studied in 65 @entity0 admitted to hospital within four hours of the onset of symptoms of @entity1 . Thirty three @entity0 had been randomly assigned to intravenous @entity4 treatment and 32 to placebo treatment. @entity3 evolution was assessed by continuous vectorcardiography and @entity2 kinase release. Maximum and mean temperatures during the first eight days were significantly lower in the @entity4 group, who were discharged from hospital one day earlier. Eight @entity0 in the placebo group had temperatures of greater than 39 degrees compared with one in the @entity4 group. Both the mean temperature and the maximum temperature correlated significantly with indices of @entity3 size and ischaemic area as estimated by cumulative @entity2 kinase release, QRS vector difference, and ST vector magnitude. The results were consistent with the view that reduction of @entity3 size may partly explain the reduced pyrexial response after @entity4 treatment. Other mechanisms are probably also involved in larger @entity3 . Because high fever has detrimental haemodynamic effects in @entity1 , reduction of this response may be beneficial. The results support the early use of beta adrenoceptor blockade in @entity1 .

title: Fever after @entity1 in XXXX treated with intravenous @entity4 or placebo.

answer: @entity0


abstract: STUDY DESIGN: Quasi-experimental pre-post design with 6-month follow-up. OBJECTIVES: Active Living Leaders Training Program (ALLTP) equips individuals with knowledge and skills to encourage those with @entity1 ( @entity1 ) to increase their leisure-time physical activity (LTPA). The purpose of this pilot study was to, first, (i) evaluate @entity0 ' perceptions of the relevance/usefulness of ALLTP material/presentation, (ii) examine changes in @entity0 ' self-efficacy to promote LTPA, (iii) identify program components associated with greater self-efficacy and, second, measure @entity0 ' use of ALLTP skills and resources over the subsequent 6 months. SETTING: Canada. METHODS: Six @entity1 fitness trainers and six adults with @entity1 completed the three sections of ALLTP and, after each section, provided feedback. Six months later, @entity0 ' use of resources and skills was assessed. Means, standard deviations, repeated measures analysis of variance and Pearson's correlations were computed. RESULTS: Relevance/usefulness of the program was rated favorably. Self-efficacy to speak about and encourage LTPA remained high throughout the ALLTP and was positively correlated with the relevance/usefulness of program content and presentation. At follow-up, @entity0 had discussed LTPA with an average of seven @entity0 with disabilities and reported using at least one skill and resource from the ALLTP during those discussions. CONCLUSIONS: Users had positive perceptions of ALLTP and reported using the training to promote LTPA to others with disabilities. @entity0 feedback has been used to improve ALLTP. ALLTP can now be used to train @entity0 with @entity1 and @entity1 fitness trainers to promote LTPA to others with disabilities.

title: Active Living Leaders Training Program for adults with XXXX : a pilot study.

answer: @entity1


abstract: STUDY DESIGN: Review of clinical data. OBJECTIVES: The objective of this study was to describe the clinical and demographical profile of @entity0 with @entity2 ( @entity2 ) admitted to a single center. SETTING: Unidad de Medicina F  sica y Rehabilitaci  n Centro, M  xico.ParticipantsPatients with @entity2 attending rehabilitation for the first time.InterventionNot applicable.Main measurementsAge, gender, educational level, occupational activity, causes of injury, level of injury, neurological level, injury severity and category were recorded.ResultsFour hundred and sixty-four clinical files of @entity0 with @entity2 were collected. The mean age was 37.9  15.9 years; 78.2% (363/464) were male, basic educational level predominated in 63.6% (296/464) and 73.1% (339/464) were employed. A fall was the main mechanism of the injury in 41.6% (193/464), replacing automobile accidents from the first place. The mean age of @entity0 who suffered falls was 44  16 years. Injuries sustained by younger @entity0 were due to violence (28.4  10.1 years) and the cause of injury associated with male gender was violence. Thoracic level was most often affected (in 56.7%, 263/464) and neurological level C4 in 13.4% (62/464). In regard to the extent of the injury, lesions classified as American @entity3 Association A predominated (56.2%, 261/464) as with complete @entity1 in 43.3% (201/464).ConclusionsThe mean age of our @entity0 was 37 years. @entity0 are affected in a higher proportion. Our population has <9 years of study. Physical labor was the usual pre-injury activity. The main mechanism of injury was falls. Thoracic spine was the most affected.Spinal Cord advance online publication, 20 October 2015; doi:10.1038/sc.2015.164.

title: Clinical and demographic profile of XXXX : a mexican hospital-based study.

answer: @entity2


abstract: UNASSIGNED: Historically, the standard approach for all mitral valve surgery has been the mediasternotomy. Although initially developed for cosmesis, minimally invasive techniques for mitral valve surgery use a limited right anterior thoracotomy with and without endoscopic techniques, which have resulted in outcomes comparable to the traditional mediasternotomy incision(1,2). Advances in robotic technology, including three dimensional visualization and improved dexterity have facilitated the introduction of robotic surgery for mitral valve repairs. In an FDA safety and efficacy trial in 2000 involving 20 @entity0 , Nifong and co-workers used robotic technology to perform a wide spectrum of mitral valve repair procedures(3). Although crossclamp and operative times were longer when compared to the conventional mediasternotomy approach, the morbidity and mortality was similar and the mean hospital length of stay (LOS) was only 4 days. A follow-up study involving 112 @entity0 showed a 30-day mortality of 0.7% and no conversions to a mediasternotomy(4). The mean hospital LOS was 5 days and the 5-year freedom from reoperation was 90%. More recent series using robotic techniques for mitral valve repairs have duplicated these excellent outcomes(5,6). Although crossclamp, cardiopulmonary bypass, and total operative times are significantly longer, there are no differences in morbidity or mortality between robotic and non-robotic repairs. In general, robotic @entity0 spend one less day in the hospital. Follow-up from 1-3 years show that > 90% of @entity0 are free of moderate-to-severe @entity1 ( @entity1 ) and the need for another mitral valve procedure. However, despite the apparent cost savings of spending one less day in the hospital, Kam and co-workers could not demonstrate any differences in hospital expenses for @entity0 undergoing robotic mitral repairs(7). The decreased LOS appears to be offset by increased operation time. Furthermore, the cost of purchasing the robotic equipment, its maintenance and need for upgrades and supplies are usually not factored into most cost analyses.

title: Robotic Mitral Valve Repair for XXXX : Is it for Everyone?

answer: @entity1


abstract: UNASSIGNED: Recent consortium guidelines support research-based screening for those at high risk of @entity1 ( @entity2 ( @entity2 )). Genetic testing plays an important role in the establishment of high-risk @entity2 research clinics by delineating those individuals who would benefit from screening protocols. We retrospectively examined @entity0 referred for @entity2 -related genetic testing from January 2009 to June 2014. @entity0 were referred for a personal and/or family history of @entity2 or a questioned diagnosis of @entity4 ( @entity4 ). Of the 75 referred @entity0 , 36 underwent testing, of which 11 (31%) were mutation-positive. In total, 36% of @entity0 with @entity3 carried a mutation, 11% of @entity0 with a family history of @entity2 carried a mutation, and 20% of @entity0 with a personal history of @entity2 carried a mutation. The most common barrier to testing was lack of insurance coverage. Genetic testing yields a suitable number of mutation-positive individuals who may benefit from increased screening. Subjects with possible @entity4 yielded the highest positive rate. Individuals with @entity1 , onset of @entity1 before the age of 30 years, and those with a family history of @entity2 should be considered for testing. Sub-optimal insurance coverage remains a major deterrent to obtaining testing.

title: Identification of genetic risk for XXXX .

