abstract: A 2-year-old, female spayed Golden Retriever @entity3 was presented to The Ohio State University Veterinary Medical Center for evaluation of @entity8 , @entity1 , 1 episode of @entity7 , dull mentation, and inappetence. Physical examination revealed an elevated temperature of 39.7  C and severe @entity1 . Blood work revealed a mature neutrophilia. Cerebrospinal fluid (CSF) analysis revealed nondegenerative neutrophilic pleocytosis with no infectious agents. A presumptive diagnosis of @entity5 -responsive @entity6 - @entity10 was made, and @entity2 therapy was started. The @entity0 improved initially but experienced a vestibular episode characterized by falling and @entity4 . A magnetic resonance imaging of the brain revealed an @entity11 in the cervical vertebral canal and diffuse meningeal enhancement in the brain and cranial cervical spine. Abscess drainage revealed degenerate neutrophils and several filamentous, branching organisms. Culture of the initial CSF using an enrichment broth revealed growth of a Gram-positive organism 5 days after fluid collection. The isolate was identified by partial 16S ribosomal DNA sequencing as Actinomyces spp. The @entity0 was successfully treated with long-term antibiotics. Our study reports the long-term survival after medical treatment of @entity9 and epidural abscessation due to Actinomyces sp. infection in a @entity3 . @entity9 should be included as a differential diagnosis in @entity0 with cervical @entity1 , even when a nondegenerative neutrophilic pleocytosis is found on CSF analysis. Culture of the CSF with use of an enrichment broth should be considered in all cases of neutrophilic pleocytosis to rule out infections of the central nervous system.

title: Long-term survival in a XXXX with meningoencephalitis and epidural abscessation due to Actinomyces species.

answer: @entity3


abstract: AIMS: We investigated the association between @entity1 duration and the extent and severity of @entity3 ( @entity3 ) as well as long-term clinical outcomes using coronary computed tomography angiography (CCTA) in asymptomatic type 2 @entity1 @entity0 . METHODS AND RESULTS: We analysed 933 asymptomatic type 2 @entity1 @entity0 without known @entity3 who underwent CCTA. @entity0 were divided into three groups according to the duration of @entity1 : <5 years, 5-10 years, and >= 10 years. Stenosis by CCTA was scored as none (0%), non-obstructive (1-49%), or obstructive (>= 50%) for each coronary artery segment. For these @entity0 , we compared the prevalence, extent, and severity of @entity3 , including coronary artery @entity4 score (CACS), @entity7 burden obstructive score (ABOS), segment involvement score (SIS), and segment @entity6 score (SSS). Major adverse cardiac and cerebrovascular events (MACCE), including all-cause mortality, non-fatal @entity5 , and @entity2 , within a follow-up period were also compared. @entity0 with longer duration of @entity1 possessed higher rates of obstructive @entity3 (P < 0.001). @entity0 with longer duration of @entity1 also manifested greater degree of CACS, ABOS, SIS, and SSS (P < 0.001 for all) with associated higher rate of MACCE (P = 0.025). Presence of obstructive @entity3 as assessed by CCTA was an independent predictor of MACCE after adjusting for confounding risk factors (hazard ratio: 1.979, confidence interval: 1.178-3.327, P = 0.010). CONCLUSION: In asymptomatic @entity1 @entity0 , longer @entity1 duration is associated with a higher prevalence, extent, and severity of @entity3 as well as risk of MACCE. Moreover, greater @entity3 burden increases the risk of MACCE independent of co-existing @entity3 risk factors.

title: Impact of @entity1 duration on the extent and severity of coronary atheroma burden and long-term clinical outcome in asymptomatic type 2 XXXX @entity0 : evaluation by Coronary CT angiography.

answer: @entity1


abstract: AIMS: We investigated the association between @entity1 duration and the extent and severity of @entity3 ( @entity3 ) as well as long-term clinical outcomes using coronary computed tomography angiography (CCTA) in asymptomatic type 2 @entity1 @entity0 . METHODS AND RESULTS: We analysed 933 asymptomatic type 2 @entity1 @entity0 without known @entity3 who underwent CCTA. @entity0 were divided into three groups according to the duration of @entity1 : <5 years, 5-10 years, and >= 10 years. Stenosis by CCTA was scored as none (0%), non-obstructive (1-49%), or obstructive (>= 50%) for each coronary artery segment. For these @entity0 , we compared the prevalence, extent, and severity of @entity3 , including coronary artery @entity4 score (CACS), @entity7 burden obstructive score (ABOS), segment involvement score (SIS), and segment @entity6 score (SSS). Major adverse cardiac and cerebrovascular events (MACCE), including all-cause mortality, non-fatal @entity5 , and @entity2 , within a follow-up period were also compared. @entity0 with longer duration of @entity1 possessed higher rates of obstructive @entity3 (P < 0.001). @entity0 with longer duration of @entity1 also manifested greater degree of CACS, ABOS, SIS, and SSS (P < 0.001 for all) with associated higher rate of MACCE (P = 0.025). Presence of obstructive @entity3 as assessed by CCTA was an independent predictor of MACCE after adjusting for confounding risk factors (hazard ratio: 1.979, confidence interval: 1.178-3.327, P = 0.010). CONCLUSION: In asymptomatic @entity1 @entity0 , longer @entity1 duration is associated with a higher prevalence, extent, and severity of @entity3 as well as risk of MACCE. Moreover, greater @entity3 burden increases the risk of MACCE independent of co-existing @entity3 risk factors.

title: Impact of XXXX duration on the extent and severity of coronary atheroma burden and long-term clinical outcome in asymptomatic type 2 @entity1 @entity0 : evaluation by Coronary CT angiography.

answer: @entity1


abstract: AIMS: We investigated the association between @entity1 duration and the extent and severity of @entity3 ( @entity3 ) as well as long-term clinical outcomes using coronary computed tomography angiography (CCTA) in asymptomatic type 2 @entity1 @entity0 . METHODS AND RESULTS: We analysed 933 asymptomatic type 2 @entity1 @entity0 without known @entity3 who underwent CCTA. @entity0 were divided into three groups according to the duration of @entity1 : <5 years, 5-10 years, and >= 10 years. Stenosis by CCTA was scored as none (0%), non-obstructive (1-49%), or obstructive (>= 50%) for each coronary artery segment. For these @entity0 , we compared the prevalence, extent, and severity of @entity3 , including coronary artery @entity4 score (CACS), @entity7 burden obstructive score (ABOS), segment involvement score (SIS), and segment @entity6 score (SSS). Major adverse cardiac and cerebrovascular events (MACCE), including all-cause mortality, non-fatal @entity5 , and @entity2 , within a follow-up period were also compared. @entity0 with longer duration of @entity1 possessed higher rates of obstructive @entity3 (P < 0.001). @entity0 with longer duration of @entity1 also manifested greater degree of CACS, ABOS, SIS, and SSS (P < 0.001 for all) with associated higher rate of MACCE (P = 0.025). Presence of obstructive @entity3 as assessed by CCTA was an independent predictor of MACCE after adjusting for confounding risk factors (hazard ratio: 1.979, confidence interval: 1.178-3.327, P = 0.010). CONCLUSION: In asymptomatic @entity1 @entity0 , longer @entity1 duration is associated with a higher prevalence, extent, and severity of @entity3 as well as risk of MACCE. Moreover, greater @entity3 burden increases the risk of MACCE independent of co-existing @entity3 risk factors.

title: Impact of @entity1 duration on the extent and severity of coronary atheroma burden and long-term clinical outcome in asymptomatic type 2 @entity1 XXXX : evaluation by Coronary CT angiography.

answer: @entity0


abstract: BACKGROUND: @entity2 is a significant cause of morbidity and mortality in the elderly and an important public health issue. @entity3 are the primary treatment options for @entity2 . The oral administration of @entity3 may result in poor @entity0 compliance and thence reduced treatment efficacy. Intravenously administered @entity3 may therefore show better treatment efficacy. We have carried out a meta-analysis to evaluate the efficacy of @entity6 treatment for @entity2 in both @entity0 and @entity0 with either @entity5 . MATERIAL AND METHODS: Randomized controlled trials with @entity6 treatment for @entity2 were retrieved from PubMed, EMBASE and clinicaltrials.gov. The risk ratio with 95% confidence interval (RR, 95% CI) was calculated to evaluate the effect of @entity6 treatment on incidence of @entity5 . Data on changes in @entity1 ( @entity1 ) following @entity6 ( @entity7 ) treatment was also extracted. STATA software was used for all the statistical analyses. RESULTS: Significant reduction in the incidence of both vertebral and nonvertebral @entity5 was observed following @entity7 treatment, as seen from the values for RR with 95% CI (RR 0.24 and 95% CI 0.15 to 0.40 for @entity5 ; RR 0.76 and 95% CI 0.67 to 0.86 for @entity5 ). @entity1 was also seen to be increased after @entity7 treatment. CONCLUSION: Ourmeta-analysis showed that @entity6 was effective in reducing the incidence of @entity5 as well as @entity5 , including @entity4 . Significant increase in @entity1 ( @entity1 ) was also observed in @entity0 administered @entity7 as compared to placebo.

title: Efficacy of @entity6 in treatment of XXXX in @entity0 and @entity0 -a meta-analysis.

answer: @entity2


abstract: BACKGROUND: @entity2 is a significant cause of morbidity and mortality in the elderly and an important public health issue. @entity3 are the primary treatment options for @entity2 . The oral administration of @entity3 may result in poor @entity0 compliance and thence reduced treatment efficacy. Intravenously administered @entity3 may therefore show better treatment efficacy. We have carried out a meta-analysis to evaluate the efficacy of @entity6 treatment for @entity2 in both @entity0 and @entity0 with either @entity5 . MATERIAL AND METHODS: Randomized controlled trials with @entity6 treatment for @entity2 were retrieved from PubMed, EMBASE and clinicaltrials.gov. The risk ratio with 95% confidence interval (RR, 95% CI) was calculated to evaluate the effect of @entity6 treatment on incidence of @entity5 . Data on changes in @entity1 ( @entity1 ) following @entity6 ( @entity7 ) treatment was also extracted. STATA software was used for all the statistical analyses. RESULTS: Significant reduction in the incidence of both vertebral and nonvertebral @entity5 was observed following @entity7 treatment, as seen from the values for RR with 95% CI (RR 0.24 and 95% CI 0.15 to 0.40 for @entity5 ; RR 0.76 and 95% CI 0.67 to 0.86 for @entity5 ). @entity1 was also seen to be increased after @entity7 treatment. CONCLUSION: Ourmeta-analysis showed that @entity6 was effective in reducing the incidence of @entity5 as well as @entity5 , including @entity4 . Significant increase in @entity1 ( @entity1 ) was also observed in @entity0 administered @entity7 as compared to placebo.

title: Efficacy of XXXX in treatment of @entity2 in @entity0 and @entity0 -a meta-analysis.

