abstract: The aetiology of @entity7 ranges from food, insect venom, drugs and various chemicals. Some individuals do not develop @entity7 with the offending agent unless ingestion is related temporally to physical exertion, namely food dependent exercise induced @entity7 (FDEIA). The foods implicated are @entity8 , soya, peanut, milk and sea food. A retrospective study on @entity0 with FDEIA from two Allergy clinics in @entity9 Lanka from 2011 to 2015 is reported. @entity0 were selected who fulfilled the following criteria: clinical diagnosis of @entity7 according to the @entity4 ( @entity4 ) criteria, where the onset of symptoms was during exertion, within 4  h of ingesting a food, the ability to eat the implicated food independent of exercise, or exercise safely, if the food was not ingested in the preceding 4  h and an in vitro (ImmunoCap serum IgE to the food) or in vivo (skin prick test) test indicating evidence of sensitivity to the food. There were 19 @entity0 (12 males: 7 females). The ages ranged from 9 to 45 (mean 22.9, median 19  years). Eight @entity0 (42.1%) were in the 9-16 age group. Those below 16  years had a male:female ratio of 3:5, while for those above 16  years it was 9:2. @entity8 was the only food implicated in FDEIA in all @entity0 and was confirmed by skin prick testing, or by ImmunoCap specific IgE to @entity8 or     -  5 gliadin. All @entity0 had @entity1 , while 5/19 (26.3%) had @entity2 of the lips. Fifteen @entity0 (78.9%) had @entity5 of breath or wheezing, while 8 (42.1%) had lost consciousness. Nine @entity0 (47. 3%) had @entity3 . Fourteen (73.6%) of our @entity0 had severe reactions, with @entity6 or @entity3 , while 5 (26.3%) had symptoms related to the gastrointestinal tract. One @entity0 developed @entity7 on two occasions following inhalation of ganja, a local cannabis derivative along with the ingestion of @entity8 and exertion. @entity8 is the main food implicated in FDEIA in @entity9 Lanka. A local cannabis derivative, ganja has been implicated as a cofactor for the first time.

title: Food dependant exercise induced @entity7 a retrospective study from 2 XXXX clinics in Colombo, @entity9 Lanka.

answer: @entity4


abstract: UNASSIGNED: Adherent-invasive @entity4 (AIEC) are a group of isolates from the intestinal mucosa of @entity2 @entity0 that can invade intestinal epithelial cells (IECs) or macrophages and survive and/or replicate within. We have identified the ibeA gene in the genome of AIEC strain NRG857c and report now the contribution of IbeA to the interaction of AIEC with IECs, macrophages and colonization of the @entity1 intestine. An ibeA deletion mutant (  ibeA) was constructed and the in vitro effect on AIEC adhesion and invasion of non-polarized and polarized Caco-2 cells, adhesion and transcytosis of M-like cells, intracellular survival in @entity5 macrophages, and contribution to intestinal colonization of the @entity6 @entity1 model of @entity3 , was evaluated. A significant reduction in invasion was observed with the ibeA mutant in Caco-2 and M-like cells, while adhesion was not affected. Complementation of the mutant re-established Caco-2 invasive phenotype to wt levels. Reduction in invasion did not significantly affect transcytosis through M-like cells at early time points. The absence of ibeA significantly affected AIEC intra-macrophage survival up to 24 h post- @entity3 . No significant changes associated with IbeA were found in AIEC colonization across the @entity1 gastrointestinal tract, but a slight reduction of IFN-y was observed in the cecum of @entity1 infected with the ibeA mutant. Additionally, a decrease in the pathology scores was observed in the ileum and cecum of @entity1 infected with the ibeA mutant. Our data supports the function of IbeA in AIEC invasion process, macrophage survival and inflammatory response in the @entity1 intestine.

title: IbeA, the invasin of Adherent-Invasive XXXX (AIEC) mediates interaction with intestinal epithelia and macrophages.

answer: @entity4


abstract: UNASSIGNED: Mutations in the @entity6 and @entity4 genes confer an increased lifetime risk for @entity5 . @entity1 risk can be decreased by risk-reducing salpingo-oophorectomy (RRSO). Studies on RRSO material have altered the paradigm of serous @entity1 pathogenesis. The purpose of this study was to identify candidate genes possibly involved in the pathogenesis of serous @entity1 by carrying out a microarray analysis of differentially expressed genes in @entity7 - mutation positive @entity3 derived from RRSO surgery. Freshly frozen @entity3 samples from nine @entity6 /2 mutation carriers scheduled for RRSO were prospectively collected together with five mutation-negative control @entity0 undergoing salpingo-oophorectomy for benign indications. Microarray analysis of genome-wide gene expression was performed on @entity3 samples from the @entity7 and control @entity0 . The validation of microarray data was performed by quantitative real-time polymerase chain reaction (qRT-PCR) in selected cases of RRSO samples and also in high grade @entity2 samples collected from @entity0 with a BRCA phenotype. From 22,733 genes, 454 transcripts were identified that were differentially expressed in @entity6 /2 mutation carriers when compared with controls, pooling all @entity3 samples together. Of these, 299 genes were statistically significantly downregulated and 155 genes upregulated. Differentially expressed genes in @entity7 samples reported here might be involved @entity1 and provide interesting targets for further studies.    2015 Wiley Periodicals, Inc.

title: Microarray analysis of differentially expressed genes in XXXX from risk-reducing salpingo-oophorectomies.

answer: @entity3


abstract: OBJECTIVES: Computed tomography (CT) scans are routinely used for primary staging and disease surveillance in @entity0 with @entity1 . However, these scans have limited sensitivity in some organs and can only detect lesions with morphological changes, whereas @entity2 -positron emission tomography ( @entity2 -PET) scans are able to detect areas of metabolic change before morphological changes appear. The aim of this study was to evaluate the impact of @entity2 -PET/CT scans over conventional imaging during preoperative work-ups or follow-ups in a selected group of @entity0 . METHODS: This retrospective cohort study, which took place between July 2009 and May 2011, assessed 1,043 @entity0 records from the South East Scotland Cancer Network @entity1 database. A total of 102 @entity0 who underwent @entity2 -PET/CT scans in addition to conventional imaging were included in the study. These @entity0 had potentially resectable metastases, equivocal findings on CT scans and elevated carcinoembryonic antigen levels with negative conventional imaging. RESULTS: Of the 102 @entity0 included in the study, 22 underwent a preoperative @entity2 -PET/CT scan and 80 underwent a follow-up @entity2 -PET/CT scan. In the preoperative scan group, the @entity2 -PET/CT scan had a major impact on 16 @entity0 (72.75%) and no impact on six @entity0 (27.25%). In the follow-up scan group, the @entity2 -PET/CT scan had a major impact on 51 (63.75%), a minor impact on four (5%), no impact on 22 (27.5%) and a negative impact on three (3.75%) @entity0 . CONCLUSION: The results of this study demonstrated that @entity2 -PET/CT scans have a considerable effect on disease management when undertaken among indicated @entity1 @entity0 .

title: Selective Use of @entity2 -Positron Emission Tomography and Computed Tomography in the Management of Metastatic Disease from XXXX : Results from a regional centre.

answer: @entity1


abstract: OBJECTIVES: Computed tomography (CT) scans are routinely used for primary staging and disease surveillance in @entity0 with @entity1 . However, these scans have limited sensitivity in some organs and can only detect lesions with morphological changes, whereas @entity2 -positron emission tomography ( @entity2 -PET) scans are able to detect areas of metabolic change before morphological changes appear. The aim of this study was to evaluate the impact of @entity2 -PET/CT scans over conventional imaging during preoperative work-ups or follow-ups in a selected group of @entity0 . METHODS: This retrospective cohort study, which took place between July 2009 and May 2011, assessed 1,043 @entity0 records from the South East Scotland Cancer Network @entity1 database. A total of 102 @entity0 who underwent @entity2 -PET/CT scans in addition to conventional imaging were included in the study. These @entity0 had potentially resectable metastases, equivocal findings on CT scans and elevated carcinoembryonic antigen levels with negative conventional imaging. RESULTS: Of the 102 @entity0 included in the study, 22 underwent a preoperative @entity2 -PET/CT scan and 80 underwent a follow-up @entity2 -PET/CT scan. In the preoperative scan group, the @entity2 -PET/CT scan had a major impact on 16 @entity0 (72.75%) and no impact on six @entity0 (27.25%). In the follow-up scan group, the @entity2 -PET/CT scan had a major impact on 51 (63.75%), a minor impact on four (5%), no impact on 22 (27.5%) and a negative impact on three (3.75%) @entity0 . CONCLUSION: The results of this study demonstrated that @entity2 -PET/CT scans have a considerable effect on disease management when undertaken among indicated @entity1 @entity0 .

title: Selective Use of XXXX -Positron Emission Tomography and Computed Tomography in the Management of Metastatic Disease from @entity1 : Results from a regional centre.

answer: @entity2


abstract: OBJECTIVES: Screening for mutations in large genes is challenging in a molecular diagnostic environment. Sanger-based DNA sequencing methods are largely used; however, @entity1 ( @entity1 ) can accommodate increasing test demands and financial constraints. This study aimed to establish a simple workflow to amplify and screen all coding regions of the @entity3 and @entity2 ( @entity4 ) genes by Sanger-based sequencing as well as to assess a @entity1 approach encompassing multiplex polymerase chain reaction (PCR) and pyrosequencing. METHODS: This study was conducted between July 2011 and April 2013. A total of 20 @entity0 were included in the study who had been referred to Genetic Health Services New Zealand (Northern Hub) for @entity4 mutation screening. @entity0 were randomly divided into a @entity1 evaluation and validation cohort (n = 10 @entity0 each). Primers were designed to amplify all coding exons of @entity4 (28 and 42 primer pairs, respectively). Primers overlying known variants were avoided to circumvent allelic drop-out. The @entity1 approach necessitated utilisation of a complementary fragment analysis assay to eliminate apparent false-positives at homopolymeric regions. Variants were filtered on the basis of their frequency and sequence depth. RESULTS: Sanger-based sequencing of PCR-amplified coding regions was successfully achieved. Sensitivity and specificity of the combined @entity1 /homopolymer protocol was determined to be 100% and 99.5%, respectively. CONCLUSION: In comparison to traditional Sanger-based sequencing, the @entity1 workflow led to a reduction in both cost and analysis time for @entity4 screening. @entity1 analysis achieved high analytical sensitivity and specificity, but required complementary fragment analysis combined with Sanger-based sequencing confirmation in some instances.

title: Diagnostic Screening Workflow for Mutations in the XXXX and @entity2 Genes.

