abstract: UNASSIGNED: We have established a pair of animal models (J3T-1 and J3T-2) with different invasive and angiogenic phenotypes, and demonstrated that @entity7 is expressed at higher levels in @entity0 T-1 than @entity0 T-2 cells. The function of @entity7 in relation to angiogenesis and invasion was investigated using these models. Stable silencing or overexpression of @entity7 in @entity0 T-1 and @entity0 T-2 cells ( @entity0 T-1shA and @entity0 T-2A cells) was established and used. Thirty @entity0 @entity5 samples were evaluated for expression of @entity7 , @entity3 ( @entity3 ) and platelet-derived growth factor (PDGF). Immunohistochemical and quantitative reverse-transcription polymerase chain reaction analyses revealed higher expression of @entity7 , @entity3 and PDGF in @entity0 T-1 and @entity0 T-2A cells. Cultured @entity0 T-1 and @entity0 T-2A cells exhibited higher adhesive ability to endothelial cells. Histopathological analysis of animal @entity6 revealed that J3T-1 and J3T-2A @entity2 displayed marked angiogenesis and invasion along the neovasculature, whereas J3T-2 and J3T-1shA @entity2 exhibited diffuse, infiltrative invasion without angiogenesis. Positive expression of @entity7 was observed in @entity2 cells surrounding dilated vessels in 25/30 @entity0 @entity5 specimens. Our results reveal that the phenotype of @entity1 is closely related to angiogenesis. We identify @entity7 as a factor regulating angiogenesis and invasion of @entity4 .

title: XXXX regulates angiogenesis and invasion phenotypes of @entity4 .

answer: @entity7


abstract: UNASSIGNED: We have established a pair of animal models (J3T-1 and J3T-2) with different invasive and angiogenic phenotypes, and demonstrated that @entity7 is expressed at higher levels in @entity0 T-1 than @entity0 T-2 cells. The function of @entity7 in relation to angiogenesis and invasion was investigated using these models. Stable silencing or overexpression of @entity7 in @entity0 T-1 and @entity0 T-2 cells ( @entity0 T-1shA and @entity0 T-2A cells) was established and used. Thirty @entity0 @entity5 samples were evaluated for expression of @entity7 , @entity3 ( @entity3 ) and platelet-derived growth factor (PDGF). Immunohistochemical and quantitative reverse-transcription polymerase chain reaction analyses revealed higher expression of @entity7 , @entity3 and PDGF in @entity0 T-1 and @entity0 T-2A cells. Cultured @entity0 T-1 and @entity0 T-2A cells exhibited higher adhesive ability to endothelial cells. Histopathological analysis of animal @entity6 revealed that J3T-1 and J3T-2A @entity2 displayed marked angiogenesis and invasion along the neovasculature, whereas J3T-2 and J3T-1shA @entity2 exhibited diffuse, infiltrative invasion without angiogenesis. Positive expression of @entity7 was observed in @entity2 cells surrounding dilated vessels in 25/30 @entity0 @entity5 specimens. Our results reveal that the phenotype of @entity1 is closely related to angiogenesis. We identify @entity7 as a factor regulating angiogenesis and invasion of @entity4 .

title: @entity7 regulates angiogenesis and invasion phenotypes of XXXX .

answer: @entity4


abstract: Forty-one @entity4 occurred among 1,090 @entity0 with the clinical diagnosis of @entity8 between 1960 and 1977. Thirteen @entity0 died of causes unrelated to @entity8 , whereas @entity4 was related to @entity8 in 28 @entity0 (68%). The most prevalent lesion leading to @entity4 was advanced @entity6 (22/28 @entity0 or 78%) with various late complications: @entity3 , gram-negative @entity1 , @entity7 . The average clinical course among these 22 @entity0 was 10 years from the onset of the disease. The average age at @entity4 was 39 years. @entity0 who died of central nervous system and @entity5 were younger, and their clinical course was shorter. Subclinical @entity8 does not seem to affect life span. Autopsy in 25 @entity0 showed @entity2 in all, including asymptomatic @entity0 and those presenting with clinical manifestations limited to the CNS and the heart. The discrepancy implies difficulty in making the diagnosis, and suggests the need of intensive diagnostic work-up. Improved medical therapy, particularly the control of infections and management of @entity3 , has resulted in a protracted clinical course and a changing pattern of the causes of @entity4 in @entity8 .

title: Mortality in XXXX . A changing pattern of the causes of @entity4 .

answer: @entity8


abstract: Forty-one @entity4 occurred among 1,090 @entity0 with the clinical diagnosis of @entity8 between 1960 and 1977. Thirteen @entity0 died of causes unrelated to @entity8 , whereas @entity4 was related to @entity8 in 28 @entity0 (68%). The most prevalent lesion leading to @entity4 was advanced @entity6 (22/28 @entity0 or 78%) with various late complications: @entity3 , gram-negative @entity1 , @entity7 . The average clinical course among these 22 @entity0 was 10 years from the onset of the disease. The average age at @entity4 was 39 years. @entity0 who died of central nervous system and @entity5 were younger, and their clinical course was shorter. Subclinical @entity8 does not seem to affect life span. Autopsy in 25 @entity0 showed @entity2 in all, including asymptomatic @entity0 and those presenting with clinical manifestations limited to the CNS and the heart. The discrepancy implies difficulty in making the diagnosis, and suggests the need of intensive diagnostic work-up. Improved medical therapy, particularly the control of infections and management of @entity3 , has resulted in a protracted clinical course and a changing pattern of the causes of @entity4 in @entity8 .

title: Mortality in @entity8 . A changing pattern of the causes of XXXX .

answer: @entity4


abstract: Our previous work reported functional recovery after transplantation of @entity3 and @entity0 induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) into rodent models of @entity6 ( @entity6 ). Although hiPSC-NS/PCs proved useful for the treatment of @entity6 , the tumorigenicity of the transplanted cells must be resolved before they can be used in clinical applications. The current study sought to determine the feasibility of ablation of the @entity1 formed after hiPSC-NS/PC transplantation through immunoregulation. Tumorigenic hiPSC-NS/PCs were transplanted into the intact spinal cords of immunocompetent BALB/cA @entity3 with or without immunosuppressant treatment. In vivo bioluminescence imaging was used to evaluate the chronological survival and growth of the transplanted cells. The graft survival rate was 0% in the group without immunosuppressants versus 100% in the group with immunosuppressants. Most of the @entity3 that received immunosuppressants exhibited hind-limb @entity5 owing to @entity1 growth at 3 months after iPSC-NS/PC transplantation. Histological analysis showed that the @entity1 shared certain characteristics with low-grade @entity2 rather than with @entity4 . After confirming the progression of the @entity1 in immunosuppressed @entity3 , the immunosuppressant agents were discontinued, resulting in the complete rejection of iPSC-NS/PC-derived masses within 42 days after drug cessation. In accordance with the @entity1 rejection, hind-limb motor function was recovered in all of the @entity3 . Moreover, infiltration of microglia and lymphocytes was observed during the course of @entity1 rejection, along with apoptosis of iPSC-NS/PC-generated cells. Thus, immune rejection can be used as a fail-safe system against potential tumorigenicity after transplantation of iPSC-NS/PCs to treat @entity6 .

title: Controlling Immune Rejection Is a Fail-Safe System against Potential Tumorigenicity after XXXX iPSC-Derived Neural Stem Cell Transplantation.

answer: @entity0


abstract: UNASSIGNED: For @entity1 ( @entity1 ) @entity0 at stage IB, adjuvant chemotherapy does not improve survival. Evidence suggests that dendritic cell (DC)-activated cytokine-induced killer (DC-CIK) cell therapy in addition to chemotherapy improves survival for stage I-IIIA @entity1 @entity0 after surgery, but there are not enough data to confirm this benefit specifically for those at stage IB. Herein, we retrospectively evaluated the efficacy and safety of this therapy administered to stage IB @entity1 @entity0 . Sixty-six @entity0 were treated with four-cycle adjuvant chemotherapy initiated 3 weeks after surgical resection. In addition, 28 of these @entity0 underwent DC-CIK therapy on a trimonthly basis (average 3.1 times, range 1-6) beginning 1 month after chemotherapy. The disease-free survival (DFS) rates of the two groups were statistically similar, although @entity0 who received DC-CIK therapy showed slightly higher 1- and 2-year DFS rates (100.0% and 96.4%, respectively, compared with 81.6% and 76.3%). More importantly, @entity0 in the DC-CIK therapy group had significantly longer overall survival (p   =   0.018). For @entity0 who received treatment after recurrence, the DC-CIK therapy group had longer progression-free survival compared with the chemotherapy-only group. In addition, @entity0 given DC-CIK therapy experienced less @entity3 and @entity2 . The rate of adverse side effects was similar between the two groups. In conclusion, for these stage IB @entity1 @entity0 , DC-CIK therapy significantly improved 2-year DFS rates compared with those who received chemotherapy only. DC-CIK therapy also benefited @entity0 ' quality of life, and adverse events were acceptable.

title: Adjuvant Chemotherapy With Sequential Cytokine-Induced Killer (CIK) Cells in Stage IB XXXX .

answer: @entity1


abstract: BACKGROUND: @entity3 leads to an increased lifetime risk for end-organ damage due to @entity2 . Guidelines recommend that genetic testing be performed in @entity0 with clinical suspicion of @entity2 accompanied by elevated serum ferritin and @entity1 saturation levels. OBJECTIVE: To evaluate guideline adherence and the clinical and economic impact of @entity4 genetic testing. METHODS: The electronic charts of @entity0 submitted for @entity4 testing in 2012 were reviewed for genetic testing results, biochemical markers of @entity2 and clinical history of phlebotomy. RESULTS: A total of 664 samples were sent for testing, with clinical, biochemical and phlebotomy data available for 160 @entity0 . A positive @entity5 homozygote or @entity6 compound heterozygote test result was observed in 18% of @entity0 . @entity0 with an at-risk @entity4 genotype had significantly higher iron saturation, serum iron and hemoglobin (P<0.001), without higher ferritin or liver enzyme levels. Fifty percent of @entity0 referred for testing did not have biochemical evidence of @entity2 ( @entity1 saturation >45% and ferritin level >300  g   L). @entity0 were four times more likely to undergo phlebotomy if they were gene test positive (RR 4.29 [95% CI 2.35 to 7.83]; P<0.00001). DISCUSSION: One-half of @entity0 referred for testing did not exhibit biochemical evidence of @entity2 . Many @entity0 with biochemical evidence of @entity2 , but with negative genetic test results, did not undergo phlebotomy. A requisition to determine clinical indication for testing may reduce the use of the @entity4 genetic test. Finally, improvement of current genetic test characteristics would improve rationale for the test. CONCLUSION: A significant proportion of @entity3 genetic testing does not adhere to current guidelines and would not alter @entity0 management.

title: Examining the clinical use of XXXX genetic testing.

