abstract: BACKGROUND: Management for early onset @entity2 has recently changed, with the development of new surgical procedures. However, multiple surgeries are often required and high complication rates are still reported. Conservative management remains an alternative, serial casting achieving excellent results in young @entity0 . Better compliance and improvement over natural history have been reported with night-time bracing in @entity1 ( @entity1 ), but this treatment has never been reported in early onset @entity3 (EIOS). METHODS: All @entity0 treated for progressive EOIS by detorsion night-time bracing (DNB), and meeting the @entity2 ( @entity2 ) criteria for brace studies were reviewed. Recommendations were given to wear the DNB 8h/night and no restriction was given regarding sports activities. Radiological parameters were compared between referral and latest follow-up. Based on the @entity2 criteria defined for @entity1 , a similar classification was used as follows to analyze the course of the curves: success group: @entity0 with a progression of 5   or less; unsuccess group (progression or failure): @entity0 with a progression>5  , @entity0 with curves exceeding 45   at maturity, or who have had recommendation for/undergone surgery, or @entity0 who changed orthopaedic treatment, or who were lost to follow-up. RESULTS: Thirty-three @entity0 were included (21 @entity0 and 12 @entity0 ), with a median Cobb angle of 31   (Q1-Q3: 22-40). Age at brace initiation averaged 50months (Q1-Q3: 25-60). Median follow-up was 102-months (Q1-Q3: 63-125). Fifteen @entity0 (45.5%) had reached skeletal maturity at last follow-up. The success rate was 67% (22 @entity0 ), with a median Cobb angle reduction of 15   (P<0.001). Four @entity0 stopped DNB due to an important regression. Eleven @entity0 were in the unsuccessful group (33%). Only one had surgery. All @entity0 remained balanced in the frontal plane and normokyphotic. Initial curve magnitude and age at brace initiation appeared to be important prognostic factors. CONCLUSIONS: DNB is an effective conservative treatment, which can be considered a delaying tactic in the management of EOIS. This brace offers potential psychosocial and compliance benefits, and allows unconstrained spinal and chest wall growth, resulting in normokyphosis at maturity. LEVEL OF EVIDENCE: Therapeutic study (retrospective consecutive case series): Level IV.

title: Detorsion night-time bracing for the treatment of early onset XXXX .

answer: @entity3


abstract: BACKGROUND: Laccases are @entity2 -containing enzymes that catalyze the oxidation of a wide variety of phenolic substrates. METHODS: We describe the first poriferan laccase from the marine demosponge @entity6 . RESULTS: This enzyme comprises three characteristic multicopper oxidase homologous domains. Immunohistological studies revealed that the highest expression of the laccase is in the surface zone of the animals. The expression level of the laccase gene is strongly upregulated after exposure of the animals to the bacterial endotoxin lipopolysaccharide. To allow the binding of the recombinant enzyme to ferromagnetic nanoparticles, a recombinant laccase was prepared which contained in addition to the His-tag, a @entity0 -tag at the N-terminus of the enzyme. The recombinant laccase was enzymatically active. The apparent Michaelis constant of the enzyme is 114 M, using @entity4 as substrate. Exposure of @entity1 to the nanoparticles, coated with @entity0 -tagged laccase, and to the mediator @entity5 in the presence of lignin, as the oxidizable substrate, resulted in an almost complete inhibition of colony formation. Quantitative studies of the effect of the laccase-coated @entity3 nanoparticles were performed using @entity1 grown in suspension in reaction tubes within a magnetic nanoparticle separator. CONCLUSIONS: This newly designed magnetic nanoparticle separator allowed a removal of the nanoparticles after terminating the reaction. Using this system, a strong dose-dependent inhibition of the growth of @entity1 by the laccase @entity3 nanoparticles was determined. GENERAL SIGNIFICANCE: From our data we conclude that the sponge laccase is involved in the anti-bacterial defense of the sponge organism.

title: Potential biological role of laccase from the sponge XXXX as an antibacterial defense component.

answer: @entity6


abstract: A novel @entity6 ligand was synthesized by the condensation reaction of @entity16 and @entity15 in @entity3 and characterised by its melting point, elemental analysis, FT-IR, (1)H, @entity9 NMR and mass spectroscopic studies. Molecular structure of the ligand was determined by single crystal X-ray diffraction technique. The electrochemical properties of the @entity6 ligand were studied in different solvents at various scan rates. Sensor ability of the @entity6 ligand was investigated by colorimetric and fluorometric methods. Visual colour change of the ligand was investigated in @entity3 solvent in presence of various metal ions Na(+), @entity2 , @entity14 , K(+), @entity8 , @entity5 , @entity1 , @entity0 , @entity7 , @entity11 , @entity10 , @entity4 , @entity12 and @entity13 . Upon addition of @entity14 ion into a @entity3 solution of the ligand, an orange colour developed which is detectable by naked eye. Fluorescence emission studies showed that the ligand showed single emission band at 630-665nm upon excitation at 560nm. Addition of metal ions Na(+), @entity2 , K(+), @entity8 , @entity5 , @entity1 , @entity0 , @entity7 , @entity11 , @entity10 , @entity4 , @entity12 and @entity13 (1:1M ratio) cause fluorescence quenching, however addition of @entity14 resulted in an increase in fluorescence intensity. No significant variation was observed in the fluorescence intensity caused by @entity14 in presence of other metal ions. Therefore, the @entity6 ligand can be used for selective detection of @entity14 ions in the presence of the other metal ions studied.

title: A novel XXXX : Synthesis, structural characterisation and comparative sensor studies for metal ion detections.

answer: @entity6


abstract: INTRODUCTION: @entity1 is a serious disease, which could be potentially lethal. All cases are observed in @entity0 inadequately immunized. The immunochromatographic tests (including Tetanos quick Stick(  ) [TQS]) have demonstrated their efficiency in emergency setting. The aim of our study was to assess the usefulness of these tests in elderly outpatients seen in ambulatory settings. MATERIALS: This prospective study included @entity0 aged 65 years and over who presented to the outpatients' clinic of the Gerontologic Departmental Center (Marseille). A TQS and a self-administered questionnaire to assess risk factors for @entity1 were performed. RESULTS: One hundred and twenty-two @entity0 were studied. The prevalence of positive TQS was 66%. @entity0 have an average of 2.5 risk factors for @entity1 . Negative TQS was observed in 35% of @entity0 who had seen their general practitioner for a wound during the previous year. CONCLUSION: Elderly @entity0 accumulate several risk factors regardless of age and lifestyle. While physicians are familiar with the vaccine recommendations, they are often faced with the difficulty of assessing @entity0 's status based only on the @entity0 's interview, which is frequently not reliable. The implementation of immunochromatographic tests in general practice could help physicians in the management of @entity0 at risk for @entity1 .

title: [ XXXX risk assessment in the older outpatients: Usefulness of the "T  tanos Quick Stick(  ")?]

answer: @entity1


abstract: BACKGROUND: More than 90% of @entity1 ( @entity1 ) @entity0 show homozygous deletion of @entity2 ( @entity2 ). They retain @entity3 , a highly homologous gene to @entity2 , which may partially compensate for deletion of @entity2 . Although the promoter sequences of these two genes are almost identical, a GCC insertion polymorphism has been identified at c.-320_-321 in the @entity2 promoter. We have also found this insertion polymorphism in an @entity3 promoter in an @entity1 @entity0 ( @entity0 A) who has @entity1 type 2/3. PURPOSE: The aims of this study were to determine the frequency of the GCC insertion polymorphism in @entity1 @entity0 , and to evaluate its effect on SMN transcription efficiency. @entity0 AND METHODS: Fifty-one @entity1 @entity0 , including @entity0 A, were involved in this study. @entity3 transcript levels in white blood cells were measured by real-time polymerase chain reaction. Screening of the GCC insertion polymorphism was performed using denaturing high-pressure liquid chromatography. The transcription efficiency of the promoter with the insertion mutation was evaluated using a reporter-gene assay. RESULTS: All @entity1 @entity0 in this study were homozygous for @entity2 deletion. @entity0 A retained two copies of @entity3 , and showed only a small amount of @entity3 transcript in white blood cells. We detected a GCC insertion polymorphism at c.-320_-321 only in @entity0 A, and not in 50 other @entity1 @entity0 . The polymorphism had a slight but significant negative effect on transcription efficiency. DISCUSSION AND CONCLUSION: @entity0 A was judged to be an exceptional case of @entity1 , because the GCC insertion polymorphism rarely exists in @entity2 -deleted @entity1 @entity0 . The GCC insertion polymorphism did not enhance the transcriptional efficiency of @entity3 . Thus, this GCC insertion polymorphism in the @entity3 promoter may not be associated with the milder phenotype of the @entity0 . @entity0 A suggests that there are other unknown factors modifying the clinical phenotype of @entity1 .

title: Trinucleotide insertion in the @entity3 promoter may not be related to the clinical phenotype of XXXX .

answer: @entity1


abstract: BACKGROUND: More than 90% of @entity1 ( @entity1 ) @entity0 show homozygous deletion of @entity2 ( @entity2 ). They retain @entity3 , a highly homologous gene to @entity2 , which may partially compensate for deletion of @entity2 . Although the promoter sequences of these two genes are almost identical, a GCC insertion polymorphism has been identified at c.-320_-321 in the @entity2 promoter. We have also found this insertion polymorphism in an @entity3 promoter in an @entity1 @entity0 ( @entity0 A) who has @entity1 type 2/3. PURPOSE: The aims of this study were to determine the frequency of the GCC insertion polymorphism in @entity1 @entity0 , and to evaluate its effect on SMN transcription efficiency. @entity0 AND METHODS: Fifty-one @entity1 @entity0 , including @entity0 A, were involved in this study. @entity3 transcript levels in white blood cells were measured by real-time polymerase chain reaction. Screening of the GCC insertion polymorphism was performed using denaturing high-pressure liquid chromatography. The transcription efficiency of the promoter with the insertion mutation was evaluated using a reporter-gene assay. RESULTS: All @entity1 @entity0 in this study were homozygous for @entity2 deletion. @entity0 A retained two copies of @entity3 , and showed only a small amount of @entity3 transcript in white blood cells. We detected a GCC insertion polymorphism at c.-320_-321 only in @entity0 A, and not in 50 other @entity1 @entity0 . The polymorphism had a slight but significant negative effect on transcription efficiency. DISCUSSION AND CONCLUSION: @entity0 A was judged to be an exceptional case of @entity1 , because the GCC insertion polymorphism rarely exists in @entity2 -deleted @entity1 @entity0 . The GCC insertion polymorphism did not enhance the transcriptional efficiency of @entity3 . Thus, this GCC insertion polymorphism in the @entity3 promoter may not be associated with the milder phenotype of the @entity0 . @entity0 A suggests that there are other unknown factors modifying the clinical phenotype of @entity1 .

title: Trinucleotide insertion in the XXXX promoter may not be related to the clinical phenotype of @entity1 .

