abstract: UNASSIGNED: Objectives Progestogen-only pills (POPs) are safer with respect to cardiovascular risks than contraceptives containing @entity1 . Despite the increased contraceptive efficacy of a @entity6 -only pill compared with a traditional POP, POPs are still not widely used due to an unpredictable @entity2 pattern. A new POP containing 4 mg @entity5 has been developed with a 24/4 intake regimen which may improve the @entity2 pattern. The objectives of this study were to investigate ovulation inhibition with the new @entity5 -only pill in comparison with the @entity6 -only pill and, in addition, to assess the effects on cervical mucus permeability and @entity2 . Methods Sixty-four healthy volunteers with proven ovulatory cycles were randomised and treated with either the @entity5 -only or the @entity6 -only pill during two 28-day cycles. Follicular diameter, endometrial thickness, and serum @entity0 (E2) and @entity3 concentrations were measured and Hoogland scores were determined. Additionally, cervical mucus scores, @entity2 and return of ovulation were assessed. Results Both treatments effectively inhibited ovulation. Follicular diameter, E2 levels and Hoogland scores were equal, demonstrating @entity4 . One subject in each group had a Hoogland score of 6, but the criteria for normal luteal activity were not fulfilled. In both groups, ovulation did not occur before day 9 of the post-treatment cycle. Cervical mucus permeability was suppressed in both groups. The median number of @entity2 and spotting days was lower in the @entity5 group. Conclusions The new @entity5 -only pill inhibited ovulation as effectively as the @entity6 -only pill despite the 4-day hormone-free interval.

title: A randomised study comparing the effect on ovarian activity of a progestogen-only pill (POP) containing @entity6 and a new POP containing XXXX in a 24/4 regimen.

answer: @entity5


abstract: The role of second-look laparotomy in management of advanced @entity2 is still controversial. One of the arguments against this method is the risk of this wide operation. Replacement of second-look laparotomy by laparoscopy maybe the way to minimize that risk. The aim of this report is the comparison of second-look laparotomy and laparoscopy. The prospectively gathered material consists of 56 @entity0 with @entity2 , 17 of them were qualified for second-look procedures. Laparoscopy was the first step in this procedure. In 5 @entity0 the residual @entity1 in abdominal cavity was found. In 11 there were no evidence of the disease, and in 1 case laparoscopic inspection was impossible. When the laparoscopy was negative or impossible the second-look laparotomy was performed. Only in one case after negative laparoscopy the evidence of @entity1 during laparotomy was found. In our opinion: 1) Positive second-look laparoscopy is equivalent to laparotomy and permits to avoid it. 2) The negative second-look laparoscopy with its contemporary technique still requires the subsequent laparotomy.

title: [The place of second-look laparoscopy in monitoring treatment of XXXX ].

answer: @entity2


abstract: BACKGROUND AND PURPOSE: Medial @entity4 with unilateral @entity1 (MTLE- @entity5 ) is the most frequent form of surgical @entity4 . In this study, it was aimed to determine whether different @entity2 represent a cardinal and characteristic feature of MTLE- @entity5 and might provide a diagnostic complement to help identify @entity0 who will be @entity3 -free after surgery. METHODS: All types of auras and associations of auras reported by 400 MTLE- @entity5 @entity0 referred for surgery were retrospectively collected and their statistical correlation with the postoperative outcome was examined in a subgroup of 305 @entity0 who underwent surgery. RESULTS: A total of 876 auras were collected, classified into 12 categories. Globally, MTLE- @entity5 @entity0 reported widely variable auras and groupings of auras. Most common were autonomic and abdominal visceral auras, followed by psychoaffective and experiential auras; less common, but seen in 10%-15% of @entity0 , were non-specific auras, @entity2 , and least common, reported by less than 10% of @entity0 , were auditory, gustatory, vestibular, olfactory and intellectual auras. No auras were reported in 10% of @entity0 . 65% of @entity0 experienced more than one type of aura (two to seven). No specific groupings of aura type were apparent. No evidence was found for correlation between postoperative outcome and (i) any @entity2 , (ii) the number of categories of aura per @entity0 and (iii) any association of categories of auras. CONCLUSION: Auras and association of auras vary widely in MTLE- @entity5 and provide no useful insight into surgical outcome.

title: Are auras a reliable clinical indicator in medial @entity4 with XXXX ?

answer: @entity1


abstract: BACKGROUND AND PURPOSE: Medial @entity4 with unilateral @entity1 (MTLE- @entity5 ) is the most frequent form of surgical @entity4 . In this study, it was aimed to determine whether different @entity2 represent a cardinal and characteristic feature of MTLE- @entity5 and might provide a diagnostic complement to help identify @entity0 who will be @entity3 -free after surgery. METHODS: All types of auras and associations of auras reported by 400 MTLE- @entity5 @entity0 referred for surgery were retrospectively collected and their statistical correlation with the postoperative outcome was examined in a subgroup of 305 @entity0 who underwent surgery. RESULTS: A total of 876 auras were collected, classified into 12 categories. Globally, MTLE- @entity5 @entity0 reported widely variable auras and groupings of auras. Most common were autonomic and abdominal visceral auras, followed by psychoaffective and experiential auras; less common, but seen in 10%-15% of @entity0 , were non-specific auras, @entity2 , and least common, reported by less than 10% of @entity0 , were auditory, gustatory, vestibular, olfactory and intellectual auras. No auras were reported in 10% of @entity0 . 65% of @entity0 experienced more than one type of aura (two to seven). No specific groupings of aura type were apparent. No evidence was found for correlation between postoperative outcome and (i) any @entity2 , (ii) the number of categories of aura per @entity0 and (iii) any association of categories of auras. CONCLUSION: Auras and association of auras vary widely in MTLE- @entity5 and provide no useful insight into surgical outcome.

title: Are auras a reliable clinical indicator in medial XXXX with @entity1 ?

answer: @entity4


abstract: UNASSIGNED: @entity4 is a devastating disease. Despite its clinical importance, the pathophysiology of @entity4 is not well understood. @entity3 expansion occurs in a large subset of @entity0 and is a predictor of poor outcomes. Since @entity3 growth provides a potential opportunity for therapeutic intervention, a thorough understanding of its biological mechanisms is of key importance. After vessel rupture, an initial @entity3 forms. Following this initial phase, accumulating evidence suggests that the mass effect causes secondary vessel rupture, which contributes to the @entity3 and may trigger an @entity1 . The circumstances under which this occurs and to what extent secondary @entity2 contributes to final @entity3 volume remain unknown, however. To address these questions, a translational approach seems most suitable. Current experimental models include intracranial injections of collagenase or autologous blood. Each has individual strengths and weaknesses in its ability to simulate @entity0 @entity4 . The ultimate goal for improved understanding and modeling of the pathophysiology of @entity3 expansion is to identify new treatment approaches.

title: The Pathophysiology of XXXX Formation and Expansion.

answer: @entity4


abstract: OBJECTIVE: Assess algorithms for linking @entity0 across de-identified databases without compromising confidentiality. DATA SOURCES/STUDY SETTING: Hospital discharges from 11 Mayo Clinic hospitals during January 2008-September 2012 (assessment and validation data). Minnesota death certificates and hospital discharges from 2009 to 2012 for entire state (application data). STUDY DESIGN: Cross-sectional assessment of sensitivity and positive predictive value ( @entity1 ) for four linking algorithms tested by identifying readmissions and posthospital mortality on the assessment data with application to statewide data. DATA COLLECTION/EXTRACTION METHODS: De-identified claims included @entity0 gender, birthdate, and zip code. Assessment records were matched with institutional sources containing unique identifiers and the last four digits of Social Security number (SSNL4). PRINCIPAL FINDINGS: Gender, birthdate, and five-digit zip code identified readmissions with a sensitivity of 98.0 percent and a @entity1 of 97.7 percent and identified postdischarge mortality with 84.4 percent sensitivity and 98.9 percent @entity1 . Inclusion of SSNL4 produced nearly perfect identification of readmissions and deaths. When applied statewide, regions bordering states with unavailable hospital discharge data had lower rates. CONCLUSION: Addition of SSNL4 to administrative data, accompanied by appropriate data use and data release policies, can enable trusted repositories to link data with nearly perfect accuracy without compromising @entity0 confidentiality. States maintaining centralized de-identified databases should add SSNL4 to data specifications.

title: Incorporating the Last Four Digits of Social Security Numbers Substantially Improves Linking XXXX Data from De-identified Hospital Claims Databases.

answer: @entity0


abstract: BACKGROUND: We examined the presurgical evaluation of suspected @entity1 @entity0 in a community-based health care system to establish current benchmarks of care that will lay the groundwork for an evidence-based quality improvement project. METHODS: We retrospectively reviewed clinical records of all recipients of lung resection at two institutions, and classified all @entity1 relevant procedures into five "nodal points": lesion detection, diagnostic biopsy, radiologic staging, invasive staging, and treatment. We analyzed the frequency of passage through each nodal point, the time intervals between nodal points, and the use of staging modalities. RESULTS: Of 614 eligible @entity0 , 92% had @entity1 , 5% had a @entity1 , 3% had a benign lesion. Six percent received preoperative therapy; 39% of  resections were minimally invasive. Ninety-eight percent of @entity0 had a preoperative computed tomography (CT) scan, 27% had no preoperative diagnostic procedure, 22% had no preoperative positron emission tomography (PET)/CT scans, and 88% had no invasive preoperative staging test. Only 10% had trimodality staging with CT, PET/CT, and invasive staging. Twenty-one percent of @entity0 who had an invasive staging test had mediastinal nodal metastasis at resection. The median duration (interquartile range) from initial lesion identification to resection was 84 days (43 to 189) days; from lesion identification to diagnostic biopsy, 28 days (7 to 96); and from diagnostic biopsy to surgery, 40 days (26 to 69). CONCLUSIONS: There is opportunity for improvement in the thoroughness, accuracy, and timeliness of preoperative evaluation of suspected @entity1 @entity0 in this community cohort. Better coordination of care may significantly improve these benchmarks.

title: Preoperative Evaluation of XXXX in a Community Health Care Setting.

answer: @entity1


abstract: PURPOSE: To assess the impact of comprehensive palliative care on @entity0 ' quality of life. The intervention was based on cooperation between a palliative medicine unit and the community service and was compared with conventional care. @entity0 AND METHODS: A cluster randomized trial was carried out, with community health care districts defined as the clusters. @entity0 from these districts who had @entity1 and survival expectancy between 2 to 9 months were entered onto the trial. The main quality-of-life end points were physical and emotional functioning, @entity2 , and psychologic distress assessed monthly by using the European Organization for Research and Treatment of @entity1 Quality of Life Questionnaire-C30 (EORTC QLQ-C30) questionnaire and Impact of Event scale (IES). In total, 235 intervention @entity0 and 199 controls were included. RESULTS: During the initial 4 months of follow-up, the compliance was good (72%) and comparable among treatment groups. No significant differences on any of the quality-of-life scores were found. At later assessments and for scores that were made within 3 months before death, there was also no consistent tendency in favor of any treatment group on the main outcomes or other EORTC QLQ-C30 scales/items. CONCLUSION: A general program of palliative care may be important to ensure flexibility and to meet the needs of terminally ill @entity0 . However, to achieve improvements on a group level of the various dimensions of quality of life, specific interventions directed toward specific symptoms or problems may have to be defined, evaluated, and included in the program.

