abstract: Telomere-led chromosome movements are a conserved feature of meiosis I (MI) prophase. Several roles have been proposed for such chromosome motion, including promoting homolog pairing and removing inappropriate chromosomal interactions. Here, we provide evidence in budding @entity1 that rapid chromosome movements affect homolog pairing and recombination. We found that @entity4 /\ strains, which are defective for telomere-led chromosome movements, show defects in homolog pairing as measured in a "one-dot/two-dot tetR-GFP" assay; however, pairing in @entity4 /\ eventually reaches near wild-type (WT) levels. Charged-to- @entity2 scanning mutagenesis of @entity4 yielded one allele, @entity4 -3, that confers a @entity4 /\-like delay in meiotic prophase but promotes high spore viability. The meiotic delay in @entity4 -3 strains is essential for spore viability because a null mutation ( @entity3 /\) in the @entity3 checkpoint protein suppresses the delay but confers a severe spore viability defect. @entity4 -3 mutants show a general defect in chromosome motion but an intermediate defect in chromosome pairing. Chromosome velocity analysis in live cells showed that while average chromosome velocity was strongly reduced in @entity4 -3, chromosomes in this mutant displayed occasional rapid movements. Lastly, we observed that @entity0 mutants displaying lower levels of meiosis-induced double-strand breaks showed higher spore viability in the presence of the @entity4 -3 mutation compared to @entity4 /\. On the basis of these observations, we propose that during meiotic prophase the presence of occasional fast moving chromosomes over an extended period of time is sufficient to promote WT levels of recombination and high spore viability; however, sustained and rapid chromosome movements are required to prevent a checkpoint response and promote efficient meiotic progression.

title: Sustained and rapid chromosome movements are critical for chromosome pairing and meiotic progression in budding XXXX .

answer: @entity1


abstract: OBJECTIVE: To define the frequency and clinical and immunologic characteristics of @entity0 affected by @entity1 ( @entity1 ) and @entity3 . METHODS: @entity0 fulfilling the criteria for @entity1 associated with @entity3 collected from the European Commission-funded @entity1 Euronetwork group database were analyzed. RESULTS: Fifty-three @entity0 with @entity4 ( @entity4 ) (24 @entity0 , mean age 51, range 16-84) or @entity5 ( @entity5 ) (29 @entity0 , mean age 64, range 31-82) and @entity1 were analyzed. The most commonly associated @entity1 was @entity8 , present in 21 cases, with a higher prevalence in @entity4 (16/24 cases). Peripheral nervous system (mainly demyelinating @entity6 ) and motor neuron involvement were more common in @entity5 . Onconeural antibodies were more frequent in @entity0 with @entity8 , most commonly against the Tr antigen. Fifty percent of the @entity0 with @entity1 and @entity4 responded to chemotherapy, whereas neurologic improvement was less frequent (24%) in @entity0 with @entity1 and @entity5 . In both groups, the survival rate was good. Overall, 10 out of 53 @entity0 eventually died, with only 2 @entity0 (1 with @entity4 , 1 with @entity5 ) dying from @entity1 . CONCLUSIONS: @entity1 in @entity0 with @entity3 are relatively rare. @entity8 , mainly associated with anti-Tr antibodies, is more prevalent in @entity4 and @entity5 , followed in our study by motor @entity2 in @entity0 with @entity5 . Involvement of the peripheral nervous system is heterogeneous, with a prevalence of @entity7 in @entity0 with @entity5 .

title: Spectrum of paraneoplastic disease associated with XXXX .

answer: @entity3


abstract: OBJECTIVE: To build mathematical models for evaluating the individual risk of @entity4 in @entity0 with @entity2 and a thick endometrium using clinical data, sonographic endometrial thickness and power Doppler ultrasound findings. METHODS: A total of 117 @entity0 underwent transvaginal two-dimensional gray-scale and power Doppler ultrasound examination of the endometrium before getting endometrial biopsy. Inclusion criteria were @entity2 and a thick endometrium greater than 5mm. The ultrasound image showing the most vascularized section through the endometrium as assessed by power Doppler was frozen to estimate endometrial thickness and features. The vascularity index was calculated using computer software. A structured history was taken to collect clinical information. Multivariate logistic regression analysis was used to create mathematical models to predict @entity4 . RESULTS: There were 31 (26.4%) malignant and 86 (74.6%) benign endometria    @entity0 with a malignant endometrium were older (median age 61 vs 56years, P=0.036) and had a thicker endometrium (median thickness 18.8mm vs 12.5; P=0.002) and higher values for vascularity index. When using only clinical data to build a model for estimating the risk of @entity4 , a model including the variables age had the largest area under the receiver-operating characteristics curve (AUC), with a value of 0.69 (95% confidence interval [CI], 0.59-0.79). A model including age and endometrial thickness had an AUC of 0.72 (95% CI, 0.50-0.96), and one including age, endometrial thickness and vascularity index had an AUC of 0.91 (95% CI, 0.62-0.97). Using a risk cut-off of 12%, the latter model had sensitivity 89%, specificity 74%, positive likelihood ratio 3.42 and negative likelihood ratio 0.14. DISCUSSION: @entity2 is a frequent cause of consultation in gynecological particularly in peri- or post-menopausal period. They are the main alarm sign of @entity3 . Vaginal ultrasound has become the "gold standard" in the initial exploration. It is a powerful tool to estimate the individual risk of @entity1 in symptomatic postmenopausal @entity0 in order to optimize the management. The diagnostic performance of models predicting @entity3 increases substantially when sonographic and power Doppler information are added to clinical variables. This model seems to be clinically useful but need to be prospectively validated.

title: [Value of ultrasonography to predict the @entity3 in XXXX ].

answer: @entity2


abstract: OBJECTIVE: To build mathematical models for evaluating the individual risk of @entity4 in @entity0 with @entity2 and a thick endometrium using clinical data, sonographic endometrial thickness and power Doppler ultrasound findings. METHODS: A total of 117 @entity0 underwent transvaginal two-dimensional gray-scale and power Doppler ultrasound examination of the endometrium before getting endometrial biopsy. Inclusion criteria were @entity2 and a thick endometrium greater than 5mm. The ultrasound image showing the most vascularized section through the endometrium as assessed by power Doppler was frozen to estimate endometrial thickness and features. The vascularity index was calculated using computer software. A structured history was taken to collect clinical information. Multivariate logistic regression analysis was used to create mathematical models to predict @entity4 . RESULTS: There were 31 (26.4%) malignant and 86 (74.6%) benign endometria    @entity0 with a malignant endometrium were older (median age 61 vs 56years, P=0.036) and had a thicker endometrium (median thickness 18.8mm vs 12.5; P=0.002) and higher values for vascularity index. When using only clinical data to build a model for estimating the risk of @entity4 , a model including the variables age had the largest area under the receiver-operating characteristics curve (AUC), with a value of 0.69 (95% confidence interval [CI], 0.59-0.79). A model including age and endometrial thickness had an AUC of 0.72 (95% CI, 0.50-0.96), and one including age, endometrial thickness and vascularity index had an AUC of 0.91 (95% CI, 0.62-0.97). Using a risk cut-off of 12%, the latter model had sensitivity 89%, specificity 74%, positive likelihood ratio 3.42 and negative likelihood ratio 0.14. DISCUSSION: @entity2 is a frequent cause of consultation in gynecological particularly in peri- or post-menopausal period. They are the main alarm sign of @entity3 . Vaginal ultrasound has become the "gold standard" in the initial exploration. It is a powerful tool to estimate the individual risk of @entity1 in symptomatic postmenopausal @entity0 in order to optimize the management. The diagnostic performance of models predicting @entity3 increases substantially when sonographic and power Doppler information are added to clinical variables. This model seems to be clinically useful but need to be prospectively validated.

title: [Value of ultrasonography to predict the XXXX in @entity2 ].

answer: @entity3


abstract: INTRODUCTION: Symptomatic extramedullary hematopoiesis (EH) is a rare but potentially severe phenomenon which occurs in @entity5 . There are no treatment guidelines. METHODS: Retrospective single centre study including the cases of symptomatic EH encountered between 1997 and 2014 in a unit specialised in red @entity1 . Description of clinical, biological and radiological characteristics of the @entity0 , treatments received, and outcomes. RESULTS: Among 182 @entity5 @entity0 followed during the study period, 7  cases of symptomatic EH were diagnosed. They were 5  @entity0 and 2  @entity0 , and their mean age was 37  years. Four @entity0 were splenectomised, two @entity0 were regularly transfused, and four @entity0 had already received @entity2 . EH was localised in intravertebral areas and responsible for dorsal @entity3 in 5  @entity0 , in paravertebral dorsal area in 1  @entity0 , and in presacral area in 1  @entity0 . The mean hemoglobin level at diagnosis was 7.9  g/dL. Treatment administered included: red cell transfusion in 6 cases, associated with @entity4 in 5 cases and/or radiotherapy in 3  @entity0 . One @entity0 was treated with surgery and HU. After a median follow-up of 41  months, clinical recovery was complete in 2  @entity0 and partial in 5  @entity0 . CONCLUSION: EH must be suspected in @entity5 in @entity0 presenting clinical signs of organ compression, and a typical radiological aspect. The functional prognosis depends on the rapidity of treatment, which includes red blood cell transfusion, @entity4 , radiotherapy, and rarely surgery. Long-term outcome is uncertain.

title: [Symptomatic extramedullary haematopoiesis in XXXX : A retrospective single centre study].

answer: @entity5


abstract: A technique for extended ambulatory @entity2 control after lumbar discectomy is described; preliminary results with 45 @entity0 are reported; and alternative methods of narcotic @entity5 are reviewed. In this technique, an absorbable gelatin sponge (Gelfoam, Upjohn Co., Kalamazoo, MI) is contoured to the laminotomy defect, placed in @entity8 (40-80 mg), and then injected with 2 to 4 mg of preservative-free @entity4 (a small needle was used to fill the sponge). The sponge is placed over the defect before closure. A review of office and hospital records was conducted. The series consisted of 33 @entity0 and 12 @entity0 (mean age, 39 yr; range, 24-57 yr); records showed narcotic use in 34 @entity0 (parenteral in 3) and work-related @entity1 in 14 @entity0 . Thirty-three @entity0 were ambulatory postoperatively on the day of surgery; all were ambulatory by postoperative day (POD) 1. On the day of surgery, 18 @entity0 did not require any postoperative analgesics; on @entity3 , 22 @entity0 did not require analgesics. Six @entity0 received parenteral narcotics; four received one dose only, and two had two or more doses. Thirty-one @entity0 were discharged from the hospital on @entity3 , and 10 were discharged POD 2. The other @entity0 were discharged from the hospital on POD 3 (three @entity0 ) or POD 4 (one @entity0 ). When they were discharged, all @entity0 received a limited supply of @entity6 with codeine for @entity2 control at home. After discharge, phone follow-up (at 1 week) and office follow-ups (at 3-5 weeks) revealed only one @entity0 with more than mild discomfort. Three @entity0 required one-time bladder catheterization, and one @entity0 had presumed @entity7 1 month postoperatively. In a control group who had undergone surgery 3 months previously, the average day of discharge had been POD 3.07; no control @entity0 had been discharged on @entity3 , and only 20% had been discharged on POD 2. This method provides effective, safe, and extended @entity5 after lumbar discectomy.

