abstract: The complex implantation process is initiated by the recognition and adhesion between the embryo and uterine endometrial epithelium. The expression and interactions between the adhesive molecules from both fetal and maternal sides are crucial for the successful implantation. In this study, we aimed to investigate the expression and adhesive function of sLeX on the trophoblasts and @entity1 on uterine epithelial cells mediated the adhesion at the fetal-maternal interface, and to further explore whether this adhesion system could induce endometrial apoptosis, using in vitro implantation model consisting of the @entity0 trophoblast cell line (JAR) and @entity0 uterine epithelial cell line (RL95-2). The results showed that sLeX was expressed on JAR cells by indirect immunofluorescence staining. After transfection of JAR cells with @entity3 ( @entity3 ) which is the key enzyme for sLeX synthesis, the expression of @entity3 and sLeX synthesis were increased, and the percent adhesion of trophoblast cells to @entity0 cell monolayer was significantly increased (P  <  0.01). @entity1 was strongly expressed but not E- and @entity2 on epithelial @entity0 cells by RT-PCR, Western blot. Blocking @entity1 with specific antibody or heparin pretreatment in @entity0 cells inhibited the adhesion of JAR cells to @entity0 cell monolayer. Furthermore, regulating the expression of sLeX on JAR cells or blocking @entity1 on @entity0 cells could activate the apoptosis of uterine epithelial cells. These results suggest the sLeX/ @entity1 adhesion system at fetal-maternal interface not only mediates the adhesion of embryo to uterine epithelium, but also effectively induces the apoptosis in uterine epithelium. The study supplies a molecular basis for the elucidation of the initial recognition and adhesion during embryo implantation.

title: sLeX/ XXXX mediates adhesion in vitro implantation model.

answer: @entity1


abstract: Immunosenescence involves age-associated restructuring changes of innate and adaptative immune functions. We have suggested that these changes of the immune system participate in the rate of ageing through modulating oxi-inflamm-ageing. Thus, age-related changes in the immune system can be biological age markers and predictors of longevity. Gender differences in oxidation status and immune functions have been observed in @entity3 , with males showing higher oxidation and immunosenescence than females of the same age. Oestrogens are sex hormones that actively participate in modulating the @entity0 immune function and, therefore, the age-related impairment of the immune response is drastically accelerated in females during the menopausal transition. Ovariectomy in rodents constitutes a good model for mimicking @entity0 oestrogen loss and thus the menopausal situation. Recently, we have shown the deleterious effects of @entity4 loss on several functions of leukocytes from immune organs in @entity3 and @entity1 . In addition, ovariectomised @entity3 show similar levels in these immune functions to those in males. The present work studied several functions as well as inflammatory and oxidative stress parameters in @entity1 peritoneal macrophages and lymphocytes from old sham and ovariectomised females, as well as in males of the same age. In general, the results show that females, which have a higher immune response and a lower oxidation and @entity2 than males, appear similar to males in the parameters studied when they have lost oestrogens by ovariectomy. Thus, these data support the positive role of @entity4 in the immune function through the ageing process.

title: Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female XXXX similar to that in aged males.

answer: @entity1


abstract: BACKGROUND: Bevacizumab is a humanized monoclonal antibody that blocks vascular endothelial factor. It demonstrated an efficacy in many @entity1 types. The standard recommendation of administration is the 90-, 60-, and 30-min infusion sequence for all doses. We evaluated in this study the possibility of reducing infusion time to 10 min for bevacizumab given at 5 or 7.5 mg/kg in metastatic @entity2 (MCRC). @entity0 AND METHODS: All @entity0 who received bevacizumab for MCRC were analyzed. @entity0 were divided into two groups: Group A (bevacizumab was given in the 90-, 60-, and 30-min infusion sequence) and group B (bevacizumab was given over 10 min). @entity0 ' medical records were used to identify any @entity3 ( @entity3 ) possibly related to bevacizumab. RESULTS: There were 38 @entity0 in group A and 43 in group B. In group A, 459 doses of bevacizumab were given (286 doses at 5 mg/kg and 173 doses at 7.5 mg/kg). No @entity3 occurred in this group. In group B, 527 doses of bevacizumab were given (335 doses at 5 mg/kg and 192 doses at 7.5 mg/kg). Only two events of @entity3 grade 2 were reported in the 7.5 mg/kg infusions. Both of them were easily resolved with symptomatic treatment. CONCLUSIONS: Bevacizumab 5 or 7.5 mg/kg in MCRC can be infused safely over 10 min.

title: Bevacizumab 5 or 7.5 mg/kg in metastatic XXXX can be infused safely over 10 minutes.

answer: @entity2


abstract: CPFE-combined @entity9 and @entity8 is a new term for a syndrome whose main characteristic is @entity2 in @entity5 with simultaneous @entity8 in @entity5 . CPFE @entity0 have well preserved pulmonary test values for unexpectedly long period, but extremely lowered @entity7 diffusion capacity and significant arterial @entity3 . All CPFE studies indicate that CPFE occurs predominately in older male population. Smoking is considered main cause in developing CPFE. Reduced survival rate is linked with arterial @entity3 extent, and mortality rate is greater than that for @entity0 with isolated @entity9 or @entity8 . This study is focused on characteristics of twelve CPFE @entity0 . This paper describes cases of 12 @entity0 with the syndrome of @entity9 associated with @entity8 . All @entity0 were male, mean age of 68 years. At the certain period of life they all were smokers, but most of them were also exposed to air pollution due to their profession. Shortness of breath on exertion was present in all @entity0 . All @entity0 had neat pulmonary function tests with significantly reduced diffusing capacity for @entity6 mon- @entity10 (average 39%). @entity4 ( @entity4 ) averaged 56 mmHg (range 25-75 mmHg) was present in 75% of @entity0 . Four @entity0 died during the period of four months, of which three @entity0 had @entity4 greater than 70 mmHg. The fourth @entity0 died of @entity1 .

title: [Combined XXXX and @entity8 ].

answer: @entity9


abstract: CPFE-combined @entity9 and @entity8 is a new term for a syndrome whose main characteristic is @entity2 in @entity5 with simultaneous @entity8 in @entity5 . CPFE @entity0 have well preserved pulmonary test values for unexpectedly long period, but extremely lowered @entity7 diffusion capacity and significant arterial @entity3 . All CPFE studies indicate that CPFE occurs predominately in older male population. Smoking is considered main cause in developing CPFE. Reduced survival rate is linked with arterial @entity3 extent, and mortality rate is greater than that for @entity0 with isolated @entity9 or @entity8 . This study is focused on characteristics of twelve CPFE @entity0 . This paper describes cases of 12 @entity0 with the syndrome of @entity9 associated with @entity8 . All @entity0 were male, mean age of 68 years. At the certain period of life they all were smokers, but most of them were also exposed to air pollution due to their profession. Shortness of breath on exertion was present in all @entity0 . All @entity0 had neat pulmonary function tests with significantly reduced diffusing capacity for @entity6 mon- @entity10 (average 39%). @entity4 ( @entity4 ) averaged 56 mmHg (range 25-75 mmHg) was present in 75% of @entity0 . Four @entity0 died during the period of four months, of which three @entity0 had @entity4 greater than 70 mmHg. The fourth @entity0 died of @entity1 .

title: [Combined @entity9 and XXXX ].

answer: @entity8


abstract: AIM: The aim of the study was to identify the presence of @entity2 ( @entity2 ) in @entity0 who had sustained @entity3 , additionally, we aimed to identify other variables that may modify the psychological response to @entity1 that include gender, age and presence of disfigurement post-treatment and visible scars/orthopedic injuries. MATERIALS AND METHODS: @entity0 comprised of 460 @entity0 from several multinodal @entity1 centers in Bengaluru City, Karnataka, who had sustained @entity3 that had healed either with or without significant disfigurement or scarring and with visible/orthopedic injuries. One hundred and eleven @entity0 of the chosen 460 had sustained nondisfiguring @entity3 while 153 @entity0 sustained disfiguring @entity3 , 64 @entity0 who sustained @entity3 (i.e. 19.5%) were lost to follow-up and were not included in the study. One hundred and thirty-two had sustained orthopedic/visible injuries; however, in this group, 18 (i.e. 13.6%) @entity0 were lost to follow-up and were excluded from the study. The impact of events scale (IES) was used to check the presence of @entity2 . RESULTS: Statistically significant higher means of IES were present in @entity0 with disfiguring @entity3 compared to nondisfiguring @entity3 , female @entity0 compared to male @entity0 , @entity0 with disfiguring @entity3 compared to orthopedic/visible injuries and @entity0 who were younger than 50 years of age compared to @entity0 who were older than 50 years of age and the results observed were similar at all three study intervals (date of discharge (DOD), 1 month and 6 months postoperatively). CONCLUSION: @entity0 with disfiguring @entity3 had significantly higher @entity2 levels compared to @entity0 with nondisfiguring @entity3 , @entity0 with orthopedic/visible injuries had statistically significant lower IES scores which could not be strictly termed @entity2 when compared to @entity0 with disfiguring @entity3 who had high scores of IES corresponding to high levels of @entity2 and these results were observed at all three study intervals (DOD, 1 and 6 months postoperatively). Female @entity0 with disfiguring @entity3 had significantly higher @entity2 levels compared to male @entity0 (at all the study intervals) and @entity0 younger than 50 years of age had significantly higher @entity2 levels compared to older @entity0 .

title: @entity2 in XXXX : A Comparative Study.

answer: @entity3


abstract: AIM: The aim of the study was to identify the presence of @entity2 ( @entity2 ) in @entity0 who had sustained @entity3 , additionally, we aimed to identify other variables that may modify the psychological response to @entity1 that include gender, age and presence of disfigurement post-treatment and visible scars/orthopedic injuries. MATERIALS AND METHODS: @entity0 comprised of 460 @entity0 from several multinodal @entity1 centers in Bengaluru City, Karnataka, who had sustained @entity3 that had healed either with or without significant disfigurement or scarring and with visible/orthopedic injuries. One hundred and eleven @entity0 of the chosen 460 had sustained nondisfiguring @entity3 while 153 @entity0 sustained disfiguring @entity3 , 64 @entity0 who sustained @entity3 (i.e. 19.5%) were lost to follow-up and were not included in the study. One hundred and thirty-two had sustained orthopedic/visible injuries; however, in this group, 18 (i.e. 13.6%) @entity0 were lost to follow-up and were excluded from the study. The impact of events scale (IES) was used to check the presence of @entity2 . RESULTS: Statistically significant higher means of IES were present in @entity0 with disfiguring @entity3 compared to nondisfiguring @entity3 , female @entity0 compared to male @entity0 , @entity0 with disfiguring @entity3 compared to orthopedic/visible injuries and @entity0 who were younger than 50 years of age compared to @entity0 who were older than 50 years of age and the results observed were similar at all three study intervals (date of discharge (DOD), 1 month and 6 months postoperatively). CONCLUSION: @entity0 with disfiguring @entity3 had significantly higher @entity2 levels compared to @entity0 with nondisfiguring @entity3 , @entity0 with orthopedic/visible injuries had statistically significant lower IES scores which could not be strictly termed @entity2 when compared to @entity0 with disfiguring @entity3 who had high scores of IES corresponding to high levels of @entity2 and these results were observed at all three study intervals (DOD, 1 and 6 months postoperatively). Female @entity0 with disfiguring @entity3 had significantly higher @entity2 levels compared to male @entity0 (at all the study intervals) and @entity0 younger than 50 years of age had significantly higher @entity2 levels compared to older @entity0 .