title: Quality of life in XXXX care: results from a cluster randomized trial.

answer: @entity1


abstract: Neurotrophins cooperate with neural activity to modulate CNS neuronal survival and dendritic differentiation. In a previous study, we demonstrated that a critical balance of @entity0 and neural activity is required for Purkinje cell survival in cocultures of purified granule and Purkinje cells (Morrison and Mason, 1998). Here we investigate whether @entity1 signaling regulates dendrite and spine development of Purkinje cells. @entity0 treatment of purified Purkinje cells cultured alone did not elicit formation of mature dendrites or spines. In cocultures of granule and Purkinje cells, however, continuous treatment with @entity0 over a 2 week postnatal culture period increased the density of Purkinje cell dendritic spines relative to controls without causing a shift in the proportions of headed and filopodia-like spines. The increase in spine number was blocked by adding @entity1 -IgG to the medium together with @entity0 . Although @entity0 alone did not consistently modify the morphology of dendritic spines, treatment with @entity1 -IgG alone yielded spines with longer necks than those in control cultures. None of these treatments altered Purkinje cell dendritic complexity. These analyses reveal a role for @entity1 signaling in modulating spine development, consistent with recently reported effects of neurotrophins on synaptic function. Moreover, spine development can be uncoupled from dendrite outgrowth in this reductionist system of purified presynaptic and postsynaptic neurons.

title: XXXX signaling modulates spine density and morphology independent of dendrite structure in cultured neonatal Purkinje cells.

answer: @entity1


abstract: @entity6 ( @entity6 ) is an @entity2 of erythroid progenitor cells resulting in elevated erythrocyte mass. Several mutations of the @entity5 ( @entity5 ) gene have been associated with @entity6 , although in a few families the linkage between the @entity5 gene and @entity6 has been excluded. To examine the role of @entity5 mutations in the pathogenesis of @entity6 , we studied 43 unrelated @entity6 subjects. Erythroid culture data were available in 26 subjects, and in all these subjects, we observed @entity1 of erythroid progenitors to @entity3 (EPO). We screened all @entity5 gene exons for mutations using ribonuclease cleavage assay and protein truncation test. We detected five mutations in exon VIII of the @entity5 gene, four of which we reported earlier. A new @entity5 gene mutation was found ( @entity7 ) that changes codon 425 GAG to a termination codon, resulting in truncation of the @entity5 by 84 @entity4 . The @entity7 mutation was found to segregate with the disease in the affected family and represents another example of a nonsense mutation associated with @entity6 . We also report the first intronic mutation ( @entity8 ) of the @entity5 gene. The finding of only five disease-causing mutations in our @entity6 @entity0 pool of 43 subjects (12%) indicates that @entity5 gene mutations are not the major @entity2 associated with @entity6 . The @entity1 of erythroid progenitors to EPO seen in all examined @entity6 subjects suggests a dominant lesion of an as yet unidentified gene either at the level of the @entity5 signaling pathway or another erythropoiesis regulating pathway.

title: Genetic heterogeneity of primary XXXX .

answer: @entity6


abstract: In both primates and rodents, the prefrontal cortex (PFC) is highly innervated by dopaminergic fibers originating from the ventral tegmental area, and activation of this mesocortical dopaminergic system decreases spontaneous and evoked activity in the PFC in vivo. We have examined the effects of @entity1 (DA), over a range of concentrations, on the passive and active membrane properties of layer V pyramidal cells from the @entity0 medial PFC (mPFC). Whole-cell and perforated-patch recordings were made from neurons in @entity0 mPFC. As a measure of cell excitability, trains of action potentials were evoked with 1-sec-long depolarizing current steps. Bath application of DA (0.05-30 microM) produced a reversible decrease in the number of action potentials evoked by a given current step. In addition, DA reversibly decreased the input @entity3 ( @entity3 ) of these cells. In a subset of experiments, a transient increase in excitability was observed after the washout of DA. Control experiments suggest that these results are not attributable to changes in spontaneous synaptic activity, age-dependent processes, or strain-specific differences in dopaminergic innervation and physiology. Pharmacological analyses, using D1 agonists ( @entity2 and @entity6 ), a D1 antagonist ( @entity5 ), a D2 receptor agonist ( @entity7 ), and a D2 antagonist ( @entity4 ) suggest that decreases in spiking and @entity3 are mediated by D2 receptor activation. Together, these results demonstrate that DA, over a range of concentrations, has an inhibitory effect on layer V pyramidal neurons in the @entity0 mPFC, possibly through D2 receptor activation.

title: XXXX decreases the excitability of layer V pyramidal cells in the @entity0 prefrontal cortex.

answer: @entity1


abstract: In both primates and rodents, the prefrontal cortex (PFC) is highly innervated by dopaminergic fibers originating from the ventral tegmental area, and activation of this mesocortical dopaminergic system decreases spontaneous and evoked activity in the PFC in vivo. We have examined the effects of @entity1 (DA), over a range of concentrations, on the passive and active membrane properties of layer V pyramidal cells from the @entity0 medial PFC (mPFC). Whole-cell and perforated-patch recordings were made from neurons in @entity0 mPFC. As a measure of cell excitability, trains of action potentials were evoked with 1-sec-long depolarizing current steps. Bath application of DA (0.05-30 microM) produced a reversible decrease in the number of action potentials evoked by a given current step. In addition, DA reversibly decreased the input @entity3 ( @entity3 ) of these cells. In a subset of experiments, a transient increase in excitability was observed after the washout of DA. Control experiments suggest that these results are not attributable to changes in spontaneous synaptic activity, age-dependent processes, or strain-specific differences in dopaminergic innervation and physiology. Pharmacological analyses, using D1 agonists ( @entity2 and @entity6 ), a D1 antagonist ( @entity5 ), a D2 receptor agonist ( @entity7 ), and a D2 antagonist ( @entity4 ) suggest that decreases in spiking and @entity3 are mediated by D2 receptor activation. Together, these results demonstrate that DA, over a range of concentrations, has an inhibitory effect on layer V pyramidal neurons in the @entity0 mPFC, possibly through D2 receptor activation.

title: @entity1 decreases the excitability of layer V pyramidal cells in the XXXX prefrontal cortex.

answer: @entity0


abstract: INTRODUCTION: Development of an incisional @entity2 after abdominal surgery is a common complication following laparotomy. Following recent advancements in laparoscopic and open repair a literature review has demonstrated no difference in the short term outcomes between open and laparoscopic repair, concluding there was no favourable method of repair over the other and that both techniques are appropriate methods of surgical repair. However, long term outcomes in the available literature between these two approaches were not clearly analysed or described. The objective of this study is to assess the effectiveness and safety of laparoscopic versus open @entity3 , and to evaluate the short and long term outcomes in regards to @entity2 using meta-analysis of all randomised controlled trials from 2008 to end of 2013. STUDY AIMS AND OBJECTIVES: Population: @entity0 who developed an @entity3 or @entity3 following a laparotomy. INTERVENTION: Two methods of surgical repair, laparoscopic and open @entity3 repair. Comparison: To compare between laparoscopic and open repair in abdominal wall incisional @entity2 . OUTCOME: length of hospital stay, operation time, wound @entity1 and @entity2 rate. METHODS: This study is a systematic review on all randomized controlled trials of laparoscopic versus open abdominal wall and incisional @entity2 repair. Medline, Pubmed, Cochrane library, Cinahl and Embase were the databases interrogated. Inclusion _ exclusion criteria had been defined. The relevant studies identified from January 2008 to December 2013, are included in the analysis. The primary end point can be described as @entity2 , and secondary outcomes can be described as length of hospital stay post operatively, operation time and wound @entity1 . RESULTS: Five randomized controlled trials (RCTs) were identified and included in the final analysis with a total number of 611 @entity0 randomized. Three hundreds and six @entity0 were in the laparoscopic group and 305 @entity0 in the open repair group. The range of follow up in the studies was two months to 35 months. The recurrence rate was similar (P  =  0.30), wound @entity1 was higher in the open repair group (P  <  0.001), length of hospital stay was not statistically different (P  =  0.92), and finally the operation time was longer in the laparoscopic group but did not reach statistical significance (P  =  0.05) CONCLUSION: The short and long-term outcomes of laparoscopic and open @entity3 repairs are equivalent; both techniques are safe and credible and the outcomes are very comparable.

title: A systematic review of laparoscopic versus open XXXX , with meta-analysis of randomized controlled trials.

answer: @entity3


abstract: BACKGROUND: The ideal operation to treat @entity2 is still far to define. We analyzed the outcomes of the Desarda tissue-based repair in comparison with the standard Lichtenstein procedure in treatment of primary @entity2 . METHODS: A total of 168 @entity0 were randomly allocated into two groups to undergo one of two repairs: Desarda (group I) or Lichtenstein (group II) (85 vs. 83, respectively). The primary outcome measures were recurrence of @entity6 . Secondary outcome measures included operating time, @entity4 scores, time to return to normal gait and to work, @entity5 in the groin, and @entity3 . RESULTS: During 2-year follow up, one recurrence was detected in each group (P  =  0.99). Chronic groin @entity1 was experienced by 5.6% and 4.2% of @entity0 from Desarda and Lichtenstein groups respectively (P  =  0.68). There was no significant statistical difference in mean postoperative VAS scores for @entity1 at the five time points between the two study groups. There was significantly shorter operating time and earlier return to normal gait in favor of Desarda repair. @entity5 was not different between the two groups. CONCLUSION: Successful @entity2 treatment without mesh implantation can be achieved using Desarda repair, as it is effective as the standard Lichtenstein procedure. Shorter operating time, early return to normal gait and lower cost (no mesh) are potential benefits of Desarda repair. The suitability of Desarda repair for @entity0 found to have thin, weak or divided external oblique aponeurosis intraoperatively needs further evaluation.

title: Randomized clinical trial of Desarda versus Lichtenstein repair for treatment of primary XXXX .

answer: @entity2


abstract: @entity2 frustrates @entity0 and treating physicians. Our hypothesis was that use of a dorsiflexion night splint for 1 month would effectively treat @entity0 with @entity2 . A 6-month randomized crossover study included 37 @entity0 with @entity2 . @entity0 were treated with dorsiflexion night splints for 1 month. Group A wore splints for the 1st month and group B for the 2nd month. No splints were used in either group for the final 4 months of the study. No other medications, stretching, or strengthening exercises were prescribed. Eighty-eight percent of @entity0 who completed the study improved. Eighty percent of the involved feet improved subjectively. Results of the AOFAS Ankle-Hindfoot Rating System and the Mayo Clinical Scoring System demonstrated significant improvement for both groups during the period of splint wear. Improvements were maintained at study completion. Response to splinting did not correlate with foot type, degree of @entity1 , or the presence of heel spur on radiographs. We believe dorsiflexion splints provide relief from the symptoms of @entity2 in the majority of @entity0 .

