abstract: BACKGROUND: The hyperinflammation that begins with @entity2 is essential for eradicating @entity1 but also causes hypoperfusion and organ failure. To understand the innate immune status of septic @entity0 , the functional and phenotypic changes of neutrophils during @entity2 and their clinical implication were studied. METHODS: Seventy-four @entity0 who were admitted to intensive care unit due to severe @entity2 or @entity3 were enrolled. Surface antigens of neutrophils ( @entity7 , @entity5 , and @entity6 ) were detected by flow cytometry. Respiratory burst activity (RBA) was measured by flow cytometry using @entity8 and @entity4 . The parameters were serially examined at Days 1 and 8 in @entity3 @entity0 . RESULTS: High @entity7 and low @entity5 and @entity6 on Day 1 was associated with @entity2 severity (P   =   0.003, 0.017, and 0.007, respectively). On Day 1, RBA and @entity7 were higher in survivors than in nonsurvivors of @entity3 @entity0 (P   =   0.012 and 0.027, respectively), and on Day 8, @entity5 and @entity6 were higher in survivors than in nonsurvivors (P   =   0.019 and 0.036, respectively). High RBA and high @entity7 on Day 1 showed low 28-day mortality in univariate analysis (P   =   0.018 and 0.034, respectively). In multivariate analysis, RBA maintained statistical significance (P   =   0.042) but @entity7 revealed only a tendency (P   =   0.064). CONCLUSIONS: Neutrophil surface antigen ( @entity7 , @entity5 , and @entity6 ) could reflect @entity2 severity. High @entity7 expression and high RBA at early phase of @entity2 might be associated with better prognosis, whereas high expression of @entity5 and @entity6 at late phase of @entity2 might be associated with better prognosis.    2015 International Clinical Cytometry Society.

title: Flow cytometric measurement of respiratory burst activity and surface expression of neutrophils for septic XXXX prognosis.

answer: @entity0


abstract: UNASSIGNED: Although a complete thoracic spinal cord section in various mammals induces paralysis of @entity2 , the spinal lumbosacral circuitry below the lesion retains its ability to generate hindlimb locomotion. This important capacity may contribute to the overall locomotor recovery after partial @entity3 ( @entity3 ). In @entity1 , it is usually triggered by pharmacological and/or electrical stimulation of the cord while a robot sustains the animals in an upright posture. In the present study we daily trained a group of adult spinal (T7) @entity1 to walk with the hindlimbs for 10 wk (10 min/day for 5 days/wk), using only perineal stimulation. Kinematic analysis and terminal electromyographic recordings revealed a strong effect of training on the reexpression of hindlimb locomotion. Indeed, trained animals gradually improved their locomotion while untrained animals worsened throughout the post- @entity3 period. Kinematic parameters such as averaged and instant swing phase velocity, step cycle variability, foot drag duration, off period duration, and relationship between the swing features returned to normal values only in trained animals. The present results clearly demonstrate that treadmill training alone, in a normal horizontal posture, elicited by noninvasive perineal stimulation is sufficient to induce a persistent hindlimb locomotor recovery without the need for more complex strategies. This provides a baseline level that should be clearly surpassed if additional locomotor-enabling procedures are added. Moreover, it has a clinical value since intrinsic spinal reorganization induced by training should contribute to improve locomotor recovery together with afferent feedback and supraspinal modifications in @entity0 with incomplete @entity3 .

title: Inducing hindlimb locomotor recovery in adult XXXX after complete thoracic spinal cord section using repeated treadmill training with perineal stimulation only.

answer: @entity1


abstract: AIM OF THE STUDY: @entity4 are relatively rare, and their geographic distribution varies greatly around the world. In this study, we present the incidence, age distribution and localization of @entity4 diagnosed and/or treated at a tertiary referral orthopedic department, catering to an entire Southeastern European country. METHODS: This was a retrospective study of prospectively collected data, in which all @entity0 diagnosed and/or treated for @entity4 at our Department in the period of 30 years (1981-2010) were included. RESULTS: Data of a total of 3482 @entity0 with @entity4 were collected. Average age of @entity0 was 33.5 years (range, 2 months-88 years), with even distribution according to sex. @entity1 were seen in 20.7% of @entity0 , more often in @entity0 (56.9%). Most common @entity1 were @entity5 (estimated incidence: 1.68/million/year), @entity6 (0.79/million/year) and @entity8 (0.76/million/year). @entity1 and @entity1 -like lesions were found in 79.3% of @entity0 , with slight female predominance. Most common @entity2 were @entity7 (5.81/million/year), simple bone cyst (2.13/million/year), and @entity3 (2.05/million/year). CONCLUSION: This report represents a first of its kind in our region, and gives representative results to be compared to other middle and south European countries. Further nationwide studies are needed to improve strategies in @entity9 diagnosis and treatment.

title: Epidemiology of XXXX in a national referral orthopedic department. A study of 3482 cases.

answer: @entity4


abstract: PURPOSE: To describe the efficacy of combined excimer laser photoablation and amniotic overlay membrane in the relief of symptomatic discomfort in a 17-year-old @entity0 who had @entity3 . METHODS: The best-corrected visual acuity (BCVA) was measured with Snellen letters. Slit-lamp examination of the ocular surface and anterior chamber was performed at baseline. Results were photodocumented. Excimer laser photoablation was performed and subsequently 2 amniotic membranes were transconjunctivally fixated with 10.0 nylon sutures. Investigations and documentation were performed at baseline, every 2 months in the first year, and then every 6 months. The duration of follow-up was 22 months. RESULTS: At baseline, the BCVA was 20/70 in the right eye and 20/200 in the left eye. The @entity0 reported distinct @entity1 . Slit-lamp examination was difficult because of @entity2 . Although gelatinous drops developed again and the BCVA decreased to 2/200, the @entity0 reported significant relief after both microsurgical treatments and remained comfortable at 20 and 22 months. CONCLUSIONS: Excimer laser photocoagulation combined with amniotic membrane overlay does not stop the development of @entity3 but may improve subjective comfort. Such treatment does not hinder subsequent lamellar or penetrating grafts and is helpful in providing the necessary time for preparation of matched keratoplasties.

title: Combined Excimer Laser Photoablation and Amniotic Membrane Overlay for Relief of Symptomatic Discomfort in XXXX .

answer: @entity3


abstract: The aim of this research was to examine the mediating roles played by a range of biographic and illness-related factors in preferences for strategies for coping with @entity1 . @entity1 @entity0 assessed their own coping strategy preference by ranking six clusters of strategies. Information was also obtained about their demographic characteristics, life styles, illness roles, the degree of their disability, their perceived handicaps and their perceived achievement of their rehabilitation goals. Multiple regression analyses of each of these six sets of variables on each coping strategy were carried out to identify patterns of association between them. (1) Preferences for action strategies were found to be associated with @entity0 -related factors (demographic characteristics, life style and illness role). (2) Control strategies were associated with illness-related factors (illness role, degree of disability, perceived handicap and achievement of rehabilitation goals). (3) Escape strategies were ranked higher by @entity0 than by @entity0 , sex being their only significant predictor. (4) Preferences for @entity2 , unlike those for action strategies, were associated with relatively low social status and relatively little interpersonal involvement or social commitment. (5) Preferences for optimism were related only to @entity0 ' perceptions of their handicaps. (6) Interpersonal coping was not found to be associated with any of this wide range of biographic illness-related factors.

title: Coping with XXXX : the mediating role of biographic and illness-related factors.

answer: @entity1


abstract: Background: There is a need for improved clinical identification of hospitalized @entity0 at risk of @entity1 . We evaluated our novel phonetic test in a broad spectrum of intensive or intermediate care unit @entity0 at risk for @entity1 . Methods: We prospectively enrolled 60 hospitalized @entity0 with @entity1 risk, between December 2009 and September 2011, who subsequently underwent audio-recorded 3-component phonetic bedside evaluation. The recordings were scored by two blinded speech-language pathologists. The institutional " @entity3 Admission Screening Test" was performed by a bedside nurse. The primary outcomes, @entity3 and @entity1 , were assessed by videofluoroscopic swallowing study and/or fiberoptic endoscopic evaluation of swallowing. We assessed the short and long-term clinical outcomes (length of stay, subsequent @entity2 and @entity4 , survival), and how these associated with the phonetic and swallow assessments. Results: Statistically significant linear associations with @entity3 were noted for all three individual phonetic components. Also, there were statistically significant linear associations with @entity1 for diadochokinesis (P=0.050) and Consensus Auditory-Perceptual Evaluation of voice (P=0.025). Diadochokinesis alone predicted @entity3 (AUC: 0.74, P=0.001) and @entity1 (AUC: 0.67, P=0.012). Its predictive ability improved when combined with normalized @entity3 admission screening test results (AUC: 0.79, P=0.001). The short and long-term clinical outcomes were adversely affected by the worse phonetic/swallowing scores, though not statistically different. Conclusions: Abnormal phonation among intensive and intermediate care unit @entity0 is associated with @entity3 and @entity1 . Future investigative efforts should uncover the most effective combination of evaluations for accurate bedside detection of @entity3 and @entity1 risk in a broad spectrum of @entity0 .

title: Novel Bedside Phonetic Evaluation to Identify XXXX and Aspiration Risk.

answer: @entity3


abstract: BACKGROUND: @entity3 ( @entity3 ) remains a significant problem in limited @entity2 (LD- @entity8 ) @entity0 treated with definitive chemoradiotherapy. Dose-escalation may be a way forward to reduce the failure rate. However, the risk of @entity1 rises with increasing doses. Knowledge on factors associated with @entity3 could aid the selection of @entity0 for more aggressive treatment. Therefore, the aim of this study is to evaluate factors correlated with @entity3 in a cohort of LD- @entity8 @entity0 treated with definitive chemoradiotherapy. Moreover, factors associated with improved survival were investigated. MATERIAL AND METHODS: We included 147 consecutive LD- @entity8 @entity0 treated from 2007 to 2013. Radiotherapy was delivered as either 45 Gy in 1.5-Gy fractions twice daily or 46-50 Gy in 2-Gy fractions once daily. Chemotherapy was @entity6 combined with either @entity7 or @entity4 given mainly concomitantly with radiotherapy. Pattern of first failure and survival were evaluated retrospectively. @entity9 ( @entity9 ) and @entity5 ( @entity5 ) were calculated by the Kaplan-Meier method. The impact of covariates on @entity3 and @entity5 was evaluated by using Cox proportional hazards model. RESULTS: With a median follow-up time of 42.2 months, 37 @entity0 experienced @entity3 as first failure. Isolated @entity3 was seen in 16 @entity0 , but no isolated regional failure was seen. The @entity9 rate was 22% at 1-year and 43% at 3-years. N3-stage was an independent prognostic factor correlated with @entity3 development (p = 0.043). Median @entity5 was 24.1 months (95% CI 19-29 months) and a three-year survival of 34%. Prognostic factors associated with improved @entity5 were staging including a positron emission tomography (PET) scan (p = 0.004) and receiving prophylactic cranial irradiation (PCI) (p = 0.006). CONCLUSION: N3-stage was an independent prognostic factor for @entity3 . Receiving a pretreatment PET scan and receiving PCI were prognostic factors for improved @entity5 . Reduction in @entity3 may be achieved with dose-escalation in @entity0 with N3-stage. This can be evaluated in prospective dose-escalation trials.

title: Evaluation of factors associated with loco-regional failure and survival in limited XXXX @entity0 treated with chemoradiotherapy.