answer: @entity1


abstract: OBJECTIVES: The study sought to examine the relative importance of lesion location versus vessel area and plaque burden in predicting @entity1 within nonculprit @entity4 ( @entity4 ) in @entity0 with @entity3 . BACKGROUND: Previous studies have demonstrated that @entity1 is associated with larger vessel area and greater plaque burden clustering in the proximal segments of coronary arteries. METHODS: In the PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) study 3-vessel grayscale and radiofrequency-intravascular ultrasound was performed after successful percutaneous coronary intervention in 697 @entity0 with @entity3 . Untreated nonculprit lesion @entity4 were classified as proximal (<20  mm), mid (20 to 40 mm), and distal (>40 mm) according to the distance from the ostium to the maximum necrotic core  site. RESULTS: Overall, 74 ruptured @entity4 and 2,396 nonruptured @entity4 were identified in nonculprit vessels. The majority of @entity4 (73.6%) were located within 40 mm of the ostium, and the vessel area and plaque burden progressively decreased from proximal to distal FA location (both p  < 0.001). In a multivariate logistic regression model, independent predictors for  @entity1 included the distance from the ostium to the maximum necrotic core site per millimeter (odds ratio [OR]: 0.86; 95%  confidence interval [CI]: 0.76 to 0.98; p  = 0.02), plaque burden per 10% (OR: 2.05; 95% CI: 1.63 to  2.58; p  <  0.0001), vessel area per mm(2) (OR: 1.14; 95% CI: 1.11 to 1.17; p  < 0.0001), @entity2 (OR: 0.09; 95% CI: 0.05 to 0.18; p  <  0.0001), and  right coronary artery location (OR: 2.16; 95% CI: 1.25 to 3.27; p  = 0.006). By receiver-operating characteristic analysis, vessel area correlated with @entity1 stronger than either plaque burden (p  <  0.001) or location (p  < 0.001). CONCLUSIONS: Large vessel area, plaque burden, proximal location, right coronary artery location, and lack of @entity2 were associated with @entity1 . The present study suggests that among these variables, vessel area may be the strongest predictor of @entity1 among non-left main coronary arteries. ( PROSPECT: An Imaging Study in @entity0 With Unstable Atherosclerotic Lesions [PROSPECT]; NCT00180466).

title: Predictors of Plaque Rupture Within Nonculprit XXXX in @entity0 With Acute Coronary Syndromes: The PROSPECT Study.

answer: @entity4


abstract: OBJECTIVES: The study sought to examine the relative importance of lesion location versus vessel area and plaque burden in predicting @entity1 within nonculprit @entity4 ( @entity4 ) in @entity0 with @entity3 . BACKGROUND: Previous studies have demonstrated that @entity1 is associated with larger vessel area and greater plaque burden clustering in the proximal segments of coronary arteries. METHODS: In the PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) study 3-vessel grayscale and radiofrequency-intravascular ultrasound was performed after successful percutaneous coronary intervention in 697 @entity0 with @entity3 . Untreated nonculprit lesion @entity4 were classified as proximal (<20  mm), mid (20 to 40 mm), and distal (>40 mm) according to the distance from the ostium to the maximum necrotic core  site. RESULTS: Overall, 74 ruptured @entity4 and 2,396 nonruptured @entity4 were identified in nonculprit vessels. The majority of @entity4 (73.6%) were located within 40 mm of the ostium, and the vessel area and plaque burden progressively decreased from proximal to distal FA location (both p  < 0.001). In a multivariate logistic regression model, independent predictors for  @entity1 included the distance from the ostium to the maximum necrotic core site per millimeter (odds ratio [OR]: 0.86; 95%  confidence interval [CI]: 0.76 to 0.98; p  = 0.02), plaque burden per 10% (OR: 2.05; 95% CI: 1.63 to  2.58; p  <  0.0001), vessel area per mm(2) (OR: 1.14; 95% CI: 1.11 to 1.17; p  < 0.0001), @entity2 (OR: 0.09; 95% CI: 0.05 to 0.18; p  <  0.0001), and  right coronary artery location (OR: 2.16; 95% CI: 1.25 to 3.27; p  = 0.006). By receiver-operating characteristic analysis, vessel area correlated with @entity1 stronger than either plaque burden (p  <  0.001) or location (p  < 0.001). CONCLUSIONS: Large vessel area, plaque burden, proximal location, right coronary artery location, and lack of @entity2 were associated with @entity1 . The present study suggests that among these variables, vessel area may be the strongest predictor of @entity1 among non-left main coronary arteries. ( PROSPECT: An Imaging Study in @entity0 With Unstable Atherosclerotic Lesions [PROSPECT]; NCT00180466).

title: Predictors of Plaque Rupture Within Nonculprit @entity4 in XXXX With Acute Coronary Syndromes: The PROSPECT Study.

answer: @entity0


abstract: @entity8 is an @entity7 derivative which possesses a broad spectrum antimycotic activity, including activity against @entity5 . Its therapeutic activity and tolerability have been evaluated, in a double-blind clinical trial versus @entity4 , in 54 @entity0 affected by mycologically confirmed symptomatic @entity3 . Both drugs were administered intravaginally as a cream once a day for 7 days. Assessment was by laboratory mycological investigations and symptomatic evaluation. @entity0 'cured' at the end of the trial were re-evaluated after 4-6 weeks for possible relapses. Both treatments resulted in a progressive, statistically significant @entity2 (itching and discharge) and in elimination of Candida in more than 95% of @entity0 . When 'cured' @entity0 were reassessed 4-6 weeks after therapy, relapses occurred in four @entity0 after @entity8 treatment, but in none following @entity4 treatment. This apparent difference between treatments is far from being statistically significant and, therefore, may have been a chance occurrence. It should also be noted that @entity0 from the @entity8 group had a previous history of significantly more frequent episodes of @entity6 suggesting that they may have been at greater risk of re-infection than @entity0 from the control group. The tolerance of both treatments was excellent since no local or systemic signs or symptoms of @entity1 were reported. An equally high efficacy and safety for both drugs in the elimination of symptoms and objective evidence of @entity3 is indicated.

title: Effect of @entity8 in @entity3 : a double-blind clinical trial versus XXXX .

answer: @entity4


abstract: @entity8 is an @entity7 derivative which possesses a broad spectrum antimycotic activity, including activity against @entity5 . Its therapeutic activity and tolerability have been evaluated, in a double-blind clinical trial versus @entity4 , in 54 @entity0 affected by mycologically confirmed symptomatic @entity3 . Both drugs were administered intravaginally as a cream once a day for 7 days. Assessment was by laboratory mycological investigations and symptomatic evaluation. @entity0 'cured' at the end of the trial were re-evaluated after 4-6 weeks for possible relapses. Both treatments resulted in a progressive, statistically significant @entity2 (itching and discharge) and in elimination of Candida in more than 95% of @entity0 . When 'cured' @entity0 were reassessed 4-6 weeks after therapy, relapses occurred in four @entity0 after @entity8 treatment, but in none following @entity4 treatment. This apparent difference between treatments is far from being statistically significant and, therefore, may have been a chance occurrence. It should also be noted that @entity0 from the @entity8 group had a previous history of significantly more frequent episodes of @entity6 suggesting that they may have been at greater risk of re-infection than @entity0 from the control group. The tolerance of both treatments was excellent since no local or systemic signs or symptoms of @entity1 were reported. An equally high efficacy and safety for both drugs in the elimination of symptoms and objective evidence of @entity3 is indicated.

title: Effect of @entity8 in XXXX : a double-blind clinical trial versus @entity4 .

answer: @entity3


abstract: @entity8 is an @entity7 derivative which possesses a broad spectrum antimycotic activity, including activity against @entity5 . Its therapeutic activity and tolerability have been evaluated, in a double-blind clinical trial versus @entity4 , in 54 @entity0 affected by mycologically confirmed symptomatic @entity3 . Both drugs were administered intravaginally as a cream once a day for 7 days. Assessment was by laboratory mycological investigations and symptomatic evaluation. @entity0 'cured' at the end of the trial were re-evaluated after 4-6 weeks for possible relapses. Both treatments resulted in a progressive, statistically significant @entity2 (itching and discharge) and in elimination of Candida in more than 95% of @entity0 . When 'cured' @entity0 were reassessed 4-6 weeks after therapy, relapses occurred in four @entity0 after @entity8 treatment, but in none following @entity4 treatment. This apparent difference between treatments is far from being statistically significant and, therefore, may have been a chance occurrence. It should also be noted that @entity0 from the @entity8 group had a previous history of significantly more frequent episodes of @entity6 suggesting that they may have been at greater risk of re-infection than @entity0 from the control group. The tolerance of both treatments was excellent since no local or systemic signs or symptoms of @entity1 were reported. An equally high efficacy and safety for both drugs in the elimination of symptoms and objective evidence of @entity3 is indicated.