answer: @entity3


abstract: @entity1 is a heterogeneous malignant process, which is further classified into @entity6 ( @entity6 ) and @entity1 ( @entity1 ). The poor prognosis of the disease is partly due to the lack of understanding of the disease mechanism. Multiple gene alterations identified by various molecular techniques have been described recently. As a result, multiple targeted therapies for @entity6 and @entity1 are being developed. In this study, we identified and compared somatic mutations in @entity6 and @entity1 @entity0 using next generation sequencing (NGS) (Ampliseq Cancer Hotspot Panel v2 and Ion Torrent 318v2 chips). Eleven of 16 samples passed internal quality control established for NGS testing. @entity6 cases (n=3) showed @entity3 (33.3%) and @entity7 (33.3%) mutations. Meanwhile, @entity4 (75%), @entity5 (50%), and @entity2 (12.5%) mutations were identified in @entity1 cases (n=8). Our study confirmed the molecular heterogeneity of @entity6 and @entity1 using NGS. This information will be important for individual @entity0 as targeted therapies for @entity6 and @entity1 become available in the future.

title: Molecular profiling of XXXX using next generation sequencing.

answer: @entity6


abstract: OBJECTIVE: To investigate the functions of @entity0 periodontal myofibroblast (MFB) in vitro. METHODS: @entity0 periodontal fibroblast (hPDLFs) was cultured and induced to MFB by @entity2 ( @entity2 ). MFB was denoted as the experimental group, whereas the hPDLFs was the control group. The groups were continuously cultured and harvested at 0, 12, 24, 48, and 72 h. The MFB marker a-smooth muscle actin ( @entity1 ) was examined by immunocytochemistry. The expression of fibronectin (FN) between MFB was examined by immunocytochemistry to detect the MFB contact relationship. The mRNA expression levels of @entity1 , collagen (Col) I, and Col III were measured by reverse transcription-polymerase chain reaction (RT-PCT) to analyze extracellular matrix secretion. The protein expression levels of @entity1 and Col I were also assessed by Western blot. RESULTS: The experimental group had significantly higher @entity1 expression than the control group at 0 h (P < 0.001). A positive expression of FN was found between MFB. The experimental group had significantly higher expression levels of Col I and Col III than the control group at 24 h (P < 0.001). CONCLUSION: @entity0 periodontal MFB presents a continuous, high expression of @entity1 . MFB could interact through FN. MFB is significantly capable of extracellular matrix secretion.

title: [Functions of XXXX periodontal myofibroblast in vitro].

answer: @entity0


abstract: INTRODUCTION: Impaired balance control is a hallmark symptom in @entity2 ( @entity2 ). Altered sensory-motor integration contributes to the deficiency. We aimed to determine whether impaired vestibular signal processing added to the disorder. We exposed @entity0 (N = 11; 68  6y) and age-matched healthy subjects (hS: N = 19; 65  11y) on a motion platform in complete darkness to two consecutive forward tilt movements (12 series; N = 24; overall 288 trials) and asked them to indicate which tilt was perceived larger. By combing tilt movements with translations we manipulated vestibular sensory input in order to investigate whether putative impairment resulted from a @entity3 (semicircular canals in 'single- @entity4 -cue-condition', otoliths in 'single-OT-cue-condition') themselves or to a sensory integration failure ('multi-cue-condition'). RESULTS: Tilt discrimination in the multi-cue-condition was inferior in @entity0 compared to hS (p = 0.02). No significant differences between the two groups were found for both single-cue-conditions. Comparison of multi-cue-condition with a prediction resulting from the combination of both single-cue-conditions by optimal observer theory revealed that @entity0 (p = 0.04), in contrast to hS, failed to efficiently combine @entity4 and OT information to improve tilt perception. CONCLUSION: We found that @entity2 @entity0 distinguished forward tilts less precise than hS, suggesting @entity1 . Tilt discrimination in @entity0 , moreover, did not improve as much as in hS in conditions where both @entity4 and OT information was available compared to conditions where only @entity4 or OT cues were activated. The latter provides evidence that tilt misperception in @entity2 most likely results from an integration failure of vestibular signals.

title: Impaired tilt perception in XXXX : a central vestibular integration failure.

answer: @entity2


abstract: Electromagnetic field (EMF) exposures affect many biological systems. The reproducibility of these effects is related to the intensity, duration, frequency, and pattern of the EMF. We have shown that exposure to a specific time-varying EMF can inhibit the growth of malignant cells. Thomas-EMF is a low-intensity, frequency-modulated (25-6 Hz) EMF pattern. Daily, 1 h, exposures to Thomas-EMF inhibited the growth of malignant cell lines including B16-BL6, MDA-MB-231, MCF-7, and HeLa cells but did not affect the growth of non-malignant cells. Thomas-EMF also inhibited B16-BL6 cell proliferation in vivo. B16-BL6 cells implanted in syngeneic C57b @entity1 and exposed daily to Thomas-EMF produced smaller @entity0 than in sham-treated controls. In vitro studies showed that exposure of malignant cells to Thomas-EMF for > 15 min promoted @entity2 influx which could be blocked by inhibitors of voltage-gated T-type @entity2 channels. Blocking @entity2 uptake also blocked Thomas-EMF-dependent inhibition of cell proliferation. Exposure to Thomas-EMF delayed cell cycle progression and altered @entity3 expression consistent with the decrease in cell proliferation. Non-malignant cells did not show any EMF-dependent changes in @entity2 influx or cell growth. These data confirm that exposure to a specific EMF pattern can affect cellular processes and that exposure to Thomas-EMF may provide a potential anti- @entity0 therapy.

title: Inhibition of XXXX cell growth by exposure to a specific time-varying electromagnetic field involves T-type calcium channels.

answer: @entity0


abstract: PURPOSE: Although the lamina cribrosa (LC) is the primary site of @entity0 in @entity1 , adequate methods to image and measure it are currently lacking. Here, we describe a noninvasive, in vivo method of evaluating the LC, based on swept-source optical coherence tomography (SS-OCT), and determine this method's ability to quantify LC thickness. METHODS: This study comprised 54 eyes, including normal (n = 18), @entity1 ( @entity1 ; n = 18), and @entity3 ( @entity3 ; n = 18) eyes. We used SS-OCT to obtain 3 x 3 mm cube scans of an area centered on the optic disc, and then synchronized reconstructed B- and en-face images from this data. We identified the LC in these B-scan images by marking the visible borders of the LC pores. We marked points on the anterior and posterior borders of the LC in 12 B-scan images in order to create a skeleton model of the LC. Finally, we used B-spline interpolation to form a 3D model of the LC, including only reliably measured scan areas. We calculated the average LC thickness (avgLCT) in this model and used Spearman's rank correlation coefficient to compare it with circumpapillary retinal nerve fiber layer thickness (cpRNFLT). RESULTS: We found that the correlation coefficient of avgLCT and cpRNFLT was 0.64 (p < 0.01). The coefficient of variation for avgLCT was 5.1%. AvgLCT differed significantly in the groups (normal: 282.6    20.6  m, @entity1 : 261.4    15.8  m, @entity3 : 232.6    33.3  m). The normal, @entity1 and @entity3 groups did not significantly differ in age, sex, refractive @entity2 (IOP), although the normal and @entity3 groups differed significantly in cpRNFLT and Humphrey field analyzer measurements of mean deviation. CONCLUSION: Thus, our results indicate that the parameters of our newly developed method of measuring LC thickness with SS-OCT may provide useful and important data for @entity1 diagnosis and research.

title: 3D evaluation of the lamina cribrosa with swept-source optical coherence tomography in XXXX .

answer: @entity3


abstract: C57B1/6 @entity0 brain @entity1 levels were depleted by feeding animals a diet containing no @entity4 . When such @entity0 were injected with @entity2 , they were found to lose their righting reflex for significantly longer periods and to have a lower body temperature than control animals. Animals consuming the diet containing no @entity4 metabolized @entity2 more slowly than controls. Although daily injections of @entity5 reinstated @entity2 metabolism to normal, the duration of loss of righting reflex and the @entity3 induced by @entity2 were unaffected by @entity5 pretreatment. @entity4 (75 mg/kg) administered six hours prior to @entity2 injection returned brain @entity1 levels to normal in @entity4 -deprived @entity0 . @entity0 injected with @entity4 were found to respond to @entity2 as did the control animals. When brain @entity2 levels were determined at the time the animals lost their righting reflex and when animals regained their righting reflex, @entity4 -deprived @entity0 were found to regain the righting reflex at the same brain @entity2 levels as those at which such animals lost their righting reflex. @entity4 administration to @entity4 -deprived @entity0 resulted in their regaining the righting reflex at higher @entity2 levels than those at which they lost the reflex. Similar experiments were carried out on C3H/HeJ and DBA/J2 @entity0 . The results indicate that C3H @entity0 developed some acute tolerance while DBA @entity0 failed to develop any acute tolerance. The possibility exists that the strain difference in the degree of sensitivity to @entity2 observed in these @entity0 may be due to differing abilities to develop acute tolerance.

title: Strain differences in the development of acute tolerance to XXXX .

answer: @entity2


abstract: BACKGROUND: For node-positive @entity1 , adjuvant radiotherapy has an established benefit, whereas the impact of chemotherapy is unknown. A National Cancer Data Base (NCDB) analysis was conducted to determine patterns of care and evaluate the survival impact of adjuvant chemotherapy. METHODS: The NCDB was queried for @entity1 @entity0 diagnosed from 1998-2011 who underwent extirpative surgery with confirmed inguinal nodal involvement treated with adjuvant radiotherapy. @entity0 with inadequate follow-up or non-squamous histologies were excluded. Chi-square test, logistic regression analysis, log-rank test and multivariable Cox proportional regression modeling with adjustment using propensity score with inverse probability of treatment weights (IPTW) were conducted to establish factors associated with utilization and survival. RESULTS: A total of 1797 @entity0 were identified: 26.3% received adjuvant chemotherapy and 76.6% had 1-3 involved lymph nodes. Adoption of adjuvant chemotherapy significantly increased over time, from 10.8% in 1998 to 41.0% in 2006 (p<0.001). Lower utilization was seen in older @entity0 , Northeast or Southern facilities, and @entity0 with more extensive nodal dissection, whereas greater number of involved nodes, stage @entity3 and positive surgical margins led to a higher probability of receiving chemotherapy. Unadjusted median survival without and with adjuvant chemotherapy was 29.7months and 44.0months (p=0.001). On IPTW-adjusted Cox proportional regression modeling, delivery of adjuvant chemotherapy resulted in a 38% reduction in the risk of @entity2 (HR 0.62, 95% CI 0.48-0.79, p<0.001). CONCLUSION: In a large population-based analysis, adjuvant chemotherapy resulted in a significant reduction in mortality risk for node-positive @entity1 @entity0 who received adjuvant radiotherapy.

title: Impact of adjuvant chemotherapy with radiation for node-positive XXXX : A National Cancer Data Base (NCDB) analysis.

