abstract: UNASSIGNED: Aims and background. To evaluate results of an intensity-modulated radiotherapy with simultaneous integrated boost schedule with concurrent and neo-adjuvant @entity5 -based chemotherapy for the definitive treatment of locally advanced @entity3 in a retrospective series. Methods and study design. Between May 2007 and February 2010, 28 consecutive @entity0 with locally advanced @entity3 (stage II, 11%; III, 18%; IV, 71%) received intensity-modulated radiotherapy with simultaneous integrated boost with concurrent and neoadjuvant (20/28 @entity0 ) chemotherapy, at 1.8 G/die to 54 Gy to the elective volume and 66 Gy (2.2 Gy/die) to the @entity1 volume. @entity4 were scored according to RTOG/EORTC. A quality of life questionnaire for late @entity7 was also administered. Locoregional control and overall survival were estimated using Kaplan-Meier analysis. Results. Median follow-up was 50 months, there was no grade 4 acute/late @entity4 . Major acute @entity4 were grade 2+ @entity2 , 79%; grade 2+ @entity7 , 54%; grade 2+ @entity6 , 86%; 54% of @entity0 required parenteral nutrition. The most relevant late reaction was grade 1 @entity7 (64%), which gradually recovered with time. A linear correlation between the RTOG/EORTC scale and the quality of life questionnaire value (P = 0.0120, r2 = 0.2641) was found, receiver operating characteristic analysis (ROC) confirmed sensitivity of the quality of life questionnaire to define grade 2 late salivary @entity4 (P = 0.019). Five-year actuarial locoregional control and overall survival were 81%    7.7 SE and 82%    7.3 SE, respectively. Conclusions. A prospective trial of the intensity-modulated radiotherapy with simultaneous integrated boost schedule tested in this retrospective series with concurrent and neoadjuvant chemotherapy seems warranted in order to establish this approach as a standard regimen of intensity-modulated radiotherapy with simultaneous integrated boost chemoradiation.

title: IMRT-SIB with concurrent and neo-adjuvant XXXX -based chemotherapy for locally advanced head and neck squamous cell cancer: analysis of clinical outcomes in a retrospective series of a single institution.

answer: @entity5


abstract: UNASSIGNED: @entity4 ( @entity4 ) is characterized by an abundant @entity8 . We examined the prognostic value of stroma density and activity in @entity0 with resectable @entity4 treated with surgery and adjuvant @entity3 -based chemotherapy. FFPE-tissue from the pancreatectomy of 145 @entity0 was immunohistochemically stained for @entity9 - @entity6 and Masson's trichrome to assess stroma density, and @entity7 ( @entity7 ) expression for activated pancreatic stellate cells. Their expression was correlated with clinicopathological characteristics as well as @entity5 ( @entity5 ), progression-free survival (PFS), local progression-free survival (LPFS) and distant @entity1 free-survival (DMFS). After a mean follow-up of 20 months (range, 2-69 months), the median @entity5 was 21 months and the 3-year @entity5 was 35.7%. In multivariate analysis, highly-dense stroma was an independent prognostic parameter for @entity5 (p = 0.001), PFS (p = 0.007), LPFS (p = 0.001) and DMFS (p = 0.002), while @entity7 expression lacked significance. Interestingly, highly-dense stroma retained significance for the four clinical endpoints only in early (pT1-2) but not late (pT3-4) stage @entity2 . Additionally, late pT-stage (pT3-4), the presence of lymph node @entity1 (pN+ vs pN0), perineural/neural invasion and administration of adjuvant chemotherapy also correlated with prognosis in multivariate analysis. Altogether, stroma density constitutes an independent prognostic marker in @entity4 @entity0 treated with adjuvant chemotherapy. Our findings highlight the dynamic complexity of desmoplasia and indicate that highly-dense stroma is correlated with better outcome. Further validation of the prognostic value of stroma as a biomarker and its role in @entity4 @entity0 after adjuvant chemotherapy is warranted and will be performed in a prospective study.

title: The prognostic role of @entity8 in XXXX .

answer: @entity4


abstract: UNASSIGNED: @entity4 ( @entity4 ) is characterized by an abundant @entity8 . We examined the prognostic value of stroma density and activity in @entity0 with resectable @entity4 treated with surgery and adjuvant @entity3 -based chemotherapy. FFPE-tissue from the pancreatectomy of 145 @entity0 was immunohistochemically stained for @entity9 - @entity6 and Masson's trichrome to assess stroma density, and @entity7 ( @entity7 ) expression for activated pancreatic stellate cells. Their expression was correlated with clinicopathological characteristics as well as @entity5 ( @entity5 ), progression-free survival (PFS), local progression-free survival (LPFS) and distant @entity1 free-survival (DMFS). After a mean follow-up of 20 months (range, 2-69 months), the median @entity5 was 21 months and the 3-year @entity5 was 35.7%. In multivariate analysis, highly-dense stroma was an independent prognostic parameter for @entity5 (p = 0.001), PFS (p = 0.007), LPFS (p = 0.001) and DMFS (p = 0.002), while @entity7 expression lacked significance. Interestingly, highly-dense stroma retained significance for the four clinical endpoints only in early (pT1-2) but not late (pT3-4) stage @entity2 . Additionally, late pT-stage (pT3-4), the presence of lymph node @entity1 (pN+ vs pN0), perineural/neural invasion and administration of adjuvant chemotherapy also correlated with prognosis in multivariate analysis. Altogether, stroma density constitutes an independent prognostic marker in @entity4 @entity0 treated with adjuvant chemotherapy. Our findings highlight the dynamic complexity of desmoplasia and indicate that highly-dense stroma is correlated with better outcome. Further validation of the prognostic value of stroma as a biomarker and its role in @entity4 @entity0 after adjuvant chemotherapy is warranted and will be performed in a prospective study.

title: The prognostic role of XXXX in @entity4 .

answer: @entity8


abstract: BACKGROUND/OBJECT: The recent trend for treatment of certain cases of @entity1 has been towards motion preserving surgery. This is claimed to be achieved with placement of pedicle screws across the @entity1 fragments. However, the long term outcome in clinical scenario is not yet clear, neither are the factors determining suitability of such a technique. MATERIALS AND METHODS: We have retrospectively analyzed the results of 11 @entity0 of @entity1 , according to the extent of translation. Nine @entity0 underwent stabilization of @entity1 with C2 pedicle screws and 2 were managed with halo immobilization. The conservative management failed in one and this @entity0 underwent internal fixation using pars-pedicle screw as well. The long term clinical and radiological (CT and dynamic X-rays) outcome was analyzed. RESULTS: All @entity0 including the one with halo immobilization, showed solid fusion across the @entity1 fragments. With the exception of one @entity0 none had any clinical symptoms. This lone @entity0 complained of @entity2 . Three different types of radiological results were observed. Two @entity0 with translation >8mm showed @entity3 body fusion. Three of 6 @entity0 with minimal translational (3-4mm) showed facet fusion. Three @entity0 with moderate translational dislocation (4.5-5.5mm) showed persisting @entity3 angular instability. CONCLUSIONS: The C2 pedicle screw is a good technique for osteosynthesis. However, the claimed long term advantage of motion segment preservation with this technique remains doubtful. It may be suitable for those @entity1 with minimal translation (<4mm), where the superiority of surgery, itself, over external immobilization is questionable. @entity3 fusion is preferable for those @entity1 with translation >4mm as these are unstable and C2 pedicle screws alone are likely to have less desirable results.

title: Are C2 pars-pedicle screws alone for XXXX overrated?

answer: @entity1


abstract: OBJECTIVE: Management of extremely large birthweight @entity0 presents challenges during the period of labour and delivery. We sought to examine outcomes in @entity0 with extreme @entity5 (birthweight  >  5000  g), at an institution where the management of labour is standardised. MATERIALS AND METHODS: This is a retrospective analysis of prospectively gathered data on all @entity0 with a birthweight >5000  g delivered at a tertiary level institution from 2008 to 2012. Details of labour characteristics and outcomes were examined; these were compared according to parity. RESULTS: During the study period, there were 46  128 deliveries at the hospital and 182 @entity0 with a birthweight >5000  g, giving an incidence of 0.4%. The majority of @entity0 (133/182) were multiparous. Among nulliparas, 47% (23/49) had a vaginal delivery, while 53% (26/49) had a caesarean delivery. 86% (97/113) of multiparas had a vaginal delivery, and 14% (16/113) had a caesarean delivery. 43% (69/162) required induction of labour. This was more common in nulliparous compared with multiparous @entity0 (58% [29/49] vs 30% [40/133], P  =  0.005, OR  =  3.4, 95% CI  =  1.7-6.6). A total of 30% (49/162) of @entity0 had their labour accelerated with @entity2 . There were higher rates of @entity2 use in nulliparas than in multiparas (55% [27/49] vs 16.5% [22/133], P  <  0.0001, OR  =  6.2, 95% CI  =  3-12.8). Seventeen of the 120 @entity0 delivered vaginally had a shoulder @entity3 (14.2%), with three suffering an @entity4 , all of which had resolved before 6  months of age. One baby had a @entity1 . CONCLUSION: Extreme @entity5 affects 0.4% of pregnancies in contemporary practice. Multiparas have a low rate of caesarean section. @entity0 delivered vaginally are at increased risk of shoulder @entity3 and associated complications.

title: Extreme XXXX - Obstetric outcomes and complications in birthweights >5000  g.

answer: @entity5


abstract: An inexpensive, rapid, and simple colorimetric test for detection of @entity1 is described. This test does not require bacterial growth and has the marked advantage of being able to quantify bacteria, even when the organisms are present in the urine of bacteriuric @entity0 who are being treated with antibiotics. The test is carried out with 1 ml of urine, which is processed through a 10-mm-diameter filter than entraps the bacteria on its surface. @entity2 dye is passed through the filter to stain the bacteria and the filter fibers. A decolorizer, which removes the dye from the filter fibers but not from the bacteria, is then passed through the filter. If there are greater than or equal to 10(5) colony-forming units of bacteria per ml in the sample, the 10-mm filter disk manifests a pink to red color. If there are less than 10(5)colony-forming units of bacteria per ml, the filter disk remains white or becomes slightly yellow. The entire procedure has been adapted to a semiautomated instrument and the time required per test is less than 1 min. The results obtained on the test card are a permanent record to be filled with the @entity0 's chart. The bacteria can be quickly classified as gram positive or gram negative by selective staining of a second milliliter of urine on the filter. Of 441 urine specimens tested, 430 (98%) were correctly classified as containing more or less than 10(5) colony-forming units per ml. A total of 62 urine specimens were positive by bacterial plating (greater than or equal to 10(5) colony-forming units per ml), and 59 were positive by the colorimetric test. Eight false-positives (colorimetric test positive, plate counts less than 10(5)) were encountered in @entity0 (bacteriuric) being prescribed antibiotics. Removal of the antibiotics from these urine specimens, with subsequent replating of the samples, indicated the presence of greater than or equal to 10(5) colony-forming units of bacteria per ml in three representative cases tested, indicating that the results of the colorimetric tests were not false-positives but that the plate counts were low because of the inhibition of bacterial growth by the residual antibiotics present in the urine.

title: Colorimetric method for rapid determination of XXXX .

