abstract: UNASSIGNED: OBJECT Approximately 10% of @entity0 with blunt traumatic @entity2 have a complete occlusion of the vertebral artery (VA). @entity3 due to embolization of @entity5 from an occluded VA following cervical spine surgery has been observed. The risk of @entity3 with cervical spine surgery in the presence of an occluded VA, however, has never been determined. METHODS A retrospective chart review of 52 @entity0 with a @entity4 following a @entity2 was performed. Clinical and radiographic characteristics were collected and analyzed. RESULTS Ten @entity0 (19.2%) suffered an @entity3 attributable to a traumatic @entity4 . Univariate analysis demonstrated that @entity0 with @entity3 were significantly older (p = 0.042) and had a lower rate of cervical spine surgery (p < 0.005). Multivariate analysis found cervical spine surgery to be protective against @entity3 (OR 0.049 [95% CI 0.014-0.167], p = 0.014); increasing age and bilateral @entity6 (bilateral occlusion or unilateral occlusion with contralateral dissection) were risk factors for @entity3 (OR 1.05 [95% CI1.02-1.07], p = 0.065 and OR 13.2 [95% CI 2.98-58.9], p = 0.084, respectively). CONCLUSIONS Traumatic @entity4 is associated with a risk of @entity3 and mortality. Corrective cervical spine surgery potentially decreases the risk of @entity3 by stabilizing the spine and thereby reducing motion across the occluded segment of the VA and preventing embolization of @entity5 . While a high stoke risk may be @entity1 , novel therapies should be investigated.

title: Corrective spinal surgery may be protective against stroke in @entity0 with blunt traumatic XXXX .

answer: @entity4


abstract: UNASSIGNED: OBJECT Approximately 10% of @entity0 with blunt traumatic @entity2 have a complete occlusion of the vertebral artery (VA). @entity3 due to embolization of @entity5 from an occluded VA following cervical spine surgery has been observed. The risk of @entity3 with cervical spine surgery in the presence of an occluded VA, however, has never been determined. METHODS A retrospective chart review of 52 @entity0 with a @entity4 following a @entity2 was performed. Clinical and radiographic characteristics were collected and analyzed. RESULTS Ten @entity0 (19.2%) suffered an @entity3 attributable to a traumatic @entity4 . Univariate analysis demonstrated that @entity0 with @entity3 were significantly older (p = 0.042) and had a lower rate of cervical spine surgery (p < 0.005). Multivariate analysis found cervical spine surgery to be protective against @entity3 (OR 0.049 [95% CI 0.014-0.167], p = 0.014); increasing age and bilateral @entity6 (bilateral occlusion or unilateral occlusion with contralateral dissection) were risk factors for @entity3 (OR 1.05 [95% CI1.02-1.07], p = 0.065 and OR 13.2 [95% CI 2.98-58.9], p = 0.084, respectively). CONCLUSIONS Traumatic @entity4 is associated with a risk of @entity3 and mortality. Corrective cervical spine surgery potentially decreases the risk of @entity3 by stabilizing the spine and thereby reducing motion across the occluded segment of the VA and preventing embolization of @entity5 . While a high stoke risk may be @entity1 , novel therapies should be investigated.

title: Corrective spinal surgery may be protective against stroke in XXXX with blunt traumatic @entity4 .

answer: @entity0


abstract: OBJECTIVE: The development of @entity5 is affected by the presence of cardiovascular risk factors. It is unclear, whether particular risk factors are leading to different clinical stages of @entity5 . The aim of this retrospective cross-sectional study was to assess the association of cardiovascular risk factors with the presence of @entity6 . METHODS: The study cohort was derived from a consecutive registry of @entity0 undergoing endovascular therapy in a tertiary referral centre between January 2000 and April 2014. @entity0 undergoing first-time endovascular intervention for chronic @entity5 of the lower extremities were included. Univariate and multivariate logistic regression models were used to assess the association of age, sex, @entity1 , @entity2 , dyslipidaemia, smoking, and @entity3 with @entity6 vs. @entity4 . RESULTS: A total of 3406 @entity0 were included in the study (mean age 71.7      11.8 years, 2075 [61%] male). There was a significant association of age (OR 1.67, 95%-CI 1.53-1.82, p  <  0.001), male gender (OR 1.23, 95%-CI 1.04-1.47, p  =  0.016), @entity1 (OR 1.99, 95%-CI 1.68-2.36, p  <  0.001) and @entity3 (OR 1.62, 95%-CI 1.35-1.96, p  <  0.001) with the likelihood of @entity6 . Smoking was associated with @entity4 rather than @entity6 (OR 0.78, 95%-CI 0.65-0.94, p  =  0.010), while @entity2 and dyslipidaemia did not show an association with @entity6 . CONCLUSIONS: In @entity5 @entity0 undergoing first-time endovascular treatment, age, male gender, @entity1 , and @entity3 were the strongest predictors for the presence of @entity6 .

title: Impact of cardiovascular risk factors on severity of XXXX .

answer: @entity5


abstract: BACKGROUND: Transfer of the coracoid (Bristow-Latarjet [B-L]) is used to stabilize anterior shoulder instability. We report the long-term results of our first 31 operations with this method. MATERIALS AND METHODS: Thirty-six @entity0 (mean age, 26.7  years) had a B-L repair from 1977 to 1979. Five @entity0 died, and during 2012 to 2013, the remaining 31 shoulders had a follow-up with questionnaire, physical examination, Western Ontario Shoulder Instability Index, Subjective Shoulder Value, Subjective Assessment of Shoulder Function, subjective assessment of loss of motion, and radiologic imaging. RESULTS: One @entity0 required revision surgery because of recurrence and another because of repeat dislocation. Six @entity0 reported subluxations. Eighteen @entity0 (58%) were very satisfied, and 13 (42%) were satisfied. The mean Western Ontario Shoulder Instability Index score (100 possible) was 85, and the median score was 93. According to Samilson-Prieto classification of @entity2 of the shoulder, 39% were classified as normal, 27% as mild, 23% as moderate, and 11% as severe. The classification of @entity2 varied with observers and radiologic views. Age younger than 22  years at the @entity3 meant less @entity2 at follow-up (P  =  .045). CONCLUSION: The degree of @entity2 33 to 35  years after the B-L repair seems to follow the natural history of shoulder dislocation with respect to @entity1 . Postoperative restriction of external rotation does not increase later @entity2 .

title: Risk of XXXX after the Bristow-Latarjet repair: a radiologic and clinical thirty-three to thirty-five years of follow-up of thirty-one shoulders.

answer: @entity2


abstract: High density lipoprotein (HDL) @entity3 and the HDL/total @entity3 ratio have been measured in 440 @entity0 with coronary, cerebral or @entity5 and in 440 matched controls. The @entity0 were subdivided into sex- and age-groups and according to physical activity, smoking, @entity2 and @entity6 . The average HDL @entity3 level was significantly decreased in all the three groups of localization of @entity4 ( @entity4 ). Plasma HDL concentration in @entity0 was lower than in @entity0 in every age-group. Lowest values were measured in @entity0 with @entity4 . From among the risk factors supposed to be related to @entity4 , lack of physical exercise resulted in a decrease of HDL @entity3 and HDL/total @entity3 values. In all the three localizations of @entity4 cigarette smokers had lower HDL levels than non-smokers. The influence of @entity2 on serum HDL concentration was not unidirectional. The coexistence of @entity6 resulted in decreased lipid parameters. The sera of insulin-dependent @entity1 had higher HDL contents and higher HDL/total @entity3 ratios than those of non- @entity1 in all the three localizations of the @entity4 in @entity0 and in @entity0 suffering from @entity5 .

title: Plasma high density lipoproteins in coronary, cerebral and XXXX . The influence of various risk factors.

answer: @entity5


abstract: OBJECTIVES: To investigate the association of carotid @entity1 (CAC) on panoramic radiographs and determine carotid artery @entity2 with ultrasonography. STUDY DESIGN: The study included 4050 subjects aged 50 years and older. Panoramic radiographs for the presence of CAC were interpreted. @entity3 ( @entity3 ), @entity4 ( @entity4 ), carotid plaques, and the diameter of the common carotid artery (CCA-diameter) were measured by using ultrasonography. RESULTS: @entity4 was significantly greater in male subjects with CAC than in those without CAC. CCA-diameter was significantly greater in subjects with CAC than in those without CAC in both genders. However, there was no significant difference in @entity3 . CAC was associated with carotid plaque (for @entity0 , odds ratio [OR] 2.14; 95% confidence interval [CI] 1.01-3.36; for @entity0 , OR 1.19; 95% CI 0.84-1.67). CONCLUSION: CAC on panoramic radiographs was positively associated with IMT and plaque in @entity0 and positively associated with carotid diameter in both sexes. CAC on panoramic radiographs was positively associated with @entity3 .

title: The correlation of carotid XXXX on panoramic radiographs and determination of carotid artery @entity2 with ultrasonography.

answer: @entity1


abstract: OBJECTIVES: To investigate the association of carotid @entity1 (CAC) on panoramic radiographs and determine carotid artery @entity2 with ultrasonography. STUDY DESIGN: The study included 4050 subjects aged 50 years and older. Panoramic radiographs for the presence of CAC were interpreted. @entity3 ( @entity3 ), @entity4 ( @entity4 ), carotid plaques, and the diameter of the common carotid artery (CCA-diameter) were measured by using ultrasonography. RESULTS: @entity4 was significantly greater in male subjects with CAC than in those without CAC. CCA-diameter was significantly greater in subjects with CAC than in those without CAC in both genders. However, there was no significant difference in @entity3 . CAC was associated with carotid plaque (for @entity0 , odds ratio [OR] 2.14; 95% confidence interval [CI] 1.01-3.36; for @entity0 , OR 1.19; 95% CI 0.84-1.67). CONCLUSION: CAC on panoramic radiographs was positively associated with IMT and plaque in @entity0 and positively associated with carotid diameter in both sexes. CAC on panoramic radiographs was positively associated with @entity3 .

title: The correlation of carotid @entity1 on panoramic radiographs and determination of carotid artery XXXX with ultrasonography.

answer: @entity2


abstract: OBJECTIVE: To evaluate the safety and efficacy of @entity2 (NAC) orally on digital microcirculation blood flow in @entity0 with @entity4 ( @entity4 ) secondary to @entity1 ( @entity1 ). METHODS: This was a randomized, double-blind, placebo-controlled trial in which 42 @entity0 with @entity1 received oral NAC at a dose of 600mg tid (21 @entity0 , mean age 45.6  9.5 years) or placebo (21 @entity0 , mean age 45.0  12.7 years) for four weeks. The primary endpoint was the change in cutaneous microcirculation blood flow before and after cold stimulation measured by laser Doppler imaging (LDI) at weeks 0 and 4. The frequency and severity of @entity4 and the number of digital @entity3 were also measured at weeks 0 and 4. The adverse events were recorded in the fourth week. RESULTS: There was no significant change in digital blood flow assessed by LDI before or after cold stimulus after four weeks of NAC or placebo. Both groups showed significant improvement in the frequency and severity of @entity4 attacks, with no difference between the two groups. At the end of the study, the placebo group had three digital @entity3 , while the NAC group showed no @entity3 . NAC was well tolerated and no @entity0 discontinued the treatment. CONCLUSIONS: NAC orally at a dose of 1800mg/day showed no vasodilator effect on hands' microcirculation after four weeks of treatment in @entity0 with @entity4 secondary to @entity1 .

