abstract: This study analyzed neuronal encoding and response thresholds to thermal stimuli at the ventro-basal (V.B.) thalamus level during a hyperalgesic @entity1 induced by intra-plantar injection of carrageenin in the @entity2 . The threshold and the encoding capacity of the cells were studied during two phases of the inflammatory process, namely the "acute" phase (the first two hours following the injection), and "sub-acute" phase 24 h after). In this second phase the @entity3 was verified using a behavioral nociceptive test, just prior to the recording session. Only VB neurones with a receptive field that included the injected paw were considered. In the acute phase, neurones exclusively driven by noxious stimuli were studied before and during the first two hours following the induction of the @entity0 . In the sub-acute phase two groups of neurones which, on the basis of our previous studies, were presumably involved in the transmission of messages giving rise to the @entity3 could be separated: a group of neurones which were driven by intense mechanical stimuli and another group driven by moderate mechanical stimulation applied to the inflamed joints and/or the surrounding cutaneous areas. In the "acute" phase there was a dramatic lowering (by about 4 degrees C) of the response threshold of the neurones when the thermal stimulus was applied to the injected paw, although their threshold to the mechanical stimulus was still high. A linear encoding of the bath temperature used as a stimulus was observed for both the injected and the non-injected paws. For a few neurones, a leftward shift of the stimulus-response curve was found for the inflamed limb. In the "sub-acute" phase, neurones with high thresholds to the mechanical indentations still exhibited a low response threshold to the thermal stimulation, not only from the injected but also from the non-injected paw. The other group of neurones responded with relatively low thresholds to the both stimulus modalities. By contrast to the acute phase, the two groups of neurones exhibited only a weak ability to encode the stimulus intensity especially when the stimulus was applied to the inflamed paw. Both peripheral and central mechanisms are likely to be involved in the modifications of response threshold and encoding capacity at the VB thalamus level seen in these conditions of hyperalgesic @entity1 . The differential time course of the responses to a liminal or to a supra-liminal temperature during the @entity1 , are discussed in reference to some of the mismatches occurring in clinical situations of @entity3 .

title: Neuronal response thresholds to and encoding of thermal stimuli during carrageenin- XXXX in the ventro-basal thalamus of the @entity2 .

answer: @entity1


abstract: This study analyzed neuronal encoding and response thresholds to thermal stimuli at the ventro-basal (V.B.) thalamus level during a hyperalgesic @entity1 induced by intra-plantar injection of carrageenin in the @entity2 . The threshold and the encoding capacity of the cells were studied during two phases of the inflammatory process, namely the "acute" phase (the first two hours following the injection), and "sub-acute" phase 24 h after). In this second phase the @entity3 was verified using a behavioral nociceptive test, just prior to the recording session. Only VB neurones with a receptive field that included the injected paw were considered. In the acute phase, neurones exclusively driven by noxious stimuli were studied before and during the first two hours following the induction of the @entity0 . In the sub-acute phase two groups of neurones which, on the basis of our previous studies, were presumably involved in the transmission of messages giving rise to the @entity3 could be separated: a group of neurones which were driven by intense mechanical stimuli and another group driven by moderate mechanical stimulation applied to the inflamed joints and/or the surrounding cutaneous areas. In the "acute" phase there was a dramatic lowering (by about 4 degrees C) of the response threshold of the neurones when the thermal stimulus was applied to the injected paw, although their threshold to the mechanical stimulus was still high. A linear encoding of the bath temperature used as a stimulus was observed for both the injected and the non-injected paws. For a few neurones, a leftward shift of the stimulus-response curve was found for the inflamed limb. In the "sub-acute" phase, neurones with high thresholds to the mechanical indentations still exhibited a low response threshold to the thermal stimulation, not only from the injected but also from the non-injected paw. The other group of neurones responded with relatively low thresholds to the both stimulus modalities. By contrast to the acute phase, the two groups of neurones exhibited only a weak ability to encode the stimulus intensity especially when the stimulus was applied to the inflamed paw. Both peripheral and central mechanisms are likely to be involved in the modifications of response threshold and encoding capacity at the VB thalamus level seen in these conditions of hyperalgesic @entity1 . The differential time course of the responses to a liminal or to a supra-liminal temperature during the @entity1 , are discussed in reference to some of the mismatches occurring in clinical situations of @entity3 .

title: Neuronal response thresholds to and encoding of thermal stimuli during carrageenin- @entity1 in the ventro-basal thalamus of the XXXX .

answer: @entity2


abstract: OBJECTIVE: To evaluate the diagnostic value of bronchial lavage @entity1 promoter methylation and @entity0 . MATERIALS AND METHODS: The databases of PubMed, Medline, China National Knowledge Infrastructure, and Wanfang were electronically searched by two reviewers to find the suitable studies related to the association between @entity1 Apromoter methylation and @entity0 . The @entity1 Apromoter methylation rate was extracted from each included individual study. The diagnostic sensitivity, specificity, and area under the receiver operating characteristic ROC curve of bronchial lavage @entity1 Aas a biomarker for diagnosis of @entity0 were pooled by stata11.0 software (Stata Corporation, College Station, TX, USA). RESULTS: At last, 10 publications were included in this meta-analysis. Of the included 10 studies, five are published in English with relatively high quality and other five papers published in Chinese have relatively low quality. The pooled sensitivity and specificity of bronchial lavage @entity1 Apromoter methylation for @entity0 diagnosis were 0.61 (95% confidence interval [CI]: 0.57-0.65) and 0.81 (95% CI: 0.78-0.85), respectively, with random effect model. The ROC curve were calculated and drawn according to Bayes' theorem by stata11.0 software. The systematic area under the ROC was 0.72 (95% CI: 0.68-0.76), which indicated that the diagnostic value of bronchial lavage @entity1 Apromoter methylation for @entity0 was relatively high. Moreover, no significant publication bias was existed in this meta-analysis (t = 0.69, P > 0.05). CONCLUSION: Bronchial lavage @entity1 promoter methylation can be a potential biomarker for diagnosis of @entity0 .

title: Bronchial lavage P(16INK4A)gene promoter methylation and XXXX diagnosis: A meta-analysis.

answer: @entity0


abstract: PURPOSE: We studied heart-rate (HR) changes at the transition from the preictal to the ictal state in @entity0 with @entity6 to gain some insight into the mechanisms involved in the neuronal regulation of cardiovascular function. METHODS: We assessed ECG changes during 145 @entity2 recorded with scalp EEG in 58 @entity0 who underwent video-EEG monitoring. Consecutive RR intervals were analyzed with a newly developed mathematical method for a total of 90 s. RESULTS: Ictal-onset @entity3 occurred in 86.9% of all @entity2 , whereas @entity4 was documented only in 1.4%. The incidence as well as the amount of ictal HR increase was significantly more pronounced in @entity0 with mesial @entity5 ( @entity5 ) as compared with those with non-lesional @entity5 or @entity1 . Moreover, right hemispheric @entity2 were associated with ictal-onset @entity3 . On average, ictal HR increase preceded EEG @entity2 onset by 13.7 s in @entity5 @entity0 and 8.2 s in @entity0 with @entity1 . This difference was significant. Ictal HR changes could be classified according to their temporal evolution into two different patterns. These two patterns differed significantly between the temporal lobe and the @entity1 @entity0 group. CONCLUSIONS: @entity1 directly influence areas of the central autonomic network, thus regulating HR and rhythm. Such changes occur before ictal discharges appear on surface electrodes. Our newly developed method may be of potential use for clinical applications such as @entity2 systems. Moreover, our method might help to clarify further the basic mechanisms of interactions between heart and brain.

title: Electrocardiographic changes at the onset of XXXX .

answer: @entity1


abstract: BACKGROUND: @entity10 ( @entity10 ) is a @entity4 that is characterized by abnormal adipose tissue growth mainly at the neck, abdominal wall, back, shoulder girdle, and arms. A suggested mechanism for accumulation of adipose tissue is a defect in the lipolytic pathway of fat cell. OBJECTIVE: To evaluate the clinical, morphologic, and biochemical findings in Korean @entity0 . METHOD: A total of 32 @entity0 with @entity10 were evaluated retrospectively. Ten @entity0 were seen at our hospital. The remaining 22 @entity0 from literature were reviewed. Biochemical analyses and neurologic studies were performed. RESULTS: All cases were a sporadic form of @entity10 . The age of onset ranged from 26 to 70 years (mean of 49.4 years). The male-to-female ratio was 31:1. All but two @entity0 were alcoholics with a daily intake of more than 80 g of @entity3 for at least 10 years. In metabolic studies of 17 @entity0 , a @entity8 or IV @entity7 was found in three @entity0 . High-density lipoprotein @entity2 values were higher in three @entity0 . A @entity5 tolerance test was abnormal in five @entity0 . A high prevalence of @entity1 was observed. Clinical signs of @entity6 were present in 11 of 13 @entity0 . Central nervous system involvement was found clinically in 3 of 13 @entity0 . CONCLUSION: The surgical removal of the fatty tissue and abstinence from @entity3 are essential for relieving the @entity0 from functional impairment. Not only metabolic studies of @entity9 but also a complete neurologic examination were required in order to improve the quality of life in @entity10 @entity0 .

title: XXXX : Korean experience.

answer: @entity10


abstract: UNASSIGNED: Currently, comprehensive genetic testing of @entity0 requires multiple testing strategies with high costs. Somatic mutations can be detected by next generation sequencing (NGS) but copy number variants (CNVs) require cytogenetic methods including karyotyping, fluorescence in  situ hybidization and microarray. Here, we evaluated a new method for @entity1 detection using read depth data derived from a targeted NGS mutation panel. In a cohort of 270 samples, we detected pathogenic mutations in 208 samples and targeted CNVs in 68 cases. The most frequent CNVs were 7q deletion including @entity11 and @entity9 , @entity3 deletion, @entity6 deletion, gain of @entity10 on 8q, and 5q deletion, including @entity8 and @entity5 . We were also able to detect exon-level duplications, including so-called @entity7 ( @entity7 ) partial tandem duplication, in 9 cases. In the 63 cases that were negative for mutations, targeted CNVs were observed in 4 cases. Targeted @entity1 detection by NGS had very high concordance with single nucleotide polymorphism microarray, the current gold standard. We found that @entity6 deletion was strongly associated with @entity3 alterations and 7q deletion was associated with mutations in @entity3 , @entity4 and @entity2 . This proof-of-concept study demonstrates the feasibility of using the same NGS data to simultaneously detect both somatic mutations and targeted CNVs.

title: Concurrent detection of targeted copy number variants and mutations using a XXXX next generation sequencing panel allows comprehensive genetic analysis using a single testing strategy.

