abstract: Among 1992 @entity0 undergoing carotid endarterectomy from January 1972 through December 1984, 57 operations were performed in 51 @entity0 for recurrent @entity3 . Thirty-four of these cases had undergone initial surgery at this institution while 23 had endarterectomy elsewhere. Fifty-two of the 57 operations were for symptomatic disease while five were for evidence of a progressing lesion. All operative procedures were monitored with intracerebral blood flow measurements and continuous electroencephalograms. Twenty-three @entity0 required intraoperative shunting. There were no complications related to shunt usage or to the period of temporary occlusion in @entity0 who did not require shunting. Recurrent @entity6 was related to intimal @entity8 in 14 cases, recurrent @entity5 with interluminal thrombi or degenerated plaque in 27, unexplained soft @entity4 in eight, proximal scarring in six, and to @entity2 in two. Intimal @entity8 was the most common cause for @entity1 within 2 years from the date of surgery and developed earlier in @entity0 with a primary closure than in @entity0 closed with a patch graft. The operative complication rate was 10.5% or 4 times the risk of surgery for primary @entity5 at this institution. Complications were attributed primarily to intraoperative and postoperative @entity7 events related to apparent increased thrombogenicity of these vessels. The highest complication rate occurred in the group of @entity0 undergoing surgery for thrombotic material in the internal carotid artery, either primary or with underlying @entity5 . There were no neurological complications in the group with @entity8 . The authors' experience suggests that on-lay patch grafting without endarterectomy should be used in @entity0 with @entity8 . @entity0 with complicated recurrent @entity5 can be treated with endarterectomy and patch grafting, but interposition vein grafts should be considered in cases in which the vessels are extensively damaged by the recurrent plaque or with an unexplained @entity4 at the site of previous endarterectomy.

title: Recurrent XXXX . Results and complications of 57 operations.

answer: @entity3


abstract: Fifty @entity0 with @entity2 were evaluated prospectively using cultures of aspirates from the advancing edge of @entity2 , skin biopsy specimens, and blood. Potential microbial pathogens were isolated in 13 @entity0 . Biopsy specimen cultures were positive in ten @entity0 , while aspirate and blood cultures were positive in five and two, respectively. Aspirate, biopsy, or blood cultures were more often positive in @entity0 with apparent primary lesions than in @entity0 without such lesions. Apparent primary sites of @entity1 were identified and cultured in 24 @entity0 . beta-Hemolytic streptococci were isolated from 17 primary lesions, and coagulase-positive staphylococci were present in 13. Both organisms were isolated from ten primary lesions. Among @entity0 with positive aspirate, biopsy, and/or blood cultures, the same pathogens were also isolated from primary sites in ten of ten @entity0 . Clinical features, including temperature, white blood cell count, and erythrocyte sedimentation rate, were not predictive of positive aspirate, biopsy, or blood cultures. These cultures provided no microbiologic information that was not obtainable from culture of primary lesions.

title: Microbiologic evaluation of XXXX in adults.

answer: @entity2


abstract: OBJECTIVE: Our purpose was to evaluate the pathologic features and outcome of pregnancy complicated by a persistent @entity5 that was managed conservatively or with surgical intervention. STUDY DESIGN: A review was performed of @entity0 who were seen with an @entity5 in pregnancy from January 1988 to June 1994. We included @entity0 with simple or complex masses > or = 6 cm that were persistent on ultrasonographic evaluation. We excluded cysts that spontaneously resolved by 16 weeks' gestation and those diagnosed after delivery. RESULTS: Thirty-one @entity0 of 43,372 deliveries were identified with persistent @entity5 that met the above criteria. Nineteen (59%) of these @entity0 had operative intervention, whereas 12 (41%) were managed conservatively. Of the @entity0 who had surgery, nine had functional cysts, six had mature cystic @entity2 , and four had other benign cysts. Complications within 12 hours of surgery included one @entity4 and one @entity0 with @entity3 of membranes. Twelve @entity0 were managed nonsurgically. Seven @entity0 had conservative management, whereas five @entity0 had percutaneous drainage of simple cysts (negative results on cytologic study) that were symptomatic. CONCLUSIONS: Although the incidence of @entity1 in pregnancy is low, the incidental finding of an @entity5 in pregnancy is becoming more common. Because complications of abdominal surgery are increased in pregnancy, surgical management of this prenatal complication needs to be reconsidered. Our data support a randomized clinical study to determine optimal management of an @entity5 in pregnancy.

title: The management of a persistent XXXX in pregnancy.

answer: @entity5


abstract: Administration of chemotherapy is delayed by most clinicians until complete recovery from surgery because it is generally feared that cytotoxic drugs impair wound healing, reduce resistance against @entity5 , and may hinder the recovery process. However, clinical experience is lacking. This clinical study examines the effect of perioperative administration of @entity8 on the healing of wounds and intestinal anastomoses and the recovery process in general. Forty @entity0 with advanced @entity9 entered the study. Intravenous bolus administration of 0.5 g of @entity8 was started during surgery. The @entity0 underwent a variety of abdominal operations for palliation or cure. A total of 22 gastric and enteric anastomoses were performed. One half gram of @entity8 diluted in 150 mL of 5% @entity6 solution was given intravenously over one hour daily for ten days postoperatively. The @entity0 were carefully evaluated for any alteration in the postoperative recovery. Thirty-eight of the 40 @entity0 received the full course of @entity8 . Twenty-one @entity0 had an uneventful postoperative course. Eighteen had mild to moderate @entity2 unrelated to @entity8 administration. One @entity0 died of @entity7 16 days after abdominoperineal resection. Surgical wounds healed without complications in 37 @entity0 . One case of @entity3 occurred after sigmoidectomy. Two @entity0 developed wound infections that healed secondarily. All 22 @entity0 with anastomoses recovered without any evidence of leakage. Colostomies and gastrostomies functioned as anticipated. Side effects attributed to @entity8 appeared in seven of the @entity0 ; in only two of the @entity0 were complications life-threatening, involving @entity4 . All @entity0 recovered after discontinuation of @entity8 therapy and with supportive treatment. On the whole, the course of recovery of this group was no different than expected from @entity0 with advanced @entity1 who were undergoing extensive surgery. Based on this study, it seems that @entity8 administration during and immediately after surgery has no deleterious effect on wound healing and recovery.

title: The effects of perioperative XXXX administration on convalescence and wound healing.

answer: @entity8


abstract: @entity3 ( @entity3 ) is an important regulator of bone formation. Gain-of-function mutations in the @entity3 gene result in @entity2 which include @entity5 ( @entity5 ), the most common form of dwarfism, in which skull, appendicular and axial skeletons are affected. The skeletal phenotype of @entity0 with @entity5 showed defective proliferation and differentiation of the chondrocytes in the growth plate cartilage. Both endochondral and membranous ossification processes are disrupted during development. At cellular level, @entity3 mutations induce increased phosphorylation of the @entity4 kinase receptor @entity3 , which correlate with an enhanced activation of its downstream signaling pathways. Potential therapeutic strategies have emerged for @entity5 . Several preclinical studies have been conducted such as the @entity6 ( @entity6 ) analog ( @entity8 ), intermittent parathyroid hormone injections, soluble @entity3 therapy, and @entity7 and statin treatments. Among the putative targets to antagonize @entity3 signaling, @entity6 (or @entity8 ) is one of the most promising strategies. @entity8 acts as a key regulator of longitudinal bone growth by downregulating the mitogen-activated protein kinase pathway, which is activated as a result of a @entity3 gain-of-function mutation. Preclinical studies showed that @entity8 treatment led to a large improvement in skeletal parameters in Fgfr3Y367C/+ @entity1 mimicking @entity5 . In 2014, a clinical trial (phase 2) of @entity8 in pediatric @entity0 with @entity5 has started. This first clinical trial marks the first big step towards real treatment for these @entity0 .

title: XXXX Analog as Therapy for @entity5 .

answer: @entity6


abstract: @entity3 ( @entity3 ) is an important regulator of bone formation. Gain-of-function mutations in the @entity3 gene result in @entity2 which include @entity5 ( @entity5 ), the most common form of dwarfism, in which skull, appendicular and axial skeletons are affected. The skeletal phenotype of @entity0 with @entity5 showed defective proliferation and differentiation of the chondrocytes in the growth plate cartilage. Both endochondral and membranous ossification processes are disrupted during development. At cellular level, @entity3 mutations induce increased phosphorylation of the @entity4 kinase receptor @entity3 , which correlate with an enhanced activation of its downstream signaling pathways. Potential therapeutic strategies have emerged for @entity5 . Several preclinical studies have been conducted such as the @entity6 ( @entity6 ) analog ( @entity8 ), intermittent parathyroid hormone injections, soluble @entity3 therapy, and @entity7 and statin treatments. Among the putative targets to antagonize @entity3 signaling, @entity6 (or @entity8 ) is one of the most promising strategies. @entity8 acts as a key regulator of longitudinal bone growth by downregulating the mitogen-activated protein kinase pathway, which is activated as a result of a @entity3 gain-of-function mutation. Preclinical studies showed that @entity8 treatment led to a large improvement in skeletal parameters in Fgfr3Y367C/+ @entity1 mimicking @entity5 . In 2014, a clinical trial (phase 2) of @entity8 in pediatric @entity0 with @entity5 has started. This first clinical trial marks the first big step towards real treatment for these @entity0 .

title: @entity6 Analog as Therapy for XXXX .

answer: @entity5


abstract: UNASSIGNED: @entity1 are among the most frequently diagnosed @entity1 and radiotherapy represents one of the main treatment options. The irradiation field usually encompasses healthy intestinal tissue, especially of distal large bowel, thus inducing gastrointestinal (GI) radiation-induced @entity4 . Indeed, up to half of radiation-treated @entity0 say that their quality of life is affected by GI symptoms (e.g., @entity8 , @entity5 ). The constellation of GI symptoms - from transient to long-term, from mild to very severe - experienced by @entity0 who underwent radiation treatment for a @entity7 have been comprised in the @entity3 ( @entity3 ). A correct and evidence-based therapeutic approach of @entity0 experiencing GI radiation-induced @entity4 is mandatory. Therapeutic non-surgical strategies for @entity3 can be summarized in two broad categories, i.e., medical and endoscopic. Of note, most of the studies have investigated the management of radiation-induced @entity8 . @entity0 with clinically significant @entity8 (i.e., causing @entity6 ) should firstly be considered for medical management (i.e., @entity10 enemas, @entity9 and hyperbaric @entity2 ); in case of failure, endoscopic treatment should be implemented. This latter should be considered the first choice in case of acute, transfusion requiring, @entity8 . More well-performed, high quality studies should be performed, especially the role of medical treatments should be better investigated as well as the comparative studies between endoscopic and hyperbaric @entity2 treatments.

title: XXXX : Updates on treatment options.

answer: @entity3


abstract: A @entity0 is reported who presented with a typical @entity8 . Before this illness, the @entity0 had suffered from @entity9 at the age of 15 months. A @entity6 was present which included severe @entity5 , @entity4 , and @entity3 . There were no relatives with a similar disease. Clinically, there was a frank recurrent @entity8 with occasional @entity2 . Radiographic barium studies showed delayed transit, hypomotility of the intestines, and gross distension of the esophagus, stomach, small intestine, and colon. Histological examination of the gastrointestinal tract revealed a normal appearance of the mucosa; however, there was a @entity7 with abnormalities of the plexuses. Both the submucosal and the myenteric plexuses were reduced in number and size. They showed a decreased number of ganglion cells, proliferation of Schwann cells and infiltration by lymphocytes. The abnormalities were most strikingly present in the esophagus and the small intestine. The @entity1 resulting in clinical pseudoobstruction is proposed to be part of the generalised neurological pathology as a late sequel to the @entity9 .