answer: @entity6


abstract: BACKGROUND: @entity2 is a significant cause of morbidity and mortality in the elderly and an important public health issue. @entity3 are the primary treatment options for @entity2 . The oral administration of @entity3 may result in poor @entity0 compliance and thence reduced treatment efficacy. Intravenously administered @entity3 may therefore show better treatment efficacy. We have carried out a meta-analysis to evaluate the efficacy of @entity6 treatment for @entity2 in both @entity0 and @entity0 with either @entity5 . MATERIAL AND METHODS: Randomized controlled trials with @entity6 treatment for @entity2 were retrieved from PubMed, EMBASE and clinicaltrials.gov. The risk ratio with 95% confidence interval (RR, 95% CI) was calculated to evaluate the effect of @entity6 treatment on incidence of @entity5 . Data on changes in @entity1 ( @entity1 ) following @entity6 ( @entity7 ) treatment was also extracted. STATA software was used for all the statistical analyses. RESULTS: Significant reduction in the incidence of both vertebral and nonvertebral @entity5 was observed following @entity7 treatment, as seen from the values for RR with 95% CI (RR 0.24 and 95% CI 0.15 to 0.40 for @entity5 ; RR 0.76 and 95% CI 0.67 to 0.86 for @entity5 ). @entity1 was also seen to be increased after @entity7 treatment. CONCLUSION: Ourmeta-analysis showed that @entity6 was effective in reducing the incidence of @entity5 as well as @entity5 , including @entity4 . Significant increase in @entity1 ( @entity1 ) was also observed in @entity0 administered @entity7 as compared to placebo.

title: Efficacy of @entity6 in treatment of @entity2 in XXXX and @entity0 -a meta-analysis.

answer: @entity0


abstract: BACKGROUND: @entity2 is a significant cause of morbidity and mortality in the elderly and an important public health issue. @entity3 are the primary treatment options for @entity2 . The oral administration of @entity3 may result in poor @entity0 compliance and thence reduced treatment efficacy. Intravenously administered @entity3 may therefore show better treatment efficacy. We have carried out a meta-analysis to evaluate the efficacy of @entity6 treatment for @entity2 in both @entity0 and @entity0 with either @entity5 . MATERIAL AND METHODS: Randomized controlled trials with @entity6 treatment for @entity2 were retrieved from PubMed, EMBASE and clinicaltrials.gov. The risk ratio with 95% confidence interval (RR, 95% CI) was calculated to evaluate the effect of @entity6 treatment on incidence of @entity5 . Data on changes in @entity1 ( @entity1 ) following @entity6 ( @entity7 ) treatment was also extracted. STATA software was used for all the statistical analyses. RESULTS: Significant reduction in the incidence of both vertebral and nonvertebral @entity5 was observed following @entity7 treatment, as seen from the values for RR with 95% CI (RR 0.24 and 95% CI 0.15 to 0.40 for @entity5 ; RR 0.76 and 95% CI 0.67 to 0.86 for @entity5 ). @entity1 was also seen to be increased after @entity7 treatment. CONCLUSION: Ourmeta-analysis showed that @entity6 was effective in reducing the incidence of @entity5 as well as @entity5 , including @entity4 . Significant increase in @entity1 ( @entity1 ) was also observed in @entity0 administered @entity7 as compared to placebo.

title: Efficacy of @entity6 in treatment of @entity2 in @entity0 and XXXX -a meta-analysis.

answer: @entity0


abstract: OBJECTIVE: It is widely reported that @entity3 (+)Gr1+ myeloid-derived suppressor cells can cause allograft tolerance in @entity1 and @entity0 , however, little is known on the therapy role in chronic transplantation rejection. In this paper, their role in corneal transplantation was studied for the first time. METHOD: Inhibitory @entity3 (+) cells were obtained by @entity1 @entity2 -induced septic model. Phenotype, endocytosis, antigen presenting ability, and T cell suppression assays were performed by flow cytometry analysis. The suppressive ability in vivo was analyzed by targeting allogeneic corneal transplantation. RESULTS: @entity2 was intraperitoneally injected into C57BL/6 @entity1 , the percentage of @entity3 (+) Gr1+ cells was increased in @entity1 spleen, blood, and bone marrow, respectively. Compared with control @entity1 , @entity5 , @entity4 , and MHC-11 expression were higher in @entity2 treated @entity1 . @entity3 (+) Gr1+ cells could inhibit allogenic corneal reaction in vivo after adoptive transfer, in consistent with an observation of inhibition effect on the antigen presenting cells (APCs) and CD4+ T cells proliferation in vitro. CONCLUSION: @entity3 (+) cells induced by @entity2 could function as inhibitory APCs, suppress CD4+ T cells proliferation and improve corneal allograft survival. Predictly, its application for cells transfer therapy in clinic in the further.

title: Protection by XXXX -induced inhibitory @entity3 (+) cells on corneal allograft.

answer: @entity2


abstract: OBJECTIVE: It is widely reported that @entity3 (+)Gr1+ myeloid-derived suppressor cells can cause allograft tolerance in @entity1 and @entity0 , however, little is known on the therapy role in chronic transplantation rejection. In this paper, their role in corneal transplantation was studied for the first time. METHOD: Inhibitory @entity3 (+) cells were obtained by @entity1 @entity2 -induced septic model. Phenotype, endocytosis, antigen presenting ability, and T cell suppression assays were performed by flow cytometry analysis. The suppressive ability in vivo was analyzed by targeting allogeneic corneal transplantation. RESULTS: @entity2 was intraperitoneally injected into C57BL/6 @entity1 , the percentage of @entity3 (+) Gr1+ cells was increased in @entity1 spleen, blood, and bone marrow, respectively. Compared with control @entity1 , @entity5 , @entity4 , and MHC-11 expression were higher in @entity2 treated @entity1 . @entity3 (+) Gr1+ cells could inhibit allogenic corneal reaction in vivo after adoptive transfer, in consistent with an observation of inhibition effect on the antigen presenting cells (APCs) and CD4+ T cells proliferation in vitro. CONCLUSION: @entity3 (+) cells induced by @entity2 could function as inhibitory APCs, suppress CD4+ T cells proliferation and improve corneal allograft survival. Predictly, its application for cells transfer therapy in clinic in the further.

title: Protection by @entity2 -induced inhibitory XXXX (+) cells on corneal allograft.

answer: @entity3


abstract: Approximately 10% of @entity1 ( @entity1 ) cases develop @entity6 ( @entity6 ). Many @entity1 @entity0 with @entity6 have relatively limited disease, requiring curative rather than palliative treatment. Besides chemotherapy, radiotherapy is important for treating @entity1 with @entity6 . We retrospectively evaluated the influence of radiotherapy dose on the prognosis of 57 @entity0 with @entity1 with @entity6 treated with concurrent chemoradiotherapy. The mean biological equivalent radiation dose was 71.5 Gy. We administered @entity4 / @entity2 as sequential and concurrent chemotherapy. All @entity0 received at least one cycle of concurrent chemotherapy. All @entity0 had partial or complete response; @entity6 -associated symptoms were reduced in 87.7% (50/57) of @entity0 within 3-10 days after treatment. Radiation dose did not affect 2-year local control (74.2% vs. 80.8%). @entity0 who received high-dose radiation had a lower 2-year overall survival rate than those who received low-dose radiation (11.6 vs. 33%; P = 0.024). The high dose group median survival was 15.0 months (95% confidence interval [CI]: 11.2-19.0) compared with 18.7 months (95% CI: 13.9-23.6) in the low dose group. Grade 3/4 @entity3 occurred in 22/26 high dose @entity0 (84.6%) and 21/31 low dose @entity0 (67.7%). In the high dose group, 30.8% of @entity0 had grade 3/4 @entity5 compared with 19.4% of low dose @entity0 . Only 29.0% of low dose @entity0 received < 4 cycles of chemotherapy in the first 12 weeks after treatment began compared with 46.2% of high dose @entity0 . Concurrent chemoradiotherapy is a tolerable modality for treating stage IIIA/IIIB @entity1 with @entity6 . Moderate-dose radiotherapy is preferable.

title: Radiation dose is associated with prognosis of XXXX with @entity6 .

answer: @entity1


abstract: Approximately 10% of @entity1 ( @entity1 ) cases develop @entity6 ( @entity6 ). Many @entity1 @entity0 with @entity6 have relatively limited disease, requiring curative rather than palliative treatment. Besides chemotherapy, radiotherapy is important for treating @entity1 with @entity6 . We retrospectively evaluated the influence of radiotherapy dose on the prognosis of 57 @entity0 with @entity1 with @entity6 treated with concurrent chemoradiotherapy. The mean biological equivalent radiation dose was 71.5 Gy. We administered @entity4 / @entity2 as sequential and concurrent chemotherapy. All @entity0 received at least one cycle of concurrent chemotherapy. All @entity0 had partial or complete response; @entity6 -associated symptoms were reduced in 87.7% (50/57) of @entity0 within 3-10 days after treatment. Radiation dose did not affect 2-year local control (74.2% vs. 80.8%). @entity0 who received high-dose radiation had a lower 2-year overall survival rate than those who received low-dose radiation (11.6 vs. 33%; P = 0.024). The high dose group median survival was 15.0 months (95% confidence interval [CI]: 11.2-19.0) compared with 18.7 months (95% CI: 13.9-23.6) in the low dose group. Grade 3/4 @entity3 occurred in 22/26 high dose @entity0 (84.6%) and 21/31 low dose @entity0 (67.7%). In the high dose group, 30.8% of @entity0 had grade 3/4 @entity5 compared with 19.4% of low dose @entity0 . Only 29.0% of low dose @entity0 received < 4 cycles of chemotherapy in the first 12 weeks after treatment began compared with 46.2% of high dose @entity0 . Concurrent chemoradiotherapy is a tolerable modality for treating stage IIIA/IIIB @entity1 with @entity6 . Moderate-dose radiotherapy is preferable.

title: Radiation dose is associated with prognosis of @entity1 with XXXX .

answer: @entity6


abstract: OBJECTIVE: To investigate the clinical efficacy of gastric bypass surgery in @entity2 @entity0 with @entity3 2 @entity1 . METHODS: Clinical data of 58 @entity2 @entity0 with @entity3 2 @entity1 (body mass index range from 22.1-25.8 kg/m(2)) were collected one year after gastric bypass surgery. Collected parameters included fasting plasma @entity4 , 2-hour postprandial blood @entity4 , glycosylated hemoglobin, fasting plasma glucagon-like peptide-1 and 2-hour postprandial plasma glucagon-like peptide-1. The insulin resistance index (HOMA-IR = fasting plasma @entity4 * fasting serum insulin/22.5) and the body mass index were calculated. RESULTS: Of the 58 @entity0 , 48 had stopped taking all hypoglycemic drug treatments and had achieved complete remission (82.8%). Seven @entity0 were unable to completely withdraw from hypoglycemic agents, although their intake of drugs was reduced at least 50% compared to pre-surgical values (12.0%). Three of the cases showed no significant change in blood @entity4 after surgery (5.2%). In addition, values for fasting plasma @entity4 , 2-hour postprandial blood @entity4 , glycosylated hemoglobin and HOMA-IR significantly decreased after surgery. Values for fasting plasma glucagon-like peptide-1 and 2-hour postprandial plasma glucagon-like peptide-1 significantly increased after surgery, and the body mass index at the sixth post-operative month were significantly lower than pre-operative. CONCLUSION: For @entity2 @entity0 with @entity3 2 @entity1 , gastric bypass surgery has a significant clinical effect. Potential mechanisms include improvements in insulin resistance and/or increased endogenous intestinal glucagon-like peptide-1 secretion leading to improved insulin secretion.

title: Gastric bypass surgery in XXXX @entity0 with @entity1 : a 1-year follow-up of 58 cases in Chinese.