title: [Oral @entity2 in the treatment of XXXX secondary to @entity1 : a randomized, double-blind, placebo-controlled clinical trial].

answer: @entity4


abstract: OBJECTIVE: To evaluate the safety and efficacy of @entity2 (NAC) orally on digital microcirculation blood flow in @entity0 with @entity4 ( @entity4 ) secondary to @entity1 ( @entity1 ). METHODS: This was a randomized, double-blind, placebo-controlled trial in which 42 @entity0 with @entity1 received oral NAC at a dose of 600mg tid (21 @entity0 , mean age 45.6  9.5 years) or placebo (21 @entity0 , mean age 45.0  12.7 years) for four weeks. The primary endpoint was the change in cutaneous microcirculation blood flow before and after cold stimulation measured by laser Doppler imaging (LDI) at weeks 0 and 4. The frequency and severity of @entity4 and the number of digital @entity3 were also measured at weeks 0 and 4. The adverse events were recorded in the fourth week. RESULTS: There was no significant change in digital blood flow assessed by LDI before or after cold stimulus after four weeks of NAC or placebo. Both groups showed significant improvement in the frequency and severity of @entity4 attacks, with no difference between the two groups. At the end of the study, the placebo group had three digital @entity3 , while the NAC group showed no @entity3 . NAC was well tolerated and no @entity0 discontinued the treatment. CONCLUSIONS: NAC orally at a dose of 1800mg/day showed no vasodilator effect on hands' microcirculation after four weeks of treatment in @entity0 with @entity4 secondary to @entity1 .

title: [Oral @entity2 in the treatment of @entity4 secondary to XXXX : a randomized, double-blind, placebo-controlled clinical trial].

answer: @entity1


abstract: OBJECTIVE: To evaluate the safety and efficacy of @entity2 (NAC) orally on digital microcirculation blood flow in @entity0 with @entity4 ( @entity4 ) secondary to @entity1 ( @entity1 ). METHODS: This was a randomized, double-blind, placebo-controlled trial in which 42 @entity0 with @entity1 received oral NAC at a dose of 600mg tid (21 @entity0 , mean age 45.6  9.5 years) or placebo (21 @entity0 , mean age 45.0  12.7 years) for four weeks. The primary endpoint was the change in cutaneous microcirculation blood flow before and after cold stimulation measured by laser Doppler imaging (LDI) at weeks 0 and 4. The frequency and severity of @entity4 and the number of digital @entity3 were also measured at weeks 0 and 4. The adverse events were recorded in the fourth week. RESULTS: There was no significant change in digital blood flow assessed by LDI before or after cold stimulus after four weeks of NAC or placebo. Both groups showed significant improvement in the frequency and severity of @entity4 attacks, with no difference between the two groups. At the end of the study, the placebo group had three digital @entity3 , while the NAC group showed no @entity3 . NAC was well tolerated and no @entity0 discontinued the treatment. CONCLUSIONS: NAC orally at a dose of 1800mg/day showed no vasodilator effect on hands' microcirculation after four weeks of treatment in @entity0 with @entity4 secondary to @entity1 .

title: [Oral XXXX in the treatment of @entity4 secondary to @entity1 : a randomized, double-blind, placebo-controlled clinical trial].

answer: @entity2


abstract: AIM: To investigate the effect of @entity1 repair (EVAR) on platelet (PLT) function and reveal possible associated factors. METHODS: Fifty consecutive @entity0 were included. PLT count and activation ( @entity6 - @entity5 ), white blood cell (WBC) count, and high sensitivity @entity3 (hs-CRP) were measured preoperatively, at the first and third postoperative day. RESULTS: EVAR elicited a significant reduction in PLT count from baseline to first day after EVAR (p   <   0.001), while no significant difference was noted between the first and third day. Furthermore, @entity6 expression was markedly elevated at the first day after EVAR (median % positive PLTs from 13.7 at baseline to 22.1, p   =   0.05), but returned to baseline levels by the third day. Maximum @entity2 diameter was the only factor that significantly affected the @entity6 values (p   =   0.005). Postoperative @entity5 values were significantly correlated with total @entity1 volume (p   =   0.05) and were higher in endografts made from @entity4 (p   =   0.01). There were no correlation between PLT activation and hs-CRP, WBC, maximum temperature, and 30-day morbidity. CONCLUSION: EVAR has elucidated a significant reduction in PLT count and increase in PLT activation at the immediate postoperative period. The type of the endograft material and the @entity1 maximum diameter and volume appear to play an important role in PLT activation.

title: Platelet activation after endovascular repair of XXXX .

answer: @entity2


abstract: INTRODUCTION: Risk scores have been developed for allogeneic hematopoietic cell transplantation (HCT) outcomes, such as the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI) and the modified European Group for Blood and Marrow Transplantation risk score (mEBMT) for @entity2 . We investigated the influence of these scores for 350 @entity0 who underwent transplantation for @entity2 ( @entity2 ). @entity0 AND METHODS: The HCT-CI scores were grouped as 0 to 2 and  >=  3 (231 and 119 @entity0 , respectively) and the mEBMT scores as 0 to 2 and  >=  3 (166 and 184 @entity0 , respectively). RESULTS: Univariate analysis showed a significant association between the HCT-CI score and @entity1 ( @entity1 ) (P  = .01), as did the mEBMT score (P  = .002). The 5-year @entity1 rate was 50% and 34% for a mEBMT score of 0 to 2 and  >=  3, respectively. A subgroup of @entity0 with a mEBMT score of 0 to 1 (n  = 32) demonstrated a favorable @entity1 of 75% at 5 years. This subgroup was younger (median age, 31 years), in first remission at transplantation, and had related donors. For the HCT-CI, the 5-year @entity1 was 46% and 34% for a score of 0 to 2 and  >=  3, respectively. @entity0 with an HCT-CI score of 0 (n  = 94) had a 5-year @entity1 of 44%. Multivariable analysis confirmed both the HCT-CI score and the mEBMT score, as previously grouped, as independent prognostic variables for both @entity1 (P  = .02 and P  = .001, respectively) and nonrelapse mortality (NRM) (P  = .01 and P  = .003, respectively). CONCLUSION: The results of the present study have demonstrated that the HCT-CI and mEBMT are both prognostic for @entity1 and NRM in our cohort. However, the mEBMT score can identify a favorable-risk subgroup of @entity0 not identifiable using the HCT-CI.

title: Modified EBMT Pretransplant Risk Score Can Identify Favorable-risk @entity0 Undergoing Allogeneic Hematopoietic Cell Transplantation for XXXX , Not Identified by the HCT-CI Score.

answer: @entity2


abstract: INTRODUCTION: Risk scores have been developed for allogeneic hematopoietic cell transplantation (HCT) outcomes, such as the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI) and the modified European Group for Blood and Marrow Transplantation risk score (mEBMT) for @entity2 . We investigated the influence of these scores for 350 @entity0 who underwent transplantation for @entity2 ( @entity2 ). @entity0 AND METHODS: The HCT-CI scores were grouped as 0 to 2 and  >=  3 (231 and 119 @entity0 , respectively) and the mEBMT scores as 0 to 2 and  >=  3 (166 and 184 @entity0 , respectively). RESULTS: Univariate analysis showed a significant association between the HCT-CI score and @entity1 ( @entity1 ) (P  = .01), as did the mEBMT score (P  = .002). The 5-year @entity1 rate was 50% and 34% for a mEBMT score of 0 to 2 and  >=  3, respectively. A subgroup of @entity0 with a mEBMT score of 0 to 1 (n  = 32) demonstrated a favorable @entity1 of 75% at 5 years. This subgroup was younger (median age, 31 years), in first remission at transplantation, and had related donors. For the HCT-CI, the 5-year @entity1 was 46% and 34% for a score of 0 to 2 and  >=  3, respectively. @entity0 with an HCT-CI score of 0 (n  = 94) had a 5-year @entity1 of 44%. Multivariable analysis confirmed both the HCT-CI score and the mEBMT score, as previously grouped, as independent prognostic variables for both @entity1 (P  = .02 and P  = .001, respectively) and nonrelapse mortality (NRM) (P  = .01 and P  = .003, respectively). CONCLUSION: The results of the present study have demonstrated that the HCT-CI and mEBMT are both prognostic for @entity1 and NRM in our cohort. However, the mEBMT score can identify a favorable-risk subgroup of @entity0 not identifiable using the HCT-CI.

title: Modified EBMT Pretransplant Risk Score Can Identify Favorable-risk XXXX Undergoing Allogeneic Hematopoietic Cell Transplantation for @entity2 , Not Identified by the HCT-CI Score.

answer: @entity0


abstract: UNASSIGNED: Flooding and drought affect @entity0 growth because @entity0 is a stress-sensitive crop. In 2-day-old plants exposed to 2-day flooding or drought, the fresh weight of roots was markedly suppressed, although the root morphology clearly differed between two conditions. To understand the response mechanisms of @entity0 to flooding and drought stresses, a gel-free proteomic technique was used. A total of 97 and 48 proteins were significantly changed in response to flooding and drought stresses, respectively. Proteins involved in protein synthesis were decreased by flooding stress and increased by drought. Glycolysis-related proteins were increased in roots by both flooding and drought stresses. Fermentation, stress, and cell wall-related proteins were increased in response to flooding stress, whereas cell organization and redox-related proteins were increased under drought stress. Among the identified proteins, three @entity1 synthetases were commonly decreased and increased in response to flooding and drought stresses, respectively. The mRNA expression levels of @entity1 synthetase genes displayed a similar tendency to the changes in protein abundance. These results suggest that @entity1 synthetase is involved in the regulation of stress response because it was changed in response to flooding and drought stresses. BIOLOGICAL SIGNIFICANCE: This study reported on the response mechanisms of @entity0 to flooding and drought stresses using the gel-free proteomic technique. Proteins involved in protein synthesis were decreased by flooding stress and increased by drought. Glycolysis-related proteins were increased in roots by both flooding and drought stresses. Fermentation, stress, and cell wall-related proteins were increased in response to flooding stress, whereas cell organization and redox-related proteins were increased under drought stress. Among the identified proteins, three @entity1 synthetases were commonly decreased and increased in response to flooding and drought stresses, respectively. The mRNA expression levels of @entity1 synthetase genes displayed a similar tendency to the changes in protein abundance. These results suggest that @entity1 synthetase is involved in the regulation of stress response because it was changed in response to flooding and drought stresses.

title: Characterization of proteins in XXXX roots under flooding and drought stresses.

