abstract: Since the description of the association of HLA-B8 antigen with @entity3 , it has been confirmed by many authors. The incidence of HLA-B8 antigen is higher in adults and @entity0 when it is compared to apparently healthy controls. Some authors found a reduction on the incidence of HLA-B7 antigen and others suggested that a higher incidence of HLA-B12 antigen in @entity0 HLA-B8 antigen negative, is associated with @entity3 . We studied 19 unrelated @entity0 with @entity3 and 64 controls. Their ages range from 18 months to 18 years old, onset of the disease was during childhood. We determined twelve antigens of the @entity1 locus and thirteen antigens of the @entity2 locus. We used the NIH Microlymphocytotoxicity Technique. The degree of association was computed by the relative risk and the results were statistically evaluated by the X2. The statistically significant increase in frequency was shown only for HLA-A29 The results did not show neither the higher incidence for HLA-B8 found by other authors, nor the higher incidence for HLA-B12; however HLA-B7 was not detected in our @entity0 . The final decision on the association of HLA-A29 antigen with @entity3 in our population will require examination of a broader panel of probands.

title: [ XXXX and HLA in a hospital population of Uruguay].

answer: @entity3


abstract: BACKGROUND: @entity1 is a common condition, and a common complaint leading @entity0 to @entity3 ( @entity3 ). There have been a number of studies of the effect of environmental factors on @entity1 , such as weather and air pollutants. METHODS: This retrospective cohort study included data on daily @entity3 visits with a chief complaint of @entity1 in Soroka University Medical Center (SUMC) during 2002-2012. Data on weather and air pollutants were obtained from monitor station in Be'er-Sheva. To estimate the short-term effects of air pollution and temperature on number of @entity5 visits, we applied generalized linear mixed models (GLMM). RESULTS: A total of 22,021 @entity3 visits were included in the analysis. An increase in 5    in temperature was associated with an increase in @entity3 visits, relative risk (RR)   =   1.042, (95% CI 1.009; 1.076). RR for @entity1 was associated with an increase in 10 units of @entity7 ( @entity6 ), RR   =   1.110 (95% CI 1.057; 1.167), with a higher effect for older @entity0 . DISCUSSION: The current findings give evidence of an association between air pollution, weather and @entity3 visits for @entity1 , especially for @entity6 . Short-term increases in air pollution exposure may trigger @entity1 by @entity2 , increasing @entity4 or altering endothelial function.

title: Ambient air pollution, weather and daily emergency department visits for XXXX .

answer: @entity1


abstract: This report describes a phase II Eastern Cooperative Oncology Group (ECOG) study of high-dose lymphoblastoid interferon ( @entity4 -n1) in 39 @entity0 with measurable, advanced @entity3 . The original treatment plan was 30 X 10(6) units/m2 (30 mU) of @entity4 -n1 im daily X 10 days; treatments were repeated every 21 days. This dose and schedule proved intolerable, with none of seven @entity0 able to complete greater than 10 days of therapy because of fever, lassitude, @entity2 , and myelosuppression. @entity0 were subsequently treated with the following regimen: 3 mU/m2 on Day 1; 5 mU/m2 on Day 2; 10 mU/m2 on Day 3; and 20 mU/m2 on Days 4-10. Thirty-three new @entity0 received this regimen and two @entity0 received this schedule after having received 30 mU/m2. Using this second regimen, 30% of the @entity0 were able to complete two cycles of treatment without dose reduction or interruption. Five @entity0 (13%) had partial response (ECOG criteria) of measurable @entity1 . Median time to response was 140 days. Responses were documented in lung metastases in four @entity0 and in a pelvic soft tissue mass in the fifth. Response rates and survival times are similar to those seen in prior ECOG phase II trials in advanced @entity3 . Eight of 39 @entity0 are still alive greater than 2 years after beginning therapy. Only two of these @entity0 had had an objective response, however. Such prolonged survival is more frequent than has been seen in previous ECOG studies. The relative contribution of @entity0 selection and interferon therapy to this survival is uncertain.

title: High-dose lymphoblastoid interferon in advanced XXXX : an Eastern Cooperative Oncology Group Study.

answer: @entity3


abstract: BACKGROUND AND PURPOSE: In-room cone-beam CT (CBCT) imaging and adaptive treatment strategies are promising methods to decrease target volumes and to spare organs at risk. The aim of this work was to analyze the inter-observer contouring uncertainties of target volumes and organs at risks (oars) in localized @entity1 radiotherapy using CBCT images. Furthermore, CBCT contouring was benchmarked against other image modalities (CT, MR) and the influence of subjective image quality perception on inter-observer variability was assessed. METHODS AND MATERIALS: Eight @entity1 @entity0 were selected. Seven radiation oncologists contoured target volumes and oars on CT, MRI and CBCT. Volumes, coefficient of variation (COV), conformity index (cigen), and coordinates of center-of-mass (COM) were calculated for each @entity0 and image modality. Reliability analysis was performed for the support of the reported findings. Subjective perception of image quality was assessed via a ten-scored visual analog scale (VAS). RESULTS: The median volume for prostate was larger on CT compared to MRI and CBCT images. The inter-observer variation for prostate was larger on CBCT (CIgen=0.57  0.09, 0.61 reliability) compared to CT (CIgen=0.72  0.07, 0.83 reliability) and MRI (CIgen=0.66  0.12, 0.87 reliability). On all image modalities values of the intra-observer reliability coefficient (0.97 for CT, 0.99 for MR and 0.94 for CBCT) indicated high reproducibility of results. For all @entity0 the root mean square (RMS) of the inter-observer standard deviation (  ) of the COM was largest on CBCT with   (x)=0.4 mm,   (y)=1.1 mm, and   (z)=1.7 mm. The concordance in delineating OARs was much stronger than for target volumes, with average CIgen>0.70 for rectum and CIgen>0.80 for bladder. Positive correlations between CIgen and VAS score of the image quality were observed for the prostate, seminal vesicles and rectum. CONCLUSIONS: Inter-observer variability for target volume delineation in @entity1 is larger for CBCT-based contouring compared to CT and MRI. This factor of influence needs to be considered when defining safety margins for CBCT-based Adaptive Radiotherapy (ART).

title: Feasibility of CBCT-based target and normal structure delineation in XXXX radiotherapy: multi-observer and image multi-modality study.

answer: @entity1


abstract: One hundred and fifty four @entity0 with a displaced subcapital @entity2 of the neck of the femur were treated by primary replacement with a cemented Thompson prosthesis. The average age of the @entity0 was 74.8 years and most had evidence of @entity1 . Two @entity0 had the procedure performed on both sides. The operation was carried out through an antero-lateral approach. Mobilisation began on the day following operation and @entity0 were encouraged to walk on the fifth day. No dislocations were seen. The important early complications were not at the site of operation but were secondary to associated diseases. Following early unrestricted weight bearing 111 @entity0 (71.1%) were discharged within three weeks of the operation. Twenty three (14.7%) died during the six weeks following the procedure. At follow up between one and seven years after operation (mean 3.9 years), fifty @entity0 had died, but of the 63 survivors contacted 78% had a good to excellent result whilst only 5% were classified as poor.

title: The Thompson prosthesis in the treatment of subcapital XXXX of the neck of the femur.

answer: @entity2


abstract: Intussusception is a very rare cause of @entity2 in neonates. It is of extremely rare occurrence among premature neonates. We present a case of 11-day-old @entity4 who presented with abdominal distension, intolerance to feeds, @entity1 , significant bilious aspirate and bleeding per rectum. The initial diagnosis of @entity3 ( @entity3 ) led to a delay in the diagnosis. On exploratory laparotomy, it turned out to be a case of ileo-colic intussusception with @entity5 as a lead point. This site of intussusception (ileo-colic) and presence of a lead point among @entity4 is of exceedingly rare occurrence and very few such cases have been reported. In this article, the published work about clinical features and management on intussusceptions in premature neonates has been reviewed. The authors intend to highlight the difficulty in distinguishing the @entity3 and intussusception. Subtle clinical and radiological features which can help in differentiating the two conditions have been emphasized. This can avoid the delay in diagnosis and management which can prove critical. High index of suspicion with timely intervention is the key for optimizing outcome. A diagnosis of intussusception should always be considered in any preterm @entity0 with suspected @entity3 .

title: Intussusception in a XXXX : A rare and often misdiagnosed clinical entity.

answer: @entity4


abstract: Complex neurologic phenotypes are inherently difficult to diagnose. Whole-exome sequencing (WES) is a new tool in the neurologist's diagnostic armamentarium. Whole-exome sequencing can be applied to investigate the "diagnostic odyssey" cases. These cases involve @entity0 with @entity2 that likely have a genetic etiology but have failed to be diagnosed by clinical evaluation and targeted gene testing. We describe such a case, a 22-year-old @entity0 who had mild @entity3 and episodes of @entity4 that affected his whole body. He underwent numerous multidisciplinary and multicentric evaluations throughout his life that failed to establish a clear diagnosis. Following his visit to Mayo Clinic in Jacksonville, Florida, WES was applied for genetic determination of the unknown disorder in the proband and his biological parents and sister. Additional clinical evaluation, magnetic resonance neuroimaging, electromyography, and electroencephalography of the proband were performed to verify the phenotype after the WES results were available. To our knowledge, this is the first report of the application of WES to facilitate the diagnosis of @entity5 . This case illustrates that WES supported by clinical data is a useful and time-saving tool in the evaluation of @entity0 with @entity1 .

title: Whole-exome sequencing as a diagnostic tool in a family with XXXX .

answer: @entity5


abstract: OBJECTIVES: The accurate noninvasive assessment of preload in @entity2 ( @entity2 ) @entity0 remains elusive. Point-of-care ultrasound (US) imaging, particularly evaluation of the inferior vena cava (IVC), has been shown to be qualitatively helpful. Doppler and tissue Doppler are now routinely available on @entity2 US equipment, but few studies have looked at the correlation of dynamic changes in these parameters in a controlled model of @entity4 . Our objective was to examine the correlation of Doppler parameters to simulated @entity3 in healthy subjects using a lower-body negative pressure (LBNP) model and to compare these measurements to commonly used IVC measurements of preload. METHODS: Twelve paid volunteers with no known @entity1 between the ages of 23 and 31 years old (mean    SD = 25.5    2.5 years old) were recruited. @entity4 was simulated using graduated LBNP levels with measurements taken at 0, -30, and -60 mm Hg and lower pressures as tolerated. Vital signs were monitored in all @entity0 . US measurements recorded at each negative pressure level included IVC maximum (IVC(max)) and minimum (IVC(min)) dimensions; early (E) and late (A) transmitral filling velocities using pulsed-wave spectral Doppler; and early (E') and late (A') tissue Doppler velocities at the septal ((sep)) and lateral ((lat)) mitral annulus, using pulsed-wave tissue Doppler. RESULTS: Lower-body negative pressure correlated significantly and positively within subjects for all US parameters except for the A filling wave. E'(lat) and E'(sep) showed the strongest correlation with R   values of 0.749 (95% confidence interval [CI] = 0.577 to 0.854) and 0.738 (95% CI = 0.579 to 0.875) respectively, followed by A'(sep) 0.674 (95% CI = 0.416 to 0.845), IVC(max) 0.638 (95% CI = 0.425 to 0.806), A'(lat) 0.547 (95% CI = 0.280 to 0.802), IVC(min) 0.512 (95% CI = 0.192 to 0.777), and E 0.478 (95% CI = 0.187 to 0.762). Ratios correlated only moderately with LBNP level, including E/ E'(lat) R   of 0.430 (95% CI = 0.131 to 0.706), E/ E'(sep) 0.416 (95% CI = 0.183 to 0.686), and IVC collapsibility index (IVC(CI)) 0.201 (95% CI = 0.003 to 0.681). Vital signs, including heart rate and blood pressure, did not vary significantly with LBNP levels. CONCLUSIONS: In this pilot study of healthy subjects, tissue Doppler assessment of early diastolic filling correlated most strongly with simulated @entity4 .

