abstract: UNASSIGNED: Cigarette smoking is the major aetiologic factor in @entity6 ( @entity6 ). Lung fibroblasts are key @entity0 in the maintenance of the extracellular matrix within the lung parenchyma. However, it still remains unknown how pulmonary fibroblasts are affected by cigarette smoking. Therefore, in this study, we isolated lung fibroblasts from @entity1 and determined the apoptotic mechanism in response to @entity9 ( @entity9 ). When the lung fibroblasts were exposed to @entity9 , the generation of ROS was increased as shown by @entity13 staining and Flow Cytometry. By immunocytochemistry, @entity17 expressing cells gradually decreased in a dose-dependent manner. The @entity11 concentration in the supernatants increased, while the SOD activity and @entity12 recycling decreased in response to @entity9 . @entity9 increased the mRNA levels of @entity4 and @entity15 , and the secretory proteins @entity4 and @entity5 increased as measured by ELISA. We next determined whether this inflammatory process is associated with the @entity8 / @entity7 apoptosis pathway. The @entity8 / @entity7 mRNA ratio increased, and cleaved @entity3 protein was activated in the lung fibroblasts treated with @entity9 . Moreover, @entity9 induced the phosphorylation of @entity18 at Tyr701/Ser727 and increased the activation of @entity14 , @entity10 , and @entity16 in the MAPK pathway. Taken together, these data suggest that @entity9 -mediated @entity2 alters the redox regulation via the MAPK- @entity18 pathway, leading to intrinsic apoptosis of lung fibroblasts.

title: Cigarette smoke-mediated oxidative stress induces apoptosis via the MAPKs/ XXXX pathway in @entity1 lung fibroblasts.

answer: @entity18


abstract: UNASSIGNED: Cigarette smoking is the major aetiologic factor in @entity6 ( @entity6 ). Lung fibroblasts are key @entity0 in the maintenance of the extracellular matrix within the lung parenchyma. However, it still remains unknown how pulmonary fibroblasts are affected by cigarette smoking. Therefore, in this study, we isolated lung fibroblasts from @entity1 and determined the apoptotic mechanism in response to @entity9 ( @entity9 ). When the lung fibroblasts were exposed to @entity9 , the generation of ROS was increased as shown by @entity13 staining and Flow Cytometry. By immunocytochemistry, @entity17 expressing cells gradually decreased in a dose-dependent manner. The @entity11 concentration in the supernatants increased, while the SOD activity and @entity12 recycling decreased in response to @entity9 . @entity9 increased the mRNA levels of @entity4 and @entity15 , and the secretory proteins @entity4 and @entity5 increased as measured by ELISA. We next determined whether this inflammatory process is associated with the @entity8 / @entity7 apoptosis pathway. The @entity8 / @entity7 mRNA ratio increased, and cleaved @entity3 protein was activated in the lung fibroblasts treated with @entity9 . Moreover, @entity9 induced the phosphorylation of @entity18 at Tyr701/Ser727 and increased the activation of @entity14 , @entity10 , and @entity16 in the MAPK pathway. Taken together, these data suggest that @entity9 -mediated @entity2 alters the redox regulation via the MAPK- @entity18 pathway, leading to intrinsic apoptosis of lung fibroblasts.

title: Cigarette smoke-mediated oxidative stress induces apoptosis via the MAPKs/ @entity18 pathway in XXXX lung fibroblasts.

answer: @entity1


abstract: Enteric administration of antigen can induce systemic tolerance. In @entity0 @entity7 mansoni, @entity6 produce eggs which enter the intestine. An immunologic phenomenon associated with this disease is a spontaneous diminution in the intensity of the granulomatous response in the liver, lungs, and @entity4 with @entity2 , which is termed modulation. It was determined whether modulation of liver @entity5 could be induced by enteric immunization with schistosome eggs. @entity0 infected for 4 wk were immunized by injection of 25,000 eggs into cecal pouches. This induced modulation of liver @entity5 by the eighth week of @entity2 . Neither cecal injection of normal saline nor i.p. or subcutaneous injection of eggs could induce the modulatory process. Modulation could be adoptively transferred from enterically immunized donors by injection of spleen cells into infected recipients or into uninfected recipients with synchronous liver @entity5 induced by the @entity1 of schistosome eggs. Spleen cells treated with anti- @entity8 or anti-Lyt-1.1 and complement could no longer adoptively transfer modulation. These data show that enteric immunization with schistosome eggs can induce modulation of the @entity3 by a cellular mechanism similar to that described for the natural @entity2 .

title: Induction of XXXX modulation in @entity0 @entity7 mansoni by enteric exposure to schistosome eggs.

answer: @entity5


abstract: Enteric administration of antigen can induce systemic tolerance. In @entity0 @entity7 mansoni, @entity6 produce eggs which enter the intestine. An immunologic phenomenon associated with this disease is a spontaneous diminution in the intensity of the granulomatous response in the liver, lungs, and @entity4 with @entity2 , which is termed modulation. It was determined whether modulation of liver @entity5 could be induced by enteric immunization with schistosome eggs. @entity0 infected for 4 wk were immunized by injection of 25,000 eggs into cecal pouches. This induced modulation of liver @entity5 by the eighth week of @entity2 . Neither cecal injection of normal saline nor i.p. or subcutaneous injection of eggs could induce the modulatory process. Modulation could be adoptively transferred from enterically immunized donors by injection of spleen cells into infected recipients or into uninfected recipients with synchronous liver @entity5 induced by the @entity1 of schistosome eggs. Spleen cells treated with anti- @entity8 or anti-Lyt-1.1 and complement could no longer adoptively transfer modulation. These data show that enteric immunization with schistosome eggs can induce modulation of the @entity3 by a cellular mechanism similar to that described for the natural @entity2 .

title: Induction of @entity5 modulation in @entity0 XXXX mansoni by enteric exposure to schistosome eggs.

answer: @entity7


abstract: Enteric administration of antigen can induce systemic tolerance. In @entity0 @entity7 mansoni, @entity6 produce eggs which enter the intestine. An immunologic phenomenon associated with this disease is a spontaneous diminution in the intensity of the granulomatous response in the liver, lungs, and @entity4 with @entity2 , which is termed modulation. It was determined whether modulation of liver @entity5 could be induced by enteric immunization with schistosome eggs. @entity0 infected for 4 wk were immunized by injection of 25,000 eggs into cecal pouches. This induced modulation of liver @entity5 by the eighth week of @entity2 . Neither cecal injection of normal saline nor i.p. or subcutaneous injection of eggs could induce the modulatory process. Modulation could be adoptively transferred from enterically immunized donors by injection of spleen cells into infected recipients or into uninfected recipients with synchronous liver @entity5 induced by the @entity1 of schistosome eggs. Spleen cells treated with anti- @entity8 or anti-Lyt-1.1 and complement could no longer adoptively transfer modulation. These data show that enteric immunization with schistosome eggs can induce modulation of the @entity3 by a cellular mechanism similar to that described for the natural @entity2 .

title: Induction of @entity5 modulation in XXXX @entity7 mansoni by enteric exposure to schistosome eggs.

answer: @entity0


abstract: AIM: Filtering techniques to remove manual compression artefacts from the ECG have not been incorporated to defibrillators to diagnose the rhythm during cardiopulmonary resuscitation. Mechanical and manual compression artefacts may be very different. The aim of this study is to characterize the compression artefact caused by the LUCAS 2 device and to evaluate whether filtering the LUCAS 2 artefact results in an accurate rhythm analysis. METHODS: A dataset of 1045 segments were obtained from 230 out-of-hospital @entity1 (OHCA) @entity0 after LUCAS 2 activation. Rhythms were 201 shockable, 270 @entity1 and 574 organized. Segments during @entity1 were used to characterize the artefact in time and frequency domains. Three filtering methods, a comb filter and two adaptive filters, were used to remove the mechanical compression artefact. The filtered ECG was then diagnosed with a shock decision algorithm from a defibrillator. RESULTS: When compared to the manual compression artefact, the LUCAS 2 artefact presented a similar amplitude (1.2mV, p-value 0.26), fixed frequency (101.7min(-1)), more harmonic components, smaller spectral dispersion, and a more regular waveform (p-val <3*10(-7)). The @entity2 ( @entity2 ) and specificity (SP) before filtering the LUCAS 2 artefact were 52.8% (90% low CI, 46.0%) and 81.5% (79.0%), respectively. For the best filter, @entity2 and SP after filtering were 97.9% (95.7%) and 84.1% (82.0%), respectively. Optimal filters require more harmonics and smaller bandwidths than for manual compressions. CONCLUSION: Filtering resulted in a large increase in @entity2 and small increase in SP. Despite differences in artefact characteristics between manual and mechanical compressions, filtering the LUCAS 2 compression artefact results in @entity2 /SP values comparable to those obtained for manual compression artefacts. The SP is still below the 95% recommended by the American Heart Association.

title: Filtering mechanical chest compression artefacts from out-of-hospital XXXX data.

answer: @entity1


abstract: Behavioural abnormalities such as @entity1 may develop when @entity0 with @entity2 receive dopaminergic therapy, although they can be controlled by deep brain stimulation of the subthalamic nucleus. We have recorded local field potentials in the subthalamic nucleus of 28 @entity0 with surgically implanted subthalamic electrodes. According to the predominant clinical features of each @entity0 , their @entity2 was associated with @entity1 (n = 10), @entity3 (n = 9) or no dopaminergic mediated motor or behavioural complications (n = 9). Recordings were obtained during the OFF and ON dopaminergic states and the power spectrum of the subthalamic activity as well as the subthalamocortical coherence were analysed using Fourier transform-based techniques. The position of each electrode contact was determined in the postoperative magnetic resonance image to define the topography of the oscillatory activity recorded in each @entity0 . In the OFF state, the three groups of @entity0 had similar oscillatory activity. By contrast, in the ON state, the @entity0 with @entity1 displayed theta-alpha (4-10 Hz) activity (mean peak: 6.71 Hz) that was generated 2-8 mm below the intercommissural line. Similarly, the @entity0 with @entity3 showed theta-alpha activity that peaked at a higher frequency (mean: 8.38 Hz) and was generated 0-2 mm below the intercommissural line. No such activity was detected in @entity0 that displayed no dopaminergic side effects. Cortico-subthalamic coherence was more frequent in the impulsive @entity0 in the 4-7.5 Hz range in scalp electrodes placed on the frontal regions anterior to the primary motor cortex, while in @entity0 with @entity3 it was in the 7.5-10 Hz range in the leads overlying the primary motor and supplementary motor area. Thus, dopaminergic side effects in @entity2 are associated with oscillatory activity in the theta-alpha band, but at different frequencies and with different topography for the motor ( @entity3 ) and behavioural (abnormal impulsivity) manifestations. These findings suggest that the activity recorded in @entity2 @entity0 with @entity1 stems from the associative-limbic area (ventral subthalamic area), which is coherent with premotor frontal cortical activity. Conversely, in @entity0 with l-dopa-induced @entity3 such activity is recorded in the motor area (dorsal subthalamic area) and it is coherent with cortical motor activity. Consequently, the subthalamic nucleus appears to be implicated in the motor and behavioural complications associated with dopaminergic drugs in @entity2 , specifically engaging different anatomo-functional territories.