answer: @entity0


abstract: UNASSIGNED: To examine safety and efficacy of bandage soft contact lenses (BSCLs) for ocular chronic @entity1 ( @entity1 ), we conducted a phase II clinical trial. Extended-wear BSCLs were applied under daily topical antibiotic prophylaxis. @entity0 completed standardized symptom questionnaires at enrollment and at 2  weeks, 4  weeks, and 3  months afterward. Ophthalmologic assessment was performed at enrollment, at 2  weeks, and afterward as medically needed. Assessments at follow-up were compared with baseline by paired t-test. Nineteen @entity0 with ocular @entity1 who remained symptomatic despite conventional treatments were studied. The mean Lee eye subscale score was 75.4 at enrollment and improved significantly to 63.2 at 2  weeks (P  =  .01), to 61.8 at 4  weeks (P  =  .005), and to 56.3 at 3  months (P  =  .02). The ocular surface disease index score and 11-point eye symptom ratings also improved significantly. According to the Lee eye subscale, clinically meaningful improvement was observed in 9 @entity0 (47%) at 2  weeks, in 11 @entity0 (58%) at 4  weeks, and in 9 @entity0 (47%) at 3  months. Visual acuity improved significantly at 2  weeks compared with enrollment values. Based on slit lamp exam at 2  weeks, punctate epithelial erosions improved in 58% of the @entity0 , showed stability in 16%, and worsened in 5%. No corneal ulceration or @entity2 occurred. BSCLs are a widely available, safe, and effective treatment option that improves manifestations of ocular @entity1 in approximately 50% of @entity0 . This study was registered at www.clinicaltrials.gov as NCT01616056.

title: Bandage Soft Contact Lenses for Ocular XXXX .

answer: @entity1


abstract: In a retrospective study, the clinical course of 23 adult @entity0 with documented idiopathic @entity1 was reviewed. These @entity0 included 16 @entity0 and 7 @entity0 , who were followed for a period of as long as 9 years, 22 @entity0 (95.7%) were @entity9 ( @entity7 of 3 g or more in 24 h) and 6 (26%) were @entity2 . 5 @entity0 were treated with @entity4 alone, 12 with @entity4 and @entity8 , 2 with @entity4 and @entity6 and 4 received no treatment. 18 @entity0 achieved complete remission (78.3%). 16 of these (88.9%) were treated with @entity4 , or @entity4 and @entity8 or @entity6 , and the remaining remitted spontaneously. In 3 additional @entity0 , @entity7 improved with treatment with @entity4 and immunosuppression but remained in the @entity9 range in 2, and fell to 1.8 g/day in 1. @entity0 who failed to respond to @entity5 showed remarkable improvement when therapy with @entity8 was added. Of the 4 @entity0 not treated, 2 underwent spontaneous remission and 2 developed @entity3 . These results suggest a beneficial effect of @entity5 in the treatment of @entity1 , and suggests further that @entity8 may be effective in @entity0 not responding to @entity5 alone. Finally, these results suggest that in many @entity0 therapy may have to be prolonged before a remission can be observed.

title: XXXX : response to @entity5 and immunosuppression.

answer: @entity1


abstract: In a retrospective study, the clinical course of 23 adult @entity0 with documented idiopathic @entity1 was reviewed. These @entity0 included 16 @entity0 and 7 @entity0 , who were followed for a period of as long as 9 years, 22 @entity0 (95.7%) were @entity9 ( @entity7 of 3 g or more in 24 h) and 6 (26%) were @entity2 . 5 @entity0 were treated with @entity4 alone, 12 with @entity4 and @entity8 , 2 with @entity4 and @entity6 and 4 received no treatment. 18 @entity0 achieved complete remission (78.3%). 16 of these (88.9%) were treated with @entity4 , or @entity4 and @entity8 or @entity6 , and the remaining remitted spontaneously. In 3 additional @entity0 , @entity7 improved with treatment with @entity4 and immunosuppression but remained in the @entity9 range in 2, and fell to 1.8 g/day in 1. @entity0 who failed to respond to @entity5 showed remarkable improvement when therapy with @entity8 was added. Of the 4 @entity0 not treated, 2 underwent spontaneous remission and 2 developed @entity3 . These results suggest a beneficial effect of @entity5 in the treatment of @entity1 , and suggests further that @entity8 may be effective in @entity0 not responding to @entity5 alone. Finally, these results suggest that in many @entity0 therapy may have to be prolonged before a remission can be observed.

title: @entity1 : response to XXXX and immunosuppression.

answer: @entity5


abstract: BACKGROUND: In the recently reported international survey of centers performing per-oral endoscopic myotomy (POEM), 88% of operators reported obtaining routinely an early postoperative contrast esophagram. To date, there have been no studies to assess the prognostic value of early esophagram in POEM. METHODS: A retrospective review of a prospectively maintained, single-institution database of @entity0 who underwent POEM for treatment of @entity2 was conducted. @entity0 were evaluated with a routine contrast esophagram on the first postoperative day ( @entity1 ) to assess for perforation. The finding of delayed esophageal emptying, as determined by an attending radiologist, was compared with the @entity0 ' symptomatic outcomes and functional parameters at one year follow-up. RESULTS: Contrast esophagram was obtained on @entity1 for 72 @entity0 undergoing POEM; 26 @entity0 (36%) were observed to have a delay in esophageal emptying. Both groups of @entity0 , those with a delay and those without a delay in esophageal emptying on @entity1 , had similar preoperative Eckardt scores (7      2 vs 7      2, P = ns) and column height at 5  minutes on preoperative timed barium esophagram (12.1      8  cm vs 14.1      8  cm, P  =  ns). At a mean follow-up of 1  year, there was no difference in Eckardt scores between @entity0 with and those without a delay in emptying on @entity1 esophagram (1      2 vs 1      1, P = ns), nor was there a difference between the 2 groups in column height at 5  minutes on TBE (5.5      5  cm for delay vs 4.2      4  cm for no delay; P = ns). Rates of treatment failure, as measured by Eckardt score >3 or need for subsequent treatment, also did not differ between the 2 groups (3 @entity0 with delay vs 4 @entity0 without delay in emptying, P = ns). CONCLUSION: Delay in passage of contrast on @entity1 esophagram did not predict symptomatic or physiologic outcomes at 1-year follow-up in @entity0 undergoing POEM for treatment of @entity2 .

title: Early esophagram in per-oral endoscopic myotomy (POEM) for XXXX does not predict long-term outcomes.

answer: @entity2


abstract: UNASSIGNED: Current models of @entity3 ( @entity3 ) are @entity2 models of femoral vein terminolaterally anastomosed to femoral artery, creating a deep @entity3 . This feature sets it aside from @entity0 AVFs using superficial veins. Our @entity3 model uses @entity1 superficial veins to create an @entity3 almost identical to @entity0 model. AVFs were created in six @entity1 using basilic veins sutured terminolaterally to brachial artery. Presurgery vein and artery diameters were measured. We measured AVFs and feeding arteries blood flows and diameters at 1, 3, and 5  weeks postsurgery. At 5  weeks we performed angiograms, euthanized animals, and harvested AVFs. Four animals completed the study. Three AVFs developed and were patent at 5  weeks; one thrombosed. Animal weight and presurgery vessels diameters predicted AVFs blood flows and diameters. Despite using vessels with diameters smaller than the ones recommended for @entity0 @entity3 , the Fistulas developed. Two animals died before the study conclusion for causes unrelated to surgery. This @entity3 model is anatomically almost identical to the @entity0 @entity3 and has a good maturation rate. It is a viable model for studying @entity3 maturation, devices intended to improve @entity3 maturation, @entity3 related procedures and can even support hemodialysis needles.

title: XXXX Model of Hemodialysis Arteriovenous Fistula Using Superficial Veins.

answer: @entity1


abstract: BACKGROUND: @entity3 is characterized by @entity2 , senile plaques of b-amyloid (Ab) peptides, neurofibrillary tangles composed of hyperphosphorylated    proteins and @entity4 . Ab and    are useful markers in the cerebrospinal fluid (CSF). C-Jun N-terminal kinases (JNKs) are @entity5 - @entity6 protein kinases activated by phosphorylation and involved in @entity4 . METHODS: In this study, Western blots, enzyme-linked immunosorbent assay and histological approaches were used to assess the concentrations of Ab,    and @entity7 isoforms in postmortem brain tissue samples (10 @entity3 and 10 control) and in CSF samples from 30 living @entity0 with @entity3 and 27 controls with @entity1 excluding @entity3 . @entity0 with @entity3 were followed for 1-3 years and assessed using Mini-Mental State Examination scores. RESULTS: The biochemical and morphological results showed a significant increase of @entity8 and phosphorylated @entity7 levels in @entity0 with @entity3 , and @entity8 levels correlated with Ab42 levels. Confocal microscopy revealed that @entity8 was associated with Ab in senile plaques. The @entity8 levels in the CSF were significantly elevated in @entity0 with @entity3 and correlated statistically with the rate of @entity2 in a mixed linear model. LIMITATIONS: The study involved different samples grouped into 3 small cohorts. Evaluation of @entity8 in CSF was possible only with immunoblot analysis. CONCLUSION: We found that @entity8 levels are increased in brain tissue and CSF from @entity0 with @entity3 . The finding that increased @entity8 levels in CSF could reflect the rate of @entity2 is new and merits further investigation.

title: Increased levels of cerebrospinal fluid XXXX associated with amyloid pathology: links to @entity2 .

answer: @entity8


abstract: BACKGROUND: @entity3 is characterized by @entity2 , senile plaques of b-amyloid (Ab) peptides, neurofibrillary tangles composed of hyperphosphorylated    proteins and @entity4 . Ab and    are useful markers in the cerebrospinal fluid (CSF). C-Jun N-terminal kinases (JNKs) are @entity5 - @entity6 protein kinases activated by phosphorylation and involved in @entity4 . METHODS: In this study, Western blots, enzyme-linked immunosorbent assay and histological approaches were used to assess the concentrations of Ab,    and @entity7 isoforms in postmortem brain tissue samples (10 @entity3 and 10 control) and in CSF samples from 30 living @entity0 with @entity3 and 27 controls with @entity1 excluding @entity3 . @entity0 with @entity3 were followed for 1-3 years and assessed using Mini-Mental State Examination scores. RESULTS: The biochemical and morphological results showed a significant increase of @entity8 and phosphorylated @entity7 levels in @entity0 with @entity3 , and @entity8 levels correlated with Ab42 levels. Confocal microscopy revealed that @entity8 was associated with Ab in senile plaques. The @entity8 levels in the CSF were significantly elevated in @entity0 with @entity3 and correlated statistically with the rate of @entity2 in a mixed linear model. LIMITATIONS: The study involved different samples grouped into 3 small cohorts. Evaluation of @entity8 in CSF was possible only with immunoblot analysis. CONCLUSION: We found that @entity8 levels are increased in brain tissue and CSF from @entity0 with @entity3 . The finding that increased @entity8 levels in CSF could reflect the rate of @entity2 is new and merits further investigation.

title: Increased levels of cerebrospinal fluid @entity8 associated with amyloid pathology: links to XXXX .

answer: @entity2


abstract: Ten @entity0 with unilateral @entity4 had been treated by @entity5 in the years 1971-1979. The proximal part of the facial nerve inside the petrous bone and at the inner ear entrance had been destroyed by @entity1 or accident without chance for repair. Therefore the hypoglossal nerve had been used to contact the intact main tunk and its intact peripheral nerve and mimic muscle system. 3 to 4 epineural nerve sutures had been placed with 8/0 vicryl suture material for approximation. In one @entity0 @entity3 could be obtained by splitting the hypoglossal nerve with remarkable result to the mimic function, while the muscular @entity2 of the tongue was minimal. With regard to the results the achieved mimic reinnervation took place in 3,5 to 5 months, but was found to be refined up to 2 years. Oral discomfort, swallowing, and @entity6 lasted 2 1/2 to 6 weeks postoperatively, depending upon the age and the @entity0 mental activity, since the @entity0 has to learn by using his tongue for mimical expressions. The final result obtained a balanced closure of the mouth and eyes, a complete movement of the lips and cheeks, a rarely delayed innervation of the frontal muscles. Due to reinnervation the denervated half of the tongue had developed a marked increase of activity from nerve fiber ingrowth of the intact side. The @entity0 finally feels little to complain about the favourable facial result.

