abstract: BACKGROUND: Plantar @entity1 is a common illness with significant impact on quality of life. @entity4 presents good short-term results, but longer follow-up results are lacking. We evaluated @entity4 effectiveness in @entity0 who were not surgically treated and who had at least six  months of follow-up. METHODS: From September 2007 to September 2013, 85 consecutive @entity0 were enrolled in our institutional protocol for the "pharmacological-first" treatment of @entity1 with @entity4 . Eight @entity0 were lost to follow-up, 15 @entity0 have not yet been under treatment for six  months, and data were available for 39 @entity0 (all female) treated for at least six  months. Data at the start of the protocol, six  weeks after beginning treatment, and at their final visit were analyzed. RESULTS: Twenty-three of the 77 @entity0 (29.87%) did not improve after pharmacological therapy. From the 39 @entity0 with more than six  months of follow-up (median 16.9  months, range 9-71), 79.5% reported moderate/great improvement in @entity2 after six  weeks of treatment, and this rate increased to 84.7% in the last follow-up visit; 82.85% showed improvement in other sites presenting @entity1 . @entity3 was the most common side effect; 51.6% of @entity0 reported it to be moderate/severe at the last visit. CONCLUSION: In @entity0 with good initial response to @entity4 , more than 82% presented moderate or great improvement in plantar and other sites' excessive sweating; @entity3 was the most common side effect but was tolerable and did not lead any @entity0 to interrupt treatment.

title: Long-term results of the use of @entity4 for the treatment of XXXX .

answer: @entity1


abstract: BACKGROUND: Plantar @entity1 is a common illness with significant impact on quality of life. @entity4 presents good short-term results, but longer follow-up results are lacking. We evaluated @entity4 effectiveness in @entity0 who were not surgically treated and who had at least six  months of follow-up. METHODS: From September 2007 to September 2013, 85 consecutive @entity0 were enrolled in our institutional protocol for the "pharmacological-first" treatment of @entity1 with @entity4 . Eight @entity0 were lost to follow-up, 15 @entity0 have not yet been under treatment for six  months, and data were available for 39 @entity0 (all female) treated for at least six  months. Data at the start of the protocol, six  weeks after beginning treatment, and at their final visit were analyzed. RESULTS: Twenty-three of the 77 @entity0 (29.87%) did not improve after pharmacological therapy. From the 39 @entity0 with more than six  months of follow-up (median 16.9  months, range 9-71), 79.5% reported moderate/great improvement in @entity2 after six  weeks of treatment, and this rate increased to 84.7% in the last follow-up visit; 82.85% showed improvement in other sites presenting @entity1 . @entity3 was the most common side effect; 51.6% of @entity0 reported it to be moderate/severe at the last visit. CONCLUSION: In @entity0 with good initial response to @entity4 , more than 82% presented moderate or great improvement in plantar and other sites' excessive sweating; @entity3 was the most common side effect but was tolerable and did not lead any @entity0 to interrupt treatment.

title: Long-term results of the use of XXXX for the treatment of @entity1 .

answer: @entity4


abstract: UNASSIGNED: Objective: Several studies have reported on injury of the corticoreticular pathway in @entity0 with @entity1 and @entity2 . However, little is known about injury of the corticoreticular pathway in @entity0 with @entity4 . The aim of the current study was to investigate corticoreticular pathway injury in @entity0 with @entity4 . Design: Comparative study. Subjects: Among 137 @entity0 with @entity4 , 17 @entity0 with @entity3 who showed intact integrity of the corticospinal tract were recruited. Methods: Motricity Index was used for measurement of motor function. The fractional anisotropy value, apparent diffusion coefficient value, fibre volume, and integrity of the corticoreticular pathway were used for the diffusion tensor imaging parameters. Results: Twelve (70.6%) of 17 @entity0 and 18 (52.9%) of 34 hemispheres showed a discontinuation of the corticoreticular pathway at the midbrain level. The contralateral shoulder, hip, and lower extremity of the discontinued corticoreticular pathway showed lower motor functions, in comparison with those of the contralateral side of the intact corticoreticular pathway (p   <   0.05). By contrast, the Motricity Index for distal joint, upper and total Motricity Index were not different irrespective of the state of the corticoreticular pathway (p   >   0.05). Conclusion: Corticoreticular pathway injury is common in @entity0 with @entity3 after @entity4 , and it appears to be related to @entity3 in the contralateral shoulder, hip and lower extremity.

title: Injury of the corticoreticular pathway in XXXX after rupture of a cerebral artery aneurysm.

answer: @entity4


abstract: UNASSIGNED: Reaching and grasping parameters with and without haptic feedback were characterized in @entity0 with @entity1 . Twelve (67    10yrs) individuals with @entity1 and arm/hand paresis (Fugl-Meyer Assessment-Arm: >=  46/66 pts) participated. Three dimensional (3D) temporal and spatial kinematics of reaching and grasping movements to 3 objects (can: cylindrical grasp; screwdriver: power grasp; pen: precision grasp) in a @entity2 ( @entity2 ) with and without additional haptic feedback and a 3D virtual environment (VE) with haptic feedback were recorded. @entity0 reached, grasped and transported physical and virtual objects using similar movement strategies in all conditions. Reaches made in VE were less smooth and slower compared to the @entity2 . Arm and trunk kinematics were similar in both environments and glove conditions. For grasping, @entity1 subjects preserved aperture scaling to object size but used wider hand apertures with longer delays between times to maximal reaching velocity and maximal grasping aperture. Wearing the glove decreased reaching velocity. Our results in a small group of subjects suggest that providing haptic information in the VE did not affect the validity of reaching and grasping movement. Small disparities in movement parameters between environments may be due to differences in perception of object distance in VE. Reach-to-grasp kinematics to smaller objects may be improved by better 3D rendering. Comparable kinematics between environments and conditions is encouraging for the incorporation of high quality VEs in rehabilitation programs aimed at improving upper limb recovery.

title: Quality of Grasping and the Role of Haptics in a 3D Immersive Virtual Reality Environment in Individuals With XXXX .

answer: @entity1


abstract: Breakdown of the balance between maternal pro- and anti-inflammatory pathways is thought to allow an anti-fetal maternal immune response that underlies development of @entity0 . @entity0 is manifested by the influx of maternal inflammatory cells, including lymphocytes, histiocytes, and plasma cells, into the placental membranes, villi, and decidua. These infiltrates are recognized pathologically as chronic @entity6 , @entity1 of unknown etiology, and chronic deciduitis. Each of these histological entities is associated with adverse fetal outcomes including intrauterine growth restriction and @entity4 . Studying the gene expression patterns in chronically inflamed placenta, particularly when overlapping histologies are present, may lead to a better understanding of the underlying mechanism(s). Therefore, this study compared tissue with and without @entity0 , manifested as overlapping chronic @entity6 , @entity1 of unknown etiology, and chronic deciduitis. RNA expression profiling was conducted on @entity3 fixed, paraffin embedded placental tissue using Illumina microarrays. @entity10 was the most significant differentially expressed gene identified and had increased expression in the inflamed tissue. In addition, @entity11 , @entity9 , @entity5 , @entity2 , @entity8 , and @entity7 had increased expression in the inflamed placental samples. These differentially expressed genes are associated with T follicular helper cells, natural killer cells, and B cells. Furthermore, these genes differ from those typically associated with the individual components of @entity0 , such as @entity1 , suggesting that the inflammatory infiltrate associated with overlapping chronic @entity6 , @entity1 of unknown etiology, and chronic deciduitis differs is unique. To further explore and validate gene expression findings, we conducted immunohistochemical assessment of protein level expression and demonstrate that @entity10 expression was largely attributable to the presence of plasma cells as part of chronic deciduitis and that IgA positive plasma cells are associated with chronic deciduitis occurring in combination with chronic @entity6 and @entity1 of unknown etiology but not with isolated chronic deciduitis.

title: Overlap XXXX Is Associated with a Unique Gene Expression Pattern.

answer: @entity0


abstract: @entity2 ( @entity3 ) are widely distributed and relocated in the environment as a result of the incomplete combustion of organic matter. Many @entity3 and their @entity11 are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher systems including @entity0 . BP is one of the most toxicologically active @entity3 and is often used as a prototype for this entire class of contaminants. In order to select anti-BP antibodies, the conjugate of BP with BSA (BP-BSA) was used to screen na  ve combinatorial phage library of @entity0 scFvs. Seven unique scFvs against BP-BSA were selected after three rounds of selection. Analysis of the genes encoding the scFvs subdivided them to gene families and subfamilies. Homology with the closest germline ranged from 80.21% to 97.57% for heavy chains and 88.89% to 98.57% for the light chains. Four of the seven @entity9 @entity6 residues sequences without stop codons in frame were selected for proteomic analysis with each other. Four scFvs encoded unique non-related proteins with low-sequence identity among them. All CDRs and the boundaries in the @entity4 formation were carried out. Two of the scFvs (T68 and T72) with the highest binding capabilities to @entity3 were expressed in @entity1 and purified using a @entity5 resin. The KDs of T68 to BP-BSA, @entity10 , @entity7 , and @entity8 were almost similar, approximately 10(-7   )M. The KDs of T72 to @entity8 and @entity10 were 9.42   *   10(-8   )M and 2.63   *   10(-7   )M, respectively. The computational models of T68 and T72 active centers were different.

title: Generation and Characterization of @entity0 Single-Chain Antibodies Against XXXX .

answer: @entity2


abstract: @entity2 ( @entity3 ) are widely distributed and relocated in the environment as a result of the incomplete combustion of organic matter. Many @entity3 and their @entity11 are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher systems including @entity0 . BP is one of the most toxicologically active @entity3 and is often used as a prototype for this entire class of contaminants. In order to select anti-BP antibodies, the conjugate of BP with BSA (BP-BSA) was used to screen na  ve combinatorial phage library of @entity0 scFvs. Seven unique scFvs against BP-BSA were selected after three rounds of selection. Analysis of the genes encoding the scFvs subdivided them to gene families and subfamilies. Homology with the closest germline ranged from 80.21% to 97.57% for heavy chains and 88.89% to 98.57% for the light chains. Four of the seven @entity9 @entity6 residues sequences without stop codons in frame were selected for proteomic analysis with each other. Four scFvs encoded unique non-related proteins with low-sequence identity among them. All CDRs and the boundaries in the @entity4 formation were carried out. Two of the scFvs (T68 and T72) with the highest binding capabilities to @entity3 were expressed in @entity1 and purified using a @entity5 resin. The KDs of T68 to BP-BSA, @entity10 , @entity7 , and @entity8 were almost similar, approximately 10(-7   )M. The KDs of T72 to @entity8 and @entity10 were 9.42   *   10(-8   )M and 2.63   *   10(-7   )M, respectively. The computational models of T68 and T72 active centers were different.

title: Generation and Characterization of XXXX Single-Chain Antibodies Against @entity2 .

