abstract: INTRODUCTION: @entity3 is usually seen in females above the age of 50 years, with a prevalence of 21/1000,(1) whereas the incidence in @entity0 aged 12-28 years is less than 5%.(2) A solitary adenoma is responsible for 80% of cases of @entity3 .(3) @entity3 is most commonly asymptomatic.(4) The incidence of @entity4 associated with @entity6 is less than 10%.(5,6) The incidence of @entity6 associated with a @entity2 is less than 5%.(7) PRESENTATION OF CASE: A 19 year old female @entity0 presented with recurrent @entity4 and @entity1 over the mandible. Complete investigative workup revealed a solitary @entity7 causing @entity6 . Surgical exploration with excision of the @entity7 was performed, following which the @entity0 recovered uneventfully. DISCUSSION: The @entity0 was initially managed as a case of @entity4 , and although not suspected initially, a high index of suspicion for @entity6 developed after a biopsy of the mandibular @entity1 showed the presence of @entity5 cells indicating the possibility of a @entity2 . Further investigations then revealed the presence of a solitary @entity7 with @entity6 which was then managed surgically. CONCLUSION: The young age of the @entity0 , and her presentation with @entity4 and a @entity2 of the mandible make this an extremely rare presentation of @entity7 .

title: @entity7 in a young female presenting as recurrent XXXX with a @entity2 of the mandible-A case study.

answer: @entity4


abstract: INTRODUCTION: @entity3 is usually seen in females above the age of 50 years, with a prevalence of 21/1000,(1) whereas the incidence in @entity0 aged 12-28 years is less than 5%.(2) A solitary adenoma is responsible for 80% of cases of @entity3 .(3) @entity3 is most commonly asymptomatic.(4) The incidence of @entity4 associated with @entity6 is less than 10%.(5,6) The incidence of @entity6 associated with a @entity2 is less than 5%.(7) PRESENTATION OF CASE: A 19 year old female @entity0 presented with recurrent @entity4 and @entity1 over the mandible. Complete investigative workup revealed a solitary @entity7 causing @entity6 . Surgical exploration with excision of the @entity7 was performed, following which the @entity0 recovered uneventfully. DISCUSSION: The @entity0 was initially managed as a case of @entity4 , and although not suspected initially, a high index of suspicion for @entity6 developed after a biopsy of the mandibular @entity1 showed the presence of @entity5 cells indicating the possibility of a @entity2 . Further investigations then revealed the presence of a solitary @entity7 with @entity6 which was then managed surgically. CONCLUSION: The young age of the @entity0 , and her presentation with @entity4 and a @entity2 of the mandible make this an extremely rare presentation of @entity7 .

title: @entity7 in a young female presenting as recurrent @entity4 with a XXXX of the mandible-A case study.

answer: @entity2


abstract: INTRODUCTION: @entity3 is usually seen in females above the age of 50 years, with a prevalence of 21/1000,(1) whereas the incidence in @entity0 aged 12-28 years is less than 5%.(2) A solitary adenoma is responsible for 80% of cases of @entity3 .(3) @entity3 is most commonly asymptomatic.(4) The incidence of @entity4 associated with @entity6 is less than 10%.(5,6) The incidence of @entity6 associated with a @entity2 is less than 5%.(7) PRESENTATION OF CASE: A 19 year old female @entity0 presented with recurrent @entity4 and @entity1 over the mandible. Complete investigative workup revealed a solitary @entity7 causing @entity6 . Surgical exploration with excision of the @entity7 was performed, following which the @entity0 recovered uneventfully. DISCUSSION: The @entity0 was initially managed as a case of @entity4 , and although not suspected initially, a high index of suspicion for @entity6 developed after a biopsy of the mandibular @entity1 showed the presence of @entity5 cells indicating the possibility of a @entity2 . Further investigations then revealed the presence of a solitary @entity7 with @entity6 which was then managed surgically. CONCLUSION: The young age of the @entity0 , and her presentation with @entity4 and a @entity2 of the mandible make this an extremely rare presentation of @entity7 .

title: XXXX in a young female presenting as recurrent @entity4 with a @entity2 of the mandible-A case study.

answer: @entity7


abstract: UNASSIGNED: Understanding the intentions of others is crucial in developing positive social relationships. Comparative @entity0 and non- @entity0 animal studies have addressed the phylogenetic origin of this ability. However, few studies have explored the importance of motion information in distinguishing others' intentions and goals in non- @entity0 primates. This study addressed whether squirrel monkeys ( @entity1 ) are able to perceive a goal-directed motion pattern-specifically, chasing-represented by two geometric objects. In Experiment 1, we trained squirrel monkeys to discriminate a "Chasing" sequence from a "Random" sequence. We then confirmed that this discrimination transferred to new stimuli ("Chasing" and "Random") in a probe test. To determine whether the monkeys used similarities of trajectory to discriminate chasing from random motion, we also presented a non-chasing "Clone" sequence in which the trajectories of the two figures were identical. Three of six monkeys were able to discriminate "Chasing" from the other sequences. In Experiment 2, we confirmed @entity0 ' recognition of chasing with the stimuli from Experiment 1. In Experiment 3, the three monkeys for which discrimination did not transfer to the new stimuli in Experiment 1 were trained to discriminate between "Chasing" and "Clone" sequences. At testing, all three monkeys had learned to discriminate chasing, and two transferred their learning to new stimuli. Our results suggest that squirrel monkeys use goal-directed motion patterns, rather than simply similarity of trajectory, to discriminate chasing. Further investigation is necessary to identify the motion characteristics that contribute to this discrimination.

title: Perception of chasing in squirrel monkeys ( XXXX ).

answer: @entity1


abstract: Western @entity2 rootworm (WCR) is a major @entity1 ( @entity1 .) pest leading to annual economic losses of more than 1 billion dollars in the United States. Transgenic @entity1 expressing insecticidal toxins derived from the bacterium @entity3 (Bt) are widely used for the management of WCR. However, cultivation of Bt-expressing @entity1 places intense selection pressure on pest populations to evolve resistance. Instances of resistance to Bt toxins have been reported in WCR. Developing genetic markers for resistance will help in characterizing the extent of existing issues, predicting where @entity0 may occur, improving insect resistance management strategies, and in designing and sustainably implementing forthcoming WCR control products. Here, we discover and validate genetic markers in WCR that are associated with resistance to the Cry3Bb1 Bt toxin. A field-derived WCR population known to be resistant to the Cry3Bb1 Bt toxin was used to generate a genetic map and to identify a genomic region associated with Cry3Bb1 resistance. Our results indicate that resistance is inherited in a nearly recessive manner and associated with a single autosomal linkage group. Markers tightly linked with resistance were validated using WCR populations collected from Cry3Bb1 @entity1 fields showing significant WCR damage from across the US @entity2 Belt. Two markers were found to be correlated with both diet (R2 = 0.14) and plant (R2 = 0.23) bioassays for resistance. These results will assist in assessing resistance risk for different WCR populations, and can be used to improve insect resistance management strategies.

title: Genetic markers for western XXXX rootworm resistance to Bt toxin.

answer: @entity2


abstract: BACKGROUND: Right atrial involvement in @entity0 with @entity3 ( @entity3 ) is a very rare phenomenon. CASE REPORT: The authors present four @entity0 with @entity3 , in whom the @entity1 involved the inferior vena cava and the right atrium. In two @entity0 the @entity1 extension was asymptomatic, while the other two had @entity2 . Therapeutic management included initial three-drug chemotherapy in three @entity0 , and primary @entity1 excision in one @entity0 , since the venous involvement had been not diagnosed. In each @entity0 , the therapeutic strategy was individualized and tailored to the course of the disease. Two @entity0 were cured. The @entity0 with bilateral @entity3 died due to disease progression. Another @entity0 died suddenly at home in the course of an intermission between consecutive cycles of successful chemotherapy. CONCLUSIONS: The extension of @entity3 to the great vessels and the right atrium indirectly affects the final outcome. Preoperative chemotherapy in @entity0 with @entity3 invading the inferior vena cava and the right atrium is the method of choice. The extent of surgery depends on the preliminary chemotherapy results.

title: Right atrial extension of XXXX .

answer: @entity3


abstract: BACKGROUND: The localized form of @entity2 annulare is usually self-limiting, resolving within 2 years. Generalized @entity2 annulare, on the other hand, runs a protracted course, with spontaneous resolution being rare. It is also characterized by a later age of onset, an increased incidence of @entity1 , poor response to therapy, and an increased prevalence of HLA @entity3 . OBJECTIVE: To assess the efficacy of monthly pulsed rifampicin, ofloxacin, and minocycline (ROM) therapy in the management of @entity2 annulare. Methods : Six biopsy proven @entity0 of @entity2 annulare were included in the study, five of the generalized variety, and one localized. Three of these @entity0 were resistant to standard modalities of treatment. All six @entity0 were treated with pulses of once monthly ROM till complete resolution of all lesions. RESULTs were analyzed in terms of complete resolution of lesions and side effects. Presence of comorbid conditions was noted. RESULT: All six @entity0 were successfully treated with 4-8 pulses of monthly ROM. None of the @entity0 reported any adverse effects. LIMITATIONS: Small sample size and the lack of a control group are limitations. CONCLUSION: Treatment with pulses of once monthly ROM caused complete resolution of lesions in both localized and generalized @entity2 annulare, even in cases recalcitrant to conventional therapy. There were no side effects in any of the @entity0 . Larger trials are needed to substantiate the efficacy of monthly ROM in @entity2 annulare.

title: Monthly rifampicin, ofloxacin, and minocycline therapy for generalized and localized XXXX annulare.

answer: @entity2


abstract: INTRODUCTION: @entity2 is the most common @entity1 and rising in the world as a health problem. Due to the criticality of this disease, in our country @entity2 prevention programs are more importance. The aim of this study was investigation of knowledge, attitude and behavior of marrying partners who were @entity2 genetic carriers in prevention of the birth of the @entity0 with @entity3 . METHODS: This study was a descriptive-analytic study. Data collection tool was a self-administered questionnaire that included 43 items. The content validity of questionnaire was investigated under the supervision of physicians, experts of health education and promotion. Its reliability was confirmed by Cronbach's Alpha test. The subjects in the study consisted of 100 marrying partners who were genetic carriers of @entity2 who referred to Premarital Counseling Center in Iranshahr City. Iranshahr is a a large city of Sistan and Balouchestan Province that located in southeast of Iran. The subjects were selected by convenience non-probability sampling method. Data analyzed using descriptive and analytic statistical tests in SPSS 16.00 and level of significance considered on a<0.05. FINDINGS: The average age of @entity0 and @entity0 that participated in this study was 21.92 and 24 years respectively. 88% of the partners had familial relationships. The educational level of most of the @entity0 (34%) was diploma and of @entity0 (44%) was pre-diploma. The research findings showed that 7% and 62% of the subjects had poor and mediocre levels of knowledge respectively. Also results showed that only 13% of them had a satisfactory behavior and educational status had a positive correlation with knowledge, behavior, perceived susceptibility and perceived severity (P<0.05). As well there was a significant statistical relationship between gender and familial relationship, and the perceived barriers of @entity0 . (p=0.01). The survey viewpoint of @entity0 showed that they believed knowledge increasing (40%), genetic counseling (33%) and premarital screening (27%) were the most important strategies for prevention of @entity2 . CONCLUSION: The perceived barriers were the strongest predictors for preventive behaviors of incidence of @entity3 in marrying partners, therefor educational interventions should focused on perceived barriers removing in Volunteer marrying partners.