answer: @entity3


abstract: OBJECTIVES: Screening for mutations in large genes is challenging in a molecular diagnostic environment. Sanger-based DNA sequencing methods are largely used; however, @entity1 ( @entity1 ) can accommodate increasing test demands and financial constraints. This study aimed to establish a simple workflow to amplify and screen all coding regions of the @entity3 and @entity2 ( @entity4 ) genes by Sanger-based sequencing as well as to assess a @entity1 approach encompassing multiplex polymerase chain reaction (PCR) and pyrosequencing. METHODS: This study was conducted between July 2011 and April 2013. A total of 20 @entity0 were included in the study who had been referred to Genetic Health Services New Zealand (Northern Hub) for @entity4 mutation screening. @entity0 were randomly divided into a @entity1 evaluation and validation cohort (n = 10 @entity0 each). Primers were designed to amplify all coding exons of @entity4 (28 and 42 primer pairs, respectively). Primers overlying known variants were avoided to circumvent allelic drop-out. The @entity1 approach necessitated utilisation of a complementary fragment analysis assay to eliminate apparent false-positives at homopolymeric regions. Variants were filtered on the basis of their frequency and sequence depth. RESULTS: Sanger-based sequencing of PCR-amplified coding regions was successfully achieved. Sensitivity and specificity of the combined @entity1 /homopolymer protocol was determined to be 100% and 99.5%, respectively. CONCLUSION: In comparison to traditional Sanger-based sequencing, the @entity1 workflow led to a reduction in both cost and analysis time for @entity4 screening. @entity1 analysis achieved high analytical sensitivity and specificity, but required complementary fragment analysis combined with Sanger-based sequencing confirmation in some instances.

title: Diagnostic Screening Workflow for Mutations in the @entity3 and XXXX Genes.

answer: @entity2


abstract: BACKGROUND AND AIM: Previous studies have indicated that neck circumference is a valuable predictor for @entity1 and @entity2 , but little evidence is available for @entity3 . We examined the association of neck circumference with @entity3 and evaluated its predictive value in Chinese adults. METHODS: This cross-sectional study comprised 4053 @entity0 (1617 @entity0 and 2436 @entity0 , aged 20-88) recruited from the Health Examination Center in Guangzhou, China between May 2009 and April 2010. Anthropometric measurements were taken, abdominal ultrasonography was conducted and blood biochemical parameters were measured. Covariance, logistic regression and receiver operating characteristic curve analyses were employed. RESULTS: The mean neck circumference was greater in subjects with @entity3 than those without the disease in both @entity0 and @entity0 after adjusting for age (P<0.001). Logistic regression analysis showed that the age-adjusted ORs (95% CI) of @entity3 for quartile 4 (vs. quartile 1) of neck circumference were 7.70 (4.95-11.99) for @entity0 and 12.42 (9.22-16.74) for @entity0 . After further adjusting for other anthropometric indices, both individually and combined, the corresponding ORs remained significant (all P-trends<0.05) but were attenuated to 1.94-2.53 for @entity0 and 1.45-2.08 for @entity0 . An additive interaction existed between neck circumference and the other anthropometric measures (all P<0.05). A high neck circumference value was associated with a much greater prevalence of @entity3 in @entity0 with both high and normal BMI, waist circumference and waist-to-hip ratio values. CONCLUSIONS: Neck circumference was an independent predictor for @entity3 and provided an additional contribution when applied with other anthropometric measures.

title: Neck Circumference, along with Other Anthropometric Indices, Has an Independent and Additional Contribution in Predicting XXXX .

answer: @entity3


abstract: AIM: To assess the correlation between blood pressure levels and fasting plasma glucose levels among young adults attending Chatrapati Shahuji Maharaj University, Kanpur, India. METHODS: The present study was cross-sectional in nature, conducted among students in the Institute of Paramedical Sciences, Chatrapati Shahuji Maharaj University, Kanpur. Study subjects included 185 young adults. Among them, 94 were males and 91 were females, in the age group 17 to 19 years. RESULTS: Mean age among males was 18.5    1.5 years and among females was 17.9    1.8 years. Of the total 185 study subjects, 61 (32.9%) were classified as pre- @entity0 and 20 (10.8%) as pre- @entity1 . Mean waist circumference, systolic blood pressure and serum high density lipoprotein did not vary significantly between normoglycemic and pre- @entity0 subjects. However, the mean diastolic blood pressure of pre- @entity0 (82    5 mmHg) was significantly higher than normoglycemics (79    6 mmHg). Mean serum cholesterol, serum triglycerides, serum low density lipoprotein (LDL) and serum very low density lipoprotein was also higher among pre- @entity0 subjects in comparison to normoglycemic subjects and the difference was statistically significant. Upon multiple linear regression analysis, it was observed that body mass index (BMI) (b = 0.149), diastolic blood pressure (b = 0.375) and serum LDL (b = 0.483) were significantly associated with fasting plasma glucose. Multiple linear regression with diastolic blood pressure as the outcome variable showed that BMI (b = 0.219), fasting @entity2 (b = 0.247) and systolic blood pressure (b = 0.510) were significantly associated. CONCLUSION: A significant prevalence of @entity0 and pre- @entity1 in young adults is a matter of concern therefore all young adults need to be targeted for screening of @entity0 and @entity1 and lifestyle modification.

title: Correlation between XXXX and hyperglycemia among young adults in India.

answer: @entity1


abstract: UNASSIGNED: Small heat shock proteins 9 and 10 ( @entity2 and HSPB10) are two testis-specific expressed sHsps. The objective of this study was to investigate the mRNA expression profile of @entity2 and HSPB10 in @entity0 testis among the different seasons, ages, and environmental temperatures. Allocation of the two sHsps was also performed by immunohistochemistry. The results showed that the transcript levels of @entity2 and HSPB10 were extremely high in the testis (P < 0.01). The relative expression of HSBP9 and HSPB10 in testis showed a tendency to increase with age and then is maintained at the constant level after sexual maturity. @entity2 and HSPB10 have significantly higher expression in the breeding season      (P < 0.05) and hot season (P < 0.01). Both @entity2 and HSPB10 were found to be upregulated by high-temperature stress in testis (P < 0.05), and the expressions of @entity3 and Hsp90 were also increased simultaneously (P < 0.01). Immunohistochemistry analysis localized @entity2 expressed in spermatogonia, spermatocytes, and round spermatids and HSPB10 expressed in the elongate spermatids. In epididymis, strongly staining signal of HSPB10 was detected in pseudostratified columnar epithelium. In conclusion, the two testis-specific sHsps are closely related to @entity1 . The results could provide valuable data for the further studies on @entity2 and HSPB10.

title: Dual Functions in Response to Heat Stress and Spermatogenesis: Characterization of Expression Profile of Small Heat Shock Proteins 9 and 10 in XXXX Testis.

answer: @entity0


abstract: UNASSIGNED: Brucellosis screening was conducted between 2005 and 2010 at the National Livestock Research Institute headquarters, Mpwapwa, Tanzania, following an abortion storm in @entity1 . The initial screening targeted breeding herds; 483 @entity1 were screened using the Rose Bengal Plate Test (RBPT) followed by the Competitive Enzyme-linked Immunosorbent Assay (c-ELISA) as a confirmatory test. The seropositivity on c-ELISA was 28.95% in 2005; it subsequently declined to 6.72%, 1.17%, 0.16% and 0.00% in 2006, 2007, 2009 and 2010, respectively. Brucella seropositivity was not detected in @entity2 . Seropositivity declined following institution of stringent control measures that included: gradual culling of seropositive animals through slaughter; isolation and confinement of pregnant @entity1 close to calving; proper disposal of placentas and aborted foetuses; the use of the S19 vaccine; and restricted introduction of new animals. It was thought that the source of this outbreak was likely to have been from the introduction of infected animals from another farm. Furthermore, @entity0 were found with @entity3 antibodies. Out of 120 @entity0 screened, 12 (10%) were confirmed seropositive to brucella antigen exposure by c-ELISA analysis. The majority of the seropositive individuals (80%) were milkers and animal handlers from the farm. Nine individuals had clinical signs suggestive of @entity3 . All cases received medical attention from the district hospital. This achievement in livestock and @entity0 health showed that it is possible to control @entity3 in dairy farms, compared to pastoral and agro-pastoral farms, thus providing evidence to adopt these strategies in dairy farms thought to be at risk.

title: Outbreak investigation and control case report of XXXX : Experience from livestock research centre, Mpwapwa, Tanzania.

answer: @entity3


abstract: A second resective procedure has been done on 64 @entity0 with multiple primary @entity2 , and a third operation has been performed in six. Fifty-three initial resections and all repeat procedures were performed at Rush-Presbyterian-St. Luke's Medical Center. Six @entity0 had @entity1 , and in the 58 with metachronous disease the cumulative probability of @entity1 -free interval was 47% at 3 years. The initial resection performed was pneumonectomy in seven, lobectomy in 40, and segmentectomy in 17 @entity0 . At the second operation, segmental resection was done in 41, lobectomy in six, completion lobectomy in four, and completion pneumonectomy in 13 @entity0 . At the third operation, segmentectomy was done in three, completion lobectomy in two, and completion pneumonectomy in one @entity0 . Ten @entity0 had a @entity1 of different histologic type identified at the second procedure, but all @entity0 with three operations had the same @entity1 cell type in each specimen. Six @entity0 died following the second operation (a postoperative mortality of 9.3%), but there were no deaths in the six @entity0 undergoing three procedures. Cumulative survival following the second resection was 36% at 5 years, 22% at 10 years and 13% at 15 years. In summary, second or third surgical efforts for reappearing @entity1 are justified and have significantly prolonged survival. The use of segmental or subsegmental resective techniques have provided superior survival results.

title: Survival following resection for second primary XXXX .

answer: @entity2


abstract: OBJECTIVE: @entity1 is a major problem among European ethnic minority groups. We assessed the current situation of @entity1 prevalence and its management among a multi-ethnic population in Amsterdam, The Netherlands. METHODS: Data from the HELIUS study were used including 12,974 @entity0 (1871 Ghanaian, 2184 African Surinamese, 2278 South-Asian Surinamese, 2277 Turkish, 2222 Moroccan and 2142 Dutch origin @entity0 ), aged 18-70years. Comparisons among groups were made using proportions and age-adjusted prevalence ratios (PRs). RESULTS: @entity1 prevalence ranged from 24% and 16% in Moroccan @entity0 and @entity0 to 52% and 62% in Ghanaian @entity0 and @entity0 . Except for Moroccan @entity0 , age-adjusted PR of @entity1 was higher in all the ethnic minority groups than in Dutch. Among @entity1 , ethnic minority groups generally had higher levels of @entity1 awareness and BP lowering treatment than Dutch. Moreover, prevalence rates for the prescription of more than one BP lowering drug were generally higher in African and South-Asian origin groups compared with Dutch origin @entity0 . By contrast, BP control levels were lower in all the ethnic groups than in Dutch, with control rates being significantly lower in Ghanaian @entity0 (26%, PR=0.49; 95% CI, 0.37-0.66) and @entity0 (45%, PR=0.64; 0.52-0.77), African-Surinamese @entity0 (30%, PR=0.61; 0.46-0.81) and @entity0 (45%, PR=0.72; 0.51-0.77), and South-Asian Surinamese @entity0 (43%, PR=0.77; 0.61-0.97) and @entity0 (47%, PR=0.76; 0.63-0.92) compared with Dutch @entity0 (53%) and @entity0 (61%). CONCLUSION: Our findings indicate poor BP control in ethnic minority groups despite the high treatment levels. More work is needed to unravel the potential factors contributing to the poor control in order to improve BP control in ethnic minority groups, particularly among African and South-Asian origin groups.

title: XXXX control in a large multi-ethnic cohort in Amsterdam, The Netherlands: The HELIUS study.