title: Lumbar discectomy: use of an epidural XXXX sponge for postoperative pain control.

answer: @entity4


abstract: The success of maintenance haemodialysis in the 1960s was blighted by the problem of @entity4 . Treatment with @entity1 , @entity6 , @entity8 and transfusions did no more than minimize its effects. The need for a renewable source of @entity5 was appreciated very early but the hope took 25 years to realize. Cloning and expression of the @entity0 gene was achieved in 1984 and clinical trials planned even before the descriptions of the recombinant hormone were published. The Amgen material was tested in parallel studies in Seattle and England and by the end of 1986 the efficacy of recombinant @entity0 @entity5 (r-HuEPO) given in large intravenous bolus doses in reversing the @entity4 of uraemia was established. The benefits were immediately obvious: relief from transfusion dependence was the unequivocal evidence but the effect on 'wellbeing' though subjective was remarkable. Large clinical trials were completed in Europe and the USA so that r-HuEPO was licensed as a therapeutic drug less than two years later. The pilot studies flagged a number of key issues: @entity3 , sometimes with @entity2 , occurred in @entity0 whose blood pressure was labile before treatment; vascular access failure seemed more frequent and hyperkalaemia was thought to reflect less efficient dialysis. Failure to respond focused attention on @entity1 balance as well as on factors such as infection, @entity9 , and @entity7 . A more clear understanding of the pathogenesis of the @entity4 of uraemia was made possible by dissection of the specific effects of the exogenous @entity5 on erythroid function.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Historical review on the use of recombinant @entity0 XXXX in chronic renal failure.

answer: @entity5


abstract: The success of maintenance haemodialysis in the 1960s was blighted by the problem of @entity4 . Treatment with @entity1 , @entity6 , @entity8 and transfusions did no more than minimize its effects. The need for a renewable source of @entity5 was appreciated very early but the hope took 25 years to realize. Cloning and expression of the @entity0 gene was achieved in 1984 and clinical trials planned even before the descriptions of the recombinant hormone were published. The Amgen material was tested in parallel studies in Seattle and England and by the end of 1986 the efficacy of recombinant @entity0 @entity5 (r-HuEPO) given in large intravenous bolus doses in reversing the @entity4 of uraemia was established. The benefits were immediately obvious: relief from transfusion dependence was the unequivocal evidence but the effect on 'wellbeing' though subjective was remarkable. Large clinical trials were completed in Europe and the USA so that r-HuEPO was licensed as a therapeutic drug less than two years later. The pilot studies flagged a number of key issues: @entity3 , sometimes with @entity2 , occurred in @entity0 whose blood pressure was labile before treatment; vascular access failure seemed more frequent and hyperkalaemia was thought to reflect less efficient dialysis. Failure to respond focused attention on @entity1 balance as well as on factors such as infection, @entity9 , and @entity7 . A more clear understanding of the pathogenesis of the @entity4 of uraemia was made possible by dissection of the specific effects of the exogenous @entity5 on erythroid function.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Historical review on the use of recombinant XXXX @entity5 in chronic renal failure.

answer: @entity0


abstract: UNASSIGNED: The purpose of this study is to assess the feasibility of using the analytical technique of ultrasound images in combination with an @entity0 localization system. During respiration, the activity of breathing in and out causes organs displacement at the lower lobe of the lung, and the maximum displacement range happens in the Superior-Inferior (SI) direction. Therefore, in this study all the @entity0 positioning is in SI direction under @entity1 , in which the compensations are carried out to the organs at the lower lobe and adjacent to the lower lobe of lung.In this research, due to the processes of ultrasound imaging generation, image analysis and signal transmission, when the captured respiratory signals are sent to @entity0 localization system, there was a signal time delay. The total delay time of the entire signal transmission process was 0.254    0.023 seconds (with the lowest standard deviation) after implementing a series of analyses. To compensate for this signal delay time (0.254    0.023 sec), a phase lead compensator (PLC) was designed and built into the @entity0 localization system. By analyzing the impact of the delay time and the respiratory waveforms under different frequencies on the phase lead compensator, an overall system delay time can be configured. Results showed as the respiratory frequency increased, variable value   a'' and the subsequent gain   k'' in the controller becomes larger. Moreover, value   a'' and   k'' increased as the system delay time increased when the respiratory frequency was fixed. The relationship of value   a'' and   k'' to the respiratory frequency can be obtained by using the curve fitting method to compensate for the respiratory motion for @entity0 localization. Through the comparison of the uncompensated signal and the compensated signal performed by the @entity0 localization system on the simulated respiratory signal, the feasibility of using ultrasound image analysis technology combined with the developed @entity0 localization system can be evaluated. The results show that the simulated respiratory signals under different frequencies of 0.5, 0.333, 0.25, 0.2 and 0.167 Hz with phase lead compensators were improved and stabilized. The compensation rate increased to the range of 7.04      18.82%, and the final compensation rate is about 97%. Therefore the @entity0 localization system combined with the ultrasound image analysis techniques is feasible.In this study, the developed ultrasound image analysis techniques combined into the @entity0 localization system has the following four advantages: (1) It is a non-invasive way (ultrasonic images) to monitor the entire compensating process of the active respiration instead of using a C-arm (invasive) to observe the organs motion. (2) During radiation therapy, the whole treatment process can be continuous, which can save the overall treatment time. (3) It is an independent system, which can be mounted onto any treatment couch. (4) Users can operate this system easily without the need of prior complicated training process.

title: The feasibility of the auto tuning XXXX system with ultrasonic image tracking technique.

answer: @entity1


abstract: @entity0 with severe chronic @entity2 were treated with intermittent @entity1 infusions administered on an outpatient basis with a portable infusion device. Eleven @entity0 (eight @entity0 and three @entity0 ), ages 28-71 years, were given initial @entity1 infusions at a rate of 1-2 micrograms/kg/min, and the dose was gradually increased to a maximum dose of 15 micrograms/kg/min. @entity0 were considered @entity1 responders if their cardiac output increased by at least 30% and pulmonary-capillary wedge pressure did not rise. After a sustained hemodynamic response was demonstrated, the infusion was discontinued to assess the @entity0 ' symptoms during drug-free intervals. The @entity0 were instructed and trained in proper catheter care after a venous-access catheter was surgically implanted. @entity0 were also shown how to use the ambulatory infusion pump. The @entity0 were treated with long-term intermittent @entity1 infusions for 3-24 months. All @entity0 adjusted easily to the routine of catheter and pump care and drug administration. The mean dose of @entity1 resulting in the maximum improvement in cardiac index was 9.4 micrograms/kg/min. All @entity0 observed an improvement in their symptoms of @entity2 during the drug infusions and the intervals between the infusions. There was a mean reduction of 1.2 in New York Heart Association functional class. There were 18 @entity2 -related hospital readmissions among the 11 @entity0 during 108 cumulative months of long-term @entity1 therapy. The intermittent administration of @entity1 via a portable infusion system appears to have improved the functional capacity of the 11 @entity0 studied. This may be a viable treatment alternative for selected ambulatory @entity0 with severe @entity2 who demonstrate hemodynamic improvement with @entity1 .

title: Intermittent @entity1 infusions in outpatients with chronic XXXX .

answer: @entity2


abstract: @entity0 with severe chronic @entity2 were treated with intermittent @entity1 infusions administered on an outpatient basis with a portable infusion device. Eleven @entity0 (eight @entity0 and three @entity0 ), ages 28-71 years, were given initial @entity1 infusions at a rate of 1-2 micrograms/kg/min, and the dose was gradually increased to a maximum dose of 15 micrograms/kg/min. @entity0 were considered @entity1 responders if their cardiac output increased by at least 30% and pulmonary-capillary wedge pressure did not rise. After a sustained hemodynamic response was demonstrated, the infusion was discontinued to assess the @entity0 ' symptoms during drug-free intervals. The @entity0 were instructed and trained in proper catheter care after a venous-access catheter was surgically implanted. @entity0 were also shown how to use the ambulatory infusion pump. The @entity0 were treated with long-term intermittent @entity1 infusions for 3-24 months. All @entity0 adjusted easily to the routine of catheter and pump care and drug administration. The mean dose of @entity1 resulting in the maximum improvement in cardiac index was 9.4 micrograms/kg/min. All @entity0 observed an improvement in their symptoms of @entity2 during the drug infusions and the intervals between the infusions. There was a mean reduction of 1.2 in New York Heart Association functional class. There were 18 @entity2 -related hospital readmissions among the 11 @entity0 during 108 cumulative months of long-term @entity1 therapy. The intermittent administration of @entity1 via a portable infusion system appears to have improved the functional capacity of the 11 @entity0 studied. This may be a viable treatment alternative for selected ambulatory @entity0 with severe @entity2 who demonstrate hemodynamic improvement with @entity1 .

title: Intermittent XXXX infusions in outpatients with chronic @entity2 .

answer: @entity1


abstract: On consultation, @entity3 ( @entity3 ) was offered to @entity0 with @entity4 ( @entity4 ) to determine the mode and site of delivery prior to labour. Between January 1989 and December 1993, 41 pregnant @entity0 underwent @entity3 . All @entity0 had a history of @entity4 , a platelet count less than 90 K, (+) antiplatelet antibody, and/or @entity2 diagnosed early in pregnancy. @entity3 was performed at term except in one @entity0 with @entity5 , who underwent @entity3 at 31 weeks' gestation. @entity0 with fetal platelet counts greater than 50 K returned to their referring physician for delivery. Records were complete in 39 pregnancies. Fetal blood was successfully obtained in 37 of 39 cases (95 per cent). Fetal platelet counts correlated with neonatal platelet counts in 36 of 37 cases (97 per cent). The interval between @entity3 and delivery ranged from 0 to 31 days. Six of 37 fetuses (16 per cent) had significant @entity2 (< 50 K). These six @entity0 underwent Caesarean section. Vaginal delivery was recommended in all others. There were two procedure-related complications. There were no cases of @entity1 in any of the neonates. In conclusion, there is a high incidence of @entity2 in @entity0 with @entity4 . @entity3 reliably detects @entity2 and is therefore useful in the perinatal planning of the mode and site of delivery.

title: The role of XXXX in the management of @entity4 .