title: XXXX in @entity3 : A Comparative Study.

answer: @entity2


abstract: BACKGROUND: @entity3 ( @entity6 ) is an important risk factor for @entity1 ( @entity1 ). However, little is known about the characteristics of @entity1 @entity0 with @entity6 . This study investigated the characteristics of such @entity0 , using data from a retrospective, observational, multicenter study. METHODS: @entity1 @entity0 admitted to 13 @entity2 centers in Japan within 7 days of onset between January 2008 and December 2009 were included. The present analyses compared baseline characteristics, clinical symptoms, findings from diffusion-weighted imaging (DWI), and clinical outcomes between @entity0 with and without @entity6 ( @entity6 and @entity6 ). RESULTS: A total of 464 @entity0 (292 @entity0 ; mean age 68.5    13.2 years) were registered. Of these, 79 @entity0 (17%) had @entity6 . @entity0 in the @entity6 group were older (73.9    9.1 vs. 67.4    13.6 years, p < 0.001) and more likely to show disturbance of consciousness (13 vs. 6%, p = 0.046) and @entity4 (9 vs. 3%, p = 0.007) than @entity0 in the non- @entity6 group. Although no difference in the overall DWI-positive rate was seen between the groups (28 vs. 20%, p = 0.102), a single lesion (23 vs. 10%, p < 0.001), a lesion >= 15 mm (11 vs. 4%, p = 0.006), and a single lesion >= 15 mm (11 vs. 2%, p < 0.001) on DWI were more frequent in the @entity6 group. Multivariate logistic regression analysis identified increased age [odds ratio (OR) 1.04; 95% confidence interval (CI) 1.02-1.07] and DWI single lesion >= 15 mm (OR 5.67; 95% CI 1.92-16.7) as independently associated with the presence of @entity6 . CONCLUSIONS: In this study, 17% of our @entity1 @entity0 had @entity6 . We found an association between the @entity5 pattern on DWI of a single lesion >= 15 mm and @entity6 in @entity1 @entity0 . These results might lead to a better diagnosis of @entity1 @entity0 with @entity6 .

title: Clinical Characteristics of @entity1 @entity0 with XXXX : Analyses of a Multicenter Retrospective Study.

answer: @entity3


abstract: BACKGROUND: @entity3 ( @entity6 ) is an important risk factor for @entity1 ( @entity1 ). However, little is known about the characteristics of @entity1 @entity0 with @entity6 . This study investigated the characteristics of such @entity0 , using data from a retrospective, observational, multicenter study. METHODS: @entity1 @entity0 admitted to 13 @entity2 centers in Japan within 7 days of onset between January 2008 and December 2009 were included. The present analyses compared baseline characteristics, clinical symptoms, findings from diffusion-weighted imaging (DWI), and clinical outcomes between @entity0 with and without @entity6 ( @entity6 and @entity6 ). RESULTS: A total of 464 @entity0 (292 @entity0 ; mean age 68.5    13.2 years) were registered. Of these, 79 @entity0 (17%) had @entity6 . @entity0 in the @entity6 group were older (73.9    9.1 vs. 67.4    13.6 years, p < 0.001) and more likely to show disturbance of consciousness (13 vs. 6%, p = 0.046) and @entity4 (9 vs. 3%, p = 0.007) than @entity0 in the non- @entity6 group. Although no difference in the overall DWI-positive rate was seen between the groups (28 vs. 20%, p = 0.102), a single lesion (23 vs. 10%, p < 0.001), a lesion >= 15 mm (11 vs. 4%, p = 0.006), and a single lesion >= 15 mm (11 vs. 2%, p < 0.001) on DWI were more frequent in the @entity6 group. Multivariate logistic regression analysis identified increased age [odds ratio (OR) 1.04; 95% confidence interval (CI) 1.02-1.07] and DWI single lesion >= 15 mm (OR 5.67; 95% CI 1.92-16.7) as independently associated with the presence of @entity6 . CONCLUSIONS: In this study, 17% of our @entity1 @entity0 had @entity6 . We found an association between the @entity5 pattern on DWI of a single lesion >= 15 mm and @entity6 in @entity1 @entity0 . These results might lead to a better diagnosis of @entity1 @entity0 with @entity6 .

title: Clinical Characteristics of XXXX @entity0 with @entity3 : Analyses of a Multicenter Retrospective Study.

answer: @entity1


abstract: BACKGROUND: @entity3 ( @entity6 ) is an important risk factor for @entity1 ( @entity1 ). However, little is known about the characteristics of @entity1 @entity0 with @entity6 . This study investigated the characteristics of such @entity0 , using data from a retrospective, observational, multicenter study. METHODS: @entity1 @entity0 admitted to 13 @entity2 centers in Japan within 7 days of onset between January 2008 and December 2009 were included. The present analyses compared baseline characteristics, clinical symptoms, findings from diffusion-weighted imaging (DWI), and clinical outcomes between @entity0 with and without @entity6 ( @entity6 and @entity6 ). RESULTS: A total of 464 @entity0 (292 @entity0 ; mean age 68.5    13.2 years) were registered. Of these, 79 @entity0 (17%) had @entity6 . @entity0 in the @entity6 group were older (73.9    9.1 vs. 67.4    13.6 years, p < 0.001) and more likely to show disturbance of consciousness (13 vs. 6%, p = 0.046) and @entity4 (9 vs. 3%, p = 0.007) than @entity0 in the non- @entity6 group. Although no difference in the overall DWI-positive rate was seen between the groups (28 vs. 20%, p = 0.102), a single lesion (23 vs. 10%, p < 0.001), a lesion >= 15 mm (11 vs. 4%, p = 0.006), and a single lesion >= 15 mm (11 vs. 2%, p < 0.001) on DWI were more frequent in the @entity6 group. Multivariate logistic regression analysis identified increased age [odds ratio (OR) 1.04; 95% confidence interval (CI) 1.02-1.07] and DWI single lesion >= 15 mm (OR 5.67; 95% CI 1.92-16.7) as independently associated with the presence of @entity6 . CONCLUSIONS: In this study, 17% of our @entity1 @entity0 had @entity6 . We found an association between the @entity5 pattern on DWI of a single lesion >= 15 mm and @entity6 in @entity1 @entity0 . These results might lead to a better diagnosis of @entity1 @entity0 with @entity6 .

title: Clinical Characteristics of @entity1 XXXX with @entity3 : Analyses of a Multicenter Retrospective Study.

answer: @entity0


abstract: BACKGROUND: Thyroid @entity3 (TM) are uncommon. Dependent on study design, the reported frequency of TM is in the range of 0.1-6% in different analyses. While clinical and histopathological features of TM were well described in the literature, radiological publications consist predominantly of isolated case reports or small series. PURPOSE: To estimate the prevalence, clinical signs, and radiological appearances of TM. MATERIAL AND METHODS: From 1997 to 2013, a total of 8849 @entity1 with various disorders of the thyroid gland were treated in our institution. In 33 @entity1 TM were diagnosed. Ultrasound (US) images were available in all @entity1 , computed tomography (CT) of the neck in 16 @entity1 , and magnetic resonance imaging (MRI) in nine @entity1 . RESULTS: Clinically, most @entity1 (85%) presented with a painless neck mass. @entity4 were @entity7 (79%), @entity5 (12%), @entity2 (3%), @entity6 (3%), and @entity0 (3%). On US, most lesions were irregular in shape with inhomogenous texture. On CT, all TM were hypodense. On T1-weighted images, most TM were inhomogenously iso-to-hyperintense in comparison to the normal thyroid tissue, and slightly hyperintense on T2-weighted images with an inhomogenous contrast enhancement. CONCLUSION: The prevalence of TM was 0.4%. Most of the TM originated from @entity7 . The identified radiological features of TM should be taken into consideration in the differential diagnosis of @entity8 .

title: Radiological features of XXXX to the thyroid.

answer: @entity3


abstract: INTRODUCTION: The QTc interval depends largely on cardiac repolarization since the duration of @entity2 is fairly constant in the normal heart. QTc at rest as well as during exercise has many clinical implications. In this study, we have compared the relative effects of dynamic and static exercise on QTc. AIM: To measure QTc interval in young @entity0 at rest and also assess how it is further modulated by submaximal dynamic and static exercises. MATERIALS AND METHODS: This observational study was conducted in the Department of Physiology on 30 non-obese young @entity0 randomly selected from the students of our institute after obtaining the consent and institutional ethical clearance. Continuous blood pressure monitoring and ECG recording was done in the subjects. Baseline (pre-exercise), post submaximal dynamic (Harvard's step test) and post submaximal static exercise (hand-grip exercise) recordings of @entity5 and ECG were taken for analysis. The measured QT interval was corrected for heart rate using the formula of Bazett et al., {QTc=QT/RR(1/2)}.Statistical analysis was done using Graph pad Prism 5 software (California, USA). The baseline and post-exercise data were compared using paired t-test. A p<0.05 was taken to be statistical significant. RESULTS: There were statistically significant increases in HR, @entity3 , @entity4 and QTc interval after dynamic exercise in comparison to the baseline values (p<0.05). Significant increase in HR (p<0.05) with no significant change in QTc and other @entity1 were recorded following static exercise (p>0.05). CONCLUSION: Significant increase in QTc interval was observed after dynamic exercise, however, no change in QTc was observed following static exercise, and hence we conclude that static exercises may not be useful in assessing the cardiovascular status of an individual or in predicting @entity1 .

title: Effect of Sub Maximal Dynamic and Static Exercises on QTc interval in Healthy Young XXXX .

answer: @entity0


abstract: BACKGROUND: @entity3 are a known complication late after Fontan operation. Limited information is available on their prognostic value. METHODS: All @entity0 with previous Fontan operation followed at our institution since 1999 were identified from the electronic database and included in this study. Demographic and clinical characteristics including history of @entity3 were recorded at the earliest full clinical assessment and @entity0 were followed thereafter for all-cause mortality and hospitalization. RESULTS: A total of 98 @entity0 , mean age 31.5    8.9 years, 43.8% male, 31.6% with a total cavopulmonary connection (TCPC) were identified. A history of @entity3 was present at baseline in 60.2% of @entity0 who were older (33.0    8.3 vs 29.1    9.4 years, p=0.002), less likely to have a TCPC (13.5% vs 58.9%, p<0.001), and more symptomatic in terms of NYHA class (51.9% vs 26.7%, p=0.007) compared to @entity2 -free @entity0 . During a median follow-up of 6.7 years 18 @entity0 died and 64 @entity0 were hospitalized. Even after adjustment for baseline clinical characteristics, @entity3 was an independent predictor of @entity1 (propensity score adjusted HR 9.35, 95% CI: 1.10-79.18, p=0.04, c-statistic 0.88) and composite of @entity1 or hospitalization (propensity score adjusted HR 5.00, 95% CI: 2.47-10.09, p<0.0001). CONCLUSIONS: In adult @entity0 with a Fontan-type operation, the presence of @entity3 is associated with higher morbidity and mortality at mid-term follow-up. Whether early @entity2 targeting intervention may improve clinical outcome needs to be studied in a prospective manner.