title: Tissue Doppler of early mitral filling correlates with simulated XXXX in healthy subjects.

answer: @entity3


abstract: Purpose. To evaluate the relationship between the expression of orbital tissue mRNA for @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , and @entity5 / @entity5 and the severity of @entity4 ( @entity4 ). Material and Methods. Orbital tissue was obtained from 26 @entity0 with @entity4 , with mild (n = 6) or severe @entity4 (n = 20), and 7 healthy controls. The expression of mRNA of @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , @entity5 / @entity9 was measured by RT-PCR. TCR and CD3 were evaluated by immunohistochemistry. Results. Higher mRNA for @entity1 (relative expression: 1.4) and @entity5 (1.27) and lower expression of @entity7 (0.61) were found in the @entity4 tissues versus controls. In severe @entity4 as compared to mild @entity4 higher mRNA expression for @entity1 (1.35) and @entity5 (1.4) and lower expression for @entity7 (0.78), @entity2 (0.62), and @entity9 (0.56) were found. A positive correlation was found between @entity1 mRNA and CD3 infiltration (R = 0.796, P = 0.0000001). Conclusions. The enhanced @entity1 mRNA expression in @entity4 samples may suggest the dysfunction of @entity1 cells in the severe @entity4 . The diminished mRNA expression of @entity7 in severe @entity4 may indicate inadequate T regulatory function. The enhanced mRNA expression of @entity5 in severe @entity4 and negative correlation to @entity3 mRNA may suggest their role in the active and inactive @entity4 .

title: Disturbances of Modulating Molecules ( @entity1 , XXXX / @entity2 /B7, and @entity5 / @entity9 ) mRNA Expressions in the Orbital Tissue from @entity0 with Severe Graves' Ophthalmopathy.

answer: @entity7


abstract: Purpose. To evaluate the relationship between the expression of orbital tissue mRNA for @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , and @entity5 / @entity5 and the severity of @entity4 ( @entity4 ). Material and Methods. Orbital tissue was obtained from 26 @entity0 with @entity4 , with mild (n = 6) or severe @entity4 (n = 20), and 7 healthy controls. The expression of mRNA of @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , @entity5 / @entity9 was measured by RT-PCR. TCR and CD3 were evaluated by immunohistochemistry. Results. Higher mRNA for @entity1 (relative expression: 1.4) and @entity5 (1.27) and lower expression of @entity7 (0.61) were found in the @entity4 tissues versus controls. In severe @entity4 as compared to mild @entity4 higher mRNA expression for @entity1 (1.35) and @entity5 (1.4) and lower expression for @entity7 (0.78), @entity2 (0.62), and @entity9 (0.56) were found. A positive correlation was found between @entity1 mRNA and CD3 infiltration (R = 0.796, P = 0.0000001). Conclusions. The enhanced @entity1 mRNA expression in @entity4 samples may suggest the dysfunction of @entity1 cells in the severe @entity4 . The diminished mRNA expression of @entity7 in severe @entity4 may indicate inadequate T regulatory function. The enhanced mRNA expression of @entity5 in severe @entity4 and negative correlation to @entity3 mRNA may suggest their role in the active and inactive @entity4 .

title: Disturbances of Modulating Molecules ( @entity1 , @entity7 / XXXX /B7, and @entity5 / @entity9 ) mRNA Expressions in the Orbital Tissue from @entity0 with Severe Graves' Ophthalmopathy.

answer: @entity2


abstract: Purpose. To evaluate the relationship between the expression of orbital tissue mRNA for @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , and @entity5 / @entity5 and the severity of @entity4 ( @entity4 ). Material and Methods. Orbital tissue was obtained from 26 @entity0 with @entity4 , with mild (n = 6) or severe @entity4 (n = 20), and 7 healthy controls. The expression of mRNA of @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , @entity5 / @entity9 was measured by RT-PCR. TCR and CD3 were evaluated by immunohistochemistry. Results. Higher mRNA for @entity1 (relative expression: 1.4) and @entity5 (1.27) and lower expression of @entity7 (0.61) were found in the @entity4 tissues versus controls. In severe @entity4 as compared to mild @entity4 higher mRNA expression for @entity1 (1.35) and @entity5 (1.4) and lower expression for @entity7 (0.78), @entity2 (0.62), and @entity9 (0.56) were found. A positive correlation was found between @entity1 mRNA and CD3 infiltration (R = 0.796, P = 0.0000001). Conclusions. The enhanced @entity1 mRNA expression in @entity4 samples may suggest the dysfunction of @entity1 cells in the severe @entity4 . The diminished mRNA expression of @entity7 in severe @entity4 may indicate inadequate T regulatory function. The enhanced mRNA expression of @entity5 in severe @entity4 and negative correlation to @entity3 mRNA may suggest their role in the active and inactive @entity4 .

title: Disturbances of Modulating Molecules ( XXXX , @entity7 / @entity2 /B7, and @entity5 / @entity9 ) mRNA Expressions in the Orbital Tissue from @entity0 with Severe Graves' Ophthalmopathy.

answer: @entity1


abstract: Purpose. To evaluate the relationship between the expression of orbital tissue mRNA for @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , and @entity5 / @entity5 and the severity of @entity4 ( @entity4 ). Material and Methods. Orbital tissue was obtained from 26 @entity0 with @entity4 , with mild (n = 6) or severe @entity4 (n = 20), and 7 healthy controls. The expression of mRNA of @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , @entity5 / @entity9 was measured by RT-PCR. TCR and CD3 were evaluated by immunohistochemistry. Results. Higher mRNA for @entity1 (relative expression: 1.4) and @entity5 (1.27) and lower expression of @entity7 (0.61) were found in the @entity4 tissues versus controls. In severe @entity4 as compared to mild @entity4 higher mRNA expression for @entity1 (1.35) and @entity5 (1.4) and lower expression for @entity7 (0.78), @entity2 (0.62), and @entity9 (0.56) were found. A positive correlation was found between @entity1 mRNA and CD3 infiltration (R = 0.796, P = 0.0000001). Conclusions. The enhanced @entity1 mRNA expression in @entity4 samples may suggest the dysfunction of @entity1 cells in the severe @entity4 . The diminished mRNA expression of @entity7 in severe @entity4 may indicate inadequate T regulatory function. The enhanced mRNA expression of @entity5 in severe @entity4 and negative correlation to @entity3 mRNA may suggest their role in the active and inactive @entity4 .

title: Disturbances of Modulating Molecules ( @entity1 , @entity7 / @entity2 /B7, and XXXX / @entity9 ) mRNA Expressions in the Orbital Tissue from @entity0 with Severe Graves' Ophthalmopathy.

answer: @entity5


abstract: Purpose. To evaluate the relationship between the expression of orbital tissue mRNA for @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , and @entity5 / @entity5 and the severity of @entity4 ( @entity4 ). Material and Methods. Orbital tissue was obtained from 26 @entity0 with @entity4 , with mild (n = 6) or severe @entity4 (n = 20), and 7 healthy controls. The expression of mRNA of @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , @entity5 / @entity9 was measured by RT-PCR. TCR and CD3 were evaluated by immunohistochemistry. Results. Higher mRNA for @entity1 (relative expression: 1.4) and @entity5 (1.27) and lower expression of @entity7 (0.61) were found in the @entity4 tissues versus controls. In severe @entity4 as compared to mild @entity4 higher mRNA expression for @entity1 (1.35) and @entity5 (1.4) and lower expression for @entity7 (0.78), @entity2 (0.62), and @entity9 (0.56) were found. A positive correlation was found between @entity1 mRNA and CD3 infiltration (R = 0.796, P = 0.0000001). Conclusions. The enhanced @entity1 mRNA expression in @entity4 samples may suggest the dysfunction of @entity1 cells in the severe @entity4 . The diminished mRNA expression of @entity7 in severe @entity4 may indicate inadequate T regulatory function. The enhanced mRNA expression of @entity5 in severe @entity4 and negative correlation to @entity3 mRNA may suggest their role in the active and inactive @entity4 .

title: Disturbances of Modulating Molecules ( @entity1 , @entity7 / @entity2 /B7, and @entity5 / XXXX ) mRNA Expressions in the Orbital Tissue from @entity0 with Severe Graves' Ophthalmopathy.

answer: @entity9


abstract: Purpose. To evaluate the relationship between the expression of orbital tissue mRNA for @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , and @entity5 / @entity5 and the severity of @entity4 ( @entity4 ). Material and Methods. Orbital tissue was obtained from 26 @entity0 with @entity4 , with mild (n = 6) or severe @entity4 (n = 20), and 7 healthy controls. The expression of mRNA of @entity1 , @entity7 / @entity2 / @entity8 / @entity6 , @entity5 / @entity9 was measured by RT-PCR. TCR and CD3 were evaluated by immunohistochemistry. Results. Higher mRNA for @entity1 (relative expression: 1.4) and @entity5 (1.27) and lower expression of @entity7 (0.61) were found in the @entity4 tissues versus controls. In severe @entity4 as compared to mild @entity4 higher mRNA expression for @entity1 (1.35) and @entity5 (1.4) and lower expression for @entity7 (0.78), @entity2 (0.62), and @entity9 (0.56) were found. A positive correlation was found between @entity1 mRNA and CD3 infiltration (R = 0.796, P = 0.0000001). Conclusions. The enhanced @entity1 mRNA expression in @entity4 samples may suggest the dysfunction of @entity1 cells in the severe @entity4 . The diminished mRNA expression of @entity7 in severe @entity4 may indicate inadequate T regulatory function. The enhanced mRNA expression of @entity5 in severe @entity4 and negative correlation to @entity3 mRNA may suggest their role in the active and inactive @entity4 .

title: Disturbances of Modulating Molecules ( @entity1 , @entity7 / @entity2 /B7, and @entity5 / @entity9 ) mRNA Expressions in the Orbital Tissue from XXXX with Severe Graves' Ophthalmopathy.