answer: @entity1


abstract: BACKGROUND: This randomized, open-label, multicenter, phase II clinical trial was conducted to assess the anti- @entity1 efficacy and safety of replication-deficient adenovirus mutant @entity4 kinase (ADV-TK) in combination with @entity6 administration in @entity0 with recurrent high-grade @entity2 (HGG). @entity0 AND METHODS: 53 @entity0 with recurrent HGG were randomly allocated to receive intra-arterial cerebral infusion of ADV-TK or conventional treatments. The primary end point was 6-month progression-free survival (PFS-6). Secondary end points included progression-free survival (PFS), @entity5 ( @entity5 ), safety, and clinical benefit. This trial is registered with Clinicaltrials.gov, NCT00870181. RESULTS: In ADV-TK group, PFS-6 was 54.5%, the median PFS was 29.6 weeks, the median @entity5 was 45.4 weeks, and better survivals were achieved when compared with control group. The one-year PFS and @entity5 were 22.7% and 44.6% in ADV-TK group respectively, and clinical benefit was 68.2%. There are 2 @entity0 alive for more than 4 years without progression in ADV-TK group. In the subgroup of @entity3 received ADV-TK, PFS-6 was 71.4%, median PFS was 34.9 weeks, median @entity5 was 45.7 weeks respectively, much better than those in control group. The one-year PFS and @entity5 were 35.7% and 50.0% in ADV-TK group respectively. ADV-TK/ @entity6 gene therapy was well tolerated, and no treatment-related severe adverse events were noted. CONCLUSION: Our study demonstrated a notable improvement of PFS-6, PFS and @entity5 in ADV-TK treated group, and the efficacy and safety appear to be comparable to other reported treatments used for recurrent HGG. ADV-TK gene therapy is therefore a valuable therapeutic option for recurrent HGG.

title: Adenovirus-mediated delivery of herpes simplex virus XXXX kinase administration improves outcome of recurrent high-grade @entity2 .

answer: @entity4


abstract: BACKGROUND: This randomized, open-label, multicenter, phase II clinical trial was conducted to assess the anti- @entity1 efficacy and safety of replication-deficient adenovirus mutant @entity4 kinase (ADV-TK) in combination with @entity6 administration in @entity0 with recurrent high-grade @entity2 (HGG). @entity0 AND METHODS: 53 @entity0 with recurrent HGG were randomly allocated to receive intra-arterial cerebral infusion of ADV-TK or conventional treatments. The primary end point was 6-month progression-free survival (PFS-6). Secondary end points included progression-free survival (PFS), @entity5 ( @entity5 ), safety, and clinical benefit. This trial is registered with Clinicaltrials.gov, NCT00870181. RESULTS: In ADV-TK group, PFS-6 was 54.5%, the median PFS was 29.6 weeks, the median @entity5 was 45.4 weeks, and better survivals were achieved when compared with control group. The one-year PFS and @entity5 were 22.7% and 44.6% in ADV-TK group respectively, and clinical benefit was 68.2%. There are 2 @entity0 alive for more than 4 years without progression in ADV-TK group. In the subgroup of @entity3 received ADV-TK, PFS-6 was 71.4%, median PFS was 34.9 weeks, median @entity5 was 45.7 weeks respectively, much better than those in control group. The one-year PFS and @entity5 were 35.7% and 50.0% in ADV-TK group respectively. ADV-TK/ @entity6 gene therapy was well tolerated, and no treatment-related severe adverse events were noted. CONCLUSION: Our study demonstrated a notable improvement of PFS-6, PFS and @entity5 in ADV-TK treated group, and the efficacy and safety appear to be comparable to other reported treatments used for recurrent HGG. ADV-TK gene therapy is therefore a valuable therapeutic option for recurrent HGG.

title: Adenovirus-mediated delivery of herpes simplex virus @entity4 kinase administration improves outcome of recurrent high-grade XXXX .

answer: @entity2


abstract: BACKGROUND: Disruption of anterior cruciate ligament (ACL) is a common ligamentous injury of the knee. The choice of graft for (ACL) reconstruction remains controversial. This prospective, randomized clinical trial aimed to compare clinical results of @entity1 ( @entity1 ) grafts and four-strand semitendinosus-gracilis (ST) grafts for ACL reconstruction over a 3-year follow-up interval. METHODS: Seventy-one @entity0 with an average age of 29   4.5yearswere treated for torn ACL between 2008 and 2009. Forty-sixpatients underwent reconstruction with @entity1 autograft, and 41 were treated with ST autograft. At the time of final follow-up, 37 @entity0 in @entity3 group and 34 @entity0 in hamstring group were evaluated in terms of return to pre-injury activity level, @entity2 , knee stability, range of motion, IKDC (International Knee Documentation Committee) score and complications. RESULTS: At 36thmonth of follow-up, 34 (92%) and 28 (82%) @entity0 in @entity1 and ST group, respectively had good-to-excellent IKDC score (p > 0.05). The activity levels were higher in @entity1 group (p> 0.05). At 3rd yearof follow up, the Lachman test was graded normal, for 23 (62%) and 11 (32%) @entity0 in @entity1 and ST group, respectively (p=0.019). Regarding the pivot-shift test, 29 (79%) and 15 (44%) @entity0 in @entity3 and hamstring group, respectively had normal test at the latest follow-up (p=0.021).There were no significant differences in terms of thigh circumference difference, effusion, knee range of motion, @entity2 and complications. CONCLUSION: The results indicate a trend toward increased graft laxity and pivot-shift grades in @entity0 undergoing reconstruction with hamstring autograft compared with @entity3 tendon. However, the two groups had comparable results in terms of activity level and knee function.

title: Reconstruction of the anterior cruciate ligament: a comparison between XXXX grafts and fourstrand hamstring grafts.

answer: @entity1


abstract: BACKGROUND: @entity1 are common among @entity0 with @entity3 ( @entity3 ), and it can have a significant effect on @entity0 ' daily activities as well as their health. The purpose of this study was to assess @entity1 and its predictors in Iranian @entity0 with chronic @entity3 . METHODS: This cross-sectional study was conducted on a sample of 200 @entity0 with @entity3 in two hospitals of Tehran University of Medical Sciences from June to November 2009. These @entity0 completed a demographic questionnaire, and their @entity1 was measured using the Pittsburgh Sleep Quality Index (PSQI). One-way analysis of variance (ANOVA), Kruskal-Wallis test, t-test and Linear regression were used for data analysis. RESULTS: Seventy-nine percent of @entity0 (n = 158) reported poor @entity1 (PSQI > 5). The range of global PSQI scores was 3-20. Also, a significant relationship was found between PSQI scores and @entity0 ' age (p<0.004), gender (p< 0.042), educational level (p< 0.001), occupational status (p< 0.038), number of hospitalizations (p< 0.005), type of referral (p< 0.001), @entity2 (p< 0.001), diuretic use (p< 0.021) and left ventricular ejection fraction (p< 0.015). Three predictors were identified using regression analyses with stepwise methods, and included age, type of referral and educational level. CONCLUSION: The high prevalence of poor @entity1 highlighted the importance of @entity1 in @entity3 @entity0 . There are many factors associated with @entity1 and @entity1 that health providers should recognize for improved and effective management.

title: Sleep quality and associated factors among @entity0 with XXXX in Iran.

answer: @entity3


abstract: BACKGROUND: @entity1 are common among @entity0 with @entity3 ( @entity3 ), and it can have a significant effect on @entity0 ' daily activities as well as their health. The purpose of this study was to assess @entity1 and its predictors in Iranian @entity0 with chronic @entity3 . METHODS: This cross-sectional study was conducted on a sample of 200 @entity0 with @entity3 in two hospitals of Tehran University of Medical Sciences from June to November 2009. These @entity0 completed a demographic questionnaire, and their @entity1 was measured using the Pittsburgh Sleep Quality Index (PSQI). One-way analysis of variance (ANOVA), Kruskal-Wallis test, t-test and Linear regression were used for data analysis. RESULTS: Seventy-nine percent of @entity0 (n = 158) reported poor @entity1 (PSQI > 5). The range of global PSQI scores was 3-20. Also, a significant relationship was found between PSQI scores and @entity0 ' age (p<0.004), gender (p< 0.042), educational level (p< 0.001), occupational status (p< 0.038), number of hospitalizations (p< 0.005), type of referral (p< 0.001), @entity2 (p< 0.001), diuretic use (p< 0.021) and left ventricular ejection fraction (p< 0.015). Three predictors were identified using regression analyses with stepwise methods, and included age, type of referral and educational level. CONCLUSION: The high prevalence of poor @entity1 highlighted the importance of @entity1 in @entity3 @entity0 . There are many factors associated with @entity1 and @entity1 that health providers should recognize for improved and effective management.

title: Sleep quality and associated factors among XXXX with @entity3 in Iran.

answer: @entity0


abstract: BACKGROUND: Chemicals are among risk factors that can affect @entity0 's reproductive system. This study is aimed to investigate the association of occupational exposure to a mixture of organic solvents with @entity1 and hormonal changes among female workers. METHODS: Female workers of a pharmaceutical company were divided into three groups of non-exposed, lowexposed and highly-exposed to a mixture of organic solvents ( @entity3 , @entity9 , @entity5 , and @entity8 ) based on workplace measurements. @entity7 (in terms of short cycles, long cycles, irregular cycles, and @entity4 or spotting between periods) and mean of hormone levels (including follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, prolactin, @entity2 and @entity6 levels) were compared between these three groups. For investigating associations, logistic regression was performed. RESULTS: Our study showed that mean length of cycles, duration of @entity4 , and amount of flow and also prevalence of long cycles, irregular cycles, and @entity4 or spotting between periods were higher in exposed groups (p <=0.05). Odds ratio for prevalence of @entity7 in the low exposure group and high exposure group were 9.69 (p=0.001) and 3.40 (p=0.002) respectively compared to the reference group. @entity2 and @entity6 levels were not affected (p> 0.05), but other hormones levels were significantly disturbed in the exposed groups compared with the non-exposed group (p=0.001). CONCLUSION: Occupational exposure to the mixture of organic solvents may be associated with the increase of @entity7 and hormonal changes in female workers. Based on our findings, periodic evaluation of reproductive system of female workers in pharmaceutical companies is recommended.

title: XXXX and hormonal changes in @entity0 workers exposed to a mixture of organic solvents in a pharmaceutical company.

answer: @entity7


abstract: BACKGROUND: Chemicals are among risk factors that can affect @entity0 's reproductive system. This study is aimed to investigate the association of occupational exposure to a mixture of organic solvents with @entity1 and hormonal changes among female workers. METHODS: Female workers of a pharmaceutical company were divided into three groups of non-exposed, lowexposed and highly-exposed to a mixture of organic solvents ( @entity3 , @entity9 , @entity5 , and @entity8 ) based on workplace measurements. @entity7 (in terms of short cycles, long cycles, irregular cycles, and @entity4 or spotting between periods) and mean of hormone levels (including follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, prolactin, @entity2 and @entity6 levels) were compared between these three groups. For investigating associations, logistic regression was performed. RESULTS: Our study showed that mean length of cycles, duration of @entity4 , and amount of flow and also prevalence of long cycles, irregular cycles, and @entity4 or spotting between periods were higher in exposed groups (p <=0.05). Odds ratio for prevalence of @entity7 in the low exposure group and high exposure group were 9.69 (p=0.001) and 3.40 (p=0.002) respectively compared to the reference group. @entity2 and @entity6 levels were not affected (p> 0.05), but other hormones levels were significantly disturbed in the exposed groups compared with the non-exposed group (p=0.001). CONCLUSION: Occupational exposure to the mixture of organic solvents may be associated with the increase of @entity7 and hormonal changes in female workers. Based on our findings, periodic evaluation of reproductive system of female workers in pharmaceutical companies is recommended.