answer: @entity0


abstract: Thirteen @entity0 underwent renal exploration with nephroscopy to localize and to treat chronic unilateral gross @entity3 . Recurrent episodes of clot colic were noted in 6 @entity0 , 1 required multiple transfusions and persistent fears of @entity1 or problems with insurability prompted several @entity0 to seek referral. All @entity0 had undergone @entity2 studies, urine culture, cytology, excretory urograms, retrograde pyelograms and selective renal angiography. These studies either were normal or failed to identify the @entity2 source. Nephroscopy was recommended after failure of conservative treatments. At operative nephroscopy, done after preliminary cytoscopy to confirm active @entity2 , the @entity2 sites were identified in all our @entity0 . Discrete @entity4 were found in 5 @entity0 and the @entity2 could be localized to 1 calix in 7 others. Of our @entity0 12 underwent partial nephrectomy and 1 had a nephrectomy. To date there has been no recurrence of @entity2 in any of these @entity0 . Despite careful histological examination microscopic @entity4 could be found in only 6 of our specimens. Chronic gross @entity3 can be disabling physically and emotionally. In most, if not all, such cases judicious renal exploration with nephroscopy is warranted and cure can be expected with conservative partial nephrectomy.

title: Nephroscopy in chronic unilateral XXXX .

answer: @entity3


abstract: A 15-year experience with intracavitary radiation for the treatment of selected @entity2 is presented. The age range of these @entity0 was 39 to 91 years, with an average of 65 years. There were 38 @entity0 and 17 @entity0 with multiple stage A @entity2 and @entity3 . Some @entity0 were poor risks for treatment by total extirpative surgery. A simplified technique using a 25 mg. @entity4 capsule as a central source is described for administration of 4,000 to 5,000 rad to the surface of the bladder. Most @entity0 tolerate the presence of the radium catheter with little difficulty. No morbidity and no mortality were reported. In this series more than 60 per cent of the @entity0 benefited from the therapy, with no recurrence noted in some cases after up to 8 1/2 years of followup. Intracavitary radiation is used in few clinics. Use of this modality does not preclude or complicate the subsequent use of other conservative measures or radical therapy if required. It is an effective procedure for treatment of multiple superficial and noninvasive @entity1 , including primary or recurrent @entity3 , that are uncontrolled by other conservative measures.

title: Update on intracavitary radiation in the treatment of XXXX .

answer: @entity2


abstract: OBJECTIVE: To determine the scan delay for use in performing cardiac CT angiography in @entity0 . ANIMALS: 4 clinically normal adult Beagles. PROCEDURES: In a crossover study, 12 formulations of @entity3 solutions differing in @entity1 dose (300, 400, and 800 mg/kg) and concentration (undiluted and diluted 1:1, 1:2, and 1:3 with saline [0.9% @entity2 ] solution) were administered IV to each @entity0 . Dynamic CT angiography was performed to evaluate enhancement characteristics of each formulation, with the region of interest set over the aorta. Time-attenuation curves (TACs) were obtained and analyzed. RESULTS: Peak arc-type TACs were obtained after administration of all undiluted formulations. Curve shape changed from peak arc type to plateau type as the total volume of the contrast solution (ie, dilution) increased. Prolonged peaks characteristic of plateau-type TACs suggested that a sufficient period of homogeneous attenuation could be achieved for CT scanning with administration of higher @entity3 dilutions (1:2 or 1:3) containing higher @entity1 doses (400 or 800 mg/kg). In particular, attenuation values for plateau-type TACs remained between 200 and 300 Hounsfield units for > 16 seconds after the plateau endpoint was reached for 1:2 and 1:3 dilutions containing an @entity1 dose of 800 mg/kg. Scan delays of 13 to 17 seconds were computed for those 2 formulations. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that for clinically normal @entity0 , a scan delay of 13 to 17 seconds could be used to perform cardiac CT angiography with @entity3 solutions containing an @entity1 dose of 800 mg/kg at dilutions of 1:2 or 1:3.

title: Dynamic computed tomographic determination of scan delay for use in performing cardiac angiography in clinically normal XXXX .

answer: @entity0


abstract: UNASSIGNED: Difficulties in setting healthcare priorities are encountered throughout the world. There is no agreement on the most appropriate principles or methods for healthcare rationing although there is some consensus that it should be undertaken as systematically and accountably as possible. Although some steps towards achieving accountability have been made at the macro and meso level, at the consultation level rationing remains implicit and poorly understood. Using morbid @entity1 surgery as a case study, we observed a series of UK National Health Service consultations where rationing was ongoing and conducted in-depth interviews with doctors and @entity0 (2011-2014). A longitudinal approach was taken to research and in total 22 consultations were observed and 78 interviews were undertaken. Sampling was undertaken purposively and theoretically and analyses were undertaken thematically. Clinicians needed to prioritise 55 @entity0 from 450 eligible referrals, but disagreed over the extent to which clinical and financial factors were the driving force behind decision-making. The most prominent rationing technique observed in consultations was rationing by selection, but examples of rationing by delay, by deterrence, and by deflection were also commonplace. Although all clinicians sought to avoid rationing by denial, only six of the 22 @entity0 recruited to the research were known to have been treated at the end of the three-year period. Most clinicians sought to manage rationing implicitly, and only one explained the link between decision-making criteria and financial constraints on care availability. Although existing frameworks for categorising @entity2 rationing techniques were useful in identifying implicit strategies, in practice these techniques over-lapped substantially and we have proposed a simpler framework for analysing @entity2 rationing decisions at the consultation level, which includes just three categories - rationing by exclusion, rationing by deterrence, and rationing by delay.

title: How clinical rationing works in practice: A case study of morbid XXXX surgery.

answer: @entity1


abstract: AIMS: Branch @entity8 (BRVO) leads to @entity9 and is important cause of @entity3 . Although the vascular morphological changes following experimental @entity8 have been described in a variety of models using angiography, the underlying cellular events are ill defined. METHODS AND RESULTS: We here show that laser-induced experimental BRVO in @entity1 leads to a wave of TUNEL-positive endothelial cell (EC) apoptosis in the upstream vascular network associated with a transient @entity0 and @entity6 . Subsequently, we observe an induction of EC proliferation within the dilated vein and capillaries, detected by @entity10 incorporation, and the @entity0 resolves. However, the pericytes of the upstream capillaries are severely reduced, which was associated with continuing EC apoptosis and proliferation. The vascular remodeling was associated with increased expression of @entity7 , @entity12 , but also @entity11 expression. Exposure of the experimental animals to @entity5 , when pericyte (PC) dropout had occurred, led to a dramatic increase in endothelial cell proliferation, confirming the vascular instability induced by the experimental BRVO. CONCLUSION: Experimental BRVO leads to acute endothelial cells apoptosis and increased permeability. Subsequently the upstream vascular network remains destabilized, characterized by pericyte dropout, un-physiologically high endothelial cells turnover and sensitivity to @entity5 . These early changes might pave the way for @entity4 and subsequent chronic @entity2 and @entity0 that characterize the late stage disease.

title: Experimental Branch Retinal XXXX Induces Upstream Pericyte Loss and Vascular Destabilization.

answer: @entity8


abstract: INTRODUCTION: The low anterior rectal resection and double stapling technique are well-established surgical procedures with well-known pitfalls, potential complications, and preventive measures. @entity2 is a surgical error which should not occur. PRESENTATION OF CASE: A 39-year old @entity0 underwent low anterior resection with double stapling technique, for @entity1 in the City Hospital. On the fifth postoperative day she noticed passage of gas and two days later passage of feces from vagina. The surgeons who performed the operation explained to her that it is a normal condition for such modern procedure that is supervised by international educator engaged by the Government. The @entity0 lived with this condition, passage of gas and feces from the vagina and nothing from anus for three months when her oncologist referred her for a second opinion at the University Clinic for Digestive Surgery. The digital examinations revealed @entity4 , and feces in vagina; thus having the @entity0 's history in mind, we assumed that the @entity0 had a colovaginal @entity2 . Our assumption was confirmed by two succeeding radiological examinations. Initially, water soluble contrast enema was performed to assess the colon, when a clear-cut blind rectal stump was detected. Afterwards, the vaginography revealed a copious flow of contrast material from the vagina toward the sigmoid colon. After a few days, a restorative surgery was done. DISCUSSION: Most of the early @entity3 are a result of surgical errors. CONCLUSION: We believe that there is no excuse for such a surgical error and postoperative follow-up.

title: XXXX : A totally unacceptable surgical error.

answer: @entity2


abstract: @entity5 transferases (GST) are phase II enzymes catalyzing the detoxification of endogenous noxious compounds and xenobiotics. They also regulate phosphorylation activities of MAPKinases in a catalytic-independent manner. Previous studies have demonstrated the regulation of @entity13 -dependent pathway by @entity15 . Considering the crucial role of @entity13 in the early steps of the hepatocyte cell cycle, we sought to determine whether @entity15 were essential for hepatocyte proliferation following partial hepatectomy (PH). Using a conventional double knockout @entity0 model for the @entity16 and @entity17 genes, we found that the lack of @entity16 reduced the rate of DNA replication and mitotic index during the first wave of hepatocyte proliferation. The lowered proliferation was associated with the decrease in @entity1 and @entity2 plasma concentrations, reduced hepatic @entity12 expression and delayed and/or altered activation of @entity8 , @entity13 and @entity6 signaling pathways. In addition, the expression and/or activation of cell cycle regulators such as @entity4 , @entity10 , @entity9 and @entity11 was postponed demonstrating that the absence of @entity15 delayed the entry into and progression through the G1 phase of the cell cycle and impaired the synchrony of proliferation in hepatocytes following PH. Furthermore, while @entity13 and its downstream targets @entity7 and @entity14 were activated during the early steps of the liver regeneration in wild-type animals, the constitutively active @entity13 found in the quiescent liver of @entity15 knockout @entity0 underwent a decrease in its activity after PH. Transient induction of antioxidant enzymes and @entity3 synthase were also delayed or repressed during the regenerative response. Altogether our results demonstrate that @entity15 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration.

title: XXXX transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during @entity0 liver regeneration.

answer: @entity5


abstract: @entity5 transferases (GST) are phase II enzymes catalyzing the detoxification of endogenous noxious compounds and xenobiotics. They also regulate phosphorylation activities of MAPKinases in a catalytic-independent manner. Previous studies have demonstrated the regulation of @entity13 -dependent pathway by @entity15 . Considering the crucial role of @entity13 in the early steps of the hepatocyte cell cycle, we sought to determine whether @entity15 were essential for hepatocyte proliferation following partial hepatectomy (PH). Using a conventional double knockout @entity0 model for the @entity16 and @entity17 genes, we found that the lack of @entity16 reduced the rate of DNA replication and mitotic index during the first wave of hepatocyte proliferation. The lowered proliferation was associated with the decrease in @entity1 and @entity2 plasma concentrations, reduced hepatic @entity12 expression and delayed and/or altered activation of @entity8 , @entity13 and @entity6 signaling pathways. In addition, the expression and/or activation of cell cycle regulators such as @entity4 , @entity10 , @entity9 and @entity11 was postponed demonstrating that the absence of @entity15 delayed the entry into and progression through the G1 phase of the cell cycle and impaired the synchrony of proliferation in hepatocytes following PH. Furthermore, while @entity13 and its downstream targets @entity7 and @entity14 were activated during the early steps of the liver regeneration in wild-type animals, the constitutively active @entity13 found in the quiescent liver of @entity15 knockout @entity0 underwent a decrease in its activity after PH. Transient induction of antioxidant enzymes and @entity3 synthase were also delayed or repressed during the regenerative response. Altogether our results demonstrate that @entity15 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration.