answer: @entity0


abstract: @entity8 -201 myocardial imaging was performed in 21 @entity0 with @entity7 ( @entity7 ). Thirteen @entity0 were studied before operation, eight @entity0 after Mustard operation and five @entity0 after Rastelli operation. Five @entity0 were studied sequentially before and after the surgery. Each image was compared with hemodynamic and angiographic findings in order to assess the usefulness of this method. In the 13 @entity0 with preoperative @entity7 , it was possible to differentiate @entity7 with the intact ventricular septum from @entity7 with associated anomalies such as @entity6 or @entity5 , and also @entity7 with @entity1 or @entity3 from @entity7 without them by evaluating the degree of @entity8 uptake in the free wall of the pulmonary ventricle (anatomical left ventricle). The degree of @entity8 uptake was well correlated with systolic pressure of the pulmonary ventricle (r = 0.98). In the 13 @entity0 with postoperative @entity7 , it was less correlated with the pulmonary ventricular systolic pressure (r = 0.83). Four cases sequentially studied showed a marked decrease in @entity8 uptake in the pulmonary ventricle 10 to 16 months after Rastelli operation. But the corrected @entity8 uptake ( @entity8 activity/ventricular systolic pressure) was more increased compared with the uptake of the systemic ventricle after the surgery. This was probably related to a decrease of the pressure load to the pulmonary ventricle following the surgery and to the fact that there should be some delay of a decrease of the ventricular mass. An increased lung uptake of @entity8 was noted in the cases of @entity4 after Mustard operation, but the degree of regurgitation was not clearly correlated with the increase of @entity8 uptake in the lung. In five cases after Rastelli operation, one @entity0 showed a high degree of @entity8 uptake of the pulmonary ventricle (anatomical right ventricle), and the conduit valve @entity2 and severe @entity3 were confirmed by cardiac catheterization and angiography. Thus myocardial imaging provides a reliable mean for the qualitative and quantitative assessment of @entity7 before and after operation.

title: [Myocardial imaging in @entity0 with XXXX : comparison between Mustard and Rastelli operations].

answer: @entity7


abstract: @entity8 -201 myocardial imaging was performed in 21 @entity0 with @entity7 ( @entity7 ). Thirteen @entity0 were studied before operation, eight @entity0 after Mustard operation and five @entity0 after Rastelli operation. Five @entity0 were studied sequentially before and after the surgery. Each image was compared with hemodynamic and angiographic findings in order to assess the usefulness of this method. In the 13 @entity0 with preoperative @entity7 , it was possible to differentiate @entity7 with the intact ventricular septum from @entity7 with associated anomalies such as @entity6 or @entity5 , and also @entity7 with @entity1 or @entity3 from @entity7 without them by evaluating the degree of @entity8 uptake in the free wall of the pulmonary ventricle (anatomical left ventricle). The degree of @entity8 uptake was well correlated with systolic pressure of the pulmonary ventricle (r = 0.98). In the 13 @entity0 with postoperative @entity7 , it was less correlated with the pulmonary ventricular systolic pressure (r = 0.83). Four cases sequentially studied showed a marked decrease in @entity8 uptake in the pulmonary ventricle 10 to 16 months after Rastelli operation. But the corrected @entity8 uptake ( @entity8 activity/ventricular systolic pressure) was more increased compared with the uptake of the systemic ventricle after the surgery. This was probably related to a decrease of the pressure load to the pulmonary ventricle following the surgery and to the fact that there should be some delay of a decrease of the ventricular mass. An increased lung uptake of @entity8 was noted in the cases of @entity4 after Mustard operation, but the degree of regurgitation was not clearly correlated with the increase of @entity8 uptake in the lung. In five cases after Rastelli operation, one @entity0 showed a high degree of @entity8 uptake of the pulmonary ventricle (anatomical right ventricle), and the conduit valve @entity2 and severe @entity3 were confirmed by cardiac catheterization and angiography. Thus myocardial imaging provides a reliable mean for the qualitative and quantitative assessment of @entity7 before and after operation.

title: [Myocardial imaging in XXXX with @entity7 : comparison between Mustard and Rastelli operations].

answer: @entity0


abstract: BACKGROUND: Insulin-resistant states, such as @entity3 and @entity1 ( @entity1 ), have been associated with chronic low-grade systemic @entity2 . Elevated levels of @entity4 ( @entity4 ), monocyte chemoattractant protein ( @entity9 ) and @entity6 (hs-CRP), are found in @entity0 with @entity8 . @entity7 ( @entity7 ), a potent vasopressor, seems to regulate also the expression of the above inflammatory mediators acting as proinflammatory cytokine. In this study, we examined the effects of @entity5 , an angiotensin receptror blocker, in the chronic low-grade @entity2 observed in @entity10 2. MATERIALS AND METHODS: Seventeen @entity0 with @entity1 of <5years duration were recruited for the study. @entity0 received 4mg of @entity5 , an angiotensin receptor blocker, for 6months. Blood levels of @entity4 , @entity9 , hs-CRP and other inflammatory indices were measured before and at the end of @entity5 administration. RESULTS: At the end of treatment with @entity5 , @entity4 levels decreased significantly (P<0  05). Serum levels of @entity9 and hs-CRP showed a trend for significant decrease with treatment (P<0  08 and P<0  09, respectively). Statistically significant correlations were found between hs-CRP and @entity9 (r=0  623, P<   0  05), @entity4 and @entity9 (r=0  703, P<0  05) and TRT and @entity9 (r=0  752, P<0  05), before but not at the end of @entity5 administration. CONCLUSIONS: @entity5 could decrease the low-grade @entity2 of type 2 @entity10 as shown by the decrease of inflammatory mediators. Thus, angiotensin receptor blockers could be useful for treating @entity0 with @entity1 not only for their antihypertensive capacity but also for their anti-inflammatory actions.

title: Angiotensin blockade in XXXX @entity0 decreases insulin resistance-associated low-grade @entity2 .

answer: @entity1


abstract: BACKGROUND: Insulin-resistant states, such as @entity3 and @entity1 ( @entity1 ), have been associated with chronic low-grade systemic @entity2 . Elevated levels of @entity4 ( @entity4 ), monocyte chemoattractant protein ( @entity9 ) and @entity6 (hs-CRP), are found in @entity0 with @entity8 . @entity7 ( @entity7 ), a potent vasopressor, seems to regulate also the expression of the above inflammatory mediators acting as proinflammatory cytokine. In this study, we examined the effects of @entity5 , an angiotensin receptror blocker, in the chronic low-grade @entity2 observed in @entity10 2. MATERIALS AND METHODS: Seventeen @entity0 with @entity1 of <5years duration were recruited for the study. @entity0 received 4mg of @entity5 , an angiotensin receptor blocker, for 6months. Blood levels of @entity4 , @entity9 , hs-CRP and other inflammatory indices were measured before and at the end of @entity5 administration. RESULTS: At the end of treatment with @entity5 , @entity4 levels decreased significantly (P<0  05). Serum levels of @entity9 and hs-CRP showed a trend for significant decrease with treatment (P<0  08 and P<0  09, respectively). Statistically significant correlations were found between hs-CRP and @entity9 (r=0  623, P<   0  05), @entity4 and @entity9 (r=0  703, P<0  05) and TRT and @entity9 (r=0  752, P<0  05), before but not at the end of @entity5 administration. CONCLUSIONS: @entity5 could decrease the low-grade @entity2 of type 2 @entity10 as shown by the decrease of inflammatory mediators. Thus, angiotensin receptor blockers could be useful for treating @entity0 with @entity1 not only for their antihypertensive capacity but also for their anti-inflammatory actions.

title: Angiotensin blockade in @entity1 @entity0 decreases insulin resistance-associated low-grade XXXX .

answer: @entity2


abstract: BACKGROUND: Insulin-resistant states, such as @entity3 and @entity1 ( @entity1 ), have been associated with chronic low-grade systemic @entity2 . Elevated levels of @entity4 ( @entity4 ), monocyte chemoattractant protein ( @entity9 ) and @entity6 (hs-CRP), are found in @entity0 with @entity8 . @entity7 ( @entity7 ), a potent vasopressor, seems to regulate also the expression of the above inflammatory mediators acting as proinflammatory cytokine. In this study, we examined the effects of @entity5 , an angiotensin receptror blocker, in the chronic low-grade @entity2 observed in @entity10 2. MATERIALS AND METHODS: Seventeen @entity0 with @entity1 of <5years duration were recruited for the study. @entity0 received 4mg of @entity5 , an angiotensin receptor blocker, for 6months. Blood levels of @entity4 , @entity9 , hs-CRP and other inflammatory indices were measured before and at the end of @entity5 administration. RESULTS: At the end of treatment with @entity5 , @entity4 levels decreased significantly (P<0  05). Serum levels of @entity9 and hs-CRP showed a trend for significant decrease with treatment (P<0  08 and P<0  09, respectively). Statistically significant correlations were found between hs-CRP and @entity9 (r=0  623, P<   0  05), @entity4 and @entity9 (r=0  703, P<0  05) and TRT and @entity9 (r=0  752, P<0  05), before but not at the end of @entity5 administration. CONCLUSIONS: @entity5 could decrease the low-grade @entity2 of type 2 @entity10 as shown by the decrease of inflammatory mediators. Thus, angiotensin receptor blockers could be useful for treating @entity0 with @entity1 not only for their antihypertensive capacity but also for their anti-inflammatory actions.

title: Angiotensin blockade in @entity1 XXXX decreases insulin resistance-associated low-grade @entity2 .

answer: @entity0


abstract: OBJECTIVES: To retrospectively assess the long-term outcome for @entity1 that were presented with collapse, @entity2 or exercise intolerance for which an underlying cause is not identified. METHODS: The clinical records of animals presenting to two practices were assessed. @entity1 which presented for collapse, @entity2 or exercise intolerance at least 6 months previously and did not receive a definitive diagnosis despite investigation were included. Follow-up of these cases was carried out by conducting telephone interviews with the owners. RESULTS: One hundred and fifty-three cases were successfully followed up. Clinical signs had resolved in 64 cases (42%), 35 @entity1 (23%) were continuing to exhibit clinical signs, although 22 of these had improved without medical intervention. In 17 cases (11%), a diagnosis had subsequently been made or treatment was being administered and 37 @entity1 (24%) had died. Of the deaths, 18 (12%) were considered to be related to the original presentation. The overall prevalence of @entity0 and deterioration related to the problems investigated was 16  2% of cases. Death in boxers was significantly more common than in other breeds (36%). CLINICAL SIGNIFICANCE: Death and deterioration are uncommon outcomes for @entity1 other than boxers presenting with collapse, @entity2 and exercise intolerance for which a definitive diagnosis cannot be made.

title: A retrospective study of 153 cases of undiagnosed collapse, XXXX or exercise intolerance: the outcomes.

answer: @entity2


abstract: An 18-year-old @entity0 was evaluated for a chronic productive cough and @entity4 . She was subsequently diagnosed with mediastinal @entity6 ( @entity6 ). A covered @entity5 ( @entity5 ) was implanted to relieve narrowing in for both main bronchi. The @entity6 went into complete remission after six chemotherapy cycles, but atelectasis developed in the left lower lobe 18 months after @entity5 insertion. The left main bronchus was completely occluded by granulation tissue. However, the right main bronchus and intermedius bronchus were patent. Granulation tissue was observed adjacent to the @entity5 . The granulation tissue and the @entity5 were excised, and a @entity3 stent was successfully implanted using a rigid bronchoscope. @entity5 is advantageous owing to its easy implantation, but there are considerable potential complications such as severe reactive granulation, stent @entity1 , and ventilation failure in serious cases. Therefore, @entity5 should be avoided whenever possible in @entity0 with benign airway disease. This case highlights that @entity5 implantation should be avoided even in malignant @entity2 cases if the underlying malignancy is curable.

title: Serious Complications after Self-expandable Metallic Stent Insertion in a XXXX with Malignant Lymphoma.

