abstract: OBJECTIVE: @entity3 ( @entity3 ) is assumed to enhance poststroke motor recovery, yet its benefits are debatable. Brain-computer interfaces (BCIs) can provide instantaneous and quantitative measure of cerebral functions modulated by @entity3 . The efficacy of BCI-monitored @entity3 practice as add-on intervention to usual rehabilitation care was evaluated in a randomized controlled pilot study in subacute @entity1 @entity0 . METHODS: Twenty-eight hospitalized subacute @entity1 @entity0 with severe motor deficits were randomized into 2 intervention groups: 1-month BCI-supported @entity3 training (BCI group, n   =   14) and 1-month @entity3 training without BCI support (control group; n   =   14). Functional and neurophysiological assessments were performed before and after the interventions, including evaluation of the upper limbs by Fugl-Meyer Assessment (FMA; primary outcome measure) and analysis of oscillatory activity and connectivity at rest, based on high-density electroencephalographic (EEG) recordings. RESULTS: Better functional outcome was observed in the BCI group, including a significantly higher probability of achieving a clinically relevant increase in the FMA score (p   <   0.03). Post-BCI training changes in EEG sensorimotor power spectra (ie, stronger desynchronization in the alpha and beta bands) occurred with greater involvement of the ipsilesional hemisphere in response to @entity3 of the paralyzed trained hand. Also, FMA improvements (effectiveness of FMA) correlated with the changes (ie, post-training increase) at rest in ipsilesional intrahemispheric connectivity in the same bands (p   <   0.05). INTERPRETATION: The introduction of BCI technology in assisting @entity3 practice demonstrates the rehabilitative potential of @entity3 , contributing to significantly better motor functional outcomes in subacute @entity1 @entity0 with severe @entity2 . Ann Neurol 2015.

title: Brain-computer interface boosts motor imagery practice during XXXX recovery.

answer: @entity1


abstract: UNASSIGNED: @entity0 is a chronic @entity3 accompanied by several comorbidities, including neuropsychiatric conditions. Since the @entity5 appears to be the primary factor involved in @entity0 conditions, we examined the effect of insulin treatment in @entity0 @entity1 on behavioral responses related to @entity2 and aversive memory extinction. For this, normoglycemic (NGL) or @entity4 - @entity0 (DBT) @entity1 were submitted to the elevated T maze (ETM) and the contextual conditioned fear (CCF) tests. Therefore, animals were subjected to the prolonged treatment with insulin (6  IU/day, s.c.) to investigate the effect of the treatment on distinct behaviors. When @entity2 -like responses such as the inhibitory avoidance (IA) on the ETM and the time of freezing in the first session of the CCF test were evaluated, our data showed a more pronounced anxiogenic-like behavior in DBT animals when compared to NGL ones. In addition, an increased freezing time was observed in DBT animals exposed to the CCF test (sessions 2 and 3) when compared to the NGL group, suggestive of an impairment in the extinction of aversive memory. Insulin treatment induced an anxiolytic-like effect when IA and freezing time (session 1) was evaluated, but did not alter the impaired extinction of aversive memory (sessions 2 and 3). To better understand the involvement of a rigorous control of glycaemia, we also investigated the effect of a lower dose of insulin (3  IU/day, s.c.), unable to reestablish the @entity5 to the normal levels, on the same behavioral parameters. Our data show that independent of the dose of insulin, the same effects were observed when animals were evaluated in the ETM and CCF tests. However, only the highest dose of insulin was able to reduce the @entity5 to the normal levels. To conclude, our data suggest that a severe glycemic control by insulin treatment seems to be important, but not essential in improving @entity0 -induced @entity2 .

title: Reestablishment of the XXXX to the normal levels seems not to be essential to the anxiolytic-like effect induced by insulin.

answer: @entity5


abstract: BACKGROUND: Survival rates are commonly used to measure success in treating @entity1 , but can be misleading. Modern diagnostic practices can lead to the appearance of improving @entity1 survival, as @entity1 are diagnosed earlier (lead-time bias) or as an increasing proportion are slow-growing (length bias), whereas the actual burden of @entity1 deaths is unchanged. Increasingly, more @entity2 are being diagnosed. The objective of the current study was to determine whether @entity2 survival rates have been affected by this phenomenon. METHODS: The authors analyzed survival data from @entity0 with @entity2 who were treated at Memorial Sloan Kettering @entity1 Center (MSKCC) from 1950 to 2005, and United States population-based incidence, prevalence, and survival data from 1973 to 2009 in the Surveillance, Epidemiology, and End Results data set. RESULTS: US @entity2 incidence has increased 3-fold from 1975 to 2009. Over time, the proportion of @entity2 that are subcentimeter in size has increased from 23% (1983) to 36% (2009). At MSKCC, this percentage rose from 20% (1950) to 35% (2005). The incidence rates of large @entity1 (>6 cm) and distant metastasis have not changed. In the United States, 10-year relative survival improved from 95.4% to 98.6% (1983-1999). At MSKCC, 10-year disease-specific survival improved from 91.1% to 96.1% (1950-2005). However, when stratified by @entity1 size and stage, no changes in survival outcomes were observed. US @entity2 mortality rates have remained stable (1975-2009). CONCLUSIONS: Modern medical practices increasingly uncover small, asymptomatic @entity2 . Survival rates appear improved, but this finding is spurious, attributable instead to shifts in the characteristics of disease being diagnosed. Relying on survival rates to measure success in treating @entity2 may reinforce inappropriately aggressive management. Treatment decisions in @entity2 should be made based on mortality, not survival data. @entity1 2015.    2014 American @entity1 Society.

title: Increasing diagnosis of XXXX leads to spurious improvements in survival rates.

answer: @entity2


abstract: UNASSIGNED: @entity5 ( @entity5 , @entity7 #117550) is an @entity8 . Deletions or intragenic mutations of the @entity6 , which is located at chromosome 5q35, are responsible for more than 75% of @entity5 . Conventionally, @entity2 was reported briefly as one of the infrequent symptoms of @entity5 . However, Matsuo et al. published a report describing five @entity0 with @entity5 who presented with transient @entity1 ( @entity1 ) in the neonatal period. We report on an additional @entity0 of @entity5 , who presented transient @entity1 in the neonatal period. All of this @entity0 and previous @entity0 have microdeletions at the 5q35 chromosome. Therefore, we examined the following three in considering the possibility that other factor than @entity6 caused @entity1 . 1) This @entity0 had no mutation of four currently known @entity1 related genes, @entity3 , @entity4 , @entity9 , and GCK. 2) He had no further deletion than commonly observed region encompassing @entity6 by comparative genomic hybridization to DNA microarrays. 3) He had no mutation in the 5q35 region in the non-deleted chromosome using exsome sequence analysis. In conclusion, our @entity0 supported that @entity1 could be one of the characteristic symptoms of @entity5 in the neonatal period, and could be useful for early diagnosis.    2015 Wiley Periodicals, Inc.

title: A case with neonatal XXXX : It is a characteristic complication of sotos syndrome.

answer: @entity1


abstract: OBJECTIVE: The aim was to evaluate the feasibility and safety of early chest tube removal after complete video-assisted @entity6 (CVATL). METHODS: Retrospective analysis was performed on effects of chest tube removal on @entity0 with @entity1 after pulmonary lobectomy between November 2013 and October 2014. 154 eligible @entity0 included 97 cases for CVATL and 57 cases for open @entity6 . @entity0 with CVATL were divided randomly into experimental group (EG) and control group (CG), in which 51 @entity0 in EG had chest tube removal on the 2 nd day after operation; 46 @entity0 in CG had the tube removal when the drainage volume <100 ml/day. @entity0 in open @entity6 group (OG) had the tubes removal as CG. The drainage volumes of the 1 st and 2 nd 24 h after operation, duration of chest tubes, cases of @entity2 alleviation, and recurrent @entity5 requiring reintervention were measured. RESULTS: The average drainage volume of the 1 st 24 h after operation of CVATL group from EG and CG was significantly reduced than that in OG (260.41 ml vs. 353.16 ml, P < 0.001). The average drainage volume of the 2 nd 24 h after operation of CG was significantly reduced than that in OG (163.91 ml vs. 222.98 ml, P < 0.001). The average duration of chest tube of CG for 2.98 days showed significant different compared with OG for 3.81 days (P < 0.001). Chest tube removal in CVATL group increased more @entity4 alleviation than OG (80.4% vs. 56.1%, P = 0.001). The frequencies of recurrent @entity5 requiring reintervention were 5.88% (3/51), 4.35% (2/46) and 5.26% (3/57), respectively, which had no significant differences between three groups (P = 1.000). CONCLUSIONS: Complete video-assisted @entity6 brings less drainage volume after operation. Early removal of chest tube in CVATL shows feasible and safe and demonstrates that it may reduce @entity3 and help fast recovery.

title: Feasibility and safety of early chest tube removal after complete video-assisted XXXX .

answer: @entity6


abstract: UNASSIGNED: In a cohort study of 182 consecutive @entity0 with active endogenous @entity3 , the only predictor of @entity2 occurrence after adjustment for age, gender @entity1 ( @entity1 ) and @entity1 ( @entity1 ) was 24-h urinary free @entity4 (24hUFC) levels with a threshold of 1472  nmol/24  h (odds ratio, 3.00 (95  % confidence interval (CI), 1.52-5.92); p   =   0.002). INTRODUCTION: The aim was to estimate the risk factors for @entity2 in subjects with endogenous @entity3 ( @entity3 ) and to evaluate the value of the @entity1 in these @entity0 . METHODS: All enrolled @entity0 with @entity3 (n   =   182) were interviewed in relation to low-traumatic @entity2 and underwent lateral X-ray imaging from T4 to L5. @entity1 measurements were performed using a DXA Prodigy device (GEHC Lunar, Madison, Wisconsin, USA). The @entity1 was derived retrospectively from existing @entity1 scans, blinded to clinical outcome, using @entity1 iNsight software @entity5 (Medimaps, Merignac, France). Urinary free @entity4 (24hUFC) was measured by immunochemiluminescence assay (reference range, 60-413  nmol/24  h). RESULTS: Among enrolled @entity0 with @entity3 (149 females; 33 males; mean age, 37.8  years (95  % confidence interval, 34.2-39.1); 24hUFC, 2370  nmol/24  h (2087-2632), @entity2 were confirmed in 81 (44.5  %) @entity0 , with 70 suffering from @entity2 , which were multiple in 53 cases; 24 @entity0 reported @entity2 . The mean spine @entity1 was 1.207 (1.187-1.228), and @entity1 Z-score was -1.86 (-2.07 to -1.65); area under the curve (AUC) was used to predict @entity2 (mean spine @entity1 )   =   0.548 (95  % CI, 0.454-0.641)). In the final regression model, the only predictor of @entity2 occurrence was 24hUFC levels (p   =   0.001), with an increase of 1.041 (95  % CI, 1.019-1.063), calculated for every 100  nmol/24-h @entity4 elevation (AUC (24hUFC)   =   0.705 (95  % CI, 0.629-0.782)). CONCLUSIONS: Young @entity0 with @entity3 have a low @entity1 . However, the only predictor of low traumatic @entity2 is the severity of the disease itself, indicated by high 24hUFC levels.

title: The risk factors for XXXX and trabecular bone-score value in @entity0 with endogenous @entity3 .