title: @entity5 transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during XXXX liver regeneration.

answer: @entity0


abstract: Multipotent stem cells have potential therapeutic roles in the treatment of @entity3 ( @entity3 ). However, the limited access to stem cell sources restricts their clinical application. To address this issue, we established a simple in vitro epigenetic reprogramming technique in which skin fibroblasts are induced to dedifferentiate into multipotent cells. In this study, @entity0 fibroblasts were isolated from circumcised adult foreskin and were reprogrammed by co-culture for 72 h with fish oocyte extract (FOE) in serum-free medium. The cells were then observed and analyzed by immunofluorescence staining, flow cytometry and in vitro differentiation assays. Then FOE-treated @entity0 fibroblasts were transplanted by tail vein injection into irradiated mdx @entity1 , an animal model of @entity3 . Two months after injection, the therapeutic effects of FOE-treated fibroblasts on mdx skeletal muscle were evaluated by serum @entity2 kinase (CK) activity measurements and by immunostaining and RT-PCR of @entity0 @entity5 expression. The results indicated that the reprogrammed fibroblasts expressed higher levels of the pluripotent antigen markers SSEA-4, @entity4 and @entity6 , and were able to differentiate in vitro into adipogenic cells, osteoblastic cells, and myotube-like cells. Tail vein injection of FOE-treated fibroblasts into irradiated mdx @entity1 slightly reduced serum CK activity and the percentage of centrally nucleated myofibers two months after cell transplantation. Furthermore, we confirmed @entity0 @entity5 protein and mRNA expression in mdx @entity1 skeletal muscle. These data demonstrated that FOE-treated fibroblasts were multipotent and could integrate into mdx @entity1 myofibers through the vasculature.

title: In vitro and in vivo analysis of XXXX fibroblast reprogramming and multipotency.

answer: @entity0


abstract: UNASSIGNED: How to properly manage neuroendocrine liver @entity1 (NELM) remains debatable, and only limited clinical data have been published from Asian population. The objective of this study is to identify possible prognostic factors affecting overall survival time and to provide a guideline for future clinical practice.A retrospective study was performed on 1286 @entity0 who had @entity2 in our specialized center, and data from 130 @entity0 who had NELM were summarized. Demographic and clinicopathologic data, @entity2 grade, treatment method, and prognosis were statistically analyzed.Most of the NELMs originated from pancreas (65.4%). Important prognostic factors that included @entity2 location and size were identified with multivariate analysis. @entity0 with either @entity2 resection or liver @entity1 resection showed a 5-year survival of 35.7% or 33.3%, respectively, whereas resection of both resulted in a 50% 5-year survival. More importantly, resection was performed on 7 @entity0 with grade 3 (G3) @entity2 , and resulted in 1-year, 3-year, and 5-year survival of 100%, 42.8%, and 28.6%, respectively, whereas the other 9 G3 @entity0 without resection died within 3 years. P=0.49 comparing the resected group with nonresected group in G3 @entity0 . Besides, the overall 5-year survival rates for resected and nonresected @entity0 were 40.5% and 5.4%, respectively.Multiple prognostic factors influenced the overall outcome of NELM including @entity0 age, @entity2 location, and size, etc. Aggressive surgical approaches could be considered for maximum survival time disregarding the pathological grade of the @entity2 . Study with larger sample size should be considered to reevaluate the recommendation of the WHO guidelines for G3 @entity2 .

title: Surgical Resection Improves the Outcome of the XXXX With Neuroendocrine Tumor Liver Metastases: Large Data From Asia.

answer: @entity0


abstract: 1. @entity4 ( @entity5 ) and @entity7 ions ( @entity6 ), which block voltage-dependent @entity3 channels in other nerve membranes, have been used to study nerve conduction in fibres of normal @entity2 spinal roots and those demyelinated with @entity8 toxin. The pharmacological actions have been compared with those of temperature. 2. Both @entity6 and @entity5 increased the amplitude and duration of the monophasically recorded compound action potentials of non-myelinated fibres in normal @entity2 dorsal roots. Enhancement of the action potential amplitude by @entity5 was maximal near 1 mM, and was not readily reversed by washing. At concentrations up to 50 mM the action of @entity6 was weaker and reversible. 3. In normal dorsal and ventral roots @entity6 (20 mM) and @entity5 (5 mM) had only a mildly depressant action on the compound action potentials of myelinated fibres. Whereas the slight reduction in peak amplitude and increase in width was also found in a single fibres treated with @entity6 , none was discerned in single fibres exposed to @entity5 over a wide temperature range. 4. It is concluded that voltage-dependent @entity3 channels occur in significant numbers in @entity0 non-myelinated fibres, but not at nodes of Ranvier. 5. Spinal roots previously treated with @entity8 toxin to cause @entity1 were studied by longitudinal current analysis. Fibres affected by @entity8 toxin had a late phase of outward current, either restricted to nodes or, in the case of continuous conduction, distributed along internodes, and this outward current was specifically blocked by @entity5 . 6. Both @entity5 and @entity6 increased the temperature at which conduction block occurred in most single demyelinated fibres, so that in some cases fibres blocked at physiological temperatures were enabled to conduct. @entity5 was more potent than @entity6 , but less consistent in its effect. 7. It is concluded that @entity3 channels are present at widened nodes and in internodal axolemma exposed by @entity1 . Their presence enables @entity6 and @entity5 to overcome conduction block in some @entity1 .

title: The effects of XXXX and @entity7 ions on normal and demyelinated @entity0 nerve fibres.

answer: @entity4


abstract: 1. @entity4 ( @entity5 ) and @entity7 ions ( @entity6 ), which block voltage-dependent @entity3 channels in other nerve membranes, have been used to study nerve conduction in fibres of normal @entity2 spinal roots and those demyelinated with @entity8 toxin. The pharmacological actions have been compared with those of temperature. 2. Both @entity6 and @entity5 increased the amplitude and duration of the monophasically recorded compound action potentials of non-myelinated fibres in normal @entity2 dorsal roots. Enhancement of the action potential amplitude by @entity5 was maximal near 1 mM, and was not readily reversed by washing. At concentrations up to 50 mM the action of @entity6 was weaker and reversible. 3. In normal dorsal and ventral roots @entity6 (20 mM) and @entity5 (5 mM) had only a mildly depressant action on the compound action potentials of myelinated fibres. Whereas the slight reduction in peak amplitude and increase in width was also found in a single fibres treated with @entity6 , none was discerned in single fibres exposed to @entity5 over a wide temperature range. 4. It is concluded that voltage-dependent @entity3 channels occur in significant numbers in @entity0 non-myelinated fibres, but not at nodes of Ranvier. 5. Spinal roots previously treated with @entity8 toxin to cause @entity1 were studied by longitudinal current analysis. Fibres affected by @entity8 toxin had a late phase of outward current, either restricted to nodes or, in the case of continuous conduction, distributed along internodes, and this outward current was specifically blocked by @entity5 . 6. Both @entity5 and @entity6 increased the temperature at which conduction block occurred in most single demyelinated fibres, so that in some cases fibres blocked at physiological temperatures were enabled to conduct. @entity5 was more potent than @entity6 , but less consistent in its effect. 7. It is concluded that @entity3 channels are present at widened nodes and in internodal axolemma exposed by @entity1 . Their presence enables @entity6 and @entity5 to overcome conduction block in some @entity1 .

title: The effects of @entity4 and XXXX ions on normal and demyelinated @entity0 nerve fibres.

answer: @entity7


abstract: 1. @entity4 ( @entity5 ) and @entity7 ions ( @entity6 ), which block voltage-dependent @entity3 channels in other nerve membranes, have been used to study nerve conduction in fibres of normal @entity2 spinal roots and those demyelinated with @entity8 toxin. The pharmacological actions have been compared with those of temperature. 2. Both @entity6 and @entity5 increased the amplitude and duration of the monophasically recorded compound action potentials of non-myelinated fibres in normal @entity2 dorsal roots. Enhancement of the action potential amplitude by @entity5 was maximal near 1 mM, and was not readily reversed by washing. At concentrations up to 50 mM the action of @entity6 was weaker and reversible. 3. In normal dorsal and ventral roots @entity6 (20 mM) and @entity5 (5 mM) had only a mildly depressant action on the compound action potentials of myelinated fibres. Whereas the slight reduction in peak amplitude and increase in width was also found in a single fibres treated with @entity6 , none was discerned in single fibres exposed to @entity5 over a wide temperature range. 4. It is concluded that voltage-dependent @entity3 channels occur in significant numbers in @entity0 non-myelinated fibres, but not at nodes of Ranvier. 5. Spinal roots previously treated with @entity8 toxin to cause @entity1 were studied by longitudinal current analysis. Fibres affected by @entity8 toxin had a late phase of outward current, either restricted to nodes or, in the case of continuous conduction, distributed along internodes, and this outward current was specifically blocked by @entity5 . 6. Both @entity5 and @entity6 increased the temperature at which conduction block occurred in most single demyelinated fibres, so that in some cases fibres blocked at physiological temperatures were enabled to conduct. @entity5 was more potent than @entity6 , but less consistent in its effect. 7. It is concluded that @entity3 channels are present at widened nodes and in internodal axolemma exposed by @entity1 . Their presence enables @entity6 and @entity5 to overcome conduction block in some @entity1 .

title: The effects of @entity4 and @entity7 ions on normal and demyelinated XXXX nerve fibres.

answer: @entity0


abstract: BACKGROUND: @entity7 ( @entity7 ) often represent a challenge for clinicians, because clinical, laboratory and even genetic features are not always sufficient to distinguish among different @entity7 . OBJECTIVES: The aim of this study was to investigate the pathogenetic mechanisms underlying an acute case of TMA with features of both @entity5 and @entity3 . @entity0 /METHODS: We report the case of a 49-year-old @entity0 who developed an acute TMA with neurologic involvement and no @entity1 . @entity4 , @entity6 and complement-system biochemical characterization was performed on acute phase samples. Exome sequencing and direct Sanger sequencing of previously aHUS-associated genes were performed. The functional consequences of the @entity8 ( @entity8 ) mutation were investigated by in vitro expression studies. RESULTS: Despite a clinical diagnosis of @entity5 , the @entity0 had normal @entity4 levels and increased @entity6 antigen levels with ultra-large @entity6 multimers. C3, @entity10 (CFI) were normal. Molecular analysis confirmed two novel heterozygous mutations in CFI ( @entity11 , @entity9 ) and @entity8 ( @entity12 , @entity13 ) and in vitro expression studies showed a reduction in the generation of TAFIa caused by mutated @entity8 . This pro-inflammatory condition, associated with the @entity9 mutation in CFI, probably leads to a complement-mediated endothelial activation, with a relevant prothrombotic potential in case of transient environmental triggers. CONCLUSIONS: This study identified the first case of acute TMA without @entity1 but with @entity2 carrying two novel mutations in complement-regulator genes, highlighting the possible role of the complement system as a common pathogenetic mechanism in @entity7 . This article is protected by copyright. All rights reserved.