answer: @entity3


abstract: On consultation, @entity3 ( @entity3 ) was offered to @entity0 with @entity4 ( @entity4 ) to determine the mode and site of delivery prior to labour. Between January 1989 and December 1993, 41 pregnant @entity0 underwent @entity3 . All @entity0 had a history of @entity4 , a platelet count less than 90 K, (+) antiplatelet antibody, and/or @entity2 diagnosed early in pregnancy. @entity3 was performed at term except in one @entity0 with @entity5 , who underwent @entity3 at 31 weeks' gestation. @entity0 with fetal platelet counts greater than 50 K returned to their referring physician for delivery. Records were complete in 39 pregnancies. Fetal blood was successfully obtained in 37 of 39 cases (95 per cent). Fetal platelet counts correlated with neonatal platelet counts in 36 of 37 cases (97 per cent). The interval between @entity3 and delivery ranged from 0 to 31 days. Six of 37 fetuses (16 per cent) had significant @entity2 (< 50 K). These six @entity0 underwent Caesarean section. Vaginal delivery was recommended in all others. There were two procedure-related complications. There were no cases of @entity1 in any of the neonates. In conclusion, there is a high incidence of @entity2 in @entity0 with @entity4 . @entity3 reliably detects @entity2 and is therefore useful in the perinatal planning of the mode and site of delivery.

title: The role of @entity3 in the management of XXXX .

answer: @entity4


abstract: INTRODUCTION: @entity4 ( @entity4 ), also known as @entity7 , is a rare disease most frequently occurring in @entity0 with @entity5 ( @entity5 ). The clinical picture is typically characterized by very painful @entity2 and @entity6 following calcification and occlusion of small cutaneous arterioles. @entity4 is life-threatening due to @entity3 and concomitant @entity1 . METHODS: We performed a literature search for the terms @entity7 and @entity4 and summarized current state-of-the-art knowledge about pathophysiology, clinical picture, course of the disease, as well as treatment options. We have filled out the literature data with our personal treatment experiences. RESULTS: A combination of various local and systemic risk factors are necessary to cause the development of @entity7 . This pathophysiological cascade is still incompletely understood. @entity0 with advanced @entity5 and dialysis @entity0 are especially at risk to develop @entity4 . Regarding therapy, no randomized prospective trials are available, and treatment is rather based on pathophysiological considerations as well as on evidence derived from case reports or case series. Therapy focuses on optimized dialysis treatment, control of @entity5 parameters, experimental anticalcification strategies and wound care. CONCLUSION: Facing the still deleterious outcome of @entity0 with @entity7 , further studies on prophylaxis as well as treatment are urgently needed. Current treatment strategies may help ameliorate the course of the disease in some @entity0 . However, it is still unclear if they are able to decrease mortality.

title: XXXX : a still unmet challenge.

answer: @entity7


abstract: BACKGROUND: The purpose of this study is to evaluate the risk of subsequent local recurrence (LR) and survival of @entity3 ( @entity3 ) @entity0 who underwent re-excision after intralesional excision. METHODS: We analyzed clinical outcomes of 11 @entity3 @entity0 referred after intralesional excision. Average follow-up was 86 months (range: 37-190 months). There were 9 Stage IB lesions and 2 Stage IIB lesions. @entity2 were located in the femur (3) and in other locations (8). Seven @entity0 showing recurrent @entity2 at referral received entire segmental excision while remaining four @entity0 without LR underwent hemi-cortical excision. RESULTS: The 5-year @entity1 free survival rate of 11 @entity0 was 81.8%. @entity0 without evident @entity2 mass did not show further recurrence after re-excision. However, 5 (71.4%) of the 7 @entity0 with recurrent @entity2 relapsed despite segmental re-excision, and their median interval to subsequent LR was 18.8 months (range: 4-9 months). Two of five @entity0 with re-recurrence developed @entity1 which were unresponsive to chemotherapy. CONCLUSIONS: Following inadvertent intralesional procedure, re-excision should be liberally applied before there is an evidence of recurrence. In @entity0 presenting with gross LR, amputation should not be spared unless wide surgical margin can be achieved.

title: Outcome of re-excision for intralesionally treated XXXX .

answer: @entity3


abstract: The Danish @entity0 Insurance Society (Patientforsikringsforeningen) was established by law in July 1992. The aim was to provide a just system of compensation for complications following medical treatment, that are not caused by culpous actions or omissions. The first 34 case records concerning position-related @entity3 were reviewed. The material has national coverage. The exact incidence of position related @entity3 in Denmark is unknown, but transitory @entity2 after otherwise uncomplicated surgical procedures are probably not infrequent complications. The material includes 17 males and 17 females. Position-related injury most often affects the peroneal nerve, followed by the ulnar nerve and lesions to the brachial plexus. The etiology is often difficult to establish precisely, and may often be multifactorial. In our material the main reason is believed to be direct pressure to the nerve in 76% of cases. Predisposition (e.g. subclinical @entity2 or @entity1 ) often complicates the case, but neurophysiological examination and the relation in time between an operation and the onset of @entity2 often clarifies the etiology.

title: [Posture-related injuries and XXXX insurance].

answer: @entity0


abstract: A careful history points the urodynamic examination in the right direction and enables the examiner to ask the correct questions. The individual who does the test is the only reliable interpreter of the results of that study. No urodynamic technique is as sensitive or specific as a blood @entity2 , or even an electrocardiogram. A history of urgency and urge @entity1 suggests uninhibited contractility and is a better index of that condition than a cystometrogram. Leakage occurring shortly after a previous operative procedure for @entity5 suggests @entity5 . A past history of radiation, prior pelvic surgery, @entity0 , @entity4 , or prior chemotherapy all require a simple cystometrogram to rule out abnormal bladder compliance. Following a simple history and urodynamic evaluation, a physical examination should be performed, searching for urethra @entity6 . Abdominal leak-point pressure testing is useful to assign broad categories of @entity1 . Relatively high leak-point pressures with @entity7 suggest suspension operations will be effective. @entity3 with @entity7 often require a sling, and very low leak-point pressures with no @entity7 indicate a suitable candidate for a trial of injection therapy.

title: Urodynamic evaluation of XXXX .

answer: @entity5


abstract: PURPOSE: To assess the distributions of stress, strain, and @entity1 areas using a finite element model (FEM), and examine the @entity3 histopathologically in @entity2 of the femoral head. METHODS: Three femoral heads were obtained during hip arthroplasty for femoral @entity0 . One sample with a normal area, two samples with a non-sclerotic boundary without collapse (Type 1), two samples with a non-collapsed sclerotic boundary (Type 2), and two samples with a collapsed sclerotic boundary (Type 3) were collected from each femoral head for the FEM and histopathological analyses. FEM was performed using CT data, and the distributions of von Mises equivalent stress, octahedral shear stress, @entity4 , and simulated @entity1 area were evaluated. Furthermore, the osteoclast count at the boundary was compared for each type. RESULTS: In normal and Type 1 samples, the distributions of von Mises equivalent stress, octahedral shear stress, @entity4 , and the @entity1 area were equally concentrated along the whole analytical range; however, in the Type 2 and 3 samples, they were concentrated along the thickened bone trabeculae at the boundary, which corresponded to the @entity1 area. Histopathologically, a significantly increased osteoclast number was observed only at the collapsed sclerotic boundary. CONCLUSION: These results demonstrated that both shear stress and @entity4 tend to be concentrated on thickened bone trabeculae at the boundary. Fracture analyses revealed that the boundary of sclerotic changes, which results from the repair process, may be the starting point of the @entity1 . Additionally, the @entity3 increases after collapse.

title: The role of sclerotic changes in the starting mechanisms of collapse: A histomorphometric and FEM study on the femoral head of XXXX .

answer: @entity2


abstract: Necrophagous insects are valuable tools for postmortem interval (PMI) estimation or for determining the cause of @entity1 . Due to the increase in deaths related to @entity2 , it is crucial to know how these substances affect the development of flies that feed on corpses, to avoid errors in the PMI estimates. This study evaluated the effect of @entity4 , an anabolic androgenic @entity0 , on the development ofimmatures of Chrysomya megacephala (F.), @entity6 (Wiedemann), and Chrysomya albiceps (Wiedemann) (Diptera:Calliphoridae) when added to an artificial rearing diet. Four experimental groups were delineated: three of them were given diets containing 4.5, 22.5, or 45 mg/kg @entity4 ; and a drug-free control group. Weights were recorded at 12-h intervals from larval eclosion to pupation. No statistically significant differences were observed in mean larval weights, emergence interval, or emergence rates for all groups. However, differences in the three species were observed during the larval development. Initially, @entity6 reared in the highest concentration of decanoate showed greater @entity3 . However, at older ages, immatures reached lower mean weights than the control group. For C. albiceps, the highest concentration of @entity5 contributed to an effective lack of @entity3 during almost the entire course of larval development. Therefore, the influence of any drug on development should always be considered.

title: Effect of XXXX on the development of three species of Chrysomya (Diptera:Calliphoridae), flies of forensic importance in Brazil.

answer: @entity4


abstract: BACKGROUND: The @entity4 (delivery before 37 weeks gestation) is a major contributor to the global burden of @entity7 and @entity1 . The cause of @entity4 is complex, multifactorial, and likely dependent, at least in part, on the gestational age of the fetus. Intrauterine @entity2 is frequent in preterm deliveries that occur at <32 weeks gestation; understanding how the fetus responds to proinflammatory insult will be an important step towards early @entity4 prevention. However, animal studies of @entity2 and @entity0 in prematurity commonly use older fetuses that possess comparatively mature immune systems. OBJECTIVE: Aiming to characterize acute fetal responses to microbial agonist at a clinically relevant gestation, we used 92-day-old fetuses (62% of term) to develop a chronically catheterized @entity5 model of very preterm pregnancy. We hypothesized that any acute fetal systemic inflammatory responses would be driven by signaling from the tissues exposed to @entity3 lipopolysaccharide that is introduced into the amniotic fluid. STUDY DESIGN: Eighteen ewes that were carrying a single fetus at 92 days of gestation had recovery surgery to place fetal tracheal, jugular, and intraamniotic catheters. Animals were recovered for 24 hours before being administered either intraamniotic @entity3 lipopolysaccharide (n  = 9) or sterile saline solution (n  = 9). Samples were collected for 48 hours before euthanasia and necroscopy. Fetal inflammatory responses were characterized by microarray analysis, quantitative polymerase chain reaction, and enzyme-linked immunosorbent assay. RESULTS: Intraamniotic lipopolysaccharide reached the distal @entity6 within 2 hours. @entity10 increased tracheal fluid @entity9 within 2 hours and generated a robust inflammatory response that was characterized by @entity8 signaling pathway activation and up-regulation of cell proliferation but no increases in inflammatory mediator expression in cord blood RNA. CONCLUSIONS: In very preterm @entity5 fetuses, lipopolysaccharide stimulates @entity0 in the fetal lung and fetal skin and stimulates a systemic inflammatory response that is not generated by fetal blood cells. These data argue for amniotic fluid-exposed tissues that play a key role in driving acute fetal and intrauterine inflammatory responses.

title: Outside-in? @entity0 in very preterm chronically catheterized XXXX fetuses is not driven by cells in the fetal blood.

