abstract: The objective of this study was to compare the recovery of male @entity0 after a major abdominal surgical procedure (the implantation of a radiotelemetry transmitter) when treated with @entity4 , @entity6 , or @entity5 and subcutaneous fluids (5% @entity2 ) or with subcutaneous fluids only. The parameters for assessing recovery were heart rate (HR), mean arterial blood pressure (MAP), home cage activity, food and water consumption, and body weight. HR, MAP, and activity were continuously monitored by radiotelemetry methods, food and water intakes were determined daily, and body weights were measured once or three times a week. In light of HR, nocturnal home cage activity, water consumption, and body @entity3 , animals were recovered by about 7 days after surgery. MAP normalized by 1 to 2 days postsurgery, and food consumption returned to presurgical levels 5 to 12 days after surgery, depending on the analgesic treatment. On the basis of nocturnal activity, HR, and food and water intakes, @entity4 -treated animals recovered more slowly than did the other two analgesic-treated groups. By the other parameters, all three analgesic-treated groups showed very similar responses across time. Surprisingly, when compared with the groups receiving only subcutaneous fluids, @entity4 and @entity6 delayed or did not advance recovery, whereas @entity5 neither retarded nor advanced recovery. Explanations for these results include: (a) the analgesics were effective in relieving @entity1 but had pharmacological side effects that altered the measured parameters, making it difficult to determine recovery; (b) the level of @entity1 experienced did not notably affect recovery; (c) the analgesics, at the doses and/or dosing schedules used, were not effective in the relief of @entity1 , thereby causing both groups of animals to recover at the same rate; and (d) the analgesics interfered with recovery. Final resolution of these issues awaits further investigation.

title: Recovery of male XXXX from major abdominal surgery after treatment with various analgesics.

answer: @entity0


abstract: BACKGROUND: A systematic review of prospective controlled clinical trials was performed to assess the effectiveness of physical therapy interventions for the prevention and treatment of @entity2 . @entity3 has an impact on daily life for many @entity0 . Prevention and @entity2 is therefore an important issue for all those concerned with @entity0 's health. METHODS: All prospective controlled clinical trials retrieved by systematic searching of electronic databases, checking of reference lists and contacting of authors were examined. Two reviewers independently selected trials for inclusion and independently assessed the internal validity of the included trials. Authors were contacted to obtain missing information. RESULTS: Nine trials with a total of 1350 @entity0 were reviewed. Except for three high-quality studies, the validity of the trials was moderate to low. Two high-quality studies showed no difference in @entity1 intensity and functional status between the exercise groups and the control groups. In the third high-quality study significant reduction in sick leave was found in favor of water gymnastics compared with no intervention. Because the included trials were considered heterogeneous with regard to study design, population intervention and outcome, no meta-analysis was performed. CONCLUSIONS: Because of heterogeneity and the varying quality of the studies no strong evidence exists concerning the effect of physical therapy interventions on the prevention and @entity2 related to pregnancy. Future studies should meet current methodological standards, and interventions to be evaluated should be based on established theoretical framework.

title: Physical therapy for pregnancy-related XXXX : a systematic review.

answer: @entity3


abstract: PURPOSE: To report a case of @entity17 associated with cutaneous @entity6 (MM) and non-pigmented nodular @entity1 after a 10-year recurrence-free interval. METHODS: Case report with long-term follow-up of 11 years. Ocular examinations included best-corrected visual acuity (ETDRS charts), fundus photography, @entity7 angiography, and computer-assisted perimetry. In addition, human leukocyte antigen (HLA) typing was performed. RESULTS: A 48-year-old white female @entity0 developed @entity17 5 years after she had undergone surgical treatment of a superficial spreading @entity6 on her back in 1991. The first symptoms were @entity14 followed by growth of non-pigmented hair after 8 months. In our clinic, she presented 18 months later with cells and opacification in the vitreous, a macular and @entity15 and @entity3 of the @entity8 ( @entity8 ). The anterior segment showed endothelial precipitates of the @entity5 , and a progressive secondary @entity4 . Fluorescein angiography detected a bilateral @entity9 and the optic disc, and focal leakage in the @entity8 level. During follow-up the @entity0 developed more cutaneous signs, such as @entity13 and @entity18 . A non-pigmented lymph node MM @entity1 was diagnosed after a 10-year disease-free interval. HLA typing was positive for @entity10 *01, @entity10 *24, @entity11 *08, @entity11 *39, @entity12 *03, and @entity12 *11. CONCLUSION: Our findings suggest that the described ocular findings of @entity17 may represent a component of a syndrome consisting also of @entity6 -associated @entity16 . Within the framework of current concepts of immunity in @entity0 with MM and VKH, the long recurrence-free interval might support the hypothesis of an autoimmune or @entity2 process against melanocytes. The use of immunosuppressive therapy in the treatment of VKH and its potential influence on the development of @entity1 should be carefully reconsidered.

title: @entity17 associated with XXXX : an 11-year follow-up.

answer: @entity6


abstract: PURPOSE: To report a case of @entity17 associated with cutaneous @entity6 (MM) and non-pigmented nodular @entity1 after a 10-year recurrence-free interval. METHODS: Case report with long-term follow-up of 11 years. Ocular examinations included best-corrected visual acuity (ETDRS charts), fundus photography, @entity7 angiography, and computer-assisted perimetry. In addition, human leukocyte antigen (HLA) typing was performed. RESULTS: A 48-year-old white female @entity0 developed @entity17 5 years after she had undergone surgical treatment of a superficial spreading @entity6 on her back in 1991. The first symptoms were @entity14 followed by growth of non-pigmented hair after 8 months. In our clinic, she presented 18 months later with cells and opacification in the vitreous, a macular and @entity15 and @entity3 of the @entity8 ( @entity8 ). The anterior segment showed endothelial precipitates of the @entity5 , and a progressive secondary @entity4 . Fluorescein angiography detected a bilateral @entity9 and the optic disc, and focal leakage in the @entity8 level. During follow-up the @entity0 developed more cutaneous signs, such as @entity13 and @entity18 . A non-pigmented lymph node MM @entity1 was diagnosed after a 10-year disease-free interval. HLA typing was positive for @entity10 *01, @entity10 *24, @entity11 *08, @entity11 *39, @entity12 *03, and @entity12 *11. CONCLUSION: Our findings suggest that the described ocular findings of @entity17 may represent a component of a syndrome consisting also of @entity6 -associated @entity16 . Within the framework of current concepts of immunity in @entity0 with MM and VKH, the long recurrence-free interval might support the hypothesis of an autoimmune or @entity2 process against melanocytes. The use of immunosuppressive therapy in the treatment of VKH and its potential influence on the development of @entity1 should be carefully reconsidered.

title: XXXX associated with @entity6 : an 11-year follow-up.

answer: @entity17


abstract: We analyzed outcomes and prognostic factors to assess the value of reirradiation for recurrent @entity2 . Forty-four @entity0 with recurrent @entity3 had undergone external beam reirradiation with cumulative dosing of more than 80 Gy. Six and 38 cases exhibited recurrent stage III and stage IV @entity1 , respectively. The complete response rate was 32%. Median relapse-free survival time was 4 months, and the 5-year survival was 6%. The major prognostic factor was anatomical location (p < 0.0001). Favorable sites were the nasopharynx, larynx, or oropharynx; unfavorable sites were the oral cavity, nasal cavity, or hypopharynx. Poorly differentiated @entity1 , no prior surgery, cumulative dose more than 125 Gy, and overlapping field less than 40 cm2 between the initial and reirradiation fields were also favorable factors. Multivariate analysis revealed that anatomical location and overlapping field were significant (0.001 and 0.019, respectively) in relapse-free survival. On exclusion of anatomical location from the analysis, history of prior surgery, and cumulative dose were significant (p = 0.002 and p = 0.023, respectively). Severe late complications occurred in only 1 of 14 (7%) @entity0 followed up for longer than 1 year. Reirradiation would be indicative for nasopharyngeal, oropharyngeal, or @entity1 with small overlapping field, or @entity1 receiving a cumulative dose more than 125 Gy without prior surgery.

title: Prognostic factors of reirradiation for recurrent XXXX .

answer: @entity2


abstract: An outbreak of acute @entity3 occurring in 4 members of the same family, two @entity0 , a @entity0 and a male, is reported. The index case presented acute respiratory symptoms, severe enough to require hospitalization. In the remaining @entity0 , the infection was asymptomatic but was evidenced by reactive histoplasmin serologic tests. Search for the common source of infection led to an enriched soil obtained in a local nursery for growing in-door plants. BALB/c @entity1 were inoculated with suspensions of soils from the potted plants. @entity2 . capsulatum was isolated from various internal organs of the @entity1 . Although @entity3 is observed more frequently in @entity0 with occupations implying risk of exposure and is connected to rural areas, outbreaks and intra-family cases are now common in urban areas. This is due to massive urbanization, deforestation, demolitions and the use of soils enriched with organic compounds, mainly bird/bat excrements. This report calls the attention on the danger involved in using such enriched soils for plant nutrition.

title: [Outbreak of acute XXXX in a family group: identification of the infection source].

answer: @entity3


abstract: The @entity7 is characterised by systemic proliferation of non-neoplastic histiocytes showing haemophagocytosis resulting in @entity10 . It has been described in relation to several viruses earlier. We present three @entity0 with @entity7 (HFS) secondary to @entity13 ( @entity13 ) confirmed by standard laboratory tests. The @entity0 were hospitalized at the University Hospital (Hospital Universitario Ram  n Gonz  lez Valencia-HURGV) in Bucaramanga, Colombia, during the past two years. They were all school-aged @entity0 who presented @entity13 with intense @entity5 , prolonged @entity1 , @entity6 and painful @entity3 . Laboratory tests showed @entity8 , @entity4 and @entity9 . A @entity12 was observed in the abdominal ultrasonography, and all @entity2 showed that platelets, red and white blood cells were phagocyted by histiocytes. According to the International Society of Histiocytosis, @entity15 is defined and classified in three major categories; the reported cases corresponded to histiocytosis class II, specifically to secondary @entity15 . Diverse associations of this @entity11 and some other non-infectious diseases. A difference has been established between primary @entity15 and secondary @entity15 . Finally, we emphasize that these three @entity0 had an atypical evolution of @entity14 , being prolonged @entity1 and persistent @entity5 the most important symptoms. The authors recommend that a @entity2 should be carried out as part of the differential diagnosis study in prolonged @entity1 associated with dengue, as there is a possibility that this complication could be secondary @entity15 .

title: [Hemophagocytic syndrome associated with XXXX ].