title: A case report of @entity7 without XXXX carrying two novel mutations in complement-regulator genes.

answer: @entity1


abstract: BACKGROUND: @entity7 ( @entity7 ) often represent a challenge for clinicians, because clinical, laboratory and even genetic features are not always sufficient to distinguish among different @entity7 . OBJECTIVES: The aim of this study was to investigate the pathogenetic mechanisms underlying an acute case of TMA with features of both @entity5 and @entity3 . @entity0 /METHODS: We report the case of a 49-year-old @entity0 who developed an acute TMA with neurologic involvement and no @entity1 . @entity4 , @entity6 and complement-system biochemical characterization was performed on acute phase samples. Exome sequencing and direct Sanger sequencing of previously aHUS-associated genes were performed. The functional consequences of the @entity8 ( @entity8 ) mutation were investigated by in vitro expression studies. RESULTS: Despite a clinical diagnosis of @entity5 , the @entity0 had normal @entity4 levels and increased @entity6 antigen levels with ultra-large @entity6 multimers. C3, @entity10 (CFI) were normal. Molecular analysis confirmed two novel heterozygous mutations in CFI ( @entity11 , @entity9 ) and @entity8 ( @entity12 , @entity13 ) and in vitro expression studies showed a reduction in the generation of TAFIa caused by mutated @entity8 . This pro-inflammatory condition, associated with the @entity9 mutation in CFI, probably leads to a complement-mediated endothelial activation, with a relevant prothrombotic potential in case of transient environmental triggers. CONCLUSIONS: This study identified the first case of acute TMA without @entity1 but with @entity2 carrying two novel mutations in complement-regulator genes, highlighting the possible role of the complement system as a common pathogenetic mechanism in @entity7 . This article is protected by copyright. All rights reserved.

title: A case report of XXXX without @entity1 carrying two novel mutations in complement-regulator genes.

answer: @entity7


abstract: UNASSIGNED: Nanoscopic synchrotron X-ray imaging was performed on scalp hair samples of @entity1 with @entity0 and healthy individuals to investigate any structural differences as diagnostic tool. Hair strands were divided into 2-3 segments along the strands from root to tip, followed by imaging either in projection or in CT scanning with a monochromatic 6.78-keV X-ray using zone-plate optics with a resolving power of 60 nm. All the examined @entity2 hairs exhibited medulla loss with @entity2 stage-dependent pattern; complete loss, discontinuous or trace along the strands. In contrast, medullas were well retained without complete loss in the healthy hair. In the CT-scanned axial images, the cortical spindle compartments had no contrast in the healthy hair, but appeared hypointense in contrast to the surrounding hyperintense cortical membrane complex in the @entity2 hair. In conclusion, observation of medulla loss and cortical membrane enhancements in the hair strands of @entity0 @entity1 @entity2 hair, providing a new platform for further synchrotron X-ray imaging study of screening @entity0 @entity1 . Microsc. Res. Tech., 2015.    2015 Wiley Periodicals, Inc.

title: Synchrotron nanoscopy imaging study of scalp hair in XXXX @entity1 and healthy individuals: Difference in medulla loss and cortical membrane enhancements.

answer: @entity0


abstract: UNASSIGNED: Nanoscopic synchrotron X-ray imaging was performed on scalp hair samples of @entity1 with @entity0 and healthy individuals to investigate any structural differences as diagnostic tool. Hair strands were divided into 2-3 segments along the strands from root to tip, followed by imaging either in projection or in CT scanning with a monochromatic 6.78-keV X-ray using zone-plate optics with a resolving power of 60 nm. All the examined @entity2 hairs exhibited medulla loss with @entity2 stage-dependent pattern; complete loss, discontinuous or trace along the strands. In contrast, medullas were well retained without complete loss in the healthy hair. In the CT-scanned axial images, the cortical spindle compartments had no contrast in the healthy hair, but appeared hypointense in contrast to the surrounding hyperintense cortical membrane complex in the @entity2 hair. In conclusion, observation of medulla loss and cortical membrane enhancements in the hair strands of @entity0 @entity1 @entity2 hair, providing a new platform for further synchrotron X-ray imaging study of screening @entity0 @entity1 . Microsc. Res. Tech., 2015.    2015 Wiley Periodicals, Inc.

title: Synchrotron nanoscopy imaging study of scalp hair in @entity0 XXXX and healthy individuals: Difference in medulla loss and cortical membrane enhancements.

answer: @entity1


abstract: @entity2 of the aqueduct of Sylvius accounts for about one third of cases of @entity5 . At least 32 families have been reported in which the @entity5 is inherited in an X linked fashion. In half of these families, flexed adducted thumbs were noted in some affected family members. Occasionally other male members were @entity3 , suggesting limited expression of the gene. The problem of giving genetic advice to an isolated, clinically unremarkable, case of @entity5 remains, so a family study was undertaken based on 24 such cases seen at The Hospital for Sick @entity0 over a 19-year period. There were 15 male and nine female index @entity0 . The diagnosis was confirmed in all cases by air encephalogram. One @entity0 had a radial club hand and another developed clasped thumbs secondary to @entity1 . No cases had @entity4 . The 15 @entity0 had 18 brothers and 19 sisters, of whom one sister was similarly affected. The nine @entity0 had 12 sibs, none of whom was affected. This study, combined with a similar study in the USA, suggests that the empirical risk of recurrence of a sporadic case of @entity5 is about 4.5%.

title: A family study of @entity5 resulting from XXXX .

answer: @entity5


abstract: @entity2 of the aqueduct of Sylvius accounts for about one third of cases of @entity5 . At least 32 families have been reported in which the @entity5 is inherited in an X linked fashion. In half of these families, flexed adducted thumbs were noted in some affected family members. Occasionally other male members were @entity3 , suggesting limited expression of the gene. The problem of giving genetic advice to an isolated, clinically unremarkable, case of @entity5 remains, so a family study was undertaken based on 24 such cases seen at The Hospital for Sick @entity0 over a 19-year period. There were 15 male and nine female index @entity0 . The diagnosis was confirmed in all cases by air encephalogram. One @entity0 had a radial club hand and another developed clasped thumbs secondary to @entity1 . No cases had @entity4 . The 15 @entity0 had 18 brothers and 19 sisters, of whom one sister was similarly affected. The nine @entity0 had 12 sibs, none of whom was affected. This study, combined with a similar study in the USA, suggests that the empirical risk of recurrence of a sporadic case of @entity5 is about 4.5%.

title: A family study of XXXX resulting from @entity5 .

answer: @entity5


abstract: BACKGROUND: This study presents the preliminary results of a new arthroscopic technique consisting of the association of 2 procedures, capsulolabral repair and subscapularis augmentation tenodesis, in the treatment of traumatic anterior shoulder instability with both glenoid @entity1 and a @entity2 . METHODS: Eighty-nine @entity0 engaged in sports were enrolled in this retrospective case-series study with 2 to 5  years' follow-up. All @entity0 underwent a computed tomography scan to assess the percentage of glenoid @entity1 by the Pico method. A prior stabilization procedure had failed in 20 @entity0 , who were then segregated into a different group. Visual analog scale (VAS), Rowe, and American Shoulder and Elbow Surgeons (ASES) scores were used to assess the results. RESULTS: Only 3 of 89 @entity0 had a post-traumatic redislocation. The mean length of follow-up was 31.5  months (range, 25-60  months). The VAS, Rowe, and ASES scores showed significant improvements: The VAS score decreased from a mean of 3.1 to 0.5 (P  =  .0157), the Rowe score increased from 58.9 to 94.1 (P  =  .0215), and the ASES score increased from 68.5 to 95.5 (P  =  .0197). The mean deficit of external rotation was 6   with the arm at the side of the trunk, and the mean deficit was 3   with the arm in 90   of abduction. CONCLUSIONS: The described procedure is a reproducible and effective technique used to restore joint stability in @entity0 engaged in sports who have incurred anterior recurrent @entity3 associated with glenoid @entity1 (<25%) and a @entity2 .

title: Arthroscopic Bankart repair and subscapularis augmentation: an alternative technique treating anterior shoulder instability with XXXX .

answer: @entity1


abstract: BACKGROUND AND STUDY AIMS: Hepatic hydatid cyst is a major health problem in endemic areas. Surgery is still the best choice for treatment of the hydatid @entity1 . However, it is still associated with high mortality and morbidity. The aim of the study was to evaluate the predictive factors for specific morbidity after conservative surgical treatment of the hydatid @entity1 . @entity0 AND METHODS: A total of 120 @entity0 who underwent conservative surgical treatment between 2001 and 2011 were evaluated retrospectively. RESULTS: Of the 120 @entity0 , 64 were female subjects and 56 male subjects; the median age was 33years (14-83years). The mortality rate was 0%. The overall morbidity rate was 26.6%. The specific morbidity rate was 16.6%. The major specific complications were @entity2 of the residual cavity in 10 cases and an external @entity3 in eight cases. The predictive factors of morbidity in univariate analysis were bilious cyst content, location of the cyst in the hepatic dome, and size >10cm. After multivariate analysis, only the size of the cyst was an independent predictive factor of morbidity. CONCLUSION: The size of the cyst was the significant predictor of morbidity of conservative surgery for liver hydatid cyst.

title: Predictive factors of morbidity after surgical treatment of hydatid XXXX .

answer: @entity1


abstract: INTRODUCTION: In TNM classification, factors determining the @entity1 ( @entity1 ) component in @entity3 have scarcely changed over time and are still based solely on anatomical features. Our objective was to study the influence of these and other morphopathological factors on survival. METHODS: A total of 263 @entity0 undergoing lung resection due to stage I @entity3  <=3cm in diameter were studied. A survival analysis and competing-risk estimate study was made on the basis of clinical, surgical and pathological variables using actuarial analysis and accumulative incidence methods, respectively. A risk model was then generated from the results. RESULTS: Survival at 5 and 10 years was 79.8 and 74.3%, respectively. The best prognostic factors were presence of symptoms, smoking habit and FEV1>60%, number of resected nodes>7, squamous histology, @entity4 , absence of visceral pleural invasion and presence of invasion more proximal than the lobar bronchus. All these were statistically significant according to the actuarial method. The factor "age<50 years" was close to the margin of statistical significance. Pleural invasion and vascular invasion were entered in the multivariate analysis. The competing-risk analysis showed a probability of @entity2 due to @entity1 of 14.3 and 35.1% at 5 and 10 years, respectively. Significant variables in the univariate and multivariate analyses were similar, with the exception of FEV1>60%. CONCLUSIONS: Pleural invasion and vascular invasion determine survival or risk of @entity2 due to @entity3  <=3cm and can be used for generating a predictive risk model.

title: Prognostic Factors in XXXX Less Than 3 Centimeters: Actuarial Analysis, Accumulative Incidence and Risk Groups.