title: Knowledge, Attitude and Practice of Carrier @entity2 Marriage Volunteer in Prevention of XXXX .

answer: @entity3


abstract: INTRODUCTION: @entity2 is the most common @entity1 and rising in the world as a health problem. Due to the criticality of this disease, in our country @entity2 prevention programs are more importance. The aim of this study was investigation of knowledge, attitude and behavior of marrying partners who were @entity2 genetic carriers in prevention of the birth of the @entity0 with @entity3 . METHODS: This study was a descriptive-analytic study. Data collection tool was a self-administered questionnaire that included 43 items. The content validity of questionnaire was investigated under the supervision of physicians, experts of health education and promotion. Its reliability was confirmed by Cronbach's Alpha test. The subjects in the study consisted of 100 marrying partners who were genetic carriers of @entity2 who referred to Premarital Counseling Center in Iranshahr City. Iranshahr is a a large city of Sistan and Balouchestan Province that located in southeast of Iran. The subjects were selected by convenience non-probability sampling method. Data analyzed using descriptive and analytic statistical tests in SPSS 16.00 and level of significance considered on a<0.05. FINDINGS: The average age of @entity0 and @entity0 that participated in this study was 21.92 and 24 years respectively. 88% of the partners had familial relationships. The educational level of most of the @entity0 (34%) was diploma and of @entity0 (44%) was pre-diploma. The research findings showed that 7% and 62% of the subjects had poor and mediocre levels of knowledge respectively. Also results showed that only 13% of them had a satisfactory behavior and educational status had a positive correlation with knowledge, behavior, perceived susceptibility and perceived severity (P<0.05). As well there was a significant statistical relationship between gender and familial relationship, and the perceived barriers of @entity0 . (p=0.01). The survey viewpoint of @entity0 showed that they believed knowledge increasing (40%), genetic counseling (33%) and premarital screening (27%) were the most important strategies for prevention of @entity2 . CONCLUSION: The perceived barriers were the strongest predictors for preventive behaviors of incidence of @entity3 in marrying partners, therefor educational interventions should focused on perceived barriers removing in Volunteer marrying partners.

title: Knowledge, Attitude and Practice of Carrier XXXX Marriage Volunteer in Prevention of @entity3 .

answer: @entity2


abstract: STUDY OBJECTIVES: The aim of this study is to describe the possible co-occurrence of @entity8 and generalized @entity2 , focusing on diagnostic challenge and safety of dual treatments. METHODS AND RESULTS: Four @entity0 with comorbidity for @entity8 and @entity6 are reported: in three cases the onset of @entity2 preceded @entity8 appearance, whereas in one case @entity2 spells onset was subsequent. @entity0 presented with absences, myoclonic and tonic-clonic @entity3 type: in the @entity0 with @entity3 the dual pathology was easily recognized, in the other cases the first diagnosis caused the comorbid disease to be overlooked, independent of the time-course sequence. All four @entity0 underwent neurological examination, video-electroencephalogram during which ictal and interictal @entity2 discharges were recorded, and sleep polysomnographic studies. Repeated sleep onset @entity4 periods (SOREMPs) were documented with the multiple sleep latency test (MLST) in all the four cases. All @entity0 had unremarkable brain magnetic resonance imaging studies and cerebrospinal hypocretin-1 was assessed in two @entity0 , revealing undetectable levels. The association of antiepileptic drugs and substances currently used to treat @entity8 , including @entity7 , was effective in improving @entity3 , @entity1 , and @entity5 . CONCLUSIONS: @entity8 may occur in association with @entity6 , leading to remarkable diagnostic and therapeutic challenges. Electrophysiological studies as well as a comprehensive somnologic interview can help confirm the diagnosis in @entity0 with ambiguous neurological history. @entity7 in combination with antiepileptic drugs is safe and effective in treating @entity1 .

title: Narcolepsy Type 1 and XXXX : Diagnostic and Therapeutic Challenges in Dual Cases.

answer: @entity6


abstract: Differences in age and sex distribution as well as FAB (French-American-British classification) types have been reported for @entity2 in several countries. We studied the demographics and response to treatment of @entity0 with @entity2 ( @entity2 ) and @entity1 ( @entity1 ) between 1989 and 2000 in Teresina, Piau , and compared these results with reports from Brazil and other countries. Complete data concerning 345 @entity0 (230 @entity1 , 115 @entity2 ) were reviewed. @entity2 occurred predominantly in adults (77%), with a median age of 34 years, similar to that found in the southeast of Brazil but lower than the median age in the United States and Europe (52 years). FAB distribution was similar in @entity0 and adults and @entity4 was the most common type, as also found in Japan. The high frequency of @entity3 described in most Brazilian studies and for Hispanics in the United States was not observed. Overall survival for adults was 40%, similar to other studies in Brazil. A high mortality rate was observed during induction. No clinical or hematological parameter influenced survival in the Cox model. @entity1 presented the characteristic peak of incidence between 2-8 years. Most of the cases were CD10+ pre-B @entity1 . In 25%, abnormal expression of myeloid antigens was observed. Only 10% of the @entity0 were older than 30 years. Overall survival was better for @entity0 . Age and leukocyte count were independent prognostic factors. These data demonstrate that, although there are regional peculiarities, the application of standardized treatments and good supportive care make it possible to achieve results observed in other countries for the same chemotherapy protocols.

title: XXXX in Piau  : comparison with features observed in other regions of Brazil.

answer: @entity2


abstract: UNASSIGNED: Refugees in the United States have high rates of @entity2 . Both long-term effects of the refugee experience and adjustment to the U.S. health environment may contribute. While there is significant research on health outcomes of newly resettled refugees and long-term mental health experiences of established refugees, there is currently little information about how the combined effects of the refugee experience and the U.S. health environment are related to health practices of refugees in the years and decades after resettlement. We examined cross-sectional survey data for Cambodian refugee and immigrant @entity0 35 to 60 years old (n = 160) from an established refugee community in Lowell, Massachusetts, to examine the potential contributors to health behaviors and outcomes among refugees and immigrants postresettlement. In our representative sample, we found that smoking and betel nut use were very low (4% each). Fewer than 50% of respondents walked for at least 10 minutes on 2 or more days/week. Using World Health Organization standards for overweight/ @entity1 for Asians, 73% of respondents were overweight/ @entity1 and 56% were @entity1 , indicating increased risk of @entity2 . @entity3 was also high in this sample (41%). In multivariate models, higher acculturation and age were associated with walking more often; lower education and higher acculturation were related to higher weight; and being divorced/separated or widowed and being older were related to higher risk of @entity3 . The interrelated complex of characteristics, health behaviors, and health outcomes of refugees merits a multifaceted approach to health education and health promotion for long-term refugee health.

title: Long-Term Refugee Health: Health Behaviors and Outcomes of Cambodian Refugee and Immigrant XXXX .

answer: @entity0


abstract: PURPOSE: We investigated whether bacillus Calmette-Gu  rin (BCG)-induced secretion of @entity1 b-defensin-2 ( @entity3 ) and determined whether @entity3 regulated BCG effects in the normal @entity1 bladder. MATERIALS AND METHODS: A total of 140 C57BL/6 female @entity1 were divided into 28 groups, and the experiment was performed over 3 steps. In the first step (20 groups), @entity1 bladders were stimulated with different doses of BCG (multiplicity of infection [MOI] 0, 1, 10, 30, and 100) and histological analysis was conducted in bladder specimens isolated at different times (0, 4, 8, and 24h after instillation) to determine optimal dose and time point of BCG internalization and urine @entity3 and cytokine concentration. In the second step (4 groups), BCG internalization and urine cytokine levels were measured after pretreatment of different recombinant @entity3 (rmBD2) (0, 1, 2.5, and 5ng/ml) at optimal dose and time point. In the third step (4 groups), BCG internalization and urine cytokine levels were compared between pretreatment conditions (control, rmBD2, anti- @entity3 Ab, and rmBD2+anti- @entity3 Ab). Urine was collected for estimating @entity3 levels and a multiplex analysis for 9 cytokines. Real-time polymerase chain reaction assay was used for estimating the relative BCG cell number in @entity1 bladder tissue. RESULTS: Bladder @entity0 was induced by BCG (MOI 30 and 100), which progressed to an inflammatory infiltrate composed primarily of neutrophils and increased @entity3 secretion at 4 hours after instillation. Relative BCG cell number and urinary cytokine levels (interferon-y and interleukins [IL]-2, -4, -6, and -10) response pattern was characterized by a peak at 4 hours after instillation followed by rapid decline. The levels of interferon-y, and @entity2 and relative BCG cell numbers decreased in a dose-dependent manner according to pretreatment with rmBD2 protein, and the responses were potentiated in the anti- @entity3 pretreatment group at 4 hours after BCG (MOI 30) instillation. CONCLUSION: The present results suggest that the @entity1 urothelium produces @entity3 in response to intravesicular BCG as a defense mechanism against BCG, and blocking @entity3 by an anti- @entity3 antibody increased the effectiveness of BCG.

title: XXXX b-defensin-2 may regulate the effect of bacillus Calmette-Gu  rin (BCG) in normal @entity1 bladder.

answer: @entity1


abstract: PURPOSE: We investigated whether bacillus Calmette-Gu  rin (BCG)-induced secretion of @entity1 b-defensin-2 ( @entity3 ) and determined whether @entity3 regulated BCG effects in the normal @entity1 bladder. MATERIALS AND METHODS: A total of 140 C57BL/6 female @entity1 were divided into 28 groups, and the experiment was performed over 3 steps. In the first step (20 groups), @entity1 bladders were stimulated with different doses of BCG (multiplicity of infection [MOI] 0, 1, 10, 30, and 100) and histological analysis was conducted in bladder specimens isolated at different times (0, 4, 8, and 24h after instillation) to determine optimal dose and time point of BCG internalization and urine @entity3 and cytokine concentration. In the second step (4 groups), BCG internalization and urine cytokine levels were measured after pretreatment of different recombinant @entity3 (rmBD2) (0, 1, 2.5, and 5ng/ml) at optimal dose and time point. In the third step (4 groups), BCG internalization and urine cytokine levels were compared between pretreatment conditions (control, rmBD2, anti- @entity3 Ab, and rmBD2+anti- @entity3 Ab). Urine was collected for estimating @entity3 levels and a multiplex analysis for 9 cytokines. Real-time polymerase chain reaction assay was used for estimating the relative BCG cell number in @entity1 bladder tissue. RESULTS: Bladder @entity0 was induced by BCG (MOI 30 and 100), which progressed to an inflammatory infiltrate composed primarily of neutrophils and increased @entity3 secretion at 4 hours after instillation. Relative BCG cell number and urinary cytokine levels (interferon-y and interleukins [IL]-2, -4, -6, and -10) response pattern was characterized by a peak at 4 hours after instillation followed by rapid decline. The levels of interferon-y, and @entity2 and relative BCG cell numbers decreased in a dose-dependent manner according to pretreatment with rmBD2 protein, and the responses were potentiated in the anti- @entity3 pretreatment group at 4 hours after BCG (MOI 30) instillation. CONCLUSION: The present results suggest that the @entity1 urothelium produces @entity3 in response to intravesicular BCG as a defense mechanism against BCG, and blocking @entity3 by an anti- @entity3 antibody increased the effectiveness of BCG.