title: Chronic XXXX as a possible sequel to encephalitis.

answer: @entity8


abstract: BACKGROUND: Few data are available on the long-term effects of @entity2 on 24-h blood pressure (BP) and left ventricular mass in overweight @entity1 @entity0 . METHODS: A total of 181 never-treated overweight @entity1 subjects (body mass index, 25 to 39 kg/m(2), office BP 145/94 +/- 12/7 mm Hg) had 24-h BP monitoring and echocardiography twice, at baseline and after 3.8 +/- 2 years (minimum 1 year). None of the subjects received antihypertensive drugs during the follow-up. Main outcome measures were changes in 24-h BP and in left ventricular mass. RESULTS: Percent change in body weight had a direct relationship with 24-h BP changes (r = 0.35 and 0.31 for systolic and diastolic BP, respectively; both P <.001). The associations with office BP changes (r = 0.13, P =.10 for systolic BP; r = 0.15, P =.06 for diastolic BP) were significantly weaker (both P <.01, z test). The @entity0 who lost weight during follow-up (n = 106) had a significantly lower increase in 24-h BP (+0.6 +/- 9/ +0.2 +/- 6 v +4.9 +/- 9/ +2.7 +/- 7 mm Hg for systolic/diastolic BP, both P <.01) and in left ventricular mass (-3 +/- 30 g v +9 +/- 32 g, P <.02) than the remaining subjects. In a multiple linear regression, a 10% @entity2 independently predicted a 4.3/3.8 mm Hg decrease in 24-h systolic/diastolic BP. CONCLUSIONS: Long-term @entity2 determines a sustained BP reduction during the 24 h and a decrease in left ventricular mass in overweight @entity1 subjects. The relation of @entity2 with ambulatory BP changes is closer than that with office BP.

title: Effect of body weight changes on 24-hour blood pressure and left ventricular mass in XXXX : a 4-year follow-up.

answer: @entity1


abstract: BACKGROUND: From a 55-year experience with about 4,000 @entity0 treated for @entity1 , we have identified 18 @entity0 (0.5%) who received definitive treatment for @entity1 arising in the sublingual glands. @entity0 AND METHODS: @entity0 ages ranged from 35 to 76 years (median 59), and @entity0 and @entity0 were equally represented. All had @entity1 , which included @entity4 (9 @entity0 ), @entity5 (5 @entity0 ), and @entity2 (4 @entity0 ). An asymptomatic swelling was the most common complaint (7 @entity0 ); the @entity1 was incidentally discovered by a dentist in 4 others. For all @entity0 , the treatment delay ranged from 3 to 24 months, but only 3 had lesions that extended beyond the confines of the floor of the mouth. All were treated surgically by resections, which were peroral in 4 @entity0 , transcervical in 5, and pull-through type (including the submandibular gland) in 7. The remaining 2 @entity0 had composite procedures. In 3 more recently treated @entity0 , pull-through resections were followed by @entity3 repair involving transmandibular sutures. This technique has proved useful and will be described in detail. RESULTS: Results in this small @entity0 cohort have been most encouraging. Local recurrence occurred in 3 @entity0 who succumbed 11 months, 27 months, and 21 years after initial treatment. Fourteen others remain alive and well 20 months to 20 years (median 74 months) posttreatment, and the remaining @entity0 was recurrence free when he died of unrelated causes 7 years after resection. CONCLUSION: This small experience confirms the rarity of @entity1 and attests to the good results in terms of function and survival that can be anticipated with adequate surgical treatment when the lesion is relatively small.

title: Treating XXXX of the sublingual glands, including a useful technique for repair of the floor of the mouth after resection.

answer: @entity1


abstract: The relationship between @entity2 consumption and physical fitness was analyzed using data from the baseline examination of the Coronary Artery Disease Risk Development In Young Adults study (CARDIA), a longitudinal study of the evolution of risk factors for @entity1 in Black and White @entity0 and @entity0 aged 18-30 years. Two parameters of submaximal exercise treadmill testing were evaluated: time to heart rate 130 and duration of the treadmill test. In @entity0 and @entity0 qualified for treadmill testing, time to reach heart rate 130 was positively associated with @entity3 intake. The relationship between fitness and @entity3 intake persisted in sex-specific analysis after adjustment for age, ethnicity, systolic blood pressure, sum of subscapular and triceps skinfolds, and physical activity level. The magnitude and strength of the relationship were greater in @entity0 than in @entity0 . A negative interaction between @entity3 intake and smoking status was evident. Linear regression coefficients in @entity0 were 0.29 sec to heart rate 130/ml @entity3 /day in nonsmokers and -0.06 sec to heart rate 130/ml @entity3 /day in smokers. Linear regression coefficients in @entity0 were 1.07 sec to heart rate 130/ml @entity3 /day in nonsmokers and 0.23 sec to heart rate 130/ml @entity3 /day in smokers. @entity0 and @entity0 who smoked showed 31 sec longer time to heart rate 130, regardless of @entity3 intake. Mean daily @entity3 intake was positively associated with duration of treadmill testing in @entity0 , but weakly associated with duration in @entity0 . These results show increased physical fitness as @entity3 intake increased in @entity0 and nonsmoking @entity0 and mildly decreased physical fitness as @entity3 consumption increases among @entity0 who smoke.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX consumption and physical fitness among young adults.

answer: @entity2


abstract: We studied the effect of intravenous (IV) thiamylal or @entity6 on the increases in serum @entity8 , @entity2 kinase (CK), and @entity3 induced by @entity5 under @entity4 anesthesia. Ninety @entity0 were divided into three groups. In Group O, @entity5 (1.0 mg/kg) was administered after an the inhaled induction of anesthesia with @entity4 . In Group T, thiamylal (4.0-5.0 mg/kg), and in Group K, @entity6 (1.5-2.0 mg/kg) was injected prior to @entity5 administration. Anesthesia was maintained with @entity4 , @entity7 , and @entity1 . @entity8 increased in Group O at 60 min to 855 ng/mL (median) and CK to 98.6 IU/L. These increases were significantly higher than those of Group T (110 ng/mL and 66.4 IU/L) and Group K (110 ng/mL and 57.0 IU/L). @entity3 increased in Group O only. There was no significant difference between Groups T and K for any of the three values. These results indicate that IV thiamylal and @entity6 both suppress the increases of @entity8 , CK, and @entity3 , and that in cases when @entity5 is used, both drugs can help to avoid myoglobinemia and limit the increases of CK and @entity3 .

title: The effect of XXXX or thiamylal on @entity5 -induced myoglobinemia under @entity4 anesthesia in adults.

answer: @entity6


abstract: We studied the effect of intravenous (IV) thiamylal or @entity6 on the increases in serum @entity8 , @entity2 kinase (CK), and @entity3 induced by @entity5 under @entity4 anesthesia. Ninety @entity0 were divided into three groups. In Group O, @entity5 (1.0 mg/kg) was administered after an the inhaled induction of anesthesia with @entity4 . In Group T, thiamylal (4.0-5.0 mg/kg), and in Group K, @entity6 (1.5-2.0 mg/kg) was injected prior to @entity5 administration. Anesthesia was maintained with @entity4 , @entity7 , and @entity1 . @entity8 increased in Group O at 60 min to 855 ng/mL (median) and CK to 98.6 IU/L. These increases were significantly higher than those of Group T (110 ng/mL and 66.4 IU/L) and Group K (110 ng/mL and 57.0 IU/L). @entity3 increased in Group O only. There was no significant difference between Groups T and K for any of the three values. These results indicate that IV thiamylal and @entity6 both suppress the increases of @entity8 , CK, and @entity3 , and that in cases when @entity5 is used, both drugs can help to avoid myoglobinemia and limit the increases of CK and @entity3 .

title: The effect of @entity6 or thiamylal on @entity5 -induced myoglobinemia under XXXX anesthesia in adults.

answer: @entity4


abstract: We studied the effect of intravenous (IV) thiamylal or @entity6 on the increases in serum @entity8 , @entity2 kinase (CK), and @entity3 induced by @entity5 under @entity4 anesthesia. Ninety @entity0 were divided into three groups. In Group O, @entity5 (1.0 mg/kg) was administered after an the inhaled induction of anesthesia with @entity4 . In Group T, thiamylal (4.0-5.0 mg/kg), and in Group K, @entity6 (1.5-2.0 mg/kg) was injected prior to @entity5 administration. Anesthesia was maintained with @entity4 , @entity7 , and @entity1 . @entity8 increased in Group O at 60 min to 855 ng/mL (median) and CK to 98.6 IU/L. These increases were significantly higher than those of Group T (110 ng/mL and 66.4 IU/L) and Group K (110 ng/mL and 57.0 IU/L). @entity3 increased in Group O only. There was no significant difference between Groups T and K for any of the three values. These results indicate that IV thiamylal and @entity6 both suppress the increases of @entity8 , CK, and @entity3 , and that in cases when @entity5 is used, both drugs can help to avoid myoglobinemia and limit the increases of CK and @entity3 .

title: The effect of @entity6 or thiamylal on XXXX -induced myoglobinemia under @entity4 anesthesia in adults.

answer: @entity5


abstract: OBJECTIVE: To evaluate the effect of physiotherapy on functional limitation in an observational cohort of early @entity1 . METHODS: Design: prospective population-based cohort study. @entity0 : 708 @entity0 with early @entity1 between 2007 and 2010 naive of TNF blockers. INTERVENTION: early physiotherapy defined by at least eight supervised sessions of physical therapy during the first six months. MEASUREMENTS: the primary outcome was functional improvement defined by a relative improvement of at least 20% in BASFI at six months. Secondary outcomes were improvement in BASFI at one and two years and ASAS20 response criteria at six months. STATISTICAL ANALYSIS: a propensity score of having physiotherapy was developed and multivariate analysis using propensity score weighting were used to assess the effect of physiotherapy on outcome. RESULTS: Overall, 166 (24%) @entity0 had physiotherapy during the first six months. After using propensity score weighting, there was no functional improvement on the primary outcome in @entity0 treated with early physical therapy (relative risk [IC95%]: 1.15 [0.91-1.45]). No differences were observed on secondary outcomes (relative risk [IC95%]: 0.94 [0.80-1.11]). CONCLUSIONS: It seems there is no functional benefit for @entity0 with @entity1 to be treated early by physiotherapy in daily practice, even though the efficacy of physiotherapy has been shown in several randomized controlled studies.

title: Evaluation of physiotherapy in a prospective cohort of early XXXX . Data from the DESIR cohort.