answer: @entity13


abstract: Numerous studies have documented the presence of racial disparities among Americans in health outcomes with respect to @entity4 , @entity0 mortality, @entity1 , and @entity3 . With @entity3 , these disparities are more dramatic. African, Hispanic, and Native Americans have the highest risks of @entity6 ( @entity6 ). The incidence of @entity6 is four times higher in African Americans than in whites. Diseases causing @entity6 , such as @entity2 , @entity5 , @entity8 , and @entity0 @entity7 virus-associated @entity3 , are particularly prevalent among African-American @entity0 . In addition to the higher prevalence, the morbidity associated with kidney complications of these diseases appears worse in African-American @entity0 . African Americans also have worse outcomes and a relatively reduced access to kidney transplantation--the best therapy for @entity6 . It is highly likely that social and environmental factors play a very significant role in the persistence of these disparities. A detailed understanding of these socioeconomic and environmental factors will be critical in formulating rational public health strategies to redress these disparities. This paper reviews the social, economic and environmental factors that impact on the incidence of @entity6 in minority groups.

title: Race and XXXX : role of social and environmental factors.

answer: @entity3


abstract: The earliest passage of the @entity0 @entity3 cell line, MeWo-A, consists of ten cell types that can be distinguished on the basis of chromosome markers. Two of these cell types have chromosomes with long @entity4 ( @entity4 ) containing sequences derived from the short arm of a chromosome #15. In one cell type the @entity4 is found on a chromosome #15 and in the other it is on a der(15;10)- @entity4 chromosome. Four other cell types were identifiable by morphologic differences of the short arm of chromosome #13, whereas, the four remaining cell types were identifiable by the presence of prominent satellites on other chromosomes. This study was directed at assessing the relative @entity5 properties of the different cell types by injecting different numbers of cells intraperitoneally, subcutaneously, or intravenously into Balb/c @entity2 . The @entity1 and nodules that developed in the peritoneal cavity and lungs were explanted into tissue culture. One hundred metaphase chromosome spreads from each established cell line were analyzed cytogenetically to detect changes in proportions of the different cell types. The cell type containing the der(15;10)- @entity4 chromosome was present in only 20% of the cells injected, but increased in proportion to between 28% and 98% after growth in @entity2 . Although the degree of selection of the der(15;10)- @entity4 -containing cell type was influenced by the number of cells injected, the consistent selection of these cells strongly suggests that this cell type has a growth advantage. Because the 15- @entity4 -containing cell type rarely increased in proportion, it is likely that the @entity4 by itself can not confer the enhanced @entity5 phenotype but requires the expression of other sequences present on other MeWo chromosomes to provide the selective growth advantage to the cells in which it is found.

title: Tumorigenicity of ten karyotypically distinct cell types present in the @entity0 XXXX cell line MeWo-A.

answer: @entity3


abstract: The earliest passage of the @entity0 @entity3 cell line, MeWo-A, consists of ten cell types that can be distinguished on the basis of chromosome markers. Two of these cell types have chromosomes with long @entity4 ( @entity4 ) containing sequences derived from the short arm of a chromosome #15. In one cell type the @entity4 is found on a chromosome #15 and in the other it is on a der(15;10)- @entity4 chromosome. Four other cell types were identifiable by morphologic differences of the short arm of chromosome #13, whereas, the four remaining cell types were identifiable by the presence of prominent satellites on other chromosomes. This study was directed at assessing the relative @entity5 properties of the different cell types by injecting different numbers of cells intraperitoneally, subcutaneously, or intravenously into Balb/c @entity2 . The @entity1 and nodules that developed in the peritoneal cavity and lungs were explanted into tissue culture. One hundred metaphase chromosome spreads from each established cell line were analyzed cytogenetically to detect changes in proportions of the different cell types. The cell type containing the der(15;10)- @entity4 chromosome was present in only 20% of the cells injected, but increased in proportion to between 28% and 98% after growth in @entity2 . Although the degree of selection of the der(15;10)- @entity4 -containing cell type was influenced by the number of cells injected, the consistent selection of these cells strongly suggests that this cell type has a growth advantage. Because the 15- @entity4 -containing cell type rarely increased in proportion, it is likely that the @entity4 by itself can not confer the enhanced @entity5 phenotype but requires the expression of other sequences present on other MeWo chromosomes to provide the selective growth advantage to the cells in which it is found.

title: Tumorigenicity of ten karyotypically distinct cell types present in the XXXX @entity3 cell line MeWo-A.

answer: @entity0


abstract: OBJECTIVE: To investigate the proliferative characteristics of fibroblasts cultured from emphysematous lungs. METHODS: Fibroblasts were isolated and cultured from emphysematous lungs surgically resected as a consequence of lung volume reduction surgery and from non-cancerous areas of lungs obtained following resection for @entity0 as a non-emphysematous control. Their proliferative activities were compared, as was the effect of @entity2 ( @entity2 ) on fibroblast proliferation. After incubation with various concentrations of @entity2 , cells were harvested and cell numbers were counted. Growth curves were constructed and doubling time was calculated to compare the proliferative activity of fibroblasts from emphysematous and @entity1 . RESULTS: The proliferation of fibroblasts from emphysematous lungs cultured with normal medium appeared suppressed compared with @entity1 . The addition of @entity2 to the medium induced more obvious growth inhibition in emphysematous lung fibroblasts. The growth of both fibroblast cultures was inhibited by @entity2 and this appeared to be concentration dependent. CONCLUSIONS: Fibroblasts from emphysematous lungs had lower proliferative activity and were more susceptible to cigarette smoke than those from @entity1 . Cigarette smoke may play a critical role in the development and deterioration of @entity3 by suppressing the growth of lung fibroblasts.

title: Cigarette smoke inhibits the growth of lung fibroblasts from patients with XXXX .

answer: @entity3


abstract: The reference standard for identifying @entity2 and @entity3 is a pneumotachograph, but using this can disrupt sleep. Nasal airflow estimation by measuring nasal pressure via nasal prongs is better tolerated by @entity0 . However, nasal pressure has not been validated, using an event-by-event analysis, for detecting @entity1 . Eleven @entity0 undergoing polysomnography wore a nasal mask capable of measuring nasal airflow (via pneumotachograph) and nasal pressure simultaneously. Each study was screened for @entity4 , and from these 550 were randomly selected and blindly scored as an @entity2 / @entity3 or no event each using the pneumotachograph, nasal pressure, square root nasal pressure, and respiratory inductance sum signals independently. Agreement was measured using Cohen's kappa statistic. Intermeasurement agreements between the pneumotachograph and nasal pressure, square root nasal pressure, and respiratory inductance plethysmography sum were 0.76, 0.73, and 0.50, respectively. Inter- and intrarater agreements were, respectively, 0.68 and 0.60 for the pneumotachograph, 0.66 and 0.82 for nasal pressure, 0.61 and 0.78 for square root nasal pressure, and 0.47 and 0.76 for respiratory inductance plethysmography sum. These results indicate that nasal pressure has excellent agreement compared with a pneumotachograph and very good inter-/intrarater agreement. Square root transformation of the nasal pressure signal does not improve these levels of agreement, indicating that it is unnecessary in routine clinical practice for scoring @entity2 / @entity3 .

title: Validation of nasal pressure for the identification of XXXX .

answer: @entity1


abstract: We have identified a potential serum marker for @entity6 ( @entity6 ) using microarray analysis from samples of @entity6 . We compared the gene expression profile of 19 @entity3 to pooled normal brain by competitive hybridization of RNA from each @entity2 sample to a pooled sample of RNA isolated from normal brain tissue using the Incyte 10,000 gene expression array. The most differentially expressed gene in this analysis encodes a secreted glycoprotein and is referred to as @entity9 . @entity9 mRNA was detected in the @entity6 samples with a range of 3- to 62-fold elevation over normal brain. It has been reported previously that this protein is expressed in pathologic conditions of extracellular matrix degradation and angiogenesis, such as @entity5 , severe @entity7 , @entity8 , primary @entity4 , and metastatic @entity0 . These data suggest @entity9 may be involved in extracellular matrix degradation and/or angiogenesis. Western blot analysis of @entity3 samples for @entity9 protein levels revealed substantial elevation in approximately 65% of GBMs and undetectable levels in lower-grade @entity3 (grade II and III) or normal brain tissue. We performed ELISA analysis on serum samples of @entity3 @entity1 to determine whether this protein would correlate with the presence of @entity2 and @entity2 grade or burden. @entity9 serum levels were substantially elevated in many of the @entity6 @entity1 . Statistical analysis of these data indicates that in @entity1 with @entity3 , serum @entity9 levels correlate with @entity2 grade and potentially @entity2 burden in @entity6 .

title: Gene expression microarray analysis reveals XXXX to be a potential serum marker for malignant character in @entity1 @entity3 .

answer: @entity9


abstract: We have identified a potential serum marker for @entity6 ( @entity6 ) using microarray analysis from samples of @entity6 . We compared the gene expression profile of 19 @entity3 to pooled normal brain by competitive hybridization of RNA from each @entity2 sample to a pooled sample of RNA isolated from normal brain tissue using the Incyte 10,000 gene expression array. The most differentially expressed gene in this analysis encodes a secreted glycoprotein and is referred to as @entity9 . @entity9 mRNA was detected in the @entity6 samples with a range of 3- to 62-fold elevation over normal brain. It has been reported previously that this protein is expressed in pathologic conditions of extracellular matrix degradation and angiogenesis, such as @entity5 , severe @entity7 , @entity8 , primary @entity4 , and metastatic @entity0 . These data suggest @entity9 may be involved in extracellular matrix degradation and/or angiogenesis. Western blot analysis of @entity3 samples for @entity9 protein levels revealed substantial elevation in approximately 65% of GBMs and undetectable levels in lower-grade @entity3 (grade II and III) or normal brain tissue. We performed ELISA analysis on serum samples of @entity3 @entity1 to determine whether this protein would correlate with the presence of @entity2 and @entity2 grade or burden. @entity9 serum levels were substantially elevated in many of the @entity6 @entity1 . Statistical analysis of these data indicates that in @entity1 with @entity3 , serum @entity9 levels correlate with @entity2 grade and potentially @entity2 burden in @entity6 .

title: Gene expression microarray analysis reveals @entity9 to be a potential serum marker for malignant character in @entity1 XXXX .

answer: @entity3


abstract: We have identified a potential serum marker for @entity6 ( @entity6 ) using microarray analysis from samples of @entity6 . We compared the gene expression profile of 19 @entity3 to pooled normal brain by competitive hybridization of RNA from each @entity2 sample to a pooled sample of RNA isolated from normal brain tissue using the Incyte 10,000 gene expression array. The most differentially expressed gene in this analysis encodes a secreted glycoprotein and is referred to as @entity9 . @entity9 mRNA was detected in the @entity6 samples with a range of 3- to 62-fold elevation over normal brain. It has been reported previously that this protein is expressed in pathologic conditions of extracellular matrix degradation and angiogenesis, such as @entity5 , severe @entity7 , @entity8 , primary @entity4 , and metastatic @entity0 . These data suggest @entity9 may be involved in extracellular matrix degradation and/or angiogenesis. Western blot analysis of @entity3 samples for @entity9 protein levels revealed substantial elevation in approximately 65% of GBMs and undetectable levels in lower-grade @entity3 (grade II and III) or normal brain tissue. We performed ELISA analysis on serum samples of @entity3 @entity1 to determine whether this protein would correlate with the presence of @entity2 and @entity2 grade or burden. @entity9 serum levels were substantially elevated in many of the @entity6 @entity1 . Statistical analysis of these data indicates that in @entity1 with @entity3 , serum @entity9 levels correlate with @entity2 grade and potentially @entity2 burden in @entity6 .