title: Involvement of the subthalamic nucleus in @entity1 associated with XXXX .

answer: @entity2


abstract: Behavioural abnormalities such as @entity1 may develop when @entity0 with @entity2 receive dopaminergic therapy, although they can be controlled by deep brain stimulation of the subthalamic nucleus. We have recorded local field potentials in the subthalamic nucleus of 28 @entity0 with surgically implanted subthalamic electrodes. According to the predominant clinical features of each @entity0 , their @entity2 was associated with @entity1 (n = 10), @entity3 (n = 9) or no dopaminergic mediated motor or behavioural complications (n = 9). Recordings were obtained during the OFF and ON dopaminergic states and the power spectrum of the subthalamic activity as well as the subthalamocortical coherence were analysed using Fourier transform-based techniques. The position of each electrode contact was determined in the postoperative magnetic resonance image to define the topography of the oscillatory activity recorded in each @entity0 . In the OFF state, the three groups of @entity0 had similar oscillatory activity. By contrast, in the ON state, the @entity0 with @entity1 displayed theta-alpha (4-10 Hz) activity (mean peak: 6.71 Hz) that was generated 2-8 mm below the intercommissural line. Similarly, the @entity0 with @entity3 showed theta-alpha activity that peaked at a higher frequency (mean: 8.38 Hz) and was generated 0-2 mm below the intercommissural line. No such activity was detected in @entity0 that displayed no dopaminergic side effects. Cortico-subthalamic coherence was more frequent in the impulsive @entity0 in the 4-7.5 Hz range in scalp electrodes placed on the frontal regions anterior to the primary motor cortex, while in @entity0 with @entity3 it was in the 7.5-10 Hz range in the leads overlying the primary motor and supplementary motor area. Thus, dopaminergic side effects in @entity2 are associated with oscillatory activity in the theta-alpha band, but at different frequencies and with different topography for the motor ( @entity3 ) and behavioural (abnormal impulsivity) manifestations. These findings suggest that the activity recorded in @entity2 @entity0 with @entity1 stems from the associative-limbic area (ventral subthalamic area), which is coherent with premotor frontal cortical activity. Conversely, in @entity0 with l-dopa-induced @entity3 such activity is recorded in the motor area (dorsal subthalamic area) and it is coherent with cortical motor activity. Consequently, the subthalamic nucleus appears to be implicated in the motor and behavioural complications associated with dopaminergic drugs in @entity2 , specifically engaging different anatomo-functional territories.

title: Involvement of the subthalamic nucleus in XXXX associated with @entity2 .

answer: @entity1


abstract: Eighteen @entity0 with exclusively @entity3 of @entity4 were thymectomised. @entity1 , resistance to @entity5 therapy or relapse following immunosuppressive therapy were taken as indications for surgery. The mean preoperative observation period before operation was 40 months, and after operation was 26 months. There was no operative or postoperative morbidity or mortality. @entity6 were found in all @entity0 (in one case, @entity1 ; in four, persistent thymus; in 13, @entity7 ). The histological abnormalities were identical to those found in generalised @entity4 . This included the distribution of T-cell subtypes as identified by use of monoclonal antibodies. The severity of @entity3 was rated using a score developed for this purpose. The score progressively declined after surgery to an average of 70% of its initial amount in 80% of @entity0 . Full remission occurred in three cases. No @entity0 developed generalized @entity4 . Antibody titres against @entity2 receptors if elevated preoperatively also dropped following surgery, with one exception. Clear criteria for the expected therapeutic success of thymectomy could not be identified. Based on our results, and on the assumed significance of the thymus gland for pathogenesis, thymectomy should be considered in @entity0 with @entity3 .

title: Thymectomy in @entity4 with XXXX .

answer: @entity3


abstract: Eighteen @entity0 with exclusively @entity3 of @entity4 were thymectomised. @entity1 , resistance to @entity5 therapy or relapse following immunosuppressive therapy were taken as indications for surgery. The mean preoperative observation period before operation was 40 months, and after operation was 26 months. There was no operative or postoperative morbidity or mortality. @entity6 were found in all @entity0 (in one case, @entity1 ; in four, persistent thymus; in 13, @entity7 ). The histological abnormalities were identical to those found in generalised @entity4 . This included the distribution of T-cell subtypes as identified by use of monoclonal antibodies. The severity of @entity3 was rated using a score developed for this purpose. The score progressively declined after surgery to an average of 70% of its initial amount in 80% of @entity0 . Full remission occurred in three cases. No @entity0 developed generalized @entity4 . Antibody titres against @entity2 receptors if elevated preoperatively also dropped following surgery, with one exception. Clear criteria for the expected therapeutic success of thymectomy could not be identified. Based on our results, and on the assumed significance of the thymus gland for pathogenesis, thymectomy should be considered in @entity0 with @entity3 .

title: Thymectomy in XXXX with @entity3 .

answer: @entity4


abstract: AIMS: Persistent @entity2 ( @entity2 ) often recurs after direct current electrical cardioversion (ECV). As several experimental and clinical studies suggest that n-3 @entity3 ( @entity4 ) may have antiarrhythmic properties even at the atrial level, we aimed to evaluate whether oral supplementation with @entity4 , in addition to conventional antiarrhythmic drugs, could reduce the recurrence rate of the @entity1 after ECV of persistent @entity2 . METHODS AND RESULTS: Two hundred and four @entity0 (mean age 69.3 years, 33% females) with persistent @entity2 were randomly assigned to receive 3 g/day of @entity4 until ECV and 2 g/day thereafter (104 @entity0 ) or placebo (100 @entity0 ) for 6 months, beginning at least 1 week before ECV. Selection of conventional antiarrhythmic prophylaxis was left to local medical advice. The cardiac rhythm was assessed by both trans-telephonic monitoring and clinical visits. Primary end-point was the recurrence rate of @entity2 . Sinus rhythm was restored, either spontaneously or after ECV, in 187 @entity0 (91.7%); 95 @entity0 (91.4%) on @entity4 and 92 @entity0 (92.0%) on placebo (P=not significant). @entity2 relapsed in 56 (58.9%) of the @entity4 @entity0 and in 47 (51.1%) of the placebo @entity0 (P=0.28). The mean time to @entity2 recurrence was 83  8 days in the @entity4 group and 106  9 days in the placebo group (P=0.29). CONCLUSION: Our results do not support the hypothesis that, in @entity0 undergoing ECV of chronic persistent @entity2 , supplementation with @entity4 in addition to the usual antiarrhythmic treatment reduces recurrent @entity2 .

title: n-3 @entity3 for the prevention of XXXX recurrence after electrical cardioversion of chronic persistent @entity2 : a randomized, double-blind, multicentre study.

answer: @entity1


abstract: AIMS: Persistent @entity2 ( @entity2 ) often recurs after direct current electrical cardioversion (ECV). As several experimental and clinical studies suggest that n-3 @entity3 ( @entity4 ) may have antiarrhythmic properties even at the atrial level, we aimed to evaluate whether oral supplementation with @entity4 , in addition to conventional antiarrhythmic drugs, could reduce the recurrence rate of the @entity1 after ECV of persistent @entity2 . METHODS AND RESULTS: Two hundred and four @entity0 (mean age 69.3 years, 33% females) with persistent @entity2 were randomly assigned to receive 3 g/day of @entity4 until ECV and 2 g/day thereafter (104 @entity0 ) or placebo (100 @entity0 ) for 6 months, beginning at least 1 week before ECV. Selection of conventional antiarrhythmic prophylaxis was left to local medical advice. The cardiac rhythm was assessed by both trans-telephonic monitoring and clinical visits. Primary end-point was the recurrence rate of @entity2 . Sinus rhythm was restored, either spontaneously or after ECV, in 187 @entity0 (91.7%); 95 @entity0 (91.4%) on @entity4 and 92 @entity0 (92.0%) on placebo (P=not significant). @entity2 relapsed in 56 (58.9%) of the @entity4 @entity0 and in 47 (51.1%) of the placebo @entity0 (P=0.28). The mean time to @entity2 recurrence was 83  8 days in the @entity4 group and 106  9 days in the placebo group (P=0.29). CONCLUSION: Our results do not support the hypothesis that, in @entity0 undergoing ECV of chronic persistent @entity2 , supplementation with @entity4 in addition to the usual antiarrhythmic treatment reduces recurrent @entity2 .

title: n-3 @entity3 for the prevention of @entity1 recurrence after electrical cardioversion of chronic persistent XXXX : a randomized, double-blind, multicentre study.

answer: @entity2


abstract: AIMS: Persistent @entity2 ( @entity2 ) often recurs after direct current electrical cardioversion (ECV). As several experimental and clinical studies suggest that n-3 @entity3 ( @entity4 ) may have antiarrhythmic properties even at the atrial level, we aimed to evaluate whether oral supplementation with @entity4 , in addition to conventional antiarrhythmic drugs, could reduce the recurrence rate of the @entity1 after ECV of persistent @entity2 . METHODS AND RESULTS: Two hundred and four @entity0 (mean age 69.3 years, 33% females) with persistent @entity2 were randomly assigned to receive 3 g/day of @entity4 until ECV and 2 g/day thereafter (104 @entity0 ) or placebo (100 @entity0 ) for 6 months, beginning at least 1 week before ECV. Selection of conventional antiarrhythmic prophylaxis was left to local medical advice. The cardiac rhythm was assessed by both trans-telephonic monitoring and clinical visits. Primary end-point was the recurrence rate of @entity2 . Sinus rhythm was restored, either spontaneously or after ECV, in 187 @entity0 (91.7%); 95 @entity0 (91.4%) on @entity4 and 92 @entity0 (92.0%) on placebo (P=not significant). @entity2 relapsed in 56 (58.9%) of the @entity4 @entity0 and in 47 (51.1%) of the placebo @entity0 (P=0.28). The mean time to @entity2 recurrence was 83  8 days in the @entity4 group and 106  9 days in the placebo group (P=0.29). CONCLUSION: Our results do not support the hypothesis that, in @entity0 undergoing ECV of chronic persistent @entity2 , supplementation with @entity4 in addition to the usual antiarrhythmic treatment reduces recurrent @entity2 .

title: n-3 XXXX for the prevention of @entity1 recurrence after electrical cardioversion of chronic persistent @entity2 : a randomized, double-blind, multicentre study.

answer: @entity3


abstract: This study concerns 51 cases of cystic @entity4 of the @entity5 . At operation these @entity1 closely resembled @entity2 , presenting as a big cyst contiguous with the lateral ventricle and containing a small mural nodule. The nodule was in a deep location in 26 cases, and always showed marked contrast enhancement on computerized tomography scans. The most frequent presenting symptom was @entity3 (68%), and the most common sign was @entity6 (85%). The major goal of surgery was extirpation of the nodule. The follow-up period of the 34 cases available for long-term review ranged from 6 to 31 years (mean 17 years). Of these, 28 @entity0 (82%) had a good outcome; four (12%) had a fair result, and two (6%) had a poor response. An analysis of these results shows that total extirpation of the mural @entity1 was associated with the best outcome, whether or not the cyst wall was completely removed. Radiation therapy was irrelevant to the prognosis for these @entity0 . On the other hand, partial excision of the nodule, correlated with the deep location of the @entity1 , was the cause of the two poor results in this series and resulted in multiple operations for recurrences in two other @entity0 . Nevertheless, two of these @entity0 are still alive and well many years after incomplete surgical treatment. On the basis of this study, the importance of recognizing the occurrence of this "benign" @entity1 of the @entity5 is stressed, and the hypothesis of a common origin from subependymal glia of all @entity4 is supported.