answer: @entity1


abstract: BACKGROUND: The role of extracorporeal life support (ECLS) in primary @entity6 (PCS) is well established. In this study, we evaluated the impact of etiology on outcomes. METHODS: Between January 2009 and March 2013, we implanted a total of 249 @entity0 with ECLS; we focused on 64 @entity0 for whom peripheral ECLS was the treatment for PCS. Of these, 37 cases (58%) were "acute" (mostly acute @entity4 : 39%); 27 (42%) had an exacerbation of "chronic" @entity5 ( @entity3 : 30%; post- @entity1 @entity2 : 9%; and congenital: 3%). RESULTS: In the group with chronic etiology, 23 @entity0 were bridged to a left ventricular assist device (52%) or heart transplantation (33%). In the group with acute etiology, ECLS was used as a bridge-to-transplantation in 3 @entity0 (8%), a bridge-to-bridge in 9 (24%), and a bridge-to-recovery in 18 (49%). One @entity0 in each group was bridged to conventional surgery. Recovery of cardiac function was achieved in only the group with acute primary @entity6 (18 vs 0 @entity0 , P  =  .0001). A mean flow during support of  <=60% of the theoretic flow (body surface area  *  2.4) was a predictor of successful weaning (P  =  .02). Median duration of ECLS support was 7 days (range: 2-11.5 days). Nine @entity0 (14%) died during support; 30-day overall survival was 80% (51  of 64 @entity0 ); and 59% of @entity0 were discharged, in whom survival at 48 months was 90%. Thirty-day survival was correlated with duration of ECLS support. CONCLUSIONS: In "chronic" @entity5 , ECLS represents a bridge to a ventricular assist device or heart transplantation, whereas in "acute" settings, it offers a considerable chance of recovery, and is often the only required therapy.

title: Extracorporeal life support in XXXX : Impact of acute versus chronic etiology on outcome.

answer: @entity6


abstract: The quantitative relationship between red cell volume, @entity3 level, and erythropoiesis was evaluated in 43 @entity0 beings. Results in normal @entity0 were compared with studies in @entity0 with @entity1 from @entity4 and with @entity5 vera. The maximum @entity3 excretion after @entity2 normal @entity0 was similar to the basal levels found in @entity0 with @entity1 of similar magnitude. Although @entity3 values were low in @entity0 with @entity5 vera, @entity2 evoked a normal response. In @entity0 anemic from @entity4 , basal levels were elevated, and phlebotomy resulted in an increase consistent with the new level of @entity1 . These observations indicate that @entity3 level is affected primarily by the degree of @entity1 and is not influenced by the duration of @entity1 . In normal subjects, a fivefold increase in urinary @entity3 was associated with a doubling of erythropoiesis. Despite similar degrees of @entity3 production, anemic @entity0 with evidence of bone marrow in the lower extremities had greater red cell production. In @entity0 with @entity5 vera, red cell production was inappropriately elevated with regard to the urinary @entity3 excretion. Bone marrow maturation time was not shortened in @entity0 anemic from @entity4 to the same degree as in bled, normal volunteers. In addition to an adequate level of @entity3 production, normal bone marrow function is necessary for maximal shortening of maturation time.

title: Erythropoiesis in the @entity1 of XXXX .

answer: @entity4


abstract: The quantitative relationship between red cell volume, @entity3 level, and erythropoiesis was evaluated in 43 @entity0 beings. Results in normal @entity0 were compared with studies in @entity0 with @entity1 from @entity4 and with @entity5 vera. The maximum @entity3 excretion after @entity2 normal @entity0 was similar to the basal levels found in @entity0 with @entity1 of similar magnitude. Although @entity3 values were low in @entity0 with @entity5 vera, @entity2 evoked a normal response. In @entity0 anemic from @entity4 , basal levels were elevated, and phlebotomy resulted in an increase consistent with the new level of @entity1 . These observations indicate that @entity3 level is affected primarily by the degree of @entity1 and is not influenced by the duration of @entity1 . In normal subjects, a fivefold increase in urinary @entity3 was associated with a doubling of erythropoiesis. Despite similar degrees of @entity3 production, anemic @entity0 with evidence of bone marrow in the lower extremities had greater red cell production. In @entity0 with @entity5 vera, red cell production was inappropriately elevated with regard to the urinary @entity3 excretion. Bone marrow maturation time was not shortened in @entity0 anemic from @entity4 to the same degree as in bled, normal volunteers. In addition to an adequate level of @entity3 production, normal bone marrow function is necessary for maximal shortening of maturation time.

title: Erythropoiesis in the XXXX of @entity4 .

answer: @entity1


abstract: The objective of this study was to assess whether resident exposure to liver transplantation anesthesia results in improved @entity0 care during a simulated critical care scenario. Our hypothesis was that anesthesia residents exposed to liver transplantation anesthesia care would be able to identify and treat a simulated @entity4 crisis after reperfusion more appropriately than residents who have not been involved in liver transplantation anesthesia care. Participation in liver transplantation anesthesia is not a mandatory component of the curriculum of anesthesiology training programs in the United States. It is unclear whether exposure to liver transplantation anesthesia is beneficial for skill set development. A high-fidelity @entity0 @entity0 simulation scenario was developed. Times for administration of @entity2 , @entity5 , and secondary @entity3 treatment were recorded. A total of 25 residents with similar training levels participated: 13 residents had previous liver transplantation experience (OLT), whereas 12 residents had not been previously exposed to liver transplantations (non-OLT). The OLT group performed better in recognizing and treating the @entity4 crisis than the non-OLT group. Pharmacologic therapy for @entity3 was given earlier (OLT 53.3    27.0 seconds versus non-OLT 148    104.1 seconds; P < 0.01) and hemodynamics restored quicker (OLT 87.9    24.9 seconds versus non-OLT 219.9    87.1 seconds; P < 0.01). Simulation-based assessment of clinical skills is a useful tool for evaluating anesthesia resident performance during an intraoperative crisis situation related to liver transplantations. Previous liver transplantation experience improves the anesthesia resident's ability to recognize and treat @entity4 @entity1 .

title: The impact of exposure to liver transplantation anesthesia on the ability to treat intraoperative XXXX : a simulation experience.

answer: @entity3


abstract: BACKGROUND/OBJECTIVES: Mounting evidence supports a link between circadian disruption and @entity4 . @entity0 with circadian disruption (for example, night-shift workers) have an increased risk of @entity2 and @entity3 compared with the non-disrupted population. However, it is unclear whether the @entity2 and @entity2 associated with circadian disruption respond to therapeutic treatments as well as individuals with other types of @entity2 . SUBJECTS/METHODS: Here, we test the effectiveness of the commonly used bariatric surgical procedure, Vertical Sleeve Gastrectomy (VSG), in @entity1 models of genetic and environmental circadian disruption. RESULTS: VSG led to a reduction in body weight and fat mass in both Clock(  19) mutant and constant-light @entity1 models (P<0.05), resulting in an overall metabolic improvement independent of circadian disruption. Interestingly, the decrease in body weight occurred without altering diurnal feeding or activity patterns (P>0.05). Within circadian-disrupted models, VSG also led to improved @entity5 tolerance and lipid handling (P<0.05). CONCLUSIONS: Together these data demonstrate that VSG is an effective treatment for the @entity2 associated with circadian disruption, and that the potent effects of bariatric surgery are orthogonal to circadian biology. However, as the effects of bariatric surgery are independent of circadian disruption, VSG cannot be considered a cure for circadian disruption. These data have important implications for circadian-disrupted @entity2 @entity0 . Moreover, these results reveal new information about the metabolic pathways governing the effects of bariatric surgery as well as of circadian disruption.

title: Metabolic effects of bariatric surgery in XXXX models of circadian disruption.

answer: @entity1


abstract: BACKGROUND: Portion size is an important component of dietary advice for weight control, but little is known about what portion sizes @entity0 consider 'normal'. This study determined the effect of body mass index (BMI), gender, dietary restraint and liking of the food on personal and social portion size norms for a range of foods and the degree of certainty over the norms. METHODS: Thirty lean (BMI 20-25   kg   m(-)(2)) and 30 @entity1 (BMI 30-35   kg   m(-)(2)) @entity0 and @entity0 (aged 18-60 years) viewed 17 different portion sizes of 12 foods on a computer screen on two occasions a week apart. @entity0 responded 'more' or 'less' to each photograph reflecting personal portion size preference or perceived portion sizes of others. Personal and social norms for portion sizes of each food were determined using the method of constant stimuli giving a sigmoidal curve of the probability of answering 'less' over a range of portion sizes. The slope of the sigmoid at the norm gave a measure of certainty about the norm. Regression models were used to examine the effect of BMI, gender, dietary restraint and liking of the food on personal norms, social norms, the relationship between norms, and the slopes. RESULTS: Personal norms were significantly larger in the @entity1 (P=0.026), @entity0 (P<0.001), those with lower dietary restraint (P<0.001), and those with higher liking for the food (P<0.001). Social norms were larger for @entity0 (P=0.012). The slopes at the norms were 30% shallower in the @entity1 and in @entity0 (P<0.001). CONCLUSION: Larger personal norms for portion size among the @entity1 , @entity0 , those with lower dietary restraint and those with higher liking for a food imply greater consumption, which may undermine weight control. Shallower slopes for norms in the @entity1 and in @entity0 may imply less clearly defined habitual portion sizes.

title: Personal and social norms for food portion sizes in lean and XXXX adults.

answer: @entity1


abstract: BACKGROUND/OBJECTIVES: Psychosocial stress has been proposed to contribute to @entity1 , particularly abdominal, or @entity6 , through chronic activation of the neuroendocrine systems. However, these putative relationships are complex and dependent on country and cultural context. We investigated the association between psychosocial factors and general and @entity6 in the Prospective Urban Rural Epidemiologic study. SUBJECTS/METHODS: This observational, cross-sectional study enrolled 151   966 individuals aged 35-70 years from 628 urban and rural communities in 17 high-, middle- and low-income countries. Data were collected for 125   290 individuals regarding education, anthropometrics, @entity2 / @entity0 , @entity4 / @entity3 use, diet and psychosocial factors (self-perceived stress and @entity5 ). RESULTS: After standardization for age, sex, country income and urban/rural location, the proportion with @entity1 (body mass index    30   kg   m(-)(2)) increased from 15.7% in 40   831 individuals with no stress to 20.5% in 7720 individuals with permanent stress, with corresponding proportions for ethnicity- and sex-specific @entity6 of 48.6% and 53.5%, respectively (P<0.0001 for both). Associations between stress and @entity2 / @entity0 tended to be inverse. Estimating the total effect of permanent stress with age, sex, physical activity, education and region as confounders, no relationship between stress and @entity1 persisted (adjusted prevalence ratio (PR) for @entity1 1.04 (95% confidence interval: 0.99-1.10)). There was no relationship between ethnicity- and sex-specific @entity6 (adjusted PR 1.00 (0.97-1.02)). Stratification by region yielded inconsistent associations. @entity5 was weakly but independently linked to @entity1 (PR 1.08 (1.04-1.12)), and very marginally to @entity6 (PR 1.01 (1.00-1.03)). CONCLUSIONS: Although individuals with permanent stress tended to be slightly more @entity1 , there was no overall independent effect and no evidence that @entity6 or its consequences ( @entity2 , @entity0 ) increased with higher levels of stress or @entity5 . This study does not support a causal link between psychosocial factors and @entity6 .

title: Psychosocial factors and XXXX in 17 high-, middle- and low-income countries: the Prospective Urban Rural Epidemiologic study.