title: @entity1 b-defensin-2 may regulate the effect of bacillus Calmette-Gu  rin (BCG) in normal XXXX bladder.

answer: @entity1


abstract: UNASSIGNED: Maternal high fat diet ( @entity5 ) is associated with @entity2 later in life. This study tested the hypothesis that maternal @entity5 causes programming of increased cardiac @entity6 ( @entity6 ) expression, resulting in heightened cardiac susceptibility to @entity1 in male offspring in a sex-dependent manner. Pregnant @entity0 were divided between control and @entity5 ( @entity5 ) groups. Maternal @entity5 resulted in @entity4 in only male offspring, but had no effect on cardiac systolic and diastolic function in both male and female offspring. In addition, maternal @entity5 increased heart susceptibility to @entity1 -reperfusion injury in adult male offspring, but not female offspring. There was an increase in @entity6 mRNA and protein abundance in male, but not female offspring. However, maternal @entity5 had no effect on @entity8 ( @entity8 ) expression in both male and female offspring. @entity5 resulted in decreased glucocorticoid receptors (GRs) binding to the glucocorticoid response elements (GREs) at the @entity6 promoter, which was due to decreased GRs in the heart of adult male offspring. Inhibition of @entity6 with @entity7 abrogated maternal @entity5 -induced increase in @entity3 vulnerability in male adult @entity0 . The results demonstrate that maternal @entity5 causes programming of increased @entity6 gene expression in the heart by downregulation of GR, contributing to the heightened cardiac vulnerability to @entity1 in adult male offspring in a sex-dependent manner.

title: Maternal High-Fat Diet Causes a Sex-Dependent Increase in XXXX Expression and Cardiac Dysfunction in Adult Male @entity0 Offspring.

answer: @entity6


abstract: UNASSIGNED: Maternal high fat diet ( @entity5 ) is associated with @entity2 later in life. This study tested the hypothesis that maternal @entity5 causes programming of increased cardiac @entity6 ( @entity6 ) expression, resulting in heightened cardiac susceptibility to @entity1 in male offspring in a sex-dependent manner. Pregnant @entity0 were divided between control and @entity5 ( @entity5 ) groups. Maternal @entity5 resulted in @entity4 in only male offspring, but had no effect on cardiac systolic and diastolic function in both male and female offspring. In addition, maternal @entity5 increased heart susceptibility to @entity1 -reperfusion injury in adult male offspring, but not female offspring. There was an increase in @entity6 mRNA and protein abundance in male, but not female offspring. However, maternal @entity5 had no effect on @entity8 ( @entity8 ) expression in both male and female offspring. @entity5 resulted in decreased glucocorticoid receptors (GRs) binding to the glucocorticoid response elements (GREs) at the @entity6 promoter, which was due to decreased GRs in the heart of adult male offspring. Inhibition of @entity6 with @entity7 abrogated maternal @entity5 -induced increase in @entity3 vulnerability in male adult @entity0 . The results demonstrate that maternal @entity5 causes programming of increased @entity6 gene expression in the heart by downregulation of GR, contributing to the heightened cardiac vulnerability to @entity1 in adult male offspring in a sex-dependent manner.

title: Maternal High-Fat Diet Causes a Sex-Dependent Increase in @entity6 Expression and Cardiac Dysfunction in Adult Male XXXX Offspring.

answer: @entity0


abstract: OBJECTIVE: Endoscopic third ventriculostomy (ETV) is an effective treatment for occlusive @entity4 caused by an obstruction of the CSF flow in the aqueduct or the posterior fossa. We evaluated the factors age, pathology and surgical technique on the results of the ETV. METHODS: Between November 1992 and October 2000 171 ETV have been performed in 159 @entity0 . The follow-up was evaluated in 150 @entity0 . The age ranged from 10 days to 77 years (mean age 35 years). The @entity4 was caused by @entity4 in 77 @entity0 , space-occupying lesions in 59, by intraventricular @entity2 in 11, and by other causes in 3 @entity0 . The trajectory was planned in 31 @entity0 by frame-based and in 4 @entity0 by frameless stereotaxy. RESULTS: The overall success rate of a single ETV was 71.3 % and including successful re-ETV 76.7 %. Best results were observed in adults and @entity0 older than 1 year. @entity0 demonstrated significantly worser outcomes. @entity0 with @entity4 and @entity1 compressing the aqueduct had the greatest profit from the ETV. The stereotactic guidance had no influence on the outcome and the number of severe complications. Complications were one @entity2 , three @entity2 , and one ICB, all without permanent deficit, except one permanent @entity3 . No mortality was observed.

title: The role of third ventriculostomy in the management of obstructive XXXX .

answer: @entity4


abstract: CASE REPORTS: We report a clinical and EEG study of 8 @entity0 with reflex @entity6 of @entity3 to further confirm the existence of this syndrome first described by Ricci et al in 1995. RESULTS: Between February 1990 to July 2002, we identified 64 @entity1 @entity0 with @entity2 with an onset in the first six years of life. Eight (12.5%) of these @entity0 had @entity2 stimuli sensible. The @entity2 were characterized by generalized, @entity5 triggered by tactile stimuli in six @entity0 and acoustic stimuli in two, in one of them @entity5 were triggered by both types of stimuli. The @entity2 appeared between 5 and 20 months of age. Two of the 8 @entity0 had spontaneous @entity5 during sleep. Interictal EEG was normal during wakefulness and occasional discharges were evident during sleep. In contrast, the ictal EEG during both wakefulness and sleep showed generalized spike wave and polyspike slow wave paroxysms. Neurologic examination, neuroimaging and neurometabolic studies were normal. @entity5 disappeared in 6 @entity0 after @entity4 administration and in two after clobazan administration. Antiepileptic treatment was discontinued in 6 @entity0 and no @entity2 recurrence was observed during a median follow up of 6 years. CONCLUSION: Our @entity0 presented electro clinical criteria compatible with the syndrome of reflex @entity6 of @entity3 . This syndrome could be considered to be a new reflex @entity1 or a variant of benign @entity6 in @entity3 .

title: [Reflex @entity6 in XXXX : a new reflex epilepsy syndrome or a variant of benign @entity6 in @entity3 ].

answer: @entity3


abstract: CASE REPORTS: We report a clinical and EEG study of 8 @entity0 with reflex @entity6 of @entity3 to further confirm the existence of this syndrome first described by Ricci et al in 1995. RESULTS: Between February 1990 to July 2002, we identified 64 @entity1 @entity0 with @entity2 with an onset in the first six years of life. Eight (12.5%) of these @entity0 had @entity2 stimuli sensible. The @entity2 were characterized by generalized, @entity5 triggered by tactile stimuli in six @entity0 and acoustic stimuli in two, in one of them @entity5 were triggered by both types of stimuli. The @entity2 appeared between 5 and 20 months of age. Two of the 8 @entity0 had spontaneous @entity5 during sleep. Interictal EEG was normal during wakefulness and occasional discharges were evident during sleep. In contrast, the ictal EEG during both wakefulness and sleep showed generalized spike wave and polyspike slow wave paroxysms. Neurologic examination, neuroimaging and neurometabolic studies were normal. @entity5 disappeared in 6 @entity0 after @entity4 administration and in two after clobazan administration. Antiepileptic treatment was discontinued in 6 @entity0 and no @entity2 recurrence was observed during a median follow up of 6 years. CONCLUSION: Our @entity0 presented electro clinical criteria compatible with the syndrome of reflex @entity6 of @entity3 . This syndrome could be considered to be a new reflex @entity1 or a variant of benign @entity6 in @entity3 .

title: [Reflex @entity6 in @entity3 : a new reflex epilepsy syndrome or a variant of benign @entity6 in XXXX ].

answer: @entity3


abstract: CASE REPORTS: We report a clinical and EEG study of 8 @entity0 with reflex @entity6 of @entity3 to further confirm the existence of this syndrome first described by Ricci et al in 1995. RESULTS: Between February 1990 to July 2002, we identified 64 @entity1 @entity0 with @entity2 with an onset in the first six years of life. Eight (12.5%) of these @entity0 had @entity2 stimuli sensible. The @entity2 were characterized by generalized, @entity5 triggered by tactile stimuli in six @entity0 and acoustic stimuli in two, in one of them @entity5 were triggered by both types of stimuli. The @entity2 appeared between 5 and 20 months of age. Two of the 8 @entity0 had spontaneous @entity5 during sleep. Interictal EEG was normal during wakefulness and occasional discharges were evident during sleep. In contrast, the ictal EEG during both wakefulness and sleep showed generalized spike wave and polyspike slow wave paroxysms. Neurologic examination, neuroimaging and neurometabolic studies were normal. @entity5 disappeared in 6 @entity0 after @entity4 administration and in two after clobazan administration. Antiepileptic treatment was discontinued in 6 @entity0 and no @entity2 recurrence was observed during a median follow up of 6 years. CONCLUSION: Our @entity0 presented electro clinical criteria compatible with the syndrome of reflex @entity6 of @entity3 . This syndrome could be considered to be a new reflex @entity1 or a variant of benign @entity6 in @entity3 .

title: [Reflex XXXX in @entity3 : a new reflex epilepsy syndrome or a variant of benign @entity6 in @entity3 ].

answer: @entity6


abstract: CASE REPORTS: We report a clinical and EEG study of 8 @entity0 with reflex @entity6 of @entity3 to further confirm the existence of this syndrome first described by Ricci et al in 1995. RESULTS: Between February 1990 to July 2002, we identified 64 @entity1 @entity0 with @entity2 with an onset in the first six years of life. Eight (12.5%) of these @entity0 had @entity2 stimuli sensible. The @entity2 were characterized by generalized, @entity5 triggered by tactile stimuli in six @entity0 and acoustic stimuli in two, in one of them @entity5 were triggered by both types of stimuli. The @entity2 appeared between 5 and 20 months of age. Two of the 8 @entity0 had spontaneous @entity5 during sleep. Interictal EEG was normal during wakefulness and occasional discharges were evident during sleep. In contrast, the ictal EEG during both wakefulness and sleep showed generalized spike wave and polyspike slow wave paroxysms. Neurologic examination, neuroimaging and neurometabolic studies were normal. @entity5 disappeared in 6 @entity0 after @entity4 administration and in two after clobazan administration. Antiepileptic treatment was discontinued in 6 @entity0 and no @entity2 recurrence was observed during a median follow up of 6 years. CONCLUSION: Our @entity0 presented electro clinical criteria compatible with the syndrome of reflex @entity6 of @entity3 . This syndrome could be considered to be a new reflex @entity1 or a variant of benign @entity6 in @entity3 .