title: Gene expression microarray analysis reveals @entity9 to be a potential serum marker for malignant character in XXXX @entity3 .

answer: @entity1


abstract: BACKGROUND AND PURPOSE: Earlier, we found that @entity1 @entity0 with > or =1 asymptomatic @entity4 on CT had @entity7 and @entity3 significantly more often than @entity0 without such lesions, and we hypothesized that 2 types of @entity5 could be distinguished during life: @entity6 and microatheromatosis, respectively. Differences in prognosis might sustain this hypothesis of 2 @entity1 entities. Therefore, we performed a follow-up in 333 @entity0 with first @entity1 , distinguishing those with > or =1 asymptomatic @entity2 ( @entity8 +) from those without such lesions ( @entity8 -). METHODS: Cross-sectional follow-up was performed after 785+/-479 days (mean+/-SD) in 104 @entity8 + @entity0 and 865+/-545 days in 229 @entity8 - @entity0 . RESULTS: Mortality at the end of follow-up was 33% in @entity8 + and 21% in @entity8 - @entity0 [odds ratio (OR), 1.74; 95% confidence interval (CI), 1.01 to 3.01]. @entity1 recurrence rate was 21% in @entity8 + and 11% in @entity8 - (OR, 2.09; 95% CI, 1.08 to 4.06). Forty percent of @entity8 + and 26% of @entity8 - @entity0 had unfavorable outcome at the end of follow-up (OR, 1.95; 95% CI, 1.17 to 3.26). Kaplan-Meier curves showed less favorable survival in @entity8 + (log-rank test, P=0.0218) and survival free of @entity1 (log-rank test, P=0.0121) than in @entity8 -. When we restricted the analysis to @entity0 with both @entity2 and @entity7 (n=63) compared with those without (n=196), differences were even more pronounced. CONCLUSIONS: Prognosis for mortality, recurrent @entity1 , and overall functional outcome in @entity1 @entity0 with > or =1 silent @entity2 is more unfavorable than in @entity0 without such lesions. These findings sustain the idea of 2 @entity1 entities.

title: Two types of XXXX : further arguments from a study on prognosis.

answer: @entity4


abstract: The results of intraventricular (i.vt.) chemotherapy in 36 cases of adult @entity2 ( @entity2 ) were analyzed to define a useful and reliable form of central nervous system (CNS) prophylaxis. @entity0 received @entity3 ( @entity4 ) via an Ommaya reservoir six times every 4 weeks. This was repeated when bone marrow relapse occurred. Intraventricular maintenance CNS prophylaxis during half a year appeared adequate, since primary CNS relapses were seen in only two @entity0 (5.6%). These @entity0 had failed to follow the prophylaxis schedule. The procedure was implemented and repeated relatively easily and did not lead to @entity5 . The i.vt. route was also satisfactory for the treatment of initial and recurrent episodes of @entity1 ( @entity1 ). The therapy reduced morbidity caused by @entity1 to a minimum.

title: XXXX in adults: results of intraventricular maintenance chemotherapy for central nervous system prophylaxis and treatment.

answer: @entity2


abstract: Little it known about @entity0 stem cells although they are likely to be the earliest progenitors of @entity3 . Just as methylation can substitute for mutations to inactivate @entity1 suppressor genes, methylation can also substitute for mutations in a phylogenetic analysis. This review explains why stem cell dynamics may be important to @entity1 progression and how methylation patterns found in a normal @entity0 colon can be used to reconstruct the behavior of crypt stem cells. Histories are recorded in sequences and strategies used to reconstruct phylogenies from sequences likely apply to methylation patterns because both exhibit somatic inheritance. Such a quantitative analysis of colon methylation patterns infers stem cells live in niches containing multiple 'stem' cells. Although niche stem cell numbers remain constant, clonal succession is inherent to niches because periodically progeny from a single stem cell become dominant. These niche succession cycles may potentially accumulate multiple alterations because they resemble superficially the clonal succession of @entity1 progression except that they occur invisibly in the absence of selection or phenotypic change. Alterations without immediate selective value may hitchhike passively in the stem cells that become dominant during niche succession cycles. The inherent ability of a niche to @entity4 alterations (Muller's ratchet) is another potential mechanism besides instability and selection to sequentially accumulate multiple alterations. Many alterations found in @entity2 may reflect such occult clonal progression in normal colon.

title: Methylation reveals a niche: stem cell succession in XXXX colon crypts.

answer: @entity0


abstract: A syngeneic monoclonal antibody (MAb) (IC5F5) was successfully used in the immunotherapy of Rauscher-virus-induced @entity2 RMB-I cells. It is directed to a virus-encoded, but aberrantly processed protein, which is expressed on the cell membrane. When applied in vivo, it binds only to RMB-I @entity0 cells. BALB/c @entity1 were inoculated i.p. or i.v. with 10(7) RMB-I cells and died within 2-3 weeks due to increasing @entity0 load. @entity1 inoculated i.p. were completely cured by daily injections of ascites containing IC5F5. Disseminated @entity0 cells in liver and hemopoietic organs were observed after i.v. inoculation. Daily treatment with MAbs resulted in survival beyond 90 days. No antigenic modulation was observed when @entity0 tissue was analyzed 2-10 days after treatment. Treatment was successful even when therapy was postponed until day 5 following inoculation of @entity0 cells. When the number of ascites injections was reduced, survival was identical to that observed among repeatedly treated @entity1 . Ten- and 100-fold dilution of ascites fluid diminished the number of survivors, but still resulted in a median survival time of 38 and 20 days, respectively, as compared to 14 days for untreated @entity1 .

title: Use of syngeneic monoclonal antibodies in the therapy of disseminated XXXX cells.

answer: @entity2


abstract: The goal of the present study was to identify the factors related to the occurrence of @entity1 in deciduous teeth. Over a period of 25 months, 85 @entity0 between 10 months and 6 years of age were assisted by the staff of the Pediatric Dentistry Clinic of the Federal University of Santa Catarina (UFSC) Florian  polis, Brazil. The @entity0 , all assisted by only one professional, a dentist working as a trainee in the Pediatric Dentistry Clinic, had 157 traumatized teeth treated. The occurrence of @entity1 was higher in male @entity0 (51.8%) and in @entity0 between 1 and 3 years old. The average age was about =2.7 years. The 54.1% of the assisted @entity0 had more than one traumatized tooth and the repeat @entity1 occurred 16.7% of the time. @entity3 represented 98.7% of the cases and 76.4% of the @entity1 were on the maxillary central incisor teeth. Both sides of the mouth had approximately the same number of @entity1 . Luxations were more frequent (85.4%) than @entity2 (14.6%). Subluxations represented 38.8% of the luxated teeth. Falls were the main cause of @entity1 (78%). A percentage of 41.9 @entity0 were assisted by a dental professional during the first 24h after the incident. The study concluded that the deciduous dentition is mostly affected by luxations (subluxations) that occur specially on the maxillary central incisor teeth, in @entity0 between 1 and 3 years of age. Falls are the most common etiological factor and more than one traumatized tooth is common. Some of the cases were repeat @entity1 .

title: Traumatized primary teeth in XXXX assisted at the Federal University of Santa Catarina, Brazil.

answer: @entity0


abstract: OBJECTIVE: To confirm that performance in verbal learning and memory test (Rey's Auditory Verbal Learning Test-RAVLT) is a helpful early neuropsychological marker of @entity3 of @entity2 (DAT). METHODS: RAVLT was administered as part of a more extensive neuropsychological battery at baseline evaluation in 116 unselected @entity0 referred by @entity4 ( @entity4 ). @entity0 were followed longitudinally for 2 years (average interval of 27.7+/-4 months). Seventy @entity0 were included in the study: 27 developed probable DAT; 17 were diagnosed as cognitively normal @entity0 and 26 were diagnosed with @entity1 ( @entity1 ). Remaining @entity0 abandoned or they did not meet the criteria for DAT, @entity1 or control. Performance on RAVLT at the baseline evaluation was compared between groups. RESULTS: @entity0 diagnosed two years later with probable DAT showed lower results, more frequently performed a score of zero at the delayed recall test (Trial 6) and had a percentage of forgetting (difference between Trials 5 and 6) higher than 75%. Score at delayed recall test and percentage of forgetting correlated with functional scales such as MMSE, Geriatric Depression Screening, Informant Questionnaire and Blessed's @entity3 Rating. CONCLUSIONS: RAVLT could help to identify those @entity0 with @entity4 who would progress to DAT over a few years, and also to differentiate between the preclinical phase of @entity2 , mild @entity1 and normal aging. A score of zero at the delayed recall test or a percentage of forgetting > or =75% in @entity0 with @entity4 is suggestive of probable DAT in the future.

title: Rey verbal learning test is a useful tool for differential diagnosis in the preclinical phase of XXXX : comparison with mild @entity1 and normal aging.

answer: @entity2


abstract: OBJECTIVE: To confirm that performance in verbal learning and memory test (Rey's Auditory Verbal Learning Test-RAVLT) is a helpful early neuropsychological marker of @entity3 of @entity2 (DAT). METHODS: RAVLT was administered as part of a more extensive neuropsychological battery at baseline evaluation in 116 unselected @entity0 referred by @entity4 ( @entity4 ). @entity0 were followed longitudinally for 2 years (average interval of 27.7+/-4 months). Seventy @entity0 were included in the study: 27 developed probable DAT; 17 were diagnosed as cognitively normal @entity0 and 26 were diagnosed with @entity1 ( @entity1 ). Remaining @entity0 abandoned or they did not meet the criteria for DAT, @entity1 or control. Performance on RAVLT at the baseline evaluation was compared between groups. RESULTS: @entity0 diagnosed two years later with probable DAT showed lower results, more frequently performed a score of zero at the delayed recall test (Trial 6) and had a percentage of forgetting (difference between Trials 5 and 6) higher than 75%. Score at delayed recall test and percentage of forgetting correlated with functional scales such as MMSE, Geriatric Depression Screening, Informant Questionnaire and Blessed's @entity3 Rating. CONCLUSIONS: RAVLT could help to identify those @entity0 with @entity4 who would progress to DAT over a few years, and also to differentiate between the preclinical phase of @entity2 , mild @entity1 and normal aging. A score of zero at the delayed recall test or a percentage of forgetting > or =75% in @entity0 with @entity4 is suggestive of probable DAT in the future.

title: Rey verbal learning test is a useful tool for differential diagnosis in the preclinical phase of @entity2 : comparison with mild XXXX and normal aging.