answer: @entity2


abstract: OBJECTIVE: To investigate the clinical efficacy of gastric bypass surgery in @entity2 @entity0 with @entity3 2 @entity1 . METHODS: Clinical data of 58 @entity2 @entity0 with @entity3 2 @entity1 (body mass index range from 22.1-25.8 kg/m(2)) were collected one year after gastric bypass surgery. Collected parameters included fasting plasma @entity4 , 2-hour postprandial blood @entity4 , glycosylated hemoglobin, fasting plasma glucagon-like peptide-1 and 2-hour postprandial plasma glucagon-like peptide-1. The insulin resistance index (HOMA-IR = fasting plasma @entity4 * fasting serum insulin/22.5) and the body mass index were calculated. RESULTS: Of the 58 @entity0 , 48 had stopped taking all hypoglycemic drug treatments and had achieved complete remission (82.8%). Seven @entity0 were unable to completely withdraw from hypoglycemic agents, although their intake of drugs was reduced at least 50% compared to pre-surgical values (12.0%). Three of the cases showed no significant change in blood @entity4 after surgery (5.2%). In addition, values for fasting plasma @entity4 , 2-hour postprandial blood @entity4 , glycosylated hemoglobin and HOMA-IR significantly decreased after surgery. Values for fasting plasma glucagon-like peptide-1 and 2-hour postprandial plasma glucagon-like peptide-1 significantly increased after surgery, and the body mass index at the sixth post-operative month were significantly lower than pre-operative. CONCLUSION: For @entity2 @entity0 with @entity3 2 @entity1 , gastric bypass surgery has a significant clinical effect. Potential mechanisms include improvements in insulin resistance and/or increased endogenous intestinal glucagon-like peptide-1 secretion leading to improved insulin secretion.

title: Gastric bypass surgery in @entity2 @entity0 with XXXX : a 1-year follow-up of 58 cases in Chinese.

answer: @entity1


abstract: OBJECTIVE: To investigate the clinical efficacy of gastric bypass surgery in @entity2 @entity0 with @entity3 2 @entity1 . METHODS: Clinical data of 58 @entity2 @entity0 with @entity3 2 @entity1 (body mass index range from 22.1-25.8 kg/m(2)) were collected one year after gastric bypass surgery. Collected parameters included fasting plasma @entity4 , 2-hour postprandial blood @entity4 , glycosylated hemoglobin, fasting plasma glucagon-like peptide-1 and 2-hour postprandial plasma glucagon-like peptide-1. The insulin resistance index (HOMA-IR = fasting plasma @entity4 * fasting serum insulin/22.5) and the body mass index were calculated. RESULTS: Of the 58 @entity0 , 48 had stopped taking all hypoglycemic drug treatments and had achieved complete remission (82.8%). Seven @entity0 were unable to completely withdraw from hypoglycemic agents, although their intake of drugs was reduced at least 50% compared to pre-surgical values (12.0%). Three of the cases showed no significant change in blood @entity4 after surgery (5.2%). In addition, values for fasting plasma @entity4 , 2-hour postprandial blood @entity4 , glycosylated hemoglobin and HOMA-IR significantly decreased after surgery. Values for fasting plasma glucagon-like peptide-1 and 2-hour postprandial plasma glucagon-like peptide-1 significantly increased after surgery, and the body mass index at the sixth post-operative month were significantly lower than pre-operative. CONCLUSION: For @entity2 @entity0 with @entity3 2 @entity1 , gastric bypass surgery has a significant clinical effect. Potential mechanisms include improvements in insulin resistance and/or increased endogenous intestinal glucagon-like peptide-1 secretion leading to improved insulin secretion.

title: Gastric bypass surgery in @entity2 XXXX with @entity1 : a 1-year follow-up of 58 cases in Chinese.

answer: @entity0


abstract: @entity3 ( @entity3 ) are defined as @entity2 developing in relation to health services at inpatient treatment facilities in general. Although health services improve, @entity3 continue to be seen both in underdeveloped and developed countries. @entity3 result in a range of negative externalities. Negative externalities include factors such as an increase in morbidity and mortality, extension of the hospitalization duration, impaired quality of life, loss of working power and performance. @entity3 pose a big burden regarding population and community health care. This study aims to calculate the financial burden of @entity3 by evaluating it within the scope of negative externality. The communal costs of @entity3 @entity0 were calculated by using a genuine approach with reference to samples obtained from the Duzce University Research and Application Hospital. This approach includes 4 stages and the results of each stage is sorted according to the data of 2013 as follows: (i) @entity3 expenditure undertaken by the Social Security Institution is 5,832,167 TL, (ii) the monetary value of the work power loss of the @entity3 @entity0 who are at a working age is 126,154 TL, (iii) the relative cost of @entity3 @entity0 compared to a group of normal @entity0 is 21,507 TL and (iv) @entity3 @entity0 ' communal cost is 6,013,101 TL. Based on the received results, the annual communal cost of the estimated @entity3 @entity0 in @entity1 is predicted to be 3,640,442,057 TL. In addition to these findings, @entity3 @entity0 experience 14 times longer in- @entity0 stay at the hospitals as compared to normal @entity0 , and their treatment expenditures are 23 times higher than the normal @entity0 . In the conclusion part of the study, regarding the preventability (internalization) of @entity3 , which was evaluated as part of negative externality, alternative applicable political suggestions are presented for the use of policymakers.

title: An implementation on the social cost of hospital acquired XXXX .

answer: @entity2


abstract: The aim of the study is to investigate the feasibility of pre-operative autologous blood donation (PABD) self-transfusion on the postpartum recovery and the endocrine in lying-in @entity0 . The PABD is carried out on 70 pregnant @entity0 who have high risk of postpartum @entity2 . Those 70 subjects were divided into three groups: 33 cases of PABD self-transfusion during the Cesarean section; 16 cases of PABD self-transfusion as a physiological means and 21 cases without transfusion. Serum levels of @entity1 (E2), @entity3 (P), @entity4 ( @entity4 ) hormone are evaluated 48 hours before and after labor; Postpartum colostrum timing, milk yield, short term and long term uterine contraction are observed among the cases. No significance were observed among the three groups on E2, P, @entity4 hormone 48 hours before and after labor. The @entity4 concentration in PABD self-transfusion group is higher than that in the group without self-transfusion 48 hours after labor. Using different PABD self-transfusion strategies, significant difference of the initial milk yield time were observed in the three groups (F=6.035 P=0.004), but the milk yield is no significant different on second day and third day. The self-transfusion of PABD has little influence on uterine contraction. For the @entity0 who underwent Cesarean Section, the PABD self-transfusion is conducive to the increase of @entity4 level. The PABD self-transfusion advances the commencement time of milk yield, while with little effect on neither milk yield volume nor uterine contraction.

title: The effect of pre-operative autologous blood donation self-transfusion on hormone and postpartum convalescence in Lying-in XXXX .

answer: @entity0


abstract: Chronic infusion of @entity4 (PGI2) via a Broviac central venous line (CVL) is attended by risk of CVL-related complications, but we know of only one report regarding CVL-associated @entity2 ( @entity2 ) with PGI2 in @entity0 and none regarding other complications. We conducted a retrospective cohort study involving pediatric @entity0 with @entity1 treated with chronic intravenous infusion of PGI2 at Boston @entity0 's Hospital and determined the rate (per 1,000 line-days) of various CVL-related complications. We also determined how often complications necessitated line replacement and hospitalization, time to replacement of CVLs, and interpatient variability in the incidence of complications. From 1999 until 2014, 26 @entity0 meeting follow-up criteria had PGI2 infusion, representing 43,855 line-days; mean follow-up was 56 months (range, 1.4-161 months). The CVL complication rates (per 1,000 line-days) were as follows: CVL- @entity2 , 0.25; superficial line infection, 0.48; impaired integrity, 0.59; occlusion, 0.09; and malposition, 0.32. The total complication rate was 1.73 cases per 1,000 line-days. All CVL- @entity2 and malposition cases were treated with CVL removal and replacement. Of CVLs with impaired integrity, 23 could be repaired and 3 required replacement. Six of 21 superficial @entity3 required replacement of the CVL. Three of 4 occluded CVLs were replaced. CVL complications occasioned 65 hospitalizations. There was marked interpatient variability in the rate of complications, much but not all of which appeared to be related to duration of CVL placement. We conclude that non- @entity2 complications are very significant and that efforts to teach and emphasize other aspects of line care are therefore very important.

title: Central venous line complications with chronic ambulatory infusion of @entity4 analogues in pediatric @entity0 with XXXX .

answer: @entity1


abstract: Chronic infusion of @entity4 (PGI2) via a Broviac central venous line (CVL) is attended by risk of CVL-related complications, but we know of only one report regarding CVL-associated @entity2 ( @entity2 ) with PGI2 in @entity0 and none regarding other complications. We conducted a retrospective cohort study involving pediatric @entity0 with @entity1 treated with chronic intravenous infusion of PGI2 at Boston @entity0 's Hospital and determined the rate (per 1,000 line-days) of various CVL-related complications. We also determined how often complications necessitated line replacement and hospitalization, time to replacement of CVLs, and interpatient variability in the incidence of complications. From 1999 until 2014, 26 @entity0 meeting follow-up criteria had PGI2 infusion, representing 43,855 line-days; mean follow-up was 56 months (range, 1.4-161 months). The CVL complication rates (per 1,000 line-days) were as follows: CVL- @entity2 , 0.25; superficial line infection, 0.48; impaired integrity, 0.59; occlusion, 0.09; and malposition, 0.32. The total complication rate was 1.73 cases per 1,000 line-days. All CVL- @entity2 and malposition cases were treated with CVL removal and replacement. Of CVLs with impaired integrity, 23 could be repaired and 3 required replacement. Six of 21 superficial @entity3 required replacement of the CVL. Three of 4 occluded CVLs were replaced. CVL complications occasioned 65 hospitalizations. There was marked interpatient variability in the rate of complications, much but not all of which appeared to be related to duration of CVL placement. We conclude that non- @entity2 complications are very significant and that efforts to teach and emphasize other aspects of line care are therefore very important.

title: Central venous line complications with chronic ambulatory infusion of XXXX analogues in pediatric @entity0 with @entity1 .

answer: @entity4


abstract: Chronic infusion of @entity4 (PGI2) via a Broviac central venous line (CVL) is attended by risk of CVL-related complications, but we know of only one report regarding CVL-associated @entity2 ( @entity2 ) with PGI2 in @entity0 and none regarding other complications. We conducted a retrospective cohort study involving pediatric @entity0 with @entity1 treated with chronic intravenous infusion of PGI2 at Boston @entity0 's Hospital and determined the rate (per 1,000 line-days) of various CVL-related complications. We also determined how often complications necessitated line replacement and hospitalization, time to replacement of CVLs, and interpatient variability in the incidence of complications. From 1999 until 2014, 26 @entity0 meeting follow-up criteria had PGI2 infusion, representing 43,855 line-days; mean follow-up was 56 months (range, 1.4-161 months). The CVL complication rates (per 1,000 line-days) were as follows: CVL- @entity2 , 0.25; superficial line infection, 0.48; impaired integrity, 0.59; occlusion, 0.09; and malposition, 0.32. The total complication rate was 1.73 cases per 1,000 line-days. All CVL- @entity2 and malposition cases were treated with CVL removal and replacement. Of CVLs with impaired integrity, 23 could be repaired and 3 required replacement. Six of 21 superficial @entity3 required replacement of the CVL. Three of 4 occluded CVLs were replaced. CVL complications occasioned 65 hospitalizations. There was marked interpatient variability in the rate of complications, much but not all of which appeared to be related to duration of CVL placement. We conclude that non- @entity2 complications are very significant and that efforts to teach and emphasize other aspects of line care are therefore very important.