title: [Reflex @entity6 in @entity3 : a new reflex epilepsy syndrome or a variant of benign XXXX in @entity3 ].

answer: @entity6


abstract: The structure of reparative tertiary dentin in @entity0 deciduous teeth has been studied. Reparative dentin is secreted by a new generation of odontoblast-like cells which have been subject to strong stimuli, e.g., @entity3 or deep active @entity2 with associated pulp @entity1 . Ground sections of 25 teeth were prepared, and contact microradiographs were produced. Another 30 teeth were demineralized, embedded in @entity4 , sectioned, and stained with @entity5 and @entity6 . Some demineralized sections from each tooth were also studied in the scanning electron microscope. Most of the teeth showed some type of tertiary dentin formation. Mineralized tissue with a varied morphology was observed. In teeth which had been subject to @entity3 , the entire pulp chamber was sometimes obliterated. Mineralization seemed to start in the incisal region, and the central part of the pulp was the last part to be obliterated. Radiolucent voids and canals were seen. The organic matrix was dense and fibrous. In the pulp chamber and especially in the root canals, resorption had often occurred, indicating that signals giving rise to odontoclasts were also present. Resorption was often followed by deposition of various amounts of cementum-like repair tissue. The cells responsible for the formation of reparative dentin are believed to be subodontoblasts or undifferentiated ectomesenchymal cells. The varied morphology of the reparative dentin, observed in the pulp of the teeth examined, indicates that different stimuli lead to induction of hard-tissue-forming cells which produce different types of hard tissue.

title: Further observations on tertiary dentin in XXXX deciduous teeth.

answer: @entity0


abstract: BACKGROUND: Recent studies have shown that @entity2 ( @entity2 ) is associated with the presence of autoantibodies (AABs) that activate the angiotensin II AT1 receptor, which could contribute to many of the symptoms of @entity2 . METHODS: To investigate the frequency and the targets of AABs in preeclamptic @entity0 (31 cases) and healthy pregnant normotensive @entity0 (29 cases) in Brazil, antibodies from serum samples were detected by a bioassay using spontaneously beating neonatal @entity1 cardiomyocytes in culture. In the cardiomyocytes, the agonistic AABs induce a positive or negative chronotropic response, mimicking the corresponding receptor agonists. The specificity of the AAB response was identified by specific receptor antagonists. RESULTS: Thirty preeclamptic @entity0 (97%) presented AABs against the angiotensin II AT1 receptor. The agonistic effect of the AAB was blocked by @entity3 and neutralized by a peptide corresponding to the second extracellular loop of this receptor. Strikingly, we discovered that all sera from the severe preeclamptic @entity0 (16 cases) contained a novel agonist-like AAB directed against the endothelin-1 ETA receptor in addition to the AABs against the angiotensin II AT1 receptor. This AAB was selectively blocked by the antagonist @entity4 , antagonized by the protein kinase C (PKC) inhibitor @entity5 and neutralized by peptides corresponding to the second extracellular loop of the endothelin-1 ETA receptor subtype. CONCLUSIONS: We described, for the first time, the presence of endothelin-1 ETA receptor AABs in @entity2 . Our results suggest that the presence of both agonistic AABs may be involved in the pathogenesis of severe @entity2 .

title: Identification of a Novel Agonist-Like Autoantibody in Preeclamptic XXXX .

answer: @entity0


abstract: BACKGROUND: Avocados are a nutrient-dense source of @entity7 ( @entity8 ) that can be used to replace @entity5 ( @entity9 ) in a diet to lower low density lipoprotein @entity3 (LDL-C). Well-controlled studies are lacking on the effect of avocado consumption on @entity2 ( @entity2 ) risk factors. METHODS AND RESULTS: A randomized, crossover, controlled feeding trial was conducted with 45 overweight or @entity1 @entity0 with baseline LDL-C in the 25th to 90th percentile. Three @entity3 -lowering diets (6% to 7% @entity9 ) were fed (5 weeks each): a lower-fat diet (LF: 24% fat); 2 moderate-fat diets (34% fat) provided similar foods and were matched for macronutrients and @entity5 : the avocado diet (AV) included one fresh Hass avocado (136 g) per day, and the moderate-fat diet (MF) mainly used high @entity6 oils to match the @entity4 content of one avocado. Compared with baseline, the reduction in LDL-C and non-high-density lipoprotein (HDL) @entity3 on the AV diet (-13.5 mg/dL, -14.6 mg/dL) was greater (P<0.05) than the MF (-8.3 mg/dL, -8.7 mg/dL) and LF (-7.4 mg/dL, -4.8 mg/dL) diets. Furthermore, only the AV diet significantly decreased LDL particle number (LDL-P, -80.1 nmol/L, P=0.0001), small dense LDL @entity3 (LDL(3+4), -4.1 mg/dL, P=0.04), and the ratio of LDL/HDL (-6.6%, P<0.0001) from baseline. CONCLUSIONS: Inclusion of one avocado per day as part of a moderate-fat, @entity3 -lowering diet has additional LDL-C, LDL-P, and non-HDL-C lowering effects, especially for small, dense LDL. Our results demonstrate that avocados have beneficial effects on cardio-metabolic risk factors that extend beyond their heart-healthy @entity4 profile. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT01235832.

title: Effect of a moderate fat diet with and without avocados on lipoprotein particle number, size and subclasses in overweight and XXXX adults: a randomized, controlled trial.

answer: @entity1


abstract: Neuropathological investigations have demonstrated brain-behavior relationships in @entity2 of the @entity2 (SDAT), but CT studies have not produced consistent findings. We hypothesized that these discouraging results were in part due to limitations in the methods of CT scan evaluations, and to non-homogeneity of @entity0 populations. The present study examined 43 out- @entity0 with the presumptive diagnosis of SDAT using 37 cognitive test measures and 3 independent CT evaluation strategies. The CT methods included a new rank ordering procedure and two previously used techniques, physical measurement and 4-point rating. Highly significant (p less than or equal to 0.01) brain-behavior correlations were attained using the ranking and rating procedures for evaluation of ventricular and cortical pathology. It was found that rank ordering has high interrater reliability and is superior to the other methods for the evaluation of the ventricular system. The physical measurement of the third ventricle is the single most powerful linear correlate of @entity1 . Measurement of cortical sulci are of no correlational significance. Multiple regression analyses indicated that global assessments are the best cognitive predictors of both ventricular and cortical pathology. Thus the present study has demonstrated brain-behavior relationships in vivo in SDAT.

title: Computed tomography evaluations of brain-behavior relationships in @entity2 of the XXXX .

answer: @entity2


abstract: Neuropathological investigations have demonstrated brain-behavior relationships in @entity2 of the @entity2 (SDAT), but CT studies have not produced consistent findings. We hypothesized that these discouraging results were in part due to limitations in the methods of CT scan evaluations, and to non-homogeneity of @entity0 populations. The present study examined 43 out- @entity0 with the presumptive diagnosis of SDAT using 37 cognitive test measures and 3 independent CT evaluation strategies. The CT methods included a new rank ordering procedure and two previously used techniques, physical measurement and 4-point rating. Highly significant (p less than or equal to 0.01) brain-behavior correlations were attained using the ranking and rating procedures for evaluation of ventricular and cortical pathology. It was found that rank ordering has high interrater reliability and is superior to the other methods for the evaluation of the ventricular system. The physical measurement of the third ventricle is the single most powerful linear correlate of @entity1 . Measurement of cortical sulci are of no correlational significance. Multiple regression analyses indicated that global assessments are the best cognitive predictors of both ventricular and cortical pathology. Thus the present study has demonstrated brain-behavior relationships in vivo in SDAT.

title: Computed tomography evaluations of brain-behavior relationships in XXXX of the @entity2 .

answer: @entity2


abstract: OBJECTIVES: This study evaluates the prevalence of @entity1 ( @entity1 ) among @entity0 with arterial @entity2 , and indirectly, the crucial impact of adopting screening for @entity1 as a standard procedure for all @entity0 diagnosed with arterial @entity2 . MATERIALS _ METHODS: This cross-sectional study was performed on a sample of @entity2 @entity0 recruited from three different university hospitals in Lebanon. Blood pressure and glycemic blood measurements were determined in all subjects. In addition, a complete clinical history and physical exam were performed. Data was entered and analyzed using SPSS 19.0. Frequencies for the different variables were calculated, and the chi-square and independent sample t-tests were conducted. RESULTS: This study included 294 @entity0 . Prevalence of @entity1 was 27%, and 23% of @entity1 @entity0 were newly diagnosed. More than half of the subjects suffering from @entity1 had uncontrolled blood pressure, contrasted with only one third of the non- @entity1 subjects with uncontrolled @entity2 . CONCLUSION: The prevalence of @entity1 in @entity0 with essential @entity2 was more than double that of the general population. Therefore, major recommendations would be to adopt strictly the @entity1 screening requirements and aggressive management among @entity2 @entity0 to minimize both the health and cost burdens associated with undetected @entity1 .

title: PREVALENCE OF DIABETES MELLITUS AMONG @entity0 WITH ESSENTIAL ARTERIAL XXXX .

answer: @entity2


abstract: OBJECTIVES: This study evaluates the prevalence of @entity1 ( @entity1 ) among @entity0 with arterial @entity2 , and indirectly, the crucial impact of adopting screening for @entity1 as a standard procedure for all @entity0 diagnosed with arterial @entity2 . MATERIALS _ METHODS: This cross-sectional study was performed on a sample of @entity2 @entity0 recruited from three different university hospitals in Lebanon. Blood pressure and glycemic blood measurements were determined in all subjects. In addition, a complete clinical history and physical exam were performed. Data was entered and analyzed using SPSS 19.0. Frequencies for the different variables were calculated, and the chi-square and independent sample t-tests were conducted. RESULTS: This study included 294 @entity0 . Prevalence of @entity1 was 27%, and 23% of @entity1 @entity0 were newly diagnosed. More than half of the subjects suffering from @entity1 had uncontrolled blood pressure, contrasted with only one third of the non- @entity1 subjects with uncontrolled @entity2 . CONCLUSION: The prevalence of @entity1 in @entity0 with essential @entity2 was more than double that of the general population. Therefore, major recommendations would be to adopt strictly the @entity1 screening requirements and aggressive management among @entity2 @entity0 to minimize both the health and cost burdens associated with undetected @entity1 .

title: PREVALENCE OF DIABETES MELLITUS AMONG XXXX WITH ESSENTIAL ARTERIAL @entity2 .