title: Effective treatment of XXXX with dorsiflexion night splints: a crossover prospective randomized outcome study.

answer: @entity2


abstract: PEP (Peer Education Programme) Talk: @entity1 , Healthy Feet and You is a peer-led self-management programme developed to address the problems of growing prevalence of @entity1 and its complications, and limited health care dollars. An evaluation of the programme, how it might be situated within a public health perspective and potential bridges for its implementation in communities throughout @entity2 and worldwide, are presented. The programme consisted of workshops that were conducted by volunteer peer leaders and health care professionals in 12 communities in 10 Canadian provinces; the volunteers were supported through monthly mentoring teleconferences, on-line tips and discussion board conversations. A web portal was developed to be used by the team, volunteers and community @entity0 . Workshop curriculum was developed based on @entity1 footcare and self-management best practise guidelines. Community @entity0 answered pre-and post-workshop statements that indicated that learning occurred, as indicated by an increase in the number of statements answered correctly. @entity0 ' feedback about the workshops was positive. In telephone follow-up interviews, 97% of respondents reported having changed their foot self-management behaviours. The portal was commonly used according to website visits, but not as much as expected for registration of community @entity0 . It is recommended that this programme be made widely available and tailored to the specific needs of the communities and that further evaluation be conducted.

title: Evaluation of a peer-led self-management education programme PEP Talk: XXXX , Healthy Feet and You.

answer: @entity1


abstract: Results to date indicate that @entity1 ( @entity1 ) with autologous stem cell support improves survival of @entity0 with symptomatic @entity4 ( @entity4 ). We performed a multicenter, sequential, randomized trial designed to assess the optimal timing of @entity1 and autotransplantation. Among 202 enrolled @entity0 who were up to 56 years old, 185 were randomly assigned to receive @entity1 and peripheral blood stem cell (PBSC) autotransplantation (early @entity1 group, n = 91) or a conventional-dose chemotherapy (CCT) regimen (late @entity1 group, n = 94). In the late @entity1 group, @entity1 and transplantation were performed as rescue treament, in case of primary resistance to CCT or at relapse in responders. PBSC were collected before randomization, after mobilization by chemotherapy, and, in the two groups, @entity1 was preceded by three or four treatments with @entity6 , @entity3 , and @entity5 . Data were analyzed on an intent-to-treat basis using a sequential design. Within a median follow-up of 58 months, estimated median overall survival (OS) was 64.6 months in the early @entity1 group and 64 months in the late group. Survival curves were not different (P = .92, log-rank test). Median event-free survival (EFS) was 39 months in the early @entity1 group whereas median time between randomization and CCT failure was 13 months in the late group. Average time without symptoms, treatment, and treatment @entity2 (TWiSTT) were 27.8 months (95% confidence interval [CI]; range, 23.8 to 31.8) and 22.3 months (range, 16.0 to 28.6) in the two groups, respectively. @entity1 with PBSC transplantation obtained a median OS exceeding 5 years in young @entity0 with symptomatic @entity4 , whether performed early, as first-line therapy, or late, as rescue treatment. Early @entity1 may be preferred because it is associated with a shorter period of chemotherapy.

title: High-dose therapy and autologous peripheral blood stem cell transplantation in XXXX : up-front or rescue treatment? Results of a multicenter sequential randomized clinical trial.

answer: @entity4


abstract: INTRODUCTION: @entity4 ( @entity4 ) is an uncommon condition. The main symptom is @entity1 which appears on standing and is relieved by lying down. Diagnosis is confirmed if a CSF pressure of less than 6 cm of water is found in the absence of other causes of @entity2 . OBJECTIVE: To describe the cranial MR and CT findings of 7 cases with @entity4 . MATERIAL AND METHODS: We studied 7 @entity0 in whom the diagnosis had been confirmed by lumbar puncture. The findings of 5 cranial CT studies (not using contrast), 5 MR without @entity3 and 4 MR with @entity3 were studied. The CT were carried out during the first week after clinical signs appeared, and the MR at between 1 week and 4 months after onset. We reviewed previous findings in the literature. RESULTS: 1. Cranial CT: in one case there was an enlarged subarachnoid space; 2. MR without @entity3 : there was descent of the cerebellar tonsils in 4 @entity0 , meningeal thickening in 5 cases and subdural collections in two @entity0 . In no case was descent of the iter seen; 3. MR with @entity3 : aural contrast was taken up in all cases. CONCLUSIONS: The CT without contrast done at the onset of the condition did not usually give data which was useful for diagnosis. The principal MR findings in our series (meningeal thickening, descent of the cerebellar tonsils, subdural collections and @entity3 uptake) in an appropriate clinical context may be sufficient for diagnosis of this condition before lumbar puncture.

title: [ XXXX . Radiological findings].

answer: @entity4


abstract: BACKGROUND: Various @entity2 cause @entity6 associated with @entity4 and @entity3 . Here, we set out to identify the @entity2 in a consanguineous Omani family with three affected @entity0 in whom mutations in known candidate genes had been excluded beforehand. METHODS: For mutation screening, we combined autozygosity mapping and whole exome sequencing. Segregation of potential disease variants with the phenotype was verified by Sanger sequencing. A splice-site mutation was confirmed and quantified by qPCR. RESULTS: We found an autosomal recessive splice acceptor mutation in @entity7 ( @entity8 , @entity9 ) in all affected individuals, which led to exon skipping, and reduced the normal full-length mRNA copy number in the @entity0 to 5% of the wild-type level. Besides @entity4 and @entity6 , two of three affected siblings suffered from severe @entity3 . All @entity0 exhibited @entity5 of the limbs coinciding with symmetric T2 hyperintensities of the basal ganglia on cranial MRI. CONCLUSIONS: A recent report has shown dominant @entity7 mutations to occur de novo in @entity0 with @entity4 . Here, we demonstrate that a @entity7 -associated disorder can also be inherited as an autosomal recessive trait with heterozygous individuals being entirely healthy. Our findings expand the clinical and genetic spectrum of @entity7 mutations to comprise @entity3 and @entity1 .

title: Recessive @entity7 mutation associates with @entity6 , @entity4 , @entity1 and XXXX .

answer: @entity3


abstract: BACKGROUND: Various @entity2 cause @entity6 associated with @entity4 and @entity3 . Here, we set out to identify the @entity2 in a consanguineous Omani family with three affected @entity0 in whom mutations in known candidate genes had been excluded beforehand. METHODS: For mutation screening, we combined autozygosity mapping and whole exome sequencing. Segregation of potential disease variants with the phenotype was verified by Sanger sequencing. A splice-site mutation was confirmed and quantified by qPCR. RESULTS: We found an autosomal recessive splice acceptor mutation in @entity7 ( @entity8 , @entity9 ) in all affected individuals, which led to exon skipping, and reduced the normal full-length mRNA copy number in the @entity0 to 5% of the wild-type level. Besides @entity4 and @entity6 , two of three affected siblings suffered from severe @entity3 . All @entity0 exhibited @entity5 of the limbs coinciding with symmetric T2 hyperintensities of the basal ganglia on cranial MRI. CONCLUSIONS: A recent report has shown dominant @entity7 mutations to occur de novo in @entity0 with @entity4 . Here, we demonstrate that a @entity7 -associated disorder can also be inherited as an autosomal recessive trait with heterozygous individuals being entirely healthy. Our findings expand the clinical and genetic spectrum of @entity7 mutations to comprise @entity3 and @entity1 .

title: Recessive @entity7 mutation associates with @entity6 , @entity4 , XXXX and @entity3 .

answer: @entity1


abstract: BACKGROUND: Various @entity2 cause @entity6 associated with @entity4 and @entity3 . Here, we set out to identify the @entity2 in a consanguineous Omani family with three affected @entity0 in whom mutations in known candidate genes had been excluded beforehand. METHODS: For mutation screening, we combined autozygosity mapping and whole exome sequencing. Segregation of potential disease variants with the phenotype was verified by Sanger sequencing. A splice-site mutation was confirmed and quantified by qPCR. RESULTS: We found an autosomal recessive splice acceptor mutation in @entity7 ( @entity8 , @entity9 ) in all affected individuals, which led to exon skipping, and reduced the normal full-length mRNA copy number in the @entity0 to 5% of the wild-type level. Besides @entity4 and @entity6 , two of three affected siblings suffered from severe @entity3 . All @entity0 exhibited @entity5 of the limbs coinciding with symmetric T2 hyperintensities of the basal ganglia on cranial MRI. CONCLUSIONS: A recent report has shown dominant @entity7 mutations to occur de novo in @entity0 with @entity4 . Here, we demonstrate that a @entity7 -associated disorder can also be inherited as an autosomal recessive trait with heterozygous individuals being entirely healthy. Our findings expand the clinical and genetic spectrum of @entity7 mutations to comprise @entity3 and @entity1 .

title: Recessive @entity7 mutation associates with XXXX , @entity4 , @entity1 and @entity3 .

answer: @entity6


abstract: BACKGROUND: Various @entity2 cause @entity6 associated with @entity4 and @entity3 . Here, we set out to identify the @entity2 in a consanguineous Omani family with three affected @entity0 in whom mutations in known candidate genes had been excluded beforehand. METHODS: For mutation screening, we combined autozygosity mapping and whole exome sequencing. Segregation of potential disease variants with the phenotype was verified by Sanger sequencing. A splice-site mutation was confirmed and quantified by qPCR. RESULTS: We found an autosomal recessive splice acceptor mutation in @entity7 ( @entity8 , @entity9 ) in all affected individuals, which led to exon skipping, and reduced the normal full-length mRNA copy number in the @entity0 to 5% of the wild-type level. Besides @entity4 and @entity6 , two of three affected siblings suffered from severe @entity3 . All @entity0 exhibited @entity5 of the limbs coinciding with symmetric T2 hyperintensities of the basal ganglia on cranial MRI. CONCLUSIONS: A recent report has shown dominant @entity7 mutations to occur de novo in @entity0 with @entity4 . Here, we demonstrate that a @entity7 -associated disorder can also be inherited as an autosomal recessive trait with heterozygous individuals being entirely healthy. Our findings expand the clinical and genetic spectrum of @entity7 mutations to comprise @entity3 and @entity1 .

title: Recessive XXXX mutation associates with @entity6 , @entity4 , @entity1 and @entity3 .