answer: @entity2


abstract: UNASSIGNED: In a cohort study of 182 consecutive @entity0 with active endogenous @entity3 , the only predictor of @entity2 occurrence after adjustment for age, gender @entity1 ( @entity1 ) and @entity1 ( @entity1 ) was 24-h urinary free @entity4 (24hUFC) levels with a threshold of 1472  nmol/24  h (odds ratio, 3.00 (95  % confidence interval (CI), 1.52-5.92); p   =   0.002). INTRODUCTION: The aim was to estimate the risk factors for @entity2 in subjects with endogenous @entity3 ( @entity3 ) and to evaluate the value of the @entity1 in these @entity0 . METHODS: All enrolled @entity0 with @entity3 (n   =   182) were interviewed in relation to low-traumatic @entity2 and underwent lateral X-ray imaging from T4 to L5. @entity1 measurements were performed using a DXA Prodigy device (GEHC Lunar, Madison, Wisconsin, USA). The @entity1 was derived retrospectively from existing @entity1 scans, blinded to clinical outcome, using @entity1 iNsight software @entity5 (Medimaps, Merignac, France). Urinary free @entity4 (24hUFC) was measured by immunochemiluminescence assay (reference range, 60-413  nmol/24  h). RESULTS: Among enrolled @entity0 with @entity3 (149 females; 33 males; mean age, 37.8  years (95  % confidence interval, 34.2-39.1); 24hUFC, 2370  nmol/24  h (2087-2632), @entity2 were confirmed in 81 (44.5  %) @entity0 , with 70 suffering from @entity2 , which were multiple in 53 cases; 24 @entity0 reported @entity2 . The mean spine @entity1 was 1.207 (1.187-1.228), and @entity1 Z-score was -1.86 (-2.07 to -1.65); area under the curve (AUC) was used to predict @entity2 (mean spine @entity1 )   =   0.548 (95  % CI, 0.454-0.641)). In the final regression model, the only predictor of @entity2 occurrence was 24hUFC levels (p   =   0.001), with an increase of 1.041 (95  % CI, 1.019-1.063), calculated for every 100  nmol/24-h @entity4 elevation (AUC (24hUFC)   =   0.705 (95  % CI, 0.629-0.782)). CONCLUSIONS: Young @entity0 with @entity3 have a low @entity1 . However, the only predictor of low traumatic @entity2 is the severity of the disease itself, indicated by high 24hUFC levels.

title: The risk factors for @entity2 and trabecular bone-score value in @entity0 with endogenous XXXX .

answer: @entity3


abstract: UNASSIGNED: In a cohort study of 182 consecutive @entity0 with active endogenous @entity3 , the only predictor of @entity2 occurrence after adjustment for age, gender @entity1 ( @entity1 ) and @entity1 ( @entity1 ) was 24-h urinary free @entity4 (24hUFC) levels with a threshold of 1472  nmol/24  h (odds ratio, 3.00 (95  % confidence interval (CI), 1.52-5.92); p   =   0.002). INTRODUCTION: The aim was to estimate the risk factors for @entity2 in subjects with endogenous @entity3 ( @entity3 ) and to evaluate the value of the @entity1 in these @entity0 . METHODS: All enrolled @entity0 with @entity3 (n   =   182) were interviewed in relation to low-traumatic @entity2 and underwent lateral X-ray imaging from T4 to L5. @entity1 measurements were performed using a DXA Prodigy device (GEHC Lunar, Madison, Wisconsin, USA). The @entity1 was derived retrospectively from existing @entity1 scans, blinded to clinical outcome, using @entity1 iNsight software @entity5 (Medimaps, Merignac, France). Urinary free @entity4 (24hUFC) was measured by immunochemiluminescence assay (reference range, 60-413  nmol/24  h). RESULTS: Among enrolled @entity0 with @entity3 (149 females; 33 males; mean age, 37.8  years (95  % confidence interval, 34.2-39.1); 24hUFC, 2370  nmol/24  h (2087-2632), @entity2 were confirmed in 81 (44.5  %) @entity0 , with 70 suffering from @entity2 , which were multiple in 53 cases; 24 @entity0 reported @entity2 . The mean spine @entity1 was 1.207 (1.187-1.228), and @entity1 Z-score was -1.86 (-2.07 to -1.65); area under the curve (AUC) was used to predict @entity2 (mean spine @entity1 )   =   0.548 (95  % CI, 0.454-0.641)). In the final regression model, the only predictor of @entity2 occurrence was 24hUFC levels (p   =   0.001), with an increase of 1.041 (95  % CI, 1.019-1.063), calculated for every 100  nmol/24-h @entity4 elevation (AUC (24hUFC)   =   0.705 (95  % CI, 0.629-0.782)). CONCLUSIONS: Young @entity0 with @entity3 have a low @entity1 . However, the only predictor of low traumatic @entity2 is the severity of the disease itself, indicated by high 24hUFC levels.

title: The risk factors for @entity2 and trabecular bone-score value in XXXX with endogenous @entity3 .

answer: @entity0


abstract: UNASSIGNED: @entity5 is a poor-prognosis malignancy that ranks eighth among all @entity1 types, and its prevalence shows differences among geographical regions. Although the most important risk factors for @entity5 are @entity4 and smoking, @entity8 , particularly @entity3 , are also considered among etiological agents. Our study aims to detect the presence of @entity5 in our @entity0 population and to investigate its correlation with clinico-pathological parameters. We investigated the presence of HPV-DNA by real-time polymerase chain reaction in a total of 52 @entity0 with @entity5 . Subtype analysis was performed in positive cases and was correlated with selected clinico-pathological parameters. Five (9.6%) of 52 @entity1 samples, 3 @entity7 (3/33 cases) and 2 @entity6 (2/19 cases), were HPV-DNA-positive. Subtype analysis could be performed in four HPV-DNA-positive cases, of which three were HPV type-39 and 1 was type-16. The Marmara region, where the present study was carried out, is a region with low-moderate risk for @entity5 , and the prevalence of HPV-DNA in these @entity1 is similar to the prevalence of HPV-DNA reported in the literature for regions with similar risk. In conclusion, we detected HPV DNA in a subset of esophageal and @entity1 . @entity3 may have a role in esophageal @entity2 and high-risk HPV subtypes can particularly be considered among risk factors since the prevalence of high risk @entity3 has also been found to be increased in regions with a high risk for @entity5 compared to low-moderate risk regions.

title: Detection of human papillomavirus in esophageal and XXXX : A retrospective study by real-time polymerase chain reaction in an instutional experience from Turkey and review of literature.

answer: @entity1


abstract: OBJECTIVE: @entity4 ( @entity4 ) is the only management for @entity2 ( @entity2 ). Available methods to assess @entity4 compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause @entity1 . We aimed to develop a method to determine gluten intake and monitor @entity4 compliance in @entity0 with @entity2 and to evaluate its correlation with @entity1 . DESIGN: Urine samples of 76 healthy subjects and 58 @entity0 with @entity2 subjected to different gluten dietary conditions were collected. A lateral flow test (LFT) with the highly sensitive and specific G12 monoclonal antibody for the most dominant gluten immunogenic peptides (GIP) and a LFT reader were used to quantify GIP in solid-phase extracted urines. RESULTS: GIP were detectable in concentrated urines from healthy individuals previously subjected to @entity4 as early as 4-6   h after single gluten intake, and remained detectable for 1-2   days. The urine assay revealed infringement of the @entity4 in about 50% of the @entity0 . Analysis of duodenal biopsies revealed that most of @entity0 with @entity2 (89%) with no villous @entity3 had no detectable GIP in urine, while all @entity0 with quantifiable GIP in urine showed incomplete intestinal mucosa recovery. CONCLUSION: GIP are detected in urine after gluten consumption, enabling a new and non-invasive method to monitor @entity4 compliance and transgressions. The method was sensitive, specific and simple enough to be convenient for clinical monitoring of @entity0 with @entity2 as well as for basic and clinical research applications including drug development. TRIAL REGISTRATION NUMBER: NCT02344758.

title: Detection of gluten immunogenic peptides in the urine of @entity0 with XXXX reveals transgressions in the gluten-free diet and incomplete mucosal healing.

answer: @entity2


abstract: OBJECTIVE: @entity4 ( @entity4 ) is the only management for @entity2 ( @entity2 ). Available methods to assess @entity4 compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause @entity1 . We aimed to develop a method to determine gluten intake and monitor @entity4 compliance in @entity0 with @entity2 and to evaluate its correlation with @entity1 . DESIGN: Urine samples of 76 healthy subjects and 58 @entity0 with @entity2 subjected to different gluten dietary conditions were collected. A lateral flow test (LFT) with the highly sensitive and specific G12 monoclonal antibody for the most dominant gluten immunogenic peptides (GIP) and a LFT reader were used to quantify GIP in solid-phase extracted urines. RESULTS: GIP were detectable in concentrated urines from healthy individuals previously subjected to @entity4 as early as 4-6   h after single gluten intake, and remained detectable for 1-2   days. The urine assay revealed infringement of the @entity4 in about 50% of the @entity0 . Analysis of duodenal biopsies revealed that most of @entity0 with @entity2 (89%) with no villous @entity3 had no detectable GIP in urine, while all @entity0 with quantifiable GIP in urine showed incomplete intestinal mucosa recovery. CONCLUSION: GIP are detected in urine after gluten consumption, enabling a new and non-invasive method to monitor @entity4 compliance and transgressions. The method was sensitive, specific and simple enough to be convenient for clinical monitoring of @entity0 with @entity2 as well as for basic and clinical research applications including drug development. TRIAL REGISTRATION NUMBER: NCT02344758.

title: Detection of gluten immunogenic peptides in the urine of XXXX with @entity2 reveals transgressions in the gluten-free diet and incomplete mucosal healing.

answer: @entity0


abstract: INTRODUCTION. The term adoption or adoptive filiation is understood as referring to the legal act by which family ties are created between two @entity0 such that a relationship of fatherhood or motherhood is established between them. AIMS. The purpose of this study is to outline the problems derived from prenatal exposure to @entity2 and other risk factors, from hypostimulation during the 'critical period' in institutionalised @entity0 (especially those adopted from eastern European countries) and their relation with @entity1 ( @entity1 ). This work also seeks to take a deeper look into the diagnosis, prevention and treatment of these problems. DEVELOPMENT. These @entity0 have problems in terms of psychosocial relationships, behavioural problems, delayed language or reading development and, above all, @entity1 . In practice it is extremely difficult to separate the two factors during the assessment of @entity0 adopted from eastern European countries in neuropaediatric consultations. Exactly how all these factors are interrelated is not well understood. CONCLUSIONS. There is a close relationship between prenatal exposure to @entity2 and the consequences of adoption. There is a need for placebo-controlled randomised studies, with larger population samples, that test the benefits and profile of side effects, both with psychostimulants and with @entity3 in this group of @entity0 .

title: [Attention XXXX and adoption].