answer: @entity1


abstract: OBJECTIVES: Rituximab (RTX) is increasingly used in @entity0 with @entity3 ( @entity3 ) and other severe @entity4 ( @entity4 ). In practice, many clinicians are reluctant to prescribe RTX in @entity0 with low B-cell counts because of the presumed risk of @entity2 . The aim of this study was therefore to investigate whether B-cell counts before treatment or retreatment with RTX predict the occurrence of @entity2 . METHODS: Observational, single-centre study of 161 @entity0 treated with RTX for @entity3 and other @entity4 at a tertiary hospital. @entity5 + B-cell counts were assessed by flow cytometry and multivariate statistical analysis adjusted for various potential predictors was performed. RESULTS: The rate of severe @entity2 was 5.9/100 @entity0 -years in @entity3 @entity0 and 24.9 in non- @entity3 @entity4 (P<0.001). Low B-cell counts at the time of RTX infusion were not associated with subsequent severe (HR=0.55, P=0.60) or overall @entity2 (HR=0.85, P=0.58). Significant pre-treatment predictors of severe @entity2 were a diagnosis other than @entity3 (HR=4.68, P<0.001), immunoglobulin (Ig) G levels <7g/L (HR=2.36, P=0.01), age (HR=1.03, P=0.01), and @entity1 (HR=3.61, P=0.01). CONCLUSIONS: Low B-cell counts before RTX infusion did not predict subsequent @entity2 in this population treated with RTX for @entity3 and other @entity4 , therefore not supporting the practice of pre-treatment assessment of B-cells. Nevertheless, a higher risk of severe @entity2 was confirmed for low pre-treatment IgG levels, older age, @entity1 , and @entity4 other than @entity3 .

title: Low pre-treatment B-cell counts are not a risk factor of @entity2 in @entity0 treated with rituximab for XXXX : An observational study.

answer: @entity4


abstract: OBJECTIVES: Rituximab (RTX) is increasingly used in @entity0 with @entity3 ( @entity3 ) and other severe @entity4 ( @entity4 ). In practice, many clinicians are reluctant to prescribe RTX in @entity0 with low B-cell counts because of the presumed risk of @entity2 . The aim of this study was therefore to investigate whether B-cell counts before treatment or retreatment with RTX predict the occurrence of @entity2 . METHODS: Observational, single-centre study of 161 @entity0 treated with RTX for @entity3 and other @entity4 at a tertiary hospital. @entity5 + B-cell counts were assessed by flow cytometry and multivariate statistical analysis adjusted for various potential predictors was performed. RESULTS: The rate of severe @entity2 was 5.9/100 @entity0 -years in @entity3 @entity0 and 24.9 in non- @entity3 @entity4 (P<0.001). Low B-cell counts at the time of RTX infusion were not associated with subsequent severe (HR=0.55, P=0.60) or overall @entity2 (HR=0.85, P=0.58). Significant pre-treatment predictors of severe @entity2 were a diagnosis other than @entity3 (HR=4.68, P<0.001), immunoglobulin (Ig) G levels <7g/L (HR=2.36, P=0.01), age (HR=1.03, P=0.01), and @entity1 (HR=3.61, P=0.01). CONCLUSIONS: Low B-cell counts before RTX infusion did not predict subsequent @entity2 in this population treated with RTX for @entity3 and other @entity4 , therefore not supporting the practice of pre-treatment assessment of B-cells. Nevertheless, a higher risk of severe @entity2 was confirmed for low pre-treatment IgG levels, older age, @entity1 , and @entity4 other than @entity3 .

title: Low pre-treatment B-cell counts are not a risk factor of XXXX in @entity0 treated with rituximab for @entity4 : An observational study.

answer: @entity2


abstract: OBJECTIVES: Rituximab (RTX) is increasingly used in @entity0 with @entity3 ( @entity3 ) and other severe @entity4 ( @entity4 ). In practice, many clinicians are reluctant to prescribe RTX in @entity0 with low B-cell counts because of the presumed risk of @entity2 . The aim of this study was therefore to investigate whether B-cell counts before treatment or retreatment with RTX predict the occurrence of @entity2 . METHODS: Observational, single-centre study of 161 @entity0 treated with RTX for @entity3 and other @entity4 at a tertiary hospital. @entity5 + B-cell counts were assessed by flow cytometry and multivariate statistical analysis adjusted for various potential predictors was performed. RESULTS: The rate of severe @entity2 was 5.9/100 @entity0 -years in @entity3 @entity0 and 24.9 in non- @entity3 @entity4 (P<0.001). Low B-cell counts at the time of RTX infusion were not associated with subsequent severe (HR=0.55, P=0.60) or overall @entity2 (HR=0.85, P=0.58). Significant pre-treatment predictors of severe @entity2 were a diagnosis other than @entity3 (HR=4.68, P<0.001), immunoglobulin (Ig) G levels <7g/L (HR=2.36, P=0.01), age (HR=1.03, P=0.01), and @entity1 (HR=3.61, P=0.01). CONCLUSIONS: Low B-cell counts before RTX infusion did not predict subsequent @entity2 in this population treated with RTX for @entity3 and other @entity4 , therefore not supporting the practice of pre-treatment assessment of B-cells. Nevertheless, a higher risk of severe @entity2 was confirmed for low pre-treatment IgG levels, older age, @entity1 , and @entity4 other than @entity3 .

title: Low pre-treatment B-cell counts are not a risk factor of @entity2 in XXXX treated with rituximab for @entity4 : An observational study.

answer: @entity0


abstract: OBJECTIVE: In @entity7 ( @entity7 ), replacement with @entity4 may result in lower @entity1 ( @entity1 ) compared with @entity5 therapy. However, the number of @entity0 studied on @entity4 is small and the results are conflicting. We conducted a cross-sectional study to determine @entity1 and its relation with therapy in @entity0 on physiologic doses of @entity4 replacement. METHODS: Forty-one consecutive @entity0 (31 males, age [mean    SD] 50.9    13.0 years), receiving @entity4 ( @entity5 equivalent [HCE] 13.0    3.0 mg/m(2)) for 104    95 months were studied. @entity1 was evaluated by dual-energy X-ray absorptiometry and compared with an age- and sex-matched reference group of healthy Indian subjects (n = 677). RESULTS: Among males, @entity1 Z-scores (mean [95% confidence interval {CI}]) at lumbar spine (-0.42 [-0.80, -0.04]), femoral neck (-0.50 [-0.95, -0.06]) and total hip (-0.58 [-0.90, -0.26]) were significantly lower than the reference population. Z-scores in female @entity0 did not differ from controls. Among postmenopausal females and males >50 years, 43% had @entity2 (T-score  <=-2.5), as compared with 25% in the reference group (P = .04). There was no correlation between @entity1 Z-scores and HCE dose or duration of therapy. On multivariate regression analysis, body mass index was the only significant predictor of @entity1 . A high proportion of males (45%) had low serum @entity3 (<300 ng/dL), but there was no correlation between @entity3 and @entity1 . CONCLUSIONS: Male @entity0 with @entity7 receiving physiologic @entity4 replacement had a small but significant diminution in @entity1 at all sites. ABBREVIATIONS: ACTH = adrenocorticotropic hormone BAP = bone-specific alkaline phosphatase @entity1 = @entity1 BMI = body mass index CI = confidence interval HCE = @entity5 equivalent 25 ( @entity6 ) D3 = @entity8 @entity7 = @entity7 .

title: BONE MINERAL DENSITY IN @entity0 WITH ADDISON DISEASE ON REPLACEMENT THERAPY WITH XXXX .

answer: @entity4


abstract: OBJECTIVE: In @entity7 ( @entity7 ), replacement with @entity4 may result in lower @entity1 ( @entity1 ) compared with @entity5 therapy. However, the number of @entity0 studied on @entity4 is small and the results are conflicting. We conducted a cross-sectional study to determine @entity1 and its relation with therapy in @entity0 on physiologic doses of @entity4 replacement. METHODS: Forty-one consecutive @entity0 (31 males, age [mean    SD] 50.9    13.0 years), receiving @entity4 ( @entity5 equivalent [HCE] 13.0    3.0 mg/m(2)) for 104    95 months were studied. @entity1 was evaluated by dual-energy X-ray absorptiometry and compared with an age- and sex-matched reference group of healthy Indian subjects (n = 677). RESULTS: Among males, @entity1 Z-scores (mean [95% confidence interval {CI}]) at lumbar spine (-0.42 [-0.80, -0.04]), femoral neck (-0.50 [-0.95, -0.06]) and total hip (-0.58 [-0.90, -0.26]) were significantly lower than the reference population. Z-scores in female @entity0 did not differ from controls. Among postmenopausal females and males >50 years, 43% had @entity2 (T-score  <=-2.5), as compared with 25% in the reference group (P = .04). There was no correlation between @entity1 Z-scores and HCE dose or duration of therapy. On multivariate regression analysis, body mass index was the only significant predictor of @entity1 . A high proportion of males (45%) had low serum @entity3 (<300 ng/dL), but there was no correlation between @entity3 and @entity1 . CONCLUSIONS: Male @entity0 with @entity7 receiving physiologic @entity4 replacement had a small but significant diminution in @entity1 at all sites. ABBREVIATIONS: ACTH = adrenocorticotropic hormone BAP = bone-specific alkaline phosphatase @entity1 = @entity1 BMI = body mass index CI = confidence interval HCE = @entity5 equivalent 25 ( @entity6 ) D3 = @entity8 @entity7 = @entity7 .

title: BONE MINERAL DENSITY IN XXXX WITH ADDISON DISEASE ON REPLACEMENT THERAPY WITH @entity4 .

answer: @entity0


abstract: STUDY OBJECTIVES: To evaluate the diagnostic accuracy and outcomes for @entity0 treated by use of a prehospital @entity1 protocol (CPP). DESIGN: Consecutive case series for 1 year (1993) of prehospital nontrauma @entity6 ( @entity6 ) cases including hospital outcomes. SETTING: Nonurban two-tiered emergency medical services system. @entity0 : @entity0 treated under the prehospital CPP or with hospital diagnoses of @entity2 ( @entity2 ; ICD-9 between 410 and 414). @entity0 with @entity4 or @entity3 were excluded. INTERVENTIONS: @entity0 were given, by standing orders, ECG monitoring, i.v. access, and sublingual @entity5 . Further therapy was guided by on-line medical direction. RESULTS: Of 3,122 @entity6 nontrauma @entity0 , 620 (20%) were treated with the CPP. All @entity0 underwent ECG monitoring, i.v. access was started in 83%, and 61% received @entity5 . Only 55% of @entity0 completed the entire CPP; @entity0 who failed to complete the CPP had the same prevalence of @entity2 as those who completed it. When compared with hospital diagnosis of @entity2 , the CPP had a sensitivity of 69% (95% confidence interval [CI], 64% to 74%), a specificity of 87% (95% CI, 86% to 88%), and a positive predictive value of 42%. The positive likelihood ratio of CPP for @entity2 was 5.31, and the negative likelihood ratio was .36. The hospital mortality rate for all @entity0 was 2.2%; for those with @entity2 , it was 1.6%. CONCLUSION: This prehospital @entity6 CPP had good diagnostic accuracy, but only half of @entity0 completed it, and the hospital mortality rate was low. These data challenge the efficacy of the CPP.

title: Evaluation of a prehospital XXXX protocol.