answer: @entity3


abstract: Nanofibrillar cellulose is a very promising innovation with diverse potential applications including high quality paper, coatings, and drug delivery carriers. The production of nanofibrillar cellulose on an industrial scale may lead to increased exposure to nanofibrillar cellulose both in the working environment and the general environment. Assessment of the potential health effects following exposure to nanofibrillar cellulose is therefore required. However, as nanofibrillar cellulose primarily consists of @entity1 moieties, detection of nanofibrillar cellulose in biological tissues is difficult. We have developed a simple and robust method for specific and sensitive detection of cellulose fibers, including nanofibrillar cellulose, in biological tissue, using a biotinylated @entity4 binding module (CBM) of b-1,4-glycanase (EXG:CBM) from the bacterium @entity5 . EXG:CBM was expressed in @entity2 , purified, and biotinylated. EXG:CBM was shown to bind quantitatively to five different cellulose fibers including four different nanofibrillar celluloses. Biotinylated EXG:CBM was used to visualize cellulose fibers by either fluorescence- or @entity3 radish peroxidase (HRP)-tagged avidin labeling. The HRP-EXG:CBM complex was used to visualize cellulose fibers in both cryopreserved and paraffin embedded lung tissue from @entity0 dosed by pharyngeal aspiration with 10-200  g/ @entity0 . Detection was shown to be highly specific, and the assay appeared very robust. The present method represents a novel concept for the design of simple, robust, and highly specific detection methods for the detection of nanomaterials, which are otherwise difficult to visualize.

title: Visualization of Nanofibrillar Cellulose in Biological Tissues Using a Biotinylated XXXX Binding Module of b-1,4-Glycanase.

answer: @entity4


abstract: Dentally induced stress and relaxation-induced @entity2 recently have been correlated with salivary changes in private @entity0 treated by a solo endodontist. Hypnosis was shown to be more effective than local anesthesia in @entity2 . Dental students and clinic @entity0 were employed in this study in an attempt to replicate the previous findings. One additional salivary variable (pH) was examined. Twenty-nine endodontic clinic @entity0 were treated, each by a different dental student. The @entity0 completed dental @entity2 questionnaires and had salivary samples taken prior to, and at the conclusion of, their initial endodontic treatments. @entity3 and @entity2 were managed using local anesthesia, hypnosis, or @entity4 - @entity1 , either alone or in combination. There were significant @entity2 changes by the conclusion of the visits (p less than 0.001) as measured by increased salivary volume, increased salivary translucency, reduced salivary protein, increased salivary pH and reduced questionnaire-determined @entity2 level. Hypnosis and @entity4 - @entity1 were significantly more effective (p less than 0.05) than local anesthesia in @entity2 as measured by salivary changes and questionnaires. It can be concluded that saliva is an easily obtained fluid that can be used to determine levels of stress and relaxation.

title: Stress, relaxation and saliva: a follow-up study involving clinical endodontic XXXX .

answer: @entity0


abstract: @entity0 ( @entity0 ) of the colorectum is known as a rare variant with favorable prognosis despite its poorly differentiated morphology. The mechanism of its favorable behavior has been unclear. Here, we compared the expressions of adhesion molecules and epithelial-mesenchymal transition (EMT)-related proteins in the central portion and invasive front between 43 MCs and 30 @entity1 ( @entity1 ). The expressions of membranous @entity4 (P < .0001), @entity2 (P < .0001) and @entity3 (P = .0036) were significantly preserved in the invasive front of the MCs compared to those in the invasive front of the @entity1 . @entity4 membranous expression was also significantly preserved in the central portion of the MCs (P = .0178). Nuclear @entity2 expression in both the central portion (P = .0463) and invasive front (P = .0346) of the MCs was significantly less frequent compared to that in the @entity1 . Snail (P = .0035) and @entity5 (P = .0463) expressions in the invasive front of the MCs were significantly less frequent compared to the @entity1 , suggesting that the EMT phenomenon may occur rarely in colorectal @entity0 . Reduced membranous @entity4 expression in the @entity0 central portion was significantly correlated with poor clinical outcome (P = .0086). Our immunohistochemical results indicate that preserved adhesion molecule protein and less frequent expression of EMT-related transcription factors in the invasive front contribute to the favorable prognosis of colorectal MCs. We suggest that a reduced expression of @entity4 in the central portion might be a good biomarker for an unfavorable prognosis in cases of @entity0 .

title: Expression of adhesion molecules and epithelial-mesenchymal transition factors in XXXX of the colorectum.

answer: @entity0


abstract: BACKGROUND: Itching, burning, @entity4 and tingling of the skin are frequent reasons for dermatology consultation. We hypothesized that these sensations may be attributable to a small-fibre @entity1 . Sweating, which is mediated by small nerve fibres, may be a surrogate marker of small-fibre @entity1 . OBJECTIVES: To investigate the results of @entity2 ( @entity2 ), which depicts and estimates whole-body sweating, in @entity0 with itching, burning, @entity3 . METHODS: We retrospectively reviewed the medical records of 227 @entity0 with itching, burning, @entity3 involving the skin who were seen at our institution during 2008 and also underwent @entity2 . RESULTS: The mean age of the cohort was 54  years (range 3-89), and 58% were female. In all, 149 @entity0 (66%) had abnormal @entity2 results; in 119 (80%) of these @entity0 the areas of @entity5 on @entity2 corresponded to their symptomatic areas. For each symptom analysed separately, the area of @entity5 correlated with the area of symptoms in most @entity0 . CONCLUSIONS: @entity0 with burning, itching, @entity4 and tingling have abnormal sweating patterns and often do not sweat in the symptomatic areas. These novel findings suggest that a small-fibre @entity1 may underlie many cutaneous symptoms and that the @entity1 can be estimated using @entity2 .

title: Abnormal sweating patterns associated with itching, burning and tingling of the skin indicate possible underlying small-fibre XXXX .

answer: @entity1


abstract: UNASSIGNED: The purpose of this study was to clarify the effect of Chinese propolis on the expression level of neurotrophic factors in dental pulp cells (DPCs). We also investigated that the effects of the conditioned medium (CM) of DPCs stimulated by the propolis against oxidative and endoplasmic reticulum (ER) stresses in @entity0 @entity4 SH-SY5Y cells, and on @entity5 extensions in @entity1 adrenal pheochromocytoma PC12 cells. To investigate the effect of the propolis on the levels of neurotrophic factors in DPCs, we performed a qRT-PCR experiment. As results, NGF, but not @entity6 and NT-3, in DPCs was significantly elevated by the propolis in a concentration-dependent manner. @entity3 -induced cell death was significantly inhibited by the treatment with the @entity8 . In addition, the treatment with the propolis-stimulated @entity8 had a more protective effect than that with the @entity8 . We also examine the effect of the propolis-stimulated @entity8 against a @entity7 -induced ER stress. The treatment with the propolis-stimulated CM as well as the @entity8 significantly inhibited @entity7 -induced cell death. Moreover, the treatment with the propolis-stimulated @entity8 significantly induced @entity5 outgrowth from PC12 cells than that with the @entity8 . These results suggest that the @entity8 as well as DPCs will be an efficient source of new treatments for @entity2 and that the propolis promote the advantage of the @entity8 via producing neurotrophic factors.

title: Conditioned medium of dental pulp cells stimulated by Chinese propolis show neuroprotection and XXXX extension in vitro.

answer: @entity5


abstract: BACKGROUND: Case series suggest that laparoscopic peritoneal lavage might be a promising alternative to sigmoidectomy in @entity0 with @entity5 . We aimed to assess the superiority of laparoscopic lavage compared with sigmoidectomy in @entity0 with purulent @entity5 , with respect to overall long-term morbidity and mortality. METHODS: We did a multicentre, parallel-group, randomised, open-label trial in 34 teaching hospitals and eight academic hospitals in Belgium, Italy, and the Netherlands (the Ladies trial). The Ladies trial is split into two groups: the LOLA group comparing laparoscopic lavage with sigmoidectomy and the DIVA group comparing Hartmann's procedure with sigmoidectomy plus primary @entity1 . The DIVA section of this trial is still underway but here we report the results of the LOLA section. @entity0 with purulent @entity5 were enrolled for LOLA, excluding @entity0 with @entity2 , aged older than 85 years, with high-dose @entity3 use (>= 20 mg daily), and @entity4 . @entity0 were randomly assigned (2:1:1; stratified by age [<60 years vs >= 60 years]) using secure online computer randomisation to laparoscopic lavage, Hartmann's procedure, or primary @entity1 in a parallel design after diagnostic laparoscopy. @entity0 were analysed according to a modified intention-to-treat principle and were followed up after the index operation at least once in the outpatient setting and after sigmoidoscopy and stoma reversal, according to local protocols. The primary endpoint was a composite endpoint of major morbidity and mortality within 12 months. This trial is registered with ClinicalTrials.gov, number NCT01317485. FINDINGS: Between July 1, 2010, and Feb 22, 2013, 90 @entity0 were randomly assigned in the LOLA section of the Ladies trial when the study was terminated by the data and safety monitoring board because of an increased event rate in the lavage group. Two @entity0 were excluded for protocol violations. The primary endpoint occurred in 30 (67%) of 45 @entity0 in the lavage group and 25 (60%) of 42 @entity0 in the sigmoidectomy group (odds ratio 1  28, 95% CI 0  54-3  03, p=0  58). By 12 months, four @entity0 had died after lavage and six @entity0 had died after sigmoidectomy (p=0  43). INTERPRETATION: Laparoscopic lavage is not superior to sigmoidectomy for the treatment of purulent @entity5 . FUNDING: Netherlands Organisation for Health Research and Development.

title: Laparoscopic peritoneal lavage or sigmoidectomy for @entity5 with XXXX : a multicentre, parallel-group, randomised, open-label trial.

answer: @entity2


abstract: BACKGROUND: Case series suggest that laparoscopic peritoneal lavage might be a promising alternative to sigmoidectomy in @entity0 with @entity5 . We aimed to assess the superiority of laparoscopic lavage compared with sigmoidectomy in @entity0 with purulent @entity5 , with respect to overall long-term morbidity and mortality. METHODS: We did a multicentre, parallel-group, randomised, open-label trial in 34 teaching hospitals and eight academic hospitals in Belgium, Italy, and the Netherlands (the Ladies trial). The Ladies trial is split into two groups: the LOLA group comparing laparoscopic lavage with sigmoidectomy and the DIVA group comparing Hartmann's procedure with sigmoidectomy plus primary @entity1 . The DIVA section of this trial is still underway but here we report the results of the LOLA section. @entity0 with purulent @entity5 were enrolled for LOLA, excluding @entity0 with @entity2 , aged older than 85 years, with high-dose @entity3 use (>= 20 mg daily), and @entity4 . @entity0 were randomly assigned (2:1:1; stratified by age [<60 years vs >= 60 years]) using secure online computer randomisation to laparoscopic lavage, Hartmann's procedure, or primary @entity1 in a parallel design after diagnostic laparoscopy. @entity0 were analysed according to a modified intention-to-treat principle and were followed up after the index operation at least once in the outpatient setting and after sigmoidoscopy and stoma reversal, according to local protocols. The primary endpoint was a composite endpoint of major morbidity and mortality within 12 months. This trial is registered with ClinicalTrials.gov, number NCT01317485. FINDINGS: Between July 1, 2010, and Feb 22, 2013, 90 @entity0 were randomly assigned in the LOLA section of the Ladies trial when the study was terminated by the data and safety monitoring board because of an increased event rate in the lavage group. Two @entity0 were excluded for protocol violations. The primary endpoint occurred in 30 (67%) of 45 @entity0 in the lavage group and 25 (60%) of 42 @entity0 in the sigmoidectomy group (odds ratio 1  28, 95% CI 0  54-3  03, p=0  58). By 12 months, four @entity0 had died after lavage and six @entity0 had died after sigmoidectomy (p=0  43). INTERPRETATION: Laparoscopic lavage is not superior to sigmoidectomy for the treatment of purulent @entity5 . FUNDING: Netherlands Organisation for Health Research and Development.