answer: @entity1


abstract: OBJECTIVE: The objective was to explore the determinants of menstrual hygienic practices and its effect on @entity1 ( @entity1 ) among ever married @entity0 in India. METHODS: District Level Household and Facility Survey-3 (DLHS) India data have been used in the study. The respondents constituted ever married @entity0 (N   =   577,758) in the age group of 15-49. Bivariate and multivariate techniques were employed using IBM SPSS statistics 20. Individual effects of socio economic, demographic and gynecological factors on menstrual hygienic practices, RTIs and abnormal vaginal discharged respectively were calculated using binary logistic regression. RESULTS: A meager 15% of @entity0 used sanitary pad/locally prepared napkins during menstruation in India. Both @entity1 and Vaginal discharge were positively related with non-use of hygienic methods. The @entity0 who used unhygienic method during menstruation were more likely to have any symptom of @entity1 (OR   =   1.046, p   <   0.001, CI   =   1.021-1.071) and vaginal discharge (OR   =   1.303, p   <   0.001, CI   =   1.266-1.341). CONCLUSION: The reason for the symptoms of @entity1 may be diverse and not only limited to the unhygienic menstrual practices although this may be one of the reasons causing reproductive morbidity. Awareness, affordability and privacy are some of the major concerns that need immediate attention to promote the use of sanitary pad during the time of menstruation. Establishing relation between menstrual practices and @entity1 is in its initial stage of investigation and hence needs further research.

title: Menstrual hygiene practices and its association with reproductive tract infections and abnormal vaginal discharge among XXXX in India.

answer: @entity0


abstract: INTRODUCTION. The difficulties that @entity0 with @entity1 ( @entity1 ) have when it comes to emotional regulation have aroused a great deal of interest in recent years and there is a line of research working on the identification of the neurophysiological correlates. AIMS. To analyse measures of emotional functioning and their correlation with the @entity2 component in a sample of @entity0 with @entity1 with and without treatment. @entity0 AND METHODS. The sample was made up of 71 @entity0 with @entity1 , almost half of whom were taking some form of medication. The auditory potential @entity2 was analysed. The parents filled in a scale to assess executive behaviour at home, the Behavior Rating Inventory of Executive Function (BRIEF), which the emotional self-regulation index and the emotional expression scale were taken from. RESULTS. Significant correlations were found between the amplitude of the @entity2 and the emotional self-regulation index from the version of the BRIEF for preschoolers, and a relation was observed between @entity2 latency and the severity of the symptoms. CONCLUSIONS. The results highlight the usefulness of evoked potentials for the study of executive correlates and associated conditions in the day-to-day functioning of @entity0 with @entity1 .

title: [Emotional self-regulation in infantile XXXX and @entity2 evoked potentials].

answer: @entity1


abstract: INTRODUCTION. The difficulties that @entity0 with @entity1 ( @entity1 ) have when it comes to emotional regulation have aroused a great deal of interest in recent years and there is a line of research working on the identification of the neurophysiological correlates. AIMS. To analyse measures of emotional functioning and their correlation with the @entity2 component in a sample of @entity0 with @entity1 with and without treatment. @entity0 AND METHODS. The sample was made up of 71 @entity0 with @entity1 , almost half of whom were taking some form of medication. The auditory potential @entity2 was analysed. The parents filled in a scale to assess executive behaviour at home, the Behavior Rating Inventory of Executive Function (BRIEF), which the emotional self-regulation index and the emotional expression scale were taken from. RESULTS. Significant correlations were found between the amplitude of the @entity2 and the emotional self-regulation index from the version of the BRIEF for preschoolers, and a relation was observed between @entity2 latency and the severity of the symptoms. CONCLUSIONS. The results highlight the usefulness of evoked potentials for the study of executive correlates and associated conditions in the day-to-day functioning of @entity0 with @entity1 .

title: [Emotional self-regulation in infantile @entity1 and XXXX evoked potentials].

answer: @entity2


abstract: UNASSIGNED: Background: Although several authors have studied the association between @entity7 ( @entity7 ) and @entity2 , the matter is still controversial; few have suggested an association between cryptogenetic @entity2 and @entity7 , while others have denied this association. The aim of this study was to evaluate @entity7 prevalence in the whole @entity2 population, independently from age and @entity2 subtypes and to identify the characteristics associated with the presence of @entity7 . Methods: SISIFO study was a multicenter, prospective, single-wave, cross-sectional survey conducted on consecutive @entity0 with acute @entity5 admitted to selected clinical centres. Data regarding vascular risk factors were registered for each @entity0 ; all @entity0 underwent computed tomography scan and/or magnetic resonance imaging of the brain; an electrocardiogram and standard laboratory blood tests were performed. A Doppler ultrasound study of extra-cranial arteries was performed too. The cases were classified according to TOAST and OCSP criteria. Each @entity0 underwent transcranial Doppler or transcranial color-coded duplex sonography with bubble test as diagnostic tool for right-to-left-shunt. Where right-to-left shunt was detected, @entity7 presence was confirmed by echocardiography. Findings: 1,130 consecutive @entity0 were included. We found a @entity7 in 247 (21.9%; 95% CI, 19.5-24.3%) @entity0 ; @entity7 was present in 23.5% of @entity0 with cryptogenic @entity2 and in 21.3% of @entity0 with @entity2 of known causes; this difference was not statistically significant. At the univariate analysis, decreasing age, @entity3 , @entity1 , and @entity6 , and @entity2 characteristics such as NIHSS, OCSP and TOAST were predictors of @entity7 presence. At the multivariate analysis, we found a significant interaction between age and OCSP syndrome. Being LACI the reference category, the prevalence of @entity7 in PACI and POCI decreased significantly along with age, whereas there was no change in @entity8 . Conclusion: If any relationship exists between @entity2 and @entity7 , this is more likely in PACI and POCI at a younger age. Our results are consistent with recent findings that underline @entity7 alone must not be considered a significant independent predictor for @entity2 ; so the presence of @entity7 alone doesn't permit rushed causal correlations or 'therapeutic @entity4 '.    2015 S. Karger AG, Basel.

title: Prevalence of Patent Foramen Ovale in XXXX in Italy: Results of SISIFO Study.

answer: @entity2


abstract: INTRODUCTION: @entity1 are commonly encountered a problem and constitute more than 50% of cases in dermatology outpatient departments. Diagnosis of these infections requires the proper use of laboratory methods. OBJECTIVES: This study was conducted to know the etiology of @entity5 in @entity0 attending Tertiary Care Level Hospital in South India and to compare the efficacy of Sabouraud's dextrose agar (SDA) with @entity2 and dermatophyte test medium (DTM) in isolating and identifying dermatophytes. MATERIALS AND METHODS: A total of 110 samples which included 101 skin samples and 9 hair samples from clinically suspected @entity5 were collected. Direct microscopy by @entity3 and culture on SDA with @entity2 and DTM were done. RESULTS: Of 110 samples collected, 58.18% were @entity3 positive for fungal filaments and 56.36% were culture positive for dermatophytes. More number of cases were observed between age groups of 21-40 years. Males were more affected compared to females. @entity5 was the common clinical presentation observed (40%). @entity6 (58.06%) was the predominant isolate recovered in all clinical presentations but @entity6 violaceum was the most common isolate in @entity4 . All culture positives were grown on both SDA with @entity2 and DTM. Appearance of growth was earlier on DTM that is, within 10 days compared to SDA with @entity2 where growth started appearing only after 10 days. This is statistically significant P < 0.0001 (  (2) = 71.6). Species level identification on primary isolation was possible when grown on SDA with @entity2 and it was not possible with the growth on DTM on primary isolation. CONCLUSION: DTM is a good screening medium in laboratory diagnosis of @entity5 when compared to SDA with @entity2 . But DTM is inferior to SDA with @entity2 in identification of dermatophyte species.

title: Clinicomycological Study of XXXX .

answer: @entity5


abstract: BACKGROUND: @entity6 is a relatively common @entity4 , the etiological factors of which vary widely in different geographic location. Determining the specific etiology is of immense importance for appropriate management. AIMS AND OBJECTIVES: The present study was undertaken to delineate etiological factors leading to @entity6 in a Tertiary Care Hospital of West Bengal from Eastern Region of India. MATERIALS AND METHODS: A prospective study was conducted for a period of 2 years in which 248 @entity0 were included. After obtaining a relevant clinical history, physical examination was done followed by complete blood count including peripheral blood smears examination, relevant biochemical, and radiological investigations. Afterward, bone marrow aspiration and biopsy were performed and microscopically examined. RESULTS: Among 248 @entity0 studied, 156 (62.9%) were males and 92 (37.09%) were females. The mean age of the @entity0 was 33 years. @entity5 was the most common cause of @entity6 that was observed in 83 cases (33.47%) followed by @entity3 in 52 cases (20.97%), @entity1 in 34 @entity0 (13.71%), @entity7 also in 34 @entity0 (13.71%), and @entity2 and other connective tissue disorders in 18 cases (7.26%). The occurrence of @entity5 was statistically significant in pediatric ( <=15 years) age group. CONCLUSION: @entity5 was found to be the most common cause of @entity6 in this study, which is in contrast to studies conducted from other regions of India. Delineation of etiologies of @entity6 in various regions can help in defining diagnostic and therapeutic strategies, which is expected to contribute toward the better management of such @entity0 .

title: Etiology of XXXX : An Observation from a Referral Medical Institution of Eastern Region of India.

answer: @entity6


abstract: UNASSIGNED: Obesity which developes due to multifactorial reasons, was associated recently with @entity0 @entity4 ( @entity4 ). The aim of this study was to investigate the prevalence of @entity4 antibodies in @entity1 adults and also to investigate the DNA of @entity4 in their adipose tissue. In this cross-sectional and case-control based study, 49 @entity1 adults, with BMI >= 30  kg/m(2), and 49 non- @entity1 adults, with BMI  <=25  kg/m(2), applied for esthetic purposes and were included in this study as @entity0 and control groups, respectively. Adipose tissue samples, obtained by the lipoaspiration method, were studied by single-step PCR and nested-PCR methods. Simultaneously, the presence of @entity4 antibodies and serum leptin and adiponectin levels were assessed by serum neutralization assay (SNA) and ELISA, respectively. Serum samples which didn't cause a cytopathic effect at >= 1:8 were accepted as positive. @entity4 antibody was detected in 6 (12.2%) of 49 @entity0 by SNA and was statistically significant (p  <  0.05). @entity4 DNA was not detected in any of the adipose tissue samples of the @entity0 or control groups. Mean BMI and leptin levels were higher in the @entity4 -positive group, while adiponectin levels were found to be lower in the @entity4 -positive group. Although no statistically significant difference was found in @entity2 and @entity3 levels between the two groups (p  >  0.05), lower mean serum @entity2 and @entity3 levels were found in the @entity4 -positive @entity0 . In conclusion, we couldn't detect @entity4 DNA in adipose tissue; however, we detected significantly higher @entity4 antibody levels in the @entity1 group compared to the non- @entity1 group, according to the both univariant and multivariant analyses, suggesting that @entity4 may play a role in @entity1 . There is a need for new and extended serial, particularly cohort and @entity0 -based, studies in order to have a clear understanding of the @entity4 relationship.

title: The role of adenovirus 36 as a risk factor in XXXX : The first clinical study made in the fatty tissues of adults in Turkey.