title: @entity7 and hormonal changes in XXXX workers exposed to a mixture of organic solvents in a pharmaceutical company.

answer: @entity0


abstract: INTRODUCTION: Percutaneous nephrolithotomy (PCNL) is a standard, safe, and efficient method for removing @entity5 . Despite development of endourologic equipment, complications of the PCNL are still prevalent. Even though therapeutic modalities such as mini-micro PCNL have been developed in recent years, the complications are a serious concern yet. The most important complication is @entity2 . The @entity2 may be either arterial or venous. @entity2 is usually treated conservatively whereas the arterial one might require transarterial embolization (TAE). @entity2 may cause serious problems, especially in the @entity0 with @entity1 . CASE PRESENTATION: In the presented @entity0 , serious retroperitoneal @entity2 and @entity3 in the preoperative and postoperative periods resulted in @entity4 ( @entity4 ). CONCLUSIONS: It was first report of selective TAE in a @entity0 with @entity4 due to post-PCNL @entity6 in @entity1 . Super-selective segmental embolization was performed successfully in this case and was shown to be a reliable and efficient procedure.

title: Intrarenal @entity6 after percutaneous nephrolithotomy at XXXX .

answer: @entity1


abstract: INTRODUCTION: Percutaneous nephrolithotomy (PCNL) is a standard, safe, and efficient method for removing @entity5 . Despite development of endourologic equipment, complications of the PCNL are still prevalent. Even though therapeutic modalities such as mini-micro PCNL have been developed in recent years, the complications are a serious concern yet. The most important complication is @entity2 . The @entity2 may be either arterial or venous. @entity2 is usually treated conservatively whereas the arterial one might require transarterial embolization (TAE). @entity2 may cause serious problems, especially in the @entity0 with @entity1 . CASE PRESENTATION: In the presented @entity0 , serious retroperitoneal @entity2 and @entity3 in the preoperative and postoperative periods resulted in @entity4 ( @entity4 ). CONCLUSIONS: It was first report of selective TAE in a @entity0 with @entity4 due to post-PCNL @entity6 in @entity1 . Super-selective segmental embolization was performed successfully in this case and was shown to be a reliable and efficient procedure.

title: Intrarenal XXXX after percutaneous nephrolithotomy at @entity1 .

answer: @entity6


abstract: The effect of growth temperature on the loss of virulence of the fish pathogen @entity3 was investigated. Three virulent strains were grown in Trypticase soy broth at temperatures ranging from 22 to 30 degrees C. Growth at a higher-than-optimal temperature (26 to 27 degrees C for the three strains studied) resulted in the selection of spontaneous attenuated derivatives in the initial bacterial population. For example, virulent bacteria represented less than 10% of the population of a culture grown at 30 degrees C, and attenuated derivatives were easily isolated by streaking the culture on solid medium and picking single colonies. Virulent strains autoaggregated during growth and possessed a cell wall layer (A-layer) external to the outer membrane, as previously described. @entity1 did not autoaggregate and did not possess the A-layer. The A-layer apparently shielded bacteriophage receptors and a @entity2 -specific @entity0 agglutinin located in the outer membrane. Thus, virulent strains exhibited impaired adsorption of phages, whereas attenuated strains were phage sensitive. Furthermore, attenuated strains agglutinated @entity0 cells but virulent strains did not. The attenuated strains had higher maximum growth temperatures than their virulent parent strains, and this accounts for their selection at high temperatures. It is proposed that the A-layer contributes significantly to the physical properties of the A. salmonicida cell envelope and that these physical properties of the A. salmonicida cell envelope and that these physical change upon loss of the A-layer to permit growth at a higher-than-usual temperature.

title: Loss of virulence during culture of XXXX at high temperature.

answer: @entity3


abstract: UNASSIGNED: @entity3 ( @entity3 ) is rare which can regress spontaneously. Arteriovenous shunts within @entity11 , however, may result in @entity4 ( @entity4 ) and @entity9 ( @entity9 ).The authors report 2 young @entity0 suffering from multifocal @entity3 associated with @entity9 were both treated with glucocorticoid and transcatheter @entity10 (TAE), but had different outcomes. The @entity4 decreased immediately and the symptoms of @entity9 were alleviated after TAE for both of them. For the Tibetan @entity0 , the development was normal with @entity1 regression by follow-up. For the Han ethnic neonate, @entity4 increased again in the seventh day with progressive @entity2 . Ultrasound showed a persisting perfusion caused by collateralization around occluded main feeders. Furthermore, a @entity7 occurred and ventilation was performed. As a result, the @entity0 died from @entity5 caused by @entity9 and @entity6 .TAE is a treatment of reducing shunting for @entity11 . Fistula recanalization in multifocal @entity3 , however, might be an important risk factor affecting the outcome of TAE. TAE should be further evaluated with special attention to anatomy of feeding and draining vessels, and cardiopulmonary conditions. In addition, the @entity0 were susceptible to secondary @entity7 because of @entity7 . As well, the @entity0 from the high altitude area showed better adaptability to @entity8 .

title: Infantile XXXX Associated With @entity9 : Two Case Reports With Different Outcomes.

answer: @entity3


abstract: UNASSIGNED: @entity3 ( @entity3 ) is rare which can regress spontaneously. Arteriovenous shunts within @entity11 , however, may result in @entity4 ( @entity4 ) and @entity9 ( @entity9 ).The authors report 2 young @entity0 suffering from multifocal @entity3 associated with @entity9 were both treated with glucocorticoid and transcatheter @entity10 (TAE), but had different outcomes. The @entity4 decreased immediately and the symptoms of @entity9 were alleviated after TAE for both of them. For the Tibetan @entity0 , the development was normal with @entity1 regression by follow-up. For the Han ethnic neonate, @entity4 increased again in the seventh day with progressive @entity2 . Ultrasound showed a persisting perfusion caused by collateralization around occluded main feeders. Furthermore, a @entity7 occurred and ventilation was performed. As a result, the @entity0 died from @entity5 caused by @entity9 and @entity6 .TAE is a treatment of reducing shunting for @entity11 . Fistula recanalization in multifocal @entity3 , however, might be an important risk factor affecting the outcome of TAE. TAE should be further evaluated with special attention to anatomy of feeding and draining vessels, and cardiopulmonary conditions. In addition, the @entity0 were susceptible to secondary @entity7 because of @entity7 . As well, the @entity0 from the high altitude area showed better adaptability to @entity8 .

title: Infantile @entity3 Associated With XXXX : Two Case Reports With Different Outcomes.

answer: @entity9


abstract: BACKGROUND: There has been an increasing popularity of searching health related information online in recent years. Despite that considerable amount of @entity1 @entity0 have shown interest in obtaining @entity1 information through Internet, previous studies have demonstrated poor quality of online information. However, this conclusion may vary depending on region and culture. Since China has a restricted Internet access outside of its borders, the aim of this study is to evaluate the quality of @entity1 information available online using recognized scoring systems and to analyze the Internet as a source of health information in China. METHODS: A survey-based questionnaire was distributed to 280 respondents at outpatient clinics. Information on demographics and Internet use was collected. Binary logistic analysis was performed to identify possible predictors for the use of Internet. In addition, the top 60 @entity1 related websites assessed through 4 search engines were reviewed by a surgeon and the quality of online information was evaluated using DISCERN score and @entity2 benchmark. RESULTS: Use of the Internet as a source for @entity1 related information was confirmed in 87.8% of the respondents. College education, Internet access at home and urban residence were identified as potential predictors for Internet use. However, the quality of online @entity1 related information was poor with an average DISCERN score of 27.9  11.7 and may be misleading for @entity1 @entity0 . CONCLUSION: The study outlines the profile of @entity1 @entity0 who use the Internet as a source of health information. It was shown that 87.8% of the @entity1 @entity0 in outpatient clinics have searched for @entity1 related information on Internet. Urban @entity0 , higher education and Internet access at home were identified as potential predictors for Internet search. However, the overall quality of online @entity1 related information was poor and confusing. Physician based websites seemed to contain more reliable information.

title: Scoliosis related information on the internet in china: can XXXX benefit from this information?

answer: @entity0


abstract: OBJECTIVE: To analyze @entity2 ( @entity2 ) and clinical parameters around narrow-diameter implants (NDIs - 3.3  mm) made of @entity3 / @entity5 alloy (TiZr) in comparison with commercially pure @entity3 (cpTi) installed in the molar region of the mandible after 1  year in function. MATERIALS AND METHODS: Ten @entity0 participated in the study. A TiZr and a cpTi @entity4 were randomly installed in contralateral molar sites of the mandible of each @entity0 in a split-mouth design. Eight weeks after healing, all metal-ceramic single crowns were adapted to the implants and @entity0 were enrolled in a plaque control program. @entity2 at the mesial and distal aspects of the implants were evaluated by comparing periapical radiographs taken immediately after prosthesis installation (T1) and 1  year after loading (T2). Clinical probing depth, @entity1 on probing, suppuration, visible plaque and implant mobility were evaluated to determine implant success and survival rates. RESULTS: Mean @entity2 at the interproximal aspects of TiZr implant sites was 0.32      0.27  mm, while at cpTi implant sites mean @entity2 was 0.35      0.24  mm (P  =  0.60). Both TiZr and cpTi NDIs presented 100% implant survival and success rates, with no significant differences in the clinical parameters studied (P  >  0.05). CONCLUSION: TiZr and cpTi NDIs presented similar outcomes after 1  year in function in the molar region of the mandible. The results suggest that TiZr and cpTi NDIs may be equally used to support single crowns in the posterior area of the mouth. However, further studies with longer follow-up periods are necessary to confirm these findings.

title: One-year follow-up of XXXX / @entity5 alloy X commercially pure @entity3 narrow-diameter implants placed in the molar region of the mandible: a randomized controlled trial.

answer: @entity3


abstract: OBJECTIVE: To analyze @entity2 ( @entity2 ) and clinical parameters around narrow-diameter implants (NDIs - 3.3  mm) made of @entity3 / @entity5 alloy (TiZr) in comparison with commercially pure @entity3 (cpTi) installed in the molar region of the mandible after 1  year in function. MATERIALS AND METHODS: Ten @entity0 participated in the study. A TiZr and a cpTi @entity4 were randomly installed in contralateral molar sites of the mandible of each @entity0 in a split-mouth design. Eight weeks after healing, all metal-ceramic single crowns were adapted to the implants and @entity0 were enrolled in a plaque control program. @entity2 at the mesial and distal aspects of the implants were evaluated by comparing periapical radiographs taken immediately after prosthesis installation (T1) and 1  year after loading (T2). Clinical probing depth, @entity1 on probing, suppuration, visible plaque and implant mobility were evaluated to determine implant success and survival rates. RESULTS: Mean @entity2 at the interproximal aspects of TiZr implant sites was 0.32      0.27  mm, while at cpTi implant sites mean @entity2 was 0.35      0.24  mm (P  =  0.60). Both TiZr and cpTi NDIs presented 100% implant survival and success rates, with no significant differences in the clinical parameters studied (P  >  0.05). CONCLUSION: TiZr and cpTi NDIs presented similar outcomes after 1  year in function in the molar region of the mandible. The results suggest that TiZr and cpTi NDIs may be equally used to support single crowns in the posterior area of the mouth. However, further studies with longer follow-up periods are necessary to confirm these findings.