answer: @entity1


abstract: STUDY OBJECTIVE: To evaluate the effect of an outbreak of @entity2 O157:H7 @entity3 , and media coverage of the outbreak, on use of an emergency department. DESIGN: Review of pediatric @entity4 use and charges for @entity1 during the epidemic and during a control period. SETTING: Pediatric @entity4 in Seattle, Washington. @entity0 : All @entity0 seen in the @entity4 with a @entity1 during the epidemic period (January and February 1993) and during a control period (January and February 1992). RESULTS: During the epidemic, 31 @entity0 with @entity2 O157:H7 infection had 45 visits to the @entity4 . The number of visits for @entity1 not caused by @entity2 O157:H7 was 103% higher in the epidemic period than in the control period (653 in 1992, 1,327 in 1993). The number of visits was closely associated with the number of newspaper stories about @entity2 O157:H7 illness (correlation coefficient, .88; P = .002). The increased number of evaluations for @entity1 not caused by @entity2 O157:H7 infection during the epidemic period was associated with an additional  101,193 in charges per month compared with the control period. There were no important differences in the evaluation of @entity1 between 1992 and 1993 except for an increase in the proportion of @entity0 with stool cultures (13.1% versus 26.4%, P < .001). CONCLUSION: For every visit by a @entity0 with @entity2 O157:H7 infection, there were 15 additional visits (above the baseline from the control period) by @entity0 with other @entity1 . The true cost of this epidemic included not only the evaluation of @entity0 with disease but also the evaluation of those who presented because they were worried they had the disease. The intensity of media coverage of a disaster may correlate with the number of visits to the @entity4 , and understanding of this fact may help in disaster planning.

title: Outbreak of XXXX O157:H7 hemorrhagic colitis and hemolytic uremic syndrome: effect on use of a pediatric emergency department.

answer: @entity2


abstract: BACKGROUND: The blood brain barrier (BBB) is critical for maintaining central nervous system (CNS) homeostasis by restricting entry of potentially toxic substances. However, the BBB is a major obstacle in the treatment of @entity2 and @entity0 due to the restrictive nature of the barrier to many medications. Intranasal delivery of active enzymes to the brain has therapeutic potential for the treatment of numerous CNS @entity5 caused by chemical threat agents. NEW METHOD: The aim of this work is to provide a sensitive model system for analyzing the rapid delivery of active enzymes into various regions of the brain with therapeutic bioavailability. RESULTS: We tested intranasal delivery of @entity3 acetyltransferase (CAT), a relatively large (75kD) enzyme, in its active form into different regions of the brain. CAT was delivered intranasally to anaesthetized @entity1 and enzyme activity was measured in different regions using a highly specific High Performance Thin Layer Chromatography (HP-TLC)-radiometry coupled assay. Active enzyme reached all examined areas of the brain within 15min (the earliest time point tested). In addition, the yield of enzyme activity in the brain was almost doubled in the brains of @entity1 pre-treated with @entity4 ( @entity4 ). COMPARISON WITH EXISTING METHOD (S): Intranasal administration of active enzymes in conjunction with @entity4 to the CNS is both rapid and effective. CONCLUSION: The present results suggest that intranasal enzyme therapy is a promising method for counteracting CNS chemical threat poisoning, as well as for treating @entity5 .

title: Rapid intranasal delivery of XXXX acetyltransferase in the active form to different brain regions as a model for enzyme therapy in the CNS.

answer: @entity3


abstract: OBJECTIVE: To evaluate the risk of @entity2 associated with starting @entity5 ( @entity5 ) after acute @entity4 ( @entity4 ) and to examine the frequency of @entity3 . @entity0 AND METHODS: We retrospectively identified all @entity0 admitted to our institution with @entity4 that received @entity5 during their initial hospitalization over a three-year period. We reviewed their demographics, hospital course, clinical indication and timing for initiation of @entity5 , and complications. RESULTS: A total of 222 @entity0 were identified. The median age and Injury Severity Score (ISS) was 61 and 21, respectively. Fifty (23%) @entity0 required neurosurgical procedures. APTs were initiated due to a history of @entity5 use in 91 @entity0 (41%) and blunt @entity1 in 86 @entity0 (38.6%). The median time from @entity5 was 4 days. Immediate complications including new or worsening @entity2 occurred in 1 (<1%) @entity0 . Delayed @entity2 occurred in 6 (4.7%) @entity0 . @entity3 events occurred in 21 (9.4%) @entity0 prior to starting @entity5 . Thirteen (5.8%) of these were potentially preventable. CONCLUSION: The risk of immediate and delayed @entity4 from initiating @entity5 after @entity4 must be weighed against the morbidity of delaying indicated @entity3 . Our initial data indicates that @entity2 are infrequent, and @entity3 can have significant clinical consequences. Our retrospective review provides the first rates of complications for this @entity0 population.

title: Use of anti-platelet agents after XXXX .

answer: @entity4


abstract: We investigated the occurrence of @entity4 and estimated predictors for risk of @entity1 among @entity0 in the Bunuso community of Ashanti Region of Ghana, West Africa. The cross-sectional survey was conducted between June and December 2009. Information was obtained on socio-demographic characteristics, @entity2 symptoms and other risk factors through interviews and questionnaires. Urine samples were analysed for @entity3 ova using centrifugation and sedimentation, filtration and microscopy. Bivariate estimations and multiple logistic regression modelling with odds ratios (OR) were used to assess risk factors for @entity3 infections. Inspections at River Nanakwaw revealed snail vectors, Bulinus truncatus. Overall, 95 out of 100 (95  % confidence interval [CI] 88.8-97.6) @entity0 tested positive for @entity3 @entity1 . The mean ova density (eggs/10  ml of urine) of infections was 58.12 (95  % CI 31.3-71.6) and varied significantly between age-group distributions (P value  =  0.001; Post Hoc, P  >  0.05 for  <=8 vs 15-17  years, and 9-11 vs 12-14  years), sources of house-hold water (P value  =  0.019; Post Hoc, P  <  0.05 for Borehole vs River Nanakwaw), @entity0 activities in River Nanakwaw (P value  =  0.001), and haematuria (P value  =  0.007). Independent variables significantly associated with @entity3 infections were the use of River Nanakwaw as source of household water (OR 12.54; 95  % CI 3.932-42.12, P value  =  0.003), engaging activities in River Nanakwaw (OR 8.76; 95  % CI 1.759-31.871; P value  =  0.008) and haematuria (OR 36.71; 95  % CI 10.18-48.47; P value  =  0.001). The passage of blood urine was prognostic of @entity4 with a positive predictive value of 97.5  %. Our results demonstrate the endemicity of @entity4 in Bunuso. Schistosomiasis remains a disease of great public health importance in Ghana, and there is the urgent need to intensify surveillance and control programs in remote riparian communities.

title: High levels of XXXX among @entity0 in Bunuso, a rural community in Ghana: an urgent call for increased surveillance and control programs.

answer: @entity4


abstract: We investigated the occurrence of @entity4 and estimated predictors for risk of @entity1 among @entity0 in the Bunuso community of Ashanti Region of Ghana, West Africa. The cross-sectional survey was conducted between June and December 2009. Information was obtained on socio-demographic characteristics, @entity2 symptoms and other risk factors through interviews and questionnaires. Urine samples were analysed for @entity3 ova using centrifugation and sedimentation, filtration and microscopy. Bivariate estimations and multiple logistic regression modelling with odds ratios (OR) were used to assess risk factors for @entity3 infections. Inspections at River Nanakwaw revealed snail vectors, Bulinus truncatus. Overall, 95 out of 100 (95  % confidence interval [CI] 88.8-97.6) @entity0 tested positive for @entity3 @entity1 . The mean ova density (eggs/10  ml of urine) of infections was 58.12 (95  % CI 31.3-71.6) and varied significantly between age-group distributions (P value  =  0.001; Post Hoc, P  >  0.05 for  <=8 vs 15-17  years, and 9-11 vs 12-14  years), sources of house-hold water (P value  =  0.019; Post Hoc, P  <  0.05 for Borehole vs River Nanakwaw), @entity0 activities in River Nanakwaw (P value  =  0.001), and haematuria (P value  =  0.007). Independent variables significantly associated with @entity3 infections were the use of River Nanakwaw as source of household water (OR 12.54; 95  % CI 3.932-42.12, P value  =  0.003), engaging activities in River Nanakwaw (OR 8.76; 95  % CI 1.759-31.871; P value  =  0.008) and haematuria (OR 36.71; 95  % CI 10.18-48.47; P value  =  0.001). The passage of blood urine was prognostic of @entity4 with a positive predictive value of 97.5  %. Our results demonstrate the endemicity of @entity4 in Bunuso. Schistosomiasis remains a disease of great public health importance in Ghana, and there is the urgent need to intensify surveillance and control programs in remote riparian communities.

title: High levels of @entity4 among XXXX in Bunuso, a rural community in Ghana: an urgent call for increased surveillance and control programs.

answer: @entity0


abstract: Hemorrhagic @entity4 ( @entity4 ) was studied after @entity7 ( @entity7 ) in 30 @entity0 undergoing autopsy. Urokinase, 240,000 to 1,200,000 U, was selectively injected into the @entity6 -related coronary artery at 2 to 9 hr (4 +/- 2 hr) after the onset of @entity4 . The @entity6 -related coronary artery showed complete occlusion in 21, 99% @entity5 in eight, and 90% @entity5 in one @entity0 before @entity7 . After @entity7 , complete occlusion was seen in only five, 99% @entity5 in 22, and 90% @entity5 in three @entity0 . Twenty-eight @entity0 had transmural @entity6 and the other two had @entity6 . Macroscopically and microscopically, the degree of @entity3 was classified as no, slight, moderate, or marked bleeding and the @entity2 was defined as moderate or marked @entity3 in the @entity6 area. According to the interval from @entity7 to @entity1 , @entity0 were also classified into stage I (early acute stage, 1 to 4 hr after @entity7 and 4 to 13 hr after the onset of @entity4 ; n = 7), stage II (late acute stage, 9 hr to 11 days after @entity7 and 15 hr to 11 days after the onset of @entity4 ; n = 18), or stage III (old @entity6 stage, over 17 days after @entity4 and @entity7 ; n = 5). There were no significant differences with respect to the frequency of recanalization, the time from the onset of @entity4 to @entity7 , the dose of urokinase, or other clinical parameters among @entity0 at the three stages. Only the hearts of @entity0 in stage II showed @entity2 , and it was found in 15 of 18 of these hearts.(ABSTRACT TRUNCATED AT 250 WORDS)

title: A clinicopathologic study of @entity0 with hemorrhagic XXXX treated with selective coronary thrombolysis with urokinase.

answer: @entity4


abstract: Hemorrhagic @entity4 ( @entity4 ) was studied after @entity7 ( @entity7 ) in 30 @entity0 undergoing autopsy. Urokinase, 240,000 to 1,200,000 U, was selectively injected into the @entity6 -related coronary artery at 2 to 9 hr (4 +/- 2 hr) after the onset of @entity4 . The @entity6 -related coronary artery showed complete occlusion in 21, 99% @entity5 in eight, and 90% @entity5 in one @entity0 before @entity7 . After @entity7 , complete occlusion was seen in only five, 99% @entity5 in 22, and 90% @entity5 in three @entity0 . Twenty-eight @entity0 had transmural @entity6 and the other two had @entity6 . Macroscopically and microscopically, the degree of @entity3 was classified as no, slight, moderate, or marked bleeding and the @entity2 was defined as moderate or marked @entity3 in the @entity6 area. According to the interval from @entity7 to @entity1 , @entity0 were also classified into stage I (early acute stage, 1 to 4 hr after @entity7 and 4 to 13 hr after the onset of @entity4 ; n = 7), stage II (late acute stage, 9 hr to 11 days after @entity7 and 15 hr to 11 days after the onset of @entity4 ; n = 18), or stage III (old @entity6 stage, over 17 days after @entity4 and @entity7 ; n = 5). There were no significant differences with respect to the frequency of recanalization, the time from the onset of @entity4 to @entity7 , the dose of urokinase, or other clinical parameters among @entity0 at the three stages. Only the hearts of @entity0 in stage II showed @entity2 , and it was found in 15 of 18 of these hearts.(ABSTRACT TRUNCATED AT 250 WORDS)

title: A clinicopathologic study of XXXX with hemorrhagic @entity4 treated with selective coronary thrombolysis with urokinase.