answer: @entity0


abstract: The effect of inclusion of garlic essential oil (EO) at 33, 66 and 100   g mL(-1), raw garlic (GAR) at 5, 10 and 15 mg mL(-1) and monensin (MON) at 7.5   g mL(-1) of incubation medium on @entity0 ( @entity0 ) was studied with in vitro gas production, ANKOM daisy(II) and conventional in vitro (IVOMD) methods. The material was incubated with @entity1 ruminal fluid and the experimental design was a completely randomized design. Cumulative gas production was recorded at 0, 2, 4, 6, 8, 12, 16, 24, 36, 48, 72 and 96 hours of incubation. Conventional in vitro @entity0 was determined after 48 hours incubation in acid and pepsin solutions. Samples for Daisy(II) @entity0 prepared according to the operating instructions supplied by ANKOM(  ) Tech. Co., Fairport, USA. Compared to @entity0 ( @entity0 ), Daisy(II) and gas production techniques overestimated (P < 0.05) @entity0 . The addition of EO and MON reduced (P < 0.05) the organic matter (OM), neutral detergent fiber (NDF), acid-detergent fiber (ADF) digestion, and gas production volume. The potential of gas production and rate of gas production for EO and MON were the lowest; however, these variables were higher for GAR supplemented groups. It was concluded that raw garlic could be of great interest for its usage as a modulator of ruminal fermentation.

title: In vitro assessment of the digestibility of forage based XXXX diet, supplemented with raw garlic, garlic oil and monensin.

answer: @entity1


abstract: This study is an investigation of the relationship between morphological, neuropsychological, and clinical measurements, all presumably contributing to an expert's diagnosis of @entity2 . Morphological assessment was carried out by linear measurements taken from the photographs of the CT scanners display. The battery of tests comprised instruments able to evaluate performance (WAIS, Benton test, d2 test, Trail Making test) as well as personality (FPI) from a quantitative point of view. For clinical assessment the Assessment Scale for Gerontopsychiatry (AGP) was used. A group of 39 @entity0 suffering from mild to severe @entity3 was studied. The results show strong correlations between some sub-tests of the WAIS and certain CT measurements but fail to show comparable features in using the full scale IQ. The other cognitive tests did not work as well in detecting @entity4 . Surprisingly, the personality inventory (FPI) showed some correlations with @entity4 . A number of correlations between morphological and clinical variables were found as well, consistent with well-known clinical experience. Topographical features will be discussed supporting the view that @entity1 in the progress of @entity2 take the form of distinct patterns.

title: Correlations between psychopathology, psychological test results and computerized tomography changes in XXXX .

answer: @entity2


abstract: Introduction : A prospective study was carried out in Department of Obstretics and Gynaecology in KIMS Hospital Bangalore, India, for a period of 18 mnth from 2005-2008. Sixty cases were selected for this study from @entity0 who were above the age of 40 y and who were presented with a history of abnormal uterine @entity2 (after excluding pregnancy and its complications, @entity0 with local causes of @entity2 , @entity0 with @entity1 cervix and @entity3 ). All @entity0 underwent transvaginal sonography and hysteroscopy. Dilatation and curettage was done in cases with abnormal endometrial findings and sample sent for histopathology examination. Performance of TVS pick up rate in relation to hysteroscopy were analysed by various statistical methods. RESULTS: In the present study, transvaginal ultrasound showed an accuracy of 83.3% in detecting the proliferative phase and 66.67% in detecting the secretory phase. TVS has a sensitivity of 0% for a local lesion (intra-cavitary) of endometrial cavity. TVS was also preferable in case of post-menopausal @entity0 with endometrial thickness less than 4mm. CONCLUSION: Both TVS and hysteroscopy can detect endometrial intracavitary abnormalities with varying accuracies. These can supplement and enhance the accuracy of tissue diagnosis. Thus, the first procedure to which @entity0 with AUB are to be subjected should be TVS followed by hysteroscopy and hysteroscopically directed biopsy, wherever required.

title: Role of transvaginal sonography and diagnostic hysteroscopy in abnormal uterine XXXX .

answer: @entity2


abstract: @entity4 ( @entity4 ) has been considered as a strict contraindication to transurethral resection of the prostate (TURP). In recent years, some studies have shown that holmium laser enucleation of the prostate (HoLEP) has less @entity1 compared to TURP. Thus we have performed HoLEP in @entity0 with @entity2 ( @entity2 ) under continuous @entity4 from September 2009, and herein we report our first nine cases. @entity0 received HoLEP by a single surgeon at our institution. HoLEP was performed successfully in all @entity0 . The mean times to complete enucleation and morcellation were 48.2 and 5.1 minutes, respectively. The mean tissue weight of enucleation was 37 grams. The mean hemoglobin and @entity3 loss after HoLEP were 1.7 g/dl and 1.3 mEq/L, respectively, and the catheterization time was 1.6 days. Blood transfusion, clot retention or transurethral resection syndrome were not observed in any cases. HoLEP has excellent hemostatic properties, and is a safe and effective procedure for @entity0 with symptomatic @entity2 under the condition of continuous @entity4 .

title: [Holmium laser enucleation of the prostate (HoLEP) in XXXX with continuous oral anticoagulation: first reported cases in Japan].

answer: @entity0


abstract: UNASSIGNED: The postcranial evidence for the Australopithecus genus indicates that australopiths were able bipeds; however, the morphology of the forelimbs and particularly that of the shoulder girdle suggests that they were partially adapted to an arboreal lifestyle. The nature of such arboreal adaptations is still unclear, as are the kind of @entity1 in which australopiths might have engaged. In this study we analyzed the shape of the shoulder joint (proximal humerus and glenoid cavity of the scapula) of three australopith specimens: A.L. 288-1 (A. afarensis), @entity2 7 (A. africanus) and Omo 119-73-2718 (Australopithecus sp.) with three-dimensional geometric morphometrics. The morphology of the specimens was compared with that of a wide array of living anthropoid taxa and some additional fossil hominins (the Homo erectus specimen KNM-WT 15000 and the @entity3 specimen Tabun 1). Our results indicate that A.L. 288-1 shows mosaic traits resembling @entity0 and Pongo, whereas the @entity2 7 shoulder is most similar to the arboreal apes and does not present affinities with @entity0 . Omo 119-73-2718 exhibits morphological affinities with the more arboreal and partially suspensory New World monkey Lagothrix. The shoulder of the australopith specimens thus shows a combination of primitive and derived traits (humeral globularity, enhancement of internal and external rotation of the joint), related to use of the arm in overhead positions. The genus Homo specimens show overall affinities with @entity0 at the shoulder, indicating full correspondence of these hominin shoulders with the modern @entity0 morphotype.

title: Like Father, Like Son: Assessment of the Morphological Affinities of A.L. 288-1 (A. afarensis), XXXX 7 (A. africanus) and Omo 119-73-2718 (Australopithecus sp.) through a Three-Dimensional Shape Analysis of the Shoulder Joint.

answer: @entity2


abstract: In addition to classical spinocerebellar pathways, the cerebellum receives information from the spinal cord indirectly via spino-bulbar-cerebellar systems. One of the structures in this pathway is the lateral reticular nucleus (LRt). We performed series of experiments to investigate the organization and neurotransmitter content of spinoreticular tract (SRT) neurons in the lumbar spinal cord that project to the LRt. Three @entity0 received injections of the b subunit of Cholera toxin ( @entity3 ) or Fluorogold (FG) within the left and right LRt. The majority of SRT cells (56-61%) were found within the contralateral medial intermediate gray matter where small numbers (7-10%) of double-labeled cells were also present on both sides of the cord. Six @entity0 received unilateral spinal injections of @entity3 to label spinal projections to the LRt. Injections of FG were made also into the anterior lobe of the cerebellum to label LRt pre-cerebellar neurons. Terminals were found mainly ipsilateral to spinal injection sites within the central and ventrolateral regions of the LRt. Immunocytochemical analysis of SRT terminals revealed that the majority (75%) were contained vesicular @entity2 transporter 2 but a minority (20%) contained the vesicular @entity1 transporter. The inhibitory subpopulation was found to be GABAergic, glycinergic, or contained both transmitters. Inhibitory and excitatory terminals were present within overlapping regions of the nucleus. Most @entity3 terminals contacting LRt pre-cerebellar neurons were excitatory (80%) whereas a minority were inhibitory and most cells (88%) received contacts from both inhibitory and excitatory terminals. This study shows that SRT axons in the LRt have the capacity to exert direct excitatory and inhibitory actions on LRt pre-cerebellar neurons. Thus spinal cord input has the capacity to facilitate or depress the activity of individual LRt cells which in turn adjust activity in the cerebellum to produce coordinated motor behaviors.

title: The spino-bulbar-cerebellar pathway: organization and neurochemical properties of spinal cells that project to the lateral reticular nucleus in the XXXX .

answer: @entity0


abstract: Schema Therapy has shown promising results for @entity3 but there is a limited evidence base for group schema therapy ( @entity4 ) with @entity3 . The aim of this study was to explore the feasibility, acceptability, and preliminary effectiveness of @entity4 in a sample of eight @entity0 with @entity3 (with a predominant diagnosis of @entity3 ) and high levels of comorbidity. Treatment was comprised of 20 sessions which included cognitive, behavioral, and experiential techniques. Specific schema-based strategies were chosen for a diagnostically mixed group of @entity3 clients. Six @entity0 attended until end of treatment and two dropped-out before mid-treatment. All outcome measures showed changes with large effect sizes in @entity3 symptom severity, @entity2 and @entity1 levels between pre-therapy and follow-up. Four @entity0 achieved a loss of @entity3 diagnosis at the end of therapy. By follow-up, five @entity0 had achieved a loss of diagnosis, suggesting that @entity0 derived ongoing benefits from the group even after treatment ended. Six @entity0 no longer met criteria for @entity2 at the end of treatment and this was maintained for all @entity0 at 6-month follow-up. At follow-up, the majority of @entity0 showed clinically significant change on the Global Symptom Index (GSI). For the Schema Mode Inventory (SMI) maladaptive modes, the majority of @entity0 showed improvement at follow-up. At follow-up, 40% of @entity0 showed clinically significant change on the SMI adaptive modes. Qualitative feedback indicates that the group helps to normalize @entity0 ' psychological experiences and difficulties and promotes self-expression and self-disclosure, while reducing inhibition. Preliminary results suggest that short-term @entity4 may benefit those with @entity3 , but generalizability is limited by the small sample size and lack of control group.

title: Short-term group schema therapy for XXXX : a pilot study.

answer: @entity3


abstract: A predictive technique in the management of @entity0 with @entity1 could improve the therapeutic index by allowing better individualization of treatment. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive technique that can provide anatomical and physiological information on the @entity1 and its microenvironment. We studied the effect of chemotherapy ( @entity3 ), anti-angiogenesis therapy ( @entity5 ) and radiotherapy on the kinetics of DCE-MRI parameters in a preclinical model of @entity4 using P846, a new low-diffusible contrast agent. @entity2 underwent DCE-MRI before treatment ( @entity7 ), after 1 week of treatment (MRI2), and after 1 additional week (MRI3). Combined treatment with radiotherapy and @entity5 had a synergistic effect on @entity1 growth. In radiotherapy/ @entity5 -treated @entity2 , a decrease in K(trans) at MRI2 predicted its superior antivascular and antitumor effect at an early time. An increased K(trans) at MRI2, as seen in @entity3 - and @entity3 / @entity5 -treated @entity2 , reflects increased permeability for P846 and might predict a smaller therapeutic effect at this early time. This study shows that the kinetics of DCE-MRI parameters depends on the contrast agent used. P846 appears to be a promising low-diffusible agent to monitor therapeutic effects in this preclinical @entity1 model, but further studies are needed to compare its behavior with @entity6 and macromolecular-weight contrast agents. @entity5 as a radiosensitizer is promising for future clinical trials in @entity0 @entity4 .