title: XXXX late after Fontan operation are related to increase in mortality and hospitalization.

answer: @entity3


abstract: UNASSIGNED: Background: Dermoid cysts are frequent unilateral @entity1 that can be found at different locations throughout the body. In the orbital region, @entity2 occur predominantly in the supero-temporal quadrant. However, different orbital locations are possible, making this entity an important differential diagnosis for @entity1 . @entity0 and Methods: We retrospectively reviewed the charts of 23 consecutive @entity0 operated in our institution between 2005 and 2014 for @entity1 that were diagnosed as congenital dermoid or @entity3 . Results: There were 21 dermoid and 2 @entity3 . The median age at surgery time was 7 years (range 1-41). There were 15 females and 8 males. Eleven cysts were located supero-temporally (47.8%), seven supero-medially (30.4%), two temporally (8.7%), one at the frontal bone (4.4%) and two in the fossa of the lacrimal gland (8.7%). The mean cyst diameter was 13.1   mm      5.0 (SD). None had signs of @entity1 . No recurrence was observed after complete excision. Conclusion: Dermoid cysts of orbital region are mostly located in the supero-temporal quadrant. However, other orbital locations are possible and @entity2 must thus be considered in the differential diagnosis of any mass in the orbital region.

title: Different Locations of XXXX in the Orbital Region.

answer: @entity2


abstract: OBJECTIVE: To evaluate treatment effectiveness (diet alone, insulin or @entity4 ) on maternal weight @entity5 (GDM). METHODS: GDM @entity0 were treated with diet alone, insulin or @entity4 . @entity3 was stratified into: prior to GDM diagnosis, from diagnosis to @entity3 . Good glycemic control was defined as mean blood @entity2  <=105   mg/dl and @entity1 as Body Mass Index (BMI)   >=    30   kg/m(2), overweight BMI 25-29   kg/m(2) and normal <   25   kg/m(2). RESULTS: Total @entity3 was similar in all the treatment groups. Two-thirds of @entity3 occurred prior to diagnosis (diet 85%, insulin 67% and @entity4 78%). Post-diagnosis, @entity0 on diet alone gained less weight than those on insulin or @entity4 (p   <   0.001); insulin-treated @entity0 showed greater @entity3 than @entity4 -treated @entity0 (p   <   0.001). @entity0 on diet with good glycemic control showed less @entity3 after diagnosis than @entity0 on insulin or @entity4 (2.8        13, 6.6        10, 5.2        7.9 lbs, respectively, p   <   0.02). Poorly-controlled @entity0 , regardless of treatment, had similar patterns of @entity3 throughout pregnancy. CONCLUSION: Patterns of maternal @entity3 in GDM pregnancies are associated with treatment modality and level of glycemic control.

title: Weight XXXX : the effect of treatment modality.

answer: @entity5


abstract: Background. Vacuum-assisted closure (V.A.C.   Therapy, KCI, San Antonio, TX) has been widely used to increase the healing rate of a variety of wounds. It has been hypothesized that one of the actions of VAC is to increase perfusion and subsequent oxygenation of tissue. The aim of the present study was to investigate the effect of VAC therapy on transcutaneous oximetry measurements (TCOM) of skin surrounding chronic ven @entity3 ETHODS: This was a prospective, experimental pilot study. Pat @entity0 dergoing compression therapy were recruited from a community wound clinic. All pat @entity0 d ankle-brachial pressure indices (ABPI) > 0.8. Three TCOM values were taken from around the ulc @entity2 d a reference TCOM was taken from the chest. Negative pressure was applied on the ulc @entity2 125-mmHg continuous subatmospheric pressure and four-layer compression bandaging over the VAC drapes. The duration of the study was 6 days. On day 6, dressings were removed and TCOM was repeated at the same skin sites. RESULTS: Fourteen of the 17 pat @entity0 mpleted the trial. The median age was 73 years (range 49-85). No significant difference was found in oxy @entity1 rtial pressure pre-and post-VAC therapy around the ulc @entity2 te (mean 41.5 mmHg versus 40 mmHg [P = 0.67]). There was a significant difference in TCOM between the reference point and the periwound area (mean 60.5 versus 40 [P < 0.0005]). CONCLUSION: This pilot study suggests that VAC therapy does not change oxy @entity1 rtial pressure around ven @entity3 COM of the skin around ulcers were low despite normal ABPIs.

title: The Effect of Vacuum-assisted Closure on the Tissue Oxygenation of Venous Ulcers: A P XXXX .

answer: @entity3


abstract: AIMS: Ultrasound-targeted microbubble destruction (UTMD) uses ultrasound energy to selectively deliver genes into the myocardium using plasmids conjugated to microbubbles. We hypothesized that repeated delivery of stem cell-mobilizing genes could boost the ability of this therapy to enhance cardiac repair and ventricular function after a @entity1 . METHODS AND RESULTS: Beginning 7 days after coronary artery ligation, @entity3 ( @entity3 ) and stromal cell-derived factor (SDF)-1a genes were administered to adult @entity0 using 1, 3, or 6 UTMD treatments (repeat 1, 3, and 6 groups) at 2-day intervals (control=6 treatments with empty plasmid). Cardiac function (echocardiography) and myocardial perfusion (myocardial contrast echocardiography) were assessed on Days -7, 0, and 24 relative to the first treatment. Histological and biochemical assessments were performed on Day 24. Multiple UTMD treatments were associated with an increased presence of myocardial @entity3 and SDF-1a proteins and their receptors (vs. control and Repeat 1). All UTMD recipients exhibited increased vascular densities and smaller @entity2 regions (vs. control), with the highest ventricular densities in response to multiple treatments. Myocardial perfusion and ventricular function at Day 24 also improved progressively (vs. control) with the number of UTMD treatments. CONCLUSIONS: Targeted ultrasound delivery of @entity3 and SDF-1a genes to the infarcted myocardium recruited progenitor cells and increased vascular density. Multiple UTMD treatments enhanced tissue repair, perfusion, and cardiac function. Repeated UTMD therapy may be applied to tailor the number of interventions required to optimize cardiac regeneration after an @entity2 .

title: Repeated and targeted transfer of angiogenic plasmids into the infarcted XXXX heart via ultrasound targeted microbubble destruction enhances cardiac repair.

answer: @entity0


abstract: BACKGROUND: It is estimated that disease burden due to low fruit and vegetable consumption is higher in Central and Eastern Europe (CEE) and the former Soviet Union (FSU) than any other parts of the world. However, no large scale studies have investigated the association between fruit and vegetable (F_V) intake and mortality in these regions yet. DESIGN: The Health, @entity5 and Psychosocial Factors in Eastern Europe (HAPIEE) study is a prospective cohort study with @entity0 recruited from the Czech Republic, Poland and Russia. METHODS: Dietary data was collected using food frequency questionnaire. Mortality data was ascertained through linkage with @entity4 registers. Multivariable adjusted hazard ratios were calculated by Cox regression models. RESULTS: Among 19,333 disease-free @entity0 at baseline, 1314 died over the mean follow-up of 7.1 years. After multivariable adjustment, we found statistically significant inverse association between cohort-specific quartiles of F_V intake and @entity1 mortality: the highest vs lowest quartile hazard ratio (HR) was 0.52 (95% confidence interval (CI): 0.28-0.98). For total mortality, significant interaction (p   =   0.008) between F_V intake and smoking was found. The associations were statistically significant in smokers, with HR 0.70 (0.53-0.91, p for trend: 0.011) for total mortality, and 0.62 (0.40-0.97, p for trend: 0.037) for @entity2 ( @entity2 ) mortality. The association was appeared to be mediated by blood pressure, and F_V intake explained a considerable proportion of the mortality differences between the Czech and Russian cohorts. CONCLUSIONS: Our results suggest that increasing F_V intake may reduce @entity2 mortality in CEE and FSU, particularly among smokers and @entity3 individuals.

title: Fruit and vegetable consumption and mortality in Eastern Europe: Longitudinal results from the Health, XXXX and Psychosocial Factors in Eastern Europe study.

answer: @entity5


abstract: OBJECTIVES: It was recently demonstrated that adverse cardiovascular events (ACVE) complicate a high proportion of hospitalizations for @entity0 with acute drug @entity7 . The aim of this study was to derive independent clinical risk factors for ACVE in @entity0 with acute drug @entity7 . METHODS: This prospective cohort study was conducted over 3 years at two urban university hospitals. @entity0 were adults with acute drug @entity7 enrolled from the ED. In-hospital ACVE was defined as any of @entity1 , shock, @entity3 , or @entity6 . RESULTS: There were 1,562 @entity0 meeting inclusion/exclusion criteria (mean age, 41.8 years; female, 46%; suicidal, 38%). ACVE occurred in 82 (5.7%) @entity0 ( @entity1 , 61; shock, 37; @entity3 , 23; cardiac arrests, 22) and there were 18 (1.2%) deaths. On univariate analysis, ACVE risk increased with age, lower serum @entity8 , @entity5 , prior @entity2 , and @entity4 . In a multivariable model adjusting for these factors as well as @entity0 sex and hospital site, independent predictors were: QTc > 500 msec (3.8% prevalence, odds ratio [OR]  = 27.6), @entity8 < 20 mEq/L (5.4% prevalence, OR  = 4.4), and prior @entity2 (7.1% prevalence, OR  = 9.5). The derived prediction rule had 51.6% sensitivity, 93.7% specificity, and 97.1% negative predictive value, while presence of two or more risk factors had 90.9% positive predictive value. CONCLUSIONS: The authors derived independent clinical risk factors for ACVE in @entity0 with @entity7 , which should be validated in future studies as a prediction rule in distinct @entity0 populations and clinical settings.

title: Clinical Risk Factors for In-hospital Adverse Cardiovascular Events After Acute Drug XXXX .

answer: @entity7


abstract: OBJECTIVE: To estimate the prevalence of @entity7 in rural and urban populations using the WHO-ILAR COPCORD questionnaire. METHODS: We conducted a cross-sectional home survey in subjects > 18 years of age in the Mexican state of Nuevo Leon. Results were validated locally against physical examination in positive cases according to an operational definition by 2 rheumatologists. We used a random, balanced, and stratified sample by region of representative subjects. RESULTS: We surveyed 4713 individuals with a mean age of 43.6 years (SD 17.3); 55.9% were @entity0 and 87.1% were from urban areas. Excluding @entity1 , 1278 individuals (27.1%, 95% CI 25.8%-28.4%) reported @entity8 in the last 7 days; the prevalence of this variable was almost twice as frequent in @entity0 (33% vs 17% in @entity0 ); 529 (11.2%) had @entity2 associated with @entity1 . The global prevalence of @entity2 was 38.3%. Mean @entity2 score was 2.4 (SD 3.4) on a @entity2 scale of 0-10. Most subjects classified as positive according to case definition (99%) were evaluated by a rheumatologist. Main diagnoses were @entity5 in 17.3% (95% CI 16.2-18.4), back @entity2 in 9.8% (95% CI 9.0-10.7), undifferentiated @entity6 in 2.4% (95% CI 2.0-2.9), @entity4 in 0.4% (95% CI 0.2-0.6), @entity3 in 0.8% (95% CI 0.6-1.1), and gout in 0.3% (95% CI 0.1-0.5). CONCLUSION: This is the first regional COPCORD study in Mexico performed with a systematic sampling, showing a high prevalence of @entity2 . COPCORD is a useful tool for the early detection of @entity7 as well as for accurately referring @entity0 to different medical care centers and to reduce underreporting of @entity7 .