title: Effect of XXXX in @entity3 : a double-blind clinical trial versus @entity4 .

answer: @entity8


abstract: Between 1979 and 1985 a total of 8641 @entity0 were born at the gynecological clinic in Winterthur, 388 of them (4.5%) from breech presentation. All of these were evaluated with regard to external version, and conditions for an attempt at version were satisfied in 97 cases. The principal prerequisite was a gestational age of at least 37 weeks. External version was accomplished in 39 of the 97 cases (40.2%). Complications encountered were drops in fetal heart tone or @entity2 in 26 cases (26.8%); the attempt at version was abandoned for this reason in 22 cases. In one case premature detachment of the normally implanted placenta occurred 6 days after successful external version, and in one case an emergency cesarean section had to be performed owing to persistent @entity2 . In a further case @entity3 was established 18 hours after successful version on the basis of an absence of fetal movement, though no cause of @entity1 could be found. Among the 39 cases in which version was successful a cesarean section was only necessary in one (2.5%), as opposed to 21 in the 58 cases (36.2%) in which the attempt at version failed. Neonatal fetal condition (Apgar score and umbilical blood gas analysis) revealed that neonates born from vertex presentation are subject to very considerably less stress. The international literature is discussed and compared. It is found that there has been a change of trend from a tendency to reject external version in the 1970s to a majority favoring it in the 1980s.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [External version of breech presentation--a possibility for lowering the rate of cesarean section and XXXX morbidity].

answer: @entity0


abstract: Multipotent mesenchymal stem cells (MSCs) are recently found to alter the @entity2 condition. However their exact role in @entity2 development is not yet fully unraveled. MSCs were established to perform many of their actions through paracrine effect. Thus investigation of MSC secretome interaction with @entity2 cells may provide important information for scientists who are attempting to apply stem cells in the treatment of the disease. In this study we investigated the effect of @entity0 Wharton's jelly derived MSC (WJ-MSCs) secretome on proliferation, apoptotic potential of A549 @entity1 cells, and their response to the chemotherapeutic agent @entity3 . WJ-MSCs were isolated from @entity0 umbilical cord and then characterized according to the International Society for Cellular Therapy criteria and WJ-MSC secretome was collected. @entity5 cell proliferation assay and @entity6 -PI staining were used for the evaluation of cytotoxic and proapoptotic effects of WJ-MSC secretome on A549 cells. WJ-MSC secretome neither induced @entity1 cells nor affected the apoptotic potential of the @entity2 cells. We also studied the combinatorial effect of WJ-MSC secretome and the anticancer drug doxorubicinwhich showed no induction of drug resistance when A549 cells was treated with combination of WJ-MSC secretome and @entity3 . Although MSCs did not show antitumor properties, our in vitro results showed that MSC secretome was not tumorigenic and also did not make @entity1 cells resistant to @entity3 . Thus MSC secretome could be considered safe for other medical purposes such as cardiovascular, neurodegenerative, and @entity4 which may exist or occur in @entity2 @entity0 .

title: Effect of @entity0 Wharton's jelly mesenchymal stem cell secretome on proliferation, apoptosis and drug resistance of XXXX cells.

answer: @entity1


abstract: Multipotent mesenchymal stem cells (MSCs) are recently found to alter the @entity2 condition. However their exact role in @entity2 development is not yet fully unraveled. MSCs were established to perform many of their actions through paracrine effect. Thus investigation of MSC secretome interaction with @entity2 cells may provide important information for scientists who are attempting to apply stem cells in the treatment of the disease. In this study we investigated the effect of @entity0 Wharton's jelly derived MSC (WJ-MSCs) secretome on proliferation, apoptotic potential of A549 @entity1 cells, and their response to the chemotherapeutic agent @entity3 . WJ-MSCs were isolated from @entity0 umbilical cord and then characterized according to the International Society for Cellular Therapy criteria and WJ-MSC secretome was collected. @entity5 cell proliferation assay and @entity6 -PI staining were used for the evaluation of cytotoxic and proapoptotic effects of WJ-MSC secretome on A549 cells. WJ-MSC secretome neither induced @entity1 cells nor affected the apoptotic potential of the @entity2 cells. We also studied the combinatorial effect of WJ-MSC secretome and the anticancer drug doxorubicinwhich showed no induction of drug resistance when A549 cells was treated with combination of WJ-MSC secretome and @entity3 . Although MSCs did not show antitumor properties, our in vitro results showed that MSC secretome was not tumorigenic and also did not make @entity1 cells resistant to @entity3 . Thus MSC secretome could be considered safe for other medical purposes such as cardiovascular, neurodegenerative, and @entity4 which may exist or occur in @entity2 @entity0 .

title: Effect of XXXX Wharton's jelly mesenchymal stem cell secretome on proliferation, apoptosis and drug resistance of @entity1 cells.

answer: @entity0


abstract: AIM: To examine the usefulness of a new tapered @entity5 ( @entity5 ) in @entity0 with unresectable malignant hilar @entity4 . METHODS: This new tapered @entity5 was placed in 11 @entity0 with Bismuth II or severer unresectable malignant hilar @entity4 , as a prospective study. The subjects were six @entity0 with @entity3 , three with @entity2 , and two with metastatic @entity4 . @entity1 morphology was Bismuth II: 7, IIIa: 3, and IV: 1. UMIN Clinical Trial Registry (UMIN000004758). RESULTS: @entity5 placement was 100% (11/11) successful. There were no procedural accidents. The mean patency period was 208.401 d, the median survival period was 142.000 d, and the mean survival period was 193.273 d. Occlusion rate was 36.4% (4/11); the causes of occlusion were ingrowth and overgrowth in 2 @entity0 each, 18.2%, respectively. @entity0 with occlusion underwent endoscopic treatment one more time and all were treatable. CONCLUSION: The tapered @entity5 proved useful in @entity0 with unresectable malignant hilar @entity4 because it provided a long patency period, enabled re-treatment by re-intervention, and no procedural accidents occurred.

title: New tapered @entity5 for unresectable malignant hilar XXXX .

answer: @entity4


abstract: AIM: To examine the usefulness of a new tapered @entity5 ( @entity5 ) in @entity0 with unresectable malignant hilar @entity4 . METHODS: This new tapered @entity5 was placed in 11 @entity0 with Bismuth II or severer unresectable malignant hilar @entity4 , as a prospective study. The subjects were six @entity0 with @entity3 , three with @entity2 , and two with metastatic @entity4 . @entity1 morphology was Bismuth II: 7, IIIa: 3, and IV: 1. UMIN Clinical Trial Registry (UMIN000004758). RESULTS: @entity5 placement was 100% (11/11) successful. There were no procedural accidents. The mean patency period was 208.401 d, the median survival period was 142.000 d, and the mean survival period was 193.273 d. Occlusion rate was 36.4% (4/11); the causes of occlusion were ingrowth and overgrowth in 2 @entity0 each, 18.2%, respectively. @entity0 with occlusion underwent endoscopic treatment one more time and all were treatable. CONCLUSION: The tapered @entity5 proved useful in @entity0 with unresectable malignant hilar @entity4 because it provided a long patency period, enabled re-treatment by re-intervention, and no procedural accidents occurred.

title: New tapered XXXX for unresectable malignant hilar @entity4 .