answer: @entity1


abstract: The key decision in the treatment of @entity1 is the determination of the depth of the burn wound and the resultant decision on treatment options. The trend in the treatment of deep dermal and full thickness burns is toward very early excision and grafting to reduce the risk of @entity2 , decrease scar formation, shorten hospital stay, and thereby reducing costs. Traditionally, this has involved serial clinical examinations, which involves primarily subjective judgment. Various objective examination techniques, supplementing the clinical diagnosis, have been suggested, but none has yet achieved widespread clinical acceptance. It has frequently been postulated that the blood flow in injured tissue indicates the extent of tissue damage. In this study, the clinical and scientific impact of @entity3 (ICG) video angiography was tested in 20 @entity0 . A wide range of depth of injury and etiology was included and analyzed. In all cases considered, video angiography was possible. The measurements and observations correlated well with the @entity4 , which was assessed clinically (pre- and intraoperative assessment) and histologically (biopsies). In conclusion, ICG video angiography seems to be a practical method to describe vascular patency in a burn wound. The results indicate that ICG fluorescence angiography is a practical, accurate, and effective adjunct to clinical methods for estimating @entity1 and thereby to assist in the rational assessment of treatment options. Furthermore, it allows an objective, qualitative and quantitative observation of the dynamic changes in @entity1 , which are observed during the acute post-burn period, thereby indicating optimal timing of the first operation.

title: XXXX video angiographies help to identify burns requiring operation.

answer: @entity3


abstract: The aim of the study was to check whether dental @entity1 charts made in southern Finland can be used without modifications in other parts of the country. For this reason the dental @entity1 of 90 @entity0 living in the sparsely populated areas of Kuhmo in northeastern Finland was compared with that of a larger sample of Helsinki @entity0 . Most of the Kuhmo @entity0 were 7.0-8.5 and 10.5-12.5 yr of age. The method of Demirjian and associates was used to estimate dental @entity1 . The means of dental @entity1 scores were greater in Kuhmo in most half-year groups in both sexes. The median dental @entity1 scores of Kuhmo @entity0 were between the 50th and 84th percentile curves of Helsinki @entity0 . A referent of the same age and sex was chosen for each Kuhmo @entity0 from the Helsinki @entity0 . The paired t-test was based on the difference in dental age. The dental age of the Kuhmo @entity0 was higher (P less than 0.05). These findings suggest differences in dental @entity1 within a fairly homogeneous population, which should be considered when national charts are used.

title: Comparisons of dental XXXX between the rural community of Kuhmo in northeastern Finland and the city of Helsinki.

answer: @entity1


abstract: OBJECTIVE: One of the most important objectives in the management of @entity1 is to improve the quality of life of @entity0 . We summarized our experience in using Juniper's @entity1 quality of life questionnaire (AQLQ) in Chinese @entity2 . METHODS: Measurement instruments included self-administered AQLQ mandarin Chinese version and its standardized version. The data were from 210 AQLQ evaluations from 96 @entity0 . RESULTS: AQLQ and its four domains weakly correlated with forced expiratory volume in 1 second (FEV(1)) except the environment domain (r: 0.201 - 0.284). If the @entity2 @entity0 were graded into 4 groups based on FEV(1), AQLQ and its four domains significantly detected the differences among the groups. The change of AQLQ, however, was not correlated with the change of FEV(1). The change of AQLQ domain of symptoms was correlated with the change of peak expiratory flow. CONCLUSION: The Juniper's AQLQ performs well in Chinese @entity2 . AQLQ is correlated with pulmonary function and probably more sensitive and accurate than pulmonary function in the evaluation of disease severity.

title: [The use of Juniper's @entity1 quality of life questionnaire in Chinese XXXX ].

answer: @entity2


abstract: OBJECTIVE: One of the most important objectives in the management of @entity1 is to improve the quality of life of @entity0 . We summarized our experience in using Juniper's @entity1 quality of life questionnaire (AQLQ) in Chinese @entity2 . METHODS: Measurement instruments included self-administered AQLQ mandarin Chinese version and its standardized version. The data were from 210 AQLQ evaluations from 96 @entity0 . RESULTS: AQLQ and its four domains weakly correlated with forced expiratory volume in 1 second (FEV(1)) except the environment domain (r: 0.201 - 0.284). If the @entity2 @entity0 were graded into 4 groups based on FEV(1), AQLQ and its four domains significantly detected the differences among the groups. The change of AQLQ, however, was not correlated with the change of FEV(1). The change of AQLQ domain of symptoms was correlated with the change of peak expiratory flow. CONCLUSION: The Juniper's AQLQ performs well in Chinese @entity2 . AQLQ is correlated with pulmonary function and probably more sensitive and accurate than pulmonary function in the evaluation of disease severity.

title: [The use of Juniper's XXXX quality of life questionnaire in Chinese @entity2 ].

answer: @entity1


abstract: BACKGROUND AND OBJECTIVE: Our aim was to conduct a study to define the clinical and epidemiological characteristics of @entity0 with @entity2 typhus in Tenerife island (Canary islands, Spain). Moreover, we investigated the differential clinical features of this disease with regard to @entity6 . @entity0 AND METHOD: 5-year prospective study of @entity0 with @entity2 typhus (1998-2002) admited in a reference hospital in Tenerife, Spain. RESULTS: Thirty two @entity0 were included. @entity7 bite and @entity3 exposure were iuncommon (6.25%). The monthly distribution showed a peak of incidence in January, August and September, without a clear seasonal prevalence. Fever and @entity1 were the most common clinical features. @entity5 was present in 28% of the cases. Both an increase in liver enzyme levels (88%) and @entity4 (37.5%) were the most relevant laboratory findings. Organ complications were uncommon (18.75%). Antibiotics were administered to 90% of @entity0 and cure was achieved in all them. Compared with @entity6 , @entity0 with @entity2 typhus more commonly had @entity5 (p = 0.006) and @entity4 (p < 0.001). CONCLUSION: @entity2 typhus is an emerging rickettsiosis in Tenerife and must be considered in the differential diagnosis with @entity6 .

title: [ @entity2 typhus in Tenerife. Clinicoepidemiological study and differential clinical features with XXXX ].

answer: @entity6


abstract: BACKGROUND AND OBJECTIVE: Our aim was to conduct a study to define the clinical and epidemiological characteristics of @entity0 with @entity2 typhus in Tenerife island (Canary islands, Spain). Moreover, we investigated the differential clinical features of this disease with regard to @entity6 . @entity0 AND METHOD: 5-year prospective study of @entity0 with @entity2 typhus (1998-2002) admited in a reference hospital in Tenerife, Spain. RESULTS: Thirty two @entity0 were included. @entity7 bite and @entity3 exposure were iuncommon (6.25%). The monthly distribution showed a peak of incidence in January, August and September, without a clear seasonal prevalence. Fever and @entity1 were the most common clinical features. @entity5 was present in 28% of the cases. Both an increase in liver enzyme levels (88%) and @entity4 (37.5%) were the most relevant laboratory findings. Organ complications were uncommon (18.75%). Antibiotics were administered to 90% of @entity0 and cure was achieved in all them. Compared with @entity6 , @entity0 with @entity2 typhus more commonly had @entity5 (p = 0.006) and @entity4 (p < 0.001). CONCLUSION: @entity2 typhus is an emerging rickettsiosis in Tenerife and must be considered in the differential diagnosis with @entity6 .

title: [ XXXX typhus in Tenerife. Clinicoepidemiological study and differential clinical features with @entity6 ].

answer: @entity2


abstract: Disseminated @entity1 in a 71-year-old male represented the first clinical manifestation of a @entity5 . The dermal infiltrate in one of the nodules consisted predominantly of closely packed pleomorphic Langerhans' cells (LC) with typical Birbeck granules and a strong reactivity for @entity4 protein. The simultaneous presence of immature myeloid cells led to the suspicion of an underlying @entity6 . The diagnosis of @entity5 was subsequently confirmed by bone marrow histology and blood picture. Although some peritrabecular foci of histiocytic cells were detected in bone marrow, no LC could be identified by electron microscopy and histochemical methods. Tumorous aggregates of LC in @entity6 have not been described in the literature. @entity3 could be definitely excluded in the present case. This case obviously suggests an interrelation between the @entity2 and the focal accumulation of LC in the dermis. In animal studies by Katz et al. LC have been shown to originate in the bone marrow, whereas the origin of LC in @entity0 is still a matter of discussion. The present case supports the hypothesis that LC in @entity0 are also of myeloid origin. The neoplastic blood monocytes could be the precursors of the dermal LC. This differentiation did not take place in the bone marrow but only in the dermis where LC occur under nonneoplastic conditions ("homing").

title: @entity1 in XXXX .

answer: @entity5


abstract: Disseminated @entity1 in a 71-year-old male represented the first clinical manifestation of a @entity5 . The dermal infiltrate in one of the nodules consisted predominantly of closely packed pleomorphic Langerhans' cells (LC) with typical Birbeck granules and a strong reactivity for @entity4 protein. The simultaneous presence of immature myeloid cells led to the suspicion of an underlying @entity6 . The diagnosis of @entity5 was subsequently confirmed by bone marrow histology and blood picture. Although some peritrabecular foci of histiocytic cells were detected in bone marrow, no LC could be identified by electron microscopy and histochemical methods. Tumorous aggregates of LC in @entity6 have not been described in the literature. @entity3 could be definitely excluded in the present case. This case obviously suggests an interrelation between the @entity2 and the focal accumulation of LC in the dermis. In animal studies by Katz et al. LC have been shown to originate in the bone marrow, whereas the origin of LC in @entity0 is still a matter of discussion. The present case supports the hypothesis that LC in @entity0 are also of myeloid origin. The neoplastic blood monocytes could be the precursors of the dermal LC. This differentiation did not take place in the bone marrow but only in the dermis where LC occur under nonneoplastic conditions ("homing").

title: XXXX in @entity5 .

answer: @entity1


abstract: The present study was performed in order to evaluate the diagnostic usefulness of serial @entity2 and @entity5 measurements in @entity0 with severe burns. One of the main objective was to find out if these parameters are clinically relevant to determine the morbidity of a burn @entity0 and thereby the @entity0 's outcome. In 220 @entity0 with thermal injuries, @entity2 and @entity4 concentrations were measured daily. Blood samples were drawn immediately upon admission and thereafter daily until @entity0 's discharge or @entity3 . For both parameters, a characteristic course was noted: in the group of non-survivors, a decrease of @entity2 prior to @entity3 was noted, while survivors, increased prior to discharge. The time courses of both groups (survivors-non-survivors) differed statistically significantly (P=0.0068). An increase in @entity5 was observed in all non-survivors prior to @entity3 , but in the group of survivors @entity5 remained more or less unchanged. These time courses also had statistically significant differences (P=0.0004). In our 220 @entity0 , changes in @entity2 (P<0.0001, hazard ratio 1.02) and @entity5 (P=0.0008, hazard ratio 1.01) had comparable capability to predict the severity of a burn @entity1 and thereby its outcome than the established parameters in the treatment of burns (total body surface area burned, age, inhalation). We consider the serial measurements of @entity2 and @entity5 as clinically relevant to assess the morbidity of a @entity0 and thereby to estimate the @entity0 's outcome. We think that these serial measurements provide useful information for the clinician treating @entity0 with severe burns.