answer: @entity3


abstract: Intestinal adaptation after extensive small bowel resection results in @entity3 and an increased capacity of the remaining small intestine to absorb solutes and water. We tested the ability of the adapted @entity0 ileum to respond to a secretory stimulus, cholera toxin. Six weeks after 50% jejunal resection (short gut) or sham operation water and solute transport were measured in a 16 cm segment of ileum before and after exposure to cholera toxin in a single pass in vivo perfusion system. During the control periods absorption of @entity1 , @entity2 and water per unit length of intestine was significantly greater in short gut animals (P less than 0.05 to 0.001). After exposure to cholera toxin absorption of @entity1 and @entity2 was significantly reduced in both groups (P less than 0.05 to 0.01). @entity4 and @entity5 secretion and net change in water movement in response to cholera toxin were significantly greater (P less than 0.05 to 0.01) in short gut animals. Generally the differences between short gut and sham operation animals disappeared when the data were normalised for mucosal weight. @entity5 secretion per gram mucosa was less in short gut animals (P less than 0.001). The data indicate that the adapted small bowel is not only capable of enhanced absorption but also of enhanced net secretion in response to cholera toxin. The changes reflect the increased number of enterocytes per unit length of intestine after intestinal adaptation.

title: Effect of cholera toxin on ileal water and solute transport after resection of the proximal small intestine in the XXXX .

answer: @entity0


abstract: Tooth extraction is a routine surgical procedure in dental treatment. As a wound healing process after tooth extraction, a saddle-shaped residual ridge forms due to bone formation in the extraction socket and localized bone resorption on the external surface of the jawbone. The residual ridge is subjected to continuous bone resorption with substantial differences among individuals. In some cases, it results in excessive @entity3 , which complicates dental restorative treatment. This unique oral wound healing process may be influenced by factors that are specific to oral tissue. HIF expression is different in oral wound healing compared to that of @entity2 . The objective of this study was to examine a genetic association between SNP of the @entity4 gene, which is known to have high genetic diversity, and the residual ridge resorption (RRR). Two hundred and two Korean subjects (70.80          9.40 years) with partially or completely edentulous mandible were recruited, and edentulous mandibular bone height was measured following the protocol of the American College of Prosthodontists. The @entity4 allele was directly sequenced in 24 subjects resulting in the variants over 5% frequency in 95% likelihood, whereas tag-SNPs were selected to perform analysis for the remaining population. Student's t-test and ANOVA were used for statistical analysis to examine the association between the SNPs and the RRR. Four novel variants were discovered, and a minor allele of @entity5 was associated with the RRR of the subjects (p = 0.028). @entity5 increases @entity4 transactivity, enhancing angiogenesis and increasing new vessel formation. Thus, @entity5 may play an important role in the disturbed bone remodeling balance resulting in RRR. Results of this study may be useful in developing novel genetic diagnostic tests and identifying Koreans susceptible to developing @entity1 after dental extraction. Most importantly, early screening using genetic information will rescue susceptible @entity0 from the vulnerable situation of @entity1 where no effective prosthetic treatment is available.

title: Single nucleotide polymorphisms in XXXX gene and residual ridge resorption (RRR) of mandible in Korean population.

answer: @entity4


abstract: PURPOSE: To evaluate the safety and efficacy of @entity5 ( @entity5 ) in @entity0 with submassive @entity4 ( @entity4 ). MATERIALS AND METHODS: This retrospective study comprised 45 consecutive @entity0 (15 prospective, 30 retrospective) who underwent @entity5 for submassive @entity4 from June 2012-May 2014. Inclusion criteria were @entity1 ( @entity1 ) as indicated by right ventricle-to-left ventricle (RV:LV) ratio > 0.9, symptoms of < 2 weeks' duration, and absence of absolute contraindication to thrombolysis. All @entity0 underwent pulmonary artery catheterization with a standardized protocol (24 mg recombinant tissue plasminogen activator). Hemodynamic evaluation immediately after @entity5 , RV:LV ratio evaluation at 48-72 hours after @entity5 by computed tomography angiography and echocardiography, and adverse event reporting for a minimum of 30 days were performed. Outcomes and complications are reported as per the Society of Interventional Radiology Reporting Standards for Endovascular Treatment of @entity4 . RESULTS: @entity5 was technically successful in 100% (n = 45) of @entity0 . Main pulmonary artery pressure significantly decreased from 49.8 mm Hg to 31.1 mm Hg (P < .0001). @entity1 significantly improved with mean RV:LV ratios decreasing from 1.59 to 0.93 (P < .0001). There were 6 complications: 4 minor @entity3 episodes at access sites and 2 major @entity3 complications (flank and arm @entity6 ). All-cause mortality at 30 days was 0%. There were no readmissions for @entity4 at 30 days after discharge. CONCLUSIONS: Ultrasound-accelerated catheter-directed thrombolysis using a standardized low-dose protocol is a safe and efficacious method of treatment of submassive @entity4 to reduce @entity2 and @entity1 .

title: Ultrasound-Accelerated Catheter-Directed Thrombolysis for Acute XXXX .

answer: @entity4


abstract: UNASSIGNED: Refractory mesial @entity7 (mTLE) is a debilitating condition potentially amenable to resective surgery. However, between 40 and 50% @entity0 continue to experience @entity6 . The development of imaging prognostic markers of postoperative @entity6 outcome is a crucial objective for @entity5 research. In the present study, we performed analyses of preoperative cortical thickness and subcortical surface shape on MRI in 115 of @entity0 with mTLE and radiologically defined @entity3 being considered for surgery, and 80 healthy controls. @entity0 with excellent (International League Against @entity5 outcome (ILAE) I) and suboptimal (ILAE II-VI) postoperative outcomes had a comparable distribution of preoperative @entity1 . Conventional volumetry of whole hippocampal and extrahippocampal @entity2 , could not differentiate between @entity0 outcome groups. However, surface shape analysis revealed localized atrophy of the thalamus bilaterally and of the posterior/lateral hippocampus contralateral to intended resection in @entity0 with persistent @entity6 relative to those rendered @entity6 free. Data uncorrected for multiple comparisons also revealed @entity4 of the ipsilateral hippocampus posterior to the margins of resection in @entity0 with persistent @entity6 . This data indicates that persistent @entity6 after temporal lobe surgery are related to localized preoperative shape alterations of the thalamus bilaterally and the hippocampus contralateral to intended resection. Imaging techniques that have the potential to unlock prognostic markers of postoperative outcome in individual @entity0 should focus assessment on a bihemispheric thalamohippocampal network in prospective @entity0 with refractory mTLE being considered for temporal lobe surgery. Hum Brain Mapp, 2014.    2014 The Authors @entity0 Brain Mapping Published by Wiley Periodicals, Inc.

title: Morphometric MRI alterations and postoperative XXXX control in refractory @entity7 .

answer: @entity6


abstract: UNASSIGNED: Refractory mesial @entity7 (mTLE) is a debilitating condition potentially amenable to resective surgery. However, between 40 and 50% @entity0 continue to experience @entity6 . The development of imaging prognostic markers of postoperative @entity6 outcome is a crucial objective for @entity5 research. In the present study, we performed analyses of preoperative cortical thickness and subcortical surface shape on MRI in 115 of @entity0 with mTLE and radiologically defined @entity3 being considered for surgery, and 80 healthy controls. @entity0 with excellent (International League Against @entity5 outcome (ILAE) I) and suboptimal (ILAE II-VI) postoperative outcomes had a comparable distribution of preoperative @entity1 . Conventional volumetry of whole hippocampal and extrahippocampal @entity2 , could not differentiate between @entity0 outcome groups. However, surface shape analysis revealed localized atrophy of the thalamus bilaterally and of the posterior/lateral hippocampus contralateral to intended resection in @entity0 with persistent @entity6 relative to those rendered @entity6 free. Data uncorrected for multiple comparisons also revealed @entity4 of the ipsilateral hippocampus posterior to the margins of resection in @entity0 with persistent @entity6 . This data indicates that persistent @entity6 after temporal lobe surgery are related to localized preoperative shape alterations of the thalamus bilaterally and the hippocampus contralateral to intended resection. Imaging techniques that have the potential to unlock prognostic markers of postoperative outcome in individual @entity0 should focus assessment on a bihemispheric thalamohippocampal network in prospective @entity0 with refractory mTLE being considered for temporal lobe surgery. Hum Brain Mapp, 2014.    2014 The Authors @entity0 Brain Mapping Published by Wiley Periodicals, Inc.

title: Morphometric MRI alterations and postoperative @entity6 control in refractory XXXX .

answer: @entity7


abstract: BACKGROUND: Enthusiasm for endovascular therapies has led to the use of stent graft repairs for popliteal artery @entity2 . In this report, we review our experience with this technique. METHODS: A retrospective review was performed of all @entity1 repairs (EVPARs) performed by the vascular surgery group at a tertiary care medical center. @entity0 demographic data, operative details, and outcomes were examined. RESULTS: We performed 33 EVPARs in 28 @entity0 . All @entity0 were male with a mean age of 76  years (range, 60-91). Mean @entity2 diameter was 3.2  cm (range, 1.5-6.3). All repairs were performed using a self-expanding covered stent graft. Among the @entity0 , 18% were symptomatic at the time of repair. The median number of stents used was 2 (range, 1-4). Median duration of stay was 1  day (range, 0-12). The 1-year and 2-year patency were 87% and 81%, respectively, with a mean follow-up of 23  months. Loss of patency was associated with both poor distal runoff (P  =  .007) and increasing number of stents used (P  =  .03). Early complications were seen in 4 @entity0 including: stent oversizing leading to in-folding, perforation of a tibial artery, access site @entity3 , and access vessel dissection. CONCLUSION: As experience with EVPAR continues to grow, caution must be applied in its use. Careful @entity0 selection, proper operative technique, and correct vessel sizing are required for good outcomes. Poor distal runoff and use of numerous stents leads to diminished patency rates.

title: Mid-term outcomes of self-expanding covered stent grafts for repair of popliteal artery XXXX .

answer: @entity2


abstract: Six @entity0 with @entity2 had colonic intraluminal multilobulated masses detected on barium enema. Four had @entity2 and two @entity2 . The mean duration of disease was four and eight tenths years. Three @entity0 underwent surgery and three had colonoscopy with multiple biopsies and cytology. Pseudopolypoid inflammatory tissue was found in each case. One @entity0 died after a prolonged postoperative course due to @entity4 and @entity5 formation. No surgery was performed in three @entity0 and follow-up colonoscopic examinations at four and a half years revealed no change in these findings. The presence of an intraluminal colonic mass in @entity2 may mimic a @entity1 . If surveillance with x-ray, endoscopic biopsies and cytology reveals pseudopolypoid inflammatory tissue then surgery is not mandatory. Pseudopolypoid inflammatory tissue has never been associated with @entity3 .

title: Giant pseudopolyps in XXXX . A nonoperative approach.

answer: @entity2


abstract: PURPOSE: We aimed to determine the predictors of technical success and patency after percutaneous transluminal angioplasty (PTA) of de novo dysfunctional hemodialysis @entity3 ( @entity3 ). METHODS: We performed a retrospective analysis of first time PTA in 228 @entity0 (129 @entity0 , 99 @entity0 ; mean age, 56.8  14.6 years). Anatomical (location, length, grade, and number of stenoses) and clinical variables (sex, age, prior @entity3 , @entity1 , @entity3 age, side, and location) were reviewed. RESULTS: A total of 330 stenoses were found in 228 @entity0 . PTA was technically successful in 96.3% of the stenoses (n=319). Clinical success was achieved in 97.2% (n=321). Early dysfunction (within six months) was positively correlated with @entity0 age (P < 0.001) and @entity1 (P < 0.005). Older age (P < 0.001) and @entity1 (P = 0.002) were associated with a lower primary patency rate. @entity0 age (P %lt; 0.001), presence of @entity1 (P = 0.023), length of @entity2 (P = 0.003), early recurrence (P = 0.003) and presence of residual @entity2 (P = 0.014) were associated with a lower secondary patency rate. CONCLUSION: Patency of dysfunctional hemodialysis fistulas can be maintained safely with continuous follow-up and repeated interventions without shortening the venous segment by surgical revision. Percutaneous approach to hemodialysis access @entity2 is an alternative to the conventional surgical approach and PTA is an effective treatment method for dysfunctional @entity3 .