answer: @entity2


abstract: BACKGROUND: @entity3 ( @entity3 ) remains a significant problem in limited @entity2 (LD- @entity8 ) @entity0 treated with definitive chemoradiotherapy. Dose-escalation may be a way forward to reduce the failure rate. However, the risk of @entity1 rises with increasing doses. Knowledge on factors associated with @entity3 could aid the selection of @entity0 for more aggressive treatment. Therefore, the aim of this study is to evaluate factors correlated with @entity3 in a cohort of LD- @entity8 @entity0 treated with definitive chemoradiotherapy. Moreover, factors associated with improved survival were investigated. MATERIAL AND METHODS: We included 147 consecutive LD- @entity8 @entity0 treated from 2007 to 2013. Radiotherapy was delivered as either 45 Gy in 1.5-Gy fractions twice daily or 46-50 Gy in 2-Gy fractions once daily. Chemotherapy was @entity6 combined with either @entity7 or @entity4 given mainly concomitantly with radiotherapy. Pattern of first failure and survival were evaluated retrospectively. @entity9 ( @entity9 ) and @entity5 ( @entity5 ) were calculated by the Kaplan-Meier method. The impact of covariates on @entity3 and @entity5 was evaluated by using Cox proportional hazards model. RESULTS: With a median follow-up time of 42.2 months, 37 @entity0 experienced @entity3 as first failure. Isolated @entity3 was seen in 16 @entity0 , but no isolated regional failure was seen. The @entity9 rate was 22% at 1-year and 43% at 3-years. N3-stage was an independent prognostic factor correlated with @entity3 development (p = 0.043). Median @entity5 was 24.1 months (95% CI 19-29 months) and a three-year survival of 34%. Prognostic factors associated with improved @entity5 were staging including a positron emission tomography (PET) scan (p = 0.004) and receiving prophylactic cranial irradiation (PCI) (p = 0.006). CONCLUSION: N3-stage was an independent prognostic factor for @entity3 . Receiving a pretreatment PET scan and receiving PCI were prognostic factors for improved @entity5 . Reduction in @entity3 may be achieved with dose-escalation in @entity0 with N3-stage. This can be evaluated in prospective dose-escalation trials.

title: Evaluation of factors associated with loco-regional failure and survival in limited @entity2 XXXX treated with chemoradiotherapy.

answer: @entity0


abstract: BACKGROUND: Whether a coronary artery @entity1 (CAC) scan provides added value to coronary computed tomographic angiography (CCTA) in emergency department @entity0 with acute @entity2 remains unsettled. We sought to determine the value of CAC scan in @entity0 with acute @entity2 undergoing CCTA. METHODS AND RESULTS: In the multicenter Rule Out Myocardial Infarction using Computer-Assisted Tomography (ROMICAT) II trial, we enrolled low-intermediate risk emergency department @entity0 with symptoms suggesting @entity3 ( @entity3 ). In this prespecified subanalysis of 473 @entity0 (54  8 years, 53% @entity0 ) who underwent both CAC scanning and CCTA, the @entity3 rate was 8%. Overall, 53% of @entity0 had CAC=0 of whom 2 (0.8%) developed @entity3 , whereas 7% had CAC>400 with 49% whom developed @entity3 . C-statistic of CAC>0 was 0.76, whereas that using the optimal cut point of CAC>= 22 was 0.81. Continuous CAC score had lower discriminatory capacity than CCTA (c-statistic, 0.86 versus 0.92; P=0.03). Compared with CCTA alone, there was no benefit combining CAC score with CCTA (c-statistic, 0.93; P=0.88) or with selective CCTA strategies after initial CAC>0 or optimal cut point CAC>= 22 (P>= 0.09). Mean radiation dose from CAC acquisition was 1.4  0.7 @entity4 . Higher CAC scores resulted in more nondiagnostic CCTA studies although the majority remained interpretable. CONCLUSIONS: In emergency department @entity0 with acute @entity2 , CAC score does not provide incremental value beyond CCTA for @entity3 diagnosis. CAC=0 does not exclude @entity3 , nor a high CAC score preclude interpretation of CCTA in most @entity0 . Thus, CAC results should not influence the decision to proceed with CCTA, and the decision to perform a CAC scan should be balanced with the additional radiation exposure required. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT01084239.

title: Use of Coronary Artery XXXX Scanning Beyond Coronary Computed Tomographic Angiography in the Emergency Department Evaluation for Acute @entity2 : The ROMICAT II Trial.

answer: @entity1


abstract: BACKGROUND: Whether a coronary artery @entity1 (CAC) scan provides added value to coronary computed tomographic angiography (CCTA) in emergency department @entity0 with acute @entity2 remains unsettled. We sought to determine the value of CAC scan in @entity0 with acute @entity2 undergoing CCTA. METHODS AND RESULTS: In the multicenter Rule Out Myocardial Infarction using Computer-Assisted Tomography (ROMICAT) II trial, we enrolled low-intermediate risk emergency department @entity0 with symptoms suggesting @entity3 ( @entity3 ). In this prespecified subanalysis of 473 @entity0 (54  8 years, 53% @entity0 ) who underwent both CAC scanning and CCTA, the @entity3 rate was 8%. Overall, 53% of @entity0 had CAC=0 of whom 2 (0.8%) developed @entity3 , whereas 7% had CAC>400 with 49% whom developed @entity3 . C-statistic of CAC>0 was 0.76, whereas that using the optimal cut point of CAC>= 22 was 0.81. Continuous CAC score had lower discriminatory capacity than CCTA (c-statistic, 0.86 versus 0.92; P=0.03). Compared with CCTA alone, there was no benefit combining CAC score with CCTA (c-statistic, 0.93; P=0.88) or with selective CCTA strategies after initial CAC>0 or optimal cut point CAC>= 22 (P>= 0.09). Mean radiation dose from CAC acquisition was 1.4  0.7 @entity4 . Higher CAC scores resulted in more nondiagnostic CCTA studies although the majority remained interpretable. CONCLUSIONS: In emergency department @entity0 with acute @entity2 , CAC score does not provide incremental value beyond CCTA for @entity3 diagnosis. CAC=0 does not exclude @entity3 , nor a high CAC score preclude interpretation of CCTA in most @entity0 . Thus, CAC results should not influence the decision to proceed with CCTA, and the decision to perform a CAC scan should be balanced with the additional radiation exposure required. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT01084239.

title: Use of Coronary Artery @entity1 Scanning Beyond Coronary Computed Tomographic Angiography in the Emergency Department Evaluation for Acute XXXX : The ROMICAT II Trial.

answer: @entity2


abstract: PURPOSE OF THE REPORT: @entity3 's incidence is increasing. We studied the efficacy of Y selective internal radiation therapy (SIRT) as first-line treatment, with chemotherapy, and compared with the results of chemotherapy alone. @entity0 AND METHODS: We retrospectively studied data from @entity0 treated at our institution with glass microspheres SIRT for @entity3 as part of first-line treatment in combination with chemotherapy. We compared results with those of similar @entity0 treated in the ABC-02 study (a study in advanced @entity2 that defined the current standard chemotherapy), assessed as not progressing after the first evaluation. We assessed progression-free survival (PFS) and overall survival (OS). RESULTS: Twenty-four @entity0 were treated with SIRT. Chemotherapy was given concomitantly in 10 (42%), as induction before SIRT in 13 (54%) or after SIRT in 1 (4%). Grade 3 adverse events were reported in 1 (4%). Median PFS after SIRT was 10.3 months. Longer PFS was observed when chemotherapy was given concomitantly than when chemotherapy was given before SIRT, with respective median of 20.0 versus 8.8 months (P = 0.001). Median OS after SIRT was not reached. Eleven @entity0 went to surgery (46%). Thirty-three @entity0 in ABC-02 had locally advanced nonextrahepatic @entity1 , not progressing after first evaluation. From the start of any treatment, the median PFS was 16.0 months in our cohort versus 11.3 months in ABC-02 (P = 0.25), whereas the median OS was significantly higher in our cohort, not reached versus 17.9 months, respectively (P = 0.026). CONCLUSIONS: Selective internal radiation therapy combined with concomitant chemotherapy seems a promising strategy as first-line treatment for unresectable @entity3 .

title: Glass Microspheres 90Y Selective Internal Radiation Therapy and Chemotherapy as First-Line Treatment of XXXX .

answer: @entity3


abstract: UNASSIGNED: The @entity3 chorioallantoic membrane (CAM) model has been successfully used to study angiogenesis, @entity2 progression and its pharmacological treatment, @entity2 pharmacokinetics, and properties of novel nanomaterials. MRI is an attractive technique for non-invasive and longitudinal monitoring of physiological processes and @entity2 growth. This study proposes an age-adapted cooling regime for immobilization of the @entity3 embryo, enabling high-resolution MRI of the embryo and the @entity2 xenograft. 64 @entity3 embryos were enrolled in this study. The novel immobilization and imaging protocol was optimized in 29 embryos. From d7 to d18 immobilization of the embryo up to 90   min was achieved by cooling at 4     C pre-imaging, with cooling times adapted to age. Its application to @entity2 growth monitoring was evaluated in 15 embryos after xenotransplantation of @entity1 MDA-MB-231 @entity0 cells on CAM. @entity2 volumes were monitored from d4 to d9 after grafting (d11 to d16 after incubation) applying a T2 -weighted multislice RARE sequence. At d9 after grafting, the @entity2 were collected and compared with the MRI-derived data by histology and weight measurements. Additional imaging methods comprising DWI, T2 mapping, and the bio-distribution of contrast agents were tested at d9 after grafting in 20 further embryos. With the adaptive cooling regime, motion artifacts could be completely avoided for up to 90   min scan time, enabling high-resolution in ovo imaging. Excellent anatomical details could be obtained in the embryo and @entity2 . @entity2 volumes could be quantified over time. The results prove the feasibility of high-resolution MRI for @entity2 and organ growth monitoring. The suggested method is promising for future applications such as testing tailored and/or targeted treatment strategies, longitudinal monitoring of @entity2 development, analysis of therapeutic efficacies of drugs, or assessment of @entity2 pharmacokinetics. The method provides an alternative to animal experimentation. Copyright    2015 John Wiley _ Sons, Ltd.

title: High-resolution MRI analysis of XXXX xenograft on the @entity3 chorioallantoic membrane.

answer: @entity0


abstract: UNASSIGNED: The @entity3 chorioallantoic membrane (CAM) model has been successfully used to study angiogenesis, @entity2 progression and its pharmacological treatment, @entity2 pharmacokinetics, and properties of novel nanomaterials. MRI is an attractive technique for non-invasive and longitudinal monitoring of physiological processes and @entity2 growth. This study proposes an age-adapted cooling regime for immobilization of the @entity3 embryo, enabling high-resolution MRI of the embryo and the @entity2 xenograft. 64 @entity3 embryos were enrolled in this study. The novel immobilization and imaging protocol was optimized in 29 embryos. From d7 to d18 immobilization of the embryo up to 90   min was achieved by cooling at 4     C pre-imaging, with cooling times adapted to age. Its application to @entity2 growth monitoring was evaluated in 15 embryos after xenotransplantation of @entity1 MDA-MB-231 @entity0 cells on CAM. @entity2 volumes were monitored from d4 to d9 after grafting (d11 to d16 after incubation) applying a T2 -weighted multislice RARE sequence. At d9 after grafting, the @entity2 were collected and compared with the MRI-derived data by histology and weight measurements. Additional imaging methods comprising DWI, T2 mapping, and the bio-distribution of contrast agents were tested at d9 after grafting in 20 further embryos. With the adaptive cooling regime, motion artifacts could be completely avoided for up to 90   min scan time, enabling high-resolution in ovo imaging. Excellent anatomical details could be obtained in the embryo and @entity2 . @entity2 volumes could be quantified over time. The results prove the feasibility of high-resolution MRI for @entity2 and organ growth monitoring. The suggested method is promising for future applications such as testing tailored and/or targeted treatment strategies, longitudinal monitoring of @entity2 development, analysis of therapeutic efficacies of drugs, or assessment of @entity2 pharmacokinetics. The method provides an alternative to animal experimentation. Copyright    2015 John Wiley _ Sons, Ltd.