title: Central venous line complications with chronic ambulatory infusion of @entity4 analogues in pediatric XXXX with @entity1 .

answer: @entity0


abstract: The challenge hypothesis has been enormously successful in predicting interspecific @entity1 profiles for vertebrate males. Nevertheless, in the absence of another theoretical framework, many researchers 'retrofit' the challenge hypothesis, so that its predictions also apply to intraspecific @entity1 comparisons. We use a wild primate, geladas (Theropithecus gelada), to illustrate several considerations for @entity1 research surrounding male contests that do not necessarily fit within the challenge hypothesis framework. Gelada society comprises harem-holding males (that can mate with females) and bachelor males (that cannot mate with females until they take over a harem). Using 6 years of data from known males, we measured @entity2 (i.e. faecal @entity0 (fT) metabolites) both seasonally and across specific male contests. Seasonal @entity1 variation exhibited a very different pattern than variation resulting from male contests. Although harem-holding males had higher @entity0 levels than bachelors across the year, bachelors had higher @entity0 during the annual 'takeover season'. Thus, harem-holding males did not 'rise to the challenge' exactly when needed most. Yet, @entity1 profiles across male contests indicated that both sets of males exhibit the expected fT rise in response to challenges. Results from male geladas also support the idea that the context before (e.g. male condition) and after (e.g. contest outcome) a contest are critical variables for predicting hormones and behaviour.

title: Harem-holding males do not rise to the challenge: XXXX respond to social but not to seasonal challenges in wild geladas.

answer: @entity2


abstract: Objective. To study the reproductive outcomes of @entity3 ( @entity3 ), a surgical technique designed to increase the working surface area of the fimbriated end of the fallopian tube. We postulated that an improvement in fimbrial function through @entity3 will improve reproductive outcomes. Design. Retrospective cohort study. Setting. Academic tertiary-care medical center. @entity0 . @entity0 with minimal @entity1 or @entity2 , who underwent @entity3 during diagnostic laparoscopy (n = 50) or diagnostic laparoscopy alone (n = 87). Intervention. @entity3 involved gentle, circumferential dilatation of the fimbria and lysis of fimbrial adhesions bridging the fimbrial folds. Main Outcome Measures. The primary outcome was pregnancy rate and the secondary outcome was time to pregnancy. Results. The pregnancy rate for the @entity3 group was 40.0%, compared to 28.7% for the control group. The average time to pregnancy for the @entity3 group was 13 weeks, compared to 18 weeks for the control group. The pregnancy rate in the @entity3 group was significantly higher for @entity0  <=35   ys (51.5% versus 28.8%), but not for those >35   ys (17.6% versus 28.6%). Conclusion. @entity3 was associated with a significant increase in pregnancy rate for @entity0  <=35   ys.

title: Clinical Effectiveness of Modified Laparoscopic Fimbrioplasty for the Treatment of Minimal XXXX .

answer: @entity2


abstract: Background. The cerebellum as initial site of distant @entity1 from differentiated @entity2 (DTC) including papillary (PTC) and @entity2 ( @entity2 ) is rare manifestation. Case Presentations. Herein, we present three cases of cerebellar @entity1 (CBM) of PTC. Mean age of @entity0 was 67 years (range: 64-72), and mean duration between initial diagnosis and CBM was 49.6 months (range: 37-61). Frequent location was left cerebellar hemisphere and was associated with @entity3 . All @entity0 underwent suboccipital craniectomy, and in two @entity0 postoperative intensity modulated radiation therapy (IMRT) was given to deliver 5000   cGy in 25 fractions to residual lesions. @entity0 without postoperative IMRT had cerebellar recurrence along with lung and bone @entity1 after 38 months. However, two @entity0 were found alive and free of disease at the time of last follow-up. Conclusion. CBM from PTC is a rare clinical entity and is often associated with @entity3 . Histopathological diagnosis is important to initiate effective treatment, which relies on multidisciplinary approach to prolong the disease-free and overall survival rates.

title: Cerebellum as Initial Site of Distant XXXX from Papillary Carcinoma of Thyroid: Review of Three Cases.

answer: @entity1


abstract: BACKGROUND: Falls and related @entity1 are common health problems in the elderly. @entity4 , brain and internal organ @entity1 and @entity5 are the common consequences of the falls, which result in @entity7 , decreased self-efficacy, fear of falling, @entity6 , restricted daily activities, hospitalization and admission to the nursing home and impose costs on the individual and the society. OBJECTIVES: The purpose of this study was to determine the types of fall-related @entity1 and the related risk factors in the elderly population of Qom province, Iran. @entity0 AND METHODS: This retrospective study was performed on 424 elderly @entity0 (65 years and over) referred to Shahid Beheshti Hospital, Qom, Iran, due to falls between 2010 and 2012. The ICD-10 codes of external causes of injury from w00 to w19 related to falls were selected from the health information system of the hospital and demographic variables of the @entity0 and external causes of falls were extracted after accessing the files of the @entity0 . Data were analyzed using SPSS version 18 (SPSS Inc., USA). The duration of hospital stay and its relationship with underlying variables were investigated using t test and ANOVA. The level of significance was considered P < 0.05. RESULTS: Among 424 elderly @entity0 , 180 cases (42.45%) were male and the mean age of the @entity0 was 78.65    7.70 years. Fall on the same level from slipping, tripping, and stumbling was the most common external cause with 291 victims (68.60%), and @entity3 in 121 @entity0 (29.00%), intertrochanteric fracture in 112 @entity0 (26.90%), and @entity2 in 51 @entity0 (12.20%) were the most common causes of hospital stay. The mean hospital stay was 7.33    3.63 days. CONCLUSIONS: @entity4 and @entity2 were the most common causes of hospitalization, which resulted in the longest hospital stay and highest hospitalization costs in the elderly.

title: XXXX in Community-Dwelling Older Adults in Qom Province, Iran, 2010-2012.

answer: @entity1


abstract: UNASSIGNED: Although the expression of T-cell antigens and proteins associated with @entity0 -infiltrating T-lymphocytes (TILs), regulatory T cells (T-regs), and B-cell development have been evaluated in classical @entity2 (cHL), few studies correlate these proteins' expression patterns with clinical outcome. The purpose of this study was to evaluate proteins expressed in the Reed-Sternberg cells (RSCs) and TILs of cHLs at initial diagnosis to determine their prognostic significance. The expression of 12 proteins in RSCs and TILs from 88 diagnostic cHL biopsies was quantitated and correlated to @entity3 ( @entity3 ) and progression-free survival (PFS). @entity5 , CD3, @entity1 , @entity8 , @entity7 , @entity4 , @entity11 , @entity12 , @entity13 , and @entity10 expression in RSCs did not correlate with @entity3 or PFS, nor did programmed death 1 ( @entity11 ) expression in TILs. High numbers of @entity12 -positive TILs (>= 50%) correlated with @entity3 (P=0.027), but not PFS (P=0.993) in univariate analysis. Expression of @entity5 , CD3, @entity1 , @entity8 , and/or @entity12 (6%) in RSCs was associated with lymphocyte-rich/mixed-cellularity subtype (P=0.032). High @entity6 ( @entity6 ; P=0.036), and high stage (P=0.046) were independent predictors of worse PFS in univariate analysis. Low @entity6 (P=0.003) and nodular sclerosing subtype (P=0.022) were associated with better @entity3 in univariate analysis. Only the @entity6 predicted @entity3 in multivariate (P=0.009) analysis. High @entity12 + TILs correlated with worse clinical outcomes for cHLs, as did @entity9 -RSCs (P=0.024), although only 2/74 cases were shown to be negative for this marker, suggesting that the @entity0 microenvironment and a transcription factor crucial for B-cell development are critical biological determinants of the disease course.

title: Expression of @entity12 and @entity9 in XXXX at Initial Diagnosis May Predict Clinical Outcome.

answer: @entity2


abstract: UNASSIGNED: Although the expression of T-cell antigens and proteins associated with @entity0 -infiltrating T-lymphocytes (TILs), regulatory T cells (T-regs), and B-cell development have been evaluated in classical @entity2 (cHL), few studies correlate these proteins' expression patterns with clinical outcome. The purpose of this study was to evaluate proteins expressed in the Reed-Sternberg cells (RSCs) and TILs of cHLs at initial diagnosis to determine their prognostic significance. The expression of 12 proteins in RSCs and TILs from 88 diagnostic cHL biopsies was quantitated and correlated to @entity3 ( @entity3 ) and progression-free survival (PFS). @entity5 , CD3, @entity1 , @entity8 , @entity7 , @entity4 , @entity11 , @entity12 , @entity13 , and @entity10 expression in RSCs did not correlate with @entity3 or PFS, nor did programmed death 1 ( @entity11 ) expression in TILs. High numbers of @entity12 -positive TILs (>= 50%) correlated with @entity3 (P=0.027), but not PFS (P=0.993) in univariate analysis. Expression of @entity5 , CD3, @entity1 , @entity8 , and/or @entity12 (6%) in RSCs was associated with lymphocyte-rich/mixed-cellularity subtype (P=0.032). High @entity6 ( @entity6 ; P=0.036), and high stage (P=0.046) were independent predictors of worse PFS in univariate analysis. Low @entity6 (P=0.003) and nodular sclerosing subtype (P=0.022) were associated with better @entity3 in univariate analysis. Only the @entity6 predicted @entity3 in multivariate (P=0.009) analysis. High @entity12 + TILs correlated with worse clinical outcomes for cHLs, as did @entity9 -RSCs (P=0.024), although only 2/74 cases were shown to be negative for this marker, suggesting that the @entity0 microenvironment and a transcription factor crucial for B-cell development are critical biological determinants of the disease course.

title: Expression of XXXX and @entity9 in @entity2 at Initial Diagnosis May Predict Clinical Outcome.

answer: @entity12


abstract: UNASSIGNED: Although the expression of T-cell antigens and proteins associated with @entity0 -infiltrating T-lymphocytes (TILs), regulatory T cells (T-regs), and B-cell development have been evaluated in classical @entity2 (cHL), few studies correlate these proteins' expression patterns with clinical outcome. The purpose of this study was to evaluate proteins expressed in the Reed-Sternberg cells (RSCs) and TILs of cHLs at initial diagnosis to determine their prognostic significance. The expression of 12 proteins in RSCs and TILs from 88 diagnostic cHL biopsies was quantitated and correlated to @entity3 ( @entity3 ) and progression-free survival (PFS). @entity5 , CD3, @entity1 , @entity8 , @entity7 , @entity4 , @entity11 , @entity12 , @entity13 , and @entity10 expression in RSCs did not correlate with @entity3 or PFS, nor did programmed death 1 ( @entity11 ) expression in TILs. High numbers of @entity12 -positive TILs (>= 50%) correlated with @entity3 (P=0.027), but not PFS (P=0.993) in univariate analysis. Expression of @entity5 , CD3, @entity1 , @entity8 , and/or @entity12 (6%) in RSCs was associated with lymphocyte-rich/mixed-cellularity subtype (P=0.032). High @entity6 ( @entity6 ; P=0.036), and high stage (P=0.046) were independent predictors of worse PFS in univariate analysis. Low @entity6 (P=0.003) and nodular sclerosing subtype (P=0.022) were associated with better @entity3 in univariate analysis. Only the @entity6 predicted @entity3 in multivariate (P=0.009) analysis. High @entity12 + TILs correlated with worse clinical outcomes for cHLs, as did @entity9 -RSCs (P=0.024), although only 2/74 cases were shown to be negative for this marker, suggesting that the @entity0 microenvironment and a transcription factor crucial for B-cell development are critical biological determinants of the disease course.