answer: @entity0


abstract: OBJECTIVE: @entity3 has no observable symptom markers and there is little that the medical profession can do to help sufferers. Psychotherapy, antidepressants and drugs aimed at the most problematic symptoms have been shown to have limited efficacy. In an attempt to help understand the illness better, and to suggest alternative forms of intervention, the study tested whether outcome might be influenced by @entity0 ' representation of their illness and by their coping strategies. METHOD: All members of the @entity3 Network (an independent charitable support network based in the UK) were invited to participate via their quarterly newsletter, and 209 completed questionnaires were returned. @entity0 completed the Illness Perception Questionnaire (IPQ), the @entity4 , and the Hospital Anxiety and @entity2 Scale (HADS), and rated their quality of life and their satisfaction with their health. RESULTS: The reporting of serious consequences was associated with lower quality of life and lower satisfaction with health, and with higher scores for @entity1 and @entity2 (p <.001). Weaker control beliefs were related to lower quality of life, lower satisfaction with health, and higher @entity2 scores (p <.01). Lower illness scores were associated with more satisfaction with health (p <.01), but not with quality of life (p >.05). Psychological causal attribution of @entity3 was positively correlated with @entity1 (p <.001) and @entity2 (p <.01). Path analyses based on multiple linear regression demonstrated that (1) the reporting of serious consequences was a strong independent predictor of outcome; (2) coping mediated the link between representation and outcome; and (3) when predicting @entity2 , coping strategies predicted coping independently of representation dimensions. CONCLUSIONS: The findings indicate that the illness representations of @entity3 sufferers can have significant implications for outcome. Therapeutic interventions based on illness representations may prove useful for treatment.

title: Illness representation, coping and outcome in XXXX ( @entity3 ).

answer: @entity3


abstract: OBJECTIVE: @entity3 has no observable symptom markers and there is little that the medical profession can do to help sufferers. Psychotherapy, antidepressants and drugs aimed at the most problematic symptoms have been shown to have limited efficacy. In an attempt to help understand the illness better, and to suggest alternative forms of intervention, the study tested whether outcome might be influenced by @entity0 ' representation of their illness and by their coping strategies. METHOD: All members of the @entity3 Network (an independent charitable support network based in the UK) were invited to participate via their quarterly newsletter, and 209 completed questionnaires were returned. @entity0 completed the Illness Perception Questionnaire (IPQ), the @entity4 , and the Hospital Anxiety and @entity2 Scale (HADS), and rated their quality of life and their satisfaction with their health. RESULTS: The reporting of serious consequences was associated with lower quality of life and lower satisfaction with health, and with higher scores for @entity1 and @entity2 (p <.001). Weaker control beliefs were related to lower quality of life, lower satisfaction with health, and higher @entity2 scores (p <.01). Lower illness scores were associated with more satisfaction with health (p <.01), but not with quality of life (p >.05). Psychological causal attribution of @entity3 was positively correlated with @entity1 (p <.001) and @entity2 (p <.01). Path analyses based on multiple linear regression demonstrated that (1) the reporting of serious consequences was a strong independent predictor of outcome; (2) coping mediated the link between representation and outcome; and (3) when predicting @entity2 , coping strategies predicted coping independently of representation dimensions. CONCLUSIONS: The findings indicate that the illness representations of @entity3 sufferers can have significant implications for outcome. Therapeutic interventions based on illness representations may prove useful for treatment.

title: Illness representation, coping and outcome in @entity3 ( XXXX ).

answer: @entity3


abstract: INTRODUCTION: Clinicians switch from one @entity5 agonist to another for various reasons. However, each change may inadvertently result in certain potential risks such as decreased medication efficacy or new side-effects. OBJECTIVE: We evaluated the tolerability of a switch of @entity7 to @entity8 using two conversion ratios as a primary outcome measure, with motor function as a secondary outcome measure, in @entity0 with mild to moderate @entity2 ( @entity2 ). METHODS: Twenty consecutive @entity0 with mild to moderate @entity2 (Hoehn and Yahr, stage II-III) on treatment with stable doses of @entity7 and levodopa were randomized to two groups of 10 @entity0 each, to receive @entity8 based on 1:5 or 1:10 conversion ratios. Blinded evaluations were performed: 1) @entity3 's Diseased Rating Scale (UPDRS) scores both in 'on' and 'off', 2) Open-ended interviews for adverse events, 3) Epworth Sleepiness Scale, 4) Purdue Pegboard assessment during 'on' and 'off', 5) Hand-arm movement test during 'on' and 'off', and 6) Walking test during 'on' and 'off'. RESULTS: Major adverse events included ' @entity1 ' in one @entity0 and minor side-effects included giddiness, @entity4 , @entity6 , sleepiness and lethargy. However, these were mild and 19 (95%) of the 20 @entity0 completed the study. There was a significant improvement in both the UPDRS 'off' total and motor scores at 1 month compared with baseline for the group on 1:10 ratio. The walking times during the 'off' state at 1 and 2 months were significantly better compared with baseline in the 1:5 group. There were otherwise no significant differences in the rating tests during both 'off' and 'on' states before and after the @entity7 switch. CONCLUSIONS: We demonstrated that @entity0 with mild to moderate @entity2 who were on relatively low doses of @entity7 can be safely switched to @entity8 based on a conversion ratio of either 1:5 or 1:10. However, the higher conversion ratio has to be carried out with caution in @entity0 with daytime somnolence.

title: @entity8 and XXXX in @entity2 : a single-blind crossover study.

answer: @entity7


abstract: INTRODUCTION: Clinicians switch from one @entity5 agonist to another for various reasons. However, each change may inadvertently result in certain potential risks such as decreased medication efficacy or new side-effects. OBJECTIVE: We evaluated the tolerability of a switch of @entity7 to @entity8 using two conversion ratios as a primary outcome measure, with motor function as a secondary outcome measure, in @entity0 with mild to moderate @entity2 ( @entity2 ). METHODS: Twenty consecutive @entity0 with mild to moderate @entity2 (Hoehn and Yahr, stage II-III) on treatment with stable doses of @entity7 and levodopa were randomized to two groups of 10 @entity0 each, to receive @entity8 based on 1:5 or 1:10 conversion ratios. Blinded evaluations were performed: 1) @entity3 's Diseased Rating Scale (UPDRS) scores both in 'on' and 'off', 2) Open-ended interviews for adverse events, 3) Epworth Sleepiness Scale, 4) Purdue Pegboard assessment during 'on' and 'off', 5) Hand-arm movement test during 'on' and 'off', and 6) Walking test during 'on' and 'off'. RESULTS: Major adverse events included ' @entity1 ' in one @entity0 and minor side-effects included giddiness, @entity4 , @entity6 , sleepiness and lethargy. However, these were mild and 19 (95%) of the 20 @entity0 completed the study. There was a significant improvement in both the UPDRS 'off' total and motor scores at 1 month compared with baseline for the group on 1:10 ratio. The walking times during the 'off' state at 1 and 2 months were significantly better compared with baseline in the 1:5 group. There were otherwise no significant differences in the rating tests during both 'off' and 'on' states before and after the @entity7 switch. CONCLUSIONS: We demonstrated that @entity0 with mild to moderate @entity2 who were on relatively low doses of @entity7 can be safely switched to @entity8 based on a conversion ratio of either 1:5 or 1:10. However, the higher conversion ratio has to be carried out with caution in @entity0 with daytime somnolence.

title: XXXX and @entity7 in @entity2 : a single-blind crossover study.

answer: @entity8


abstract: INTRODUCTION: Clinicians switch from one @entity5 agonist to another for various reasons. However, each change may inadvertently result in certain potential risks such as decreased medication efficacy or new side-effects. OBJECTIVE: We evaluated the tolerability of a switch of @entity7 to @entity8 using two conversion ratios as a primary outcome measure, with motor function as a secondary outcome measure, in @entity0 with mild to moderate @entity2 ( @entity2 ). METHODS: Twenty consecutive @entity0 with mild to moderate @entity2 (Hoehn and Yahr, stage II-III) on treatment with stable doses of @entity7 and levodopa were randomized to two groups of 10 @entity0 each, to receive @entity8 based on 1:5 or 1:10 conversion ratios. Blinded evaluations were performed: 1) @entity3 's Diseased Rating Scale (UPDRS) scores both in 'on' and 'off', 2) Open-ended interviews for adverse events, 3) Epworth Sleepiness Scale, 4) Purdue Pegboard assessment during 'on' and 'off', 5) Hand-arm movement test during 'on' and 'off', and 6) Walking test during 'on' and 'off'. RESULTS: Major adverse events included ' @entity1 ' in one @entity0 and minor side-effects included giddiness, @entity4 , @entity6 , sleepiness and lethargy. However, these were mild and 19 (95%) of the 20 @entity0 completed the study. There was a significant improvement in both the UPDRS 'off' total and motor scores at 1 month compared with baseline for the group on 1:10 ratio. The walking times during the 'off' state at 1 and 2 months were significantly better compared with baseline in the 1:5 group. There were otherwise no significant differences in the rating tests during both 'off' and 'on' states before and after the @entity7 switch. CONCLUSIONS: We demonstrated that @entity0 with mild to moderate @entity2 who were on relatively low doses of @entity7 can be safely switched to @entity8 based on a conversion ratio of either 1:5 or 1:10. However, the higher conversion ratio has to be carried out with caution in @entity0 with daytime somnolence.

title: @entity8 and @entity7 in XXXX : a single-blind crossover study.

answer: @entity2


abstract: BACKGROUND: Onychocryptosis, commonly referred to as @entity4 , has many therapeutic alternatives for its management. Although mild cases can be treated conservatively, in severe cases, surgical treatment is preferred. @entity2 gel sheeting is found to be effective in the treatment of @entity3 and keloids. OBJECTIVE: To document the effectiveness of @entity2 gel sheeting in the management of @entity0 with onychocryptosis and in the prevention of the recurrences by breaking the devil's circle, which usually took place after the surgical procedures used in the treatment of the onychocryptosis. METHODS: Fourteen @entity0 were enrolled in the study. Entry criteria required the presence of slight (2 @entity0 ), moderate (2 @entity0 ), or severe (10 @entity0 ) onychocryptosis. The simple technique used in the study was the excision of the one-quarter part of the lesional side of the nail plate without excising the granulation tissue. After 24 hours, the @entity2 was placed on the granulation tissue and the exposed nail bed. @entity2 gel sheet was bandaged loosely without applying any pressure. @entity0 entering the study were given detailed instructions in applying and using the gel for 12 hours during the daytime. The study lasted for 14 months and was composed of a treatment period of 4 months and a follow-up period of 10 months. The @entity0 were evaluated every 2 weeks in the first month and then monthly. The change in thickness of granulation tissue was evaluated by comparing them with the baseline photographs and those taken at each visit. RESULTS: The management and prevention of onychocryptosis were achieved in 12 of 14 @entity0 (85.71%). The @entity2 gel sheeting treatment was well tolerated except for an occasional transient exudation, which was resolved when the treatment was withdrawn. CONCLUSION: The results show that the new method that we used for the treatment of onychocryptosis is successful in reducing the thickness of the @entity1 nail fold and prevents the recurrence of the condition during the regrowth of the nail plate by breaking the devil's circle. The advantage of this method is that it is not destructive to the nail matrix and the adjacent tissue.

title: XXXX gel sheeting for the management and prevention of onychocryptosis.