title: [ XXXX for rehabilitation of the paralyzed face (author's transl)].

answer: @entity5


abstract: UNASSIGNED: To analyze the glycosylation of anti- @entity5 , we investigated purified IgG from healthy @entity0 , @entity0 with @entity6 , and asymptomatic adult carriers of antiphospholipid antibodies. We observed that in the sera of healthy @entity0 and of @entity0 with @entity6 , @entity3 and IgG2 were predominant, respectively. The potentially protective anti- @entity5 -IgM was lower in the sera of healthy children. Although anti- @entity5 -associated @entity4 did not differ between @entity0 and patients with @entity2 , the associated C3c was significantly higher in the sera of healthy @entity0 . This indicates a more efficient clearance of anti- @entity5 immune complexes in the healthy @entity0 . This clearance is not accompanied by @entity1 or coagulatory events. It is likely that the most important pathogenic factor of the anti- @entity5 -IgG is related to the different glycosylation observed in healthy and diseased individuals. We detected a significantly higher sialylation of anti- @entity5 -IgG isolated from the sera of healthy @entity0 and asymptomatic adults when compared with that of @entity0 with clinically apparent @entity2 . Low sialylated IgG reportedly ameliorates @entity1 and @entity1 promotes hyposialylation. Thus, both reactions create a vicious circle that precipitates the pathology of the @entity2 including thrombus-formation. We conclude that the increased sialylation of anti- @entity5 -IgG of sera of healthy individuals limits their pathogenicity.

title: The Pathogenicity of Anti- XXXX -IgG Autoantibodies Depends on Fc Glycosylation.

answer: @entity5


abstract: BACKGROUND AND OBJECTIVES: Although @entity4 is usually associated with ear problems, it may also originate outside the ear. We therefore assessed the clinical characteristics of @entity0 with @entity4 . SUBJECTS AND METHODS: We analyzed 294 @entity0 who presented with @entity4 . We assessed differences in @entity4 between adults and @entity0 , differences in otogenic vs. @entity4 between adults and @entity0 , differences between @entity0 and @entity0 . RESULTS: Of the 294 @entity0 , 208 (70.7%) had @entity4 and 86 (29.3%) had @entity4 . Hearing disturbance and @entity2 were significantly more common in @entity4 , whereas @entity3 , sore throat, and postnasal drip were significantly more common in @entity4 . @entity0 were more likely to have @entity4 than adults. The proportion of @entity0 with @entity4 was significantly higher in adults than in @entity0 (p<0.05). @entity4 was more common in @entity0 , whereas @entity4 was more common in @entity0 . Among @entity0 with @entity4 , @entity1 was significantly more frequent in @entity0 than in @entity0 (p<0.05). CONCLUSIONS: @entity4 was more frequent in @entity0 than in @entity0 and in @entity0 than in adults, whereas @entity4 was more frequent in @entity0 and adults, indicating that types of @entity4 were dependent on age and gender.

title: Clinical Differences in Types of XXXX .

answer: @entity4


abstract: Research suggests that adverse events in childhood, such as childhood physical, @entity3 , confer risk for later sexual assault. Psychological distress, coping strategies, and @entity1 may help explain the path from childhood abuse to revictimization. The present study explored how the use of sex to regulate negative affect (SRNA) operates independently, and in combination with other psychosocial factors to increase college @entity0 's (N=541) risk of experiencing prospective adult sexual assault (ASA). Sequential multiple mediator models in Mplus were used to assess the effect of three different forms of childhood abuse on prospective ASA, both independently and while controlling for other forms of childhood abuse. The indirect effect of adolescent sexual assault (AdolSA), @entity2 , SRNA, and @entity0 ' response to a sex-related vignette was tested using bias-corrected bootstrapping. In the full path model, @entity4 and AdolSA predicted ASA, while childhood physical and @entity3 were directly associated with AdolSA, but not @entity5 . Additionally, @entity2 and @entity0 ' estimate of their likely behavior in a sex-related vignette directly predicted prospective ASA. Results using bootstrapping revealed that a history of childhood abuse predicted prospective ASA via diverse direct and indirect paths, as well as through a similar multiple mediator path. Overall, findings suggest that a combination of affective, coping, and sexual expectancy factors contribute to risk for revictimization in adult survivors of childhood abuse. Future research directions and targets for risk-reduction programming are discussed.

title: Pathways from childhood abuse to prospective revictimization: XXXX , sex to reduce negative affect, and forecasted @entity1 .

answer: @entity2


abstract: Research suggests that adverse events in childhood, such as childhood physical, @entity3 , confer risk for later sexual assault. Psychological distress, coping strategies, and @entity1 may help explain the path from childhood abuse to revictimization. The present study explored how the use of sex to regulate negative affect (SRNA) operates independently, and in combination with other psychosocial factors to increase college @entity0 's (N=541) risk of experiencing prospective adult sexual assault (ASA). Sequential multiple mediator models in Mplus were used to assess the effect of three different forms of childhood abuse on prospective ASA, both independently and while controlling for other forms of childhood abuse. The indirect effect of adolescent sexual assault (AdolSA), @entity2 , SRNA, and @entity0 ' response to a sex-related vignette was tested using bias-corrected bootstrapping. In the full path model, @entity4 and AdolSA predicted ASA, while childhood physical and @entity3 were directly associated with AdolSA, but not @entity5 . Additionally, @entity2 and @entity0 ' estimate of their likely behavior in a sex-related vignette directly predicted prospective ASA. Results using bootstrapping revealed that a history of childhood abuse predicted prospective ASA via diverse direct and indirect paths, as well as through a similar multiple mediator path. Overall, findings suggest that a combination of affective, coping, and sexual expectancy factors contribute to risk for revictimization in adult survivors of childhood abuse. Future research directions and targets for risk-reduction programming are discussed.

title: Pathways from childhood abuse to prospective revictimization: @entity2 , sex to reduce negative affect, and forecasted XXXX .

answer: @entity1


abstract: UNASSIGNED: Cytotoxin K (CytK) produced by @entity2 s.l. has generally been considered to be associated with the @entity3 . Two distinct variants of CytK have been reported: CytK-1 from @entity4 and CytK-2 from @entity2 . In order to determine whether CytK plays a significant role in the @entity0 , the occurrence of cytK genes was assessed among 390 @entity2 isolates with different origins including clinical and @entity3 samples and was found to be 46%. Interestingly, the cytK occurrence was slightly lower in @entity3 and clinical isolates than in environmental samples. Seventy cytK-2 positive strains (including 28 isolates from foodborne outbreaks) were then selected in order to assess their genetic diversity. A genetic dendrogram based on the cytK-2 sequences of these 70 strains and on two cytK-1 sequences from strains NVH 391-98 and 883-00 showed an important diversity. However, no strain clustering according to the origin or source of isolation was observed. These observations were confirmed by Multi-Locus Sequences Typing (MLST) based on five different loci of housekeeping genes (ccpA, recF, sucC, purF and gdpD) for which no grouping of foodborne outbreak strains could be identified. Therefore, the choice of cytK as virulence factor for the diarrhoeal pathotype does not seem to be relevant per se, even though the involvement of CytK in the @entity1 cannot be fully excluded. Potential synergistic effects between CytK and other virulence factors, together with their potential variable expression levels should be further investigated.

title: Is Cytotoxin K from XXXX a bona fide enterotoxin?

answer: @entity2


abstract: BACKGROUND: The epidemiology of @entity1 ( @entity1 ) in the U.S.A. has been described largely via US population-based questionnaire studies. However, the validity of the questions used for self- and caregiver-reported @entity2 has not been previously demonstrated. OBJECTIVES: To validate the assessment of self- and caregiver-reported @entity2 . METHODS: We performed a prospective multicentre dermatology-practice-based study (three sites) to determine the validity of caregiver- and self-reported ever having @entity2 and 1-year history of @entity2 . Questionnaires were administered to unselected @entity0 prior to their encounter. @entity0 (n = 782) were then evaluated by expert dermatologists trained in utilizing the Hanifin and Rajka criteria for @entity1 . Sensitivity, specificity, positive predictive value ( @entity3 ) and negative predictive value were determined. RESULTS: Caregiver-reported 1-year history of childhood @entity2 was found to have a sensitivity (95% confidence interval) of 0  70 (0  59-0  80), specificity of 0  96 (0  93-0  99) and @entity3 of 0  87 (0  78-0  96) when compared with a physician's diagnosis of @entity1 at that visit. Similarly, self-reported 1-year history of adult @entity2 was found to have a sensitivity of 0  70 (0  59-0  80), specificity of 0  95 (0  93-0  97) and @entity3 of 0  76 (0  64-0  85). The specificities and PPVs of a history of ever having caregiver- (0  89, 0  82-0  96 and 0  81, 0  70-0  93) and self-reported @entity2 (0  97, 0  95-0  99 and 0  91, 0  85-0  97) were high, with a high sensitivity in @entity0 (0  83, 0  72-0  95) but not in adults (0  43, 0  37-0  51). CONCLUSIONS: Self- and caregiver-reported diagnosis of @entity2 ever or in the past year based on a single question demonstrates sufficient validity for the epidemiological study of @entity1 .

title: Assessment of XXXX using self-report and caregiver report: a multicentre validation study.

answer: @entity1


abstract: PURPOSE: To investigate the clinical feasibility and treatment outcomes of image-based @entity3 ( @entity3 ) brachytherapy using an intracavitary multichannel vaginal cylinder for the definitive treatment of @entity1 . METHODS AND MATERIALS: A total of 41 @entity0 with @entity1 (24% primary vaginal and 76% recurrence from other gynecologic primaries) treated with definitive radiotherapy    chemotherapy including image-based @entity3 brachytherapy with a multichannel vaginal cylinder were included in the study. Image-based brachytherapy was completed using either CT- (41%) or MR-based planning (59%) with each fraction. The high-risk clinical target volume was defined based on the pre- and postexternal beam radiotherapy gross @entity1 volume. Doses were converted to equivalent dose of 2Gy per fraction. Endpoints examined were dose-volume parameters and early clinical outcomes. RESULTS: The median high-risk clinical target volume was 24.2cc (interquartile range [IQR], 12.6), with a median dose to 90% (D90) of 77.1Gy (IQR, 3.4). The median dose to 2cc (D2 cc) for the bladder, rectum, and sigmoid were 59.4Gy (IQR, 5.6), 58.2Gy (IQR, 4.1), and 52.3Gy (IQR, 5.5), respectively. After a median followup of 16 months (range, 3-35), complete clinical response was documented in 98% of the @entity0 . The 2-year local, regional, and distant control; and disease-free and overall survival were 93%, 100%, 81%, 78%, and 88%, respectively. The 2-year actuarial rate of late Grade 3 or higher @entity2 was 4% overall with 0%, 0%, 0%, and 4% for vaginal, bladder, urethral, and gastrointestinal, respectively. CONCLUSIONS: Image-based @entity3 brachytherapy using an intracavitary multichannel cylinder seems feasible in @entity1 treatment. The described clinical implementation shows promising early clinical outcomes with high rates of local control and @entity2 , which should be validated with extended followup.

title: Image-based multichannel vaginal cylinder brachytherapy for XXXX .