title: Percutaneous transluminal balloon angioplasty in @entity2 of native hemodialysis XXXX : technical success and analysis of factors affecting postprocedural fistula patency.

answer: @entity3


abstract: PURPOSE: We aimed to determine the predictors of technical success and patency after percutaneous transluminal angioplasty (PTA) of de novo dysfunctional hemodialysis @entity3 ( @entity3 ). METHODS: We performed a retrospective analysis of first time PTA in 228 @entity0 (129 @entity0 , 99 @entity0 ; mean age, 56.8  14.6 years). Anatomical (location, length, grade, and number of stenoses) and clinical variables (sex, age, prior @entity3 , @entity1 , @entity3 age, side, and location) were reviewed. RESULTS: A total of 330 stenoses were found in 228 @entity0 . PTA was technically successful in 96.3% of the stenoses (n=319). Clinical success was achieved in 97.2% (n=321). Early dysfunction (within six months) was positively correlated with @entity0 age (P < 0.001) and @entity1 (P < 0.005). Older age (P < 0.001) and @entity1 (P = 0.002) were associated with a lower primary patency rate. @entity0 age (P %lt; 0.001), presence of @entity1 (P = 0.023), length of @entity2 (P = 0.003), early recurrence (P = 0.003) and presence of residual @entity2 (P = 0.014) were associated with a lower secondary patency rate. CONCLUSION: Patency of dysfunctional hemodialysis fistulas can be maintained safely with continuous follow-up and repeated interventions without shortening the venous segment by surgical revision. Percutaneous approach to hemodialysis access @entity2 is an alternative to the conventional surgical approach and PTA is an effective treatment method for dysfunctional @entity3 .

title: Percutaneous transluminal balloon angioplasty in XXXX of native hemodialysis @entity3 : technical success and analysis of factors affecting postprocedural fistula patency.

answer: @entity2


abstract: BACKGROUND: It is unclear why @entity4 -IgG primarily causes central nervous system lesions by activating complement, but generally spares peripheral @entity4 -expressing organs. OBJECTIVES: To determine whether peripheral @entity4 -expressing cells are protected from complement-mediated damage by expressing complement regulators. METHODS: @entity0 tissue and cultured @entity0 cells were immunostained for @entity4 ( @entity4 ), @entity1 , @entity5 and @entity2 . We also determined the vulnerability to @entity4 -IgG and complement-mediated damage of astrocytes cultured alone or co-cultured with endothelial cells. RESULTS: In normal brain, astrocyte end-feet express @entity4 , but are devoid of @entity1 , @entity5 and @entity2 . Immunoreactivity for @entity1 , @entity5 and @entity2 is not increased in or around @entity3 lesions. In kidney @entity4 is co-expressed with @entity1 and @entity5 , in stomach @entity4 is co-expressed with @entity1 and in skeletal muscle @entity4 is co-expressed with @entity1 . Astrocytes cultured alone co-express @entity4 and @entity2 but, in astrocyte-endothelial co-cultures, @entity4 is found in cell processes devoid of @entity2 . Astrocytes co-cultured with endothelial cells are more vulnerable to @entity4 -IgG and complement-mediated lysis than astrocytes cultured alone. CONCLUSIONS: Complement regulators protect peripheral organs, but not the central nervous system, from @entity4 -IgG and complement-mediated damage. Our findings may explain why @entity3 primarily damages the central nervous system, but spares peripheral organs.

title: Role of membrane complement regulators in XXXX .

answer: @entity3


abstract: BACKGROUND: @entity1 after cardiac surgery can be caused by impaired platelet (PLT) function after cardiopulmonary bypass. Desmopressin or @entity4 ( @entity4 ) is a synthetic analog of vasopressin. @entity4 can increase the level of @entity3 factor VIII, thus it may enhance PLT function and improve coagulation. In this study, we assessed the effects of @entity4 on @entity2 and @entity1 in @entity0 undergoing cardiac surgery. METHODS: A total of 102 @entity0 undergoing valvular heart surgery (from October 2010 to June 2011) were divided into @entity4 group (n = 52) and control group (n = 50). A dose of @entity4 (0.3  g/kg) was administered to the @entity0 intravenously when they were being re-warmed. At the same time, an equal volume of saline was given to the @entity0 in the control group. @entity2 rate was measured with the AggRAM four-way @entity2 measurement instrument. The @entity1 and transfusion, hemoglobin levels, PLT counts, and urine outputs at different time were recorded and compared. RESULTS: The postoperative @entity1 in the first 6 h was significantly reduced in @entity4 group (202    119 ml vs. 258    143 ml, P = 0.023). The incidence of fresh frozen plasma (FFP) transfusion was decreased postoperatively in @entity4 group (3.8% vs. 12%, P = 0.015). There was no significant difference in the @entity2 , urine volumes, red blood cell transfusions and @entity1 after 24 h between two groups. CONCLUSIONS: A single dose of @entity4 can reduce the first 6 h @entity1 and FFP transfusion postoperatively in @entity0 undergoing valvular heart surgery, but has no effect on @entity2 .

title: Effect of desmopressin on XXXX and @entity1 in @entity0 undergoing valvular heart surgery.

answer: @entity2


abstract: BACKGROUND: @entity1 after cardiac surgery can be caused by impaired platelet (PLT) function after cardiopulmonary bypass. Desmopressin or @entity4 ( @entity4 ) is a synthetic analog of vasopressin. @entity4 can increase the level of @entity3 factor VIII, thus it may enhance PLT function and improve coagulation. In this study, we assessed the effects of @entity4 on @entity2 and @entity1 in @entity0 undergoing cardiac surgery. METHODS: A total of 102 @entity0 undergoing valvular heart surgery (from October 2010 to June 2011) were divided into @entity4 group (n = 52) and control group (n = 50). A dose of @entity4 (0.3  g/kg) was administered to the @entity0 intravenously when they were being re-warmed. At the same time, an equal volume of saline was given to the @entity0 in the control group. @entity2 rate was measured with the AggRAM four-way @entity2 measurement instrument. The @entity1 and transfusion, hemoglobin levels, PLT counts, and urine outputs at different time were recorded and compared. RESULTS: The postoperative @entity1 in the first 6 h was significantly reduced in @entity4 group (202    119 ml vs. 258    143 ml, P = 0.023). The incidence of fresh frozen plasma (FFP) transfusion was decreased postoperatively in @entity4 group (3.8% vs. 12%, P = 0.015). There was no significant difference in the @entity2 , urine volumes, red blood cell transfusions and @entity1 after 24 h between two groups. CONCLUSIONS: A single dose of @entity4 can reduce the first 6 h @entity1 and FFP transfusion postoperatively in @entity0 undergoing valvular heart surgery, but has no effect on @entity2 .

title: Effect of desmopressin on @entity2 and XXXX in @entity0 undergoing valvular heart surgery.

answer: @entity1


abstract: BACKGROUND: @entity1 after cardiac surgery can be caused by impaired platelet (PLT) function after cardiopulmonary bypass. Desmopressin or @entity4 ( @entity4 ) is a synthetic analog of vasopressin. @entity4 can increase the level of @entity3 factor VIII, thus it may enhance PLT function and improve coagulation. In this study, we assessed the effects of @entity4 on @entity2 and @entity1 in @entity0 undergoing cardiac surgery. METHODS: A total of 102 @entity0 undergoing valvular heart surgery (from October 2010 to June 2011) were divided into @entity4 group (n = 52) and control group (n = 50). A dose of @entity4 (0.3  g/kg) was administered to the @entity0 intravenously when they were being re-warmed. At the same time, an equal volume of saline was given to the @entity0 in the control group. @entity2 rate was measured with the AggRAM four-way @entity2 measurement instrument. The @entity1 and transfusion, hemoglobin levels, PLT counts, and urine outputs at different time were recorded and compared. RESULTS: The postoperative @entity1 in the first 6 h was significantly reduced in @entity4 group (202    119 ml vs. 258    143 ml, P = 0.023). The incidence of fresh frozen plasma (FFP) transfusion was decreased postoperatively in @entity4 group (3.8% vs. 12%, P = 0.015). There was no significant difference in the @entity2 , urine volumes, red blood cell transfusions and @entity1 after 24 h between two groups. CONCLUSIONS: A single dose of @entity4 can reduce the first 6 h @entity1 and FFP transfusion postoperatively in @entity0 undergoing valvular heart surgery, but has no effect on @entity2 .

title: Effect of desmopressin on @entity2 and @entity1 in XXXX undergoing valvular heart surgery.

answer: @entity0


abstract: The effects of @entity4 (AS) on the mechanical function, tissue @entity3 content, and tissue @entity2 content were studied in the isolated, arterially perfused newborn and adult @entity0 septum. Newborn and adult muscles were perfused with Krebs-Henseleit solutions containing 0.25, 0.5, 1.0, 1.5, 2.5, or 5.0 X 10(-6) M AS. 42K and 47Ca were used in the measurement of tissue uptakes of these ions. The inotropic effect of AS in the newborn was equal to that in the adult for AS concentrations less than 1.0 X 10(-6) M but was greater (P less than 0.01) than that in the adult at higher concentrations. In muscles perfused with solutions containing AS concentrations higher than 0.5 X 10(-6) M in the adult and 1 X 10(-6) M in the newborn, contractility increased initially and then decreased (mechanical @entity1 ). @entity1 in the adult occurred sooner than in the newborn. A decrease in tissue @entity3 and an increase in tissue @entity2 were observed immediately after AS infusion in the two age groups. The rates of tissue @entity3 loss and @entity2 gain in the newborn were not significantly different from those in the adult. @entity1 in the newborn was less than that in the adult for an equal amount of tissue @entity3 loss and/or tissue @entity2 gain. These data indicate that, in the isolated arterially perfused septal preparation, the newborn myocardium tolerates larger concentrations of AS, resulting in a greater inotropic effect which is observed before the onset of @entity1 .

title: Effect of @entity4 on myocardial function and K+ and Ca2+ exchange in newborn XXXX .

answer: @entity0


abstract: The effects of @entity4 (AS) on the mechanical function, tissue @entity3 content, and tissue @entity2 content were studied in the isolated, arterially perfused newborn and adult @entity0 septum. Newborn and adult muscles were perfused with Krebs-Henseleit solutions containing 0.25, 0.5, 1.0, 1.5, 2.5, or 5.0 X 10(-6) M AS. 42K and 47Ca were used in the measurement of tissue uptakes of these ions. The inotropic effect of AS in the newborn was equal to that in the adult for AS concentrations less than 1.0 X 10(-6) M but was greater (P less than 0.01) than that in the adult at higher concentrations. In muscles perfused with solutions containing AS concentrations higher than 0.5 X 10(-6) M in the adult and 1 X 10(-6) M in the newborn, contractility increased initially and then decreased (mechanical @entity1 ). @entity1 in the adult occurred sooner than in the newborn. A decrease in tissue @entity3 and an increase in tissue @entity2 were observed immediately after AS infusion in the two age groups. The rates of tissue @entity3 loss and @entity2 gain in the newborn were not significantly different from those in the adult. @entity1 in the newborn was less than that in the adult for an equal amount of tissue @entity3 loss and/or tissue @entity2 gain. These data indicate that, in the isolated arterially perfused septal preparation, the newborn myocardium tolerates larger concentrations of AS, resulting in a greater inotropic effect which is observed before the onset of @entity1 .