answer: @entity1


abstract: BACKGROUND: The deaths of American hip-hop and @entity6 recording artists often receive considerable media attention. However, these artists' deaths have not been examined as a distinct group like the deaths of rock, classical, jazz, and pop music artists. This is a seminal epidemiological analysis on the deaths of an understudied group, American hip-hop and @entity6 music recording artists. METHODS: Media reports were analyzed of the deaths of American hip-hop and @entity6 music recording artists that occurred from January 1, 1987 to December 31, 2014. The decedents' age, sex, race, cause of @entity4 , stage names, and city and state of @entity4 were recorded for analysis. RESULTS: The most commonly reported cause of @entity4 was homicide. The 280 deaths were categorized as homicide (55%), @entity2 (13%), cardiovascular (7%), undetermined/undisclosed (7%), @entity1 (6%), other (5%), suicide (4%), and @entity3 (3%). The mean reported age at @entity4 was 30 yrs (range 15-75) and the median was 29 yrs; 97% were male and 92% were black. All but one of the homicides were committed with firearms. CONCLUSIONS: Homicide was the most commonly reported cause of @entity4 . Public health focus and guidance for @entity6 recording artists should mirror that for African-American @entity0 and adolescent males ages 15-54 yrs, for whom the leading causes of @entity4 are homicide, @entity2 , and @entity5 . Given the preponderance of homicide deaths in this analysis, premature mortality reduction efforts should focus on violence prevention and conflict mitigation.

title: Mortality in American Hip-Hop and XXXX Recording Artists, 1987-2014.

answer: @entity6


abstract: The dietary inflammatory index (DII) is a new tool to assess the inflammatory potential of the diet. In the present study, we aimed to determine the association between the DII and BMI, waist circumference and waist:height ratio (WHtR). We conducted a cross-sectional study of 7236 @entity0 recruited into the PREvenci  n con DIeta MEDiterr  nea trial. Information from a validated 137-item FFQ was used to calculate energy, food and nutrient intakes. A fourteen-item dietary screener was used to assess adherence to the Mediterranean diet (MeDiet). Sex-specific multivariable linear regression models were fitted to estimate differences (and 95 % CI) in BMI, waist circumference and WHtR across the quintiles of the DII. All nutrient intakes, healthy foods and adherence to the MeDiet were higher in the quintile with the lowest DII score (more anti-inflammatory values) except for intakes of animal protein, saturated fat and monounsaturated fat. Although an inverse association between the DII and total energy was apparent, the DII was associated with higher average BMI, waist circumference and WHtR after adjusting for known risk factors. The adjusted difference in the WHtR for @entity0 and @entity0 between the highest and lowest quintiles of the DII was 1  60 % (95 % CI 0  87, 2  33) and 1  04 % (95 % CI 0  35, 1  74), respectively. Pro-inflammatory scores remained associated with @entity1 after controlling for the effect that adherence to a MeDiet had on @entity2 . In conclusion, the present study shows a direct association between the DII and indices of @entity1 , and supports the hypothesis that diet may have a role in the development of @entity1 through inflammatory modulation mechanisms.

title: Dietary inflammatory index and anthropometric measures of XXXX in a population sample at high cardiovascular risk from the PREDIMED (PREvenci  n con DIeta MEDiterr  nea) trial.

answer: @entity1


abstract: OBJECTIVE: The precise etiology of @entity1 ( @entity1 ) is still unknown although dysregulation of apoptosis likely plays an important role in this pathogenesis. However, the significance of @entity3 -cell apoptosis in @entity2 ( @entity2 ) is unclear. In the present work we investigated the role of @entity4 ( @entity4 ), which is implicated in various @entity0 disorders. @entity0 AND METHODS: Results from a total of 393 @entity2 @entity0 and 1292 healthy individuals were analyzed in this study. We determined the three single nucleotide polymorphisms of @entity4 in 3' untranslated regions (UTR), and examined the plasma soluble @entity4 (sTRAIL) levels by enzyme-linked immunosorbent assay. RESULTS: We found that the mutant genotypes of @entity4 ( @entity6 / @entity7 / @entity5 and @entity6 and @entity7 ) were much lower in @entity2 @entity0 compared to the controls. Furthermore, mutant allele and genotype of @entity4 @entity5 were more prevalent in severe @entity2 @entity0 than in other @entity0 (p < 0.001; p = 0.005, respectively). The three polymorphic sites in 3'UTR were in a perfect linkage disequilibrium in our study. In contrast to controls, the GAT haplotype was increased (p < 0.001), while the AAT haplotype was decreased in @entity2 @entity0 (p < 0.001). Besides, the plasma levels of sTRAIL were significantly higher in @entity2 @entity0 than in controls (p < 0.001). CONCLUSIONS: Our findings suggested that increased occurrence of the genetic mutations of @entity4 in 3'UTR and possibly decreased plasma levels of sTRAIL might lead to a lower risk of @entity2 attack in Chinese @entity0 .

title: Association of XXXX with TNF-related apoptosis inducing ligand ( @entity4 ) gene polymorphisms and plasma soluble @entity4 levels in Chinese Han population.

answer: @entity2


abstract: OBJECTIVE: The precise etiology of @entity1 ( @entity1 ) is still unknown although dysregulation of apoptosis likely plays an important role in this pathogenesis. However, the significance of @entity3 -cell apoptosis in @entity2 ( @entity2 ) is unclear. In the present work we investigated the role of @entity4 ( @entity4 ), which is implicated in various @entity0 disorders. @entity0 AND METHODS: Results from a total of 393 @entity2 @entity0 and 1292 healthy individuals were analyzed in this study. We determined the three single nucleotide polymorphisms of @entity4 in 3' untranslated regions (UTR), and examined the plasma soluble @entity4 (sTRAIL) levels by enzyme-linked immunosorbent assay. RESULTS: We found that the mutant genotypes of @entity4 ( @entity6 / @entity7 / @entity5 and @entity6 and @entity7 ) were much lower in @entity2 @entity0 compared to the controls. Furthermore, mutant allele and genotype of @entity4 @entity5 were more prevalent in severe @entity2 @entity0 than in other @entity0 (p < 0.001; p = 0.005, respectively). The three polymorphic sites in 3'UTR were in a perfect linkage disequilibrium in our study. In contrast to controls, the GAT haplotype was increased (p < 0.001), while the AAT haplotype was decreased in @entity2 @entity0 (p < 0.001). Besides, the plasma levels of sTRAIL were significantly higher in @entity2 @entity0 than in controls (p < 0.001). CONCLUSIONS: Our findings suggested that increased occurrence of the genetic mutations of @entity4 in 3'UTR and possibly decreased plasma levels of sTRAIL might lead to a lower risk of @entity2 attack in Chinese @entity0 .

title: Association of @entity2 with TNF-related apoptosis inducing ligand ( XXXX ) gene polymorphisms and plasma soluble @entity4 levels in Chinese Han population.

answer: @entity4


abstract: OBJECTIVE: The precise etiology of @entity1 ( @entity1 ) is still unknown although dysregulation of apoptosis likely plays an important role in this pathogenesis. However, the significance of @entity3 -cell apoptosis in @entity2 ( @entity2 ) is unclear. In the present work we investigated the role of @entity4 ( @entity4 ), which is implicated in various @entity0 disorders. @entity0 AND METHODS: Results from a total of 393 @entity2 @entity0 and 1292 healthy individuals were analyzed in this study. We determined the three single nucleotide polymorphisms of @entity4 in 3' untranslated regions (UTR), and examined the plasma soluble @entity4 (sTRAIL) levels by enzyme-linked immunosorbent assay. RESULTS: We found that the mutant genotypes of @entity4 ( @entity6 / @entity7 / @entity5 and @entity6 and @entity7 ) were much lower in @entity2 @entity0 compared to the controls. Furthermore, mutant allele and genotype of @entity4 @entity5 were more prevalent in severe @entity2 @entity0 than in other @entity0 (p < 0.001; p = 0.005, respectively). The three polymorphic sites in 3'UTR were in a perfect linkage disequilibrium in our study. In contrast to controls, the GAT haplotype was increased (p < 0.001), while the AAT haplotype was decreased in @entity2 @entity0 (p < 0.001). Besides, the plasma levels of sTRAIL were significantly higher in @entity2 @entity0 than in controls (p < 0.001). CONCLUSIONS: Our findings suggested that increased occurrence of the genetic mutations of @entity4 in 3'UTR and possibly decreased plasma levels of sTRAIL might lead to a lower risk of @entity2 attack in Chinese @entity0 .

title: Association of @entity2 with TNF-related apoptosis inducing ligand ( @entity4 ) gene polymorphisms and plasma soluble XXXX levels in Chinese Han population.

answer: @entity4


abstract: OBJECTIVE: This study was conducted in order to investigate the effects of @entity11 -induced @entity3 ( @entity3 ) on renal blood flow and biochemical changes in @entity1 , and to assess the effect of treatment with gum acacia (GA) thereon. MATERIALS AND METHODS: @entity3 was induced by feeding @entity1 with @entity11 (0.25% w/w, five weeks). Concomitantly, some of these @entity1 were also given gum acacia (GA) (15% w/v in the drinking water).   Before animals were sacrificed, changes in renal blood flow (RBF) were monitored in anaesthetized @entity1 preparations. Several biochemical and histological renal function tests were also conducted. RESULTS: @entity11 -induced @entity3 significantly impaired the vasopressor actions of @entity4 , @entity8 and @entity9 and concomitant treatment with GA abated these responses. Additionally,   plasma concentrations of @entity6 , @entity5 , @entity2 , @entity12 , @entity10 and @entity7 and urinary excretion of protein were all significantly increased by @entity11 . GA significantly mitigated the severity of @entity11 - induced changes. CONCLUSIONS: @entity11 -induced @entity3 in @entity1 significantly @entity0 responses to @entity4 , @entity8 and @entity9 and this was mitigated by treatment with GA. This provides another experimental evidence for the usefulness of GA in the amelioration of @entity3 .

title: Influence of treatment with gum acacia on renal vascular responses in a @entity1 model of XXXX .

answer: @entity3


abstract: OBJECTIVE: This study was conducted in order to investigate the effects of @entity11 -induced @entity3 ( @entity3 ) on renal blood flow and biochemical changes in @entity1 , and to assess the effect of treatment with gum acacia (GA) thereon. MATERIALS AND METHODS: @entity3 was induced by feeding @entity1 with @entity11 (0.25% w/w, five weeks). Concomitantly, some of these @entity1 were also given gum acacia (GA) (15% w/v in the drinking water).   Before animals were sacrificed, changes in renal blood flow (RBF) were monitored in anaesthetized @entity1 preparations. Several biochemical and histological renal function tests were also conducted. RESULTS: @entity11 -induced @entity3 significantly impaired the vasopressor actions of @entity4 , @entity8 and @entity9 and concomitant treatment with GA abated these responses. Additionally,   plasma concentrations of @entity6 , @entity5 , @entity2 , @entity12 , @entity10 and @entity7 and urinary excretion of protein were all significantly increased by @entity11 . GA significantly mitigated the severity of @entity11 - induced changes. CONCLUSIONS: @entity11 -induced @entity3 in @entity1 significantly @entity0 responses to @entity4 , @entity8 and @entity9 and this was mitigated by treatment with GA. This provides another experimental evidence for the usefulness of GA in the amelioration of @entity3 .

title: Influence of treatment with gum acacia on renal vascular responses in a XXXX model of @entity3 .