answer: @entity5


abstract: BACKGROUND: The standard approach to vascular @entity1 involves arterial exposure and reconstruction using either a vein or @entity4 graft. We have developed a novel technique to repairing @entity5 by deploying commercially available vascular stents through an open approach, thus eliminating the need for suture @entity2 . The objective of this study was to evaluate the feasibility, stent deployment time (SDT), and stent patency of this technique in a ewe @entity5 model. METHODS: After proximal and distal control, a 2-cm superficial femoral arterial segment was resected in 8 Dorper ewes to simulate an @entity5 . Two stay sutures were placed in the 3- and 9-o'clock positions of the transected arterial ends to prevent further retraction. Ten milliliters of 10-IU/mL heparinized saline was flushed proximally and distally. An arteriotomy was then created 2.5 cm from the transected distal end through which we deployed Gore Viabahn stents with a 20% oversize and at least 1-cm overlap with the native vessel on either end. The arteriotomy was then closed with 3 (1) interrupted 6-0 Prolene sutures. The ewes were fed @entity0 325 mg daily. Duplex was performed at 2 months postoperatively to evaluate stent patency. SDT was defined as time from stay suture placement to arteriotomy closure. RESULTS: The 8 ewes weighed a mean (SD) of 34.4 (4.3) kg. The mean (SD) superficial femoral arterial was 4.3 (0.6) mm. @entity6 mm * 5 cm and two 6 mm * 5 cm Gore Viabahn stents were deployed. The mean (SD) SDT was 34 (19) minutes, with a trend toward less time with increasing experience (SDTmax, 60 minutes; SDTmin, 10 minutes). Duplex performed at 2 months postoperatively showed stent patency in five of eight stents. There was an association between increasing SDT and stent @entity3 . CONCLUSION: Open deployment of commercially available vascular stents to treat @entity5 is a conceptually sound and technically feasible alternative to standard open repair. Larger studies are needed to refine this technique and minimize stent complications, which are likely technical in nature.

title: The elimination of XXXX in open @entity1 vascular reconstruction: A novel technique using an animal model.

answer: @entity2


abstract: BACKGROUND: The standard approach to vascular @entity1 involves arterial exposure and reconstruction using either a vein or @entity4 graft. We have developed a novel technique to repairing @entity5 by deploying commercially available vascular stents through an open approach, thus eliminating the need for suture @entity2 . The objective of this study was to evaluate the feasibility, stent deployment time (SDT), and stent patency of this technique in a ewe @entity5 model. METHODS: After proximal and distal control, a 2-cm superficial femoral arterial segment was resected in 8 Dorper ewes to simulate an @entity5 . Two stay sutures were placed in the 3- and 9-o'clock positions of the transected arterial ends to prevent further retraction. Ten milliliters of 10-IU/mL heparinized saline was flushed proximally and distally. An arteriotomy was then created 2.5 cm from the transected distal end through which we deployed Gore Viabahn stents with a 20% oversize and at least 1-cm overlap with the native vessel on either end. The arteriotomy was then closed with 3 (1) interrupted 6-0 Prolene sutures. The ewes were fed @entity0 325 mg daily. Duplex was performed at 2 months postoperatively to evaluate stent patency. SDT was defined as time from stay suture placement to arteriotomy closure. RESULTS: The 8 ewes weighed a mean (SD) of 34.4 (4.3) kg. The mean (SD) superficial femoral arterial was 4.3 (0.6) mm. @entity6 mm * 5 cm and two 6 mm * 5 cm Gore Viabahn stents were deployed. The mean (SD) SDT was 34 (19) minutes, with a trend toward less time with increasing experience (SDTmax, 60 minutes; SDTmin, 10 minutes). Duplex performed at 2 months postoperatively showed stent patency in five of eight stents. There was an association between increasing SDT and stent @entity3 . CONCLUSION: Open deployment of commercially available vascular stents to treat @entity5 is a conceptually sound and technically feasible alternative to standard open repair. Larger studies are needed to refine this technique and minimize stent complications, which are likely technical in nature.

title: The elimination of @entity2 in open XXXX vascular reconstruction: A novel technique using an animal model.

answer: @entity1


abstract: UNASSIGNED: The aim of this research was to investigate the impact of @entity3 channel blockers ( @entity4 ) on the formation of scars in the sciatic nerve @entity2 after @entity5 . One hundred twenty healthy, male @entity0 were selected and prepared with right @entity6 for this study. Samples were selected at the fourth and 12th weeks, respectively, after treatment and observations were made on the nerve @entity2 healing and diameter. Image analysis and statistical processing were carried out relating to the results of the study. The diameter of the @entity2 of the treatment group at weeks 4 and 12 was noticeably smaller than the control group (P   <   0.05). In the treatment group at week 4, there were many vesicles observed in the fibroblasts' cytosol and in the control group, the fibroblasts exhibited high number of rough endoplasmic reticulum. The collagen content of the nerve scarring at week 12 in the treatment group was apparently less than the control group (P   <   0.01). The @entity3 channel blocker ( @entity4 ) reduced the axon resistance through the @entity2 during nerve regeneration. It can effectively inhibit the formation of scarring from @entity1 . It also provided an excellent microenvironment for the regeneration of nerve fibers.

title: Inhibition of Peripheral Nerve Scarring by XXXX Antagonists, Also Known as @entity3 Channel Blockers.

answer: @entity3


abstract: UNASSIGNED: The aim of this research was to investigate the impact of @entity3 channel blockers ( @entity4 ) on the formation of scars in the sciatic nerve @entity2 after @entity5 . One hundred twenty healthy, male @entity0 were selected and prepared with right @entity6 for this study. Samples were selected at the fourth and 12th weeks, respectively, after treatment and observations were made on the nerve @entity2 healing and diameter. Image analysis and statistical processing were carried out relating to the results of the study. The diameter of the @entity2 of the treatment group at weeks 4 and 12 was noticeably smaller than the control group (P   <   0.05). In the treatment group at week 4, there were many vesicles observed in the fibroblasts' cytosol and in the control group, the fibroblasts exhibited high number of rough endoplasmic reticulum. The collagen content of the nerve scarring at week 12 in the treatment group was apparently less than the control group (P   <   0.01). The @entity3 channel blocker ( @entity4 ) reduced the axon resistance through the @entity2 during nerve regeneration. It can effectively inhibit the formation of scarring from @entity1 . It also provided an excellent microenvironment for the regeneration of nerve fibers.

title: Inhibition of Peripheral Nerve Scarring by @entity3 Antagonists, Also Known as XXXX Channel Blockers.

answer: @entity3


abstract: BACKGROUND: Numerous screening tools have been reported to aid in diagnosing @entity4 , but have poor severity prediction and lack accurate estimation of @entity2 or total length of hospital stay (LOS). AIM: This study aims at evaluating the utility of neutrophil-to-lymphocyte (NLR) ratio in predicting the severity of @entity4 , LOS and 30-day complication rates. METHODS: @entity0 who underwent appendicectomy over a 4-year period were evaluated. Demographics, blood results, severity of @entity4 , LOS and 30-day complications were recorded. Recommended cut-off values of NLR and @entity5 ( @entity5 ) for severity of @entity4 were determined using receiver operating characteristic analysis. The Mann-Whitney test was performed to assess the correlations between LOS and 30-day complications with NLR. RESULTS: A total of 663 @entity0 were included in the study of which 57.3% (n = 380) were male with mean @entity0 age of 23.6 years, and 461 appendix specimens (69.6%) had simple @entity1 on histological evaluation. A NLR of >6.35 or @entity5 of >55.6 were statistically associated with severe @entity3 , with a median of one extra hospital day admission (p < 0.0001). Mean NLR was statistically higher in @entity0 with postoperative co(13.69 for severe vs. 7.29 for @entity4 group, p = 0.016). CONCLUSION: We advocate that NLR is a useful adjunct in predicting severity of @entity4 . It aids in delineating severe @entity1 requiring surgery without substantial delay.

title: The Utility of Neutrophil-to-Lymphocyte Ratio as a Severity Predictor of XXXX , Length of Hospital Stay and Postoperative Complication Rates.