answer: @entity1


abstract: UNASSIGNED: A superior @entity1 (SSPOA) is a collection of purulent material between the periorbit and the superior bony orbital wall, and is typically a @entity3 . SSPOA is characteristically managed by classic external surgical drainage. The aim of our study was to assess the role of surgical intervention in SSPOA. A retrospective medical chart review of @entity0 diagnosed with SSPOA secondary to rhinosinusitis between the year 2005 and 2013 was conducted. Collected data included age, gender, co-morbidity, clinical presentation, prior antibiotic management, CT scans, surgical approach, outcome and complications. Six @entity0 were included in our study, three males and three females with a mean age of 22.8 (range 9-58). Two @entity0 were treated with @entity2 for 3  days prior to admission. Only the youngest @entity0 with the smallest abscess responded successfully to conservative treatment, while the rest were managed surgically: three @entity0 were treated successfully by the endonasal endoscopic approach and two @entity0 were treated by utilizing the combined endonasal endoscopic and external approach. In @entity0 who underwent the combined approach, the abscess was located in a more antero-lateral position than those treated endonasal endoscopically only. The location of a SSPOA dictates the surgical approach. The most antero-lateral SSPOAs should be drained by the combined approach, while more posterior abscesses should be approached endoscopically. Furthermore, a small SSPOA is first to be reported to resolve with conservative treatment. Level 4 (case series).

title: Management of superior XXXX .

answer: @entity1


abstract: INTRODUCTION: @entity3 occur rarely but are among the most dreadful complications following cholecystectomies. METHODS: Prospective registration of bile duct @entity1 occurring in the period 1992-2013 at a tertiary referral hospital. RESULTS: In total, 67 @entity0 (47 @entity0 and 20 @entity0 ) with a median age of 55 (range 14-86) years had a leak or a lesion of the bile ducts during the study period. Total incidence of postoperative @entity3 or bile duct @entity1 was 0.9% and for bile duct @entity1 separately, 0.4%. Median delay from @entity1 was 5   days (range 0-68   days). In 12 @entity0 (18%), the injury was discovered intraoperatively. @entity3 was the major symptom in 59%, and 52% had a leak from the cystic duct or from assumed aberrant ducts in the liver bed of the @entity2 . Following the Clavien-Dindo classification, 39% and 45% were classified as IIIa and IIIb, respectively, 10% as IV, and 6% as V. In all, 31 @entity0 had @entity1 to the common bile duct or hepatic ducts, and in these @entity0 , 71% were treated with a hepaticojejunostomy. Of @entity0 treated with a hepaticojejunostomy, 56% had an uncomplicated event, whereas 14% later on developed a stricture. Out of 36 @entity0 with @entity1 to the cystic duct/aberrant ducts, 30 could be treated with stents or sphincterotomies and percutaneous drainage. CONCLUSION: Half of @entity1 following cholecystectomies are related to the cystic duct, and most of these can be treated with endoscopic or percutaneous procedures. A considerable number of @entity0 following hepaticojejunostomy will later on develop a stricture.

title: XXXX following laparoscopic cholecystectomy.

answer: @entity3


abstract: Objective: Poor sleep is a frequent symptom in @entity0 with @entity1 ( @entity1 ). The objective of the study was to assess the relationship between nocturnal polysomnographic (PSG) findings and quality of sleep, fatigue, and increased @entity2 among @entity0 with @entity1 . Methods: Clinical characteristics were collected. Pittsburgh Sleep Quality Index (PSQI), @entity6 ( @entity6 ), @entity2 ( @entity2 ), and International @entity7 Rating Scale were used to assess quality of sleep, fatigue, excessive @entity2 , and the presence of @entity7 ( @entity7 ). All @entity0 underwent nocturnal diagnostic PSG examination. Results: Fifty @entity0 with @entity1 were enrolled into the study. Age was the only independent variable significantly determining @entity3 index and @entity4 ( @entity4 ) (beta = 0.369, p = 0.010, beta 0.301, p = 0.040). PSQI and @entity2 score were significantly higher in a population with @entity7 (p = 0.004, p = 0.011). @entity6 significantly correlated with @entity4 (r = 0.400, p = 0.048). Presence of @entity7 was the only independent variable significantly determining PSQI and @entity2 (p = 0.005, p = 0.025). @entity4 and presence of @entity7 were independent variables determining @entity6 (p = 0.015, p = 0.024). Conclusion: Presence of @entity7 seems to be the main factor determining poor sleep, fatigue, and daytime somnolence. @entity2 @entity5 and its severity influences only fatigue in @entity0 with @entity1 .

title: @entity2 in @entity0 With XXXX .

answer: @entity1


abstract: Objective: Poor sleep is a frequent symptom in @entity0 with @entity1 ( @entity1 ). The objective of the study was to assess the relationship between nocturnal polysomnographic (PSG) findings and quality of sleep, fatigue, and increased @entity2 among @entity0 with @entity1 . Methods: Clinical characteristics were collected. Pittsburgh Sleep Quality Index (PSQI), @entity6 ( @entity6 ), @entity2 ( @entity2 ), and International @entity7 Rating Scale were used to assess quality of sleep, fatigue, excessive @entity2 , and the presence of @entity7 ( @entity7 ). All @entity0 underwent nocturnal diagnostic PSG examination. Results: Fifty @entity0 with @entity1 were enrolled into the study. Age was the only independent variable significantly determining @entity3 index and @entity4 ( @entity4 ) (beta = 0.369, p = 0.010, beta 0.301, p = 0.040). PSQI and @entity2 score were significantly higher in a population with @entity7 (p = 0.004, p = 0.011). @entity6 significantly correlated with @entity4 (r = 0.400, p = 0.048). Presence of @entity7 was the only independent variable significantly determining PSQI and @entity2 (p = 0.005, p = 0.025). @entity4 and presence of @entity7 were independent variables determining @entity6 (p = 0.015, p = 0.024). Conclusion: Presence of @entity7 seems to be the main factor determining poor sleep, fatigue, and daytime somnolence. @entity2 @entity5 and its severity influences only fatigue in @entity0 with @entity1 .

title: XXXX in @entity0 With @entity1 .

answer: @entity2


abstract: Objective: Poor sleep is a frequent symptom in @entity0 with @entity1 ( @entity1 ). The objective of the study was to assess the relationship between nocturnal polysomnographic (PSG) findings and quality of sleep, fatigue, and increased @entity2 among @entity0 with @entity1 . Methods: Clinical characteristics were collected. Pittsburgh Sleep Quality Index (PSQI), @entity6 ( @entity6 ), @entity2 ( @entity2 ), and International @entity7 Rating Scale were used to assess quality of sleep, fatigue, excessive @entity2 , and the presence of @entity7 ( @entity7 ). All @entity0 underwent nocturnal diagnostic PSG examination. Results: Fifty @entity0 with @entity1 were enrolled into the study. Age was the only independent variable significantly determining @entity3 index and @entity4 ( @entity4 ) (beta = 0.369, p = 0.010, beta 0.301, p = 0.040). PSQI and @entity2 score were significantly higher in a population with @entity7 (p = 0.004, p = 0.011). @entity6 significantly correlated with @entity4 (r = 0.400, p = 0.048). Presence of @entity7 was the only independent variable significantly determining PSQI and @entity2 (p = 0.005, p = 0.025). @entity4 and presence of @entity7 were independent variables determining @entity6 (p = 0.015, p = 0.024). Conclusion: Presence of @entity7 seems to be the main factor determining poor sleep, fatigue, and daytime somnolence. @entity2 @entity5 and its severity influences only fatigue in @entity0 with @entity1 .

title: @entity2 in XXXX With @entity1 .

answer: @entity0


abstract: Objective: @entity1 ( @entity1 ) is a @entity2 associated with a multitude of adverse outcomes when left untreated. There is significant heterogeneity in the evaluation and management of @entity1 resulting in variation in cost and outcomes. Thus, the goal for developing these measures was to have a way to evaluate the outcomes and reliability of the processes involved with the standard care approaches used in the diagnosis and management of @entity1 . The @entity1 quality care metrics presented here focus on both outcomes and processes. The AASM commissioned the Adult @entity1 Quality Measures Workgroup to develop quality care metrics aimed at optimizing care for @entity0 with @entity1 . These quality care metrics developed by the Adult @entity1 Quality Measures Workgroup are an extension of the original Centers for Medicare _ Medicaid Services (CMS) approved Physician Quality Reporting System (PQRS) measures group for @entity1 . The measures are based on the available scientific evidence, focus on public safety, and strive to improve quality of life and cardiovascular outcomes for individual @entity1 @entity0 . The three outcome measures that were selected were as follows: (1) improve disease detection and categorization; (2) improve quality of life; and (3) reduce cardiovascular risk. After determining these relevant outcome measures, a total of ten process measures were chosen that could be applied and assessed for the purpose of accomplishing the outcomes measures. The measures described in this document may be reported through the @entity0 Quality Reporting System (PQRS) in addition to, or as a replacement for, the current @entity1 measures group. The overall objective for the development of these measures is that implementation of these quality metrics will result in improved @entity0 outcomes, reduce the public health burden of @entity1 , and provide a measurable standard for evaluating and managing @entity1 .

title: Quality Measures for the Care of Adult XXXX with Obstructive Sleep Apnea.

answer: @entity0


abstract: Mathematical models of the proximal tubule (PT), loop of Henle (LOH), and distal nephron have been combined to simulate transport by @entity0 renal tubules. The ensemble is composed of 24,000 superficial (SF) nephrons and 12,000 juxtamedullary (JM) nephrons in 5 classes (according to LOH length); all coalesce into 7,200 connecting tubules (CNT). Medullary interstitial solute concentrations are specified. The model equations require that each nephron glomerular filtration rate (GFR) satisfies a tubuloglomerular feedback (TGF) relationship, and each initial hydrostatic pressure yields a common CNT pressure; that common CNT pressure is determined from an overall distal hydraulic resistance to flow. By virtue of the greater GFR for JM nephrons, fluid delivery to SF and JM tubules is comparable. Glucose reabsorption is restricted to the PT, cotransported with one Na in the convoluted tubule ( @entity4 ), and two Na in the straight tubule ( @entity3 ). Increasing ambient glucose from 5 to 10 mM increases proximal Na reabsorption and decreases distal delivery. This is mitigated by a TGF-mediated increase in GFR, and may thus be an etiology for TGF-mediated glomerular hyperfiltration. With @entity4 inhibition by 95%, the model predicts that under normoglycemic conditions about 60% of filtered glucose will still be reabsorbed, so that profound @entity2 is not to be expected. Compared with glucose-driven osmotic diuresis, @entity4 inhibition provokes greater natriuresis. When @entity1 is superimposed on @entity4 inhibition, the model suggests that natriuresis may be severe, reflecting synergy of a proximal diuretic and osmotic diuresis. In sum, the model captures TGF-mediated diabetic hyperfiltration and predicts glomerular protection with @entity4 inhibition.

title: A mathematical model of the XXXX nephron: glucose transport.