title: Noninvasive monitoring of therapy-induced microvascular changes in a XXXX model using dynamic contrast-enhanced magnetic resonance imaging with P846, a new low-diffusible gadolinium-based contrast agent.

answer: @entity4


abstract: BACKGROUND: Blunt @entity6 is a leading cause of @entity2 in @entity1 @entity0 . A reliable test predicting @entity3 would be a novel method. The study objective was to assess the diagnostic accuracy of plasma @entity5 in detection of @entity3 in @entity0 with blunt @entity4 (BAT). MATERIALS AND METHODS: In this observational study, all @entity0 suffering from BAT, referred to our university teaching hospital included. The levels of @entity5 were measured at the time of emergency department admission and 1 h after initial treatment. Demographic data, vital signs, and venous blood gas reports were recorded. Findings of contrast-enhanced abdominopelvic computed tomography scan and laparotomy were assumed as a gold standard for @entity6 . RESULTS: A total of 104 @entity0 was enrolled in the study. 15 @entity0 (14.4%) had @entity3 and the mean plasma @entity5 level in this group was significantly higher than the other @entity0 on admission time (101.73    5.41  g/dL vs. 47.36    26.31  g/dL, P < 0.001). On receiver-operator characteristic curve analysis, in cutoff point of 89  g/dL, the sensitivity, specificity, positive and negative likelihood ratios were 100% (95% confidence interval [CI], 79.6-100), 93.26% (95% CI, 86-96.8), 14.83 (95% CI, 6.84-32.12), and 0, respectively. CONCLUSION: The study findings suggest the measurement of @entity5 level at the time of admission in the @entity0 with BAT would be a useful test predicting @entity3 . Furthermore, decrease in the @entity5 level could be a useful marker for monitoring response to treatment in these @entity0 .

title: Role of plasma @entity5 level in detecting @entity3 following blunt XXXX .

answer: @entity4


abstract: BACKGROUND: Blunt @entity6 is a leading cause of @entity2 in @entity1 @entity0 . A reliable test predicting @entity3 would be a novel method. The study objective was to assess the diagnostic accuracy of plasma @entity5 in detection of @entity3 in @entity0 with blunt @entity4 (BAT). MATERIALS AND METHODS: In this observational study, all @entity0 suffering from BAT, referred to our university teaching hospital included. The levels of @entity5 were measured at the time of emergency department admission and 1 h after initial treatment. Demographic data, vital signs, and venous blood gas reports were recorded. Findings of contrast-enhanced abdominopelvic computed tomography scan and laparotomy were assumed as a gold standard for @entity6 . RESULTS: A total of 104 @entity0 was enrolled in the study. 15 @entity0 (14.4%) had @entity3 and the mean plasma @entity5 level in this group was significantly higher than the other @entity0 on admission time (101.73    5.41  g/dL vs. 47.36    26.31  g/dL, P < 0.001). On receiver-operator characteristic curve analysis, in cutoff point of 89  g/dL, the sensitivity, specificity, positive and negative likelihood ratios were 100% (95% confidence interval [CI], 79.6-100), 93.26% (95% CI, 86-96.8), 14.83 (95% CI, 6.84-32.12), and 0, respectively. CONCLUSION: The study findings suggest the measurement of @entity5 level at the time of admission in the @entity0 with BAT would be a useful test predicting @entity3 . Furthermore, decrease in the @entity5 level could be a useful marker for monitoring response to treatment in these @entity0 .

title: Role of plasma @entity5 level in detecting XXXX following blunt @entity4 .

answer: @entity3


abstract: BACKGROUND: Blunt @entity6 is a leading cause of @entity2 in @entity1 @entity0 . A reliable test predicting @entity3 would be a novel method. The study objective was to assess the diagnostic accuracy of plasma @entity5 in detection of @entity3 in @entity0 with blunt @entity4 (BAT). MATERIALS AND METHODS: In this observational study, all @entity0 suffering from BAT, referred to our university teaching hospital included. The levels of @entity5 were measured at the time of emergency department admission and 1 h after initial treatment. Demographic data, vital signs, and venous blood gas reports were recorded. Findings of contrast-enhanced abdominopelvic computed tomography scan and laparotomy were assumed as a gold standard for @entity6 . RESULTS: A total of 104 @entity0 was enrolled in the study. 15 @entity0 (14.4%) had @entity3 and the mean plasma @entity5 level in this group was significantly higher than the other @entity0 on admission time (101.73    5.41  g/dL vs. 47.36    26.31  g/dL, P < 0.001). On receiver-operator characteristic curve analysis, in cutoff point of 89  g/dL, the sensitivity, specificity, positive and negative likelihood ratios were 100% (95% confidence interval [CI], 79.6-100), 93.26% (95% CI, 86-96.8), 14.83 (95% CI, 6.84-32.12), and 0, respectively. CONCLUSION: The study findings suggest the measurement of @entity5 level at the time of admission in the @entity0 with BAT would be a useful test predicting @entity3 . Furthermore, decrease in the @entity5 level could be a useful marker for monitoring response to treatment in these @entity0 .

title: Role of plasma XXXX level in detecting @entity3 following blunt @entity4 .

answer: @entity5


abstract: BACKGROUND: @entity7 is one of the main differential diagnoses in the investigation of nephrotic @entity2 in adults, especially elderly @entity0 . OBJECTIVES: The aim of this article is to contribute to international research with epidemiologic data of @entity7 , given the lack of uniformity described in the literature. @entity0 AND METHODS: A retrospective study of 37 cases of @entity7 diagnosed by kidney biopsy, between 2000 and 2011, considering epidemiological, clinical and laboratory data. RESULTS: Subjects aged between 32 and 80 years. Of the 37 cases, 21 (56.8%) were diagnosed as non-light chain (non- @entity6 ) @entity7 and 16 (43.2%) as light chain @entity6 ( @entity6 ). There was seen an increase in number of both @entity6 and non- @entity6 cases, with a slight predominance in non- @entity6 . The mean 24-hour @entity2 was 5839.0 mg/day. @entity4 was present in 75% of @entity0 . @entity1 was reported in 34% of @entity0 . @entity3 , occurred in about 10% of @entity0 , and chronic loss of renal function was present in about 5% at diagnosis. CONCLUSIONS: @entity7 is a disease of increasing incidence. The forms of clinical presentation proved to be variable, but the presence of @entity2 or @entity5 in elderly @entity0 should always prompt the suspicion of @entity7 and is a formal indication of renal biopsy.

title: Epidemiological, clinical and laboratorial profile of XXXX : a 12-year retrospective study of 37 cases.

answer: @entity7


abstract: BACKGROUND: To investigate and compare the period prevalences and incidences of optic disc @entity1 in normal tension @entity3 and primary @entity4 . DESIGN: Hospital-based retrospective study. @entity0 : Four hundred and four @entity0 with normal tension @entity3 and 210 @entity0 with primary @entity4 that underwent consecutive disc examinations at least quarterly for at least 1 year and stereoscopic optic disc photographs at intervals of 6 to 12 months between 1992 and 2007. METHODS: The period prevalence of disc @entity1 , gender predominance among @entity0 with disc @entity1 , and cumulative incidence of normal tension @entity3 and primary @entity4 were compared. MAIN OUTCOME MEASURES: Period prevalence, cumulative incidence, and gender predominance of DHs in @entity0 with NTG and @entity2 . RESULTS: Three hundred and eighty-seven @entity0 (387 eyes) of normal tension @entity3 @entity0 and 205 @entity0 (205 eyes) of primary @entity4 @entity0 were finally enrolled in the study. The period prevalence and incidence rates of the stereoscopic optic disc photograph-confirmed glaucomatous disc @entity1 were 33.3% (129/387), 0.46    0.18 times/year in the normal tension @entity3 group, and 17.6% (36/205), 0.34    0.23 times/year in the primary @entity4 group, respectively. The absolute values and ratios of primary @entity4 and normal tension @entity3 in period prevalences and incidence rates in the present study were higher than in previous studies. No significant difference in gender ratios was found between @entity0 that did or did not develop disc @entity1 for both types of @entity4 (P > 0.05, respectively). CONCLUSIONS: The primary @entity4 group had higher period prevalences and incidence rates of disc @entity1 than those reported previously. Disc @entity1 were found to develop independent of gender.

title: Period prevalence and incidence of optic disc @entity1 in normal tension @entity3 and primary XXXX .

answer: @entity4


abstract: BACKGROUND: To investigate and compare the period prevalences and incidences of optic disc @entity1 in normal tension @entity3 and primary @entity4 . DESIGN: Hospital-based retrospective study. @entity0 : Four hundred and four @entity0 with normal tension @entity3 and 210 @entity0 with primary @entity4 that underwent consecutive disc examinations at least quarterly for at least 1 year and stereoscopic optic disc photographs at intervals of 6 to 12 months between 1992 and 2007. METHODS: The period prevalence of disc @entity1 , gender predominance among @entity0 with disc @entity1 , and cumulative incidence of normal tension @entity3 and primary @entity4 were compared. MAIN OUTCOME MEASURES: Period prevalence, cumulative incidence, and gender predominance of DHs in @entity0 with NTG and @entity2 . RESULTS: Three hundred and eighty-seven @entity0 (387 eyes) of normal tension @entity3 @entity0 and 205 @entity0 (205 eyes) of primary @entity4 @entity0 were finally enrolled in the study. The period prevalence and incidence rates of the stereoscopic optic disc photograph-confirmed glaucomatous disc @entity1 were 33.3% (129/387), 0.46    0.18 times/year in the normal tension @entity3 group, and 17.6% (36/205), 0.34    0.23 times/year in the primary @entity4 group, respectively. The absolute values and ratios of primary @entity4 and normal tension @entity3 in period prevalences and incidence rates in the present study were higher than in previous studies. No significant difference in gender ratios was found between @entity0 that did or did not develop disc @entity1 for both types of @entity4 (P > 0.05, respectively). CONCLUSIONS: The primary @entity4 group had higher period prevalences and incidence rates of disc @entity1 than those reported previously. Disc @entity1 were found to develop independent of gender.

title: Period prevalence and incidence of optic disc @entity1 in normal tension XXXX and primary @entity4 .

answer: @entity3


abstract: BACKGROUND: To investigate and compare the period prevalences and incidences of optic disc @entity1 in normal tension @entity3 and primary @entity4 . DESIGN: Hospital-based retrospective study. @entity0 : Four hundred and four @entity0 with normal tension @entity3 and 210 @entity0 with primary @entity4 that underwent consecutive disc examinations at least quarterly for at least 1 year and stereoscopic optic disc photographs at intervals of 6 to 12 months between 1992 and 2007. METHODS: The period prevalence of disc @entity1 , gender predominance among @entity0 with disc @entity1 , and cumulative incidence of normal tension @entity3 and primary @entity4 were compared. MAIN OUTCOME MEASURES: Period prevalence, cumulative incidence, and gender predominance of DHs in @entity0 with NTG and @entity2 . RESULTS: Three hundred and eighty-seven @entity0 (387 eyes) of normal tension @entity3 @entity0 and 205 @entity0 (205 eyes) of primary @entity4 @entity0 were finally enrolled in the study. The period prevalence and incidence rates of the stereoscopic optic disc photograph-confirmed glaucomatous disc @entity1 were 33.3% (129/387), 0.46    0.18 times/year in the normal tension @entity3 group, and 17.6% (36/205), 0.34    0.23 times/year in the primary @entity4 group, respectively. The absolute values and ratios of primary @entity4 and normal tension @entity3 in period prevalences and incidence rates in the present study were higher than in previous studies. No significant difference in gender ratios was found between @entity0 that did or did not develop disc @entity1 for both types of @entity4 (P > 0.05, respectively). CONCLUSIONS: The primary @entity4 group had higher period prevalences and incidence rates of disc @entity1 than those reported previously. Disc @entity1 were found to develop independent of gender.