answer: @entity5


abstract: BACKGROUND: The @entity4 (delivery before 37 weeks gestation) is a major contributor to the global burden of @entity7 and @entity1 . The cause of @entity4 is complex, multifactorial, and likely dependent, at least in part, on the gestational age of the fetus. Intrauterine @entity2 is frequent in preterm deliveries that occur at <32 weeks gestation; understanding how the fetus responds to proinflammatory insult will be an important step towards early @entity4 prevention. However, animal studies of @entity2 and @entity0 in prematurity commonly use older fetuses that possess comparatively mature immune systems. OBJECTIVE: Aiming to characterize acute fetal responses to microbial agonist at a clinically relevant gestation, we used 92-day-old fetuses (62% of term) to develop a chronically catheterized @entity5 model of very preterm pregnancy. We hypothesized that any acute fetal systemic inflammatory responses would be driven by signaling from the tissues exposed to @entity3 lipopolysaccharide that is introduced into the amniotic fluid. STUDY DESIGN: Eighteen ewes that were carrying a single fetus at 92 days of gestation had recovery surgery to place fetal tracheal, jugular, and intraamniotic catheters. Animals were recovered for 24 hours before being administered either intraamniotic @entity3 lipopolysaccharide (n  = 9) or sterile saline solution (n  = 9). Samples were collected for 48 hours before euthanasia and necroscopy. Fetal inflammatory responses were characterized by microarray analysis, quantitative polymerase chain reaction, and enzyme-linked immunosorbent assay. RESULTS: Intraamniotic lipopolysaccharide reached the distal @entity6 within 2 hours. @entity10 increased tracheal fluid @entity9 within 2 hours and generated a robust inflammatory response that was characterized by @entity8 signaling pathway activation and up-regulation of cell proliferation but no increases in inflammatory mediator expression in cord blood RNA. CONCLUSIONS: In very preterm @entity5 fetuses, lipopolysaccharide stimulates @entity0 in the fetal lung and fetal skin and stimulates a systemic inflammatory response that is not generated by fetal blood cells. These data argue for amniotic fluid-exposed tissues that play a key role in driving acute fetal and intrauterine inflammatory responses.

title: Outside-in? XXXX in very preterm chronically catheterized @entity5 fetuses is not driven by cells in the fetal blood.

answer: @entity0


abstract: Twenty-three @entity0 were evaluated from 1-15 (mean 6) years after recovering from an episode of @entity3 -associated associated childhood @entity4 (DA- @entity6 ). All @entity0 had received only conservative treatment; none had been given experimental, anti-coagulant, or immunological therapies. Follow-up studies included morphologic and duplex Doppler sonograms. Doppler sonography was used to determine the resistive index, a measure of renovascular resistance. Histories and physical examinations revealed no abnormalities. Results of laboratory studies, which included calculated glomerular filtration rates, were all within normal limits, except for one @entity0 with minor @entity5 . Renal sonograms showed no significant @entity1 or parenchymal appearance. However, Doppler sonographic examinations revealed that the DA- @entity6 @entity0 demonstrated less of a decrease in renovascular resistance with age than did the control group (p < 0.0002). After recovery, @entity0 treated exclusively with conservative management during an acute episode of DA- @entity6 appeared to have an excellent long-term prognosis. Comparison of our results with those from other studies in which investigational therapies have been used during the acute phase of DA- @entity6 suggests that latent @entity2 which cause long term sequelae may not have been appreciated previously. The clinical significance of the altered renal vascular resistance remains to be delineated.

title: Altered renovascular resistance after spontaneous recovery from XXXX .

answer: @entity4


abstract: BACKGROUND: @entity1 ( @entity1 ) can occur in individuals with low low-density lipoprotein (LDL) @entity2 (LDL-C). We investigated whether detailed measures of LDL subfractions and other lipoproteins can be used to assess @entity1 risk in a population with both low LDL-C and high @entity5 who were randomized to high-intensity statin or placebo. METHODS AND RESULTS: In 11   186 Justification for the Use of @entity6 in Prevention: An Intervention Trial Evaluating @entity7 (JUPITER) @entity0 , we tested whether lipids, apolipoproteins, and ion mobility-measured particle concentrations at baseline and after random allocation to @entity7 20 mg/d or placebo were associated with first @entity1 events (n=307) or @entity1 /all-cause @entity3 (n=522). In placebo-allocated @entity0 , baseline LDL-C was not associated with @entity1 (adjusted hazard ratio [HR] per SD, 1.03; 95% confidence interval [CI], 0.88-1.21). In contrast, associations with @entity1 events were observed for baseline non-high-density lipoprotein (HDL) @entity2 (HR, 1.18; 95% CI, 1.01-1.38), @entity4 (HR, 1.28; 95% CI, 1.11-1.48), and ion mobility-measured non-HDL particles (HR, 1.19; 95% CI, 1.05-1.35) and LDL particles (HR, 1.21; 95% CI, 1.07-1.37). Association with @entity1 events was also observed for several LDL and very-low-density lipoprotein subfractions but not for ion mobility-measured HDL subfractions. In statin-allocated @entity0 , @entity1 events were associated with on-treatment LDL-C, non-HDL @entity2 , and @entity4 ; these were also associated with @entity1 /all-cause @entity3 , as were several LDL and very-low-density lipoprotein subfractions, albeit with a pattern of association that differed from the baseline risk. CONCLUSIONS: In JUPITER, baseline LDL-C was not associated with @entity1 events, in contrast with significant associations for non-HDL @entity2 and atherogenic particles: @entity4 and ion mobility-measured non-HDL particles, LDL particles, and select subfractions of very-low-density lipoprotein particles and LDL particles. During high-intensity statin therapy, on-treatment levels of LDL-C and atherogenic particles were associated with residual risk of @entity1 /all-cause @entity3 . CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00239681.

title: Atherogenic Lipoprotein Subfractions Determined by Ion Mobility and First Cardiovascular Events After Random Allocation to High-Intensity Statin or Placebo: The Justification for the Use of XXXX in Prevention: An Intervention Trial Evaluating @entity7 (JUPITER) Trial.

answer: @entity6


abstract: BACKGROUND: @entity1 ( @entity1 ) can occur in individuals with low low-density lipoprotein (LDL) @entity2 (LDL-C). We investigated whether detailed measures of LDL subfractions and other lipoproteins can be used to assess @entity1 risk in a population with both low LDL-C and high @entity5 who were randomized to high-intensity statin or placebo. METHODS AND RESULTS: In 11   186 Justification for the Use of @entity6 in Prevention: An Intervention Trial Evaluating @entity7 (JUPITER) @entity0 , we tested whether lipids, apolipoproteins, and ion mobility-measured particle concentrations at baseline and after random allocation to @entity7 20 mg/d or placebo were associated with first @entity1 events (n=307) or @entity1 /all-cause @entity3 (n=522). In placebo-allocated @entity0 , baseline LDL-C was not associated with @entity1 (adjusted hazard ratio [HR] per SD, 1.03; 95% confidence interval [CI], 0.88-1.21). In contrast, associations with @entity1 events were observed for baseline non-high-density lipoprotein (HDL) @entity2 (HR, 1.18; 95% CI, 1.01-1.38), @entity4 (HR, 1.28; 95% CI, 1.11-1.48), and ion mobility-measured non-HDL particles (HR, 1.19; 95% CI, 1.05-1.35) and LDL particles (HR, 1.21; 95% CI, 1.07-1.37). Association with @entity1 events was also observed for several LDL and very-low-density lipoprotein subfractions but not for ion mobility-measured HDL subfractions. In statin-allocated @entity0 , @entity1 events were associated with on-treatment LDL-C, non-HDL @entity2 , and @entity4 ; these were also associated with @entity1 /all-cause @entity3 , as were several LDL and very-low-density lipoprotein subfractions, albeit with a pattern of association that differed from the baseline risk. CONCLUSIONS: In JUPITER, baseline LDL-C was not associated with @entity1 events, in contrast with significant associations for non-HDL @entity2 and atherogenic particles: @entity4 and ion mobility-measured non-HDL particles, LDL particles, and select subfractions of very-low-density lipoprotein particles and LDL particles. During high-intensity statin therapy, on-treatment levels of LDL-C and atherogenic particles were associated with residual risk of @entity1 /all-cause @entity3 . CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00239681.

title: Atherogenic Lipoprotein Subfractions Determined by Ion Mobility and First Cardiovascular Events After Random Allocation to High-Intensity Statin or Placebo: The Justification for the Use of @entity6 in Prevention: An Intervention Trial Evaluating XXXX (JUPITER) Trial.

answer: @entity7


abstract: Sinus node responses to perfusion pressure changes, ischaemia and @entity3 were evaluated in 22 isolated blood-perfused @entity0 atria. Sinus cycle length (SCL) was measured and sinoatrial conduction time (SACT) was estimated using the premature atrial stimulation technique (PAS) and the constant atrial pacing method (CAP). There was a good correlation between the results obtained with both techniques (r = 0.8297) but CAP had less @entity1 action on sinus node @entity7 . Increasing the perfusion pressure from 100 to 200 mmHg did not influence estimated SACT nor SCL. However, a reduction in perfusion pressure (from 100 to 50 mmHg) markedly shortened SCL without significantly decreasing estimated SACT. Lowering temperature from 37 to 25 degrees C caused a linear increase in estimated SACT and SCL. @entity2 induced a @entity6 which was not blocked by @entity4 . Estimated SACT was significantly shorter 1 min after occlusion and longer 3 min after occlusion; this increase was significantly inhibited by @entity5 infusion. Thus, the increase in estimated SACT seen after occlusion might be related to cholinergic activity. However, the @entity6 following a decrease in perfusion pressure might be due to activation of the stretch-receptors while the one seen after reduction in blood flow and @entity2 seems more likely to be a consequence of ischaemia.

title: Sinus node responses to perfusion pressure changes, ischaemia and XXXX in the isolated blood-perfused @entity0 atrium.

answer: @entity3


abstract: Sinus node responses to perfusion pressure changes, ischaemia and @entity3 were evaluated in 22 isolated blood-perfused @entity0 atria. Sinus cycle length (SCL) was measured and sinoatrial conduction time (SACT) was estimated using the premature atrial stimulation technique (PAS) and the constant atrial pacing method (CAP). There was a good correlation between the results obtained with both techniques (r = 0.8297) but CAP had less @entity1 action on sinus node @entity7 . Increasing the perfusion pressure from 100 to 200 mmHg did not influence estimated SACT nor SCL. However, a reduction in perfusion pressure (from 100 to 50 mmHg) markedly shortened SCL without significantly decreasing estimated SACT. Lowering temperature from 37 to 25 degrees C caused a linear increase in estimated SACT and SCL. @entity2 induced a @entity6 which was not blocked by @entity4 . Estimated SACT was significantly shorter 1 min after occlusion and longer 3 min after occlusion; this increase was significantly inhibited by @entity5 infusion. Thus, the increase in estimated SACT seen after occlusion might be related to cholinergic activity. However, the @entity6 following a decrease in perfusion pressure might be due to activation of the stretch-receptors while the one seen after reduction in blood flow and @entity2 seems more likely to be a consequence of ischaemia.

title: Sinus node responses to perfusion pressure changes, ischaemia and @entity3 in the isolated blood-perfused XXXX atrium.