title: Effect of XXXX on myocardial function and K+ and Ca2+ exchange in newborn @entity0 .

answer: @entity4


abstract: OBJECTIVE: We aimed to assess the effects of electronic @entity2 delivery system (ENDS) or also termed electronic cigarette vapor on the laryngeal mucosa of @entity1 . MATERIALS AND METHODS: Sixteen female @entity1 albino @entity1 were divided into two groups. The study group was exposed to ENDS vapor for 1  hour/day for 4  weeks. The control group was not subjected to any chemical or physical stimulus. The vocal folds of the study and control group @entity1 were evaluated histopathologically by @entity4 and @entity5 staining and immunohistochemically by Ki67 staining. Epithelial distribution, @entity0 , @entity3 , and @entity6 were evaluated. RESULTS: Epithelial distribution and @entity0 did not differ between the two groups. Two cases of @entity3 were detected in the study group but there was no @entity3 in the control group. Four cases of @entity6 were detected in the study group and one case in the control group. Statistical analysis revealed no significant difference between the study and control groups (P  =  0.131 and 0.106, respectively). CONCLUSIONS: Exposure to ENDS for 4  weeks caused @entity3 and @entity6 of the laryngeal mucosa of @entity1 but this was not significant statistically. These results implemented that further studies with larger cohort and longer duration are required to evaluate long-term effects.

title: Effects of Electronic XXXX Delivery System on Larynx: Experimental Study.

answer: @entity2


abstract: Recent studies have posited that machine learning (ML) techniques accurately classify individuals with and without @entity2 solely based on neuroimaging data. These studies claim that self-report is unreliable, making "objective" neuroimaging classification methods imperative. However, the relative performance of ML on neuroimaging and self-report data have not been compared. This study used commonly reported ML algorithms to measure differences between "objective" neuroimaging data and "subjective" self-report (ie, mood and @entity2 intensity) in their ability to discriminate between individuals with and without @entity5 . Structural magnetic resonance imaging data from 26 individuals (14 individuals with @entity3 and 12 healthy controls) were processed to derive volumes from 56 brain regions per @entity0 . Self-report data included visual analog scale ratings for @entity2 intensity and mood (ie, anger, @entity1 , @entity4 , frustration, and fear). Separate models representing brain volumes, mood ratings, and @entity2 intensity ratings were estimated across several ML algorithms. Classification accuracy of brain volumes ranged from 53 to 76%, whereas mood and @entity2 intensity ratings ranged from 79 to 96% and 83 to 96%, respectively. Overall, models derived from self-report data outperformed neuroimaging models by an average of 22%. Although neuroimaging clearly provides useful insights for understanding neural mechanisms underlying @entity2 processing, self-report is reliable and accurate and continues to be clinically vital. PERSPECTIVE: The present study compares neuroimaging, self-reported mood, and self-reported @entity2 intensity data in their ability to classify individuals with and without @entity3 using ML algorithms. Overall, models derived from self-reported mood and @entity2 intensity data outperformed structural neuroimaging models.

title: Comparison of machine classification algorithms for XXXX : neuroimages versus self-report.

answer: @entity3


abstract: Ocular and periocular @entity0 are common reasons for emergency department visits. In fact, an estimated 2 million Americans suffer @entity3 each year. Evaluation and treatment of physical and @entity3 and eyelids begin with a systematic examination. Visual acuity and pupillary reaction should be assessed first. Evaluation of the eye should precede examination of the periocular structures due to the potential for causing further damage to a full-thickness @entity3 with manipulation of the eyelids. Physical @entity0 to the eyes and periocular structures include lacerations, abrasions, foreign bodies, and @entity1 and can range from minor irritation to visual devastation. @entity0 can be divided into alkali and acid @entity0 . @entity2 are more common, due to the prevalent use of alkali substances in industrial and home cleaning applications, and usually result in more serious @entity0 . Definitive care of chemical @entity0 ranges from topical antibiotics to full-thickness skin grafts with the goal of preventing cicatricial scarring and exposure of the ocular surface. Familiarity with the various types of ocular and periocular @entity0 is important for all medical professionals and is critical to providing the most appropriate management.

title: Physical and XXXX .

answer: @entity3


abstract: To generate quantitative data relating to the potential @entity0 activity of @entity4 ( @entity3 ), 140 and 560 microunits @entity3 /kg/min were infused chronically in both normotensive @entity1 and @entity1 made @entity0 by chronic infusion of either angiotensin II (AII) or @entity2 . The lower rate of @entity3 infusion increased plasma @entity3 concentration from 0.4 +/- 0.1 microunits/ml. Mean arterial pressure (MAP) was recorded 24 hours per day, and all @entity1 were infused continuously with 800 ml of isotonic saline per day. During the initial days of @entity3 infusion in normotensive @entity1 , natriuresis, kaliuresis, and water retention were prominent and MAP increased progressively to a peak on Day 6 (30 mm Hg above control). Subsequently, diuresis ensued, net water retention decreased, and MAP fell progressively to only 13 mm Hg above control by Day 12 of @entity3 infusion. In contrast, in AII or @entity2 @entity0 @entity1 during @entity3 infusion, the natriuresis was greatly attenuated, water balance was unchanged or even negative, and MAP either did not increase or increased only transiently. When @entity3 infusion was terminated in @entity1 given only @entity3 , diuresis occurred, and MAP fell gradually over a period of hours to @entity0 levels. In marked contrast, cessation of @entity3 infusion in @entity1 with either AII or @entity2 @entity0 was associated with a precipitous fall in MAP of 35 to 40 mm Hg within 1 hour: however, this reduction was only transient - over the subsequent hours, both salt and water retention occurred, and MAP returned to previous @entity0 levels. Thus, in the @entity0 models studied, high plasma levels of @entity3 had relatively weak @entity0 effects. Although variations in plasma @entity3 concentration were associated with rather pronounced acute effects on MAP, the long-term changes in MAP produced by @entity3 were either minimal or, in the case of the animals made @entity0 by other agents, nonexistent.

title: Is vasopressin an important XXXX hormone?

answer: @entity0


abstract: The chemosensitivity of @entity0 @entity4 cells has been studied before and after continuous in vitro culture. Altogether, nine cell lines were studied, two derived from @entity0 ' biopsies, and seven from xenografts in athymic @entity3 . The sensitivity to the agents DTIC ( @entity5 ), @entity9 ( @entity8 ), @entity6 , @entity7 , abrin and ricin was assayed. Furthermore, in five cases the chemosensitivity of the cell lines was compared to that of @entity2 obtained by injecting the cell lines into athymic @entity3 . In all cases the sensitivity was measured in an in vitro soft agar assay. Upon cultivation in vitro, two of the cell lines, one derived from a @entity0 's @entity1 and one from a xenograft in athymic @entity3 , showed marked increases in sensitivity to some of the drugs, whereas sensitivity to other drugs showed little or no change. For the other cell lines small, but definite increases or decreases in chemosensitivity were observed. Permanent cultures showed the same chemosensitivity as early subcultures. The @entity2 formed by injecting the cell lines into athymic @entity3 showed moderate changes in chemosensitivity, as compared to the cell lines in vitro. The data indicate that considerable changes in chemosensitivity may occur when cells are brought from in vitro to in vitro conditions and vice versa and that such changes may be highly specific. Therefore, although cell lines may be useful in some respects, they should be used with caution in attempts to evaluate quantitatively the sensitivity of @entity0 @entity2 to cancerostatic drugs.

title: The usefulness of @entity0 @entity2 cell lines in the study of chemosensitivity. A study of XXXX .

answer: @entity4


abstract: The chemosensitivity of @entity0 @entity4 cells has been studied before and after continuous in vitro culture. Altogether, nine cell lines were studied, two derived from @entity0 ' biopsies, and seven from xenografts in athymic @entity3 . The sensitivity to the agents DTIC ( @entity5 ), @entity9 ( @entity8 ), @entity6 , @entity7 , abrin and ricin was assayed. Furthermore, in five cases the chemosensitivity of the cell lines was compared to that of @entity2 obtained by injecting the cell lines into athymic @entity3 . In all cases the sensitivity was measured in an in vitro soft agar assay. Upon cultivation in vitro, two of the cell lines, one derived from a @entity0 's @entity1 and one from a xenograft in athymic @entity3 , showed marked increases in sensitivity to some of the drugs, whereas sensitivity to other drugs showed little or no change. For the other cell lines small, but definite increases or decreases in chemosensitivity were observed. Permanent cultures showed the same chemosensitivity as early subcultures. The @entity2 formed by injecting the cell lines into athymic @entity3 showed moderate changes in chemosensitivity, as compared to the cell lines in vitro. The data indicate that considerable changes in chemosensitivity may occur when cells are brought from in vitro to in vitro conditions and vice versa and that such changes may be highly specific. Therefore, although cell lines may be useful in some respects, they should be used with caution in attempts to evaluate quantitatively the sensitivity of @entity0 @entity2 to cancerostatic drugs.

title: The usefulness of @entity0 XXXX cell lines in the study of chemosensitivity. A study of @entity4 .

answer: @entity2


abstract: The chemosensitivity of @entity0 @entity4 cells has been studied before and after continuous in vitro culture. Altogether, nine cell lines were studied, two derived from @entity0 ' biopsies, and seven from xenografts in athymic @entity3 . The sensitivity to the agents DTIC ( @entity5 ), @entity9 ( @entity8 ), @entity6 , @entity7 , abrin and ricin was assayed. Furthermore, in five cases the chemosensitivity of the cell lines was compared to that of @entity2 obtained by injecting the cell lines into athymic @entity3 . In all cases the sensitivity was measured in an in vitro soft agar assay. Upon cultivation in vitro, two of the cell lines, one derived from a @entity0 's @entity1 and one from a xenograft in athymic @entity3 , showed marked increases in sensitivity to some of the drugs, whereas sensitivity to other drugs showed little or no change. For the other cell lines small, but definite increases or decreases in chemosensitivity were observed. Permanent cultures showed the same chemosensitivity as early subcultures. The @entity2 formed by injecting the cell lines into athymic @entity3 showed moderate changes in chemosensitivity, as compared to the cell lines in vitro. The data indicate that considerable changes in chemosensitivity may occur when cells are brought from in vitro to in vitro conditions and vice versa and that such changes may be highly specific. Therefore, although cell lines may be useful in some respects, they should be used with caution in attempts to evaluate quantitatively the sensitivity of @entity0 @entity2 to cancerostatic drugs.

title: The usefulness of XXXX @entity2 cell lines in the study of chemosensitivity. A study of @entity4 .