title: High-resolution MRI analysis of @entity0 xenograft on the XXXX chorioallantoic membrane.

answer: @entity3


abstract: PURPOSE: Hyperthermic intraperitoneal chemotherapy (HIPEC) involves the continuous heating and circulation of chemotherapy throughout the abdominal cavity in an attempt to enhance @entity2 . Despite the potential of this chemotherapy procedure, there are scant anatomical temperature distribution studies reporting on this therapeutic process. @entity0 AND METHODS: We prospectively evaluated the temperature of select anatomical (e.g. upper abdominal, mid-abdominal and supra-pubic) sites in 11 advanced stage @entity1 @entity0 who were treated with consolidation HIPEC @entity3 (AUC 10). The temperature of the aforementioned anatomical regions and the inflow/outflow tubing was measured at baseline and at 15-min intervals until the procedure's completion. RESULTS: The lowest observed mean composite temperature was 41.1     C at the supra-pubic site whereas the highest temperature was 42.6     C, in association with the inflow/outflow tubing. During the various time intervals we also ascertained that the lowest composite temperature was 40.9     C at baseline (i.e. time 0), whereas the highest value (41.8     C) occurred at multiple time periods (e.g. 15, 45 and 60   min). CONCLUSION: The HIPEC temperature variation amongst the various abdominal sites and time intervals was minimal. We also discerned that uniform temperature distribution throughout the abdominal cavity was facilitated when the abdomen was both maximally distended with fluid and a high flow rate was maintained.

title: Intra-abdominal temperature distribution during consolidation hyperthermic intraperitoneal chemotherapy with XXXX in the treatment of @entity1 .

answer: @entity3


abstract: PURPOSE: Hyperthermic intraperitoneal chemotherapy (HIPEC) involves the continuous heating and circulation of chemotherapy throughout the abdominal cavity in an attempt to enhance @entity2 . Despite the potential of this chemotherapy procedure, there are scant anatomical temperature distribution studies reporting on this therapeutic process. @entity0 AND METHODS: We prospectively evaluated the temperature of select anatomical (e.g. upper abdominal, mid-abdominal and supra-pubic) sites in 11 advanced stage @entity1 @entity0 who were treated with consolidation HIPEC @entity3 (AUC 10). The temperature of the aforementioned anatomical regions and the inflow/outflow tubing was measured at baseline and at 15-min intervals until the procedure's completion. RESULTS: The lowest observed mean composite temperature was 41.1     C at the supra-pubic site whereas the highest temperature was 42.6     C, in association with the inflow/outflow tubing. During the various time intervals we also ascertained that the lowest composite temperature was 40.9     C at baseline (i.e. time 0), whereas the highest value (41.8     C) occurred at multiple time periods (e.g. 15, 45 and 60   min). CONCLUSION: The HIPEC temperature variation amongst the various abdominal sites and time intervals was minimal. We also discerned that uniform temperature distribution throughout the abdominal cavity was facilitated when the abdomen was both maximally distended with fluid and a high flow rate was maintained.

title: Intra-abdominal temperature distribution during consolidation hyperthermic intraperitoneal chemotherapy with @entity3 in the treatment of XXXX .

answer: @entity1


abstract: UNASSIGNED: Mild @entity2 with a reversible @entity2 ( @entity13 ) is a clinico-radiological syndrome characterized by a transient mild @entity2 and a reversible lesion in the splenium of the corpus callosum on MRI. This syndrome has almost universally been described in @entity0 from Japan and East Asia. Here we describe seven cases of @entity13 occurring in Caucasian Australian @entity0 from one centre seen over a 3 year period. All @entity0 had a fever-associated @entity2 (n  =  7), which presented with @entity6 (n  =  4), @entity3 (n  =  3), lethargy (n  =  3), slurred speech (n  =  3), drowsiness (n  =  2) and @entity7 (n  =  2). Other @entity1 included @entity9 (n  =  5) and @entity4 (n  =  1). These symptoms resolved rapidly over 4-6 days followed by complete neurological recovery. In all @entity0 , MRI performed within 1-3 days of onset of @entity2 demonstrated a symmetrical diffusion-restricted lesion in the splenium of the corpus callosum. Three @entity0 had additional lesions involving other parts of the corpus callosum and adjacent periventricular white matter. These same three @entity0 had mild persisting white matter changes evident at followup MRI, while the other @entity0 had complete resolution of radiological changes. A potential trigger was present in five of the seven cases: @entity5 , @entity12 , @entity11 , influenza B and adenovirus (all n  =  1). Elevated white cell count (n  =  4), elevated @entity8 (n  =  5) and @entity10 (n  =  6) were commonly observed. CSF was performed in four @entity0 , which showed no pleocytosis. This case series of @entity13 demonstrates this condition occurs outside of East Asia and is an important differential to consider in @entity0 presenting with acute @entity2 .

title: Mild @entity2 with reversible XXXX : An important differential of encephalitis.

answer: @entity2


abstract: UNASSIGNED: Mild @entity2 with a reversible @entity2 ( @entity13 ) is a clinico-radiological syndrome characterized by a transient mild @entity2 and a reversible lesion in the splenium of the corpus callosum on MRI. This syndrome has almost universally been described in @entity0 from Japan and East Asia. Here we describe seven cases of @entity13 occurring in Caucasian Australian @entity0 from one centre seen over a 3 year period. All @entity0 had a fever-associated @entity2 (n  =  7), which presented with @entity6 (n  =  4), @entity3 (n  =  3), lethargy (n  =  3), slurred speech (n  =  3), drowsiness (n  =  2) and @entity7 (n  =  2). Other @entity1 included @entity9 (n  =  5) and @entity4 (n  =  1). These symptoms resolved rapidly over 4-6 days followed by complete neurological recovery. In all @entity0 , MRI performed within 1-3 days of onset of @entity2 demonstrated a symmetrical diffusion-restricted lesion in the splenium of the corpus callosum. Three @entity0 had additional lesions involving other parts of the corpus callosum and adjacent periventricular white matter. These same three @entity0 had mild persisting white matter changes evident at followup MRI, while the other @entity0 had complete resolution of radiological changes. A potential trigger was present in five of the seven cases: @entity5 , @entity12 , @entity11 , influenza B and adenovirus (all n  =  1). Elevated white cell count (n  =  4), elevated @entity8 (n  =  5) and @entity10 (n  =  6) were commonly observed. CSF was performed in four @entity0 , which showed no pleocytosis. This case series of @entity13 demonstrates this condition occurs outside of East Asia and is an important differential to consider in @entity0 presenting with acute @entity2 .

title: Mild XXXX with reversible @entity2 : An important differential of encephalitis.

answer: @entity2


abstract: INTRODUCTION: Rupture of the ventricular septum complicates @entity3 in 0.2% of cases in the thrombolytic era. @entity4 ( @entity4 ) has a mortality of 90-95% in medically managed and 19-60% in surgically treated @entity0 . METHODS: A retrospective analysis was performed of 41 @entity0 , 26 females (63.4%) and 15 males (36.6%), average age 67.5    15 years, with post-infarction @entity4 who were treated in the VUL SK intensive cardiology unit between 1991 and 2007. RESULTS: Thirty-seven @entity0 had @entity1 (90.2%); anterior wall @entity3 ( @entity3 ) was found in 27 @entity0 (68%). @entity4 was more frequent in @entity0 than in @entity0 (p=0.043). In 36 @entity0 (87%) treatment was started 24 hours or later after the development of @entity3 symptoms. In 34 @entity0 (83%) the @entity2 occurred during the first episode of @entity3 and in the majority of these (19 @entity0 , 46.3%), preoperative coronary angiography demonstrated disease of only one coronary artery. During the first 10 days after the onset of @entity3 , 5 @entity0 (12.2%) were treated surgically but did not survive the operation; 33 @entity0 (80.5%) underwent operation 3-4 weeks after the onset of @entity3 and all survived. CONCLUSIONS: Female sex, advanced age, arterial @entity1 , anterior wall @entity3 , absence of previous @entity3 , and late arrival at hospital are associated with a higher risk of mortality from acute @entity4 . The most important factor that determines operative mortality and intra-hospital survival is the time from the onset of @entity3 to operation.

title: Post-infarction XXXX : risk factors and early outcomes.

answer: @entity4


abstract: Diminished insulin sensitivity in the peripheral tissues and failure of pancreatic beta cells to secrete insulin are known major determinants of @entity0 . @entity8 , an intestine-specific microsomal transfer protein inhibitor, has been shown to suppress high fat-induced @entity1 and ameliorate @entity6 while enhancing @entity7 ( @entity7 ) secretion. We investigated the effects of @entity8 on glucose metabolism and elucidated the mechanism of action, direct effects on insulin sensitivity and glucose-stimulated insulin secretion in a high fat diet-induced @entity1 @entity2 model. Male @entity2 fed a high-fat diet were treated with a single administration of @entity8 . Glucose tolerance, @entity4 clamp and hyperinsulinemic-euglycemic testing were performed to assess effects on insulin sensitivity and glucose-stimulated insulin secretion, respectively. Plasma @entity7 and tissue triglyceride content were also determined under the same conditions. A single administration of @entity8 suppressed plasma glucose elevations after oral glucose loading and increased the disposition index while elevating @entity7 . @entity8 also enhanced glucose-stimulated insulin secretion in @entity4 clamp tests, whereas @entity5 was observed in @entity3 . Single-dose administration of @entity8 decreased lipid content in the liver and skeletal muscle. @entity8 demonstrated acute and direct hypoglycemic effects by enhancing insulin secretion and/or insulin sensitivity.

title: Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of  microsomal triglyceride transfer protein (MTP) in XXXX @entity2 .

answer: @entity1


abstract: Diminished insulin sensitivity in the peripheral tissues and failure of pancreatic beta cells to secrete insulin are known major determinants of @entity0 . @entity8 , an intestine-specific microsomal transfer protein inhibitor, has been shown to suppress high fat-induced @entity1 and ameliorate @entity6 while enhancing @entity7 ( @entity7 ) secretion. We investigated the effects of @entity8 on glucose metabolism and elucidated the mechanism of action, direct effects on insulin sensitivity and glucose-stimulated insulin secretion in a high fat diet-induced @entity1 @entity2 model. Male @entity2 fed a high-fat diet were treated with a single administration of @entity8 . Glucose tolerance, @entity4 clamp and hyperinsulinemic-euglycemic testing were performed to assess effects on insulin sensitivity and glucose-stimulated insulin secretion, respectively. Plasma @entity7 and tissue triglyceride content were also determined under the same conditions. A single administration of @entity8 suppressed plasma glucose elevations after oral glucose loading and increased the disposition index while elevating @entity7 . @entity8 also enhanced glucose-stimulated insulin secretion in @entity4 clamp tests, whereas @entity5 was observed in @entity3 . Single-dose administration of @entity8 decreased lipid content in the liver and skeletal muscle. @entity8 demonstrated acute and direct hypoglycemic effects by enhancing insulin secretion and/or insulin sensitivity.