answer: @entity1


abstract: BACKGROUND CONTEXT: @entity4 occurring after percutaneous @entity5 has rarely been described. To date, only two such cases have been documented in the literature. @entity5 may reactivate a quiescent tuberculous lesion and promote the infective process in elderly @entity0 with or without immunosuppression, thereby resulting in poor outcomes. PURPOSE: The purposes of this study were to present two cases in which spinal @entity1 occurred after vertebroplasty or kyphoplasty, to highlight the clinical features and need for early diagnosis of this pathology, and to postulate probable reasons for this association. STUDY DESIGN: This study is based on a clinical case series and literature review. METHODS: In this report, we review the clinical histories of two old @entity0 undergoing @entity5 with subsequent spinal @entity1 . RESULTS: The first @entity0 responded favorably to conservative treatment with multidrug antitubercular therapy and spinal braces. The second @entity0 underwent surgical debridement through a posterior approach alone, without instrumentation, combined with adjuvant chemotherapy. By 1 year after treatment, both @entity0 had experienced almost complete recovery and continued to be seen for follow-up visits. CONCLUSIONS: Suspicion should be high, and magnetic resonance imaging is warranted in cases with deteriorating clinical symptoms and signs of @entity2 after @entity5 . We propose obtaining exhaustive microbiologic and histologic evidence via needle biopsy or open surgery in a timely fashion to establish an accurate diagnosis because @entity3 occurring in such a situation may progress rapidly.

title: @entity4 of the lumbar spine after percutaneous XXXX (vertebroplasty or kyphoplasty).

answer: @entity5


abstract: BACKGROUND CONTEXT: @entity4 occurring after percutaneous @entity5 has rarely been described. To date, only two such cases have been documented in the literature. @entity5 may reactivate a quiescent tuberculous lesion and promote the infective process in elderly @entity0 with or without immunosuppression, thereby resulting in poor outcomes. PURPOSE: The purposes of this study were to present two cases in which spinal @entity1 occurred after vertebroplasty or kyphoplasty, to highlight the clinical features and need for early diagnosis of this pathology, and to postulate probable reasons for this association. STUDY DESIGN: This study is based on a clinical case series and literature review. METHODS: In this report, we review the clinical histories of two old @entity0 undergoing @entity5 with subsequent spinal @entity1 . RESULTS: The first @entity0 responded favorably to conservative treatment with multidrug antitubercular therapy and spinal braces. The second @entity0 underwent surgical debridement through a posterior approach alone, without instrumentation, combined with adjuvant chemotherapy. By 1 year after treatment, both @entity0 had experienced almost complete recovery and continued to be seen for follow-up visits. CONCLUSIONS: Suspicion should be high, and magnetic resonance imaging is warranted in cases with deteriorating clinical symptoms and signs of @entity2 after @entity5 . We propose obtaining exhaustive microbiologic and histologic evidence via needle biopsy or open surgery in a timely fashion to establish an accurate diagnosis because @entity3 occurring in such a situation may progress rapidly.

title: XXXX of the lumbar spine after percutaneous @entity5 (vertebroplasty or kyphoplasty).

answer: @entity4


abstract: INTRODUCTION: @entity4 use increases the risk of mortality, @entity1 and @entity2 in transplanted @entity0 . Transplanted @entity0 are encouraged to quit @entity4 use before and after renal transplantation. This study was carried out to evaluate the prevalence of @entity4 consumption in transplanted @entity0 in one French region. This survey was also conducted to identify factors associated with failure in smoking cessation. MATERIALS AND METHOD: A questionnaire was sent by mail to transplanted @entity0 followed in our center between the 1/01/95 and the 31/12/10. A second mail was sent to increase the response rate. RESULTS: During the study period, 544  questionnaires were sent to kidney transplant recipients. Among these 544  @entity0 , there were 362  responders. Of these 362  @entity0 , 121  @entity0 (33.4%) were past smokers, and 21 (5.8%) were active smokers. Among the smokers, 20% were exposed to second-hand smoke, 48% had criteria for @entity4 moderate to high dependency, and 13.4% were addicted to @entity3 . In the multivariate analysis, exposure to second-hand smoke and living alone at home were associated with failure in smoking cessation. CONCLUSION: This study shows that the prevalence of @entity4 use is not high in transplanted @entity0 . Only 6% of our @entity0 report @entity4 use at the study time. Environmental factors are associated with failure in @entity4 cessation. Living alone and exposure to second-hand smoke are associated with smoking. Therefore, in transplantation centers, programs devoted to @entity4 cessation should be implemented and should take care of @entity0 ' lifestyle.

title: [PRETAGREF study: Prevalence of XXXX use and factors associated with smoking cessation in kidney transplant recipients].

answer: @entity4


abstract: UNASSIGNED: Autophagy is an intracellular process leading to vacuolar or lysosomal degradation of cytoplasmic components in eukaryotes. Establishment of proper methods to monitor autophagy was a key step to uncover its role in organisms such as @entity0 , mammals and @entity2 , in which chloroplastic proteins were found to be recycled by autophagy. Chloroplast recycling has been predicted to function in nutrient remobilization for growing organs or grain filling in cereal crops. Here, to develop our understanding of autophagy in cereals, we established monitoring methods for chloroplast autophagy in @entity1 ( @entity1 ). We generated transgenic @entity1 expressing fluorescent protein (FP)-OsATG8 fusions as autophagy markers. FP-ATG8 signals were delivered into the vacuolar lumen in living cells of roots and leaves mainly as vesicles corresponding autophagic bodies. This phenomenon was not observed upon the addition of @entity4 , an inhibitor of autophagy, or in an AUTOPHAGY7 knockout mutant. Markers for the chloroplast stroma, stromal FP and FP-labeled Rubisco, were delivered via a type of autophagic body called the @entity3 ( @entity3 ) in the same manner. @entity3 production in excised leaves was suppressed by supply of external Suc or light. The release of free FP due to autophagy-dependent breakdown of FP-labeled Rubisco was induced during accelerated senescence in individually-darkened leaves. In roots, non-green plastids underwent both @entity3 -mediated and entire-organelle types of autophagy. Therefore, our newly developed methods to monitor autophagy directly demonstrated autophagic degradation of leaf chloroplasts and root plastids in @entity1 plants and its induction during energy limitation.

title: Establishment of monitoring methods for autophagy in XXXX reveals autophagic recycling of chloroplasts and root plastids during energy limitation.

answer: @entity1


abstract: This is a report of the third in a series of experiments carried out to identify and to determine the reliability of atrial pacemakers below the sinoatrial (SA) node. This information could be useful to the surgeon in planning both corrective atrial operations and direct operations for @entity1 . In this study, done in @entity0 , the @entity2 containing the atrioventricular (AV) node was completely separated from the remaining atria. Seven @entity0 survived for 35 to 116 days. Serial electrocardiograms (ECGs) after operation showed that four of the seven @entity0 developed a regular junctional rhythm with a rate of 85 beats/min, whereas three of seven developed an irregular junctional rhythm with pauses and bigeminy. In a control study, in which the AV node was disconnected from the His bundle, a slow regular junctional rhythm was produced in all three of the @entity0 . Thus, in the series of three experiments, this being the report of the last one, a hierarchy of pacemakers below the SA node was identified. The first one, a pacemaker in the low right atrium in the region of the coronary sinus, was the most reliable and was associated with a normal ECG. A second, in the @entity2 , did not develop dominance in all @entity0 . However, the junctional pacemaker in the His bundle always became dominant after the AV node was disconnected from the His bundle and was associated with a regular but slow rhythm.

title: Surgical isolation of the XXXX from the atria. Identification of an atrial septal pacemaker.

answer: @entity2


abstract: The clinical, laboratory and pathologic findings were studied in 62 consecutively autopsied @entity0 with @entity11 between 1954 and 1975. All @entity0 were 40 years of age or older. Bone @entity1 was the initial symptom in 2/3 of @entity0 . @entity6 (81%), @entity9 (29%), @entity13 (41%), @entity14 (46%) and @entity17 (52%), were common laboratory findings at diagnosis. Ninety-seven percent had a monoclonal protein in serum or urine. Extensive plasma cell replacement of marrow was invariably seen at autopsy although in 15% of @entity0 no abnormality was found on skeletal survey. Extraskeletal spread (67%) was due to direct extension to paraosseous tissue resulting from cortical destruction and to distant organ involvement mainly of splenic red pulp and hepatic sinusoids. The @entity0 were susceptible to @entity12 , mainly gram-negative, of the lung (56%), urinary tract (35%), and blood (24%). @entity5 was less frequent and usually consisted of superficial candidal overgrowth of gastrointestinal tract @entity10 (18%). @entity15 (10%) was perivascular and associated with light chain @entity8 . @entity2 as a cause of @entity3 (21%) was secondary only to @entity4 (52%). Severity of histologic findings in the kidney at autopsy had little correlation to initial BUN concentration. The median survival was 11.5 months with alkylating agent therapy (responders, 29 months; non-responders, 6 months), and 6 months with @entity16 . Initial @entity13 (greater than 80 mg/dl) and @entity14 (greater than 12 mg/dl) were important prognostic indicators (median survival, less than 1 month and 3 months, respectively). A good response to alkylating agent therapy, initial BUN less than 40 mg/dl and serum @entity7 less than 12 mg/dl were favorable to prognostic indicators.

title: XXXX : a clinicopathologic study of 62 consecutively autopsied cases.

answer: @entity11


abstract: AIM: Comparing the different possible surgical procedures and the results in urgent/emergency and in elective surgery for obstructing @entity2 . MATERIAL OF STUDY: From 2008 we operated on 238 @entity0 affected by @entity2 , 115 obstructing and 19 perforated. 23 @entity0 had right-sided and 92 left-sided obstructing @entity1 , divided retrospectively in 4 groups. 18 decompressive colostomy; 32 two-stages procedures: 25 Hartmann's operations and 7 total colectomies with terminal ileostomy; 7 one-stage procedures, with defunctioning ileostomy: 4 total colectomies and 3 colonic resections with wash-out; 35 one-stage procedures with primary @entity4 +wash-out or milking. RESULTS: Operative mortality is 7% in urgent/emergency versus 1% in elective surgery and anastomotic leakage affected 6 /58 cases, 5 requiring additional surgery. Overall, about 2/3 of the perioperative @entity3 were related to general complications and 1/3 to anastomotic failure. The local recurrence rate was 7% in elective and 11% in urgent/emergency surgery. DISCUSSION AND CONCLUSIONS: Obstructing @entity2 is associated with a high operative mortality and a worse prognosis, in terms of recurrence and survival. Actually, immediate resection with primary @entity4 represents the goldstandard in selected @entity0 with a low anaesthetic risk, performing either as a typical resection with wash-out, or a subtotal colectomy; a temporary defunctioning colostomy or ileostomy could be proposed for @entity0 with an intermediate risk; in high-risk cases, advanced obstruction, simultaneous @entity5 , metastatic or locally advanced disease, Hartmann's operation should be used, as a safer procedure. Colon stenting can be an useful palliative or bridge-to-surgery option. KEY WORDS: Bowel obstruction, @entity2 , Primary @entity4 .

title: Our experience in the management of obstructing XXXX .

answer: @entity2


abstract: BACKGROUND: @entity1 ( @entity1 ) is a progressive disease, leading to substantial physical impairment. The distance walked in 6 min (6MWD) is a measure of exercise tolerance and is of prognostic relevance in @entity1 . While 6MWD is a punctual measurement which may not be representative, self-reported daily life activity may represent the @entity0 ' functional capacity more globally even in less severe affected @entity0 . OBJECTIVES: We evaluated and characterized a simple classification system based on the @entity0 ' self-reported daily activity and analyzed if this would add significantly to the prognostic information of the 6MWD alone in @entity1 @entity0 . METHODS: Daily life activity was assessed in @entity1 (n = 156) @entity0 with standardized questions and categorized in activity classes (AC I-IV), comprising the less severe impaired in AC I and II. The 6MWD was also assessed. RESULTS: ACs were related to the lung functional impairment and inversely correlated to the 6MWD. Thirty-two @entity0 were in AC I/II, 98 in @entity2 and 26 @entity0 in AC IV. Thirty-seven (23.7%) @entity0 died during a median follow-up of 14.9 months, comprising 1 @entity0 in AC I/II. In addition, a 6MWD <470 m predicted mortality. Combining AC I/II and a 6MWD >470 m identified a subgroup of @entity0 with favorable outcome. CONCLUSIONS: AC is a novel scoring system which can easily be obtained and correlates with lung functional and physical impairments as well as mortality. Moreover, AC adds prognostic information to the 6MWD.