answer: @entity1


abstract: UNASSIGNED: Exercise capacity, an objective measure of exercise intolerance, is known to predict quality of life and mortality in @entity4 ( @entity4 ). The mechanisms for exercise intolerance in @entity0 with @entity4 ( @entity4 ), however, have yet to be fully elucidated. Accordingly, this study sought to investigate @entity1 uptake kinetics and the impact of @entity3 ( @entity3 ) on exercise capacity in young @entity0 with @entity4 . 16 young @entity0 with @entity4 (age 13        4 years; 10 female) and 15 matched controls (age 14        3 years; nine female) participated. Pulmonary function and a maximal exercise test on a cycle ergometer using the Godfrey protocol were performed. Exercise capacity ( @entity5 peak), @entity5 response time ( @entity5 @entity2 ), and functional @entity5 gain (  @entity5 /  WR) were all determined. Lung function was the only demographic parameter significantly lower (P   <   0.05) in @entity4 compared to controls. Exercise capacity was lower in @entity4 (P   <   0.014) only when @entity5 peak was normalized for @entity3 (43.5        7.7 vs. 50.6        7.4 @entity3 ) or expressed as % predicted (70.1        14.3 vs. 85.4        16.0%). The @entity5 @entity2 was slower (36.1        15.1 vs. 25.0        12.4   sec; P   =   0.03) and the   @entity5 /  WR slope was lower (8.4        3 ml/min/watt vs. 10.1        1.4 ml/min/watt; P   =   0.02) in @entity0 compared to controls, respectively. In conclusion, a delayed @entity5 response time coupled with the lower functional @entity5 gain (  @entity5 /  WR) suggest that young @entity0 with @entity4 have impairment in @entity1 transport and @entity1 utilization by the muscles. These data in addition to differences in @entity5 peak normalized for @entity3 provide some insight that muscle mass and muscle metabolism contribute to exercise intolerance in @entity4 . Pediatr Pulmonol. 2015; 50:647-654.    2015 Wiley Periodicals, Inc.

title: XXXX uptake kinetics and exercise capacity in @entity0 with @entity4 .

answer: @entity1


abstract: UNASSIGNED: Exercise capacity, an objective measure of exercise intolerance, is known to predict quality of life and mortality in @entity4 ( @entity4 ). The mechanisms for exercise intolerance in @entity0 with @entity4 ( @entity4 ), however, have yet to be fully elucidated. Accordingly, this study sought to investigate @entity1 uptake kinetics and the impact of @entity3 ( @entity3 ) on exercise capacity in young @entity0 with @entity4 . 16 young @entity0 with @entity4 (age 13        4 years; 10 female) and 15 matched controls (age 14        3 years; nine female) participated. Pulmonary function and a maximal exercise test on a cycle ergometer using the Godfrey protocol were performed. Exercise capacity ( @entity5 peak), @entity5 response time ( @entity5 @entity2 ), and functional @entity5 gain (  @entity5 /  WR) were all determined. Lung function was the only demographic parameter significantly lower (P   <   0.05) in @entity4 compared to controls. Exercise capacity was lower in @entity4 (P   <   0.014) only when @entity5 peak was normalized for @entity3 (43.5        7.7 vs. 50.6        7.4 @entity3 ) or expressed as % predicted (70.1        14.3 vs. 85.4        16.0%). The @entity5 @entity2 was slower (36.1        15.1 vs. 25.0        12.4   sec; P   =   0.03) and the   @entity5 /  WR slope was lower (8.4        3 ml/min/watt vs. 10.1        1.4 ml/min/watt; P   =   0.02) in @entity0 compared to controls, respectively. In conclusion, a delayed @entity5 response time coupled with the lower functional @entity5 gain (  @entity5 /  WR) suggest that young @entity0 with @entity4 have impairment in @entity1 transport and @entity1 utilization by the muscles. These data in addition to differences in @entity5 peak normalized for @entity3 provide some insight that muscle mass and muscle metabolism contribute to exercise intolerance in @entity4 . Pediatr Pulmonol. 2015; 50:647-654.    2015 Wiley Periodicals, Inc.

title: @entity1 uptake kinetics and exercise capacity in @entity0 with XXXX .

answer: @entity4


abstract: UNASSIGNED: Exercise capacity, an objective measure of exercise intolerance, is known to predict quality of life and mortality in @entity4 ( @entity4 ). The mechanisms for exercise intolerance in @entity0 with @entity4 ( @entity4 ), however, have yet to be fully elucidated. Accordingly, this study sought to investigate @entity1 uptake kinetics and the impact of @entity3 ( @entity3 ) on exercise capacity in young @entity0 with @entity4 . 16 young @entity0 with @entity4 (age 13        4 years; 10 female) and 15 matched controls (age 14        3 years; nine female) participated. Pulmonary function and a maximal exercise test on a cycle ergometer using the Godfrey protocol were performed. Exercise capacity ( @entity5 peak), @entity5 response time ( @entity5 @entity2 ), and functional @entity5 gain (  @entity5 /  WR) were all determined. Lung function was the only demographic parameter significantly lower (P   <   0.05) in @entity4 compared to controls. Exercise capacity was lower in @entity4 (P   <   0.014) only when @entity5 peak was normalized for @entity3 (43.5        7.7 vs. 50.6        7.4 @entity3 ) or expressed as % predicted (70.1        14.3 vs. 85.4        16.0%). The @entity5 @entity2 was slower (36.1        15.1 vs. 25.0        12.4   sec; P   =   0.03) and the   @entity5 /  WR slope was lower (8.4        3 ml/min/watt vs. 10.1        1.4 ml/min/watt; P   =   0.02) in @entity0 compared to controls, respectively. In conclusion, a delayed @entity5 response time coupled with the lower functional @entity5 gain (  @entity5 /  WR) suggest that young @entity0 with @entity4 have impairment in @entity1 transport and @entity1 utilization by the muscles. These data in addition to differences in @entity5 peak normalized for @entity3 provide some insight that muscle mass and muscle metabolism contribute to exercise intolerance in @entity4 . Pediatr Pulmonol. 2015; 50:647-654.    2015 Wiley Periodicals, Inc.

title: @entity1 uptake kinetics and exercise capacity in XXXX with @entity4 .

answer: @entity0


abstract: @entity8 are frequent in @entity0 with @entity4 . @entity8 depend on the location and the lateralization of the lesion. These disorders are well described in temporal @entity7 but rarely in population with @entity1 and especially not specifically focus on @entity2 . The purpose of this study was to describe neuropsychological examination in @entity0 with @entity2 in the database of the regional memory centre of Besan  on. Four @entity0 were identified (all right-handed and with a left @entity2 ). @entity3 and @entity3 were observed. One @entity0 had also @entity6 . Therefore, further investigations showed an associated @entity5 . This finding modified the clinical management of this @entity0 . Extensive neuropsychological assessment should be systematic initially to seek an associated pathology, especially in elderly @entity0 , if the cognitive profile is unusual, during the follow-up to better understand cognitive evolution and the effect of therapies on cognition.

title: [Mnesic disorders caused by left temporal XXXX ].

answer: @entity2


abstract: UNASSIGNED: Caudal  -related homeobox protein 2 ( @entity8 ), a @entity1 suppressor in the adult colon, is overexpressed under a non  - @entity1 specific @entity6 promoter in certain @entity1 cells; furthermore, non  -specific expression of @entity8 may result in aberrant side effects in normal cells. The @entity0 @entity5 ( @entity5 ) promoter is active in the majority of @entity1 cells but not in normal cells. @entity4 is a key feature of solid @entity1 , and targeted genes may be significantly upregulated by five copies of @entity4  -response elements (HREs) under @entity4 conditions. However, the effect of @entity8 overexpression, as controlled by five copies of HREs and the @entity5 promoter, on @entity0 @entity2 ( @entity2 ) cell proliferation in  vitro remains to be fully elucidated. In the current study, a recombinant lentivirus containing the @entity8 gene under the control of five HREs and the @entity5 promoter was generated. An immunofluorescence assay was used to detect @entity8 expression by the 5HhC lentivirus, whereas an @entity3 assay was used to detect the effects of @entity7 on the viability of LoVo cells. Western blot analysis was conducted in order to determine the relative ratios of recombinant @entity8 protein to the internal control b-actin, following 5HhC/LoVo  cell culture under normoxic and @entity4 conditions (100, 200, 300, 400  or 500    mol/l  @entity7 ) for 24  h, then for 12, 24  or 36  h with the optimal concentration (300    mol/l) of @entity7 . Reverse transcription polymerase chain reaction analysis was used to determine the transcription of recombinant @entity8 mRNA following culture of 5HhC/LoVo cells under normoxic or @entity4 conditions. Finally, a cloning assay was used to detect the proliferative ability of 5HhC/LoVo and 5Hh cells. High @entity8 expression was observed in @entity5  -positive LoVo cells under @entity4 conditions, an effect which was mimicked by treatment with @entity7 to inhibit LoVo  cell proliferation in  vitro. High expression of @entity8 therefore provides a promising strategy for the development of novel targeted treatments and gene therapy for @entity2 .

title: Recombinant lentivirus with enhanced expression of caudal  -related homeobox protein  2 inhibits @entity0 XXXX cell proliferation in  vitro.

answer: @entity2


abstract: UNASSIGNED: Caudal  -related homeobox protein 2 ( @entity8 ), a @entity1 suppressor in the adult colon, is overexpressed under a non  - @entity1 specific @entity6 promoter in certain @entity1 cells; furthermore, non  -specific expression of @entity8 may result in aberrant side effects in normal cells. The @entity0 @entity5 ( @entity5 ) promoter is active in the majority of @entity1 cells but not in normal cells. @entity4 is a key feature of solid @entity1 , and targeted genes may be significantly upregulated by five copies of @entity4  -response elements (HREs) under @entity4 conditions. However, the effect of @entity8 overexpression, as controlled by five copies of HREs and the @entity5 promoter, on @entity0 @entity2 ( @entity2 ) cell proliferation in  vitro remains to be fully elucidated. In the current study, a recombinant lentivirus containing the @entity8 gene under the control of five HREs and the @entity5 promoter was generated. An immunofluorescence assay was used to detect @entity8 expression by the 5HhC lentivirus, whereas an @entity3 assay was used to detect the effects of @entity7 on the viability of LoVo cells. Western blot analysis was conducted in order to determine the relative ratios of recombinant @entity8 protein to the internal control b-actin, following 5HhC/LoVo  cell culture under normoxic and @entity4 conditions (100, 200, 300, 400  or 500    mol/l  @entity7 ) for 24  h, then for 12, 24  or 36  h with the optimal concentration (300    mol/l) of @entity7 . Reverse transcription polymerase chain reaction analysis was used to determine the transcription of recombinant @entity8 mRNA following culture of 5HhC/LoVo cells under normoxic or @entity4 conditions. Finally, a cloning assay was used to detect the proliferative ability of 5HhC/LoVo and 5Hh cells. High @entity8 expression was observed in @entity5  -positive LoVo cells under @entity4 conditions, an effect which was mimicked by treatment with @entity7 to inhibit LoVo  cell proliferation in  vitro. High expression of @entity8 therefore provides a promising strategy for the development of novel targeted treatments and gene therapy for @entity2 .

title: Recombinant lentivirus with enhanced expression of caudal  -related homeobox protein  2 inhibits XXXX @entity2 cell proliferation in  vitro.