title: Cystic XXXX of the @entity5 . Surgical experience with 51 cases and long-term results.

answer: @entity4


abstract: This study concerns 51 cases of cystic @entity4 of the @entity5 . At operation these @entity1 closely resembled @entity2 , presenting as a big cyst contiguous with the lateral ventricle and containing a small mural nodule. The nodule was in a deep location in 26 cases, and always showed marked contrast enhancement on computerized tomography scans. The most frequent presenting symptom was @entity3 (68%), and the most common sign was @entity6 (85%). The major goal of surgery was extirpation of the nodule. The follow-up period of the 34 cases available for long-term review ranged from 6 to 31 years (mean 17 years). Of these, 28 @entity0 (82%) had a good outcome; four (12%) had a fair result, and two (6%) had a poor response. An analysis of these results shows that total extirpation of the mural @entity1 was associated with the best outcome, whether or not the cyst wall was completely removed. Radiation therapy was irrelevant to the prognosis for these @entity0 . On the other hand, partial excision of the nodule, correlated with the deep location of the @entity1 , was the cause of the two poor results in this series and resulted in multiple operations for recurrences in two other @entity0 . Nevertheless, two of these @entity0 are still alive and well many years after incomplete surgical treatment. On the basis of this study, the importance of recognizing the occurrence of this "benign" @entity1 of the @entity5 is stressed, and the hypothesis of a common origin from subependymal glia of all @entity4 is supported.

title: Cystic @entity4 of the XXXX . Surgical experience with 51 cases and long-term results.

answer: @entity5


abstract: BACKGROUND AND OBJECTIVES: Ramucirumab is a fully immunoglobulin G (lgG) monoclonal antibody targeting @entity4 ( @entity4 ). Previous clinical trials suggested ramucirumab could improve the survival and increase the risk of adverse effects. Here, we aimed to assess the efficacy and safety of ramucirumab in the treatment of advanced solid @entity1 . METHODS: Publications were searched from Pubmed, Embase database and clinicaltrials.gov. Hazard ratio (HR) and 95  % confidence interval (95  % CI) were calculated to evaluate efficacy, and the risk ratio (RR) for adverse effects. RESULTS: Ten relevant studies were included. Ramucirumab resulted in significant benefit in overall survival [OS, HR and 95  % CI 0.87 (0.82-0.93), I (2): 0.0  %] and progression-free survival [PFS, HR and 95  % CI 0.74 (0.66-0.82), I (2): 67.4  %]. Also the difference of @entity7 ( @entity7 ) and objective response rate (ORR) between two groups were also significant [0.70 (0.57-0.88) and 1.78 (1.40-2.25), respectively]. Ramucirumab could increase the risk of total adverse effects (TAEs, of any grade) by 1  % (from 0 to 2  %) and severe adverse effects (SAEs, grade  >  2) by 17  % (from 9 to 26  %). The most frequently occurring TAEs were @entity8 (54.71  %), @entity9 (42.74  %), @entity6 (37.55  %), @entity5 (34.63  %) and @entity11 (33.74  %). Most frequently occurring SAEs (grade >= 3) were @entity9 (33.43  %), @entity8 (12.08  %), @entity10 (10.59  %), @entity3 (8.99  %) and @entity2 (8.74  %). CONCLUSION: Ramucirumab could improve OS and PFS for @entity0 suffering from advanced solid @entity1 . Ramucirumab could increase the risk of TAEs and SAEs.

title: The Impact of Ramucirumab on Survival in @entity0 with XXXX : A Systematic Review and Meta-Analysis of Randomized II/III Controlled Trials.

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: Ramucirumab is a fully immunoglobulin G (lgG) monoclonal antibody targeting @entity4 ( @entity4 ). Previous clinical trials suggested ramucirumab could improve the survival and increase the risk of adverse effects. Here, we aimed to assess the efficacy and safety of ramucirumab in the treatment of advanced solid @entity1 . METHODS: Publications were searched from Pubmed, Embase database and clinicaltrials.gov. Hazard ratio (HR) and 95  % confidence interval (95  % CI) were calculated to evaluate efficacy, and the risk ratio (RR) for adverse effects. RESULTS: Ten relevant studies were included. Ramucirumab resulted in significant benefit in overall survival [OS, HR and 95  % CI 0.87 (0.82-0.93), I (2): 0.0  %] and progression-free survival [PFS, HR and 95  % CI 0.74 (0.66-0.82), I (2): 67.4  %]. Also the difference of @entity7 ( @entity7 ) and objective response rate (ORR) between two groups were also significant [0.70 (0.57-0.88) and 1.78 (1.40-2.25), respectively]. Ramucirumab could increase the risk of total adverse effects (TAEs, of any grade) by 1  % (from 0 to 2  %) and severe adverse effects (SAEs, grade  >  2) by 17  % (from 9 to 26  %). The most frequently occurring TAEs were @entity8 (54.71  %), @entity9 (42.74  %), @entity6 (37.55  %), @entity5 (34.63  %) and @entity11 (33.74  %). Most frequently occurring SAEs (grade >= 3) were @entity9 (33.43  %), @entity8 (12.08  %), @entity10 (10.59  %), @entity3 (8.99  %) and @entity2 (8.74  %). CONCLUSION: Ramucirumab could improve OS and PFS for @entity0 suffering from advanced solid @entity1 . Ramucirumab could increase the risk of TAEs and SAEs.

title: The Impact of Ramucirumab on Survival in XXXX with @entity1 : A Systematic Review and Meta-Analysis of Randomized II/III Controlled Trials.

answer: @entity0


abstract: Changes in concentrations of minerals, trace elements, protein, @entity6 and total lipids during 20 mo of lactation and correlations between levels of these milk constituents were studied in a carefully defined set of 222 milk samples collected from 52 @entity0 , one-half of whom were vegetarians. Milk samples from vegetarians and those from nonvegetarians contained similar levels of @entity1 , @entity4 , @entity2 , @entity7 , @entity5 , @entity3 , @entity8 , @entity6 and fat. Following a brief but sharp initial decrease, levels of protein and @entity1 did not change significantly between mo 2 and 20 of lactation. Levels of @entity2 , @entity4 , @entity7 and @entity5 declined for the first 6 mo of lactation. Levels of lipid, @entity7 and @entity2 increased during later months of lactation while that of @entity3 decreased. Levels of @entity6 , @entity4 , @entity5 and @entity8 remained unchanged during mo 7-20. Stepwise multiple regression analysis showed positive correlations between levels of three pairs of inorganic constituents during the first 6 mo of lactation: @entity4 and @entity2 , @entity4 and @entity5 , and @entity5 and @entity3 . During the subsequent 14 mo of lactation, @entity5 was correlated with @entity4 . The level of @entity1 was positively correlated with that of lipid, while that of @entity3 was negatively correlated with that of lipid. These relationships, and others reported in the paper, are discussed in relation to current hypotheses of the mechanism of milk secretion and the binding of inorganic to organic milk constituents.

title: Inorganic constituents of breast milk from vegetarian and nonvegetarian XXXX : relationships with each other and with organic constituents.

answer: @entity0


abstract: OBJECTIVES: In this work, we examine the effects of stent-induced @entity3 on @entity1 and blood pressure using computational fluid dynamic simulations. BACKGROUND: Treatment of @entity2 ( @entity4 ) consists of either open, surgical repair or angioplasty with or without stenting. Although stenting is a minimally invasive alternative to surgery, @entity3 increases in the stented section. Concern over this increased stiffness has long been argued to be detrimental to the overall vascular health of the @entity0 . METHODS: MR imaging was performed on a 15-year-old female with @entity4 . A 3D model of the large thoracic arteries was created, and the heart and downstream vasculature were represented by lumped parameter models at the model inlet and outlets, respectively. A deformable wall assumption was used in conjunction with variable wall properties and tissue support, and 3D velocity, pressure, and wall dynamics were computed. The lumped parameter values and wall properties were tuned to match the mean flow and aortic deformation as measured by MRI. The @entity4 was then virtually removed from the model representing an end-to-end surgical correction. In a second model, the repaired section was prescribed to be nearly rigid, representing stenting. All other variables remained the same. RESULTS: When compared to surgery, stenting resulted in clinically negligible increases in cardiac work (0.4%) and no change in mean blood pressure. CONCLUSIONS: This pilot study suggests @entity4 stenting may not affect cardiac work to any significant degree as is commonly believed in the clinical community.

title: Computational fluid dynamic simulations of XXXX comparing the effects of surgical- and stent-based treatments on aortic compliance and ventricular workload.

answer: @entity2


abstract: BACKGROUND: Sleep disturbances (SDs) are common in @entity0 with all forms of @entity8 . However, most studies focus on @entity7 ( @entity7 ) and less is known about the prevalence and characteristics of @entity5 in @entity10 ( @entity10 ). OBJECTIVE: The aims of this cross-sectional study were: (1) to examine the frequency of @entity5 in @entity10 versus @entity7 ; (2) to compare @entity0 with and without @entity5 with regard to relevant clinical variables, and (3) to investigate the associations between @entity5 and medication use. METHODS: @entity0 with a first-time diagnosis of probable or possible @entity10 or @entity7 were selected from the @entity8 Study of Western Norway and recruited from clinics for old age psychiatry from 2010 until the end of 2013. RESULTS: In all, 123 (55.7%) subjects with @entity8 suffered from at least one @entity5 . @entity1 was present in 77 (34.8%), and 34 (20.7%) @entity0 had probable REM-sleep @entity3 (RBD). All SDs were also significantly more frequent in @entity0 with @entity10 than in @entity7 , and @entity10 @entity0 also more often had several co-occurring SDs. The presence of any @entity5 was associated with more @entity4 , higher morbidity, more @entity6 symptoms and excessive @entity2 . Antiparkinsonian medication was used more often in RBD, @entity11 ( @entity11 ) and periodic limb movements, and @entity9 were also common in @entity11 . CONCLUSIONS: Sleep problems are more common in @entity10 @entity0 compared to @entity7 , and are associated with more clinical impairment. @entity10 @entity0 frequently have several sleep problems occurring simultaneously, which suggests a need for screening and accurate assessment of sleep in @entity10 .

title: Higher Frequency and Complexity of Sleep Disturbances in @entity8 with Lewy Bodies as Compared to XXXX .