title: Self-Report Daily Life Activity as a Prognostic Marker of XXXX .

answer: @entity1


abstract: UNASSIGNED: The leaf surface usually stays flat, maintained by coordinated growth. Growth perturbation can introduce overall surface curvature, which can be negative, giving a saddle-shaped leaf, or positive, giving a cup-like leaf. Little is known about the molecular mechanisms that underlie @entity2 , primarily because only a few mutants with altered surface curvature have been isolated and studied. Characterization of mutants of the CINCINNATA-like @entity3 genes in Antirrhinum and @entity0 have revealed that their products help maintain @entity2 by balancing the pattern of cell proliferation and surface expansion between the margin and the central zone during leaf morphogenesis. On the other hand, deletion of two homologous PEAPOD genes causes cup-shaped leaves in @entity0 due to excess division of dispersed meristemoid cells. Here, we report the isolation and characterization of an @entity0 mutant, tarani (tni), with enlarged, cup-shaped leaves. Morphometric analyses showed that the positive curvature of the tni leaf is linked to excess growth at the centre compared to the margin. By monitoring the dynamic pattern of CYCLIN D3;2 expression, we show that the shape of the primary arrest front is strongly convex in growing tni leaves, leading to excess mitotic expansion synchronized with excess cell proliferation at the centre. Reduction of cell proliferation and of endogenous @entity1 levels rescued the tni phenotype. Genetic interactions demonstrated that TNI maintains @entity2 independent of TCPs and PEAPODs.

title: The tarani mutation alters surface curvature in XXXX leaves by perturbing the patterns of surface expansion and cell division.

answer: @entity0


abstract: Twenty-seven crosses derived from three random-mating, unselected strains of @entity0 (SWO, J, PGH) with 16 matings/pureline or cross were cohabited continuously and monogamously for 365 d to evaluate long-term reproductive performance of the parents. Data from 3,249 litters born were analyzed to study the effects of parity (number of litters) and type of cross (pureline, two-way, backcross, three-way) on the following traits: 1) continuity of reproduction ( @entity1 ), 2) litter size at birth (LSB), 3) age at first litter (AFL), 4) fraction alive at birth-the ratio of number born alive to LSB (FAB), 5) birth to birth interval (BBI) and 6) reproductive rate-the ratio of number born alive to birth to birth interval (RRT). Reproductive rate was also studied in a cumulative manner rather than on a per parity basis by regressing cumulative number born alive on cumulative birth to birth interval. Parity effects were important (P less than .01) for all traits measured. Differences among cross-types were highly significant for @entity1 , LSB and RRT. Three-way crosses were more productive than backcrosses, and both were superior to two-way and pureline matings. Uniformity was greater among three-way crosses for all traits except @entity1 . Cross-types differed importantly in the pattern of change in performance over parities for @entity1 , LSB, FAB, RRT and cumulative number of live young (P less than .01). Number of parities were most important for variation in longevity of reproduction ( @entity1 ) and somewhat for litter size (LSB). Mean and cumulative reproductive rates were influenced more by longevity and litter size than by interval between births.

title: Lifetime parental productivity in twenty-seven crosses of XXXX . I. Birth traits.

answer: @entity0


abstract: BACKGROUND: @entity5 ( @entity5 ) has become a major health problem in Sub Saharan Africa (SSA). There were limited data about causes of @entity5 in the Sudan. METHODS: This is a cross sectional hospital based descriptive study. The subjects of the study are @entity5 adults' @entity0 on regular haemodialysis treatment in 15 haemdoialysis centres in Khartoum State-Sudan. Clinical and epidemiological data were obtained from 1583 @entity0 . The medical files of each @entity0 were reviewed to identify the cause of @entity5 . Concerning the causes of @entity5 , @entity1 was diagnosed based on the past medical history and result of the @entity4 tolerance test, @entity3 was diagnosed based on past history of @entity3 based on blood pressure of more than 140/90  mmHg, @entity6 was diagnosed based on results of previous kidney biopsies and on clinical grounds, @entity2 and obstructive @entity9 were diagnosed based on abdominal ultrasound and other imaging modalities, sickle cell anaemia was diagnosed based on the result of haemoglobin electrophoresis, @entity7 was diagnosed based on the clinical criteria in addition to lab results of auto antibodies, and analgesic @entity2 was diagnosed based on past medical history of chronic analgesic drugs usage with no other identifiable risk factors. We included all @entity5 @entity0 on regular haemodialysis treatment. We excluded @entity5 @entity0 less than 18  years old. RESULTS: The results showed that the mean age of @entity5 @entity0 was 49      15.8 (years) and 63.4  % were male and 76.3  % were unemployed. The mean duration of haemodialysis is 4.38      4.24 (years). The most common cause of @entity5 in our @entity0 was @entity3 (34.6  %) followed by chronic @entity6 (17.6  %), @entity1 (12.8  %), obstructive @entity9 (9.6  %), @entity2 ( @entity2 ) (4.7  %), chronic @entity8 (4.6  %), analgesic @entity2 (3.5  %). However in (10.7  %) no cause was found. In @entity0 aged less than 40  years old the leading cause of @entity5 was @entity6 (29.3  %) followed by @entity3 (25  %). In @entity0 aged between 40 to 60  years old the leading cause of @entity5 was @entity3 (38.5  %) followed by @entity1 (14  %). In @entity0 aged older than 60  years the leading cause of @entity5 was @entity3 (38.4  %) followed by @entity1 (23.3  %). CONCLUSIONS: @entity5 in Sudan affects the economically productive age group; unemployment rate among @entity5 @entity0 is high. The study showed that @entity3 is a leading cause of @entity5 in Sudan followed by chronic @entity6 . @entity3 and @entity1 are the leading causes of @entity5 among @entity0 over 40  years old.

title: Causes of end stage renal failure among haemodialysis XXXX in Khartoum State/Sudan.

answer: @entity0


abstract: UNASSIGNED: To analyze the intraocular pressure reduction, number of anti- @entity2 medications needed, and post-operative complications of trans-scleral diode laser cyclophotocoagulation (DCPC) in @entity0 with high-risk penetrating keratoplasty (PKP) and secondary refractory @entity2 . Prospective interventional, longitudinal, non-comparative series of cases, including 16 eyes of 15 @entity0 's post-PKP on maximal anti- @entity2 medical therapy with intraocular pressures above 22  mmHg. All @entity0 received 18 shots, 360   peri-limbal (avoiding the long posterior ciliary nerves and arteries at 3 and 9 o'clock positions) of trans-scleral DCPC (2000  mW, time: 2.0  s/shot). There was a 55.5  % reduction (total of 14.0  mmHg) of the mean pre-operative IOP (31.5  mmHg) after the first diode laser application (p  =  0.0020). Re-treatment was required in 31.2  % of eyes over a mean period of 10.7  months. In these five eyes, the mean pre-operative IOP was 40.4  mmHg, which decreased to 15.0  mmHg post-therapy, and a mean IOP reduction of 25.4  mmHg (p  =  0.0218). There was a 51.0  % reduction in the mean number of medications used after the first, and a 57.1  % reduction after a second laser application. The incidence of failure (IOP  >=   22  mmHg or need of additional medical therapy) from initial intervention to loss of follow-up was 1.3  % per @entity0 -month. DCPC effectively reduces the intraocular pressure and the number of anti- @entity2 medications with few complications in @entity0 after high-risk PKP and @entity2 . Only, one-third of the eyes needed a second intervention to control the intraocular pressure. Post-DCPC complications were limited to phthisis bulbi and @entity1 , one eye each. Please check and confirm the author names and initials are correct. Also, kindly confirm the details in the metadata are correct.

title: Trans-scleral diode laser cyclophotocoagulation for refractory XXXX after high-risk penetrating keratoplasty.

answer: @entity2


abstract: UNASSIGNED: The quadriceps femoris (QF) muscle group plays an essential role in @entity0 movement, such as standing, walking and running. The ability to maintain a steady force during physical activity of the @entity0 lower limb is important for mobility, postural control and balance. Although prolonged mechanical vibration of the muscle-tendon unit can moderate the efficacy of synaptic input from Ia afferent onto the a-motor neuron pathway, the effect of prolonged tendon vibration on fluctuations of knee extensor force has received little attention. The purpose of the present study was to examine the effects of @entity1 on the force steadiness of the QF muscle. Nine healthy @entity0 performed a submaximal force-matching task involving isometric knee extension before and after patellar tendon vibration or quiet seated rest (n  =  7, control condition) for 30  min. The target force was 2.5, 10 and 30  % of maximal @entity2 (MVC). Surface electromyography (EMG) of the four QF synergists was recorded and normalized to EMG amplitude during the MVC. The knee extension force and the EMG amplitude of vastus medialis during the MVC were significantly reduced after the vibration, but did not significantly decrease in the control condition. Fluctuations of force and normalized EMG of individual QF muscles at each submaximal force level did not significantly change after the vibration. We conclude that @entity1 does not influence the force steadiness of the QF muscle during an isometric force-matching task.

title: Effects of XXXX in quadriceps femoris during force-matching task.

answer: @entity1


abstract: OBJECTIVES: To evaluate the health outcomes and economics associated with the current guidance relating to the prevention of falls in the elderly through @entity2 supplementation. SETTING: UK. @entity0 : UK population aged 60   years and above. INTERVENTIONS: A Markov health state transition model simulated @entity0 transitions between key fall-related outcomes using a 5-year horizon and annual cycles to assess the costs and benefits of empirical treatment with @entity3 800   iu daily. PRIMARY AND SECONDARY OUTCOME MEASURES: Costs and health outcomes attributable to fall prevention following @entity2 supplementation. RESULTS: Our model shows that treating the UK population aged 60   years and above with 800   iu @entity3 would, over a 5-year period: (1) prevent in excess of 430   000 minor falls; (2) avoid 190   000 major falls; (3) prevent 1579 acute @entity1 ; (4) avoid 84   000 @entity0 -years of long-term care and (5) prevent 8300 @entity1 associated with increased mortality in long-term care. The greatest gains are seen among those 75   years and older. Based on reduction in falls alone, the intervention in all adults aged 65+ is cost-saving and leads to increased quality adjusted life years. Treating all adults aged 60+ incurs an intervention cost of   2.70bn over 5   years, yet produces a -  3.12bn reduction in fall-related costs; a net saving of   420M. Increasing the lower bound age limit by 5-year increments increases budget impact to -  1.17bn, -  1.75bn, and -  2.06bn for adults 65+, 70+ and 75+, respectively. CONCLUSIONS: This study shows that treatment of the elderly UK population with @entity3 800   iu daily would be associated with reductions in mortality and substantial cost-savings through fall prevention.

title: Cost-effectiveness and budget impact of Empirical XXXX therapy on unintentional falls in older adults in the UK.