title: Serum @entity2 and XXXX : potential role in mortality prediction.

answer: @entity5


abstract: The present study was performed in order to evaluate the diagnostic usefulness of serial @entity2 and @entity5 measurements in @entity0 with severe burns. One of the main objective was to find out if these parameters are clinically relevant to determine the morbidity of a burn @entity0 and thereby the @entity0 's outcome. In 220 @entity0 with thermal injuries, @entity2 and @entity4 concentrations were measured daily. Blood samples were drawn immediately upon admission and thereafter daily until @entity0 's discharge or @entity3 . For both parameters, a characteristic course was noted: in the group of non-survivors, a decrease of @entity2 prior to @entity3 was noted, while survivors, increased prior to discharge. The time courses of both groups (survivors-non-survivors) differed statistically significantly (P=0.0068). An increase in @entity5 was observed in all non-survivors prior to @entity3 , but in the group of survivors @entity5 remained more or less unchanged. These time courses also had statistically significant differences (P=0.0004). In our 220 @entity0 , changes in @entity2 (P<0.0001, hazard ratio 1.02) and @entity5 (P=0.0008, hazard ratio 1.01) had comparable capability to predict the severity of a burn @entity1 and thereby its outcome than the established parameters in the treatment of burns (total body surface area burned, age, inhalation). We consider the serial measurements of @entity2 and @entity5 as clinically relevant to assess the morbidity of a @entity0 and thereby to estimate the @entity0 's outcome. We think that these serial measurements provide useful information for the clinician treating @entity0 with severe burns.

title: Serum XXXX and @entity5 : potential role in mortality prediction.

answer: @entity2


abstract: Burns caused by hot coolant from the reservoir of motorfarming tricycles have not been reported previously. We performed retrospective studies of such cases in 126 @entity0 with complete records in rural areas of China. The majority of victims were unmarried (59.5%), young (<40 years, >20, 55.6%), and male (male to female ratio 9:1). The burn accident occurred mostly during the busy seasons of spring and summer (66.7%). The mechanism of injury was usually the same. The drivers were trapped under the farming tricycle in a traffic accident and then hot coolant leaked from the mouth of the coolant, resulting in long contact with the hot fluid. The burn wounds were located mostly on the areas of the buttocks and lower extremities (especially on the thigh) (64.3%). The generally burned @entity0 had moderate burn areas, about 20-50% total burn surface area (TBSA) of deep partial @entity1 or @entity3 wound. For the purpose of decreasing the number of burns presenting, or at least making them less severe, the suggestions include: (1) the design of motorfarming tricycle should be changed; obviously separation of the coolant @entity2 from the seat is the most important factor in reducing such burns. (2) Road conditions should be improved to reduce traffic accidents and loading regulations introduced. (3) Traffic control should be enhanced, especially in rural areas.

title: Burn injuries associated with the water XXXX of motorfarming tricycles in China.

answer: @entity2


abstract: This study assesses the prognostic value of @entity2 recognized as a contractile response to inotropic stimulation in @entity0 with @entity6 in a large-scale prospective, multicenter, observational study. Four hundred twenty-five @entity0 (mean age 61 +/- 10 years) with angiographically proven @entity4 , previous (>3 months) @entity5 , and severe @entity6 (ejection fraction <35%; mean 28 +/- 6%) were enrolled in the study. Each @entity0 underwent low-dose @entity3 echocardiography (up to 10 microg/kg/min). Myocardial viability was identified as a rest-stress variation (Delta) in the wall motion score index (WMSI), in which each segment was scored from 1 = normal to 4 = dyskinetic in a 16-segment model of the left ventricle. Myocardial viability was identified as an improvement of >/=0.40 in WMSI. All @entity0 were followed for a median of 3.1 years. One hundred eighty-eight were revascularized either by coronary artery bypass grafting (n = 118) or coronary angioplasty (n = 70). The only end point analyzed was @entity1 . In the revascularized group, @entity1 occurred in 4 of the 52 @entity0 with and in 37 of the 136 @entity0 without @entity2 (7.7% vs 27.2%, p <0.003). Kaplan-Meier survival estimates showed a better outcome for those @entity0 with compared to @entity0 without @entity2 who underwent coronary revascularization (90.1% vs 62%, p <0.0078). Thus, in severe @entity6 , @entity2 by low-dose @entity3 echocardiography is associated with improved survival in revascularized @entity0 .

title: Prognostic value of XXXX recognized by low-dose @entity3 echocardiography in chronic @entity6 .

answer: @entity2


abstract: This study assesses the prognostic value of @entity2 recognized as a contractile response to inotropic stimulation in @entity0 with @entity6 in a large-scale prospective, multicenter, observational study. Four hundred twenty-five @entity0 (mean age 61 +/- 10 years) with angiographically proven @entity4 , previous (>3 months) @entity5 , and severe @entity6 (ejection fraction <35%; mean 28 +/- 6%) were enrolled in the study. Each @entity0 underwent low-dose @entity3 echocardiography (up to 10 microg/kg/min). Myocardial viability was identified as a rest-stress variation (Delta) in the wall motion score index (WMSI), in which each segment was scored from 1 = normal to 4 = dyskinetic in a 16-segment model of the left ventricle. Myocardial viability was identified as an improvement of >/=0.40 in WMSI. All @entity0 were followed for a median of 3.1 years. One hundred eighty-eight were revascularized either by coronary artery bypass grafting (n = 118) or coronary angioplasty (n = 70). The only end point analyzed was @entity1 . In the revascularized group, @entity1 occurred in 4 of the 52 @entity0 with and in 37 of the 136 @entity0 without @entity2 (7.7% vs 27.2%, p <0.003). Kaplan-Meier survival estimates showed a better outcome for those @entity0 with compared to @entity0 without @entity2 who underwent coronary revascularization (90.1% vs 62%, p <0.0078). Thus, in severe @entity6 , @entity2 by low-dose @entity3 echocardiography is associated with improved survival in revascularized @entity0 .

title: Prognostic value of @entity2 recognized by low-dose @entity3 echocardiography in chronic XXXX .

answer: @entity6


abstract: This study assesses the prognostic value of @entity2 recognized as a contractile response to inotropic stimulation in @entity0 with @entity6 in a large-scale prospective, multicenter, observational study. Four hundred twenty-five @entity0 (mean age 61 +/- 10 years) with angiographically proven @entity4 , previous (>3 months) @entity5 , and severe @entity6 (ejection fraction <35%; mean 28 +/- 6%) were enrolled in the study. Each @entity0 underwent low-dose @entity3 echocardiography (up to 10 microg/kg/min). Myocardial viability was identified as a rest-stress variation (Delta) in the wall motion score index (WMSI), in which each segment was scored from 1 = normal to 4 = dyskinetic in a 16-segment model of the left ventricle. Myocardial viability was identified as an improvement of >/=0.40 in WMSI. All @entity0 were followed for a median of 3.1 years. One hundred eighty-eight were revascularized either by coronary artery bypass grafting (n = 118) or coronary angioplasty (n = 70). The only end point analyzed was @entity1 . In the revascularized group, @entity1 occurred in 4 of the 52 @entity0 with and in 37 of the 136 @entity0 without @entity2 (7.7% vs 27.2%, p <0.003). Kaplan-Meier survival estimates showed a better outcome for those @entity0 with compared to @entity0 without @entity2 who underwent coronary revascularization (90.1% vs 62%, p <0.0078). Thus, in severe @entity6 , @entity2 by low-dose @entity3 echocardiography is associated with improved survival in revascularized @entity0 .

title: Prognostic value of @entity2 recognized by low-dose XXXX echocardiography in chronic @entity6 .

answer: @entity3


abstract: BACKGROUND: @entity1 free radicals have been implicated as mediators of @entity8 in @entity0 of @entity2 ( @entity2 ). This study was designed to elucidate plasma oxidant/antioxidant status in @entity2 , with the aim of evaluating the importance of antioxidant therapy in the management of this disease. METHODS: The study included 40 @entity0 of @entity2 who were randomly divided into two subgroups of 20 each. One group received conventional treatment for 12 weeks and in the other group conventional treatment was supplemented with antioxidants for the same duration. Twenty age- and sex-matched normal individuals constituted the control group. Blood samples of controls and @entity0 were collected at the time of presentation and analyzed for total @entity5 , @entity7 , @entity3 and @entity4 ( @entity6 -marker of oxidative stress). The investigations were repeated in the @entity0 after 12 weeks. RESULTS: The blood concentrations of total @entity5 , @entity7 and @entity3 were found to be significantly lower in @entity2 @entity0 as compared to healthy controls, while the concentrations of @entity6 were much higher. There was a statistically significant increase in the posttreatment concentrations of these antioxidants, along with a decrease in the concentrations of @entity6 . CONCLUSIONS: The antioxidant defense system is compromised in @entity2 @entity0 . There is a shift in the oxidant/antioxidant balance in favor of lipid peroxidation, which could lead to the @entity8 observed in the disease. The results suggest the necessity for therapeutic co-administration of antioxidants along with conventional drugs to such @entity0 . However, due to the limited number of cases included in this study, more studies may be required to substantiate the results and arrive at a definite conclusion, in terms of safety and efficacy of adding on antioxidant therapy for the treatment of @entity2 .

title: Antioxidant status in XXXX and role of antioxidant therapy.

answer: @entity2


abstract: An attempt has been made to determine if the structural renewal of bone tissue takes place to a greater extent in the spongiosa than in the compacta and how this is related to the more extensive free surface area in the former. To this purpose, on transverse sections of the femur and 2 degrees lumbar vertebral body of the female lactating @entity0 fed a normal (L group) or a @entity2 free diet (H group) the area of compact and spongy bone, and the perimeter of the trabeculae were measured. Then TBV, MTPT, MTPD, MTPS, Sv and S/V, according to the Parfitt et al. (1983) method were calculated. In the femurs of @entity0 maintained on a normal @entity2 diet @entity3 takes place to a higher degree in the spongiosa than in the compacta. In the distal metaphysis, moreover, the @entity3 is more elevated than in other femoral regions. In the second lumbar vertebral body the bone rarefaction appears to have a similar extent in the compacta and spongiosa and in the three levels inspected. In @entity0 maintained on a restricted @entity2 intake the @entity1 is enhanced but the bone is removed predominantly from the compacta in all the femoral regions except in the distal metaphysis and, to a similar degree, from the compacta and the spongiosa of the vertebral body. In the centrodiaphyseal compacta the bone is reabsorbed exclusively at the endosteal level, while in the spongiosa the frameworks subjected to a more extensive resorption occupy a topographic position specific for each single region, and are often formed of thin trabeculae. The dynamic of the trabecular resorption seems to be different in the various spongy frameworks: in each of these it would take place by the removal of the entire trabecula or the thinning of the single trabeculae or by both mechanisms. Lastly, significative correlation was found between trabecular @entity3 and trabecular thickness, none with trabecular surfaces. This study shows that bone removal is not regulated by the extent of the trabecular free surface. The mechanisms involved in the control of the distribution of bone removal are strictly connected with those controlling the trabecular thickness. They are probably of a mechanical nature.