answer: @entity7


abstract: BACKGROUND: Sleep disturbances (SDs) are common in @entity0 with all forms of @entity8 . However, most studies focus on @entity7 ( @entity7 ) and less is known about the prevalence and characteristics of @entity5 in @entity10 ( @entity10 ). OBJECTIVE: The aims of this cross-sectional study were: (1) to examine the frequency of @entity5 in @entity10 versus @entity7 ; (2) to compare @entity0 with and without @entity5 with regard to relevant clinical variables, and (3) to investigate the associations between @entity5 and medication use. METHODS: @entity0 with a first-time diagnosis of probable or possible @entity10 or @entity7 were selected from the @entity8 Study of Western Norway and recruited from clinics for old age psychiatry from 2010 until the end of 2013. RESULTS: In all, 123 (55.7%) subjects with @entity8 suffered from at least one @entity5 . @entity1 was present in 77 (34.8%), and 34 (20.7%) @entity0 had probable REM-sleep @entity3 (RBD). All SDs were also significantly more frequent in @entity0 with @entity10 than in @entity7 , and @entity10 @entity0 also more often had several co-occurring SDs. The presence of any @entity5 was associated with more @entity4 , higher morbidity, more @entity6 symptoms and excessive @entity2 . Antiparkinsonian medication was used more often in RBD, @entity11 ( @entity11 ) and periodic limb movements, and @entity9 were also common in @entity11 . CONCLUSIONS: Sleep problems are more common in @entity10 @entity0 compared to @entity7 , and are associated with more clinical impairment. @entity10 @entity0 frequently have several sleep problems occurring simultaneously, which suggests a need for screening and accurate assessment of sleep in @entity10 .

title: Higher Frequency and Complexity of Sleep Disturbances in XXXX with Lewy Bodies as Compared to @entity7 .

answer: @entity8


abstract: BACKGROUND: @entity3 ( @entity3 ) is the most common infectious cause of @entity2 in the United States. To understand the effect of efforts to improve quality and efficiency of care in @entity3 , we examined the trends in mortality and costs among hospitalized @entity3 @entity0 . METHODS: Using the National Inpatient Sample between 1993 and 2005, we studied 569,524 @entity3 admissions. The primary outcome was mortality at discharge. We used logistic regression to evaluate the mortality trend, adjusting for age, gender, and comorbidities. To account for the effect of early discharge practices, we also compared daily mortality rates and performed a Cox proportional hazards model. We used a generalized linear model to analyze trends in hospitalization costs, which were derived using cost-to-charge ratios. RESULTS: Over time, length of stay declined, while more @entity0 were discharged to other facilities. The frequency of many comorbidities increased. Age/gender-adjusted mortality decreased from 8.9% to 4.1% (P < 0.001). In multivariable analysis, the mortality risk declined through 2005 (odds ratio, 0.50; 95% confidence interval, 0.48-0.53), compared with the reference year 1993. The daily mortality rates demonstrated that most of the mortality reduction occurred early during hospitalization. After adjusting for early discharge practices, the risk of mortality still declined through 2005 (hazard ratio, 0.74; 95% confidence interval, 0.70-0.78). Median hospitalization costs exhibited a moderate reduction over time, mostly because of reduced length of stay. CONCLUSIONS: Mortality among @entity0 hospitalized for @entity3 has declined. Lower in-hospital mortality at a reduced cost suggests that @entity1 is a case of improved productivity in health care.

title: Trends in mortality and medical spending in @entity0 hospitalized for community-acquired XXXX : 1993-2005.

answer: @entity1


abstract: BACKGROUND: @entity3 ( @entity3 ) is the most common infectious cause of @entity2 in the United States. To understand the effect of efforts to improve quality and efficiency of care in @entity3 , we examined the trends in mortality and costs among hospitalized @entity3 @entity0 . METHODS: Using the National Inpatient Sample between 1993 and 2005, we studied 569,524 @entity3 admissions. The primary outcome was mortality at discharge. We used logistic regression to evaluate the mortality trend, adjusting for age, gender, and comorbidities. To account for the effect of early discharge practices, we also compared daily mortality rates and performed a Cox proportional hazards model. We used a generalized linear model to analyze trends in hospitalization costs, which were derived using cost-to-charge ratios. RESULTS: Over time, length of stay declined, while more @entity0 were discharged to other facilities. The frequency of many comorbidities increased. Age/gender-adjusted mortality decreased from 8.9% to 4.1% (P < 0.001). In multivariable analysis, the mortality risk declined through 2005 (odds ratio, 0.50; 95% confidence interval, 0.48-0.53), compared with the reference year 1993. The daily mortality rates demonstrated that most of the mortality reduction occurred early during hospitalization. After adjusting for early discharge practices, the risk of mortality still declined through 2005 (hazard ratio, 0.74; 95% confidence interval, 0.70-0.78). Median hospitalization costs exhibited a moderate reduction over time, mostly because of reduced length of stay. CONCLUSIONS: Mortality among @entity0 hospitalized for @entity3 has declined. Lower in-hospital mortality at a reduced cost suggests that @entity1 is a case of improved productivity in health care.

title: Trends in mortality and medical spending in XXXX hospitalized for community-acquired @entity1 : 1993-2005.

answer: @entity0


abstract: BACKGROUND: @entity2 after sternotomy carries a very high mortality, especially in @entity0 receiving immunosuppressive treatment. METHODS: A retrospective analysis of the data for @entity0 who had undergone cardiopulmonary transplantation between May 1985 and December 2000 was undertaken. A total of 776 @entity0 had either a median sternotomy or a transverse sternotomy through a clam-shell incision. Transplantations were as follows: 591 heart (3 simultaneous heart and renal, and 1 heart and liver), 126 bilateral sequential lung, 57 heart-lung, 1 en bloc double-lung, and 1 heart and single-lung. RESULTS: In all, 21 (2.7%) recipients had @entity2 . Of these, 14 had heart, 3 heart-lung, and 4 bilateral lung transplantation. There were 18 median and 3 transverse sternotomies. There were 6 deaths (28.6%). Treatment consisted of antibiotics alone in 2 @entity0 and subxiphisternal drainage in another 2 @entity0 . The sternum was reopened in 17 (80.95%) @entity0 , with debridement and primary closure alone in 5 of these 17 @entity0 and additional irrigation in the other 12. Those who had resternotomy, debridement, and substernal irrigation had a better outcome when compared with the outcomes of other modes of treatment (1 @entity1 among 12 @entity0 ) (p = 0.06). Age, cardiopulmonary bypass time, body mass index, time to diagnosis, and treatment did not differ between those who survived and those who did not. CONCLUSIONS: Early aggressive debridement with substernal irrigation is the best mode of treatment for @entity0 with posttransplantation @entity2 .

title: XXXX in heart and lung transplantation: 15 years experience.

answer: @entity2


abstract: We report herein on a case strongly suspected of being @entity2 . A 22-year-old Indonesian @entity0 referred to our hospital presented with abnormal chest shadows upon medical examination. He had no symptoms. He did not have any pets nor did he eat raw beef or @entity4 . Hematological examination revealed @entity5 and elevation of @entity8 . Chest computed tomography revealed 3 pulmonary nodules with the halo sign. We suspected a parasite infection and performed antiparasite antibody testing. @entity9 was slightly positive on the screening test. As specific antibody against the larval excretory-secretory products of @entity7 , measured at the National Institute of @entity1 , was positive (level 3 up to 8). Subsequently, the abnormal chest shadows disappeared. However, two months later, 2 pulmonary nodules with the halo sign reappeared in other places. Diagnostic therapy with @entity6 was performed for 8 weeks. Mild @entity3 emerged during therapy, but it was within the allowed range. Thereafter, the results improved for the imaging findings, @entity5 , serum @entity8 level, and specific antibody. The antibody level became negative two months after the treatment had ended. We should consider @entity10 in the differential diagnosis of migratory nodular shadows with the halo sign on chest computed tomography, and immunoserological testing is useful for the diagnosis.

title: [A Case Strongly Suspected of Being XXXX Showing Multiple Pulmonary Nodules with a Disappearing and Reappearing Halo Sign].

answer: @entity2


abstract: The nature of the platelet response to osmotic shock and its relationship to platelet viability were studied. Light absorbancy changes of @entity0 platelet concentrates exposed to @entity3 were measured in a spectrophotometer: a sudden drop of light absorbancy was followed by a reversal of light absorbancy towards normal (reversal reaction). It was confirmed that the reversal reaction is a complex phenomenon dependent on the integrity of biochemical and enzymatic functions of the platelets. It was suppressed by glycolytic inhibitors and by SH-blocking agents. Ouabain had no immediate effect, but with prolonged incubation it depressed the reaction. Suspension of the platelets in a protein-free medium caused a rapid loss of the reversal reaction. Disappearance of the marginal bundle of microtubules by exposure to @entity5 did not change the reaction leading to the hypothesis that microfibrils rather than the microtubules may have been responsible for the reversal reaction. The conclusion was derived that the reversal reaction is due to cell volume contraction for which integrity of the platelet contractile protein and energy availability are essential. Platelet storage at 4 degrees C or at 22 degrees C caused a progressive @entity1 of the reversal reaction which was more severe in platelets preserved at 4 C than in those preserved at 22 degrees C, and paralleled the loss of the platelet capacity to survive in vivo. Cryoprotective agents ( @entity4 , @entity6 and @entity2 ) partially inhibited the reversal reaction. Freezing with these agents caused a more severe @entity1 of the reaction. The least @entity1 was observed with 5 per cent @entity4 . The results demonstrated that the reversal reaction is a valid and accurate in vitro indicator of in vivo platelet viability when the results to be compared are limited to a single method of storage. Usefulness of the reversal reaction is reduced when results obtained with different methods of storage are compared.

title: The platelet response to XXXX . Its value as an indicator of platelet viability after storage.

answer: @entity3


abstract: OBJECTIVES: The purpose of this study was to identify the most frequently encountered predisposing factors in relation to the etiology of @entity2 in young adults and to compare these findings with similar studies. METHOD AND MATERIALS: The @entity0 included in this prospective study were those presenting for treatment of signs and symptoms of @entity2 in the mandibular third molar area during an 8-year period from 1994 to 2001. A standard check sheet of subjective and objective observations was completed, and female @entity0 were asked about menstruation or pregnancy. Each @entity0 with a diagnosis of @entity2 was interviewed and observations were recorded. @entity0 were asked about the symptoms relating to the @entity2 . @entity0 were divided into five 5-year age groups ranging from 16 to 40 years. RESULTS: During the 8-year period, 2,151 @entity0 presented diagnosed cases of @entity2 ; 932 (43.3%) @entity0 were male and 1,219 (56.7%) were female. The peak age of occurrence of @entity2 varied from 21 to 25 years (55.2% of the @entity0 ). The incidence of @entity2 was highest in September (207 [9.6%]), followed by April (181 [8.4%]); for subacute @entity2 , the highest was in February (128 [5.95%]) and April (112 [5.2%]), followed by October (97 [4.5%]). The most frequently seen predisposing factor was @entity1 in 815 (37.9%) @entity0 , followed by stress in 473 (22%) @entity0 . CONCLUSION: It was concluded that the @entity1 was the most frequently predisposing factor, which could precipitate @entity2 .

title: The predisposing factors of XXXX of mandibular third molars in a Jordanian population.