answer: @entity0


abstract: Haemodynamic forces appear to play an influential role in the evolution of @entity1 . This has led to numerous studies, usually based on computational fluid dynamics. Their focus is predominantly on the @entity3 ( @entity3 ) and associated derived parameters, attempting to find correlations between particular patterns of haemodynamic indices and regions subjected to disease formation and progression. The indices are generally determined by integration of flow properties over a single cardiac cycle. In this study, we illustrate that in some cases the transitional flow in @entity1 can lead to significantly different @entity3 distributions in consecutive cardiac cycles. Accurate determination of time-averaged haemodynamic indices may thus require simulation of a large number of cycles, which contrasts with the common approach to determine parameters using data from a single cycle. To demonstrate the role of transitional flow, two exemplary cases are considered: flow in an @entity2 and in an @entity0 . The key differences that are observed between these cases are explained in terms of the integral timescale of the transitional flows in comparison with the cardiac cycle duration: for relatively small geometries, transients will decay before the next cardiac cycle. In larger geometries, transients are still present when the systolic phase produces new instabilities. These residual fluctuations serve as random initial conditions and thus seed different flow patterns in each cycle. To judge whether statistics are converged, the derived indices from at least two successive cardiac cycles should be compared.

title: Transitional flow in XXXX and the computation of haemodynamic parameters.

answer: @entity1


abstract: OBJECTIVE: The purpose of this study was to assess the consequences of a national immunization program with HPV vaccine for both @entity0 and @entity0 in Denmark, including the prophylactic effects on all potentially vaccine preventable @entity2 in male and female. METHODS: The study focussed on the quadrivalent vaccine which protects against @entity4 , 11, 16 and 18, and the vaccine's protection against genital warts, @entity5 , cervical @entity1 (anal, @entity1 ) and @entity3 (oral cavity, oropharyngeal, hypopharyngeal and @entity1 ) were included in the analyses. In general, the analysis was performed in two phases. First, an agent-based transmission model that described the HPV transmission without and with HPV vaccination was applied. Second, an analysis of the incremental costs and effects was performed. The model did not include naturally-acquired immunity to HPV in the simulations. RESULTS: In the base case result (i.e. vaccination of @entity0 only, 85% vaccination rate, private market price at     123 per dose ex. VAT) an ICER of 3583    /QALY (3-dose regime) is estimated when all @entity2 are taken into account. Vaccination of @entity0 _ @entity0 vs. vaccination of @entity0 only an ICER of 28,031    /QALY (2-dose regime) and 41,636    /QALY (3-dose regime) is estimated. CONCLUSIONS: Extension of the current HPV programme in Denmark to include @entity0 and @entity0 is a cost effective preventive intervention that would lead to a faster prevention of @entity1 , @entity1 precursors and genital warts in @entity0 and @entity0 .

title: Revisiting the cost-effectiveness of universal HPV-vaccination in Denmark accounting for all potentially vaccine preventable XXXX in males and females.

answer: @entity2


abstract: OBJECTIVES: To evaluate the potential benefit of systematic preoperative @entity2 angiography followed by selective @entity2 revascularization on the incidence of @entity3 ( @entity3 ) in @entity0 undergoing carotid endarterectomy (CEA) without a previous history of @entity2 ( @entity2 ). METHODS: We randomised 426 @entity0 who were candidates for CEA, with no history of @entity2 , a normal electrocardiogram (ECG), and a normal cardiac ultrasound. In group A (n  =  216) all @entity0 underwent coronary angiography before CEA. In group B (n  =  210) CEA was performed without coronary angiography. @entity0 were not blinded for relevant assessments during follow-up. Primary end-point was the occurrence of @entity3 at 3.5 years. The secondary end-point was the overall survival rate. Median length of follow-up was 6.2 years. RESULTS: In group A, coronary angiography revealed significant @entity4 in 68 @entity0 (31.5%). Among them, 66 underwent percutaneous Intervention (PCI) prior to CEA and 2 received combined CEA and @entity2 bypass grafting (CABG). Postoperatively, no @entity3 was observed in group A, whereas 6 @entity3 occurred in group B, one of which was fatal (p  =  .01). During the study period, 3 @entity3 occurred in group A (1.4%) and 33 were observed in group B (15.7%), 6 of which were fatal. The Cox model demonstrated a reduced risk of @entity3 for @entity0 in group A receiving coronary angiography (HR,.078; 95% CI, 0.024-0.256; p  <  .001). In addition, @entity0 with @entity1 and @entity0 <70 years presented with an increased risk of @entity3 . Survival analysis at 6 years by Kaplan-Meier estimates was 95.6      3.2% in Group A and 89.7      3.7% in group B (Log Rank  =  6.54, p  =  .01). CONCLUSIONS: In asymptomatic @entity2 @entity0 , systematic coronary angiography prior to CEA followed by selective PCI or CABG significantly reduces the incidence of late @entity3 and increases long-term survival. (ClinicalTrials.gov number, NCT02260453).

title: Long-term results of a randomized controlled trial analyzing the role of systematic pre-operative coronary angiography before elective carotid endarterectomy in @entity0 with asymptomatic XXXX .

answer: @entity2


abstract: OBJECTIVES: To evaluate the potential benefit of systematic preoperative @entity2 angiography followed by selective @entity2 revascularization on the incidence of @entity3 ( @entity3 ) in @entity0 undergoing carotid endarterectomy (CEA) without a previous history of @entity2 ( @entity2 ). METHODS: We randomised 426 @entity0 who were candidates for CEA, with no history of @entity2 , a normal electrocardiogram (ECG), and a normal cardiac ultrasound. In group A (n  =  216) all @entity0 underwent coronary angiography before CEA. In group B (n  =  210) CEA was performed without coronary angiography. @entity0 were not blinded for relevant assessments during follow-up. Primary end-point was the occurrence of @entity3 at 3.5 years. The secondary end-point was the overall survival rate. Median length of follow-up was 6.2 years. RESULTS: In group A, coronary angiography revealed significant @entity4 in 68 @entity0 (31.5%). Among them, 66 underwent percutaneous Intervention (PCI) prior to CEA and 2 received combined CEA and @entity2 bypass grafting (CABG). Postoperatively, no @entity3 was observed in group A, whereas 6 @entity3 occurred in group B, one of which was fatal (p  =  .01). During the study period, 3 @entity3 occurred in group A (1.4%) and 33 were observed in group B (15.7%), 6 of which were fatal. The Cox model demonstrated a reduced risk of @entity3 for @entity0 in group A receiving coronary angiography (HR,.078; 95% CI, 0.024-0.256; p  <  .001). In addition, @entity0 with @entity1 and @entity0 <70 years presented with an increased risk of @entity3 . Survival analysis at 6 years by Kaplan-Meier estimates was 95.6      3.2% in Group A and 89.7      3.7% in group B (Log Rank  =  6.54, p  =  .01). CONCLUSIONS: In asymptomatic @entity2 @entity0 , systematic coronary angiography prior to CEA followed by selective PCI or CABG significantly reduces the incidence of late @entity3 and increases long-term survival. (ClinicalTrials.gov number, NCT02260453).

title: Long-term results of a randomized controlled trial analyzing the role of systematic pre-operative coronary angiography before elective carotid endarterectomy in XXXX with asymptomatic @entity2 .

answer: @entity0


abstract: PURPOSE: Limited data are available regarding the oncologic efficacy of pelvic lymph node dissection (PLND) performed during robotic-assisted laparoscopic prostatectomy (RALP) for @entity2 . We aimed to determine the frequency of pelvic lymph node @entity1 and oncological outcomes following RALP with PLND in @entity0 who did not receive adjuvant @entity3 deprivation therapy (ADT). METHODS: We retrospectively reviewed the records of 1740 consecutive @entity0 who underwent RALP and extended PLND. The primary endpoint was biochemical recurrence (BCR). The estimated BCR probability was obtained using the Kaplan-Meier method. Cox proportional hazard regression models were used to assess for predictors of BCR. RESULTS: One hundred and eight @entity0 (6  %) with positive LNs were identified. The median number of LNs removed was 17 (IQR 11-24), and median follow-up was 26  months (IQR 14-43). Ninety-one (84  %) @entity0 did not receive adjuvant ADT of whom 60  % had BCR with a median time to recurrence of 8  months. The 1- and 3-year BCR-free probability was 42 and 28  %, respectively. @entity0 with  <=2 LN+ had significantly better biochemical-free estimated probability compared to those with >2 LN+ (p  =  0.002). The total number of LN+ (HR  =  1.1; 95  % CI 1.01-1.2, p  =  0.04) and Gleason 8-10 (HR  =  1.96; 95  % CI 1.1-3.4, p  =  0.02) were predictors of BCR on multivariate analysis. CONCLUSION: Among @entity0 with positive lymph nodes at time of robotic prostatectomy, those with two or fewer positive nodes and Gleason <8 exhibited favorable biochemical-free survival without adjuvant therapy.

title: Robotic-assisted pelvic lymph node dissection for XXXX : frequency of nodal metastases and oncological outcomes.

answer: @entity2


abstract: During the summer of 1977, an @entity2 of @entity1 occurred among adults in Hawaii. The highest attack rate was in @entity0 20-24 years old (226/100,000), with almost total sparing of young schoolchildren. A case-control investigation implicated a specific discotheque as a common place of exposure for @entity0 with onset of disease during the @entity2 peak (chi 2 = 12.9,p less than 0.001). A piano player/singer at the discotheque was the apparent source of the virus transmission. The large number of cases linked to this musician suggests that airborne transmission occurred while he was singing rather than by direct @entity0 -to- @entity0 contact. @entity1 vaccine was given to 6523 @entity0 in public clinics held during the @entity2 . Despite screening for pregnancy and birth control usage, 23 @entity0 (3.5/1000) became pregnant within three months after receiving the vaccine. Eleven of 12 @entity0 who reportedly contracted natural @entity1 while pregnant elected to terminate their pregnancies; the 12th had a normal appearing @entity0 . The susceptibility rate for all adults tested for @entity1 hemagglutination inhibition antibody was 36.9%, a rate similar to the found in earlier surveys in Hawaii. The occurrence of this @entity2 confirms the changing epidemiology of @entity1 with respect to age distribution and supports the view that vaccination of young @entity0 may not be sufficient to protect adult @entity0 from exposure to @entity1 , especially in areas where a high proportion of adults remain susceptible.

title: Saturday night fever: a common-source outbreak of XXXX among adults in Hawaii.

answer: @entity1


abstract: BACKGROUND: Currently, non-invasive methods for screening @entity3 and @entity1 are lacking. The purpose of this study was to evaluate the value of serological parameters including serum @entity4 ( @entity4 ), @entity5 ( @entity5 ) and @entity4 : II ratio for the screening @entity3 and @entity1 . METHODS: The study population consisted of 132 dyspeptic @entity0 who had undergone upper endoscopy with biopsy. Blood samples for ELISA assays of serum @entity4 , @entity5 and IgG antibodies against @entity2 were drawn. Comparison between the two groups was done by Student's t- test, and Mann Whitney test. Cut-off points were calculated using receiver operating curves (ROC). RESULTS: Mean (  SD) age of the study population was 51.4 (  15.5) years. Values of @entity4 and PG ratio decreased significantly in the @entity3 as compared with the control group (p<0.05). Values of PG and PG ratio didn't show any significant difference between the @entity1 and control group (p>0.05). For @entity0 with @entity3 , the area under the ROC for @entity4 was 0.639 (95% CI:0.538-0.741, p=0.008) in which the best cut-off value was 40 g/L (sensitivity 90%, specificity 67%, accuracy 69%, negative predictive value 92%, YI : 0.429). The area under the ROC for PG ratio was 0.711 (95% CI: 0.617-0.806, p=0.0001) and the best cut-off value was 8 (sensitivity 71%, specificity 71%, accuracy 71%, negative predictive value 86%,YI : 0.431). CONCLUSION: It seems that @entity4 , @entity4 : @entity5 ratio is potential biomarkers for screening @entity3 with high sensitivity, specificity, accuracy and negative predictive value. Serology could be used as a screening method for the detection of precancerous states due to its convenience, relative low cost and safety.

