abstract: UNASSIGNED: Ebola zoonotic RNA filovirus represents @entity0 most virulent and lethal pathogens, which induces @entity6 and @entity1 within few days in a range of 60-90% of symptomatic individuals. Last outbreak in 2014 in West Africa caused panic that @entity5 can be spread to other continents. Number of deaths in late December reached almost 8,000 individuals out of more than 20,000 symptomatic @entity0 . It seems that only a coordinated international response could counteract the further spread of Ebola. Major innate immunity mechanisms against Ebola are associated with the production of interferons, that are inhibited by viral proteins. Activation of host NK cells was recognized as a leading immune function responsible for recovery of infected @entity0 . Uncontrolled cell infection by Ebola leads to an impairment of immunity with cytokine storm, @entity4 , @entity2 , @entity3 and @entity1 . Tested prevention strategies to induce antiviral immunity include: i. recombinant virus formulations (vaccines); ii. cocktail of monoclonal antibodies (serotherapy); iii. alternative RNA-interference-based antiviral methods. Maintaining the highest standards of aseptic and antiseptic precautions is equally important. Present brief review summarizes a current knowledge concerning pathogenesis of @entity2 and the virus interaction with the immune system and discusses recent advances in prevention of @entity5 by vaccination and serotherapy.

title: XXXX virus: pathogenesis, immune responses, potential prevention.

answer: @entity5


abstract: UNASSIGNED: Despite positive testing in animal studies, more than 80% of novel drug candidates fail to proof their efficacy when tested in @entity0 . This is primarily due to the use of preclinical models that are not able to recapitulate the physiological or pathological processes in @entity0 . Hence, one of the key challenges in the field of translational medicine is to "make the model organism @entity2 more @entity0 ". To get answers to questions that would be prognostic of outcomes in @entity0 medicine, the @entity2 's genome can be altered in order to create a more permissive host that allows the engraftment of @entity0 cell systems. It has been shown in the past that these strategies can improve our understanding of @entity1 immunology. However, the translational benefits of these platforms have still to be proven. In the 21(st) century, several research groups and consortia around the world take up the challenge to improve our understanding of how to humanize the animal's genetic code, its cells and, based on tissue engineering principles, its extracellular microenvironment, its tissues or entire organs with the ultimate goal to foster the translation of new therapeutic strategies from bench to bedside. The present article provides an overview of the state of the art of humanized models of @entity1 immunology and highlights future developments in the field such as the application of tissue engineering _ regenerative medicine (TE_RM) strategies to further enhance humanized @entity2 model systems. This article is protected by copyright. All rights reserved.

title: "Humanized Models of XXXX Immunology in the 21(st) Century: Convergence of @entity1 Research and Tissue Engineering"

answer: @entity1


abstract: UNASSIGNED: Despite positive testing in animal studies, more than 80% of novel drug candidates fail to proof their efficacy when tested in @entity0 . This is primarily due to the use of preclinical models that are not able to recapitulate the physiological or pathological processes in @entity0 . Hence, one of the key challenges in the field of translational medicine is to "make the model organism @entity2 more @entity0 ". To get answers to questions that would be prognostic of outcomes in @entity0 medicine, the @entity2 's genome can be altered in order to create a more permissive host that allows the engraftment of @entity0 cell systems. It has been shown in the past that these strategies can improve our understanding of @entity1 immunology. However, the translational benefits of these platforms have still to be proven. In the 21(st) century, several research groups and consortia around the world take up the challenge to improve our understanding of how to humanize the animal's genetic code, its cells and, based on tissue engineering principles, its extracellular microenvironment, its tissues or entire organs with the ultimate goal to foster the translation of new therapeutic strategies from bench to bedside. The present article provides an overview of the state of the art of humanized models of @entity1 immunology and highlights future developments in the field such as the application of tissue engineering _ regenerative medicine (TE_RM) strategies to further enhance humanized @entity2 model systems. This article is protected by copyright. All rights reserved.

title: "Humanized Models of @entity1 Immunology in the 21(st) Century: Convergence of XXXX Research and Tissue Engineering"

answer: @entity1


abstract: UNASSIGNED: The gills, or ctenidia, of marine gastropods serve as the sites for respiratory gas exchange. Cilia on the surface provide the pump that moves water through the mantle cavity and enhance diffusion. Because the gills are housed inside the shell, it is difficult to view them while they are functioning. Published images of gills show contracted, @entity0 that are distorted by the processes of dissection and preservation. Members of the families Fissurellidae (keyhole limpets) and Haliotidae (abalone) have openings in their shells through which water enters and/or exits. I inserted an endoscope connected to a video camera into the openings of the shells of living, non-anaesthetized individuals of the fissurellid @entity2 and the haliotid Haliotis rufescens. In both species, the dorsal afferent branchial vessel of the afferent gill @entity1 appeared large and inflated, as did the leaflets that extended from either side of the @entity1 . In @entity2 , the leaflets appeared to fill the mantle cavity and responded to touch, particles, and dye in the water by contracting quickly and slowly re-extending. In contrast, the gills of H. rufescens did not noticeably respond to disturbance. On the other hand, these gills showed a regular pattern of pleats that had not been described in the extensive anatomical literature of these common and economically significant animals. These results provide a novel view of the gastropod mantle cavity as a dynamic space filled by the gills, which divide the mantle cavity into distinct incurrent and excurrent chambers and produce a laminar flow of water through the cavity. J. Morphol., 2015.    2015 Wiley Periodicals, Inc.

title: Endoscopy of gastropods: A novel view of the mantle cavities and gills of the keyhole limpet XXXX and the abalone Haliotis rufescens.

answer: @entity2


abstract: Percutaneous recordings from more than one hundred single C fibres have been performed in the radial nerve of conscious @entity0 subjects. All these fibres belong to the poly-modal C nociceptor group, being excited by mechanical and thermal and also by chemical stimulation. Conduction velocities showed a monophasic distribution with a mean value of 0.86 m/s (SD: 0.17). The mechanical threshold, measured with von Frey hairs, varied between 2.3 and 13.1 g. The receptive field was circular or elliptical; for 33 units the mean axes were 6 mm and 7 mm. Mechanically evoked C fibre discharge even up to more than 10 spikes/s was not necessarily accompanied by @entity1 sensation. Nettle sting evoked an irregular C fibre discharge (maximum 10 spikes/s) accompanied by a pricking and burning sensation; the sensation of itch which was sometimes reported, was not correlated with the discharge frequency. C fibre activation by a chemical irritant (paint remover) also evoked an irregular discharge (maximum 3 to 6 spikes/s), accompanied by pricking and burning @entity1 sensation. The C threshold for radiant heat usually lay below the subject's @entity1 threshold. Increasing skin temperature produced increasing neural firing rate. The mean spike frequency rarely exceeded two spikes/s even with stimuli evoking strong @entity1 . The occurrence of subjective @entity1 response could be as well predicted from th C fibre spike frequency as from the skin temperature. It is concluded that nociceptive C input provoked by thermal or chemical stimuli correlates well with @entity1 sensation. However, similar C input provided by mechanical stimulation which activates also @entity2 mechanoreceptors, did not necessarily produce @entity1 sensation.

title: C nociceptor activity in XXXX nerve during painful and non painful skin stimulation.

answer: @entity0


abstract: UNASSIGNED: The aim of the present study was to provide quantitative data of oral function in healthy subjects (HSs), validity of measurements and estimation of measurement bias, as well as quantify @entity1 in @entity0 with @entity3 (SSc). 151 HSs and 12 subjects with SSc were recruited and assessed using instrumented tools, measuring @entity2 opening; lip strength; and tongue strength, protrusion, retraction, and endurance. Twenty HSs were also retested 3-5  weeks later in order to assess the test-retest reliability of the measurements. Intraclass correlation coefficients proved to be satisfactory (>0.8) for both inter-rater and test-retest reliabilities of all measurements except for tongue retraction. In the HS group, @entity2 opening and tongue and lips strength values were larger (P  <  0.05) for males than females, while no significant differences were found for other variables. Older subjects had statistically significantly lower tongue retraction values and tongue endurance values than younger subjects. The SSc group showed a statistically significant decrease (P  <  0.05) in almost all the measurements. Assessment procedures proved to be valid and reliable. Gender and height were predictors of mouth opening, lip and tongue strength, while age correlates with tongue retraction and endurance. Measurements highlighted the strong impact of SSc on oral functions and in particular on tongue protrusion, tongue strength, and endurance.

title: Instrumented Assessment of Oral Motor Function in Healthy Subjects and XXXX with Systemic Sclerosis.

answer: @entity0


abstract: @entity6 is a well-known @entity2 in the southwestern United States, and its occurrence is becoming more frequent in endemic areas. This disease can have a significant economic and medical impact; therefore, accurate diagnosis is crucial. In conjunction with @entity0 symptoms, residence in or travel to an endemic area is essential for diagnosis. Diagnosis is usually made with serology, culture, or biopsy and confirmed with DNA probe technology. @entity3 is the most common presentation and is seen in almost 95% of all cases. One-half to two-thirds of all @entity2 are asymptomatic or subclinical. Most @entity3 are self-limited and do not require treatment except in special populations. When treatment is warranted, @entity4 and @entity5 are frequently used. Diffuse @entity1 is uncommon and is especially rare in immunocompetent @entity0 . Herein we describe a rare presentation of @entity6 in a nonimmunocompromised @entity0 .

title: @entity6 with XXXX .

answer: @entity1


abstract: @entity6 is a well-known @entity2 in the southwestern United States, and its occurrence is becoming more frequent in endemic areas. This disease can have a significant economic and medical impact; therefore, accurate diagnosis is crucial. In conjunction with @entity0 symptoms, residence in or travel to an endemic area is essential for diagnosis. Diagnosis is usually made with serology, culture, or biopsy and confirmed with DNA probe technology. @entity3 is the most common presentation and is seen in almost 95% of all cases. One-half to two-thirds of all @entity2 are asymptomatic or subclinical. Most @entity3 are self-limited and do not require treatment except in special populations. When treatment is warranted, @entity4 and @entity5 are frequently used. Diffuse @entity1 is uncommon and is especially rare in immunocompetent @entity0 . Herein we describe a rare presentation of @entity6 in a nonimmunocompromised @entity0 .

title: XXXX with @entity1 .

answer: @entity6


abstract: UNASSIGNED: @entity7 is extremely rare. To investigate the clinical characteristics and further enrich the limited knowledge on its diagnosis and treatment, the present study retrospectively analyzed the detailed clinical data of five @entity0 with primary @entity4 treated in the Peking Union Medical College Hospital (Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China) between March 2009 and February 2014. The five @entity0 were female, aged from 16 to 51 years (mean, 36.0  16.3 years), with solitary lesions that were incidentally found on routine physical examinations. The @entity1 size ranged from 2.4 to 9.0 cm (mean, 6.0  2.7 cm). Ultrasonography revealed a mixed echo in four @entity0 , and computed tomography showed mixed density masses with fat components and calcification in three @entity0 . Adrenal-related endocrine tests were normal in all five @entity0 , and no abnormalities were found in the three @entity0 who underwent @entity6 receptor scintigraphy examination. All @entity0 were treated with retroperitoneal laparoscopic surgery, with no complications, and the resected @entity1 were identified as mature cystic @entity2 pathologically. To date, the @entity0 have been followed up for 4-60 months post-operatively, with no recurrence. In conclusion, this rare @entity4 is an occult entity to which reproductive females are susceptible. The @entity1 exhibits no typical clinical manifestations or adrenal-related @entity5 , and the pre-operative diagnosis mainly relies on imaging characteristics of a heterogeneous lesion containing fat components with scattered and marginal @entity3 . The preferred treatment is retroperitoneal laparoscopic surgery, and the prognosis is good.