answer: @entity1


abstract: BACKGROUND: The prevalence of @entity1 in the United States continues to increase. Attention has recently turned to an emerging population of extremely overweight @entity0 , termed superobese and defined as those with body mass index (BMI) >= 50  kg/m(2). The goal of this study was to use a national database to evaluate postoperative complication rates after @entity4 ( @entity4 ) in superobese @entity0 and to compare @entity0 of different BMI classes. METHODS: @entity0 who underwent @entity4 or reverse @entity4 were identified in the PearlDiver database by International Classification of Diseases, Ninth Revision (ICD-9) codes. These @entity0 were then divided into nonobese, @entity1 , and superobese cohorts by ICD-9 codes. @entity2 were assessed and compared between cohorts. RESULTS: From 2005 to 2012, 144,239 unique @entity0 who underwent @entity4 or reverse @entity4 were identified, including 105,661 nonobese @entity0 , 23,864 @entity1 @entity0 , 13,759 morbidly @entity1 @entity0 , and 955 superobese @entity0 . Superobese @entity0 had a significantly higher rate of @entity3 , dislocation, component loosening, revision shoulder arthroplasty, @entity5 , and medical complications after shoulder arthroplasty compared with nonobese controls. CONCLUSIONS: Obesity is associated with significantly increased rates of numerous complications after @entity4 , including @entity3 , dislocation, component loosening, revision surgery, @entity5 , and medical complications, compared with nonobese controls. Superobesity (BMI  > 50  kg/m(2)) is associated with significantly increased rates of several complications compared with even @entity1 and morbidly @entity1 @entity0 , including @entity5 , and medical complications.

title: Superobesity (body mass index >50  kg/m(2)) and  complications after XXXX : an incremental effect of increasing  body mass index.

answer: @entity4


abstract: BACKGROUND: Despite oversized latissimus dorsi free flap reconstruction in the head and neck area, esthetic and functional problems continue to exist due to the well-known occurrence of transplant shrinkage. The purpose of this study was to acquire an estimation of the volume and time of the shrinkage process. MATERIALS AND METHODS: The assessment of @entity1 was performed using a 3D evaluation of two postoperative CT scans. A retrospective review was conducted on all latissimus dorsi free flap reconstructions performed between 2004 and 2013. Inclusion criteria for the assessment were: resection of an @entity2 and microsurgical defect coverage with latissimus dorsi free flap; a first postoperative CT ( @entity3 ) performed between 3 weeks and a maximum of 3 months after reconstruction surgery; and an additional CT scan ( @entity4 ) performed at least one year postoperatively. The exclusion criterion was surgical intervention in the local area between the acquisition of @entity3 and @entity4 . The effect of adjuvant radiation therapy was considered. Volume determination of the transplant was carried out in @entity3 and @entity4 by manual segmentation of the graft. RESULTS: Fifteen @entity0 were recruited. 3D evaluation showed an average @entity1 of 34.4%. In the consideration of postoperative radiotherapy the volume reduction was 39.2% in @entity0 with radiotherapy and 31.3% in @entity0 without radiotherapy. CONCLUSION: The reconstruction flap volume required for overcorrection of the surgical defect was investigated. This study indicates that a @entity1 of more than 30% could be expected one or more years after latissimus dorsi free flap reconstruction. Clinical trial number DRKS00007534.

title: Microvascular transplants in head and neck reconstruction: 3D evaluation of XXXX .

answer: @entity1


abstract: STUDY OBJECTIVE: To evaluate the degree of @entity2 relief provided by laparoscopic surgical treatment of @entity1 . DESIGN: Retrospective analysis DESIGN: Classification: II-2 SETTING: Academic Hospital and affiliated outpatient offices @entity0 : A total of 54 @entity0 from 2004 to 2008 who underwent surgical treatment for suspected @entity1 or @entity1 . INTERVENTION: Oophorectomy MEASUREMENTS AND MAIN RESULTS: Preoperative and @entity3 scores were recorded from @entity0 who underwent surgical treatment for either @entity1 . Data regarding co-morbid diagnoses that would contribute to chronic @entity2 (CPP), previous surgical history, surgical complications and pathology to confirm the preoperative diagnosis were also collected. Pathology confirmed that ovarian tissue was removed in 52 of the 54 @entity0 . 40% and 41% of @entity0 with @entity1 , respectively, achieved a 50% reduction of their average @entity2 levels; 50% and 56%, respectively, achieved a 30% reduction in average @entity2 levels. There was not a statistically significant difference in @entity3 relief between the two groups. Cases with @entity1 had more prior surgical procedures (4.8 vs. 3.6, p=.049) and were more likely to have a surgical complication (25% vs. 3%, p=.03) than cases with @entity1 . @entity0 with a 30% or greater decrease in their @entity2 levels postoperatively were likely to have fewer other diagnoses associated with @entity4 (1.4 + 1.1 vs. 2.1 + 0.9; p=.009). CONCLUSION: Surgical treatment for @entity1 is effective, but is most effective in @entity0 with no other @entity2 -related diagnoses. Thus it is important to thoroughly evaluate @entity0 with @entity1 for other @entity5 . In almost all cases surgery can be done laparoscopically in @entity0 with these syndromes.

title: The Efficacy of Laparoscopic Surgical Treatment of Ovarian XXXX .

answer: @entity1


abstract: INTRODUCTION: @entity5 associated with @entity6 are rare. Most reported cases of @entity11 abscesses occur after chemotherapy and are related to the immunosuppressive effects of the chemotherapy. Their etiology is most frequently fungal. PRESENTATION OF CASE: A 58-year-old male presented with @entity2 and @entity1 secondary to a multibacterial @entity5 which required a splenectomy. Upon investigation he was found to suffer from @entity7 ( @entity7 ) and @entity10 . DISCUSSION: @entity5 are rarely found in @entity6 @entity0 . Reported cases are fungal and commonly occur after chemotherapy due to immunosuppression. @entity1 with concurrent @entity2 can be found in other pathologies including @entity9 , @entity8 and even non-Hodgkin primary @entity4 . @entity1 in our case was likely secondary to @entity10 and exacerbated by the effects of @entity2 upon the systemic circulation promoting @entity3 . CONCLUSION: This case illustrated an unusual presentation of @entity7 because the @entity0 presented with @entity2 , a multibacterial @entity5 , and @entity1 .

title: Case report of rare chronic myelogenous leukemia related multibacterial XXXX presenting with @entity1 .

answer: @entity5


abstract: INTRODUCTION: @entity5 associated with @entity6 are rare. Most reported cases of @entity11 abscesses occur after chemotherapy and are related to the immunosuppressive effects of the chemotherapy. Their etiology is most frequently fungal. PRESENTATION OF CASE: A 58-year-old male presented with @entity2 and @entity1 secondary to a multibacterial @entity5 which required a splenectomy. Upon investigation he was found to suffer from @entity7 ( @entity7 ) and @entity10 . DISCUSSION: @entity5 are rarely found in @entity6 @entity0 . Reported cases are fungal and commonly occur after chemotherapy due to immunosuppression. @entity1 with concurrent @entity2 can be found in other pathologies including @entity9 , @entity8 and even non-Hodgkin primary @entity4 . @entity1 in our case was likely secondary to @entity10 and exacerbated by the effects of @entity2 upon the systemic circulation promoting @entity3 . CONCLUSION: This case illustrated an unusual presentation of @entity7 because the @entity0 presented with @entity2 , a multibacterial @entity5 , and @entity1 .

title: Case report of rare chronic myelogenous leukemia related multibacterial @entity5 presenting with XXXX .

answer: @entity1


abstract: BACKGROUND: More than two fifths of the world's population cook with solid fuels and are exposed to household air pollution (HAP). As of now, no studies have assessed whether switching to alternative fuels like biogas could impact cardiovascular health among cooks previously exposed to solid fuel use. METHODS: We conducted a propensity score matched cross-sectional study to explore if the sustained use of biogas fuel for at least ten years impacts blood pressure among adult female cooks of rural Nepal. We recruited one primary cook >= 30 years of age from each biogas (219 cooks) and firewood (300 cooks) using household and measured their systolic ( @entity4 ) and diastolic blood pressure (DBP). Household characteristics, kitchen ventilation and 24-h kitchen @entity3 were assessed. We matched cooks by age, body mass index and socio-economic status score using propensity scores and investigated the effect of biogas use through multivariate regression models in two age groups, 30-50 years and >50 years to account for any post-menopausal changes. RESULTS: We found substantially reduced 24-h kitchen @entity3 levels among biogas-using households. After matching and adjustment for smoking, kitchen characteristics, ventilation status and additional fuel use, the use of biogas was associated with 9.8mmHg lower @entity4 [95% confidence interval (CI), -20.4 to 0.8] and 6.5mmHg lower DBP (95% CI, -12.2 to -0.8) compared to firewood users among @entity0 >50 years of age. In this age group, biogas use was also associated with 68% reduced odds [Odds ratio 0.32 (95% CI, 0.14 to 0.71)] of developing @entity2 . These effects, however, were not identified in younger @entity0 aged 30-50 years. CONCLUSIONS: Sustained use of biogas for cooking may protect against @entity1 by lowering the risk of @entity2 , especially DBP, among older female cooks. These findings need to be confirmed in longitudinal or experimental studies.

title: Sustained use of biogas fuel and blood pressure among XXXX in rural Nepal.

answer: @entity0


abstract: The anaerobic biotransformation of @entity2 ( @entity3 ) can be affected by competing electron acceptors such as @entity0 . This study assessed the role of @entity0 reduction on the bioenhanced dissolution of @entity3 dense non-aqueous phase liquid (DNAPL). Columns were set up as 1-D diffusion cells consisting of a lower DNAPL layer, a layer with an aquifer substratum and an upper water layer that is regularly refreshed. The substrata used were either inert sand or sand coated with 2-line @entity8 (HFO) or two environmental @entity0 containing samples. The columns were inoculated with @entity7 and were repeatedly fed with @entity4 . In none of the diffusion cells, @entity5 or @entity1 was detected while dissolved and extractable @entity6 increased strongly during 60d of incubation. The cis-DCE concentration peaked at 4.0cm from the DNAPL (inert sand) while it was at 3.4cm (sand+HFO), 1.7cm and 2.5cm (environmental samples). The @entity3 concentration gradients near the DNAPL indicate that the DNAPL dissolution rate was larger than that in an abiotic cell by factors 1.3 (inert sand), 1.0 (sand+HFO) and 2.2 (both environmental samples). This results show that high bioavailable @entity0 in HFO reduces the @entity3 degradation by competitive @entity0 reduction, yielding lower bioenhanced dissolution. However, @entity0 reduction in environmental samples was not reducing @entity3 degradation and the dissolution factor was even larger than that of inert sand. It is speculated that physical factors, e.g. micro-niches in the environmental samples protect microorganisms from toxic concentrations of @entity3 .

title: Bioenhanced dissolution of dense non-aqueous phase of XXXX as affected by iron reducing conditions: Model systems and environmental samples.