answer: @entity0


abstract: BACKGROUND: @entity0 form nearly 3% of @entity1 . Due to their large histological variety and @entity2 , pre-operative diagnosis and differentiation of benign and malignant @entity0 are a major challenge for radiologists. OBJECTIVE: The majority of these @entity0 are benign; however, sometimes they tend to transform into a malignant form. Functional MRI techniques, namely dynamic contrast enhanced ( @entity3 -) MRI and diffusion-weighted MRI (DWI) can indicate the characteristics of @entity0 tissue. METHODS: @entity3 -MRI analysis is based on the parameters of time intensity curve (TIC) before and after contrast agent injection. This method has the potential to identify the angiogenesis of @entity0 . DWI analysis is performed according to diffusion of water molecules in a tissue for determination of the cellularity of @entity0 . CONCLUSION: According to the literature, these methods cannot be used individually to differentiate benign from @entity0 . An effective approach could be to combine the aforementioned methods to increase the accuracy of discrimination between different @entity0 types. The main objective of this study is to explore the application of @entity3 -MRI and DWI for assessment of @entity0 types.

title: Dynamic Contrast Magnetic Resonance Imaging ( XXXX -MRI) and Diffusion Weighted MR Imaging (DWI) for Differentiation between Benign and Malignant Salivary Gland Tumors.

answer: @entity3


abstract: To assess the prevalence and significance of @entity8 in @entity0 with severe left @entity2 secondary to @entity6 (or @entity6 ), we studied 70 @entity0 with an ejection fraction of 35 percent or @entity6 (n = 14) or with multivessel @entity6 (n = 56). None had had a recent @entity7 or @entity5 . @entity0 who underwent myocardial revascularization during follow-up were excluded. The left ventricular end-diastolic volume (measured by contrast ventriculography) was less than 110 ml/sq m in 14 @entity0 (20 percent) (group 1), and was 110 ml/sq m or more in 56 @entity0 (80 percent) (group 2). There were no differences between the two groups in age, sex, @entity1 , @entity3 , extent of @entity6 , or left @entity2 . @entity0 in group 1 had lower pulmonary arterial wedge pressure (13 +/- 6 vs 22 +/- 10 mm Hg; p = 0.0008), lower left ventricular end-diastolic pressure (21 +/- 6 vs 27 +/- 9 mm Hg; p = 0.007), and higher left ventricular ejection fraction (31 +/- 2 vs 25 +/- 7 percent; p = 0.001) than @entity0 in group 2. At a mean follow-up of 27 months, 24 @entity0 had died of cardiac causes, all of whom were in group 2. Survival was significantly better in group 1 than in group 2 (Mantel-Cox, p = 0.009). Survival analysis (Cox models) of 20 clinical, hemodynamic, and angiographic variables showed that ejection fraction (chi2 = 13.6; p less than 0.001) and end-diastolic volume chi2 = 4.7; p = 0.03) were the most significant predictors of @entity4 . Thus, minimally dilated @entity6 is a distinct entity with favorable hemodynamics. Prognostically, the end-diastolic volume adds significant predictive information to the ejection fraction among conservatively treated @entity0 .

title: XXXX . Hemodynamic and prognostic implications.

answer: @entity6


abstract: This study of @entity2 in elderly (mean age 85 years, range 68 to 103) Jewish subjects of mostly middle and upper class attempted to determine disease prevalence, define the turnover in infected subjects, and assess the relation between functional status and @entity1 . The prevalence of @entity2 (midstream clean-catch method) was assessed in 373 @entity0 and 150 @entity0 . It was higher in @entity0 (18.2 percent) than in @entity0 (6.0 percent) (p less than 0.001) and was more common in functionally impaired nursing home residents (23.5 percent) than in apartment house dwellers (12.1 percent) (p less than 0.01). In longitudinal studies, 260 subjects (184 @entity0 and 76 @entity0 ) had three urine culture surveys at six-month intervals. The cumulative percent infected on at least one survey was high ( @entity0 30.4 percent, @entity0 10.5 percent). However, persistence of the same organism on all three surveys was surprisingly infrequent ( @entity0 6.0 percent, @entity0 1.3 percent), and the turnover of infected and noninfected subjects was considerable. Persistence of @entity2 on all three surveys was significantly more common in nursing home residents (13.9 percent) than in apartment house dwellers (3.1 percent) (p less than 0.01). Thus, @entity2 is common in the elderly and appears related to functional status. However, the turnover of infected and noninfected subjects was high, and surprisingly, persistence was not found in most. The transient nature of @entity2 in most provides support against the treatment of asymptomatic @entity2 in the elderly.

title: Epidemiology of XXXX in an elderly ambulatory population.

answer: @entity2


abstract: KEY POINTS: @entity2 receptor heteromerization and auxiliary subunits, @entity6 and @entity7 , attenuate @entity4 ion-channel block by facilitating blocker permeation. Relief of @entity4 block in @entity1 / @entity5 heteromers results from a key @entity0 residue that produces architectural changes in the channel pore a-helical region. Auxiliary subunits exert an additive effect to heteromerization, and thus relief of @entity4 block is due to a different mechanism. Our findings have broad implications for work on @entity4 block of other cation-selective ion channels. ABSTRACT: Channel block and permeation by cytoplasmic @entity3 is a common feature of many cation-selective ion channels. Although the channel block mechanism has been studied extensively, @entity4 permeation has been considered less significant as it occurs at extreme positive membrane potentials. Here, we show that @entity2 receptor (KAR) heteromerization and association with auxiliary proteins, @entity6 and @entity7 , attenuate @entity4 block by enhancing blocker permeation. Consequently, @entity4 permeation and unblock occur at more negative and physiologically relevant membrane potentials. In @entity1 / @entity5 heteromers, enhanced permeation is due to a single @entity0 residue in @entity5 that alters the dynamics of the a-helical region of the selectivity filter. The effect of auxiliary proteins is additive, and therefore the structural basis of @entity4 permeation and unblock is through a different mechanism. As native receptors are thought to assemble as heteromers in complex with auxiliary proteins, our data identify an unappreciated impact of @entity4 permeation in shaping the signalling properties of neuronal KARs and point to a structural mechanism that may be shared amongst other cation-selective ion channels.

title: XXXX receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism.

answer: @entity2


abstract: OBJECTIVES: To determine the proportion of @entity0 with @entity2 ( @entity2 ) who had a cerebrospinal fluid (CSF) pressure >6   cm @entity1 and to investigate the clinical and imaging variables associated with CSF pressure (PCSF) in this condition. METHODS: We retrospectively reviewed 106 @entity0 with @entity2 . PCSF was measured by lumbar puncture prior to treatment. Clinical and imaging variables - including demographic data, brain imaging results, symptom duration, and abdominal circumference - were collected. Univariate and multivariate analyses were performed to determine the correlation of these variables with PCSF. RESULTS: Sixty-one percent of @entity0 had a PCSF between 6 and 20   cm @entity1 ; only 34% had a PCSF  <=6   cm @entity1 . The factors associated with increased PCSF included abdominal circumference (p   <   0.001), symptom duration (p   =   0.015), and the absence of brain magnetic resonance imaging findings of @entity2 (p   =   0.003). A wide variability in PCSF was observed among all @entity0 , which was not completely accounted for by the variables included in the model. CONCLUSIONS: Normal CSF pressure is common in @entity0 with @entity2 ; the absence of a low opening pressure should not exclude this condition. Body habitus, symptom duration, and brain imaging are correlated with PCSF measurements, but these factors alone do not entirely explain the wide variability in observed pressures in this condition and this suggests the influence of other factors.

title: How common is normal cerebrospinal fluid pressure in XXXX ?

answer: @entity2


abstract: OBJECTIVE: To investigate the significance of @entity2 in @entity3 and its relation both to maximum @entity1 consumption during cardiopulmonary exercise testing and to skeletal muscle (quadriceps) strength. SUBJECTS: Seven healthy @entity0 aged 54.9 (SEM 4.3) years and 20 @entity0 with @entity3 aged 61.4 (1.6) years (P = 0.20) with radionuclide left ventricular ejection fraction of 25.4 (3.0)%. METHODS: Mouth pressures during maximum static inspiratory effort (PImax) at functional residual capacity (FRC) and residual volume (RV) were measured in all subjects and taken as indices of inspiratory muscle strength. Similarly, mouth pressures during maximum static expiratory effort (PEmax) at FRC and total lung capacity (TLC) were taken as indices of expiratory muscle strength. Cardiopulmonary exercise testing was performed in all subjects. All controls and 15 @entity3 @entity0 also had their right quadriceps muscle strength measured. RESULTS: There was @entity2 in @entity3 @entity0 , with reduction of PImax at FRC (59.7) (6.3) v 85.6 (9.6) cm @entity4 , P = 0.045), PEmax at FRC (94.8 (6.2) v 134.6 (9.1) cm @entity4 , P = 0.004), and PEmax at TLC (121.7 (8.5) v 160.7 (13) cm @entity4 , P = 0.028). PImax at RV was also reduced but this did not reach statistical significance (77.3 (6.6) v 89.3 (13) cm @entity4 , P = 0.44). There was also significant @entity2 (308.5 (22) v 446.2 (28) N, P = 0.001). PImax at both FRC and RV correlated with maximum @entity1 consumption (r = 0.59, P = 0.006, and r = 0.45, P = 0.048 respectively) but not PEmax. There was, however, no significant correlation between PImax and right quadriceps strength. CONCLUSIONS: Respiratory @entity2 is seen in @entity3 . The results suggest that inspiratory muscles are important in determining maximum @entity1 consumption and exercise tolerance in these @entity0 . The lack of correlation between respiratory and right quadriceps muscle strength further suggests that the magnitude and time course of @entity2 may differ in individual @entity0 . Treatment aimed at improving the function of the involved muscle groups may alleviate symptoms.

title: Inspiratory muscle strength is a determinant of maximum XXXX consumption in @entity3 .