answer: @entity2


abstract: BACKGROUND: @entity2 and @entity1 in childhood are related to early @entity3 , as @entity7 . Few studies have analyzed the independent effects of @entity2 and weight excess on diastolic function and left ventricular geometry. OBJECTIVE: We studied the effects of weight, waist circumference (as an index of fat distribution) and blood pressure on left ventricular mass index, the risk of @entity7 , diastolic function and left ventricular geometry in 526 @entity0 (237 @entity0 , age range 6-15 years). METHODS: @entity0 were divided into normotensive, prehypertensive and @entity2 (US Nomograms) groups, and into normal-weight, overweight, and @entity1 (International @entity1 Task Force classification) groups. Left ventricular mass index, diastolic function and left ventricular geometry were assessed. RESULTS: @entity8 z-scores and blood pressure categories significantly influenced cardiac mass (P<0.001 and P=0.02, respectively) and the prevalence of @entity7 (P<0.001 and P<0.05, respectively). @entity1 , BMI, and waist circumference z-scores were significantly associated with an increment in E/Em ratio (P<0.001, P<0.01, and P<0.01, respectively). Increasing blood pressure values and the presence of @entity6 (P<0.05) and @entity2 (P<0.003), but not weight excess, were associated with @entity3 . In contrast, concentric @entity4 was associated with @entity2 (P<0.01), @entity1 (P<0.001), and increasing waist circumference (P<001). CONCLUSIONS: Blood pressure values and @entity2 are independently associated with an increase of cardiac mass and the presence of @entity5 . @entity1 and waist circumference, but not @entity2 , are associated with a worsening of diastolic function, whereas only @entity2 @entity0 show high prevalence of concentric remodeling. Blood pressure and body weight and fat distribution have an independent and different impact on left ventricular structure and function in @entity0 .

title: The role of blood pressure, body weight and fat distribution on left ventricular mass, diastolic function and cardiac geometry in XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity4 ( @entity4 ) and drug seeking share similar behavioral features, including loss of control over consumption and compulsive seeking of the craved substance. Previous studies in animal models have demonstrated a complex interaction between 'state' @entity4 , produced by intermittent access to a palatable diet, and 'trait' @entity4 , a phenotypical proneness towards overeating. In the present study, we examined the relationship between state and trait @entity4 and @entity3 seeking. We used Otsuka Long Evans Tokushima Fatty @entity1 , a genetic model for @entity0 that demonstrates @entity4 -like behavior, and Long Evans Tokushima Otsuka controls. They received a schedule of limited access to a palatable diet (3   days/week or 5   days/week access to Ensure for a month). Next, they underwent @entity3 self-administration training (1   mg/kg, 1   hour/day for 10   days) followed by extinction sessions (7   days). We found that the degree of @entity4 -like behavior and the state and trait @entity4 combination predicted @entity3 craving patterns. Lower levels of @entity2 D2 receptors in the prefrontal cortex were correlated with increased drug craving. Moreover, restricted access to an attractive diet was found to be a risk factor for heightened @entity3 craving, particularly in trait binge eaters, as @entity1 on the 3   days/week access schedule persistently failed to cease @entity3 seeking throughout extinction. Hence, we postulate a joint role of state and trait @entity4 as risk factors for heightened @entity3 craving.

title: Trait and state binge eating predispose towards XXXX craving.

answer: @entity3


abstract: AIM: The aim of this study was to identify the influence of oocyte @entity2 on clinical outcomes after intracytoplasmic sperm injection cycle in normal responders. MATERIAL AND METHODS: In the prospective study, morphology of 1999 metaphase II oocytes retrieved from 316 intracytoplasmic sperm injection cycles was evaluated from March 2011 to March 2013 at Royan Institute. Controlled ovarian stimulation was performed by long standard agonist protocol. Oocyte morphology was assessed before sperm injection by one embryologist. The associations between fertilization rate, embryo quality and the independent variables were analyzed using odds ratio (OR) calculated with unconditional logistic regression test. RESULTS: From all retrieved oocytes, 1543 (77.1%) showed at least one morphologic aberration. Presence of cytoplasmic vacuoles and high cytoplasmic viscosity were associated with a significant decrease in the fertilization rate (OR: 0.5; P   =   0.004 and OR: 0.6; P   =   0.03, respectively). The results showed that oocyte morphology did not affect embryo quality. The number of gonadotrophin injections used showed a direct relation with presence of large perivitelline space. No significant difference was observed among four groups ( @entity0 with total normal morphologic oocytes [group 1], @entity0 with total extracytoplasmic dysmorphic oocytes [group 2], @entity0 with total cytoplasmic dysmorphic oocytes [group 3] and @entity0 with total oocytes containing multiple @entity1 [group 4]) in terms of implantation and clinical pregnancy rates. CONCLUSIONS: Metaphase II oocyte morphology had minor impacts on fertilization rate, pronuclear morphology and embryo quality in @entity0 with normal ovarian response.

title: Effect of oocyte XXXX on intracytoplasmic sperm injection cycle outcomes in normal ovarian responders.

answer: @entity2


abstract: BACKGROUND: Inhaled @entity2 have been studied for both prevention and treatment of @entity4 ( @entity4 ). Results have been inconsistent. Recently, a large @entity1 ( @entity1 ) has been reported. METHODS/DESIGN: We will perform a comprehensive systematic literature search for randomized and quasi-randomized controlled trials that studied the efficacy and safety of inhaled @entity3 administered to preterm @entity0 (22-36  weeks) for either the prevention or treatment of @entity4 diagnosed by both clinical and physiological outcome criteria. We will assess potential risk of bias for each @entity1 meeting our selection criteria using the Cochrane risk of bias tool for RCTs. The primary outcome of interest will be mortality or @entity4 or both at 28  days postnatal age or 36  weeks postmenstrual age. Pooled estimates will be calculated using RevMan software with a random effects model as primary analysis. We will assess the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. DISCUSSION: Meta-analytic estimates of eligible RCTs, potentially including a new large @entity1 , may significantly influence neonatal practice in the prevention and treatment of respiratory problems in preterm @entity0 . SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015019628.

title: Use of inhaled XXXX for the prevention and/or treatment of @entity4 in preterm @entity0 : a systematic review protocol.

answer: @entity3


abstract: BACKGROUND: Inhaled @entity2 have been studied for both prevention and treatment of @entity4 ( @entity4 ). Results have been inconsistent. Recently, a large @entity1 ( @entity1 ) has been reported. METHODS/DESIGN: We will perform a comprehensive systematic literature search for randomized and quasi-randomized controlled trials that studied the efficacy and safety of inhaled @entity3 administered to preterm @entity0 (22-36  weeks) for either the prevention or treatment of @entity4 diagnosed by both clinical and physiological outcome criteria. We will assess potential risk of bias for each @entity1 meeting our selection criteria using the Cochrane risk of bias tool for RCTs. The primary outcome of interest will be mortality or @entity4 or both at 28  days postnatal age or 36  weeks postmenstrual age. Pooled estimates will be calculated using RevMan software with a random effects model as primary analysis. We will assess the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. DISCUSSION: Meta-analytic estimates of eligible RCTs, potentially including a new large @entity1 , may significantly influence neonatal practice in the prevention and treatment of respiratory problems in preterm @entity0 . SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015019628.

title: Use of inhaled @entity3 for the prevention and/or treatment of XXXX in preterm @entity0 : a systematic review protocol.

answer: @entity4


abstract: BACKGROUND: Inhaled @entity2 have been studied for both prevention and treatment of @entity4 ( @entity4 ). Results have been inconsistent. Recently, a large @entity1 ( @entity1 ) has been reported. METHODS/DESIGN: We will perform a comprehensive systematic literature search for randomized and quasi-randomized controlled trials that studied the efficacy and safety of inhaled @entity3 administered to preterm @entity0 (22-36  weeks) for either the prevention or treatment of @entity4 diagnosed by both clinical and physiological outcome criteria. We will assess potential risk of bias for each @entity1 meeting our selection criteria using the Cochrane risk of bias tool for RCTs. The primary outcome of interest will be mortality or @entity4 or both at 28  days postnatal age or 36  weeks postmenstrual age. Pooled estimates will be calculated using RevMan software with a random effects model as primary analysis. We will assess the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. DISCUSSION: Meta-analytic estimates of eligible RCTs, potentially including a new large @entity1 , may significantly influence neonatal practice in the prevention and treatment of respiratory problems in preterm @entity0 . SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015019628.

title: Use of inhaled @entity3 for the prevention and/or treatment of @entity4 in preterm XXXX : a systematic review protocol.

answer: @entity0


abstract: BACKGROUND: Percent time in therapeutic range (TTR) and international normalized ratio (INR) variability both measure @entity5 control and are associated with outcomes independently. Here, we examine the advantages of a @entity5 composite measure (WCM), which summarizes the 2 when measuring @entity0 outcomes. We also examine how the measure chosen would affect anticoagulation clinic performance rankings. METHODS AND RESULTS: We constructed WCM using an equally weighted method, adding standardized TTR to standardized log-transformed INR variability using 103 897 @entity5 -experienced @entity0 from 100 anticoagulation clinics. We examined the association of WCM with @entity2 , major @entity3 , and fatal @entity3 , using a subset of @entity0 with @entity4 (n=40 404). We divided @entity0 into quintiles based on their level of control for TTR, log INR variability, and WCM. We calculated the hazard ratios for @entity2 , major @entity3 , and fatal @entity3 stratified by these quintiles. WCM hazard ratios' for @entity1 and fatal @entity3 showed the largest difference between excellent control and poorest control quintile compared with TTR and log INR variability, but not for major @entity3 . In addition, we compared site rankings obtained using each of our 3 performance measures. Kappa scores for identifying outlier and nonoutlier clinics between WCM and its components were moderate (k=0.56 for TTR and k=0.62 for log INR variability) but was weak between TTR and log INR variability (k=0.13). CONCLUSIONS: WCM produces the largest range of risk for @entity5 complications, widening the floor ceiling effects that limit the use of TTR and INR variability as separate measures. Anticoagulation clinics ranking changed considerably according to the anticoagulation measure that was selected.

title: Improving Anticoagulation Measurement: Novel XXXX Composite Measure.

answer: @entity5


abstract: AIM: To evaluate the efficacy of @entity10 ( @entity11 ) as a chemotherapeutic agent for the treatment of @entity2 ( @entity2 ). METHODS: BALB/c @entity1 were randomized into four groups 24 h before subcutaneous injection of hepatocarcinoma BEL7402 cells suspended in @entity8 buffered saline (PBS) into the right flank. The control group (n = 10) was fed a standard diet while treatment groups (n = 10 each) were fed a standard daily diet supplemented with different concentrations of @entity11 (30, 50 and 70 mg/kg per day) for 21 d. @entity0 growth was measured once each week, and @entity0 volume (V) was calculated with the following equation: V = (L * W(2)) * 0.52, where L is the length and W is the width of the xenograft. After 21 d, @entity1 were killed under ether anesthesia, and @entity0 were excised and weighed. Apoptosis was evaluated through detection of DNA fragmentation with gel electrophoresis and the terminal deoxynucleotidyl transferase-mediated @entity7 - @entity6 nick end labeling (TUNEL) assay. Western blot analysis was performed to determine the expression of apoptosis-related proteins @entity5 , @entity4 , @entity12 , cleaved @entity9 , and cleaved @entity3 . RESULTS: @entity11 suppressed @entity0 growth relative to controls. The mean @entity0 volumes were the following: control, 1090    89 mm(3); 30 mg/kg per day, 612    46 mm(3); 50 mg/kg per day, 563    38 mm(3); and 70 mg/kg per day, 221    26 mm(3). @entity0 volumes reached statistical significance relative to control xenografts (30 mg/kg per day, P < 0.05; 50 mg/kg per day, P < 0.05; 70 mg/kg per day, P < 0.01). Increasing concentrations of @entity11 led to increased DNA fragmentation observed on gel electrophoresis and in the TUNEL assay (control, 1.6%    0.3%; 30 mg/kg per day, 2.9%    0.5%; 50 mg/kg per day, 3.15%    0.7%, and 70 mg/kg per day, 4.86%    0.9%). Western blot analysis revealed increased expression of @entity5 , @entity12 , cleaved- @entity9 and cleaved- @entity3 proteins, which induce apoptosis, but decreased expression of @entity4 protein, which is an inhibitor of apoptosis, following administration of @entity11 . CONCLUSION: @entity11 suppresses growth of BEL7402 @entity2 cells in vivo, in part through apoptosis induction, and is thus a candidate for therapeutic treatment of @entity2 .