answer: @entity2


abstract: Large @entity3 emissions were observed from intertidal sediments in a coastal estuary, @entity0 Harbor, MA, USA. Average @entity3 emission rates from 41 chambers during summer 2008 were 10.7mol N2Om(-2)h(-1)  4.43 mol N2Om(-2)h(-1) (standard error). Emissions were highest from sediments within a known wastewater plume, where a maximum @entity3 emission rate was 155 mol N2Om(-2)h(-1). Intertidal @entity3 fluxes were positively related to porewater ammonium concentrations at 10 and 25cm depths. In groundwater from 7 shoreline wells, dissolved @entity3 ranged from 488% of saturation (56nM @entity3 ) to more than 13000% of saturation (1529nM @entity3 ) and was positively related to @entity1 concentrations. Fresh and brackish porewater underlying 14 chambers was also supersaturated in @entity3 , ranging from 2980% to 13175% of saturation. These observations support a relationship between anthropogenic nutrient loading and @entity3 emissions in @entity0 Harbor, with both groundwater sources and also local @entity3 production within nutrient-rich, intertidal sediments in the groundwater seepage face. @entity3 emissions from intertidal "hotspot" in this harbor, together with estimated surface water emissions, constituted 2.4% of the average overall rate of @entity2 export from the watershed to the estuary. This suggests that @entity3 emissions factors from coastal ecosystems may be underestimated. Since anthropogenic nutrient loading affects estuaries worldwide, quantification of @entity3 dynamics is warranted in other anthropogenically-impacted coastal ecosystems.

title: Substantial nitrous oxide emissions from intertidal sediments and groundwater in anthropogenically-impacted XXXX Harbor, Massachusetts.

answer: @entity0


abstract: BACKGROUND: While current theories on perception of interoceptive signals suggest impaired interoceptive processing in @entity1 such as @entity3 or @entity2 , heart-rate (HR) interoceptive accuracy (IAc) of @entity3 @entity0 under resting conditions is superior to that of healthy controls. Thus, in this study, we chose to assess further physiological parameters and comorbid @entity2 in order to get information on how these potentially conflicting findings are linked together. DESIGN: We used a quasi-experimental laboratory design which included multi-parametric physiological data collection of 40 @entity3 subjects and 53 matched no- @entity3 controls, as well as experimental induction of stress and relaxation over a time-course. METHODS: Stress reactivity, interoceptive awareness (IAw; from the Body Perception Questionnaire (BPQ)) and IAc (as correlation between self-estimation and physiological data) were major outcome variables. Self-estimation of bioparametrical change was measured via numeric rating scales. RESULT: Panic subjects had stronger HR-reaction and more accurate HR-interoception. Concurrently, though, their IAc of skin conductance level, pulse amplitude and breathing amplitude was significantly lower than that of the control group. Interestingly, comorbid @entity2 was found to be associated with increased IAw but attenuated IAc. LIMITATIONS: Demand characteristics and a categorical approach to @entity3 confine the results. CONCLUSION: The potentially conflicting findings coalesce, as @entity3 was associated with an increase of the ability to perceive the fear-related parameter and a simultaneous decrease of the ability to perceive other parameters. The superordinate integration of afferent signals might be impaired.

title: XXXX and their associations with stress reactivity, interoceptive awareness and interoceptive accuracy of various bioparameters.

answer: @entity2


abstract: OBJECTIVE: The aim of this study was to confirm a causal relationship between removal of @entity2 ( @entity2 ) and lower-extremity @entity3 after systematic lymphadenectomy in @entity0 with uterine @entity1 . METHODS: A retrospective chart review was carried out for all @entity0 with uterine corpus malignant @entity1 managed at Hokkaido Cancer Center between 1991 and 2013. All 318 @entity0 underwent @entity2 dissection as a part of initial surgery and 217 @entity0 did not. @entity0 had undergone hysterectomy, bilateral salpingo-oophorectomy and lymphadenectomy and their medical records were reviewed. The type of lymphadenectomy gradually shifted from pelvic lymphadenectomy with @entity2 to full lymphadenectomy without @entity2 dissection during this period. We identified @entity0 with postoperative lower-extremity @entity3 (POLEL). Logistic regression analysis was used to select the risk factors for POLEL. RESULTS: Of 535 @entity0 evaluated, POLEL was noted in the medical records of 126 @entity0 (23.6%), with median follow-up of 71months. The occurrence of POLEL was significantly higher in the @entity2 -dissection group than in the @entity2 -sparing group (34.3% vs. 7.8%, P<0.0001). Multivariate analysis confirmed that adjuvant radiation therapy [odds ratio (OR)=6.3, 95% confidence interval (CI)=2.6-14.9], resection of more than 31 lymph nodes (OR=2.0, 95% CI=1.2-3.5), and @entity2 (OR=5.4, 95% CI=3.1-9.3) were independent risk factors for POLEL. CONCLUSIONS: Elimination of @entity2 dissection can be helpful in reducing the incidence of POLEL.

title: Close relationship between removal of circumflex iliac nodes to distal external iliac nodes and postoperative lower-extremity XXXX in uterine corpus malignant @entity1 .

answer: @entity3


abstract: OBJECTIVE: The aim of this study was to confirm a causal relationship between removal of @entity2 ( @entity2 ) and lower-extremity @entity3 after systematic lymphadenectomy in @entity0 with uterine @entity1 . METHODS: A retrospective chart review was carried out for all @entity0 with uterine corpus malignant @entity1 managed at Hokkaido Cancer Center between 1991 and 2013. All 318 @entity0 underwent @entity2 dissection as a part of initial surgery and 217 @entity0 did not. @entity0 had undergone hysterectomy, bilateral salpingo-oophorectomy and lymphadenectomy and their medical records were reviewed. The type of lymphadenectomy gradually shifted from pelvic lymphadenectomy with @entity2 to full lymphadenectomy without @entity2 dissection during this period. We identified @entity0 with postoperative lower-extremity @entity3 (POLEL). Logistic regression analysis was used to select the risk factors for POLEL. RESULTS: Of 535 @entity0 evaluated, POLEL was noted in the medical records of 126 @entity0 (23.6%), with median follow-up of 71months. The occurrence of POLEL was significantly higher in the @entity2 -dissection group than in the @entity2 -sparing group (34.3% vs. 7.8%, P<0.0001). Multivariate analysis confirmed that adjuvant radiation therapy [odds ratio (OR)=6.3, 95% confidence interval (CI)=2.6-14.9], resection of more than 31 lymph nodes (OR=2.0, 95% CI=1.2-3.5), and @entity2 (OR=5.4, 95% CI=3.1-9.3) were independent risk factors for POLEL. CONCLUSIONS: Elimination of @entity2 dissection can be helpful in reducing the incidence of POLEL.

title: Close relationship between removal of circumflex iliac nodes to distal external iliac nodes and postoperative lower-extremity @entity3 in uterine corpus malignant XXXX .

answer: @entity1


abstract: @entity0 with mesial @entity7 (mTLE) frequently show @entity2 . However, the relation between mTLE and @entity2 is poorly understood. To gain more insight into @entity6 -associated alterations in cognitive performance, we studied the spatial learning of C57BL/6J @entity1 five weeks after @entity8 -induced @entity5 ( @entity5 ). Typically, structural hippocampal rearrangements take place within five weeks after @entity5 . @entity1 were monitored by exposing them to four tasks with a focus on spatial memory and @entity4 : the circular hole board, modified hole board, novel object-placement task, and elevated plus maze. On the circular hole board, animals showed a higher preference for hippocampus-independent strategies after @entity5 . In contrast, no change in strategy was seen on the modified hole board, but animals with @entity5 were able to finish the task more often. Animals did not have an increased preference for a relocated object in the novel object-placement task but showed an increased locomotion after @entity5 . No indications for altered @entity4 were found when tested on the elevated plus maze following @entity5 . These data suggest that the circular hole board is a well-suited paradigm to detect subtle @entity5 -induced @entity3 .

title: XXXX -induced epileptogenesis alters circular hole board learning strategy but not the performance of C57BL/6J @entity1 .

answer: @entity8


abstract: @entity0 with mesial @entity7 (mTLE) frequently show @entity2 . However, the relation between mTLE and @entity2 is poorly understood. To gain more insight into @entity6 -associated alterations in cognitive performance, we studied the spatial learning of C57BL/6J @entity1 five weeks after @entity8 -induced @entity5 ( @entity5 ). Typically, structural hippocampal rearrangements take place within five weeks after @entity5 . @entity1 were monitored by exposing them to four tasks with a focus on spatial memory and @entity4 : the circular hole board, modified hole board, novel object-placement task, and elevated plus maze. On the circular hole board, animals showed a higher preference for hippocampus-independent strategies after @entity5 . In contrast, no change in strategy was seen on the modified hole board, but animals with @entity5 were able to finish the task more often. Animals did not have an increased preference for a relocated object in the novel object-placement task but showed an increased locomotion after @entity5 . No indications for altered @entity4 were found when tested on the elevated plus maze following @entity5 . These data suggest that the circular hole board is a well-suited paradigm to detect subtle @entity5 -induced @entity3 .

title: @entity8 -induced epileptogenesis alters circular hole board learning strategy but not the performance of C57BL/6J XXXX .

answer: @entity1


abstract: BACKGROUND: Prefrontal cortical dysfunction is frequently reported in @entity1 and is thought to underlie negative symptoms of @entity1 . Repetitive Transcranial Magnetic Stimulation (rTMS) can modulate neuronal activity and has been shown to improve negative symptoms in @entity0 with @entity1 , but the underlying neural mechanism is unknown. OBJECTIVE: To examine whether 3weeks of 10Hz rTMS treatment of the bilateral dorsolateral prefrontal cortex (DLPFC) would improve frontal brain activation in @entity0 with negative symptoms of @entity1 , as measured by functional magnetic resonance imaging (fMRI) during the Tower of London (ToL) task. METHODS: 24 @entity0 with the diagnosis of @entity1 with moderate to severe negative symptoms (Positive and Negative Syndrome Scale (PANSS) negative subscale>= 15) participated. @entity0 were randomized to a 3-week (15day) course of active or sham rTMS. All @entity0 performed the ToL task during fMRI scanning both pre-treatment and post-treatment. Differences in brain activation between the two groups were compared non-parametrically. RESULTS: After rTMS treatment, brain activity in the active group increased in the right DLPFC and the right medial frontal gyrus as compared to the sham group. In addition, the groups significantly differed with regard to activation change in the left posterior cingulate, with decreased activation in the active and increased activation in the sham group. CONCLUSIONS: Treatment with rTMS over the DLPFC may have the potential for increasing task-related activation in frontal areas in @entity0 with @entity1 . Effects of different rTMS parameters and fMRI tasks targeting relevant brain circuitry deserve further investigation. TRIAL REGISTRATION: Nederlands Trial Register, registration number: NTR1261.

title: Effect of rTMS on brain activation in XXXX with negative symptoms: A proof-of-principle study.