answer: @entity2


abstract: We investigated the antioxidant potential of @entity5 (GA), a natural compound found in vegetal sources, on the motor and oxidative damages induced by lead. @entity0 exposed to lead (50 mg/kg, i.p., once a day, 5 days) were treated with GA (13.5mg/kg, p.o.) or @entity2 (110 mg/kg, i.p.) daily, for 3 days. Lead exposure decreased the locomotor and exploratory activities, reduced blood @entity7 activity, and increased brain @entity6 (CAT) activity without altering other antioxidant defenses. Brain @entity1 ( @entity1 ) estimated by lipid peroxidation (TBARS) and protein @entity4 were increased by lead. GA reversed the motor behavior parameters, the @entity7 activity, as well as the markers of @entity1 changed by lead exposure. CAT activity remained high, possibly as a compensatory mechanism to eliminate hydroperoxides during lead @entity3 . @entity2 , a conventional chelating agent, was not beneficial on the lead-induced motor behavior and oxidative damages. Both GA (less) and @entity2 (more) reduced the lead accumulation in brain tissue. Negative correlations were observed between the behavioral parameters and lipid peroxidation and the lead levels in brain tissue. In conclusion, GA may be an adjuvant in lead exposure, mainly by its antioxidant properties against the motor and oxidative damages resulting from such @entity3 .

title: Locomotor damage and brain XXXX induced by lead exposure are attenuated by @entity5 treatment.

answer: @entity1


abstract: We investigated the antioxidant potential of @entity5 (GA), a natural compound found in vegetal sources, on the motor and oxidative damages induced by lead. @entity0 exposed to lead (50 mg/kg, i.p., once a day, 5 days) were treated with GA (13.5mg/kg, p.o.) or @entity2 (110 mg/kg, i.p.) daily, for 3 days. Lead exposure decreased the locomotor and exploratory activities, reduced blood @entity7 activity, and increased brain @entity6 (CAT) activity without altering other antioxidant defenses. Brain @entity1 ( @entity1 ) estimated by lipid peroxidation (TBARS) and protein @entity4 were increased by lead. GA reversed the motor behavior parameters, the @entity7 activity, as well as the markers of @entity1 changed by lead exposure. CAT activity remained high, possibly as a compensatory mechanism to eliminate hydroperoxides during lead @entity3 . @entity2 , a conventional chelating agent, was not beneficial on the lead-induced motor behavior and oxidative damages. Both GA (less) and @entity2 (more) reduced the lead accumulation in brain tissue. Negative correlations were observed between the behavioral parameters and lipid peroxidation and the lead levels in brain tissue. In conclusion, GA may be an adjuvant in lead exposure, mainly by its antioxidant properties against the motor and oxidative damages resulting from such @entity3 .

title: Locomotor damage and brain @entity1 induced by lead exposure are attenuated by XXXX treatment.

answer: @entity5


abstract: CONTEXT: @entity0 with @entity1 often experience multiple concurrent symptoms. Few studies have explored symptom clusters (SCs) in this population. OBJECTIVES: The aim of the present study was to explore SCs in @entity1 , evaluate the characteristics associated with various clusters, and determine their relationship to survival. METHODS: This study included @entity0 in the palliative care program of the Hospital Universitario La Paz from 2003 to 2005. The Edmonton Symptom Assessment System and a supplement including 13 other symptoms were used to detect symptoms. Principal component analysis was performed to determine symptom relationships and compare SCs with associated parameters. RESULTS: In total, 406 @entity0 were included, 61% @entity0 and 39% @entity0 . The median age was 66.4 (range 18-95). The most common primaries were gastrointestinal (35%), lung (25%), genitourinary (8%), breast (5%), and @entity4 . The following clusters were identified: @entity11 ( @entity3 , @entity12 , @entity7 ), neuropsychological ( @entity5 , @entity6 , and @entity2 ), @entity13 ( @entity13 , @entity8 , and tiredness), and gastrointestinal ( @entity9 and @entity10 ). The presence of these SCs was influenced by primary @entity1 site, gender, age, and performance status. Survival was related to the number of SCs present in a given @entity0 : zero SC, 52 days; one SC, 38 days; two SCs, 23 days; and three to four SCs, 19 days; P < 0.001. CONCLUSION: Different SCs can be identified in @entity0 with @entity1 . These SCs are influenced by primary @entity1 site, gender, age, and Eastern Cooperative Oncology Group performance status, and they can have prognostic value.

title: Symptom clusters in XXXX .

answer: @entity1


abstract: A moving correlation index (Mx-CPP) of cerebral perfusion pressure (CPP) and mean middle cerebral artery blood flow velocity (CBFV) allows continuous monitoring of dynamic @entity5 ( @entity5 ) in @entity0 with severe @entity1 ( @entity1 ). In this study we validated Mx-CPP for @entity1 , examined its prognostic relevance, and assessed its relationship with @entity3 ( @entity3 ), CPP, @entity2 ( @entity2 ), and CBFV. We tested whether using @entity3 instead of CPP for Mx calculation (Mx- @entity3 ) produces similar results. Mx was calculated for each hemisphere in 37 @entity1 @entity0 during the first 5 days of treatment. All @entity0 received sedation and @entity4 . CPP and bilateral CBFV were recorded, and GOS was estimated at discharge. Both Mx indices were calculated from 10,000 data points sampled at 57.4Hz. Mx-CPP > 0.3 indicates impaired @entity5 ; in these @entity0 CPP had a significant positive correlation with CBFV, confirming failure of @entity5 , while in those with Mx < 0.3, CPP was not correlated with CBFV, indicating intact @entity5 . These findings were confirmed for Mx- @entity3 . We found a significant correlation between impaired @entity5 , indicated by Mx- @entity6 and Mx- @entity3 , and poor outcome for @entity1 @entity0 . @entity3 , CPP, @entity2 , and CBFV were not correlated with @entity5 but it must be noted that our average CPP was considerably higher than in other studies. This study confirms the validity of this index to demonstrate @entity5 preservation or failure in @entity1 . This index is also valid if @entity3 is used instead of CPP, which eliminates the need for @entity2 for @entity5 assessment. An unfavorable outcome is associated with early @entity5 failure. Further studies using the Mx- @entity3 will reveal whether @entity5 improves along with @entity0 ' clinical improvement.

title: Noninvasive cerebrovascular autoregulation assessment in XXXX : validation and utility.

answer: @entity1


abstract: @entity1 homozygous for the mutation @entity5 develop a lethal @entity0 ( @entity0 ) and have abnormal elevations of @entity4 in the postnatal period. We examined the development of these elevated glucocorticoid levels in early life. The histological progression of a cystic lesion of the biliary ducts in older heterozygotes was also studied. Normal @entity1 had low (less than 85 nmol/liter) or undetectable (less than 36 nmol/liter) levels from the sixth to twelfth day of life. @entity4 levels were significantly higher in all homozygote ( @entity5 / @entity5 ) and some of the normal sibs, who were presumed to be heterozygote ( @entity5 /+) @entity1 compared to age-matched controls from day seven to 12. @entity4 levels were similar from the fifteenth day. A significant proportion of adult obligate heterozygotes from breeding pairs were found to have focal areas of @entity3 of the biliary ducts, in the absence of any @entity0 . The incidence of this lesion increased with age (10% at 150 days, 23% at 300 days, 29% at 450 days, 65% at greater than 450 days of age). The livers of homozygote @entity1 dying in infancy, and control adult @entity1 of the C57BL/6J background strain were free of cysts. The finding of @entity2 is reminiscent of adult type @entity0 . The @entity5 model thus supports the concept that the different forms of @entity0 may represent varying expression of a similar gene complex.

title: Polycystic kidney and liver disease and @entity4 changes in the XXXX @entity1 .

answer: @entity5


abstract: @entity1 homozygous for the mutation @entity5 develop a lethal @entity0 ( @entity0 ) and have abnormal elevations of @entity4 in the postnatal period. We examined the development of these elevated glucocorticoid levels in early life. The histological progression of a cystic lesion of the biliary ducts in older heterozygotes was also studied. Normal @entity1 had low (less than 85 nmol/liter) or undetectable (less than 36 nmol/liter) levels from the sixth to twelfth day of life. @entity4 levels were significantly higher in all homozygote ( @entity5 / @entity5 ) and some of the normal sibs, who were presumed to be heterozygote ( @entity5 /+) @entity1 compared to age-matched controls from day seven to 12. @entity4 levels were similar from the fifteenth day. A significant proportion of adult obligate heterozygotes from breeding pairs were found to have focal areas of @entity3 of the biliary ducts, in the absence of any @entity0 . The incidence of this lesion increased with age (10% at 150 days, 23% at 300 days, 29% at 450 days, 65% at greater than 450 days of age). The livers of homozygote @entity1 dying in infancy, and control adult @entity1 of the C57BL/6J background strain were free of cysts. The finding of @entity2 is reminiscent of adult type @entity0 . The @entity5 model thus supports the concept that the different forms of @entity0 may represent varying expression of a similar gene complex.

title: Polycystic kidney and liver disease and XXXX changes in the @entity5 @entity1 .

answer: @entity4


abstract: @entity1 homozygous for the mutation @entity5 develop a lethal @entity0 ( @entity0 ) and have abnormal elevations of @entity4 in the postnatal period. We examined the development of these elevated glucocorticoid levels in early life. The histological progression of a cystic lesion of the biliary ducts in older heterozygotes was also studied. Normal @entity1 had low (less than 85 nmol/liter) or undetectable (less than 36 nmol/liter) levels from the sixth to twelfth day of life. @entity4 levels were significantly higher in all homozygote ( @entity5 / @entity5 ) and some of the normal sibs, who were presumed to be heterozygote ( @entity5 /+) @entity1 compared to age-matched controls from day seven to 12. @entity4 levels were similar from the fifteenth day. A significant proportion of adult obligate heterozygotes from breeding pairs were found to have focal areas of @entity3 of the biliary ducts, in the absence of any @entity0 . The incidence of this lesion increased with age (10% at 150 days, 23% at 300 days, 29% at 450 days, 65% at greater than 450 days of age). The livers of homozygote @entity1 dying in infancy, and control adult @entity1 of the C57BL/6J background strain were free of cysts. The finding of @entity2 is reminiscent of adult type @entity0 . The @entity5 model thus supports the concept that the different forms of @entity0 may represent varying expression of a similar gene complex.

title: Polycystic kidney and liver disease and @entity4 changes in the @entity5 XXXX .