title: Distribution of resorption processes in the compacta and spongiosa of bones from lactating @entity0 fed a low- XXXX diet.

answer: @entity2


abstract: An attempt has been made to determine if the structural renewal of bone tissue takes place to a greater extent in the spongiosa than in the compacta and how this is related to the more extensive free surface area in the former. To this purpose, on transverse sections of the femur and 2 degrees lumbar vertebral body of the female lactating @entity0 fed a normal (L group) or a @entity2 free diet (H group) the area of compact and spongy bone, and the perimeter of the trabeculae were measured. Then TBV, MTPT, MTPD, MTPS, Sv and S/V, according to the Parfitt et al. (1983) method were calculated. In the femurs of @entity0 maintained on a normal @entity2 diet @entity3 takes place to a higher degree in the spongiosa than in the compacta. In the distal metaphysis, moreover, the @entity3 is more elevated than in other femoral regions. In the second lumbar vertebral body the bone rarefaction appears to have a similar extent in the compacta and spongiosa and in the three levels inspected. In @entity0 maintained on a restricted @entity2 intake the @entity1 is enhanced but the bone is removed predominantly from the compacta in all the femoral regions except in the distal metaphysis and, to a similar degree, from the compacta and the spongiosa of the vertebral body. In the centrodiaphyseal compacta the bone is reabsorbed exclusively at the endosteal level, while in the spongiosa the frameworks subjected to a more extensive resorption occupy a topographic position specific for each single region, and are often formed of thin trabeculae. The dynamic of the trabecular resorption seems to be different in the various spongy frameworks: in each of these it would take place by the removal of the entire trabecula or the thinning of the single trabeculae or by both mechanisms. Lastly, significative correlation was found between trabecular @entity3 and trabecular thickness, none with trabecular surfaces. This study shows that bone removal is not regulated by the extent of the trabecular free surface. The mechanisms involved in the control of the distribution of bone removal are strictly connected with those controlling the trabecular thickness. They are probably of a mechanical nature.

title: Distribution of resorption processes in the compacta and spongiosa of bones from lactating XXXX fed a low- @entity2 diet.

answer: @entity0


abstract: 33 subjects with evidence of active @entity3 were treated by modified Widman flap surgery and systemic @entity1 (1 g/day for 21 days). @entity0 samples were taken from 41 sites in 12 of these subjects before and 6 months after therapy for predominant cultivable microbiota studies. Mean pocket depth and attachment levels in the 41 sampled sites were 7.1 +/- 2.9 mm and 7.7 +/- 3.2 mm prior to therapy and 4.8 +/- 2.3 mm and 6.2 +/- 3.4 mm after therapy. @entity10 and @entity11 were more frequently detected in samples taken after therapy, while @entity5 , S. morbillorum, @entity9 and W. recta were less frequently detected after therapy. A. actinomycetemcomitans were detected in 7 sites pretherapy and 1 site post therapy. The frequency of detection of @entity4 and @entity6 was virtually unchanged. The mean levels of the Actinomyces sp., A. actinomycetemcomitans, @entity4 , @entity6 , S. morbillorum, @entity9 and W. recta were decreased after therapy, while the mean levels of @entity10 , @entity7 , @entity2 II and @entity11 were increased after therapy. @entity11 showed the greatest increase to 8.2% of the microbiota. In the second phase of the study, @entity0 samples from 94 sites in the 33 treated subjects were analyzed by predominant cultivable techniques. As a result of therapy, 24 sites exhibited @entity8 greater than 2 mm, 23 sites exhibited "gain" greater than 2 mm and the remaining 47 sites were considered to be unchanging.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effect of modified Widman flap surgery and systemic XXXX on the subgingival microbiota of periodontal lesions.

answer: @entity1


abstract: @entity10 ) inhibits @entity8 (interleukin (IL)-1beta-converting enzyme) and @entity9 , thereby regulating production of the pro-inflammatory cytokine @entity4 and susceptibility to @entity9 -induced apoptosis. We show that cellular @entity10 mRNA and protein are induced by @entity4 , lipopolysaccharide, and @entity2 . We identified functional imperfect nuclear factor-kappaB (NF-kappaB) sites at -135 and -88 and a consensus @entity3 ( @entity3 ) site at -308 in the @entity10 promoter region. Using transient transfections in HepG2 cells to assay @entity10 promoter mutations, we find that mutational ablation of the @entity3 site or of either NF-kappaB site reduces @entity4 -induced expression of @entity10 by approximately 60%. Mutational ablation of the two NF-kappaB sites and of the @entity3 site nearly abolishes both basal and @entity4 -induced expression of @entity10 . Nuclear extracts from @entity4 -treated HepG2 cells exhibited strong, @entity4 -inducible binding to the NF-kappaB sites and to the @entity3 site. Electrophoretic mobility shift assays show that after @entity4 treatment @entity3 / @entity5 and @entity11 bind to the @entity3 site, whereas the @entity6 / @entity7 heterodimer binds to the two NF-kappaB sites. @entity1 induce @entity10 , but induction of @entity10 by @entity1 and @entity4 is not synergistic. In transiently transfected, @entity1 receptor-positive HepG2ER7 cells, @entity1 do not interfere with @entity4 induction, whereas @entity4 exhibits dose-dependent repression of @entity1 -inducible @entity10 expression. Our surprising finding that the pro-inflammatory cytokine @entity4 strongly induces @entity10 suggests a novel mechanism for regulating @entity0 and apoptosis through a negative feedback loop controlling expression of the anti-inflammatory and anti-apoptotic protein, @entity10 .

title: Modulators of @entity0 use nuclear factor-kappa B and @entity3 sites to induce the @entity8 and XXXX inhibitor, proteinase inhibitor 9.

answer: @entity9


abstract: @entity10 ) inhibits @entity8 (interleukin (IL)-1beta-converting enzyme) and @entity9 , thereby regulating production of the pro-inflammatory cytokine @entity4 and susceptibility to @entity9 -induced apoptosis. We show that cellular @entity10 mRNA and protein are induced by @entity4 , lipopolysaccharide, and @entity2 . We identified functional imperfect nuclear factor-kappaB (NF-kappaB) sites at -135 and -88 and a consensus @entity3 ( @entity3 ) site at -308 in the @entity10 promoter region. Using transient transfections in HepG2 cells to assay @entity10 promoter mutations, we find that mutational ablation of the @entity3 site or of either NF-kappaB site reduces @entity4 -induced expression of @entity10 by approximately 60%. Mutational ablation of the two NF-kappaB sites and of the @entity3 site nearly abolishes both basal and @entity4 -induced expression of @entity10 . Nuclear extracts from @entity4 -treated HepG2 cells exhibited strong, @entity4 -inducible binding to the NF-kappaB sites and to the @entity3 site. Electrophoretic mobility shift assays show that after @entity4 treatment @entity3 / @entity5 and @entity11 bind to the @entity3 site, whereas the @entity6 / @entity7 heterodimer binds to the two NF-kappaB sites. @entity1 induce @entity10 , but induction of @entity10 by @entity1 and @entity4 is not synergistic. In transiently transfected, @entity1 receptor-positive HepG2ER7 cells, @entity1 do not interfere with @entity4 induction, whereas @entity4 exhibits dose-dependent repression of @entity1 -inducible @entity10 expression. Our surprising finding that the pro-inflammatory cytokine @entity4 strongly induces @entity10 suggests a novel mechanism for regulating @entity0 and apoptosis through a negative feedback loop controlling expression of the anti-inflammatory and anti-apoptotic protein, @entity10 .

title: Modulators of @entity0 use nuclear factor-kappa B and XXXX sites to induce the @entity8 and @entity9 inhibitor, proteinase inhibitor 9.

answer: @entity3


abstract: @entity10 ) inhibits @entity8 (interleukin (IL)-1beta-converting enzyme) and @entity9 , thereby regulating production of the pro-inflammatory cytokine @entity4 and susceptibility to @entity9 -induced apoptosis. We show that cellular @entity10 mRNA and protein are induced by @entity4 , lipopolysaccharide, and @entity2 . We identified functional imperfect nuclear factor-kappaB (NF-kappaB) sites at -135 and -88 and a consensus @entity3 ( @entity3 ) site at -308 in the @entity10 promoter region. Using transient transfections in HepG2 cells to assay @entity10 promoter mutations, we find that mutational ablation of the @entity3 site or of either NF-kappaB site reduces @entity4 -induced expression of @entity10 by approximately 60%. Mutational ablation of the two NF-kappaB sites and of the @entity3 site nearly abolishes both basal and @entity4 -induced expression of @entity10 . Nuclear extracts from @entity4 -treated HepG2 cells exhibited strong, @entity4 -inducible binding to the NF-kappaB sites and to the @entity3 site. Electrophoretic mobility shift assays show that after @entity4 treatment @entity3 / @entity5 and @entity11 bind to the @entity3 site, whereas the @entity6 / @entity7 heterodimer binds to the two NF-kappaB sites. @entity1 induce @entity10 , but induction of @entity10 by @entity1 and @entity4 is not synergistic. In transiently transfected, @entity1 receptor-positive HepG2ER7 cells, @entity1 do not interfere with @entity4 induction, whereas @entity4 exhibits dose-dependent repression of @entity1 -inducible @entity10 expression. Our surprising finding that the pro-inflammatory cytokine @entity4 strongly induces @entity10 suggests a novel mechanism for regulating @entity0 and apoptosis through a negative feedback loop controlling expression of the anti-inflammatory and anti-apoptotic protein, @entity10 .

title: Modulators of XXXX use nuclear factor-kappa B and @entity3 sites to induce the @entity8 and @entity9 inhibitor, proteinase inhibitor 9.

answer: @entity0


abstract: @entity10 ) inhibits @entity8 (interleukin (IL)-1beta-converting enzyme) and @entity9 , thereby regulating production of the pro-inflammatory cytokine @entity4 and susceptibility to @entity9 -induced apoptosis. We show that cellular @entity10 mRNA and protein are induced by @entity4 , lipopolysaccharide, and @entity2 . We identified functional imperfect nuclear factor-kappaB (NF-kappaB) sites at -135 and -88 and a consensus @entity3 ( @entity3 ) site at -308 in the @entity10 promoter region. Using transient transfections in HepG2 cells to assay @entity10 promoter mutations, we find that mutational ablation of the @entity3 site or of either NF-kappaB site reduces @entity4 -induced expression of @entity10 by approximately 60%. Mutational ablation of the two NF-kappaB sites and of the @entity3 site nearly abolishes both basal and @entity4 -induced expression of @entity10 . Nuclear extracts from @entity4 -treated HepG2 cells exhibited strong, @entity4 -inducible binding to the NF-kappaB sites and to the @entity3 site. Electrophoretic mobility shift assays show that after @entity4 treatment @entity3 / @entity5 and @entity11 bind to the @entity3 site, whereas the @entity6 / @entity7 heterodimer binds to the two NF-kappaB sites. @entity1 induce @entity10 , but induction of @entity10 by @entity1 and @entity4 is not synergistic. In transiently transfected, @entity1 receptor-positive HepG2ER7 cells, @entity1 do not interfere with @entity4 induction, whereas @entity4 exhibits dose-dependent repression of @entity1 -inducible @entity10 expression. Our surprising finding that the pro-inflammatory cytokine @entity4 strongly induces @entity10 suggests a novel mechanism for regulating @entity0 and apoptosis through a negative feedback loop controlling expression of the anti-inflammatory and anti-apoptotic protein, @entity10 .