answer: @entity0


abstract: UNASSIGNED: Terminal differentiation of B cells depends on two interconnected survival pathways, elicited by the B-cell receptor (BCR) and the @entity7 ( @entity7 ), respectively. Loss of either signaling pathway arrests B-cell development. Although BCR-dependent survival depends mainly on the activation of the v- @entity3 @entity0 thymoma viral oncogene homolog 1 ( @entity3 )/PI3-kinase network, @entity4 / @entity7 -mediated survival engages non-canonical NF-kB signaling as well as MAPK/extracellular-signal regulated kinase and @entity3 /PI3-kinase modules to allow proper B-cell development. Plasma cell survival, however, is independent of @entity7 and regulated by APRIL that signals NF-kB activation via alternative receptors, that is, @entity8 ( @entity8 ) or B-cell maturation (BCMA). All these complex signaling events are believed to secure survival by increased expression of anti-apoptotic @entity2 ( @entity2 ) family proteins in developing and mature B cells. Curiously, how lack of @entity4 - or APRIL-mediated signaling triggers B-cell apoptosis remains largely unexplored. Here, we show that two pro-apoptotic members of the ' @entity2 homology domain 3-only' subgroup of the @entity2 family, @entity2 interacting mediator of cell death (Bim) and @entity5 (Bmf), mediate apoptosis in the context of @entity8 -Ig overexpression that effectively neutralizes @entity4 as well as APRIL. Surprisingly, although @entity2 overexpression triggers B-cell @entity1 exceeding the one observed in Bim(-/-)Bmf(-/-) @entity0 , @entity2 transgenic B cells remain susceptible to the effects of @entity8 -Ig expression in vivo, leading to ameliorated pathology in @entity6 - @entity2 @entity0 . Together, our findings shed new light on the molecular machinery restricting B-cell survival during development, normal homeostasis and under pathological conditions. Our data further suggest that @entity2 antagonists might improve the potency of @entity4 /APRIL-depletion strategies in B-cell-driven pathologies.Cell Death and Differentiation advance online publication, 20 February 2015; doi:10.1038/cdd.2015.8.

title: Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in XXXX -Ig @entity0 .

answer: @entity8


abstract: UNASSIGNED: Terminal differentiation of B cells depends on two interconnected survival pathways, elicited by the B-cell receptor (BCR) and the @entity7 ( @entity7 ), respectively. Loss of either signaling pathway arrests B-cell development. Although BCR-dependent survival depends mainly on the activation of the v- @entity3 @entity0 thymoma viral oncogene homolog 1 ( @entity3 )/PI3-kinase network, @entity4 / @entity7 -mediated survival engages non-canonical NF-kB signaling as well as MAPK/extracellular-signal regulated kinase and @entity3 /PI3-kinase modules to allow proper B-cell development. Plasma cell survival, however, is independent of @entity7 and regulated by APRIL that signals NF-kB activation via alternative receptors, that is, @entity8 ( @entity8 ) or B-cell maturation (BCMA). All these complex signaling events are believed to secure survival by increased expression of anti-apoptotic @entity2 ( @entity2 ) family proteins in developing and mature B cells. Curiously, how lack of @entity4 - or APRIL-mediated signaling triggers B-cell apoptosis remains largely unexplored. Here, we show that two pro-apoptotic members of the ' @entity2 homology domain 3-only' subgroup of the @entity2 family, @entity2 interacting mediator of cell death (Bim) and @entity5 (Bmf), mediate apoptosis in the context of @entity8 -Ig overexpression that effectively neutralizes @entity4 as well as APRIL. Surprisingly, although @entity2 overexpression triggers B-cell @entity1 exceeding the one observed in Bim(-/-)Bmf(-/-) @entity0 , @entity2 transgenic B cells remain susceptible to the effects of @entity8 -Ig expression in vivo, leading to ameliorated pathology in @entity6 - @entity2 @entity0 . Together, our findings shed new light on the molecular machinery restricting B-cell survival during development, normal homeostasis and under pathological conditions. Our data further suggest that @entity2 antagonists might improve the potency of @entity4 /APRIL-depletion strategies in B-cell-driven pathologies.Cell Death and Differentiation advance online publication, 20 February 2015; doi:10.1038/cdd.2015.8.

title: Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in @entity8 -Ig XXXX .

answer: @entity0


abstract: OBJECTIVES: Surgical treatment of extensive cervicofacial @entity1 is often challenging due to a high rate of postoperative fluid re-accumulation and lesion recurrence resulting from incomplete resection. This study suggests a combined treatment of surgical resection and postoperative adjuvant @entity2 sclerotherapy via closed suction drainage. Using comparative analysis, this study aims to evaluate the efficacy of adjuvant sclerotherapy. METHODS: A retrospective chart review was performed on @entity0 who underwent surgical resection of cervicofacial @entity1 between January 2009 and July 2013. @entity0 were divided into two groups based on whether or not adjuvant @entity2 sclerotherapy was administered via closed suction drainage after surgery. Both surgery-related and adjuvant sclerotherapy-related complications were assessed, and treatment effectiveness was measured based on the change in Cologne Disease Score (CDS) or the need for further treatment. RESULTS: A total of 17 @entity0 underwent surgical resection. Nine of these @entity0 underwent surgical resection only, while the other eight underwent surgical resection with adjuvant @entity2 sclerotherapy. The increase in total Cologne Disease Score (CDS) and change of progression parameters were significantly higher for the adjuvant sclerotherapy group compared to the surgery-only group. Additionally, there were no cases of postoperative lymphatic fluid retention among the adjuvant sclerotherapy group. The two groups exhibited similar complication rates with no statistically significant difference. CONCLUSIONS: Adjuvant @entity2 sclerotherapy via closed suction drainage is a safe and effective treatment modality. The combination of surgical resection and post-operative adjuvant sclerotherapy via closed suction drainage should be integrated into the treatment algorithm of extensive cervicofacial @entity1 .

title: Postoperative adjuvant XXXX sclerotherapy for treatment of cervicofacial @entity1 : An outcomes comparison.

answer: @entity2


abstract: OBJECTIVES: Surgical treatment of extensive cervicofacial @entity1 is often challenging due to a high rate of postoperative fluid re-accumulation and lesion recurrence resulting from incomplete resection. This study suggests a combined treatment of surgical resection and postoperative adjuvant @entity2 sclerotherapy via closed suction drainage. Using comparative analysis, this study aims to evaluate the efficacy of adjuvant sclerotherapy. METHODS: A retrospective chart review was performed on @entity0 who underwent surgical resection of cervicofacial @entity1 between January 2009 and July 2013. @entity0 were divided into two groups based on whether or not adjuvant @entity2 sclerotherapy was administered via closed suction drainage after surgery. Both surgery-related and adjuvant sclerotherapy-related complications were assessed, and treatment effectiveness was measured based on the change in Cologne Disease Score (CDS) or the need for further treatment. RESULTS: A total of 17 @entity0 underwent surgical resection. Nine of these @entity0 underwent surgical resection only, while the other eight underwent surgical resection with adjuvant @entity2 sclerotherapy. The increase in total Cologne Disease Score (CDS) and change of progression parameters were significantly higher for the adjuvant sclerotherapy group compared to the surgery-only group. Additionally, there were no cases of postoperative lymphatic fluid retention among the adjuvant sclerotherapy group. The two groups exhibited similar complication rates with no statistically significant difference. CONCLUSIONS: Adjuvant @entity2 sclerotherapy via closed suction drainage is a safe and effective treatment modality. The combination of surgical resection and post-operative adjuvant sclerotherapy via closed suction drainage should be integrated into the treatment algorithm of extensive cervicofacial @entity1 .

title: Postoperative adjuvant @entity2 sclerotherapy for treatment of cervicofacial XXXX : An outcomes comparison.

answer: @entity1


abstract: A total of 37 thymic @entity0 was studied out of which 29 proved to be of epithelial origin. @entity1 may be accompanied by a minimal, marked or an overwhelming lymphoid reaction, pointing to the degree of the cellular defensive mechanism. According to the findings, two main types of @entity1 with minimal lymphoid reaction (light and dark cell types) can be distinguished. All the 7 light cell thymomas with minimal lymphoid reaction proved to be malignant in their clinical course. @entity1 of light cell origin with marked lymphoid reaction may be clinically benign or malignant. @entity1 with overwhelming lymphoid reaction were clinically benign. The clinical behavior of the dark cell thymomas was benign. The dark cell thymomas could be divided into subgroups with solid, lacunar and spindle cell forms. Three @entity3 were observed. The T cell origin of one of these @entity0 was demonstrated immunologically. All the five cases of @entity2 were morphologically identical to the modular sclerotic form of lymphogranulomatosis.

title: Morphologic and clinico-pathologic features of XXXX .

answer: @entity0


abstract: @entity1 encodes six resistance-nodulation-division (RND) efflux systems which function in antimicrobial resistance, virulence factor production, and intestinal colonization. Among the six RND efflux systems, VexAB exhibited broad substrate specificity and played a predominant role in intrinsic antimicrobial resistance. The VexAB system was encoded in an apparent three gene operon that included vexR; which encodes an uncharacterized TetR family regulator. In this work we examined the role of vexR in vexRAB expression. We found that VexR bound to the vexRAB promoter and vexR deletion resulted in decreased vexRAB expression and increased susceptibility to VexAB antimicrobial substrates. Substrate-dependent induction of vexRAB was dependent on vexR and episomal vexR expression provided a growth advantage in the presence of the VexAB substrate @entity3 . The expression of vexRAB increased, in a vexR-dependent manner, in response to the loss of RND efflux activity. This suggested that VexAB may function to export intracellular metabolites. Support for this hypothesis was provided by data showing that vexRAB was upregulated in several metabolic mutants including @entity2 biosynthetic mutants that were predicted to accumulate @entity0 . In addition, vexRAB was found to be upregulated in response to exogenous @entity0 and to contribute to @entity0 resistance. The collective results indicate that vexR is required for vexRAB expression in response to VexAB substrates and that the VexAB RND efflux system modulates the intracellular levels of metabolites that could otherwise accumulate to toxic levels.

title: Substrate-Dependent Activation of the XXXX vexAB RND Efflux System Requires vexR.

answer: @entity1


abstract: CONTEXT: MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression post-transcriptionally. Whether differently expressed miRNAs contribute to promoting granulosa cell proliferation in @entity2 ( @entity2 ) remains unknown. OBJECTIVE: We explored whether certain miRNAs are involved in the @entity2 of @entity2 and the mechanism of increased granulosa cells proliferation. @entity0 and Cells: miRNA expression was analyzed in excised ovarian cortexes from 16 @entity0 with @entity2 and 8 non- @entity2 . An immortalized @entity0 granulosa (KGN) cell was used for the mechanism study. MAIN OUTCOME MEASURES: Expressions of miRNAs in ovarian cortexes were measured using qRT-PCR and KGN granulosa cells were cultured for proliferation assays after overexpression or inhibition of @entity4 or after @entity3 treatment. Bioinformatics were used to identify the potential miRNA targets. Protein expression analysis, luciferase assays, and rescue assays were used to confirm the substrate of @entity4 . RESULTS: @entity4 expression was higher in @entity2 ovarian cortex and its identified target, @entity1 , was downregulated. @entity4 overexpression promoted cell proliferation and G1 to S transition. Knocking down @entity1 promoted cell growth and cell cycle progression in granulosa cells, and @entity1 re-introduction reversed the promotional role of @entity4 . High concentrations of @entity3 induced upregulation of @entity4 , stimulated KGN cells proliferation and reduced @entity1 expression. CONCLUSIONS: @entity4 was increased in @entity2 granulosa cells and targeted @entity1 to promote proliferation and cell cycle progression. @entity3 could upregulate the expression of @entity4 and stimulate cell proliferation. This might provide a new insight into the dysfunction of granulosa cells in @entity2 .