title: Period prevalence and incidence of optic disc XXXX in normal tension @entity3 and primary @entity4 .

answer: @entity1


abstract: PURPOSE: Task Group 204 introduced @entity1 ( @entity1 ) as the @entity0 size metric used to correlate size-specific-dose-estimates. However, this size metric fails to account for @entity0 attenuation properties and has been suggested to be replaced by an attenuation-based size metric, water equivalent diameter (DW). The purpose of this study is to investigate different size metrics, @entity1 , and water equivalent diameter, in combination with regional descriptions of scanner output to establish the most appropriate size metric to be used as a predictor for organ dose in tube current modulated CT exams. METHODS: 101 thoracic and 82 abdomen/pelvis scans from clinically indicated CT exams were collected retrospectively from a multidetector row CT (Sensation 64, Siemens Healthcare) with Institutional Review Board approval to generate voxelized @entity0 models. Fully irradiated organs (lung and breasts in thoracic scans and liver, kidneys, and spleen in abdominal scans) were segmented and used as tally regions in Monte Carlo simulations for reporting organ dose. Along with image data, raw projection data were collected to obtain tube current information for simulating tube current modulation scans using Monte Carlo methods. Additionally, previously described @entity0 size metrics [ @entity1 , DW, and approximated water equivalent diameter (DWa)] were calculated for each @entity0 and reported in three different ways: a single value averaged over the entire scan, a single value averaged over the region of interest, and a single value from a location in the middle of the scan volume. Organ doses were normalized by an appropriate mAs weighted CTDIvol to reflect regional variation of tube current. Linear regression analysis was used to evaluate the correlations between normalized organ doses and each size metric. RESULTS: For the abdominal organs, the correlations between normalized organ dose and size metric were overall slightly higher for all three differently (global, regional, and middle slice) reported DW and DWa than they were for @entity1 , but the differences were not statistically significant. However, for lung dose, computed correlations using water equivalent diameter calculated in the middle of the image data (DW,middle) and averaged over the low attenuating region of lung (DW,regional) were statistically significantly higher than correlations of normalized lung dose with @entity1 . CONCLUSIONS: To conclude, @entity1 and water equivalent diameter are very similar in abdominal regions; however, their difference becomes noticeable in lungs. Water equivalent diameter, specifically reported as a regional average and middle of scan volume, was shown to be better predictors of lung dose. Therefore, an attenuation-based size metric (water equivalent diameter) is recommended because it is more robust across different anatomic regions. Additionally, it was observed that the regional size metric reported as a single value averaged over a region of interest and the size metric calculated from a single slice/image chosen from the middle of the scan volume are highly correlated for these specific @entity0 models and scan types.

title: Attenuation-based size metric for estimating organ dose to XXXX undergoing tube current modulated CT exams.

answer: @entity0


abstract: BACKGROUND: @entity0 -reported outcome measures are increasingly used evaluating clinical care. Many measures used to assess operative hindfoot interventions vary in content, and some have not been psychometrically validated in this population. The purpose of this study was to compare measurement properties of 6 @entity3 @entity0 -reported outcome measures, and to evaluate their reliability and validity in light of @entity0 ' preferences. METHODS: Cross-sectional survey of 42 preoperative and 100 postoperative @entity0 completed 6 @entity3 outcome measures on 2 occasions: @entity5 ( @entity5 ), @entity4 ( @entity4 ), @entity0 -reported items of the @entity4 ( @entity4 ), Lower Extremity Functional Scale (LEFS), Western Ontario and McMaster Universities @entity2 Index (WOMAC), and the Short Musculoskeletal Function Assessment (SMFA), as well as measures of preference, and symptoms. RESULTS: Internal consistency was good to excellent for all scales and subscales (a = .84-.97; ICC [2,1] = .81-.96). Correlations between scales ranged from .50 (WOMACStiffness and FFIActivity Limitations) to .92 (LEFS and SMFAOverall, WOMACPain and AOSOverall, FFIOverall and AOFASOverall). Higher correlations occurred within instruments (r = .97 AOSPain and AOSOverall) and between similar subscales from different instruments (r = .91 WOMACPain and AOSPain). Construct validity showed moderate to high correlations to global ratings of @entity1 , Stiffness, and difficulty performing Daily Activities. The highest correlations (r > .75) occurred between @entity1 and AOSOverall (r = .84), stiffness and WOMACStiffness (r = .81), and Daily Activities and AOSDisability (r = .87). @entity0 rated instruments by preference. @entity5 , WOMAC, LEFS, and SMFA rated favorably for length. @entity5 , WOMAC, LEFS, and @entity4 rated high for understandability. @entity5 was rated by postoperative @entity0 as most likely to capture change due to surgery. SMFA rated the best overall. CONCLUSIONS: Direct comparison of instruments revealed similarity between scales in construct validity and reliability. @entity0 preferences supported the use of these scales. Foot-specific instruments offered no clear advantage over @entity3 instruments. LEVEL OF EVIDENCE: Level II, prospective comparative study.

title: Reliability and Validity of 6 Measures of XXXX , Function, and Disability for Ankle Arthroplasty and Arthrodesis.

answer: @entity1


abstract: OBJECTIVES: Although successful airway management is essential for emergency @entity1 care, comprehensive studies are limited. We sought to characterise current @entity1 care practice of airway management in the @entity2 ( @entity2 ) in Japan. DESIGN: Analysis of data from a prospective, observational, multicentre registry-the Japanese Emergency Airway Network (JEAN) registry. SETTING: 13 @entity5 and community @entity2 from different geographic regions across Japan. @entity0 : 723 @entity1 @entity0 who underwent emergency intubation from March 2010 through August 2012. OUTCOME MEASURES: ED characteristics, @entity0 and operator demographics, methods of airway management, intubation success or failure at each attempt and adverse events. RESULTS: A total of 723 @entity1 @entity0 who underwent emergency intubation were eligible for the analysis. Traumatic @entity3 comprised 32.6% (95% CI 29.3% to 36.1%) of @entity0 . @entity4 ( @entity4 ) was the initial method chosen in 23.9% (95% CI 21.0% to 27.2%) of all @entity1 @entity0 and in 35.5% (95% CI 31.4% to 39.9%) of @entity0 without @entity3 . Overall, intubation was successful in  <=3 attempts in 96% of @entity0 (95% CI 94.3% to 97.2%). There was a wide variation in the initial methods of intubation; @entity4 as the initial method was performed in 0-50.9% of all @entity1 @entity0 among 12 @entity2 . Similarly, there was a wide variation in success rates and adverse event rates across the @entity2 . Success rates varied between 35.5% and 90.5% at the first attempt, and 85.1% and 100% within three attempts across the 12 @entity2 . CONCLUSIONS: In this multicentre prospective study in Japan, we observed a high overall success rate in airway management during @entity1 care. However, the methods of intubation and success rates were highly variable among hospitals.

title: @entity1 airway management in XXXX : a multicentre, prospective, observational study in Japan.

answer: @entity2


abstract: OBJECTIVES: Although successful airway management is essential for emergency @entity1 care, comprehensive studies are limited. We sought to characterise current @entity1 care practice of airway management in the @entity2 ( @entity2 ) in Japan. DESIGN: Analysis of data from a prospective, observational, multicentre registry-the Japanese Emergency Airway Network (JEAN) registry. SETTING: 13 @entity5 and community @entity2 from different geographic regions across Japan. @entity0 : 723 @entity1 @entity0 who underwent emergency intubation from March 2010 through August 2012. OUTCOME MEASURES: ED characteristics, @entity0 and operator demographics, methods of airway management, intubation success or failure at each attempt and adverse events. RESULTS: A total of 723 @entity1 @entity0 who underwent emergency intubation were eligible for the analysis. Traumatic @entity3 comprised 32.6% (95% CI 29.3% to 36.1%) of @entity0 . @entity4 ( @entity4 ) was the initial method chosen in 23.9% (95% CI 21.0% to 27.2%) of all @entity1 @entity0 and in 35.5% (95% CI 31.4% to 39.9%) of @entity0 without @entity3 . Overall, intubation was successful in  <=3 attempts in 96% of @entity0 (95% CI 94.3% to 97.2%). There was a wide variation in the initial methods of intubation; @entity4 as the initial method was performed in 0-50.9% of all @entity1 @entity0 among 12 @entity2 . Similarly, there was a wide variation in success rates and adverse event rates across the @entity2 . Success rates varied between 35.5% and 90.5% at the first attempt, and 85.1% and 100% within three attempts across the 12 @entity2 . CONCLUSIONS: In this multicentre prospective study in Japan, we observed a high overall success rate in airway management during @entity1 care. However, the methods of intubation and success rates were highly variable among hospitals.

title: XXXX airway management in @entity2 : a multicentre, prospective, observational study in Japan.

answer: @entity1


abstract: @entity0 @entity4 ( @entity4 ) is determined by a wide variety of environmental and genetic factors. Nutrient limitation without @entity3 , i.e. dietary restriction, expands @entity4 through the control of nutrient signaling pathways, of which TOR/ @entity6 has proven to be the most relevant, particularly under @entity2 deprivation. The use of prototrophic wine @entity0 allows a better understanding of the role of @entity2 in longevity in natural and more demanding environments, such as grape juice fermentation. We previously showed that acetyltransferase Gcn5, a member of the SAGA complex, has opposite effects on @entity4 under laboratory and winemaking conditions, and is detrimental under the latter. Here we demonstrate that integrity of the SAGA complex is necessary for prolonged longevity, as its dismantling by @entity7 deletion causes a drop in @entity4 under both laboratory and winemaking conditions. The @entity6   mutant is long-lived in synthetic SC medium, as expected, and the combined deletion of GCN5 partially suppresses this phenotype. However it is short-lived in grape juice, likely due to its low @entity2 / @entity1 ratio. Therefore, unbalance of nutrients can be more relevant for life span than total amounts of them. Deletion of @entity5 , which codes for a protein associated with Gcn5 and is a component of the mitochondrial retrograde signal, and which communicates mitochondrial dysfunction to the nucleus, is detrimental under laboratory, but not under winemaking conditions, where respiration seems not so relevant for longevity. Transcription factor @entity8 was found to be a novel @entity4 regulator @entity6 -dependently.

title: Interplay among Gcn5, @entity6 and Mitochondria during Chronological Aging of Wine XXXX Is Dependent on Growth Conditions.