title: Modulators of @entity0 use nuclear factor-kappa B and @entity3 sites to induce the XXXX and @entity9 inhibitor, proteinase inhibitor 9.

answer: @entity8


abstract: BACKGROUND: @entity1 ( @entity1 ) in older adults is often associated with preserved left ventricular systolic function (LVSF). The objective of this retrospective follow-up study was to determine the correlates and outcomes of preserved LVSF among older adults hospitalized with @entity1 . METHODS: We studied older Medicare beneficiaries hospitalized with @entity1 (n = 1091) who had documented LVSF evaluation (n = 438). LVSF was defined as preserved if left ventricular ejection fraction was > or =40%. The Fisher exact test and the Student t test were used to compare baseline characteristics between @entity0 with preserved versus those with impaired LVSF. Multivariate logistic regression analysis was used to determine the correlates of preserved LVSF. Cox proportional hazards analyses were used to determine the associations between LVSF and both 4-year mortality rates and 6-month readmission rates and the associations between @entity2 ( @entity2 ) inhibitor use and 4-year mortality rates, separately, in @entity0 with preserved and impaired LVSF. RESULTS: Of the 438 @entity0 , 200 (46%) had preserved LVSF. @entity0 were more likely to have preserved LVSF (odds ratio [OR] = 2.44, 95% CI 1.57-3.81) than @entity0 . Preserved LVSF was associated with lower 4-year mortality rates (adjusted hazards ratio [HR] = 0.67, 95% CI 0.52-0.86) but not with 6-month readmission rates (adjusted HR = 0.66, 95% CI 0.41-1.09). The use of @entity2 inhibitors was associated with lower 4-year mortality rates in @entity0 with impaired LVSF (adjusted HR = 0.61, 95% CI 0.43-0.86) but not in those with preserved LVSF (HR = 0.96, 95% CI 0.65-1.42). CONCLUSIONS: Among older adults hospitalized with @entity1 , preserved LVSF was common among @entity0 and was associated with significantly higher morbidity and mortality rates, which were unaffected by treatment with @entity2 inhibitors.

title: Correlates and outcomes of preserved left ventricular systolic function among older adults hospitalized with XXXX .

answer: @entity1


abstract: The accuracy of historical information derived from self-administered questionnaires must be confirmed. We report the results of studies conducted to assess the reliability and validity of data collected from a comprehensive @entity1 risk factor questionnaire developed at The University of Texas M.D. Anderson @entity1 Center. A comparison of the basic demographic data of a randomly selected sample of 80 respondents and 70 nonrespondents revealed no fundamental ethnic or socioeconomic differences. We verified self-reported past illnesses, surgical procedures, and @entity1 by reviewing 72 @entity0 charts, using stringent diagnostic criteria for verification. We noted substantial agreement between self-reported and documented illnesses and operations. With the exception of nine @entity0 who misclassified metastatic disease, the verification of primary @entity1 was excellent. We determined reliability by interviewing 50 of these @entity0 by telephone. Questions with a dichotomous outcome (e.g., smoking status) were reliably answered; however, those requiring quantification (e.g., amount of @entity2 consumed) were less accurately reported on interview. While we recognize the limitations of self-administered questionnaires, we believe this program will develop into a comprehensive, standardized, easily accessible @entity0 risk factor data base.

title: The development of a comprehensive, institution-based XXXX risk evaluation program: II. Validity and reliability of questionnaire data.

answer: @entity0


abstract: BACKGROUND: Recombinant FVIIa (rFVIIa/NovoSeven) is a novel hemostatic agent originally developed to treat @entity0 with @entity3 who had developed inhibitors. Several case reports have suggested that rFVIIa may be effective in treating @entity0 without a pre-existing @entity8 who have uncontrolled @entity4 . STUDY DESIGN AND METHODS: Data on the efficacy and safety of rFVIIa in the treatment of @entity4 were obtained retrospectively from the NovoSeven extended-use data collection system. RESULTS: A total of 40 @entity0 received rFVIIa for uncontrolled @entity4 , and in these @entity0 , @entity4 stopped or decreased in 32 (80%). Blood product usage was significantly decreased after rFVIIa administration. @entity7 events occurred in three @entity0 with additional risk factors for @entity5 . Of 40 @entity0 , 23 (57.5%) died. Bleeding was the direct cause of @entity1 in seven cases (all within 24 hr of administration of rFVIIa). The remaining 16 deaths were the result of @entity2 , @entity6 , or the underlying disease. CONCLUSIONS: In this retrospective study of data voluntarily submitted to a web-based drug surveillance program, we present preliminary results on the use of rFVIIa in nonhemophilia @entity0 with @entity4 . Although some efficacy is suggested, there was a high mortality rate from nonhemorrhagic causes. Randomized controlled trials are needed to properly assess the role of rFVIIa in the management of @entity4 .

title: Recombinant FVIIa in the management of uncontrolled XXXX .

answer: @entity4


abstract: BACKGROUND: Posterior horseshoe @entity2 with deep postanal space abscess is a complex disease. Most @entity0 have a history of @entity4 or surgery for @entity2 -in-ano. METHODS: Twenty-five @entity0 who underwent surgery for posterior horseshoe @entity2 with deep postanal space abscess were analyzed retrospectively with respect to age, gender, previous surgery for @entity2 -in-ano, number of external openings, diagnostic studies, concordance between preoperative studies and operative findings for the extent of disease, operating time, healing time, complications, and recurrence. RESULTS: There were 22 (88%) @entity0 and 3 (12%) @entity0 with a median age of 37 (range, 25-58) years. The median duration of disease was 13 (range, 3-96) months. There was one external opening in 12 (48%) @entity0 , 2 in 8 (32%), 3 in 4 (16%), and 4 in 1 (4%). Preoperative diagnosis of horseshoe @entity2 was made by contrast fistulography in 4 (16%) @entity0 , by ultrasound in 3 (12%), by magnetic resonance imaging in 6 (24%), and by physical examination only in the remainder (48%). The mean +/- SD operating time was 47 +/- 10 min. The mean +/- SD healing time was 12 +/- 3 weeks. Three of the 25 @entity0 (12%) had @entity1 . Nineteen (76%) @entity0 had undergone previous surgery for @entity2 -in-ano, while five (20%) had only perianal abscess drainage. Neither morbidity nor mortality developed. All @entity0 were followed up for a median of 35 (range, 6-78) months and no recurrence was observed. CONCLUSIONS: Fistulotomy of the tracts along the arms of horseshoe @entity2 and drainage of the deep postanal space abscess with posterior midline incision that severs both the lower edge of the internal sphincter and the subcutaneous external sphincter and divides the superficial external sphincter into halves gives excellent results with no recurrence. When it is necessary, severing the halves of the superficial external sphincter unilaterally or even bilaterally in the same session does not result in anal @entity3 . Close follow-up of @entity0 until the wounds completely healed is essential in the prevention of premature wound closure and recurrence.

title: Fistulotomy and drainage of deep postanal space abscess in the treatment of posterior horseshoe XXXX .

answer: @entity2


abstract: Marked non-communicating @entity6 may rarely cause @entity14 producing either a dilated cystic cavity (ventricular diverticulum) or communication between ventricle system and subarachnoid space (spontaneous ventriculostomy). @entity3 has been believed to be collection of cerebrospinal fluid which escaped beneath the pia mater after rupture of @entity7 . We proposed herein to report a case of @entity3 which accompanied with @entity10 of the lateral ventricle. A nine year-old @entity0 admitted to our hospital complaining of clumsiness of hands and walking, disability of reading, @entity2 and @entity4 . The neurological examination revealed @entity11 , @entity9 , @entity12 , @entity8 , @entity5 of @entity13 . CT brain scan showed a large high density area at the trigone of the left lateral ventricle with non-communicating @entity6 and an extra-axial low density area in the posterior fossa. The medial space of the left trigone was especially ballooned and is just shifted above incisura tentoria by the @entity1 . The intraventricular @entity1 was totally removed by operation and proved to be benign @entity10 microscopically. The subtentorial mass was confirmed to be a cyst contiguous to the medial trigone of the lateral ventricle, namely ventricular diverticulum. Three special features were recognized in this case. The first, this was the first example of @entity14 accompanied with @entity1 in the lateral ventricle reviewing all reports of both ventricular diverticulum and spontaneous ventriculostomy. The second, this ventricular diverticulum was not produced merely by @entity6 alone but mainly by direct effects of the @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of XXXX accompanied with @entity10 in the lateral ventricle].

answer: @entity3


abstract: Marked non-communicating @entity6 may rarely cause @entity14 producing either a dilated cystic cavity (ventricular diverticulum) or communication between ventricle system and subarachnoid space (spontaneous ventriculostomy). @entity3 has been believed to be collection of cerebrospinal fluid which escaped beneath the pia mater after rupture of @entity7 . We proposed herein to report a case of @entity3 which accompanied with @entity10 of the lateral ventricle. A nine year-old @entity0 admitted to our hospital complaining of clumsiness of hands and walking, disability of reading, @entity2 and @entity4 . The neurological examination revealed @entity11 , @entity9 , @entity12 , @entity8 , @entity5 of @entity13 . CT brain scan showed a large high density area at the trigone of the left lateral ventricle with non-communicating @entity6 and an extra-axial low density area in the posterior fossa. The medial space of the left trigone was especially ballooned and is just shifted above incisura tentoria by the @entity1 . The intraventricular @entity1 was totally removed by operation and proved to be benign @entity10 microscopically. The subtentorial mass was confirmed to be a cyst contiguous to the medial trigone of the lateral ventricle, namely ventricular diverticulum. Three special features were recognized in this case. The first, this was the first example of @entity14 accompanied with @entity1 in the lateral ventricle reviewing all reports of both ventricular diverticulum and spontaneous ventriculostomy. The second, this ventricular diverticulum was not produced merely by @entity6 alone but mainly by direct effects of the @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of @entity3 accompanied with XXXX in the lateral ventricle].