title: Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of  microsomal triglyceride transfer protein (MTP) in @entity1 XXXX .

answer: @entity2


abstract: AIM: Local excision of early @entity1 (ERCa) offers comparable survival and reduced operative morbidity compared with radical surgery yet it risks an adverse oncological outcome if performed in the wrong setting. This retrospective review considers the impact of the introduction of a specialist Early Rectal Cancer MDT (ERCaMDT) on the investigation and management of ERCa. METHOD: A retrospective comparative cohort study was undertaken. @entity0 with a final diagnosis of @entity3 @entity1 at our unit were identified for two 12-month periods before and after the introduction of the specialist ERCaMDT. Data on investigations and therapeutic interventions were compared. RESULTS: Nineteen @entity0 from 2006 and 24 from 2011 were included. In 2006, 12 @entity0 underwent @entity4 and four transrectal ultrasound (TRUS) examination while in 2011, 18 and 20 received @entity4 ( @entity4 ) and TRUS. In 2006 four @entity0 underwent incidental ERCa polypectomy with all having a positive resection margin leading to anterior resection. In 2011 only one case with a positive margin following extended EMR was identified. Definitive local excision without subsequent resection occurred in two @entity0 in 2006 and in 16 in 2011. CONCLUSION: The study demonstrates an improvement in pre-operative ERCa staging, a reduction in margin positivity and an increase in the use of local excision following the implementation of a specialist ERCa MDT. The increased detection of @entity2 through screening and surveillance programmes requires further investigation and management. A specialist ERCa MDT will improve management and should be available to all practioners involved with @entity0 with early @entity1 . This article is protected by copyright. All rights reserved.

title: The impact of a dedicated multidisciplinary team on the management of early XXXX .

answer: @entity1


abstract: UNASSIGNED: Although diagnosis is a central issue in medical care, in psychiatry its value is still controversial. The function of diagnosis is to indicate treatments and to help clinicians take better care of @entity0 . The fundamental role of diagnosis is to predict outcome and prognosis. To date serious concern persists regarding the clinical utility and predictive validity of the diagnosis system in psychiatry, which is at the most syndromal. @entity3 and @entity4 , which nosologists consider two distinct disorders, are the most discussed @entity2 illnesses. Recent findings in different fields of @entity2 research, such as neuroimaging, neuropathology, neuroimmunology, neuropsychology and genetics, have led to other conceptualizations. Individuals with @entity3 or @entity4 vary greatly with regard to symptoms, illness course, treatment response, @entity1 and biological correlates. In fact, it is possible to find heterogeneous correlates even within the same syndrome, i.e., from one stage of the disorder to another. Thus, it is possible to identify different subsyndromes, which share some clinical and neurobiological characteristics. The main goal of modern psychiatry is to ovethrow these barriers and to obtain a better understanding of the biological profiles underlying heterogeneous clinical features and thus reduce the variance and lead to a homogeneous definition. The translational research model, which connects the basic neuroscience research field with clinical experience in psychiatry, aims to investigate different neurobiological features of syndromes and of the shared neurobiological features between two syndromes. In fact, this approach should help us to better understand the neurobiological pathways underlying clinical entities, and even to distinguish different, more homogeneous, diagnostic subtypes.

title: @entity3 and XXXX : The road from similarities and clinical heterogeneity to neurobiological types.

answer: @entity4


abstract: UNASSIGNED: Although diagnosis is a central issue in medical care, in psychiatry its value is still controversial. The function of diagnosis is to indicate treatments and to help clinicians take better care of @entity0 . The fundamental role of diagnosis is to predict outcome and prognosis. To date serious concern persists regarding the clinical utility and predictive validity of the diagnosis system in psychiatry, which is at the most syndromal. @entity3 and @entity4 , which nosologists consider two distinct disorders, are the most discussed @entity2 illnesses. Recent findings in different fields of @entity2 research, such as neuroimaging, neuropathology, neuroimmunology, neuropsychology and genetics, have led to other conceptualizations. Individuals with @entity3 or @entity4 vary greatly with regard to symptoms, illness course, treatment response, @entity1 and biological correlates. In fact, it is possible to find heterogeneous correlates even within the same syndrome, i.e., from one stage of the disorder to another. Thus, it is possible to identify different subsyndromes, which share some clinical and neurobiological characteristics. The main goal of modern psychiatry is to ovethrow these barriers and to obtain a better understanding of the biological profiles underlying heterogeneous clinical features and thus reduce the variance and lead to a homogeneous definition. The translational research model, which connects the basic neuroscience research field with clinical experience in psychiatry, aims to investigate different neurobiological features of syndromes and of the shared neurobiological features between two syndromes. In fact, this approach should help us to better understand the neurobiological pathways underlying clinical entities, and even to distinguish different, more homogeneous, diagnostic subtypes.

title: XXXX and @entity4 : The road from similarities and clinical heterogeneity to neurobiological types.

answer: @entity3


abstract: BACKGROUND: Initial tissue sampling for diagnosis of suspected @entity3 ( @entity3 ) is typically performed using a shave biopsy technique or punch biopsy. METHODS: Our realization of no residual @entity3 findings after excision in some @entity0 with biopsy-proven @entity3 diagnosed through a shave biopsy prompted us to conduct a retrospective study of all consecutive @entity0 with 127 BCCs who were treated in our department between 2006 and 2012. All @entity0 with incompletely excised BCCs after shave biopsy diagnosis were operated on by a single surgeon (R.G.), eliminating variables in preoperative evaluation and surgical technique including margin control and reconstructive approach. @entity0 demographics, initial @entity3 site, size, subtype, duration between shave biopsy and surgery, size of excision, findings of intraoperative frozen section analysis, type of closure technique, and final pathology reports were analyzed. RESULTS: There were 108 residual BCCs diagnosed after surgical excision. Most of the108 BCCs were nodular (52) or micronodular (21) subtype. Eighteen BCCs were treated with excision and primary closure. Flap procedure was performed in 64 BCCs after excision. Twenty-six defects after excision were reconstructed using skin grafts. There was no evidence of residual @entity3 in 15% of BCCs (19 @entity0 ) after surgical treatment. In other words, shave biopsy was found to be curative in 15% of BCCs. Seven @entity0 in no residual @entity3 group received excision and primary closure. Eleven @entity0 underwent flap reconstruction, whereas only 1 @entity0 required skin grafting. Most of the @entity0 in this group had nodular or micronodular type @entity3 (14/19). CONCLUSIONS: We were not able to identify any clinically significant predictors of residual versus no residual @entity3 , at least within the context of the current study. Although most @entity0 diagnosed with @entity3 had @entity2 for which they received surgical treatment, 15% of @entity0 had to undergo primary closure, skin graft, or flap procedure for negative residual @entity3 . We would like to promote greater awareness on the subject among plastic surgeons treating BCCs. And, it is extremely important that the informed consent should include statements regarding possible reconstructive procedures even in the case of nonpersistent @entity1 from medicolegal standpoint.

title: Nonpersistence of XXXX After Diagnostic Shave Biopsy: Reconstruction When Specimen Is Negative During Surgery.

answer: @entity3


abstract: @entity7 ( @entity7 ) negative @entity0 are reported to occur rarely. We studied 14 @entity7 negative cases of @entity4 ( @entity4 ) detected during sentinel lymph node @entity2 work-up and immunohistochemistry panel in the work-up of metastatic @entity3 . Axillary lymph node @entity2 were present in seven @entity1 (50%). Oestrogen receptor (ER) was strongly positive in all cases: @entity8 in 78%, @entity5 in 7% and high proliferation index with Ki-67 >20% was seen in 71% of the cases. @entity2 and/or recurrence were found in 8 of 14 @entity1 (57%) with the mean clinical follow-up of 55   months. @entity2 sites include multiple bones, brain, spinal cord, liver, pancreas, ovary, lung, lymph node other than ipsilateral axillary and skin. 12 of 14 @entity1 received adjuvant chemotherapy. All 14 @entity1 received hormonal therapy and radiation therapy. Morphologically, @entity4 with neuroendocrine features was noted in 57%. @entity6 stain was positive in 57% and chromogranin was positive in 21% of the cases. In conclusion, these @entity7 negative @entity0 were ER positive, mostly @entity5 negative, had high Ki-67 and frequently showed neuroendocrine differentiation. More than half of these cases had a poor outcome.

title: @entity7 negative invasive XXXX : clinicopathological and immunohistochemical analysis of 14 cases with clinical follow-up.

answer: @entity0


abstract: @entity7 ( @entity7 ) negative @entity0 are reported to occur rarely. We studied 14 @entity7 negative cases of @entity4 ( @entity4 ) detected during sentinel lymph node @entity2 work-up and immunohistochemistry panel in the work-up of metastatic @entity3 . Axillary lymph node @entity2 were present in seven @entity1 (50%). Oestrogen receptor (ER) was strongly positive in all cases: @entity8 in 78%, @entity5 in 7% and high proliferation index with Ki-67 >20% was seen in 71% of the cases. @entity2 and/or recurrence were found in 8 of 14 @entity1 (57%) with the mean clinical follow-up of 55   months. @entity2 sites include multiple bones, brain, spinal cord, liver, pancreas, ovary, lung, lymph node other than ipsilateral axillary and skin. 12 of 14 @entity1 received adjuvant chemotherapy. All 14 @entity1 received hormonal therapy and radiation therapy. Morphologically, @entity4 with neuroendocrine features was noted in 57%. @entity6 stain was positive in 57% and chromogranin was positive in 21% of the cases. In conclusion, these @entity7 negative @entity0 were ER positive, mostly @entity5 negative, had high Ki-67 and frequently showed neuroendocrine differentiation. More than half of these cases had a poor outcome.

title: XXXX negative invasive @entity0 : clinicopathological and immunohistochemical analysis of 14 cases with clinical follow-up.

answer: @entity7


abstract: UNASSIGNED: @entity10 due to a @entity11 is rarely reported in the literature. @entity3 are @entity1 of the heart, most frequently located in the left atrium. @entity9 are rare. @entity9 attached to the anterior papillary muscle are especially rare, with only 1 case being reported in the literature. @entity11 have the potential to cause @entity6 , or @entity7 . We report a case of a 32-year-old @entity0 who sustained @entity8 and was found to have a left @entity2 attached to the anterior papillary muscle at autopsy. Although the subject also had evidence of a distant @entity5 and @entity4 , the @entity11 was apparently clinically silent. @entity3 may be treated by surgical excision with excellent prognosis. However, they can remain silent and undiagnosed and, hence, have the potential for causing @entity10 . In addition to the case report, we present a literature review of these issues involving @entity3 .

title: XXXX Causing @entity8 .