answer: @entity0


abstract: OBJECTIVE: To report the increasing frequency with which temporal anteroinferior @entity6 is a cause of adult @entity4 , to illustrate the clinical and imaging characteristics of this condition, and to report its surgical treatment in a series of 23 adult @entity0 . METHODS: @entity1 @entity0 diagnosed with temporal anteroinferior @entity6 from January 2006 to December 2013 in a national @entity1 reference center were included in this noninterventional study. RESULTS: Twenty-three @entity1 @entity0 (14 female, mean age 43.8 years) were diagnosed with temporal anteroinferior @entity6 in our institute. Thirteen @entity0 had >= 2 encephaloceles; 7 cases presented bilaterally. The estimated frequency of this condition was 0.3% among MRI examinations performed due to newly diagnosed @entity1 (n = 6) and 1.9% among drug-resistant @entity0 referred to our center (n = 17). Nine @entity0 with local @entity6 disconnection (n = 4) or anterior temporal lobectomy and amygdalohippocampectomy (n = 5) have become @entity2 -free (Engel 1) for a mean 2.8 years (range 3 months-6.2 years) of follow-up. Three @entity0 with local @entity6 disconnection were almost @entity2 -free or exhibited worthwhile improvement. Histologically, all 12 surgical @entity0 had @entity7 at the base of the @entity6 ; some had cortical laminar disorganization (n = 5) or mild @entity3 (n = 1). CONCLUSIONS: The possibility of a temporal @entity6 should be considered when interpreting MRI examinations of @entity0 with medically intractable @entity5 . These @entity0 can significantly benefit from @entity1 surgery, even in cases with bilateral encephaloceles.

title: Temporal anteroinferior @entity6 : An underrecognized etiology of XXXX ?

answer: @entity4


abstract: OBJECTIVE: To report the increasing frequency with which temporal anteroinferior @entity6 is a cause of adult @entity4 , to illustrate the clinical and imaging characteristics of this condition, and to report its surgical treatment in a series of 23 adult @entity0 . METHODS: @entity1 @entity0 diagnosed with temporal anteroinferior @entity6 from January 2006 to December 2013 in a national @entity1 reference center were included in this noninterventional study. RESULTS: Twenty-three @entity1 @entity0 (14 female, mean age 43.8 years) were diagnosed with temporal anteroinferior @entity6 in our institute. Thirteen @entity0 had >= 2 encephaloceles; 7 cases presented bilaterally. The estimated frequency of this condition was 0.3% among MRI examinations performed due to newly diagnosed @entity1 (n = 6) and 1.9% among drug-resistant @entity0 referred to our center (n = 17). Nine @entity0 with local @entity6 disconnection (n = 4) or anterior temporal lobectomy and amygdalohippocampectomy (n = 5) have become @entity2 -free (Engel 1) for a mean 2.8 years (range 3 months-6.2 years) of follow-up. Three @entity0 with local @entity6 disconnection were almost @entity2 -free or exhibited worthwhile improvement. Histologically, all 12 surgical @entity0 had @entity7 at the base of the @entity6 ; some had cortical laminar disorganization (n = 5) or mild @entity3 (n = 1). CONCLUSIONS: The possibility of a temporal @entity6 should be considered when interpreting MRI examinations of @entity0 with medically intractable @entity5 . These @entity0 can significantly benefit from @entity1 surgery, even in cases with bilateral encephaloceles.

title: Temporal anteroinferior XXXX : An underrecognized etiology of @entity4 ?

answer: @entity6


abstract: AIM: The benefit of preoperative chemotherapy is evaluated in order to clarify the relationship of @entity1 site with hepatic vessels for hepatectomy. @entity1 location in relation to intrahepatic vessels is critical in the decision to operate, but the argument for this concept remains insufficient. Currently, the response rate is evaluated by the decrease in size or number of @entity1 but not by hepatic resection range. @entity0 AND METHODS: We evaluated 32 @entity0 who underwent hepatectomy after chemotherapy for liver metastases from @entity2 (CLM). @entity1 diameter was defined by contrast computed tomographic imaging before both chemotherapy and surgery. The targeted vessels were those in the main Glisson capsule and hepatic vein and were indicated to change in the resected area by their treatment. RESULTS: @entity1 size decreased, increased or remained unchanged in 62 (68.9%), 27 (30.0%) and one (1.1%) @entity1 , respectively. Out of the 29 @entity1 , reduced resection volume was achieved in 12 (37.9%), and the difference in volume was 17.4  4.15 ml. A significant positive correlation was found between @entity1 shrinkage rate and final distance from the attached vessels (p=0.017), and a shrinkage rate of 63.6  12.4% was necessary for a @entity1 to be separated from an attached vessel. The final distance was significantly positively correlated with @entity1 shrinkage speed (p=0.0027), and a shrinkage speed of 0.64  0.12%/day was expected to enable a a @entity1 to be separated from its attached vessel. CONCLUSION: Chemotherapy, especially by favorable combination with molecular targeting agents, even for resectable CLM appears to be acceptable and may lead to increased performance of radical surgical resection.

title: Preoperative Chemotherapy Can Change the Surgical Procedure for Hepatectomy in @entity0 with Liver Metastasis of XXXX .

answer: @entity2


abstract: AIM: The benefit of preoperative chemotherapy is evaluated in order to clarify the relationship of @entity1 site with hepatic vessels for hepatectomy. @entity1 location in relation to intrahepatic vessels is critical in the decision to operate, but the argument for this concept remains insufficient. Currently, the response rate is evaluated by the decrease in size or number of @entity1 but not by hepatic resection range. @entity0 AND METHODS: We evaluated 32 @entity0 who underwent hepatectomy after chemotherapy for liver metastases from @entity2 (CLM). @entity1 diameter was defined by contrast computed tomographic imaging before both chemotherapy and surgery. The targeted vessels were those in the main Glisson capsule and hepatic vein and were indicated to change in the resected area by their treatment. RESULTS: @entity1 size decreased, increased or remained unchanged in 62 (68.9%), 27 (30.0%) and one (1.1%) @entity1 , respectively. Out of the 29 @entity1 , reduced resection volume was achieved in 12 (37.9%), and the difference in volume was 17.4  4.15 ml. A significant positive correlation was found between @entity1 shrinkage rate and final distance from the attached vessels (p=0.017), and a shrinkage rate of 63.6  12.4% was necessary for a @entity1 to be separated from an attached vessel. The final distance was significantly positively correlated with @entity1 shrinkage speed (p=0.0027), and a shrinkage speed of 0.64  0.12%/day was expected to enable a a @entity1 to be separated from its attached vessel. CONCLUSION: Chemotherapy, especially by favorable combination with molecular targeting agents, even for resectable CLM appears to be acceptable and may lead to increased performance of radical surgical resection.

title: Preoperative Chemotherapy Can Change the Surgical Procedure for Hepatectomy in XXXX with Liver Metastasis of @entity2 .

answer: @entity0


abstract: OBJECTIVES: to extend up to year 2013 the follow-up for mortality of a cohort of workers in a @entity6 and @entity5 plating plant, where an @entity1 was already identified. DESIGN: 10 years after the first study about @entity2 mortality in a cohort of workers involved in the @entity6 thin-layer plating, published in 2006, we updated the evaluation of the mortality of a cohort of workers employed in the same @entity6 thin-layer plating factory with at least 6 months of work between 1968 and 1994.The mortality rates are compared with those of the Italian and Veneto Region (Northern Italy) populations. The dose-response relationship between work duration and @entity1 is assessed by adjusted Poisson regression. SETTING AND @entity0 : 127 unskilled or skilled workers involved in the production process. RESULTS: in the updated follow-up, 35 @entity3 occurred among the subjects under study: 19 for @entity2 (of which 11 for @entity1 and 3 for @entity4 ). A marked excess of mortality due to @entity1 is observed. In addition, the new follow-up shows a significant excess of @entity4 mortality. @entity1 mortality is positively associated with work duration and the risk increases by 13%(95%CI 1-26) for each additional year of work. CONCLUSIONS: the extension of follow-up confirms that this cohort expresses an increased mortality from @entity2 , due to a marked @entity4 . The effect of smoking has only a secondary effect in the @entity2 onset expressed by this cohort. The risk of @entity1 increased with work duration and thus with occupational exposure to @entity6 and @entity5 .

title: [Confirmation of an excess of XXXX mortality in a cohort of workers of a @entity6 thin-layer plating].

answer: @entity2


abstract: OBJECTIVES: to extend up to year 2013 the follow-up for mortality of a cohort of workers in a @entity6 and @entity5 plating plant, where an @entity1 was already identified. DESIGN: 10 years after the first study about @entity2 mortality in a cohort of workers involved in the @entity6 thin-layer plating, published in 2006, we updated the evaluation of the mortality of a cohort of workers employed in the same @entity6 thin-layer plating factory with at least 6 months of work between 1968 and 1994.The mortality rates are compared with those of the Italian and Veneto Region (Northern Italy) populations. The dose-response relationship between work duration and @entity1 is assessed by adjusted Poisson regression. SETTING AND @entity0 : 127 unskilled or skilled workers involved in the production process. RESULTS: in the updated follow-up, 35 @entity3 occurred among the subjects under study: 19 for @entity2 (of which 11 for @entity1 and 3 for @entity4 ). A marked excess of mortality due to @entity1 is observed. In addition, the new follow-up shows a significant excess of @entity4 mortality. @entity1 mortality is positively associated with work duration and the risk increases by 13%(95%CI 1-26) for each additional year of work. CONCLUSIONS: the extension of follow-up confirms that this cohort expresses an increased mortality from @entity2 , due to a marked @entity4 . The effect of smoking has only a secondary effect in the @entity2 onset expressed by this cohort. The risk of @entity1 increased with work duration and thus with occupational exposure to @entity6 and @entity5 .

title: [Confirmation of an excess of @entity2 mortality in a cohort of workers of a XXXX thin-layer plating].

answer: @entity6


abstract: AIM: Neuroinflammatory response triggered by the stimulation of matrix metalloproteinases plays a pivotal role in the development of @entity8 phenotype. MMPs stimulate inflammatory cytokines release along with mitochondrial deficits that ultimately lead to @entity5 and precipitate @entity8 symptoms. The aim of the present study was to explore the neuropsychopharmacotherapeutic efficacy of @entity10 in the experimental paradigm of @entity1 . MATERIALS AND METHODS: 1M @entity11 (4 l) was infused over 10min into the anterior portion of the caudoputamen to induce @entity2 in @entity0 . @entity10 (50, 100 and 200mg/kg) was administered per orally starting from 2nd day of surgery and continued up to 28th day. @entity0 were tested for various neurobehavioural paradigms like social interaction, stereotypy, locomotor activity, @entity3 , novelty, @entity4 , @entity9 as well as for repetitive and pervasive behavior. In addition, biochemical tests for oxidative stress, mitochondrial complexes, @entity6 and @entity12 were also carried out. KEY FINDINGS: Intracerebroventricular injection of @entity11 produced neurological, sensory, behavioral, biochemical and molecular deficits which were assessed as endophenotype of @entity1 . Regular treatment with @entity10 for four weeks significantly and dose dependently restored neurological, behavioral, biochemical and molecular changes associated with @entity8 phenotype in @entity0 . SIGNIFICANCE: The major finding of the study is that @entity10 restored the core and associated symptoms of @entity8 phenotype by suppressing oxidative-nitrosative stress, @entity7 , @entity6 and @entity12 in @entity13 -induced @entity8 in @entity0 . Therefore, @entity10 can be developed as a potential neuropsychopharmacotherapeutic adjunct for @entity1 ( @entity1 ).