title: Epidemiology of XXXX . A community-based study in urban and rural populations in the state of Nuevo Leon, Mexico.

answer: @entity7


abstract: BACKGROUND/AIM: Malnutrition in elderly @entity0 is common in hospitals, and many of the age associated @entity1 have a common factor, which is oxidative stress. The aim of the study was to evaluate the nutritional status, @entity2 , and oxidant status of elderly @entity0 . @entity0 AND METHODS: The mini-nutritional assessment (MNA) was used to determine the nutritional status of elderly @entity0 . @entity2 concentration in the whole blood, plasma albumin, and @entity4 -reactive substances (TBARS) levels was measured spectrophotometrically by the enzymatic recycling method. In addition, length of hospital stay was estimated. All measurements were taken within 48 h after admission. RESULTS: The results showed that more than two-thirds of the elderly were classified as at risk of @entity3 and malnourished. About 45% and 53% elevation in the TBARS was found in at risk of being malnourished and in the malnourished groups, respectively, compared to the well-nourished group, but the elevation did not reach the significant level. No significant differences in the @entity2 concentration and in the length of hospital stay were found among the three mini-nutritional assessment categories. CONCLUSIONS: The study indicated the necessity of performing the MNA test for elderly upon admission to hospitals, and more attention needs to be paid to this vulnerable group of @entity0 .

title: The nutritional, XXXX and oxidant status of elderly subjects admitted to a university hospital.

answer: @entity2


abstract: BACKGROUND: The aim was to investigate whether the effects of major risk factors for @entity4 were modified by long-term exposure to air pollution in Scania, southern Sweden. METHODS: Cases were defined as first-ever @entity4 in @entity0 born between 1923 and 1965 during 2001-2006 (n = 7,244). Data were collected from The Swedish National @entity2 Register (Riks- @entity2 ) and the Malm   and Lund @entity2 Registers. Population controls were matched on age and sex. Modeled outdoor annual mean NO(x) concentrations were used as proxy for long-term exposure to air pollution. Heterogeneity across NO(x) categories was tested for smoking, @entity3 , @entity1 , @entity5 and physical inactivity. Data were analyzed as case-control data and to some extent as case-only data, with logistic regression analysis. RESULTS: The case-control odds ratios for @entity4 in association with @entity1 were 1.3 [95% confidence interval (CI): 1.1-1.6] and 2.0 (95% CI: 1.2-3.4) in the lowest and highest NO(x) category, respectively (p value for testing heterogeneity across the categories = 0.056). The case-only approach gave further support for the risk associated with @entity1 to increase with NO(x) (p for trend = 0.033). We observed no main effect of mean NO(x) or any conclusive effect modifications between NO(x) and smoking, @entity3 , @entity5 or physical inactivity. CONCLUSIONS: In a low-level air pollution area, the risk for @entity4 associated with @entity1 seemed to increase with long-term exposure to air pollution.

title: Hospital admissions for XXXX : does long-term exposure to air pollution interact with major risk factors?

answer: @entity4


abstract: BACKGROUND: @entity0 with @entity7 ( @entity7 ) are at increased risk of @entity2 because of associated @entity1 , @entity5 , @entity6 and @entity8 . Although suggested to be beneficial, the cardiac effects of renal artery revascularization have not been well characterized. Our aim was to analyze the effects of percutaneous dilatation of @entity9 ( @entity9 ) in @entity7 @entity0 on coronary and peripheral vascular function. METHODS: Nineteen @entity7 @entity0 [11 females and 8 males, age at study entry (mean    SD) 69    10 years] were treated by dilatation of unilateral (n = 9) or bilateral (n = 10) @entity9 , mainly because of uncontrolled or refractory @entity1 . The @entity0 were studied before and after the procedure (103    29 days). They underwent echocardiography and peripheral artery endothelial function testing using @entity3 ( @entity3 ) of brachial artery at rest and during reactive @entity4 . Myocardial blood flow was measured using quantitative PET perfusion imaging at baseline and during @entity10 -induced @entity4 . RESULTS: Peripheral endothelial function, tested by @entity3 , as well as systolic blood pressure and left ventricular mass were improved in @entity0 with bilateral @entity9 . However, myocardial perfusion and coronary flow reserve (CFR) did not change after the @entity9 dilatation. CONCLUSION: This is the first study to analyze the stage of myocardial perfusion and CFR in @entity7 @entity0 . Although peripheral endothelial function, systolic blood pressure and @entity11 were improved in @entity0 with bilateral @entity9 by revascularization of @entity9 , it did not have any effect on coronary perfusion.

title: The effect of revascularization of XXXX on coronary flow reserve and peripheral endothelial function.

answer: @entity9


abstract: An autopsy case of @entity15 preceded by urinary disturbance for over 20 years was reported. A 43-year-old @entity0 was admitted to our hospital because of urinary disturbance and @entity7 . At the age of 19 she developed urinary disturbance with @entity11 and retention. These symptoms were getting worse with years, and at the age of 33 she was diagnosed to have @entity8 of uninhibited type. During her hospital course her symptom became worse, and by the age of 42 she showed marked @entity13 , disturbance of smooth pursuit eye movement, @entity14 , marked @entity10 and @entity5 of four extremities, generalized @entity6 , marked limb and @entity12 , @entity8 and @entity7 . Serial brain CT scan revealed progressive brain stem and @entity2 with clinical course. Severe @entity1 were also documented. She died of @entity9 at the age of 43. On autopsy, brain stem and cerebellum showed marked @entity4 macroscopically. Microscopically marked depletion of neuron was seen in the substantia nigra, pontine nuclei, inferior olive, Purkinje cells, the intermediolateral column of spinal cord and Onuf's nucleus of S2. Although numerous cases of @entity15 have been reported in the past, there is no case which developed this syndrome after urinary disturbance of over 20 year's duration. We should be alert to observe the cases with longstanding urinary disturbances in order to not overlook @entity3 as exemplified in this case.

title: [An autopsy case of XXXX preceded by a urinary disturbance for over 20 years].

answer: @entity15


abstract: We reported a case of @entity1 , @entity1 , with groping in response to a visual stimulus ("visual groping"). T.S. was a right-handed @entity0 , 69 years old. In the beginning she displayed "visual groping" of the right hand, besides @entity3 , lowered registration and Casteigne's "Motor neglect" of the right upper extremity. As the disease progressed, "visual groping" of the left hand developed, followed by "forced grasping" of the left hand. When the @entity0 was 62 years old, she first showed decreased volition and lowered registration. Later poor finger movement and lessened speech were marked. At the age of 69, she was admitted to our hospital with @entity3 and reduced registration. The @entity0 showed preservation in naming and drawing tests. She also displayed a "visual groping" phenomenon of the right hand. This phenomenon was revealed when an examiner displayed something about 50 cm in front of the @entity0 , and then she extended the upper extremity gropingly. We considered this phenomenon as "groping in response to a visual stimulus" of Denny-Brown. At the same time, the motor or praxic disorder of this @entity0 consisted of paucity of movement. When she was told to imitate, her right upper extremity was hardly utilized, although later movements could be realized by her practice. When she was told to pour water from one glass into another, she used her left hand, although she used her right hand for spontaneous actions. So we considered this @entity2 as a motor neglect of Casteigne.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [The groping phenomena in a case of XXXX ].

answer: @entity1


abstract: BACKGROUND: although recent studies have suggested that @entity1 may play an important role in the process of ageing and in the development of disabilities, knowledge about the role of @entity1 in physical performance decline among middle-aged and older @entity0 in the context of developing countries is limited. OBJECTIVES: to examine the association between @entity3 ( @entity3 ) and the activities of daily living (ADL) among middle-aged (40-54 years old) and older (55-96 years old) @entity0 in Indonesia. DATA: data from a population-based sample, the Indonesia Family Life Survey (IFLS) 2007, were analysed. The data consist of 1,702 respondents of middle age (40-54 years old) and 2,017 older respondents who had completed information on ADL and @entity3 . METHODS: @entity3 concentrations in Dried Blood Spot (DBS) specimens were measured, using the validated enzyme-linked immunosorbent assay (ELISA) method. Thirteen items of ADL were used to measure physical performance. A three-level linear model was applied to take advantage of the nested structure of data at the individual level within the household and community levels. RESULTS: high levels of @entity3 were significantly associated with lower ADL for middle-aged and older @entity0 (P < 0.001). The model was adjusted for co-morbid conditions, health risk factors, medications, @entity2 and sociodemographic characteristics. CONCLUSION: the significant association between the high level of @entity3 and lower ADL among older @entity0 in Indonesia is in line with earlier studies in the context of developed countries. This study provides an extension in which the significant association was also found in middle-aged @entity0 (40-54 years old).

title: Inflammatory markers and physical performance in middle-aged and older XXXX in Indonesia.

answer: @entity0


abstract: Although some cases of spoon nails and @entity7 are manifestations of internal disease, a significant number are completely idiopathic and of no consequence to the @entity0 . Many @entity0 have been forced to pay high insurance premiums or have been denied employment because of insignificant nail changes. When a @entity0 has spoon nails or @entity7 , a thorough but reasonable search for a primary etiology should be made. It should be recalled that when the complete syndrome of @entity6 is present and joint @entity4 is prominent, the possibility of a @entity3 is great. If a cause of spooning or @entity7 is found, it should be treated. However, when the physician becomes satisfied that no associated disorder exists, he should reassure the @entity0 . In the author's experience @entity8 is most commonly due to @entity5 , fungus, or @entity2 . It is hypothesized that the curvature changes in spoon and clubbed nails are the result of angulation of the nail matrix secondary to connective tissue changes. The structural hypothesis presented here is largely based on observations of @entity1 . These cases have allowed visualization of the angle of the nail matrix. Both spoon nails and @entity7 are such definite reaction patterns that there must be some common mechanism for @entity1 . Structural rules that should apply to the nail have been used. It is easy to think of multiple internal disorders producing the same connective tissue changes that alter the angle of the nail matrix. It is difficult to think of another mechanism by which internal disease could alter the bonds in hard keratin.

title: XXXX and @entity8 .

answer: @entity7


abstract: Although some cases of spoon nails and @entity7 are manifestations of internal disease, a significant number are completely idiopathic and of no consequence to the @entity0 . Many @entity0 have been forced to pay high insurance premiums or have been denied employment because of insignificant nail changes. When a @entity0 has spoon nails or @entity7 , a thorough but reasonable search for a primary etiology should be made. It should be recalled that when the complete syndrome of @entity6 is present and joint @entity4 is prominent, the possibility of a @entity3 is great. If a cause of spooning or @entity7 is found, it should be treated. However, when the physician becomes satisfied that no associated disorder exists, he should reassure the @entity0 . In the author's experience @entity8 is most commonly due to @entity5 , fungus, or @entity2 . It is hypothesized that the curvature changes in spoon and clubbed nails are the result of angulation of the nail matrix secondary to connective tissue changes. The structural hypothesis presented here is largely based on observations of @entity1 . These cases have allowed visualization of the angle of the nail matrix. Both spoon nails and @entity7 are such definite reaction patterns that there must be some common mechanism for @entity1 . Structural rules that should apply to the nail have been used. It is easy to think of multiple internal disorders producing the same connective tissue changes that alter the angle of the nail matrix. It is difficult to think of another mechanism by which internal disease could alter the bonds in hard keratin.

