abstract: BACKGROUND: @entity4 is a chronic @entity1 of unknown etiology commonly seen among orientals and characterized histologically by lymphatic follicles, vascular proliferation, and marked @entity3 . It has a predilection for the head and neck region. The lesion is benign but can be mistaken to be a malignant lesion. METHODS: Between January 1987 and December 1999, eight cases of @entity4 were treated at the Department of Plastic Surgery, Hospital Kuala Lumpur. All the @entity0 underwent surgical excision followed by initial high-dose @entity2 therapy and low-dose maintenance. RESULTS: All the @entity0 are @entity0 , seven belong to the Malay race and one is Chinese. The @entity0 ' ages at diagnosis are 18 to 46 years. All were initially seen with swelling in the parotid gland, ranging from 1 year to 20 years' duration. Pruritus of the overlying skin was seen in seven @entity0 . Treatment by surgical excision and @entity2 therapy has led to no recurrences. CONCLUSION: @entity4 of parotid gland is rare. It is a chronic inflammatory condition also called @entity4 . Treatment by surgical excision and @entity2 therapy has led to no recurrences.

title: XXXX of parotid gland presenting as solitary parotid swelling.

answer: @entity4


abstract: In 1979-1981, 107 @entity0 with @entity1 were treated with Psorilux 9050 emitting 1.24 mW/cm2 at 280-315 nm and 7.33 mW/cm2 at 315-400 nm. Half of the @entity0 received one treatment course, 20% 2-3 courses, and one third more than 3 treatment courses. A good result was obtained in 93% of the cases but in the other cases the treatment was either ineffective or the @entity0 were too sensitive to the radiation. After the treatment, the need for treatment with topical corticosteroids had decreased in one half of the @entity0 and increased in only 2% of them. In 1982-1983, 89 atopics were treated with Metec Helarium model 1480, emitting both UVB and UVA (310-340 nm, with a peak at 320-330 nm). One treatment course, 3-45 weeks (mean 19 weeks), was given to 69 @entity0 , and two treatment courses to 20 @entity0 . The treatment was effective in 94% of the @entity0 . The others did not respond. After the treatment, the need of treatment with topical corticosteroids had decreased in 85% of the cases, and increased in none. Psorilux therapy caused II degree burns in two @entity0 and erythema lasting greater than 24 hours in 11 @entity0 . Erythema was encountered in 14 @entity0 receiving Metec Helarium therapy but in no cases II degree burns. Seventeen @entity0 received both Psorilux and Metec Helarium therapies and 14 of them preferred the latter.

title: Ultraviolet light therapy in XXXX .

answer: @entity1


abstract: The effects of physical restraint and poly I:C treatment on the growth of MOPC 104E @entity3 and @entity1 @entity2 and survival of animals bearing such @entity0 were investigated. Our studies show that in the Balb/c @entity1 with MOPC 104E @entity3 the effects of restraint stress were detrimental and lead to early death of the @entity1 . When the restraint was combined with poly I:C, during the early course of the disease, restraint stress neutralized the beneficial effects of the poly I:C treatment. These studies show that under certain circumstances, restraint stress can negate the effects of therapy. On the other hand, restraint stress produced an opposite effect in C3H/He @entity1 with @entity1 @entity2 treated in the same fashion. In @entity1 with @entity2 , restraint stress delayed @entity0 growth and increased the median survival time. When restraint stress was combined with poly I:C treatment, the mean @entity0 size was smaller and median survival was substantially increased over the control group. Because poly I:C therapy delayed @entity0 growth and increased survival in both models, efforts to strengthen this response were tested by conditioning. Our studies show the response to poly I:C as measured by elevation of the NK activity could be conditioned with @entity4 smell. Conditioning of the host to raise immune activity to alter the outcome of disease is a new area yet to be explored and has important clinical significance. These studies, we believe, are important because they explore the connection between mind and body and resistance to disease.

title: Neural and environmental influences on XXXX and conditioning of NK activity.

answer: @entity0


abstract: 23 @entity1 @entity0 were treated with the new fixed-dose combination drug Beta-Aldopur, containing 100 mg @entity7 and 50 mg @entity5 per tablet. In part they had been pretreated with other fixed combinations without sufficient success. 19 @entity0 completed the eight-week study. Initial dosage of two tablets could be reduced to one tablet daily following normalization (less than 90 mm Hg) of diastolic blood pressure in one third of @entity0 . Mean pressure in a sitting posture was lowered from 176 +/- 21/111 +/- 9 mm Hg to 156 +/- 21/93 +/- 8 mm Hg (p less than 0,0001) gradually until the 4th week. Body weight decreased by 2.5 kg (3.1%) until the 6th week and remained constant thereafter. Mean concentration of serum @entity2 rose significantly by 0.42 mmol/l within normal limits. Specific and non-specific side effects were very rare and no serious reactions occurred. Compared to pretreatment with other fixed combinations, most of them containing @entity6 , the combination of @entity7 with @entity5 was more efficacious in lowering the blood pressure. According to the results of our study Beta-Aldopur is suitable for treatment of essential @entity1 of all degrees, especially for @entity0 prone to @entity4 , if secondary @entity3 caused by @entity1 or by medication may be expected and/or if other medications are not adequately effective.