answer: @entity0


abstract: @entity0 @entity4 ( @entity4 ) is determined by a wide variety of environmental and genetic factors. Nutrient limitation without @entity3 , i.e. dietary restriction, expands @entity4 through the control of nutrient signaling pathways, of which TOR/ @entity6 has proven to be the most relevant, particularly under @entity2 deprivation. The use of prototrophic wine @entity0 allows a better understanding of the role of @entity2 in longevity in natural and more demanding environments, such as grape juice fermentation. We previously showed that acetyltransferase Gcn5, a member of the SAGA complex, has opposite effects on @entity4 under laboratory and winemaking conditions, and is detrimental under the latter. Here we demonstrate that integrity of the SAGA complex is necessary for prolonged longevity, as its dismantling by @entity7 deletion causes a drop in @entity4 under both laboratory and winemaking conditions. The @entity6   mutant is long-lived in synthetic SC medium, as expected, and the combined deletion of GCN5 partially suppresses this phenotype. However it is short-lived in grape juice, likely due to its low @entity2 / @entity1 ratio. Therefore, unbalance of nutrients can be more relevant for life span than total amounts of them. Deletion of @entity5 , which codes for a protein associated with Gcn5 and is a component of the mitochondrial retrograde signal, and which communicates mitochondrial dysfunction to the nucleus, is detrimental under laboratory, but not under winemaking conditions, where respiration seems not so relevant for longevity. Transcription factor @entity8 was found to be a novel @entity4 regulator @entity6 -dependently.

title: Interplay among Gcn5, XXXX and Mitochondria during Chronological Aging of Wine @entity0 Is Dependent on Growth Conditions.

answer: @entity6


abstract: This study attempted to elucidate the etiology of @entity1 by examining its association with a number of factors in a relatively unselected group of @entity0 . In 1963, a cytologic screening program was undertaken in Washington County, Maryland. The irrigation smear method was used. The final study group of 4341 was 46% of all white @entity0 aged 30-45 years enumerated in the census. Of the 4290 satisfactory smears, 46 were positive or suspicious. Subsequent investigation confirmed 31 cases of which 28 were at Stage 0 and 3 were invasive @entity2 . Of 15 with suspicious cytologic findings 6 had confirmed findings, all of which were at Stage 0. @entity0 who were never married had no confirmed cases. Currently-married @entity0 had lower rates than @entity0 whose marriages had been disrupted. Those who were married at age 16 or earlier had higher rates of @entity1 as did those from lower socioeconomic levels. Having had multiple sex partners was associated with an increased risk of developing @entity1 . Smokers had slightly higher rates than nonsmokers. Trichomonas @entity3 was associated with higher rates. Findings indicate that trichomoniasis and @entity1 are both associated with sexual activity.

title: Relation of XXXX as determined by a screening program.

answer: @entity1


abstract: UNASSIGNED: The therapeutic spectrum of this disorder consists of medical therapy, @entity2 , endoscopic Botox injection, open or laparoscopic @entity3 , and most recently transesophageal endoscopic myotomy ( @entity6 peroral endoscopic myotomy). The most important requirement is a well-experienced team in interventional flexible endoscopy. The endoscopist as well as the assisting staff should have experience in advanced therapeutic endoscopic techniques and hemostasis to handle all necessary endoscopic instruments such as injection needles, needle knife, triangle knife, coagulation graspers, and endoscopic clip handling and closures. In addition, advanced surgical and especially laparoscopic skills and experience as well as surgical knowledge about @entity4 must be available in case of conversion and/or consultation. Prior to this procedure, the @entity0 undergoes a detailed diagnostic work-up to confirm the diagnosis of @entity5 . The procedures are performed in general anesthesia. The @entity0 is brought in a supine position, and the abdomen is free for inspection and palpation during the procedure. The myotomy can be performed in different locations around the esophageal circumference. In Europe, several centers with large experience in @entity4 , laparoscopy, and especially advanced interventional endoscopy have started to introduce this @entity6 -technique in their clinical practice. Initial success and low complication rates are quite promising and show a great future perspective for this technique. In the USA, @entity6 is a procedure with a substantial increase in numbers performed in the past years with a low complication rate. The largest series are performed in Asia with a great clinical success. The perspective of @entity6 may be the lesser access @entity1 . Its potential can be also realized in Redo cases, where experienced centers have initial experience with @entity6 after @entity6 and @entity6 after LHMD.

title: The Potential and Perspective of Peroral Endoscopic Esophageal Myotomy for XXXX .

answer: @entity5


abstract: BACKGROUND: Surgical audit is an essential task for the estimation of postoperative outcome and comparison of quality of care. Previous studies on surgical audits focused on short-term outcomes, such as postoperative mortality. We propose a surgical audit evaluating long-term outcome following @entity2 surgery. The predictive model for this audit is designated as 'Estimation of Postoperative Overall Survival for @entity2 (EPOS-CC)'. METHODS: Thirty-one @entity1 -related and physiological variables were prospectively collected in 889 @entity0 undergoing elective resection for @entity2 between April 2005 and April 2007 in 16 Japanese hospitals. Postoperative overall survival was assessed over a 5-years period. The EPOS-CC score was established by selecting significant variables in a uni- and multivariate analysis and allocating a risk-adjusted multiplication factor to each variable using Cox regression analysis. For validation, the EPOS-CC score was compared to the predictive power of UICC stage. Inter-hospital variability of the observed-to-estimated 5-years survival was assessed to estimate quality of care. RESULTS: Among the 889 @entity0 , 804 (90  %) completed the 5-years follow-up. Univariate analysis displayed a significant correlation with 5-years survival for 14 physiological and nine @entity1 -related variables (p  <  0.005). Highly significant p-values below 0.0001 were found for age, ASA score, severe @entity3 , respiratory history, performance status, @entity6 , alteration of hemoglobin, serum @entity4 level, and for all histological variables except @entity1 location. Age, @entity5 stage, lymphatic invasion, performance status, and serum @entity4 level were independent variables in the multivariate analysis and were entered the EPOS-CC model for the prediction of survival. Risk-adjusted multiplication factors between 1.5 (distant metastasis) and 0.16 (serum @entity4 level) were accorded to the different variables. The predictive power of EPOS-CC was superior to the one of UICC stage; area under the curve 0.87, 95  % CI 0.85-0.90 for EPOS-CC, and 0.80, 0.76-0.83 for UICC stage, p  <  0.001. Quality of care did not differ between hospitals. CONCLUSIONS: The EPOS-CC score including the independent variables age, performance status, serum @entity4 level, @entity5 stage, and lymphatic invasion is superior to the UICC stage in the prediction of 5-years overall survival. This higher accuracy might be explained by the inclusion of physiological factors, thus also taking non- @entity1 -associated deaths into account. Furthermore, EPOS-CC score may compare quality of care among different institutions. Future studies are necessary to further evaluate this score and help improving the prediction of long-term survival following @entity2 surgery.

title: The EPOS-CC Score: An Integration of Independent, Tumor- and @entity0 -Associated Risk Factors to Predict 5-years Overall Survival Following XXXX .

answer: @entity2


abstract: BACKGROUND: Surgical audit is an essential task for the estimation of postoperative outcome and comparison of quality of care. Previous studies on surgical audits focused on short-term outcomes, such as postoperative mortality. We propose a surgical audit evaluating long-term outcome following @entity2 surgery. The predictive model for this audit is designated as 'Estimation of Postoperative Overall Survival for @entity2 (EPOS-CC)'. METHODS: Thirty-one @entity1 -related and physiological variables were prospectively collected in 889 @entity0 undergoing elective resection for @entity2 between April 2005 and April 2007 in 16 Japanese hospitals. Postoperative overall survival was assessed over a 5-years period. The EPOS-CC score was established by selecting significant variables in a uni- and multivariate analysis and allocating a risk-adjusted multiplication factor to each variable using Cox regression analysis. For validation, the EPOS-CC score was compared to the predictive power of UICC stage. Inter-hospital variability of the observed-to-estimated 5-years survival was assessed to estimate quality of care. RESULTS: Among the 889 @entity0 , 804 (90  %) completed the 5-years follow-up. Univariate analysis displayed a significant correlation with 5-years survival for 14 physiological and nine @entity1 -related variables (p  <  0.005). Highly significant p-values below 0.0001 were found for age, ASA score, severe @entity3 , respiratory history, performance status, @entity6 , alteration of hemoglobin, serum @entity4 level, and for all histological variables except @entity1 location. Age, @entity5 stage, lymphatic invasion, performance status, and serum @entity4 level were independent variables in the multivariate analysis and were entered the EPOS-CC model for the prediction of survival. Risk-adjusted multiplication factors between 1.5 (distant metastasis) and 0.16 (serum @entity4 level) were accorded to the different variables. The predictive power of EPOS-CC was superior to the one of UICC stage; area under the curve 0.87, 95  % CI 0.85-0.90 for EPOS-CC, and 0.80, 0.76-0.83 for UICC stage, p  <  0.001. Quality of care did not differ between hospitals. CONCLUSIONS: The EPOS-CC score including the independent variables age, performance status, serum @entity4 level, @entity5 stage, and lymphatic invasion is superior to the UICC stage in the prediction of 5-years overall survival. This higher accuracy might be explained by the inclusion of physiological factors, thus also taking non- @entity1 -associated deaths into account. Furthermore, EPOS-CC score may compare quality of care among different institutions. Future studies are necessary to further evaluate this score and help improving the prediction of long-term survival following @entity2 surgery.

title: The EPOS-CC Score: An Integration of Independent, Tumor- and XXXX -Associated Risk Factors to Predict 5-years Overall Survival Following @entity2 .

answer: @entity0


abstract: INTRODUCTION: The aim of this study was to investigate the association between alcoholic and non-alcoholic beverages and knee or @entity1 ( @entity2 ). METHODS: We conducted a case-control study of Caucasian @entity0 and @entity0 aged 45 to 86 years of age from Nottingham, UK. Cases had clinically severe symptoms and radiographic knee or hip @entity2 ; controls had no symptoms and no radiographic knee or hip @entity2 . Exposure information was sought using interview-based questionnaires and a semi-quantitative food frequency questionnaire to assess beverage consumption at ages 21 to 50 years. Odds ratios (ORs), adjusted ORs (aORs), 95% confidence intervals (CI) and P values were estimated using logistic regression models. RESULTS: A total of 1,001 knee @entity2 , 993 hip @entity2 and 933 control @entity0 were included in the study. Increasing beer consumption was associated with an increasing risk of @entity2 (P for trend <=0.001). Compared to those who did not consume beer, aORs for @entity0 who consumed 20 or more servings of beer were 1.93 (95% CI 1.26 to 2.94) and 2.15 (95% CI 1.45 to 3.19) for knee @entity2 and hip @entity2 , respectively. In contrast, increasing levels of wine consumption were associated with decreased likelihood of knee @entity2 (P for trend<0.001). Compared to those who did not consume wine, aOR for knee @entity2 among those who consumed 4 to 6 glasses of wine per week and >= 7 glasses of wine per week was 0.55 (95% CI 0.34 to 0.87) and 0.48 (95% CI 0.29 to 0.80), respectively. No association was identified between non-alcoholic beverages and knee or hip @entity2 . CONCLUSIONS: Beer consumption appears to be a risk factor for knee and hip @entity2 whereas consumption of wine has a negative association with knee @entity2 . The mechanism behind these findings is speculative but warrants further study.

title: Beer and wine consumption and risk of knee or XXXX : a case control study.

answer: @entity1


abstract: UNASSIGNED: @entity1 ( @entity1 ) is a common complication of surgery. Endothelial progenitor cells (EPCs) are recruited into resolving venous thrombi. In this report, we investigated the effects of @entity3 on EPCs function and venous @entity0 resolution. We demonstrated that overexpression of @entity3 enhanced EPCs' migration and tubulogenic activity in vitro, and promoted EPCs' homing and @entity0 resolving in vivo. Moreover, we identified that @entity3 directly targeted @entity2 and affected @entity4 /Akt signaling axis. Overall, our findings demonstrated that @entity3 promoted EPCs function through suppressing @entity2 expression and modulation of @entity3 may represent a potential therapeutic intervention for treating @entity1 . J. Cell. Biochem. 116: 1613-1623, 2015.    2015 Wiley Periodicals, Inc.