title: @entity4 Promotes Ovarian Granulosa Cells Proliferation Through Targeting XXXX in Polycystic Ovarian Syndrome.

answer: @entity1


abstract: CONTEXT: MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression post-transcriptionally. Whether differently expressed miRNAs contribute to promoting granulosa cell proliferation in @entity2 ( @entity2 ) remains unknown. OBJECTIVE: We explored whether certain miRNAs are involved in the @entity2 of @entity2 and the mechanism of increased granulosa cells proliferation. @entity0 and Cells: miRNA expression was analyzed in excised ovarian cortexes from 16 @entity0 with @entity2 and 8 non- @entity2 . An immortalized @entity0 granulosa (KGN) cell was used for the mechanism study. MAIN OUTCOME MEASURES: Expressions of miRNAs in ovarian cortexes were measured using qRT-PCR and KGN granulosa cells were cultured for proliferation assays after overexpression or inhibition of @entity4 or after @entity3 treatment. Bioinformatics were used to identify the potential miRNA targets. Protein expression analysis, luciferase assays, and rescue assays were used to confirm the substrate of @entity4 . RESULTS: @entity4 expression was higher in @entity2 ovarian cortex and its identified target, @entity1 , was downregulated. @entity4 overexpression promoted cell proliferation and G1 to S transition. Knocking down @entity1 promoted cell growth and cell cycle progression in granulosa cells, and @entity1 re-introduction reversed the promotional role of @entity4 . High concentrations of @entity3 induced upregulation of @entity4 , stimulated KGN cells proliferation and reduced @entity1 expression. CONCLUSIONS: @entity4 was increased in @entity2 granulosa cells and targeted @entity1 to promote proliferation and cell cycle progression. @entity3 could upregulate the expression of @entity4 and stimulate cell proliferation. This might provide a new insight into the dysfunction of granulosa cells in @entity2 .

title: XXXX Promotes Ovarian Granulosa Cells Proliferation Through Targeting @entity1 in Polycystic Ovarian Syndrome.

answer: @entity4


abstract: OBJECTIVES: To evaluate the rate control in the @entity3 @entity0 and to identify the predictive factors of non-control. METHODS: It was about a cross-sectional study with prospective collection of data over a period of 36months. It has been held in Brazzaville, and included a consecutive series of 620 @entity3 @entity0 known and treated for at least 6weeks, having profited from an ambulatory blood pressure monitoring (ABPM) with therapeutic aiming. We used the TONOPORT V and the software Cardiosoft 6.51 of GE Health Care, respectively for the recording and the data analysis. The threshold fixed on the average of 24-hour was BP<130/80mmHg, and the @entity0 divided into two groups according to whether they were or not controlled. RESULTS: They were 352 @entity0 (56.8%) and 268 @entity0 (43.2%), old on average of 53.8  9.7years (ranges: 29 and 89years). The standard of living of the @entity0 was average in 330 cases (53.2%), weak in 132 cases (21.3%), and high in 71 cases (11.5%). The other associated risk factors were sedentariness in 275 cases (44.4%), overweight/ @entity2 in 134 cases (21.6%), @entity5 in 121 cases (19.5%), @entity1 in 90 cases (14.5%), and @entity4 addiction in 25 cases (4%). The @entity3 , old of 5.8  5.7 years on average, was controlled among 215 @entity0 (34.7%). The 24- hour BP average was 139  14mmHg for the @entity6 and 88.2  10.2mmHg for the @entity7 . The awake and asleep BP averages were respectively 141  14mmHg and 133  16.2mmHg for the @entity6 , 90.5  10.5 and 81.2  11.1mmHg for the @entity7 . The antihypertensive protocol used was a monotherapy in 130 cases (21%), bitherapy in 287 cases (46.3%), tritherapy in 154 cases (24.8%), quadritherapy or more in 27 cases (4.3%). Prevalence of non-dipping was 43%. Age and male gender were the significant predictors of poor control. CONCLUSION: The rate control of @entity3 in our study population remains low. Its improvement passes by the education of the @entity3 @entity0 and the improvement of their living conditions.

title: [ XXXX and rate control in Brazzaville (Congo): Place of ambulatory blood pressure monitoring (ABPM).]

answer: @entity3


abstract: BACKGROUND: @entity1 ( @entity1 ) may lead to myocardial preconditioning by increasing coronary collateral vessel recruitment in @entity0 with acute @entity5 . AIM: To determine the relationship between the severity of @entity1 and @entity2 during @entity3 . METHODS: This study prospectively included 71 @entity0 with an inaugural @entity3 who had undergone a coronary angiography within 24h of onset. All @entity0 underwent an overnight polygraph before discharge and were classified according to the @entity1 index (AHI). Coronary collaterals were scored by visual analyses and according to the Rentrop grading system. RESULTS: Mean age was 59  11years and 83% of @entity0 were @entity0 . All @entity0 had complete or subtotal occlusion of the @entity4 . After the sleep study, @entity0 were divided into two groups: 25 were suffering from @entity1 (AHI>15/h). @entity0 with @entity1 showed better collateral vessel development (Rentrop score>= 1) compared to non- @entity1 @entity0 (68 vs. 41%, P=0.032). AHI was significantly higher in @entity0 with developed coronary collaterals (Rentrop>= 1) compared to those without collaterality (17.74  13.2 vs. 12.24  10.9, P=0.025). CONCLUSION: Coronary collateral development may be increased in @entity1 @entity0 who are presenting with a first @entity3 .

title: XXXX in recruitment of @entity2 during inaugural @entity3 .

answer: @entity1


abstract: BACKGROUND: @entity1 ( @entity1 ) may lead to myocardial preconditioning by increasing coronary collateral vessel recruitment in @entity0 with acute @entity5 . AIM: To determine the relationship between the severity of @entity1 and @entity2 during @entity3 . METHODS: This study prospectively included 71 @entity0 with an inaugural @entity3 who had undergone a coronary angiography within 24h of onset. All @entity0 underwent an overnight polygraph before discharge and were classified according to the @entity1 index (AHI). Coronary collaterals were scored by visual analyses and according to the Rentrop grading system. RESULTS: Mean age was 59  11years and 83% of @entity0 were @entity0 . All @entity0 had complete or subtotal occlusion of the @entity4 . After the sleep study, @entity0 were divided into two groups: 25 were suffering from @entity1 (AHI>15/h). @entity0 with @entity1 showed better collateral vessel development (Rentrop score>= 1) compared to non- @entity1 @entity0 (68 vs. 41%, P=0.032). AHI was significantly higher in @entity0 with developed coronary collaterals (Rentrop>= 1) compared to those without collaterality (17.74  13.2 vs. 12.24  10.9, P=0.025). CONCLUSION: Coronary collateral development may be increased in @entity1 @entity0 who are presenting with a first @entity3 .

title: @entity1 in recruitment of XXXX during inaugural @entity3 .

answer: @entity2


abstract: BACKGROUND: @entity1 ( @entity1 ) may lead to myocardial preconditioning by increasing coronary collateral vessel recruitment in @entity0 with acute @entity5 . AIM: To determine the relationship between the severity of @entity1 and @entity2 during @entity3 . METHODS: This study prospectively included 71 @entity0 with an inaugural @entity3 who had undergone a coronary angiography within 24h of onset. All @entity0 underwent an overnight polygraph before discharge and were classified according to the @entity1 index (AHI). Coronary collaterals were scored by visual analyses and according to the Rentrop grading system. RESULTS: Mean age was 59  11years and 83% of @entity0 were @entity0 . All @entity0 had complete or subtotal occlusion of the @entity4 . After the sleep study, @entity0 were divided into two groups: 25 were suffering from @entity1 (AHI>15/h). @entity0 with @entity1 showed better collateral vessel development (Rentrop score>= 1) compared to non- @entity1 @entity0 (68 vs. 41%, P=0.032). AHI was significantly higher in @entity0 with developed coronary collaterals (Rentrop>= 1) compared to those without collaterality (17.74  13.2 vs. 12.24  10.9, P=0.025). CONCLUSION: Coronary collateral development may be increased in @entity1 @entity0 who are presenting with a first @entity3 .

title: @entity1 in recruitment of @entity2 during inaugural XXXX .

answer: @entity3


abstract: UNASSIGNED: Elucidation of cellular mechanisms regulating myometrial contractility is crucial for improvement in management of many @entity5 , such as @entity8 , uterine @entity6 and post-partum @entity4 . Myometrial contractions are triggered by periodic synchronous rises in intracellular @entity3 concentration ([ @entity1 ]i) elicited by spontaneously generated action potentials propagating throughout the entire myometrium. During labour, hormones like @entity2 and @entity7 potentiate uterine contractions by increasing their duration, strength and frequency. The most informative approach to studying the mechanisms underlying hormonal modulation of uterine contractility is to record [ @entity1 ]i responses to hormones in intact myometrial samples that have not been subjected to enzymatic treatment for cell isolation or cell culture conditions. However, the spatio-temporal resolution of such recording is limited due to the motion artifacts occurring in contracting tissue. Here we describe the application of our newly developed motion correction algorithm to investigate the [ @entity1 ]i dynamics in control and @entity2 stimulated slices of @entity0 myometrium on a cellular level. We present evidence that @entity2 induces asynchronous [ @entity1 ]i oscillations in individual myocytes within intact myometrium which are similar to those observed in cultured cells. The oscillations occur between synchronous action potential-driven [ @entity1 ]i transients but appear to be unrelated to contractions. Furthermore, the @entity2 -triggered [ @entity1 ]i oscillations wane within 30-50min of hormone application, while the action potential induced [ @entity1 ]i transients remain augmented. We conclude that @entity2 -induced [ @entity1 ]i oscillations are not relevant to the acute regulation of myometrial contractility but may play a role in longer-term regulatory processes, for example, by triggering gene expression.

title: Single-cell mechanics and XXXX signalling in organotypic slices of @entity0 myometrium.

answer: @entity3


abstract: UNASSIGNED: Elucidation of cellular mechanisms regulating myometrial contractility is crucial for improvement in management of many @entity5 , such as @entity8 , uterine @entity6 and post-partum @entity4 . Myometrial contractions are triggered by periodic synchronous rises in intracellular @entity3 concentration ([ @entity1 ]i) elicited by spontaneously generated action potentials propagating throughout the entire myometrium. During labour, hormones like @entity2 and @entity7 potentiate uterine contractions by increasing their duration, strength and frequency. The most informative approach to studying the mechanisms underlying hormonal modulation of uterine contractility is to record [ @entity1 ]i responses to hormones in intact myometrial samples that have not been subjected to enzymatic treatment for cell isolation or cell culture conditions. However, the spatio-temporal resolution of such recording is limited due to the motion artifacts occurring in contracting tissue. Here we describe the application of our newly developed motion correction algorithm to investigate the [ @entity1 ]i dynamics in control and @entity2 stimulated slices of @entity0 myometrium on a cellular level. We present evidence that @entity2 induces asynchronous [ @entity1 ]i oscillations in individual myocytes within intact myometrium which are similar to those observed in cultured cells. The oscillations occur between synchronous action potential-driven [ @entity1 ]i transients but appear to be unrelated to contractions. Furthermore, the @entity2 -triggered [ @entity1 ]i oscillations wane within 30-50min of hormone application, while the action potential induced [ @entity1 ]i transients remain augmented. We conclude that @entity2 -induced [ @entity1 ]i oscillations are not relevant to the acute regulation of myometrial contractility but may play a role in longer-term regulatory processes, for example, by triggering gene expression.