title: Expression of @entity12 and XXXX in @entity2 at Initial Diagnosis May Predict Clinical Outcome.

answer: @entity9


abstract: OBJECTIVE: When comparing performance across hospitals it is essential to consider the noise caused by low hospital case volume and to perform adequate case-mix adjustment. We aimed to quantify the role of noise and case-mix adjustment on standardized postoperative mortality and @entity2 ( @entity2 ) rates. METHODS: We studied 13  120 @entity0 who underwent @entity1 resection in 85 Dutch hospitals. We addressed differences between hospitals in postoperative mortality and @entity2 , using fixed (ignoring noise) and random effects (incorporating noise) logistic regression models with general and additional, disease specific, case-mix adjustment. RESULTS: Adding disease specific variables improved the performance of the case-mix adjustment models for postoperative mortality (c-statistic increased from 0.77 to 0.81). The overall variation in standardized mortality ratios was similar, but some individual hospitals changed considerably. For the standardized @entity2 rates the performance of the adjustment models was poor (c-statistic 0.59 and 0.60) and overall variation was small. Most of the observed variation between hospitals was actually noise. CONCLUSION: Noise had a larger effect on hospital performance than extended case-mix adjustment, although some individual hospital outcome rates were affected by more detailed case-mix adjustment. To compare outcomes between hospitals it is crucial to consider noise due to low hospital case volume with a random effects model.

title: Comparing XXXX outcomes: The impact of low hospital case volume and case-mix adjustment.

answer: @entity1


abstract: AIM: The purpose of this study was to determine the root form and canal configuration in maxillary first premolars. MATERIALS AND METHODS: A total of 250 extracted @entity0 adult maxillary first @entity3 from North Indian population were collected. Access cavities were prepared and the coronal pulp tissue was extirpated. The samples were stored in 5% @entity5 solution for 5 days. They were then rinsed, dried, and dehydrated using increasing concentrations of @entity2 (70, 80, and 95%) successively for 1 day. Teeth were rendered transparent by immersing in @entity4 . India ink was then injected. The root canal morphology was examined under stereomicroscope. RESULT: 53.6% were single rooted followed by fused root form followed by two root form. 0.4% had three rooted maxillary first premolar. Variable root canal configurations were also found. @entity1 was most prevalent (33.2%). Two teeth showed an additional configuration. Lateral canals were present in 34.8% of the samples and intercanal communications in 16%. CONCLUSION: Within the limitations of this study, it was concluded that in North Indian population, there was an increased propensity for types IV, I, II, and III canal morphologies in maxillary first premolars. Single root form was most common.

title: Root and canal morphology of maxillary first XXXX in north Indian population using clearing technique: An in vitro study.

answer: @entity3


abstract: In a multicenter study we have evaluated the effect of immunotherapy with pooled buffy coats on @entity0 with @entity2 . 21 @entity0 were selected under the same criteria with respect to clinical, immunological and blood banking conditions. All @entity0 have had at least two miscarriages with the same partner and no living @entity0 (except one case). Additionally, all well-known reasons for abortions were excluded. The couples were tested for @entity3 antigens as well as for the presence of HLA-antibodies. The couples with recurrent @entity1 suggested a significantly higher compatibility in two or more antigens in comparison to the control couples with @entity0 and without any abortion. Before treatment there was no case with cytotoxic HLA antibodies. 10 @entity0 received each two pooled buffy coats intravenously before pregnancy at time intervals of 3 weeks. 15 @entity0 were treated in early pregnancy until the 28th week of gestation at the same application intervals. In the meantime 10 of 15 @entity0 have delivered at term a healthy and mature @entity0 with normal weight. Four of 15 are still pregnant in the third trimester of pregnancy. In one case the pregnancy resulted in an abortion. The buffy coat transfusions were well tolerated and led in no case to the formation of antierythrocytic antibodies. 12 of 21 @entity0 treated developed HLA antibodies at various time intervals during immunotherapy, mainly with a low titre. In 7 of 10 cases the antibodies occurred in the treatment period before pregnancy, in 5 of 15 cases during pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Clinical and immunologic results of immunotherapy with pooled buffy coat transfusions in females with XXXX ].

answer: @entity2


abstract: PURPOSE: To evaluate the long-term efficacy and safety of slow-release @entity2 intravitreal implant (DEX implant) in @entity0 with refractory @entity4 ( @entity4 ) secondary to @entity6 ( @entity6 ) in Taiwan. METHODS: We conducted a retrospective chart review of @entity0 with a diagnosis of @entity4 secondary to @entity6 who received the DEX implant at Kaohsiung Veterans General Hospital from October 2010 to February 2014. RESULTS: A total of 28 @entity0 with an average age of 60.7  11.1 years were examined. Of these @entity0 , 17 were diagnosed with branch @entity6 (BRVO) and 11 were diagnosed with central @entity6 (CRVO). The mean maximal change in vision from the baseline after the final injection was an improvement of 1.7  2.8 lines (equivalent to 8.5 ETDRS letters; p<0.0001). The response to the first injection was similar across both BRVO and CRVO groups, but @entity0 with BRVO showed a more favorable response than those with CRVO after the second injection. The response in @entity0 who had refractory @entity4 after at least 3 previous interventions was similar to the whole group. Three @entity0 (10.7%) had @entity5 (IOP) that was well controlled by IOP-lowering medications. None of these @entity0 required laser or @entity3 surgery. Five @entity0 (17.9%) exhibited @entity1 progression during the observation period. CONCLUSION: The DEX implant is an effective and safe treatment for @entity4 , secondary to @entity6 , including refractory @entity4 .

title: Efficacy and Safety of XXXX Intravitreal Implant for Treatment of Refractory Macular Edema Secondary to @entity6 in Taiwan.

answer: @entity2


abstract: PURPOSE: To evaluate the long-term efficacy and safety of slow-release @entity2 intravitreal implant (DEX implant) in @entity0 with refractory @entity4 ( @entity4 ) secondary to @entity6 ( @entity6 ) in Taiwan. METHODS: We conducted a retrospective chart review of @entity0 with a diagnosis of @entity4 secondary to @entity6 who received the DEX implant at Kaohsiung Veterans General Hospital from October 2010 to February 2014. RESULTS: A total of 28 @entity0 with an average age of 60.7  11.1 years were examined. Of these @entity0 , 17 were diagnosed with branch @entity6 (BRVO) and 11 were diagnosed with central @entity6 (CRVO). The mean maximal change in vision from the baseline after the final injection was an improvement of 1.7  2.8 lines (equivalent to 8.5 ETDRS letters; p<0.0001). The response to the first injection was similar across both BRVO and CRVO groups, but @entity0 with BRVO showed a more favorable response than those with CRVO after the second injection. The response in @entity0 who had refractory @entity4 after at least 3 previous interventions was similar to the whole group. Three @entity0 (10.7%) had @entity5 (IOP) that was well controlled by IOP-lowering medications. None of these @entity0 required laser or @entity3 surgery. Five @entity0 (17.9%) exhibited @entity1 progression during the observation period. CONCLUSION: The DEX implant is an effective and safe treatment for @entity4 , secondary to @entity6 , including refractory @entity4 .

title: Efficacy and Safety of @entity2 Intravitreal Implant for Treatment of Refractory Macular Edema Secondary to XXXX in Taiwan.

answer: @entity6


abstract: INTRODUCTION AND HYPOTHESIS: One of the most commonly experienced postoperative complications of the @entity3 ( @entity3 ) is @entity4 ( @entity4 ). The aim of this retrospective study was to evaluate our incidence of @entity1 , our results after tape mobilisation, and whether demographic data could predict @entity4 . METHODS: A total of 715 @entity0 underwent a @entity3 procedure without concomitant operative procedures. In the case of persisting @entity4 transvaginal tape mobilisation was performed up to 3  weeks postoperatively. The vaginal incision was reopened and downward extraction with a clamp was performed. Demographic data were investigated to predict @entity1 . RESULTS: A total of 28 @entity0 (3.9  %) experienced @entity4 . Seventeen @entity0 (2.4  %) underwent transvaginal tape mobilisation an average of 11.6  days (range 2-21) after the primary @entity3 procedure. No complications were observed in connection with the mobilisation. Eleven @entity0 (1.5  %) performed clean intermittent catheterisation (CIC) for a period of more than 1  day, with an average of 14.4  days (range 3-63). After tape mobilisation 16 @entity0 (94  %) were relieved of their @entity4 and were continent. One @entity0 was somewhat incontinent after the procedure. Age, parity and previous caesarean section did not predict @entity4 . Previous @entity2 surgery might predict @entity4 . CONCLUSIONS: The incidence of @entity4 after the @entity3 procedure requiring tape mobilisation was 2.4  %. Relief of the @entity4 was obtained after tape mobilisation in all @entity0 . Tape mobilisation is a safe and effective treatment for @entity1 .

title: Incidence and treatment of @entity1 after the XXXX .

answer: @entity3


abstract: INTRODUCTION AND HYPOTHESIS: One of the most commonly experienced postoperative complications of the @entity3 ( @entity3 ) is @entity4 ( @entity4 ). The aim of this retrospective study was to evaluate our incidence of @entity1 , our results after tape mobilisation, and whether demographic data could predict @entity4 . METHODS: A total of 715 @entity0 underwent a @entity3 procedure without concomitant operative procedures. In the case of persisting @entity4 transvaginal tape mobilisation was performed up to 3  weeks postoperatively. The vaginal incision was reopened and downward extraction with a clamp was performed. Demographic data were investigated to predict @entity1 . RESULTS: A total of 28 @entity0 (3.9  %) experienced @entity4 . Seventeen @entity0 (2.4  %) underwent transvaginal tape mobilisation an average of 11.6  days (range 2-21) after the primary @entity3 procedure. No complications were observed in connection with the mobilisation. Eleven @entity0 (1.5  %) performed clean intermittent catheterisation (CIC) for a period of more than 1  day, with an average of 14.4  days (range 3-63). After tape mobilisation 16 @entity0 (94  %) were relieved of their @entity4 and were continent. One @entity0 was somewhat incontinent after the procedure. Age, parity and previous caesarean section did not predict @entity4 . Previous @entity2 surgery might predict @entity4 . CONCLUSIONS: The incidence of @entity4 after the @entity3 procedure requiring tape mobilisation was 2.4  %. Relief of the @entity4 was obtained after tape mobilisation in all @entity0 . Tape mobilisation is a safe and effective treatment for @entity1 .

title: Incidence and treatment of XXXX after the @entity3 .