title: Laparoscopic peritoneal lavage or sigmoidectomy for XXXX with @entity2 : a multicentre, parallel-group, randomised, open-label trial.

answer: @entity5


abstract: BACKGROUND: Risk stratification in @entity5 ( @entity5 ) remains controversial. The time interval between the peak and the end of the T wave (Tpe interval), a marker of transmural dispersion of repolarization, has been linked to @entity1 in various settings but leads to discordant results in @entity5 . OBJECTIVE: We study the correlation of the Tpe interval with arrhythmic events in a large cohort of @entity0 with @entity5 . METHODS: A total of 325 consecutive @entity0 with @entity5 (mean age 47  13 years, 259 @entity0 -80%) with spontaneous (n=143, 44%) or drug-induced (n=182, 56%) type 1 electrocardiogram were retrospectively included. 235 were asymptomatic (70%), 80 presented with unexplained @entity4 (22%), and 10 presented with @entity2 ( @entity2 ) or appropriate implantable cardioverter-defibrillator therapy ( @entity3 ) (8%) at diagnosis or over a mean follow-up of 48    34 months. The Tpe interval was calculated as the difference between the QT interval and the QT peak interval as measured in each of the precordial leads. RESULTS: The Tpe interval from lead V1 to lead V4, maximum value of the Tpe interval (max Tpe), and Tpe dispersion in all precordial leads were significantly higher in @entity0 with @entity2 / @entity3 or in @entity0 with @entity4 than in asymptomatic @entity0 (P < .001). A max Tpe of >= 100 ms was present in 47 of 226 asymptomatic @entity0 (21%), in 48 of 73 @entity0 with @entity4 (66%), and in 22 of 26 @entity0 with @entity2 / @entity3 (85%) (P < .0001). In multivariate analysis, a max Tpe of >= 100 ms was independently related to arrhythmic events (odds ratio 9.61; 95% confidence interval 3.13-29.41; P < .0001). CONCLUSION: The Tpe interval in the precordial leads is highly related to @entity1 in this large cohort of @entity0 with @entity5 . This simple electrocardiographic parameter could be used to refine risk stratification.

title: Increased Tpeak-Tend interval is highly and independently related to arrhythmic events in XXXX .

answer: @entity5


abstract: OBJECTIVE: The objective is to review the evidence evaluating the efficacy of statin therapy for primary prevention of @entity1 in the elderly. Data Sources: A literature search of MEDLINE and PubMed (1966-January 2013) using the terms HMG-CoA reductase inhibitor, statin, primary prevention, elderly, and geriatrics was performed. The search was limited to clinical trials, meta-analyses, and subanalyses, including primary prevention @entity0 . Bibliographies of selected articles were examined to identify additional clinical trials. Study Selection: Fourteen clinical trials, subanalyses, and meta-analyses were reviewed. A total of seven clinical trials and subanalyses evaluating statin therapy versus placebo in the elderly primary prevention @entity0 with a primary endpoint of hard @entity2 were included. DATA EXTRACTION: Data collected from the clinical trials and subanalyses included number of elderly @entity0 randomized, therapy, duration of follow-up, and the incidence of coronary events. DATA SYNTHESIS: The average annual rates of first CV event increases as @entity0 age. There is strong evidence that supports the use of statins for secondary prevention; although primary prevention, specifically in the elderly, is less defined. This paper reviews the literature specifically for primary prevention, for which the results have shown a trend toward decreased first occurrence of @entity2 with statin therapy in elderly @entity0 . CONCLUSION: Statin therapy should be considered as a primary prevention therapy against @entity2 for elderly @entity0 . Evidence-based clinical benefits are seen in this @entity0 population. However, clinical judgment and consideration of comorbidities that may impact life expectancy should be assessed to determine appropriateness for individual @entity0 .

title: Statins for the Primary Prevention of XXXX in the Elderly.

answer: @entity1


abstract: OBJECTIVES: Early-course @entity4 have been extensively studied in terms of phenomenology, but little is known about the influence of personality traits on clinical features of first-episode @entity3 . The aim of this study was to explore how the "big five" personality domains ( @entity2 , extraversion, @entity5 , agreeableness, and conscientiousness) are associated with treatment delay (duration of untreated @entity3 , DUP), functioning, and positive and negative symptom severity. METHODS: Data for these analyses were obtained from 104 @entity0 enrolled from @entity1 inpatient units in Atlanta, Georgia, between August 2008 and March 2011. The NEO Five-Factor Inventory (NEO-FFI) was used to assess personality domains, and all other variables were measured in a standardized and rigorous manner using psychometrically sound instruments. Correlational analyses and multiple linear regressions were carried out to examine the strength of associations between variables of interest. RESULTS: Findings indicated that except for @entity5 , all of the other personality variables contributed to some extent to the variance in DUP. Conscientiousness was positively correlated with functioning. Agreeableness was independently negatively associated with positive symptom severity and extraversion was independently negatively correlated with negative symptom severity. CONCLUSIONS: We report the first evidence suggesting that DUP is in part driven by personality domains. Functioning and symptom severity are also associated with those domains. Personality should be taken into account in order to better understand the phenomenology of early-course @entity4 as well as treatment-seeking behaviors.

title: Personality domains, duration of untreated XXXX , functioning, and symptom severity in first-episode @entity3 .

answer: @entity3


abstract: OBJECTIVES: Early-course @entity4 have been extensively studied in terms of phenomenology, but little is known about the influence of personality traits on clinical features of first-episode @entity3 . The aim of this study was to explore how the "big five" personality domains ( @entity2 , extraversion, @entity5 , agreeableness, and conscientiousness) are associated with treatment delay (duration of untreated @entity3 , DUP), functioning, and positive and negative symptom severity. METHODS: Data for these analyses were obtained from 104 @entity0 enrolled from @entity1 inpatient units in Atlanta, Georgia, between August 2008 and March 2011. The NEO Five-Factor Inventory (NEO-FFI) was used to assess personality domains, and all other variables were measured in a standardized and rigorous manner using psychometrically sound instruments. Correlational analyses and multiple linear regressions were carried out to examine the strength of associations between variables of interest. RESULTS: Findings indicated that except for @entity5 , all of the other personality variables contributed to some extent to the variance in DUP. Conscientiousness was positively correlated with functioning. Agreeableness was independently negatively associated with positive symptom severity and extraversion was independently negatively correlated with negative symptom severity. CONCLUSIONS: We report the first evidence suggesting that DUP is in part driven by personality domains. Functioning and symptom severity are also associated with those domains. Personality should be taken into account in order to better understand the phenomenology of early-course @entity4 as well as treatment-seeking behaviors.

title: Personality domains, duration of untreated @entity3 , functioning, and symptom severity in first-episode XXXX .

answer: @entity3


abstract: BACKGROUND: Genome-wide association studies (GWAS) have so far reported 12 loci associated with @entity1 (EOC) risk. We hypothesized that some of these loci function through nearby transcription factor (TF) genes and that putative target genes of these TFs as identified by coexpression may also be enriched for additional EOC risk associations. METHODS: We selected TF genes within 1 Mb of the top signal at the 12 genome-wide significant risk loci. Mutual information, a form of correlation, was used to build networks of genes strongly coexpressed with each selected TF gene in the unified microarray dataset of 489 serous EOC tumors from The Cancer Genome Atlas. Genes represented in this dataset were subsequently ranked using a gene-level test based on results for germline SNPs from a serous EOC GWAS meta-analysis (2,196 cases/4,396 controls). RESULTS: Gene set enrichment analysis identified six networks centered on TF genes ( @entity5 , @entity4 , @entity2 , @entity6 at 17q21.32 and @entity7 , @entity3 at 2q31) that were significantly enriched for genes from the risk-associated end of the ranked list (P < 0.05 and FDR < 0.05). These results were replicated (P < 0.05) using an independent association study (7,035 cases/21,693 controls). Genes underlying enrichment in the six networks were pooled into a combined network. CONCLUSION: We identified a HOX-centric network associated with serous EOC risk containing several genes with known or emerging roles in serous EOC development. IMPACT: Network analysis integrating large, context-specific datasets has the potential to offer mechanistic insights into @entity0 susceptibility and prioritize genes for experimental characterization.

title: Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous XXXX Risk.

answer: @entity1


abstract: STUDY QUESTION: Can the luteal phase support be improved in terms of efficacy, hormonal profiles and convenience as compared with today's standard care? SUMMARY ANSWER: Daily low-dose rhCG supplementation in @entity2 triggered IVF cycles can replace the traditional used luteal phase support with exogenous @entity1 . WHAT IS KNOWN ALREADY: A bolus of hCG for final maturation of follicles in connection with @entity3 may induce the risk of @entity4 and the luteal phase @entity1 levels rise very abruptly in the early luteal phase. STUDY DESIGN, SIZE, DURATION: This is a proof-of-concept study conducted as a three arm RCT with a total of 93 @entity0 . First @entity0 enrolled in January 2012 and the study finished in January 2014. @entity0 /MATERIALS, SETTING, METHODS: Normal responder @entity0 undergoing IVF/ICSI treatment in a university hospital. One arm served as control, where @entity0 followed a standard antagonist protocol. Two study arms were included both having 125 IU hCG daily for luteal phase support without exogenous @entity1 after using a @entity2 trigger for ovulation induction. In both study arms exogenous FSH was stopped on stimulation day 6 and replaced by exogenous hCG that was initiated on either stimulation day 2 or day 6. Blood samples were obtained on the day of ovulation induction, on the day of oocyte pickup (OPU) and day OPU + 7. MAIN RESULTS AND THE ROLE OF CHANCE: The mean serum levels of hCG did not exceeded the normal physiological range of LH activity in any samples. Mid-luteal @entity1 levels were significantly higher in the two study groups receiving daily low-dose hCG for luteal phase support as compared with the control group (control group: 177    27 nmol/l; study group 1: 334    42 nmol/l; study group 2: 277    27 nmol/l; (mean    SEM). No differences in reproductive outcome were seen between groups. LIMITATIONS, REASONS FOR CAUTION: The number of @entity0 included is limited and conclusions need to be verified in a larger RCT. WIDER IMPLICATIONS OF THE FINDINGS: Endogenous production of @entity1 may become more attractive as the luteal phase support with levels of LH-like activity only in the physiological range and may, from the @entity0 ' point of view, replace inconvenient exogenous @entity1 preparation. Further hCG may reduce the cost of stimulation and may collectively be used for stimulation of the follicular phase, ovulation induction and for luteal phase support. STUDY FUNDING/COMPETING INTERESTS: An unrestricted grant from ARTS Biologics made this study possible. None of the authors has any competing interests to declare. TRIAL REGISTRATION NUMBER: ClinicalTrial.gov number: NCT01504139. TRIAL REGISTRATION DATE: 28 December 2011.