title: One-year follow-up of @entity3 / @entity5 alloy X commercially pure XXXX narrow-diameter implants placed in the molar region of the mandible: a randomized controlled trial.

answer: @entity3


abstract: OBJECTIVE: To analyze @entity2 ( @entity2 ) and clinical parameters around narrow-diameter implants (NDIs - 3.3  mm) made of @entity3 / @entity5 alloy (TiZr) in comparison with commercially pure @entity3 (cpTi) installed in the molar region of the mandible after 1  year in function. MATERIALS AND METHODS: Ten @entity0 participated in the study. A TiZr and a cpTi @entity4 were randomly installed in contralateral molar sites of the mandible of each @entity0 in a split-mouth design. Eight weeks after healing, all metal-ceramic single crowns were adapted to the implants and @entity0 were enrolled in a plaque control program. @entity2 at the mesial and distal aspects of the implants were evaluated by comparing periapical radiographs taken immediately after prosthesis installation (T1) and 1  year after loading (T2). Clinical probing depth, @entity1 on probing, suppuration, visible plaque and implant mobility were evaluated to determine implant success and survival rates. RESULTS: Mean @entity2 at the interproximal aspects of TiZr implant sites was 0.32      0.27  mm, while at cpTi implant sites mean @entity2 was 0.35      0.24  mm (P  =  0.60). Both TiZr and cpTi NDIs presented 100% implant survival and success rates, with no significant differences in the clinical parameters studied (P  >  0.05). CONCLUSION: TiZr and cpTi NDIs presented similar outcomes after 1  year in function in the molar region of the mandible. The results suggest that TiZr and cpTi NDIs may be equally used to support single crowns in the posterior area of the mouth. However, further studies with longer follow-up periods are necessary to confirm these findings.

title: One-year follow-up of @entity3 / XXXX alloy X commercially pure @entity3 narrow-diameter implants placed in the molar region of the mandible: a randomized controlled trial.

answer: @entity5


abstract: INTRODUCTION AND AIMS: This study estimates the burden of drug and @entity2 morbidity on hospitals in New South Wales (NSW) by observing a multi-site collective sample utilising survey information and data linkage. Specifically we aimed to determine the prevalence of @entity2 and other drug (AOD) problems and to estimate patterns of utilisation of hospital services, costs of presentations, and admissions for @entity0 with AOD problems. DESIGN AND METHODS: @entity0 were recruited from eight NSW public hospitals presenting to the hospital emergency department over a 10 day period. @entity0 completed a self-administered survey with demographic characteristics and questions about substance use. More than two-thirds (68%) of @entity0 consented to provide access to their NSW Health medical data for a period spanning 2.5 years. RESULTS: One-third (35%) of the total sample were identified as having problematic AOD use with one in five of these @entity0 requiring a high level of intervention. Those @entity0 requiring a high level of intervention present more often and cost more per presentation. If admitted they were more likely to have longer stays and were also more likely to be admitted to a @entity1 ward and have a longer stay in the ward. DISCUSSION: This study demonstrates a need for AOD interventions in the emergency department setting, both because it represents an opportunity for intervention in a population in which problems with substance use is highly prevalent, and because there is evidence that AOD imposes additional costs on the health system. [Butler K, Reeve R, Arora S, Viney R, Goodall S, van Gool K, Burns L. The hidden costs of drug and @entity2 use in hospital emergency departments. Drug @entity2 Rev 2016;35:359-366].

title: The hidden costs of drug and XXXX use in hospital emergency departments.

answer: @entity2


abstract: BACKGROUND:: The relationships between physical activity, cognition, and development of @entity2 represent an area of intense research interest. Meta-analyses and prospective cohort studies show that greater levels of physical activity are associated with lower @entity4 risk. Most studies, however, depend on self-report data that are subject to recall and other biases. Obtaining objective and quantitative physical activity data could strengthen observational study validity. OBJECTIVE:: To examine the association between objectively measured daytime activity and @entity1 ( @entity1 ) or @entity3 ( @entity3 ). METHODS:: The objective was addressed through the development of a structured, critically appraised topic. We incorporated a clinical scenario, background information, a structured question, literature search strategy, critical appraisal, results, evidence summary, commentary, and bottom line conclusions. @entity0 included consultant and resident neurologists, clinical epidemiologists, a medical librarian, and behavioral neurology and neuropsychiatry content experts. RESULTS:: We selected a prospective, single-center cohort study of 716 cognitively normal elderly @entity0 followed for 3.5 years. Greater levels of physical activity, as measured using wrist actigraphy, were associated with a lower risk of incident @entity1 or @entity3 (hazard ratio, 0.477; 95% confidence interval, 0.273-0.832). CONCLUSIONS:: Objective measurement confirms that greater levels of physical activity are associated with decreased risk of a future diagnosis of @entity1 or @entity3 . Further studies are needed to confirm the temporal association of exercise and future cognitive health and understand the relevant underlying biological mechanisms.

title: Physical Activity Level and Future Risk of Mild @entity1 or XXXX : A Critically Appraised Topic.

answer: @entity4


abstract: BACKGROUND:: The relationships between physical activity, cognition, and development of @entity2 represent an area of intense research interest. Meta-analyses and prospective cohort studies show that greater levels of physical activity are associated with lower @entity4 risk. Most studies, however, depend on self-report data that are subject to recall and other biases. Obtaining objective and quantitative physical activity data could strengthen observational study validity. OBJECTIVE:: To examine the association between objectively measured daytime activity and @entity1 ( @entity1 ) or @entity3 ( @entity3 ). METHODS:: The objective was addressed through the development of a structured, critically appraised topic. We incorporated a clinical scenario, background information, a structured question, literature search strategy, critical appraisal, results, evidence summary, commentary, and bottom line conclusions. @entity0 included consultant and resident neurologists, clinical epidemiologists, a medical librarian, and behavioral neurology and neuropsychiatry content experts. RESULTS:: We selected a prospective, single-center cohort study of 716 cognitively normal elderly @entity0 followed for 3.5 years. Greater levels of physical activity, as measured using wrist actigraphy, were associated with a lower risk of incident @entity1 or @entity3 (hazard ratio, 0.477; 95% confidence interval, 0.273-0.832). CONCLUSIONS:: Objective measurement confirms that greater levels of physical activity are associated with decreased risk of a future diagnosis of @entity1 or @entity3 . Further studies are needed to confirm the temporal association of exercise and future cognitive health and understand the relevant underlying biological mechanisms.

title: Physical Activity Level and Future Risk of Mild XXXX or @entity4 : A Critically Appraised Topic.

answer: @entity1


abstract: PURPOSE: Evaluate the efficacy and @entity3 of image guided brachytherapy using inverse planning simulated annealing (IPSA) high-dose-rate brachytherapy (HDRB) boost for locoregionally advanced @entity2 . METHODS AND MATERIALS: From December 2003 through September 2009, 111 @entity0 with @entity2 were treated definitively with IPSA-planned HDRB boost (28  Gy in 4 fractions) after external radiation at our institution. We performed a retrospective review of our experience using image guided brachytherapy. Of the @entity0 , 70% had a @entity2 size >4  cm, 38% had regional nodal disease, and 15% had clinically evident distant @entity1 , including nonregional nodal disease, at the time of diagnosis. Surgical staging involving pelvic lymph node dissection was performed in 15% of @entity0 , and 93% received concurrent @entity4 -based chemotherapy. @entity3 are reported according to the Common Terminology Criteria for Adverse Events version 4.0 guidelines. RESULTS: With a median follow-up time of 42  months (range, 3-84  months), no acute or late @entity3 of grade 4 or higher were observed, and grade 3 @entity3 (both acute and late) developed in 8 @entity0 (1 constitutional, 1 hematologic, 2 genitourinary, 4 gastrointestinal). The 4-year Kaplan-Meier estimate of late grade 3 @entity3 was 8%. Local recurrence developed in 5 @entity0 (4 to 9  months after HDRB), regional recurrence in 3 (6, 16, and 72  months after HDRB), and locoregional recurrence in 1 (4  months after HDR boost). The 4-year estimates of local, locoregional, and distant control of disease were 94.0%, 91.9%, and 69.1%, respectively. The overall and disease-free survival rates at 4  years were 64.3% (95% confidence interval [CI] of 54%-73%) and 61.0% (95% CI, 51%-70%), respectively. CONCLUSIONS: Definitive radiation by use of inverse planned HDRB boost for locoregionally advanced @entity2 is well tolerated and achieves excellent local control of disease. However, overall survival continues to be limited by the high rates of distant @entity1 .

title: Inverse Planned High-Dose-Rate Brachytherapy for Locoregionally Advanced Cervical XXXX : 4-Year Outcomes.

answer: @entity2


abstract: @entity3 (pVHL)-mediated ubiquitination of @entity7 plays a central role in the cellular responses to changes in @entity0 availability. In the present study, using @entity6 as a model, we showed that specific knockdown of endogenous @entity8 leads to @entity4 and @entity2 . Knockdown of @entity8 resulted in abnormal kidney development, including curved and cystic pronephric tubule or/and cystic and @entity5 . Co-injecting capped @entity8 messenger RNA (mRNA) partially rescued pronephros morphant phenotype, confirming the specificity of the morpholino oligonucleotide (MO)-induced @entity1 . In keeping with the pronephros phenotype, renal function was affected as well in @entity8 morphants. Dextran clearance abilities of @entity8 morphants were significantly reduced as compared with those of control embryos. Further analysis indicated that glomerular integrity is impaired in @entity8 morphants, while the organization of pronephric duct was minimally affected. @entity8 morphants display global increased vegf signaling and angiogenesis. In addition, we found that @entity8 morphants displayed elevated expression of vegfa in podocytes and increased angiogenesis at pronephric glomerulus and the nearby vessels. Treatment of vegf inducer to embryos also caused pronephros phenotype resembling @entity8 morphants, further supporting that increased vegfa signaling contribute to the pronephros morphant phenotype. Our study establishes the @entity6 as an alternative vertebrate model system for studying @entity8 function during kidney development.

title: @entity3 gene plays a role during XXXX pronephros development.

answer: @entity6


abstract: @entity3 (pVHL)-mediated ubiquitination of @entity7 plays a central role in the cellular responses to changes in @entity0 availability. In the present study, using @entity6 as a model, we showed that specific knockdown of endogenous @entity8 leads to @entity4 and @entity2 . Knockdown of @entity8 resulted in abnormal kidney development, including curved and cystic pronephric tubule or/and cystic and @entity5 . Co-injecting capped @entity8 messenger RNA (mRNA) partially rescued pronephros morphant phenotype, confirming the specificity of the morpholino oligonucleotide (MO)-induced @entity1 . In keeping with the pronephros phenotype, renal function was affected as well in @entity8 morphants. Dextran clearance abilities of @entity8 morphants were significantly reduced as compared with those of control embryos. Further analysis indicated that glomerular integrity is impaired in @entity8 morphants, while the organization of pronephric duct was minimally affected. @entity8 morphants display global increased vegf signaling and angiogenesis. In addition, we found that @entity8 morphants displayed elevated expression of vegfa in podocytes and increased angiogenesis at pronephric glomerulus and the nearby vessels. Treatment of vegf inducer to embryos also caused pronephros phenotype resembling @entity8 morphants, further supporting that increased vegfa signaling contribute to the pronephros morphant phenotype. Our study establishes the @entity6 as an alternative vertebrate model system for studying @entity8 function during kidney development.