answer: @entity0


abstract: UNASSIGNED: A simple efficacious topical treatment for @entity6 ( @entity6 ) is still an unresolved challenge. This study aimed to evaluate the efficacy of the topical use of @entity8 plus @entity9 (Thio-Ben) tincture in combination with cryotherapy in comparison with intralesional @entity7 ( @entity7 ) along with cryotherapy in treating anthroponotic @entity6 (ACL). The study was conducted in @entity3 Center in Dadbin Health Care Clinic, Kerman, Iran. Sixty-four @entity6 lesions were randomly assigned to receive Thio-Ben plus cryotherapy (TC) (n = 32) or @entity7 plus cryotherapy (GC) (n = 32). Thio-Ben was used topically every other day and @entity7 was used intralesionally once a week for a maximum of 3 months. In both study groups, cryotherapy was administered using liquid @entity5 once every 2 weeks. Of 64 recruited lesions, 47 lesions completed the study protocol. Twenty lesions (91%) in TC group and 23 lesions (92%) in GC group showed complete cure. TC group showed faster clinical response. @entity2 , @entity1 , dizziness, and @entity4 were only seen in GC group. This study showed that the topical use of Thio-Ben combined with cryotherapy has a good efficacy in treating ACL with the benefit that Thio-Ben has more @entity0 compliance and less side effects than intralesional @entity7 .

title: The topical treatment of anthroponotic XXXX with the tincture of @entity8 plus @entity9 (Thio-Ben) along with cryotherapy: a single-blind randomized clinical trial.

answer: @entity6


abstract: UNASSIGNED: A simple efficacious topical treatment for @entity6 ( @entity6 ) is still an unresolved challenge. This study aimed to evaluate the efficacy of the topical use of @entity8 plus @entity9 (Thio-Ben) tincture in combination with cryotherapy in comparison with intralesional @entity7 ( @entity7 ) along with cryotherapy in treating anthroponotic @entity6 (ACL). The study was conducted in @entity3 Center in Dadbin Health Care Clinic, Kerman, Iran. Sixty-four @entity6 lesions were randomly assigned to receive Thio-Ben plus cryotherapy (TC) (n = 32) or @entity7 plus cryotherapy (GC) (n = 32). Thio-Ben was used topically every other day and @entity7 was used intralesionally once a week for a maximum of 3 months. In both study groups, cryotherapy was administered using liquid @entity5 once every 2 weeks. Of 64 recruited lesions, 47 lesions completed the study protocol. Twenty lesions (91%) in TC group and 23 lesions (92%) in GC group showed complete cure. TC group showed faster clinical response. @entity2 , @entity1 , dizziness, and @entity4 were only seen in GC group. This study showed that the topical use of Thio-Ben combined with cryotherapy has a good efficacy in treating ACL with the benefit that Thio-Ben has more @entity0 compliance and less side effects than intralesional @entity7 .

title: The topical treatment of anthroponotic @entity6 with the tincture of XXXX plus @entity9 (Thio-Ben) along with cryotherapy: a single-blind randomized clinical trial.

answer: @entity8


abstract: UNASSIGNED: A simple efficacious topical treatment for @entity6 ( @entity6 ) is still an unresolved challenge. This study aimed to evaluate the efficacy of the topical use of @entity8 plus @entity9 (Thio-Ben) tincture in combination with cryotherapy in comparison with intralesional @entity7 ( @entity7 ) along with cryotherapy in treating anthroponotic @entity6 (ACL). The study was conducted in @entity3 Center in Dadbin Health Care Clinic, Kerman, Iran. Sixty-four @entity6 lesions were randomly assigned to receive Thio-Ben plus cryotherapy (TC) (n = 32) or @entity7 plus cryotherapy (GC) (n = 32). Thio-Ben was used topically every other day and @entity7 was used intralesionally once a week for a maximum of 3 months. In both study groups, cryotherapy was administered using liquid @entity5 once every 2 weeks. Of 64 recruited lesions, 47 lesions completed the study protocol. Twenty lesions (91%) in TC group and 23 lesions (92%) in GC group showed complete cure. TC group showed faster clinical response. @entity2 , @entity1 , dizziness, and @entity4 were only seen in GC group. This study showed that the topical use of Thio-Ben combined with cryotherapy has a good efficacy in treating ACL with the benefit that Thio-Ben has more @entity0 compliance and less side effects than intralesional @entity7 .

title: The topical treatment of anthroponotic @entity6 with the tincture of @entity8 plus XXXX (Thio-Ben) along with cryotherapy: a single-blind randomized clinical trial.

answer: @entity9


abstract: BACKGROUND: Although surgery is the standard treatment for early-stage @entity4 ( @entity4 ), stereotactic body radiotherapy (SBRT) has been disseminated as an alternative therapy. The comparative mortalities and @entity3 of these treatments for @entity0 of different life expectancies are unknown. METHODS: The Surveillance, Epidemiology, and End Results-Medicare linked database was used to identify @entity0 who were 67 years old or older and underwent SBRT or surgery for stage I @entity4 from 2007 to 2009. Matched @entity0 were stratified into short life expectancies (<5 years) and long life expectancies (>= 5 years). Mortality and complication rates were compared with Poisson regression. RESULTS: Overall, 367 SBRT @entity0 and 711 surgery @entity0 were matched. Acute @entity3 (0-1 month) was lower from SBRT versus surgery (7.9% vs 54.9%, P   <   .001). At 24 months after treatment, there was no difference (69.7% vs 73.9%, P   =   .31). The incidence rate ratio (IRR) for @entity3 from SBRT versus surgery was 0.74 (95% confidence interval [CI], 0.64-0.87). Overall mortality was lower with SBRT versus surgery at 3 months (2.2% vs 6.1%, P   =   .005), but by 24 months, overall mortality was higher with SBRT (40.1% vs 22.3%, P   <   .001). For @entity0 with short life expectancies, there was no difference in @entity1 mortality (IRR, 1.01; 95% CI, 0.40-2.56). However, for @entity0 with long life expectancies, there was greater overall mortality (IRR, 1.49; 95% CI, 1.11-2.01) as well as a trend toward greater @entity1 mortality (IRR, 1.63; 95% CI, 0.95-2.79) with SBRT versus surgery. CONCLUSIONS: SBRT was associated with lower immediate mortality and @entity3 in comparison with surgery. However, for @entity0 with long life expectancies, there appears to be a relative benefit from surgery versus SBRT. @entity2 2015;121:2341-2349.    2015 American @entity2 Society.

title: Comparative effectiveness of surgery and radiosurgery for stage I XXXX .

answer: @entity4


abstract: PURPOSE: @entity2 ( @entity2 ) is a benign bone @entity1 with considerable recurrence potential. Resection is the mainstay for the treatment of Enneking stage 3 (st. 3) @entity2 . This retrospective study aimed to verify the appropriate surgical strategy for st. 3 lesions in the mobile spine. METHODS: 19 cases of st. 3 @entity2 was diagnosed between 2001 and 2011. Clinical, radiological, surgical, and follow-up data were analyzed. This series included 14 @entity0 and 5 @entity0 and the mean age at diagnosis was 30.4  years. The lesions were located in the cervical spine in ten cases, in the thoracic spine in eight, and in the lumbar spine in one. Fourteen @entity0 were surgically treated for the first time (intact cases), and five were referred to us after previous unsuccessful treatments (non-intact cases). RESULTS: Before 2008, 11 @entity0 underwent curettage followed by radiotherapy, including 5 non-intact cases and 6 intact cases. @entity1 recurrence was observed in all five non-intact cases and four of the six intact cases. After 2008, eight intact @entity0 underwent intralesional vertebrectomy, including six who underwent piecemeal total vertebrectomy and two who underwent intralesional en bloc vertebrectomy. All  the eight @entity0  had  embolization  before  surgery. 18 @entity0 had an average 67.3  months (range 36-148  months) of follow-up. Recurrence was not observed in any of these eight cases with intralesional vertebrectomy. CONCLUSION: Intralesional total vertebrectomy might be an appropriate choice for intact st. 3 @entity2 spine lesions. More cases with longer follow-up periods should be recruited in the future to better understand the treatment options available for this disease.

title: Surgical treatment options for aggressive XXXX in the mobile spine.

answer: @entity2


abstract: The @entity4 , a chronic condition in @entity0 affecting @entity1 and causing @entity3 , is caused by Brucella, a genus of Gram-negative, facultative, intracellular pathogens. The mode of transmission and the virulence of the pathogens are still enigmatic. Transcription regulatory elements, such as rho proteins, play an important role in the termination of transcription and/or the selection of genes in Brucella. Adverse effects of the transcription inhibitors play a key role in the non-successive transcription challenges faced by the pathogens. In the investigation presented here, we computationally predicted the transcription termination factor rho (TtFRho) inhibitors against @entity6 via a structure-based method. In view the unknown nature of its crystal structure, we constructed a robust three-dimensional homology model of TtFRho's structure by comparative modeling with the crystal structure of the @entity2 TtFRho (Protein Data Bank ID: 1PVO) as a template in MODELLER (v 9.10). The modeled structure was optimized by applying a molecular dynamics simulation for 2 ns with the @entity5 ( @entity5 ) 27 force field in NAMD (NAnoscale Molecular Dynamics program; v 2.9) and then evaluated by calculating the stereochemical quality of the protein. The flexible docking for the interaction phenomenon of the template consists of ligand-related inhibitor molecules from the ZINC (ZINC Is Not Commercial) database using a structure-based virtual screening strategy against minimized TtFRho. Docking simulations revealed two inhibitors compounds - ZINC24934545 and ZINC72319544 - that showed high binding affinity among 2,829 drug analogs that bind with key active-site residues; these residues are considered for protein-ligand binding and unbinding pathways via steered molecular dynamics simulations. Arg215 in the model plays an important role in the stability of the protein-ligand complex via a hydrogen bonding interaction by aromatic-   contacts, and the ADMET (absorption, distribution, metabolism, and excretion) analysis of best leads indicate nontoxic in nature with good potential for drug development.

title: Modeling, molecular dynamics, and docking assessment of transcription factor rho: a potential drug target in XXXX .

answer: @entity6


abstract: PURPOSE: To identify all hospitalized @entity0 surviving severe @entity1 ( @entity1 ) in Denmark and to compare these @entity0 to @entity1 @entity0 admitted to highly specialized rehabilitation (HS-rehabilitation). @entity0 AND METHODS: @entity0 surviving severe @entity1 were identified from The Danish National @entity0 Registry and The Danish @entity2 Database. Overall incidence rates of surviving severe @entity1 and incidence rates of admission to HS-rehabilitation after severe @entity1 were estimated and compared. @entity0 -related predictors of no admission to HS-rehabilitation among @entity0 surviving severe @entity1 were identified using multivariable logistic regression. RESULTS: The average incidence rate of surviving severe @entity1 was 2.3 per 100,000 @entity0 years. Incidence rates of HS-rehabilitation were generally stable around 2.0 per 100,000 @entity0 years. Overall, 84% of all @entity0 surviving severe @entity1 were admitted to HS-rehabilitation. Female sex, older age, and non-working status pre-injury were independent predictors of no HS-rehabilitation among @entity0 surviving severe @entity1 . CONCLUSION: The incidence rate of hospitalized @entity0 surviving severe @entity1 was stable in Denmark and the majority of the @entity0 were admitted to HS-rehabilitation. However, potential inequity in access to HS-rehabilitation may still be present despite a health care system based on equal access for all citizens.

title: Surviving severe XXXX in Denmark: incidence and predictors of highly specialized rehabilitation.