title: Accuracy of pepsinogens for early diagnosis of @entity3 and XXXX in Iranian population.

answer: @entity1


abstract: BACKGROUND: Currently, non-invasive methods for screening @entity3 and @entity1 are lacking. The purpose of this study was to evaluate the value of serological parameters including serum @entity4 ( @entity4 ), @entity5 ( @entity5 ) and @entity4 : II ratio for the screening @entity3 and @entity1 . METHODS: The study population consisted of 132 dyspeptic @entity0 who had undergone upper endoscopy with biopsy. Blood samples for ELISA assays of serum @entity4 , @entity5 and IgG antibodies against @entity2 were drawn. Comparison between the two groups was done by Student's t- test, and Mann Whitney test. Cut-off points were calculated using receiver operating curves (ROC). RESULTS: Mean (  SD) age of the study population was 51.4 (  15.5) years. Values of @entity4 and PG ratio decreased significantly in the @entity3 as compared with the control group (p<0.05). Values of PG and PG ratio didn't show any significant difference between the @entity1 and control group (p>0.05). For @entity0 with @entity3 , the area under the ROC for @entity4 was 0.639 (95% CI:0.538-0.741, p=0.008) in which the best cut-off value was 40 g/L (sensitivity 90%, specificity 67%, accuracy 69%, negative predictive value 92%, YI : 0.429). The area under the ROC for PG ratio was 0.711 (95% CI: 0.617-0.806, p=0.0001) and the best cut-off value was 8 (sensitivity 71%, specificity 71%, accuracy 71%, negative predictive value 86%,YI : 0.431). CONCLUSION: It seems that @entity4 , @entity4 : @entity5 ratio is potential biomarkers for screening @entity3 with high sensitivity, specificity, accuracy and negative predictive value. Serology could be used as a screening method for the detection of precancerous states due to its convenience, relative low cost and safety.

title: Accuracy of pepsinogens for early diagnosis of XXXX and @entity1 in Iranian population.

answer: @entity3


abstract: INTRODUCTION: To delineate an optimal clinical target volume (CTV) for @entity1 by comparing locoregional versus extended locoregional @entity5 ( @entity5 ) volumes. MATERIALS: This retrospective analysis examined 222 @entity0 (111 matched pairs treated with locoregional versus extended locoregional @entity5 ) with nonmetastatic @entity2 treated with concurrent chemoradiation    surgery. The CTV for locoregional volumes was defined as gross @entity1 volume + elective coverage of first-echelon nodes and sometimes the celiac axis. The CTV for extended locoregional volumes was defined as gross @entity1 volume + elective coverage of celiac and @entity6 (  porta) nodes. Variables used for matching included sex, stage, performance status, histology, receipt of induction chemotherapy, type of concurrent chemotherapy, @entity5 modality, receipt of surgery, type of surgery, and Siewert classification. Regression models stratified by matched pairs were fit to estimate effect of @entity5 volume on clinical endpoints. RESULTS: Adjusting p values for multiple testing, @entity0 treated with extended locoregional versus locoregional @entity5 had increased odds of grade 2+ acute chemoradiation-associated @entity4 (odds ratio: 2.92, adj. p = 0.0447). However, differing @entity5 volumes were not significantly associated with @entity3 rates, pathologic T-stage, frequency of positive perigastric/regional nodes on surgical specimen, distant-metastases progression-free survival, locoregional progression-free survival, or overall survival (adj. p > 0.05). Of the @entity0 who did (n = 124) and did not (n = 72) receive elective celiac @entity5 , two (1.6%) and two @entity0 (2.8%), respectively, relapsed in the celiac nodes. No @entity0 failed in the @entity6 or porta nodes. CONCLUSIONS: Most @entity1 can be safely treated without elective inclusion of @entity6 /porta nodes.

title: Comparison of Locoregional versus Extended Locoregional Radiation Volumes for @entity0 with Nonmetastatic Gastro-esophageal Junction XXXX .

answer: @entity2


abstract: INTRODUCTION: To delineate an optimal clinical target volume (CTV) for @entity1 by comparing locoregional versus extended locoregional @entity5 ( @entity5 ) volumes. MATERIALS: This retrospective analysis examined 222 @entity0 (111 matched pairs treated with locoregional versus extended locoregional @entity5 ) with nonmetastatic @entity2 treated with concurrent chemoradiation    surgery. The CTV for locoregional volumes was defined as gross @entity1 volume + elective coverage of first-echelon nodes and sometimes the celiac axis. The CTV for extended locoregional volumes was defined as gross @entity1 volume + elective coverage of celiac and @entity6 (  porta) nodes. Variables used for matching included sex, stage, performance status, histology, receipt of induction chemotherapy, type of concurrent chemotherapy, @entity5 modality, receipt of surgery, type of surgery, and Siewert classification. Regression models stratified by matched pairs were fit to estimate effect of @entity5 volume on clinical endpoints. RESULTS: Adjusting p values for multiple testing, @entity0 treated with extended locoregional versus locoregional @entity5 had increased odds of grade 2+ acute chemoradiation-associated @entity4 (odds ratio: 2.92, adj. p = 0.0447). However, differing @entity5 volumes were not significantly associated with @entity3 rates, pathologic T-stage, frequency of positive perigastric/regional nodes on surgical specimen, distant-metastases progression-free survival, locoregional progression-free survival, or overall survival (adj. p > 0.05). Of the @entity0 who did (n = 124) and did not (n = 72) receive elective celiac @entity5 , two (1.6%) and two @entity0 (2.8%), respectively, relapsed in the celiac nodes. No @entity0 failed in the @entity6 or porta nodes. CONCLUSIONS: Most @entity1 can be safely treated without elective inclusion of @entity6 /porta nodes.

title: Comparison of Locoregional versus Extended Locoregional Radiation Volumes for XXXX with Nonmetastatic Gastro-esophageal Junction @entity2 .

answer: @entity0


abstract: UNASSIGNED: Objectives: To compare the hearing results and graft take rates of the recently developed gold wire prosthesis with those of the @entity2 partial ossicular replacement prosthesis in @entity0 with @entity1 media. Method: This retrospective study examined @entity0 who underwent type 2 tympanoplasty with a minimum follow up of one year. The study population consisted of 32 @entity0 in the partial ossicular replacement prosthesis group and 26 @entity0 in the gold wire group. The main outcome measures were the graft success rate and level of hearing improvement. Complications and extrusion rates were also noted. Results: The graft take rate was 90.6 per cent for the partial ossicular replacement prosthesis group and 92.3 per cent for the gold wire group (p  =  0.848). Pre-operatively, there were no significant differences in the air or bone-conduction thresholds between groups. Post-operatively, the mean hearing gain was 18.5      14.0  dB in the partial ossicular replacement prosthesis group and 16.5      10.6  dB in the gold wire group (p  =  0.555). The mean air-conduction thresholds were 26.6      12.4 and 32.6      10.5  dB, respectively (p  =  0.027), and the mean bone-conduction thresholds were 9.7      7.0 and 10.4      6.4  dB, respectively (p  =  0.687). Conclusion: The success and complication rates provided by the gold wire prosthesis seem comparable to those of the @entity2 partial ossicular replacement prosthesis.

title: Outcomes with gold wire and XXXX partial ossicular replacement prostheses in type 2 tympanoplasty: a preliminary study.

answer: @entity2


abstract: BACKGROUND: Idiopathic @entity6 (IGM) is a @entity5 that has been described as a rare @entity3 ( @entity3 ). It can mimic @entity0 . MASTERIAL AND METHODS: We included @entity1 with a diagnosis of IGM referred to an oncologic hospital between January 01, 2007 and to March 31, 2011, with diagnosis of @entity0 , in whom biopsy reported @entity3 , without other cause related. The aim of this study was to review the clinical, radiologic and pathologic characteristics of a cohort of @entity1 with IGM. RESULTS: We analyzed 58 @entity1 ; mean age was 38    12 years. Mammography showed diffuse asymmetry (n = 19) and focal asymmetry (n = 13); breast ultrasound showed heterogeneous and hypoechoic areas (n = 28) and lumps (n = 21) as the most frequent lesions. All biopsies showed lobulocentric @entity3 . Treatment included antibiotics (n = 20), @entity4 (n = 8), both treatments (n = 20), surgical excision (n = 3) and observation (n = 7). Forty-three @entity1 (74%) had complete remission; mean time to remission was 9.5    5.8 months. Fifteen (26%) had partial remission. Any @entity1 had progression or relapse. CONCLUSIONS: IGM is a benign breast condition that may mimic @entity0 . Ultrasonography and mammography findings reveal characteristic data that can be useful for establishing the diagnosis; however, biopsy is the gold standard for its diagnosis and should be taken in any @entity1 even with a mild suspicion of @entity2 .

title: Idiopathic @entity6 . Experience at a XXXX center.

answer: @entity2


abstract: BACKGROUND: Idiopathic @entity6 (IGM) is a @entity5 that has been described as a rare @entity3 ( @entity3 ). It can mimic @entity0 . MASTERIAL AND METHODS: We included @entity1 with a diagnosis of IGM referred to an oncologic hospital between January 01, 2007 and to March 31, 2011, with diagnosis of @entity0 , in whom biopsy reported @entity3 , without other cause related. The aim of this study was to review the clinical, radiologic and pathologic characteristics of a cohort of @entity1 with IGM. RESULTS: We analyzed 58 @entity1 ; mean age was 38    12 years. Mammography showed diffuse asymmetry (n = 19) and focal asymmetry (n = 13); breast ultrasound showed heterogeneous and hypoechoic areas (n = 28) and lumps (n = 21) as the most frequent lesions. All biopsies showed lobulocentric @entity3 . Treatment included antibiotics (n = 20), @entity4 (n = 8), both treatments (n = 20), surgical excision (n = 3) and observation (n = 7). Forty-three @entity1 (74%) had complete remission; mean time to remission was 9.5    5.8 months. Fifteen (26%) had partial remission. Any @entity1 had progression or relapse. CONCLUSIONS: IGM is a benign breast condition that may mimic @entity0 . Ultrasonography and mammography findings reveal characteristic data that can be useful for establishing the diagnosis; however, biopsy is the gold standard for its diagnosis and should be taken in any @entity1 even with a mild suspicion of @entity2 .

title: Idiopathic XXXX . Experience at a @entity2 center.