answer: @entity7


abstract: BACKGROUND: Various @entity2 cause @entity6 associated with @entity4 and @entity3 . Here, we set out to identify the @entity2 in a consanguineous Omani family with three affected @entity0 in whom mutations in known candidate genes had been excluded beforehand. METHODS: For mutation screening, we combined autozygosity mapping and whole exome sequencing. Segregation of potential disease variants with the phenotype was verified by Sanger sequencing. A splice-site mutation was confirmed and quantified by qPCR. RESULTS: We found an autosomal recessive splice acceptor mutation in @entity7 ( @entity8 , @entity9 ) in all affected individuals, which led to exon skipping, and reduced the normal full-length mRNA copy number in the @entity0 to 5% of the wild-type level. Besides @entity4 and @entity6 , two of three affected siblings suffered from severe @entity3 . All @entity0 exhibited @entity5 of the limbs coinciding with symmetric T2 hyperintensities of the basal ganglia on cranial MRI. CONCLUSIONS: A recent report has shown dominant @entity7 mutations to occur de novo in @entity0 with @entity4 . Here, we demonstrate that a @entity7 -associated disorder can also be inherited as an autosomal recessive trait with heterozygous individuals being entirely healthy. Our findings expand the clinical and genetic spectrum of @entity7 mutations to comprise @entity3 and @entity1 .

title: Recessive @entity7 mutation associates with @entity6 , XXXX , @entity1 and @entity3 .

answer: @entity4


abstract: BACKGROUND: Previous work has revealed sizeable deficits in the abilities of @entity0 with an @entity1 ( @entity1 ) to integrate auditory and visual speech signals, with clear implications for social communication in this population. There is a strong male preponderance in @entity1 , with approximately four affected males for every female. The presence of sex differences in @entity1 symptoms suggests a sexual dimorphism in the @entity1 phenotype, and raises the question of whether this dimorphism extends to @entity1 traits in the neurotypical population. Here, we investigated possible sexual dimorphism in multisensory speech integration in both @entity1 and neurotypical individuals. METHODS: We assessed whether males and females differed in their ability to benefit from visual speech when target words were presented under varying levels of signal-to-noise, in samples of neurotypical @entity0 and adults, and in @entity0 diagnosed with an @entity1 . RESULTS: In @entity2 ( @entity2 ) @entity0 and @entity0 with @entity1 , females (n = 47 and n = 15, respectively) were significantly superior in their ability to recognize words under audiovisual listening conditions compared to males (n = 55 and n = 58, respectively). This sex difference was absent in our sample of neurotypical adults (n = 28 females; n = 28 males). CONCLUSIONS: We propose that the development of audiovisual integration is delayed in male relative to female @entity0 , a delay that is also observed in @entity1 . In neurotypicals, these sex differences disappear in early adulthood when females approach their performance maximum and males "catch up." Our findings underline the importance of considering sex differences in the search for @entity3 endophenotypes and strongly encourage increased efforts to study the underrepresented population of females within @entity1 .

title: Sex differences in multisensory speech processing in both @entity2 @entity0 and those on the XXXX spectrum.

answer: @entity3


abstract: BACKGROUND: Previous work has revealed sizeable deficits in the abilities of @entity0 with an @entity1 ( @entity1 ) to integrate auditory and visual speech signals, with clear implications for social communication in this population. There is a strong male preponderance in @entity1 , with approximately four affected males for every female. The presence of sex differences in @entity1 symptoms suggests a sexual dimorphism in the @entity1 phenotype, and raises the question of whether this dimorphism extends to @entity1 traits in the neurotypical population. Here, we investigated possible sexual dimorphism in multisensory speech integration in both @entity1 and neurotypical individuals. METHODS: We assessed whether males and females differed in their ability to benefit from visual speech when target words were presented under varying levels of signal-to-noise, in samples of neurotypical @entity0 and adults, and in @entity0 diagnosed with an @entity1 . RESULTS: In @entity2 ( @entity2 ) @entity0 and @entity0 with @entity1 , females (n = 47 and n = 15, respectively) were significantly superior in their ability to recognize words under audiovisual listening conditions compared to males (n = 55 and n = 58, respectively). This sex difference was absent in our sample of neurotypical adults (n = 28 females; n = 28 males). CONCLUSIONS: We propose that the development of audiovisual integration is delayed in male relative to female @entity0 , a delay that is also observed in @entity1 . In neurotypicals, these sex differences disappear in early adulthood when females approach their performance maximum and males "catch up." Our findings underline the importance of considering sex differences in the search for @entity3 endophenotypes and strongly encourage increased efforts to study the underrepresented population of females within @entity1 .

title: Sex differences in multisensory speech processing in both XXXX @entity0 and those on the @entity3 spectrum.

answer: @entity2


abstract: BACKGROUND: Previous work has revealed sizeable deficits in the abilities of @entity0 with an @entity1 ( @entity1 ) to integrate auditory and visual speech signals, with clear implications for social communication in this population. There is a strong male preponderance in @entity1 , with approximately four affected males for every female. The presence of sex differences in @entity1 symptoms suggests a sexual dimorphism in the @entity1 phenotype, and raises the question of whether this dimorphism extends to @entity1 traits in the neurotypical population. Here, we investigated possible sexual dimorphism in multisensory speech integration in both @entity1 and neurotypical individuals. METHODS: We assessed whether males and females differed in their ability to benefit from visual speech when target words were presented under varying levels of signal-to-noise, in samples of neurotypical @entity0 and adults, and in @entity0 diagnosed with an @entity1 . RESULTS: In @entity2 ( @entity2 ) @entity0 and @entity0 with @entity1 , females (n = 47 and n = 15, respectively) were significantly superior in their ability to recognize words under audiovisual listening conditions compared to males (n = 55 and n = 58, respectively). This sex difference was absent in our sample of neurotypical adults (n = 28 females; n = 28 males). CONCLUSIONS: We propose that the development of audiovisual integration is delayed in male relative to female @entity0 , a delay that is also observed in @entity1 . In neurotypicals, these sex differences disappear in early adulthood when females approach their performance maximum and males "catch up." Our findings underline the importance of considering sex differences in the search for @entity3 endophenotypes and strongly encourage increased efforts to study the underrepresented population of females within @entity1 .

title: Sex differences in multisensory speech processing in both @entity2 XXXX and those on the @entity3 spectrum.

answer: @entity0


abstract: OBJECTIVE: Morphological changes of recent small subcortical @entity4 are not well defined. The purpose of the present study was to describe the MRI characteristics of the evolution for this @entity2 subtype. METHODS: We conducted a retrospective review of @entity0 diagnosed with definite supratentorial recent small subcortical @entity4 according to the ASCO classification with baseline and follow-up MRI (>= 90   days of @entity2 onset). We investigated the incidence of @entity6 formation, the @entity4 volume change, and the positional relationship between @entity5 and preexisting @entity1 ( @entity1 ) of presumed vascular origin. RESULTS: We identified 62 @entity0 with a median age of 71   years (range: 30-87). Median follow-up period was 26   months (range: 3-99). @entity6 formation was observed in 38 @entity5 (61%). Eighteen lesions (29%) were partially adjacent to @entity1 and 7 (11%) were fused into @entity1 . In a multiple logistic regression analysis, age [odds ratio per 5-year increase: 1.34; 95% confidence interval (CI): 1.03-1.80; p   =   0.03] and baseline @entity4 volume (odds ratio @entity3 -ml increase: 4.7; 95% CI: 1.6-19.7; p   =   0.003) were independent predictors of @entity6 formation. There was a significant volume reduction between baseline and follow-up @entity5 (median volume reduction rate: 44%). CONCLUSION: More than one-third of recent small subcortical @entity4 do not lead to @entity6 formation and 40% of @entity5 overlap with @entity1 . Our data indicate the continuity between recent small subcortical @entity4 and @entity1 .

title: MRI Characteristics of the Evolution of Supratentorial Recent Small Subcortical XXXX .

answer: @entity4


abstract: @entity1 in 16 lateral retinacula excised at the time of Insall proximal realignments or isolated lateral retinacular releases performed in @entity0 with symptomatic @entity4 was evaluated by means of conventional histology and immunohistochemical and morphometric analyses. A relationship between clinical and histologic findings was found. An increase in the proportion of innervated tissue was correlated with @entity4 . We found a significant relationship between total neural area and @entity2 . The group with moderate @entity2 had the highest number of nerves and the highest neural area. In reference to total neural area and @entity2 , there was a significant difference only between the @entity0 with moderate @entity2 and those with light @entity2 , but not between @entity0 with severe @entity2 and those with moderate @entity2 . The group with severe @entity2 also showed a high neural area, although with a lower number of nerves. The severe- @entity2 group had the largest nerves (24% of nerve fibers surpassing 25 microns diameter) in a zonal disposition, in which there were groups of nerve fibers in some fields and no nerve fibers in others. The group with moderate @entity2 had an increase in medium and small nerve fibers (mean diameter, 18 microns), predominantly of tiny perivascular fibers. Moreover, we believe that instability in @entity0 with @entity4 can be explained in part because of @entity3 due to @entity1 .

title: Quantitative analysis of nerve changes in the lateral retinaculum in @entity0 with isolated symptomatic XXXX . A preliminary study.

answer: @entity4


abstract: @entity1 in 16 lateral retinacula excised at the time of Insall proximal realignments or isolated lateral retinacular releases performed in @entity0 with symptomatic @entity4 was evaluated by means of conventional histology and immunohistochemical and morphometric analyses. A relationship between clinical and histologic findings was found. An increase in the proportion of innervated tissue was correlated with @entity4 . We found a significant relationship between total neural area and @entity2 . The group with moderate @entity2 had the highest number of nerves and the highest neural area. In reference to total neural area and @entity2 , there was a significant difference only between the @entity0 with moderate @entity2 and those with light @entity2 , but not between @entity0 with severe @entity2 and those with moderate @entity2 . The group with severe @entity2 also showed a high neural area, although with a lower number of nerves. The severe- @entity2 group had the largest nerves (24% of nerve fibers surpassing 25 microns diameter) in a zonal disposition, in which there were groups of nerve fibers in some fields and no nerve fibers in others. The group with moderate @entity2 had an increase in medium and small nerve fibers (mean diameter, 18 microns), predominantly of tiny perivascular fibers. Moreover, we believe that instability in @entity0 with @entity4 can be explained in part because of @entity3 due to @entity1 .

title: Quantitative analysis of nerve changes in the lateral retinaculum in XXXX with isolated symptomatic @entity4 . A preliminary study.

answer: @entity0


abstract: PURPOSE OF REVIEW: Inhibition of the renin-angiotensin system (RASi) lowers blood pressure, reduces cardiovascular outcomes and blunts the progressive course of @entity3 . This narrative article summarizes why the hypothesis came up that more complete RASi with two different agents should be more beneficial compared with one agent and how this hypothesis was deflated in randomized clinical trials (RCTs). RECENT FINDINGS: The hypothesis was based on experimental findings and surrogate endpoints in @entity0 , namely lowering of blood pressure and reduction of @entity5 . Three large RCTs in @entity0 with @entity7 or in @entity10 randomized almost 40000 @entity0 . RASi with one agent was compared with RASi with two agents. All three RCTs ruled out benefits of dual RASi on major cardiovascular outcomes and reported substantial adverse effects of dual RASi. The latter included @entity11 , @entity8 , symptomatic @entity4 and @entity9 . There was also no substantial advantage of dual over monotherapy on decline in kidney function. In one RCT, there was a hint of nonsustained, early benefit on kidney outcomes with dual therapy. SUMMARY: Outside @entity6 , RASi with two agents is not indicated to treat @entity2 because of substantial safety concerns and lack of benefit on major @entity1 .