answer: @entity0


abstract: Although characteristic motor symptoms of @entity1 such as @entity2 typically improve under dopaminergic medication, deficits in higher motor control are less responsive. We here investigated the dopaminergic modulation of network dynamics underlying basic motor performance, i.e. finger tapping, and higher motor control, i.e. internally and externally cued movement preparation and selection. Twelve @entity0 , assessed ON and OFF medication, and 12 age-matched healthy subjects underwent functional magnetic resonance imaging. Dynamic causal modelling was used to assess effective connectivity in a motor network comprising cortical and subcortical regions. In particular, we investigated whether impairments in basic and higher motor control, and the effects induced by dopaminergic treatment are due to connectivity changes in (i) the mesial premotor loop comprising the supplementary motor area; (ii) the lateral premotor loop comprising lateral premotor cortex; and (iii) cortico-subcortical interactions. At the behavioural level, we observed a marked slowing of movement preparation and selection when @entity0 were internally as opposed to externally cued. Preserved performance during external cueing was associated with enhanced connectivity between prefrontal cortex and lateral premotor cortex OFF medication, compatible with a context-dependent compensatory role of the lateral premotor loop in the hypodopaminergic state. Dopaminergic medication significantly improved finger tapping speed in @entity0 , which correlated with a drug-induced coupling increase of prefrontal cortex with the supplementary motor area, i.e. the mesial premotor loop. In addition, only in the finger tapping condition, @entity0 ON medication showed enhanced excitatory influences exerted by cortical premotor regions and the thalamus upon the putamen. In conclusion, the amelioration of @entity2 by dopaminergic medication seems to be driven by enhanced connectivity within the mesial premotor loop and cortico-striatal interactions. In contrast, medication did not improve internal motor control deficits concurrent to missing effects at the connectivity level. This differential effect of dopaminergic medication on the network dynamics underlying motor control provides new insights into the clinical finding that in @entity1 dopaminergic drugs especially impact on @entity2 but less on executive functions.

title: Dopaminergic modulation of motor network dynamics in XXXX .

answer: @entity1


abstract: UNASSIGNED: Mucins are important in tumorigenesis and expressional alterations of mucins are common in @entity0 @entity1 . A membrane-bound mucin @entity7 and secreted mucins @entity5 and @entity6 are known to involve in tumorigenesis, but their mutation status in @entity1 remains unknown. Aim of this study was to explore whether @entity5 , @entity6 and @entity7 genes are mutated and expressionally altered in gastric (GC) and @entity2 ( @entity2 ). In a public database, we found that @entity7 and @entity6 genes had mononucleotide repeats in the coding sequences that might be mutation targets in the @entity1 with @entity3 ( @entity4 ). We analyzed the mutations in 90 GC and 141 @entity2 (high @entity4 ( @entity4 ) or stable @entity4 /low @entity4 ( @entity4 )) by single-strand conformation polymorphism analysis and DNA sequencing. In the present study, we found @entity7 frameshift mutations (14.7% of GC and 15.2% of @entity2 with @entity4 ), MUC 7 frameshift mutations (2.9% of GC with @entity4 ) and @entity5 frameshift mutations (8.8% of GC and 3.8% of @entity2 with @entity4 ). These mutations were not found in in @entity4 (0/118). Additionally, we analyzed intratumoral heterogeneity (ITH) of @entity7 mutation in 16 @entity2 and found that seven @entity2 (43.8%) harbored regional ITH of @entity7 . We also analyzed @entity7 expression in GC and @entity2 by immunohistochemistry. Negative @entity7 expression was identified in 15-41% of the GC and @entity2 irrespective of @entity4 status. Of note, the negative expression was more common in those with @entity7 mutations. We identified alterations of MUC genes at various levels (frameshift mutations, genetic ITH and expression loss), which together might play a role in tumorigenesis of GC and @entity2 with @entity4 . Our data suggest that mutation analysis in multiple regions is needed for a better evaluation of mutation status in @entity2 with @entity4 .

title: Frameshift Mutations of @entity7 Gene in Gastric and its Regional Heterogeneity in Gastric and XXXX .

answer: @entity2


abstract: UNASSIGNED: Mucins are important in tumorigenesis and expressional alterations of mucins are common in @entity0 @entity1 . A membrane-bound mucin @entity7 and secreted mucins @entity5 and @entity6 are known to involve in tumorigenesis, but their mutation status in @entity1 remains unknown. Aim of this study was to explore whether @entity5 , @entity6 and @entity7 genes are mutated and expressionally altered in gastric (GC) and @entity2 ( @entity2 ). In a public database, we found that @entity7 and @entity6 genes had mononucleotide repeats in the coding sequences that might be mutation targets in the @entity1 with @entity3 ( @entity4 ). We analyzed the mutations in 90 GC and 141 @entity2 (high @entity4 ( @entity4 ) or stable @entity4 /low @entity4 ( @entity4 )) by single-strand conformation polymorphism analysis and DNA sequencing. In the present study, we found @entity7 frameshift mutations (14.7% of GC and 15.2% of @entity2 with @entity4 ), MUC 7 frameshift mutations (2.9% of GC with @entity4 ) and @entity5 frameshift mutations (8.8% of GC and 3.8% of @entity2 with @entity4 ). These mutations were not found in in @entity4 (0/118). Additionally, we analyzed intratumoral heterogeneity (ITH) of @entity7 mutation in 16 @entity2 and found that seven @entity2 (43.8%) harbored regional ITH of @entity7 . We also analyzed @entity7 expression in GC and @entity2 by immunohistochemistry. Negative @entity7 expression was identified in 15-41% of the GC and @entity2 irrespective of @entity4 status. Of note, the negative expression was more common in those with @entity7 mutations. We identified alterations of MUC genes at various levels (frameshift mutations, genetic ITH and expression loss), which together might play a role in tumorigenesis of GC and @entity2 with @entity4 . Our data suggest that mutation analysis in multiple regions is needed for a better evaluation of mutation status in @entity2 with @entity4 .

title: Frameshift Mutations of XXXX Gene in Gastric and its Regional Heterogeneity in Gastric and @entity2 .

answer: @entity7


abstract: INTRODUCTION: The majority of @entity0 who have a first @entity2 are treated by Primary Care physicians. The aim of this study was to evaluate the use of antidepressants and referrals to mental health and the treatment modifications made by psychiatrists. MATERIAL AND METHODS: A descriptive, retrospective study was conducted on @entity0 from 64 Primary Care clinics, distributed in five Spanish provinces. The clinical history data, regarding use of antidepressants, criteria for referral, and response of @entity1 services were evaluated from June 2008 to June 2011. RESULTS: The study included 324 @entity0 . The most commonly prescribed medication was @entity4 , with selective @entity3 reuptake inhibitors (SSRI) making up 73.5% of the total. More than two-thirds (69.7%) of the @entity0 were on treatment for at least 6 months, with no reason recorded for the 40.4% drop-outs. A large majority of professionals (76.9%) wait at least 3 weeks before modifying the medication, especially changing antidepressant. The Primary Care physicians referred 39.2% of @entity0 to psychiatry, although much of these referrals (43.9%) had no justification. There was a lower referral rate to psychology (23.1%). An antidepressant was given to a large number of @entity0 on multiple medications, without taking into account the risk of interactions in a high percentage. CONCLUSIONS: The Primary Care physician appropriately uses the antidepressants of the first choice, but does not pay attention to the risks in complex @entity0 . There must be an appropriate duration of treatment and an improvement of the criteria for referral to mental health services.

title: [Management of a first XXXX in the primary care setting. Use of antidepressants and referrals].

answer: @entity2


abstract: @entity2 are the most common and aggressive types of @entity1 in @entity0 brain, of which the prognosis remains dismal because of their biological behavior. The involvement of miRNAs in tumorigenesis of various kinds of @entity1 drives us to explore new miRNAs related to @entity2 . We measured expression level of @entity5  -3p by qRT-PCR in @entity0 @entity2 and @entity1 brain tissues and found that higher level of @entity5  -3p in @entity2 tissues of higher grade. Biological functions of @entity5  -3p on @entity2 cells were investigated by @entity3 assay, flow cytometry and transwell assay. We discovered the cell lines transfected with @entity5  -3p ASO (antisense oligonucleotide) had retarded proliferation and invasion but enhanced apoptosis ability. We searched on-line tool Targetscan and selected @entity4 ( @entity7 ) as a putative target. Luciferase reporter was employed to confirm the binding sites in 3'UTR region of @entity6 for @entity5  -3p. The correlation between expression of @entity6 and @entity5  -3p was determined by western blotting and qRT-PCR both in cell lines and @entity0 samples. Results showed @entity6 was a direct target of @entity5  -3p and expression levels of @entity6 and @entity5  -3p were negatively correlated. Finally, @entity6 largely abrogated the effects of @entity5  -3p on proliferation, invasion and apoptosis of @entity2 cells in rescue experiments, which verified the role of @entity6 in @entity5  -3p regulating @entity2 biological behavior. In conclusion, our data suggest the expression level of @entity5  -3p is positively related to @entity2 grade and downregulation of @entity5  -3p affects proliferation, invasion and apoptosis of @entity2 cells by targeting @entity6 . We identified @entity5  -3p as a putative therapeutic target and @entity6 as a potential @entity1 suppressor.

title: Downregulation of miR-95-3p inhibits proliferation, and invasion promoting apoptosis of @entity2 cells by targeting XXXX .

answer: @entity6


abstract: @entity2 are the most common and aggressive types of @entity1 in @entity0 brain, of which the prognosis remains dismal because of their biological behavior. The involvement of miRNAs in tumorigenesis of various kinds of @entity1 drives us to explore new miRNAs related to @entity2 . We measured expression level of @entity5  -3p by qRT-PCR in @entity0 @entity2 and @entity1 brain tissues and found that higher level of @entity5  -3p in @entity2 tissues of higher grade. Biological functions of @entity5  -3p on @entity2 cells were investigated by @entity3 assay, flow cytometry and transwell assay. We discovered the cell lines transfected with @entity5  -3p ASO (antisense oligonucleotide) had retarded proliferation and invasion but enhanced apoptosis ability. We searched on-line tool Targetscan and selected @entity4 ( @entity7 ) as a putative target. Luciferase reporter was employed to confirm the binding sites in 3'UTR region of @entity6 for @entity5  -3p. The correlation between expression of @entity6 and @entity5  -3p was determined by western blotting and qRT-PCR both in cell lines and @entity0 samples. Results showed @entity6 was a direct target of @entity5  -3p and expression levels of @entity6 and @entity5  -3p were negatively correlated. Finally, @entity6 largely abrogated the effects of @entity5  -3p on proliferation, invasion and apoptosis of @entity2 cells in rescue experiments, which verified the role of @entity6 in @entity5  -3p regulating @entity2 biological behavior. In conclusion, our data suggest the expression level of @entity5  -3p is positively related to @entity2 grade and downregulation of @entity5  -3p affects proliferation, invasion and apoptosis of @entity2 cells by targeting @entity6 . We identified @entity5  -3p as a putative therapeutic target and @entity6 as a potential @entity1 suppressor.