answer: @entity3


abstract: The need for a pretreatment staging system to accurately assess programs of therapy for the various sites and stages of childhood @entity2 has become apparent as detailed analyses of many factors affecting prognosis and treatment choices have been accomplished through the national cooperative trial, the Intergroup @entity2 Study (IRS). Initiated in 1972, the IRS has thus far used a clinicopathologic grouping system that is based heavily on therapeutic decisions, particularly on whether or not excision is accomplished and the extent of such an operation. The major problem with this and several other staging classifications now in use is that they depend on pathologic data obtained after surgical treatment has been initiated or rejected. In addition, they do not consider histologic variations of this @entity1 which may be important in estimating prognosis. The large body of clinical data now accumulated in the IRS has provided an excellent opportunity for developing a database for evaluating the International Union Against @entity1 (UICC) pretreatment staging system and also the potential for using histologic categories in the staging process. The records of 505 eligible @entity0 entered into the IRS between 1978 and 1982 were used to determine the prognostic impact of a number of pretreatment factors. These included local invasiveness of the primary @entity1 on clinical examination, @entity1 size, clinical status of regional nodes, clinical or radiologic evidence of distant metastases, and favorable or unfavorable histologic categories. A retrospective assessment of the relationship of these pretreatment observations to survival experience has been carried out. This retrospective study indicates definite prognostic significance for all of the individual factors used on the UICC system except clinical status of regional nodes. Also, these data serve as a basis for considering the possibility of including favorable v unfavorable histology in the pretreatment staging system now being tested prospectively in the ongoing IRS protocols.

title: Prognostic significance of staging factors of the UICC staging system in childhood @entity2 : a report from the Intergroup XXXX Study (IRS-II).

answer: @entity2


abstract: The need for a pretreatment staging system to accurately assess programs of therapy for the various sites and stages of childhood @entity2 has become apparent as detailed analyses of many factors affecting prognosis and treatment choices have been accomplished through the national cooperative trial, the Intergroup @entity2 Study (IRS). Initiated in 1972, the IRS has thus far used a clinicopathologic grouping system that is based heavily on therapeutic decisions, particularly on whether or not excision is accomplished and the extent of such an operation. The major problem with this and several other staging classifications now in use is that they depend on pathologic data obtained after surgical treatment has been initiated or rejected. In addition, they do not consider histologic variations of this @entity1 which may be important in estimating prognosis. The large body of clinical data now accumulated in the IRS has provided an excellent opportunity for developing a database for evaluating the International Union Against @entity1 (UICC) pretreatment staging system and also the potential for using histologic categories in the staging process. The records of 505 eligible @entity0 entered into the IRS between 1978 and 1982 were used to determine the prognostic impact of a number of pretreatment factors. These included local invasiveness of the primary @entity1 on clinical examination, @entity1 size, clinical status of regional nodes, clinical or radiologic evidence of distant metastases, and favorable or unfavorable histologic categories. A retrospective assessment of the relationship of these pretreatment observations to survival experience has been carried out. This retrospective study indicates definite prognostic significance for all of the individual factors used on the UICC system except clinical status of regional nodes. Also, these data serve as a basis for considering the possibility of including favorable v unfavorable histology in the pretreatment staging system now being tested prospectively in the ongoing IRS protocols.

title: Prognostic significance of staging factors of the UICC staging system in childhood XXXX : a report from the Intergroup @entity2 Study (IRS-II).

answer: @entity2


abstract: The immunohistochemical demonstration of neurofilament (NF) polypeptide was used to identify nerves in a series of 17 @entity3 . NF-positive fibres were present in two out of five @entity5 sited deep in the anterior lobe, in one out of five sited in the intermediate zone and in two out of seven non- @entity5 . Such nerve fibres were often seen in relation to blood vessels. The distribution of @entity4 immunoreactive cells was examined in 25 normal pituitaries and in 23 cases of @entity2 . Such cells were scattered throughout the normal gland and there was no increase in numbers in pregnancy. @entity4 was demonstrated in 18 @entity5 in @entity2 . There was no correlation with the site of the @entity1 or the presence of nerve fibres. @entity4 cells were distributed normally in the para-adenomatous gland. Crooke's hyaline change and @entity4 coexisted in some corticotrophs. These findings support the concept that 'intermediate lobe' function, as found in animals, has no discrete anatomical location in @entity0 .

title: A study of intermediate lobe differentiation in the XXXX pituitary gland.

answer: @entity0


abstract: AIM: @entity6 ( @entity6 ) is an important complication of @entity5 ( @entity5 ). The aim is to use indication and protocol biopsies to determine clinicopathological findings and outcomes of @entity0 with @entity6 undergoing kidney transplantation (KTx). METHODS: @entity0 who underwent KTx due to @entity6 were retrospectively analyzed. Recurrent @entity6 (RLN) was diagnosed by transplant kidney biopsy. RESULTS: Among 955 KTx @entity0 , 12 @entity0 with @entity6 as the cause of @entity2 were enrolled. Five @entity0 were male. Mean follow-up time was 63        34   months. At the last follow-up visit, mean levels of serum @entity4 and @entity3 were 137.0        69.0     mol/L and 0.26        0.26 gm/day, respectively. Eighteen indication and 22 protocol biopsies were performed; 27 of biopsies were additionally evaluated by immunofluorescence. In 2 recipients, subclinical RLN was confirmed by protocol biopsies. Clinical recurrence occurred in 4 @entity0 . Among @entity0 with RLN, time from diagnosis of @entity6 to KTx was significantly shorter and use of ATG as induction treatment was significantly lower. @entity1 occurred in 2 recipients who had clinical RLN. Five-year overall graft survival was 85.7%. CONCLUSIONS: KTx is a reasonable option for @entity0 with @entity2 secondary to @entity5 . However, recurrence of @entity6 is not rare if protocol biopsies are included in posttransplantation surveillance. This article is protected by copyright. All rights reserved.

title: Recurrent XXXX after transplantation: Clinicopathological evaluation with protocol biopsies.

answer: @entity6


abstract: BACKGROUND: International recommendations in favor of screening for @entity1 in pregnancy are based on heterogeneous criteria. In most developed countries, the diagnosis of @entity3 is only recommended for @entity0 with high-risk of @entity2 . The Nugent score is currently used, but molecular quantification tools have recently been reported with a high sensitivity and specificity. Their value for reducing @entity2 rates and related complications remains unexplored. This trial was designed to assess the cost-effectiveness of a systematic screen-and-treat program based on a point-of-care technique for rapid molecular diagnosis, immediately followed by an appropriate antibiotic treatment, to detect the presence of abnormal vaginal flora (specifically, Atopobium vaginae and @entity4 ) before 20  weeks of gestation in pregnant @entity0 in France. We hypothesized that this program would translate into significant reductions in both the rate of preterm births and the medical costs associated with @entity2 . METHODS/DESIGN: A multicenter, open-label randomized controlled trial (RCT) will be conducted in which 20 French obstetrics and gynecology centers will recruit eligible pregnant @entity0 at less than 20  weeks gestation with singleton pregnancy and with a low-risk factor for @entity2 . Interventions will include a) an experimental group that will receive a systematic rapid screen-and-treat program from a point-of-care analysis using a molecular quantification method and b) a control group that will receive usual care management. Randomization will be in a 1:1 allocation ratio. The primary endpoint that will be assessed over a period of 12  months will be the incremental cost-effectiveness ratio (ICER) expressed as cost per avoided @entity2 before 37  weeks. Secondary endpoints will include ICER per avoided @entity2 before 24, 28 and 32  weeks, obstetrical outcomes, neonatal outcomes, rates of treatment failure and recurrence episodes for positive @entity0 . Uncertainty surrounding these estimates will be addressed using nonparametric bootstrapping and represented using cost-effectiveness acceptability curves. A total of 6,800 pregnant @entity0 will be included. DISCUSSION: This appropriate randomized controlled design will provide insight into the cost-effectiveness and therefore the potential cost savings of a rapid screen-and-treat strategy for molecular abnormal vaginal flora in pregnant @entity0 . National and international recommendations could be updated based on the findings of this study. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02288832 (registration date: 30 October 2014); Eudract: 2014-001559-22.