title: XXXX : Clinical characteristics and retroperitoneal laparoscopic resection in five adults.

answer: @entity7


abstract: UNASSIGNED: The present study aimed to investigate the effects of blocking nuclear factor (NF)-kB and/or @entity4 ( @entity4 ) signaling pathways on proliferation and apoptosis of @entity1 cells in vitro. A375 @entity0 @entity1 cells were treated with @entity5 ( @entity4 signaling pathway inhibitor) and @entity6 (NF-kB inhibitor), alone or in combination. At 12, 24 and 48 h after treatment, cell viability was assessed using the @entity3 assay, cell cycle progression and apoptosis were evaluated by flow cytometry, and @entity2 protein content was determined by western blot analysis. @entity6 and @entity5 significantly inhibited A375 cell proliferation in a dose- and time-dependent manner (P<0.01). The rate of proliferation inhibition at 24 h was 35.41  1.38% for @entity6 alone, 30.64  2.86% for @entity5 alone, and 77.27  2.70% for @entity6 and @entity5 in combination. The difference between combination and single treatment was significantly different (P<0.01). The proportion of cells in S phase was 14.20, 18.40 and 22.64% following treatment with @entity6 , @entity5 , and @entity6 and @entity5 in combination, respectively; these values were all significantly reduced compared with the untreated control group (P<0.01). The apoptosis rate was 24.98  1.03% in the @entity6 group, 13.96  0.96% in the @entity5 group and 38.91  1.46% in the combination group; all significantly increased compared with the control group (P<0.01). @entity2 protein content in A375 cells was significantly increased following treatment with @entity6 and @entity5 , alone or in combination, when compared with the untreated control group (P<0.01). Therefore, NF-kB and @entity4 signaling pathway inhibitors may serve as potential therapeutic targets for @entity1 .

title: Effects of nuclear factor-kB and @entity4 signaling transduction pathway inhibitors on @entity0 XXXX cell proliferation in vitro.

answer: @entity1


abstract: UNASSIGNED: The present study aimed to investigate the effects of blocking nuclear factor (NF)-kB and/or @entity4 ( @entity4 ) signaling pathways on proliferation and apoptosis of @entity1 cells in vitro. A375 @entity0 @entity1 cells were treated with @entity5 ( @entity4 signaling pathway inhibitor) and @entity6 (NF-kB inhibitor), alone or in combination. At 12, 24 and 48 h after treatment, cell viability was assessed using the @entity3 assay, cell cycle progression and apoptosis were evaluated by flow cytometry, and @entity2 protein content was determined by western blot analysis. @entity6 and @entity5 significantly inhibited A375 cell proliferation in a dose- and time-dependent manner (P<0.01). The rate of proliferation inhibition at 24 h was 35.41  1.38% for @entity6 alone, 30.64  2.86% for @entity5 alone, and 77.27  2.70% for @entity6 and @entity5 in combination. The difference between combination and single treatment was significantly different (P<0.01). The proportion of cells in S phase was 14.20, 18.40 and 22.64% following treatment with @entity6 , @entity5 , and @entity6 and @entity5 in combination, respectively; these values were all significantly reduced compared with the untreated control group (P<0.01). The apoptosis rate was 24.98  1.03% in the @entity6 group, 13.96  0.96% in the @entity5 group and 38.91  1.46% in the combination group; all significantly increased compared with the control group (P<0.01). @entity2 protein content in A375 cells was significantly increased following treatment with @entity6 and @entity5 , alone or in combination, when compared with the untreated control group (P<0.01). Therefore, NF-kB and @entity4 signaling pathway inhibitors may serve as potential therapeutic targets for @entity1 .

title: Effects of nuclear factor-kB and XXXX signaling transduction pathway inhibitors on @entity0 @entity1 cell proliferation in vitro.

answer: @entity4


abstract: UNASSIGNED: The present study aimed to investigate the effects of blocking nuclear factor (NF)-kB and/or @entity4 ( @entity4 ) signaling pathways on proliferation and apoptosis of @entity1 cells in vitro. A375 @entity0 @entity1 cells were treated with @entity5 ( @entity4 signaling pathway inhibitor) and @entity6 (NF-kB inhibitor), alone or in combination. At 12, 24 and 48 h after treatment, cell viability was assessed using the @entity3 assay, cell cycle progression and apoptosis were evaluated by flow cytometry, and @entity2 protein content was determined by western blot analysis. @entity6 and @entity5 significantly inhibited A375 cell proliferation in a dose- and time-dependent manner (P<0.01). The rate of proliferation inhibition at 24 h was 35.41  1.38% for @entity6 alone, 30.64  2.86% for @entity5 alone, and 77.27  2.70% for @entity6 and @entity5 in combination. The difference between combination and single treatment was significantly different (P<0.01). The proportion of cells in S phase was 14.20, 18.40 and 22.64% following treatment with @entity6 , @entity5 , and @entity6 and @entity5 in combination, respectively; these values were all significantly reduced compared with the untreated control group (P<0.01). The apoptosis rate was 24.98  1.03% in the @entity6 group, 13.96  0.96% in the @entity5 group and 38.91  1.46% in the combination group; all significantly increased compared with the control group (P<0.01). @entity2 protein content in A375 cells was significantly increased following treatment with @entity6 and @entity5 , alone or in combination, when compared with the untreated control group (P<0.01). Therefore, NF-kB and @entity4 signaling pathway inhibitors may serve as potential therapeutic targets for @entity1 .

title: Effects of nuclear factor-kB and @entity4 signaling transduction pathway inhibitors on XXXX @entity1 cell proliferation in vitro.

answer: @entity0


abstract: Introduction   In @entity2 ( @entity2 ), caloric tests allow evaluation of @entity3 ( @entity3 ) and directional preponderance (DP), where different criteria of normality are adopted in Brazil and worldwide. The Brazilian version of the Dizziness Handicap Inventory (Brazilian DHI) evaluates the impact of @entity4 on the quality of life of an individual. Objectives   The objective of this research is to evaluate the impact of @entity4 on the quality of life of @entity0 undergoing @entity2 , and to relate these findings to the results obtained according to national and international criteria. Methods   Cross-sectional analytic study of 235 @entity0 referred for @entity2 in two hospitals. The authors performed the Brazilian DHI, history, static, and dynamic balance tests, positional @entity1 , and the Dix-Hallpike maneuver, as well as vectoelectronystagmography. Subjects were divided into three groups according to @entity3 and DP values. Descriptive statistics and comparisons between groups were performed, considering a significance level of 5% in all analyses. Results   @entity0 groups had 20.9% @entity0 , and 79.1% @entity0 . There was no significant difference between groups for the scores obtained in the Brazilian DHI. There was, however, a statistically significant difference in the redistribution of individuals according to the @entity3 and DP values. Conclusion   There was no relationship between @entity2 results and the impact of @entity4 in the quality of life. A review of normal values for @entity3 and DP adopted in Brazil is suggested, as well as the application of the Brazilian DHI as an additional tool to evaluate the impact of @entity4 on quality of life in all @entity0 undergoing @entity2 .

title: The Impact of Dizziness on the Quality of Life of 235 Individuals who Completed XXXX in Brazil.

answer: @entity2


abstract: UNASSIGNED: Understanding how @entity1 parasites gain entry into @entity0 red blood cells is essential for developing strategies to stop blood stage infection. @entity4 preferentially invades reticulocytes, which are immature red blood cells. The organism has two erythrocyte-binding protein families: namely, the Duffy-binding protein (PvDBP) and the reticulocyte-binding protein (PvRBP) families. Several members of the PvRBP family bind reticulocytes, specifically suggesting a role in mediating host cell selectivity of @entity4 . Here, we present, to our knowledge, the first high-resolution crystal structure of an erythrocyte-binding domain from PvRBP2a, solved at 2.12    resolution. The monomeric molecule consists of 10 a-helices and one short b-hairpin, and, although the structural fold is similar to that of PfRh5-the essential invasion ligand in @entity3 -its surface properties are distinct and provide a possible mechanism for recognition of alternate receptors. Sequence alignments of the crystallized fragment of PvRBP2a with other PvRBPs highlight the conserved placement of @entity2 bonds. PvRBP2a binds mature red blood cells through recognition of an erythrocyte receptor that is neuraminidase- and chymotrypsin-resistant but trypsin-sensitive. By examining the patterns of sequence diversity within field isolates, we have identified and mapped polymorphic residues to the PvRBP2a structure. Using mutagenesis, we have also defined the critical residues required for erythrocyte binding. Characterization of the structural features that govern functional erythrocyte binding for the PvRBP family provides a framework for generating new tools that block @entity4 blood stage infection.

title: Structurally conserved erythrocyte-binding domain in XXXX provides a versatile scaffold for alternate receptor engagement.

answer: @entity3


abstract: BACKGROUND: Disturbed circadian rhythms have been associated with @entity3 and @entity2 , but it is unclear if disturbances in the 24-hr activity rhythm and sleep are independently and specifically related to these disorders. METHODS: In 1,714 middle-aged and elderly @entity0 of the Rotterdam Study, we collected actigraphy recordings of at least 96 hr (138    14 hr, mean    standard deviation). Activity rhythms were quantified calculating the fragmentation of the rhythm, stability of the rhythm over days, and timing of the rhythm. Total sleep time, sleep onset latency, and wake after sleep onset were also estimated with actigraphy. @entity3 symptoms were assessed with the Center for Epidemiologic Studies @entity3 scale, @entity0 with clinically relevant @entity3 were interviewed to diagnose @entity3 . @entity2 were determined with the Munich version of the Composite International Diagnostic Interview. RESULTS: More fragmented rhythms were associated with clinically relevant @entity3 (odds ratio (OR): 1.27, 95% confidence interval (CI): 1.04;1.54) and @entity2 (OR: 1.39, 95% CI: 1.14;1.70) after covariate adjustment. Less stable rhythms, longer sleep onset latency, and more wake after sleep onset were related to clinically relevant @entity3 or @entity2 only if not adjusted for covariates and other activity rhythm and sleep indicators. CONCLUSIONS: Our study in middle-aged and elderly @entity0 suggests that fragmentation of the 24-hr activity rhythm is associated with @entity3 and @entity2 . Moreover, this association also largely accounts for the effect of disturbed sleep on these @entity1 .