title: Downregulation of miR-95-3p inhibits proliferation, and invasion promoting apoptosis of XXXX cells by targeting @entity6 .

answer: @entity2


abstract: BACKGROUND: The initial treatment of @entity10 ( @entity10 ) has generally been limited to serotonergic agents, cognitive-behavioral therapy (CBT), or a combination of the two. These findings were supported by the POTS study for @entity10 in @entity0 and adolescents. However, treatment with serotonergic agents or CBT can take several weeks before benefit is seen; severe cases of @entity10 may require more immediate treatment. CASE REPORT: The authors present a case of severe @entity10 in an adolescent that required immediate treatment due to her critical medical condition. The @entity0 's symptoms included not eating or taking medications or fluids by mouth due to fears of contamination. A medical hospitalization was previously required due to @entity9 . As treatment with an SSRI would not have quick enough onset and the @entity0 was initially resistant to participating in CBT, the @entity0 was psychiatrically hospitalized and first started on liquid @entity7 . After several doses of @entity7 , the @entity0 was able to participate in CBT and start @entity11 . DISCUSSION: The authors discuss the differential diagnosis of such a @entity0 , including the continuum of @entity10 symptoms and @entity4 . The authors discuss the different treatment options, including the utilization of inpatient @entity2 hospitalization. The authors discuss the potential risks and benefits of using atypical antipsychotics in lieu of @entity8 for the initial treatment of severe adolescent @entity10 . The authors also discuss other current treatment recommendations and rationale for the treatment that was pursued. CONCLUSIONS: This @entity0 received benefit of her symptoms relatively quickly with @entity2 hospitalization and an atypical antipsychotic. The diagnosis of a @entity5 should be considered. These treatment options must be weighed against the risks of atypical antipsychotics, including @entity1 , @entity6 , and @entity3 ; @entity8 also have their risks and benefits. Additionally, the cost of time and finances of inpatient hospitalization must be considered. More research is needed regarding the short- and long-term efficacy and safety of antipsychotics in the treatment of @entity10 in the @entity0 and adolescent population.

title: A case of severe adolescent XXXX treated with inpatient hospitalization, @entity7 and @entity11 .

answer: @entity10


abstract: BACKGROUND: The initial treatment of @entity10 ( @entity10 ) has generally been limited to serotonergic agents, cognitive-behavioral therapy (CBT), or a combination of the two. These findings were supported by the POTS study for @entity10 in @entity0 and adolescents. However, treatment with serotonergic agents or CBT can take several weeks before benefit is seen; severe cases of @entity10 may require more immediate treatment. CASE REPORT: The authors present a case of severe @entity10 in an adolescent that required immediate treatment due to her critical medical condition. The @entity0 's symptoms included not eating or taking medications or fluids by mouth due to fears of contamination. A medical hospitalization was previously required due to @entity9 . As treatment with an SSRI would not have quick enough onset and the @entity0 was initially resistant to participating in CBT, the @entity0 was psychiatrically hospitalized and first started on liquid @entity7 . After several doses of @entity7 , the @entity0 was able to participate in CBT and start @entity11 . DISCUSSION: The authors discuss the differential diagnosis of such a @entity0 , including the continuum of @entity10 symptoms and @entity4 . The authors discuss the different treatment options, including the utilization of inpatient @entity2 hospitalization. The authors discuss the potential risks and benefits of using atypical antipsychotics in lieu of @entity8 for the initial treatment of severe adolescent @entity10 . The authors also discuss other current treatment recommendations and rationale for the treatment that was pursued. CONCLUSIONS: This @entity0 received benefit of her symptoms relatively quickly with @entity2 hospitalization and an atypical antipsychotic. The diagnosis of a @entity5 should be considered. These treatment options must be weighed against the risks of atypical antipsychotics, including @entity1 , @entity6 , and @entity3 ; @entity8 also have their risks and benefits. Additionally, the cost of time and finances of inpatient hospitalization must be considered. More research is needed regarding the short- and long-term efficacy and safety of antipsychotics in the treatment of @entity10 in the @entity0 and adolescent population.

title: A case of severe adolescent @entity10 treated with inpatient hospitalization, @entity7 and XXXX .

answer: @entity11


abstract: BACKGROUND: The initial treatment of @entity10 ( @entity10 ) has generally been limited to serotonergic agents, cognitive-behavioral therapy (CBT), or a combination of the two. These findings were supported by the POTS study for @entity10 in @entity0 and adolescents. However, treatment with serotonergic agents or CBT can take several weeks before benefit is seen; severe cases of @entity10 may require more immediate treatment. CASE REPORT: The authors present a case of severe @entity10 in an adolescent that required immediate treatment due to her critical medical condition. The @entity0 's symptoms included not eating or taking medications or fluids by mouth due to fears of contamination. A medical hospitalization was previously required due to @entity9 . As treatment with an SSRI would not have quick enough onset and the @entity0 was initially resistant to participating in CBT, the @entity0 was psychiatrically hospitalized and first started on liquid @entity7 . After several doses of @entity7 , the @entity0 was able to participate in CBT and start @entity11 . DISCUSSION: The authors discuss the differential diagnosis of such a @entity0 , including the continuum of @entity10 symptoms and @entity4 . The authors discuss the different treatment options, including the utilization of inpatient @entity2 hospitalization. The authors discuss the potential risks and benefits of using atypical antipsychotics in lieu of @entity8 for the initial treatment of severe adolescent @entity10 . The authors also discuss other current treatment recommendations and rationale for the treatment that was pursued. CONCLUSIONS: This @entity0 received benefit of her symptoms relatively quickly with @entity2 hospitalization and an atypical antipsychotic. The diagnosis of a @entity5 should be considered. These treatment options must be weighed against the risks of atypical antipsychotics, including @entity1 , @entity6 , and @entity3 ; @entity8 also have their risks and benefits. Additionally, the cost of time and finances of inpatient hospitalization must be considered. More research is needed regarding the short- and long-term efficacy and safety of antipsychotics in the treatment of @entity10 in the @entity0 and adolescent population.

title: A case of severe adolescent @entity10 treated with inpatient hospitalization, XXXX and @entity11 .

answer: @entity7


abstract: Seventy @entity0 homozygous for Hb S (SS) and their 111 heterozygous ( @entity2 ) parents were evaluated through their erythrocytic indices, hemoglobin composition, and occasionally through in vitro Hb chain synthesis values. Three groups of SS @entity0 and of @entity2 parents were identified based on differences in degree of microcytosis (MCV) and (degree of hypochromia ( @entity4 ) values. The level of Hb S in the Hb S heterozygotes showed a trimodal distribution. Five SS @entity0 had an @entity3 homozygosity (alpha(0) alpha/alpha(0) alpha; beta(s)/beta(s) which was characterized by a distinct microcytosis and hypochromia (MCV), less than or equal to 70 fl; @entity4 , less than or equal to 22 pp). Nine SS @entity0 had an @entity3 heterozygosity (alpha(0)/alpha/alpha alpha; beta(s)/beta(s)) with an MCV value of 71 to 78 fl, and an @entity4 value of 21.3 to 26.5 pg. Four @entity2 parents had an @entity3 homozygosity with values of MCV less than or equal to 71 fl and @entity4 less than or equal to 23.5. The level of Hb S was less than 31%. Thirty-nine @entity2 parents had an @entity3 heterozygosity characterized by an MCV value of 72 to 79 fl, an @entity4 value of 23.6 to 26.5, and a level of Hb S ranging between 31.0 and 36.8%. The Hb A2 level in SS @entity0 was significantly correlated with the RBC counts and the MCV and @entity4 (r = 0.38, -0.52, and -0.47, respectively). Significant correlations in @entity2 parents were also noted between the MCV, @entity4 , RBC, and Hb S percentages (r = 0.62, 0.68, and -0.49, respectively). Although the data are limited, the simultaneous occurrence of an alpha-thal-2 homozygosity seems to decrease the level of Hb F in @entity1 . The presence of an alpha-thal-2 heterozygosity or homozygosity together with an SS or @entity2 condition resulted in identifiable hematologic phenotypes.

title: @entity3 and the variability of hematological values in @entity0 with XXXX .

answer: @entity1


abstract: Seventy @entity0 homozygous for Hb S (SS) and their 111 heterozygous ( @entity2 ) parents were evaluated through their erythrocytic indices, hemoglobin composition, and occasionally through in vitro Hb chain synthesis values. Three groups of SS @entity0 and of @entity2 parents were identified based on differences in degree of microcytosis (MCV) and (degree of hypochromia ( @entity4 ) values. The level of Hb S in the Hb S heterozygotes showed a trimodal distribution. Five SS @entity0 had an @entity3 homozygosity (alpha(0) alpha/alpha(0) alpha; beta(s)/beta(s) which was characterized by a distinct microcytosis and hypochromia (MCV), less than or equal to 70 fl; @entity4 , less than or equal to 22 pp). Nine SS @entity0 had an @entity3 heterozygosity (alpha(0)/alpha/alpha alpha; beta(s)/beta(s)) with an MCV value of 71 to 78 fl, and an @entity4 value of 21.3 to 26.5 pg. Four @entity2 parents had an @entity3 homozygosity with values of MCV less than or equal to 71 fl and @entity4 less than or equal to 23.5. The level of Hb S was less than 31%. Thirty-nine @entity2 parents had an @entity3 heterozygosity characterized by an MCV value of 72 to 79 fl, an @entity4 value of 23.6 to 26.5, and a level of Hb S ranging between 31.0 and 36.8%. The Hb A2 level in SS @entity0 was significantly correlated with the RBC counts and the MCV and @entity4 (r = 0.38, -0.52, and -0.47, respectively). Significant correlations in @entity2 parents were also noted between the MCV, @entity4 , RBC, and Hb S percentages (r = 0.62, 0.68, and -0.49, respectively). Although the data are limited, the simultaneous occurrence of an alpha-thal-2 homozygosity seems to decrease the level of Hb F in @entity1 . The presence of an alpha-thal-2 heterozygosity or homozygosity together with an SS or @entity2 condition resulted in identifiable hematologic phenotypes.

title: XXXX and the variability of hematological values in @entity0 with @entity1 .