title: Screen-and-treat program by point-of-care of Atopobium vaginae and XXXX in preventing @entity2 (AuTop trial): study protocol for a randomized controlled trial.

answer: @entity4


abstract: BACKGROUND: International recommendations in favor of screening for @entity1 in pregnancy are based on heterogeneous criteria. In most developed countries, the diagnosis of @entity3 is only recommended for @entity0 with high-risk of @entity2 . The Nugent score is currently used, but molecular quantification tools have recently been reported with a high sensitivity and specificity. Their value for reducing @entity2 rates and related complications remains unexplored. This trial was designed to assess the cost-effectiveness of a systematic screen-and-treat program based on a point-of-care technique for rapid molecular diagnosis, immediately followed by an appropriate antibiotic treatment, to detect the presence of abnormal vaginal flora (specifically, Atopobium vaginae and @entity4 ) before 20  weeks of gestation in pregnant @entity0 in France. We hypothesized that this program would translate into significant reductions in both the rate of preterm births and the medical costs associated with @entity2 . METHODS/DESIGN: A multicenter, open-label randomized controlled trial (RCT) will be conducted in which 20 French obstetrics and gynecology centers will recruit eligible pregnant @entity0 at less than 20  weeks gestation with singleton pregnancy and with a low-risk factor for @entity2 . Interventions will include a) an experimental group that will receive a systematic rapid screen-and-treat program from a point-of-care analysis using a molecular quantification method and b) a control group that will receive usual care management. Randomization will be in a 1:1 allocation ratio. The primary endpoint that will be assessed over a period of 12  months will be the incremental cost-effectiveness ratio (ICER) expressed as cost per avoided @entity2 before 37  weeks. Secondary endpoints will include ICER per avoided @entity2 before 24, 28 and 32  weeks, obstetrical outcomes, neonatal outcomes, rates of treatment failure and recurrence episodes for positive @entity0 . Uncertainty surrounding these estimates will be addressed using nonparametric bootstrapping and represented using cost-effectiveness acceptability curves. A total of 6,800 pregnant @entity0 will be included. DISCUSSION: This appropriate randomized controlled design will provide insight into the cost-effectiveness and therefore the potential cost savings of a rapid screen-and-treat strategy for molecular abnormal vaginal flora in pregnant @entity0 . National and international recommendations could be updated based on the findings of this study. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02288832 (registration date: 30 October 2014); Eudract: 2014-001559-22.

title: Screen-and-treat program by point-of-care of Atopobium vaginae and @entity4 in preventing XXXX (AuTop trial): study protocol for a randomized controlled trial.

answer: @entity2


abstract: BACKGROUND: Fever in @entity0 is one of the most common clinical symptoms and a chief complaint and a main reason that caregivers took the @entity0 to the outpatient service or admitted to hospital. Studies have found that the majority of parents surveyed at a hospital pediatric clinic held unrealistic and unwarranted concerns about fevers, first termed as ' @entity3 @entity4 ' by Schmitt in 1980. In the present study, we explore whether ' @entity3 @entity4 ' exists in Chinese caregivers and investigate whether such @entity4 is alleviated when admitted to hospital after propaganda of @entity3 related knowledge by doctors and nurses. METHODS: A questionnaire was distributed to caregivers of @entity0 who visited the pediatric outpatient department and those with caregivers in the wards between June 2012 and Feb 2013 in Wenzhou, China. RESULTS: Data were obtained from 621 caregivers, 305(49  %) from the OPD and 316(51  %) from the ward. Most caregivers of the two groups (OPD vs. ward group, 75.1 vs. 74.4  %) believed @entity3 could cause @entity1 . 77.7  % (76.0 vs. 81.3  %) caregivers were very worried when their @entity0 had @entity3 and 12.8  % (14.1 vs. 11.4  %) caregivers would check the temperature within 30  min. Moreover, 68.0  % (63.0 vs. 72.8  %, P   <   0.05) caregivers would give their children antipyretics during sleep and 39.9  % (40.3 vs. 39.6  %) would administrate antipyretics when temperature was above 38    C. After admitted to hospital, 83.9  % caregivers stated to have received education about @entity3 and 96.5  % felt relieved. Less caregivers (ward group vs. OPD, 42.4 vs. 46.9  %, P   <   0.05) from ward group would give antipyretics with a temperature under 38.5    C and less (0.6 vs. 4.9  %, P   <   0.05) preferred cold sponging as physical cooling method compared to the OPD caregivers. Alarmingly, more caregivers (42.7 vs. 34.3  %, P   <   0.05) in the ward group believed @entity3 could lead to death or/and @entity5 (17.4 vs. 10.5  %, P   <   0.05) and even 0.6  % caregivers in the ward group chose @entity2 when the @entity0 had @entity3 . CONCLUSION: 'Fever @entity4 ' also exists in Chinese caregivers. Fever related knowledge propaganda after admitted to hospital did not work effectively to improve the caregivers' understanding and management of @entity3 and an effective way to alleviate 'Fever @entity4 '.

title: Fever XXXX : a comparison survey between caregivers in the inpatient ward and caregivers at the outpatient department in a @entity0 's hospital in China.

answer: @entity4


abstract: BACKGROUND: Fever in @entity0 is one of the most common clinical symptoms and a chief complaint and a main reason that caregivers took the @entity0 to the outpatient service or admitted to hospital. Studies have found that the majority of parents surveyed at a hospital pediatric clinic held unrealistic and unwarranted concerns about fevers, first termed as ' @entity3 @entity4 ' by Schmitt in 1980. In the present study, we explore whether ' @entity3 @entity4 ' exists in Chinese caregivers and investigate whether such @entity4 is alleviated when admitted to hospital after propaganda of @entity3 related knowledge by doctors and nurses. METHODS: A questionnaire was distributed to caregivers of @entity0 who visited the pediatric outpatient department and those with caregivers in the wards between June 2012 and Feb 2013 in Wenzhou, China. RESULTS: Data were obtained from 621 caregivers, 305(49  %) from the OPD and 316(51  %) from the ward. Most caregivers of the two groups (OPD vs. ward group, 75.1 vs. 74.4  %) believed @entity3 could cause @entity1 . 77.7  % (76.0 vs. 81.3  %) caregivers were very worried when their @entity0 had @entity3 and 12.8  % (14.1 vs. 11.4  %) caregivers would check the temperature within 30  min. Moreover, 68.0  % (63.0 vs. 72.8  %, P   <   0.05) caregivers would give their children antipyretics during sleep and 39.9  % (40.3 vs. 39.6  %) would administrate antipyretics when temperature was above 38    C. After admitted to hospital, 83.9  % caregivers stated to have received education about @entity3 and 96.5  % felt relieved. Less caregivers (ward group vs. OPD, 42.4 vs. 46.9  %, P   <   0.05) from ward group would give antipyretics with a temperature under 38.5    C and less (0.6 vs. 4.9  %, P   <   0.05) preferred cold sponging as physical cooling method compared to the OPD caregivers. Alarmingly, more caregivers (42.7 vs. 34.3  %, P   <   0.05) in the ward group believed @entity3 could lead to death or/and @entity5 (17.4 vs. 10.5  %, P   <   0.05) and even 0.6  % caregivers in the ward group chose @entity2 when the @entity0 had @entity3 . CONCLUSION: 'Fever @entity4 ' also exists in Chinese caregivers. Fever related knowledge propaganda after admitted to hospital did not work effectively to improve the caregivers' understanding and management of @entity3 and an effective way to alleviate 'Fever @entity4 '.

title: Fever @entity4 : a comparison survey between caregivers in the inpatient ward and caregivers at the outpatient department in a XXXX 's hospital in China.