title: Neuropsychopharmacotherapeutic efficacy of @entity10 in experimental paradigm of XXXX .

answer: @entity1


abstract: AIM: Neuroinflammatory response triggered by the stimulation of matrix metalloproteinases plays a pivotal role in the development of @entity8 phenotype. MMPs stimulate inflammatory cytokines release along with mitochondrial deficits that ultimately lead to @entity5 and precipitate @entity8 symptoms. The aim of the present study was to explore the neuropsychopharmacotherapeutic efficacy of @entity10 in the experimental paradigm of @entity1 . MATERIALS AND METHODS: 1M @entity11 (4 l) was infused over 10min into the anterior portion of the caudoputamen to induce @entity2 in @entity0 . @entity10 (50, 100 and 200mg/kg) was administered per orally starting from 2nd day of surgery and continued up to 28th day. @entity0 were tested for various neurobehavioural paradigms like social interaction, stereotypy, locomotor activity, @entity3 , novelty, @entity4 , @entity9 as well as for repetitive and pervasive behavior. In addition, biochemical tests for oxidative stress, mitochondrial complexes, @entity6 and @entity12 were also carried out. KEY FINDINGS: Intracerebroventricular injection of @entity11 produced neurological, sensory, behavioral, biochemical and molecular deficits which were assessed as endophenotype of @entity1 . Regular treatment with @entity10 for four weeks significantly and dose dependently restored neurological, behavioral, biochemical and molecular changes associated with @entity8 phenotype in @entity0 . SIGNIFICANCE: The major finding of the study is that @entity10 restored the core and associated symptoms of @entity8 phenotype by suppressing oxidative-nitrosative stress, @entity7 , @entity6 and @entity12 in @entity13 -induced @entity8 in @entity0 . Therefore, @entity10 can be developed as a potential neuropsychopharmacotherapeutic adjunct for @entity1 ( @entity1 ).

title: Neuropsychopharmacotherapeutic efficacy of XXXX in experimental paradigm of @entity1 .

answer: @entity10


abstract: PURPOSE: A pharmacokinetic (PK) model is available for describing the time course of the concentrations of @entity0 ( @entity1 or MTXGlu1) and its active polyglutamated metabolites (MTXGlu2-5) in red blood cells (RBCs). In this study, we aimed to simplify the @entity1 PK model and to optimise the blood sampling schedules for use in future studies. METHODS: A proper lumping technique was used to simplify the original @entity1 RBC PK model. The sum of predicted RBC MTXGlu3-5 concentrations in both the simplified and original models was compared. The sampling schedules for MTXGlu3-5 or all @entity1 polyglutamates in RBCs were optimised using the Population OPTimal design (POPT) software. RESULTS: The @entity1 RBC PK model was simplified into a three-state model. The maximum of the absolute value of relative difference in the sum of predicted RBC MTXGlu3-5 concentrations over time was 6.3  %. A five blood sample design was identified for estimating parameters of the simplified model. CONCLUSIONS: This study illustrates the application of model simplification processes to an existing model for @entity1 RBC PK. The same techniques illustrated in our study may be adopted by other studies with similar interest.

title: Simplification of a pharmacokinetic model for red blood cell XXXX disposition.

answer: @entity0


abstract: We have cloned and characterized the 5'-flanking region of the gene encoding @entity0 squalene synthase. We report here the promoter activity of successively 5'-truncated sections of a 1 kilobase of this region by fusing it to the coding region of a luciferase reporter gene. DNA segments of 200 base pairs (bp) 5' to the transcription start site, as determined by primer extension analysis, show a strong promoter effect on the expression of the luciferase chimeric gene and a high response to the presence of @entity4 when transiently transfected into the @entity0 @entity1 cell line HepG2 or to the hamster-derived CHO-K1 cells. An approximately 50-fold induction of luciferase activity, in the absence of @entity4 , was observed in transiently transfected HepG2 cells for fusion constructs containing sections of 200, 459, and 934 bp of the putative @entity0 squalene synthase promoter. Loss of promoter activity and response to @entity4 was localized to a 69-bp section located 131 @entity3 5' to the transcription start site. Sequence analysis of this region showed that it contained a @entity6 regulatory element 1 (SRE-1) previously identified in other @entity6 regulated genes (Smith, J. R., Osborne, T. F., Brown, M. S., Goldstein, J. L., and Gil, G. (1988). J. Biol. Chem. 263, 18480-18487) and two potential NF-1 binding sites. Additional CCAAT box, SRE-1 element, and two @entity5 sites were identified 3' to this section. Sequences within this 69-bp DNA, including the SRE-1 cis-acting element, show strong binding to the purified nuclear transcription factor @entity2 (Tonzonoz, P., Kim, J. B., Graves, R. A., and Spiegelman B. M. (1993) Mol. Cell Biol. 13, 4753-4759) by mobility shift assay and footprinting analyses.

title: Molecular cloning and functional analysis of the promoter of the XXXX squalene synthase gene.

answer: @entity0


abstract: DNA fingerprint patterns of 156 @entity3 isolates (26 @entity2 @entity0 , 46 non- @entity2 @entity0 , and 40 environmental sources) from both varieties (126 @entity3 . neoformans and 30 @entity4 isolates) and from seven countries were analyzed by using the DNA probe UT-4p. Nine and twelve distinct DNA fingerprint patterns were observed for isolates of the @entity3 . neoformans and var. gattii, respectively. No pattern was unique to @entity2 @entity0 , non- @entity2 @entity0 , or the environment. Pattern II was observed more often in non- @entity2 @entity0 (8 of 23) than in @entity2 @entity0 (0 of 25). Pattern V was the most prevalent pattern (42 of 82) in clinical and environmental isolates. Isolates from three @entity2 @entity0 in Burundi and Zaire exhibited patterns identical to each other but different from those of isolates collected from their houses (i.e., dust of floors, walls, etc.) or a nearby pigeon coop. DNA fingerprint stability was determined for 53 isolates from nine non- @entity2 @entity0 at different time intervals during 5 to 128 weeks of antifungal therapy. For eight @entity0 , the fingerprint pattern was stable while the ninth may have had a @entity1 . Pattern II was observed in 4 of 9 @entity0 , which is similar to 4 of 14 in other non- @entity2 @entity0 as reported here. In spite of the extensive pattern heterogeneity among 15 @entity4 isolates in Australia, the patterns observed in seven California isolates were quite different from those in Australia. Among isolates of @entity4 , one fingerprint pattern (designated b) was observed in several countries of the Far East. The fingerprint patterns of two of three environmental isolates from Eucalyptus camaldulensis trees in Australia were identical to those of 2 of the 12 clinical isolates from the country.

title: Diversity of DNA fingerprints in XXXX .

answer: @entity3


abstract: Theory-based nursing practice requires a systematically developed, integrated body of information to deal effectively with the complexities of the @entity0 condition. This philosophical research is founded on a complementary knowledge model, valuing diverse views. The burden therefore is on uncovering connections between perspectives. A method is proposed and tested for mapping pluralistic knowledge in @entity1 . Underlying the method development is the premise that all knowledge can be represented as different combinations of ontology (views of the @entity0 ) and epistemology (nature and aims of science). Based on a review of over 300 references, six major themes (comprised of 20 conceptual categories) are uncovered in the nursing literature. Analysis of the map reveals the influence of trends as well as areas of minimal development (e.g. holism). A key advantage of mapping is the opportunity to know the data in a large substantive area and to begin to identify potential linkages for cumulation. Fatigue, @entity2 , symptom management, day-to-day living with illness, and social support are identified as promising areas to begin building a mid-range theory of @entity1 . Developing a cumulative knowledge base narrows the gap between theory and practice.

title: Mapping knowledge in XXXX .

answer: @entity1


abstract: The type II interleukin-1 receptor ( @entity1 ) is a newly described 60-68 kDa protein expressed on monocytes, neutrophils, and lymphocytes. It is hypothesized that a 45 kDa soluble form of the @entity1 attenuates the proinflammatory effects of IL-1 by preventing its binding to the type I IL-1 receptor. However, very little information exists regarding the detection of soluble @entity1 . Specifically, there are no reports to date characterizing @entity1 detection by enzyme-linked immunoassay in the presence of @entity0 or characterizing @entity0 detection in the presence of @entity1 . This study addresses the detection and quantitation of @entity1 and @entity0 by a number of sandwich ELISA formats and characterizes the sensitivity of detection in the presence of competitive cytokines. We generated two distinct @entity1 sandwich ELISAs that can detect receptor down to a level of 50 pg/ml. One, M22/R2, detects only unbound @entity1 and the other, M2/R2, detects both bound and unbound @entity1 . In this context, a 4:1 molar ratio of @entity0 to @entity1 interferes with the @entity1 detection by the M22/R2 but not the M2/R2 ELISA. Conversely, @entity1 at physiologically relevant concentrations interferes with the detection of @entity0 by three distinct @entity0 ELISA formats. Taken together, these studies suggest that when measuring samples that may contain both @entity0 and @entity1 , careful attention must be given to assay specificity.

title: Detection of soluble type II receptor in the presence of its natural ligand XXXX . Quantification by sandwich ELISA.

answer: @entity0


abstract: Fifty four male @entity0 were divided into 3 main groups. Control group (6 @entity0 ), @entity1 infected group (24 @entity0 ) and @entity8 (CC14) treated group (24 @entity0 ). The last two groups were further subdivided into (4) subgroups (6 @entity0 /each). One of them served as a control while the other 3 subgroups received (0.75, 1.25 _ 2.5 mg/100g B.W.) of @entity7 respectively. CC14 treated @entity0 were severely live 2 damaged than those infected by @entity2 . @entity7 made the liver functions deteriorate. Schistosomiasis did not affect kidney functions while @entity5 _ @entity4 were elevated in CC14 treated group. @entity7 led to more elevation of both. Histological studies of liver treated by CC14 revealed @entity3 , granular cytoplasm and cellular infiltration while schistosomiasis produced the classic granulomatous reaction. @entity7 treatment led to distortion of hepatic cell arrangement as well as marked cellular infiltration and congestion. On the other hand, kidney treated with CC14 showed cellular infiltration around glomeruli, @entity7 caused marked congestion and cellular infiltration. @entity1 infection did not produce any histological changes. All recorded changes could be attributed to the toxic effect of @entity7 , inhibition of @entity6 and weakness of the immunological cells of the liver.