answer: @entity9


abstract: UNASSIGNED: @entity10 due to a @entity11 is rarely reported in the literature. @entity3 are @entity1 of the heart, most frequently located in the left atrium. @entity9 are rare. @entity9 attached to the anterior papillary muscle are especially rare, with only 1 case being reported in the literature. @entity11 have the potential to cause @entity6 , or @entity7 . We report a case of a 32-year-old @entity0 who sustained @entity8 and was found to have a left @entity2 attached to the anterior papillary muscle at autopsy. Although the subject also had evidence of a distant @entity5 and @entity4 , the @entity11 was apparently clinically silent. @entity3 may be treated by surgical excision with excellent prognosis. However, they can remain silent and undiagnosed and, hence, have the potential for causing @entity10 . In addition to the case report, we present a literature review of these issues involving @entity3 .

title: @entity9 Causing XXXX .

answer: @entity8


abstract: Despite the established role of @entity1 as a vector of various neurotropic viruses, such as the Rift Valley and West Nile viruses, as well as @entity2 , little is known regarding the organism's reproductive physiology. As in other oviparous animals, @entity3 , the most important source of nutrients for the embryo development, is digested by intracellular proteases. Using mass spectrometry, we have identified two @entity4 homologues partially purified by self-proteolysis of Cx. quinquefasciatus total egg extract. The transcriptional profile of these two @entity4 homologues was determined by quantitative RT-PCR, and the enzymatic activity associated with the peptidase was determined in ovaries after female engorgement. According to the VectorBase (vectorbase.org) annotation, both @entity4 homologues shared approximately 66% identity in their @entity0 sequences. The two @entity4 genes are expressed simultaneously in the fat body of the vitellogenic females, and enzymatic activity was detected within the ovaries, suggesting an extra-ovarian origin. Similar to the transcriptional profile of @entity3 , @entity4 transcripts were shown to accumulate post-blood meal and reached their highest expression at 36 h PBM. However, while @entity3 expression decreased drastically at 48 h PBM, the expression of the cathepsins increased until 84 h PBM, at which time the females of our colony were ready for oviposition. The similarity between their transcriptional profiles strongly suggests a role for the @entity4 homologues in vitellin degradation.

title: Two Cathepsins B Are Responsible for the Yolk Protein Hydrolysis in XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity2 are serious complications after hematopoietic stem cell transplantation (HSCT) and significantly contribute to morbidity and mortality. The purpose of this study was to investigate the clinical features and prognosis in pediatric @entity0 who had @entity2 after allogeneic HSCT. We retrospectively reviewed the medical records of @entity0 and adolescents (19 years old or younger) who underwent allogeneic HSCT at our institution from 2000 to 2012. A total of 383 @entity0 underwent 430 allogeneic transplantations. Among them, 73 episodes of @entity2 occurred in 70 @entity0 . The cumulative incidence of @entity2 at day 400 was 20.0%. Almost two thirds of the episodes (63.0%, 46 of 73) occurred within 100 days after transplantation. @entity8 -related @entity7 was observed as the most common cause of @entity7 (47.9%, 35 of 73) and was significantly associated with earlier onset @entity2 , @entity5 , and @entity4 . It also showed a significant association with lower probability of @entity1 , @entity3 , and neurologic sequelae. In a multivariate analysis, days to neutrophil engraftment after HSCT, extensive @entity6 ( @entity6 ) and the existence of neurologic sequelae were identified as risk factors for mortality in @entity0 who had @entity2 (hazard ratio [HR], 1.08; 95% confidence interval [CI], 1.02 to 1.15; P  = .011; HR, 5.98; 95% CI, 1.71 to 20.90; P  = .005; and HR, 4.37; 95% CI, 1.12 to 17.05; P  = .034, respectively). However, there was no significant difference in the 5-year overall survival between the @entity0 who had @entity2 without sequelae and the @entity0 who did not have any @entity2 (57.3% versus 61.8%, P  = .906). In conclusion, we found that the major significant risk factors for mortality in pediatric recipients with @entity2 were the existence of neurologic sequelae and extensive @entity6 .

title: Neurologic Complications after Allogeneic Hematopoietic Stem Cell Transplantation in XXXX : Analysis of Prognostic Factors.

answer: @entity0


abstract: PURPOSE: Distress and reduced quality of life (QOL) are common among @entity1 with @entity2 . No study has compared these variables after @entity0 to pre- @entity2 diagnosis levels. METHODS: Data on @entity1 with @entity0 50  years of age or older (n   =   6949) were analyzed from the @entity1 's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. @entity5 were measured with the six-item Center for Epidemiologic Studies @entity5 scale. Assessments occurred before and after the @entity2 diagnosis. @entity2 QOL and @entity5 to levels post-diagnosis and tested whether pre- @entity2 physical activity, stressful life events, @entity3 , and @entity4 predicted post-diagnosis outcomes. RESULTS: Compared with pre- @entity2 levels, @entity5 increased (20.0  % increase at 0-6  months, 12.9  % increase at 6-12  months), while physical function (-3.882 points at 0-6  months, -3.545 at 6-12  months) and mental health decreased (-2.899 points at 0-6  months, -1.672 at 6-12  months) in the first year after diagnosis (all p   <   .01). @entity5 returned to pre- @entity2 levels after 10  years, but QOL remained significantly lower. At more than 10  years post-diagnosis, physical function was 2.379 points lower than pre- @entity2 levels (p   <   0.01) while mental health was 1.922 points lower (p   <   0.01). All pre- @entity2 predictors were associated with all outcomes. @entity4 predicted uniquely greater decreases in physical function post-diagnosis. CONCLUSIONS: @entity5 increased and QOL decreased following @entity0 compared with pre- @entity2 levels, particularly in the first year. IMPLICATIONS FOR CANCER SURVIVORS: QOL may remain lower for years after @entity0 , although decreases are small.

title: XXXX and quality of life before and after @entity0 in older @entity1 from the @entity1 's Health Initiative.

answer: @entity5


abstract: PURPOSE: Distress and reduced quality of life (QOL) are common among @entity1 with @entity2 . No study has compared these variables after @entity0 to pre- @entity2 diagnosis levels. METHODS: Data on @entity1 with @entity0 50  years of age or older (n   =   6949) were analyzed from the @entity1 's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. @entity5 were measured with the six-item Center for Epidemiologic Studies @entity5 scale. Assessments occurred before and after the @entity2 diagnosis. @entity2 QOL and @entity5 to levels post-diagnosis and tested whether pre- @entity2 physical activity, stressful life events, @entity3 , and @entity4 predicted post-diagnosis outcomes. RESULTS: Compared with pre- @entity2 levels, @entity5 increased (20.0  % increase at 0-6  months, 12.9  % increase at 6-12  months), while physical function (-3.882 points at 0-6  months, -3.545 at 6-12  months) and mental health decreased (-2.899 points at 0-6  months, -1.672 at 6-12  months) in the first year after diagnosis (all p   <   .01). @entity5 returned to pre- @entity2 levels after 10  years, but QOL remained significantly lower. At more than 10  years post-diagnosis, physical function was 2.379 points lower than pre- @entity2 levels (p   <   0.01) while mental health was 1.922 points lower (p   <   0.01). All pre- @entity2 predictors were associated with all outcomes. @entity4 predicted uniquely greater decreases in physical function post-diagnosis. CONCLUSIONS: @entity5 increased and QOL decreased following @entity0 compared with pre- @entity2 levels, particularly in the first year. IMPLICATIONS FOR CANCER SURVIVORS: QOL may remain lower for years after @entity0 , although decreases are small.

title: @entity5 and quality of life before and after XXXX in older @entity1 from the @entity1 's Health Initiative.

answer: @entity0


abstract: PURPOSE: Distress and reduced quality of life (QOL) are common among @entity1 with @entity2 . No study has compared these variables after @entity0 to pre- @entity2 diagnosis levels. METHODS: Data on @entity1 with @entity0 50  years of age or older (n   =   6949) were analyzed from the @entity1 's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. @entity5 were measured with the six-item Center for Epidemiologic Studies @entity5 scale. Assessments occurred before and after the @entity2 diagnosis. @entity2 QOL and @entity5 to levels post-diagnosis and tested whether pre- @entity2 physical activity, stressful life events, @entity3 , and @entity4 predicted post-diagnosis outcomes. RESULTS: Compared with pre- @entity2 levels, @entity5 increased (20.0  % increase at 0-6  months, 12.9  % increase at 6-12  months), while physical function (-3.882 points at 0-6  months, -3.545 at 6-12  months) and mental health decreased (-2.899 points at 0-6  months, -1.672 at 6-12  months) in the first year after diagnosis (all p   <   .01). @entity5 returned to pre- @entity2 levels after 10  years, but QOL remained significantly lower. At more than 10  years post-diagnosis, physical function was 2.379 points lower than pre- @entity2 levels (p   <   0.01) while mental health was 1.922 points lower (p   <   0.01). All pre- @entity2 predictors were associated with all outcomes. @entity4 predicted uniquely greater decreases in physical function post-diagnosis. CONCLUSIONS: @entity5 increased and QOL decreased following @entity0 compared with pre- @entity2 levels, particularly in the first year. IMPLICATIONS FOR CANCER SURVIVORS: QOL may remain lower for years after @entity0 , although decreases are small.

title: @entity5 and quality of life before and after @entity0 in older XXXX from the @entity1 's Health Initiative.

answer: @entity1


abstract: PURPOSE: Distress and reduced quality of life (QOL) are common among @entity1 with @entity2 . No study has compared these variables after @entity0 to pre- @entity2 diagnosis levels. METHODS: Data on @entity1 with @entity0 50  years of age or older (n   =   6949) were analyzed from the @entity1 's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. @entity5 were measured with the six-item Center for Epidemiologic Studies @entity5 scale. Assessments occurred before and after the @entity2 diagnosis. @entity2 QOL and @entity5 to levels post-diagnosis and tested whether pre- @entity2 physical activity, stressful life events, @entity3 , and @entity4 predicted post-diagnosis outcomes. RESULTS: Compared with pre- @entity2 levels, @entity5 increased (20.0  % increase at 0-6  months, 12.9  % increase at 6-12  months), while physical function (-3.882 points at 0-6  months, -3.545 at 6-12  months) and mental health decreased (-2.899 points at 0-6  months, -1.672 at 6-12  months) in the first year after diagnosis (all p   <   .01). @entity5 returned to pre- @entity2 levels after 10  years, but QOL remained significantly lower. At more than 10  years post-diagnosis, physical function was 2.379 points lower than pre- @entity2 levels (p   <   0.01) while mental health was 1.922 points lower (p   <   0.01). All pre- @entity2 predictors were associated with all outcomes. @entity4 predicted uniquely greater decreases in physical function post-diagnosis. CONCLUSIONS: @entity5 increased and QOL decreased following @entity0 compared with pre- @entity2 levels, particularly in the first year. IMPLICATIONS FOR CANCER SURVIVORS: QOL may remain lower for years after @entity0 , although decreases are small.

title: @entity5 and quality of life before and after @entity0 in older @entity1 from the XXXX 's Health Initiative.

answer: @entity1


abstract: Extensive evidence exists regarding the efficacy and acceptability of medical abortion through 63 days since last menstrual period (LMP). In Mexico City's Secretariat of Health (SSDF) outpatient facilities, @entity2 - @entity1 medical abortion is the first-line approach for abortion care in this pregnancy range. Recent research demonstrates continued high rates of complete abortion through 70 days LMP. To expand access to legal abortion services in Mexico City (where abortion is legal through 12 weeks LMP), this study sought to assess the efficacy and acceptability of the standard outpatient approach through 70 days in two SSDF points of service. One thousand and one @entity0 seeking pregnancy termination were enrolled and given 200 mg @entity2 followed by 800  g @entity1 24-48 hours later. @entity0 were asked to return to the clinic one week later for evaluation. The great majority of @entity0 (93.3%; 95% CI: 91.6-94.8) had complete abortions. @entity0 with pregnancies  <=8 weeks LMP had significantly higher success rates than @entity0 in the 9th or 10th weeks (94.9% vs. 90.5%; p = 0.01). The difference in success rates between the 9th and 10th weeks was not significant (90.0% vs. 91.2%; p = 0.71). The majority of @entity0 found the side effects (82.9%) and the use of @entity1 (84.4%) to be very acceptable or acceptable. This study provides additional evidence supporting an extended outpatient medical abortion regimen through 10 weeks LMP.