title: Dual renin-angiotensin system blockade and outcome benefits in XXXX : a narrative review.

answer: @entity2


abstract: We examined the relationship between apoptosis and the progression of @entity0 @entity3 . Studies were conducted on a total of 88 surgically removed stomachs, comprising 26 minute (less than 5 mm in diameter), 29 early (limited to the mucosal and submucosal layer) and 33 advanced @entity2 . Apoptotic cells were visualized by @entity6 ( @entity6 )-mediated @entity5 -digoxigenin nick end labelling (TUNEL). Serial sections were immunostained for @entity4 and Ki-67. The mean apoptotic indices (AI: percentage of TUNEL signal positive cells) of minute, early, and advanced @entity2 were 4.1 +/- 0.6, 3.8 +/- 1.2, and 4.0 +/- 1.2 in 46 well differentiated @entity2 , and 2.1 +/- 0.5, 2.7 +/- 0.9, and 2.2 +/- 1.1 in 42 poorly differentiated @entity2 , respectively. Similarly, the mean Ki-67 labelling indices (KI) were 39.2 +/- 7.8, 47.2 +/- 12.8, 52.6 +/- 13.1 in the former, and 35.0 +/- 9.3, 36.9 +/- 10.3, and 40.0 +/- 9.2 in the latter, respectively. Both mean AI and mean KI were significantly higher in well differentiated than in poorly differentiated @entity2 (P < 0.05). However, the value of mean AI did not differ among minute, early, and advanced @entity2 in either histological type, while KI increased gradually with @entity1 progression. The frequency of nuclear @entity4 expression did not differ among the three categories, implying that the gene mutation is an early event in @entity3 . There was no statistical significance between nuclear @entity4 expression and mean AI. These results suggest that the progression of @entity3 is defined by a gradual increase of proliferative activity and constant occurrence of apoptosis and that naturally occurring apoptosis is induced predominantly via a @entity4 -gene-independent pathway.

title: Frequent occurrence of apoptosis is an early event in the oncogenesis of @entity0 XXXX .

answer: @entity3


abstract: We examined the relationship between apoptosis and the progression of @entity0 @entity3 . Studies were conducted on a total of 88 surgically removed stomachs, comprising 26 minute (less than 5 mm in diameter), 29 early (limited to the mucosal and submucosal layer) and 33 advanced @entity2 . Apoptotic cells were visualized by @entity6 ( @entity6 )-mediated @entity5 -digoxigenin nick end labelling (TUNEL). Serial sections were immunostained for @entity4 and Ki-67. The mean apoptotic indices (AI: percentage of TUNEL signal positive cells) of minute, early, and advanced @entity2 were 4.1 +/- 0.6, 3.8 +/- 1.2, and 4.0 +/- 1.2 in 46 well differentiated @entity2 , and 2.1 +/- 0.5, 2.7 +/- 0.9, and 2.2 +/- 1.1 in 42 poorly differentiated @entity2 , respectively. Similarly, the mean Ki-67 labelling indices (KI) were 39.2 +/- 7.8, 47.2 +/- 12.8, 52.6 +/- 13.1 in the former, and 35.0 +/- 9.3, 36.9 +/- 10.3, and 40.0 +/- 9.2 in the latter, respectively. Both mean AI and mean KI were significantly higher in well differentiated than in poorly differentiated @entity2 (P < 0.05). However, the value of mean AI did not differ among minute, early, and advanced @entity2 in either histological type, while KI increased gradually with @entity1 progression. The frequency of nuclear @entity4 expression did not differ among the three categories, implying that the gene mutation is an early event in @entity3 . There was no statistical significance between nuclear @entity4 expression and mean AI. These results suggest that the progression of @entity3 is defined by a gradual increase of proliferative activity and constant occurrence of apoptosis and that naturally occurring apoptosis is induced predominantly via a @entity4 -gene-independent pathway.

title: Frequent occurrence of apoptosis is an early event in the oncogenesis of XXXX @entity3 .

answer: @entity0


abstract: BACKGROUND: The @entity4 ) predisposes 500   000 @entity0 to @entity1 . Host genetic background may facilitate virus persistence in the uterine cervix. Polymorphisms in regulatory and coding regions of cytokine genes have been associated with susceptibility to some @entity0 diseases. AIM: This study aims at investigating whether @entity3 @entity8 and @entity7 @entity10 and @entity9 polymorphisms are associated with susceptibility to @entity5 /progression to @entity6 ( @entity6 ). SUBJECTS AND METHODS: One hundred and twenty-two HPV infected and 132 HPV negative @entity0 (the latter used as healthy controls) were analysed. @entity3 @entity8 and @entity7 ( @entity10 and @entity9 ) polymorphisms were analysed using specific sequence polymorphism PCR (SSP-PCR). Univariate statistical analysis and a logistic regression were performed. RESULTS: The @entity3 -308A allele was associated with susceptibility to @entity5 (p   =   0.0008), while the @entity7 -607A allele conferred protection against @entity5 (p   =   0.0043). @entity3 @entity8 and @entity7 ( @entity10 and @entity9 ) polymorphisms were not associated with development of @entity2 (p   >   0.05). An association was also observed between smoking and susceptibility to the development of @entity6 . CONCLUSION: The findings suggest an association between two @entity3 SNPs and susceptibility to @entity5 in @entity0 from Northeast Brazil. The results need to be functionally validated and replicated in other populations with different ethnic backgrounds.

title: Tumor necrosis factor (TNF) alpha and interleukin (IL) 18 genes polymorphisms are correlated with susceptibility to @entity5 in XXXX with and without cervical @entity2 .

answer: @entity0


abstract: BACKGROUND: The @entity4 ) predisposes 500   000 @entity0 to @entity1 . Host genetic background may facilitate virus persistence in the uterine cervix. Polymorphisms in regulatory and coding regions of cytokine genes have been associated with susceptibility to some @entity0 diseases. AIM: This study aims at investigating whether @entity3 @entity8 and @entity7 @entity10 and @entity9 polymorphisms are associated with susceptibility to @entity5 /progression to @entity6 ( @entity6 ). SUBJECTS AND METHODS: One hundred and twenty-two HPV infected and 132 HPV negative @entity0 (the latter used as healthy controls) were analysed. @entity3 @entity8 and @entity7 ( @entity10 and @entity9 ) polymorphisms were analysed using specific sequence polymorphism PCR (SSP-PCR). Univariate statistical analysis and a logistic regression were performed. RESULTS: The @entity3 -308A allele was associated with susceptibility to @entity5 (p   =   0.0008), while the @entity7 -607A allele conferred protection against @entity5 (p   =   0.0043). @entity3 @entity8 and @entity7 ( @entity10 and @entity9 ) polymorphisms were not associated with development of @entity2 (p   >   0.05). An association was also observed between smoking and susceptibility to the development of @entity6 . CONCLUSION: The findings suggest an association between two @entity3 SNPs and susceptibility to @entity5 in @entity0 from Northeast Brazil. The results need to be functionally validated and replicated in other populations with different ethnic backgrounds.

title: Tumor necrosis factor (TNF) alpha and interleukin (IL) 18 genes polymorphisms are correlated with susceptibility to XXXX in @entity0 with and without cervical @entity2 .

answer: @entity5


abstract: BACKGROUND: The @entity4 ) predisposes 500   000 @entity0 to @entity1 . Host genetic background may facilitate virus persistence in the uterine cervix. Polymorphisms in regulatory and coding regions of cytokine genes have been associated with susceptibility to some @entity0 diseases. AIM: This study aims at investigating whether @entity3 @entity8 and @entity7 @entity10 and @entity9 polymorphisms are associated with susceptibility to @entity5 /progression to @entity6 ( @entity6 ). SUBJECTS AND METHODS: One hundred and twenty-two HPV infected and 132 HPV negative @entity0 (the latter used as healthy controls) were analysed. @entity3 @entity8 and @entity7 ( @entity10 and @entity9 ) polymorphisms were analysed using specific sequence polymorphism PCR (SSP-PCR). Univariate statistical analysis and a logistic regression were performed. RESULTS: The @entity3 -308A allele was associated with susceptibility to @entity5 (p   =   0.0008), while the @entity7 -607A allele conferred protection against @entity5 (p   =   0.0043). @entity3 @entity8 and @entity7 ( @entity10 and @entity9 ) polymorphisms were not associated with development of @entity2 (p   >   0.05). An association was also observed between smoking and susceptibility to the development of @entity6 . CONCLUSION: The findings suggest an association between two @entity3 SNPs and susceptibility to @entity5 in @entity0 from Northeast Brazil. The results need to be functionally validated and replicated in other populations with different ethnic backgrounds.

title: Tumor necrosis factor (TNF) alpha and interleukin (IL) 18 genes polymorphisms are correlated with susceptibility to @entity5 in @entity0 with and without cervical XXXX .

answer: @entity2


abstract: STATEMENT OF PROBLEM: Ceramic restorations are frequently being placed due to the esthetic demand and the cost of noble metals that has increased considerably. One major disadvantage of ceramic restoration is failure of the material due to @entity0 by crack propagation. In  vitro studies are of little clinical significance and in  vivo studies are too short to support clinical success. PURPOSE: The purpose of this retrospective study was to evaluate the failure rate of @entity1 disilicate restorations (monolithic and layered) at 4 years. MATERIAL AND METHODS: Data were collected over 45 months from 2 commercial laboratories. Restorations were categorized into monolithic restorations and layered restorations. Each category was further classified into complete coverage single crowns, fixed dental prostheses, e.max veneers, and inlay/onlay restorations. Failure rates were compared and analyzed using Chi-square (a=.05). RESULTS: A total of 21   340 restorations were evaluated in this study and included 15   802 monolithic restorations and 5538 layered restorations. The failure rate for single crown monolithic restorations was 0.91% and was 1.83% for single crown layered restorations. For fixed dental prostheses, 4.55% of monolithic restorations failed. For e.max veneers, 1.3% of monolithic veneers fractured and 1.53% of layered veneers fractured. Of the inlay/onlay restorations group, 1.01% of monolithic restorations fractured. CONCLUSION: In the short term (45 months), restorations fabricated with the @entity1 disilicate material ( @entity2 e.max) had relatively low @entity0 rates. Layered single crowns fractured at approximately 2 times the rate of monolithic crowns.

title: Survival rate of XXXX disilicate restorations at 4 years: A retrospective study.