answer: @entity1


abstract: OBJECTIVE: To investigate the significance of @entity2 in @entity3 and its relation both to maximum @entity1 consumption during cardiopulmonary exercise testing and to skeletal muscle (quadriceps) strength. SUBJECTS: Seven healthy @entity0 aged 54.9 (SEM 4.3) years and 20 @entity0 with @entity3 aged 61.4 (1.6) years (P = 0.20) with radionuclide left ventricular ejection fraction of 25.4 (3.0)%. METHODS: Mouth pressures during maximum static inspiratory effort (PImax) at functional residual capacity (FRC) and residual volume (RV) were measured in all subjects and taken as indices of inspiratory muscle strength. Similarly, mouth pressures during maximum static expiratory effort (PEmax) at FRC and total lung capacity (TLC) were taken as indices of expiratory muscle strength. Cardiopulmonary exercise testing was performed in all subjects. All controls and 15 @entity3 @entity0 also had their right quadriceps muscle strength measured. RESULTS: There was @entity2 in @entity3 @entity0 , with reduction of PImax at FRC (59.7) (6.3) v 85.6 (9.6) cm @entity4 , P = 0.045), PEmax at FRC (94.8 (6.2) v 134.6 (9.1) cm @entity4 , P = 0.004), and PEmax at TLC (121.7 (8.5) v 160.7 (13) cm @entity4 , P = 0.028). PImax at RV was also reduced but this did not reach statistical significance (77.3 (6.6) v 89.3 (13) cm @entity4 , P = 0.44). There was also significant @entity2 (308.5 (22) v 446.2 (28) N, P = 0.001). PImax at both FRC and RV correlated with maximum @entity1 consumption (r = 0.59, P = 0.006, and r = 0.45, P = 0.048 respectively) but not PEmax. There was, however, no significant correlation between PImax and right quadriceps strength. CONCLUSIONS: Respiratory @entity2 is seen in @entity3 . The results suggest that inspiratory muscles are important in determining maximum @entity1 consumption and exercise tolerance in these @entity0 . The lack of correlation between respiratory and right quadriceps muscle strength further suggests that the magnitude and time course of @entity2 may differ in individual @entity0 . Treatment aimed at improving the function of the involved muscle groups may alleviate symptoms.

title: Inspiratory muscle strength is a determinant of maximum @entity1 consumption in XXXX .

answer: @entity3


abstract: A large, heavily populated area regionalized the care of critical @entity1 in 1980. To evaluate the system, we reviewed @entity0 outcome for thoracic aortic transection due to @entity5 for the first 18 months of @entity1 system operation. Of the total of 86 @entity0 , 43 were transferred to @entity1 centers, 8 to nontrauma centers, and 35 were either directly transported to the coroner or dead on arrival at the hospital. Of the eight @entity0 transported to non- @entity1 centers, seven were in @entity3 during transport and the eighth was pronounced dead shortly after admission to the emergency department. Twenty-seven of the 43 @entity0 transferred to @entity1 centers were dead within 24 minutes of admission. The cause of @entity2 was rupture of a transected aorta in 22 @entity0 and other @entity4 in the remaining 5. Sixteen were alive long enough in the emergency department for evaluation. Nine of these @entity0 underwent correction of aortic transection as well as other injuries and all survived. Two of the nine survivors sustained partial or complete spinal cord damage. The remaining seven @entity0 died, but in only one @entity0 did the undiagnosed @entity1 contribute to the cause of @entity2 . This @entity0 had a normal cineangiogram and the diagnosis was made at autopsy. He was considered potentially salvageable, so 9 of 10 potentially salvageable @entity0 survived (90 percent). Of the total of 86 @entity0 with aortic transection, 77 died (90 percent). This study shows that regionalization of @entity1 care offers an excellent chance for survival of @entity0 with thoracic aortic transection.

title: Transection of the thoracic aorta: assessment of a XXXX system.

answer: @entity1


abstract: The authors in the introduction provide an schematic historical scope of reference about the spaniard and european psychiatry from the XVIIIe to the XIXe century. They described the first seven clinical cases of @entity5 found by them and published by spaniard physicians in the first half of the XIXe century. They revised mainly the clinical sintomatology, course and evolution, and went into deep detail in the hygienic-dietetical and pharmacological therapeutics used in this period, specially several galenic preparations of opium, tartarus emeticus, cremor, etc. Serapio Escolar y Morales (1808-1874) described the first clinical case of @entity7 in 1839 in a 28 year old @entity0 , raising the differential diagnosis between intermittent fever, @entity2 and @entity4 , and proposed a useless antiflogistic treatment ( @entity3 , leeches, poultice) and opium. The second case was described by an anonymous author (J.M.S.Z.) in 1845 in a 42 year old @entity0 . Francisco Castellvi y Pallares (1812-1879), in 1845, published another case in a 34 year old male, with an adequate description of the natural history of the disease, healing in 19 days with high doses of watery opium extract. The fourth clinical case was described by R.C.B. in 1846 in a 60 year old @entity0 with "alcoholic @entity6 ", " @entity1 " being the only one with a mortal outcome, treated also with opiates which he did not agree with. The fifth and sixth cases were published by Uliberry in 1847 in two males, 38 and 36 years old respectively. The seventh and last case was described in 1848 by F. Paula Barea, having to highlight the nosological, nosographical and evolutive perspectives in 3 clinical periods and a fourth of convalescence, the treatment differences and the etiopathogenical considerations. Included are 9 tables, 2 graphics and 29 bibliographical references.

title: [Historical study of seven cases of delirium XXXX in Spain in the first half of the XIX century].

answer: @entity7


abstract: Complementary DNAs for @entity4 type 1 receptor isoforms AT1A and AT1B were cloned by expression cloning from @entity2 adrenal and @entity1 vascular smooth muscles. @entity0 @entity5 receptor was also cloned. Seven transmembrane structures emerged. The @entity5 type receptor interacted with more than one type of G-proteins. The ligand binding site of @entity5 involving @entity3 167, Lys199, and @entity7 263 has been identified by site directed mutagenesis. The regulation of the receptors occur at many stages. The isoform, @entity10 , was also expression cloned from @entity1 @entity6 cells. Although its ligand binding is not affected by stable @entity8 analogs, it is a seven transmembrane domain receptor. It mediates the modulations of @entity9 phosphatase by @entity4 and @entity10 specific @entity11 . The modulation was abolished by pertussis toxin. Thus, @entity10 belongs to a new class of angiotensin receptors with unique signalling and regulatory mechanisms. @entity5 mediates cellular growth. Interestingly, @entity10 expression is inversely related to the mitogenic activity of cells.

title: Cloning, expression and regulation of XXXX receptors.

answer: @entity4


abstract: OBJECTIVE: A previous study suggested that temporary occlusion of a segment of the hepatic vein causes an increase in arterial flow and retrograde portal flow in the occluded segment. Such occlusions might improve the efficacy of arterial infusion therapy. Accordingly, we studied the change in blood flow visible on hepatic arteriograms when a segment of the hepatic vein is temporarily occluded in @entity0 with @entity2 . MATERIALS AND METHODS: The study group consisted of 24 @entity0 with nodular-type @entity2 . Conventional hepatic arteriography was followed by hepatic arteriography performed using a balloon catheter to occlude the hepatic vein that was most closely associated with the @entity1 . Visualization of the @entity1 -draining veins, portal vein branches, the degree of @entity1 vascularity, and the density of the hepatogram on the hepatic arteriogram were retrospectively compared before and during @entity3 . The veins were evaluated visually; an increase of @entity1 vascularity was defined as an increase in the number of countable @entity1 vessels during occlusion, and a dense hepatogram was considered to be a definite sinusoidgram induced by @entity3 . RESULTS: Conventional hepatic arteriography showed the @entity1 -draining veins to be branches of the portal vein in only two of the 24 @entity0 (8%). Hepatic arteriography during @entity3 , however, showed the @entity1 -draining veins to be branches of the portal vein in four of the @entity0 (17%). An increase in the degree of @entity1 vascularity with @entity3 was observed only in a @entity0 with an initial arteriohepatic vein shunt. Dense hepatogram and hepatofugal opacification of the portal vein branches in the occluded, @entity1 -bearing segment were obtained in 10 @entity0 (42%). Eight of these did not have @entity4 , whereas all of the remaining 14 @entity0 did (p < .001). CONCLUSION: Our results suggest that occlusion of a segment of the hepatic vein may be useful during arterial infusion of @entity2 .

title: Hepatic arteriography in @entity0 with XXXX : change in findings caused by balloon occlusion of tumor-draining hepatic veins.

answer: @entity2


abstract: OBJECTIVE: A previous study suggested that temporary occlusion of a segment of the hepatic vein causes an increase in arterial flow and retrograde portal flow in the occluded segment. Such occlusions might improve the efficacy of arterial infusion therapy. Accordingly, we studied the change in blood flow visible on hepatic arteriograms when a segment of the hepatic vein is temporarily occluded in @entity0 with @entity2 . MATERIALS AND METHODS: The study group consisted of 24 @entity0 with nodular-type @entity2 . Conventional hepatic arteriography was followed by hepatic arteriography performed using a balloon catheter to occlude the hepatic vein that was most closely associated with the @entity1 . Visualization of the @entity1 -draining veins, portal vein branches, the degree of @entity1 vascularity, and the density of the hepatogram on the hepatic arteriogram were retrospectively compared before and during @entity3 . The veins were evaluated visually; an increase of @entity1 vascularity was defined as an increase in the number of countable @entity1 vessels during occlusion, and a dense hepatogram was considered to be a definite sinusoidgram induced by @entity3 . RESULTS: Conventional hepatic arteriography showed the @entity1 -draining veins to be branches of the portal vein in only two of the 24 @entity0 (8%). Hepatic arteriography during @entity3 , however, showed the @entity1 -draining veins to be branches of the portal vein in four of the @entity0 (17%). An increase in the degree of @entity1 vascularity with @entity3 was observed only in a @entity0 with an initial arteriohepatic vein shunt. Dense hepatogram and hepatofugal opacification of the portal vein branches in the occluded, @entity1 -bearing segment were obtained in 10 @entity0 (42%). Eight of these did not have @entity4 , whereas all of the remaining 14 @entity0 did (p < .001). CONCLUSION: Our results suggest that occlusion of a segment of the hepatic vein may be useful during arterial infusion of @entity2 .

title: Hepatic arteriography in XXXX with @entity2 : change in findings caused by balloon occlusion of tumor-draining hepatic veins.

answer: @entity0


abstract: UNASSIGNED: @entity3 -based herbicides are among the most used pesticides worldwide. Reviews on the safety of @entity3 have been conducted by several regulatory agencies and researches centers, many times with contradictory results. This study is a systematic meta-analytical review of experimental studies on the relationship between exposure to the @entity3 ( @entity1 ) and its formulations with the formation of @entity2 ( @entity2 ) to establish a quantitative estimate of the environmental risks. The natural logarithm (ln) of the estimated response ratio was calculated from 81 experiments. A meta-analysis was performed on the complete data set, and individual meta-analyses were conducted after stratification by test system, class of vertebrate, exposure route, gender, endpoints, type of literature, formulation, @entity1 dose and exposure time. A forest plot showed an overall positive association between @entity1 exposure and its formulations and @entity2 , corroborated by the cumulative effects size. Different responses were observed on @entity0 and non- @entity0 . Interesting results was noticed in exposure route where oral administration of @entity1 presented no significance. Exposure by intraperitoneal injection presented the highest @entity2 formation. Pure @entity1 caused fewer effects than to commercial mixtures, but both presented mutagenic effects. The studies with males presented significant responses, while studies with females were not significant. The cumulative effects size was not clearly related to @entity1 dose, and was negatively related to exposure time. It can be attributed to different test systems, exposure routes and protocols analyzed. In conclusion, our results support the hypothesis that exposure to @entity1 and its formulations increases the frequency of @entity2 formation.

title: Does exposure to XXXX lead to an increase in the @entity2 frequency? A systematic and meta-analytic review.