title: 24-HOUR ACTIVITY RHYTHM AND SLEEP DISTURBANCES IN DEPRESSION AND ANXIETY: A POPULATION-BASED STUDY OF MIDDLE-AGED AND OLDER XXXX .

answer: @entity0


abstract: AIM: To validate the association between atypical endoscopic features and @entity2 ( @entity2 ). METHODS: A total of 247 @entity0 with @entity3 (NETs) were analyzed. Endoscopic images were reviewed independently by two endoscopists, each of whom classified @entity1 by sized and endoscopic features, such as shape, color, and surface change (kappa coefficient 0.76 for inter-observer agreement). All of @entity0 underwent computed tomography scans of abdomen and pelvis for evaluation of @entity2 . Univariate and multivariate analyses were performed to identify the factors associated with @entity2 . Additionally, the association between endoscopic atypical features and immunohistochemical staining of @entity1 was analyzed. RESULTS: Of 247 @entity0 , 156 (63.2%) were male and 15 (6.1%) were showed positive for @entity2 . On univariate analysis, @entity1 size (P < 0.001), shape (P < 0.001), color (P < 0.001) and surface changes (P < 0.001) were significantly associated with @entity2 . On multivariate analysis, @entity1 size (OR = 11.53, 95%CI: 2.51-52.93, P = 0.002) and atypical surface (OR = 27.44, 95%CI: 5.96-126.34, P < 0.001) changes were independent risk factors for @entity2 . The likelihood of atypical endoscopic features increased as @entity1 size increased. Atypical endoscopic features were associated with @entity2 in rectal NETs < 10 mm (P = 0.005) and 10-19 mm (P = 0.041) in diameter. Immunohistochemical staining showed that the rate of atypical endoscopic features was higher in non L-cell @entity1 . CONCLUSION: Atypical endoscopic features as well as @entity1 size are predictive factors of @entity2 in @entity0 with rectal NETs.

title: Clinical impact of atypical endoscopic features in XXXX .

answer: @entity3


abstract: AIM: To investigate the progression rate of small @entity2 and identify characteristics associated with their progression. METHODS: @entity0 with @entity2 with at least 1-year of follow-up were evaluated retrospectively. We excluded @entity0 with cysts larger than 3 cm or with features that were a concern for malignancy. In total, 135 @entity0 were evaluated. The interval progression of the cysts was examined. Characteristics were compared between @entity0 with and without progression. RESULTS: The @entity1 ranged from 3 to 29 mm. The mean follow-up period was 4.5    2.3 years and the mean progression rate was 1.0    1.3 mm/year. Ninety @entity0 showed interval progression and were divided into two groups; the minimal-change group (n = 41), who had cyst progression at less than 1 mm/year, and the progression group (n = 49), who had a progression rate of more than 1 mm/year. Compared with the cysts without progression, the lesions of the progression group were more frequently associated with tubular cyst, septation or a prominent pancreatic duct (P < 0.05). The odds ratio for progression was 5.318 for septation and 4.582 for tubular cysts. CONCLUSION: Small @entity1 progress slowly. Lesions with tubular shape, septa, or prominent pancreatic duct were more likely to progress, and required further diagnostic intervention or shorter surveillance interval.

title: Features associated with progression of small XXXX : A retrospective study.

answer: @entity2


abstract: UNASSIGNED: @entity4 ( @entity5 ) and @entity3 ( @entity3 ) have both been reported to induce adverse effects including immunotoxicity. Despite the widespread presence of these two chemicals in estuaries and seawater, their health effects on marine fish have received little attention. Oryzias melastigma is a potential marine fish model for immunological studies. In the present study, immune-related genes in O.  melastigma were enriched at the transcriptome level. Three-month-old fish were exposed to @entity5 and @entity3 (single or combined) for one week. The liver index-hepatosomatic index (HSI) of the fish was higher in the @entity5 -exposed group and combined group than in the control group. This result indicates that @entity5 might lead to liver @entity0 . The mRNA level of @entity1 ( @entity1 ) was upregulated after exposure. For catalase (CAT), @entity2 peroxidase (GPx) and cluster of differentiation 3 (CD3), single exposure did not affect mRNA levels, but the combined exposure did significantly alter the expression of these genes. In all, our study provides a useful reference for immunotoxicological studies with O.  melastigma; it also highlights the importance of assessing the combined effects of pollutant mixtures when determining the risk to aquatic organisms.

title: Immunotoxic effects of XXXX and @entity3 on the marine fish Oryzias melastigma.

answer: @entity4


abstract: UNASSIGNED: @entity4 ( @entity5 ) and @entity3 ( @entity3 ) have both been reported to induce adverse effects including immunotoxicity. Despite the widespread presence of these two chemicals in estuaries and seawater, their health effects on marine fish have received little attention. Oryzias melastigma is a potential marine fish model for immunological studies. In the present study, immune-related genes in O.  melastigma were enriched at the transcriptome level. Three-month-old fish were exposed to @entity5 and @entity3 (single or combined) for one week. The liver index-hepatosomatic index (HSI) of the fish was higher in the @entity5 -exposed group and combined group than in the control group. This result indicates that @entity5 might lead to liver @entity0 . The mRNA level of @entity1 ( @entity1 ) was upregulated after exposure. For catalase (CAT), @entity2 peroxidase (GPx) and cluster of differentiation 3 (CD3), single exposure did not affect mRNA levels, but the combined exposure did significantly alter the expression of these genes. In all, our study provides a useful reference for immunotoxicological studies with O.  melastigma; it also highlights the importance of assessing the combined effects of pollutant mixtures when determining the risk to aquatic organisms.

title: Immunotoxic effects of @entity4 and XXXX on the marine fish Oryzias melastigma.

answer: @entity3


abstract: BACKGROUND: Various parts of Pandanus foetidus Roxb. are used as traditional medicines. However, scientific reports concerning the effect of this plant on central nervous system (CNS) @entity3 and @entity6 are unavailable. This study investigated the CNS depressant and antinociceptive effects of Pandanus foetidus leaf extracts in a rodent model. METHODS: The sedative and anxiolytic activities of Pandanus foetidus extract (500 g) were tested using behavioural models of Swiss albino @entity0 , and the analgesic activity was assessed by @entity4 -induced @entity2 and tail immersion tests at 200 mg/kg body weight of the @entity0 . The data were analysed by a one-way ANOVA, a repeated measure of ANOVA and a non-parametric test (Kruskal-Wallis test) using the SPSS software. Acute @entity1 was tested using an established method. RESULTS: Compared with the aqueous fraction, the @entity5 , @entity10 and @entity9 fractions of the extract exhibited a more significant (P < 0.001) @entity8 in the @entity0 in the open field, hole-cross, and elevated plus maze (EPM). The @entity5 fraction maximized the duration of sleeping time caused by the thiopental @entity7 induction. The extract produced a significant step-down in @entity2 , as shown by the paw licking time in the early and late phases of the @entity4 test. In the tail immersion test, the @entity9 fraction maximally reduced the heat-induced @entity6 . The extract was found to be non toxic. CONCLUSION: The @entity5 , @entity10 , and @entity9 fractions of P. foetidus have strong CNS depressant and antinociceptive effects and thus merit further pharmaceutical studies.

title: CNS Depressant and Antinociceptive Effects of Different Fractions of Pandanus Foetidus Roxb. Leaf Extract in XXXX .

answer: @entity0


abstract: BACKGROUND: @entity3 ( @entity3 ) is a highly prevalent @entity2 that is associated with increased risk of @entity6 ( @entity6 ) and @entity7 . This study aimed to evaluate the correlation between the @entity3 and @entity8 ( @entity8 ) severity. METHODS: The cross-sectional study was conducted from September 2012 to December 2013. We enrolled 127 @entity0 with @entity9 who were referred for coronary angiographic studies in Shahid Chamran and Nour Hospitals in Isfahan, Iran. The Berlin questionnaire (BQ) was used for estimate the probability of @entity3 in @entity0 as a low or high probability. Demographic characteristics and metabolic risk factors including @entity1 , @entity6 , @entity4 , and smoking also were recorded. The severity of @entity8 was assessed and compared based on the Gensini score with Mann-Whitney U statistical test. Independent t-test for continuous variables and chi-square test for categorical variables were used. RESULTS: Totally, 65.4% of subjects were considered as high and 34.6% as low probability for @entity3 , which 81.1% of them had @entity8 . There was a significant difference between body mass index, systolic blood pressure, diastolic blood pressure, and @entity5 heart disease drug consumption with @entity3 probability (P < 0.0500). @entity8 was accompanied by @entity3 significantly (P = 0.0260). The Gensini score was significantly higher in @entity0 with high @entity3 probability (100.4    69.1 vs. 65.3    68.9; P = 0.0030). @entity3 also increase odds of @entity8 based on regression analysis (odds ratio, 95% confidence interval = 2.7). CONCLUSION: This study indicates that more severe @entity8 is associated with high @entity3 probability identified by BQ.

title: Obstructive sleep apnea, diagnosed by the Berlin questionnaire and association with XXXX severity.

answer: @entity8


abstract: BACKGROUND: It is critical to follow up @entity2 ( @entity2 ) after transcatheter arterial chemoembolization (TACE) in clinical practice. Computed tomography (CT) is used to assess @entity4 deposition, whereas it is difficult to @entity1 masked by @entity4 . In contrast, magnetic resonance imaging (MRI) is superior to CT in showing @entity1 , but cannot display @entity4 deposition. OBJECTIVES: The aim of this study was to investigate the value of spectral CT imaging in both @entity4 deposition and @entity1 for @entity2 @entity0 after TACE. @entity0 AND METHODS: Ten @entity2 @entity0 after treated with TACE underwent Discovery CT750 HD and MRI750 3T examination. Receiver operating characteristic (ROC) curves of @entity3 -based material decomposition images, monochromatic images and conventional CT images were generated. RESULTS: Consequently, 30 residual lesions were detected in MRI of 10 @entity0 . They were found in @entity3 -based images and monochromatic images versus 29 in conventional CT images. The area under ROC curves for the lesion-to-normal parenchyma ratio (LNR) on arterial phase (AP) in @entity3 -based material decomposition images, monochromatic images and conventional CT images were 0.933, 0.833 and 0.817, respectively. CONCLUSION: The study data highlighted good value of @entity3 -based material decomposition images of spectral CT in assessment of both @entity4 deposition and @entity1 for follow-up of @entity2 @entity0 previously treated with TACE.

title: Assessment of XXXX Deposition and @entity1 for @entity2 After Transcatheter Arterial Chemoembolization via @entity3 -Based Material Decomposition Images with Spectral Computed Tomography Imaging: A Preliminary Study.