title: XXXX gene plays a role during @entity6 pronephros development.

answer: @entity3


abstract: BACKGROUND: Inadequate relief of @entity1 is a major reason of increased occurrence of @entity2 . We aimed to investigate and compare the effects of transcutaneous electrical nerve stimulation (TENS) and @entity4 ( @entity4 ) to relieve @entity1 after thoracotomy procedures. MATERIALS AND METHODS: We studied 40 @entity0 who underwent thoracotomy. @entity0 were randomly allocated to receive either @entity4 (group P, n   =   20) or TENS (group T, n   =   20) for @entity3 . The electrodes of TENS were placed 2 cm under and 2 cm over the thoracotomy cut on both posterior and anterior sides. The surgeon inserted paravertebral catheters using direct vision at the end of the surgery. A @entity0 -controlled analgesia (PCA) device was connected to all @entity0 . Visual analog scales, @entity0 demand, and consumption of @entity5 were evaluated postoperatively. RESULTS: Mean visual analog scale (VAS) values were significantly lower in group P for all time points. The @entity0 in group P needed lower amounts of opioid ( @entity5 ) and the difference was statistically significant (258.4        13.52   mg vs. 314.4        8.65   mg, p   =   0.005). In addition, the number of demand attempts recorded from the PCA device was significantly lower in group P (14.95        13.64 vs. 26.7        17.34, respectively and p   <   0.001). CONCLUSION: TENS has beneficial effects for @entity1 relief after thoracotomy, without any side effects; however, it cannot provide sufficient @entity1 relief when compared with @entity4 .

title: Comparison of Transcutaneous Electrical Nerve Stimulation and Paravertebral Block for Postthoracotomy XXXX Relief.

answer: @entity1


abstract: OBJECTIVE: To evaluate changes in absolute lymphocyte counts, lymphocyte subsets, and @entity2 in @entity0 treated with @entity9 ( @entity8 ) in comparison to the baseline pre- @entity8 levels. METHODS: A retrospective chart review was conducted of 23 @entity1 @entity0 treated with @entity8 . Absolute lymphocyte counts and lymphocyte subsets were obtained at baseline and after at least 3 months of @entity8 treatment. Data on @entity2 requiring medical attention were also collected. RESULTS: A total of 23 @entity0 were included in this analysis, 11 male (48%), 12 female (52%), with a mean age of 44.5  14.1 years, disease duration of 13.7  8.9 years, and EDSS of 3.5  1.7. The time between baseline and treatment lymphocyte counts was 3.9  1.2 months. Significant reductions in absolute lymphocyte counts by 35% (p<0.0001), CD3(+) by 34% (p<0.0001), @entity4 (+) by 34% (p<0.0001), @entity5 (+) by 40% (p<0.0001), and @entity6 (+) counts by 48% (p=0.0098) were found. Grade 2 @entity7 occurred in 24% of @entity0 and grade 3 @entity7 occurred in 1 @entity0 . @entity2 occurred in 26% of @entity0 , mainly as @entity3 (22%) and one fatal case of @entity10 in a @entity0 with grade 3 @entity7 , who had been on @entity8 for 5 months. A detailed summary of this fatal case is provided. CONCLUSION: Lymphocyte subsets may help to provide better understanding of immunologic and safety impact of @entity8 .

title: Effects of XXXX on lymphocyte subsets.

answer: @entity9


abstract: UNASSIGNED: Myeloid cells are an essential part of the @entity3 microenvironment. However, in @entity4 the function of these immune cells is not sufficiently clarified. In our study, we investigated differential pro-angiogenic activities of resident microglia and peripheral macrophages and their impact on @entity2 vascularization and progression. Our data demonstrate stable accumulation of microglia/macrophages during @entity0 growth. These cells often interact with @entity0 blood vessels correlating with @entity5 . Here, we identified resident microglia as well as peripheral macrophages as part of the perivascular niche, primarily contacting endothelial cells. We found overexpression of a variety of pro-angiogenic molecules within freshly isolated microglia/macrophages from @entity2 . @entity7 , until now a poorly described chemokine, was strongly up-regulated and showed better angiogenic activity than @entity1 in vitro. Blocking the @entity7 - @entity6 signaling pathway resulted in considerably diminished @entity2 sizes. Additionally, the importance of microglia/macrophages in @entity0 angiogenesis was confirmed by depletion of these cells in vivo. Vessel density decreased by 50  % leading to significantly smaller @entity0 volumes. Remarkably, selective reduction of resident microglia affected tumoral vessel count comparable to ablation of the whole myeloid cell fraction. These results provide evidence that resident microglia are the crucial modulatory cell population playing a central role in regulation of vascular homeostasis and angiogenesis in @entity4 . Thus, resident microglia represent an alternative source of pro-angiogenic growth factors and cytokines.

title: Resident microglia rather than peripheral macrophages promote vascularization in XXXX and are source of alternative pro-angiogenic factors.

answer: @entity4


abstract: UNASSIGNED: @entity6 ( @entity6 ) located at the craniocervical junction are rare @entity5 with distinctive features, and their natural history and the optimal treatment strategy remains unclear. We retrospectively reviewed eight @entity0 with craniocervical junction DAVF who were evaluated at our institution between 2009 and 2012. We also conducted a MEDLINE search for all reports of craniocervical junction DAVF between 1970 and 2013, and reviewed 119 @entity0 from 56 studies. From a total of 127 @entity0 , 46 (37.1%) presented with @entity3 , 53 (43.1%) with @entity2 ( @entity2 ), and four (3.3%) with @entity1 . @entity2 was typically mild, most often Hunt and Hess Grade I or II (83.3%), and associated with ascending venous drainage via the intracranial veins (p<0.001). Higher rates of obliteration were observed after microsurgery compared to embolization. Overall, younger age (odds ratio [OR] 1.07; 95% confidence interval [CI] 1.01-1.12; p=0.011), hemorrhagic presentation (OR 0.17; 95% CI 0.06-0.50; p=0.001), and microsurgery (OR 0.23; 95% CI 0.08-0.6; p=0.004) were independently predictive of good outcome at the last follow-up. Microsurgery was the only independent predictor of overall improvement at the last follow-up (OR 4.35; 95% CI 1.44-13.2; p=0.009). Prompt diagnosis and microsurgical management, offering a greater chance of immediate obliteration, may optimize the outcomes for @entity0 with craniocervical junction DAVF. Endovascular treatment is often not feasible due to lesion angioarchitecture, and is associated with a higher risk of lesion recanalization or recurrence. However, long term studies with newer @entity4 such as Onyx (ev3 Endovascular, Plymouth, MN, USA) are yet to be performed.

title: Natural history and treatment of XXXX .

answer: @entity6


abstract: PURPOSE: Knee function, whether anterior cruciate ligament (ACL)-deficient or ACL-reconstructed, is related to many conditions, and no single biomechanical variable can be used to definitively assess knee performance. The purpose of this study was to investigate the relationship between extension and flexion muscle strength and knee function in @entity0 prior and following ACL reconstruction. METHODS: 44 @entity2 @entity0 with a mean age of 26.6  years were tested between 3 and 6  months following an @entity1 and 2  years following ACL reconstruction. All reconstructed @entity0 underwent surgical reconstruction within 6  months of ACL injury using bone-patellar tendon and interference screws. The Cincinnati knee rating system was used to assess knee function. Muscle strength was assessed with the Biodex    Dynamometer. Isokinetic concentric and eccentric flexion and extension peak torque (Nm/kg) was tested at three different speeds: 60  /s, 120  /s and 180  /s. Isometric strength was tested in 30   and 60   of knee flexion. Both the involved and non-involved legs were tested to calculate symmetry indices. RESULTS: The mean Cincinnati score in the @entity2 @entity0 was 62.0      14.5 (range 36-84) and increased to 89.3      9.5 (range 61-100) in the ACL-reconstructed @entity0 . Significant relationships between knee function and muscle strength in the @entity2 group were observed for knee symmetry indices (r  =  0.38-0.50, p  =  0.0001-0.05). In the ACL-reconstructed group significant relationships between knee functionality were observed for isometric and isokinetic peak torque of the involved limb (r  =  0.46-0.71, p  =  0.0001-0.007). CONCLUSION: The findings of this study suggest that neither extension nor flexion peak torque were correlates of knee function in the @entity2 knee. However, leg symmetry indices were correlated to knee function. In the ACL-reconstructed knee, knee symmetry indices were not related to knee function but extension and flexion isokinetic concentric and isometric peak torque were.

title: Strength does not influence knee function in the XXXX knee but is a correlate of knee function in the and ACL-reconstructed knee.

answer: @entity2


abstract: AIMS: To study the prognostic effect of @entity4 on outcome of cardiac resynchronization therapy (CRT). METHODS AND RESULTS: @entity0 receiving a CRT device in the University Medical Centre Groningen were included. @entity4 was defined as a >= 10% reduction in left atrial volume index at 6-month follow-up. Success of CRT was defined as ventricular reverse remodelling with a reduction in left ventricular end-systolic volume of >= 15% at 6-month follow-up. Primary endpoint was all-cause mortality or @entity1 hospitalizations. A total of 365 @entity0 (mean age 65.1    11.0 years, 73% @entity0 ) were included; among them, 221 (61%) were in sinus rhythm and had no prior @entity2 ( @entity2 ), and 144 @entity0 (39%) had a history of @entity2 . During a mean follow up of 2.0    1.0 years, 49 @entity0 died. Cox regression analysis revealed that @entity0 with no atrial and no ventricular reverse remodelling had the worst outcome (hazard ratio 3.1, 95% confidence interval 1.4-7.1, P = 0.006). Outcome in @entity0 with only @entity4 was comparable with outcome in @entity0 with both @entity3 (hazard ratio 2.0, 95% confidence interval 0.7-5.6, P = 0.21). CONCLUSION: @entity0 without @entity3 have the worst outcome. @entity0 with only @entity4 have improved left ventricular diastolic filling during follow-up and demonstrate a comparable outcome with @entity0 with both @entity3 . Assessment of @entity4 may provide additional prognostic information in determining CRT outcome.

title: XXXX is associated with outcome of cardiac resynchronization therapy   .