title: Single-cell mechanics and @entity3 signalling in organotypic slices of XXXX myometrium.

answer: @entity0


abstract: UNASSIGNED: @entity4 are caused by mutations in @entity5 . Cardiac manifestations vary broadly, making prognosis difficult. Current @entity5 genotype-cardiac phenotype correlations are limited. For skeletal muscle, the reading-frame rule suggests in-frame mutations tend to yield milder phenotypes. We performed @entity5 genotype-cardiac phenotype correlations using a protein-effect model and cardiac magnetic resonance imaging. A translational model was applied to @entity0 -specific deletion, indel, and nonsense mutations to predict exons and protein domains present within truncated @entity5 protein. @entity0 were dichotomized into predicted present and predicted absent groups for exons and protein domains of interest. Development of @entity1 (represented by late gadolinium enhancement [LGE]) and depressed @entity3 ( @entity3 ) were compared. @entity0 (n  = 274) with predicted present @entity6 ( @entity6 ), C-terminal domain (CTD), and both the N-terminal actin-binding and cysteine-rich domains (ABD1  + @entity6 ) had a decreased risk of LGE and trended toward greater freedom from LGE. @entity0 with predicted present CTD (exactly the same as those with in-frame mutations) and ABD1  + @entity6 trended toward decreased risk of and greater freedom from depressed @entity3 . In conclusion, genotypes previously implicated in altering the @entity2 phenotype were not significantly related to LGE and depressed @entity3 . @entity0 with predicted present @entity6 , CTD/in-frame mutations, and ABD1  + @entity6 trended toward milder cardiac phenotypes, suggesting that the reading-frame rule may be applicable to the cardiac phenotype. Genotype-phenotype correlations may help predict the  cardiac phenotype for dystrophinopathic @entity0 and guide future therapies.

title: XXXX Genotype-Cardiac Phenotype Correlations in @entity4 Using Cardiac Magnetic Resonance Imaging.

answer: @entity5


abstract: UNASSIGNED: @entity4 are caused by mutations in @entity5 . Cardiac manifestations vary broadly, making prognosis difficult. Current @entity5 genotype-cardiac phenotype correlations are limited. For skeletal muscle, the reading-frame rule suggests in-frame mutations tend to yield milder phenotypes. We performed @entity5 genotype-cardiac phenotype correlations using a protein-effect model and cardiac magnetic resonance imaging. A translational model was applied to @entity0 -specific deletion, indel, and nonsense mutations to predict exons and protein domains present within truncated @entity5 protein. @entity0 were dichotomized into predicted present and predicted absent groups for exons and protein domains of interest. Development of @entity1 (represented by late gadolinium enhancement [LGE]) and depressed @entity3 ( @entity3 ) were compared. @entity0 (n  = 274) with predicted present @entity6 ( @entity6 ), C-terminal domain (CTD), and both the N-terminal actin-binding and cysteine-rich domains (ABD1  + @entity6 ) had a decreased risk of LGE and trended toward greater freedom from LGE. @entity0 with predicted present CTD (exactly the same as those with in-frame mutations) and ABD1  + @entity6 trended toward decreased risk of and greater freedom from depressed @entity3 . In conclusion, genotypes previously implicated in altering the @entity2 phenotype were not significantly related to LGE and depressed @entity3 . @entity0 with predicted present @entity6 , CTD/in-frame mutations, and ABD1  + @entity6 trended toward milder cardiac phenotypes, suggesting that the reading-frame rule may be applicable to the cardiac phenotype. Genotype-phenotype correlations may help predict the  cardiac phenotype for dystrophinopathic @entity0 and guide future therapies.

title: @entity5 Genotype-Cardiac Phenotype Correlations in XXXX Using Cardiac Magnetic Resonance Imaging.

answer: @entity4


abstract: OBJECTIVE: The aim of our current research project is to further evaluate the role of risk factors in the pathogenesis of @entity5 ; these include genetic variations, environmental factors and lifestyle issues. METHODS: We have been conducting an association study on 373 @entity0 with @entity5 and 286 unrelated control individuals. The occurrence and the age of onset of @entity1 and @entity3 were evaluated in both groups. @entity6 genotype was analyzed in all subjects by PCR method. RESULTS: We report that, in Czech population carrying @entity6 allele increases risk of @entity5 2.1-fold and genotype E4E4 increases the risk 8.4-fold. We have also identified a significant association between @entity6 allele, @entity5 and @entity4 . @entity4 subjects with the @entity6 allele have 1.5-fold greater risk of @entity5 . Thus, @entity4 together with @entity6 allele translates into 1.5-fold higher risk of @entity5 . The most intriguing original finding in the present study is that @entity5 @entity0 have significantly later onset of @entity1 , @entity4 and @entity2 in comparison with control subjects. This effect was not influenced by @entity6 genotype. The @entity1 appeared in @entity5 @entity0 on average more than 10 years later than in the control subjects (p<0.0001), @entity4 was diagnosed 14 years later in @entity5 @entity0 (p<0.00001) and @entity2 occurred on average 6 years later (p<0.005), compared to the control group. CONCLUSIONS: Overall, in addition to the above novel findings, our study expands the data base on risk factors that could be used in near future when testing for the genetic risk of @entity5 .

title: @entity1 , @entity4 and XXXX - does Alzheimer protect you?

answer: @entity2


abstract: OBJECTIVE: The aim of our current research project is to further evaluate the role of risk factors in the pathogenesis of @entity5 ; these include genetic variations, environmental factors and lifestyle issues. METHODS: We have been conducting an association study on 373 @entity0 with @entity5 and 286 unrelated control individuals. The occurrence and the age of onset of @entity1 and @entity3 were evaluated in both groups. @entity6 genotype was analyzed in all subjects by PCR method. RESULTS: We report that, in Czech population carrying @entity6 allele increases risk of @entity5 2.1-fold and genotype E4E4 increases the risk 8.4-fold. We have also identified a significant association between @entity6 allele, @entity5 and @entity4 . @entity4 subjects with the @entity6 allele have 1.5-fold greater risk of @entity5 . Thus, @entity4 together with @entity6 allele translates into 1.5-fold higher risk of @entity5 . The most intriguing original finding in the present study is that @entity5 @entity0 have significantly later onset of @entity1 , @entity4 and @entity2 in comparison with control subjects. This effect was not influenced by @entity6 genotype. The @entity1 appeared in @entity5 @entity0 on average more than 10 years later than in the control subjects (p<0.0001), @entity4 was diagnosed 14 years later in @entity5 @entity0 (p<0.00001) and @entity2 occurred on average 6 years later (p<0.005), compared to the control group. CONCLUSIONS: Overall, in addition to the above novel findings, our study expands the data base on risk factors that could be used in near future when testing for the genetic risk of @entity5 .

title: @entity1 , XXXX and @entity2 - does Alzheimer protect you?

answer: @entity4


abstract: OBJECTIVE: The aim of our current research project is to further evaluate the role of risk factors in the pathogenesis of @entity5 ; these include genetic variations, environmental factors and lifestyle issues. METHODS: We have been conducting an association study on 373 @entity0 with @entity5 and 286 unrelated control individuals. The occurrence and the age of onset of @entity1 and @entity3 were evaluated in both groups. @entity6 genotype was analyzed in all subjects by PCR method. RESULTS: We report that, in Czech population carrying @entity6 allele increases risk of @entity5 2.1-fold and genotype E4E4 increases the risk 8.4-fold. We have also identified a significant association between @entity6 allele, @entity5 and @entity4 . @entity4 subjects with the @entity6 allele have 1.5-fold greater risk of @entity5 . Thus, @entity4 together with @entity6 allele translates into 1.5-fold higher risk of @entity5 . The most intriguing original finding in the present study is that @entity5 @entity0 have significantly later onset of @entity1 , @entity4 and @entity2 in comparison with control subjects. This effect was not influenced by @entity6 genotype. The @entity1 appeared in @entity5 @entity0 on average more than 10 years later than in the control subjects (p<0.0001), @entity4 was diagnosed 14 years later in @entity5 @entity0 (p<0.00001) and @entity2 occurred on average 6 years later (p<0.005), compared to the control group. CONCLUSIONS: Overall, in addition to the above novel findings, our study expands the data base on risk factors that could be used in near future when testing for the genetic risk of @entity5 .

title: XXXX , @entity4 and @entity2 - does Alzheimer protect you?

answer: @entity1


abstract: AIMS AND BACKGROUND: In this retrospective analysis, we evaluated the use of stereotactic body radiation therapy in the management of adrenal metastases from @entity4 and report our single center experience. METHODS AND STUDY DESIGN: Fifteen @entity4 @entity0 (9 male, 6 female) with 17 adrenal metastases referred to Gulhane Military Medical Academy Radiation Oncology Department were treated using active breathing control-guided stereotactic body radiation therapy between December 2009 and October 2013. Dose per fraction was 10 Gy to deliver a total dose of 30 Gy over 3 consecutive days for all metastatic adrenal lesions. The mean gross @entity1 volume was 28.4 cc (range 6.6-101.5) and mean planning target volume was 57.4 cc (range 16.5-143.8). RESULTS: At a median follow-up of 16 months, local control was 86.7% and overall survival was 33.3%. Median disease-free survival was 10 months. Treatment response according to RECIST was categorized as complete response in 3 @entity0 (20%), partial response in 5 @entity0 (33.3%), stable disease in 5 @entity0 (33.3%), and progressive disease in 2 @entity0 (13.3%). Most common acute @entity2 was grade 1 @entity3 (n = 7) and grade 1 @entity5 (n = 12). There was no case of grade >= 3 acute or late @entity2 . CONCLUSIONS: Stereotactic body radiation therapy offers a safe and efficacious management strategy for adrenal metastases from @entity4 by providing excellent local control with negligible treatment related @entity2 .

title: Evaluation of stereotactic body radiation therapy in the management of adrenal metastases from XXXX .

answer: @entity4


abstract: BACKGROUND: The @entity1 -sensitive @entity3 channel (IK( @entity4 )) expresses only in the atrium, not in the ventricle. The main component of the @entity0 IK( @entity4 ) channel is the Kir3.4 protein, and its encoding gene is the @entity6 gene. IK( @entity4 ) inhibitors provide a promising treatment for @entity2 without side effects on the ventricle. At present, however, there is no specific IK( @entity4 ) inhibitor. Small interference RNA (siRNA) has the advantages of high specificity and high efficiency. Our aim is to use siRNA to inhibit the IK( @entity4 ) channel on H9c2 cells derived from @entity0 cardiomyocytes. METHODS: Three pairs of siRNAs targeting the @entity0 IK( @entity4 ) channel were synthesized. H9c2 cells were divided into six groups: control, negative siRNA control, siRNA sequence 1, siRNA sequence 2, siRNA sequence 3, and @entity5 . The @entity6 gene and Kir3.4 protein were measured, and IK( @entity4 ) currents were recorded by patch-clamp. RESULTS: The negative siRNA control and siRNA sequence 1 had no inhibitory effects on the IK( @entity4 ) channel. siRNA sequences 2 and 3 could cause a significant decrease in @entity6 gene expression, Kir3.4 protein, and IK( @entity4 ) currents (p<0.05). @entity5 could inhibit the IK( @entity4 ) currents but had no effect on @entity6 gene expression and Kir3.4 protein. CONCLUSION: siRNA could effectively inhibit the IK( @entity4 ) channel and is a potential therapy for @entity2 .