answer: @entity4


abstract: BACKGROUND: It is critical to follow up @entity2 ( @entity2 ) after transcatheter arterial chemoembolization (TACE) in clinical practice. Computed tomography (CT) is used to assess @entity4 deposition, whereas it is difficult to @entity1 masked by @entity4 . In contrast, magnetic resonance imaging (MRI) is superior to CT in showing @entity1 , but cannot display @entity4 deposition. OBJECTIVES: The aim of this study was to investigate the value of spectral CT imaging in both @entity4 deposition and @entity1 for @entity2 @entity0 after TACE. @entity0 AND METHODS: Ten @entity2 @entity0 after treated with TACE underwent Discovery CT750 HD and MRI750 3T examination. Receiver operating characteristic (ROC) curves of @entity3 -based material decomposition images, monochromatic images and conventional CT images were generated. RESULTS: Consequently, 30 residual lesions were detected in MRI of 10 @entity0 . They were found in @entity3 -based images and monochromatic images versus 29 in conventional CT images. The area under ROC curves for the lesion-to-normal parenchyma ratio (LNR) on arterial phase (AP) in @entity3 -based material decomposition images, monochromatic images and conventional CT images were 0.933, 0.833 and 0.817, respectively. CONCLUSION: The study data highlighted good value of @entity3 -based material decomposition images of spectral CT in assessment of both @entity4 deposition and @entity1 for follow-up of @entity2 @entity0 previously treated with TACE.

title: Assessment of @entity4 Deposition and @entity1 for @entity2 After Transcatheter Arterial Chemoembolization via XXXX -Based Material Decomposition Images with Spectral Computed Tomography Imaging: A Preliminary Study.

answer: @entity3


abstract: BACKGROUND: It is critical to follow up @entity2 ( @entity2 ) after transcatheter arterial chemoembolization (TACE) in clinical practice. Computed tomography (CT) is used to assess @entity4 deposition, whereas it is difficult to @entity1 masked by @entity4 . In contrast, magnetic resonance imaging (MRI) is superior to CT in showing @entity1 , but cannot display @entity4 deposition. OBJECTIVES: The aim of this study was to investigate the value of spectral CT imaging in both @entity4 deposition and @entity1 for @entity2 @entity0 after TACE. @entity0 AND METHODS: Ten @entity2 @entity0 after treated with TACE underwent Discovery CT750 HD and MRI750 3T examination. Receiver operating characteristic (ROC) curves of @entity3 -based material decomposition images, monochromatic images and conventional CT images were generated. RESULTS: Consequently, 30 residual lesions were detected in MRI of 10 @entity0 . They were found in @entity3 -based images and monochromatic images versus 29 in conventional CT images. The area under ROC curves for the lesion-to-normal parenchyma ratio (LNR) on arterial phase (AP) in @entity3 -based material decomposition images, monochromatic images and conventional CT images were 0.933, 0.833 and 0.817, respectively. CONCLUSION: The study data highlighted good value of @entity3 -based material decomposition images of spectral CT in assessment of both @entity4 deposition and @entity1 for follow-up of @entity2 @entity0 previously treated with TACE.

title: Assessment of @entity4 Deposition and XXXX for @entity2 After Transcatheter Arterial Chemoembolization via @entity3 -Based Material Decomposition Images with Spectral Computed Tomography Imaging: A Preliminary Study.

answer: @entity1


abstract: BACKGROUND: It is critical to follow up @entity2 ( @entity2 ) after transcatheter arterial chemoembolization (TACE) in clinical practice. Computed tomography (CT) is used to assess @entity4 deposition, whereas it is difficult to @entity1 masked by @entity4 . In contrast, magnetic resonance imaging (MRI) is superior to CT in showing @entity1 , but cannot display @entity4 deposition. OBJECTIVES: The aim of this study was to investigate the value of spectral CT imaging in both @entity4 deposition and @entity1 for @entity2 @entity0 after TACE. @entity0 AND METHODS: Ten @entity2 @entity0 after treated with TACE underwent Discovery CT750 HD and MRI750 3T examination. Receiver operating characteristic (ROC) curves of @entity3 -based material decomposition images, monochromatic images and conventional CT images were generated. RESULTS: Consequently, 30 residual lesions were detected in MRI of 10 @entity0 . They were found in @entity3 -based images and monochromatic images versus 29 in conventional CT images. The area under ROC curves for the lesion-to-normal parenchyma ratio (LNR) on arterial phase (AP) in @entity3 -based material decomposition images, monochromatic images and conventional CT images were 0.933, 0.833 and 0.817, respectively. CONCLUSION: The study data highlighted good value of @entity3 -based material decomposition images of spectral CT in assessment of both @entity4 deposition and @entity1 for follow-up of @entity2 @entity0 previously treated with TACE.

title: Assessment of @entity4 Deposition and @entity1 for XXXX After Transcatheter Arterial Chemoembolization via @entity3 -Based Material Decomposition Images with Spectral Computed Tomography Imaging: A Preliminary Study.

answer: @entity2


abstract: Studies with selective lesions of cerebral structures have revealed the involvement of @entity1 in sleep and wakefulness. However, the mechanisms underlying the role of @entity1 remain obscure. An appreciation of the interrelationships between @entity1 and other transmitter systems might lead to a better understanding of the functions subserved by @entity1 . A serotoninergic projection from the median raph   nucleus to @entity2 neurons in the substantia nigra has been reported. We have therefore investigated the possible influence of the raph   system on the nigro striatal @entity2 pathway in the @entity0 using the "turning" model described by UNGERSTEDT (1971). An unilateral lesion in the median raph   nucleus induces contralateral turning similar to that observed following @entity3 administration to @entity0 with a unilaterally degenerated nigro striatal pathway. Similarly, unilateral application of 2.5 micrograms of @entity4 to the median raph   nucleus of normal @entity0 also provokes contralateral turning. On the other hand, unilateral injection of @entity4 into the zona compacta of the substantia nigra induces turning ipsilateral to the site of injection. The above results, and also those from several experiments in which @entity3 or @entity4 was applied systematically, suggest that @entity1 neurons in the median raph   nucleus exert an inhibitory influence on the dopaminergic nigro striatal system. These studies demonstrate that the serotoninergic median raph   system, in addition to its involvement in sleep and wakefulness, also exerts an important influence on motor functions.

title: [Involvement of serotoninergic mechanisms in the circling behaviour induced by XXXX and @entity4 in @entity0 (author's transl)].

answer: @entity3


abstract: Studies with selective lesions of cerebral structures have revealed the involvement of @entity1 in sleep and wakefulness. However, the mechanisms underlying the role of @entity1 remain obscure. An appreciation of the interrelationships between @entity1 and other transmitter systems might lead to a better understanding of the functions subserved by @entity1 . A serotoninergic projection from the median raph   nucleus to @entity2 neurons in the substantia nigra has been reported. We have therefore investigated the possible influence of the raph   system on the nigro striatal @entity2 pathway in the @entity0 using the "turning" model described by UNGERSTEDT (1971). An unilateral lesion in the median raph   nucleus induces contralateral turning similar to that observed following @entity3 administration to @entity0 with a unilaterally degenerated nigro striatal pathway. Similarly, unilateral application of 2.5 micrograms of @entity4 to the median raph   nucleus of normal @entity0 also provokes contralateral turning. On the other hand, unilateral injection of @entity4 into the zona compacta of the substantia nigra induces turning ipsilateral to the site of injection. The above results, and also those from several experiments in which @entity3 or @entity4 was applied systematically, suggest that @entity1 neurons in the median raph   nucleus exert an inhibitory influence on the dopaminergic nigro striatal system. These studies demonstrate that the serotoninergic median raph   system, in addition to its involvement in sleep and wakefulness, also exerts an important influence on motor functions.

title: [Involvement of serotoninergic mechanisms in the circling behaviour induced by @entity3 and XXXX in @entity0 (author's transl)].

answer: @entity4


abstract: Studies with selective lesions of cerebral structures have revealed the involvement of @entity1 in sleep and wakefulness. However, the mechanisms underlying the role of @entity1 remain obscure. An appreciation of the interrelationships between @entity1 and other transmitter systems might lead to a better understanding of the functions subserved by @entity1 . A serotoninergic projection from the median raph   nucleus to @entity2 neurons in the substantia nigra has been reported. We have therefore investigated the possible influence of the raph   system on the nigro striatal @entity2 pathway in the @entity0 using the "turning" model described by UNGERSTEDT (1971). An unilateral lesion in the median raph   nucleus induces contralateral turning similar to that observed following @entity3 administration to @entity0 with a unilaterally degenerated nigro striatal pathway. Similarly, unilateral application of 2.5 micrograms of @entity4 to the median raph   nucleus of normal @entity0 also provokes contralateral turning. On the other hand, unilateral injection of @entity4 into the zona compacta of the substantia nigra induces turning ipsilateral to the site of injection. The above results, and also those from several experiments in which @entity3 or @entity4 was applied systematically, suggest that @entity1 neurons in the median raph   nucleus exert an inhibitory influence on the dopaminergic nigro striatal system. These studies demonstrate that the serotoninergic median raph   system, in addition to its involvement in sleep and wakefulness, also exerts an important influence on motor functions.

title: [Involvement of serotoninergic mechanisms in the circling behaviour induced by @entity3 and @entity4 in XXXX (author's transl)].

answer: @entity0


abstract: UNASSIGNED: There are limited data to guide the choice of @entity1 ( @entity1 ) regimen before autologous hematopoietic cell transplantation (AHCT) for @entity0 with Hodgkin ( @entity5 ) and @entity6 ( @entity6 ). We studied 4917 @entity0 ( @entity6 , n  = 3905; @entity5 , n  = 1012) who underwent AHCT from 1995 to 2008 using the most common @entity1 platforms: carmustine (BCNU), etoposide, cytarabine, and melphalan (BEAM) (n  = 1730); cyclophosphamide, BCNU, and etoposide (CBV) (n  = 1853); busulfan and cyclophosphamide (BuCy) (n  = 789); and @entity2 ( @entity2 )-containing treatment (n  = 545). CBV was divided into CBV(high) and CBV(low) based on BCNU dose. We analyzed the impact of regimen on development of @entity3 ( @entity3 ), transplantation-related mortality (TRM), and progression-free and overall survival. The 1-year incidence of @entity3 was 3% to 6% and was highest in recipients of CBV(high) (hazard ratio [HR], 1.9) and @entity2 (HR, 2.0) compared with BEAM. One-year TRM was 4% to 8%, respectively, and was similar between regimens. Among @entity0 with @entity6 , there was a significant interaction between histology, @entity1 regimen, and outcome. Compared with BEAM, CBV(low) (HR, .63) was associated with lower mortality in @entity4 (P < .001), and CBV(high) (HR, 1.44) was associated with higher mortality in diffuse large B cell lymphoma (P  = .001). For @entity0 with @entity5 , CBV(high) (HR, 1.54), CBV(low) (HR, 1.53), BuCy (HR, 1.77), and @entity2 (HR, 3.39) were associated with higher mortality compared with BEAM (P < .001). The impact of specific AHCT regimen on post-transplantation survival is different depending on histology; therefore, further studies are required to define the best regimen for specific diseases.

title: Impact of Conditioning Regimen on Outcomes for @entity0 with XXXX Undergoing High-Dose Therapy with Autologous Hematopoietic Cell Transplantation.