answer: @entity1


abstract: PURPOSE: The purposes of this study is first, to investigate intensive care @entity0 ' perceptions of stressors; second, to investigate the health care provider's perception of what constitutes a stressor from the @entity0 's perspective; and third, to describe how health care providers manage their @entity0 ' stressors. This was a mixed-methods study; the quantitative section replicated Cornock's 1998 study of stress in the @entity3 ( @entity3 ), with difference in sampling to include all health care providers in the @entity3 , in addition to nurses. The qualitative section added information to the current literature by describing how health care providers manage their @entity0 's stressors. This article reports the quantitative findings of this study, as the qualitative section is presented in a separate article. BACKGROUND AND SIGNIFICANCE: It is important to describe @entity3 @entity0 ' stressful experiences to assess @entity0 's stressors, provide holistic care to eliminate stressors, and provide feedback to health care providers. There is a need to describe the clinical practice related to stress perception and management of stressors in the critical care environment. METHODOLOGY: A mixed-methods comparative descriptive design was used for the quantitative section, and a phenomenological approach guided the qualitative section. Lazarus and Folkman's theory formed the bases for integrating all variables investigated in this study. The sample included 70 @entity3 @entity0 and 70 @entity3 health care providers. After consenting to participate in this study, subjects were given a demographic form and a paper-based tool, the Environmental Stressors graphic data form Questionnaire. Questionnaires were filled out by subjects anonymously in the @entity3 and returned to the researcher in the same setting. FINDINGS: Descriptive statistics were analyzed using SPSS data analysis software. The top 3 most stressful items ranked by the @entity0 included "being in @entity2 ," followed by "not being @entity1 "; on the other hand, health care providers perceived "being in @entity2 " followed by "not being able to communicate" and "not being in control of yourself" as the top 3 stressors perceived by their @entity0 . IMPLICATIONS FOR PRACTICE: The findings of this study are crucial and may inform nursing assessments and care of the @entity3 @entity0 . In addition, this information may encourage the @entity3 staff to manipulate and redesign the @entity3 environment to be less stressful. Also, the findings of this study guided the development of an @entity3 stressor control policy.

title: XXXX ' and Health Care Providers' Perception of Stressors in the Intensive Care Units.

answer: @entity0


abstract: PURPOSE: To define optimal planning target volume ( @entity2 ) margins for intensity modulated radiotherapy (IMRT)      knee-heel support (KHS) in @entity0 treated with adjuvant radiotherapy. METHODS: Computed tomography (CT) scans      KHS of 10 @entity0 were taken before and at 3rd and 5th week of treatment, fused and compared with initial IMRT plans. RESULTS: A @entity2 margin of 15  mm in anteroposterior (AP) and superoinferior (SI) directions and 5  mm in lateral directions were found to be adequate without any difference between      KHS except for the SI shifts in CTV-primary at the 3rd week. Five mm margin for iliac CTV was found to be inadequate in 10-20% of @entity0 in SI directions however when 7  mm margin was given for iliac @entity2 , it was found to be adequate. For presacral CTV, it was found that the most striking shift of the target volume was in the direction of AP. KHS caused significantly less volume of rectum and bladder in the treated volume. CONCLUSIONS: @entity2 margin of 15  mm in SI and AP, and 5  mm in lateral directions for CTV-primary were found to be adequate. A minimum of 7  mm @entity2 margin should be given to iliac CTV. The remarkable shifting in presacral CTV was believed to be due to the unforeseen hip malposition of @entity1 @entity0 . The KHS seems not to provide additional beneficial effect in decreasing the shifts both in CTV-primary and lymphatic, however it may have a beneficial effect of decreasing the OAR volume in @entity2 margins.

title: Determination of optimal planning target volume margins in XXXX with gynecological cancer.

answer: @entity0


abstract: @entity8 is characterized by reduced cardiac contractility due to direct changes in heart muscle function independent of @entity5 . An important contributor to @entity4 in the @entity0 state is an impaired sarcoplasmic reticulum (SR) function, leading to disturbed intracellular @entity6 handling. We investigated whether overexpression of the SR @entity6 pump ( @entity9 ) in @entity1 could reduce the impact of @entity0 on the development of @entity3 . @entity0 was induced by @entity7 injection (200 mg/kg), and left ventricular (LV) function was analyzed in isolated hearts 3 weeks later. In @entity0 hearts systolic LV pressure was decreased by 15% and maximum speed of relaxation (-dP/dt) by 34%. Functional changes were also assessed in isolated papillary muscles. Active force was reduced by 61% and maximum speed of relaxation by 65% in the @entity0 state. The contractile impairment was accompanied by a 30% decrease in @entity9 protein in @entity0 @entity1 . We investigated whether increased @entity9 expression in transgenic @entity9 -overexpressing @entity1 could compensate for the @entity0 -induced decrease in cardiac function. Under normal conditions, @entity9 overexpressors show improved contractile performance relative to @entity2 ( @entity2 ) @entity1 (-dP/dt: 3,169 vs. 2,559 mmHg/s, respectively). Measurement of LV function in hearts from @entity0 @entity9 @entity1 revealed systolic and diastolic functions that were similar to @entity2 control @entity1 and markedly improved relative to @entity0 @entity2 @entity1 (-dP/dt: 2,534 vs. 1,690 mmHg/s in @entity0 @entity9 vs. @entity0 @entity2 @entity1 , respectively). Similarly, the contractile behavior of isolated papillary muscles from @entity0 @entity9 @entity1 was not different from that of control @entity1 . @entity9 protein expression was higher (60%) in @entity0 @entity9 @entity1 than @entity2 @entity0 @entity1 . These results indicate that overexpression of @entity9 can protect @entity0 hearts from severe @entity4 , presumably by improving the @entity6 sequestration of the SR.

title: Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in XXXX .

answer: @entity8


abstract: Reproductive effects of 1,3 @entity3 inhalation have been evaluated in male @entity0 by reduction of post-meiotic germ cells, alteration of sperm chromatin structure and transmission of chromosome aberrations to one-cell embryos. Animals were exposed for 5 consecutive days for 6 h per day to @entity3 concentrations of 130, 500 or 1300 ppm. The testicular fraction of post-meiotic germ cells was measured by flow cytometric analysis on the basis of their DNA content. Round spermatids were discriminated from mature, elongated spermatids by their different degree of chromatin condensation. @entity3 -induced cytotoxic effects on differentiating spermatogonia were shown by a concentration-dependent decrease of round spermatids occurring 21 days after chemical exposure, confirmed by a similar decrease of elongated spermatids measured in testes sampled 7 days later. Statistically significant effects were seen already at 130 ppm. An incomplete repopulation of the elongated spermatid compartment observed 35 days after exposure to 1300 ppm suggested that, at the highest concentration tested, @entity3 @entity1 extended to stem cells. Alterations of sperm chromatin were revealed by its increased sensitivity to acidic denaturation in situ. The percentage of abnormal sperm was significantly increased after @entity3 exposure of differentiating spermatogonia and spermatocytes. This suggested the induction of persistent effects interfering with chromatin remodelling during spermiogenesis. Chromosome-type structural aberrations were significantly elevated in first-cleavage embryos conceived by males mated during the first and second week after the end of exposure. The lowest effective tested concentration was 500 ppm, the same reported for dominant lethal induction under identical exposure conditions. As in the dominant lethal assay, the effect of this dose was confined to exposed sperm, while both sperm and late spermatids were affected by the inhalation of 1300 ppm. A quantitative comparison between the effects induced by intraperitoneal injections of @entity2 or @entity3 inhalations suggested that other reactive intermediates, in addition to @entity2 , might contribute to mediate @entity3 -induced reproductive @entity1 .

title: Reproductive XXXX of 1,3-butadiene in the @entity0 : cytogenetic analysis of chromosome aberrations in first-cleavage embryos and flow cytometric evaluation of spermatogonial cell killing.

answer: @entity1


abstract: Reproductive effects of 1,3 @entity3 inhalation have been evaluated in male @entity0 by reduction of post-meiotic germ cells, alteration of sperm chromatin structure and transmission of chromosome aberrations to one-cell embryos. Animals were exposed for 5 consecutive days for 6 h per day to @entity3 concentrations of 130, 500 or 1300 ppm. The testicular fraction of post-meiotic germ cells was measured by flow cytometric analysis on the basis of their DNA content. Round spermatids were discriminated from mature, elongated spermatids by their different degree of chromatin condensation. @entity3 -induced cytotoxic effects on differentiating spermatogonia were shown by a concentration-dependent decrease of round spermatids occurring 21 days after chemical exposure, confirmed by a similar decrease of elongated spermatids measured in testes sampled 7 days later. Statistically significant effects were seen already at 130 ppm. An incomplete repopulation of the elongated spermatid compartment observed 35 days after exposure to 1300 ppm suggested that, at the highest concentration tested, @entity3 @entity1 extended to stem cells. Alterations of sperm chromatin were revealed by its increased sensitivity to acidic denaturation in situ. The percentage of abnormal sperm was significantly increased after @entity3 exposure of differentiating spermatogonia and spermatocytes. This suggested the induction of persistent effects interfering with chromatin remodelling during spermiogenesis. Chromosome-type structural aberrations were significantly elevated in first-cleavage embryos conceived by males mated during the first and second week after the end of exposure. The lowest effective tested concentration was 500 ppm, the same reported for dominant lethal induction under identical exposure conditions. As in the dominant lethal assay, the effect of this dose was confined to exposed sperm, while both sperm and late spermatids were affected by the inhalation of 1300 ppm. A quantitative comparison between the effects induced by intraperitoneal injections of @entity2 or @entity3 inhalations suggested that other reactive intermediates, in addition to @entity2 , might contribute to mediate @entity3 -induced reproductive @entity1 .

title: Reproductive @entity1 of 1,3-butadiene in the XXXX : cytogenetic analysis of chromosome aberrations in first-cleavage embryos and flow cytometric evaluation of spermatogonial cell killing.

answer: @entity0


abstract: OBJECTIVE: The concept of therapeutic angiogenesis with @entity6 ( @entity6 ) has been validated in peripheral @entity2 . Its use in @entity4 may be delayed as the result of the description in a porcine model of peripheral vasodilation after intraluminal injections of @entity6 resulting in a 50% fatality rate by @entity3 . We carried out this study to test whether @entity6 -induced @entity3 (1) is species specific, (2) is mediated by the receptor mediating angiogenesis, (3) is prevented by inhibition of @entity5 synthase. METHODS: In the @entity1 corneal pocket assay we tested whether a previously published anti-idiotypic antibody (AIA) agonist of the @entity6 receptor @entity7 / @entity8 could elicit angiogenesis. Various doses of recombinant @entity6 or AIA were injected into anesthetized normotensive @entity0 -Kyoto @entity0 and the mean arterial blood pressure (MABP) was recorded. To test the implication of @entity5 in @entity6 -induced @entity3 we treated the animals with a competitive inhibitor of @entity5 synthase prior to the injection of @entity6 . RESULTS: Both @entity6 and AIA induce angiogenesis but only intravenous injections of @entity6 induced a rapid, transient and dose-dependent decrease in MABP. The ED50 was 0.5 micrograms. The interval between two @entity6 injections required to lead to a decrease of MABP was 40 minutes. @entity5 synthesis inhibitor prevented, in a reversible fashion, the effect of @entity6 . CONCLUSION: @entity6 -induced @entity3 is not species specific. It is prevented by @entity5 inhibition. @entity6 -induced angiogenesis and @entity3 are not mediated in vivo by the same @entity6 receptor.