title: @entity7 and XXXX .

answer: @entity8


abstract: BACKGROUND: A ready to use @entity4 valerate 0.1% ( @entity2 ) dressing was effective and well-tolerated by @entity0 receiving chronic plaque psoriasis treatment. OBJECTIVE: Collect data related to @entity2 dressing used in the context of market authorization. METHODS: An observational, prospective study, including 258 @entity0 with a maximum 4-weeks-treatment of inflammatory dermatosis with @entity2 2.25   mg plaster was performed. The prescription pattern was described and the disease severity assessed using a @entity3 ( @entity3 ). @entity0 satisfaction as well as their quality of life (DLQI) were evaluated. Clinical evaluation was performed before and after the treatment. RESULTS: The DLQI scores improved from 10.0        5.4 to 3.5        3.5 points (p   <   0.0001) and @entity3 decreased from 12.5        3.1 to 4.2        3.0 points (p   <   0.0001). The highest DLQI and @entity3 improvement was reported for the @entity1 group. Subjects reported the test dressing was better than prior therapies with 93.5% very satisfied and 90.4% satisfied. CONCLUSIONS: The @entity2 dressing is well-tolerated and effective in the treatment of inflammatory dermatoses, improving both the objective signs of the disease as well as @entity0 ' quality of life.

title: Improvement of inflammatory dermatoses severity and quality of life in XXXX treated with a betamethasone valerate plaster (LIBERE study).

answer: @entity0


abstract: The thyroid, like any other structure, may be the seat of an acute or chronic suppurative or @entity2 . @entity4 may leave their mark on the thyroid gland as well as elsewhere. @entity16 is a rare condition, usually the result of bacterial invasion of the gland. Its signs are the classic ones of @entity2 : heat, @entity6 , redness, and @entity1 , and special ones conditioned by local relationships, such as @entity9 and a desire to keep the head flexed on the chest in order to relax the paratracheal muscles. The treatment is that for any febrile disease, including specific antibiotic drugs if the invading organism has been identified and its sensitivity to the drug established. Otherwise, a broad-spectrum antibiotic may be used. Surgical drainage may be necessary and a search for a @entity3 should be made, particularly in @entity0 with @entity10 involving the left lobe. Important to differentiate from the acute @entity13 of @entity16 ( @entity16 ) is subacute (granulomatous) @entity10 ( @entity14 ) which is far more common than @entity16 and is characterized by a more protracted course, usually involving the thyroid symmetrically. The gland is also swollen and tender, and the systemic reaction may also be severe, with @entity7 and an elevated erythrocyte sedimentation rate. During the acute phase of the disorder, tests of thyroid function disclose a suppression of TSH, increased serum concentrations of T4, T3, and thyroglobulin while a diminished thyroidal RAIU is observed. The cause of @entity14 has been established in only a few instances in which a @entity11 has been the initiating factor. There may be repeated recurrences of diminishing severity. Usually, but not always, the function of the thyroid is normal after the disease has subsided. @entity14 may be treated with rest, non-steroidal anti-inflammatory drugs or @entity5 , and thyroid hormone. If the disease is severe and protracted, it is usually necessary to resort to administration of glucocorticoids, but recurrence may follow their withdrawal. It is precisely the observational nature of @entity14 therapy combined with the use of glucocorticoids which make it so critical to definitively rule out the bacterial etiology of @entity16 in the @entity0 presenting with a @entity6 thyroid. Riedel   s @entity10 is a chronic sclerosing replacement of the gland that is exceedingly rare. The process extends to adjacent structures, making any surgical intervention very difficult and potentially harmful. The exact cause of Riedel   s @entity10 remains unknown, and no specific treatment is available beyond limited resection of the thyroid gland to relieve the symptoms of tracheal or esophageal compression. The use of anti-inflammatory medical treatments has been demonstrated to have significant benefits to outcome. @entity8 may involve the thyroid, and amyloid may be deposited in the gland in quantities sufficient to cause @entity15 . In all of these diseases it may be necessary to give the @entity0 @entity12 replacement therapy if the function of the gland has been impaired.

title: Acute and Subacute, and Riedel   s XXXX

answer: @entity10


abstract: Excepting splenomegaly related to @entity3 , splenic complications observed during the course of chronic @entity7 are uncommon. These may include @entity1 , @entity8 and @entity9 . Spontaneous @entity5 is one of the least common events, a total of 29 cases being reported thus far. We present herein 4 new cases, and previously documented cases were reviewed. In our cases, the @entity9 occurred in young male @entity0 . This complication revealed the @entity6 in one case while in the others, it occurred on the average 7 months after the symptomatic onset of @entity6 . This suggests that this complication occurs early in the natural history of chronic @entity7 . The mechanism of the @entity2 remains unclear, the different causes advanced, mechanic, enzymatic or vascular, are discussed. None of our @entity0 had minimal @entity4 emphasizing the spontaneous character of @entity5 . Diagnosis was a surgical discovery except in one case in which selective arteriography was of most valuable aid in confirming diagnosis preoperatively. Treatment was simple splenectomy in 2 cases and associated with distal pancreatectomy in the 2 other cases. Recovery was uneventful. A corporal @entity8 was treated at the same time.

title: [Spontaneous @entity5 in chronic XXXX ].

answer: @entity7


abstract: Excepting splenomegaly related to @entity3 , splenic complications observed during the course of chronic @entity7 are uncommon. These may include @entity1 , @entity8 and @entity9 . Spontaneous @entity5 is one of the least common events, a total of 29 cases being reported thus far. We present herein 4 new cases, and previously documented cases were reviewed. In our cases, the @entity9 occurred in young male @entity0 . This complication revealed the @entity6 in one case while in the others, it occurred on the average 7 months after the symptomatic onset of @entity6 . This suggests that this complication occurs early in the natural history of chronic @entity7 . The mechanism of the @entity2 remains unclear, the different causes advanced, mechanic, enzymatic or vascular, are discussed. None of our @entity0 had minimal @entity4 emphasizing the spontaneous character of @entity5 . Diagnosis was a surgical discovery except in one case in which selective arteriography was of most valuable aid in confirming diagnosis preoperatively. Treatment was simple splenectomy in 2 cases and associated with distal pancreatectomy in the 2 other cases. Recovery was uneventful. A corporal @entity8 was treated at the same time.

title: [Spontaneous XXXX in chronic @entity7 ].

answer: @entity5


abstract: We report the results of chemotherapy treatment in 82 @entity0 presenting with primary digestive lymphoma and included in a study conducted between October 1977 and October 1985. There were 31 @entity8 , 18 small @entity4 , and 19 with multiple involvement: 63 @entity0 had had a surgical staging with total @entity1 resection in 15 cases. Nineteen @entity0 with limited disease ( @entity9 and IID) were randomly assigned to either a 3-week chemotherapy regimen associated with whole abdominal radiotherapy or chemotherapy for 3 years. Twenty-seven stage IIID and thirty-six stage IV were treated with chemotherapy alone for 3 years. @entity7 (16 @entity0 ) received a @entity5 , @entity6 , @entity2 association. Intermediate (56 @entity0 ) and high grade (10 @entity0 ) @entity4 received @entity5 , @entity6 , @entity3 , @entity2 . The overall complete remission obtained was 63 p. 100 (51 @entity0 ) with 17 @entity0 in relapse within 6 to 40 months. Overall survival was 46 p. 100 at 5 years. Survival was dependent on abdominal extension, histologic grade according to the new working formulation used for lymph-node @entity4 , initial localization ( @entity8 have the best survival) and achievement of complete remission. Chemotherapy is an effective treatment for primary @entity4 . The role of surgery in the management of @entity4 has to be defined by further studies.

title: [Results of a cooperative prospective study of treatment of primary digestive localizations of XXXX ].

answer: @entity7


abstract: OBJECTIVE: The objective of our study was to characterize the MRI features of @entity0 detected in augmented breasts. MATERIALS AND METHODS: A review of the MRI database identified 54 @entity1 with biopsy-proven @entity0 in augmented breasts. The images were reviewed for the type and location of the implant and for the characteristics of the @entity3 . The cases included 46 (85%) invasive @entity2 ( @entity4 , n = 35; @entity5 , n = 7; and mixed features, n = 4) and eight (15%) @entity4 in situ. RESULTS: The median age of the @entity1 at diagnosis was 49 years (range, 28-72 years). Thirty-eight of the 54 @entity2 (70%) were palpable. The mean @entity2 size was 2.8 cm (range, 0.6-9.6 cm). Of the 54 @entity2 , 34 (63%) presented as masses and 20 (37%) as nonmass enhancement on MRI. There was no detectable difference between implant position and lesion morphology (p = 0.55) or @entity2 size (p = 1.00). Twenty of 54 (37%) @entity3 abutted the implant, 13 (24%) abutted the pectoralis major muscle, and two (4%) invaded the pectoralis major muscle. Of the @entity2 abutting the implant, 18 of 20 (90%) spread along the implant capsule for more than 0.5 cm. This pattern of @entity2 spread was more common in breasts with retroglandular implants (9/16, 56%) than in those with retropectoral implants (9/38, 24%) (p = 0.03). MRI detected the index @entity3 in 16 of 54 (30%) cases, showed a greater extent of disease than was visible on mammography or ultrasound in 21 of 52 (40%) cases, and detected an unsuspected @entity3 in three of 54 (6%) cases. CONCLUSION: In augmented breasts, @entity0 often contacts either the implant or the pectoralis major muscle. @entity2 spread along the implant contour is more often seen with retroglandular implants than with retropectoral implants. MRI should be considered to assess disease extent in @entity1 with augmented breasts before surgery.

title: XXXX in Augmented Breasts: MRI Findings.

answer: @entity0


abstract: Three dermatan @entity5 (DS18, DS28, and DS35) were isolated from @entity0 's skin of ages 19 +/- 2.5, 35 +/- 3.5, 47 +/- 1.7, 60 +/- 0.8, and 75 +/- 5 years. They sequentially precipitated with 18, 28, and 35% @entity2 . Their @entity1 content was: 23.5, 25.3, and 29.0% (w/w) for DS18 at ages 19-35, 47, and 60 years, respectively; 29.0, 24.0, and 18.8% for DS28; and 18.0, 20.0, and 20.6% for DS35 at ages 19-47, 60, and 75 years, respectively. Both DS18 and DS28 decreased, respectively, from 0.030% (of wet-skin weight) to traces at age 75, and from 0.020 to 0.010% at 60 years. At age 75, DS28 apparently increased by 30%. The DS35 values (traces-0.006%) had no age-related trend. @entity4 ( @entity4 ) precipitated with 45% @entity2 , was 0.030% of skin-weight at ages 19-47, and decreased to 0.015 and 0.007% at 60 and 75 years, respectively. Its electrophoretic mobility was slower at age 47. In the oldest group, i.r. spectra of @entity4 and DS35 displayed no bands at 1650-1600, 1380, and 1320 cm-1, and a new band at 1560 cm-1. Moreover, ninhydrin-positive material of @entity4 and DS35 increased by 75 and 95%, respectively, and the reducing @entity3 content of @entity4 decreased. These data showed three chemically different dermatan @entity5 (two of which were preponderant) and N-deacetylation of @entity4 and DS35 of the oldest group. After age 47, total DS and @entity4 considerably decreased, DS18 and DS35 were oversulfated, and DS28 became undersulfated with aging.