answer: @entity2


abstract: PURPOSE: To assess the safety and effectiveness of a @entity5 ( @entity5 ) encapsulated @entity6 stents (Bard Peripheral Vascular, Tempe, AZ) for treatment of hemodialysis-related central @entity3 . MATERIALS AND METHODS: Study design was a single-center nonrandomized retrospective cohort of @entity0 from May 2004 to August 2009 for a total of 64 months. There were 14 @entity0 (mean age 60 years, range 50-83 years; 13 male, 1 female). All @entity0 had autogenous fistulas. All 14 @entity0 had central @entity3 and presented with clinical symptoms of the following: extremity swelling (14%, 2 of 14), extremity and face swelling (72%, 10 of 14), and face swelling/ @entity1 (14%, 2 of 14). There was evidence of @entity2 with decreased access flow in 36% (5 of 14) @entity0 . There were prior interventions or previous line placement at the site of the central @entity4 in all 14 @entity0 . Results were assessed by recurrence of clinical symptoms and function of the access circuit (National Kidney Foundation recommended criteria). RESULTS: Sixteen consecutive straight stent grafts were implanted in 14 @entity0 . Average treated lesion length was 5.0  cm (range, 0.9-7  cm). All 14 @entity0 had complete central @entity3 (100% stenosis). The central @entity3 were located as follows: right subclavian and brachiocephalic vein (21%, 3 of 14), right brachiocephalic vein (36%, 5 of 14), left brachiocephalic vein (36%, 5 of 14), and bilateral brachiocephalic vein (7%, 1 of 14). A total of 16 PTFE stent grafts were placed. Ten- or 12-mm-diameter PTFE stent grafts were placed. The average stent length was 6.1  cm (range, 4-8  cm). Technical (deployment), anatomic (<30% residual stenosis), clinical (resolution of symptoms), and hemodynamic (resolution of @entity2 ) success were 100%. At 3, 6, and 9  months, primary patency of the treated area and access circuit were 100% (14 of 14). CONCLUSIONS: This PTFE encapsulated stent graft demonstrates encouraging intermediate-term patency results for central vein occlusions. Further prospective studies with long-term assessment and larger @entity0 populations will be required.

title: Use of PTFE stent grafts for hemodialysis-related central XXXX : intermediate-term results.

answer: @entity3


abstract: The practice in the @entity1 division of Kitasato University East Hospital and Kitasato University Hospital has been emphasizing community psychiatry. The problems and proposed solutions are discussed. 1. Both hospitals are core hospitals located in Sagamihara City (Kanagawa Prefecture), which has no municipal hospital. 2. Kitasato University East Hospital has 94 beds in two closed wards and is one of the hospitals designated for @entity1 emergencies in Kanagawa Prefecture. 3. Over the last 10 years aroud Sagamihara City, cooperation between @entity1 hospitals and outpatient clinics, the treatment of @entity0 with mental and physical diseases, improvement of the quality of @entity1 practice, emergency psychiatry, and imbalances in the incomes and workloads of psychiatrists have been problematic. 4. Problems that need to be solved in practice to treat @entity2 involve inappropriate pharmacotherapy, disease mongering (the practice of widening the diagnostic boundaries of illnesses in order to expand the markets for drug treatment), clinical skills of psychiatrists, profitability, and medical institutions which cannot cope with regular @entity0 in an emergency. 5. Up to now, we have established a consulting service ("Second opinion" clinic) at Sagamihara Mental Health and Welfare Center (Municipal institution), recommended @entity0 ' consultation with family pharmacists, and increased the frequency of conferences for doctors without the support of pharmaceutical companies. 6. In order to develop community @entity1 services for @entity0 with @entity2 , the author is preparing a community-based critical path for @entity2 as well as community-based treatment network in the Sagamihara area. 7. The author believes that the urgent issue necessitates transparency and the increased visibility of @entity1 services.

title: [Practice of Community Psychiatry for the Treatment of XXXX ].

answer: @entity2


abstract: OBJECTIVE: To identify and describe voice, speech and @entity5 in @entity0 with Sj  @entity2 ( @entity2 ). MATERIALS AND METHODS: This was a prospective cross-sectional descriptive observational study. @entity0 with @entity2 were interviewed and physically explored. Nasolaryngeal endoscopy, video laryngeal stroboscopy, fiberoptic endoscopic evaluation of swallowing and computerized voice spectrographic analysis (PRAAT   software) of voice and speech were also performed. RESULTS: We included 31 @entity0 (96.7% @entity0 ). Average time of evolution was 5 years; mean age was 48.4 years. Of these @entity2 cases, 87% were secondary and 13% primary. Symptomatology: 70.9% @entity3 , 41.9% @entity6 , 35.4% dysglossia, 3.2% @entity4 . We found abnormalities principally in: one or more cranial nerves (V, VII, IX, X, XII) (67.7%), nasopharyngolaryngeal mucosa (77.4%), mucosal wave of vocal cords (90%), swallowing mechanism (90.3%), spectrogram of the vowels /e/ (58.06%) and /i/ (51.61%), and rhythm of the trisyllable "pataka" (35.48%). CONCLUSIONS: @entity0 with @entity2 have voice, speech and @entity5 , not only associated to xerosis, but perhaps also to @entity1 , probably secondary to the syndrome.

title: [Alterations in voice, speech and swallowing in XXXX with Sj  gren's syndrome].

answer: @entity0


abstract: INTRODUCTION: Reactive @entity2 species are a mediator of kidney damage by contrast media, and green tea is a potent-free radical scavenger. This study was designed to examine whether green tea could protect against the nephrotoxicity induced by contrast media. MATERIALS AND METHODS: Forty @entity3 were randomly divided into 4 groups. Group 1 was control; group 2 received contrast medium (intravenous @entity4 , 10 mL/kg, as a single dose); group 3 received contrast medium and then green tea extract for 3 days (10 mg/kg/d, intraperitoneal); and group 4 first received green tea and then contrast medium. Histological changes (degeneration, vacuolization of tubular renal cells, dilatation of tubular lumen, and presence of debris in the lumens) were assessed and recorded as scores from zero to 4. The sum of scores were used as the @entity1 level. RESULTS: Groups 3 and 4 with green tea treatment had significantly higher overall scores than the control group, but significantly lower scores than group 2 with contrast medium only. A similar trend was seen for dilatation and degeneration levels. Vacuolization level was not significantly lower in the green tea groups as compared to the contrast medium group. Debris level was not significantly lower in group 3 than group 2. The differences were not significant between groups 3 and 4.    Conclusions. We observed beneficial effect of green tea against nephrotoxicity of contrast media. Green tea extract may offer an inexpensive and nontoxic intervention strategy in @entity0 with a risk for nephrotoxicity with contrast media.

title: Ameliorative Effect of Green Tea Against Contrast-induced XXXX .

answer: @entity1


abstract: OBJECTIVE: To determine the prevalence of specific types of @entity3 ), and the association with possible risk factors, among female university students at university in Honduras. METHODS: In a cross-sectional study, cervical samples from 400 @entity0 aged 18-35years were tested using a Roche HPV linear array to differentiate 37 genotypes of HPV. Associations with risk factors were assessed. RESULTS: Of the 400 @entity0 , 393 completed the study. HPV DNA was detected in 45% of these @entity0 , of whom 73% were infected with high-risk types of HPV and 46% had @entity2 . Overall, 36 HPV genotypes were identified, of which HPV types 16, 51, 84, 66, and 39 were the most common. There was a marked decrease in the prevalence of multiple and high-risk infections with age. The factors that were independently associated with risk of being infected were related to @entity1 . CONCLUSION: The study showed that genital @entity4 is common among sexually active @entity0 at university in Honduras. In addition, the Roche linear array was shown to be a valuable tool for HPV genotyping, which will be useful for monitoring the future effectiveness of an HPV vaccine in the population.

title: Assessment of XXXX among female university students in Honduras via Roche linear array.

answer: @entity4


abstract: BACKGROUND: The addition of a chemotherapy drug or drugs to an established regimen is one method used to increase the dose and intensity of treatment for @entity0 . OBJECTIVES: To assess the effects of adding one or more chemotherapy drugs to an established regimen in @entity1 with @entity0 . SEARCH STRATEGY: We searched the Cochrane @entity0 Group's Specialised Register (to August 2009) using the codes for "advanced @entity0 " and "chemotherapy". This review is an update of the original Cochrane Review (Issue 3, 2006). SELECTION CRITERIA: Randomised trials with a first line regimen of at least two chemotherapy drugs compared to the same regimen plus the addition of one or more chemotherapy drugs in @entity1 with @entity0 . DATA COLLECTION AND ANALYSIS: Two authors extracted data independently from published trials. We derived hazard ratios (HR) from time-to-event outcomes where possible, and used a fixed-effect model for meta-analysis. We analysed response rates as dichotomous variables and extracted @entity3 data where available. MAIN RESULTS: We identified 17 trials reporting on 22 treatment comparisons (2674 @entity1 randomised). Fifteen trials (20 treatment comparisons) reported results for @entity2 response and 11 trials (14 treatment comparisons) published time-to-event data for overall survival. There were 1532 deaths in 2116 @entity1 randomised to trials of the addition of a drug to the regimen and control (the regimen alone). There was no detectable difference in overall survival between these @entity1 , with an overall HR of 0.96 (95% confidence interval (CI) 0.87 to 1.07, P = 0.47) and no significant heterogeneity. We found no difference in time to progression between these regimens, with an overall HR of 0.93 (95% CI 0.81 to 1.07, P = 0.31) and no significant heterogeneity. Addition of a drug to the regimen was favourably associated with @entity2 response rates (odds ratio 1.21, 95% CI 1.01 to 1.44, P = 0.04) although we observed significant heterogeneity for this outcome across the trials. Where measured, acute @entity3 such as @entity7 , @entity4 and @entity5 and @entity6 were more common with the addition of a drug. AUTHORS' CONCLUSIONS: The addition of one or more drugs to the regimen shows a statistically significant advantage for @entity2 response in @entity1 with @entity0 but the results suggest no difference in survival time or time to progression. The positive effect on @entity2 response was also associated with increased @entity3 .

title: Addition of drug/s to a chemotherapy regimen for XXXX .

answer: @entity0


abstract: OBJECTIVES: To examine the effect of L- and T/L-type @entity4 channel blockers on interstitial @entity2 in chronic unilateral ureteral obstruction (UUO). Tubulointerstitial @entity2 is a common outcome of several progressive @entity0 . @entity4 channel blockers are widely used for the treatment of @entity3 with @entity0 ; however, the direct effect of @entity4 channel blockers on @entity0 independent of lowering blood pressure has not been fully elucidated. METHODS: @entity1 were divided into 3 treatment groups: (1) vehicle control; (2) @entity5 , an L-type @entity4 channel blockers; and (3) @entity11 , a T/L-type @entity4 channel blockers. Treatment was initiated 1 day before and continued until 6 days after creation of the UUO. RESULTS: Tubulointerstitial @entity2 in the obstructed kidney was significantly increased compared with that in the contralateral unobstructed kidney. Furthermore, the increased @entity2 was accompanied by increased fibrogenic signaling expressed by transforming growth factor b1 and @entity7 mRNA levels, increased oxidative stress expressed by @entity12 , @entity9 and @entity8 mRNA level. Moreover, treatment with a nonhypotensive dose of @entity11 but not @entity5 in the obstructed kidney significantly suppressed the fibrogenic signaling and the oxidative stress, resulting in reduced tubulointerstitial @entity2 . The plasma @entity6 level in @entity11 -treated animals was increased compared with vehicle-treated animals, although not significantly. The increased plasma @entity6 level did not increase @entity10 mRNA level in @entity11 but not in @entity5 treated animals. CONCLUSIONS: Treatment with @entity11 improved tubulointerstitial @entity2 more effectively than treatment with @entity5 in UUO. The antifibrogenic effect by @entity11 was obtained through suppression of fibrogenic signaling.