answer: @entity1


abstract: UNASSIGNED: OBJECT Few studies have addressed surgical failures and complications following percutaneous @entity3 (PELD), and no previous study has investigated the risk factors that lead to surgical failure. The authors report their experience using PELD for single-level lumbar disc herniation (LDH) to provide insights into the rates of surgical failure and identify potential risk factors that lead to this complication. METHODS The authors retrospectively reviewed the medical records of 350 @entity0 who underwent PELD for single-level LDH and identified 36 @entity0 (10.3%) who underwent reoperation due to the failure of PELD. RESULTS @entity0 ' mean visual analog scale of @entity2 scores and Oswestry Disability Index scores improved significantly from 6.6    2.1 and 51.6    19.4 preoperatively to 1.9    1.4 and 28.3    12.0, respectively, at 1 month postoperatively and 1.2    1.1 and 9.3    7.8, respectively, at 1 year postoperatively. The frequencies with which @entity0 took analgesic medications significantly decreased from 74.6% preoperatively to 19.7% at 1 month postoperatively and 10.0% at 1 year postoperatively. Relatively older @entity0 (p = 0.005) and those >=  60 years old (p = 0.001) experienced larger numbers of failures compared to younger @entity0 . An analysis of potentially contributing comorbid conditions indicated that significantly more @entity0 with @entity1 were present in the PELD failure group (p = 0.017). As surgeons gained familiarity with the procedure, outcomes improved. The failure rate during the authors' early use of the PELD technique (Cases 1-70) was 17.1%; the failure rate then fell to 5.7% (p = 0.034) (Cases 141-210) before finally stabilizing at 10.0% (Cases 211-280 and Cases 281-350). CONCLUSIONS The surgical failure rate following PELD for LDH was 10.3%. Older @entity0 , elderly @entity0 (age >=  60 years), and @entity0 with @entity1 were at increased risk of surgical failure of PELD, particularly in the early years of the procedure's use.

title: Risk factors for failure of single-level percutaneous XXXX .

answer: @entity3


abstract: Bronchial responsiveness to inhaled @entity3 was measured four to six days before fibreoptic bronchoscopy in 22 @entity2 @entity0 (10 smokers) and 20 control subjects (12 smokers). The @entity2 @entity0 had a baseline FEV1 greater than 60% predicted and a PD20FEV1 (provocative dose of @entity3 causing a 20% fall in FEV1) of 0.006-3.7 mg. The 20 control subjects had normal pulmonary function and a PD20FEV1 above the maximum cumulative dose of @entity3 of 6.4 mg. Bronchoalveolar lavage of a middle lobe segment (lingula in four subjects) was performed with three sequential 60 ml aliquots of sterile saline. Cellular metabolic activity was stimulated with latex in aliquots of resuspended cells, and measured by means of @entity4 enhanced chemiluminescence to assess neutrophil activity and @entity5 enhanced chemiluminescence to assess macrophage activity. Mean absolute total cell counts were similar in the @entity2 and control groups but there were differences in differential cell counts, with a significant increase in eosinophil (p less than 0.05) and lymphocyte (p less than 0.005) counts in @entity1 . PD20FEV1 was negatively correlated with percentage neutrophil counts (p less than 0.005). Luminol enhanced chemiluminescence/1000 neutrophils was increased about twofold in @entity2 subjects (p less than 0.001), but was not correlated with PD20FEV1 Lucigenin enhanced chemiluminescence/1000 macrophages was increased nearly fourfold in @entity2 @entity0 (p less than 0.001) and showed a negative correlation with PD20FEV1 (p less than 0.01). The macrophage count was increased twofold in current smokers in both groups, but other cell numbers were not altered significantly. Smoking did not affect cellular metabolic activity in either group. This study supports the idea that an inflammatory process is present in the airways of those with @entity1 , and suggests a relation between bronchial responsiveness and both neutrophil numbers and macrophage activity.

title: Number and activity of inflammatory cells in bronchoalveolar lavage fluid in XXXX and their relation to airway responsiveness.

answer: @entity1


abstract: Pulse deficit in @entity0 with @entity2 is caused by the reduction of preload. The purpose of this study was to visualize the mechanism in view of blood flow dynamics using pulsed Doppler echocardiography. The subjects were 15 cases with @entity2 and @entity1 , and the results were as follows: 1. Simultaneous recordings of the @entity3 ( @entity3 ) and blood flow at the left ventricular inflow tract indicated that, in nine of the total 15 cases, @entity3 disappeared from the cardiac cycle even with sufficient preceding RF in the other six cases (Group B). 2. In Group A, %RF correlated well with % @entity3 ; however, there was poor correlation between them in Group B. Moreover, @entity3 was always greater than 26% if RF was greater than 50% of each mean value in Group A, but less than 25% in Group B, suggesting poor left ventricular ejection in the latter group. 3. The left ventricular ejection fraction (EF) and %fractional shortening (%FS) decreased significantly in Group B compared to those in Group A (EF; 59 +- 7 vs 41 +- 12%, p less than 0.01, %FS; 31 +- 5 vs 20 +- 6, p less than 0.01). These findings indicate that left ventricular contractility was significantly reduced in the cases with @entity1 in Group B. 4. Systolic backward flow in the mid-ventricle caused by left ventricular asynchrony due to localized apical wall motion abnormalities was observed in all 15 cases. The heart rate during pulsed Doppler echocardiography was significantly increased in Group A as compared to that in Group B.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Mechanism of production of @entity1 in XXXX : assessment by blood flow dynamics].

answer: @entity2


abstract: Pulse deficit in @entity0 with @entity2 is caused by the reduction of preload. The purpose of this study was to visualize the mechanism in view of blood flow dynamics using pulsed Doppler echocardiography. The subjects were 15 cases with @entity2 and @entity1 , and the results were as follows: 1. Simultaneous recordings of the @entity3 ( @entity3 ) and blood flow at the left ventricular inflow tract indicated that, in nine of the total 15 cases, @entity3 disappeared from the cardiac cycle even with sufficient preceding RF in the other six cases (Group B). 2. In Group A, %RF correlated well with % @entity3 ; however, there was poor correlation between them in Group B. Moreover, @entity3 was always greater than 26% if RF was greater than 50% of each mean value in Group A, but less than 25% in Group B, suggesting poor left ventricular ejection in the latter group. 3. The left ventricular ejection fraction (EF) and %fractional shortening (%FS) decreased significantly in Group B compared to those in Group A (EF; 59 +- 7 vs 41 +- 12%, p less than 0.01, %FS; 31 +- 5 vs 20 +- 6, p less than 0.01). These findings indicate that left ventricular contractility was significantly reduced in the cases with @entity1 in Group B. 4. Systolic backward flow in the mid-ventricle caused by left ventricular asynchrony due to localized apical wall motion abnormalities was observed in all 15 cases. The heart rate during pulsed Doppler echocardiography was significantly increased in Group A as compared to that in Group B.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Mechanism of production of XXXX in @entity2 : assessment by blood flow dynamics].

answer: @entity1


abstract: PURPOSE: The purpose of this guideline is to provide a clinical framework for the diagnosis and treatment of @entity1 . MATERIALS AND METHODS: A systematic review of the literature using the PubMed  , EMBASE   and Cochrane databases (search dates 1/1/1965 to 1/26/15) was conducted to identify peer-reviewed publications relevant to the diagnosis and treatment of @entity2 . The review yielded an evidence base of 303 articles after application of inclusion/exclusion criteria. RESULTS: The systematic review was used to create guideline statements regarding treatment of @entity2 . When sufficient evidence existed, the body of evidence for a particular treatment was assigned a strength rating of A (high quality evidence; high certainty), B (moderate quality evidence; moderate certainty), or C (low quality evidence; low certainty). Evidence-based statements of Strong, Moderate, or Conditional Recommendation were developed based on benefits and risks/burdens to @entity0 . Additional consensus statements related to the diagnosis of @entity2 are provided as Clinical Principles and Expert Opinions due to insufficient published evidence. CONCLUSIONS: There is a continually expanding literature on @entity2 ; the Panel notes that this document constitutes a clinical strategy and is not intended to be interpreted rigidly. The most effective approach for a particular @entity0 is best determined by the individual clinician and @entity0 in the context of that @entity0 's history, values, and goals for treatment. As the science relevant to @entity2 evolves and improves, the strategies presented here will be amended to remain consistent with the highest standards of clinical care.

title: XXXX : AUA Guideline.

answer: @entity1


abstract: In @entity1 ( @entity1 ) clinical staging systems provide useful tools for establishing the prognosis and to plan therapy. Clinical staging systems, however, do not give information regarding disease progression. In this study the progression and survival of @entity1 in early clinical stages is analyzed. Among 261 @entity0 with @entity1 , 134 (51%) were in stage A (M 60/F 74; mean age 64.2 years; DS = 11), and 87 (33%) in stage 0. Progression was analyzed as far as @entity0 remained untreated (median: 11 months; range: 3-114). Thirty-three (24.6%) out of 134 @entity0 in stage A progressed to more advanced stages (17 to B, 16 to C) with an actuarial cumulative risk for progression of 31% at 3 years. Variables at diagnosis predictive of a more likely progression were: number of lymph nodes involved (p less than 0.001), rapid lymphocyte doubling time (p = 0.0025), and markedly increased lymphocyte count (p = 0.02). Twenty-eight (32%) out of 87 @entity0 in stage 0 progressed (8 to I, 12 to II, 7 to III), the actuarial cumulative risk being of 28% at 3 years. The only variable predictive of progression was a lower normal Hb level (p = 0.015). Although the survival probability of @entity0 in stage A (0) was not statistically different from those in stage A (I, II), their median survivals were of 125.7 and 91 months, respectively. Concerning survival, the following poor prognostic variables were identified: stage A: advanced age (p = 0.01), and rapid lymphocyte doubling time (p = 0.0045). Stage 0: higher lymphocyte count (p = 0.005), and lower normal Hb level (p = 0.015).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Natural history of XXXX : on the progression and progression and prognosis of early clinical stages.

answer: @entity1


abstract: UNASSIGNED: Nanopipettes are an attractive single-molecule tool for identification and characterisation of nucleic acids and proteins in solutions. They enable label-free analysis and reveal individual molecular properties, which are generally masked by ensemble averaging. Having control over the pore dimensions is vital to ensure that the dimensions of the molecules being probed match those of the pore for optimization of the signal to noise. Although nanopipettes are simple and easy to fabricate, challenges exist, especially when compared to more conventional solid-state analogues. For example, a sub-20 nm pore diameter can be difficult to fabricate and the batch-to-batch reproducibility is often poor. To improve on this limitation, @entity0 ( @entity0 ) is used to deposit ultrathin layers of @entity1 ( @entity2 ) on the surface of the quartz nanopipettes enabling sub-nm tuning of the pore dimensions. Here, @entity2 with a thickness of 8, 14 and 17 nm was deposited onto pipettes with a starting pore diameter of 75    5 nm whilst a second batch had 5 and 8 nm @entity2 deposited with a starting pore diameter of 25    3 nm respectively. This highly conformal process coats both the inner and outer surfaces of pipettes and resulted in the fabrication of pore diameters as low as 7.5 nm. We show that @entity2 modified pores do not interfere with the sensing ability of the nanopipettes and can be used for high signal-to-noise DNA detection. @entity0 provides a quick and efficient (batch processing) for fine-tuning nanopipettes for a broad range of applications including the detection of small biomolecules like RNA, aptamers and DNA-protein interactions at the single molecule level.

title: Fine tuning of nanopipettes using XXXX for single molecule sensing.