answer: @entity1


abstract: UNASSIGNED: Brazil has an aging population, with an associated increase in the prevalence of @entity2 . @entity4 is of particular concern because it leads to an increased risk of @entity5 , with subsequent negative impacts on health in older @entity0 . In recent years, efforts have been made to better understand the epidemiology of @entity4 in Brazil, and to manage both direct and indirect costs to the Brazilian health care system. The reported prevalence of @entity4 among postmenopausal @entity0 in Brazil varies from 15% to 33%, depending on the study methodology and the use of bone densitometry data or self-reporting by @entity0 . A diagnosis of @entity4 can be made on the basis of @entity5 occurring without significant @entity3 or on the basis of low bone mineral density measured by dual energy X-ray absorptiometry. To reduce the risk of @entity4 , all postmenopausal @entity0 should be encouraged to maintain a healthy lifestyle, which includes physical activity and a balanced diet. Smoking and alcohol use should also be addressed. Special attention should be given to interventions to reduce the risk of falls, especially among older @entity0 . Calcium intake should be encouraged, preferably through diet. The decision to recommend calcium supplementation should be made individually because there is concern about a possible increased risk of @entity1 associated with this treatment. Brazilian @entity0 obtain a minimal amount of vitamin D from their diet, and supplementation is warranted in @entity0 with little exposure to solar ultraviolet-B radiation. For @entity0 diagnosed with @entity4 , some form of pharmacologic therapy should be initiated. Compliance with treatment should be monitored, and the treatment period should be individualized for each @entity0 . The Brazilian government provides medication for @entity4 through the public health system free of charge, but without proper epidemiological knowledge, the implementation of public health programs is impaired.

title: The epidemiology and management of XXXX : a viewpoint from Brazil.

answer: @entity4


abstract: BACKGROUND/PURPOSE: The aim of this study was to evaluate the role of consolidation radiotherapy ( @entity3 ) in advanced-stage @entity4 ( @entity4 ) with initial bulky sites after radiological complete remission (CR) or partial response (PR) with positron emission tomography-negative (metabolic CR) following standard chemotherapy (ABVD [Adriamycin, bleomycin, vinblastine, and dacarbazine]) six to eight cycles. @entity0 AND METHODS: Adult @entity0 with @entity4 treated at our institute during the period 2006 to 2012 were retrospectively evaluated. One hundred and ninety-two @entity0 with @entity2 size (>7 cm) who attained radiological CR/PR and metabolic CR were included in the analysis. One hundred and thirteen @entity0 who received radiotherapy ( @entity3 ) as consolidation postchemotherapy ( @entity3 group) were compared to 79 @entity0 who did not receive @entity3 ( @entity3 ). Disease-free (DFS) and @entity5 ( @entity5 ) rates were estimated using the Kaplan-Meier method and were compared according to treatment group by the log-rank tests at P  <=0.05 significance level. RESULTS: The mean age of the cohort was 33 (range: 14 to 81) years. Eighty-four @entity0 received involved-field radiation and 29 @entity0 received involved-site @entity3 . The @entity3 group had worse prognostic factors compared to the @entity3 . Thirteen (12%) relapses occurred in the @entity3 group, and 19 (24%) relapses occurred in the @entity3 . Nine @entity0 (8%) in the @entity3 group died, compared to eleven @entity0 (14%) in the @entity3 . Second @entity1 were seen in only five @entity0 : three @entity0 in the @entity3 group compared to two @entity0 in the @entity3 . At 5 years, overall DFS was 79%  9% and @entity5 was 85%  9%. There was significant statistical difference between the @entity3 group and the @entity3 regarding 5-year DFS: 86%  7% and 74%  9%, respectively (P  <=0.02). However, the 5-year @entity5 was 90%  5% for the @entity3 group and 83%  8% for the @entity3 , with no statistical difference (P  <=0.3). CONCLUSION: The results of our study suggest that consolidation @entity3 in @entity0 with @entity4 with @entity2 who had postchemotherapy radiologic CR or PR with metabolic CR improved the DFS.

title: The benefit of consolidation radiotherapy to initial disease bulk in @entity0 with advanced XXXX who achieved complete remission after standard chemotherapy.

answer: @entity4


abstract: BACKGROUND/PURPOSE: The aim of this study was to evaluate the role of consolidation radiotherapy ( @entity3 ) in advanced-stage @entity4 ( @entity4 ) with initial bulky sites after radiological complete remission (CR) or partial response (PR) with positron emission tomography-negative (metabolic CR) following standard chemotherapy (ABVD [Adriamycin, bleomycin, vinblastine, and dacarbazine]) six to eight cycles. @entity0 AND METHODS: Adult @entity0 with @entity4 treated at our institute during the period 2006 to 2012 were retrospectively evaluated. One hundred and ninety-two @entity0 with @entity2 size (>7 cm) who attained radiological CR/PR and metabolic CR were included in the analysis. One hundred and thirteen @entity0 who received radiotherapy ( @entity3 ) as consolidation postchemotherapy ( @entity3 group) were compared to 79 @entity0 who did not receive @entity3 ( @entity3 ). Disease-free (DFS) and @entity5 ( @entity5 ) rates were estimated using the Kaplan-Meier method and were compared according to treatment group by the log-rank tests at P  <=0.05 significance level. RESULTS: The mean age of the cohort was 33 (range: 14 to 81) years. Eighty-four @entity0 received involved-field radiation and 29 @entity0 received involved-site @entity3 . The @entity3 group had worse prognostic factors compared to the @entity3 . Thirteen (12%) relapses occurred in the @entity3 group, and 19 (24%) relapses occurred in the @entity3 . Nine @entity0 (8%) in the @entity3 group died, compared to eleven @entity0 (14%) in the @entity3 . Second @entity1 were seen in only five @entity0 : three @entity0 in the @entity3 group compared to two @entity0 in the @entity3 . At 5 years, overall DFS was 79%  9% and @entity5 was 85%  9%. There was significant statistical difference between the @entity3 group and the @entity3 regarding 5-year DFS: 86%  7% and 74%  9%, respectively (P  <=0.02). However, the 5-year @entity5 was 90%  5% for the @entity3 group and 83%  8% for the @entity3 , with no statistical difference (P  <=0.3). CONCLUSION: The results of our study suggest that consolidation @entity3 in @entity0 with @entity4 with @entity2 who had postchemotherapy radiologic CR or PR with metabolic CR improved the DFS.

title: The benefit of consolidation radiotherapy to initial disease bulk in XXXX with advanced @entity4 who achieved complete remission after standard chemotherapy.

answer: @entity0


abstract: BACKGROUND AND OBJECTIVES: Enteropathogenic @entity1 (EPEC) divided into two groups typical and atypical (aspect). The main virulence genes are located in a pathogenicity island called LEE (Locus of Enterocyte Effacement). LEE frequently inserted in tRNA genes of selC, pheU and @entity2 in the bacterial chromosome. tEPEC and aEPEC strains have some differences in their pathogenicity. The purpose of this was to investigate the possible differences between tEPEC and aEPEC strains according to the virulence genes encoding by LEE and their relation to insertion sites. MATERIALS AND METHODS: In this study 130 @entity1 isolates confirmed by biochemical analysis from diarrheal @entity0 , were evaluated for EPEC pathotype by PCR. All EPEC strains tested for presence of some LEE encoded virulence genes and sites of LEE insertion by PCR method. RESULTS: Among 50 strains of EPEC 28 (56%) and 22 (44%) were typical and atypical strains respectively. 19 strains (30%) showed insertion in selC, 7 (14%) in pheU, 4 (8%) in @entity2 , 8 (16%) in pheU and @entity2 , 1 (2%) in selC and pheU, 6 (12%) in @entity2 , pheU and selC and 5 (10%) had no insertion in these sites. Moreover, @entity3 (n = 8, 16%), espB (n = 16, 32%), espD (n = 18, 36%), espF (n = 8, 16%), espG (n = 13, 26%), espH (n = 12, 24%), map (n = 11, 32%) and tir (n = 4, 8%) were present among the strains. CONCLUSION: Results showed that most of the virulence genes are present in tEPEC isolates. However, aEPEC isolates may acquire other virulence factors. The majority of tEPEC strains showed insertion at selC and aEPEC strains in @entity2 and pheU.

title: Genetic evaluation of Locus of enterocyte effacement pathogenicity island (LEE) in Enteropathogenic XXXX isolates (EPEC).

answer: @entity1


abstract: PURPOSE: The Utah Improving Care through Connectivity and Collaboration (IC3) Beacon community (2010-2013) was spearheaded by HealthInsight, a nonprofit, community-based organization. One of the main objectives of IC(3) was to improve health care provided to @entity0 with @entity1 in three Utah counties, collaborating with 21 independent smaller clinics and two large health care enterprises. This paper will focus on the use of @entity2 ( @entity2 ) and practice facilitation to develop and implement new care processes to improve clinic workflow and ultimately improve @entity0 ' @entity1 outcomes at 21 participating smaller, independent clinics. INNOVATION: Early in the project, we learned that most of the 21 clinics did not have the resources needed to successfully implement quality improvement (QI) initiatives. IC(3) helped clinics effectively use data generated from their electronic health records (EHRs) to design and implement interventions to improve @entity0 ' @entity1 outcomes. This close coupling of @entity2 , expert practice facilitation, and Learning Collaboratives was found to be especially valuable in clinics with limited resources. FINDINGS: Through this process we learned that (1) an extensive readiness assessment improved clinic retention, (2) clinic champions were important for a successful collaboration, and (3) current EHR systems have limited functionality to assist in QI initiatives. In general, smaller, independent clinics lack knowledge and experience with QI and have limited @entity2 experience to improve @entity0 care using electronic clinical data. Additionally, future projects like IC(3) Beacon will be instrumental in changing clinic culture so that QI is integrated into routine workflow. CONCLUSION AND DISCUSSION: Our efforts led to significant changes in how practice staff optimized their EHRs to manage and improve @entity1 care, while establishing the framework for sustainability. Some of the IC(3) Beacon practices are currently smoothly transitioning to new models of care such as @entity0 -Centered Medical Homes. Thus, IC(3) Beacon has been instrumental in creating a strong community partnership among various organizations to meet the shared vision of better health and lower costs, and the experience over the last few years has helped the community prepare for the changing health care landscape.

title: The utah beacon experience: integrating quality improvement, @entity2 , and practice facilitation to improve XXXX outcomes in small health care facilities.

answer: @entity1


abstract: PURPOSE: The Utah Improving Care through Connectivity and Collaboration (IC3) Beacon community (2010-2013) was spearheaded by HealthInsight, a nonprofit, community-based organization. One of the main objectives of IC(3) was to improve health care provided to @entity0 with @entity1 in three Utah counties, collaborating with 21 independent smaller clinics and two large health care enterprises. This paper will focus on the use of @entity2 ( @entity2 ) and practice facilitation to develop and implement new care processes to improve clinic workflow and ultimately improve @entity0 ' @entity1 outcomes at 21 participating smaller, independent clinics. INNOVATION: Early in the project, we learned that most of the 21 clinics did not have the resources needed to successfully implement quality improvement (QI) initiatives. IC(3) helped clinics effectively use data generated from their electronic health records (EHRs) to design and implement interventions to improve @entity0 ' @entity1 outcomes. This close coupling of @entity2 , expert practice facilitation, and Learning Collaboratives was found to be especially valuable in clinics with limited resources. FINDINGS: Through this process we learned that (1) an extensive readiness assessment improved clinic retention, (2) clinic champions were important for a successful collaboration, and (3) current EHR systems have limited functionality to assist in QI initiatives. In general, smaller, independent clinics lack knowledge and experience with QI and have limited @entity2 experience to improve @entity0 care using electronic clinical data. Additionally, future projects like IC(3) Beacon will be instrumental in changing clinic culture so that QI is integrated into routine workflow. CONCLUSION AND DISCUSSION: Our efforts led to significant changes in how practice staff optimized their EHRs to manage and improve @entity1 care, while establishing the framework for sustainability. Some of the IC(3) Beacon practices are currently smoothly transitioning to new models of care such as @entity0 -Centered Medical Homes. Thus, IC(3) Beacon has been instrumental in creating a strong community partnership among various organizations to meet the shared vision of better health and lower costs, and the experience over the last few years has helped the community prepare for the changing health care landscape.