answer: @entity4


abstract: UNASSIGNED: There are limited data to guide the choice of @entity1 ( @entity1 ) regimen before autologous hematopoietic cell transplantation (AHCT) for @entity0 with Hodgkin ( @entity5 ) and @entity6 ( @entity6 ). We studied 4917 @entity0 ( @entity6 , n  = 3905; @entity5 , n  = 1012) who underwent AHCT from 1995 to 2008 using the most common @entity1 platforms: carmustine (BCNU), etoposide, cytarabine, and melphalan (BEAM) (n  = 1730); cyclophosphamide, BCNU, and etoposide (CBV) (n  = 1853); busulfan and cyclophosphamide (BuCy) (n  = 789); and @entity2 ( @entity2 )-containing treatment (n  = 545). CBV was divided into CBV(high) and CBV(low) based on BCNU dose. We analyzed the impact of regimen on development of @entity3 ( @entity3 ), transplantation-related mortality (TRM), and progression-free and overall survival. The 1-year incidence of @entity3 was 3% to 6% and was highest in recipients of CBV(high) (hazard ratio [HR], 1.9) and @entity2 (HR, 2.0) compared with BEAM. One-year TRM was 4% to 8%, respectively, and was similar between regimens. Among @entity0 with @entity6 , there was a significant interaction between histology, @entity1 regimen, and outcome. Compared with BEAM, CBV(low) (HR, .63) was associated with lower mortality in @entity4 (P < .001), and CBV(high) (HR, 1.44) was associated with higher mortality in diffuse large B cell lymphoma (P  = .001). For @entity0 with @entity5 , CBV(high) (HR, 1.54), CBV(low) (HR, 1.53), BuCy (HR, 1.77), and @entity2 (HR, 3.39) were associated with higher mortality compared with BEAM (P < .001). The impact of specific AHCT regimen on post-transplantation survival is different depending on histology; therefore, further studies are required to define the best regimen for specific diseases.

title: Impact of Conditioning Regimen on Outcomes for XXXX with @entity4 Undergoing High-Dose Therapy with Autologous Hematopoietic Cell Transplantation.

answer: @entity0


abstract: Previous studies suggest that @entity9 / @entity5 (ara-C)/ @entity8 (IAP) is an active salvage regimen for @entity0 with @entity6 . We therefore investigated this regimen in @entity0 with newly-diagnosed @entity6 or @entity7 (>= 10% blasts). @entity0 were eligible if the anticipated treatment-related mortality (TRM) was <10%. @entity0 received @entity8 (1,280 mg/day po; days 1-8), @entity5 (1.5 g/m(2) /day; days 4-7), and @entity9 (12 mg/m(2) /day, days 4-6). Up to 3 cycles of consolidation with a shortened course was permitted. The primary endpoints were "good CR" rate (CR on day 35 without minimal @entity1 ) and TRM in the first 28 days. The study was to stop if after each cohort of 5 @entity0 (a) the Bayesian posterior probability was   <   5% that the true "good CR rate" was   >=    70% or (b) the posterior probability was >25% that the TRM rate was >= 5%. Twenty-four @entity0 were included. Conventional CR was achieved in 15 (63%) @entity0 but only 12 (50%) achieved "good CR". 4 of 12 (33%) @entity0 with "good CR" relapsed at median of 16 weeks (10.5-19). Five (21%) @entity0 had refractory disease. Survival probability at 1 year was 72% (48.7-64). Two (8.3%) @entity0 died within 28 days from @entity2 . The most common grade 3-4 adverse effects were @entity4 (75%) and @entity3 (25%). Based on the stopping rules accrual ceased after entry of these 24 @entity0 . IAP did not meet the predefined efficacy criteria for success. Therefore, we would not recommend this regimen for phase three testing in this @entity0 subset.

title: XXXX , @entity5 , and @entity8 as induction therapy for untreated @entity6 and high-risk myelodysplastic syndrome.

answer: @entity9


abstract: Previous studies suggest that @entity9 / @entity5 (ara-C)/ @entity8 (IAP) is an active salvage regimen for @entity0 with @entity6 . We therefore investigated this regimen in @entity0 with newly-diagnosed @entity6 or @entity7 (>= 10% blasts). @entity0 were eligible if the anticipated treatment-related mortality (TRM) was <10%. @entity0 received @entity8 (1,280 mg/day po; days 1-8), @entity5 (1.5 g/m(2) /day; days 4-7), and @entity9 (12 mg/m(2) /day, days 4-6). Up to 3 cycles of consolidation with a shortened course was permitted. The primary endpoints were "good CR" rate (CR on day 35 without minimal @entity1 ) and TRM in the first 28 days. The study was to stop if after each cohort of 5 @entity0 (a) the Bayesian posterior probability was   <   5% that the true "good CR rate" was   >=    70% or (b) the posterior probability was >25% that the TRM rate was >= 5%. Twenty-four @entity0 were included. Conventional CR was achieved in 15 (63%) @entity0 but only 12 (50%) achieved "good CR". 4 of 12 (33%) @entity0 with "good CR" relapsed at median of 16 weeks (10.5-19). Five (21%) @entity0 had refractory disease. Survival probability at 1 year was 72% (48.7-64). Two (8.3%) @entity0 died within 28 days from @entity2 . The most common grade 3-4 adverse effects were @entity4 (75%) and @entity3 (25%). Based on the stopping rules accrual ceased after entry of these 24 @entity0 . IAP did not meet the predefined efficacy criteria for success. Therefore, we would not recommend this regimen for phase three testing in this @entity0 subset.

title: @entity9 , XXXX , and @entity8 as induction therapy for untreated @entity6 and high-risk myelodysplastic syndrome.

answer: @entity5


abstract: Previous studies suggest that @entity9 / @entity5 (ara-C)/ @entity8 (IAP) is an active salvage regimen for @entity0 with @entity6 . We therefore investigated this regimen in @entity0 with newly-diagnosed @entity6 or @entity7 (>= 10% blasts). @entity0 were eligible if the anticipated treatment-related mortality (TRM) was <10%. @entity0 received @entity8 (1,280 mg/day po; days 1-8), @entity5 (1.5 g/m(2) /day; days 4-7), and @entity9 (12 mg/m(2) /day, days 4-6). Up to 3 cycles of consolidation with a shortened course was permitted. The primary endpoints were "good CR" rate (CR on day 35 without minimal @entity1 ) and TRM in the first 28 days. The study was to stop if after each cohort of 5 @entity0 (a) the Bayesian posterior probability was   <   5% that the true "good CR rate" was   >=    70% or (b) the posterior probability was >25% that the TRM rate was >= 5%. Twenty-four @entity0 were included. Conventional CR was achieved in 15 (63%) @entity0 but only 12 (50%) achieved "good CR". 4 of 12 (33%) @entity0 with "good CR" relapsed at median of 16 weeks (10.5-19). Five (21%) @entity0 had refractory disease. Survival probability at 1 year was 72% (48.7-64). Two (8.3%) @entity0 died within 28 days from @entity2 . The most common grade 3-4 adverse effects were @entity4 (75%) and @entity3 (25%). Based on the stopping rules accrual ceased after entry of these 24 @entity0 . IAP did not meet the predefined efficacy criteria for success. Therefore, we would not recommend this regimen for phase three testing in this @entity0 subset.

title: @entity9 , @entity5 , and @entity8 as induction therapy for untreated XXXX and high-risk myelodysplastic syndrome.

answer: @entity6


abstract: Previous studies suggest that @entity9 / @entity5 (ara-C)/ @entity8 (IAP) is an active salvage regimen for @entity0 with @entity6 . We therefore investigated this regimen in @entity0 with newly-diagnosed @entity6 or @entity7 (>= 10% blasts). @entity0 were eligible if the anticipated treatment-related mortality (TRM) was <10%. @entity0 received @entity8 (1,280 mg/day po; days 1-8), @entity5 (1.5 g/m(2) /day; days 4-7), and @entity9 (12 mg/m(2) /day, days 4-6). Up to 3 cycles of consolidation with a shortened course was permitted. The primary endpoints were "good CR" rate (CR on day 35 without minimal @entity1 ) and TRM in the first 28 days. The study was to stop if after each cohort of 5 @entity0 (a) the Bayesian posterior probability was   <   5% that the true "good CR rate" was   >=    70% or (b) the posterior probability was >25% that the TRM rate was >= 5%. Twenty-four @entity0 were included. Conventional CR was achieved in 15 (63%) @entity0 but only 12 (50%) achieved "good CR". 4 of 12 (33%) @entity0 with "good CR" relapsed at median of 16 weeks (10.5-19). Five (21%) @entity0 had refractory disease. Survival probability at 1 year was 72% (48.7-64). Two (8.3%) @entity0 died within 28 days from @entity2 . The most common grade 3-4 adverse effects were @entity4 (75%) and @entity3 (25%). Based on the stopping rules accrual ceased after entry of these 24 @entity0 . IAP did not meet the predefined efficacy criteria for success. Therefore, we would not recommend this regimen for phase three testing in this @entity0 subset.

title: @entity9 , @entity5 , and XXXX as induction therapy for untreated @entity6 and high-risk myelodysplastic syndrome.

answer: @entity8


abstract: UNASSIGNED: Sections of fecal cylinders were analyzed using fluorescence in situ hybridization targeting 180 bacterial groups. Samples were collected from three groups of @entity0 (N=20 each) treated for @entity4 with @entity3 + @entity2 . Group A only received the combined antibiotic regimen, whereas the A/Sb group received concomitant @entity1 boulardii CNCM I-745 treatment, and the A_Sb group received S. boulardii prophylaxis following the 14-day antibiotic course. The number of stool cylinders analyzed was 188 out of 228 in group A, 170 out of 228 in group A/Sb, and 172 out of 216 in group A_Sb. The colonic biomass was organized into a separate mucus layer with no bacteria, a 10-30 m broad unstirred transitional layer enriched with bacteria, and a patchy fermentative area that mixed digestive leftovers with bacteria. The antibiotics suppressed bacteria mainly in the fermentative area, whereas abundant bacterial clades retreated to the transitional mucus and survived. As a result, the total concentration of bacteria decreased only by one order. These effects were lasting, since the overall recovery of the microbial mass, bacterial diversity and concentrations were still below pre-antibiotic values 4 months after the end of antibiotic treatment. Sb-prophylaxis markedly reduced antibiotic effects and improved the recovery rates. Since the colon is a sophisticated bioreactor, the study indicated that the spatial anatomy of its biomass was crucial for its function.

title: Functional anatomy of the colonic bioreactor: Impact of antibiotics and XXXX boulardii on bacterial composition in @entity0 fecal cylinders.