answer: @entity0


abstract: PURPOSE: To determine whether @entity2 ( @entity2 ) @entity0 with @entity5 ( @entity5 ) have different clinical, polysomnographic, and continuous positive airway pressure (CPAP) titration findings compared to @entity2 @entity0 without @entity5 . METHODS: We retrospectively reviewed the records of @entity2 @entity0 who had undergone CPAP titration and categorized them into pure-OSA and mixed-OSA groups. Demographic features, @entity1 , and @entity4 severity were compared between the two groups using univariate and multivariate analyses. CPAP titration findings were also compared between the two groups. RESULTS: One hundred and ninety-five subjects (n=126 pure-OSA; n=69 mixed-OSA) were included in the analysis. Compared to the pure-OSA group, the mixed-OSA group had a higher percentage of males (p=0.003) and a higher body mass index (p=0.044), Epworth Sleepiness Scale score (p=0.028), and @entity2 index (AHI) (p<0.001). In logistic regression analysis, older age, male sex, and higher body mass index were independently associated with mixed-OSA before PSG study. When using AHI as a covariable, the higher AHI with older age, male sex, and @entity1 was independently related to mixed-OSA. The mixed-OSA group had a higher percentage of @entity0 with @entity5 , a lower percentage of @entity0 with optimal titration, and a higher titrated pressure than the pure-OSA group. CONCLUSIONS: Severe OSA, older age, male sex, @entity3 , and @entity1 were related to mixed-OSA. @entity5 , less optimal titration, and a higher titrated CPAP were also associated with @entity5 in @entity2 @entity0 .

title: Clinical, polysomnographic, and CPAP titration features of XXXX : Mixed versus purely obstructive type.

answer: @entity2


abstract: PURPOSE: The aim of this research was to explore educators' perceptions of a virtual world Second Life TM as an environment for social interaction and social inclusion for the Norwegian adult students with @entity1 that they supported. METHOD: Five educators who supported a total of 10 adult students with @entity1 in computer classes in community Adult Education Centres participated in individual in-depth interviews. The interviews were transcribed verbatim and analysed using a content analysis. RESULTS: @entity0 were positive about Second Life although they did not perceive that it offered a successful context for social interaction or inclusion. They identified a number of benefits to using a virtual world and for students participating in virtual world research. Barriers identified included language, literacy, and technology issues along with the complexity of participating independently in a virtual world. CONCLUSIONS: Some @entity0 with @entity1 can use virtual worlds but the skills required need additional research. Virtual worlds may provide a stimulating, safe, and exciting context for a range of activities but the level of support required by many @entity0 is high and consequently expensive. Implications for Rehabilitation Educators can use virtual worlds such as Second LifeTM with @entity0 with @entity1 as an enjoyable medium to experience new activities and gain feelings of independence. @entity0 with @entity1 can use Second Life with support and those with good literacy and computer skills can be trained to use it independently. Technology support is needed as virtual worlds are not easy to use for those who have problems with literacy or with speaking or reading English and if the virtual world platform is not stable, the ensuing problems with sound and/or images can be frustrating. Further research is required to explore how virtual worlds could be used to expand teaching programs and allow individuals to build on independent and new experiences in the virtual world safely.

title: Teachers' perceptions of virtual worlds as a medium for social inclusion for adults with XXXX .

answer: @entity1


abstract: UNASSIGNED: Romiplostim is recommended for the second- and third-line treatment of primary @entity4 ( @entity4 ). We conducted a large, single-arm study (clinicaltrials.gov; NCT00508820) with broad entry criteria to evaluate the safety of romiplostim in adult @entity4 . @entity0 (n = 407) with @entity4 lasting 0.03-57.14 years and low platelet counts (median 14.0 * 10(9)/l) or uncontrolled @entity1 received romiplostim for up to 4 years. The rates of treatment-related, serious adverse events, serious @entity1 events, @entity2 events and fatal events were similar to those reported in previous romiplostim trials (0.2, 0.4, 0.2 and 0.1/100 @entity0 -weeks, respectively). Bone marrow reticulin was observed in 4 @entity0 , but biopsies were not routinely performed so the true incidence of this event cannot be determined. Type I collagen (nonserious, unrelated) was reported in 1 @entity0 who likely had @entity3 . No new class of adverse events was reported. Platelet responses were achieved by >90% of the @entity0 , typically within 1-2 weeks of the initiation of @entity5 treatment. From week 8, median platelet counts were >100 * 10(9)/l; 47% of the @entity0 received rescue medications (the use decreased over time). This study confirms and extends the tolerability/efficacy findings of previous romiplostim clinical studies. It was performed on a large @entity4 population, which is likely more representative of clinical practice.    2015 S. Karger AG, Basel.

title: Romiplostim Treatment in Adults with XXXX of Varying Duration and Severity.

answer: @entity4


abstract: A case is reported of isolated @entity7 occurring during the removal of two hydatid cysts in the same @entity0 at the same time. This 44 year old @entity0 already had had a hydatid cyst removed one year previously; no complication had occurred at the time. The @entity0 had a past history of @entity3 , easily treated by @entity5 spray. All went well until the first cyst was manipulated: the ventilating pressures rose, and wheezing rhonchi appeared in both lung fields. This @entity7 was resistant to an increase in anaesthetic depth, to @entity5 , @entity6 , @entity2 and 3% @entity4 for 15 min. It however disappeared completely as soon as the cyst was removed. There were no other signs of an anaphylactic reaction. The same thing occurred during the removal of the second cyst. Postoperative investigations showed the @entity0 to be sensitized to house dust and mites. His @entity3 is confirmed. Allergologic tests showed no reaction with the anaesthetic drugs used, but a @entity1 to the echinococcal antigens. The @entity7 was probably due to the increased bronchial sensitivity of this @entity0 .

title: [Peroperative XXXX during surgery of hydatid cysts].

answer: @entity7


abstract: This study aimed to evaluate the dynamic computed tomographic (CT) appearance of focal @entity3 to cirrhotic liver tissue around the @entity1 following stereotactic body radiation therapy (SBRT) for @entity2 ( @entity2 ). Seventy-seven @entity0 with 92 HCCs were observed for >6 months. Sixty-four and 13 @entity0 belonged to @entity0 -Pugh class A and B, respectively. The median SBRT dose was 48 Gy/4fr. Dynamic CT scans were performed in non-enhanced, arterial, portal, and venous phases. The median follow-up period was 18 months. Dynamic CT appearances were classified into 3 types: type 1, hyperdensity in all enhanced phases; type 2, @entity5 in arterial and portal phases; type 3, isodensity in all enhanced phases. @entity4 or 3 appearances significantly changed to type 1, particularly in @entity0 belonging to @entity0 -Pugh class A. After 3-6 months, @entity0 -Pugh class B was a significant factor in type 3 @entity0 . Thus, dynamic CT appearances were classified into 3 patterns and significantly changed over time into the enhancement group (type 1) in most @entity0 belonging to @entity0 -Pugh class A. @entity0 -Pugh class B was a significant factor in the non-enhancement group (type 3).

title: The Time Course of Dynamic Computed Tomographic Appearance of Radiation Injury to the Cirrhotic Liver Following Stereotactic Body Radiation Therapy for XXXX .

answer: @entity2


abstract: BACKGROUND: @entity0 generally prefer to have their family present during medical or nursing interventions. Family presence is assumed to reduce @entity1 , especially during painful interventions. AIM: This study employed a randomized controlled experimental design to determine the effects of family presence on @entity2 and @entity1 during invasive nursing procedures. METHOD: The study population consisted of @entity0 hospitalized in the observation unit of the internal medicine section in the emergency department of a university hospital. The sample comprised 138 @entity0 assigned into the experimental and control groups by drawing lots. The invasive nursing procedure was carried out in the presence of family members, for members of the experimental group, and without family members, for members of the control group. Thus, the effects of family presence on @entity2 and @entity1 during the administration of an invasive nursing procedure to @entity0 were analyzed. RESULTS: The results showed that members of the experimental and control groups did not differ with respect to the @entity2 and state @entity1 scores during the intervention. CONCLUSION: Family presence does not influence the @entity0 ' @entity2 and @entity1 during an invasive nursing procedure. Thus, the decision regarding family presence during such procedures should be based on @entity0 preference.

title: Effect of family presence on @entity2 and XXXX during invasive nursing procedures in an emergency department: A randomized controlled experimental study.

answer: @entity1


abstract: BACKGROUND: @entity0 generally prefer to have their family present during medical or nursing interventions. Family presence is assumed to reduce @entity1 , especially during painful interventions. AIM: This study employed a randomized controlled experimental design to determine the effects of family presence on @entity2 and @entity1 during invasive nursing procedures. METHOD: The study population consisted of @entity0 hospitalized in the observation unit of the internal medicine section in the emergency department of a university hospital. The sample comprised 138 @entity0 assigned into the experimental and control groups by drawing lots. The invasive nursing procedure was carried out in the presence of family members, for members of the experimental group, and without family members, for members of the control group. Thus, the effects of family presence on @entity2 and @entity1 during the administration of an invasive nursing procedure to @entity0 were analyzed. RESULTS: The results showed that members of the experimental and control groups did not differ with respect to the @entity2 and state @entity1 scores during the intervention. CONCLUSION: Family presence does not influence the @entity0 ' @entity2 and @entity1 during an invasive nursing procedure. Thus, the decision regarding family presence during such procedures should be based on @entity0 preference.

title: Effect of family presence on XXXX and @entity1 during invasive nursing procedures in an emergency department: A randomized controlled experimental study.

answer: @entity2


abstract: OBJECTIVE: To compare the safety and efficacy of two @entity1 regimens for mid-trimester pregnancy terminations. METHODS: Retrospective analysis of 263 cases of pregnancy terminations with @entity1 between 12 and 24 weeks was performed. Group 1 (total 129 @entity0 ) consisted of @entity0 who were given 200   mcg vaginal @entity1 every 4   h until the abortion, whereas Group 2 @entity0 (total 134 @entity0 ) were given @entity1 as in International Federation of Gynecology and Obstetrics's (FIGO) 2012 recommendation. In case of a previous cesarean section doses were halved in both groups. Primary outcomes of the study were the time to abortion and the total drug dose used. Secondary outcome was the rate of complications. RESULTS: Total dose and time to abortion did not differ between the groups. As for complications, one @entity0 (%0.8) in group 1 developed @entity2 and had hysterotomy. One @entity0 (%0.8) in group 2 had uterine rupture and had total hysterectomy. Two @entity0 in both groups considered failure of induction and terminated with surgery (hysterotomy). Groups did not show difference in induction failure rates. CONCLUSIONS: We respect the presence of dose recommendation stated by the FIGO and found similar results with our recent protocol. Other @entity1 regimens used worldwide should also be compared with this guideline in order to improve its efficacy.

title: Comparison of two XXXX regimens for mid-trimester pregnancy terminations after FIGO's @entity1 dosage recommendation in 2012.