title: Safety, efficacy and acceptability of outpatient XXXX - @entity1 medical abortion through 70 days since last menstrual period in public sector facilities in Mexico City.

answer: @entity2


abstract: Extensive evidence exists regarding the efficacy and acceptability of medical abortion through 63 days since last menstrual period (LMP). In Mexico City's Secretariat of Health (SSDF) outpatient facilities, @entity2 - @entity1 medical abortion is the first-line approach for abortion care in this pregnancy range. Recent research demonstrates continued high rates of complete abortion through 70 days LMP. To expand access to legal abortion services in Mexico City (where abortion is legal through 12 weeks LMP), this study sought to assess the efficacy and acceptability of the standard outpatient approach through 70 days in two SSDF points of service. One thousand and one @entity0 seeking pregnancy termination were enrolled and given 200 mg @entity2 followed by 800  g @entity1 24-48 hours later. @entity0 were asked to return to the clinic one week later for evaluation. The great majority of @entity0 (93.3%; 95% CI: 91.6-94.8) had complete abortions. @entity0 with pregnancies  <=8 weeks LMP had significantly higher success rates than @entity0 in the 9th or 10th weeks (94.9% vs. 90.5%; p = 0.01). The difference in success rates between the 9th and 10th weeks was not significant (90.0% vs. 91.2%; p = 0.71). The majority of @entity0 found the side effects (82.9%) and the use of @entity1 (84.4%) to be very acceptable or acceptable. This study provides additional evidence supporting an extended outpatient medical abortion regimen through 10 weeks LMP.

title: Safety, efficacy and acceptability of outpatient @entity2 - XXXX medical abortion through 70 days since last menstrual period in public sector facilities in Mexico City.

answer: @entity1


abstract: BACKGROUND: Infections downregulate cytochrome-P activities and thus may alter drug disposition, especially for drugs with a narrow therapeutic index. @entity1 ( @entity6 ), still used for the prevention of allograft rejection in renal transplant recipients in Egypt, seems to be affected by these infectious changes, based on random clinical observations. In the present study, the effects of @entity5 on @entity6 metabolism were studied in renal transplant @entity0 and subsequent nephrotoxicity was monitored. METHODS: Twenty renal transplant @entity0 , diagnosed with fungal or @entity5 , were recruited from the renal transplantation outpatient clinic in Alexandria University Hospitals. No dose adjustment in @entity6 was performed at least 1  week before the onset of @entity2 . Exclusion criteria were @entity0 with acute or chronic unstable @entity3 , elderly @entity0 , and @entity0 on concomitant drugs affecting @entity6 metabolism. @entity6 trough levels and serum @entity4 (SCR) concentrations were measured by fluorescence polarization immunoassay and enzymatic assay, respectively, pre- @entity2 , during @entity2 and in many cases, post @entity2 . RESULTS: @entity6 trough levels and SCR concentrations increased significantly during the @entity2 (P  <  0.001, P  =  0.002) respectively. Of the @entity0 , 87% experienced a concomitant rise in @entity6 trough level and SCR concentrations. No significant difference between pre- @entity2 and post- @entity2 levels of @entity6 trough and SCR was found. CONCLUSIONS: @entity6 trough and SCR levels increased during @entity5 and returned to pre- @entity2 levels once the @entity2 was resolved. The data generated stress the importance of monitoring @entity6 levels during episodes of @entity2 . Our recommendations concerning @entity6 dose adjustment differ according to severity and duration of @entity2 .

title: Effect of active @entity2 on cytochrome P450-mediated metabolism of XXXX in renal transplant @entity0 .

answer: @entity1


abstract: BACKGROUND: Infections downregulate cytochrome-P activities and thus may alter drug disposition, especially for drugs with a narrow therapeutic index. @entity1 ( @entity6 ), still used for the prevention of allograft rejection in renal transplant recipients in Egypt, seems to be affected by these infectious changes, based on random clinical observations. In the present study, the effects of @entity5 on @entity6 metabolism were studied in renal transplant @entity0 and subsequent nephrotoxicity was monitored. METHODS: Twenty renal transplant @entity0 , diagnosed with fungal or @entity5 , were recruited from the renal transplantation outpatient clinic in Alexandria University Hospitals. No dose adjustment in @entity6 was performed at least 1  week before the onset of @entity2 . Exclusion criteria were @entity0 with acute or chronic unstable @entity3 , elderly @entity0 , and @entity0 on concomitant drugs affecting @entity6 metabolism. @entity6 trough levels and serum @entity4 (SCR) concentrations were measured by fluorescence polarization immunoassay and enzymatic assay, respectively, pre- @entity2 , during @entity2 and in many cases, post @entity2 . RESULTS: @entity6 trough levels and SCR concentrations increased significantly during the @entity2 (P  <  0.001, P  =  0.002) respectively. Of the @entity0 , 87% experienced a concomitant rise in @entity6 trough level and SCR concentrations. No significant difference between pre- @entity2 and post- @entity2 levels of @entity6 trough and SCR was found. CONCLUSIONS: @entity6 trough and SCR levels increased during @entity5 and returned to pre- @entity2 levels once the @entity2 was resolved. The data generated stress the importance of monitoring @entity6 levels during episodes of @entity2 . Our recommendations concerning @entity6 dose adjustment differ according to severity and duration of @entity2 .

title: Effect of active XXXX on cytochrome P450-mediated metabolism of @entity1 in renal transplant @entity0 .

answer: @entity2


abstract: BACKGROUND: Infections downregulate cytochrome-P activities and thus may alter drug disposition, especially for drugs with a narrow therapeutic index. @entity1 ( @entity6 ), still used for the prevention of allograft rejection in renal transplant recipients in Egypt, seems to be affected by these infectious changes, based on random clinical observations. In the present study, the effects of @entity5 on @entity6 metabolism were studied in renal transplant @entity0 and subsequent nephrotoxicity was monitored. METHODS: Twenty renal transplant @entity0 , diagnosed with fungal or @entity5 , were recruited from the renal transplantation outpatient clinic in Alexandria University Hospitals. No dose adjustment in @entity6 was performed at least 1  week before the onset of @entity2 . Exclusion criteria were @entity0 with acute or chronic unstable @entity3 , elderly @entity0 , and @entity0 on concomitant drugs affecting @entity6 metabolism. @entity6 trough levels and serum @entity4 (SCR) concentrations were measured by fluorescence polarization immunoassay and enzymatic assay, respectively, pre- @entity2 , during @entity2 and in many cases, post @entity2 . RESULTS: @entity6 trough levels and SCR concentrations increased significantly during the @entity2 (P  <  0.001, P  =  0.002) respectively. Of the @entity0 , 87% experienced a concomitant rise in @entity6 trough level and SCR concentrations. No significant difference between pre- @entity2 and post- @entity2 levels of @entity6 trough and SCR was found. CONCLUSIONS: @entity6 trough and SCR levels increased during @entity5 and returned to pre- @entity2 levels once the @entity2 was resolved. The data generated stress the importance of monitoring @entity6 levels during episodes of @entity2 . Our recommendations concerning @entity6 dose adjustment differ according to severity and duration of @entity2 .

title: Effect of active @entity2 on cytochrome P450-mediated metabolism of @entity1 in renal transplant XXXX .

answer: @entity0


abstract: BACKGROUND: Preoperative @entity2 aggressiveness biomarkers may help surgeons decide the extent of an operation. However, whether serum angiogenetic factors can be used to predict the prognosis of @entity0 with differentiated @entity4 is still unclear. METHODS: Seventy-six DTC @entity0 were prospectively recruited. Preoperative serum samples were collected and measured for @entity6 , @entity7 , @entity5 , @entity3 , and @entity8 levels. The potential correlations between their serum levels and clinicopathologic features as well as their prognoses were analyzed. RESULTS: Older age (>45 years old) and higher @entity3 serum levels were independent predictors of extrathyroidal extension. The @entity8 serum level was an independent factor for lymph node @entity1 and @entity3 was an independent factor for distant @entity1 . None of these serum angiogenetic factors were significantly different between @entity0 who were disease free and those with recurrences. The presence of lymph node @entity1 was the only independent factor for recurrence over the 2-year follow-up. CONCLUSION: Preoperative serum @entity3 and @entity8 levels were significantly elevated in DTC @entity0 with distant and lymph node @entity1 . These findings, when combined with other clinicopathological factors, may help in surgical decisions.

title: @entity8 and A Preoperative Serum Levels Predict Nodal and Distant @entity1 in Differentiated XXXX @entity0 .

answer: @entity4


abstract: BACKGROUND: Preoperative @entity2 aggressiveness biomarkers may help surgeons decide the extent of an operation. However, whether serum angiogenetic factors can be used to predict the prognosis of @entity0 with differentiated @entity4 is still unclear. METHODS: Seventy-six DTC @entity0 were prospectively recruited. Preoperative serum samples were collected and measured for @entity6 , @entity7 , @entity5 , @entity3 , and @entity8 levels. The potential correlations between their serum levels and clinicopathologic features as well as their prognoses were analyzed. RESULTS: Older age (>45 years old) and higher @entity3 serum levels were independent predictors of extrathyroidal extension. The @entity8 serum level was an independent factor for lymph node @entity1 and @entity3 was an independent factor for distant @entity1 . None of these serum angiogenetic factors were significantly different between @entity0 who were disease free and those with recurrences. The presence of lymph node @entity1 was the only independent factor for recurrence over the 2-year follow-up. CONCLUSION: Preoperative serum @entity3 and @entity8 levels were significantly elevated in DTC @entity0 with distant and lymph node @entity1 . These findings, when combined with other clinicopathological factors, may help in surgical decisions.

title: @entity8 and A Preoperative Serum Levels Predict Nodal and Distant XXXX in Differentiated @entity4 @entity0 .

answer: @entity1


abstract: BACKGROUND: Preoperative @entity2 aggressiveness biomarkers may help surgeons decide the extent of an operation. However, whether serum angiogenetic factors can be used to predict the prognosis of @entity0 with differentiated @entity4 is still unclear. METHODS: Seventy-six DTC @entity0 were prospectively recruited. Preoperative serum samples were collected and measured for @entity6 , @entity7 , @entity5 , @entity3 , and @entity8 levels. The potential correlations between their serum levels and clinicopathologic features as well as their prognoses were analyzed. RESULTS: Older age (>45 years old) and higher @entity3 serum levels were independent predictors of extrathyroidal extension. The @entity8 serum level was an independent factor for lymph node @entity1 and @entity3 was an independent factor for distant @entity1 . None of these serum angiogenetic factors were significantly different between @entity0 who were disease free and those with recurrences. The presence of lymph node @entity1 was the only independent factor for recurrence over the 2-year follow-up. CONCLUSION: Preoperative serum @entity3 and @entity8 levels were significantly elevated in DTC @entity0 with distant and lymph node @entity1 . These findings, when combined with other clinicopathological factors, may help in surgical decisions.