title: Effect of Small Interference RNA on the XXXX -Sensitive @entity3 Channel in H9c2 Cells.

answer: @entity1


abstract: BACKGROUND: The @entity1 -sensitive @entity3 channel (IK( @entity4 )) expresses only in the atrium, not in the ventricle. The main component of the @entity0 IK( @entity4 ) channel is the Kir3.4 protein, and its encoding gene is the @entity6 gene. IK( @entity4 ) inhibitors provide a promising treatment for @entity2 without side effects on the ventricle. At present, however, there is no specific IK( @entity4 ) inhibitor. Small interference RNA (siRNA) has the advantages of high specificity and high efficiency. Our aim is to use siRNA to inhibit the IK( @entity4 ) channel on H9c2 cells derived from @entity0 cardiomyocytes. METHODS: Three pairs of siRNAs targeting the @entity0 IK( @entity4 ) channel were synthesized. H9c2 cells were divided into six groups: control, negative siRNA control, siRNA sequence 1, siRNA sequence 2, siRNA sequence 3, and @entity5 . The @entity6 gene and Kir3.4 protein were measured, and IK( @entity4 ) currents were recorded by patch-clamp. RESULTS: The negative siRNA control and siRNA sequence 1 had no inhibitory effects on the IK( @entity4 ) channel. siRNA sequences 2 and 3 could cause a significant decrease in @entity6 gene expression, Kir3.4 protein, and IK( @entity4 ) currents (p<0.05). @entity5 could inhibit the IK( @entity4 ) currents but had no effect on @entity6 gene expression and Kir3.4 protein. CONCLUSION: siRNA could effectively inhibit the IK( @entity4 ) channel and is a potential therapy for @entity2 .

title: Effect of Small Interference RNA on the @entity1 -Sensitive XXXX Channel in H9c2 Cells.

answer: @entity3


abstract: BACKGROUND: @entity0 are relatively protected against @entity3 ( @entity3 ). Whether female gender has a similar protective influence on the development of @entity4 ( @entity4 ) has not been extensively investigated and was the main subject of our study. METHODS: We analysed 2707 consecutive @entity0 (2008 @entity0 and 699 @entity0 ) who underwent a first diagnostic coronary angiography for suspicion of @entity3 and 2367 consecutive @entity0 (1426 @entity0 and 941 @entity0 ) who underwent a first ankle arm index measurement because of suspicion of @entity4 . RESULTS: We found that a positive diagnosis for @entity3 and @entity4 was more common in @entity0 compared with @entity0 (80.7% vs 57.9%, p<0.0001 and 68.0% vs 60.7%, p<0.0001). Once @entity3 or @entity4 was established, severity of disease was similar for @entity0 and @entity0 , which pleads against a referral bias. @entity0 had a reduced risk of @entity3 after adjustment for risk factors (odds ratio [OR] 0.32, 95% confidence interval [CI] 0.22-0.46, p<0.0001), but not of @entity4 (OR 0.82, 95% CI 0.66-1.03, p=NS). In @entity0 with @entity3 and in those with @entity4 , @entity0 were older, more often had @entity1 and @entity2 , while @entity0 were more likely to be current smokers. @entity2 , smoking and @entity1 were associated with @entity3 in both @entity0 and @entity0 . Current smoking was associated with @entity4 in @entity0 and @entity0 . @entity2 and @entity1 were associated with @entity4 in @entity0 but not in @entity0 . CONCLUSION: After adjustment for risk factors, the female protection for @entity3 seems to less present for @entity4 .

title: Differential effect of female gender on @entity3 and XXXX .

answer: @entity4


abstract: BACKGROUND: @entity0 are relatively protected against @entity3 ( @entity3 ). Whether female gender has a similar protective influence on the development of @entity4 ( @entity4 ) has not been extensively investigated and was the main subject of our study. METHODS: We analysed 2707 consecutive @entity0 (2008 @entity0 and 699 @entity0 ) who underwent a first diagnostic coronary angiography for suspicion of @entity3 and 2367 consecutive @entity0 (1426 @entity0 and 941 @entity0 ) who underwent a first ankle arm index measurement because of suspicion of @entity4 . RESULTS: We found that a positive diagnosis for @entity3 and @entity4 was more common in @entity0 compared with @entity0 (80.7% vs 57.9%, p<0.0001 and 68.0% vs 60.7%, p<0.0001). Once @entity3 or @entity4 was established, severity of disease was similar for @entity0 and @entity0 , which pleads against a referral bias. @entity0 had a reduced risk of @entity3 after adjustment for risk factors (odds ratio [OR] 0.32, 95% confidence interval [CI] 0.22-0.46, p<0.0001), but not of @entity4 (OR 0.82, 95% CI 0.66-1.03, p=NS). In @entity0 with @entity3 and in those with @entity4 , @entity0 were older, more often had @entity1 and @entity2 , while @entity0 were more likely to be current smokers. @entity2 , smoking and @entity1 were associated with @entity3 in both @entity0 and @entity0 . Current smoking was associated with @entity4 in @entity0 and @entity0 . @entity2 and @entity1 were associated with @entity4 in @entity0 but not in @entity0 . CONCLUSION: After adjustment for risk factors, the female protection for @entity3 seems to less present for @entity4 .

title: Differential effect of female gender on XXXX and @entity4 .

answer: @entity3


abstract: UNASSIGNED: A randomized trial was conducted prospectively to evaluate the efficacy, related complications, and convalescence of emergent retrograde ureteroscopic management, instead of percutaneous nephrostomy for decompression of the collecting system in cases of @entity1 associated with @entity2 . A total of 107 @entity0 undergoing ureteroscopic stone manipulation for ureteral stones completed the study protocol, 53 @entity0 in the percutaneous nephrostomy group, and 54 @entity0 in the emergent retrograde ureteroscopic management group. The primary end point was the time to normalization of WBC of 10,000/mm or less and temperature of 37.4    C or less. The second end point was the comparison analgesic consumption, length of stay, and related complications. Statistical analysis was performed using SPSS(  ) version 14.0.1. The Mann-Whitney U test, Chi square test, and fisher's exact test was used as appropriate. The length of hospital stay (days) was 10.25      3.53 and 8.24      2.77 in the percutaneous nephrostomy group and emergent retrograde ureteroscopic management group, respectively, with significant difference (Table  2). However, @entity0 in the emergent retrograde ureteroscopic management group had a significantly higher rate of s body temperature (  C). Meanwhile, the analgesic consumptions are 31.51      11.16 and 40.00      14.54 in the percutaneous nephrostomy group and emergent retrograde ureteroscopic management group, respectively, with significant difference. Our results show that it can be effectively and safely managed by retrograde ureteroscopic management combined with strong antibiotics in select clinical situations. Ureteroscopic management should no longer be considered a contraindication for the treatment of @entity0 with @entity1 associated with obstructing ureteral stones.

title: Percutaneous nephrostomy versus ureteroscopic management of XXXX associated with ureteral stone impaction: a randomized controlled trial.

answer: @entity1


abstract: BACKGROUND/AIMS: Hepatopancreatoduodenectomy (HPD) is performed to achieve radical resection of @entity2 . We reviewed clinical outcomes to evaluate the utility of HPD in terms of morbidity and mortality. METHODOLOGY: A retrospective analysis was conducted on 17 @entity0 underwent HPD between August 1991 and May 2013; 9 @entity6 , 5 advanced gallbladder and 3 @entity4 with liver @entity1 . RESULTS: The morbidity and mortality rates were 88.3% and 0%, respectively. Univariate analysis showed that a body mass index of >= 22 and preoperative total @entity3 level >= 0.8 mg/dl were significantly associated with severe complications. One-, 3- and 5-year survival rate were 73.3%, 60.0% and 30.0%. In 14 @entity0 with @entity5 , univariate analysis showed that a histological grade of G1 was significantly associated with survival. @entity0 without pancreatic invasion or portal vein invasion tended to survive longer than @entity0 with these types of invasion, although the difference was not significant. CONCLUSIONS: HPD can be performed with no mortality and provides a survival benefit for some @entity0 with @entity5 undergoing curative resection. In @entity0 with grade G1 @entity5 without @entity4 in particular, this aggressive surgery might offer a chance of long-term survival.

title: Risk factors of morbidity and predictors of long-term survival after hepatopancreatoduodenectomy for XXXX .

answer: @entity2


abstract: BACKGROUND/AIMS: @entity2 ( @entity2 ) is one of the most common @entity1 , and liver @entity0 is one of the major causes of death of @entity2 . This study aimed to compare the genetic difference between metachronous lesions (MC) and @entity3 ( @entity3 ) and explore the molecular pathology of @entity2 @entity0 . METHODOLOGY: Microarray expression profile data (GSE10961) including 8 MC and 10 @entity3 was downloaded from Gene Expression Omnibus. The differentially expressed genes (DEGs) between the two groups were identified based on T test. Furthermore, GO enrichment analysis was performed for the down-regulated DEGs using DAVID. Finally, Classify validation of known @entity2 genes based on previous studies between MC and @entity3 samples was conducted. RESULTS: Total of 36 DEGs including 35 down-regulated DEGs and 1 up-regulated DEGs were identified. The expressional differences of the 5 informative oncogenes: EGFr, @entity11 , @entity6 ( @entity5 ), @entity8 ( @entity10 ), and @entity4 between @entity3 and MC were really tiny. CONCLUSIONS: Some DEGs, such as @entity12 , @entity7 , @entity13 , @entity14 and @entity9 might play crucial roles in the regulation of @entity2 @entity0 (both @entity3 and MC) and by disrupting some pathways. However, our results indeed demand further research and experiment.

title: Comparison analysis in synchronous and metachronous metastatic XXXX based on microarray expression profile.

answer: @entity2


abstract: Five normal adults and 31 @entity0 with @entity2 were studied by stress test, and 201Tl was injected one min. before the end of the test. Myocardial scintigrams in three views were recorded @entity3 ) after the injection. The myocardial wall was geometrically divided into 5 segments. At the area where the count rate (Cts) was highest in phase 0 scintigrams, the washout rate from phase i to j was defined as WRij = (maxCtsi-maxCtsj)/maxCtsi where Ctsi denoted Cts at phase i in the relevant area. The redistribution index (Rdsij) in each segment was defined as Rdsij = [Ctsi X WRij + (Ctsi - Ctsj)]/Ctsi, where Ctsi denoted Cts at phase i in the segment. The @entity1 segment was identified as 70% or less of maxCts 0, while the infarcted segment by VCG in phase 0 scintigram. Mean values of Rds 02 in the normal, @entity1 and infarcted segments were -6.1 +/- 5.6, 9.7 +/- 7.0 and 3.5 +/- 7.2%, respectively, and the differences were statistically significant (p less than 0.001). All the 26 @entity0 with anginal except one showed WR 12/WR 01 greater than 1.0. When the peak pressure rate product that attained at the test was 200 or more, it was significantly correlated with WR 02 (r = 0.80). The Redistribution index was helpful in quantitative assessment of the @entity1 segments. The finding of WR 12 greater than WR 01 after the stress was reliable in suggesting @entity2 .

title: [Quantitative evaluation of serial 201Tl Myocardial scintigrams after stress testing in XXXX (author's transl)].

answer: @entity2