answer: @entity1


abstract: To investigate the relationship between @entity6 and age-associated changes in the normal @entity0 kidney, autopsy findings and renal histology from 57 individuals with mild systemic @entity6 (group I), were compared to 57 sex- and age-matched individuals with moderate-to-severe @entity6 (group II). Age, sex, body build, the presence or absence of @entity2 , semiquantitative aorta and coronary-artery @entity6 scores, organ weights, and the percent of globally @entity7 glomeruli were determined in each. Glomerular area, arcuate/interlobular arteries, and percent @entity1 were measured using standard morphometric techniques. Group I individuals had a 8.3 +/- 7.0% incidence of @entity7 glomeruli, compared to 15.4 +/- 16.3% in group II (mean +/- SD, P less than 0.01). Relative intrarenal arterial wall area was increased in group II (60 +/- 12%) compared to group I (55 +/- 11%, P less than 0.05). The mean glomerular area of nonsclerotic glomeruli was greater in group II (23,700 +/- 6,000 sq mu) than in group I (19,600 +/- 3,700 sq mu, P less than 0.01), suggesting that there were compensatory increases in glomerular size in group II. Interstitial @entity1 was similar in both groups. The relative impact of age, sex, body build, @entity2 , systemic @entity6 , @entity4 and @entity1 on @entity5 and glomerular size was investigated using multiple linear regression. Both age and @entity4 exhibited highly significant, independent associations with @entity5 . Glomerular area was positively correlated with heart weight and @entity3 . In contrast, there was no independent correlation between glomerular area and @entity5 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Relationship between XXXX and age-associated changes in the @entity0 kidney.

answer: @entity4


abstract: To investigate the relationship between @entity6 and age-associated changes in the normal @entity0 kidney, autopsy findings and renal histology from 57 individuals with mild systemic @entity6 (group I), were compared to 57 sex- and age-matched individuals with moderate-to-severe @entity6 (group II). Age, sex, body build, the presence or absence of @entity2 , semiquantitative aorta and coronary-artery @entity6 scores, organ weights, and the percent of globally @entity7 glomeruli were determined in each. Glomerular area, arcuate/interlobular arteries, and percent @entity1 were measured using standard morphometric techniques. Group I individuals had a 8.3 +/- 7.0% incidence of @entity7 glomeruli, compared to 15.4 +/- 16.3% in group II (mean +/- SD, P less than 0.01). Relative intrarenal arterial wall area was increased in group II (60 +/- 12%) compared to group I (55 +/- 11%, P less than 0.05). The mean glomerular area of nonsclerotic glomeruli was greater in group II (23,700 +/- 6,000 sq mu) than in group I (19,600 +/- 3,700 sq mu, P less than 0.01), suggesting that there were compensatory increases in glomerular size in group II. Interstitial @entity1 was similar in both groups. The relative impact of age, sex, body build, @entity2 , systemic @entity6 , @entity4 and @entity1 on @entity5 and glomerular size was investigated using multiple linear regression. Both age and @entity4 exhibited highly significant, independent associations with @entity5 . Glomerular area was positively correlated with heart weight and @entity3 . In contrast, there was no independent correlation between glomerular area and @entity5 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Relationship between @entity4 and age-associated changes in the XXXX kidney.

answer: @entity0


abstract: Three reported episodes of @entity3 , where 1:1000 @entity2 was not immediately obtainable, triggered us to assess its availability on all adult wards. We found @entity2 was unavailable on 50% of audited wards. A questionnaire for doctors and nurses revealed lack of knowledge on both the management of @entity3 and location of emergency drugs. Given that @entity3 is a treatable but potentially fatal condition, we held a meeting to discuss the situation with senior pharmacists, resuscitation managers, and senior doctors. Our intervention was to advise the production of ' @entity3 packs' as part of the crash trolley kit. This was to be added to the laminated crash trolley check list and to include @entity2 , @entity4 , @entity1 , and the @entity3 algorithm. The aim was to improve ward stock, staff knowledge, and create a consistent location for emergency drugs, so minimising @entity0 error, and @entity0 harm. With a PDSA approach we trialled the intervention on four pilot wards. The packs have now been dispersed trust-wide. Re-audit at four months showed 100% ward stock of @entity3 packs, more consistent drug location and improved staff knowledge. There were 17 coded incidents of @entity3 at this hospital in 2011, the actual figure likely being higher. We feel our project has greatly improved @entity0 safety in this area.

title: Introduction of 'Anaphylaxis Packs' to improve XXXX safety in a hospital setting.

answer: @entity0


abstract: PURPOSE: To report the effect of high-dose intravenous corticosteroid pulse therapy with and without orbital radiotherapy on Graves' @entity5 . DESIGN: Nonrandomized clinical trial. METHODS: We selected 39 Japanese @entity0 (age range, 22-64 years; mean, 48 years; 31 @entity0 , 8 @entity0 ) who had active Graves' @entity5 among 195 consecutive @entity0 . In the first 20 @entity0 , high-dose intravenous @entity3 pulse therapy (1 g per day for 3 successive days, repeated 3 times within 3 weeks) followed by 24-Gy orbital radiotherapy was performed. In the other 19 of the 39 @entity0 , high-dose intravenous @entity3 pulse therapy without orbital radiotherapy was performed. Coronal computed tomography (CT) of the orbit and exophthalmometry were performed before the corticosteroid pulse therapy, and 1 and 6 months after the corticosteroid pulse therapy. The maximum coronal section area of the most @entity2 rectus muscle in each eye was measured based on orbital CT imaging. RESULTS: Clinical findings at study entry were not significantly different between the two groups. No significant difference was found in the maximum coronal section area of the most @entity2 rectus muscle and the results of exophthalmometry measurements in both groups before the therapy. Extraocular muscle @entity2 was significantly reduced 1 month and 6 months after the therapy (P < .01) in both groups. However, no beneficial therapeutic effect on @entity4 was observed in either group at 1 month and 6 months after the therapy. No significant difference in the therapeutic effect on extraocular muscle @entity2 and @entity4 was found between the two groups. CONCLUSIONS: Orbital irradiation after @entity1 pulse therapy had no beneficial therapeutic effects on rectus muscle @entity2 or @entity4 of active Graves' @entity5 during the 6-month follow-up period.

title: Effect of steroid pulse therapy with and without orbital radiotherapy on Graves' XXXX .

answer: @entity5


abstract: OBJECTIVE: @entity2 is an important complication in @entity0 undergoing open heart surgery. The aim of this prospective, contemporary study was to objectively measure neurocognitive brain function following mechanical mitral valve replacement and mitral valve repair. METHODS: Forty consecutive, unselected @entity0 (mechanical valve replacement n=20, mean age 65+/-14; valve repair n=20, mean age 64+/-7, P=0.896) entered this prospective, contemporary study. Neurocognitive function was objectively measured by means of P300 auditory evoked potentials (peak latencies, ms) and two standard psychometric tests (Mini Mental State Examination, Trailmaking Test A (TTA)), preoperatively, 7 days and 4 months postoperatively. RESULTS: Before operation, neurocognitive brain function was comparable in both @entity0 groups (mechanical valve replacement versus valve repair: P300 potentials 374+/-25 versus 378+/-46 ms; P=0.791 and TTA 57+/-15 versus 54+/-10 s; P=0.552). Following mechanical valve replacement, neurocognitive function continuously worsened (7 day-follow-up: P300 potentials 392+/-28, P=0.001 versus preop and TTA 65+/-17, P=0.0001; 4-month follow-up: P300 potentials 406+/-39, P=0.0004; TTA 69+/-17, P=0.0001). Interestingly, neurocognitive brain function was unaffected in @entity0 undergoing valve repair (7-day follow-up: P300 potentials 386+/-40, P=0.890 versus preop and TTA: 53+/-10, P=0.644; 4-month follow-up: P300 potentials 374+/-36, P=0.166 and TTA 54+/-11, P=0.147). At 4-month follow-up, @entity0 with mechanical prostheses performed worse as compared to valve repair (P300 potentials: P=0.024; TTA P=0.014). CONCLUSION: As shown by P300 auditory evoked potentials and Trailmaking Test A, there is marked @entity1 related to mechanical valve replacement, whereas mitral valve repair does not affect neurocognitive function. This finding supports the beneficial effect of mitral valve repair over mechanical valve replacement in the decision-making tree of borderline cases, which are suitable for both types of procedure.

title: XXXX following mitral valve surgery.

answer: @entity2


abstract: @entity1 ( @entity1 ) are a common presentation in a medical assessment unit, and we wanted to check compliance with hospital guidelines for antibiotic prescribing in @entity0 presenting to hospital with @entity1 . The guidelines are based on local organisms and sensitivities. A retrospective audit of 40 @entity0 records with positive urine cultures from July to August 2013 showed that 20% of @entity0 with culture confirmed @entity1 were not given antibiotics at all. Of those prescribed antibiotics, 25% were non-compliant with local policy, and nearly one in two @entity0 received more than one antibiotic. Furthermore, stop dates were not stated on 77% of the drug charts and duration of treatment ranged from one to 11 days. Interventions were then introduced in the form of group teaching sessions, proactive checks by Trust pharmacists and widely distributed posters, and the same data sets collected for April to March 2014 to assess for efficacy of the interventions. On re-auditing, 35% @entity0 were not prescribed any antibiotics. However, compliance with local policy was 100%, including 100% drug charts having a stop/review date stated. The overall duration of treatment now ranged from one to seven days, and fewer than one in four @entity0 had more than one antibiotic. Our results showed that improvement was needed in antibiotic stewardship, in particular with regards to compliance with the local guidelines and documentation of prescription. We have demonstrated that it is possible to improve compliance through teaching, by displaying information prominently, and vigilance by the clinical team. The outcome of this is a decreased number and duration of antibiotics prescribed, which has benefits for the @entity0 , the hospital, and the community as a whole. Further work would include interventions to improve the number of @entity0 who are missing antibiotic prescriptions altogether.

title: CQUIN audit for prescription of antibiotics for XXXX in an acute medical assessment unit.

answer: @entity1


abstract: INTRODUCTION: @entity11 is due to a microcrystalline infringement (hydroxyapatite or @entity10 ) of the retro-odontoidal ligament of atlas, often leading to the erroneous diagnosis of @entity3 or @entity5 . We report on three new cases diagnosed from 1996 to 1999. EXEGESIS: The @entity0 complained of cervicalgies, @entity1 or @entity2 . The initially evoked diagnoses were @entity3 , @entity6 or @entity4 . Clinical exam found @entity3 and an inflammatory syndrome in all @entity0 . Analysis of the cerebro-spinal fluid realised in two cases was normal. The diagnosis of crowned dens syndrome was assessed in two cases by cervical CT scan of @entity8 . In the third case, @entity7 of a wrist allowed this diagnosis. We report a probably non fortuitous case of crowned dens syndrome associated with @entity9 . A non steroidal anti-inflammatory treatment allowed a dramatic regression of clinical symptoms. CONCLUSION: This entity should be better known; it can mimick numerous diagnosis and be responsible for @entity2 in the long course.

title: [ XXXX : three new cases].