answer: @entity4


abstract: OBJECTIVE: To study the safety profile and characterize the immunologic effects of high- vs low-dose @entity3 supplementation in @entity0 with @entity1 ( @entity1 ). METHODS: In this double-blind, single-center randomized pilot study, 40 @entity0 with relapsing-remitting @entity1 were randomized to receive 10,400 IU or 800 IU @entity3 daily for 6 months. Assessments were performed at baseline and 3 and 6 months. RESULTS: Mean increase of @entity4 levels from baseline to final visit was larger in the high-dose group (34.9 ng/mL; 95% confidence interval [CI] 25.0-44.7 ng/mL) than in the low-dose group (6.9 ng/mL; 95% CI 1.0-13.7 ng/mL). Adverse events were minor and did not differ between the 2 groups. Two relapses occurred, one in each treatment arm. In the high-dose group, we found a reduction in the proportion of interleukin-17(+) @entity2 (+) T cells (p = 0.016), CD161(+) @entity2 (+) T cells (p = 0.03), and effector memory @entity2 (+) T cells (p = 0.021) with a concomitant increase in the proportion of central memory @entity2 (+) T cells (p = 0.018) and naive @entity2 (+) T cells (p = 0.04). These effects were not observed in the low-dose group. CONCLUSIONS: @entity3 supplementation with 10,400 IU daily is safe and tolerable in @entity0 with @entity1 and exhibits in vivo pleiotropic immunomodulatory effects in @entity1 , which include reduction of interleukin-17 production by @entity2 (+) T cells and decreased proportion of effector memory @entity2 (+) T cells with concomitant increase in central memory @entity2 (+) T cells and naive @entity2 (+) T cells. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that @entity3 supplementation with 10,400 IU daily is safe and well-tolerated in @entity0 with @entity1 and exhibits in vivo pleiotropic immunomodulatory effects.

title: Safety and immunologic effects of high- vs low-dose @entity3 in XXXX .

answer: @entity1


abstract: OBJECTIVE: To study the safety profile and characterize the immunologic effects of high- vs low-dose @entity3 supplementation in @entity0 with @entity1 ( @entity1 ). METHODS: In this double-blind, single-center randomized pilot study, 40 @entity0 with relapsing-remitting @entity1 were randomized to receive 10,400 IU or 800 IU @entity3 daily for 6 months. Assessments were performed at baseline and 3 and 6 months. RESULTS: Mean increase of @entity4 levels from baseline to final visit was larger in the high-dose group (34.9 ng/mL; 95% confidence interval [CI] 25.0-44.7 ng/mL) than in the low-dose group (6.9 ng/mL; 95% CI 1.0-13.7 ng/mL). Adverse events were minor and did not differ between the 2 groups. Two relapses occurred, one in each treatment arm. In the high-dose group, we found a reduction in the proportion of interleukin-17(+) @entity2 (+) T cells (p = 0.016), CD161(+) @entity2 (+) T cells (p = 0.03), and effector memory @entity2 (+) T cells (p = 0.021) with a concomitant increase in the proportion of central memory @entity2 (+) T cells (p = 0.018) and naive @entity2 (+) T cells (p = 0.04). These effects were not observed in the low-dose group. CONCLUSIONS: @entity3 supplementation with 10,400 IU daily is safe and tolerable in @entity0 with @entity1 and exhibits in vivo pleiotropic immunomodulatory effects in @entity1 , which include reduction of interleukin-17 production by @entity2 (+) T cells and decreased proportion of effector memory @entity2 (+) T cells with concomitant increase in central memory @entity2 (+) T cells and naive @entity2 (+) T cells. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that @entity3 supplementation with 10,400 IU daily is safe and well-tolerated in @entity0 with @entity1 and exhibits in vivo pleiotropic immunomodulatory effects.

title: Safety and immunologic effects of high- vs low-dose XXXX in @entity1 .

answer: @entity3


abstract: BACKGROUND AND OBJECTIVES: Trisomy 21 is known to decrease the risk of several (nonocular) angiogenic-mediated diseases. The objective of this study was to determine whether trisomy 21 can also be shown to be significantly protective against ocular angiogenic-mediated disorders such as @entity1 (ROP). METHODS: A retrospective analysis of deidentified data from the Pediatrix BabySteps Clinical Warehouse. This large repository of neonatal data is approved for use in research studies by the Western Institutional Review Board. The study population consisted of 99,080 @entity0 with very low birth weights (BWs; BW <1500 g), born between 1996 and 2013, cared for at >300 US NICUs, and who had been discharged alive from hospital. Statistical significance for unadjusted comparisons between groups was determined with Pearson's   (2) test or Student's t test. Logistic regression models were used to calculate the odds of ROP (of any stage) and advanced ROP (stage 3 or greater) for @entity0 with trisomy 21 compared with all other @entity0 . RESULTS: The prevalence of trisomy 21 was 0.3% in the study population (321 of 99,080). After adjustment for BW, gestational age, oxygen exposure, and other potential confounders, there was an odds ratio of 0.6 (95% confidence interval: 0.5-0.8) for ROP in @entity0 with trisomy 21compared with other @entity0 and an odds ratio of 0.4 (95% confidence interval: 0.1-0.9) for advanced-stage ROP. CONCLUSIONS: Trisomy 21 significantly decreases the odds for ROP in very low BW @entity0 survivors. This study unmasks a potentially identifiable genetic component to ROP risk, paving the way for the development of a laboratory-based ROP screening tool.

title: Trisomy 21 and Risk of XXXX .

answer: @entity1


abstract: UNASSIGNED: The present study was designed to evaluate the beneficial effects of Withania somnifera (WS) pre-supplementation on @entity8 ( @entity8 ) model of @entity5 . @entity5 was induced in the @entity0 by inserting intraluminal suture for 90  min, followed by reperfusion injury for 24  h. The animals were assessed for locomotor functions (by neurological deficit scores, narrow beam walk and rotarod test), cognitive and @entity4 -like behavioural functions (by morris water maze and elevated plus maze test). @entity8 animals showed significant @entity3 . Neurobehavioural changes were accompanied by decreased acetylcholinesterase activity, increased oxidative stress in terms of enhanced lipid peroxidation and lowered @entity6 levels in the @entity8 animals. In addition, @entity8 animals had @entity5 and the presence of pycnotic nuclei. Single-photon emission computerized tomography (SPECT) of @entity8 animals revealed a @entity5 as a hypoactive area. On the other hand, pre-supplementation with WS (300  mg/kg body weight) for 30  days to @entity8 animals was effective in restoring the acetylcholinesterase activity, lipid peroxidation, @entity7 and attenuated @entity8 . WS significantly reduced the @entity5 and ameliorated histopathological alterations. Improved blood flow was observed in the SPECT images from the brain regions of @entity1 @entity0 pre-treated with WS. The results of the study showed a protective effect of WS supplementation in @entity5 and are suggestive of its potential application in @entity2 management.

title: Propensity of Withania somnifera to Attenuate Behavioural, Biochemical, and Histological Alterations in Experimental Model of XXXX .

answer: @entity2


abstract: UNASSIGNED: Background The relative efficacy and safety of intravitreous aflibercept, bevacizumab, and ranibizumab in the treatment of @entity3 are unknown. Methods At 89 clinical sites, we randomly assigned 660 adults (mean age, 61  10 years) with @entity3 involving the macular center to receive intravitreous aflibercept at a dose of 2.0 mg (224 @entity0 ), bevacizumab at a dose of 1.25 mg (218 @entity0 ), or ranibizumab at a dose of 0.3 mg (218 @entity0 ). The study drugs were administered as often as every 4 weeks, according to a protocol-specified algorithm. The primary outcome was the mean change in visual acuity at 1 year. Results From baseline to 1 year, the mean @entity2 letter score (range, 0 to 100, with higher scores indicating better visual acuity; a score of 85 is approximately 20/20) improved by 13.3 with aflibercept, by 9.7 with bevacizumab, and by 11.2 with ranibizumab. Although the improvement was greater with aflibercept than with the other two drugs (P<0.001 for aflibercept vs. bevacizumab and P=0.03 for aflibercept vs. ranibizumab), it was not clinically meaningful, because the difference was driven by the eyes with worse visual acuity at baseline (P<0.001 for interaction). When the initial @entity2 letter score was 78 to 69 (equivalent to approximately 20/32 to 20/40) (51% of @entity0 ), the mean improvement was 8.0 with aflibercept, 7.5 with bevacizumab, and 8.3 with ranibizumab (P>0.50 for each pairwise comparison). When the initial letter score was less than 69 (approximately 20/50 or worse), the mean improvement was 18.9 with aflibercept, 11.8 with bevacizumab, and 14.2 with ranibizumab (P<0.001 for aflibercept vs. bevacizumab, P=0.003 for aflibercept vs. ranibizumab, and P=0.21 for ranibizumab vs. bevacizumab). There were no significant differences among the study groups in the rates of serious adverse events (P=0.40), hospitalization (P=0.51), @entity1 (P=0.72), or major cardiovascular events (P=0.56). Conclusions Intravitreous aflibercept, bevacizumab, or ranibizumab improved vision in eyes with center-involved @entity3 , but the relative effect depended on baseline visual acuity. When the initial @entity2 was mild, there were no apparent differences, on average, among study groups. At worse levels of initial visual acuity, aflibercept was more effective at improving vision. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT01627249 .).

title: Aflibercept, Bevacizumab, or Ranibizumab for XXXX .

answer: @entity3


abstract: UNASSIGNED: A major cause of @entity3 after @entity6 virus infection is @entity5 due to a bacterial superinfection, yet the mechanism is unknown. @entity3 has been attributed to virus-induced immunosuppression and @entity10 , but this hypothesis is based on data from the preantibiotic era and animal models that omit antimicrobial therapy. Because of diagnostic uncertainty, most @entity0 with @entity6 receive antibiotics, making @entity10 unlikely. @entity9 after superinfection presents as acute @entity4 , a disorder characterized by lung microvascular leak and @entity1 . The objective of this study was to determine whether the @entity6 virus sensitizes the lung endothelium to leak upon exposure to circulating bacterial-derived molecular patterns from @entity8 . In vitro as well as in vivo models of @entity6 followed by @entity8 superinfection were used. Molecular mechanisms were explored using molecular biology, knockout @entity2 , and @entity0 autopsy specimens. @entity7 sensitized @entity0 lung endothelium to leak when challenged with @entity8 , even at low doses of @entity6 and even when the pathogens were given days apart. Influenza virus increased endothelial expression of @entity11 both in vitro and in intact lungs, a finding corroborated by @entity0 autopsy specimens of @entity0 with @entity6 . Leak was recapitulated with protein A, a @entity11 ligand, and sequential infection caused protein A-dependent loss of IkB, cleavage of @entity12 , and lung endothelial apoptosis. @entity2 infected sequentially with @entity6 virus and @entity8 developed significantly @entity1 that was protein A and @entity11 dependent. Influenza virus primes the lung endothelium to leak, predisposing @entity0 to acute @entity4 upon exposure to @entity8 .

title: Influenza-Induced Priming and Leak of @entity0 Lung Microvascular Endothelium upon Exposure to XXXX .