answer: @entity1


abstract: The @entity1 of a loved one is often an ordeal and a tragedy for those who witness it, as @entity1 is not merely the end of a life, but also the end of an existence, the loss of a unique individual who is special and irreplaceable. In some situations, end-of-life signs, such as agonal gasps, can be an almost unbearable "sight" because the physical manifestations are hard to watch and can lead to subjective interpretation and irrational fears. Ethical unease arises as the dying @entity0 falls prey to @entity1 throes and to the manifestations of ebbing life and the physician can only stand by and watch. From this point on, medicine can put an end to suffering by the use of @entity3 , but in so doing life ceases at the same time. It is difficult, however, not to respond to the distress of loved ones and caregivers. The ethical problem then becomes the shift from the original ethical concern, i.e. the dying @entity0 , to the @entity0 's loved ones. Is such a @entity2 due to a difference in nature or a difference in degree, given that the dying @entity0 remains a @entity0 and not a thing as long as the body continues to lead its own life, expressed through movement and sound? Because there cannot be any simple and unequivocal answer to this question, the SRLF Ethics Commission is offering ethical reflections on end-of-life signs and symptoms in the intensive care setting, and on the use of @entity3 in this context, with presentations on the subject by two philosophers and members of the SRLF Ethics Commission, Ms Lise Haddad and Prof Dominique Folscheid. The SRLF Ethics Commission hopes to provide food for thought for everyone on this topic, which undoubtedly calls for further contributions, the aim being not to provide ready-made solutions or policy, but rather to allow everyone to ponder this question in all conscience.

title: Ethical reflections on end-of-life signs and symptoms in the intensive care setting: a place for XXXX ?

answer: @entity3


abstract: BACKGROUND: A randomized trial demonstrated that a high-dose inactivated @entity1 vaccine (IIV- @entity2 ) was 24.2% more efficacious than a standard-dose vaccine (IIV-SD) against laboratory-confirmed @entity1 in adults >= 65 years. To evaluate the consistency of IIV- @entity2 benefits, supplemental analyses explored efficacy and immunogenicity by baseline characteristics of special interest. METHODS: Double-blind, randomized, active-controlled, multicenter trial. Adults >= 65 years were randomized 1:1 to receive IIV- @entity2 or IIV-SD and followed for 6-8 months postvaccination for the occurrence of @entity1 . One third of @entity0 were randomly selected to provide sera for measurement of hemagglutination inhibition antibody (HAI) titers. Efficacy (IIV- @entity2 vs. IIV-SD) against laboratory-confirmed, protocol-defined @entity1 (PD-ILI) and HAI geometric mean titer (GMT) ratios (IIV- @entity2 /IIV-SD) were evaluated by age, and number of high-risk comorbid and frailty conditions. RESULTS: Efficacy (95% confidence intervals) of IIV- @entity2 relative to IIV-SD against laboratory-confirmed PD-ILI was 19.7% (0.4%; 35.4%) for @entity0 65-74 years, 32.4% (8.1%; 50.6%) for those >= 75 years, 22.1% (3.9%; 37.0%) for @entity0 with >= 1 high-risk comorbidity, 23.6% (-3.2%; 43.6%) for those with >= 2 high-risk comorbidities, 27.5% (0.4%; 47.4%) for @entity0 with 1 frailty condition, 23.9% (-9.0%; 47.2%) for those with 2 frailty conditions, and 16.0% (-16.3%; 39.4%) for those with >= 3 frailty conditions. There was no evidence of vaccine efficacy heterogeneity within age, comorbidity, and frailty strata (P-values 0.351, 0.875, and 0.838, respectively). HAI GMT ratios were significantly higher among IIV- @entity2 recipients for all strains and across all subgroups. CONCLUSIONS: Estimates of relative efficacy consistently favored IIV- @entity2 over IIV-SD. There was no significant evidence that baseline age, comorbidity, or frailty modified the efficacy of IIV- @entity2 relative to IIV-SD. IIV- @entity2 significantly improved HAI responses for all strains and in all subgroups. IIV- @entity2 is likely to provide benefits beyond IIV-SD for adults >= 65 years, irrespective of age and presence of comorbid or frailty conditions.

title: Efficacy and immunogenicity of high-dose XXXX vaccine in older adults by age, comorbidities, and frailty.

answer: @entity1


abstract: PURPOSE: The aim of this study is to investigate efficacy and @entity2 of 1year of @entity4 metronomic therapy preceded by standard adjuvant chemotherapy in @entity0 ( @entity0 ) @entity1 . METHODS: Between June 2010 and February 2012, 19 @entity1 with pathologically proven operable @entity0 , who had received standard adjuvant chemotherapy before were enrolled. @entity1 received 1year of oral @entity4 metronomic therapy (650mg/m(2), twice every day), after standard adjuvant chemotherapy and radiotherapy if indicated. The primary endpoints of this study were disease-free survival rates (DFS) and safety profile. Secondary end point was overall survival (OS). RESULTS: The maximal follow-up was 46.6months with a median of 30.1months   11.525 (95% CI; 28.5-33.5months). The median DFS was 41.7months   2.7 (95% CI; 36.5-46.9). No one developed locoregional recurrence. The actuarial rate of DFS was 88.8% and 82.05% at 2 and 3years, respectively. At the time of the analyses, no @entity1 had died and the median OS was not reached. Treatment-related adverse events were manageable with only 1 @entity1 (5.3%) suffering from Grade 3/4 hand-foot syndrome and another 1 @entity1 (5.3%) suffering from Grade 3 @entity3 . No Grade 3/4 hematologic @entity2 was recorded. All @entity1 received full doses of @entity4 throughout the study and dose reduction was not required in any of our @entity1 . CONCLUSION: One year of @entity4 metronomic therapy preceded by standard adjuvant chemotherapy, is active and well-tolerated in @entity0 @entity1 previously treated with standard adjuvant chemotherapy.

title: Preliminary results of @entity4 metronomic chemotherapy in operable XXXX after standard adjuvant therapy - A single-arm phase II study.

answer: @entity0


abstract: PURPOSE: The aim of this study is to investigate efficacy and @entity2 of 1year of @entity4 metronomic therapy preceded by standard adjuvant chemotherapy in @entity0 ( @entity0 ) @entity1 . METHODS: Between June 2010 and February 2012, 19 @entity1 with pathologically proven operable @entity0 , who had received standard adjuvant chemotherapy before were enrolled. @entity1 received 1year of oral @entity4 metronomic therapy (650mg/m(2), twice every day), after standard adjuvant chemotherapy and radiotherapy if indicated. The primary endpoints of this study were disease-free survival rates (DFS) and safety profile. Secondary end point was overall survival (OS). RESULTS: The maximal follow-up was 46.6months with a median of 30.1months   11.525 (95% CI; 28.5-33.5months). The median DFS was 41.7months   2.7 (95% CI; 36.5-46.9). No one developed locoregional recurrence. The actuarial rate of DFS was 88.8% and 82.05% at 2 and 3years, respectively. At the time of the analyses, no @entity1 had died and the median OS was not reached. Treatment-related adverse events were manageable with only 1 @entity1 (5.3%) suffering from Grade 3/4 hand-foot syndrome and another 1 @entity1 (5.3%) suffering from Grade 3 @entity3 . No Grade 3/4 hematologic @entity2 was recorded. All @entity1 received full doses of @entity4 throughout the study and dose reduction was not required in any of our @entity1 . CONCLUSION: One year of @entity4 metronomic therapy preceded by standard adjuvant chemotherapy, is active and well-tolerated in @entity0 @entity1 previously treated with standard adjuvant chemotherapy.

title: Preliminary results of XXXX metronomic chemotherapy in operable @entity0 after standard adjuvant therapy - A single-arm phase II study.

answer: @entity4


abstract: PURPOSE: Little is known about the prevalence of combined @entity2 and @entity3 (CADS) in @entity0 @entity1 . Purpose was to evaluate for differences in demographic and clinical characteristics and quality of life (QOL) prior to @entity0 surgery among @entity1 classified into one of four distinct @entity2 and/or @entity3 symptom groups. METHODS: A total of 335 @entity1 completed measures of @entity2 and @entity3 and QOL prior to and for 6 months following @entity0 surgery. Growth Mixture Modelling (GMM) was used to identify subgroups of @entity1 with distinct trajectories of @entity2 and @entity3 . These results were used to create four distinct @entity2 and/or @entity3 symptom groups. Differences in demographic, clinical, and symptom characteristics, among these groups were evaluated using analyses of variance and Chi square analyses. RESULTS: A total of 44.5% of @entity1 were categorized with CADS. @entity1 with CADS were younger, non-white, had lower performance status, received neoadjuvant or adjuvant chemotherapy, had greater difficulty dealing with their disease and treatment, and reported less support from others to meet their needs. These @entity1 had lower physical, psychological, social well-being, and total QOL scores. Higher levels of @entity2 with or without @entity3 were associated with increased fears of recurrence, hopelessness, uncertainty, loss of control, and a decrease in life satisfaction. CONCLUSIONS: Findings suggest that CADS occurs in a high percentage of @entity1 following @entity0 surgery and results in a poorer QOL. Assessments of @entity2 and @entity3 are warranted prior to surgery for @entity0 .

title: Co-occurrence of XXXX and @entity3 following @entity0 surgery and its impact on quality of life.

answer: @entity2


abstract: PURPOSE: Little is known about the prevalence of combined @entity2 and @entity3 (CADS) in @entity0 @entity1 . Purpose was to evaluate for differences in demographic and clinical characteristics and quality of life (QOL) prior to @entity0 surgery among @entity1 classified into one of four distinct @entity2 and/or @entity3 symptom groups. METHODS: A total of 335 @entity1 completed measures of @entity2 and @entity3 and QOL prior to and for 6 months following @entity0 surgery. Growth Mixture Modelling (GMM) was used to identify subgroups of @entity1 with distinct trajectories of @entity2 and @entity3 . These results were used to create four distinct @entity2 and/or @entity3 symptom groups. Differences in demographic, clinical, and symptom characteristics, among these groups were evaluated using analyses of variance and Chi square analyses. RESULTS: A total of 44.5% of @entity1 were categorized with CADS. @entity1 with CADS were younger, non-white, had lower performance status, received neoadjuvant or adjuvant chemotherapy, had greater difficulty dealing with their disease and treatment, and reported less support from others to meet their needs. These @entity1 had lower physical, psychological, social well-being, and total QOL scores. Higher levels of @entity2 with or without @entity3 were associated with increased fears of recurrence, hopelessness, uncertainty, loss of control, and a decrease in life satisfaction. CONCLUSIONS: Findings suggest that CADS occurs in a high percentage of @entity1 following @entity0 surgery and results in a poorer QOL. Assessments of @entity2 and @entity3 are warranted prior to surgery for @entity0 .

title: Co-occurrence of @entity2 and XXXX following @entity0 surgery and its impact on quality of life.

answer: @entity3


abstract: PURPOSE: Little is known about the prevalence of combined @entity2 and @entity3 (CADS) in @entity0 @entity1 . Purpose was to evaluate for differences in demographic and clinical characteristics and quality of life (QOL) prior to @entity0 surgery among @entity1 classified into one of four distinct @entity2 and/or @entity3 symptom groups. METHODS: A total of 335 @entity1 completed measures of @entity2 and @entity3 and QOL prior to and for 6 months following @entity0 surgery. Growth Mixture Modelling (GMM) was used to identify subgroups of @entity1 with distinct trajectories of @entity2 and @entity3 . These results were used to create four distinct @entity2 and/or @entity3 symptom groups. Differences in demographic, clinical, and symptom characteristics, among these groups were evaluated using analyses of variance and Chi square analyses. RESULTS: A total of 44.5% of @entity1 were categorized with CADS. @entity1 with CADS were younger, non-white, had lower performance status, received neoadjuvant or adjuvant chemotherapy, had greater difficulty dealing with their disease and treatment, and reported less support from others to meet their needs. These @entity1 had lower physical, psychological, social well-being, and total QOL scores. Higher levels of @entity2 with or without @entity3 were associated with increased fears of recurrence, hopelessness, uncertainty, loss of control, and a decrease in life satisfaction. CONCLUSIONS: Findings suggest that CADS occurs in a high percentage of @entity1 following @entity0 surgery and results in a poorer QOL. Assessments of @entity2 and @entity3 are warranted prior to surgery for @entity0 .