title: Daily low-dose hCG stimulation during the luteal phase combined with XXXX triggered IVF cycles without exogenous @entity1 : a proof of concept trial.

answer: @entity2


abstract: STUDY QUESTION: Can the luteal phase support be improved in terms of efficacy, hormonal profiles and convenience as compared with today's standard care? SUMMARY ANSWER: Daily low-dose rhCG supplementation in @entity2 triggered IVF cycles can replace the traditional used luteal phase support with exogenous @entity1 . WHAT IS KNOWN ALREADY: A bolus of hCG for final maturation of follicles in connection with @entity3 may induce the risk of @entity4 and the luteal phase @entity1 levels rise very abruptly in the early luteal phase. STUDY DESIGN, SIZE, DURATION: This is a proof-of-concept study conducted as a three arm RCT with a total of 93 @entity0 . First @entity0 enrolled in January 2012 and the study finished in January 2014. @entity0 /MATERIALS, SETTING, METHODS: Normal responder @entity0 undergoing IVF/ICSI treatment in a university hospital. One arm served as control, where @entity0 followed a standard antagonist protocol. Two study arms were included both having 125 IU hCG daily for luteal phase support without exogenous @entity1 after using a @entity2 trigger for ovulation induction. In both study arms exogenous FSH was stopped on stimulation day 6 and replaced by exogenous hCG that was initiated on either stimulation day 2 or day 6. Blood samples were obtained on the day of ovulation induction, on the day of oocyte pickup (OPU) and day OPU + 7. MAIN RESULTS AND THE ROLE OF CHANCE: The mean serum levels of hCG did not exceeded the normal physiological range of LH activity in any samples. Mid-luteal @entity1 levels were significantly higher in the two study groups receiving daily low-dose hCG for luteal phase support as compared with the control group (control group: 177    27 nmol/l; study group 1: 334    42 nmol/l; study group 2: 277    27 nmol/l; (mean    SEM). No differences in reproductive outcome were seen between groups. LIMITATIONS, REASONS FOR CAUTION: The number of @entity0 included is limited and conclusions need to be verified in a larger RCT. WIDER IMPLICATIONS OF THE FINDINGS: Endogenous production of @entity1 may become more attractive as the luteal phase support with levels of LH-like activity only in the physiological range and may, from the @entity0 ' point of view, replace inconvenient exogenous @entity1 preparation. Further hCG may reduce the cost of stimulation and may collectively be used for stimulation of the follicular phase, ovulation induction and for luteal phase support. STUDY FUNDING/COMPETING INTERESTS: An unrestricted grant from ARTS Biologics made this study possible. None of the authors has any competing interests to declare. TRIAL REGISTRATION NUMBER: ClinicalTrial.gov number: NCT01504139. TRIAL REGISTRATION DATE: 28 December 2011.

title: Daily low-dose hCG stimulation during the luteal phase combined with @entity2 triggered IVF cycles without exogenous XXXX : a proof of concept trial.

answer: @entity1


abstract: BACKGROUND: The purpose of this study was to examine associations of pretreatment serum carotenoids, @entity4 , and @entity3 with prognosis in 154 @entity0 newly diagnosed with @entity1 . METHODS: Pretreatment blood and health surveys were collected. Serum micronutrients were measured by high performance liquid chromatography. Data on recurrence and @entity2 were collected annually. Cox proportional hazards models measured associations of serum nutrient concentrations with recurrence and overall survival. RESULTS: During a median follow-up time of 37 months, there were 32 recurrences and 27 @entity2 . After controlling for covariates, subjects with high versus low serum xanthophyll and total carotenoid concentrations had significantly longer recurrence-free time (p   =   .002 and p   =   .02, respectively). Overall survival time was significantly longer in @entity0 with high versus low serum xanthophyll concentrations (p   =   .02). CONCLUSION: Future research should evaluate the possible benefits of interventions to increase intakes of rich food sources of @entity5 in this @entity0 population.    2015 Wiley Periodicals, Inc. Head Neck 38: E1591-E1597, 2016.

title: Pretreatment serum xanthophyll concentrations as predictors of XXXX recurrence and survival.

answer: @entity1


abstract: The lifetime risk of @entity5 ( @entity5 ) for @entity0 and @entity0 over the age of 40 is about 25%. The condition affects around 800,000 @entity0 in the UK, of which it is estimated that 250,000 are undiagnosed. A rapid heart rate may result in palpitations, dyspnoea or chest tightness, whereas loss of atrial contractility may lead to fatigue and reduced exercise capacity. There is a five-fold increased risk of @entity1 , transient @entity4 . @entity5 strokes are larger, more disabling and have a higher mortality rate than those with other causes. The risk of @entity1 is not related to the presence or absence of symptoms, or whether the @entity5 is paroxysmal or persistent. When an irregular pulse is detected it should precipitate further assessment with a 12-lead ECG. In @entity0 with intermittent palpitations that may represent @entity5 , prolonged ECG monitoring can be used to increase the chance of diagnosis. In @entity0 with a confirmed diagnosis of @entity5 , three areas need to be considered, @entity1 risk, symptoms, and risk of @entity3 . The CHA2DS2-VASc score is used to assess the @entity1 risk in @entity0 with @entity5 . Oral anticoagulation should be offered to those with a CHA2DS2-VASc score of 2 or more, and considered for @entity0 with a score of 1. The risk of severe @entity2 with warfarin should also be assessed using the HAS-BLED score. A score of 3 or more indicates that caution is required when starting any anticoagulant therapy. Oral anticoagulant therapy can reduce the risk of @entity1 by around 50-70%. It should be started when the @entity0 reaches 65 or if he/she develops any of the risk factors for @entity1 .

title: Have a high index of suspicion for XXXX .

answer: @entity5


abstract: A prospective study was designed to investigate the effects of recombinant @entity0 follicle-stimulating hormone (rhFSH) on seminal anti-M  llerian hormone ( @entity1 ) levels in @entity0 with idiopathic oligoasthenoteratozoospermia (iOAT), researching possible relationships between the seminal @entity1 behavior and the response to the treatment. Thirty-nine @entity0 who were candidates for intracytoplasmic sperm injection (ICSI) because of iOAT were enrolled. @entity0 were treated on alternately days with 150  IU of rhFSH for at least 3  months before assisted reproduction cycles. Main outcome measures were seminal @entity1 concentrations before and after rhFSH therapy. After treatment, 16 subjects (responders) showed an improvement in their sperm count compared to baseline (7.6      2.9 vs. 19.3      7.7, p  <  0.01) whereas 23 @entity0 (non-responders) experienced no sperm modifications. Baseline seminal @entity1 concentrations were significantly higher in responders than in non-responders (53.0      30.6 vs. 34.6      18.5, p  <  0.025). Following therapy, a greater increase in @entity1 levels was observed in responders compared to non-responders (    =  24.8      36.4 vs.     =  6.4      11.2, p  <  0.028). Seminal @entity1 levels significantly and positively correlated with sperm count (after rhFSH treatment rho  =  0.647, p  <  0.001). Our study suggests that rhFSH improves sperm count in a quota of iOAT @entity0 , and the subjects who respond to the treatment have higher baseline seminal @entity1 concentrations than the @entity0 who are not responsive. Seminal @entity1 could be helpful to select those infertile @entity0 who may benefit from rhFSH treatment.

title: Seminal anti-M  llerian hormone levels during recombinant XXXX follicle-stimulating hormone treatment in @entity0 with idiopathic infertility undergoing assisted reproduction cycles.

answer: @entity0


abstract: A prospective study was designed to investigate the effects of recombinant @entity0 follicle-stimulating hormone (rhFSH) on seminal anti-M  llerian hormone ( @entity1 ) levels in @entity0 with idiopathic oligoasthenoteratozoospermia (iOAT), researching possible relationships between the seminal @entity1 behavior and the response to the treatment. Thirty-nine @entity0 who were candidates for intracytoplasmic sperm injection (ICSI) because of iOAT were enrolled. @entity0 were treated on alternately days with 150  IU of rhFSH for at least 3  months before assisted reproduction cycles. Main outcome measures were seminal @entity1 concentrations before and after rhFSH therapy. After treatment, 16 subjects (responders) showed an improvement in their sperm count compared to baseline (7.6      2.9 vs. 19.3      7.7, p  <  0.01) whereas 23 @entity0 (non-responders) experienced no sperm modifications. Baseline seminal @entity1 concentrations were significantly higher in responders than in non-responders (53.0      30.6 vs. 34.6      18.5, p  <  0.025). Following therapy, a greater increase in @entity1 levels was observed in responders compared to non-responders (    =  24.8      36.4 vs.     =  6.4      11.2, p  <  0.028). Seminal @entity1 levels significantly and positively correlated with sperm count (after rhFSH treatment rho  =  0.647, p  <  0.001). Our study suggests that rhFSH improves sperm count in a quota of iOAT @entity0 , and the subjects who respond to the treatment have higher baseline seminal @entity1 concentrations than the @entity0 who are not responsive. Seminal @entity1 could be helpful to select those infertile @entity0 who may benefit from rhFSH treatment.

title: Seminal anti-M  llerian hormone levels during recombinant @entity0 follicle-stimulating hormone treatment in XXXX with idiopathic infertility undergoing assisted reproduction cycles.

answer: @entity0


abstract: OBJECTIVE: Diet therapy in @entity1 ( @entity1 ) has focused on @entity5 restriction but is poorly substantiated. In this pilot randomized clinical trial, we challenged the conventional low- @entity5 /higher-fat (LC/CONV) diet, hypothesizing that a higher-complex @entity5 /lower-fat (CHOICE) diet would improve maternal @entity6 resistance (IR), @entity4 ( @entity4 ) lipolysis, and @entity0 @entity4 . RESEARCH DESIGN AND METHODS: At 31 weeks, 12 diet-controlled overweight/ @entity2 @entity0 with @entity1 were randomized to an isocaloric LC/CONV (40% @entity5 /45% fat/15% protein; n = 6) or CHOICE (60%/25%/15%; n = 6) diet. All meals were provided. @entity4 was biopsied at 37 weeks. RESULTS: After    7 weeks, fasting @entity3 (P = 0.03) and @entity7 (P = 0.06) decreased on CHOICE, whereas fasting @entity3 increased on LC/CONV (P = 0.03). @entity6 suppression of @entity4 lipolysis was improved on CHOICE versus LC/CONV (56 vs. 31%, P = 0.005), consistent with improved IR. @entity4 expression of multiple proinflammatory genes was lower on CHOICE (P < 0.01). @entity0 @entity4 trended lower with CHOICE (10.1    1.4 vs. 12.6    2%, respectively). CONCLUSIONS: A CHOICE diet may improve maternal IR and @entity0 @entity4 , challenging recommendations for a LC/CONV diet.

title: @entity0 With Gestational Diabetes Randomized to a Higher-Complex @entity5 /Low-Fat Diet Manifest Lower Adipose Tissue @entity6 Resistance, Inflammation, XXXX , and Free Fatty Acids: A Pilot Study.