answer: @entity8


abstract: UNASSIGNED: A major cause of @entity3 after @entity6 virus infection is @entity5 due to a bacterial superinfection, yet the mechanism is unknown. @entity3 has been attributed to virus-induced immunosuppression and @entity10 , but this hypothesis is based on data from the preantibiotic era and animal models that omit antimicrobial therapy. Because of diagnostic uncertainty, most @entity0 with @entity6 receive antibiotics, making @entity10 unlikely. @entity9 after superinfection presents as acute @entity4 , a disorder characterized by lung microvascular leak and @entity1 . The objective of this study was to determine whether the @entity6 virus sensitizes the lung endothelium to leak upon exposure to circulating bacterial-derived molecular patterns from @entity8 . In vitro as well as in vivo models of @entity6 followed by @entity8 superinfection were used. Molecular mechanisms were explored using molecular biology, knockout @entity2 , and @entity0 autopsy specimens. @entity7 sensitized @entity0 lung endothelium to leak when challenged with @entity8 , even at low doses of @entity6 and even when the pathogens were given days apart. Influenza virus increased endothelial expression of @entity11 both in vitro and in intact lungs, a finding corroborated by @entity0 autopsy specimens of @entity0 with @entity6 . Leak was recapitulated with protein A, a @entity11 ligand, and sequential infection caused protein A-dependent loss of IkB, cleavage of @entity12 , and lung endothelial apoptosis. @entity2 infected sequentially with @entity6 virus and @entity8 developed significantly @entity1 that was protein A and @entity11 dependent. Influenza virus primes the lung endothelium to leak, predisposing @entity0 to acute @entity4 upon exposure to @entity8 .

title: Influenza-Induced Priming and Leak of XXXX Lung Microvascular Endothelium upon Exposure to @entity8 .

answer: @entity0


abstract: PURPOSE: To compare the morphology and minimum apparent diffusion coefficient (ADC) values among @entity0 subtypes. METHODS: Ninety-three @entity1 , who underwent breast MRI and collectively had 98 pathologically proven invasive @entity3 , were enrolled. Morphology was evaluated according to BIRADS-MRI. Minimum ADC was measured. Morphology and minimum ADC were compared among subtypes. Multivariate logistic regression analyses were used to identify the characteristics associated with different subtypes. RESULTS: Oval/round shape was significantly associated with @entity2 ( @entity5 vs. @entity5 : 90.9% vs. 45.2%; p=0.0123). Rim enhancement was significantly less frequent in Luminal A (Luminal A vs. non-Luminal A: 34.2% vs. 76.1%; p=0.0003). The minimum ADC of Luminal A was significantly higher than that of Luminal B ( @entity6 -negative) (834 vs. 748*10(-6)mm(2)/s; p<0.025). The minimum ADC of the @entity5 -special type was significantly higher than that of @entity4 (997 vs. 702*10(-6)mm(2)/s; p<0.025). On the multivariate analysis comparing the characteristics associated with Luminal A vs. Luminal B ( @entity6 -negative), the internal enhancement characteristics of the mass and minimum ADC were significant factors. CONCLUSION: Morphology and minimum ADC would be useful in distinguishing @entity0 subtypes.

title: Differences in morphological features and minimum apparent diffusion coefficient values among XXXX subtypes using 3-tesla MRI.

answer: @entity0


abstract: UNASSIGNED: There is increasing demand for cryopreserved cells such as liver and pancreatic cells for clinical applications. Cryopreservation at ultra-low temperatures requires use of cryoprotectants (e.g. @entity3 ( @entity3 )) to maintain cell integrity during freezing and thawing processes. Standard cryoprotectants are cytotoxic and more effective cryopreservation technologies are urgently needed for long-term storage of cells. As an alternative, soluble protein extracts (WPE) from winter @entity2 successfully replaced @entity3 as a cryoprotectant for several @entity0 cell types. To identify novel cryoactive proteins, the WPE was separated by chromatography and cryoactive fractions were analysed by mass spectrometry. The @entity2 protein 2- @entity1 peroxiredoxin BAS1 (renamed TaBAS1) was identified as a potential cryoactive candidate. Recombinant proteins were prepared and found to possess dual functions as a peroxidase antioxidant and molecular chaperone, and display cryoprotective properties for hepatocytes and insulin-secreting INS832/13 cells. Following cryopreservation with TaBAS1, cells were plateable and showed high post-thaw viability, good adhesion properties and well-maintained cell-specific metabolic functions. The overall quality of these cell types was equivalent or improved compared to cells that were cryopreserved with @entity3 . The antioxidant and chaperone functions of TaBAS1 likely explain its efficacy in reducing oxidative/nitrosative stresses in cryopreserved cells. The plant protein TaBAS1 could be a promising molecule to include in cryostorage protocols. This article is protected by copyright. All rights reserved.

title: Plant protein 2- XXXX peroxiredoxin TaBAS1 alleviates oxidative and nitrosative stresses incurred during cryopreservation of @entity0 cells.

answer: @entity1


abstract: UNASSIGNED: There is increasing demand for cryopreserved cells such as liver and pancreatic cells for clinical applications. Cryopreservation at ultra-low temperatures requires use of cryoprotectants (e.g. @entity3 ( @entity3 )) to maintain cell integrity during freezing and thawing processes. Standard cryoprotectants are cytotoxic and more effective cryopreservation technologies are urgently needed for long-term storage of cells. As an alternative, soluble protein extracts (WPE) from winter @entity2 successfully replaced @entity3 as a cryoprotectant for several @entity0 cell types. To identify novel cryoactive proteins, the WPE was separated by chromatography and cryoactive fractions were analysed by mass spectrometry. The @entity2 protein 2- @entity1 peroxiredoxin BAS1 (renamed TaBAS1) was identified as a potential cryoactive candidate. Recombinant proteins were prepared and found to possess dual functions as a peroxidase antioxidant and molecular chaperone, and display cryoprotective properties for hepatocytes and insulin-secreting INS832/13 cells. Following cryopreservation with TaBAS1, cells were plateable and showed high post-thaw viability, good adhesion properties and well-maintained cell-specific metabolic functions. The overall quality of these cell types was equivalent or improved compared to cells that were cryopreserved with @entity3 . The antioxidant and chaperone functions of TaBAS1 likely explain its efficacy in reducing oxidative/nitrosative stresses in cryopreserved cells. The plant protein TaBAS1 could be a promising molecule to include in cryostorage protocols. This article is protected by copyright. All rights reserved.

title: Plant protein 2- @entity1 peroxiredoxin TaBAS1 alleviates oxidative and nitrosative stresses incurred during cryopreservation of XXXX cells.

answer: @entity0


abstract: OBJECTIVES: To investigate the prevalence of in-stent restenosis (ISR) in @entity0 with various @entity2 blood types. METHODS: Clinical information from 150 @entity0 with a confirmed diagnosis of ISR and 150 @entity0 with a diagnosis of patent coronary stents in the secondary angiography was collected. Comprehensive demographic and laboratory data, including @entity2 and Rhesus blood groups, as well as comorbid conditions and vessel and stent characteristics, were recorded for each @entity0 . The association of @entity2 blood groups with the risk of ISR before and after controlling for coronary risk factors was determined. Categorical data were analyzed with the Chi-square test and numerical values were analyzed with t-tests. Binary logistic regression models were constructed to compare type A and non-A for the frequency of risk factors. RESULTS: A total of 392 stents were implanted in 300 @entity0 . Two hundred and fourteen stents (54.6%) were patent and 178 stents (45.4%) were stenosed. Blood group A was significantly more common in the ISR group (43.3% vs. 28.7%, p=0.03). However, the frequencies of other blood types, as well as Rh antigen, were similar between the two groups. @entity1 and low-density lipoproteins were the only significantly different variables (221    198 mg/dL vs. 138    76 mg/dL, p<0.001 and 108    36 mg/dL vs. 96    73 mg/dL, p=0.04, in type-A vs. non-A, respectively). After matching for coronary risk factors, there was no difference between A blood type @entity0 and their controls. CONCLUSION: ISR is significantly more prevalent in individuals with the type A blood group. However, this higher association is most likely due to higher atherogenic conditions in @entity0 within this population.

title: Association of XXXX blood types with the risk of in-stent restenosis.

answer: @entity2


abstract: OBJECTIVE: The aim of the present study was to analyse demographic and clinical characteristics, as well as @entity1 diagnoses to identify gender differences in @entity0 with attempted suicide in a Mexican population. METHODS: Between September 2010 and September 2012, 140 suicide attempts were documented in the Department of Psychiatry at the General Hospital of Comalcalco (Hospital General de Comalcalco in Spanish) in Tabasco, Mexico. Diagnoses were established using the DSM-IV questionnaire in which Axis I and II were considered. The Suicide Intent Scale was also applied. RESULTS: In our sample, 63.6% were females and 36.4% males. With regard to socio-demographic characteristics, the predominant marital status in males was single, and in females married (  2=5.93, df=2, p=0.05). In occupation the male group was mainly unemployed and housewife in females (  2=55.51, df=4, p<0.001). Male subjects were more likely to consume alcohol (  2=20.40, df=1, p <=0.001), @entity4 (  2=16.62, df=1, p <=0.001) or @entity2 . The prevalence of @entity1 diagnosis was significantly different because, the male group was mainly diagnosed with @entity3 , whereas female @entity0 showed a prevalence of stress-related disorders (  2=34.17, gl=4, p=0.0001). CONCLUSION: Our results provide evidence that the characteristics of suicide attempt are different by gender in the Mexican population. Interventions are necessary for the development of prevention strategies that may lead to a reduction in suicidal behaviour. These preventive activities should consider the occupation for the female group and consumption of alcohol, @entity4 or @entity2 in the male group.

title: Gender differences in socio-demographic, clinical characteristics and XXXX diagnosis in/of suicide attempters in a Mexican population.

answer: @entity1


abstract: OBJECTIVE: To evaluate the association between the clinical activity of @entity1 patients and serum adipocytokines ( @entity4 , @entity5 and @entity8 ) and inflammatory cytokines. METHODS: All @entity1 @entity0 fulfilled ACR 1987 criteria and were treated with DMARDs. Adipocytokine and inflammatory cytokine levels were evaluated using ELISA. RESULTS: 121 @entity0 were included in the study. Stratifying according to DAS28 (low, moderate and high activity), there were significant differences for @entity4 , @entity8 , @entity3 and @entity7 , however, no differences were seen for @entity5 , @entity2 or @entity6 . Clinical activity positively correlated with @entity4 , @entity8 , @entity7 and @entity3 levels, but not with @entity5 , @entity2 or @entity6 . @entity5 levels negatively correlated with @entity2 and positively correlated with @entity6 . @entity6 positively correlated with @entity3 and negatively correlated with @entity2 and @entity7 . CONCLUSION: Circulating @entity4 , @entity8 , @entity3 and @entity7 levels positively correlate with @entity1 clinical activity in a manner independent of the subject's BMI. Complex relationships between inflammatory cytokines were observed in @entity1 @entity0 suggesting that other metabolic or inflammatory factors could be involved.

title: Peripheral blood @entity4 and @entity8 levels as clinical activity biomarkers in Mexican XXXX @entity0 .

answer: @entity1


abstract: OBJECTIVE: To evaluate the association between the clinical activity of @entity1 patients and serum adipocytokines ( @entity4 , @entity5 and @entity8 ) and inflammatory cytokines. METHODS: All @entity1 @entity0 fulfilled ACR 1987 criteria and were treated with DMARDs. Adipocytokine and inflammatory cytokine levels were evaluated using ELISA. RESULTS: 121 @entity0 were included in the study. Stratifying according to DAS28 (low, moderate and high activity), there were significant differences for @entity4 , @entity8 , @entity3 and @entity7 , however, no differences were seen for @entity5 , @entity2 or @entity6 . Clinical activity positively correlated with @entity4 , @entity8 , @entity7 and @entity3 levels, but not with @entity5 , @entity2 or @entity6 . @entity5 levels negatively correlated with @entity2 and positively correlated with @entity6 . @entity6 positively correlated with @entity3 and negatively correlated with @entity2 and @entity7 . CONCLUSION: Circulating @entity4 , @entity8 , @entity3 and @entity7 levels positively correlate with @entity1 clinical activity in a manner independent of the subject's BMI. Complex relationships between inflammatory cytokines were observed in @entity1 @entity0 suggesting that other metabolic or inflammatory factors could be involved.