title: Inhibitory effects of T/L-type @entity4 channel blockers on tubulointerstitial XXXX in obstructed kidneys in @entity1 .

answer: @entity2


abstract: OBJECTIVES: To examine the effect of L- and T/L-type @entity4 channel blockers on interstitial @entity2 in chronic unilateral ureteral obstruction (UUO). Tubulointerstitial @entity2 is a common outcome of several progressive @entity0 . @entity4 channel blockers are widely used for the treatment of @entity3 with @entity0 ; however, the direct effect of @entity4 channel blockers on @entity0 independent of lowering blood pressure has not been fully elucidated. METHODS: @entity1 were divided into 3 treatment groups: (1) vehicle control; (2) @entity5 , an L-type @entity4 channel blockers; and (3) @entity11 , a T/L-type @entity4 channel blockers. Treatment was initiated 1 day before and continued until 6 days after creation of the UUO. RESULTS: Tubulointerstitial @entity2 in the obstructed kidney was significantly increased compared with that in the contralateral unobstructed kidney. Furthermore, the increased @entity2 was accompanied by increased fibrogenic signaling expressed by transforming growth factor b1 and @entity7 mRNA levels, increased oxidative stress expressed by @entity12 , @entity9 and @entity8 mRNA level. Moreover, treatment with a nonhypotensive dose of @entity11 but not @entity5 in the obstructed kidney significantly suppressed the fibrogenic signaling and the oxidative stress, resulting in reduced tubulointerstitial @entity2 . The plasma @entity6 level in @entity11 -treated animals was increased compared with vehicle-treated animals, although not significantly. The increased plasma @entity6 level did not increase @entity10 mRNA level in @entity11 but not in @entity5 treated animals. CONCLUSIONS: Treatment with @entity11 improved tubulointerstitial @entity2 more effectively than treatment with @entity5 in UUO. The antifibrogenic effect by @entity11 was obtained through suppression of fibrogenic signaling.

title: Inhibitory effects of T/L-type XXXX channel blockers on tubulointerstitial @entity2 in obstructed kidneys in @entity1 .

answer: @entity4


abstract: OBJECTIVES: To examine the effect of L- and T/L-type @entity4 channel blockers on interstitial @entity2 in chronic unilateral ureteral obstruction (UUO). Tubulointerstitial @entity2 is a common outcome of several progressive @entity0 . @entity4 channel blockers are widely used for the treatment of @entity3 with @entity0 ; however, the direct effect of @entity4 channel blockers on @entity0 independent of lowering blood pressure has not been fully elucidated. METHODS: @entity1 were divided into 3 treatment groups: (1) vehicle control; (2) @entity5 , an L-type @entity4 channel blockers; and (3) @entity11 , a T/L-type @entity4 channel blockers. Treatment was initiated 1 day before and continued until 6 days after creation of the UUO. RESULTS: Tubulointerstitial @entity2 in the obstructed kidney was significantly increased compared with that in the contralateral unobstructed kidney. Furthermore, the increased @entity2 was accompanied by increased fibrogenic signaling expressed by transforming growth factor b1 and @entity7 mRNA levels, increased oxidative stress expressed by @entity12 , @entity9 and @entity8 mRNA level. Moreover, treatment with a nonhypotensive dose of @entity11 but not @entity5 in the obstructed kidney significantly suppressed the fibrogenic signaling and the oxidative stress, resulting in reduced tubulointerstitial @entity2 . The plasma @entity6 level in @entity11 -treated animals was increased compared with vehicle-treated animals, although not significantly. The increased plasma @entity6 level did not increase @entity10 mRNA level in @entity11 but not in @entity5 treated animals. CONCLUSIONS: Treatment with @entity11 improved tubulointerstitial @entity2 more effectively than treatment with @entity5 in UUO. The antifibrogenic effect by @entity11 was obtained through suppression of fibrogenic signaling.

title: Inhibitory effects of T/L-type @entity4 channel blockers on tubulointerstitial @entity2 in obstructed kidneys in XXXX .

answer: @entity1


abstract: PURPOSE: To investigate treatment outcome and prognostic factors after radiation therapy in @entity0 with @entity5 ( @entity5 ). METHODS AND MATERIALS: Sixty-six @entity0 with histologically confirmed @entity5 were treated at the University Hospital of Heidelberg between 1985 and 2009. Forty-two @entity0 (64%) were pediatric ( <= 18 years), and 24 @entity0 (36%) were adults. @entity1 resection was performed in all @entity0 and was complete in 47%. All @entity0 underwent postoperative craniospinal irradiation (CSI) delivering a median craniospinal dose of 35.5 Gy with additional boosts to the posterior fossa up to 54.0 Gy. Forty-seven @entity0 received chemotherapy, including 21 in whom chemotherapy was administered before CSI. Statistical analysis was performed using the log-rank test and the Kaplan-Meier method. RESULTS: Median follow-up was 93 months. @entity3 ( @entity3 ) and local and distant progression-free survival (LPFS and DPFS) were 73%, 62%, and 77% at 60 months. Both local and distant recurrence predisposed for significantly reduced @entity3 . Macroscopic complete tumor resection, desmoplastic histology and early initiation of postoperative radiation therapy within 28 days were associated with improved outcome. The addition of chemotherapy did not improve survival rates. @entity2 was moderate. CONCLUSIONS: Complete resection of @entity5 followed by CSI yields long survival rates in both @entity0 and adults. Delayed initiation of CSI is associated with poor outcome. @entity4 histology is associated with improved survival. The role of chemotherapy, especially in the adult population, must be further investigated in clinical studies.

title: Outcome and prognostic factors of radiation therapy for XXXX .

answer: @entity5


abstract: AIMS: Postural @entity1 (POTS) is associated with @entity1 on orthostasis. @entity0 frequently report palpitations, @entity2 , and @entity3 . Conventional therapy is effective in less than 60%. Case reports suggest @entity4 (a selective sinus node blocker, with no effect on blood pressure) may alleviate POTS-related symptoms. This is a retrospective case-series. METHODS AND RESULTS: Postural @entity1 @entity0 prescribed @entity4 were identified from the pharmacy database. Case notes were reviewed and @entity0 completed a symptom assessment tool. Twenty-two @entity0 were identified. Data were available from 20. Eight @entity0 reported reduced @entity1 and @entity3 and four reported only reduced @entity1 . The most common reason for discontinuing @entity4 was lack of efficacy (n = 6). Five @entity0 reported side-effects resulting in two discontinuing treatment. CONCLUSION: This retrospective case series indicates that 60% of @entity0 treated with @entity4 report a symptomatic improvement. A randomized controlled trial accessing the efficacy of @entity4 in POTS is indicated, particularly in @entity0 resistant to, or intolerant of, conventional therapy.

title: Single centre experience of XXXX in postural @entity1 .

answer: @entity4


abstract: AIMS: Postural @entity1 (POTS) is associated with @entity1 on orthostasis. @entity0 frequently report palpitations, @entity2 , and @entity3 . Conventional therapy is effective in less than 60%. Case reports suggest @entity4 (a selective sinus node blocker, with no effect on blood pressure) may alleviate POTS-related symptoms. This is a retrospective case-series. METHODS AND RESULTS: Postural @entity1 @entity0 prescribed @entity4 were identified from the pharmacy database. Case notes were reviewed and @entity0 completed a symptom assessment tool. Twenty-two @entity0 were identified. Data were available from 20. Eight @entity0 reported reduced @entity1 and @entity3 and four reported only reduced @entity1 . The most common reason for discontinuing @entity4 was lack of efficacy (n = 6). Five @entity0 reported side-effects resulting in two discontinuing treatment. CONCLUSION: This retrospective case series indicates that 60% of @entity0 treated with @entity4 report a symptomatic improvement. A randomized controlled trial accessing the efficacy of @entity4 in POTS is indicated, particularly in @entity0 resistant to, or intolerant of, conventional therapy.

title: Single centre experience of @entity4 in postural XXXX .

answer: @entity1


abstract: OBJECTIVE: To describe a new procedure for surgical correction of @entity3 with chordee. METHODS: The design of the urethral plate divide it in two flaps. Chordee must be resected in order to straighten the penis. Ventral side of neourethra is made with preputial skin or Mathieu procedure. This method has been used in 10 pediatric @entity0 diagnosed of @entity3 with chordee. RESULTS: Medium follow-up was 6 months. Only 2 @entity0 developed urethro-cutaneous fistulae and required a new surgical procedure. No reports of @entity2 , @entity1 or residual curvature were made. 8 @entity0 have excellent cosmetic results and 2 cases were classified as acceptable. CONCLUSIONS: This procedure is a new surgical method for correction of @entity3 with chordee.

title: [Use of a urethral plate in surgery for incurving XXXX ].

answer: @entity3


abstract: OBJECTIVE: Behaviors of @entity3 are different according to the geographic distribution. The prevalence of bone @entity2 in @entity0 with @entity3 has been shown to be between 40% and 90%, but clinical correlation is unknown. The aim of this study is to determine the rate of bone @entity2 in @entity0 with @entity3 in the northeast of Iran and its relationship with clinicopathologic findings of the @entity1 . METHODS: A total of 43 @entity0 with @entity3 , who were candidates for esophagectomy (without neo-adjuvant chemotherapy), were enrolled in this study from 2007 to 2009. Bone marrow samples derived from rib bone were stained with @entity6 and @entity7 (H_E) to distinguish tumoral cells, and cytokeratin immunohistochemistry (CKIHC) was used to determine micrometastasis. The correlation of the results was studied with the histopathologic indices of @entity1 ( @entity1 ( @entity1 ), N (node) and length of tumoral involvement and grading) as well as characteristics of the @entity0 (sex and age). RESULTS: The mean age was 64 (57-70) years and the M/F ratio was 2.9. As many as 38 @entity0 (88.4%) had @entity5 and five @entity0 (11.6%) had @entity4 . In nine cases (20.9%), the H_E test, and, in 13 cases (30.2%), the CKIHC evaluation was positive. Statistically, there was no relationship between the pathologic type and the stage of @entity1 with the H_E study and CKIHC test, respectively. On the other hand, a significant meaningful correlation was found between microscopic bone @entity2 as well as mediastinal lymph node involvement and grade of the @entity1 . CONCLUSION: Bone @entity2 incidence was low in our geographic area. According to our study, bone @entity2 in @entity3 is related to differentiation grade and mediastinal lymph node involvement.

title: Bone @entity2 in XXXX @entity0 who underwent surgical resection.