answer: @entity0


abstract: Antigestagens of RU-38.486-type were investigated in different pregnancy models reflecting either "endometrial" or "myometrial" effects. All antigestagens were found effective inhibitors of nidation in @entity0 . This was evidence for a role of embryonic @entity1 in the earliest events of nidation. No comparable inhibition could be obtained by ovariectomy. A more complex pharmacology was found around day 43 p.c. when the abortion was brought about by expulsion. RU-38.486 had marginal activity only. Antigestagens with reduced anti-glucocorticoid activity tended to induce abortions more effectively and faster. Some antigestagen- @entity2 combinations were found of extreme abortifacient activity. Surprisingly it seemed that anti-glucocorticoid properties in addition to (or rather than) antigestagenic activities bring about this synergism with @entity2 . The employed @entity0 model for pregnancy termination thus characterized two types of antigestagens: ideal ones for monotherapy or combined use with @entity2 , respectively. Antigestagens induced a highly sensitive myometrium to @entity2 -stimulation ( @entity3 ) and a marked softening and dilatation of the cervix. Antigestagens perfectly prime the genital tract for oxytocic stimuli, they do not overcome the arrested uterine @entity2 -secretion of the pregnant uterus at the same time.

title: Studies on the mechanisms of action of XXXX antagonists.

answer: @entity1


abstract: UNASSIGNED: @entity2 and @entity0 are regarded as distinct disorders in the current @entity4 . However, recent research and the RDoC initiative are recognizing considerable overlap in the clinical presentation of @entity2 , @entity0 , and other @entity1 . In spite of numerous neuroimaging findings in @entity2 and @entity0 , the extent to which either of the above views are supported remains equivocal. Here we compare structural MRI and DTI literature in @entity2 and @entity0 . Our main findings reveal both distinct and shared neural features. Distinct expressions were in total brain volume ( @entity2 : increased volume, @entity0 : decreased volume), amygdala ( @entity2 : overgrowth, @entity0 : normal), and internal capsule ( @entity2 : unclear, @entity0 : reduced FA in DTI). Considerable overlap was noted in the corpus callosum and cerebellum (lower volume in structural MRI and decreased FA in DTI), and superior @entity3 (reduced FA in DTI). In addition, we identify brain regions which have not been studied in depth and require more research. We discuss relationships between brain features and symptomatology. We conclude by addressing limitations of current neuroimaging research and offer approaches that account for clinical heterogeneity to better distinguish brain-behavior relationships.

title: A Comparison of Structural Brain Imaging Findings in Autism Spectrum Disorder and XXXX .

answer: @entity0


abstract: UNASSIGNED: Epidemiologic studies of @entity6 ( @entity6 ) in Eastern Europe are scarce in the literature. We report the experience of the "Ion Chiricuta" Institute of Oncology in Cluj-Napoca (IOCN), Romania, in the diagnosis and outcome of @entity0 with @entity6 . We studied 184 consecutive @entity6 @entity0 diagnosed in the Pathology Department of IOCN during the years 2004-2006. We also obtained epidemiological data from the Northwestern (NW) Cancer Registry. In the IOCN series, the most common @entity1 subtype was diffuse large @entity5 (43.5%), followed by the @entity7 /small @entity3 (21.2%). @entity2 represented a small proportion (8.2%). The median age of the @entity0 was 57   years, with a male-to-female ratio of 0.94. @entity0 with indolent @entity5 had the best overall survival, whereas those with @entity4 had the worst survival. The NW Cancer Registry data showed that the occurrence of @entity6 in the NW region of Romania was higher in @entity0 [world age-standardized incidence rate/100   000 (ASR)-5.9; 95% CI 5.1-6.6] than in @entity0 (ASR-4.1; 95% CI 3.5-4.7) with age-standardized male-to-female ratio of 1.44 (p   =   0.038). @entity7 /small @entity3 was the most common @entity6 in the NW region of Romania, accounting for 43% of all cases, followed by diffuse large @entity5 (36%). The 5-year, age-standardized cumulative relative survival for @entity6 in the County of Cluj in NW Romania, for the period of 2006-2010, was 51.4%, with 58.4% survival for @entity0 and 43.2% for @entity0 . Additional studies of @entity6 in Eastern Europe are needed. Copyright    2015 John Wiley _ Sons, Ltd.

title: XXXX in Romania: a single-centre experience.

answer: @entity6


abstract: UNASSIGNED: @entity3 occurs after approximately 2-20% of anterior cervical discectomy and fusion (ACDF) procedures; it is unclear if posterior or anterior revision should be pursued. In this study, we retrospectively evaluate the outcomes in 22 @entity0 with @entity3 following ACDF and revision via posterior cervical fusion (PCF). Baseline demographics, preoperative symptoms, operative data, time to fusion failure, symptoms of @entity3 , and revision method were assessed. Fusion outcome and clinical outcome were determined at last follow-up (LFU). Thirteen females (59%) and 9 (41%) males experienced @entity3 at a median of 11 (range: 3-151)months after ACDF. Median age at index surgery was 51 (range: 33-67)years. All @entity0 with @entity3 presented with progressive @entity4 , with median @entity2 ( @entity2 ) score of 8 (range: 0-10), and/or @entity5 . @entity0 with @entity3 <12months compared to >12months after index surgery were older (p=0.013), had more frequent preoperative @entity1 (p=0.064), and lower baseline @entity2 scores (p=0.006). Fusion was successful after PCF in all @entity0 , with median time to fusion of 10 (range: 2-14)months. Eighteen @entity0 fused both anteriorly and posteriorly, two @entity0 fused anteriorly only, and two @entity0 fused posteriorly only. Median @entity2 neck score at LFU significantly improved from the time of @entity3 (p=0.012). While uncommon, @entity3 may occur after ACDF. All @entity0 achieved successful fusion after subsequent posterior cervical fusion, with 91% fusing a previous anterior @entity3 after posterior stabilization. @entity4 significantly improved by LFU in the majority of @entity0 in this study.

title: Successful anterior fusion following posterior cervical fusion for revision of anterior cervical discectomy and fusion XXXX .

answer: @entity3


abstract: Fourteen @entity0 (15 joints) developed a foreign body reaction to @entity4 , @entity2 , or metal adjacent to a total joint implant, a condition we would like to term @entity3 . There were eight male and six female @entity0 . Their average age was 61 years. The hip was involved in 14 joints (femoral component 11 times, acetabulum 7, and greater trochanter once). One @entity0 presented with @entity3 of the knee. The principal findings included increasing @entity1 and radiographic evidence of loosening occurring on average 2.7 years following the implant. This was followed by a characteristic and gradually developing radiographic pattern of discrete rounded lucencies. These developed into large ovoid lytic areas, destroying both @entity4 and bone. Histologically, the appearances were characterized by histiocytic infiltration and the presence of multiple foreign body giant cells. Foreign material was identified in 9 of 11 cases. The pathogenesis is unknown but appears related to micromovement or loosening of the implant.

title: XXXX in total joint replacement.

answer: @entity3


abstract: UNASSIGNED: A 49-year-old @entity0 was admitted for an anterior @entity1 ( @entity1 ). At hospital arrival, she presented with @entity2 . An immediate coronary angiogram showed an occluded ostial left anterior descending artery. During percutaneous coronary intervention (PCI), @entity3 occurred requiring multiple electrical counter-shocks. The coronary artery was opened during cardiopulmonary resuscitation and two drug-eluting stents were implanted. At the end of the procedure, an Impella  CP(  ) mechanical cardiac-assist device was inserted. Rapid and marked improvement in the hemodynamic status was noted in the following days. The Impella  CP(  ) was withdrawn after five days and the @entity0 was discharged two weeks later. Despite limited data, mechanical cardiac assistance is recommended in @entity2 . Several devices are currently available; the choice of the system is based on the clinical presentation and the experience of each center. The Impella  CP(  ) is a microaxial pump which is inserted percutaneously and delivers up to 3.5L/min of continuous flow. In @entity2 due to @entity1 , this device allows temporary support while awaiting left ventricular recovery after primary PCI.