title: Studies on the effect of acute doses of XXXX ( @entity6 inhibitor) during induced liver failure.

answer: @entity7


abstract: Fifty four male @entity0 were divided into 3 main groups. Control group (6 @entity0 ), @entity1 infected group (24 @entity0 ) and @entity8 (CC14) treated group (24 @entity0 ). The last two groups were further subdivided into (4) subgroups (6 @entity0 /each). One of them served as a control while the other 3 subgroups received (0.75, 1.25 _ 2.5 mg/100g B.W.) of @entity7 respectively. CC14 treated @entity0 were severely live 2 damaged than those infected by @entity2 . @entity7 made the liver functions deteriorate. Schistosomiasis did not affect kidney functions while @entity5 _ @entity4 were elevated in CC14 treated group. @entity7 led to more elevation of both. Histological studies of liver treated by CC14 revealed @entity3 , granular cytoplasm and cellular infiltration while schistosomiasis produced the classic granulomatous reaction. @entity7 treatment led to distortion of hepatic cell arrangement as well as marked cellular infiltration and congestion. On the other hand, kidney treated with CC14 showed cellular infiltration around glomeruli, @entity7 caused marked congestion and cellular infiltration. @entity1 infection did not produce any histological changes. All recorded changes could be attributed to the toxic effect of @entity7 , inhibition of @entity6 and weakness of the immunological cells of the liver.

title: Studies on the effect of acute doses of @entity7 ( XXXX inhibitor) during induced liver failure.

answer: @entity6


abstract: The @entity9 ( @entity9 ) model of @entity2 in the @entity3 produces @entity7 and @entity7 in the sciatic distribution of one hindlimb. We previously described the pathology of the affected nerves at the light microscopic and electron microscopic levels and in this report quantify the morphological changes of the nerves. This analysis gives new insights into the pathophysiology and @entity5 -related mechanisms in this model of @entity0 @entity2 . We observed that total @entity6 increased up to fourfold due to an initial massive increase in @entity1 and, later, endoneurial cells. Intact myelinated nerve fibers were reduced from 75% of @entity6 to 29.7% on day 1 and to a minimum of less than 0.5% on day 14 when @entity1 had resolved. The few surviving myelinated fibers were in the small to medium size range. Fiber size histograms revealed an increase in fiber size early on, corresponding to fiber swelling, and the later loss of large as well as small myelinated fibers. Unmyelinated nerve fibers dropped from 19.36/1,000 microns 2 to 6.08/1,000 microns 2 on day 5, and increased from there on. Sprouts were first visible on light micrographs on day 7, occupying 6.8% of @entity6 , while regenerating fibers that were undergoing myelination reached 42.6% of @entity6 by day 42. Macrophage numbers were maximal on day 14 and were still increased on day 42. These data support the hypothesis that the pathogenesis of the extended @entity7 following chronic @entity4 is temporally linked with @entity8 and macrophage activation.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Quantitative neuropathology of a focal @entity4 causing XXXX .

answer: @entity7


abstract: The @entity9 ( @entity9 ) model of @entity2 in the @entity3 produces @entity7 and @entity7 in the sciatic distribution of one hindlimb. We previously described the pathology of the affected nerves at the light microscopic and electron microscopic levels and in this report quantify the morphological changes of the nerves. This analysis gives new insights into the pathophysiology and @entity5 -related mechanisms in this model of @entity0 @entity2 . We observed that total @entity6 increased up to fourfold due to an initial massive increase in @entity1 and, later, endoneurial cells. Intact myelinated nerve fibers were reduced from 75% of @entity6 to 29.7% on day 1 and to a minimum of less than 0.5% on day 14 when @entity1 had resolved. The few surviving myelinated fibers were in the small to medium size range. Fiber size histograms revealed an increase in fiber size early on, corresponding to fiber swelling, and the later loss of large as well as small myelinated fibers. Unmyelinated nerve fibers dropped from 19.36/1,000 microns 2 to 6.08/1,000 microns 2 on day 5, and increased from there on. Sprouts were first visible on light micrographs on day 7, occupying 6.8% of @entity6 , while regenerating fibers that were undergoing myelination reached 42.6% of @entity6 by day 42. Macrophage numbers were maximal on day 14 and were still increased on day 42. These data support the hypothesis that the pathogenesis of the extended @entity7 following chronic @entity4 is temporally linked with @entity8 and macrophage activation.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Quantitative neuropathology of a focal XXXX causing @entity7 .

answer: @entity4


abstract: 1. Electroolfactorgram (EOG) recordings were made from different regions of the @entity0 olfactory epithelium to test for spatial distribution of odor responses. 2. The EOG recordings showed spatial distribution of the odor responses in the olfactory epithelium. While some odorants ( @entity4 , @entity6 , and @entity5 ) were more effective in evoking responses in the dorsal recess near the septum, other odorants (including @entity1 , @entity3 , @entity7 , and @entity2 ) were more effective in the lateral recesses among the turbinate bones. These differences were seen as statistically significant odorant-by-position interactions in analysis of variance. 3. Comparisons of recordings along the anteroposterior dimension of the epithelium produced smaller differences between the odor responses. These were not significant for 3-mm distances, but were statistically significant for 5- to 6-mm distances along the dorsomedial epithelium. 4. The latencies were significantly longer in the lateral recesses than in the medial region. This probably reflects a more tortuous air path along the turbinate bones to the lateral recesses. 5. The olfactory receptor cells were activated by antidromic stimulation via the nerve layer of the olfactory bulb. The population spikes evoked from the olfactory receptor cells could be suppressed by prior stimulation with odorants that evoked strong EOG responses. This collision of the antidromic action potentials with the odor-evoked action potentials indicates that the same population of receptor cells was activated in both cases. 6. The flow rate and duration of the artificial sniff were varied systematically in some experiments. The differential distribution of response sizes was present at all flow rates and sniff durations. Some odors (e.g., @entity4 and @entity6 ) produced increased responses in the epithelium of the lateral recesses when flow rates or sniff durations were high. We suggest that these changes may reflect the sorptive properties of the nasal membranes on these odors. The responses to other odors (e.g., @entity2 or @entity1 ) were not greatly affected by flow rate or sniff duration. 7. Taken with existing anatomic data, the results indicate that the primary olfactory neurons that project axons to glomeruli in different parts of the olfactory bulb are responsive to different odors. The latency differences between responses at medial and lateral sites are large enough to be physiologically significant in the generation of the patterned responses of olfactory bulb neurons.

title: Regional distribution of XXXX electroolfactogram.

answer: @entity0


abstract: A retrospective study of external lumbar subarachnoid drainage in 16 pediatric @entity0 with severe @entity2 is presented. All @entity0 had Glasgow @entity3 Scale scores of 8 or lower at 6 hours postinjury and were initially treated with ventriculostomy. Five @entity0 required surgical evacuation of focal mass lesions. All @entity0 manifested high intracranial pressures (ICPs) refractory to aggressive therapy, including hyperventilation, @entity4 , @entity5 , and in some cases, artificially induced barbiturate @entity3 . After lumbar drainage was instituted, 14 @entity0 had an abrupt and lasting decrease in @entity1 , obviating the need for continued medical management of @entity1 . In no @entity0 did transtentorial or cerebellar herniation occur as a result of lumbar drainage. It was also noted retrospectively that the @entity0 in this study had discernible basilar cisterns on computerized tomography scans. Fourteen @entity0 survived; eight made good recoveries, three are functional with disability, and three have severe disabilities. Two @entity0 died, most likely from uncontrolled @entity1 before the lumbar drain was placed. It is concluded that controlled external lumbar subarachnoid drainage is a useful treatment for pediatric @entity0 with severe @entity2 when aggressive medical therapy and ventricular cerebrospinal fluid evacuation have failed to control high @entity1 . Selected @entity0 with @entity1 , which may be a function of posttraumatic cerebrospinal fluid circulation disruption and/or @entity6 , can be treated with this modality, which accesses the cisternal spaces untapped by ventriculostomy.

title: Controlled lumbar drainage in pediatric XXXX .

answer: @entity2


abstract: AIMS AND OBJECTIVES: The aim of this study was to evaluate the effects of music therapy on @entity1 , @entity3 and physiological reactions to emotional and physical distress in @entity0 undergoing spinal surgery. BACKGROUND: Surgery-related @entity1 and @entity2 are the greatest concern of surgical @entity0 , especially for those undergoing major procedures. DESIGN: A quasi-experimental study design was conducted in a medical centre in Taiwan from April-July 2006. METHODS: Sixty @entity0 were recruited. The study group listened to selected music from the evening before surgery to the second day after surgery. The control group did not listen to music. @entity0 ' levels of @entity1 and @entity2 were measured with visual analogue scales (VAS). Physiological measures, including heart rate, blood pressure and 24-hour urinalysis, were performed. RESULTS: The average age of the 60 @entity0 was 62  18 (SD 18  76) years. The mean VAS score for degree of @entity1 in the study group was 0  8-2  0, compared with 2  1-5  1 in the control group. The mean VAS score for degree of @entity2 in the study group was 1  7-3  0, compared with 4  4-6  0 in the control group. The differences between the two groups in VAS scores for both @entity1 (p = 0  018-0  001) and @entity2 (p = 0  001) were statistically significant. One hour after surgery, the mean blood pressure was significantly lower in the study group than in the control group (p   =   0  014), but no significant differences were found between the two groups in urine @entity4 (p   =   0  145-0  495), @entity5 (p = 0  228-0  626) or epinephrine values (p = 0  074-0  619). CONCLUSIONS: Music therapy has some positive effects on levels of @entity1 and @entity2 in @entity0 undergoing spinal surgery. RELEVANCE TO CLINICAL PRACTICE: Complementary music therapy can alleviate @entity2 and @entity1 in @entity0 before and after spinal surgery.

title: Music therapy for XXXX receiving spine surgery.

answer: @entity0


abstract: BACKGROUND: Because the incidence of childhood @entity8 peaks between 2 and 4 years of age, the risk factors may exert their influence during the prenatal and/or the neonatal periods. Results of previous studies of perinatal risk factors have been contradictory, perhaps because most studies either have been hospital based or have been restricted to limited geographical areas. PURPOSE: A nationwide case-control study was carried out to identify maternal and perinatal risk factors for this disease. METHODS: The case-control study was nested in cohorts defined by all live births in Sweden recorded in the nationwide Medical Birth Register. Since 1973, this register has routinely collected information on all hospital births in regard to maternal demographic data, reproductive history, pregnancy, delivery, and the neonatal period. From the Swedish National @entity1 Register, 613 case subjects were identified in successive birth cohorts from 1973 through 1989. Five control subjects per case subject were randomly selected from the pool of @entity0 matched by sex and month and year of birth. Conditional logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for potential risk factors and to estimate their effects after adjustment for possible confounders. RESULTS: Risk of childhood @entity7 at all ages increased with @entity5 (OR = 20.0; 95% CI = 4.2-94.2), @entity2 (OR = 4.4; 95% CI = 1.6-12.1), use of supplementary @entity3 (OR = 2.3; 95% CI = 1.5-3.6), postpartum @entity6 (OR = 1.8; 95% CI = 1.2-2.6), birth weight of more than 4500 g (OR = 1.7; 95% CI = 1.1-2.7), and @entity4 disease during pregnancy (OR = 1.4; 95% CI = 1.0-1.9). @entity5 affected risk mostly in @entity0 younger than 5 years, whereas other factors affected those @entity0 5 years old or older. Being one of a multiple birth also increased risk among older @entity0 (OR = 2.5; 95% CI = 1.0-6.0). Use of supplementary @entity3 may act as a causal intermediate (surrogate) for postpartum @entity6 and its causes, as would high birth weight for its causes. CONCLUSIONS: Several maternal and perinatal risk factors were found to be associated with childhood @entity7 , but they showed age-specific differences. Overall, only a few risk factors were identified, and these accounted for a small proportion of cases. We concluded that most risk factors for childhood @entity7 remain unidentified in very young @entity0 .