answer: @entity3


abstract: Seventy @entity0 homozygous for Hb S (SS) and their 111 heterozygous ( @entity2 ) parents were evaluated through their erythrocytic indices, hemoglobin composition, and occasionally through in vitro Hb chain synthesis values. Three groups of SS @entity0 and of @entity2 parents were identified based on differences in degree of microcytosis (MCV) and (degree of hypochromia ( @entity4 ) values. The level of Hb S in the Hb S heterozygotes showed a trimodal distribution. Five SS @entity0 had an @entity3 homozygosity (alpha(0) alpha/alpha(0) alpha; beta(s)/beta(s) which was characterized by a distinct microcytosis and hypochromia (MCV), less than or equal to 70 fl; @entity4 , less than or equal to 22 pp). Nine SS @entity0 had an @entity3 heterozygosity (alpha(0)/alpha/alpha alpha; beta(s)/beta(s)) with an MCV value of 71 to 78 fl, and an @entity4 value of 21.3 to 26.5 pg. Four @entity2 parents had an @entity3 homozygosity with values of MCV less than or equal to 71 fl and @entity4 less than or equal to 23.5. The level of Hb S was less than 31%. Thirty-nine @entity2 parents had an @entity3 heterozygosity characterized by an MCV value of 72 to 79 fl, an @entity4 value of 23.6 to 26.5, and a level of Hb S ranging between 31.0 and 36.8%. The Hb A2 level in SS @entity0 was significantly correlated with the RBC counts and the MCV and @entity4 (r = 0.38, -0.52, and -0.47, respectively). Significant correlations in @entity2 parents were also noted between the MCV, @entity4 , RBC, and Hb S percentages (r = 0.62, 0.68, and -0.49, respectively). Although the data are limited, the simultaneous occurrence of an alpha-thal-2 homozygosity seems to decrease the level of Hb F in @entity1 . The presence of an alpha-thal-2 heterozygosity or homozygosity together with an SS or @entity2 condition resulted in identifiable hematologic phenotypes.

title: @entity3 and the variability of hematological values in XXXX with @entity1 .

answer: @entity0


abstract: UNASSIGNED: Some @entity2 ( @entity2 ) @entity0 treated with subthalamic nucleus deep brain stimulation ( @entity4 -DBS) develop new-onset @entity1 . We examined whether clinical EEG recordings can be used to predict @entity1 in @entity2 @entity0 undergoing @entity4 -DBS. In this retrospective study, we used the Grand Total EEG (GTE)-score (short and total) to evaluate pre- and postoperative EEGs. In @entity2 @entity0 undergoing @entity4 -DBS (N  =  30), cognitive functioning was measured using Mini-Mental State Test and DemTect before and after surgery. Severity of motor impairment was assessed using the Unified @entity2 Rating Scale-III. @entity0 were classified into @entity0 with or without @entity1 after @entity4 -DBS surgery. Epidemiological data, pre- and postoperative EEG recordings as well as neuropsychological and neurological data, electrode positions and the third ventricle width were compared. A logistic regression model was used to identify predictors of @entity1 . Motor deficits significantly improved from pre- to post-surgery, while the mean GTE-scores increased significantly. Six @entity0 developed @entity1 4-12  months postoperatively. These @entity0 had significantly higher preoperative GTE-scores than @entity0 without @entity1 , although preoperative cognitive functioning was comparable. Electrode positions, @entity3 and neurological data did not differ between groups. Logistic regression analysis identified the GTE-score as a significant predictor of postoperative @entity1 . Data suggest that the preoperative GTE-score can be used to identify @entity2 @entity0 that are at high risk for developing @entity1 after @entity4 -DBS surgery even though their preoperative cognitive state was normal.

title: Deep brain stimulation and @entity1 in XXXX : The predictive value of electroencephalography.

answer: @entity2


abstract: UNASSIGNED: Some @entity2 ( @entity2 ) @entity0 treated with subthalamic nucleus deep brain stimulation ( @entity4 -DBS) develop new-onset @entity1 . We examined whether clinical EEG recordings can be used to predict @entity1 in @entity2 @entity0 undergoing @entity4 -DBS. In this retrospective study, we used the Grand Total EEG (GTE)-score (short and total) to evaluate pre- and postoperative EEGs. In @entity2 @entity0 undergoing @entity4 -DBS (N  =  30), cognitive functioning was measured using Mini-Mental State Test and DemTect before and after surgery. Severity of motor impairment was assessed using the Unified @entity2 Rating Scale-III. @entity0 were classified into @entity0 with or without @entity1 after @entity4 -DBS surgery. Epidemiological data, pre- and postoperative EEG recordings as well as neuropsychological and neurological data, electrode positions and the third ventricle width were compared. A logistic regression model was used to identify predictors of @entity1 . Motor deficits significantly improved from pre- to post-surgery, while the mean GTE-scores increased significantly. Six @entity0 developed @entity1 4-12  months postoperatively. These @entity0 had significantly higher preoperative GTE-scores than @entity0 without @entity1 , although preoperative cognitive functioning was comparable. Electrode positions, @entity3 and neurological data did not differ between groups. Logistic regression analysis identified the GTE-score as a significant predictor of postoperative @entity1 . Data suggest that the preoperative GTE-score can be used to identify @entity2 @entity0 that are at high risk for developing @entity1 after @entity4 -DBS surgery even though their preoperative cognitive state was normal.

title: Deep brain stimulation and XXXX in @entity2 : The predictive value of electroencephalography.

answer: @entity1


abstract: UNASSIGNED: Shivering frequency scales predictably with body mass and is 10 times higher in a @entity0 than a moose. The link between shivering frequency and body mass may lie in the tuning of muscle elastic properties. @entity4 functions as a muscle 'spring', so shivering frequency may be linked to @entity4 's structure. The @entity2 with @entity3 (mdm) @entity0 is characterized by a deletion in @entity4 's N2A region. @entity0 that are homozygous for the mdm mutation have a lower body mass, stiffer gait and reduced lifespan compared with their wild-type and heterozygous siblings. We characterized thermoregulation in these @entity0 by measuring metabolic rate and @entity1 frequency during shivering. Mutants were heterothermic at ambient temperatures of 20-37  C while wild-type and heterozygous @entity0 were homeothermic. Metabolic rate increased at smaller temperature differentials (i.e. the difference between body and ambient temperatures) in mutants than in non-mutants. The difference between observed @entity1 frequencies and shivering frequencies predicted by body mass was significantly larger for mutant @entity0 than for wild-type or heterozygous @entity0 , even after accounting for differences in body temperature. Together, the heterothermy in mutants, the increase in metabolic rate at low temperature differentials and the decreased @entity1 frequency demonstrate the thermoregulatory challenges faced by @entity0 with the mdm mutation. Oscillatory frequency is proportional to the square root of stiffness, and we observed that mutants had lower active muscle stiffness in vitro. The lower @entity1 frequencies in mutants are consistent with reduced active muscle stiffness and suggest that @entity4 affects the tuning of shivering frequency.

title: Shiver me XXXX ! Elucidating @entity4 's role in shivering thermogenesis.

answer: @entity4


abstract: UNASSIGNED: Shivering frequency scales predictably with body mass and is 10 times higher in a @entity0 than a moose. The link between shivering frequency and body mass may lie in the tuning of muscle elastic properties. @entity4 functions as a muscle 'spring', so shivering frequency may be linked to @entity4 's structure. The @entity2 with @entity3 (mdm) @entity0 is characterized by a deletion in @entity4 's N2A region. @entity0 that are homozygous for the mdm mutation have a lower body mass, stiffer gait and reduced lifespan compared with their wild-type and heterozygous siblings. We characterized thermoregulation in these @entity0 by measuring metabolic rate and @entity1 frequency during shivering. Mutants were heterothermic at ambient temperatures of 20-37  C while wild-type and heterozygous @entity0 were homeothermic. Metabolic rate increased at smaller temperature differentials (i.e. the difference between body and ambient temperatures) in mutants than in non-mutants. The difference between observed @entity1 frequencies and shivering frequencies predicted by body mass was significantly larger for mutant @entity0 than for wild-type or heterozygous @entity0 , even after accounting for differences in body temperature. Together, the heterothermy in mutants, the increase in metabolic rate at low temperature differentials and the decreased @entity1 frequency demonstrate the thermoregulatory challenges faced by @entity0 with the mdm mutation. Oscillatory frequency is proportional to the square root of stiffness, and we observed that mutants had lower active muscle stiffness in vitro. The lower @entity1 frequencies in mutants are consistent with reduced active muscle stiffness and suggest that @entity4 affects the tuning of shivering frequency.

title: Shiver me @entity4 ! Elucidating XXXX 's role in shivering thermogenesis.

answer: @entity4


abstract: UNASSIGNED: @entity5 ( @entity5 ) is a rare and severe @entity0 . Inhibition of @entity2 sulfotransferase (CST) has been proposed as a promising new therapeutic strategy for the treatment of @entity5 . CST catalyzes the transfer of a @entity1 group from the coenzyme @entity8 ( @entity8 ) to @entity2 yielding @entity9 and @entity10 ( @entity3 ). So far only a few weak CST inhibitors have been described. The goal of the present study was to establish a suitable assay for identifying and characterizing novel CST inhibitors. To this end, we developed and optimized a capillary electrophoresis (CE) based assay for monitoring the catalytic activity of CST by measuring the formation of PAP. A sample matrix consisting of 5mM @entity4 buffer with about 0.0001% @entity6 at pH 7.4 and a background electrolyte (BGE) containing 75mM @entity4 buffer with 0.002% @entity6 at pH 5.6 were utilized to achieve a stacking effect for PAP by dynamic pH junction. This led to a limit of detection for the enzymatic product PAP of 66.6nM. The CE method was sensitive, robust, and suitable for CST inhibitor screening, Ki value determination, and enzyme kinetic studies. Selected reference compounds were tested in order to validate the assay, including the substrates @entity2 and @entity7 , and the inhibitor Congo Red. The newly developed CE method will be useful for the identification and development of novel CST inhibitors which are urgently needed for the treatment of @entity5 .

title: A capillary electrophoresis method with dynamic pH junction stacking for the monitoring of XXXX sulfotransferase.

answer: @entity2


abstract: @entity6 is a new class Ic antiarrhythmic agent currently being investigated in the United States. It is generally well tolerated. We administered @entity6 to 16 @entity0 with @entity4 ( @entity4 ) that had been refractory to conventional antiarrhythmic drug therapy. Three of these 16 @entity0 developed electrically provoked incessant @entity4 during treatment with @entity6 without other evidence of @entity2 . These @entity3 subsided after @entity7 was administered. @entity6 therapy was discontinued in each case. Incessant @entity4 did not develop in any of these @entity0 in the absence of antiarrhythmic drugs or on antiarrhythmic drugs other than @entity6 . Alternative effective treatment was identified for each @entity0 . Although @entity4 was initially provoked by pacing in each of these @entity0 , these observations suggest that @entity6 , like some other class Ic drugs, may favor the development of incessant @entity4 in occasional @entity0 . This appears most likely to occur in @entity0 with @entity1 and prior sustained @entity4 or @entity5 .

title: Aggravation of electrically provoked XXXX during treatment with @entity6 .