title: Activation of XXXX / @entity7 mediates angiogenesis but not @entity3 .

answer: @entity7


abstract: OBJECTIVE: The concept of therapeutic angiogenesis with @entity6 ( @entity6 ) has been validated in peripheral @entity2 . Its use in @entity4 may be delayed as the result of the description in a porcine model of peripheral vasodilation after intraluminal injections of @entity6 resulting in a 50% fatality rate by @entity3 . We carried out this study to test whether @entity6 -induced @entity3 (1) is species specific, (2) is mediated by the receptor mediating angiogenesis, (3) is prevented by inhibition of @entity5 synthase. METHODS: In the @entity1 corneal pocket assay we tested whether a previously published anti-idiotypic antibody (AIA) agonist of the @entity6 receptor @entity7 / @entity8 could elicit angiogenesis. Various doses of recombinant @entity6 or AIA were injected into anesthetized normotensive @entity0 -Kyoto @entity0 and the mean arterial blood pressure (MABP) was recorded. To test the implication of @entity5 in @entity6 -induced @entity3 we treated the animals with a competitive inhibitor of @entity5 synthase prior to the injection of @entity6 . RESULTS: Both @entity6 and AIA induce angiogenesis but only intravenous injections of @entity6 induced a rapid, transient and dose-dependent decrease in MABP. The ED50 was 0.5 micrograms. The interval between two @entity6 injections required to lead to a decrease of MABP was 40 minutes. @entity5 synthesis inhibitor prevented, in a reversible fashion, the effect of @entity6 . CONCLUSION: @entity6 -induced @entity3 is not species specific. It is prevented by @entity5 inhibition. @entity6 -induced angiogenesis and @entity3 are not mediated in vivo by the same @entity6 receptor.

title: Activation of @entity7 / XXXX mediates angiogenesis but not @entity3 .

answer: @entity7


abstract: OBJECTIVE: The concept of therapeutic angiogenesis with @entity6 ( @entity6 ) has been validated in peripheral @entity2 . Its use in @entity4 may be delayed as the result of the description in a porcine model of peripheral vasodilation after intraluminal injections of @entity6 resulting in a 50% fatality rate by @entity3 . We carried out this study to test whether @entity6 -induced @entity3 (1) is species specific, (2) is mediated by the receptor mediating angiogenesis, (3) is prevented by inhibition of @entity5 synthase. METHODS: In the @entity1 corneal pocket assay we tested whether a previously published anti-idiotypic antibody (AIA) agonist of the @entity6 receptor @entity7 / @entity8 could elicit angiogenesis. Various doses of recombinant @entity6 or AIA were injected into anesthetized normotensive @entity0 -Kyoto @entity0 and the mean arterial blood pressure (MABP) was recorded. To test the implication of @entity5 in @entity6 -induced @entity3 we treated the animals with a competitive inhibitor of @entity5 synthase prior to the injection of @entity6 . RESULTS: Both @entity6 and AIA induce angiogenesis but only intravenous injections of @entity6 induced a rapid, transient and dose-dependent decrease in MABP. The ED50 was 0.5 micrograms. The interval between two @entity6 injections required to lead to a decrease of MABP was 40 minutes. @entity5 synthesis inhibitor prevented, in a reversible fashion, the effect of @entity6 . CONCLUSION: @entity6 -induced @entity3 is not species specific. It is prevented by @entity5 inhibition. @entity6 -induced angiogenesis and @entity3 are not mediated in vivo by the same @entity6 receptor.

title: Activation of @entity7 / @entity7 mediates angiogenesis but not XXXX .

answer: @entity3


abstract: UNASSIGNED: Skin transplantation is a commonly used surgical technique; however, the complication rate, including @entity4 and delayed wound @entity7 due to inefficient perfusion, is significantly higher in @entity0 suffering from comorbidities. Hence, a subsequent repeat procedure is often necessary. In this report, two case studies are presented in which an @entity10 -based antiseptic is used with a @entity9 ( @entity9 ) instead of @entity8 ( @entity8 ), following a split-thickness skin graft. The two @entity0 selected were deemed to be at high risk of @entity3 due to comorbidities. The first @entity0 , a confirmed smoker with @entity1 , presented with a @entity6 that was resected and covered with a split-thickness skin graft. After 5 days of negative pressure wound therapy as a @entity9 , in combination with @entity8 , the graft became @entity2 . A second split-thickness skin graft was performed and an antiseptic regimen with @entity10 in combination with the same @entity9 resulted in a completely healed transplant. The second @entity0 , also a confirmed smoker with @entity1 and receiving oral @entity5 treatment, was diagnosed with a @entity2 on her leg. Following the split-thickness skin graft, @entity10 and @entity9 were applied. The @entity0 's skin graft completely healed without any adverse events. These two case studies indicate that the combination of @entity10 and @entity9 following split-thickness skin transplantation is safe, well-tolerated and appears to have positive benefits in the reconstruction of defects in @entity0 with @entity3 .

title: Outcomes for split-thickness skin transplantation in high-risk @entity0 using XXXX .

answer: @entity10


abstract: UNASSIGNED: Skin transplantation is a commonly used surgical technique; however, the complication rate, including @entity4 and delayed wound @entity7 due to inefficient perfusion, is significantly higher in @entity0 suffering from comorbidities. Hence, a subsequent repeat procedure is often necessary. In this report, two case studies are presented in which an @entity10 -based antiseptic is used with a @entity9 ( @entity9 ) instead of @entity8 ( @entity8 ), following a split-thickness skin graft. The two @entity0 selected were deemed to be at high risk of @entity3 due to comorbidities. The first @entity0 , a confirmed smoker with @entity1 , presented with a @entity6 that was resected and covered with a split-thickness skin graft. After 5 days of negative pressure wound therapy as a @entity9 , in combination with @entity8 , the graft became @entity2 . A second split-thickness skin graft was performed and an antiseptic regimen with @entity10 in combination with the same @entity9 resulted in a completely healed transplant. The second @entity0 , also a confirmed smoker with @entity1 and receiving oral @entity5 treatment, was diagnosed with a @entity2 on her leg. Following the split-thickness skin graft, @entity10 and @entity9 were applied. The @entity0 's skin graft completely healed without any adverse events. These two case studies indicate that the combination of @entity10 and @entity9 following split-thickness skin transplantation is safe, well-tolerated and appears to have positive benefits in the reconstruction of defects in @entity0 with @entity3 .

title: Outcomes for split-thickness skin transplantation in high-risk XXXX using @entity10 .

answer: @entity0


abstract: CONTEXT: @entity2 remains a leading cause of childhood morbidity. OBJECTIVE: Because prior reviews have focused on isolated symptoms and studies conducted in developing countries, this study focused on interventions commonly considered for use in developed countries. Intervention specific, @entity0 -centered outcomes were selected. DATA SOURCES: MEDLINE, EMBASE, the Cochrane Database of Systematic Reviews, trial registries, grey literature, and scientific meetings. STUDY SELECTION: Randomized controlled trials, conducted in developed countries, of @entity0 aged <18 years, with @entity2 , performed in emergency department or outpatient settings which evaluated oral rehydration therapy (ORT), antiemetics, probiotics or intravenous fluid administration rate. DATA EXTRACTION: The study was conducted in accordance with the Cochrane Handbook for Systematic Reviews of Interventions and the PRISMA guidelines. Data were independently extracted by multiple investigators. Analyses employed random effects models. RESULTS: 31 trials (4,444 @entity0 ) were included. ORT: Compared with intravenous rehydration, hospitalization (RR 0.80, 95%CI 0.24, 2.71) and emergency department return visits (RR 0.86, 95%CI 0.39, 1.89) were similar. Antiemetics: Fewer @entity0 administered an antiemetic required intravenous rehydration (RR 0.40, 95%CI 0.26, 0.60) While the data could not be meta-analyzed, three studies reported that @entity3 administration does increase the frequency of @entity1 . Probiotics: No studies reported on the primary outcome, three studies evaluated hospitalization within 7 days (RR 0.87, 95%CI 0.25, 2.98). Rehydration: No difference in length of stay was identified for rapid vs. standard intravenous or nasogastric rehydration. A single study found that 5% dextrose in normal saline reduced hospitalizations compared with normal saline alone (RR 0.70, 95% CI 0.53, 0.92). CONCLUSIONS: There is a paucity of @entity0 -centered outcome evidence to support many interventions. Since ORT is a low-cost, non-invasive intervention, it should continue to be used. Routine probiotic use cannot be endorsed at this time in outpatient @entity0 with @entity2 . Despite some evidence that ondansetron administration increases @entity1 frequency, emergency department use leads to reductions in intravenous rehydration and hospitalization. No benefits were associated with ondansetron use following emergency department discharge.

title: XXXX Therapies in Developed Countries: Systematic Review and Meta-Analysis.

answer: @entity2


abstract: @entity10 is a distinct clinical entity that differs from other pulmonary symptoms such as @entity3 , @entity2 , or @entity2 by various infectious agents. Recent research has supported the mechanism of cellular interaction between lung parenchymal cells and circulating immune cells mediated through a variety of cytokines including proinflammatory cytokines, chemokines, adhesion molecules, and profibrotic cytokines. Identifying reliable biomarkers for @entity10 will allow us to identify individuals at risk for @entity2 before or during the early stage of therapy. Prospective blood sampling, scoring of respiratory symptoms, and chest imaging were conducted for @entity0 receiving thoracic radiotherapy for @entity1 . Serial plasma specimens were analyzed for circulating cytokine changes before, during, and up to 12 weeks after radiation. @entity10 was diagnosed using National @entity1 Institute (NCI) common @entity4 criteria. Cytokine analysis was assayed for @entity8 ( @entity8 ), @entity6 ( @entity6 ), @entity12 ( @entity12 ), @entity13 , @entity9 , @entity11 ( @entity11 ), and @entity5 ( @entity5 ) using enzyme linked immmunosorbant assay (ELISA). Twenty-four @entity0 had clinical follow-up longer than 12 months after radiotherapy. Thirteen had symptomatic @entity2 (NCI grade 2). The peak incidence of symptoms was between 6 and 13 weeks after radiotherapy. Six @entity0 had only radiographic infiltrates (NCI grade 1). Five @entity0 did not have clinical or radiographic @entity2 . Both @entity8 and @entity6 levels were significantly higher before, during, and after radiotherapy for those who had @entity2 . The pattern of changes of @entity12 , @entity13 , @entity9 , @entity11 , and @entity5 varied, but none of these cytokines correlated with @entity10 . Analysis of a panel of circulating cytokines with different putative functions in radiation @entity7 identified @entity8 and @entity6 as early circulating cytokine markers for @entity10 .