answer: @entity1


abstract: UNASSIGNED: Sections of fecal cylinders were analyzed using fluorescence in situ hybridization targeting 180 bacterial groups. Samples were collected from three groups of @entity0 (N=20 each) treated for @entity4 with @entity3 + @entity2 . Group A only received the combined antibiotic regimen, whereas the A/Sb group received concomitant @entity1 boulardii CNCM I-745 treatment, and the A_Sb group received S. boulardii prophylaxis following the 14-day antibiotic course. The number of stool cylinders analyzed was 188 out of 228 in group A, 170 out of 228 in group A/Sb, and 172 out of 216 in group A_Sb. The colonic biomass was organized into a separate mucus layer with no bacteria, a 10-30 m broad unstirred transitional layer enriched with bacteria, and a patchy fermentative area that mixed digestive leftovers with bacteria. The antibiotics suppressed bacteria mainly in the fermentative area, whereas abundant bacterial clades retreated to the transitional mucus and survived. As a result, the total concentration of bacteria decreased only by one order. These effects were lasting, since the overall recovery of the microbial mass, bacterial diversity and concentrations were still below pre-antibiotic values 4 months after the end of antibiotic treatment. Sb-prophylaxis markedly reduced antibiotic effects and improved the recovery rates. Since the colon is a sophisticated bioreactor, the study indicated that the spatial anatomy of its biomass was crucial for its function.

title: Functional anatomy of the colonic bioreactor: Impact of antibiotics and @entity1 boulardii on bacterial composition in XXXX fecal cylinders.

answer: @entity0


abstract: PURPOSE: This study investigated the relationship between family composition and the prevalence of @entity1 by gender in Korean adults aged 45 years and older. METHODS: The sample consisted of 11,291 @entity0 in the Korea National Health and Nutrition Examination Survey from 2010 to 2012. We used complex sample analyses, including strata, cluster, and sample weighting, to allow generalization to the Korean population. Complex samples crosstabs and chi-square tests were conducted to compare the percentage of sociodemographic characteristics to the prevalence of @entity1 and its components by gender and family composition. Next, a complex sample logistic regression was performed to examine the association between family composition and the prevalence of @entity1 by gender. RESULTS: The percentage of adults living alone was 5.6% for @entity0 and 13.9% for @entity0 . Slightly more @entity0 (14.0%) than @entity0 (10.1%) reported living with three generations. The percentage of @entity1 in Korean adults aged 45 years and older was 53.2% for @entity0 and 35.7% for @entity0 . For @entity0 , we found that living with one or three generations was significantly associated with a higher risk of @entity1 , blood pressure, and @entity2 abnormality after adjusting for age, education, household income, smoking, physical activity, and body mass index, when compared to living alone. No significant relationships were found for @entity0 . CONCLUSIONS: A national strategy, tailored on gender and family composition, needs to be developed in order to prevent the increase of @entity1 in Korean @entity0 over middle age.

title: Association of Family Composition and XXXX in Korean Adults Aged over 45 Years Old.

answer: @entity1


abstract: BACKGROUND AND STUDY AIMS: Magnifying narrow-band imaging (NBI) is more useful than conventional endoscopy for diagnosing early @entity3 (EGC). However, evaluation of irregular microvascular patterns is subjective and is often difficult, even with expert eyes. The aim of this study was to clarify the most important microvascular patterns in magnifying NBI for diagnosis of EGC. @entity0 AND METHODS: This was a post-hoc analysis of a multicenter prospective trial among nine Japanese hospitals. A total of 1353 @entity0 underwent screening with white-light endoscopy and 362 @entity0 had small ( <=10mm) @entity2 . They were randomly assigned to magnifying NBI or white-light endoscopy followed by magnifying NBI. During diagnosis, magnifying NBI images were recorded before biopsy. All magnifying NBI images were reviewed and evaluated for the association of four features of microvessels - that is, dilation, tortuosity, difference in caliber, and variation in shape - with @entity1 diagnosis. RESULTS: Images of 343 lesions (40 cancerous and 303 benign @entity2 ) were evaluable. The diagnostic performance (sensitivity/specificity) of each finding was: dilation, 25/90%; tortuosity, 55/24%; difference in caliber, 13/99%; and variation in shape, 70/95%. Multivariate analysis identified only variation in shape as being statistically significantly associated with diagnosis of @entity1 (odds ratio 38.0, 95% confidence interval: 16.1-95.7, P<0.001). All findings showed moderate agreement (k values): dilation, 0.44; tortuosity, 0.33; difference in caliber, 0.26; and variation in shape, 0.48. CONCLUSIONS: A variation in shape was the most significant feature of microvessels observed in magnifying NBI for diagnosis of small depressed-type EGC. STUDY REGISTRATION: UMIN-CTR000001072.

title: A significant feature of microvessels in magnifying narrow-band imaging for diagnosis of early XXXX .

answer: @entity3


abstract: UNASSIGNED: The @entity4 reductase  M2 subunit ( @entity5 ) modulates the enzymatic activity of @entity4 reductase, and is involved in @entity1 progression. Recently, high levels of @entity5 expression were reported to correlate with poor survival outcomes in @entity0 with @entity2 . However, changes in @entity5 expression in @entity3 ( @entity3 ), and its effect on the prognosis of this disease remain unknown. The aim of the present study was to analyze the expression of @entity5 in @entity3 cell lines, and to identify whether @entity5 may serve as a biomarker with which to assess the prognosis of @entity3 . The present study found that @entity5 expression was higher in @entity3 cell lines and tissue samples than in noncancerous nasopharyngeal epithelial cell lines and noncancerous tissues, as shown by reverse transcription  -quantitative polymerase chain reaction analysis, western blotting and immunohistochemistry staining. Kaplan  -Meier survival analysis demonstrated that @entity0 with higher @entity5 expression levels had poorer disease  -free survival outcomes than those with lower expression levels of @entity5 . Univariate analysis showed that a lower survival rate was significantly associated with high @entity5 expression levels [hazard ratio (HR),  6.424; 95%  confidence interval  (CI),  2.381  -17.333; P<0.001]. Multivariate analysis indicated that @entity5 expression is an independent prognostic factor for @entity0 with @entity3 (HR, 3.461; 95 % CI, 1.204  -9.949; P=0.021). Overexpression of @entity5 led to increased cell proliferation, colony formation, migration and invasion in  vivo. These results suggest that high levels of @entity5 expression may be a useful predictor for survival in @entity0 with @entity3 and may serve as a novel prognostic indicator for these individuals.

title: @entity4 reductase  M2 subunit expression and prognostic value in XXXX .

answer: @entity3


abstract: UNASSIGNED: The @entity4 reductase  M2 subunit ( @entity5 ) modulates the enzymatic activity of @entity4 reductase, and is involved in @entity1 progression. Recently, high levels of @entity5 expression were reported to correlate with poor survival outcomes in @entity0 with @entity2 . However, changes in @entity5 expression in @entity3 ( @entity3 ), and its effect on the prognosis of this disease remain unknown. The aim of the present study was to analyze the expression of @entity5 in @entity3 cell lines, and to identify whether @entity5 may serve as a biomarker with which to assess the prognosis of @entity3 . The present study found that @entity5 expression was higher in @entity3 cell lines and tissue samples than in noncancerous nasopharyngeal epithelial cell lines and noncancerous tissues, as shown by reverse transcription  -quantitative polymerase chain reaction analysis, western blotting and immunohistochemistry staining. Kaplan  -Meier survival analysis demonstrated that @entity0 with higher @entity5 expression levels had poorer disease  -free survival outcomes than those with lower expression levels of @entity5 . Univariate analysis showed that a lower survival rate was significantly associated with high @entity5 expression levels [hazard ratio (HR),  6.424; 95%  confidence interval  (CI),  2.381  -17.333; P<0.001]. Multivariate analysis indicated that @entity5 expression is an independent prognostic factor for @entity0 with @entity3 (HR, 3.461; 95 % CI, 1.204  -9.949; P=0.021). Overexpression of @entity5 led to increased cell proliferation, colony formation, migration and invasion in  vivo. These results suggest that high levels of @entity5 expression may be a useful predictor for survival in @entity0 with @entity3 and may serve as a novel prognostic indicator for these individuals.

title: XXXX reductase  M2 subunit expression and prognostic value in @entity3 .

answer: @entity4


abstract: Hepatic stellate cells (HSCs) play an important role in liver @entity3 and @entity4 . This study established a new @entity2 HSC cell line LSC-1. Liver ex vivo perfusion with collagenase IV and density gradient centrifugation were used to isolate @entity2 HSC. Cells have been maintained in culture for multiple passages. LSC-1 cell biological characteristics were studied. LSC-1 cell have been maintained in culture over 100 passages. This new HSC cell line express telomerase reverse transcriptase (TRT) and @entity9 , suggesting that it is immortalized spontaneously. LSC-1 cells have a doubling time of 46 hours and their growth is serum-dependent. Karyotypic analysis revealed that LSC-1 cells possess normal chromosome phenotype. Moreover, LSC-1 cells do not grow in soft agar or induce @entity0 in @entity1 , suggesting that they are not transformed. LSC-1 cells express desmin, glial fibrillary acidic proteins (GFAP), collagen type I and III, a-smooth muscle actin (a-SMA), @entity7 ( @entity7 ), @entity5 ( @entity5 ) and inducible @entity6 synthase (iNOS). @entity7 stimulation increased collagen type I and III expression in LSC-1 cells. Additionally, LSC-1 cells proliferate in response to PDGF-BB, and contract in response to @entity8 (ET-1). In summary, LSC-1 cells exhibit activated HSC phenotype characteristics, and therefore are useful tool to study the pathogenesis of liver @entity3 and @entity4 .

title: Establishment and characterization of an immortalized XXXX hepatic stellate cell line.

answer: @entity2


abstract: OBJECTIVES:: We aim to characterize a group of @entity0 with eosinophilic @entity8 with @entity8 (EGPA) with an initial presentation of @entity7 . METHODS:: A retrospective analysis of 11 @entity0 with EGPA. RESULTS:: The most common chief complaint was @entity1 and @entity5 (100%), followed by @entity3 (82%). Nine (82%) @entity0 had acute to subacute onset. All @entity0 had a history of @entity4 and serum @entity6 of more than 11%. Combining clinical and electrophysiological data, 10 (91%) @entity0 demonstrated notable asymmetric involvement, whereas 1 @entity0 presented with a length-dependent symmetrical axonal @entity2 . All @entity0 improved significantly after immunotherapy, with average time to improvement of 9 weeks. Ten (91%) @entity0 improved steadily and experienced no relapse, whereas 1 relapsed within the first year. CONCLUSIONS:: EGPA should be suspected in @entity0 with asymmetric @entity7 associated with @entity4 and @entity6 . Early diagnosis and aggressive treatment help to achieve favorable outcome.

title: Eosinophilic Granulomatosis With @entity8 (Churg-Strauss Syndrome) Presenting With XXXX -A Case Series.

answer: @entity2


abstract: OBJECTIVES:: We aim to characterize a group of @entity0 with eosinophilic @entity8 with @entity8 (EGPA) with an initial presentation of @entity7 . METHODS:: A retrospective analysis of 11 @entity0 with EGPA. RESULTS:: The most common chief complaint was @entity1 and @entity5 (100%), followed by @entity3 (82%). Nine (82%) @entity0 had acute to subacute onset. All @entity0 had a history of @entity4 and serum @entity6 of more than 11%. Combining clinical and electrophysiological data, 10 (91%) @entity0 demonstrated notable asymmetric involvement, whereas 1 @entity0 presented with a length-dependent symmetrical axonal @entity2 . All @entity0 improved significantly after immunotherapy, with average time to improvement of 9 weeks. Ten (91%) @entity0 improved steadily and experienced no relapse, whereas 1 relapsed within the first year. CONCLUSIONS:: EGPA should be suspected in @entity0 with asymmetric @entity7 associated with @entity4 and @entity6 . Early diagnosis and aggressive treatment help to achieve favorable outcome.