answer: @entity6


abstract: OBJECTIVES: To analyze the link between @entity2 ( @entity2 ) reported in the past year and @entity1 in pregnant Mexican @entity0 . MATERIAL AND METHODS: The data were obtained from the National Addictions Survey (ENA) 2008. For the purposes of this paper, we analyzed a sample of @entity0 over 18 who reported being pregnant at the time of the interview (n = 250). When this number is weighted at the population level, it represents 881,575 @entity0 across the country. The   2 test was used to analyze demographic characteristics, prevalence of @entity1 and @entity2 . A multiple logistic regression was performed to estimate predictors of @entity1 during pregnancy. RESULTS: The prevalence of any type of @entity2 ( @entity2 ) was 5.4% and of @entity1 was 16.2% (CES-D >=  16). A total of 53.4% of pregnant @entity0 who reported @entity2 during the past year had @entity1 whereas this occurred in 14.1% of those who had not been victimized. The variables that predicted @entity1 during pregnancy were having been a victim of @entity2 (OR = 6.23) and having nine years or less of schooling (OR = 5.26). Working outside the home and family income level did not increase the risk of @entity1 in this population. CONCLUSIONS: This population study, representative at the national level, provides an initial overview of the link between @entity2 and @entity1 in pregnant @entity0 in M  xico. The results highlight the need to expand research on the topics covered, as well as to detect both phenomena in a timely manner during pregnancy in order to propose the necessary care.

title: Intimate partner violence and XXXX in pregnant Mexican @entity0 : national survey results.

answer: @entity1


abstract: OBJECTIVES: To analyze the link between @entity2 ( @entity2 ) reported in the past year and @entity1 in pregnant Mexican @entity0 . MATERIAL AND METHODS: The data were obtained from the National Addictions Survey (ENA) 2008. For the purposes of this paper, we analyzed a sample of @entity0 over 18 who reported being pregnant at the time of the interview (n = 250). When this number is weighted at the population level, it represents 881,575 @entity0 across the country. The   2 test was used to analyze demographic characteristics, prevalence of @entity1 and @entity2 . A multiple logistic regression was performed to estimate predictors of @entity1 during pregnancy. RESULTS: The prevalence of any type of @entity2 ( @entity2 ) was 5.4% and of @entity1 was 16.2% (CES-D >=  16). A total of 53.4% of pregnant @entity0 who reported @entity2 during the past year had @entity1 whereas this occurred in 14.1% of those who had not been victimized. The variables that predicted @entity1 during pregnancy were having been a victim of @entity2 (OR = 6.23) and having nine years or less of schooling (OR = 5.26). Working outside the home and family income level did not increase the risk of @entity1 in this population. CONCLUSIONS: This population study, representative at the national level, provides an initial overview of the link between @entity2 and @entity1 in pregnant @entity0 in M  xico. The results highlight the need to expand research on the topics covered, as well as to detect both phenomena in a timely manner during pregnancy in order to propose the necessary care.

title: Intimate partner violence and @entity1 in pregnant Mexican XXXX : national survey results.

answer: @entity0


abstract: @entity3 ( @entity3 ) is a highly effective modality in the treatment of @entity2 of soft tissue when combined with conservative surgery. @entity3 followed by surgery is judged to have important clinical advantages over the reverse sequence. Of special significance to the treatment of the pediatric @entity0 is the observation that the treatment volume in preoperative @entity3 is nearly always smaller than in postoperative @entity3 . Precise definition of the target volume and utilization of minimum treatment volumes (i.e., reduction of the treatment volume toward the target volume to the greatest extent technically feasible) are particularly important to the improvement of functional results. Data are described for 21 @entity0 who were 21 years old or younger and were treated by @entity3 and surgery and @entity3 alone and who have been followed for 3 or more years. Local control of the treated @entity1 was achieved in all 21. Absolute figures for disease-free survival were 5 of 5 and 10 of 16 @entity0 in the 6- to 14- and 15- to 21-year age groups, respectively. Survival results according to stages for the latter group were as follows: stage I, 4 of 4; stage II, 4 of 7; and stage III, 2 of 5. All 9 @entity0 with @entity4 or @entity5 survived free of disease. The need for an effective chemotherapy regimen for @entity0 in stages IIB--III is emphasized.

title: Soft tissue XXXX (excluding rhabdomyosarcoma): radiotherapy applications.

answer: @entity2


abstract: QUESTIONS UNDER STUDY: We investigated non-malignancy-associated (     F)fluoro-deoxy-D-glucose (FDG) uptake in the @entity2 ( @entity2 ) post-treatment follow-up with positron emission tomography - computed tomography / magnetic resonance imaging (PET-CT/MRI). A retrospective study on @entity2 @entity0 undergoing follow-up or re-staging PET-CT/MRI examinations was performed. Thereby, FDG-positive regions were morphologically correlated to the CT and MRI images and a statement regarding @entity1 persistence/recurrence. METHODS: FDG-positive lesions were assessed according to their anatomical localisation and categorised as true positive, true negative, false positive or false negative findings. The gold standard for verification of an FDG-positive lesion was the cytological or histopathological examination of the region of interest. The most likely aetiology was assessed according to the following categories: (1.) physiological uptake (2.) post-surgical, inflammatory uptake, (3.) post-irradiation, inflammatory uptake and (4.) reactive, not otherwise specified. RESULTS: @entity1 recurrence / @entity1 persistence was found in 14/87 @entity0 (16.1%). A total of 159 non-malignancy-associated FDG-positive lesions were found. Every PET-CT/MRI examination revealed 2.1    1.5 FDG-positive lesions in the head and neck. A total of 107 FDG-positive lesions (67.3%) were categorised as physiological, 52 FDG-positive lesions (32.7%) as inflammatory (post-surgical: n = 14, 8.8%; post-irradiation: n = 9, 5.7%; reactive, not otherwise specified: n = 29, 18.2%). Eight @entity0 (11.8%) underwent invasive diagnostic procedures to clarify indistinct findings. CONCLUSIONS: Post-treatment follow-up of @entity2 @entity0 requires interdisciplinary management and familiarity with the @entity0 's past medical history. Awareness of common confounders of FDG positivity often allows clarification of indistinct lesions. However, a substantial number of approximately 12% of FDG-positive lesions remain unclear unless invasive diagnostic procedures are performed.

title: Post-treatment surveillance of XXXX : pitfalls in the interpretation of FDG PET-CT/MRI.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: In vivo imaging of inflammatory processes is a valuable tool in @entity5 research. We here investigated the combination of two imaging modalities in the chronic phase after @entity9 : magnetic resonance imaging (MRI) using intravenously applied ultra small supraparamagnetic iron oxide particles (USPIO), and positron emission tomography (PET) with the tracer [(11)C] @entity12 . METHODS: @entity2 were subjected to permanent @entity8 (pMCAO) by the macrosphere model and monitored by MRI and PET for 28 or 56days, followed by immunohistochemical endpoint analysis. To our knowledge, this is the first study providing USPIO-MRI data in the chronic phase up to 8weeks after @entity5 . RESULTS: Phagocytes with internalized USPIOs induced @entity10 (   ) signal alterations in the brain. Combined analysis with [(11)C] @entity12 -PET allowed quantification of phagocytic activity and other neuroinflammatory processes. From 4weeks after induction of @entity4 , @entity1 was dominated by phagocytes. Immunohistochemistry revealed colocalization of @entity11 + microglia with [(11)C] @entity12 and @entity13 / @entity7 with USPIOs. USPIO-related iron was distinguished from alternatively deposited iron by assessing MRI before and after USPIO application. Tissue affected by non-phagocytic @entity1 during the first week mostly remained in a viably vital but remodeled state after 4 or 8weeks, while phagocytic activity was associated with @entity6 and @entity3 accordingly. CONCLUSIONS: We conclude that the combined approach of USPIO-MRI and [(11)C] @entity12 -PET allows to observe post- @entity5 inflammatory processes in the living animal in an intraindividual and longitudinal fashion, predicting long-term tissue fate. The non-invasive imaging methods do not affect the immune system and have been applied to @entity0 subjects before. Translation into clinical applications is therefore feasible.

title: In vivo analysis of neuroinflammation in the late chronic phase after experimental XXXX .

answer: @entity5


abstract: BACKGROUND: In 2012, WHO changed its recommendation for intermittent preventive treatment of @entity1 during pregnancy (IPTp) from two doses to monthly doses of @entity6 - @entity5 during the second and third trimesters, but noted the importance of a cost-effectiveness analysis to lend support to the decision of policy makers. We therefore estimated the incremental cost-effectiveness of IPTp with three or more (IPTp-SP3+) versus two doses of @entity4 (IPTp-SP2). METHODS: For this analysis, we used data from a 2013 meta-analysis of seven studies in sub-Saharan Africa. We developed a decision tree model with a lifetime horizon. We analysed the base case from a societal perspective. We did deterministic and probabilistic sensitivity analyses with appropriate parameter ranges and distributions for settings with low, moderate, and high background risk of low birthweight, and did a separate analysis for @entity3 -negative @entity0 . Parameters in the model were obtained for all countries included in the original meta-analysis. We did simulations in hypothetical cohorts of 1000 pregnant @entity0 receiving either IPTp-SP3+ or IPTp-SP2. We calculated disability-adjusted life-years (DALYs) for low birthweight, severe to moderate @entity2 , and clinical @entity1 . We calculated cost estimates from data obtained in observational studies, exit surveys, and from public procurement databases. We give financial and economic costs in constant 2012 US . The main outcome measure was the incremental cost per DALY averted. FINDINGS: The delivery of IPTp-SP3+ to 1000 pregnant @entity0 averted 113  4 DALYs at an incremental cost of  825  67 producing an incremental cost-effectiveness ratio (ICER) of  7  28 per DALY averted. The results remained robust in the deterministic sensitivity analysis. In the probabilistic sensitivity analyses, the ICER was  7  7 per DALY averted for moderate risk of low birthweight,  19  4 per DALY averted for low risk, and  4  0 per DALY averted for high risk. The ICER for @entity3 -negative @entity0 was  6  2 per DALY averted. INTERPRETATION: Our findings lend strong support to the WHO guidelines that recommend a monthly dose of IPTp-SP from the second trimester onwards. FUNDING: Malaria in Pregnancy Consortium and the Bill _ Melinda Gates Foundation.

title: Cost-effectiveness of two versus three or more doses of intermittent preventive treatment for XXXX during pregnancy in sub-Saharan Africa: a modelling study of meta-analysis and cost data.

answer: @entity1


abstract: Prognosis of @entity0 with @entity1 or @entity15 can be worsened by the development of a variety of @entity4 . We describe a case of @entity19 and @entity8 in a 58-year-old @entity0 with type  C @entity15 and @entity1 hospitalized after having an elevated temperature caused by @entity7 for 2  months. The @entity3 had not been treated and daily self-administration of @entity17 had been discontinued for the previous 5  months. On day  2 of hospitalization, @entity11 and decreased blood pressure developed. Abdominal computed tomography scan revealed @entity14 , @entity12 , and @entity19 . Laparotomy revealed @entity19 and @entity8 without @entity9 and @entity19 perforation. Surgical drainage of the abscess and peritoneal cavity was performed. Immediately after the operation, upper @entity10 , shock, @entity18 , and @entity13 developed, followed by @entity16 , @entity5 , and @entity2 . @entity6 occurred on postoperative day  19. Upon autopsy, @entity8 , and @entity7 were confirmed. We surmise that untreated @entity15 and @entity1 is a risk for @entity7 that may spread in iliopsoas and free peritoneal space.