title: Prenatal and neonatal risk factors for childhood XXXX .

answer: @entity7


abstract: Among the five immediate-early regulatory proteins of @entity3 , only ICP0 is capable of activating all kinetic classes of viral genes. Consistent with its broad transactivating activity, ICP0 plays a major role in enhancing the reactivation of HSV from latency both in vivo and in vitro. Although not essential for viral replication, ICP0 confers a significant growth advantage on the virus, especially at low multiplicities of @entity1 . In this report we describe the expression of a novel activity by the @entity2 cell line U2OS that can substitute functionally for ICP0. Compared with Vero cells, both @entity0 cells and cells of the ICP0-expressing line 0-28 significantly enhanced the plating efficiency of an ICP0 null mutant, 7134. In contrast, the plating efficiencies of the wild-type virus in all three cell types were similar. Single-step growth experiments demonstrated that the yield of 7134 in @entity0 cells was severalfold higher than that in 0-28 cells and about 100-fold higher than that in Vero cells. In order to identify the viral genes whose expression is enhanced by the activity in @entity0 cells, levels of expression of selected viral proteins in extracts of Vero and @entity0 cells were compared by Western blot (immunoblot) analysis following low-multiplicity @entity1 . At a multiplicity of 0.1 PFU per cell, the levels of expression of the immediate-early protein ICP4 and the early protein gD in 7134-infected @entity0 cells were significantly higher than those in 7134-infected Vero cells. When infections were carried out at a multiplicity of 1 PFU per cell, however, no major differences in the levels of expression of these proteins in @entity0 and Vero cells were observed. Cycloheximide reversal experiments demonstrated that the cellular activity expressed in @entity0 cells that promotes high-level expression of ICP4 is not synthesized de novo but appears to exist as a preformed protein(s). To confirm this observation and to determine whether, like immediate-early genes, early, delayed-early, and late viral genes are also responsive to the cellular activity, transient-expression assays were performed. The results of these tests demonstrated that basal levels of expression from immediate-early, early, and delayed-early promoters, but not that from a late promoter, were significantly higher in @entity0 cells than in Vero cells and that this enhancement occurred in the absence of viral proteins.(ABSTRACT TRUNCATED AT 400 WORDS)

title: An activity specified by the XXXX line U2OS can substitute functionally for ICP0, a major regulatory protein of herpes simplex virus type 1.

answer: @entity2


abstract: UNASSIGNED: The aim of this study was to test the hypothesis in the literature that torque resistance of @entity2 is the difference between the independent contributions of stretched and shortened muscles. The hypothesis was tested using muscle-specific stretch-shortening (MSSS) EMG ratio in this study. Nineteen @entity0 with @entity1 ( @entity1 ) and 18 healthy subjects (the mean age comparable to that of @entity0 ) participated in this study. The EMG activity was measured in the four muscles involved in wrist joint movement, i.e. flexor carpi radialis, flexor carpi ulnaris, extensor carpi radialis and extensor carpi ulnaris. The passive flexion-extension movement with a range of   30    was applied at wrist joint. Root mean squared (RMS) mean was calculated from the envelope of the EMG for each of stretching and shortening phases. MSSS EMG ratio was defined as the ratio of RMS EMG of stretching phase and RMS EMG of shortening phase of a single muscle, and it was calculated for each muscle. MSSS EMG ratios were smaller than one in all muscles. These results indicate that all wrist muscles generate greater mean EMG during shortening than during stretching. Therefore, the torque resistance of @entity2 cannot be explained as the simple summation of independent antagonistic torque pair.

title: Comparison of EMG during passive stretching and shortening phases of each muscle for the investigation of XXXX .

answer: @entity2


abstract: We examined patterns of airway response of thirty nine @entity1 @entity0 who had positive responses on allergen inhalation tests. Six types of inhaled allergens were used: house dust mite, animal, pollen, plant, mold, and others. Three patterns of responses were found: isolated immediate @entity2 response (IAR), immediate and late response (Dual), and isolated late @entity2 response (LAR). No relationship was found between the pattern of response and pulmonary function, airway sensitivity, IgE RIST titers, numbers of eosinophils, or concentration of inhaled antigens. Animal antigens tended to cause a dual response, and molds did only rarely. Ten of 39 challenged @entity0 had an isolated LAR, half of which were caused by mold antigen inhalation. RAST scores were lower in isolated LAR than in other responses. Changes in the number and proportion of peripheral leukocytes during the challenge tests were also studied. Total leukocyte count had increased significantly in the isolated LAR group by 24 hours after the inhalation. These results suggest that the pattern of airway response after inhalation depended in part on the type of inhaled antigen, and that non-IgE mediated immune reactions have some role in the isolated LAR.

title: [Factors influencing patterns of airway response after allergen challenge in @entity0 with XXXX ].

answer: @entity1


abstract: We examined patterns of airway response of thirty nine @entity1 @entity0 who had positive responses on allergen inhalation tests. Six types of inhaled allergens were used: house dust mite, animal, pollen, plant, mold, and others. Three patterns of responses were found: isolated immediate @entity2 response (IAR), immediate and late response (Dual), and isolated late @entity2 response (LAR). No relationship was found between the pattern of response and pulmonary function, airway sensitivity, IgE RIST titers, numbers of eosinophils, or concentration of inhaled antigens. Animal antigens tended to cause a dual response, and molds did only rarely. Ten of 39 challenged @entity0 had an isolated LAR, half of which were caused by mold antigen inhalation. RAST scores were lower in isolated LAR than in other responses. Changes in the number and proportion of peripheral leukocytes during the challenge tests were also studied. Total leukocyte count had increased significantly in the isolated LAR group by 24 hours after the inhalation. These results suggest that the pattern of airway response after inhalation depended in part on the type of inhaled antigen, and that non-IgE mediated immune reactions have some role in the isolated LAR.

title: [Factors influencing patterns of airway response after allergen challenge in XXXX with @entity1 ].

answer: @entity0


abstract: We studied the detailed profiles of blood flow in the right and left pulmonary arteries using 20 MHz pulsed Doppler ultrasound equipment in a lamb model. Fourteen @entity2 aged four to six weeks were selected. In six @entity2 , @entity3 was injected parenterally to create @entity0 (PH group). Eight other @entity2 served as unaltered controls (control group). The blood flow velocities were sampled in 1mm increments along the anterior-posterior axis of the branch arteries. The maximum velocity of the forward flow in the @entity1 was higher than that in the right pulmonary artery in the control group (71.7 +/- 15.9 cm/s vs 60.2 +/- 13.5; p < 0.05). The fastest backward flow was located at the posterior position of the vessel in the right pulmonary artery in the control group (71.7 +/- 15.9 cm/s vs 60.2 +/- 13.5; p < 0.05). The fastest backward flow was located at the posterior position of the vessel in the right pulmonary artery in the control group. No significant bias in location was shown in the @entity1 . Using indices of P90, acceleration time, P90*AcT, the velocity waveforms in the PH group were compared with those in the control group. In the @entity1 , every index in the control group showed a significantly greater value that in the PH group. On the other hand, no significant differences were found between either group in the right pulmonary artery.

title: Blood flow velocity profiles in pulmonary branch arteries in XXXX .

answer: @entity2


abstract: BACKGROUND: Deterioration associated with aging in the erect posture and balance to change the location of the center increased the rate of fall in older age is one of the reasons. Loss of muscle strength is one of the major factors affecting the posture. In this prospective, randomized and controlled study, it was aimed to investigate the effectiveness of strengthening postural muscles through electrostimulation or by applying biofeedback exercises with static posturography in @entity0 aged 60 years and over with @entity1 . METHODS: @entity0 aged between 60-80 years, who applied to Istanbul Faculty of Medicine Physical Medicine and Rehabilitation Department outpatient clinic and had been diagnosed with @entity1 using the Timed Up and Go (TUG) test, were included. 250 @entity0 were screened, from them 67 @entity0 were enrolled and 57 of them completed the study. @entity0 were randomized to three groups. The @entity0 in @entity3 ( @entity3 ) group (n:18) participated in a 15-minute exercise with Tetrax   which consisted of 15 minutes exercise session 3 times weekly for 4 weeks. The @entity0 in EG group (n:19) received an electrostimulation program of postural muscles of 40 minutes per session 3 times weekly for 4 weeks. @entity0 in the control group (n:20) did 6-week balance exercises which were performed by other groups as well. 48 out of 57 @entity0 attended the 6th-month control. As determinants of balance status Timed Up and Go Test (TUG), Berg Balance Scale (BBS) and Fall Index measured by Tetrax   were calculated at baseline, 1-month and 6-month follw up assesments. The @entity0 's quality of life was assesed by Turkish version of World Health Organisation Quality of Life Questionnaire in Older Adults (WHOQOL-OLD.TR) at baseline and 6-month follow up assesments. RESULTS: TUG values in both EG and @entity3 decreased significantly between baseline assesment and 1-month (mean differences for @entity3 : -4,00    1,309 and EG -2,588    1,839 p= 0,002 for the each of groups) and baseline assesment and 6-month (mean differences for @entity3 : -2,933   1,223 and EG -2,058    1,477 p= 0,003 for the each of groups). A significant increase was determined in BBS values between baseline and 1-month (mean differences for @entity3 : 4.000    2,360 and EG: 3,529    2,672 p= 0,031 for the each of groups). Fall Index (FI) measured by Tetrax   decreased between baseline assesment and 1-month (p= 0,185), and 6-month (p= 0,086) respectively, also between 1-month and 6-month follow up assesments (p= 0,627), but all of them were not significant changes. In all three groups the quality of life (p= 0,951) improved. Exercises conducted with Tetrax   were more effective than electrostimulation of postural muscles in increasing TUG values and decreasing BBS values. CONCLUSIONS: Even though applying electrostimulation to postural muscles affected @entity0 positively compared to pre-treatment, exercises performed with Tetrax   were more effective than the electrostimulation protocol to postural muscles in @entity2 and this well-being continued even in the 6th month.

title: Investigating the effectiveness of postural muscle electrostimulation and static posturography feedback exercises in elders with XXXX .

answer: @entity1