title: Evidence for structural changes in dermatan XXXX and hyaluronic acid with aging.

answer: @entity1


abstract: UNASSIGNED: Wolbachia pipientis is a ubiquitous, maternally transmitted bacterium that infects the germline of insect hosts. Estimates are that Wolbachia infect nearly 40% of insect species on the planet, making it the most prevalent @entity2 on Earth. The bacterium, infamous for the reproductive phenotypes it induces in arthropod hosts, has risen to recent prominence due to its use in vector control. @entity2 prevents the colonization of vectors by RNA viruses, including @entity4 and important @entity0 pathogens such as @entity3 . Here we present data indicating that Wolbachia utilize the host @entity5 cytoskeleton during oogenesis for persistence within and transmission between @entity1 generations. We show that phenotypically wild type flies heterozygous for cytoskeletal mutations in @entity1 @entity6 (chic221/+ and chic1320/+) or @entity7 (qua6-396/+) either clear a @entity2 , or result in significantly reduced @entity2 levels. This reduction of Wolbachia is supported by PCR evidence, Western blot results and cytological examination. This phenotype is unlikely to be the result of maternal loading defects, defects in oocyte polarization, or germline stem cell proliferation, as the flies are phenotypically wild type in egg size, shape, and number. Importantly, however, heterozygous mutant flies exhibit decreased total G- @entity5 in the ovary, compared to control flies and chic221 heterozygous mutants exhibit decreased expression of @entity6 . Additionally, RNAi knockdown of @entity6 during development decreases Wolbachia titers. We analyze evidence in support of alternative theories to explain this Wolbachia phenotype and conclude that our results support the hypothesis that Wolbachia utilize the @entity5 skeleton for efficient transmission and maintenance within @entity1 .

title: Wolbachia Utilize Host XXXX for Efficient Maternal Transmission in @entity1 .

answer: @entity5


abstract: UNASSIGNED: Wolbachia pipientis is a ubiquitous, maternally transmitted bacterium that infects the germline of insect hosts. Estimates are that Wolbachia infect nearly 40% of insect species on the planet, making it the most prevalent @entity2 on Earth. The bacterium, infamous for the reproductive phenotypes it induces in arthropod hosts, has risen to recent prominence due to its use in vector control. @entity2 prevents the colonization of vectors by RNA viruses, including @entity4 and important @entity0 pathogens such as @entity3 . Here we present data indicating that Wolbachia utilize the host @entity5 cytoskeleton during oogenesis for persistence within and transmission between @entity1 generations. We show that phenotypically wild type flies heterozygous for cytoskeletal mutations in @entity1 @entity6 (chic221/+ and chic1320/+) or @entity7 (qua6-396/+) either clear a @entity2 , or result in significantly reduced @entity2 levels. This reduction of Wolbachia is supported by PCR evidence, Western blot results and cytological examination. This phenotype is unlikely to be the result of maternal loading defects, defects in oocyte polarization, or germline stem cell proliferation, as the flies are phenotypically wild type in egg size, shape, and number. Importantly, however, heterozygous mutant flies exhibit decreased total G- @entity5 in the ovary, compared to control flies and chic221 heterozygous mutants exhibit decreased expression of @entity6 . Additionally, RNAi knockdown of @entity6 during development decreases Wolbachia titers. We analyze evidence in support of alternative theories to explain this Wolbachia phenotype and conclude that our results support the hypothesis that Wolbachia utilize the @entity5 skeleton for efficient transmission and maintenance within @entity1 .

title: Wolbachia Utilize Host @entity5 for Efficient Maternal Transmission in XXXX .

answer: @entity1


abstract: BACKGROUND: Surveys measuring effectiveness of public awareness campaigns in reducing @entity1 ( @entity1 ) incidence have yielded equivocal findings. The aim of this study was to describe cardiovascular risk factors (CVRFs) changes over the years in an untreated population-based study. METHODS: Between 2007 and 2012, we conducted a screening campaign for CVRFs in @entity0 aged 40 to 65 yrs and @entity0 aged 50 to 70 yrs in the western suburbs of Paris. Data were complete for 20,324 @entity0 of which 14,709 were untreated. RESULTS: The prevalence trend over six years was statistically significant for @entity2 in @entity0 from 25.9% in 2007 to 21.1% in 2012 (p=0.002) and from 23% in 2007 to 12.7% in 2012 in @entity0 (p<0.0001). The prevalence trend of @entity3 smoking decreased from 38.6% to 27.7% in @entity0 (p=0.0001) and from 22.6% to 16.8% in @entity0 (p=0.113). The Framingham 10-year risk for @entity1 decreased from 13.3    8.2 % in 2007 to 11.7    9.0 % in 2012 in @entity0 and from 8.0    4.1 % to 5.9    3.4 % in @entity0 . The 10-year risk of fatal @entity1 based on the European Systematic COronary Risk Evaluation (SCORE) decreased in @entity0 and in @entity0 (p <0.0001). CONCLUSIONS: Over a 6-year period, several CVRFs have decreased in our screening campaign, leading to decrease in the 10-year risk for @entity1 and the 10-year risk of fatal @entity1 . Cardiologists should recognize the importance of community prevention programs and communication policies, particularly @entity3 control and healthier diets to decrease the CVRFs in the general population.

title: Trends in XXXX Risk Factor Prevalence and Estimated 10-Year Cardiovascular Risk Scores in a Large Untreated French Urban Population: The CARVAR 92 Study.

answer: @entity1


abstract: OBJECTIVE: To assess the causes and factors associated with the @entity1 of @entity0 between intensive care unit discharge and hospital discharge. METHODS: The present is a pilot, retrospective, observational cohort study. The records of all @entity0 admitted to two units of a public/private university hospital from February 1, 2013 to April 30, 2013 were assessed. Demographic and clinical data, risk scores and outcomes were obtained from the Epimed monitoring system and confirmed in the electronic record system of the hospital. The relative risk and respective confidence intervals were calculated. RESULTS: A total of 581 @entity0 were evaluated. The mortality rate in the intensive care unit was 20.8% and in the hospital was 24.9%. @entity2 was the cause of @entity1 in 58.3% of @entity0 who died after being discharged from the intensive care unit. Of the @entity0 from the public health system, 73 (77.6%) died in the intensive care unit and 21 (22.4%) died in the hospital after being discharged from the unit. Of the @entity0 from the Supplementary Health System, 48 (94.1%) died in the intensive care unit and 3 (5.9%) died in the hospital after being discharged from the unit (relative risk, 3.87%; 95% confidence interval, 1.21 - 12.36; p < 0.05). The post-discharge mortality rate was significantly higher in @entity0 with intensive care unit hospitalization time longer than 6 days. CONCLUSION: The main cause of @entity1 of @entity0 who were discharged from the intensive care unit and died in the ward before hospital discharge was @entity2 . Coverage by the public healthcare system and longer hospitalization time in the intensive care unit were factors associated with @entity1 after discharge from the intensive care unit.

title: @entity2 : a major cause of hospital XXXX after intensive care unit discharge.

answer: @entity1


abstract: OBJECTIVE: To assess the causes and factors associated with the @entity1 of @entity0 between intensive care unit discharge and hospital discharge. METHODS: The present is a pilot, retrospective, observational cohort study. The records of all @entity0 admitted to two units of a public/private university hospital from February 1, 2013 to April 30, 2013 were assessed. Demographic and clinical data, risk scores and outcomes were obtained from the Epimed monitoring system and confirmed in the electronic record system of the hospital. The relative risk and respective confidence intervals were calculated. RESULTS: A total of 581 @entity0 were evaluated. The mortality rate in the intensive care unit was 20.8% and in the hospital was 24.9%. @entity2 was the cause of @entity1 in 58.3% of @entity0 who died after being discharged from the intensive care unit. Of the @entity0 from the public health system, 73 (77.6%) died in the intensive care unit and 21 (22.4%) died in the hospital after being discharged from the unit. Of the @entity0 from the Supplementary Health System, 48 (94.1%) died in the intensive care unit and 3 (5.9%) died in the hospital after being discharged from the unit (relative risk, 3.87%; 95% confidence interval, 1.21 - 12.36; p < 0.05). The post-discharge mortality rate was significantly higher in @entity0 with intensive care unit hospitalization time longer than 6 days. CONCLUSION: The main cause of @entity1 of @entity0 who were discharged from the intensive care unit and died in the ward before hospital discharge was @entity2 . Coverage by the public healthcare system and longer hospitalization time in the intensive care unit were factors associated with @entity1 after discharge from the intensive care unit.

title: XXXX : a major cause of hospital @entity1 after intensive care unit discharge.

answer: @entity2


abstract: OBJECTIVE: To test ex vivo mechanical properties of 4 allograft fixation techniques for cranial cruciate ligament (CCL) replacement. SAMPLE: 30 stifle joints from @entity1 cadavers. PROCEDURES: @entity0 repaired by 1 of 4 techniques (n = 6/group) and @entity0 (control group; 6) were mechanically tested. Three repair techniques involved a patella-patella ligament segment (PPL) allograft: a tibial and femoral interference screw (PPL-2S), a femoral interference screw and the patella seated in a tapering bone tunnel in the tibia (PPL-1S), or addition of a suture and a bone anchor to the PPL-1S (PPL-SL). The fourth technique involved a @entity2 ( @entity2 ) allograft secured with transverse femoral fixation and stabilized with a tibial interference screw and 2 spiked washers on the tibia ( @entity2 -TF). The tibia was axially loaded at a joint angle of 135  . Loads to induce 3, 5, and 10 mm of femoral-tibia translation; stiffness; and load at ultimate failure with the corresponding displacement were calculated. Group means were compared with a multivariate ANOVA. RESULTS: Mean    SD load for the intact (control) CCL was 520.0    51.3 N and did not differ significantly from the load needed to induce 3 mm of femoral-tibial translation for fixation techniques PPL-SL (422.4    46.3 N) and @entity2 -TF (654.2    117.7 N). Results for the @entity2 -TF were similar to those of the intact CCL for all outcome measures. CONCLUSIONS AND CLINICAL RELEVANCE: The @entity2 -TF yielded mechanical properties similar to those of intact CCLs and may be a viable technique to test in vivo.

title: Mechanical strength of four allograft fixation techniques for ruptured cranial cruciate ligament repair in XXXX .

answer: @entity1


abstract: UNASSIGNED: Hexokinase II is responsible for the first step in the glycolysis pathway by adding a @entity7 onto the @entity1 molecule so it can proceed down the pathway to produce the energy for continuous @entity0 cell growth. @entity0 cells overexpress the hexokinase II enzyme. In fact, it is the overexpression of the hexokinase II enzyme that makes the diagnosis of @entity0 possible when imaged by positron emission tomography (PET). Hexokinase II binds to the voltage-dependent anion channel (VDAC) located on the mitochondrial outer membrane (MOM). When bound to the MOM, hexokinase II is blocking a major cell death pathway. Thus, hexokinase II is responsible for two characteristics of @entity0 cells, rapid @entity0 growth and @entity0 cells to undergo apoptosis. One method to identify novel compounds that may interfere with the hexokinase II-VDAC binding site is to create a molecular model using the crystal structure of hexokinase II. However, the @entity5 (s) responsible for hexokinase II binding to VDAC are not known. Therefore, a series of truncations and point mutations were made to the @entity2 -terminal end of hexokinase II to identify the binding site to VDAC. Deletions of the first 10 and 20 @entity4 indicated that important @entity5 (s) for binding were located within the first 10 @entity4 . Next, a series of point mutations were made within the first 10 @entity4 . It is clear from the immunofluorescence images and immunoblot results that mutating the fifth @entity5 from @entity6 to @entity3 completely abolished binding to the MOM.