answer: @entity3


abstract: UNASSIGNED: @entity3 -based herbicides are among the most used pesticides worldwide. Reviews on the safety of @entity3 have been conducted by several regulatory agencies and researches centers, many times with contradictory results. This study is a systematic meta-analytical review of experimental studies on the relationship between exposure to the @entity3 ( @entity1 ) and its formulations with the formation of @entity2 ( @entity2 ) to establish a quantitative estimate of the environmental risks. The natural logarithm (ln) of the estimated response ratio was calculated from 81 experiments. A meta-analysis was performed on the complete data set, and individual meta-analyses were conducted after stratification by test system, class of vertebrate, exposure route, gender, endpoints, type of literature, formulation, @entity1 dose and exposure time. A forest plot showed an overall positive association between @entity1 exposure and its formulations and @entity2 , corroborated by the cumulative effects size. Different responses were observed on @entity0 and non- @entity0 . Interesting results was noticed in exposure route where oral administration of @entity1 presented no significance. Exposure by intraperitoneal injection presented the highest @entity2 formation. Pure @entity1 caused fewer effects than to commercial mixtures, but both presented mutagenic effects. The studies with males presented significant responses, while studies with females were not significant. The cumulative effects size was not clearly related to @entity1 dose, and was negatively related to exposure time. It can be attributed to different test systems, exposure routes and protocols analyzed. In conclusion, our results support the hypothesis that exposure to @entity1 and its formulations increases the frequency of @entity2 formation.

title: Does exposure to @entity3 lead to an increase in the XXXX frequency? A systematic and meta-analytic review.

answer: @entity2


abstract: A series of 52 consecutive @entity0 with newly diagnosed @entity4 ( @entity4 ) was investigated for the presence of serum and urine monoclonal immunoglobulins. The overall incidence of @entity3 ( @entity3 ) was 69%. Serum M components belonging to the IgG and IgM classes were found in 27% of cases with a concentration ranging from 1.7 to 40.3 g/l (mean 10 g/l). A monoclonal free light chain, i.e. Bence Jones protein (BJP), was documented in the urine of 65% of cases. In 42% of the 52 @entity0 the urinary excretion of BJP represented the sole detectable monoclonal immunoglobulin abnormality. The occurrence of serum monoclonal immunoglobulins was not found to correlate with the stage or progression of the disease. Conversely, the isolated urinary excretion of BJP showed a relationship with the @entity1 load, as evaluated in terms of clinical enlargement of lymphoid areas. The presence of BJP alone was also a major distinctive feature of @entity0 with @entity2 . These preliminary data would suggest that the isolated urinary excretion of BJP may represent a parameter of clinical significance in evaluating @entity0 with @entity4 .

title: Monoclonal Bence Jones proteinuria in XXXX .

answer: @entity4


abstract: Now that the radical treatment of the @entity4 is established, it is essential to evaluate the prognosis of this condition accurately. Initiation of @entity2 is one of the factors which influence the prognosis. The aim of this study was to compare the results of electrophysiological studies performed by the endocavitary and transoesophageal approaches in the measurement of the initiation of @entity2 . Twenty-six @entity0 with a patent @entity4 were studied by the two methods with a similar protocol: incremental atrial pacing to the Wenckebach point, programmed atrial stimulation using up to two extrastimuli, repeated with an infusion of 20 to 30 ug of @entity3 . Sixteen @entity0 had reciprocating @entity1 or were asymptomatic (group I) and the other 10 had spontaneous @entity2 (group II). In group I, @entity2 was induced in 9 cases (56%) by the endocavitary and in two cases (12.5%) by the transoesophageal method. In group II, spontaneous @entity2 was reproduced in all cases by the endocavitary and transoesophageal protocols. None of the @entity0 in group I developed @entity2 during follow-up (average 2 years +/- 9 months). The authors observe that all spontaneous @entity2 of the @entity4 can be triggered by oesophageal stimulation. The prevalence of @entity2 was overestimated by endocavitary studies in asymptomatic or paucisymptomatic @entity0 . The assessment of atrial vulnerability of a @entity4 may therefore be performed by transoesophageal electro-physiological studies.

title: [Is the transesophageal approach preferable to endocavitary approach in the evaluation of XXXX ?].

answer: @entity4


abstract: Many techniques have been proposed for the treatment of @entity5 over the last 35 years: myotomy, septal myotomy-myectomy, isolated mitral valve replacement with a low profile prosthesis, cardiac transplantation. Usually, the @entity0 referred for surgery are those who do not respond or are resistant to medical therapy ( @entity0 in NYHA classes III or IV). The usual indication for myomectomy is a significant subaortic gradient and major @entity6 (> 18 mm). When @entity2 is severe or organic, mitral valve replacement is associated. When @entity6 is moderate (< 18 mm) or not evenly distributed, or after ineffective myomectomy, mitral valve replacement may be proposed. Cardiac transplantation is only considered when all medical and surgical possibilities have been exhausted. Analysis of the results of surgery (over 1,000 published cases) is hindered by the variability of the techniques employed, the indications and experience of the different groups. The operative mortality has significantly decreased (25% in the 1960s to 2 to 11% at present). The complications of myomectomy are mainly postoperative @entity7 and @entity3 , some of which require implantation of a pacemaker. Peroperative transoesophageal echocardiography could help to reduce the operative risk even further. Surgery improves symptoms and increases exercise capacity. The benefits seem greater, more frequent and longer lasting than with medical therapy. Surgery should not, however, be considered to be curative as some @entity0 remain at risk of developing symptoms related to physiopathological phenomena other than intraventricular obstruction (poor left ventricular filling, @entity1 , @entity4 ). Although some workers suggest improved survival, there have been no controlled trials on this subject.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Surgical treatment of XXXX ; techniques, indications and results].

answer: @entity5


abstract: PURPOSE: To evaluate the medium-term efficacy and safety of transobturator four-arm @entity4 mesh in the treatment of high-stage anterior @entity3 and concomitant stress @entity1 (SUI). MATERIALS AND METHODS: Between September 2010 and August 2013, a prospective single-center trial was performed to evaluate @entity0 with stage>= 3 anterior @entity3 with or without SUI who presented to Labbafinejad Hospital, Teheran, Iran, and underwent anterior vaginal wall repair with @entity4 mesh. Pre- and postoperative evaluation included history; physical examination using the Pelvic Organ Prolapse Quantification system and cough stress test, both before and after reduction of prolapsed structures; Pelvic Floor Distress Inventory (PFDI) and Pelvic Floor Impact Questionnaire (PFIQ); urinalysis and culture; and a postvoid residual assessment. Complications were reported at a mean of 2 years of follow-up. RESULTS: A total of 71 @entity0 underwent cystocele repair with the transobturator four-arm @entity4 mesh. Seven of the @entity0 were lost to follow-up. There were no perioperative complications. The anatomical success rate was 87.5%. The subjective success rate was 92.1%. The PFDI and PFIQ were significantly improved after surgery (p<0.001). Among those with the simultaneous complaint of SUI, 82% were cured without any additional procedure. Three @entity0 (4.6%) experienced vaginal mesh extrusion. Two @entity0 (3.1%) reported worsening of @entity2 after surgery. CONCLUSIONS: The four arms @entity4 mesh is an effective device for simultaneous correction of anterior @entity3 and SUI with a low complication rate at a medium-term follow-up. The majority of the subgroup with concomitant SUI were cured without a second simultaneous procedure.

title: Simultaneous treatment of anterior XXXX and stress @entity1 by using transobturator four arms @entity4 mesh.

answer: @entity3


abstract: PURPOSE: To evaluate the medium-term efficacy and safety of transobturator four-arm @entity4 mesh in the treatment of high-stage anterior @entity3 and concomitant stress @entity1 (SUI). MATERIALS AND METHODS: Between September 2010 and August 2013, a prospective single-center trial was performed to evaluate @entity0 with stage>= 3 anterior @entity3 with or without SUI who presented to Labbafinejad Hospital, Teheran, Iran, and underwent anterior vaginal wall repair with @entity4 mesh. Pre- and postoperative evaluation included history; physical examination using the Pelvic Organ Prolapse Quantification system and cough stress test, both before and after reduction of prolapsed structures; Pelvic Floor Distress Inventory (PFDI) and Pelvic Floor Impact Questionnaire (PFIQ); urinalysis and culture; and a postvoid residual assessment. Complications were reported at a mean of 2 years of follow-up. RESULTS: A total of 71 @entity0 underwent cystocele repair with the transobturator four-arm @entity4 mesh. Seven of the @entity0 were lost to follow-up. There were no perioperative complications. The anatomical success rate was 87.5%. The subjective success rate was 92.1%. The PFDI and PFIQ were significantly improved after surgery (p<0.001). Among those with the simultaneous complaint of SUI, 82% were cured without any additional procedure. Three @entity0 (4.6%) experienced vaginal mesh extrusion. Two @entity0 (3.1%) reported worsening of @entity2 after surgery. CONCLUSIONS: The four arms @entity4 mesh is an effective device for simultaneous correction of anterior @entity3 and SUI with a low complication rate at a medium-term follow-up. The majority of the subgroup with concomitant SUI were cured without a second simultaneous procedure.

title: Simultaneous treatment of anterior @entity3 and stress XXXX by using transobturator four arms @entity4 mesh.

answer: @entity1


abstract: PURPOSE: To evaluate the medium-term efficacy and safety of transobturator four-arm @entity4 mesh in the treatment of high-stage anterior @entity3 and concomitant stress @entity1 (SUI). MATERIALS AND METHODS: Between September 2010 and August 2013, a prospective single-center trial was performed to evaluate @entity0 with stage>= 3 anterior @entity3 with or without SUI who presented to Labbafinejad Hospital, Teheran, Iran, and underwent anterior vaginal wall repair with @entity4 mesh. Pre- and postoperative evaluation included history; physical examination using the Pelvic Organ Prolapse Quantification system and cough stress test, both before and after reduction of prolapsed structures; Pelvic Floor Distress Inventory (PFDI) and Pelvic Floor Impact Questionnaire (PFIQ); urinalysis and culture; and a postvoid residual assessment. Complications were reported at a mean of 2 years of follow-up. RESULTS: A total of 71 @entity0 underwent cystocele repair with the transobturator four-arm @entity4 mesh. Seven of the @entity0 were lost to follow-up. There were no perioperative complications. The anatomical success rate was 87.5%. The subjective success rate was 92.1%. The PFDI and PFIQ were significantly improved after surgery (p<0.001). Among those with the simultaneous complaint of SUI, 82% were cured without any additional procedure. Three @entity0 (4.6%) experienced vaginal mesh extrusion. Two @entity0 (3.1%) reported worsening of @entity2 after surgery. CONCLUSIONS: The four arms @entity4 mesh is an effective device for simultaneous correction of anterior @entity3 and SUI with a low complication rate at a medium-term follow-up. The majority of the subgroup with concomitant SUI were cured without a second simultaneous procedure.

title: Simultaneous treatment of anterior @entity3 and stress @entity1 by using transobturator four arms XXXX mesh.