title: [Mechanical cardiac-assist devices in XXXX ].

answer: @entity1


abstract: UNASSIGNED: "Gamma-type carbonic anhydrase-like" (CAL) proteins form part of complex I in plants. Together with " @entity8 (CA) proteins they form an extra domain which is attached to the membrane arm of complex I on its matrix exposed side. In @entity2 two CAL and three CA proteins are present, termed @entity9 , CAL2, @entity6 , @entity7 and CA3. It has been proposed that the carbonic anhydrase domain of complex I is involved in a process mediating efficient recycling of mitochondrial @entity4 for photosynthetic @entity1 fixation which is especially important during growth conditions causing increased photorespiration. Depletion of CAL proteins has been shown to significantly affect plant development and photomorphogenesis. To better understand CAL function in plants we here investigated effects of CAL depletion on the mitochondrial compartment. In mutant lines and cell cultures complex I amount was reduced by 90-95% but levels of complexes III and V were unchanged. At the same time, some of the CA transcripts were less abundant. Proteome analysis of CAL depleted cells revealed significant reduction of complex I subunits as well as proteins associated with photorespiration, but increased amounts of proteins participating in @entity5 catabolism and stress response reactions. @entity0 of the mutants was slightly alleviated if plants were cultivated at high @entity4 . Profiling of selected metabolites revealed defined changes in intermediates of the @entity3 cycle and @entity5 catabolism. It is concluded that CAL proteins are essential for complex I assembly and that CAL depletion specifically affects central mitochondrial metabolism.

title: Depletion of the "gamma-type carbonic anhydrase-like" subunits of complex I affects central mitochondrial metabolism in XXXX .

answer: @entity2


abstract: UNASSIGNED: Carrier testing is widely available for multiple genetic conditions, and several professional organizations have created practice guidelines regarding appropriate clinical application and the testing of minors. Previous research has focused on carrier screening, predictive testing, and testing for @entity1 . However, family perspectives on carrier testing for @entity1 have yet to be described. In this study, we explored communication within the family about carrier testing and the perspectives of mothers of sons with an @entity1 , @entity2 ( @entity2 ). Twenty-five mothers of sons with @entity2 participated in an anonymous online survey. Survey questions included multiple choice, Likert scale, and open ended, short answer questions. Analysis of the multiple choice and Likert scale questions revealed that most mothers preferred a gradual style of communication with their daughters regarding risk status. In addition, most @entity0 reported having consulted with a genetic counselor and found it helpful. Comparisons between groups, analyzed using Fisher's exact tests, found no differences in preferred style due to mother's carrier status or having a daughter. Thematic analysis was conducted on responses to open ended questions. Themes identified included the impact of family implications, age and maturity, and a desire for autonomy regarding the decision to discuss and undergo carrier testing with at-risk daughters, particularly timing of these discussions. Implications for genetic counseling practice are discussed.

title: XXXX : a Survey of Perspectives on Carrier Testing and Communication Within the Family.

answer: @entity2


abstract: OBJECTIVES: @entity1 is a common cause of unplanned hospital admissions but there is little evidence on why, despite evidence-based interventions, admissions occur. This study aimed to identify critical points on @entity0 pathways where risk of admission is increased and identify barriers to the implementation of evidence-based interventions. DESIGN: Multicentre, longitudinal, @entity0 -led ethnography. SETTING: National Health Service settings across primary, community and secondary care in three geographical locations in England, UK. @entity0 : 31 @entity0 with severe or difficult to manage @entity1 followed for up to 11   months; 9 carers; 55 healthcare professionals. RESULTS: Fragmentation of healthcare, inequitable provision of services and poor continuity of care presented barriers to interventions for @entity1 . Critical points where a reduction in the risk of current or future admission occurred throughout the pathway. At the beginning some @entity0 did not receive a formal clinical diagnosis, in addition @entity0 lacked information about @entity1 , self-care and knowing when to seek help. Some clinicians lacked knowledge about diagnosis and management. Misdiagnoses of symptoms and discontinuity of care resulted in unplanned admissions. Approaching end of life, @entity0 were admitted to hospital when other options including palliative care could have been appropriate. CONCLUSIONS: Findings illustrate the complexity involved in caring for @entity0 with @entity1 . Fragmented healthcare and discontinuity of care added complexity and increased the likelihood of suboptimal management and unplanned admissions. Diagnosis and disclosure is a vital first step for the @entity0 in a journey of acceptance and learning to self-care/monitor. The need for clinician education about @entity1 and specialist services was acknowledged. @entity0 education should be seen as an ongoing 'conversation' with trusted clinicians and end-of-life planning should be broached within this context.

title: Unplanned admissions and the organisational management of XXXX : a multicentre ethnographic, qualitative study.

answer: @entity1


abstract: BACKGROUND: @entity4 ( @entity4 ) is the most severe form of @entity2 , but limited literature exists on readmission after @entity4 . We aimed to assess frequencies, causes, and predictors of early and late readmissions within 1 year after @entity4 . METHODS: All @entity0 admitted to the Department of Neurology at Haukeland University Hospital with acute @entity2 were prospectively included in the Bergen Norwegian @entity2 Research Registry (NORSTROKE) registry. Surviving @entity0 diagnosed with @entity4 were followed by medical chart reviews for 1 year. The first unplanned readmission was used as final outcome, and readmitted @entity0 were defined as early readmitted ( <=90 days) and late readmitted (91-365 days). Logistic regression was performed to assess predictors for early and late readmission. RESULTS: Of 121 @entity0 discharged alive, 27 were early readmitted, and 17 were late readmitted. Within 1 year, 40.6% had at least 1 unplanned readmission. The most frequent cause of early readmission was infection, and the most frequent causes for late readmission were recurrent @entity2 and @entity3 . Nursing home discharge was the only independent predictor of early readmission. @entity1 and increased length of the index admission were independent predictors of late readmission. Early readmitted @entity0 were older and had more severe @entity2 and lower levels of @entity5 on index admission compared with @entity0 who were readmitted late. CONCLUSIONS: Readmission after @entity4 is frequent, and many @entity0 are early readmitted. Early and late readmissions differed in both causes and predictors for readmission, reflecting different underlying mechanisms for readmission.

title: Hospital Readmission after XXXX .

answer: @entity4


abstract: AIM: to determine tomography findings in optic nerve head (ONH) and retinal nerve fiber layer (RFNL) that may be valuable for differential diagnosis between normal-tension @entity1 (NTG) and @entity3 ( @entity3 ) outcome. MATERIAL AND METHODS: Group 1 consisted of 17 @entity0 (32 eyes) with NTG, group 2--17 @entity0 (24 eyes) with @entity3 outcome. The control group included 22 @entity0 (22 eyes) with no sighs of @entity3 . Optic nerve head and retina assessment included scanning laser ophthalmoscopy (HRT 111) and optical coherence tomography (Stratus @entity4 3000). Statistical analyses were performed using Statistica 10 software suite. RESULTS: Statistically significant changes in HRT parameters, namely, the mean RNFL thickness, retinal height variation along the contour line, and @entity2 discriminant function, were observed in both study groups as compared to the controls. NTG @entity0 also showed lower rim indices, larger cups, smaller values of the FSM discriminant function, and lower @entity1 ( @entity1 ) than both @entity3 @entity0 and the controls. @entity4 findings included a statistically significant decrease in RNFL thickness in both study groups as compared to the controls. As for the difference between the groups, it was unreliable. Quadrant comparisons of RNFL thicknesses revealed that lower quadrant RNFL thinning was more significant in NTG @entity0 , while temporal quadrant RNFL thinning--in @entity3 @entity0 . CONCLUSION: Both conditions are associated with a similar degree of RNFL thinning, as confirmed by @entity4 , however, HRT changes are much more pronounced in NTG than in @entity3 @entity0 .

title: [Tomography findings in optic nerve head and retina in differential diagnosis between normal-tension @entity1 and XXXX ].

answer: @entity3