answer: @entity11


abstract: OBJECT: Stereotactic radiosurgery and fractionated stereotactic radiotherapy are commonly used in the treatment of residual or recurrent @entity1 and cavernous sinus. A major risk associated with radiosurgical or radiotherapy treatment of residual or recurrent @entity1 adjacent to normal functional pituitary gland is radiation of the pituitary, which frequently leads to the development of @entity12 . The authors have used a technique of pituitary transposition to reduce the radiation dose to the normal pituitary gland in cases of planned radiosurgical treatment of @entity2 within the cavernous sinus. Here, the authors analyze the long-term endocrinological outcomes in @entity0 with residual and recurrent @entity1 who undergo hypophysopexy and adjuvant radiosurgical or conformal fractionated radiotherapy treatment. METHODS: Pituitary transposition involves placement of a fat graft between the normal @entity6 in the cavernous sinus. A sellar exploration for @entity1 resection is performed, the pituitary gland is transposed from the region of the cavernous sinus, and the graft is interposed between the @entity6 . The @entity2 may then be treated with stereotactic radiosurgery or conformal fractionated radiation therapy. The authors evaluated endocrinological outcome, safety of the procedure, and @entity4 in @entity0 who underwent this procedure during a 7-year period. RESULTS: Hypophysopexy has been used in 34 @entity0 with nonfunctioning @entity6 (19), functional @entity6 (8), @entity11 (2), @entity8 (2), @entity5 (1), @entity10 (1), or @entity9 (1) involving the sella and cavernous sinus. Follow-up (radiographic and endocrinological) has been performed yearly in all @entity0 . Two @entity0 experienced @entity3 before radiosurgery (1 transient), but none of the @entity0 developed new @entity12 during the median 4-year follow-up (range 1-8 years) after radiosurgery or fractionated stereotactic radiotherapy. CONCLUSIONS: The increased distance between the normal @entity6 facilitates treatment of the @entity1 with radiosurgery or radiotherapy and effectively reduces the incidence of @entity7 to the normal pituitary gland when compared with historical controls.

title: Endocrinological outcome after pituitary transposition (hypophysopexy) and adjuvant radiotherapy for XXXX involving the cavernous sinus.

answer: @entity1


abstract: The ultimate goal of every @entity1 ( @entity1 ) treatment program is a high treatment success rate. Treatment success is extremely important because, when the rate is high, it significantly contributes to declining numbers of new cases by reducing the number and period of infectious cases, @entity1 morbidity and mortality, and prevents the emergence of resistant strains. Our aim was to decrease @entity1 mortality by increasing @entity3 @entity0 ' treatment success rate to at least 85 % in @entity4 Health District by end of July 2014. A systems and dialogic analysis of the public health system related to @entity1 @entity0 ' treatment revealed that it was not performing well; we found weak coverage and quality of @entity1 services, a poorly-functioning @entity1 health information system, poor-performing health workforce, poor availability of @entity2 tests and antiretroviral for @entity1 @entity0 , and low degree of @entity0 ' participation in their care. We redesigned the system to correct those weaknesses. The effectiveness of these changes was monitored using plan, do, study, act (PDSA) cycles. We increased @entity1 @entity0 success rate from 80% to 95% between February 2012 and July 2014.The mortality rate dropped from 13% to 3% and the failure to follow-up rate dropped from 3% to 2%. In conclusion, district health systems performance depends on factors such as the closeness of services to population; skilled workforce; the ability to collect and analyze data and use information for action; population empowerment, and good management and improvement capabilities of management team especially the public health director. High @entity1 @entity0 ' success rate depends also on the availability of antiretroviral drugs. It is highly important that every district health management team member develops improvement capabilities.

title: From many deaths to some few cases of drug-resistant tuberculosis: travelling with the systems quality improvement model in XXXX Health District, Togo.

answer: @entity4


abstract: We previously identified the @entity2 @entity6 ( @entity6 ; related to testes-specific, vespid, and pathogenesis proteins) gene as a direct target of @entity5 with proapoptotic activities in various @entity1 cell lines, including @entity4 . To test the therapeutic potential of @entity6 we constructed an adenoviral vector capable of efficient transduction and expression of @entity6 (AdmRTVP-1) and used this vector in an orthotopic, metastatic @entity2 model of @entity4 . A single intratumoral administration of AdmRTVP-1 gene therapy significantly reduced @entity1 wet weight compared with control Adbetagal-injected @entity1 at two time points after injection with two different vector doses (p < or = 0.01 at 7 and 14 days). Spontaneous @entity0 to lung was also significantly reduced (p < or = 0.02). Evaluation of treated @entity1 revealed increased apoptosis and lower microvessel density counts. In a @entity3 aortic ring sprouting assay, AdmRTVP-1 inhibited endothelial cell sprouting compared with Adbetagal, confirming its antiangiogenic activity. These therapeutic activities were associated with a significant increase in survival from 22.9 to 26.8 days (p = 0.003) in this @entity4 . Interestingly, there were significant increases in the infiltration of @entity1 -associated macrophages, dendritic cells, and CD8+ T cells, which persisted at 14 days posttreatment in the AdmRTVP-1-treated @entity1 compared with @entity1 . In addition, significantly increased natural killer and cytotoxic T lymphocyte activities were demonstrated in the @entity2 with AdmRTVP-1-treated @entity1 . The unique therapeutic properties of AdmRTVP-1 gene therapy demonstrated in this study provide new opportunities for gene and immunotherapy of @entity4 and potentially other @entity1 .

title: Adenoviral vector-mediated @entity6 gene therapy for XXXX .

answer: @entity4


abstract: We previously identified the @entity2 @entity6 ( @entity6 ; related to testes-specific, vespid, and pathogenesis proteins) gene as a direct target of @entity5 with proapoptotic activities in various @entity1 cell lines, including @entity4 . To test the therapeutic potential of @entity6 we constructed an adenoviral vector capable of efficient transduction and expression of @entity6 (AdmRTVP-1) and used this vector in an orthotopic, metastatic @entity2 model of @entity4 . A single intratumoral administration of AdmRTVP-1 gene therapy significantly reduced @entity1 wet weight compared with control Adbetagal-injected @entity1 at two time points after injection with two different vector doses (p < or = 0.01 at 7 and 14 days). Spontaneous @entity0 to lung was also significantly reduced (p < or = 0.02). Evaluation of treated @entity1 revealed increased apoptosis and lower microvessel density counts. In a @entity3 aortic ring sprouting assay, AdmRTVP-1 inhibited endothelial cell sprouting compared with Adbetagal, confirming its antiangiogenic activity. These therapeutic activities were associated with a significant increase in survival from 22.9 to 26.8 days (p = 0.003) in this @entity4 . Interestingly, there were significant increases in the infiltration of @entity1 -associated macrophages, dendritic cells, and CD8+ T cells, which persisted at 14 days posttreatment in the AdmRTVP-1-treated @entity1 compared with @entity1 . In addition, significantly increased natural killer and cytotoxic T lymphocyte activities were demonstrated in the @entity2 with AdmRTVP-1-treated @entity1 . The unique therapeutic properties of AdmRTVP-1 gene therapy demonstrated in this study provide new opportunities for gene and immunotherapy of @entity4 and potentially other @entity1 .

title: Adenoviral vector-mediated XXXX gene therapy for @entity4 .

answer: @entity6


abstract: In the U.S., where the prevalence of @entity2 2 @entity1 has reached epidemic proportions, many @entity0 with this disease are treated by primary care physicians in community-based systems, including accountable care organisations (ACOs). To address gaps in the quality of @entity1 care, national quality measures have been established, including @entity0 -centered measures adopted by the Centers for Medicare and Medicaid Services for its Shared Savings Program for ACOs. From a @entity0 -centered perspective, high-quality @entity1 care depends on effective communication between clinicians and @entity0 , along with @entity0 education and counseling about medications and lifestyle. We designed and implemented a quality improvement (QI) program for 30 primary care physicians treating @entity0 with @entity2 2 @entity1 in three structurally similar but geographically diverse ACOs. Retrospective chart audits were conducted before (n = 300) and after (n = 300) each physician participated in accredited continuing medical education (CME) courses that focused on QI strategies. Randomly selected charts were audited to measurably assess essential interventions for improved outcomes in @entity2 2 @entity1 including the physicians' documentation of @entity0 counseling and assessment of side effects, and @entity0 ' medication adherence status and changes in hemoglobin @entity3 ( @entity3 ) and body mass index (BMI). Paced educational interventions included a private performance improvement Internet live course conducted for each physician, small-group Internet live courses involving peer discussion, and a set of enduring materials, which were also multi-accredited for all clinicians in the physician's practice. Continual improvement cycles were guided by analysis of the baseline chart audits, quantitative survey data, and qualitative feedback offered by @entity0 . To extend the benefit of the education, the enduring materials were offered to the interprofessional team of clinicians throughout the U.S. who did not participate in the QI program. For brevity, this article presents outcomes of the 30 primary care physicians. Baseline to post-education improvements were observed for percentages of charts with documented assessment of medication side effects (+11%) and counseling about medication risks/benefits (+28%), medication adherence (+13%), and lifestyle modifications (+8%). Improvements were also observed for documented adherence to @entity1 medications (+24%) and first-to-last visit changes in @entity3 (-0.16%) and BMI (-2.1). The findings indicate a positive influence of QI education on primary care physicians' performance of @entity0 -centered quality measures and @entity0 outcomes.

title: Applying Quality Improvement into Systems-based Learning to Improve XXXX Outcomes in Primary Care.

answer: @entity1


abstract: INTRODUCTION: Comminuted @entity1 ( @entity3 ) continue to pose a challenge to orthopedic surgeons. When internal fixation is not possible, radial head arthroplasty has been advocated as the treatment of choice. The purpose of this retrospective study was to evaluate clinical and radiological short-term results of @entity0 with @entity1 treated with a cemented bipolar radial prosthesis. METHODS: Twelve @entity0 received cemented bipolar radial head hemiarthroplasty for comminuted @entity1 . In all @entity0 a CT scan was obtained prior to surgical treatment to assess all associated injuries. Postoperatively an early motion protocol was applied. All @entity0 were evaluated clinically and radiologically at an average of 12.7 months. RESULTS: According to the Mayo Modified Wrist Score, the Mayo Elbow Performance Score, the functional rating index of Broberg and Morrey, and the DASH Score good to excellent results were obtained. Grip strength and range of motion were almost at the level of the unaffected contralateral side. @entity0 satisfaction was high, no instability or signs of loosening of the implant, and only mild signs of @entity2 were seen. CONCLUSION: Overall good to excellent short-term results for primary arthroplasty for comminuted @entity1 were observed. These encouraging results warrant the conduction of further studies with long-term follow-up and more cases to see if these short-term results can be maintained over time.

title: One-year results of cemented bipolar radial head prostheses for comminuted XXXX .