title: The utah beacon experience: integrating quality improvement, XXXX , and practice facilitation to improve @entity1 outcomes in small health care facilities.

answer: @entity2


abstract: INTRODUCTION: The Southeastern (SE) Minnesota @entity5 organized all the health care providers, county public health organizations, and school districts in the deployment and integration of health information exchange (HIE) and targeted health communication around childhood @entity3 and @entity1 . The community cooperated to establish a clinical data repository for all residents in the 11-county region. Through this community of practice approach that involved traditional and nontraditional providers, the SE Minnesota @entity5 was able to realize unique applications of this technology. This manuscript overviews the associated organization and infrastructure of this community collaboration. BACKGROUND: The Office of the National Coordinator for Health Information Technology (ONC), as part of the American Recovery and Reinvestment Act of 2009 (ARRA) stimulus, established 17 projects throughout the United States targeting the introduction and meaningful use of @entity2 ( @entity2 ). These 17 communities were intended to serve as an example of what could be accomplished. The SE Minnesota @entity5 is one of these communities. METHODS: The community ultimately opted for peer-to-peer HIE, using Nationwide Health Information Network (NwHIN) Connect software. The clinical data repository was established using the infrastructure developed by the Regenstrief Institute, which operated as a trusted third party. As an extension to HIE, the consortium of county public health departments created a @entity0 data portal for use by school nurses and parents. Childhood @entity3 was addressed by creating, exchanging, and maintaining an " @entity3 action plan" for each affected @entity0 , shared throughout the community, including through the @entity0 portal. @entity1 management introduced @entity0 treatment decision tools and @entity0 quality of life measures, facilitating care. @entity4 vaccination was enhanced by large-scale community reporting in partnership with the state vaccination registry. The methodology and principles for arriving at these solutions included community engagement, sustainability, scalability, standards, and best practices that fit a variety of organizations-from large, robust providers to small organizations. FINDINGS: The SE Minnesota @entity5 demonstrated that all providers for a geographically defined population can cooperate in the development and shared governance of a low-cost, sustainable HIE, and the operation of a community-managed clinical data repository. Furthermore, these infrastructures can be leveraged to collaboratively improve the care of @entity0 , as demonstrated for childhood @entity3 and adult @entity1 . CONCLUSION: The shared governance of @entity2 by a community can palpably change the scope and success of collaborations targeted to improve @entity0 and community health care.

title: The Southeastern Minnesota XXXX Project for Community-driven Health Information Technology: Origins, Achievements, and Legacy.

answer: @entity5


abstract: A dominant mutation in the @entity0 , @entity3 ( @entity3 ), induces @entity2 in heterozygotes. Typical expression includes axial shortening of the radius, tibia and talus (' @entity3 '), with supernumerary metacarpals, metatarsals, and digits ('polydactyly'). Pathogenesis was investigated during developmental stages 16 through 22 (11th through 15th days of gestation). Full expression was apparent during stage 20 when the limb pattern was comprised of pre-cartilaginous anlagen. Formation of a pre-axial protrusion on the autopod during stage 17 or 18 was the earliest gross abnormality, and foreshadowed the development of @entity4 . Microscopically, there was an alteration in the pattern of @entity1 ( @entity1 ) programmed to occur within the zeugopod and autopod. The 'opaque patch' (mesodermal necrotic zone normally occurring between tibial and fibular anlagen) was overextended pre-axially causing resorption of the tibial precartilage. Additionally, @entity1 normally occurring within the basal cell layer of the apical ectodermal ridge (AER) and the 'foyer primaire pr  axial' was not expressed in the mutant autopod. This occurred in association with outgrowth of the protrusion. The pre-axial portion of the AER remained in an abnormally thickened, viable, proliferative state, and did not undergo scheduled degression. This may have been the basis for prolonged induction of pre-axial outgrowth. Paucity of mesenchymal cell filopodial processes extended along the basal lamina, as well as a rarefaction of the filamentous material normally associated with the mesodermal face of the basal lamina, was detected at the pre-axial AER-mesenchymal interface on stage 18. A potential involvement of epithelial-mesenchymal interactions in the induction of epithelial @entity1 is discussed.

title: The role of morphogenetic cell death during abnormal limb-bud outgrowth in @entity0 heterozygous for the dominant mutation XXXX ( @entity3 ).

answer: @entity3


abstract: A dominant mutation in the @entity0 , @entity3 ( @entity3 ), induces @entity2 in heterozygotes. Typical expression includes axial shortening of the radius, tibia and talus (' @entity3 '), with supernumerary metacarpals, metatarsals, and digits ('polydactyly'). Pathogenesis was investigated during developmental stages 16 through 22 (11th through 15th days of gestation). Full expression was apparent during stage 20 when the limb pattern was comprised of pre-cartilaginous anlagen. Formation of a pre-axial protrusion on the autopod during stage 17 or 18 was the earliest gross abnormality, and foreshadowed the development of @entity4 . Microscopically, there was an alteration in the pattern of @entity1 ( @entity1 ) programmed to occur within the zeugopod and autopod. The 'opaque patch' (mesodermal necrotic zone normally occurring between tibial and fibular anlagen) was overextended pre-axially causing resorption of the tibial precartilage. Additionally, @entity1 normally occurring within the basal cell layer of the apical ectodermal ridge (AER) and the 'foyer primaire pr  axial' was not expressed in the mutant autopod. This occurred in association with outgrowth of the protrusion. The pre-axial portion of the AER remained in an abnormally thickened, viable, proliferative state, and did not undergo scheduled degression. This may have been the basis for prolonged induction of pre-axial outgrowth. Paucity of mesenchymal cell filopodial processes extended along the basal lamina, as well as a rarefaction of the filamentous material normally associated with the mesodermal face of the basal lamina, was detected at the pre-axial AER-mesenchymal interface on stage 18. A potential involvement of epithelial-mesenchymal interactions in the induction of epithelial @entity1 is discussed.

title: The role of morphogenetic cell death during abnormal limb-bud outgrowth in @entity0 heterozygous for the dominant mutation @entity3 ( XXXX ).

answer: @entity3


abstract: A dominant mutation in the @entity0 , @entity3 ( @entity3 ), induces @entity2 in heterozygotes. Typical expression includes axial shortening of the radius, tibia and talus (' @entity3 '), with supernumerary metacarpals, metatarsals, and digits ('polydactyly'). Pathogenesis was investigated during developmental stages 16 through 22 (11th through 15th days of gestation). Full expression was apparent during stage 20 when the limb pattern was comprised of pre-cartilaginous anlagen. Formation of a pre-axial protrusion on the autopod during stage 17 or 18 was the earliest gross abnormality, and foreshadowed the development of @entity4 . Microscopically, there was an alteration in the pattern of @entity1 ( @entity1 ) programmed to occur within the zeugopod and autopod. The 'opaque patch' (mesodermal necrotic zone normally occurring between tibial and fibular anlagen) was overextended pre-axially causing resorption of the tibial precartilage. Additionally, @entity1 normally occurring within the basal cell layer of the apical ectodermal ridge (AER) and the 'foyer primaire pr  axial' was not expressed in the mutant autopod. This occurred in association with outgrowth of the protrusion. The pre-axial portion of the AER remained in an abnormally thickened, viable, proliferative state, and did not undergo scheduled degression. This may have been the basis for prolonged induction of pre-axial outgrowth. Paucity of mesenchymal cell filopodial processes extended along the basal lamina, as well as a rarefaction of the filamentous material normally associated with the mesodermal face of the basal lamina, was detected at the pre-axial AER-mesenchymal interface on stage 18. A potential involvement of epithelial-mesenchymal interactions in the induction of epithelial @entity1 is discussed.

title: The role of morphogenetic cell death during abnormal limb-bud outgrowth in XXXX heterozygous for the dominant mutation @entity3 ( @entity3 ).

answer: @entity0


abstract: OBJECTIVE: To determine factors and outcomes associated with ultra-early surgery for poor-grade @entity4 ( @entity4 ). DESIGN: A multicentre retrospective analysis, observational study. SETTING: High-volume teaching hospitals (more than 150 @entity4 cases per year). @entity0 : 118 @entity0 with World Federation of Neurosurgical Societies (WFNS) grades IV and V underwent surgical treatment. Ultra-early surgery was defined as surgery performed within 24   h of @entity4 , and delayed surgery as surgery performed after 24   h. Outcome was assessed by modified Rankin Scale (mRS). The mean time of follow-up was 12.5  3.4   months (range 6-28   months). RESULTS: 47 (40%) @entity0 underwent ultra-early surgery, and 71 (60%) @entity0 underwent delayed surgery. @entity0 with WFNS grade V (p=0.011) and @entity1 (p=0.004) more often underwent ultra-early surgery. @entity2 were similar in ultra-early and delayed surgery groups. Adjusted multivariate analysis showed the outcomes were similar between the two groups. Multivariate analysis of predictors of poor outcome, ultraearly surgery was not an independent predictor of poor outcome, while advanced age, postresuscitation WFNS V grade, @entity5 , @entity3 were associated with poor outcome. CONCLUSIONS: Although @entity0 with WFNS grade V and @entity1 more often undergo ultra-early surgery, postoperative complications and outcomes in selected @entity0 were similar in the two groups. @entity0 of younger age, WFNS grade IV, absence of @entity5 , @entity3 are more likely to have a good outcome. Ultra-early surgery could improve outcomes in carefully selected @entity0 with poor-grade @entity4 .

title: Factors and outcomes associated with ultra-early surgery for poor-grade XXXX : a multicentre retrospective analysis.

answer: @entity4


abstract: UNASSIGNED: @entity0 on dialysis are 20 times more likely to have a @entity2 compared with the general population. We considered whether inherited factors associate with @entity2 among @entity0 on dialysis. From a sample of 647,457 @entity0 on chronic dialysis, we identified 5117 pairs of @entity0 who came from the same family. These @entity0 were each matched to a control subject from the same population. McNemar's tests were used to compare the risk of @entity2 between the familial related and unrelated pairs. Genetically related family members who did not cohabitate had an odds ratio of 1.88 (95% confidence interval [95% CI], 1.25 to 2.84) for @entity2 compared with their phenotypically matched unrelated controls. Genetically related family members who lived together in the same environment had an odds ratio of 1.66 (95% CI, 1.20 to 2.28). Spouses, who are genetically unrelated but live together in the same environment, had an odds ratio of 0.95 (95% CI, 0.60 to 1.59) for @entity2 . The risk of @entity2 in @entity0 on dialysis may be attributable to inherited factors. Additional studies are needed to identify such candidate genes that modify cardiovascular risk in @entity1 .

title: Heritability of Risk for Sudden Cardiac Arrest in XXXX .