title: Eosinophilic Granulomatosis With XXXX (Churg-Strauss Syndrome) Presenting With @entity2 -A Case Series.

answer: @entity8


abstract: @entity0 caused by nervous system @entity3 . The pathogenesis and the mechanism underlying @entity0 remains unclear. The only known neurobiological component involved in the @entity0 is @entity5 (NO). NO is synthesized by @entity5 synthase ( @entity7 ) from @entity8 and @entity1 . @entity7 is involved in the @entity4 and @entity0 . In this study, we aimed to identify whether @entity9 reduced the @entity4 in the @entity2 . Sixty adult male SD @entity2 were randomly divided into 4 groups. Sham group and model group were not received treatment. Experimental group received intrathecal injection of @entity9 , and negative control group received @entity6 injection 30 min before @entity4 test. After last test of @entity4 threshold, the @entity2 were sacrificed and lumbar spinal tissues were sampled for analysis of the expression of pnNOS and pCaMK II by quantitative PCR and Western blotting. @entity4 threshold was increased in the @entity2 received @entity9 treatment (P<0.01), and the expression levels of pnNOS was increased (P<0.05) in experimental group and accompanied with decrease of CaMK II expression (P<0.05). By administration of @entity9 , the interaction of @entity7 and the adaptor protein @entity10 was reduced through inhibition of CaMK II by @entity9 . In conclusion, this study reveals that @entity9 can reduce @entity0 via inhibiting the activity of CaMK II, and then increase the level of phosphorylated @entity7 , to reduce the interaction with @entity10 .

title: Phosphorylated neuronal XXXX synthase in @entity0 in @entity2 .

answer: @entity5


abstract: @entity0 caused by nervous system @entity3 . The pathogenesis and the mechanism underlying @entity0 remains unclear. The only known neurobiological component involved in the @entity0 is @entity5 (NO). NO is synthesized by @entity5 synthase ( @entity7 ) from @entity8 and @entity1 . @entity7 is involved in the @entity4 and @entity0 . In this study, we aimed to identify whether @entity9 reduced the @entity4 in the @entity2 . Sixty adult male SD @entity2 were randomly divided into 4 groups. Sham group and model group were not received treatment. Experimental group received intrathecal injection of @entity9 , and negative control group received @entity6 injection 30 min before @entity4 test. After last test of @entity4 threshold, the @entity2 were sacrificed and lumbar spinal tissues were sampled for analysis of the expression of pnNOS and pCaMK II by quantitative PCR and Western blotting. @entity4 threshold was increased in the @entity2 received @entity9 treatment (P<0.01), and the expression levels of pnNOS was increased (P<0.05) in experimental group and accompanied with decrease of CaMK II expression (P<0.05). By administration of @entity9 , the interaction of @entity7 and the adaptor protein @entity10 was reduced through inhibition of CaMK II by @entity9 . In conclusion, this study reveals that @entity9 can reduce @entity0 via inhibiting the activity of CaMK II, and then increase the level of phosphorylated @entity7 , to reduce the interaction with @entity10 .

title: Phosphorylated neuronal @entity5 synthase in XXXX in @entity2 .

answer: @entity0


abstract: @entity0 caused by nervous system @entity3 . The pathogenesis and the mechanism underlying @entity0 remains unclear. The only known neurobiological component involved in the @entity0 is @entity5 (NO). NO is synthesized by @entity5 synthase ( @entity7 ) from @entity8 and @entity1 . @entity7 is involved in the @entity4 and @entity0 . In this study, we aimed to identify whether @entity9 reduced the @entity4 in the @entity2 . Sixty adult male SD @entity2 were randomly divided into 4 groups. Sham group and model group were not received treatment. Experimental group received intrathecal injection of @entity9 , and negative control group received @entity6 injection 30 min before @entity4 test. After last test of @entity4 threshold, the @entity2 were sacrificed and lumbar spinal tissues were sampled for analysis of the expression of pnNOS and pCaMK II by quantitative PCR and Western blotting. @entity4 threshold was increased in the @entity2 received @entity9 treatment (P<0.01), and the expression levels of pnNOS was increased (P<0.05) in experimental group and accompanied with decrease of CaMK II expression (P<0.05). By administration of @entity9 , the interaction of @entity7 and the adaptor protein @entity10 was reduced through inhibition of CaMK II by @entity9 . In conclusion, this study reveals that @entity9 can reduce @entity0 via inhibiting the activity of CaMK II, and then increase the level of phosphorylated @entity7 , to reduce the interaction with @entity10 .

title: Phosphorylated neuronal @entity5 synthase in @entity0 in XXXX .

answer: @entity2


abstract: The effects of @entity5 , a vasodilator, on blood pressure and heart rate, were tested in 13 ambulant @entity0 with mild to severe @entity2 . The @entity0 received @entity5 in total oral doses ranging from 1.5 to 4 mg/kg over a 3-5 day period. Standard laboratory tests were done 24 h before and after the study. Standing and supine blood pressure and heart rate were determined before, and every hour for 6-8 h after drug administration. ECGs were recorded before, during and at the end of each study day. @entity5 reduced the pretreatment standing and supine-blood pressure from 213 +/- 34/126 +/- 21 mmHg and 218 +/- 31/130 +/- 20 mmHg to 156 +/- 33/85 +/- 9 mmHg and 158 +/- 25/88 +/- 11 mmHg at the end of Day 5. Heart rate was only transiently increased in @entity0 with pretreatment values of less than 90 beats/min. Although abnormal ECGs tended towards normalization, there were 2 cases of T-wave inversion (the @entity0 remained asymptomatic). Raised BUN levels tended to decrease towards normal. Side effects reported spontaneously by @entity0 ( @entity1 , palpitations, @entity4 , @entity3 and one case of water retention) appeared to be transient in nature. @entity5 appeared to be a very potent and long lasting antihypertensive agent, whose inherent side effects were only transient in nature.

title: Antihypertensive effects of a novel peripheral vasodilator, XXXX .

answer: @entity5


abstract: UNASSIGNED: @entity1 increase the risk of posttraumatic @entity3 and thus the risk of @entity2 ( @entity2 ). We previously presented the ten-year results of @entity2 performed for posttraumatic @entity3 after an @entity1 ; we now present the twenty-year outcomes. The original publication included sixty-six @entity0 who underwent @entity2 between 1970 and 1993 for posttraumatic @entity3 after open reduction and internal fixation (ORIF) of an @entity1 . Clinical outcomes, implant survivorship, radiographic results, and complications were evaluated. A total of thirty-six @entity0 had died. The mean Harris hip score was 80 at the latest follow-up. Nineteen acetabular and/or femoral components had been revised: eleven for @entity4 , seven for @entity5 , and one for instability. Twenty-year survivorship of the acetabular component was 71% free from revision for @entity4 and 57% free from revision for any reason. @entity2 after ORIF of an @entity1 was associated with fair implant survivorship at twenty years after surgery. It is possible that newer implants with improved fixation surfaces and bearing materials may enhance long-term results, as the most common reasons for failure at twenty years were @entity4 and @entity5 . LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

title: Total Hip Arthroplasty After Operatively Treated XXXX : A Concise Follow-up, at a Mean of Twenty Years, of a Previous Report.

answer: @entity1


abstract: BACKGROUND AND AIMS: Middle ear surgery requires bloodless surgical field for better operating conditions, deep level of anaesthesia and rapid emergence. Recent studies suggest that a2 agonists could provide desired surgical field, sedation and @entity2 . The present study was aimed to evaluate the clinical effects of @entity4 infusion as anaesthetic adjuvant during middle ear surgery using operating microscope. METHODS: Sixty four adult @entity0 aged 18-58 years, American Society of Anaesthesiologists Grades I and II, of both gender were randomised into two comparable equal groups of 32 @entity0 each for middle ear surgery under general anaesthesia with standard anaesthetic technique. After induction of general anaesthesia, @entity0 of Group I were given @entity4 infusion of 0.5  g/kg/h and @entity0 of Group II were given placebo infusion of normal saline. @entity3 concentration was titrated to achieve a systolic blood pressure 30% below the baseline value. All @entity0 were assessed intra-operatively for @entity1 at surgical field, haemodynamic changes, awakening time and post-operative recovery. RESULTS: Statistically significant reduction was observed in the required percentage of @entity3 (0.8    0.6%) to maintain the systolic blood pressure 30% below the baseline values in @entity0 receiving @entity4 infusion when compared to those receiving placebo infusion (1.6    0.7%). @entity0 receiving @entity4 infusion had statistically significant lesser @entity1 at surgical field (P < 0.05). The mean awakening time and recovery from anaesthesia did not show any significant difference between the groups. CONCLUSION: @entity4 infusion can be safely used to provide oligaemic surgical field for better visualization using operating microscope for middle ear surgery.

title: XXXX infusion during middle ear surgery under general anaesthesia to provide oligaemic surgical field: A prospective study.

answer: @entity4


abstract: Invasive @entity13 in @entity0 with @entity12 mostly occurs in the lungs. Invasive @entity13 of other anatomical sites is relatively infrequent and its pathogenesis has not so far been well elucidated. Here, we describe an autopsy case of @entity1 complicated by @entity7 with @entity8 . A 77-year-old Japanese @entity0 with relapsed @entity16 complained of left visual disturbance and weakness of the lower limbs. The diagnosis of @entity15 to the central nervous system was made. Repeated intrathecal injection of @entity11 plus @entity14 resulted in partial amelioration of the @entity2 . However, the @entity0 then developed @entity5 , @entity10 , and subsequent @entity9 . A computed tomography (CT) scan showed a consolidative shadow with halo sign in the left lung field, which was compatible with either invasive @entity3 or @entity13 . These findings accounted for @entity5 and @entity10 , but not @entity9 . Despite antifungal therapy, the @entity0 succumbed to @entity4 after two weeks. Autopsy revealed @entity1 with a fungal ball in the lumina of the adjacent ascending aorta. Intriguingly, autopsy and postmortem CT scan identified left @entity6 due to @entity13 , which accounted for the @entity9 . It is likely that the fungal ball caused the @entity7 through @entity17 . We should suspect @entity17 when we see a @entity0 with @entity1 developing @entity2 .

title: XXXX through @entity17 of pulmonary mucormycosis complicating relapsed leukemia.