answer: @entity3


abstract: OBJECTIVE: Diet therapy in @entity1 ( @entity1 ) has focused on @entity5 restriction but is poorly substantiated. In this pilot randomized clinical trial, we challenged the conventional low- @entity5 /higher-fat (LC/CONV) diet, hypothesizing that a higher-complex @entity5 /lower-fat (CHOICE) diet would improve maternal @entity6 resistance (IR), @entity4 ( @entity4 ) lipolysis, and @entity0 @entity4 . RESEARCH DESIGN AND METHODS: At 31 weeks, 12 diet-controlled overweight/ @entity2 @entity0 with @entity1 were randomized to an isocaloric LC/CONV (40% @entity5 /45% fat/15% protein; n = 6) or CHOICE (60%/25%/15%; n = 6) diet. All meals were provided. @entity4 was biopsied at 37 weeks. RESULTS: After    7 weeks, fasting @entity3 (P = 0.03) and @entity7 (P = 0.06) decreased on CHOICE, whereas fasting @entity3 increased on LC/CONV (P = 0.03). @entity6 suppression of @entity4 lipolysis was improved on CHOICE versus LC/CONV (56 vs. 31%, P = 0.005), consistent with improved IR. @entity4 expression of multiple proinflammatory genes was lower on CHOICE (P < 0.01). @entity0 @entity4 trended lower with CHOICE (10.1    1.4 vs. 12.6    2%, respectively). CONCLUSIONS: A CHOICE diet may improve maternal IR and @entity0 @entity4 , challenging recommendations for a LC/CONV diet.

title: @entity0 With Gestational Diabetes Randomized to a Higher-Complex @entity5 /Low-Fat Diet Manifest Lower Adipose Tissue XXXX Resistance, Inflammation, @entity3 , and Free Fatty Acids: A Pilot Study.

answer: @entity6


abstract: OBJECTIVE: Diet therapy in @entity1 ( @entity1 ) has focused on @entity5 restriction but is poorly substantiated. In this pilot randomized clinical trial, we challenged the conventional low- @entity5 /higher-fat (LC/CONV) diet, hypothesizing that a higher-complex @entity5 /lower-fat (CHOICE) diet would improve maternal @entity6 resistance (IR), @entity4 ( @entity4 ) lipolysis, and @entity0 @entity4 . RESEARCH DESIGN AND METHODS: At 31 weeks, 12 diet-controlled overweight/ @entity2 @entity0 with @entity1 were randomized to an isocaloric LC/CONV (40% @entity5 /45% fat/15% protein; n = 6) or CHOICE (60%/25%/15%; n = 6) diet. All meals were provided. @entity4 was biopsied at 37 weeks. RESULTS: After    7 weeks, fasting @entity3 (P = 0.03) and @entity7 (P = 0.06) decreased on CHOICE, whereas fasting @entity3 increased on LC/CONV (P = 0.03). @entity6 suppression of @entity4 lipolysis was improved on CHOICE versus LC/CONV (56 vs. 31%, P = 0.005), consistent with improved IR. @entity4 expression of multiple proinflammatory genes was lower on CHOICE (P < 0.01). @entity0 @entity4 trended lower with CHOICE (10.1    1.4 vs. 12.6    2%, respectively). CONCLUSIONS: A CHOICE diet may improve maternal IR and @entity0 @entity4 , challenging recommendations for a LC/CONV diet.

title: @entity0 With Gestational Diabetes Randomized to a Higher-Complex XXXX /Low-Fat Diet Manifest Lower Adipose Tissue @entity6 Resistance, Inflammation, @entity3 , and Free Fatty Acids: A Pilot Study.

answer: @entity5


abstract: OBJECTIVE: Diet therapy in @entity1 ( @entity1 ) has focused on @entity5 restriction but is poorly substantiated. In this pilot randomized clinical trial, we challenged the conventional low- @entity5 /higher-fat (LC/CONV) diet, hypothesizing that a higher-complex @entity5 /lower-fat (CHOICE) diet would improve maternal @entity6 resistance (IR), @entity4 ( @entity4 ) lipolysis, and @entity0 @entity4 . RESEARCH DESIGN AND METHODS: At 31 weeks, 12 diet-controlled overweight/ @entity2 @entity0 with @entity1 were randomized to an isocaloric LC/CONV (40% @entity5 /45% fat/15% protein; n = 6) or CHOICE (60%/25%/15%; n = 6) diet. All meals were provided. @entity4 was biopsied at 37 weeks. RESULTS: After    7 weeks, fasting @entity3 (P = 0.03) and @entity7 (P = 0.06) decreased on CHOICE, whereas fasting @entity3 increased on LC/CONV (P = 0.03). @entity6 suppression of @entity4 lipolysis was improved on CHOICE versus LC/CONV (56 vs. 31%, P = 0.005), consistent with improved IR. @entity4 expression of multiple proinflammatory genes was lower on CHOICE (P < 0.01). @entity0 @entity4 trended lower with CHOICE (10.1    1.4 vs. 12.6    2%, respectively). CONCLUSIONS: A CHOICE diet may improve maternal IR and @entity0 @entity4 , challenging recommendations for a LC/CONV diet.

title: XXXX With Gestational Diabetes Randomized to a Higher-Complex @entity5 /Low-Fat Diet Manifest Lower Adipose Tissue @entity6 Resistance, Inflammation, @entity3 , and Free Fatty Acids: A Pilot Study.

answer: @entity0


abstract: UNASSIGNED: Altered diffusion in the normal appearing white matter (NAWM) of @entity2 @entity0 has been explained by @entity1 infiltration. The goal of the present study was to test this explanation indirectly by examining whether these alterations were also present in the contralateral NAWM of non-infiltrative @entity1 like @entity3 ; and to search for other possible reasons for this abnormality. Twenty-seven @entity0 with histologically verified @entity2 (grade II-IV), 22 @entity3 @entity0 and two groups of age- and sex-matched healthy controls underwent diffusion weighted imaging (DWI) on a 3T MR. All @entity0 were examined before treatment. Apparent diffusion coefficient (ADC) values were calculated in the entire NAWM of the hemisphere contralateral to the @entity1 . ADC values of the NAWM were compared between groups with Mann-Whitney U-test and multiple linear regression. The relations of ADC in NAWM to @entity2 grade and to @entity1 volume were also investigated. ADC values of the contralateral NAWM were significantly higher in both @entity2 and @entity3 @entity0 compared to controls (P  =  0.0006 and 0.0099, respectively). ADC value was higher in the NAWM of high grade @entity2 than in low grade @entity2 (P  =  0.0181) and in healthy control subjects (P  =  0.0003). ADC did not depend on @entity1 volume in any of the @entity0 groups. Elevated ADC in the NAWM of both @entity2 and @entity3 @entity0 might indicate that the effect of infiltrating @entity1 cells is not the only reason for the alteration as it has been previously suggested. Although the role of mass effect was not proved, other mechanisms might also contribute to ADC elevation.

title: Increased diffusion in the normal appearing white matter of brain tumor @entity0 : is this just XXXX infiltration?

answer: @entity1


abstract: UNASSIGNED: Altered diffusion in the normal appearing white matter (NAWM) of @entity2 @entity0 has been explained by @entity1 infiltration. The goal of the present study was to test this explanation indirectly by examining whether these alterations were also present in the contralateral NAWM of non-infiltrative @entity1 like @entity3 ; and to search for other possible reasons for this abnormality. Twenty-seven @entity0 with histologically verified @entity2 (grade II-IV), 22 @entity3 @entity0 and two groups of age- and sex-matched healthy controls underwent diffusion weighted imaging (DWI) on a 3T MR. All @entity0 were examined before treatment. Apparent diffusion coefficient (ADC) values were calculated in the entire NAWM of the hemisphere contralateral to the @entity1 . ADC values of the NAWM were compared between groups with Mann-Whitney U-test and multiple linear regression. The relations of ADC in NAWM to @entity2 grade and to @entity1 volume were also investigated. ADC values of the contralateral NAWM were significantly higher in both @entity2 and @entity3 @entity0 compared to controls (P  =  0.0006 and 0.0099, respectively). ADC value was higher in the NAWM of high grade @entity2 than in low grade @entity2 (P  =  0.0181) and in healthy control subjects (P  =  0.0003). ADC did not depend on @entity1 volume in any of the @entity0 groups. Elevated ADC in the NAWM of both @entity2 and @entity3 @entity0 might indicate that the effect of infiltrating @entity1 cells is not the only reason for the alteration as it has been previously suggested. Although the role of mass effect was not proved, other mechanisms might also contribute to ADC elevation.

title: Increased diffusion in the normal appearing white matter of brain tumor XXXX : is this just @entity1 infiltration?

answer: @entity0


abstract: BACKGROUND: In @entity0 diagnosed with @entity5 ( @entity5 ), the lungs are the most common site of @entity1 at both initial presentation and relapse. Previous studies have encouraged pulmonary metastasectomy to achieve a disease-free state after resection of the primary @entity2 . However, there is no consensus about how to manage recurrent @entity4 . PROCEDURE: A retrospective, multi-institutional review was performed from 2005 to 2014 to identify @entity5 @entity0  <=18years of age who had disease recurrence associated with pulmonary metastases alone. RESULTS: Ten @entity0 between the ages of 8 and 33months were identified. Pulmonary metastatic recurrence was detected by measuring @entity3 ( @entity3 ) levels and/or with CT scans of the chest. All @entity0 subsequently underwent pulmonary metastasectomy without post-operative complications. At last follow-up, 8 @entity0 were alive and had normal @entity3 levels. The 8 survivors had a median follow-up from therapy completion of 18.5months. Two @entity0 who presented with extrapulmonary recurrence subsequently died of treatment refractory disease. CONCLUSIONS: This review supports surgical resection as a safe and, in the context of multimodal therapy, efficacious approach to manage @entity5 @entity0 who present with isolated pulmonary relapse.

title: XXXX confined to the lung is effectively treated with pulmonary metastasectomy.

answer: @entity5


abstract: OBJECTIVES: The objective was to compare dentofacial characteristics of @entity2 in Saudi and Japanese adult females. MATERIALS AND METHODS: Lateral cephalograms of 50 Saudi adult female and 50 Japanese adult female (18-35-year-old) were obtained. All @entity0 were skeletal @entity2 , angle @entity2 , arch length discrepancy (-10-10 mm), overjet (1-5 mm), overbite (1-5 mm), absence of @entity1 , or significant @entity3 or congenitally missing tooth other than the 3(rd) molar and absence of temporomandibular joint problems. @entity0 cephalograms were traced and digitized. 16 angular measurements and 13 linear measurements of facial form were used. RESULTS: A comparison of the vertical dimension showed that the Saudi females had a significantly larger gonial angle, a significantly larger facial angle and longer lower face height compared to the Japanese females. Dentally, Saudi females had more protruded incisors with increased distances of the posterior teeth to the palatal plane. For the soft tissue dimension, the Saudi subjects had a significantly more prominent nose, retruded lip and a more protruded chin compared with Japanese. CONCLUSIONS: There were significant differences in dentofacial morphology between Saudi and Japanese adult females. Both Asian countries have distinct cephalometric features, which should be considered as a reference in treating @entity0 of varying ethnic backgrounds to optimize the final results.

title: Differences in dentofacial characteristics of XXXX between Saudi and Japanese adult females.

answer: @entity2