title: XXXX and early circulatory cytokine markers.

answer: @entity10


abstract: OBJECTIVES: Electroconvulsive therapy (ECT) has @entity1 when carried out with muscle relaxants under general anesthesia. However, @entity4 quality can be affected by the depth of anesthesia and choice of anesthetic agent. The purpose of this study was to describe a general anesthetic technique for ECT by using laryngeal mask, bispectral index (BIS), and muscle relaxant monitoring. METHODS: Twenty-one @entity0 , between ages 18 and 70 years (American Society of Anesthesiologists physical status I-III), who underwent a total of 89 sessions of ECT were examined in a retrospective study. Anesthesia was induced by use of @entity10 (1.0 mg/kg) followed by @entity11 (0.2 mg/kg). The BIS, train-of-four, and end-tidal @entity5 were all monitored continuously. A laryngeal mask airway was used to maintain and protect the airway during the procedure. Electroconvulsive therapy stimuli were applied bilaterally when the train-of-four was assessed as being zero and BIS scores were 70. All @entity0 then received 5  g @entity6 and 2 mg @entity9 , while titrated to maintain the BIS value at 40 to 50, before the muscle relaxation exhibited complete recovery. RESULTS: The mean duration of treatment process takes approximately 82.5 minutes. Mean (SD) @entity4 length was 58.8 (28.3) seconds, with 4.5% incidence of restimulation per treatment. Incidence of awareness was 0%. No @entity0 exhibited @entity8 , @entity2 , @entity3 , or @entity7 in the postseizure phase. CONCLUSIONS: Bispectral index monitoring of the depth of anesthesia may have improved @entity4 quality, and awareness did not occur.

title: Electroconvulsive Therapy Under General Anesthesia With XXXX , Laryngeal Mask Airways, and Bispectral Index.

answer: @entity11


abstract: The incidence of @entity1 in the general population is difficult to estimate. Certain cysts are functional and generally not operated, except in case of complications. Others are organic cysts which are usually, but not always operated. Data is available only from surgical series or pathology reports. An analysis of the literature shows that for operated cysts, approximately 75% are organic, 25% are function and 1 to 4% of the supposed benign cysts are found to be malignant. In France, the PMSI database on public and private institutions is available on the net (www.le-pmsi.fr). The number of hospital stays for @entity2 or @entity1 was to the order of 45,000 in 1998 and 1999. Twenty-one percent of these @entity0 were discharged without surgery. Most had a functional @entity2 . This leaves 32,000 @entity0 who underwent surgery annually for an @entity1 . Nearly 7000 @entity0 were hospitalized for follicular or yellow body cysts, i.e. 15%, with an incidence of 29/100,000 @entity0 over the age of 15 years. The abstention rate for hospitalized @entity0 with a follicular cyst or a yellow body cyst was 30 to 40%. For @entity3 , there were 5218 hospitalizations in 1999 (2137 in the public hospitals and 3081 in private clinics) (11% of the hospitalizations). The rate of abstention was 11% (15% in the public hospitals and 8% in private clinics). Approximately 4100 @entity0 thus underwent surgery, including 13% for @entity1 . According to data in the literature, serous and mucinous cysts account for 20 to 30% of the operated cysts and @entity4 for 10 to 20%. The type of cyst cannot be identified with the international WHO classification used in the PMSI.

title: [Epidemiology of apparently benign XXXX ].

answer: @entity1


abstract: Social support in couples often occurs during conversations and is an important predictor of positive outcomes in @entity1 with @entity0 . Even though talking about @entity2 may be upsetting, vocally expressed emotional arousal and its association with social support have not been examined. The goal of this study was to examine the role of vocally encoded emotional arousal and social support behaviors in 129 German and American couples, assessed at baseline of clinical trials for @entity1 with @entity0 and their male partners. Range of fundamental frequency was used as a measure of expressed emotional arousal during videotaped interactions in which the @entity1 shared @entity2 -related concerns. Social support behaviors were assessed as specific social support behaviors at the talk-turn level (positive, neutral, and negative) and broader communication behaviors also relevant to social support at the global level (depth and articulation, caring, quality of communication) using the Social Support Interaction Coding System (Bradbury _ Pasch, 1994). Data were analyzed using actor-partner interdependence models. @entity1 displayed more positive, fewer neutral support-receiving behaviors, and greater depth and articulation if their own emotional arousal was higher. @entity1 also displayed more neutral and (at the trend level) fewer positive support-receiving behaviors if their partners' emotional arousal was higher. @entity1 's behaviors were not associated with their own or @entity1 's emotional arousal. Results indicate that it may be adaptive for @entity1 with @entity2 to openly experience their distress during social support conversations with their partners; high emotional arousal of the partners may interfere with this process.

title: Emotional arousal predicts observed social support in German and American couples talking about XXXX .

answer: @entity0


abstract: UNASSIGNED: The recently extinct (ca. 1768) Steller's sea @entity0 (Hydrodamalis gigas) was a large, edentulous North Pacific sirenian. The phylogenetic affinities of this taxon to other members of this clade, living and extinct, are uncertain based on previous morphological and molecular studies. We employed hybridization capture methods and second generation sequencing technology to obtain >30kb of exon sequences from 26 nuclear genes for both H. gigas and @entity3 . We also obtained complete coding sequences for the tooth-related enamelin (ENAM) gene. Hybridization probes designed using @entity3 and manatee sequences were both highly effective in retrieving sequences from H. gigas (mean=98.8% coverage), as were more divergent probes for regions of ENAM (99.0% coverage) that were designed exclusively from a proboscidean (African @entity1 ) and a hyracoid ( @entity4 ). New sequences were combined with available sequences for representatives of all other afrotherian orders. We also expanded a previously published morphological matrix for living and fossil Sirenia by adding both new taxa and nine new postcranial characters. Maximum likelihood and parsimony analyses of the molecular data provide robust support for an association of H. gigas and @entity3 to the exclusion of living trichechids (manatees). Parsimony analyses of the morphological data also support the inclusion of H. gigas in Dugongidae with @entity3 and fossil dugongids. Timetree analyses based on calibration density approaches with hard- and soft-bounded constraints suggest that H. gigas and @entity3 diverged in the Oligocene and that crown sirenians last shared a common ancestor in the Eocene. The coding sequence for the ENAM gene in H. gigas does not contain frameshift mutations or stop codons, but there is a transversion mutation (AG to CG) in the acceptor splice site of intron 2. This disruption in the edentulous Steller's sea @entity0 is consistent with previous studies that have documented inactivating mutations in tooth-specific loci of a variety of edentulous and enamelless vertebrates including birds, turtles, @entity2 , pangolins, xenarthrans, and baleen whales. Further, branch-site dN/dS analyses provide evidence for positive selection in ENAM on the stem dugongid branch where extensive tooth reduction occurred, followed by neutral evolution on the Hydrodamalis branch. Finally, we present a synthetic evolutionary tree for living and fossil sirenians showing several key innovations in the history of this clade including character state changes that parallel those that occurred in the evolutionary history of cetaceans.

title: Interordinal gene capture, the phylogenetic position of Steller's sea XXXX based on molecular and morphological data, and the macroevolutionary history of Sirenia.

answer: @entity0


abstract: UNASSIGNED: Biochar has sorption capacity, and can be used to enhance the sequestration of volatile organic contaminants such as pesticides in soil. @entity2 ( @entity0 ) is an important soil fumigant for the production of many fruit and vegetable crops, but its emissions must be minimized to reduce exposure risks and air pollution. The objective of this study was to determine the capacity of biochar to adsorb @entity0 and the effect of biochar amendments to soil on @entity0 emission, concentration in the soil gas phase, degradation in soil and @entity0 bioactivity for controlling soil borne pests. @entity0 emission and concentration in the soil air phase were measured from packed soil columns after fumigant injection at 20-cm depth and application of selected doses of biocharto the surface 5 cm soil. Laboratory incubation and fumigation experiments were conducted to determine the capacity of biochar to adsorb @entity0 , the effects on @entity0 degradation and, separately, @entity0 's bioactivity on soil borne pests in soil amended with biochar. Biochar amendment at 2% to 5% (w/w) greatly reduced total @entity0 emission losses by 85.7% - 97.7% compared to fumigation without biochar. @entity0 concentrations in the soil gas-phase, especially in the top 5 cm of soil, were reduced within 48 h following application. The half-life of @entity0 decreased from 13.6 h to 6.4 h as the biochar rate increased from 0% to 5%. @entity0 and its metabolite ( @entity3 ) both degraded more rapidly in pure biochar than in soil. The biochar used in the present study had a maximum adsorption capacity for @entity0 of less than 5 mg g-1. There were no negative effects on pathogen and @entity1 control when the biochar used in this study was less than 1% (on a weight basis) in soil. Biochar amendment to soil reduced the emissions of @entity0 . @entity0 concentrations in the top 5 cm of soil gas-phase were reduced. @entity0 degradation was accelerated with the addition of biochar. The biochar used in the present study had a low adsorption capacity for @entity0 . There were no negative effects on pathogen and @entity1 control when the biochar amendment rate was less than 1% (by weight). The findings would be useful for establishing guidelines for biochar use in soil fumigation.

title: XXXX Emission Reduction by Soil Amendment with Biochar.

answer: @entity2


abstract: @entity1 ( @entity1 ) is a disability caused by an impairment, which can lead to a handicap of importance for nursing care. This means that @entity1 is not only a practical-medical concern but also a socio-economic problem. The purpose of the study was to determine the prevalence of @entity1 among 65 year-olds in a Swedish Health Care District and to compare gender differences concerning medical history and psychosocial consequences. In a Primary Health Care District, a questionnaire pertaining to @entity1 was mailed to all @entity0 and @entity0 65 years of age (N = 458). A total of 91% (n = 419) was sufficient for data analysis, which was performed by descriptive and inferential statistics. It was found that 28% (n = 61) of the @entity0 and 9% (n = 21) of the @entity0 were afflicted with @entity1 . @entity0 reported significantly more urge incontinence (p < .05) as well as @entity2 (p < .05). Information from the health service about @entity1 had been given to 46% (n = 28) of the @entity0 and 33% (n = 7) of the @entity0 . The strongest reason reported, both in @entity0 (42%, n = 26) and @entity0 (40%, n = 8), for not seeking help from the health service was that @entity1 was a normal condition for @entity0 of their age. Most of the @entity0 had to urinate at least twice per night (42%) compared to once per night (44%) for the @entity0 . It is important to establish a @entity1 clinic at every main Primary Health Care Centre which builds on nursing care and whose aim is to inform the general public that @entity1 is a common problem, that it leads to psychosocial consequences, and that the health service can offer active rehabilitation interventions.

title: XXXX among a 65-year old Swedish population: medical history and psychosocial consequences.

answer: @entity1