answer: @entity3


abstract: OBJECTIVE: Behaviors of @entity3 are different according to the geographic distribution. The prevalence of bone @entity2 in @entity0 with @entity3 has been shown to be between 40% and 90%, but clinical correlation is unknown. The aim of this study is to determine the rate of bone @entity2 in @entity0 with @entity3 in the northeast of Iran and its relationship with clinicopathologic findings of the @entity1 . METHODS: A total of 43 @entity0 with @entity3 , who were candidates for esophagectomy (without neo-adjuvant chemotherapy), were enrolled in this study from 2007 to 2009. Bone marrow samples derived from rib bone were stained with @entity6 and @entity7 (H_E) to distinguish tumoral cells, and cytokeratin immunohistochemistry (CKIHC) was used to determine micrometastasis. The correlation of the results was studied with the histopathologic indices of @entity1 ( @entity1 ( @entity1 ), N (node) and length of tumoral involvement and grading) as well as characteristics of the @entity0 (sex and age). RESULTS: The mean age was 64 (57-70) years and the M/F ratio was 2.9. As many as 38 @entity0 (88.4%) had @entity5 and five @entity0 (11.6%) had @entity4 . In nine cases (20.9%), the H_E test, and, in 13 cases (30.2%), the CKIHC evaluation was positive. Statistically, there was no relationship between the pathologic type and the stage of @entity1 with the H_E study and CKIHC test, respectively. On the other hand, a significant meaningful correlation was found between microscopic bone @entity2 as well as mediastinal lymph node involvement and grade of the @entity1 . CONCLUSION: Bone @entity2 incidence was low in our geographic area. According to our study, bone @entity2 in @entity3 is related to differentiation grade and mediastinal lymph node involvement.

title: Bone XXXX in @entity3 @entity0 who underwent surgical resection.

answer: @entity2


abstract: OBJECTIVE: Behaviors of @entity3 are different according to the geographic distribution. The prevalence of bone @entity2 in @entity0 with @entity3 has been shown to be between 40% and 90%, but clinical correlation is unknown. The aim of this study is to determine the rate of bone @entity2 in @entity0 with @entity3 in the northeast of Iran and its relationship with clinicopathologic findings of the @entity1 . METHODS: A total of 43 @entity0 with @entity3 , who were candidates for esophagectomy (without neo-adjuvant chemotherapy), were enrolled in this study from 2007 to 2009. Bone marrow samples derived from rib bone were stained with @entity6 and @entity7 (H_E) to distinguish tumoral cells, and cytokeratin immunohistochemistry (CKIHC) was used to determine micrometastasis. The correlation of the results was studied with the histopathologic indices of @entity1 ( @entity1 ( @entity1 ), N (node) and length of tumoral involvement and grading) as well as characteristics of the @entity0 (sex and age). RESULTS: The mean age was 64 (57-70) years and the M/F ratio was 2.9. As many as 38 @entity0 (88.4%) had @entity5 and five @entity0 (11.6%) had @entity4 . In nine cases (20.9%), the H_E test, and, in 13 cases (30.2%), the CKIHC evaluation was positive. Statistically, there was no relationship between the pathologic type and the stage of @entity1 with the H_E study and CKIHC test, respectively. On the other hand, a significant meaningful correlation was found between microscopic bone @entity2 as well as mediastinal lymph node involvement and grade of the @entity1 . CONCLUSION: Bone @entity2 incidence was low in our geographic area. According to our study, bone @entity2 in @entity3 is related to differentiation grade and mediastinal lymph node involvement.

title: Bone @entity2 in @entity3 XXXX who underwent surgical resection.

answer: @entity0


abstract: OBJECTIVES AND DESIGN: Traumatic thoracic aortic injuries are serious and may be associated with high morbidity and mortality. Endovascular stent grafting is now an established treatment option which often requires proximal landing zone extension through left subclavian artery (LSA) origin coverage. This in turn can lead to downstream ischaemic complications which may be lessened by LSA revascularisation. This study investigates the consequence of LSA coverage and potential benefit of revascularisation. MATERIALS AND METHODS: Systematic literature review of studies between 1997 and 2010 identified 94 studies incorporating 1704 @entity0 . Chronological trends in LSA management practice for @entity2 were sought. Designated outcomes of interest were prevalences of left arm ischaemia, @entity1 , @entity3 , @entity4 , stent migration, need for additional procedure and mortality. These outcomes were compared in @entity0 with and without LSA coverage (taking account of the degree of coverage). The impact of revascularisation on these outcomes was also explored. Statistical analysis included examination with Chi-Square or Fisher's tests as appropriate. RESULTS: Isolated total LSA coverage without revascularisation increases the prevalence of left arm ischaemia [prevalence of 4.06% versus 0.0% (p < 0.001)]; @entity1 [prevalence of 1.19% versus 0.23% (p = 0.025)]; and need for additional procedure [prevalence of 2.86% versus 0.86% (p = 0.004). In contrast there were no reported cases of @entity1 , @entity3 , @entity4 , stent migration or mortality when the LSA origin was only partially covered. When the LSA territory was revascularised, again no cases of left arm ischaemia, @entity1 , @entity3 , @entity4 , or mortality were reported. CONCLUSION: Current evidence suggests that LSA coverage in @entity0 undergoing endovascular stent grafting of the thoracic aorta for @entity2 should be avoided where possible to avoid ensuing downstream ischaemic complications. When coverage is anatomically necessary, partial coverage is better than complete in terms of avoiding these complications and revascularisation may be considered, however these decisions must be made in the context of the individual @entity0 scenario.

title: Management of the left subclavian artery during endovascular stent grafting for traumatic XXXX - a systematic review.

answer: @entity2


abstract: We report a rare case of primitive @entity13 / @entity8 ( @entity14 /ES) arising from the urinary bladder. A 65-year-old @entity0 presented with @entity5 and @entity11 . Computed tomography revealed an enlarged invasive @entity1 at the base of the bladder. No additional abnormal findings were disclosed by other diagnostic imaging methods. The surgical specimens showed small round cell @entity1 with positive staining for @entity10 gene product ( @entity10 ). EWS- @entity16 fusion transcripts were detected by reverse transcriptase polymerase chain reaction and direct sequencing, confirming the diagnosis of @entity14 /ES. The @entity0 developed swollen pelvic lymph nodes as well as multiple lung metastases at 8  months postoperatively. No effective results could be obtained even with systemic chemotherapy consisting of @entity7 , @entity6 , @entity3 and @entity9 (VIDE) based on the EUROpean @entity1 Working Initiative of National Groups 1999 ( @entity15 -E.W.I.N.G. 99) multinational trial. The @entity0 died of acute superior mesenteric artery @entity4 at 22  months postoperatively. @entity14 /ES could have been included in past cases of @entity12 because of the difficulty in its differential diagnosis. Exact diagnosis is crucial for deciding the treatment strategy for rare @entity2 consisting of small round cells.

title: Primitive XXXX /Ewing's sarcoma of the urinary bladder: a case report and its molecular diagnosis.

answer: @entity13


abstract: @entity17 is a rare disease characterized by @entity16 and anterior horn cell degeneration. The oldest reported @entity0 died at the age of 26 months. Two siblings were diagnosed with @entity17 after the @entity5 of the second sibling at 40 months of age from @entity8 and the unexpected finding of anterior horn cell degeneration on her autopsy. The older sibling was a @entity0 who was labeled as having @entity7 . He died at 14 months of age from @entity2 following a clinical course similar to his sister's, who was born 5 years after his @entity5 . Both siblings had significant @entity6 with axial and @entity9 initially. @entity9 with brisk reflexes developed later but were absent prior to @entity5 . Extensive investigations in the second sibling ruled out known metabolic (including @entity15 ) and @entity12 using skin fibroblast cultures and enzyme analysis. Genetic testing for @entity14 ; @entity1 , @entity10 , and @entity13 (NARP); @entity11 ; and @entity3 , 2, 3, 6, 7, and 8 gene abnormalities was negative. The elecroretinogram showed a previously unreported finding of abnormal and progressive rod/cone response. Our cases provide clinical and previously unreported electroretinographic evidence for @entity4 in @entity17 and call for the expansion of the disease phenotype.

title: XXXX : new leads for an earlier diagnosis.

answer: @entity17


abstract: INTRODUCTION: Light chain @entity3 is characterized by extracellular deposition of a fibrillar material derived from immunglobulin light chain fragments. AIM: The aim of the authors was to assess survival depending on cardiac involvement, therapy, and presence of @entity2 . METHOD: The authors studied a retrospective cohort of 29 @entity0 with light chain @entity3 (13 kappa, 16 lambda) treated in their institution between 2005 and 2014. RESULTS: Twenty-one @entity0 had @entity4 , while 8 had coexisting multiple @entity2 . One, two and three or more organs were involved in 4, 8, and 17 @entity0 , respectively. Cardiac involvement (22 cases) inversely correlated with survival. Fifteen (52%) @entity0 received chemotherapy only, while 14 (48%) underwent autologous stem cell transplantation with a median survival of 87 and 11.4 months, respectively. Two @entity0 had heart transplantation and survived 70 and 30 months. Median overall survival was 75.8 months. CONCLUSIONS: Cardiac transplantation followed by autologous stem cell transplantation is feasible in selected @entity0 with light chain @entity3 and @entity1 .

title: [Prognostic factors in light chain XXXX ].

answer: @entity3


abstract: Noroviruses (NoVs) are one of the leading causes of @entity5 in @entity0 and adults. For the last 2 decades, genogroup II genotype 4 (GII.4) NoVs have been circulating worldwide. GII.4 NoVs can be divided into variants, and since 2002 they have circulated in the population before being replaced every 2 or 3 years, which raises questions about the role of their histo-blood group antigen (HBGA) ligands in their evolution. To shed light on these questions, we performed an analysis of the interaction between representative GII.4 variants and HBGAs, and we determined the role of selected @entity2 in the binding profiles. By mutagenesis, we showed that there was a strict structural requirement for the @entity2 , directly implicated in interactions with HBGAs. However, the ablation of the @entity4 residue at position 395 (/\T395), an epidemiological feature of the post-2002 variants, was not deleterious to the binding of the virus-like particle (VLP) to the H antigen, while binding to A and B antigens was severely hampered. Nevertheless, the /\T395 VLPs gained the capacity to bind to the Lewis x and sialyl-Lewis x antigens in comparison with the wild-type VLP, demonstrating that @entity1 residues outside the HBGA binding site can modify the binding properties of NoVs. We also analyzed the attachment of baculovirus-expressed VLPs from six variants (Bristol, US95/96, Hunter, Yerseke, Den Haag, and Osaka) that were isolated from 1987 to 2007 to phenotyped saliva samples and synthetic HBGAs. We showed that the six variants could all attach to saliva of secretors irrespective of the ABO phenotype and to oligosaccharides characteristic of the secretor phenotype. Interestingly, Den Haag and Osaka variants additionally bound to @entity6 present in the saliva of Lewis-positive nonsecretors. The @entity3 binding profile and the genetic and mutagenesis analysis suggested that GII.4 binding to Lewis x and sialyl-Lewis x antigens might be a by-product of the genetic variation of the @entity2 located in the vicinity of the binding site. Analysis of the binding properties for the six variants by surface plasmon resonance showed that only post-2002 variants (i.e., Hunter, Yerseke, Den Haag, and Osaka) presented strong binding to A and B antigens, suggesting that the GII.4 evolution could be related to an increased affinity for HBGAs for the post-2002 variants. The combination of increased affinity for ABH antigens and of a newly acquired ability to recognize glycans from Lewis-positive nonsecretors could have contributed to the epidemiological importance of strains such as the Den Haag GII.4 subtype.