title: Identification of a Mitochondrial-Binding Site on the XXXX -Terminal End of Hexokinase II.

answer: @entity2


abstract: UNASSIGNED: OBJECT Awake craniotomy is currently a useful surgical approach to help identify and preserve functional areas during cortical and subcortical @entity1 resections. Methodologies have evolved over time to maximize @entity0 safety and minimize morbidity using this technique. The goal of this study is to analyze a single surgeon's experience and the evolving methodology of awake language and sensorimotor mapping for @entity2 surgery. METHODS The authors retrospectively studied @entity0 undergoing awake @entity9 surgery between 1986 and 2014. Operations for the initial 248 @entity0 (1986-1997) were completed at the University of Washington, and the subsequent surgeries in 611 @entity0 (1997-2014) were completed at the University of California, San Francisco. Perioperative risk factors and complications were assessed using the latter 611 cases. RESULTS The median @entity0 age was 42 years (range 13-84 years). Sixty percent of @entity0 had @entity5 ( @entity5 ) scores of 90-100, and 40% had @entity5 scores less than 80. Fifty-five percent of @entity0 underwent surgery for high-grade @entity2 , 42% for low-grade @entity2 , 1% for metastatic lesions, and 2% for other lesions ( @entity14 , @entity6 , @entity3 , abscess, and @entity13 ). The majority of @entity0 were in American Society of Anesthesiologists (ASA) Class 1 or 2 (mild @entity7 ); however, @entity0 with severe @entity7 were not excluded from awake @entity9 surgery and represented 15% of study @entity0 . Laryngeal mask airway was used in 8 @entity0 (1%) and was most commonly used for large @entity1 with more than 2 cm of mass effect. The most common sedation regimen was @entity10 plus @entity11 (54%); however, 42% of @entity0 required an adjustment to the initial sedation regimen before skin incision due to @entity0 intolerance. @entity12 was used in 54% of cases. Twelve percent of @entity0 were active smokers at the time of surgery, which did not impact completion of the intraoperative mapping procedure. Stimulation-induced @entity8 occurred in 3% of @entity0 and were rapidly terminated with ice-cold Ringer's solution. Preoperative @entity8 history and @entity1 location were associated with an increased incidence of stimulation-induced @entity8 . Mapping was aborted in 3 cases (0.5%) due to intraoperative @entity8 (2 cases) and @entity0 emotional intolerance (1 case). The overall perioperative complication rate was 10%. CONCLUSIONS Based on the current best practice described here and developed from multiple regimens used over a 27-year period, it is concluded that awake @entity9 surgery can be safely performed with extremely low complication and failure rates regardless of ASA classification; body mass index; smoking status; @entity4 or emotional history; @entity8 frequency and duration; and @entity1 site, size, and pathology.

title: Awake craniotomy to maximize XXXX resection: methods and technical nuances over a 27-year period.

answer: @entity2


abstract: @entity3 , the most common form of @entity4 , influences a @entity0 's mental well-being, ability to work or perform activities of daily living, and personal and family relationships. Ideally, the management of this disease is multidisciplinary, involving not only the use of medication but also exercise instruction, dietary counseling, and psychosocial interventions. The effects of such a comprehensive treatment program have not been well studied. A 12-week trial of multidisciplinary assessment and management of @entity3 was conducted. In addition to receiving the anti-inflammatory agent sulindac, @entity0 were evaluated and followed up by health professionals in the disciplines of medicine, physical therapy, occupational therapy, nutrition, social work, and psychology. An initial assessment of the degree of @entity2 , @entity1 , @entity5 , stiffness, and ability to conduct activities of daily living was made, which represented @entity0 ' entry status. Subsequent assessments were made by the multidisciplinary team every two weeks for 12 weeks. Seventy-seven @entity0 completed at least ten of the 12 weeks. On entering the study, two thirds of the @entity0 had @entity2 , @entity5 , or @entity1 affecting the hip, knee, or hand. At the end of 12 weeks, 80% of the @entity0 had improvement in their @entity3 , and 71% improved in their ability to conduct activities of daily living. The results support the view that a comprehensive @entity3 can significantly reduce disability and @entity2 .

title: Medical aspects of the multidisciplinary assessment and management of XXXX .

answer: @entity3


abstract: Introduction. While the incidence of @entity4 has steadily increased, we sought to evaluate the changes in their surgical management. Methods. @entity0 with @entity4 who underwent surgical resection from 2003 to 2013 were identified. Clinicopathologic factors were analyzed and compared to a similar cohort from 1992 to 2002. Results. There were 134 @entity0 with @entity4 who underwent surgical resection from 2003 to 2013, compared to 73 from 1992 to 2002. The most common preoperative imaging was a CT scan, although 66% underwent EUS and 63% underwent biopsy. Pathology included 18 serous, 47 mucinous, 11 pseudopapillary, and 58 @entity6 ( @entity6 ). In comparing cohorts, there were significantly fewer @entity2 and more @entity6 . @entity3 rates were similar, and perioperative mortality rates were comparable. Conclusion. There has been a dramatic change in surgically treated @entity5 over the past two decades. Our data suggests that the incorporation of new imaging and diagnostic tests has led to greater detection of @entity1 and a decreased rate of potentially unnecessary resections. Therefore, all @entity0 with cystic @entity4 should undergo a focused @entity5 , and an EUS biopsy should be considered, in order to best select those that would benefit from surgical resection.

title: The changing spectrum of surgically treated XXXX .

answer: @entity5


abstract: Purpose. The aim of this study was to determine the efficacy of prophylactic antibiotics (PA) for reducing the @entity2 and the potential risk factors responsible for the @entity2 after stent insertion for malignant @entity1 . Methods. We performed a retrospective review of 224 @entity0 who underwent self-expandable metallic stent (SEMS) insertion for malignant @entity1 from May 2004 to December 2012. Results. There were 145 @entity0 in the PA group and 79 in non-PA group. The @entity4 level in PA group was significantly higher than that in non-PA. Abdominal tenderness and mechanical ileus were significantly more frequent in PA group than those in non-PA. The frequency of post-SEMS insertion fever, @entity3 ( @entity3 ), and @entity5 was not significantly different between PA and non-PA groups. In multivariate analysis, the @entity4 level was risk factor related to post-SEMS insertion @entity3 . However, in propensity score matching analysis, there was no independent risk factor related to post-SEMS insertion fever, @entity3 , and @entity5 . Conclusion. The use of PA in @entity0 with malignant @entity1 may be not effective to prevent the development of @entity2 after SEMS insertion.

title: Clinical impact of prophylactic antibiotic treatment for self-expandable metallic stent insertion in @entity0 with malignant XXXX .

answer: @entity1


abstract: Purpose. The aim of this study was to determine the efficacy of prophylactic antibiotics (PA) for reducing the @entity2 and the potential risk factors responsible for the @entity2 after stent insertion for malignant @entity1 . Methods. We performed a retrospective review of 224 @entity0 who underwent self-expandable metallic stent (SEMS) insertion for malignant @entity1 from May 2004 to December 2012. Results. There were 145 @entity0 in the PA group and 79 in non-PA group. The @entity4 level in PA group was significantly higher than that in non-PA. Abdominal tenderness and mechanical ileus were significantly more frequent in PA group than those in non-PA. The frequency of post-SEMS insertion fever, @entity3 ( @entity3 ), and @entity5 was not significantly different between PA and non-PA groups. In multivariate analysis, the @entity4 level was risk factor related to post-SEMS insertion @entity3 . However, in propensity score matching analysis, there was no independent risk factor related to post-SEMS insertion fever, @entity3 , and @entity5 . Conclusion. The use of PA in @entity0 with malignant @entity1 may be not effective to prevent the development of @entity2 after SEMS insertion.

title: Clinical impact of prophylactic antibiotic treatment for self-expandable metallic stent insertion in XXXX with malignant @entity1 .

answer: @entity0


abstract: INTRODUCTION: @entity10 is relatively rare cause of @entity8 which is often accompanied by severe @entity11 . @entity7 replacement therapy is essential for this condition, but gastrointestinal symptom such as @entity2 and @entity3 is not well-recognized adverse effect of @entity7 . CASE DESCRIPTION: A 64-year-old- @entity0 was referred to our hospital because of frequent severe @entity11 . She was diagnosed as type 2 @entity1 when she was 58 years old but had not been treated since she was 60. We ruled out the possibility of exogenous administration of insulin or other anti- @entity1 drugs, @entity9 . After @entity4 injection, she once became conscious, but severe @entity11 was often observed even after that. In addition, counter-regulatory hormone levels were not increased even at the time of @entity11 . We conducted several hormone load tests. In @entity12 ( @entity12 ) load test, excess and delayed reaction of ACTH was observed. In @entity13 (TRH) load test, TSH and prolactin were normally secreted in response to TRH. In luteinizing hormone-releasing hormone (LHRH) load test, delayed reaction of LH and FSH was observed. Based on such hormone loading tests, we diagnosed this @entity0 as @entity10 and consequent @entity8 . We immediately intravenously injected @entity7 and started oral @entity7 therapy. However, just after taking @entity7 , @entity3 was often observed which disturbed sufficient @entity5 hormone replacement, leading to recurrent @entity11 . Therefore, we stopped @entity7 and instead started an alternative treatment with @entity6 . After that, @entity3 and @entity11 were not observed at all. DISCUSSION AND EVALUATION: We diagnosed this subject as @entity10 mainly by the following two findings: (1) excess and delayed reaction of ACTH in @entity12 load test, (2) delayed reaction of LH and FSH in LHRH load test. CONCLUSIONS: We should be aware of the possibility of @entity10 as a cause of recurrent severe @entity11 . Also, we should be aware that @entity7 could induce gastrointestinal symptom and that in such a case we should stop @entity7 and start @entity6 to sufficiently replace @entity5 hormone and avoid recurrent @entity11 .

title: A case of XXXX accompanied by recurrent severe @entity11 .