answer: @entity1


abstract: UNASSIGNED: The phosphatases @entity6 and @entity9 have been proposed to act as @entity2 suppressors by antagonizing PI3K-AKT signaling and are frequently dysregulated in @entity0 @entity2 . Although @entity6 has been extensively studied, little is known about the underlying mechanisms by which @entity9 exerts its @entity2 -suppressive function and its role in tumorigenesis in vivo. Here, we show that a partial or complete loss of @entity10 morphs benign thyroid @entity5 in @entity7 heterozygous @entity3 into lethal and metastatic @entity4 ( @entity4 ). Importantly, analyses of @entity0 @entity4 cell lines and specimens reveal @entity9 downregulation in @entity4 . Mechanistically, we find that @entity9 , but not @entity6 , is enriched in the early endosomes of @entity4 cells, where it selectively inhibits @entity8 activation and in turn @entity2 proliferation and anchorage-independent growth. We therefore identify @entity9 as a novel @entity2 suppressor in @entity4 oncogenesis and @entity1 through localized regulation of the PI3K-AKT pathway at the endosomes. SIGNIFICANCE: Although both @entity6 and @entity9 can inhibit PI3K-AKT signaling through their lipid phosphatase activities, here we demonstrate lack of an epistatic relationship between the two @entity2 suppressors. Instead, the qualitative regulation of PI3K- @entity8 signaling by @entity9 provides a mechanism for their cooperation in suppressing thyroid tumorigenesis and @entity1 . @entity2 Discov; 5(7); 1-12.   2015 AACR.See related commentary by Vo and Fruman, p. 697.See related article by Kofuji and colleagues, p. 730.

title: In Vivo Role of XXXX in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.

answer: @entity9


abstract: AIMS: Irrigated multi-electrode ablation (IMEA) is a novel tool to perform @entity1 ( @entity1 ). The aim was to compare IMEA with point-by-point radiofrequency (RF) ablation in @entity0 with persistent @entity2 ( @entity2 ) undergoing @entity1 . METHODS AND RESULTS: Forty-nine @entity0 (age 60    9 years, 82% male) were studied. In 24 @entity0 , the IMEA catheter was used in conjunction with an electroanatomic mapping system. Twenty-five @entity0 undergoing RF point-by-point ablation (RF- @entity1 ) served as a control group. Validation of @entity1 based on the IMEA catheter was performed using a standard circular mapping catheter. Ninety-two of 94 pulmonary veins (PVs) (98%) were isolated using IMEA alone. Procedure time was 125    23 min in the IMEA group and 127    31 min in the RF- @entity1 group (P = 0.79). Fluoroscopy time was 12.2 (11-16.1) min with IMEA compared with 5.2 (4.1-9.3) min in the RF- @entity1 group (P < 0.001). Net ablation time was 11.8 (10.2-15.4) min in the IMEA group compared with 33.6 (30.3-40.1) min in the RF- @entity1 group (P < 0.001). Of 94 PVs presumed to be isolated after IMEA ablation, validation using a standard circular mapping catheter showed persistent PV potentials in 33 PVs (35%), requiring additional IMEA ablation. At 12 months, 16 of 24 @entity0 (67%) in the IMEA group compared with 17 of 25 @entity0 (68%) in RF- @entity1 group were free from @entity2 (P > 0.99). CONCLUSION: With similar total procedure duration, IMEA- @entity1 was associated with shorter net ablation time and longer fluoroscopy time. Irrigated multi-electrode ablation recordings were not sufficient to confirm isolation in 35% of PVs. Single-procedure efficacy after 12 months was similar between the two groups.

title: One-year follow-up after irrigated multi-electrode radiofrequency ablation of persistent XXXX .

answer: @entity2


abstract: The following conclusions can be drawn from examination results: 1. The degree to which the functional condition of the cardiovascular system varies depends on the caloric content of the diet. 2. In elderly @entity0 functional changes of the cardiovascular system can be observed to take place in two stages (1st stage about 1 hour, 2nd stage from 3rd to 5th hour after meals). 3. A high-caloric diet can be expected to provoke an inadequate cardiovascular response in elderly @entity1 . 4. The impact of fat in the diet on cardiovascular function depends on the subject's age and the kind of fat consumed. Saturated fats have a more adverse effect that unsaturated ones. 5. That a high concentration of blood sugar influences metabolic processes in the myocardium ( @entity2 metabolism, @entity3 balance, membrane effects) seems to be an established fact. 6. @entity5 appears to have a considerable direct effect on the myocardium and on variations of the sympathico-adrenal and vago-insulinary systems. 7. The second postprandial stage of functional changes in the cardiovascular system, based on a relative hypoglycaemia, is probably induced by a sudden release of @entity4 .

title: [The influence of diet habits and diet compose upon the heart and circulation system of elderly XXXX (author's transl)].

answer: @entity0


abstract: Speckle tracking echocardiography (STE) has been applied to the evaluation of @entity1 . However, there were few studies on alteration of global and regional STE parameters in the process of @entity4 and @entity2 . In this study, STE was applied to evaluate the global and regional cardiac function under @entity2 and @entity3 in the @entity0 model of pressure overload. Adult @entity0 were subjected to mild or severe aortic banding with a 25 Gauge (G) or 27 G needle. After surgery, STE and conventional echocardiography were used in the sham group (n=10), mild @entity5 ( @entity5 ) group (n=14) and severe @entity5 group (n=10) for 8 weeks. The results showed that the @entity0 subjected to severe @entity5 showed a significant change in fractional shortening (FS), left ventricular (LV) mass, and left ventricular end diastolic diameter (LVEDD) (P<0.05 for each). Meanwhile, there were no significant differences in FS and LVEDD between the sham group and mild @entity5 group during the experimental procedures (P>0.05 for both). STE analysis revealed that @entity6 ( @entity6 ) was significantly decreased in the severe @entity5 group as compared with the sham and mild @entity5 groups (P<0.05 for both) from the postoperative week 1. @entity6 in the mild @entity5 group was reduced as compared to the sham group (P<0.05). @entity6 ( @entity6 ) and circumferential strain (CS) were significantly decreased in the severe @entity5 group as compared to the sham group and the mild @entity5 group (P<0.05 for both) from the postoperative week 1 (P<0.05 for both). Compared to the sham group, CS in the mild @entity5 group maintained unchanged during the test period, and @entity6 was reduced only on the postoperative week 6 (P<0.05). Finally, regional contraction dysfunction was analyzed in both @entity3 in longitudinal and radial directions. It was found that @entity6 was largest in the apex region and @entity6 was smallest in the apex region in the healthy and @entity3 . It was also found that compared to the sham group, only base @entity6 in the mild @entity5 group was decreased. Each of regional strain in the severe @entity5 group was uniformly depressed in radial and longitudinal directions. It is concluded that STE has provided a non-invasive and highly feasible way to explore the global and regional contraction dysfunction in @entity3 and @entity2 myocardium in the @entity0 model of pressure overload.

title: Speckle tracking echocardiography assessment of global and regional contraction dysfunction in the XXXX model of pressure overload.

answer: @entity0


abstract: KEY MESSAGE: The implementation of @entity1 in breeding programs can be recommended for hybrid and line breeding in @entity0 . High prediction accuracies from @entity1 ( @entity1 ) were reported for grain yield in @entity0 asking for the elaboration of efficient breeding strategies applying @entity1 . Our objectives were therefore, (1) to optimize the number of lines, locations and testers in different multi-stage breeding strategies with and without @entity1 , (2) to elaborate the most efficient breeding strategy based on the selection gain and its standard deviation, and (3) to investigate the potential of @entity1 to improve the relative efficiency of hybrid versus line breeding in @entity0 . We used the open source software package "selectiongain" to optimize the allocation of resources in different breeding strategies by predicting the expected selection gain for a fixed budget. Classical two-stage phenotypic selection was compared with three @entity1 breeding strategies for line and hybrid breeding in @entity0 . The ranking of the alternative breeding strategies varied largely in dependence of the @entity1 prediction accuracy. Fast-track breeding strategies based solely on @entity1 were only advantageous for high @entity1 prediction accuracies that is >0.50 and >0.65 for hybrid and line breeding, respectively. However, a @entity1 prediction accuracy across breeding cycles of 0.3 or even less must be assumed as realistic for grain yield in @entity0 . For this low @entity1 prediction accuracy, the use of @entity1 is advantageous for line but especially for hybrid breeding in @entity0 . Furthermore, the use of @entity1 in hybrid @entity0 breeding increased the relative efficiency of hybrid versus line breeding and, thus, might be an important pillar for the establishment of hybrid @entity0 .

title: Genomic selection in XXXX : optimum allocation of test resources and comparison of breeding strategies for line and hybrid breeding.

answer: @entity0


abstract: BACKGROUND: The extended disability severity scale (EDSS) is clinically useful in assessing disability in @entity1 ( @entity1 ) @entity0 . It is also being used in studies to determine how genes and environment influence disability. However, since it has a complex relationship with functional scores and mobility and is strongly determined by disease duration its use can be limiting. OBJECTIVE: Study associations of variables with progression described by time from disease onset until EDSS. METHODS: We used a variable based on below/above median time from @entity1 onset to reach a single EDSS value to define slow or fast progression. We compared @entity0 categorization using this variable and MSSS, and in 533 @entity0 (EDSS 1-8) and 242 of these @entity0 with @entity3 -4, studied associations with skin type, gender, ultraviolet radiation and @entity4 @entity5 . RESULTS: Classifying @entity0 into quartiles of slow/fast progression showed mean MSSS increased with faster progression (p<0.001). For EDSS 1-8: MSSS, late onset age and childhood sunburning were associated with fast and @entity4 CG/GG(294) with slow progression. Combinations of skin type (1/2 or 3/4) with childhood weekend exposure (< or >= median) or sunburning (yes/no) were not associated with progression. However, in @entity0 with @entity3 -4, relative to other combinations, those with no sunburning history and types 1/2 demonstrated slow progression (odds ratio=0.15, 95% CI=0.04, 0.57). CONCLUSION: This method, though a pilot, allows study of associations of variables with EDSS. It is based on local @entity0 and could substitute for MSSS. In @entity0 with @entity3 -4 but not 1-8, skin type 1/2 with no history of childhood sunburning was associated with slow progression. This is compatible with the view that disability develops through a first stage dependent on @entity2 .

title: Progression of disability in XXXX : A study of factors influencing median time to reach an EDSS value.

answer: @entity1


abstract: @entity1 ( @entity1 ) and @entity2 ( @entity2 ) are rare antibody mediated @entity3 (NMJ) respectively. Both diseases are predominantly mediated by IgG1 antibodies that activate complement. There have been increasing reports of @entity0 who develop both disorders. Given the rarity of both diseases it would seem that these occurrences are not purely coincidental. There is heterogeneity between the cases described in the literature but common trends are observed in @entity0 who develop both disorders. Most @entity0 described are female. Typically the @entity2 precedes the @entity1 and the majority of @entity0 have undergone thymectomy. Generally, the symptoms of @entity2 are mild but the @entity1 tends to follow a more aggressive clinical course. The pathogenesis of @entity1 in combination with @entity2 is unknown, but thymectomy has been implicated in a subset of @entity0 . We present the case of a female @entity0 who developed @entity1 on a background of sero-positive @entity2 and discuss the relevant literature.

title: XXXX and @entity1 opica: A causal link.

answer: @entity2