answer: @entity1


abstract: OBJECTIVE: @entity2 is common after cardiac surgery but few studies have examined the relationship between postoperative neuropsychological test performance and everyday behavior. The influence of postoperative @entity1 on car driving has previously not been investigated. The purpose of this study was to evaluate neurocognitive function and driving performance after coronary artery bypass grafting (CABG). METHODS: Twenty-seven @entity0 who underwent coronary artery bypass grafting with standard cardiopulmonary bypass technique and 20 @entity0 scheduled for percutaneous coronary intervention (PCI) under local anesthesia (control group) were enrolled in this prospective study conducted from April 1999 to September 2000. Complete data were obtained in 23 and 19 @entity0 , respectively. The @entity0 underwent neuropsychological examination with a test battery including 12 tests, a standardized on-road driving test and a test in an advanced driving simulator before and 4-6 weeks after intervention. RESULTS: More @entity0 in the coronary artery bypass grafting group (n=11, 48%) than in the percutaneous coronary intervention group (n=2, 10%) showed a @entity1 after intervention (P=0.01). In the on-road driving test, @entity0 who underwent coronary artery bypass grafting deteriorated after surgery in the cognitive demanding parts like traffic behavior (P=0.01) and attention (P=0.04). @entity0 who underwent percutaneous intervention deteriorated in maneuvering of the vehicle (P=0.04). No deterioration was detected in the simulator in any of the groups after intervention. @entity0 with a @entity1 after intervention also tended to drop in the on-road driving scores to a larger extent than did @entity0 without a @entity1 . CONCLUSION: This study indicates that cognitive functions important for safe driving may be influenced after cardiac surgery.

title: XXXX and driving performance after coronary artery bypass surgery.

answer: @entity2


abstract: BACKGROUND: Minimally invasive surgery has been one of the recent developments in liver surgery, laparoscopic liver resection (LLR) was initially performed for benign lesions at easily accessible locations. As the surgical techniques, technology and experience improved over the past decades, LLR surgery had evolved to tackle malignant lesions, major resections and even in difficult locations without compromising safety and principles of oncology. It was also shown to be beneficial in cirrhotic @entity0 . We describe our initial experience with LLR in a population with significant proportion having @entity5 , emphasising our approach for lesions in the posterosuperior (PS) segments of the liver (segments 1, 4a, 7, and 8). METHODS: A review of @entity0 undergoing LLR in single institution from 2006 to 2015 was performed from a prospective surgical database. Clinicopathological, operative and perioperative parameters were analyzed to compare outcomes in @entity0 who underwent LLR for PS vs. @entity4 ( @entity4 ). RESULTS: LLR was performed in consecutive 197 @entity0 , with a mean age of 60 years. The indications for resection were @entity6 ( @entity6 ) (n=105; 53%), @entity3 liver @entity1 (n=31; 16%), other @entity2 (n=19; 10%) and benign lesions (n=42; 21%). A significant proportion had @entity8 (25.9%). More females underwent surgery in the @entity4 group and indications for surgery were similar between both groups. Major liver resection was performed more frequently for the PS group than for the @entity4 group (P<0.001) and significantly more PS resections was performed in our latter experience (P=0.02). The mean operative time and the conversion rate were significantly greater in the PS group than in the @entity4 group (P <=0.001 and 0.03, respectively). However, the estimated @entity7 (EBL), rate of blood transfusion and mean postoperative stay were similar in the two groups (P=0.04, 0.88 and 0.92, respectively). The overall 90-day morbidity and mortality rate was 21.3% and 0.5% respectively, with no differences between the two groups. Surrogates of difficulty such as operative time, @entity7 , conversion and outcomes e.g., morbidity and mortality, were similar in @entity0 who underwent PS resections with or without @entity5 . CONCLUSIONS: LLR in selected @entity0 is technically feasible and safe including cirrhotic @entity0 with lesions in the PS segments.

title: Laparoscopic liver resection for posterosuperior and XXXX -a comparison experience in an Asian centre.

answer: @entity4


abstract: AIM: To conduct an integrative review to examine evidence of @entity1 and associated symptoms in adult (>= 21  years of age), postcraniotomy, @entity5 @entity0 hospitalized on intensive care units. BACKGROUND: Healthcare providers believe craniotomies are less @entity1 . Understanding how @entity1 unfolds over time will help inform @entity0 care and aid in future research and policy development. DESIGN: Systematic literature search to identify relevant literature. Information abstracted using the Theory of Unpleasant Symptoms' concepts of influencing factors, symptom clusters and @entity0 performance. Inclusion criteria were indexed, peer-reviewed, full-length, English-language articles. Keywords were 'traumatic @entity6 ', ' @entity1 , post-operative', ' @entity6 ', ' @entity2 ', 'craniotomy', 'decompressive craniectomy' and 'trephining'. DATA SOURCES: Medline, OVID, PubMed and CINAHL databases from 2000-2014. REVIEW METHOD: Cooper's five-stage integrative review method was used to assess and synthesize literature. RESULTS: The search yielded 115 manuscripts, with 26 meeting inclusion criteria. Most studies were randomized, controlled trials conducted outside of the United States. All tested pharmacological @entity1 interventions. Postcraniotomy @entity5 @entity1 was well-documented and associated with @entity3 , @entity4 and changes in blood pressure, and it impacted the @entity0 's length of hospital stay, but there was no consensus for how best to treat such @entity1 . CONCLUSION: The Theory of Unpleasant Symptoms provided structure to the search. @entity1 is experienced by @entity0 , but associated symptoms and impact on @entity0 performance remain poorly understood. Further research is needed to improve understanding and management of @entity1 in this population.

title: Integrative review: postcraniotomy XXXX @entity0 .

answer: @entity5


abstract: AIM: To conduct an integrative review to examine evidence of @entity1 and associated symptoms in adult (>= 21  years of age), postcraniotomy, @entity5 @entity0 hospitalized on intensive care units. BACKGROUND: Healthcare providers believe craniotomies are less @entity1 . Understanding how @entity1 unfolds over time will help inform @entity0 care and aid in future research and policy development. DESIGN: Systematic literature search to identify relevant literature. Information abstracted using the Theory of Unpleasant Symptoms' concepts of influencing factors, symptom clusters and @entity0 performance. Inclusion criteria were indexed, peer-reviewed, full-length, English-language articles. Keywords were 'traumatic @entity6 ', ' @entity1 , post-operative', ' @entity6 ', ' @entity2 ', 'craniotomy', 'decompressive craniectomy' and 'trephining'. DATA SOURCES: Medline, OVID, PubMed and CINAHL databases from 2000-2014. REVIEW METHOD: Cooper's five-stage integrative review method was used to assess and synthesize literature. RESULTS: The search yielded 115 manuscripts, with 26 meeting inclusion criteria. Most studies were randomized, controlled trials conducted outside of the United States. All tested pharmacological @entity1 interventions. Postcraniotomy @entity5 @entity1 was well-documented and associated with @entity3 , @entity4 and changes in blood pressure, and it impacted the @entity0 's length of hospital stay, but there was no consensus for how best to treat such @entity1 . CONCLUSION: The Theory of Unpleasant Symptoms provided structure to the search. @entity1 is experienced by @entity0 , but associated symptoms and impact on @entity0 performance remain poorly understood. Further research is needed to improve understanding and management of @entity1 in this population.

title: Integrative review: postcraniotomy @entity5 XXXX .

answer: @entity0


abstract: A @entity6 associated with brief periods of @entity3 or acute @entity2 was noted in monkeys. Affected monkeys died unexpectedly or after a very short illness. Consistent gross findings at necropsy were enlarged, pale yellow livers, pale tan to yellow kidneys, abundant deposits of body fat and empty gastrointestinal tracts. @entity4 was the predominant and characteristic lesion found microscopically. Most of the monkeys were female @entity7 greater than 8 years of age. However, monkeys of other species and ages, and one male also died of this syndrome. Affected monkeys generally had losses of 8-33% of body weight (last measured weight--weight at @entity1 ). In some animals, this syndrome was associated with a location change forcing new social interactions. A common clinical pathologic finding was @entity5 . These findings suggest that @entity0 monkeys may be prone to a @entity6 characterized by @entity4 , and @entity2 .

title: Fatal XXXX in @entity0 monkeys.

answer: @entity4


abstract: A @entity6 associated with brief periods of @entity3 or acute @entity2 was noted in monkeys. Affected monkeys died unexpectedly or after a very short illness. Consistent gross findings at necropsy were enlarged, pale yellow livers, pale tan to yellow kidneys, abundant deposits of body fat and empty gastrointestinal tracts. @entity4 was the predominant and characteristic lesion found microscopically. Most of the monkeys were female @entity7 greater than 8 years of age. However, monkeys of other species and ages, and one male also died of this syndrome. Affected monkeys generally had losses of 8-33% of body weight (last measured weight--weight at @entity1 ). In some animals, this syndrome was associated with a location change forcing new social interactions. A common clinical pathologic finding was @entity5 . These findings suggest that @entity0 monkeys may be prone to a @entity6 characterized by @entity4 , and @entity2 .

title: Fatal @entity4 in XXXX monkeys.

answer: @entity0


abstract: UNASSIGNED: Mechanistic modeling of DNA double strand break (DSB) rejoining is important for quantifying and medically exploiting radiation-induced @entity2 (e.g. in @entity1 radiotherapy). Most radiation-induced DSBs are quickly-rejoinable and are rejoined within the first 1-2 hours after irradiation. Others are slowly-rejoinable (persist for several hours), and yet others are essentially unrejoinable (persist for >24 hours). The dependences of DSB rejoining kinetics on radiation dose and dose rate remain incompletely understood. We hypothesize that the fraction of slowly-rejoinable and/or unrejoinable DSBs increases with increasing dose/dose rate. This @entity4 ( @entity4 ) model was implemented using differential equations for three DSB classes: quickly-rejoinable, slowly-rejoinable and unrejoinable. Radiation converts quickly-rejoinable to slowly-rejoinable, and slowly-rejoinable to unrejoinable DSBs. We used large published data sets on DSB rejoining in @entity3 exposed to sparsely-ionizing (electrons and y-rays, single or split-doses, high or low dose rates) and densely-ionizing (a-particles) radiation to compare the performances of the proposed @entity4 formalism and the established two-lesion kinetic (TLK) model. These @entity3 DSB rejoining data were measured within the radiation dose range relevant for clonogenic cell survival, whereas in @entity0 cells DSB rejoining is usually measured only at supra-lethal doses for technical reasons. The @entity4 model described both sparsely-ionizing and densely-ionizing radiation data much better than the TLK model: by 217 and 14 sample-size-adjusted Akaike information criterion units, respectively. This occurred because: the @entity4 (but not the TLK) model reproduced the observed upwardly-curving dose responses for slowly-rejoinable/unrejoinable DSBs at long times after irradiation; the @entity4 model adequately described DSB yields at both high and low dose rates using one parameter set, whereas the TLK model overestimated low dose rate data. These results support the hypothesis that DSB rejoining is progressively impeded at increasing radiation doses/dose rates.

title: Mechanistic Modeling of Dose and Dose Rate Dependences of Radiation-Induced DNA Double Strand Break Rejoining Kinetics in XXXX .