answer: @entity7


abstract: Invasive @entity13 in @entity0 with @entity12 mostly occurs in the lungs. Invasive @entity13 of other anatomical sites is relatively infrequent and its pathogenesis has not so far been well elucidated. Here, we describe an autopsy case of @entity1 complicated by @entity7 with @entity8 . A 77-year-old Japanese @entity0 with relapsed @entity16 complained of left visual disturbance and weakness of the lower limbs. The diagnosis of @entity15 to the central nervous system was made. Repeated intrathecal injection of @entity11 plus @entity14 resulted in partial amelioration of the @entity2 . However, the @entity0 then developed @entity5 , @entity10 , and subsequent @entity9 . A computed tomography (CT) scan showed a consolidative shadow with halo sign in the left lung field, which was compatible with either invasive @entity3 or @entity13 . These findings accounted for @entity5 and @entity10 , but not @entity9 . Despite antifungal therapy, the @entity0 succumbed to @entity4 after two weeks. Autopsy revealed @entity1 with a fungal ball in the lumina of the adjacent ascending aorta. Intriguingly, autopsy and postmortem CT scan identified left @entity6 due to @entity13 , which accounted for the @entity9 . It is likely that the fungal ball caused the @entity7 through @entity17 . We should suspect @entity17 when we see a @entity0 with @entity1 developing @entity2 .

title: @entity7 through XXXX of pulmonary mucormycosis complicating relapsed leukemia.

answer: @entity17


abstract: @entity5 is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that @entity1 could increase the risk of @entity5 , and insulin resistance, or @entity3 are an important risk factor for @entity1 @entity5 . Some studies identified that upstream of the transcription start site within the @entity4 gene promoter region-308 polymorphism was associated insulin resistance or @entity3 , while this site was closely related to @entity5 . But no research was performed to evaluate the influence of @entity4 @entity7 polymorphism on @entity3 in @entity6 @entity0 . Here, we recruited 248 @entity6 @entity0 , who were separated into @entity5 with Mets/ @entity5 without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of @entity4 @entity7 polymorphism on @entity3 in @entity6 @entity0 . Single nucleotide polymorphism of @entity4 -308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of @entity8 did not show significant difference between @entity6 @entity0 and normal controls. However, the frequency of A allele was signi   cantly higher in @entity5 group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of @entity0 and genotype of @entity4 @entity7 , we found levels of LDL @entity2 , @entity4 and insulin, and HOMA-IR were significantly higher in the @entity6 @entity0 carrying the GA and AA genotypes than in the carriers of GG genotype of @entity8 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that @entity4 @entity7 variation was related to metabolic phenotype in @entity5 @entity0 . Furthermore, we first identified @entity4 -308 A allele was the risk factor for @entity6 @entity0 with Mets in Hebei population, China.

title: Genetic polymorphisms of the @entity4 @entity7 are associated with XXXX in @entity6 @entity0 from Hebei province, China.

answer: @entity3


abstract: @entity5 is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that @entity1 could increase the risk of @entity5 , and insulin resistance, or @entity3 are an important risk factor for @entity1 @entity5 . Some studies identified that upstream of the transcription start site within the @entity4 gene promoter region-308 polymorphism was associated insulin resistance or @entity3 , while this site was closely related to @entity5 . But no research was performed to evaluate the influence of @entity4 @entity7 polymorphism on @entity3 in @entity6 @entity0 . Here, we recruited 248 @entity6 @entity0 , who were separated into @entity5 with Mets/ @entity5 without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of @entity4 @entity7 polymorphism on @entity3 in @entity6 @entity0 . Single nucleotide polymorphism of @entity4 -308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of @entity8 did not show significant difference between @entity6 @entity0 and normal controls. However, the frequency of A allele was signi   cantly higher in @entity5 group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of @entity0 and genotype of @entity4 @entity7 , we found levels of LDL @entity2 , @entity4 and insulin, and HOMA-IR were significantly higher in the @entity6 @entity0 carrying the GA and AA genotypes than in the carriers of GG genotype of @entity8 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that @entity4 @entity7 variation was related to metabolic phenotype in @entity5 @entity0 . Furthermore, we first identified @entity4 -308 A allele was the risk factor for @entity6 @entity0 with Mets in Hebei population, China.

title: Genetic polymorphisms of the @entity4 XXXX are associated with @entity3 in @entity6 @entity0 from Hebei province, China.

answer: @entity7


abstract: @entity5 is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that @entity1 could increase the risk of @entity5 , and insulin resistance, or @entity3 are an important risk factor for @entity1 @entity5 . Some studies identified that upstream of the transcription start site within the @entity4 gene promoter region-308 polymorphism was associated insulin resistance or @entity3 , while this site was closely related to @entity5 . But no research was performed to evaluate the influence of @entity4 @entity7 polymorphism on @entity3 in @entity6 @entity0 . Here, we recruited 248 @entity6 @entity0 , who were separated into @entity5 with Mets/ @entity5 without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of @entity4 @entity7 polymorphism on @entity3 in @entity6 @entity0 . Single nucleotide polymorphism of @entity4 -308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of @entity8 did not show significant difference between @entity6 @entity0 and normal controls. However, the frequency of A allele was signi   cantly higher in @entity5 group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of @entity0 and genotype of @entity4 @entity7 , we found levels of LDL @entity2 , @entity4 and insulin, and HOMA-IR were significantly higher in the @entity6 @entity0 carrying the GA and AA genotypes than in the carriers of GG genotype of @entity8 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that @entity4 @entity7 variation was related to metabolic phenotype in @entity5 @entity0 . Furthermore, we first identified @entity4 -308 A allele was the risk factor for @entity6 @entity0 with Mets in Hebei population, China.

title: Genetic polymorphisms of the XXXX @entity7 are associated with @entity3 in @entity6 @entity0 from Hebei province, China.

answer: @entity4


abstract: @entity5 is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that @entity1 could increase the risk of @entity5 , and insulin resistance, or @entity3 are an important risk factor for @entity1 @entity5 . Some studies identified that upstream of the transcription start site within the @entity4 gene promoter region-308 polymorphism was associated insulin resistance or @entity3 , while this site was closely related to @entity5 . But no research was performed to evaluate the influence of @entity4 @entity7 polymorphism on @entity3 in @entity6 @entity0 . Here, we recruited 248 @entity6 @entity0 , who were separated into @entity5 with Mets/ @entity5 without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of @entity4 @entity7 polymorphism on @entity3 in @entity6 @entity0 . Single nucleotide polymorphism of @entity4 -308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of @entity8 did not show significant difference between @entity6 @entity0 and normal controls. However, the frequency of A allele was signi   cantly higher in @entity5 group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of @entity0 and genotype of @entity4 @entity7 , we found levels of LDL @entity2 , @entity4 and insulin, and HOMA-IR were significantly higher in the @entity6 @entity0 carrying the GA and AA genotypes than in the carriers of GG genotype of @entity8 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that @entity4 @entity7 variation was related to metabolic phenotype in @entity5 @entity0 . Furthermore, we first identified @entity4 -308 A allele was the risk factor for @entity6 @entity0 with Mets in Hebei population, China.

title: Genetic polymorphisms of the @entity4 @entity7 are associated with @entity3 in XXXX @entity0 from Hebei province, China.

answer: @entity6


abstract: @entity5 is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that @entity1 could increase the risk of @entity5 , and insulin resistance, or @entity3 are an important risk factor for @entity1 @entity5 . Some studies identified that upstream of the transcription start site within the @entity4 gene promoter region-308 polymorphism was associated insulin resistance or @entity3 , while this site was closely related to @entity5 . But no research was performed to evaluate the influence of @entity4 @entity7 polymorphism on @entity3 in @entity6 @entity0 . Here, we recruited 248 @entity6 @entity0 , who were separated into @entity5 with Mets/ @entity5 without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of @entity4 @entity7 polymorphism on @entity3 in @entity6 @entity0 . Single nucleotide polymorphism of @entity4 -308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of @entity8 did not show significant difference between @entity6 @entity0 and normal controls. However, the frequency of A allele was signi   cantly higher in @entity5 group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of @entity0 and genotype of @entity4 @entity7 , we found levels of LDL @entity2 , @entity4 and insulin, and HOMA-IR were significantly higher in the @entity6 @entity0 carrying the GA and AA genotypes than in the carriers of GG genotype of @entity8 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that @entity4 @entity7 variation was related to metabolic phenotype in @entity5 @entity0 . Furthermore, we first identified @entity4 -308 A allele was the risk factor for @entity6 @entity0 with Mets in Hebei population, China.

title: Genetic polymorphisms of the @entity4 @entity7 are associated with @entity3 in @entity6 XXXX from Hebei province, China.

answer: @entity0


abstract: AIM: To determine whether fluoroscope time is a good predictor of @entity0 radiation exposure during endoscopic retrograde cholangiopancreatography. METHODS: This is a prospective observational study of consecutive @entity0 undergoing endoscopic retrograde cholangiopancreatography in a tertiary care setting. Data related to radiation exposure were collected. The following measures were obtained: @entity1 ( @entity1 ), dose area product (DAP) and dose at reference point (DOSERP). Coefficients of determination were calculated to analyze the correlation between @entity1 , DAP and DOSRP. Agreement between @entity1 and DAP/DOSRP was assessed using Bland Altman plots. RESULTS: Four hundred sixty-three data sets were obtained. @entity1 average was 7.3 min. Fluoroscopy related radiation accounted for 86% of the total DAP while acquisition films related radiation accounted for 14% of the DAP. For any given @entity1 there are wide ranges of DAP and DOSERP and the variability in both increases as fluoroscopy time increases. The coefficient of determination (R(2)) on the non transformed data for DAP and DOSERP versus @entity1 were respectively 0.416 and 0.554. While fluoroscopy use was the largest contributor to @entity0 radiation exposure during endoscopic retrograde cholangiography (ERCP), there is a wide variability in DAP and DOSERP that is not accounted for by @entity1 . DAP and DOSERP increase in variability as @entity1 increases. This translates into poor accuracy of @entity1 in predicting DAP and DOSERP at higher radiation doses. CONCLUSION: DAP and DOSERP in addition to @entity1 should be adopted as new ERCP quality measures to estimate @entity0 radiation exposure.

title: Measures of XXXX radiation exposure during endoscopic retrograde cholangiography: beyond fluoroscopy time.

answer: @entity0


abstract: The lethal effects of combinations of @entity1 (ADR) and either @entity3 (HU) or @entity5 ( @entity4 ) were studied in relation to drug-scheduling interval in @entity0 cells grown in vitro. @entity2 was determined by cell cloning in soft agar. Serial kinetic changes induced by a priming dose of HU or @entity4 were monitored by flow cytometry and related to schedule-dependent cell killing by ADR. All drug exposures were for 1 hr. When ADR was given together with either HU or @entity4 , cell log kill was additive. However, when ADR was given after exposure to either HU or @entity4 , cell killing was increased up to 200- to 500-fold, respectively. Maximum schedule-dependent synergism was observed at a drug-scheduling interval of 2 hr; schedule-dependent synergism decreased as the interval between drugs was increased beyond 2 hr. Schedule-dependent synergism was not observed when the same drug combinations were given in reversed order. Drug-induced changes in the DNA histogram were not seen until 5 hr after HU exposure and 8 hr after @entity4 exposure. Thus, the schedule-dependent synergism between ADR and either HU or @entity4 cannot be explained by cell cycle blockade with synchronization of cells in S phase.

title: Schedule-dependent synergism of combinations of XXXX with @entity1 and @entity5 with @entity1 .

answer: @entity3