title: Co-occurrence of @entity2 and @entity3 following XXXX surgery and its impact on quality of life.

answer: @entity0


abstract: The functional coupling of transplanted cells with host myocardial cells is a significant challenge in mesenchymal stem cell (MSC) cardiomyoplasty being related to cell survival and therapeutic outcomes. Priming of MSCs with growth factors has been reported to improve their therapeutic efficacy through gap junction-mediated mechanisms. However, the expression pattern of @entity1 ( @entity1 ) in growth factor-stimulated MSC was not previously addressed. In this study we investigated how the pre-treatment with growth factors modulates MSC ability to integrate into the host tissue after transplantation, with particular focus on the expression of @entity1 and its cellular distribution. Our results showed that stimulation of MSCs with @entity0 , @entity2 , but not TGFb, increased the level of @entity1 at both mRNA and protein levels. @entity0 stimulation resulted in a shift of the fibroblast morphology into an epithelial morphology in several well-defined areas of stimulated cells. Confocal microscopy examination revealed that the increase of @entity1 was restricted to the epithelial-like cells and did not occur in other cells. In variance, @entity2 induced a rod-shape morphology of every single cell, which achieved an extremely low cell index. @entity2 stimulation also induced a time-dependent increase in @entity1 , with a regular distribution pattern in all cells. Dye transfer assay coupled with confocal microscopy and flow cytometry analysis demonstrated functional in vitro cell coupling between @entity2 -stimulated MSCs as well as between @entity2 -stimulated cells and H9c2 cardiomyoblasts, a scenery that mimick MSC transplantation into the myocardium. We conclude that the stimulation of MSCs with @entity2 prior to transplantation may facilitate their access among the myocardial cells and increase the functional coupling between transplanted and host cells.

title: Pre-stimulation with XXXX increases in vitro functional coupling of mesenchymal stem cells with cardiac cells.

answer: @entity2


abstract: A retrospective study of @entity3 (SCC) @entity0 attending a department of oral and maxillofacial surgery was performed for the period 2000-2010. The clinical information of 100 cases treated during this period was acquired and analyzed. @entity0 survival was calculated using the Kaplan-Meier method. For these 100 cases, the total metastatic rate was 34.0% and occult metastatic rate was 27.5%. Positive lymph nodes were mostly detected at levels I-III. There was no significant difference in metastatic rate between the primary sites of maxillary gingiva and hard palate. @entity2 involving the gingival-buccal sulcus presented a significantly higher risk of @entity1 . Advanced stage (T3/4) was significantly correlated with a higher @entity1 rate. The pathological grade also showed a significant relationship with @entity1 . Twenty-four @entity0 presented regional recurrence. Elective neck dissection could significantly reduce the recurrence rate. The overall 3-year and 5-year survival rates were 66.3% and 56.7%, respectively. Both the T and the N stages had a significant impact on survival rates. Selective neck dissection from level I to III is recommended for T3/4 stage cN0 @entity0 , especially those with gingival-buccal sulcus involvement.

title: Cervical @entity1 of XXXX .

answer: @entity3


abstract: A retrospective study of @entity3 (SCC) @entity0 attending a department of oral and maxillofacial surgery was performed for the period 2000-2010. The clinical information of 100 cases treated during this period was acquired and analyzed. @entity0 survival was calculated using the Kaplan-Meier method. For these 100 cases, the total metastatic rate was 34.0% and occult metastatic rate was 27.5%. Positive lymph nodes were mostly detected at levels I-III. There was no significant difference in metastatic rate between the primary sites of maxillary gingiva and hard palate. @entity2 involving the gingival-buccal sulcus presented a significantly higher risk of @entity1 . Advanced stage (T3/4) was significantly correlated with a higher @entity1 rate. The pathological grade also showed a significant relationship with @entity1 . Twenty-four @entity0 presented regional recurrence. Elective neck dissection could significantly reduce the recurrence rate. The overall 3-year and 5-year survival rates were 66.3% and 56.7%, respectively. Both the T and the N stages had a significant impact on survival rates. Selective neck dissection from level I to III is recommended for T3/4 stage cN0 @entity0 , especially those with gingival-buccal sulcus involvement.

title: Cervical XXXX of @entity3 .

answer: @entity1


abstract: PURPOSE: To measure @entity1 ( @entity6 ) in eyes of @entity0 undergoing intraocular surgery and identify correlations with @entity5 ( @entity5 ). DESIGN: Prospective, cross-sectional study. METHODS: setting: Institutional. @entity0 population: 124 @entity0 undergoing @entity2 and/or @entity4 surgery. observation procedure: Prior to surgery, an @entity1 sensor was introduced into the anterior chamber (AC) via peripheral corneal paracentesis. The tip of the flexible fiberoptic probe was positioned for 3 measurements in all @entity0 : (1) near central corneal endothelium; (2) in mid-AC; and (3) in AC angle. In @entity0 undergoing @entity2 extraction, additional measurements were taken (4) at the anterior lens surface and (5) in the posterior chamber. main outcome measures: @entity6 measurements at 5 locations within the eye were compared to @entity5 measurements by multivariate regression analyses. RESULTS: There was a statistically significant inverse correlation between @entity5 and @entity6 in the anterior chamber angle (P  = .048). @entity6 was not significantly related to @entity5 at any other location, including beneath the central @entity3 . Regression analysis relating @entity5 to age, race, and @entity1 levels in all 5 locations in the anterior segment revealed an association of a thinner @entity3 with increasing age (P  = .007). CONCLUSIONS: Physiologic correlations with @entity5 may provide clues to understanding why a thinner @entity3 increases the risk of open @entity4 . Associations between @entity4 risk, @entity5 , and @entity6 in the AC angle suggest that exposure of the outflow system to increased @entity1 or @entity1 metabolites may increase oxidative damage to the trabecular meshwork cells, resulting in elevation of intraocular pressure.

title: Central Corneal Thickness Correlates With XXXX Levels in the @entity0 Anterior Chamber Angle.

answer: @entity1


abstract: PURPOSE: To measure @entity1 ( @entity6 ) in eyes of @entity0 undergoing intraocular surgery and identify correlations with @entity5 ( @entity5 ). DESIGN: Prospective, cross-sectional study. METHODS: setting: Institutional. @entity0 population: 124 @entity0 undergoing @entity2 and/or @entity4 surgery. observation procedure: Prior to surgery, an @entity1 sensor was introduced into the anterior chamber (AC) via peripheral corneal paracentesis. The tip of the flexible fiberoptic probe was positioned for 3 measurements in all @entity0 : (1) near central corneal endothelium; (2) in mid-AC; and (3) in AC angle. In @entity0 undergoing @entity2 extraction, additional measurements were taken (4) at the anterior lens surface and (5) in the posterior chamber. main outcome measures: @entity6 measurements at 5 locations within the eye were compared to @entity5 measurements by multivariate regression analyses. RESULTS: There was a statistically significant inverse correlation between @entity5 and @entity6 in the anterior chamber angle (P  = .048). @entity6 was not significantly related to @entity5 at any other location, including beneath the central @entity3 . Regression analysis relating @entity5 to age, race, and @entity1 levels in all 5 locations in the anterior segment revealed an association of a thinner @entity3 with increasing age (P  = .007). CONCLUSIONS: Physiologic correlations with @entity5 may provide clues to understanding why a thinner @entity3 increases the risk of open @entity4 . Associations between @entity4 risk, @entity5 , and @entity6 in the AC angle suggest that exposure of the outflow system to increased @entity1 or @entity1 metabolites may increase oxidative damage to the trabecular meshwork cells, resulting in elevation of intraocular pressure.

title: Central Corneal Thickness Correlates With @entity1 Levels in the XXXX Anterior Chamber Angle.

answer: @entity0


abstract: @entity10 are important compounds that exhibit multiple biological activities, including anti-inflammatory, antimitotic and antibacterial properties. In the present study, we have analyzed the potential anti- @entity0 activity of a @entity9 named N9 (a hybrid @entity9 - @entity6 compound) using in  vitro and in  vivo experimental @entity1 models. Here, we report N9-induced inhibition of cell proliferation and also N9-induced cell death in a concentration-dependent manner in U87-MG @entity1 cells. These effects of N9 appear to be associated with its ability to inhibit the expression of cell cycle-associated proteins, and also the augmentation in the expression of the @entity5 ( @entity5 / @entity5 ) protein, a cyclin-dependent kinase inhibitor. Additionally, N9 also potentiates the production of the pro-apoptotic markers @entity3 and @entity4 via inhibition of @entity7 . Moreover, our results show that N9 also significantly enhanced apoptosis of U87-MG cells with disruption of mitochondrial membrane potential, generation of ROS and @entity8 activation. In  vivo experiments carried out in a @entity2 xenograft model of U87-MG revealed that N9 produced a significant reduction of @entity0 volume when compared to vehicle treated @entity2 . Collectively, data demonstrate that N9 possess in  vitro and in  vivo anti- @entity0 activity, an effect that seems to involve the induction of @entity4 and @entity5 proteins, as well as, the activation of mitochondrial apoptosis pathway associated with the inhibition of protein @entity7 . Overall, this study suggests N9 is affecting a variety of intracellular pathways related to @entity0 apoptosis. Perhaps N9 or derivate molecules could represent new potential drugs for @entity0 therapeutics.

title: In  vitro and in  vivo anti- @entity1 activity of a @entity9 - XXXX hybrid.

answer: @entity6


abstract: @entity10 are important compounds that exhibit multiple biological activities, including anti-inflammatory, antimitotic and antibacterial properties. In the present study, we have analyzed the potential anti- @entity0 activity of a @entity9 named N9 (a hybrid @entity9 - @entity6 compound) using in  vitro and in  vivo experimental @entity1 models. Here, we report N9-induced inhibition of cell proliferation and also N9-induced cell death in a concentration-dependent manner in U87-MG @entity1 cells. These effects of N9 appear to be associated with its ability to inhibit the expression of cell cycle-associated proteins, and also the augmentation in the expression of the @entity5 ( @entity5 / @entity5 ) protein, a cyclin-dependent kinase inhibitor. Additionally, N9 also potentiates the production of the pro-apoptotic markers @entity3 and @entity4 via inhibition of @entity7 . Moreover, our results show that N9 also significantly enhanced apoptosis of U87-MG cells with disruption of mitochondrial membrane potential, generation of ROS and @entity8 activation. In  vivo experiments carried out in a @entity2 xenograft model of U87-MG revealed that N9 produced a significant reduction of @entity0 volume when compared to vehicle treated @entity2 . Collectively, data demonstrate that N9 possess in  vitro and in  vivo anti- @entity0 activity, an effect that seems to involve the induction of @entity4 and @entity5 proteins, as well as, the activation of mitochondrial apoptosis pathway associated with the inhibition of protein @entity7 . Overall, this study suggests N9 is affecting a variety of intracellular pathways related to @entity0 apoptosis. Perhaps N9 or derivate molecules could represent new potential drugs for @entity0 therapeutics.

title: In  vitro and in  vivo anti- @entity1 activity of a XXXX - @entity6 hybrid.

answer: @entity9