answer: @entity3


abstract: BACKGROUND: Acute disseminated @entity6 (ADEM) is an inflammatory, @entity1 occurring several weeks after @entity7 . Enteroviruses have been described as potential triggers of ADEM, but the closely related parechoviruses have not. The objective of the study is to assess the prevalence and disease presentation of ADEM after @entity3 in a syndromic surveillance program for pediatric @entity8 (CNS). METHODS: The surveillance was conducted at the Charit   Department of Pediatrics in Berlin, Germany, from November 2010 to November 2014. All hospitalized @entity0 meeting predefined case criteria underwent highly standardized prospective clinical assessments based on the published case definitions, including for ADEM. Stool samples were independently analyzed by enterovirus and parechovirus real-time polymerase chain reaction at the Robert Koch Institute. RESULTS: Of 105,557 @entity0 screened, 774 (0.7%) fulfilled entry criteria for CNS @entity2 , with 114 cases ascertained as ADEM. Parechoviruses were detected in 2.5% of @entity0 with CNS @entity2 , including 1 case fulfilling ADEM case criteria with the highest level of diagnostic certainty. CONCLUSIONS: We report a first case of ADEM after @entity3 in a 5-year-old female presenting with @entity4 2 weeks after a @entity5 . Parechovirus disease should be included in the differential diagnosis of ADEM.

title: Acute Disseminated XXXX After Human Parechovirus Infection.

answer: @entity6


abstract: BACKGROUND: Prolonged preoperative @entity3 may impair nutritional status of the @entity0 and their recovery. In contrast, some studies show that @entity3 abbreviation can improve the response to @entity2 and decrease the length of hospital stay. AIM: Investigate whether the prescribed perioperative @entity3 time and practiced by @entity0 is in compliance with current multimodal protocols and identify the main factors associated. METHODS: Cross-sectional study with 65 @entity0 undergoing elective surgery of the digestive tract or abdominal wall. We investigated the @entity3 time in the perioperative period, hunger and thirst reports, physical status, @entity1 diagnosis, type of surgery and anesthesia. RESULTS: The @entity0 were between 19 and 87 years, mostly female (73.8%). The most performed procedure was cholecystectomy (47.69%) and general anesthesia the most used (89.23%). The most common approach was to start @entity3 from midnight for liquids and solids, and most of the @entity0 received grade II (64.6%) to the physical state. The real @entity3 average time was 16 h (9.5-41.58) was higher than prescribed (11 h, 6.58 -26.75). The @entity0 submitted to surgery in the afternoon were in more @entity3 time than those who did in the morning (p<0.001). The intensity of hunger and thirst increased in postoperative @entity3 period (p=0.010 and 0.027). The average period of postoperative @entity3 was 18.25 h (3.33-91.83) and only 23.07% restarted feeding on the same day. CONCLUSION: @entity0 were fasted for prolonged time, higher even than the prescribed time and intensity of the signs of discomfort such as hunger and thirst increased over time. To better recovery and the @entity0 's well-being, it is necessary to establish a preoperative @entity3 abbreviation protocol.

title: FASTING IN ELECTIVE SURGICAL XXXX : COMPARISON AMONG THE TIME PRESCRIBED, PERFORMED AND RECOMMENDED ON PERIOPERATIVE CARE PROTOCOLS.

answer: @entity0


abstract: Previous studies have shown that @entity6 plays a significant role in the outcome of @entity2 , but data related to the effect of stress on periodontal @entity3 is limited. The present study was designed to test the impact of emotional stress on the humoral immune response to the periodontal pathogen @entity7 in a @entity0 model of @entity1 . Chambers constructed from @entity5 wire were implanted in the subcutaneous dorsolumbar region of @entity0 . All @entity0 were immunized with @entity7 followed by an intrachamber challenge with the bacteria. One group of @entity0 was used as control, while the other two experienced experimental stress conditions (isolation/restraint stress). Stress-1 group was stressed during the immunization period, while Stress-2 group was stressed during the local challenge period. Chamber exudates and serum were collected and analyzed for levels of anti-P. gingivalis antibodies (IgG, @entity8 and @entity9 ). The levels of serum antibodies to @entity7 were not different between the three tested groups, excluding increased levels of @entity9 in Stress-1 group at baseline. The levels of antibodies in the chamber exudates were significantly lower in the stressed groups at baseline, but higher at d 7. The @entity8 to @entity9 ratio was significantly higher in the control group compared with the two stressed groups. The findings of the present study suggest that chronic @entity6 had a marked impact on the localized response to @entity7 challenge. The lower @entity8 / @entity9 ratio observed in the stress groups suggests elevated @entity4 response during stress.

title: The effect of chronic emotional stress on the humoral immune response to XXXX in @entity0 .

answer: @entity7


abstract: Previous studies have shown that @entity6 plays a significant role in the outcome of @entity2 , but data related to the effect of stress on periodontal @entity3 is limited. The present study was designed to test the impact of emotional stress on the humoral immune response to the periodontal pathogen @entity7 in a @entity0 model of @entity1 . Chambers constructed from @entity5 wire were implanted in the subcutaneous dorsolumbar region of @entity0 . All @entity0 were immunized with @entity7 followed by an intrachamber challenge with the bacteria. One group of @entity0 was used as control, while the other two experienced experimental stress conditions (isolation/restraint stress). Stress-1 group was stressed during the immunization period, while Stress-2 group was stressed during the local challenge period. Chamber exudates and serum were collected and analyzed for levels of anti-P. gingivalis antibodies (IgG, @entity8 and @entity9 ). The levels of serum antibodies to @entity7 were not different between the three tested groups, excluding increased levels of @entity9 in Stress-1 group at baseline. The levels of antibodies in the chamber exudates were significantly lower in the stressed groups at baseline, but higher at d 7. The @entity8 to @entity9 ratio was significantly higher in the control group compared with the two stressed groups. The findings of the present study suggest that chronic @entity6 had a marked impact on the localized response to @entity7 challenge. The lower @entity8 / @entity9 ratio observed in the stress groups suggests elevated @entity4 response during stress.

title: The effect of chronic emotional stress on the humoral immune response to @entity7 in XXXX .

answer: @entity0


abstract: @entity8 is a @entity6 , which frequently occurs in the ventricles and rarely in the spinal cord. Most of the @entity7 are subclinical and thus incidentally encountered at autopsy, whereas the spinal ones are inevitably accompanied by @entity4 and are often diagnosed clinically as @entity3 or @entity5 . Two cases of @entity4 are reported, one of which recurred 9 years after the initial operation. All specimens of both cases showed similar microscopic features. Within a highly fibrillary background, round to ovoid @entity0 cells were unevenly distributed and arranged in cell clusters. Mitoses were rarely encountered. No @entity1 was demonstrated in any of the specimens. Ultrastructural examination demonstrated many slender processes containing abundant intermediate filaments and occasional small lumen-like structures with many microvillous projections and cell junctions. @entity8 arising in the spinal cord should be distinguished from other more @entity2 , such as diffuse @entity5 and @entity3 . Characteristic microscopic features and the ultrastructural studies support the diagnosis.

title: XXXX of the spinal cord and review of the literature.

answer: @entity8


abstract: BACKGROUND: The purpose of the present paper was to review the initial experience of an endovascular aortic stent graft program at a major teaching hospital in Hong Kong. METHODS: Demographics, operative details, complications and follow-up data of all the @entity0 receiving endovascular repair for @entity7 were recorded prospectively. RESULTS: Between July 1999 and December 2001, endovascular repairs were attempted in 39 @entity0 with @entity7 . The procedural success rate was 97.4%. Thirty-three procedures were for abdominal aorto-iliac @entity3 . Graft configuration was bifurcated in 28 @entity0 (85%) while an aorto-uni-iliac device with a femoro-femoral bypass was carried out in the remaining five @entity0 . Thoracic procedures were carried out for one thoracic aortic @entity3 , two traumatic thoracic aortic injuries, one @entity4 , and one thoracic aortic @entity8 with @entity5 . There was one hospital mortality (2.6%) from a type A @entity4 with @entity6 . @entity1 were seen in seven @entity0 (18%). With a mean follow-up of 11.6 +/- 8.1 months, there was no open conversion or @entity2 . The endoleak rate was 27% at discharge, 15% at 6 months and 5% at 12 months postoperatively. For @entity3 endografts, the @entity3 sac decreased in size in 21 @entity0 (62%), and remained static in 13 @entity0 (38%). CONCLUSIONS: The endoluminal stent graft appears to be a promising device that can be used safely in selected @entity0 with @entity7 . Continued follow-up is required to monitor the presence of endoleak and the size of the @entity3 sac.

title: Endoluminal stent grafts for XXXX : experience at a major teaching hospital in Hong Kong.

answer: @entity7


abstract: A 43-year-old @entity0 , with a chief complaint of @entity4 and a palpable mass in the lower abdomen, was admitted to this hospital. He had 2-3 episodes of @entity3 monthly for several years. Laparotomy revealed the mass resembling @entity1 , invaded the ileum and bladder and also it had disseminated lesions in the other intraabdominal organs. Resected tissues showed actinomycotic abscess. AB-PC was administered post-operatively, with a satisfactory prognosis. On the 71 @entity0 with @entity7 who underwent laparotomy during the past 32 years in Japan, 42 were males and 28 females. Many of them were in their forties or fifties. Some literatures mention the ileocecal region as the usual site of following perforated @entity6 . As far as this review is concerned, however, the transverse colon was as frequently affected as the ileocecal region and it was only in 13 @entity0 that @entity5 preceded the @entity2 . @entity7 is not an uncommon disease and should be taken into consideration in the differential diagnosis of the abdominal mass.

title: [A case of XXXX ].

answer: @entity7


abstract: @entity0 major urinary proteins (MUPs) are encoded by a family of about 35 to 40 highly conserved genes. In the preceding paper (K. Shahan, M. Gilmartin, and E. Derman, Mol. Cell. Biol. 7:1938-1946, 1987), we presented the sequences of the most abundant @entity2 mRNAs in the liver ( @entity2 I, II, and III) and in the lachrymal ( @entity2 IV) and submaxillary ( @entity3 ) glands. We have shown that these five mRNAs are coded by five distinct genes, @entity2 I through V. In the present communication, we examine the expression of @entity2 genes in all of the six tissues in which @entity2 mRNAs are synthesized, the mammary, parotid, @entity1 . We show that gene @entity2 II is expressed in the liver and in the mammary gland, that gene @entity2 IV is expressed in the lachrymal and parotid glands, and that gene @entity3 is expressed in the submaxillary, sublingual, and lachrymal and parotid glands, and that gene @entity3 is expressed in the submaxillary, sublingual, and lachrymal glands. Furthermore, we present evidence that in addition to genes @entity2 I through V, another gene, @entity2 VI, is expressed in BALB/c @entity0 in the parotid gland. The tissue-specific synthesis of @entity2 mRNAs is thus brought about by two major mechanisms: the expression, in different tissues, of different members of the family and the expression of a single gene at various levels in different tissues. When a particular @entity2 gene is expressed in several tissues, transcripts of this gene initiate at the same site and are spliced and polyadenylated in the same manner.

title: Expression of six XXXX major urinary protein genes in the mammary, parotid, sublingual, submaxillary, and lachrymal glands and in the liver.