answer: @entity10


abstract: We performed the longitudinal study in @entity0 with focal spikes about characteristic changes in @entity1 foci for periods of between one year and 5 years 9 months. The 116 @entity1 @entity0 were evaluated, ranging in onset age from 10 month to 12 year 9 month old (mean age: 6 year 11 month). They were subdivided into four groups according to their region of foci: group 1, 41 @entity0 with the centro-temporal spikes ( @entity2 ); group 2, 14 @entity0 with the occipital spikes; group 3, 6 @entity0 with frontal pole spikes; group 4, 55 @entity0 with the other focal spikes. EEG examinations were followed 6 months interval in each @entity0 , and total 412 EEG trancing were investigated. Migration of @entity1 foci was recognized in thirty eight @entity0 (32.8%): 17 (41%) in @entity2 , 7 (50%) in occipital spikes, 4 (67%) in frontal pole spikes and 10 (18%) in other spikes. The mean time to the migration of next foci was 45.6 months in @entity2 , 18.4 months in occipital spikes, 17.6 months in frontal pole spike and 61.4 months in other spikes. As to the regions of migrated foci, @entity2 tended to move to the near and horizontal areas such as from central to temporal. Whereas, occipital spikes and frontal pole spikes tended to move to the distant and vertical areas such as from occipital to frontal pole and from frontal pole to occipital. But other spikes showed no tendency.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Longitudinal study of XXXX foci in childhood].

answer: @entity1


abstract: The cerebral blood flow velocities (CBFV) of @entity0 with perinatal @entity4 and @entity5 ( @entity5 ) in the first 12 hours of their lives have been the chief focus of our concern in this study. @entity5 which can develop in the earlier hours of @entity5 , and the detection and diagnosis of this condition with color Doppler ultrasonography (cD-USG) will be put into discussion. Twenty-three full-term newborn @entity0 who had perinatal @entity4 and @entity5 together with a control group constituting twenty full-term newborn @entity0 who produced no problems, were included in our study. All of the @entity0 underwent cD-USG in the postpartum period of the first 12 hours (mean 8.4 hours). Measurements being based upon peak systolic velocity (PSV), end diastolic velocity (EDV) and Pouecelout's resistive index (RI) in anterior and middle cerebral arteries were conducted. The @entity0 , having been discharged from the unit they were followed up for mean 9.8 months in the outpatient clinic. PSV and EDV counts in the postpartum first 12 hours of 23 @entity0 who were detected to have @entity5 were found to be significantly lower compared to the control group, whereas RI counts were found to be significantly higher (p < 0.05). The counts obtained from the right and left cerebral arteries of the @entity0 with @entity5 were found to be corraleted with each others. The neonates in the @entity0 group were observed to have gone through this prognosis: Three of them died, three of them had @entity1 , one of them had @entity2 , and three of them had @entity3 . When we compared the CBFV of the 10 neonates who had poor prognosis, retrospectively with the other 13 neonates who had good prognosis, PSV and EDV were found to be significantly lower and RI significantly higher (p < 0.05). In the light of the data we have obtained, cD-USG can be considered to be a highly practical device in evaluating CBVF of the @entity0 with @entity5 . A skillful detection of the decrease in cerebral blood flow which can develop in the postasphyxial first 12 hours and the prospective treatments being based upon this approach would contribute to the diagnosis, treatment and prognosis of such cases.

title: Clinical value of color Doppler ultrasonography measurements of full-term newborns with perinatal XXXX and @entity5 in the first 12 hours of life and long-term prognosis.

answer: @entity4


abstract: The cerebral blood flow velocities (CBFV) of @entity0 with perinatal @entity4 and @entity5 ( @entity5 ) in the first 12 hours of their lives have been the chief focus of our concern in this study. @entity5 which can develop in the earlier hours of @entity5 , and the detection and diagnosis of this condition with color Doppler ultrasonography (cD-USG) will be put into discussion. Twenty-three full-term newborn @entity0 who had perinatal @entity4 and @entity5 together with a control group constituting twenty full-term newborn @entity0 who produced no problems, were included in our study. All of the @entity0 underwent cD-USG in the postpartum period of the first 12 hours (mean 8.4 hours). Measurements being based upon peak systolic velocity (PSV), end diastolic velocity (EDV) and Pouecelout's resistive index (RI) in anterior and middle cerebral arteries were conducted. The @entity0 , having been discharged from the unit they were followed up for mean 9.8 months in the outpatient clinic. PSV and EDV counts in the postpartum first 12 hours of 23 @entity0 who were detected to have @entity5 were found to be significantly lower compared to the control group, whereas RI counts were found to be significantly higher (p < 0.05). The counts obtained from the right and left cerebral arteries of the @entity0 with @entity5 were found to be corraleted with each others. The neonates in the @entity0 group were observed to have gone through this prognosis: Three of them died, three of them had @entity1 , one of them had @entity2 , and three of them had @entity3 . When we compared the CBFV of the 10 neonates who had poor prognosis, retrospectively with the other 13 neonates who had good prognosis, PSV and EDV were found to be significantly lower and RI significantly higher (p < 0.05). In the light of the data we have obtained, cD-USG can be considered to be a highly practical device in evaluating CBVF of the @entity0 with @entity5 . A skillful detection of the decrease in cerebral blood flow which can develop in the postasphyxial first 12 hours and the prospective treatments being based upon this approach would contribute to the diagnosis, treatment and prognosis of such cases.

title: Clinical value of color Doppler ultrasonography measurements of full-term newborns with perinatal @entity4 and XXXX in the first 12 hours of life and long-term prognosis.

answer: @entity5


abstract: @entity5 and II are diverse and quite frequent. After @entity2 , the virus establishes a life-long latency in the sensory ganglia and recrudescences may occur at an unpredictable rate. Recurrent @entity2 represent the majority of clinical manifestations of @entity5 . Their management is currently well established using evidence-based medicine data. Primary @entity6 is generally not treated with antivirals in otherwise healthy @entity0 , although intravenous @entity4 may be offered in severe primary @entity2 , particularly in the immunocompromised @entity0 . The decision whether or not to treat recurrent @entity6 should be evaluated individually and depends on the frequency and severity of relapses, the impairment of the quality of life, and the cost of therapy. @entity0 with mild disease may benefit from topical therapy, and those with severe and frequent recurrences may be considered for intermittent or long-term oral antiviral therapy. Primary @entity8 is treated with oral or intravenous antivirals, depending on the severity of the @entity2 and associated symptoms. Recurrent @entity8 can be managed with episodic short courses of oral antivirals in @entity0 whose recurrences are moderate to severe and rare, and have a clear prodrome. @entity0 with >5 episodes/year, severe recurrences or unrecognisable prodromes may be best managed with long-term suppressive antiviral prophylaxis. @entity3 is also responsible for a variety of other clinical manifestations, including herpetic @entity2 , disseminated and atypical @entity2 , @entity1 , @entity9 , and @entity3 -associated @entity7 . @entity5 may also represent a complication following cosmetic procedures of the oro-facial region, surgical and dental interventions, sun exposure and burns. Precise treatment guidelines for these @entity5 are not firmly established.

title: Treatment of mucocutaneous presentations of XXXX .

answer: @entity5


abstract: The @entity1 @entity3 (PR) has proved to be a good target for antiretroviral therapy of @entity0 , and various PR inhibitors are now in clinical use. However, there is a rapid selection of viral variants bearing mutations in the @entity3 that are resistant to clinical inhibitors. Drug resistance also involves mutations of the nucleocapsid/p1 and p1/p6 cleavage sites of @entity2 , both in vitro and in vivo. Cleavages at these sites have been shown to be rate limiting steps for polyprotein processing and viral maturation. Furthermore, these sites show significant sequence polymorphism, which also may have an impact on virion infectivity. We have studied the hydrolysis of oligopeptides representing these cleavage sites with representative mutations found as natural variations or that arise as resistant mutations. Wild-type and five drug resistant PRs with mutations within or outside the substrate binding site were tested. While the natural variations showed either increased or decreased susceptibility of peptides toward the proteinases, the resistant mutations always had a beneficial effect on catalytic efficiency. Comparison of the specificity changes obtained for the various substrates suggested that the maximization of the van der Waals contacts between substrate and @entity3 is the major determinant of specificity: the same effect is crucial for inhibitor potency. The natural nucleocapsid/p1 and p1/p6 sites do not appear to be optimized for rapid hydrolysis. Hence, mutation of these rate limiting cleavage sites can partly compensate for the reduced catalytic activity of drug resistant mutant @entity1 proteinases.

title: Effect of sequence polymorphism and drug resistance on two @entity1 XXXX processing sites.

answer: @entity2


abstract: The @entity1 @entity3 (PR) has proved to be a good target for antiretroviral therapy of @entity0 , and various PR inhibitors are now in clinical use. However, there is a rapid selection of viral variants bearing mutations in the @entity3 that are resistant to clinical inhibitors. Drug resistance also involves mutations of the nucleocapsid/p1 and p1/p6 cleavage sites of @entity2 , both in vitro and in vivo. Cleavages at these sites have been shown to be rate limiting steps for polyprotein processing and viral maturation. Furthermore, these sites show significant sequence polymorphism, which also may have an impact on virion infectivity. We have studied the hydrolysis of oligopeptides representing these cleavage sites with representative mutations found as natural variations or that arise as resistant mutations. Wild-type and five drug resistant PRs with mutations within or outside the substrate binding site were tested. While the natural variations showed either increased or decreased susceptibility of peptides toward the proteinases, the resistant mutations always had a beneficial effect on catalytic efficiency. Comparison of the specificity changes obtained for the various substrates suggested that the maximization of the van der Waals contacts between substrate and @entity3 is the major determinant of specificity: the same effect is crucial for inhibitor potency. The natural nucleocapsid/p1 and p1/p6 sites do not appear to be optimized for rapid hydrolysis. Hence, mutation of these rate limiting cleavage sites can partly compensate for the reduced catalytic activity of drug resistant mutant @entity1 proteinases.

title: Effect of sequence polymorphism and drug resistance on two XXXX @entity2 processing sites.

answer: @entity1


abstract: We assessed the value of bone marrow biopsy prospectively in a group of 91 individuals with @entity1 . The median age of our population was 29 years (range 4-87 years); 59 were males. Most @entity0 (45%) had nodular sclerosing disease and most @entity0 (44%) were in pathological stage II at diagnosis. The bone marrow biopsy showed infiltration by @entity1 in only three individuals (3.3%); two of these @entity0 displayed constitutional symptoms and had been assigned to stage III before the biopsy. In one case, bone marrow biopsy was the diagnostic procedure, which was performed as part of the investigation of fever of unknown origin. Follow-up periods ranged between 1 and 117 months (median 16 months). All @entity0 achieved complete remission, seven @entity0 relapsed and four were given autologous stem cell transplants. The median survival of the whole group was 117 months, while the 3500-day survival was 76%. As bone marrow biopsy was the diagnostic procedure in one case, bone marrow biopsy was a useful staging procedure in only 2.2% of @entity0 (two out of 90 @entity0 ). We suggest that bone marrow biopsy should be only be performed as a staging procedure in a selected subset of @entity0 with @entity1 (clinical stage III, B symptoms, etc.).

title: Role of bone marrow examination in staging XXXX : experience in M  xico.

answer: @entity1