answer: @entity4


abstract: BACKGROUND: During the @entity3 outbreak in Ireland and the UK in 2001, there was significant uncertainty amongstveterinary practitioners and government veterinary inspectors surrounding the clinical diagnosis of @entity3 insheep. This situation was complicated by reports of @entity4 that closely resembled @entity3 ongross appearance which at that time were referred to as @entity2 and gum obscure disease. METHODS: A field and abattoir study was carried out to determine the frequency, appearance and significance of oraland digital lesions in @entity1 in Ireland. A total of 3, 263 @entity1 were examined in 22 flocks, including 1, 969 @entity1 and 1, 294 adults. A further 2,403 animals were examined by abattoir inspections. Animals bearing lesions of interest were identified, samples of the lesions were taken and subsequently examined by bacteriology, electron microscopy, serology, immunohistochemistry and histopathology. RESULTS: Forty four oral and 20 digital lesions were identified and characterised. @entity0 were recorded mostfrequently in @entity1 , where the most common cause was @entity6 infection. The majority of the oral lesions recorded in the adults was idiopathic and consistent with a diagnosis of @entity4 . A variety of digital lesions was observed, consistent with scald, foot-rot and @entity5 ( @entity5 ). All of the animals with lesions were seronegative to @entity3 virus (FMDV). CONCLUSIONS: There was no difficulty in differentiating these lesions from those caused by FMDV on the basis of flockhistory and careful clinical examination.

title: Profiling oral and digital lesions in XXXX in Ireland.

answer: @entity1


abstract: OBJECTIVE: To investigate to what extent vocational rehabilitation and working on a trial basis have an impact on employment after rehabilitation. DESIGN: Follow-up survey, conducted in 1991, among all @entity0 , aged 14 to 64, who were treated between 1984 and 1987. SETTING: An out-clinic department of a rehabilitation center in the west of The Netherlands. SUBJECTS: 395 @entity0 (59% of the original sample) participated in the study. They suffer from @entity2 due to back @entity4 (41%), @entity6 (20%), @entity1 (12%), @entity3 to the upper and/or lower extremities (8%), @entity5 (7%), or other disorders (12%). No differences were found between those who did and those who did not respond with regard to age, gender, marital status, disorder, work experience, and participation in vocational rehabilitation. MAIN OUTCOME MEASURE: Odds ratio of having a paid job after rehabilitation. RESULTS: Participation in vocational rehabilitation and working on a trial basis depends on age, gender, work experience, and disorder. When statistically controlled for these variables vocational rehabilitation (odds ratio 1.96; 95% confidence interval 1.12 to 3.42) and working on a trial basis (odds ratio 3.26; 95% confidence interval 1.74 to 6.11) proved to have a significant impact on employment after rehabilitation. CONCLUSIONS: The findings suggest that rehabilitation programs that aim specifically at promoting employment for @entity0 with disabilities are effective, in particular when they take place in both a laboratory and a natural setting. The validity of this suggestion must be further tested by means of an experimental design.

title: Employment after rehabilitation for XXXX : the impact of vocational rehabilitation and working on a trial basis.

answer: @entity2


abstract: OBJECTIVE: To evaluate trunk muscle strength and performance in long-term survivors of childhood @entity1 relative to age and sex-matched controls, and to relate the muscle strength observations to the therapeutic agents used and possible hormonal disturbances. DESIGN: Age and sex-matched cohort study. SETTING: Referral center in the northern part of Finland. @entity0 : Forty-six long-term survivors of childhood @entity1 . Mean age at examination 19.1 years and median off-therapy time 9.4 years. INTERVENTION: Isokinetic dynamometer testing. MAIN OUTCOME MEASURES: Measurements of trunk muscle peak torque (PT) and @entity4 ( @entity4 ) were performed at angle speeds of 50 degrees/sec and 200 degrees/sec. The results were normalized relative to body fat-free weight (FFW). RESULTS: PT in the trunk muscles was lower in the @entity0 at both angle speeds (mean normalized PT = 5.7Nm/kgFFW vs 7.6Nm/kgFFW for controls at 50 degrees/sec), as also was @entity4 except for extension @entity4 at the higher angle speed (mean normalized @entity4 = 59.9J/kgFFW vs 84.6J/kgFFW for controls at 200 degrees/sec). The normalized PT at 50 degrees/sec and @entity4 at 200 degrees/sec were lower in the males with @entity2 ; also, low age at diagnosis correlated positively with muscle strength and performance. There were no differences in normalized PTs or TWDs between cranial radiation and non-radiation cases, or between @entity5 -deficient and @entity6 cases, and the @entity0 without cranial radiation or with normal growth hormone secretion still had lower normalized PTs and TWDs than the controls. CONCLUSIONS: Survivors of childhood @entity1 have decreased maximal trunk muscle strength and performance. The etiology of this effect remains unclear, but young age at diagnosis, as well as serum @entity3 levels in male survivors, evidently influence muscle strength and performance.

title: Decreased isokinetic trunk muscle strength and performance in long-term survivors of childhood XXXX : correlation with hormonal defects.

answer: @entity1


abstract: UNASSIGNED: @entity5 ( @entity5 ) is life-threatening and can result in severe sequelae. In France, no data have been published on the costs of severe @entity5 cases. Two realistic scenarios were developed with national experts (clinicians and social workers): a 6-year-old @entity0 with @entity6 with amputation of both legs below the knee (case A) and a 3-year-old with @entity2 and severe neurological sequelae (case B). Additional scenarios included other typical sequelae of @entity5 such as @entity3 ( @entity3 ), profound @entity4 and @entity1 . Data on healthcare, disability, educational and other resource use were obtained from experts and families of @entity0 with similar sequelae. Unit costs (2013) were mainly obtained from the literature and the National Health Insurance (NHI). Time horizon was based on life expectancies of @entity0 (77 and 55 years, respectively). A 4% discount rate decreasing to 2% after 30 years was applied. Costs are presented from the perspective of the NHI, publicly funded organizations and @entity0 ' families or their private health insurances. @entity6 with amputations is associated with a lifelong discounted cost of    768,875. Adding @entity3 doubles the amount (   1,480,545). @entity2 with severe neuro-cognitive sequelae results in a lifelong discounted cost of    1,924,475. Adding profound @entity4 and @entity1 slightly increases the total cost (   2,267,251). The first year is the most expensive in both scenarios (   166,890 and    160,647 respectively). The main cost drivers for each scenario are prostheses and @entity0 /adult stays in healthcare facilities, respectively. Overall, @entity0 ' families or his private insurance had to pay around 13% of total cost (101,833    and 258,817   , respectively). This study fills a gap in the body of knowledge on @entity5 sequelae care and lifetime costs in France. The potentially high economic burden of @entity5 , in addition to its physical, psychological and social burden, reinforces the need for prevention.

title: Lifetime cost of @entity5 in France: Scenarios of severe @entity2 and septicemia with XXXX .

answer: @entity6


abstract: UNASSIGNED: @entity5 ( @entity5 ) is life-threatening and can result in severe sequelae. In France, no data have been published on the costs of severe @entity5 cases. Two realistic scenarios were developed with national experts (clinicians and social workers): a 6-year-old @entity0 with @entity6 with amputation of both legs below the knee (case A) and a 3-year-old with @entity2 and severe neurological sequelae (case B). Additional scenarios included other typical sequelae of @entity5 such as @entity3 ( @entity3 ), profound @entity4 and @entity1 . Data on healthcare, disability, educational and other resource use were obtained from experts and families of @entity0 with similar sequelae. Unit costs (2013) were mainly obtained from the literature and the National Health Insurance (NHI). Time horizon was based on life expectancies of @entity0 (77 and 55 years, respectively). A 4% discount rate decreasing to 2% after 30 years was applied. Costs are presented from the perspective of the NHI, publicly funded organizations and @entity0 ' families or their private health insurances. @entity6 with amputations is associated with a lifelong discounted cost of    768,875. Adding @entity3 doubles the amount (   1,480,545). @entity2 with severe neuro-cognitive sequelae results in a lifelong discounted cost of    1,924,475. Adding profound @entity4 and @entity1 slightly increases the total cost (   2,267,251). The first year is the most expensive in both scenarios (   166,890 and    160,647 respectively). The main cost drivers for each scenario are prostheses and @entity0 /adult stays in healthcare facilities, respectively. Overall, @entity0 ' families or his private insurance had to pay around 13% of total cost (101,833    and 258,817   , respectively). This study fills a gap in the body of knowledge on @entity5 sequelae care and lifetime costs in France. The potentially high economic burden of @entity5 , in addition to its physical, psychological and social burden, reinforces the need for prevention.

title: Lifetime cost of XXXX in France: Scenarios of severe @entity2 and septicemia with @entity6 .

answer: @entity5


abstract: UNASSIGNED: @entity5 ( @entity5 ) is life-threatening and can result in severe sequelae. In France, no data have been published on the costs of severe @entity5 cases. Two realistic scenarios were developed with national experts (clinicians and social workers): a 6-year-old @entity0 with @entity6 with amputation of both legs below the knee (case A) and a 3-year-old with @entity2 and severe neurological sequelae (case B). Additional scenarios included other typical sequelae of @entity5 such as @entity3 ( @entity3 ), profound @entity4 and @entity1 . Data on healthcare, disability, educational and other resource use were obtained from experts and families of @entity0 with similar sequelae. Unit costs (2013) were mainly obtained from the literature and the National Health Insurance (NHI). Time horizon was based on life expectancies of @entity0 (77 and 55 years, respectively). A 4% discount rate decreasing to 2% after 30 years was applied. Costs are presented from the perspective of the NHI, publicly funded organizations and @entity0 ' families or their private health insurances. @entity6 with amputations is associated with a lifelong discounted cost of    768,875. Adding @entity3 doubles the amount (   1,480,545). @entity2 with severe neuro-cognitive sequelae results in a lifelong discounted cost of    1,924,475. Adding profound @entity4 and @entity1 slightly increases the total cost (   2,267,251). The first year is the most expensive in both scenarios (   166,890 and    160,647 respectively). The main cost drivers for each scenario are prostheses and @entity0 /adult stays in healthcare facilities, respectively. Overall, @entity0 ' families or his private insurance had to pay around 13% of total cost (101,833    and 258,817   , respectively). This study fills a gap in the body of knowledge on @entity5 sequelae care and lifetime costs in France. The potentially high economic burden of @entity5 , in addition to its physical, psychological and social burden, reinforces the need for prevention.

title: Lifetime cost of @entity5 in France: Scenarios of severe XXXX and septicemia with @entity6 .

answer: @entity2


abstract: Soluble @entity9 kinase (NDP kinase) from @entity8 was purified to electrophoretic homogeneity and a partial sequence was determined. The enzyme was kinetically and physically characterized. @entity7 - @entity4 gel electrophoresis of the purified enzyme revealed a single polypeptide of 17 kDa upon staining, by immunodetection with heterologous and homologous antibodies, and by autoradiography of the phosphorylated enzyme. Furthermore, isoelectric focusing of the purified native enzyme showed a single acidic band (pI 4.5). These results together with a native molecular mass of 98 kDa suggest a hexameric native enzyme composed of identical subunits. Like NDP kinases from other sources, the catalysis involves a phosphoenzyme intermediate that is rapidly formed upon incubation of the enzyme with @entity1 . The transfer of @entity3 from phosphoprotein intermediate to @entity9 is equally fast. Kinetic experiments indicated that @entity6 and @entity1 had the lowest Km compared to @entity2 , dTTP, and @entity0 . @entity5 acted as a preferred acceptor as assessed by kinetic measurements as well as by competition experiments. Experimental data are presented indicating the existence of a membrane-associated NDP kinase. Preliminary characterization of this enzyme suggests that cytosolic and membrane-associated NDP kinases are similar proteins.

title: @entity8 XXXX kinase: purification and characterization.

answer: @entity9