answer: @entity4


abstract: @entity6 is a new class Ic antiarrhythmic agent currently being investigated in the United States. It is generally well tolerated. We administered @entity6 to 16 @entity0 with @entity4 ( @entity4 ) that had been refractory to conventional antiarrhythmic drug therapy. Three of these 16 @entity0 developed electrically provoked incessant @entity4 during treatment with @entity6 without other evidence of @entity2 . These @entity3 subsided after @entity7 was administered. @entity6 therapy was discontinued in each case. Incessant @entity4 did not develop in any of these @entity0 in the absence of antiarrhythmic drugs or on antiarrhythmic drugs other than @entity6 . Alternative effective treatment was identified for each @entity0 . Although @entity4 was initially provoked by pacing in each of these @entity0 , these observations suggest that @entity6 , like some other class Ic drugs, may favor the development of incessant @entity4 in occasional @entity0 . This appears most likely to occur in @entity0 with @entity1 and prior sustained @entity4 or @entity5 .

title: Aggravation of electrically provoked @entity4 during treatment with XXXX .

answer: @entity6


abstract: UNASSIGNED: This paper presents a novel @entity0 -specific algorithm for detection of @entity2 in @entity1 @entity0 from a single-channel intra-cranial electroencephaolograph (iEEG) recording. Instead of extracting features from the EEG signal, first the EEG signal is filtered by a prediction error filter (PEF) to compute a prediction error signal. A two-level wavelet decomposition of the prediction error signal leads to two detail signals and one approximate signal. Eight features are extracted every one second using a 2-second window with a 50% overlap. These features are input to two different types of classifiers: a linear support vector machine (SVM) classifier and an AdaBoost classifier. The algorithm is tested using the intra-cranial EEG (iEEG) from the Freiburg database. It is shown that the proposed algorithm can achieve a sensitivity of 95.0% and an average false positive rate (FPR) of 0.124 per hour, using the linear SVM classifier. The AdaBoost classifier achieves a sensitivity of 98.75% and an average FPR of 0.075 per hour. These results are obtained with leave-one-out cross-validation. In addition, for 13 out of 18 @entity0 , the AdaBoost classifier requires only one feature, while it requires 4 features for the remaining 5 @entity0 .

title: XXXX detection using wavelet decomposition of the prediction error signal from a single channel of intra-cranial EEG.

answer: @entity2


abstract: Magnetic resonance imaging is a technique for the diagnosis and classification of @entity6 . Discrete compactness is a morphological feature of two-dimensional and three-dimensional objects. This measure determines the compactness of a discretized object depending on the sum of the areas of the connected voxels and has been used for understanding the morphology of @entity1 . We hypothesized that regarding @entity6 , we may improve the @entity1 grade classification. We analyzed the values in 20 @entity0 with different subtypes of primary @entity6 : @entity5 , @entity7 , and @entity4 multiforme subdivided into the contrast-enhanced and the @entity1 regions. The preliminary results show an inverse relationship between the compactness value and the @entity1 grade of @entity2 . Astrocytomas exhibit a mean of [Formula: see text], whereas @entity7 exhibit a mean of [Formula: see text]. In contrast, the contrast-enhanced region of the @entity4 presented a mean of [Formula: see text], and the @entity3 region presented a mean of [Formula: see text]. However, the volume and area of the enclosing surface did not show a relationship with the @entity1 grade of the @entity2 . Discrete compactness appears to be a stable characteristic between primary @entity6 of different @entity1 grades, because similar values were obtained from different @entity0 with the same type of @entity1 .

title: Neuromorphometry of primary XXXX by magnetic resonance imaging.

answer: @entity6


abstract: This study aimed to investigate imaging statistical approaches for classifying three-dimensional (3-D) osteoarthritic morphological variations among 169 @entity1 ( @entity1 ) condyles. Cone-beam computed tomography scans were acquired from 69 subjects with long-term @entity1 ( @entity0 ), 15 subjects at initial diagnosis of @entity0 , and 7 healthy controls. Three-dimensional surface models of the condyles were constructed and SPHARM-PDM established correspondent points on each model. Multivariate analysis of covariance and direction-projection-permutation (DiProPerm) were used for testing statistical significance of the differences between the groups determined by clinical and radiographic diagnoses. Unsupervised classification using hierarchical agglomerative clustering was then conducted. Compared with healthy controls, @entity0 average condyle was significantly smaller in all dimensions except its anterior surface. Significant flattening of the lateral pole was noticed at initial diagnosis. We observed areas of 3.88-mm bone resorption at the superior surface and 3.10-mm bone apposition at the anterior aspect of the long-term @entity0 average model. DiProPerm supported a significant difference between the healthy control and @entity0 group ([Formula: see text]). Clinically meaningful unsupervised classification of @entity1 condylar morphology determined a preliminary diagnostic index of 3-D osteoarthritic changes, which may be the first step towards a more targeted diagnosis of this condition.

title: Diagnostic index of three-dimensional osteoarthritic changes in XXXX condylar morphology.

answer: @entity1


abstract: BACKGROUND: The aim of this study was to assess sentinel node biopsy (SNB) results in @entity2 ( @entity2 ) regarding intraoperative staging of the disease and pathological @entity1 features. MATERIAL AND METHODS: The study was conducted on the basis of 132 SNBs in @entity2 . The elements of intraoperative staging of the disease and pathological @entity1 features were compared with accur--acy, sensitivity and false negative results of SNB in @entity2 by means of ROC curves and the tests for population proportions. RESULTS: ROC curve analysis did not reveal any statistical significance for @entity1 measurements (all p > 0.05). Statistically significantly worse results in sensitivity (not in accuracy) were achieved for @entity1 in comparison with T2 @entity1 (83% vs 89%, p = 0.0066). Statistically significantly worse results in accuracy (not in sensitivity) of the method were obtained in the cases of involved lymph nodes (78% vs 100%, p < 0.0001), infiltration of the lymph node capsule (80% vs 97%, p = 0.0023) and infiltration of the perinodal tissue (73% vs 97%, p = 0.0002). The analyses of SNB sensitivity and accuracy in combination with other features showed no statistical significance (all p > 0.05). CONCLUSIONS: The sensitivity of the method is significantly worse for @entity1 with deeper infiltration of intestinal wall. The presence of nodal metastases, lymph node capsule and perinodal invasion significantly affects the accuracy results of SNB in @entity2 . The problem of qualifying @entity0 for the procedure in regard to the other analysed features, however, remains open and requires further analysis.

title: The Influence of Intraoperative Factors and Histopathological Staging on the Performance of Sentinel Node Biopsy in XXXX .

answer: @entity2


abstract: The clinical features of 115 @entity0 from 90 families with @entity11 are described. Onset of symptoms was before the age of 25 (mean 10.52) years in all the index cases. An analysis of early cases suggested that limb and @entity8 and @entity6 in the legs were the only consistent diagnostic criteria within five years of presentation. @entity10 , signs of @entity5 in the legs and @entity4 and vibration sense are not necessarily present during the first five years of symptoms, but appear to develop eventually in all cases. Scoliosis and ECG evidence of @entity2 were found in over two-thirds of the @entity0 studied; pes cavus, distal amyotrophy, @entity7 , @entity3 and @entity9 were all less frequent. The disorder was gradually progressive in all cases. The mean age of losing the ability to walk was 25 years; 95 per cent were chair-bound by the age of 44 years. About 10 per cent of the @entity0 had @entity1 which was controlled by oral hypoglycaemic drugs in one quarter. @entity1 appeared to be associated with a higher incidence of @entity7 and @entity9 . @entity1 also clustered within sibships; the risk of an individual with @entity11 developing @entity1 if an affected sib has it is over 40 per cent. Similarly, @entity2 ran true within affected members of the same sibship, but there were instances of discordance which suggest that the development of the non-neurological features of @entity11 may be controlled by modifying genes rather than heterogeneity of the main gene. Segregation analysis and an increased consanguinity rate amongst parents of @entity0 (5.55 per cent) confirmed that this disorder is of autosomal recessive inheritance. A study of 101 first degree relatives of the @entity0 with @entity11 failed to demonstrate any neurological or electrocardiographic abnormalities which could be ascribed to the heterozygous state.

title: XXXX : a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features.

answer: @entity11


abstract: Surgery is the treatment of choice in @entity0 with a diagnosis of @entity4 ( @entity4 ). A pivotal of eligibility for resection is the early stage of the disease and histopathological assessment. The performance status and comorbidities in population, predominated by elderly @entity0 , also influence the therapeutic decisions. In some @entity1 @entity0 @entity3 coexists, characterized by a decrease in lung function. Then the preoperative evaluation is particularly important, for both the risk of @entity2 , lung function and quality of life postoperatively. Recently several recommendations for preoperative evaluation of @entity0 being considered for surgery were published. The guidelines of BTS (2001, 2010), ACCP (2007, 2013) and joint recommendations of ERS and ESTS (2009) have been based on the currently available research results, and indicated the algorithms. The recommendations ERS/ESTS and ACCP distinguished cardiac risk estimation in all @entity0 , which should precede the evaluation of lung function. According to the latest recommendations (ACCP 2013) the next step is spirometry, DLCO measurement and calculation of predicted postoperative values for both parameters. The low-technology exercise tests (stair climbing, shuttle walk test) were assigned as valuable to discriminate @entity0 at low and intermediate perioperative risk. The cardiopulmonary exercise test (CPET) is recommended to be performed at the final qualification for surgery in @entity0 with high risk. It was also stressed that therapeutic decisions should be taken multidisciplinary, allowing to estimate the risk of complications and to evaluate the expected quality of life in the postoperative time.

title: [Assessment of respiratory function in the qualification for XXXX surgery].

answer: @entity1


abstract: UNASSIGNED: Background and study aims: Confocal laser endomicroscopy (CLE) has been shown to predict relapse in @entity2 in remission, but little is currently known about its role in @entity1 . The aim of this study was to identify reproducible CLE features in @entity0 with @entity1 and to examine whether these are risk factors for relapse. @entity0 and methods: This was a single-center prospective feasibility study of CLE imaging in @entity0 with @entity1 . CLE imaging was performed in the terminal ileum and four colorectal sites, and was correlated with histopathology and macroscopic appearance. Clinical relapse, defined as the need for treatment escalation or surgical intervention, was recorded during follow-up. Results: The study included 50 @entity0 : 39 with @entity1 (20 in remission), and 11 controls. Ileal @entity3 leakage and microerosions were significantly more frequent in @entity0 with endoscopically active @entity1 compared with @entity0 with inactive @entity1 and controls (P=0.005 and (P=0.006, respectively). The same applied to colorectal @entity3 leakage and vascular alterations ((P=0.043 and (P=0.034, respectively). During a 12-month follow-up period, ileal @entity3 leakage and microerosions were significant risk factors for relapse in the subgroup of @entity0 in remission (log rank (P=0.009 and (P=0.007, respectively) as well as in the entire group of @entity0 with @entity1 (log rank (P=0.006 and (P=0.01, respectively). Inter- and intraobserver reproducibility was almost perfect (k>0.80) or substantial (k>0.60) for the majority of CLE parameters. Conclusions: CLE can identify reproducible microscopic changes in the terminal ileum that are risk factors for relapse in @entity0 with otherwise inactive @entity1 . TRIAL REGISTRATION: ClinicalTrials.gov (NCT01738529).

title: Confocal laser endomicroscopy: a novel method for prediction of relapse in XXXX .

answer: @entity1