answer: @entity10


abstract: INTRODUCTION: @entity10 is relatively rare cause of @entity8 which is often accompanied by severe @entity11 . @entity7 replacement therapy is essential for this condition, but gastrointestinal symptom such as @entity2 and @entity3 is not well-recognized adverse effect of @entity7 . CASE DESCRIPTION: A 64-year-old- @entity0 was referred to our hospital because of frequent severe @entity11 . She was diagnosed as type 2 @entity1 when she was 58 years old but had not been treated since she was 60. We ruled out the possibility of exogenous administration of insulin or other anti- @entity1 drugs, @entity9 . After @entity4 injection, she once became conscious, but severe @entity11 was often observed even after that. In addition, counter-regulatory hormone levels were not increased even at the time of @entity11 . We conducted several hormone load tests. In @entity12 ( @entity12 ) load test, excess and delayed reaction of ACTH was observed. In @entity13 (TRH) load test, TSH and prolactin were normally secreted in response to TRH. In luteinizing hormone-releasing hormone (LHRH) load test, delayed reaction of LH and FSH was observed. Based on such hormone loading tests, we diagnosed this @entity0 as @entity10 and consequent @entity8 . We immediately intravenously injected @entity7 and started oral @entity7 therapy. However, just after taking @entity7 , @entity3 was often observed which disturbed sufficient @entity5 hormone replacement, leading to recurrent @entity11 . Therefore, we stopped @entity7 and instead started an alternative treatment with @entity6 . After that, @entity3 and @entity11 were not observed at all. DISCUSSION AND EVALUATION: We diagnosed this subject as @entity10 mainly by the following two findings: (1) excess and delayed reaction of ACTH in @entity12 load test, (2) delayed reaction of LH and FSH in LHRH load test. CONCLUSIONS: We should be aware of the possibility of @entity10 as a cause of recurrent severe @entity11 . Also, we should be aware that @entity7 could induce gastrointestinal symptom and that in such a case we should stop @entity7 and start @entity6 to sufficiently replace @entity5 hormone and avoid recurrent @entity11 .

title: A case of @entity10 accompanied by recurrent severe XXXX .

answer: @entity11


abstract: @entity3 occurred in 53 (22 percent) of 236 consecutive @entity0 undergoing pneumonectomy. All @entity0 had preoperative electrocardiograms which showed normal sinus rhythm. @entity0 did not receive digitalis before surgery. @entity5 was the most common @entity4 (64 percent; 34/53), followed by @entity9 (23 percent; 12/53) and @entity6 (13 percent; 7/53). No episodes of @entity7 were documented. Elevated concentrations of cardiac enzymes were associated with 12 (28 percent) of 43 tachydysrhythmias. Recurrent or persistent @entity4 were documented in 29 (55 percent) of 53 @entity0 despite medical management or electrocardioversion (or both). Thirty-one percent (9/29) of these @entity0 subsequently died during their hospitalization. There was no correlation between standard preoperative pulmonary function tests and the incidence of @entity2 . In addition, there was no correlation of @entity4 with postoperative diagnoses, surgical staging for @entity1 , postoperative arterial blood gas levels, or the fact that a completion pneumonectomy or chest wall resection was undertaken. An increased incidence of tachydysrhythmia was noted in @entity0 undergoing intrapericardial dissections and those who developed postoperative interstitial or perihilar @entity8 . Twenty-five percent (13) of the @entity0 experiencing tachydysrhythmias died within 30 days following their pneumonectomy. We conclude that tachydysrhythmias after pneumonectomy are associated with significant mortality, have poor correlation to preoperative pulmonary function, and occur more frequently following intrapericardial dissection and in @entity0 who develop postoperative @entity8 or perihilar @entity8 .

title: XXXX following pneumonectomy. Clinical correlates and prognostic significance.

answer: @entity4


abstract: OBJECTIVES: Substance use disorder is characterized by impaired decision @entity3 , impulsivity, and risk taking. @entity4 shares many of these characteristics, and having both diagnoses may be associated with greater problems than either diagnosis alone. We investigated whether among substance-dependent individuals, comorbid @entity4 would be associated with worse decision @entity3 , greater impulsivity, risk taking, and drug severity. METHODS: Ninety-six substance-dependent individuals were recruited from a residential treatment program and divided into 1 of the 2 groups depending on whether they met Diagnostic and Statistical Manual of @entity1 , Fourth Edition, criteria for @entity4 (SDPG, n = 26) or not (SD, n = 70). Ninety-two controls were recruited from the community. @entity0 completed a decision- @entity3 task (modified Iowa Gambling Task), measures of impulsivity (Barratt Impulsivity Scale and Delay Discounting), and risk taking (Balloon Analog Risk Task). Decision @entity3 was analyzed using a computational model. We tested for group differences using analysis of covariance or Kruskal-Wallis and appropriate post-hoc tests. RESULTS: The groups differed in decision- @entity3 parameters (P < 0.001) and self-reported impulsivity (P < 0.001). All post-hoc comparisons were significant on these measures, and indicated stepwise changes in controls, followed by SD, followed by SDPG, with SDPG performing worse on decision @entity3 and being more impulsive. Compared with SD, SDPG had greater drug severity (P < 0.001). No group differences were observed in delay discounting or risk taking. CONCLUSIONS: Compared with individuals with @entity2 without @entity4 , those with both disorders demonstrated worse decision @entity3 and significantly more drug-related symptoms. When evaluating @entity0 with @entity2 , clinicians should consider diagnostic assessments for gambling, as the co-occurrence of both disorders may impact clinical characteristics.

title: Impaired Decision-Making, Higher Impulsivity, and Drug Severity in @entity2 and XXXX .

answer: @entity4


abstract: OBJECTIVES: Substance use disorder is characterized by impaired decision @entity3 , impulsivity, and risk taking. @entity4 shares many of these characteristics, and having both diagnoses may be associated with greater problems than either diagnosis alone. We investigated whether among substance-dependent individuals, comorbid @entity4 would be associated with worse decision @entity3 , greater impulsivity, risk taking, and drug severity. METHODS: Ninety-six substance-dependent individuals were recruited from a residential treatment program and divided into 1 of the 2 groups depending on whether they met Diagnostic and Statistical Manual of @entity1 , Fourth Edition, criteria for @entity4 (SDPG, n = 26) or not (SD, n = 70). Ninety-two controls were recruited from the community. @entity0 completed a decision- @entity3 task (modified Iowa Gambling Task), measures of impulsivity (Barratt Impulsivity Scale and Delay Discounting), and risk taking (Balloon Analog Risk Task). Decision @entity3 was analyzed using a computational model. We tested for group differences using analysis of covariance or Kruskal-Wallis and appropriate post-hoc tests. RESULTS: The groups differed in decision- @entity3 parameters (P < 0.001) and self-reported impulsivity (P < 0.001). All post-hoc comparisons were significant on these measures, and indicated stepwise changes in controls, followed by SD, followed by SDPG, with SDPG performing worse on decision @entity3 and being more impulsive. Compared with SD, SDPG had greater drug severity (P < 0.001). No group differences were observed in delay discounting or risk taking. CONCLUSIONS: Compared with individuals with @entity2 without @entity4 , those with both disorders demonstrated worse decision @entity3 and significantly more drug-related symptoms. When evaluating @entity0 with @entity2 , clinicians should consider diagnostic assessments for gambling, as the co-occurrence of both disorders may impact clinical characteristics.

title: Impaired Decision-Making, Higher Impulsivity, and Drug Severity in XXXX and @entity4 .

answer: @entity2


abstract: Bone morphogenetic proteins (BMPs), members of the TGF-b superfamily, have numerous biological activities including control of growth, differentiation, and vascular development. Using an in vitro co-culture endothelial cord formation assay, we investigated the role of a @entity7 variant (BMP7v) in @entity1 , @entity4 , and @entity0 -driven angiogenesis. BMP7v treatment led to disruption of neo-endothelial cord formation and regression of existing @entity1 and @entity4 cords in vitro. Using a series of @entity0 cell models capable of driving angiogenesis in vitro, BMP7v treatment completely blocked cord formation. Pre-treatment of endothelial cells with BMP7v significantly reduced their cord forming ability, indicating a direct effect on endothelial cell function. BMP7v activated the canonical SMAD signaling pathway in endothelial cells but targeted gene knockdown using shRNA directed against @entity5 suggests this pathway is not required to mediate the anti-angiogenic effect. In contrast to SMAD activation, BMP7v selectively decreased ERK and AKT activation, significantly decreased endothelial cell migration and down-regulated expression of critical RTKs involved in @entity1 and FGF angiogenic signaling, @entity2 and @entity6 respectively. Importantly, in an in vivo angiogenic plug assay that serves as a measurement of angiogenesis, BMP7v significantly decreased hemoglobin content indicating inhibition of neoangiogenesis. In addition, BMP7v significantly decreased angiogenesis in @entity3 stem-like cell (GSLC) Matrigel plugs and significantly impaired in vivo growth of a GSLC xenograft with a concomitant reduction in microvessel density. These data support BMP7v as a potent anti-angiogenic molecule that is effective in the context of @entity0 angiogenesis.

title: A XXXX Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology.

answer: @entity7


abstract: The long-term outcome of @entity1 was reviewed in 139 @entity0 who were treated at the Cleveland Clinic for a minimum of 15 years. At the time of diagnosis, 38 (27 percent), 39 (28 percent) and 62 (43 percent) @entity0 had small-bowel, large-bowel, and ileocolic patterns of disease, respectively. The disease progressed with time and, eventually, 104 (75 percent) @entity0 had @entity1 . One hundred twenty-two @entity0 (88 percent) underwent at least one definitive operation for the disease. Forty-four (32 percent) @entity0 had proctocolectomies and 65 (47 percent) have ileostomies. Associated manifestations of @entity1 occurred in a high proportion of @entity0 ; perianal disease in 78 (56 percent), intestinal fistulas in 45 (32 percent), extraintestinal disease in 49 (35 percent). Six @entity0 died of causes directly related to the disease. Specific complications tend to occur at definite times in the course of the disease. @entity1 is not a benign condition. There is a relentless progression of the disease and a high incidence of complications when @entity0 are followed over a long period.

title: The long-term outcome in XXXX .

answer: @entity1


abstract: PURPOSE: To evaluate the correlation between maximum standardized uptake value (SUVmax ) and minimum apparent diffusion coefficient (ADCmin ) of @entity3 derived from an integrated positron emission tomography / magnetic resonance (PET/MR) system and to determine their correlation with pathological prognostic factors. MATERIALS AND METHODS: This prospective study was approved by the Institutional Review Board of the hospital, and informed consent was obtained. Between April and December 2014, 47 consecutive @entity0 with @entity3 were enrolled and underwent simultaneous PET/MR examinations before surgery. Thirty-six @entity0 with measurable @entity2 on PET/MR were included for image analysis. Pearson's correlation coefficient was used to evaluate the correlation between SUVmax and ADCmin of the @entity2 . The Mann-Whitney U-test was utilized to evaluate relationships between these two imaging biomarkers and pathological prognostic factors. RESULTS: The mean SUVmax and ADCmin were 14.7        7.1 and 0.48        0.13 * 10(-3) mm(2) /s, respectively. A significant inverse correlation was found between SUVmax and ADCmin (r   =   -0.53; P   =   0.001). SUVmax was significantly higher in @entity2 with advanced stage, deep @entity1 , cervical invasion, lymphovascular space involvement, and lymph node @entity1 (P   <   0.05). ADCmin was lower in @entity2 with higher grade, advanced stage, and cervical invasion (P   <   0.05). The ratio of SUVmax to ADCmin was higher in @entity2 with higher grade, advanced stage, deep @entity1 , cervical invasion, lymphovascular space involvement, and lymph node @entity1 (P   <   0.05). CONCLUSION: SUVmax and ADCmin of @entity3 derived from integrated PET/MR are inversely correlated and are associated with pathological prognostic factors.

title: Standardized uptake value and apparent diffusion coefficient of XXXX evaluated with integrated whole-body PET/MR: Correlation with pathological prognostic factors.

answer: @entity3