answer: @entity0


abstract: Physical exercise is considered to exert a positive effect on health, whereas strenuous or excessive exercise (Exe) causes @entity2 and damage to muscle and immune functions. The underlying molecular mechanisms are still unclear. We designed a protocol to mimic Exe and explore the ensuing cellular damage and involvement of mitochondrial dynamics. We found that Exe was prone to decrease endurance capacity and induce @entity0 and the immune system. Muscle atrophy markers @entity9 and @entity10 mRNA were increased by Exe, accompanied by increased autophagy and mitochondrial fission in skeletal muscle. Exe caused a decrease in @entity6 and complex I expression; it also activated JNK and @entity4 pathways and consequently induced @entity8 , @entity7 , and MnSOD expression in skeletal muscle. The involvement of oxidant-induced autophagy and @entity3 was confirmed in C2C12 myoblasts. @entity11 (HT), a natural olive @entity5 , efficiently enhanced endurance capacity and prevented Exe-induced @entity0 . Also, HT treatment inhibited both the Exe-induced increase in autophagy and mitochondrial fission and the decrease in @entity6 expression. In addition, HT enhanced mitochondrial fusion and mitochondrial complex I and II activities in muscle of Exe @entity1 . These results demonstrate that Exe-induced @entity2 and damage to muscle and immune functions may be mediated via the regulation of mitochondrial dynamic remodeling, including the downregulation of mitochondrial biogenesis and upregulation of autophagy. HT supplementation may regulate mitochondrial dynamic remodeling and enhance antioxidant defenses and thus improve exercise capacity under Exe conditions.

title: Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and @entity3 : regulatory effects of XXXX .

answer: @entity11


abstract: Physical exercise is considered to exert a positive effect on health, whereas strenuous or excessive exercise (Exe) causes @entity2 and damage to muscle and immune functions. The underlying molecular mechanisms are still unclear. We designed a protocol to mimic Exe and explore the ensuing cellular damage and involvement of mitochondrial dynamics. We found that Exe was prone to decrease endurance capacity and induce @entity0 and the immune system. Muscle atrophy markers @entity9 and @entity10 mRNA were increased by Exe, accompanied by increased autophagy and mitochondrial fission in skeletal muscle. Exe caused a decrease in @entity6 and complex I expression; it also activated JNK and @entity4 pathways and consequently induced @entity8 , @entity7 , and MnSOD expression in skeletal muscle. The involvement of oxidant-induced autophagy and @entity3 was confirmed in C2C12 myoblasts. @entity11 (HT), a natural olive @entity5 , efficiently enhanced endurance capacity and prevented Exe-induced @entity0 . Also, HT treatment inhibited both the Exe-induced increase in autophagy and mitochondrial fission and the decrease in @entity6 expression. In addition, HT enhanced mitochondrial fusion and mitochondrial complex I and II activities in muscle of Exe @entity1 . These results demonstrate that Exe-induced @entity2 and damage to muscle and immune functions may be mediated via the regulation of mitochondrial dynamic remodeling, including the downregulation of mitochondrial biogenesis and upregulation of autophagy. HT supplementation may regulate mitochondrial dynamic remodeling and enhance antioxidant defenses and thus improve exercise capacity under Exe conditions.

title: Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and XXXX : regulatory effects of @entity11 .

answer: @entity3


abstract: OBJECTIVE: To evaluate the value of perfusion MR imaging and angiographic evidence of collateral circulation in symptomatic @entity0 with @entity1 ( @entity1 ). METHODS: Cerebral angiography and perfusion MR were performed in 16 @entity0 with symptoms of @entity1 . Qualitative perfusion maps were calculated for regional cerebral blood volume (rCBV) and mean transit time ( @entity2 ). RESULTS: A total of 27 lesions were seen on the perfusion MR maps (6 @entity3 and 21 @entity4 ) and most of them (26/27) showed a prolonged @entity2 . @entity2 is sensitive to the presence of @entity4 , but not sufficient in distinguishing @entity3 from @entity1 . All of the @entity3 showed a decreased rCBV, while most of the @entity4 showed a normal or increased rCBV. When collateral circulation was identified on angiography, most @entity4 were not @entity3 and had a normal or increased rCBV. The absence of angiographically identifiable cerebral collaterals may not always result in an @entity3 ; 50% had decreased rCBV. Despite the absence of angiographic collaterals, the other half had normal or increased rCBV. CONCLUSION: Cerebral angiographic evidence of collateral circulation is important in identifying a favorable outcome in @entity0 with @entity1 . However, a lesion with a normal or increased rCBV suggests a sufficient collateral circulation even without angiographic collaterals. Perfusion images may be a potentially useful adjunctive tool in the prediction of the outcome of @entity1 , particularly where no apparent collateral macrocirculation is seen on CA.

title: Cerebral angiography and MR perfusion images in @entity0 with XXXX .

answer: @entity4


abstract: OBJECTIVE: To evaluate the value of perfusion MR imaging and angiographic evidence of collateral circulation in symptomatic @entity0 with @entity1 ( @entity1 ). METHODS: Cerebral angiography and perfusion MR were performed in 16 @entity0 with symptoms of @entity1 . Qualitative perfusion maps were calculated for regional cerebral blood volume (rCBV) and mean transit time ( @entity2 ). RESULTS: A total of 27 lesions were seen on the perfusion MR maps (6 @entity3 and 21 @entity4 ) and most of them (26/27) showed a prolonged @entity2 . @entity2 is sensitive to the presence of @entity4 , but not sufficient in distinguishing @entity3 from @entity1 . All of the @entity3 showed a decreased rCBV, while most of the @entity4 showed a normal or increased rCBV. When collateral circulation was identified on angiography, most @entity4 were not @entity3 and had a normal or increased rCBV. The absence of angiographically identifiable cerebral collaterals may not always result in an @entity3 ; 50% had decreased rCBV. Despite the absence of angiographic collaterals, the other half had normal or increased rCBV. CONCLUSION: Cerebral angiographic evidence of collateral circulation is important in identifying a favorable outcome in @entity0 with @entity1 . However, a lesion with a normal or increased rCBV suggests a sufficient collateral circulation even without angiographic collaterals. Perfusion images may be a potentially useful adjunctive tool in the prediction of the outcome of @entity1 , particularly where no apparent collateral macrocirculation is seen on CA.

title: Cerebral angiography and MR perfusion images in XXXX with @entity4 .

answer: @entity0


abstract: CT-guided stereotactic brachytherapy has been performed for the deep-seated @entity1 using the double-catheter after-loading method. The catheter system consists of two coaxial @entity2 tubes with closed @entity4 . The outer catheter is 3.0 mm in outer diameter and 2.4 mm in inner diameter. The inner catheter is 2.0 mm in outside diameter and 1.4 mm in inside diameter, and contains the radioactive sources. Localization of the target volume is determined by the preoperative findings of computed tomography (CT), magnetic resonance imaging (MRI), and cerebral angiography. Dosimetry and dose planning are so finalized for the target volume as to be irradiated interstitially more than tumoricidal dose. After stereotactic biopsy of the deep-seated @entity3 , stereotactic implantation of the outer catheters is performed using Iseki Stereotactic System in the CT room. Burr holes had been previously opened in the operating room. The inner catheters containing nonradioactive sources (dummy sources) are inserted, and skull X-p is taken to confirm the position of the dummy sources, and to calculate the dosimetry by computer. The inner catheters are replaced with catheters containing radioactive sources (226Ra) in the irradiation room. 226Ra sources deliver at least 500 rads/day (approximately 20 rads/hr) to the target volume as interstitial irradiation. Two @entity0 of @entity1 treated with this procedure were shown as representative cases. These @entity0 underwent CT-guided stereotactic brachytherapy as "boost" combined with conventional external irradiation.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [CT-guided stereotactic brachytherapy in deep-seated XXXX --interstitial irradiation by double-catheter after-loading method].

answer: @entity1


abstract: OBJECTIVE: To investigate the differentiation potential of @entity0 adipose tissue-derived cells (ADSCs) into neuron-like cells in vitro using a two-step induction protocol. METHODS: ADSCs isolated from the epididymal fat pads in male SD @entity0 by means of differential attachment were cultured in vitro and subjected to adipogenic induction. After flow cytometric identification of the cell surface antigens CD106, @entity9 , @entity2 , CD49d, @entity8 and CD29, the third-passage ADSCs were induced to transdifferentiate into neural stem cell (NSC)-like cells in DMEM/F12 medium containing 10 ng/ml @entity1 ( @entity1 ), 20 ng/ml @entity6 . The resultant NSC-like cells were then induced to differentiate into neuron-like cells in the neurobasal medium containing 10 ng/ml @entity4 ( @entity4 ), 10 ng/ml @entity7 ( @entity7 ) and 1   mol/L @entity3 (RA). Immunocytochemistry was employed to identify the expression of the cell surface markers nestin, @entity10 and @entity5 . RESULTS: The isolated ADSCs were positive for @entity8 and CD29, and oil red O staining of the induced adipose-like cells yielded positive results. The third-passage ADSCs induced for 7 days aggregated as floating cell spheres positive for NSC surface antigen nestin. Further induction in neurobasal medium for 4 h resulted in adhesion of the cell spheres and the formation of cell processes extending from some peripheral cells, suggesting a morphological resemblance to neurons. Most of the cells showed positivity for @entity10 and @entity5 . CONCLUSION: ADSCs can be induced to differentiate into neuron-like cells in vitro under appropriate conditions.

title: [A two-step protocol for induction of XXXX adipose tissue-derived stem cells into neuron-like cells].

answer: @entity0


abstract: AIMS: @entity1 ( @entity1 ) ablation still requires long procedural time and high radiation exposure with its related risk for the @entity0 and the operators. This study was designed to compare three different approaches of @entity1 ablation to verify the hypothesis that image integration with electroanatomic mapping allows minimal use of fluoroscopy. Therefore, we evaluated the procedure and fluoroscopy times of ablation using three imaging modalities: conventional fluoroscopy, image integration electroanatomic mapping, and a new electroanatomic mapping system that provides visualization of multiple catheters. METHODS AND RESULTS: One hundred and twenty @entity0 with symptomatic refractory @entity1 were enrolled in the study. @entity0 were randomly assigned to fluoroscopy alone (Group A, 40 @entity0 ), electroanatomic integration (Cartomerge  , Group B, 40 @entity0 ), and electroanatomic integration plus catheters visualization (Carto   3 System, Group C, 40 @entity0 ) guided procedures. The ablation procedure aimed at isolating the pulmonary veins and creating lesion lines at the left atrial roof and left isthmus. Procedure and fluoroscopy parameters were recorded in all @entity0 . Total procedure time and skin to catheter positioning time did not significantly differ between the groups. Total fluoroscopy time was statistically different between all three groups (Group A, 18'09     5'00   ; Group B, 9'48     3'41   ; Group C, 2'28     1'40   ; P<0.001). A significant difference was noted in ablation fluoroscopy time between all groups (P<0.001), mainly due to shortened fluoroscopy time in Group B (7'34     3'15   ) and Group C (0'21     0'31   ) when compared with Group A (16'07     5'04   ). CONCLUSION: Image integration and, to a larger extent, visualization of multiple catheters allowed a minimal use of fluoroscopy in transcatheter @entity1 ablation.

title: Visualization of multiple catheters with electroanatomical mapping reduces X-ray exposure during XXXX ablation.

answer: @entity1