title: Peripheral blood XXXX and @entity8 levels as clinical activity biomarkers in Mexican @entity1 @entity0 .

answer: @entity4


abstract: OBJECTIVE: To evaluate the association between the clinical activity of @entity1 patients and serum adipocytokines ( @entity4 , @entity5 and @entity8 ) and inflammatory cytokines. METHODS: All @entity1 @entity0 fulfilled ACR 1987 criteria and were treated with DMARDs. Adipocytokine and inflammatory cytokine levels were evaluated using ELISA. RESULTS: 121 @entity0 were included in the study. Stratifying according to DAS28 (low, moderate and high activity), there were significant differences for @entity4 , @entity8 , @entity3 and @entity7 , however, no differences were seen for @entity5 , @entity2 or @entity6 . Clinical activity positively correlated with @entity4 , @entity8 , @entity7 and @entity3 levels, but not with @entity5 , @entity2 or @entity6 . @entity5 levels negatively correlated with @entity2 and positively correlated with @entity6 . @entity6 positively correlated with @entity3 and negatively correlated with @entity2 and @entity7 . CONCLUSION: Circulating @entity4 , @entity8 , @entity3 and @entity7 levels positively correlate with @entity1 clinical activity in a manner independent of the subject's BMI. Complex relationships between inflammatory cytokines were observed in @entity1 @entity0 suggesting that other metabolic or inflammatory factors could be involved.

title: Peripheral blood @entity4 and XXXX levels as clinical activity biomarkers in Mexican @entity1 @entity0 .

answer: @entity8


abstract: OBJECTIVE: To evaluate the association between the clinical activity of @entity1 patients and serum adipocytokines ( @entity4 , @entity5 and @entity8 ) and inflammatory cytokines. METHODS: All @entity1 @entity0 fulfilled ACR 1987 criteria and were treated with DMARDs. Adipocytokine and inflammatory cytokine levels were evaluated using ELISA. RESULTS: 121 @entity0 were included in the study. Stratifying according to DAS28 (low, moderate and high activity), there were significant differences for @entity4 , @entity8 , @entity3 and @entity7 , however, no differences were seen for @entity5 , @entity2 or @entity6 . Clinical activity positively correlated with @entity4 , @entity8 , @entity7 and @entity3 levels, but not with @entity5 , @entity2 or @entity6 . @entity5 levels negatively correlated with @entity2 and positively correlated with @entity6 . @entity6 positively correlated with @entity3 and negatively correlated with @entity2 and @entity7 . CONCLUSION: Circulating @entity4 , @entity8 , @entity3 and @entity7 levels positively correlate with @entity1 clinical activity in a manner independent of the subject's BMI. Complex relationships between inflammatory cytokines were observed in @entity1 @entity0 suggesting that other metabolic or inflammatory factors could be involved.

title: Peripheral blood @entity4 and @entity8 levels as clinical activity biomarkers in Mexican @entity1 XXXX .

answer: @entity0


abstract: Purpose: This study investigated setup error and effectiveness of weekly image-guided radiotherapy (IGRT) of TomoDirect for early @entity0 . Materials and Methods: One hundred and fifty-one breasts of 147 consecutive @entity1 who underwent breast conserving surgery (BCS) followed by whole breast irradiation using TomoDirect in 2012 and 2013 were evaluated. All @entity1 received weekly IGRT. The weekly setup errors from simulation to each treatment in reference to chest wall and surgical clips were measured. Random, systemic, and three-dimensional setup errors were assessed. Extensive setup error was defined as 5 mm above the margin in any directions. Results: All mean errors were within 3 mm of all directions. The mean angle of gantry shifts was 0.6   . The mean value of absolute three-dimensional setup error was 4.67 mm. In multivariate analysis, breast size (OR=2.82, 95% of CI: 1.00-7.90) was a significant factor for extensive error. The largest significant deviation of setup error was observed in the first week of radiotherapy (p<0.001) and the deviations gradually decreased with time. The deviation of setup error was 5.68 mm in the first week and within 5 mm after the second week. Conclusion: In this study, there was a significant association between breast size and significant setup error in @entity0 @entity1 who received TomoDirect. The largest deviation occurred in the first week of treatment. Therefore, @entity1 with large breasts should be closely observed on every fraction and fastidious attention is required in the first fraction of IGRT.

title: Setup Error and Effectiveness of Weekly Image-Guided Radiation Therapy of TomoDirect for Early XXXX .

answer: @entity0


abstract: INTRODUCTION: The genus Ligustrum (Oleaceae) is distributed in Europe and Asia (south China and Korea), where it is used to prevent @entity2 , sore throats, @entity1 and @entity0 . The main groups of compounds in extracts of Ligustrum vulgare are biologically active @entity9 and @entity8 . OBJECTIVES: The aim of the study was primarily the development and validation of a HPTLC-photodensitometry method for separation and determination of @entity9 ( @entity10 , @entity7 ) and @entity8 ( @entity11 ) in different extracts prepared from leaves of L. vulgare. A secondary issue was the quantitative screening of @entity10 , @entity7 and @entity11 in extracts from leaves collected at different stages of plant growth (from May to September). METHODS: A HPTLC-photodensitometry method was developed and validated for quantification of @entity7 , @entity10 and @entity11 in plant extracts (aqueous and ethanolic extract, decoction, infusion). @entity6 was used as the stationary phase and @entity4 : @entity3 : @entity5 :water (80:25:1.5:4, v/v/v/v) as the mobile phase. RESULTS: The HPTLC-photodensitometry method developed for quantification of @entity10 , @entity7 and @entity11 was specific, accurate and precise. The presence of @entity10 was detected in aqueous extracts, whereas @entity7 was present, in particular, in ethanolic extracts, decoctions and infusions. @entity11 was detected in all the extracts prepared. The content of @entity9 was variable from May to September, whereas the amount of @entity11 increased in this term. CONCLUSION: The developed and validated HPTLC-photodensitometry method allowed performing fast screening of quantitative profiles of @entity10 , @entity7 and @entity11 in preparations of privet leaves. Copyright    2015 John Wiley _ Sons, Ltd.

title: Quantitative Determination of XXXX and @entity8 in Different Extracts of Ligustrum Vulgare L. Leaves by a Validated HPTLC-Photodensitometry Method.

answer: @entity9


abstract: INTRODUCTION: The genus Ligustrum (Oleaceae) is distributed in Europe and Asia (south China and Korea), where it is used to prevent @entity2 , sore throats, @entity1 and @entity0 . The main groups of compounds in extracts of Ligustrum vulgare are biologically active @entity9 and @entity8 . OBJECTIVES: The aim of the study was primarily the development and validation of a HPTLC-photodensitometry method for separation and determination of @entity9 ( @entity10 , @entity7 ) and @entity8 ( @entity11 ) in different extracts prepared from leaves of L. vulgare. A secondary issue was the quantitative screening of @entity10 , @entity7 and @entity11 in extracts from leaves collected at different stages of plant growth (from May to September). METHODS: A HPTLC-photodensitometry method was developed and validated for quantification of @entity7 , @entity10 and @entity11 in plant extracts (aqueous and ethanolic extract, decoction, infusion). @entity6 was used as the stationary phase and @entity4 : @entity3 : @entity5 :water (80:25:1.5:4, v/v/v/v) as the mobile phase. RESULTS: The HPTLC-photodensitometry method developed for quantification of @entity10 , @entity7 and @entity11 was specific, accurate and precise. The presence of @entity10 was detected in aqueous extracts, whereas @entity7 was present, in particular, in ethanolic extracts, decoctions and infusions. @entity11 was detected in all the extracts prepared. The content of @entity9 was variable from May to September, whereas the amount of @entity11 increased in this term. CONCLUSION: The developed and validated HPTLC-photodensitometry method allowed performing fast screening of quantitative profiles of @entity10 , @entity7 and @entity11 in preparations of privet leaves. Copyright    2015 John Wiley _ Sons, Ltd.

title: Quantitative Determination of @entity9 and XXXX in Different Extracts of Ligustrum Vulgare L. Leaves by a Validated HPTLC-Photodensitometry Method.

answer: @entity8


abstract: INTRODUCTION: The Expanded Prostate Cancer Index Composite (EPIC) is a validated and widely adopted instrument that measures @entity0 quality of life. This study aims to describe and compare @entity0 quality of life in the bowel, urinary, and @entity1 treatments. MATERIALS AND METHODS: A systematic review of English articles published prior to 2012 was conducted. Peer reviewed articles reporting longitudinal EPIC data in a statistically analyzable form with clearly defined time points were included. Articles were assessed by content experts to ensure optimal treatment quality. Screening of studies and extraction of data were completed using a predefined data abstraction tool. Data on bowel, urinary, and sexual domains were documented. Scores in each domain range from a low of 0 to a high of 100. RESULTS: Twenty-six articles, representing 8302 @entity0 , were included. All treatments were associated with short term or long term reductions in urinary, bowel, and sexual domains. Surgery @entity0 had better post-treatment bowel quality of life; however, average declines were small regardless of treatment. Post-treatment urinary incontinence scores were lower for surgery @entity0 ; while radiation @entity0 had worse urinary irritation. Average urinary bother and function were similar between treatment groups at 18 months post-treatment. Surgery @entity0 had better baseline sexual function. A greater decline in sexual function was observed in surgery @entity0 compared to radiation @entity0 . CONCLUSIONS: @entity1 treatments have different impacts on @entity0 quality of life and function. The magnitude of difference between treatment-related adverse effects may be important to @entity0 when choosing therapy.

title: A systematic review of expanded XXXX index composite (EPIC) quality of life after surgery or radiation treatment.

answer: @entity1


abstract: INTRODUCTION: To describe our technique for robot-assisted radical nephrectomy (RARN) with inferior vena cava (IVC) @entity1 thrombectomy and to present initial results for our first two @entity0 . MATERIALS AND METHODS: Two @entity0 with renal masses with infrahepatic IVC extension underwent RARN with IVC @entity1 thrombectomy using a four-arm configuration. Both cases were right-sided @entity1 . Vascular control was obtained with complete cross-clamping of the vena cava with robotic bulldog clamps. Intraoperative ultrasound was used to delineate extent of @entity1 extension. Specimens were removed en-bloc, and the IVC was closed with 2-layers of 4-0 @entity4 . The specimen is extracted through a lower midline incision. RESULTS: Two robotic IVC thrombectomies were successfully completed. There were no conversions, @entity3 . Median operative time was 243 minutes with a median estimated @entity2 of 150 mL. Both @entity0 were able to ambulate independently free of intravenous opioids on postoperate day 1. Median length of stay was 4.5 (range 3-6) days. Final pathology revealed @entity5 in both cases with negative surgical margins. CONCLUSIONS: Robotic technology may facilitate RN and IVC thrombectomy in the well selected @entity0 and appears to be a safe and feasible approach.

title: Robot-assisted radical nephrectomy with inferior vena cava XXXX thrombectomy: technique and initial outcomes.

answer: @entity1