title: Upregulation of MicroRNA-126 Contributes to Endothelial Progenitor Cell Function in @entity1 via Its Target XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity1 ( @entity1 ) is a common complication of surgery. Endothelial progenitor cells (EPCs) are recruited into resolving venous thrombi. In this report, we investigated the effects of @entity3 on EPCs function and venous @entity0 resolution. We demonstrated that overexpression of @entity3 enhanced EPCs' migration and tubulogenic activity in vitro, and promoted EPCs' homing and @entity0 resolving in vivo. Moreover, we identified that @entity3 directly targeted @entity2 and affected @entity4 /Akt signaling axis. Overall, our findings demonstrated that @entity3 promoted EPCs function through suppressing @entity2 expression and modulation of @entity3 may represent a potential therapeutic intervention for treating @entity1 . J. Cell. Biochem. 116: 1613-1623, 2015.    2015 Wiley Periodicals, Inc.

title: Upregulation of MicroRNA-126 Contributes to Endothelial Progenitor Cell Function in XXXX via Its Target @entity2 .

answer: @entity1


abstract: PURPOSE: To determine the effect of 1% @entity3 on the refractive status of @entity0 aged 4 to 18 years. METHODS: Using a random cluster sampling in a cross-sectional school-based study design, @entity0 with an age of 4-18 years were selected from kindergardens, primary schools, junior and senior high schools in a rural county and a city. Auto-refractometry was performed before and after inducing cycloplegia which was achieved by 1% cyclopentolate eye drops. RESULTS: Out of 6364 eligible @entity0 , data of 5999 (94.3%) @entity0 were included in the statistical analysis. Mean age was 10.0  3.3 years (range: 4-18 years). Mean difference between cycloplegic and non-cycloplegic @entity2 (DIFF) was 0.78  0.79D (median: 0.50D; range: -1.00D to +10.75D). In univariate analysis, DIFF decreased significantly with older age (P<0.001;correlation coefficient r:-0.24), more hyperopic non-cycloplegic @entity2 (P<0.001;r = 0.13) and more @entity2 (P<0.001;r = 0.49). In multivariate analysis, higher DIFF was associated with higher cycloplegic @entity2 (P<0.001; standardized regression coefficient beta:0.50; regression coefficient B: 0.19; 95% confidence interval (CI): 0.18, 0.20), followed by lower intraocular pressure (P<0.001; beta: -0.06; B: -0.02; 95%CI: -0.03, -0.01), rural region of habitation (P = 0.001; beta: -0.04; B: -0.07; 95%CI: -0.11, -0.03), and, to a minor degree, with age (P = 0.006; beta: 0.04; B: 0.009; 95%CI: 0.003, 0.016). 66.4% of all eyes with non-cycloplegic @entity1 ( <=-0.50D) remained myopic after cycloplegia while the remaining 33.6% of eyes became emmetropic (18.0%) or hyperopic (15.7%) under cycloplegia. Prevalence of emmetropia decreased from 37.5% before cycloplegia to 19.8% after cycloplegia while the remaining eyes became hyperopic under cycloplegia. CONCLUSIONS: The error committed by using non-cycloplegic versus cycloplegic refractometry in @entity0 with mid to dark-brown iris color decreased with older age, and in parallel manner, with more @entity2 . Non-cycloplegic refractometric measures lead to a misclassification of @entity2 in a significant proportion of @entity0 .

title: Effect of cycloplegia on the refractive status of XXXX : the shandong @entity0 eye study.

answer: @entity0


abstract: PURPOSE: To determine the effect of 1% @entity3 on the refractive status of @entity0 aged 4 to 18 years. METHODS: Using a random cluster sampling in a cross-sectional school-based study design, @entity0 with an age of 4-18 years were selected from kindergardens, primary schools, junior and senior high schools in a rural county and a city. Auto-refractometry was performed before and after inducing cycloplegia which was achieved by 1% cyclopentolate eye drops. RESULTS: Out of 6364 eligible @entity0 , data of 5999 (94.3%) @entity0 were included in the statistical analysis. Mean age was 10.0  3.3 years (range: 4-18 years). Mean difference between cycloplegic and non-cycloplegic @entity2 (DIFF) was 0.78  0.79D (median: 0.50D; range: -1.00D to +10.75D). In univariate analysis, DIFF decreased significantly with older age (P<0.001;correlation coefficient r:-0.24), more hyperopic non-cycloplegic @entity2 (P<0.001;r = 0.13) and more @entity2 (P<0.001;r = 0.49). In multivariate analysis, higher DIFF was associated with higher cycloplegic @entity2 (P<0.001; standardized regression coefficient beta:0.50; regression coefficient B: 0.19; 95% confidence interval (CI): 0.18, 0.20), followed by lower intraocular pressure (P<0.001; beta: -0.06; B: -0.02; 95%CI: -0.03, -0.01), rural region of habitation (P = 0.001; beta: -0.04; B: -0.07; 95%CI: -0.11, -0.03), and, to a minor degree, with age (P = 0.006; beta: 0.04; B: 0.009; 95%CI: 0.003, 0.016). 66.4% of all eyes with non-cycloplegic @entity1 ( <=-0.50D) remained myopic after cycloplegia while the remaining 33.6% of eyes became emmetropic (18.0%) or hyperopic (15.7%) under cycloplegia. Prevalence of emmetropia decreased from 37.5% before cycloplegia to 19.8% after cycloplegia while the remaining eyes became hyperopic under cycloplegia. CONCLUSIONS: The error committed by using non-cycloplegic versus cycloplegic refractometry in @entity0 with mid to dark-brown iris color decreased with older age, and in parallel manner, with more @entity2 . Non-cycloplegic refractometric measures lead to a misclassification of @entity2 in a significant proportion of @entity0 .

title: Effect of cycloplegia on the refractive status of @entity0 : the shandong XXXX eye study.

answer: @entity0


abstract: BACKGROUND: @entity3 ( @entity3 ) temporary abutments have been recently introduced for making implant-supported provisional single crowns. Little information is available in the dental literature on the durability of provisional implant-supported restorations. PURPOSE: The objectives of this study were to evaluate the @entity0 strength of implant-supported composite resin crowns on PEEK and solid @entity2 temporary abutments, and to analyze the failure types. MATERIAL AND METHODS: Three types of provisional abutments, RN synOcta Temporary Meso Abutment (PEEK; Straumann), RN synOcta @entity2 Post for Temporary Restorations (Straumann), and Temporary Abutment Engaging NobRplRP (Nobel Biocare) were used, and provisional screw-retained crowns using composite resin (Solidex) were fabricated for four different locations in the maxilla. The specimens were tested in a universal testing machine at a crosshead speed of 1 mm/minute until @entity0 occurred. The failure types were analyzed and further categorized as irreparable (Type 1) or reparable (Type 2). RESULTS: No significant difference was found between different abutment types. Only for the position of the maxillary central incisor, composite resin crowns on PEEK temporary abutments showed significantly lower (p < 0.05) @entity0 strength (95    21 N) than those on @entity2 temporary abutments (1,009    94 N). The most frequently experienced failure types were @entity0 (75 out of 104), followed by screw loosening (18 out of 104). According to reparability, the majority of the specimens were classified as Type 1 (82 out of 104). @entity1 were not often observed (22 out of 104). CONCLUSIONS: Provisional crowns on PEEK abutments showed similar @entity0 strength as @entity2 temporary abutments except for central incisors. Maxillary right central incisor composite resin crowns on PEEK temporary abutments fractured below the mean anterior masticatory loading forces reported to be approximately 206 N.

title: Fracture strength and failure mode of maxillary implant-supported provisional single crowns: a comparison of composite resin crowns fabricated directly over PEEK abutments and solid XXXX abutments.

answer: @entity2


abstract: INTRODUCTION: @entity2 has been paid to the psychological status of @entity1 @entity0 from developing countries who have been traditionally stigmatized as feeble and ineffective. AIM: The aim of this study is to evaluate the prevalence of @entity3 and its socio-demographic correlates in a sample of Iranian @entity1 @entity0 . METHODS: One hundred and fourteen @entity1 @entity0 filled out the 21-item Beck @entity3 Inventory. @entity0 who scored >=  17 were considered @entity3 and those with the score  <= 16 were assumed to be nondepressed. MAIN OUTCOME MEASURES: (i) Comparison between @entity3 and non- @entity3 @entity0 regarding age, education level, economic status, ethnicity, age at time of marriage, duration, and @entity1 and regular cigarette smoking. (ii) Independent risk factors for @entity3 . RESULTS: The mean age of @entity0 was 34.1    7.1 years. The diagnosis of @entity3 was made in 42.9% of @entity1 @entity0 . Current age, age at marriage, economic status, and @entity1 were not statistically different between two groups (P > 0.05). Statistically significant association was detected between @entity3 symptoms and education (P < 0.001), cigarette smoking (P < 0.008), and duration of @entity1 (P < 0.03). In an adjusted multiple regression model, education (odds ratio [OR] 0.2; confidence interval [CI] 0.06-0.5, P < 0.003), ethnicity (OR 4.5; CI 1.5-13.3, P < 0.006), and cigarette smoking (OR 5.1; CI 1.4-18.5, P < 0.01) retained their significance, while duration of @entity1 lost its power. CONCLUSION: @entity3 among Iranian @entity1 @entity0 is remarkably higher in comparison with Western countries. Azaris, cigarette smokers, and individuals with low educational level are at higher risk of developing @entity3 among @entity1 @entity0 .

title: Male infertility and XXXX : a neglected problem in the Middle East.

answer: @entity3


abstract: UNASSIGNED: The ubiquitin proteasome system in plants plays important roles in plant-microbe interactions and in immune responses to pathogens. We previously demonstrated that the @entity2 U-box E3 ligase SPL11 and its @entity3 ortholog @entity8 negatively regulate @entity1 ( @entity1 ) and defense response. However, the components involved in the SPL11/ @entity8 -mediated @entity1 and immune signaling pathway remain unknown. In this study, we report that SPL11-interacting Protein 6 (SPIN6) is a Rho GTPase-activating protein (RhoGAP) that interacts with SPL11 in vitro and in vivo. SPL11 ubiquitinates SPIN6 in vitro and degrades SPIN6 in vivo via the 26S proteasome-dependent pathway. Both RNAi silencing in transgenic @entity2 and knockout of Spin6 in a T-DNA insertion mutant lead to @entity1 and increased resistance to the @entity2 blast pathogen @entity6 and the bacterial blight pathogen @entity7 . oryzae. The levels of reactive @entity0 species and defense-related gene expression are significantly elevated in both the Spin6 RNAi and mutant plants. Strikingly, SPIN6 interacts with the small GTPase OsRac1, catalyze the @entity5 -bound OsRac1 into the @entity4 -bound state in vitro and has GAP activity towards OsRac1 in @entity2 cells. Together, our results demonstrate that the RhoGAP SPIN6 acts as a linkage between a U-box E3 ligase-mediated ubiquitination pathway and a small GTPase-associated defensome system for plant immunity.

title: The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in XXXX .

answer: @entity2