title: @entity10 induces apoptosis in XXXX xenografts in @entity1 .

answer: @entity2


abstract: AIM: To evaluate the efficacy of @entity10 ( @entity11 ) as a chemotherapeutic agent for the treatment of @entity2 ( @entity2 ). METHODS: BALB/c @entity1 were randomized into four groups 24 h before subcutaneous injection of hepatocarcinoma BEL7402 cells suspended in @entity8 buffered saline (PBS) into the right flank. The control group (n = 10) was fed a standard diet while treatment groups (n = 10 each) were fed a standard daily diet supplemented with different concentrations of @entity11 (30, 50 and 70 mg/kg per day) for 21 d. @entity0 growth was measured once each week, and @entity0 volume (V) was calculated with the following equation: V = (L * W(2)) * 0.52, where L is the length and W is the width of the xenograft. After 21 d, @entity1 were killed under ether anesthesia, and @entity0 were excised and weighed. Apoptosis was evaluated through detection of DNA fragmentation with gel electrophoresis and the terminal deoxynucleotidyl transferase-mediated @entity7 - @entity6 nick end labeling (TUNEL) assay. Western blot analysis was performed to determine the expression of apoptosis-related proteins @entity5 , @entity4 , @entity12 , cleaved @entity9 , and cleaved @entity3 . RESULTS: @entity11 suppressed @entity0 growth relative to controls. The mean @entity0 volumes were the following: control, 1090    89 mm(3); 30 mg/kg per day, 612    46 mm(3); 50 mg/kg per day, 563    38 mm(3); and 70 mg/kg per day, 221    26 mm(3). @entity0 volumes reached statistical significance relative to control xenografts (30 mg/kg per day, P < 0.05; 50 mg/kg per day, P < 0.05; 70 mg/kg per day, P < 0.01). Increasing concentrations of @entity11 led to increased DNA fragmentation observed on gel electrophoresis and in the TUNEL assay (control, 1.6%    0.3%; 30 mg/kg per day, 2.9%    0.5%; 50 mg/kg per day, 3.15%    0.7%, and 70 mg/kg per day, 4.86%    0.9%). Western blot analysis revealed increased expression of @entity5 , @entity12 , cleaved- @entity9 and cleaved- @entity3 proteins, which induce apoptosis, but decreased expression of @entity4 protein, which is an inhibitor of apoptosis, following administration of @entity11 . CONCLUSION: @entity11 suppresses growth of BEL7402 @entity2 cells in vivo, in part through apoptosis induction, and is thus a candidate for therapeutic treatment of @entity2 .

title: XXXX induces apoptosis in @entity2 xenografts in @entity1 .

answer: @entity10


abstract: AIM: To evaluate the efficacy of @entity10 ( @entity11 ) as a chemotherapeutic agent for the treatment of @entity2 ( @entity2 ). METHODS: BALB/c @entity1 were randomized into four groups 24 h before subcutaneous injection of hepatocarcinoma BEL7402 cells suspended in @entity8 buffered saline (PBS) into the right flank. The control group (n = 10) was fed a standard diet while treatment groups (n = 10 each) were fed a standard daily diet supplemented with different concentrations of @entity11 (30, 50 and 70 mg/kg per day) for 21 d. @entity0 growth was measured once each week, and @entity0 volume (V) was calculated with the following equation: V = (L * W(2)) * 0.52, where L is the length and W is the width of the xenograft. After 21 d, @entity1 were killed under ether anesthesia, and @entity0 were excised and weighed. Apoptosis was evaluated through detection of DNA fragmentation with gel electrophoresis and the terminal deoxynucleotidyl transferase-mediated @entity7 - @entity6 nick end labeling (TUNEL) assay. Western blot analysis was performed to determine the expression of apoptosis-related proteins @entity5 , @entity4 , @entity12 , cleaved @entity9 , and cleaved @entity3 . RESULTS: @entity11 suppressed @entity0 growth relative to controls. The mean @entity0 volumes were the following: control, 1090    89 mm(3); 30 mg/kg per day, 612    46 mm(3); 50 mg/kg per day, 563    38 mm(3); and 70 mg/kg per day, 221    26 mm(3). @entity0 volumes reached statistical significance relative to control xenografts (30 mg/kg per day, P < 0.05; 50 mg/kg per day, P < 0.05; 70 mg/kg per day, P < 0.01). Increasing concentrations of @entity11 led to increased DNA fragmentation observed on gel electrophoresis and in the TUNEL assay (control, 1.6%    0.3%; 30 mg/kg per day, 2.9%    0.5%; 50 mg/kg per day, 3.15%    0.7%, and 70 mg/kg per day, 4.86%    0.9%). Western blot analysis revealed increased expression of @entity5 , @entity12 , cleaved- @entity9 and cleaved- @entity3 proteins, which induce apoptosis, but decreased expression of @entity4 protein, which is an inhibitor of apoptosis, following administration of @entity11 . CONCLUSION: @entity11 suppresses growth of BEL7402 @entity2 cells in vivo, in part through apoptosis induction, and is thus a candidate for therapeutic treatment of @entity2 .

title: @entity10 induces apoptosis in @entity2 xenografts in XXXX .

answer: @entity1


abstract: AIM: To investigate the clinical usefulness of early endoscopic ultrasonography (EUS) in the management of @entity4 ( @entity4 ). METHODS: All consecutive @entity0 entering the emergency department between January 2010 and December 2012 due to acute @entity2 and showing biochemical and/or radiological findings consistent with possible @entity4 were prospectively enrolled. @entity0 were classi   ed as having a low, moderate, or high probability of common bile duct (CBD) stones, according to the established risk strati   cation. Exclusion criteria were: gastrectomy or @entity0 in whom the cause of @entity1 was already identified by ultrasonography. All enrolled @entity0 underwent EUS within 48 h of their admission. Endoscopic retrograde cholangiopancreatography was performed immediately after EUS only in those cases with proven CBD stones or sludge. The following parameters were investigated: (1) clinical: age, sex, fever; (2) radiological: dilated CBD; and (3) biochemical: @entity3 , @entity7 , ALT, gGT, @entity6 , amylase, lipasis, PCR. Association between presence of CBD stone at EUS and the individual predictors were assessed by univariate logistic regression. Predictors significantly associated with CBD stones (P < 0.05) were entered in a multivariate logistic regression model. RESULTS: A total of 181 @entity0 with @entity5 were admitted to the emergency department between January 2010 and December 2012. After exclusion criteria a total of 71 @entity0 (38 females, 53.5%, mean age 58    20.12 years, range 27-89 years; 33 males, 46.5%, mean age 65    11.86 years, range 41-91 years) were included in the present study. The probability of CBD stones was considered low in 21 cases (29%), moderate in 26 (37%), and high in the remaining 24 (34%). The 71 @entity0 included in the study underwent EUS, which allowed for a complete evaluation of the target sites in all the cases. The procedure was completed in a mean time of 14.7 min (range 9-34 min), without any notable complications.The overall CBD stone frequency was 44% (31 of 71), with a significant increase from the group at low pretest probability to that at moderate (OR = 5.79, P = 0.01) and high (OR = 4.25, P = 0.03) pretest probability. CONCLUSION: Early EUS in @entity4 allows, if appropriate, immediate endoscopic treatment and significant spare of unnecessary operative procedures thus reducing possible related complications.

title: Early endoscopic ultrasonography in XXXX : A prospective pilot study.

answer: @entity4


abstract: An intrinsic defect in the aortic media in six @entity0 with @entity5 , who died of @entity1 at an average age of 32 years, has been delineated by correlated morphologic, biochemical, and mechanical studies. The findings in the Marfan aortas have been compared with those in age- and sex-matched controls, who died of unrelated diseases without significant @entity6 , and in three @entity0 with dissecting @entity3 of non-Marfan origin. The results showed that there was a significant reduction in the tensile strength of the aorta in @entity5 . This finding was correlated by scanning electron microscopy with structural alterations of the medial elastic fibers, including enlarged interlaminar spaces and loss of interlaminar elastic fibrils. No structural alterations were identified in collagen fibers. Biochemical analyses of the aortic media revealed a substantial reduction in aortic @entity7 content. Furthermore, the @entity8 content of the isolated @entity7 was reduced by approximately 50%. No changes were detected in the composition or solubility of the medial collagen. In contrast to Marfan aortas, the @entity7 and collagen contents of the dissecting @entity3 of non-Marfan origin were similar to those of the controls. These findings suggest that the @entity4 in @entity5 may be based on a @entity2 affecting @entity7 fibrillogenesis.

title: XXXX : structural, biochemical, and mechanical studies of the aortic media.

answer: @entity5


abstract: @entity0 with @entity6 ( @entity6 ) frequently have @entity3 and @entity5 . We prospectively examined the upper and lower gastrointestinal tracts in 22 @entity6 @entity0 , although severe medical problems often precluded full evaluation. Ninety-six percent (21 of 22) lost weight, and 55% (12 of 22) had @entity3 . The mean (+/- SD) @entity5 was 34 +/- 19 lb. @entity12 was found in 4 of 14 @entity0 , and @entity11 tests were abnormal in 8 of 14 patients. Mean serum albumin was 3.3 +/- 0.8 g/dl. A significantly diminished plasma @entity10 level, which can influence immune function, was noted in these @entity6 @entity0 . @entity4 were identified in 45% of @entity0 . Although @entity14 were more common in the infected group, @entity5 and albumin were similar in those with and without demonstrated @entity2 . Flexible sigmoidoscopy showed that of 15 @entity0 , there were two with @entity8 , 10 normals, and three with nonspecific @entity7 . Infection was documented in all @entity0 with @entity7 . Panendoscopy of the upper gastrointestinal tract was positive for @entity6 -related pathology in five of 10 @entity0 , including two with @entity8 , one with @entity9 , one with @entity9 , and one with @entity13 (biopsy positive for cryptosporidia); five @entity0 had a normal-appearing tract. Small bowel or colonic biopsies frequently showed nonspecific inflammatory changes, although pathogens were identified in six @entity0 (27% of all biopsies). We conclude that a wide variety of @entity4 , which includes @entity1 , and inflammatory changes, may occur in @entity6 @entity0 . Therefore, @entity6 @entity0 , particularly those with @entity3 or @entity5 , deserve an intensive evaluation for remediable lesions of their gastrointestinal tracts.

title: Gastrointestinal manifestations of the XXXX : a review of 22 cases.

answer: @entity6