answer: @entity1


abstract: OBJECTIVE: To compare the safety and efficacy of two @entity1 regimens for mid-trimester pregnancy terminations. METHODS: Retrospective analysis of 263 cases of pregnancy terminations with @entity1 between 12 and 24 weeks was performed. Group 1 (total 129 @entity0 ) consisted of @entity0 who were given 200   mcg vaginal @entity1 every 4   h until the abortion, whereas Group 2 @entity0 (total 134 @entity0 ) were given @entity1 as in International Federation of Gynecology and Obstetrics's (FIGO) 2012 recommendation. In case of a previous cesarean section doses were halved in both groups. Primary outcomes of the study were the time to abortion and the total drug dose used. Secondary outcome was the rate of complications. RESULTS: Total dose and time to abortion did not differ between the groups. As for complications, one @entity0 (%0.8) in group 1 developed @entity2 and had hysterotomy. One @entity0 (%0.8) in group 2 had uterine rupture and had total hysterectomy. Two @entity0 in both groups considered failure of induction and terminated with surgery (hysterotomy). Groups did not show difference in induction failure rates. CONCLUSIONS: We respect the presence of dose recommendation stated by the FIGO and found similar results with our recent protocol. Other @entity1 regimens used worldwide should also be compared with this guideline in order to improve its efficacy.

title: Comparison of two @entity1 regimens for mid-trimester pregnancy terminations after FIGO's XXXX dosage recommendation in 2012.

answer: @entity1


abstract: The globular domain NC1 of @entity0 basement membrane collagen IV was isolated from glomerular basement membrane after collagenase digestion by chromatographic purification. The @entity0 NC1 appears as a hexamer of 160 kD by molecular sieve chromatography which migrates as a single molecule at gel electrophoresis without @entity2 ( @entity2 ). Reversible dissociation of the hexamer into monomers and dimers was achieved by 6 M @entity4 - @entity5 , @entity2 , or at pH values less than 4.0. All the subunits of 26 kD, 28 kD, 44 kD, and 50 kD showed reactivity with anti- @entity1 antibodies on immunoblotting. Inhibition-ELISA demonstrated that the intact hexamer also binds to anti- @entity1 antibodies at higher NC1 concentrations. However, dose-response curves indicated an approximately 20-50-fold increase in reactivity after dissociation of the hexamer in 6 M @entity4 - @entity5 . Analysis of thermostability demonstrated that heating for 24 h at 37 degrees C or 56 degrees C did not alter the reactivity to anti- @entity1 antibodies, while reactivity was lost after heating for more than 120 min at 95 degrees C. In contrast to @entity3 NC1 unfolding of the antigen occurs immediately and does not require elevated temperature. Rotary shadowing of @entity0 NC1 at neutral pH revealed homogeneous globules. Distinct but incomplete dissociation into monomers and dimers could be observed at pH 2.5. These in vitro data of the @entity0 NC1 domain give further evidence that most of the @entity6 epitopes are sequestered within the NC1 hexamer and support the hypothesis that production of anti- @entity1 autoantibodies may be initiated after dissociation of the hexamer has been induced, possibly by a toxic or infective episode.

title: Immunological properties of the @entity0 XXXX target antigen.

answer: @entity6


abstract: The globular domain NC1 of @entity0 basement membrane collagen IV was isolated from glomerular basement membrane after collagenase digestion by chromatographic purification. The @entity0 NC1 appears as a hexamer of 160 kD by molecular sieve chromatography which migrates as a single molecule at gel electrophoresis without @entity2 ( @entity2 ). Reversible dissociation of the hexamer into monomers and dimers was achieved by 6 M @entity4 - @entity5 , @entity2 , or at pH values less than 4.0. All the subunits of 26 kD, 28 kD, 44 kD, and 50 kD showed reactivity with anti- @entity1 antibodies on immunoblotting. Inhibition-ELISA demonstrated that the intact hexamer also binds to anti- @entity1 antibodies at higher NC1 concentrations. However, dose-response curves indicated an approximately 20-50-fold increase in reactivity after dissociation of the hexamer in 6 M @entity4 - @entity5 . Analysis of thermostability demonstrated that heating for 24 h at 37 degrees C or 56 degrees C did not alter the reactivity to anti- @entity1 antibodies, while reactivity was lost after heating for more than 120 min at 95 degrees C. In contrast to @entity3 NC1 unfolding of the antigen occurs immediately and does not require elevated temperature. Rotary shadowing of @entity0 NC1 at neutral pH revealed homogeneous globules. Distinct but incomplete dissociation into monomers and dimers could be observed at pH 2.5. These in vitro data of the @entity0 NC1 domain give further evidence that most of the @entity6 epitopes are sequestered within the NC1 hexamer and support the hypothesis that production of anti- @entity1 autoantibodies may be initiated after dissociation of the hexamer has been induced, possibly by a toxic or infective episode.

title: Immunological properties of the XXXX @entity6 target antigen.

answer: @entity0


abstract: BACKGROUND: Although the @entity0 placenta is considered medical wastes, it has become a main source of stem cells. Due to their easy isolation, ability to resist immune rejection and ability to differentiate into different types of adult cells, placental stem cells are considered superior to other stem cells. OBJECTIVES: This study aimed to assess the impact of the maternal age on the expression of mesenchymal stem cell (MSC) markers CD105 and @entity1 in different areas of a term @entity0 placenta and to identify the differential expression of these markers in different placental areas. SUBJECTS AND METHODS: In this comparative cross sectional study, one hundred term placentas were collected after delivery from healthy mothers divided into five groups according to their age. Placentas were processed to assess both immune- and gene-expression of CD105 and @entity1 surface antigen markers. Data of the different studied age groups was compared using the Statistical Package of Social Science (SPSS) software. RESULTS: CD105 and @entity1 immunoexpression in decidua basalis, fetal membrane and placental villi showed significant negative correlations with the maternal age. CD105- and @entity1 -positive MSCs were significantly abundant in the decidua basalis and placental villi. Real-time polymerase chain reaction results were consistent with those of the immunohistochemical study. CONCLUSION: Labeling the placenta-driven MSCs with the specific area from which the cells were taken as well as the mother's age is advised and could be helpful in controlling the quality of the cell banks as well as the favorable outcome of the therapeutic applications.

title: Does the maternal age affect the mesenchymal stem cell markers and gene expression in the XXXX placenta? What is the evidence?

answer: @entity0


abstract: AIMS: Interstitial @entity0 + cells and T lymphocytes have previously been demonstrated within @entity5 ( @entity5 ). This study investigated the expression of B and T lymphocyte markers by the @entity0 + population, and the expression of @entity3 , a marker of thymocyte progenitors, which have the ability to give rise to both B and T cells. METHODS: Immunohistochemical (IHC) staining was performed on proliferating and involuted IHs for the expression of @entity0 , CD3, @entity1 , @entity4 , @entity3 and @entity2 . The presence of mRNA corresponding to @entity0 , @entity7 , @entity1 and @entity3 was confirmed by reverse transcriptase-polymerase chain reaction in snap-frozen @entity5 tissues. Cell counting of @entity6 IHC-stained slides was performed on @entity0 + only cells and dually stained @entity0 +/CD3+ cells or @entity0 +/ @entity1 + cells and analysed statistically. In situ hybridisation and mass spectrometry were also performed to confirm the presence and abundance of @entity3 , respectively. RESULTS: IHC staining showed a subpopulation of @entity0 + interstitial cells that expressed the T lymphocyte marker, CD3, and another subpopulation that expressed the B lymphocyte marker, @entity1 , in proliferating and diminished in involuted IHs. The abundant expression of @entity3 on the endothelium of proliferating, but not involuted @entity5 , was demonstrated by IHC staining and confirmed by in situ hybridisation and mass spectrometry. CONCLUSIONS: Both B and T lymphocytes are present within the interstitium of proliferating and involuted @entity5 . The expression of @entity3 by the endothelium suggests that B and T cells in @entity5 may have originated from within the lesion, rather than migrating from the peripheral circulation.

title: Characterisation of lymphocyte subpopulations in XXXX .

answer: @entity5


abstract: OBJECTIVE: We assessed the safety and efficacy of administration of pegfilgrastim on the same day compared with standard administration 24 to 72 hours after chemotherapy in @entity0 with gynecologic @entity1 . METHODS: A retrospective review was conducted on @entity0 undergoing pegfilgrastim to mitigate the myelosuppressive consequences of chemotherapy. The primary outcome was incidence of grade 3 to 4 @entity4 following pegfilgrastim for same-day administration (D1) versus standard administration (D2+). Secondary outcomes included dose delay, regimen change, hospitalization due to @entity4 , and incidence of @entity4 . RESULTS: Four hundred twenty-one @entity0 with 2071 administrations of pegfilgrastim were included. Five hundred six administrations of pegfilgrastim were given on D1 compared with 1565 administrations on D2+. The most common @entity1 was @entity2 (79.1%), followed by endometrial (14.5%). Comparing the D1 and D2+ cohorts, noninferiority was not established for the incidence of grade 3 to 4 @entity4 (2.6% vs 1.8%, adjusted relative risk [aRR], 1.6; 90% confidence interval [CI], 0.87-3.2) or dose modification (6.5% vs 4.9%; aRR, 1.3; 90% CI, 0.9-1.8). However, the rate of treatment delays (7.3% vs 9.4%; aRR, 0.8; 90% CI, 0.6-1.1) in the D1 and D2+ groups suggested that delays in the D1 group were not more common than in the D2+ group. CONCLUSIONS: The incidence of hematologic @entity3 and dose modification in @entity0 receiving same-day pegfilgrastim were not as low as in those undergoing standard administration. However, treatment delays were found to be no more frequent in those receiving same-day pegfilgrastim versus standard administration. Same-day administration of pegfilgrastim is a reasonable option.

title: Evaluation of the Hematologic Safety of Same Day Versus Standard Administration (24- to 72-Hour Delay) of Pegfilgrastim in Gynecology Oncology XXXX Undergoing Cytotoxic Chemotherapy.

answer: @entity0


abstract: BACKGROUND AND PURPOSE: @entity1 and @entity6 are @entity5 with similar CNS inflammatory and neurodegenerative characteristics. Our aim was to investigate white matter tract changes and their association with cognitive function in @entity0 with @entity1 and those with @entity6 compared with healthy controls by using diffusion tensor imaging. MATERIALS AND METHODS: Thirty @entity0 with relapsing-remitting @entity1 and 23 @entity0 with @entity6 matched for disease severity and duration and 43 healthy controls were scanned with 3T MR imaging. The DTI was postprocessed, corrected for lesions, and analyzed with tract-based spatial statistics. Cognitive assessment included examination of processing speed; @entity3 ; and sustained attention and executive function. Differences were considered significant at P < .05. RESULTS: Tract-based spatial statistics analysis revealed significantly decreased fractional anisotropy and increased mean diffusivity in @entity0 with @entity1 compared with healthy controls, decreased fractional anisotropy in @entity0 with @entity1 compared with those with @entity6 , and an increased mean diffusivity in @entity0 with @entity6 compared with healthy controls. @entity0 with @entity1 showed decreased fractional anisotropy throughout central WM pathways, including the corpus callosum and the inferior @entity4 compared with those with @entity6 . Altered cognitive scores in @entity0 with @entity1 were significantly associated with decreased fractional anisotropy and increased mean diffusivity in all examined domains, while in @entity0 with diffuse @entity6 , only decreased fractional anisotropy in the superior WM pathways showed significant association with executive function. CONCLUSIONS: @entity0 with @entity1 and @entity6 showed widespread WM tract alterations outside overt lesions, though more severe changes were identified in @entity0 with @entity1 . The WM tract changes were associated with @entity2 in all explored domains only in @entity0 with @entity1 .

title: Cognitive and White Matter Tract Differences in XXXX and Diffuse @entity6 .

answer: @entity1