title: XXXX and A Preoperative Serum Levels Predict Nodal and Distant @entity1 in Differentiated @entity4 @entity0 .

answer: @entity8


abstract: BACKGROUND: Preoperative @entity2 aggressiveness biomarkers may help surgeons decide the extent of an operation. However, whether serum angiogenetic factors can be used to predict the prognosis of @entity0 with differentiated @entity4 is still unclear. METHODS: Seventy-six DTC @entity0 were prospectively recruited. Preoperative serum samples were collected and measured for @entity6 , @entity7 , @entity5 , @entity3 , and @entity8 levels. The potential correlations between their serum levels and clinicopathologic features as well as their prognoses were analyzed. RESULTS: Older age (>45 years old) and higher @entity3 serum levels were independent predictors of extrathyroidal extension. The @entity8 serum level was an independent factor for lymph node @entity1 and @entity3 was an independent factor for distant @entity1 . None of these serum angiogenetic factors were significantly different between @entity0 who were disease free and those with recurrences. The presence of lymph node @entity1 was the only independent factor for recurrence over the 2-year follow-up. CONCLUSION: Preoperative serum @entity3 and @entity8 levels were significantly elevated in DTC @entity0 with distant and lymph node @entity1 . These findings, when combined with other clinicopathological factors, may help in surgical decisions.

title: @entity8 and A Preoperative Serum Levels Predict Nodal and Distant @entity1 in Differentiated @entity4 XXXX .

answer: @entity0


abstract: Normal blood flow patterns were characterized in individual CD @entity0 , nonpregnant (NP) or on day 6, 7, 8, 10, 11, 12, 13, 16, 18, or 20 of gestation using the radioactive microsphere technique. Five animals were evaluated at each stage of pregnancy. Weights and flow values were determined for several maternal organs and uterine tissue samples. Embryo/fetal (E/F) sex was determined from day 11 on by measuring the prevalence of nuclei with sex chromatin in amnion smears. There was a marked increase in absolute flow to the uterus and all uterine contents during gestation (0.28 +/- 0.13 ml/min to the NP, diestrous uterus; 9.07 +/- 0.97 ml/min on day 20 of pregnancy). However, relative blood flow (ml/min/g tissue) decreased by day 20 to one-third NP values. Thus, though blood flow greatly increased, it did so at a rate lower than total tissue growth (including the uterus, placental tissues, and the E/F itself). There was a rapid redistribution of blood flow from the decidua parietalis (DEC) to the @entity1 ( @entity1 ) on days 11-13, with nearly equal flow being delivered to the @entity1 and DEC of the "average" embryo on day 12 of gestation. By day 16 the DEC functionally had atrophied, and nearly 100% of the flow was delivered to the @entity1 . Male E/Fs tended to weigh more than female; however, these differences were statistically significant only on days 13, 18, and 20. E/F sex was not found to be strongly related to any of the variables evaluated in this study except E/F weight. Significant interlitter variability in E/F weight and blood flow consistently was observed at all gestational stages. Differences in litter size and E/F distribution within the two uterine horns did not account for the majority of this variability.

title: Blood flow during pregnancy in the XXXX : II. Dynamics of and litter variability in uterine flow.

answer: @entity0


abstract: OBJECTIVE: @entity3 is common in @entity1 ( @entity1 ). We aimed to update the incidence of severe and symptomatic @entity3 and investigate several correlated factors. METHODS: In this multicenter, observational retrospective study, the data of 206 @entity1 @entity0 from a sample of 2,229 consecutive @entity0 seen at 18 @entity1 clinics were analyzed. Sociodemographic and clinical characteristics, severe @entity3 in the past 12  months, and symptomatic @entity3 in the past 4  weeks were recorded with a self-report questionnaire and a clinical form during a routine visit. Poisson multivariate models were applied. RESULTS: A minority of @entity0 accounted for the majority of both severe and symptomatic episodes. The incidence rate (IR) of severe @entity3 was 0.49 (0.40-0.60) events/ @entity0 -years. The incidence rate ratio (IRR) was higher in @entity0 with previous severe @entity3 (3.71; 2.28-6.04), @entity2 (4.16; 2.14-8.05), long duration (>20  years, 2.96; 1.60-5.45), and on polypharmacy (1.24; 1.13-1.36), but it was lower when a complication was present. The IR of symptomatic @entity3 was 53.3 events/ @entity0 -years, with an IRR significantly higher among @entity0 or @entity0 with better education, or shorter duration or on pumps. The IRR was lower in @entity0 with higher BMI or @entity2 or aged more than 50  years. CONCLUSIONS: Fewer than 20  % of @entity1 @entity0 are free from @entity3 , with one in six having experienced at least one severe episode in the last year. The distribution is uneven, with a tendency of episodes to cluster in some @entity0 . Severe and symptomatic episodes have different correlates and reflect different conditions.

title: Incidence and risk factors for severe and symptomatic @entity3 in type 1 XXXX . Results of the HYPOS-1 study.

answer: @entity1


abstract: OBJECTIVE: @entity3 is common in @entity1 ( @entity1 ). We aimed to update the incidence of severe and symptomatic @entity3 and investigate several correlated factors. METHODS: In this multicenter, observational retrospective study, the data of 206 @entity1 @entity0 from a sample of 2,229 consecutive @entity0 seen at 18 @entity1 clinics were analyzed. Sociodemographic and clinical characteristics, severe @entity3 in the past 12  months, and symptomatic @entity3 in the past 4  weeks were recorded with a self-report questionnaire and a clinical form during a routine visit. Poisson multivariate models were applied. RESULTS: A minority of @entity0 accounted for the majority of both severe and symptomatic episodes. The incidence rate (IR) of severe @entity3 was 0.49 (0.40-0.60) events/ @entity0 -years. The incidence rate ratio (IRR) was higher in @entity0 with previous severe @entity3 (3.71; 2.28-6.04), @entity2 (4.16; 2.14-8.05), long duration (>20  years, 2.96; 1.60-5.45), and on polypharmacy (1.24; 1.13-1.36), but it was lower when a complication was present. The IR of symptomatic @entity3 was 53.3 events/ @entity0 -years, with an IRR significantly higher among @entity0 or @entity0 with better education, or shorter duration or on pumps. The IRR was lower in @entity0 with higher BMI or @entity2 or aged more than 50  years. CONCLUSIONS: Fewer than 20  % of @entity1 @entity0 are free from @entity3 , with one in six having experienced at least one severe episode in the last year. The distribution is uneven, with a tendency of episodes to cluster in some @entity0 . Severe and symptomatic episodes have different correlates and reflect different conditions.

title: Incidence and risk factors for severe and symptomatic XXXX in type 1 @entity1 . Results of the HYPOS-1 study.

answer: @entity3


abstract: UNASSIGNED: Brucea javanica oil emulsion (BJOE), the petroleum ether extract of B. javanica emulsified by phospholipid, is widely used in China as an anticancer agent. The extracts from B. javanica induce @entity1 cell @entity2 by various mechanisms; however, it is not known whether these mechanisms involve autophagy, which is an important process in @entity1 development and treatment. Thus, the current study aimed to investigate whether BJOE modulates autophagy in HCT116 @entity0 @entity3 cells and whether modulation of autophagy is an anticancer mechanism of BJOE. Immunoblotting was employed to analyze the protein expression levels of microtubule-associated protein light-chain 3 ( @entity8 ), a specific protein marker of autophagy, in HCT116 @entity1 cells following exposure to BJOE. The apoptosis rate of the HCT116 @entity1 cells was detected by performing an @entity6 - @entity5 / @entity4 assay. According to the effect of BJOE administration on autophagy in the HCT116 @entity1 cells (induction or suppression), a functionally opposite agent (autophagy suppressor or inducer) was applied to counteract this effect, and the apoptosis rate of the @entity1 cells was detected again. The role of autophagy (pro-survival or pro- @entity2 ) was demonstrated by comparing the rates of apoptotic @entity1 cells prior to and following the counteraction. The results revealed that BJOE suppressed the protein expression levels of @entity8 , including the @entity8 -I and @entity8 -II forms, and induced apoptosis in the HCT116 @entity1 cells with a high level of basal @entity8 . The apoptosis-inducing activity of BJOE was significantly attenuated when autophagy was induced by the administration of @entity7 , an autophagy inducer. The data indicates that autophagy inhibition is involved in BJOE-induced @entity1 cell @entity2 , and that this inhibition may be a potential anticancer mechanism of BJOE.

title: Involvement of autophagy inhibition in Brucea javanica oil emulsion-induced XXXX cell @entity2 .

answer: @entity3


abstract: UNASSIGNED: Brucea javanica oil emulsion (BJOE), the petroleum ether extract of B. javanica emulsified by phospholipid, is widely used in China as an anticancer agent. The extracts from B. javanica induce @entity1 cell @entity2 by various mechanisms; however, it is not known whether these mechanisms involve autophagy, which is an important process in @entity1 development and treatment. Thus, the current study aimed to investigate whether BJOE modulates autophagy in HCT116 @entity0 @entity3 cells and whether modulation of autophagy is an anticancer mechanism of BJOE. Immunoblotting was employed to analyze the protein expression levels of microtubule-associated protein light-chain 3 ( @entity8 ), a specific protein marker of autophagy, in HCT116 @entity1 cells following exposure to BJOE. The apoptosis rate of the HCT116 @entity1 cells was detected by performing an @entity6 - @entity5 / @entity4 assay. According to the effect of BJOE administration on autophagy in the HCT116 @entity1 cells (induction or suppression), a functionally opposite agent (autophagy suppressor or inducer) was applied to counteract this effect, and the apoptosis rate of the @entity1 cells was detected again. The role of autophagy (pro-survival or pro- @entity2 ) was demonstrated by comparing the rates of apoptotic @entity1 cells prior to and following the counteraction. The results revealed that BJOE suppressed the protein expression levels of @entity8 , including the @entity8 -I and @entity8 -II forms, and induced apoptosis in the HCT116 @entity1 cells with a high level of basal @entity8 . The apoptosis-inducing activity of BJOE was significantly attenuated when autophagy was induced by the administration of @entity7 , an autophagy inducer. The data indicates that autophagy inhibition is involved in BJOE-induced @entity1 cell @entity2 , and that this inhibition may be a potential anticancer mechanism of BJOE.

title: Involvement of autophagy inhibition in Brucea javanica oil emulsion-induced @entity3 cell XXXX .

answer: @entity2


abstract: PURPOSE: To assess the prognostic value of the number of negative lymph nodes (NLNs) in @entity0 @entity1 with positive axillary lymph nodes after mastectomy and its predictive value for radiotherapy efficacy of different @entity0 subtypes (BCS). METHODS: The records of 1,260 @entity0 @entity1 with positive axillary lymph nodes who received mastectomy between January 1998 and December 2007 were reviewed. The prognostic impact and predictive value of the number of NLNs with respect to locoregional recurrence-free survival (LRFS), disease-free survival (DFS), and @entity2 ( @entity2 ) were analyzed. RESULTS: The median follow-up time was 58 months, and 444 @entity1 (35.2%) received postmastectomy radiotherapy (PMRT). Univariate and multivariate Cox survival analysis indicated the number of NLNs was an independent prognostic factor of LRFS, DFS, and @entity2 . @entity1 with a higher number of NLNs had better survival. PMRT improved the LRFS of @entity1 with  <= 8 NLNs ( p < 0.001), while failing to improve the LRFS of @entity1 with > 8 NLNs (p = 0.075). In @entity1 with luminal A subtype, PMRT improved the LRFS, DFS, and @entity2 of @entity1 with  <= 8 NLNs, but in @entity1 with > 8 NLNs only the LRFS was improved. For @entity1 with luminal B subtype, PMRT only improved the LRFS of @entity1 with  <= 8 NLNs. The number of NLNs had no predictive value for the efficacy with PMRT in Her2+ and triple-negative subtypes. CONCLUSIONS: The number of NLNs is a prognostic indicator in @entity1 with @entity0 , and it can predict the efficacy of PMRT according to different BCS.