title: Psoas abscess and XXXX caused by @entity7 in a @entity0 of @entity15 and @entity1 .

answer: @entity8


abstract: Prognosis of @entity0 with @entity1 or @entity15 can be worsened by the development of a variety of @entity4 . We describe a case of @entity19 and @entity8 in a 58-year-old @entity0 with type  C @entity15 and @entity1 hospitalized after having an elevated temperature caused by @entity7 for 2  months. The @entity3 had not been treated and daily self-administration of @entity17 had been discontinued for the previous 5  months. On day  2 of hospitalization, @entity11 and decreased blood pressure developed. Abdominal computed tomography scan revealed @entity14 , @entity12 , and @entity19 . Laparotomy revealed @entity19 and @entity8 without @entity9 and @entity19 perforation. Surgical drainage of the abscess and peritoneal cavity was performed. Immediately after the operation, upper @entity10 , shock, @entity18 , and @entity13 developed, followed by @entity16 , @entity5 , and @entity2 . @entity6 occurred on postoperative day  19. Upon autopsy, @entity8 , and @entity7 were confirmed. We surmise that untreated @entity15 and @entity1 is a risk for @entity7 that may spread in iliopsoas and free peritoneal space.

title: Psoas abscess and @entity8 caused by XXXX in a @entity0 of @entity15 and @entity1 .

answer: @entity7


abstract: Prognosis of @entity0 with @entity1 or @entity15 can be worsened by the development of a variety of @entity4 . We describe a case of @entity19 and @entity8 in a 58-year-old @entity0 with type  C @entity15 and @entity1 hospitalized after having an elevated temperature caused by @entity7 for 2  months. The @entity3 had not been treated and daily self-administration of @entity17 had been discontinued for the previous 5  months. On day  2 of hospitalization, @entity11 and decreased blood pressure developed. Abdominal computed tomography scan revealed @entity14 , @entity12 , and @entity19 . Laparotomy revealed @entity19 and @entity8 without @entity9 and @entity19 perforation. Surgical drainage of the abscess and peritoneal cavity was performed. Immediately after the operation, upper @entity10 , shock, @entity18 , and @entity13 developed, followed by @entity16 , @entity5 , and @entity2 . @entity6 occurred on postoperative day  19. Upon autopsy, @entity8 , and @entity7 were confirmed. We surmise that untreated @entity15 and @entity1 is a risk for @entity7 that may spread in iliopsoas and free peritoneal space.

title: Psoas abscess and @entity8 caused by @entity7 in a @entity0 of XXXX and @entity1 .

answer: @entity15


abstract: Prognosis of @entity0 with @entity1 or @entity15 can be worsened by the development of a variety of @entity4 . We describe a case of @entity19 and @entity8 in a 58-year-old @entity0 with type  C @entity15 and @entity1 hospitalized after having an elevated temperature caused by @entity7 for 2  months. The @entity3 had not been treated and daily self-administration of @entity17 had been discontinued for the previous 5  months. On day  2 of hospitalization, @entity11 and decreased blood pressure developed. Abdominal computed tomography scan revealed @entity14 , @entity12 , and @entity19 . Laparotomy revealed @entity19 and @entity8 without @entity9 and @entity19 perforation. Surgical drainage of the abscess and peritoneal cavity was performed. Immediately after the operation, upper @entity10 , shock, @entity18 , and @entity13 developed, followed by @entity16 , @entity5 , and @entity2 . @entity6 occurred on postoperative day  19. Upon autopsy, @entity8 , and @entity7 were confirmed. We surmise that untreated @entity15 and @entity1 is a risk for @entity7 that may spread in iliopsoas and free peritoneal space.

title: Psoas abscess and @entity8 caused by @entity7 in a @entity0 of @entity15 and XXXX .

answer: @entity1


abstract: Prognosis of @entity0 with @entity1 or @entity15 can be worsened by the development of a variety of @entity4 . We describe a case of @entity19 and @entity8 in a 58-year-old @entity0 with type  C @entity15 and @entity1 hospitalized after having an elevated temperature caused by @entity7 for 2  months. The @entity3 had not been treated and daily self-administration of @entity17 had been discontinued for the previous 5  months. On day  2 of hospitalization, @entity11 and decreased blood pressure developed. Abdominal computed tomography scan revealed @entity14 , @entity12 , and @entity19 . Laparotomy revealed @entity19 and @entity8 without @entity9 and @entity19 perforation. Surgical drainage of the abscess and peritoneal cavity was performed. Immediately after the operation, upper @entity10 , shock, @entity18 , and @entity13 developed, followed by @entity16 , @entity5 , and @entity2 . @entity6 occurred on postoperative day  19. Upon autopsy, @entity8 , and @entity7 were confirmed. We surmise that untreated @entity15 and @entity1 is a risk for @entity7 that may spread in iliopsoas and free peritoneal space.

title: Psoas abscess and @entity8 caused by @entity7 in a XXXX of @entity15 and @entity1 .

answer: @entity0


abstract: AIMS/HYPOTHESIS: Sleep loss is associated with insulin resistance and an increased risk for @entity3 2 @entity1 , yet underlying mechanisms are not understood. Elevation of circulating non-esterified (i.e. free) @entity7 (NEFA) concentrations can lead to insulin resistance and plays a central role in the development of @entity4 . Circulating NEFA in healthy individuals shows a marked diurnal variation with maximum levels occurring at night, yet the impact of @entity2 on NEFA levels across the 24 h cycle remains unknown. We hypothesised that sleep restriction would alter hormones that are known to stimulate lipolysis and lead to an increase in NEFA levels. METHODS: We studied 19 healthy young @entity0 under controlled laboratory conditions with four consecutive nights of 8.5 h in bed (normal sleep) and 4.5 h in bed (sleep restriction) in randomised order. The 24 h blood profiles of NEFA, @entity10 ( @entity10 ), @entity8 ( @entity8 ), @entity6 , @entity5 and insulin were simultaneously assessed. Insulin sensitivity was estimated by a frequently sampled intravenous @entity5 tolerance test. RESULTS: Sleep restriction relative to normal sleep resulted in increased NEFA levels during the nocturnal and early-morning hours. The elevation in NEFA was related to prolonged nocturnal @entity10 secretion and higher early-morning @entity8 levels. Insulin sensitivity was decreased after sleep restriction and the @entity9 was correlated with the increase in nocturnal NEFA levels. CONCLUSIONS/INTERPRETATION: Sleep restriction in healthy @entity0 results in increased nocturnal and early-morning NEFA levels, which may partly contribute to insulin resistance and the elevated @entity1 risk associated with @entity2 .

title: Sleep restriction increases free fatty acids in healthy XXXX .

answer: @entity0


abstract: UNASSIGNED: Insertional mutagenesis (IM) by retrovirus (RV) is a high-throughput approach for interrogating gene functions in model species. Haploid cell provides a unique system for genetic screening by IM and prosperous progress has been achieved in @entity0 cells. However, little was known in lower vertebrate cells. Here, we report development of retroviral vectors (rvSAchCVgfp, rvSAchCVpf and rvSAchSTpf) and establishment of IM library in @entity3 haploid cells. Each vector contains a modified @entity1 ( @entity1 ) cassette, which could extend the mutated cell population including @entity1 insertions not in-frame or in weakly expressed genes. Virus titration determined by flow cytometry showed that rvSAchSTpf possessed the highest supernatant virus titer (1.5*10(5)TU/ml) in @entity3 haploid cell, while rvSAchCVpf produced the lowest titer (2.8*10(4)TU/ml). However, quantification of proviral DNAs in transduced cells by droplet digital PCR (ddPCR) demonstrated that the "real titer" may be similar among the three vectors. Furthermore, an IM library was established by FACS of haploid cells transduced with rvSAchCVgfp at a MOI of 0.1. A single copy RV integration in the majority of cells was confirmed by ddPCR in the library. Notably, there was a significant decrease of haploid cell percentage after FACS, suggesting potential trapping for survival/growth essential genes. Our results demonstrated successful development of retroviral vectors for IM in @entity3 haploid cells, serving for haploid genetic screening of host factors for @entity2 and genes underlying certain cellular processes in fish model.

title: Development of retroviral vectors for insertional mutagenesis in XXXX haploid cells.

answer: @entity3


abstract: INTRODUCTION: @entity2 turns into a chronic disease. Its impact on @entity0 's daily life may require the assistance of caregiver. AIMS: To explore the experiences of main caregivers (MCs) helping @entity0 suffering from @entity1 ( @entity1 ), and to explore the role and the position assigned to general practitioners (GPs). METHOD: Qualitative study using semi-directive interviews with 13  PCs, recruited in Roanne's hospital and the @entity2 Institute Lucien-Neuwirth (Rh  ne-Alpes), conducted from February to May 2014. RESULTS: MCs' life was affected on a social, family, and professional level. Despite a need of listening and support, they remained behind, by devotion. GPs' were care managers, and were found out empathic, compassionate and reassuring. Present at the @entity2 announcement and viewed as an actor at the end of life, their functions were variable, following MCs during the treatment phase. During this phase, some of them perceived that lack of time, expertise and/or information seemed to be an obstacle to their solicitations. CONCLUSION: GPs' regular care could improve MCs' quality of life. Telemedicine could facilitate communication between GPs and hospital staff asked by the MCs.

title: [Experiences of main caregivers helping @entity0 suffering from XXXX and position assigned to general practitioners.]

answer: @entity1


abstract: INTRODUCTION: @entity2 turns into a chronic disease. Its impact on @entity0 's daily life may require the assistance of caregiver. AIMS: To explore the experiences of main caregivers (MCs) helping @entity0 suffering from @entity1 ( @entity1 ), and to explore the role and the position assigned to general practitioners (GPs). METHOD: Qualitative study using semi-directive interviews with 13  PCs, recruited in Roanne's hospital and the @entity2 Institute Lucien-Neuwirth (Rh  ne-Alpes), conducted from February to May 2014. RESULTS: MCs' life was affected on a social, family, and professional level. Despite a need of listening and support, they remained behind, by devotion. GPs' were care managers, and were found out empathic, compassionate and reassuring. Present at the @entity2 announcement and viewed as an actor at the end of life, their functions were variable, following MCs during the treatment phase. During this phase, some of them perceived that lack of time, expertise and/or information seemed to be an obstacle to their solicitations. CONCLUSION: GPs' regular care could improve MCs' quality of life. Telemedicine could facilitate communication between GPs and hospital staff asked by the MCs.

title: [Experiences of main caregivers helping XXXX suffering from @entity1 and position assigned to general practitioners.]

answer: @entity0


abstract: BACKGROUND AND OBJECTIVES: Some topics in the clinical management of regional anesthesia in @entity0 remain controversial. To evaluate and come to a consensus regarding some of these topics, The European Society of Regional Anaesthesia and @entity1 Therapy (ESRA) and the American Society of Regional Anesthesia and @entity1 Medicine (ASRA) developed a joint committee practice advisory on pediatric regional anesthesia (PRA). METHODS: Representatives from both ASRA and ESRA comprised the joint committee practice advisory on PRA. Evidence-based recommendations were based on a systematic search of the literature. In cases where no literature was available, expert opinion was elicited. Experts selected controversial topics in PRA. RESULTS: The performance of PRA under general anesthesia or deep sedation is associated with acceptable safety and should be viewed as the standard of care (Evidence B2 and Evidence B3). Because of the difficulty interpreting a negative test dose, the use of test dosing should remain discretionary (Evidence B4). The use of either air-loss of resistance or saline-loss of resistance techniques is supported by expert opinion, but the literature supporting one technique over the other is sparse and controversial; when used appropriately, each technique may be safely used in @entity0 . There are no current evidence-based data that the use of RA increases the risk for @entity2 or delays its diagnosis in @entity0 . CONCLUSIONS: High-level evidence is not yet available for the topics evaluated, and most recommendations are based on Evidence B studies. The ESRA/ASRA recommendations intend to provide guidance for the safe practice of regional anesthesia in @entity0 .

title: The European Society of Regional Anaesthesia and XXXX Therapy and the American Society of Regional Anesthesia and @entity1 Medicine Joint Committee Practice Advisory on Controversial Topics in Pediatric Regional Anesthesia.