title: Qualitative and quantitative analysis of the binding of GII.4 norovirus variants onto XXXX blood group antigens.

answer: @entity0


abstract: One of the major challenges in the near future is the identification of genes that affect the metabolism of different drugs. Large scale association studies that utilise single nucleotide polymorphisms (SNPs) have been considered a valuable tool for this purpose. @entity4 , @entity1 , @entity3 , @entity5 and @entity2 were found to be involved in the majority of hepatically cleared drugs. To determine the allele frequencies of some SNPs that may have great potential value in forensic science, we screened 50 SNPs in these 5 CYP genes in Chinese Han @entity0 using an accurate, high-throughput, cost-effective method. Primers were designed using the MassARRAY Assay Design software. Genomic DNA was prepared from blood samples obtained from individuals of Chinese Han origin. Multiplex PCR was performed to amplify the relevant gene fragments, and the polymorphisms were analysed by allele-specific primer extension followed by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS). A panel of genomic DNA samples previously genotyped by other methods were analysed simultaneously for quality control, and the results demonstrated that this assay was 100% accurate. A total of 17 of the analysed SNPs were polymorphic. Of these 17 SNPs, 8 ( @entity8 , @entity9 , @entity10 , @entity11 , @entity7 , @entity12 , @entity13 , @entity6 ) had an allele frequency that was significantly different between this Chinese Han population and Caucasians (p<0.01). In addition, the frequencies of two of these SNPs ( @entity10 , @entity14 ) in our Chinese Han population differed significantly from the existing Chinese frequency data (p<0.01). The described method thus provides reliable results and enables the genotyping of up to thousands of samples by taking advantage of the high-throughput MALDI-TOF technology. The results herein are now included as a supplement to the P450 database.

title: Analysis of 50 SNPs in @entity4 , XXXX , @entity3 , @entity5 and @entity2 by MALDI-TOF mass spectrometry in Chinese Han population.

answer: @entity1


abstract: One of the major challenges in the near future is the identification of genes that affect the metabolism of different drugs. Large scale association studies that utilise single nucleotide polymorphisms (SNPs) have been considered a valuable tool for this purpose. @entity4 , @entity1 , @entity3 , @entity5 and @entity2 were found to be involved in the majority of hepatically cleared drugs. To determine the allele frequencies of some SNPs that may have great potential value in forensic science, we screened 50 SNPs in these 5 CYP genes in Chinese Han @entity0 using an accurate, high-throughput, cost-effective method. Primers were designed using the MassARRAY Assay Design software. Genomic DNA was prepared from blood samples obtained from individuals of Chinese Han origin. Multiplex PCR was performed to amplify the relevant gene fragments, and the polymorphisms were analysed by allele-specific primer extension followed by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS). A panel of genomic DNA samples previously genotyped by other methods were analysed simultaneously for quality control, and the results demonstrated that this assay was 100% accurate. A total of 17 of the analysed SNPs were polymorphic. Of these 17 SNPs, 8 ( @entity8 , @entity9 , @entity10 , @entity11 , @entity7 , @entity12 , @entity13 , @entity6 ) had an allele frequency that was significantly different between this Chinese Han population and Caucasians (p<0.01). In addition, the frequencies of two of these SNPs ( @entity10 , @entity14 ) in our Chinese Han population differed significantly from the existing Chinese frequency data (p<0.01). The described method thus provides reliable results and enables the genotyping of up to thousands of samples by taking advantage of the high-throughput MALDI-TOF technology. The results herein are now included as a supplement to the P450 database.

title: Analysis of 50 SNPs in @entity4 , @entity1 , XXXX , @entity5 and @entity2 by MALDI-TOF mass spectrometry in Chinese Han population.

answer: @entity3


abstract: One of the major challenges in the near future is the identification of genes that affect the metabolism of different drugs. Large scale association studies that utilise single nucleotide polymorphisms (SNPs) have been considered a valuable tool for this purpose. @entity4 , @entity1 , @entity3 , @entity5 and @entity2 were found to be involved in the majority of hepatically cleared drugs. To determine the allele frequencies of some SNPs that may have great potential value in forensic science, we screened 50 SNPs in these 5 CYP genes in Chinese Han @entity0 using an accurate, high-throughput, cost-effective method. Primers were designed using the MassARRAY Assay Design software. Genomic DNA was prepared from blood samples obtained from individuals of Chinese Han origin. Multiplex PCR was performed to amplify the relevant gene fragments, and the polymorphisms were analysed by allele-specific primer extension followed by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS). A panel of genomic DNA samples previously genotyped by other methods were analysed simultaneously for quality control, and the results demonstrated that this assay was 100% accurate. A total of 17 of the analysed SNPs were polymorphic. Of these 17 SNPs, 8 ( @entity8 , @entity9 , @entity10 , @entity11 , @entity7 , @entity12 , @entity13 , @entity6 ) had an allele frequency that was significantly different between this Chinese Han population and Caucasians (p<0.01). In addition, the frequencies of two of these SNPs ( @entity10 , @entity14 ) in our Chinese Han population differed significantly from the existing Chinese frequency data (p<0.01). The described method thus provides reliable results and enables the genotyping of up to thousands of samples by taking advantage of the high-throughput MALDI-TOF technology. The results herein are now included as a supplement to the P450 database.

title: Analysis of 50 SNPs in @entity4 , @entity1 , @entity3 , @entity5 and XXXX by MALDI-TOF mass spectrometry in Chinese Han population.

answer: @entity2


abstract: One of the major challenges in the near future is the identification of genes that affect the metabolism of different drugs. Large scale association studies that utilise single nucleotide polymorphisms (SNPs) have been considered a valuable tool for this purpose. @entity4 , @entity1 , @entity3 , @entity5 and @entity2 were found to be involved in the majority of hepatically cleared drugs. To determine the allele frequencies of some SNPs that may have great potential value in forensic science, we screened 50 SNPs in these 5 CYP genes in Chinese Han @entity0 using an accurate, high-throughput, cost-effective method. Primers were designed using the MassARRAY Assay Design software. Genomic DNA was prepared from blood samples obtained from individuals of Chinese Han origin. Multiplex PCR was performed to amplify the relevant gene fragments, and the polymorphisms were analysed by allele-specific primer extension followed by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS). A panel of genomic DNA samples previously genotyped by other methods were analysed simultaneously for quality control, and the results demonstrated that this assay was 100% accurate. A total of 17 of the analysed SNPs were polymorphic. Of these 17 SNPs, 8 ( @entity8 , @entity9 , @entity10 , @entity11 , @entity7 , @entity12 , @entity13 , @entity6 ) had an allele frequency that was significantly different between this Chinese Han population and Caucasians (p<0.01). In addition, the frequencies of two of these SNPs ( @entity10 , @entity14 ) in our Chinese Han population differed significantly from the existing Chinese frequency data (p<0.01). The described method thus provides reliable results and enables the genotyping of up to thousands of samples by taking advantage of the high-throughput MALDI-TOF technology. The results herein are now included as a supplement to the P450 database.

title: Analysis of 50 SNPs in XXXX , @entity1 , @entity3 , @entity5 and @entity2 by MALDI-TOF mass spectrometry in Chinese Han population.

answer: @entity4


abstract: One of the major challenges in the near future is the identification of genes that affect the metabolism of different drugs. Large scale association studies that utilise single nucleotide polymorphisms (SNPs) have been considered a valuable tool for this purpose. @entity4 , @entity1 , @entity3 , @entity5 and @entity2 were found to be involved in the majority of hepatically cleared drugs. To determine the allele frequencies of some SNPs that may have great potential value in forensic science, we screened 50 SNPs in these 5 CYP genes in Chinese Han @entity0 using an accurate, high-throughput, cost-effective method. Primers were designed using the MassARRAY Assay Design software. Genomic DNA was prepared from blood samples obtained from individuals of Chinese Han origin. Multiplex PCR was performed to amplify the relevant gene fragments, and the polymorphisms were analysed by allele-specific primer extension followed by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS). A panel of genomic DNA samples previously genotyped by other methods were analysed simultaneously for quality control, and the results demonstrated that this assay was 100% accurate. A total of 17 of the analysed SNPs were polymorphic. Of these 17 SNPs, 8 ( @entity8 , @entity9 , @entity10 , @entity11 , @entity7 , @entity12 , @entity13 , @entity6 ) had an allele frequency that was significantly different between this Chinese Han population and Caucasians (p<0.01). In addition, the frequencies of two of these SNPs ( @entity10 , @entity14 ) in our Chinese Han population differed significantly from the existing Chinese frequency data (p<0.01). The described method thus provides reliable results and enables the genotyping of up to thousands of samples by taking advantage of the high-throughput MALDI-TOF technology. The results herein are now included as a supplement to the P450 database.

title: Analysis of 50 SNPs in @entity4 , @entity1 , @entity3 , XXXX and @entity2 by MALDI-TOF mass spectrometry in Chinese Han population.

answer: @entity5


abstract: UNASSIGNED: @entity2 is a severe disease characterized by pathological mood swings from major @entity3 episodes to @entity2 . The biological underpinnings of @entity2 have yet to be defined. As a consequence, pharmacological treatments are suboptimal. In the present paper we test the hypothesis that the molecular pathways involved with the direct targets of @entity4 , hold significantly more genetic variations associated with @entity5 . A molecular pathway approach finds its rationale in the polygenic nature of the disease. The pathways were tested in a sample of    7000 @entity0 and controls. Data are available from the public NIMH database. The definition of the pathways was conducted according to the National @entity1 Institute (http://pid.nci.nih.gov/). As a result, 3 out of the 18 tested pathways related to @entity4 action resisted the permutation analysis and were found to be associated with @entity5 . These pathways were related to @entity6 , Integrins and Aurora. A pool of genes selected from the ones linked with the above pathways was further investigated in order to identify the fine molecular mechanics shared by our significant pathways and also their link with @entity4 mechanism of action. The data obtained point out to a possible involvement of microtubule-related mechanics.

title: The microtubule-associated molecular pathways may be genetically disrupted in @entity0 with XXXX . Insights from the molecular cascades.

answer: @entity2


abstract: UNASSIGNED: @entity2 is a severe disease characterized by pathological mood swings from major @entity3 episodes to @entity2 . The biological underpinnings of @entity2 have yet to be defined. As a consequence, pharmacological treatments are suboptimal. In the present paper we test the hypothesis that the molecular pathways involved with the direct targets of @entity4 , hold significantly more genetic variations associated with @entity5 . A molecular pathway approach finds its rationale in the polygenic nature of the disease. The pathways were tested in a sample of    7000 @entity0 and controls. Data are available from the public NIMH database. The definition of the pathways was conducted according to the National @entity1 Institute (http://pid.nci.nih.gov/). As a result, 3 out of the 18 tested pathways related to @entity4 action resisted the permutation analysis and were found to be associated with @entity5 . These pathways were related to @entity6 , Integrins and Aurora. A pool of genes selected from the ones linked with the above pathways was further investigated in order to identify the fine molecular mechanics shared by our significant pathways and also their link with @entity4 mechanism of action. The data obtained point out to a possible involvement of microtubule-related mechanics.

title: The microtubule-associated molecular pathways may be genetically disrupted in XXXX with @entity2 . Insights from the molecular cascades.

answer: @entity0