title: Number of negative lymph nodes can predict survival after postmastectomy radiotherapy according to different XXXX subtypes.

answer: @entity0


abstract: PURPOSE: To assess the clinical value of FDG PET/CT and evaluate the complementary roles of serum squamous cell carcinoma antigen (SCCAg) and FDG PET/CT in the diagnosis of suspected recurrent of cervical @entity3 . METHODS: Serum SCCAg levels were retrospectively reviewed in @entity0 previously treated for @entity2 , who had suspected recurrence of cervical @entity1 and who had undergone FDG PET/CT scans. The clinical impact of elevated SCCAg (>1.5 ng/ml) and negative SCCAg ( <=1.5 ng/ml) levels were analyzed based on the results of PET/CT and final diagnosis. RESULTS: The overall @entity0 -based sensitivity, specificity, accuracy, positive predictive value ( @entity4 ) and negative predictive value (NPV) of PET/CT for the detection of @entity1 recurrence or @entity1 were 100% (86/86), 80.8% (21/26), 95.5% (107/112), 94.5% (86/91) and 100% (21/21), respectively. Of the 112 @entity0 included in this study, recurrence or @entity1 was detected by PET/CT in 62 of the 64 @entity0 with elevated SCCAg, compared to 24 of the 48 @entity0 with negative SCCAg levels. The overall @entity0 -based @entity4 , NPV, sensitivity and accuracy of SCCAg for the detection of @entity1 recurrence or @entity1 were 96.9% (62/64), 50% (24/48), 72.1% (62/86) and 76.8% (86/112), respectively. The five false-positive PET/CT results were all associated with @entity0 with negative SCCAg levels. The @entity4 of positive PET/CT-associated elevated SCCAg for the detection of @entity1 recurrence or @entity1 was 100% (62/62). The NPV of negative SCCAg-associated negative PET/CT was 100% (19/19). CONCLUSIONS: Serum SCCAg evaluation and FDG PET/CT imaging can be complementary techniques in cases of suspected recurrent cervical @entity1 . Positive PET/CT with elevated SCCAg can predict recurrence. Although PET/CT cannot confidently be deferred due to a negative SCCAg test, the possibility of a false-positive PET/CT in those cases may have diagnostic importance.

title: Complementary Roles of XXXX Antigen and (18)F-FDG PET/CT in Suspected Recurrence of @entity3 .

answer: @entity2


abstract: PURPOSE: To assess the clinical value of FDG PET/CT and evaluate the complementary roles of serum squamous cell carcinoma antigen (SCCAg) and FDG PET/CT in the diagnosis of suspected recurrent of cervical @entity3 . METHODS: Serum SCCAg levels were retrospectively reviewed in @entity0 previously treated for @entity2 , who had suspected recurrence of cervical @entity1 and who had undergone FDG PET/CT scans. The clinical impact of elevated SCCAg (>1.5 ng/ml) and negative SCCAg ( <=1.5 ng/ml) levels were analyzed based on the results of PET/CT and final diagnosis. RESULTS: The overall @entity0 -based sensitivity, specificity, accuracy, positive predictive value ( @entity4 ) and negative predictive value (NPV) of PET/CT for the detection of @entity1 recurrence or @entity1 were 100% (86/86), 80.8% (21/26), 95.5% (107/112), 94.5% (86/91) and 100% (21/21), respectively. Of the 112 @entity0 included in this study, recurrence or @entity1 was detected by PET/CT in 62 of the 64 @entity0 with elevated SCCAg, compared to 24 of the 48 @entity0 with negative SCCAg levels. The overall @entity0 -based @entity4 , NPV, sensitivity and accuracy of SCCAg for the detection of @entity1 recurrence or @entity1 were 96.9% (62/64), 50% (24/48), 72.1% (62/86) and 76.8% (86/112), respectively. The five false-positive PET/CT results were all associated with @entity0 with negative SCCAg levels. The @entity4 of positive PET/CT-associated elevated SCCAg for the detection of @entity1 recurrence or @entity1 was 100% (62/62). The NPV of negative SCCAg-associated negative PET/CT was 100% (19/19). CONCLUSIONS: Serum SCCAg evaluation and FDG PET/CT imaging can be complementary techniques in cases of suspected recurrent cervical @entity1 . Positive PET/CT with elevated SCCAg can predict recurrence. Although PET/CT cannot confidently be deferred due to a negative SCCAg test, the possibility of a false-positive PET/CT in those cases may have diagnostic importance.

title: Complementary Roles of @entity2 Antigen and (18)F-FDG PET/CT in Suspected Recurrence of XXXX .

answer: @entity3


abstract: The irreversible loss of cardiomyocytes remains a key problem to resolve, which forms the cellular basis of @entity1 . MSCs transplantation brings out a promising potential for myocardial renovation with less limitations. However, this cell transplantation therapy is limited by its poor viability after transplantation. Apoptosis is thought to be the major factor that affects the efficiency of MSCs transplantation. Therefore, exploring the process of apoptosis and the underlying mechanisms of MSCs in the 'harmful' microenvironment is significant for the sake of improving the efficiency of MSCs transplantation therapy. A @entity2 /reoxygenation (H/R) model of MSCs had been established. TUNEL, Hoechst staining and MTT were used for the evaluation of morphological changes, cell viability and apoptosis. Mitochondrial transmembrane potential was detected by JC-1 using the fluorescence microscopy system. The protein expression of @entity5 , @entity7 , p-AKT, @entity3 , @entity4 , p-JNK, @entity6 and @entity0 was assessed for the analysis of protein changes using the Western blot. In our study, H/R insult lead to apoptosis and cell viability lost in a time-dependent manner in MSCs. Multiple pathways were involved in the apoptosis of MSCs, including @entity5 released from mitochondria to cytosol, mitochondrial transmembrane potential lost. In addition, @entity7 and p-AKT were downregulated, while @entity3 , p-JNK and @entity0 were upregulated. H/R induced the apoptosis in MSCs is through multiple pathways. These multiple pathways will be helpful for understanding and explaining the process and mechanism of apoptosis in MSCs.

title: Apoptosis of bone marrow mesenchymal stem cells caused by XXXX /reoxygenation via multiple pathways.

answer: @entity2


abstract: Essential oil has performed a variety of indirect services used as insect/pest repellent. The present study investigated the acute and subchronic @entity2 of eucalyptus oil @entity3 ( @entity3 ). In addition, we conduct safety pharmacology evaluation of @entity3 to supplement the @entity2 tests and provide a basis for a comprehensive understanding of the @entity2 of @entity3 . Acute administration of @entity3 was done as single dose from 2772 mg to 5742 mg of @entity3 per kg/bodyweight (b.wt.) and subchronic @entity2 study for thirty days was done by daily oral administration of @entity3 at doses of 396, 792 and 1188 mg/kg b.wt. In SPF SD @entity1 . The acute @entity2 study showed the LD50 of @entity3 was 3811.5 mg/kg. The subchronic @entity2 study suggested the high-dose and middle-dose @entity3 slowed down the growth of male @entity1 . The clinical pathology showed the high-dose and middle-dose @entity3 could cause @entity0 . The safety pharmacology indicated that @entity3 had no side effects on @entity1 . These results suggest that @entity3 is a safe veterinary medicine for external use.

title: XXXX as well as evaluation of safety pharmacology of eucalyptus oil-water emulsions.

answer: @entity2


abstract: AIM: To investigate the characteristic of mature dendritic cell ( @entity13 ) and tolerogenic dendritic cell (TDC) in @entity0 lower limb @entity3 ( @entity3 ) and @entity1 foot and in vitro. METHODS: 58 @entity0 @entity3 and @entity1 foot arterial specimens were collected from surgical operation and autopsy. Immunohistochemical and Western blotting method were used to examine the distribution and the content of @entity11 and @entity10 positive reaction @entity13 and @entity12 and @entity13 -SIGN positive reaction TDC. Furthermore, bone marrow-derived DCs were induced by rmGM-CSF and rmIL-4 in the presence or absence of @entity4 in vitro. The percent of @entity8 (+) @entity12 (+)TDC and @entity8 (+) @entity11 (+) @entity13 were analyzed by flow cytometry. The effects of TDC and @entity13 on T lymphocytes were analyzed by the @entity9 level, the percent of Th17, and @entity9 mRNA expression. RESULTS: Immunogenicity @entity13 was heavily found in intima plaque and around the small vessel of adventitia on artherosclerosis aorta of lesion group, and was positively correlated to the progress of the disease. However, there were low expression of TDC and was negatively correlated to the progress of the disease. Meanwhile, we found that there is a close relationship between high glucose and disease progression. TDC expressed high levels of @entity5 and @entity7 and down-regulated the percent of @entity2 (+) @entity9 (+) Th17, @entity9 mRNA and the level of @entity9 in vitro. CONCLUSION: TDC and @entity13 are assembled in the process of @entity3 , and the progression of the disease might be aggravated by @entity13 -maturation. High glucose might closely relate to the progression of @entity6 .

title: Characteristics of immunogenic and tolerogenic dendritic cells within the arterial wall in XXXX and in vitro.

answer: @entity6


abstract: BACKGROUND: There is an increasing number of urgently ill and injured @entity0 being seen in @entity2 ( @entity2 ) of developing countries. The pediatric disease burden in EDs across Pakistan is generally unknown. Our main objective was to determine the spectrum of disease and injury among @entity0 seen in EDs in Pakistan through a nationwide @entity2 -based surveillance system. METHODS: Through the Pakistan National Emergency Department Surveillance (Pak-NEDS), data were collected from November 2010 to March 2011 in seven major tertiary care centers representing all provinces of Pakistan. These included five public and two private hospitals, with a collective annual census of over one million @entity2 encounters. RESULTS: Of 25,052 @entity0 registered in Pak-NEDS (10% of all @entity0 seen): 61% were male, 13% under 5 years, while almost 65% were between 10 to < 16 years. The majority (90%) were seen in public hospital EDs. About half the @entity0 were discharged from the EDs, 9% admitted to hospitals and only 1.3% died in the EDs. Injury (39%) was the most common presenting complaint, followed by @entity1 (19%) and @entity3 (18%). Injury was more likely in males vs. females (43% vs. 33%; p < 0.001), with a peak presentation in the 5-12 year age group (45%). CONCLUSIONS: Pediatric @entity0 constitute a smaller proportion among general @entity2 users in Pakistan. Injury is the most common presenting complaint for @entity0 seen in the @entity2 . These data will help in resource allocation for cost effective pediatric @entity2 service delivery systems. Prospective longer duration surveillance is needed in more representative pediatric EDs across Pakistan.

title: The pediatric disease spectrum in XXXX across Pakistan: data from a pilot surveillance system.

answer: @entity2