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: Some topics in the clinical management of regional anesthesia in @entity0 remain controversial. To evaluate and come to a consensus regarding some of these topics, The European Society of Regional Anaesthesia and @entity1 Therapy (ESRA) and the American Society of Regional Anesthesia and @entity1 Medicine (ASRA) developed a joint committee practice advisory on pediatric regional anesthesia (PRA). METHODS: Representatives from both ASRA and ESRA comprised the joint committee practice advisory on PRA. Evidence-based recommendations were based on a systematic search of the literature. In cases where no literature was available, expert opinion was elicited. Experts selected controversial topics in PRA. RESULTS: The performance of PRA under general anesthesia or deep sedation is associated with acceptable safety and should be viewed as the standard of care (Evidence B2 and Evidence B3). Because of the difficulty interpreting a negative test dose, the use of test dosing should remain discretionary (Evidence B4). The use of either air-loss of resistance or saline-loss of resistance techniques is supported by expert opinion, but the literature supporting one technique over the other is sparse and controversial; when used appropriately, each technique may be safely used in @entity0 . There are no current evidence-based data that the use of RA increases the risk for @entity2 or delays its diagnosis in @entity0 . CONCLUSIONS: High-level evidence is not yet available for the topics evaluated, and most recommendations are based on Evidence B studies. The ESRA/ASRA recommendations intend to provide guidance for the safe practice of regional anesthesia in @entity0 .

title: The European Society of Regional Anaesthesia and @entity1 Therapy and the American Society of Regional Anesthesia and XXXX Medicine Joint Committee Practice Advisory on Controversial Topics in Pediatric Regional Anesthesia.

answer: @entity1


abstract: BACKGROUND:: The @entity3 Research Society International recommended that nonpharmacological methods include @entity0 education programs, @entity2 , coping strategies, and exercise programs for the management of @entity4 ( @entity3 ). However, neither systematic review nor meta-analysis has been published regarding the effectiveness of home exercise programs for the management of knee @entity3 . PURPOSE:: The purpose of this systematic review was to examine the evidence regarding the effect of home exercise programs with and without supervised clinic-based exercises in the management of knee @entity3 . METHODS:: We searched PubMed, CINAHL, Embase, Scopus, and PEDro for research articles published prior to September 2014 using the key words such as @entity1 , exercise, home exercise program, rehabilitation, supervised exercise program, and physiotherapy in combination with Medical Subject Headings " @entity3 knee." We selected randomized and case-controlled trials published in English language. To verify the quality of the selected studies, we applied the PEDro Scale. Two evaluators individually selected the studies based on titles, excluding those articles that were not related to the objectives of this review. One evaluator extracted data from the included studies. A second evaluator independently verified extracted data for accuracy. RESULTS:: A total of 31 studies were found in the search. Of these, 19 studies met the inclusion criteria and were further analyzed. Seventeen of these 19 studies reached high methodological quality on the PEDro scale. Although the methods and home exercise program interventions varied widely in these studies, most found significant improvements in @entity1 and function in individuals with knee @entity3 . DISCUSSIONS:: The analysis indicated that both home exercise programs with and without supervised clinic-based exercises were beneficial in the management of knee @entity3 . CONCLUSIONS:: The large evidence of high-quality trials supports the effectiveness of home exercise programs with and without supervised clinic-based exercises in the rehabilitation of knee @entity3 . In addition, small but growing evidence supports the effectiveness of other types of exercise such as tai chi, balance, and proprioceptive training for individuals with knee @entity3 .

title: Effect of Home Exercise Program in @entity0 With XXXX : A Systematic Review and Meta-analysis.

answer: @entity4


abstract: BACKGROUND:: The @entity3 Research Society International recommended that nonpharmacological methods include @entity0 education programs, @entity2 , coping strategies, and exercise programs for the management of @entity4 ( @entity3 ). However, neither systematic review nor meta-analysis has been published regarding the effectiveness of home exercise programs for the management of knee @entity3 . PURPOSE:: The purpose of this systematic review was to examine the evidence regarding the effect of home exercise programs with and without supervised clinic-based exercises in the management of knee @entity3 . METHODS:: We searched PubMed, CINAHL, Embase, Scopus, and PEDro for research articles published prior to September 2014 using the key words such as @entity1 , exercise, home exercise program, rehabilitation, supervised exercise program, and physiotherapy in combination with Medical Subject Headings " @entity3 knee." We selected randomized and case-controlled trials published in English language. To verify the quality of the selected studies, we applied the PEDro Scale. Two evaluators individually selected the studies based on titles, excluding those articles that were not related to the objectives of this review. One evaluator extracted data from the included studies. A second evaluator independently verified extracted data for accuracy. RESULTS:: A total of 31 studies were found in the search. Of these, 19 studies met the inclusion criteria and were further analyzed. Seventeen of these 19 studies reached high methodological quality on the PEDro scale. Although the methods and home exercise program interventions varied widely in these studies, most found significant improvements in @entity1 and function in individuals with knee @entity3 . DISCUSSIONS:: The analysis indicated that both home exercise programs with and without supervised clinic-based exercises were beneficial in the management of knee @entity3 . CONCLUSIONS:: The large evidence of high-quality trials supports the effectiveness of home exercise programs with and without supervised clinic-based exercises in the rehabilitation of knee @entity3 . In addition, small but growing evidence supports the effectiveness of other types of exercise such as tai chi, balance, and proprioceptive training for individuals with knee @entity3 .

title: Effect of Home Exercise Program in XXXX With @entity4 : A Systematic Review and Meta-analysis.

answer: @entity0


abstract: BACKGROUND: @entity4 is a @entity5 that may affect any organ of the body. The most frequent loci of manifestation are the lungs. However, there are individual cases where bones are affected. The literature describes cases in which swelling or @entity3 were the first findings of a @entity1 . This is the first case reporting an @entity6 in both angles of the mandibles which led to the diagnosis of @entity4 with multi-organ involvement. CASE PRESENTATION: The authors present a 74  years old European female @entity0 without previous diagnosis of @entity4 who presented with @entity2 in the area of the jaw angles. There were no further clinical symptoms. Bone biopsy following radiological investigation demonstrated non-caseating @entity5 consistent with @entity4 of the bone. Further evaluation confirmed multi-organ disease with involvement of lungs, intrathoracic lymph nodes, and the central nervous system. CONCLUSION: This case report shows that diagnosis of a severe disease can be missed if systematic clinical signs are not given. Furthermore, an accurate anamnesis and examination is required to receive an early diagnosis which often needs an interdisciplinary approach.

title: XXXX of unknown origin: a case report.

answer: @entity6


abstract: BACKGROUND: As part of a project aimed at developing oviposition attractants for the control and surveillance of Phlebotomus papatasi (a vector of Old-World @entity2 ), we tested the hypothesis that gravid sand flies are attracted to chemical cues emanating from the growth medium of conspecific larvae - predominantly larvae-conditioned host feces that represents a suitable oviposition site. We report the results of a systematic assessment of media from various developmental stages of the sand @entity1 using oviposition and olfactometer behavioral assays. METHODS: We conducted multiple-choice oviposition assays in 500  mL Nalgene jars. Six treatments were placed on separate filter paper discs at the bottom of the jar: 2(nd)/3(rd) larval instar medium, 4(th) larval instar/pupae medium, frass from expired colonies, larval food (aged @entity0 chow and @entity0 feces mix), @entity0 feces, and a solvent (water) control. Fifty gravid females were introduced into each jar. Cumulative number of eggs laid on each filter paper per jar was counted at different time intervals from digital images. Attraction of gravid sand flies to these six treatments was assayed with a 3-chamber linear olfactometer. Twenty gravid females were transferred to the middle chamber of the olfactometer and their distribution in treatment and control chambers was recorded after 3  h. RESULTS: Almost no eggs were oviposited during the first 72  h following a blood-meal. Cumulative egg deposition increased drastically in the next 24  h (hours 73-96), with a slight non-significant increasing trend thereafter. Comparing mean cumulative egg deposition among the six treatments, we found that significantly more eggs were oviposited on 2(nd)/3(rd) larval rearing medium followed by 4(th) instar/pupae rearing medium. Oviposition preference did not vary over time. The olfactometer results were consistent with the oviposition assays, with 2(nd)/3(rd) larval rearing medium being the most attractive, followed by 4(th) instar/pupae rearing medium. CONCLUSION: The key finding of this study is that gravid, laboratory reared, Ph. papatasi sand flies are significantly more attracted to rearing medium of the most biologically active larval stages (2(nd)/3(rd) instar and 4(th) instar/pupae). This finding indicates that sand @entity1 -digested host food and feces is attractive to gravid females and suggests that the larvae and larval gut microbiome may be involved in conditioning the oviposition substrate and possibly the production of oviposition attractants and stimulants.

title: Attraction and oviposition preferences of Phlebotomus papatasi (Diptera: Psychodidae), vector of Old-World XXXX , to larval rearing media.

answer: @entity2


abstract: UNASSIGNED: A 12 yr old castrated male domestic longhair underwent renal transplantation for treatment of chronic @entity7 . Full-thickness intestinal biopsies obtained prior to transplantation revealed mild @entity6 . Twelve months following transplantation, the @entity0 underwent surgery for resection of a mesenteric mass causing @entity3 . The mesenteric mass was resected and an intestinal resection and @entity1 was performed. Extended-spectrum-b-lactamase producing @entity9 was cultured from the resected tissue and urinary tract. Bacterial rods were noted to be circulating in the bloodstream, causing @entity2 . Despite aggressive treatment of the @entity3 and @entity2 using surgical debridement, drain placement, aggressive antibiotic therapy with IV meropenem, and vasopressor support, the @entity0 succumbed to persistent @entity4 and suffered @entity5 . Extended-spectrum-b-lactamase-producing bacteria are of growing concern in @entity0 and veterinary medicine, maintaining susceptibility often only to @entity8 and @entity10 antibiotics. Resistance to even those antibiotics is emerging. Veterinary @entity0 with a history of antibiotic therapy, central venous or urinary catheterization, immunosuppression, enteric surgery, and an extended stay in the intensive care unit may be predisposed.

title: XXXX and Infection due to ESBL-producing @entity9 Following Feline Renal Allograft Transplantation.

answer: @entity2