title: [Treatment of medium-severe essential XXXX with beta-Aldopur under practice conditions].

answer: @entity1


abstract: @entity3 are among the most frequently encountered health problems in @entity0 of family physicians. The diagnosis requires the demonstration of more than 100,000 bacterial colonies per milliliter in a freshly voided urine specimen. @entity7 , @entity4 , and @entity8 are unreliable diagnostic criteria. The pathogenesis is uncertain although vaginal colonization with enteric bacteria, voluntary avoidance of urination, and sexual intercourse are contributing causes. @entity6 is related to recurrent infection but a causal relationship has not been established. @entity3 in @entity0 is related to @entity1 , but therapy of the infections does not prevent @entity1 . @entity2 disappear spontaneously in up to 40 percent of adult @entity0 . Bacteriuria in pregnancy, however, is related to low birth weight in @entity0 and increased perinatal mortality. Asymptomatic @entity5 need not be diagnosed or treated except in pregnant @entity0 . For symptomatic infections, short-term antibiotic therapy is as effective as long-term therapy. Prophylactic antibiotics and therapy by modification of behavior using a multifaceted regimen can reduce the frequency of recurrent infection.

title: The spectrum of XXXX in family practice.

answer: @entity3


abstract: A broad spectrum of immunologic parameters was investigated in 13 cases of @entity8 ( @entity8 ), including those for cellular immunity which has attracted little attention in the past. One was a 46-year-old @entity0 having both @entity8 and a @entity4 . This association between @entity8 and @entity4 is probably coincidental without biologic significance. There was no evidence of @entity1 in the remaining 12 @entity0 . The delayed cutaneous @entity2 to @entity7 was anergic in 3 @entity0 and showed impaired positive reactivity in 3 @entity0 , as compared with no failure of response in normal adults or @entity0 with @entity6 . A high proportion of @entity0 with @entity8 displayed positive tuberculin reactions, as did controls. Our case of @entity8 with a @entity4 showed marked @entity5 , but the number of lymphocytes in peripheral blood in the remaining 12 @entity0 was normal. Uptake of @entity3 by lymphocytes in the presence of phytohemagglutinin was normal. Serum gammaglobulin was reduced in 4 @entity0 with @entity8 . The mean value of serum immunoglobulin level was decreased only in the class of IgG. A wider derangement of immunologic function may occur in @entity8 than was previously recognized.

title: Immunologic derangement in @entity8 --abnormal contact sensitization to XXXX .

answer: @entity7


abstract: A broad spectrum of immunologic parameters was investigated in 13 cases of @entity8 ( @entity8 ), including those for cellular immunity which has attracted little attention in the past. One was a 46-year-old @entity0 having both @entity8 and a @entity4 . This association between @entity8 and @entity4 is probably coincidental without biologic significance. There was no evidence of @entity1 in the remaining 12 @entity0 . The delayed cutaneous @entity2 to @entity7 was anergic in 3 @entity0 and showed impaired positive reactivity in 3 @entity0 , as compared with no failure of response in normal adults or @entity0 with @entity6 . A high proportion of @entity0 with @entity8 displayed positive tuberculin reactions, as did controls. Our case of @entity8 with a @entity4 showed marked @entity5 , but the number of lymphocytes in peripheral blood in the remaining 12 @entity0 was normal. Uptake of @entity3 by lymphocytes in the presence of phytohemagglutinin was normal. Serum gammaglobulin was reduced in 4 @entity0 with @entity8 . The mean value of serum immunoglobulin level was decreased only in the class of IgG. A wider derangement of immunologic function may occur in @entity8 than was previously recognized.

title: Immunologic derangement in XXXX --abnormal contact sensitization to @entity7 .

answer: @entity8


abstract: The extent of the binocular cortical field in albino @entity0 , as revealed by recording from single cells, was almost normal; although the input from the ipsilateral eye was weaker than normal, most cells were driven from both eyes. By backfilling retinal @entity3 cells from one optic tract with horseradish peroxidase we examined the origins of the retinofugal projections. Filled cells ipsilateral to the injected tract were concentrated in a crescent-shaped area bordering the inferior temperal retina. In black @entity0 this area constituted 20% of the total retinal area, in albinos 17%. In black @entity0 we counted nearly 1,000 labeled cells in the @entity1 , or 2.6% of all cells filled in both eyes. Albinos had about one-third fewer filled cells ipsilaterally than black @entity0 . Four percent of all ipsilaterally filled cells in black @entity0 and 8% in albinos were scattered outside of the crescent region. The density of ipsilaterally projecting cells was uniform throughout the crescent region in black @entity0 , but decreased toward the central retina in albinos. In retinas contralateral to the injection up to 39,000 cells were filled-about two-thirds of the cells in the @entity3 -cell layer whose cytoplasm contained conspicuous Nissl substance. Depending on classification of unfilled cells as @entity3 cells or interneurons, we estimated a @entity2 cells to exist in the retina. The size distribution of ipsilaterally projecting @entity3 cells was similar in albinos and normals. Ipsilaterally projecting @entity3 cells were on average 1.8-3 times larger in volume than contralaterally projecting ones in both types of @entity0 . @entity3 cells were relatively more common in ipsilateral retinofugal projections: 21% of all @entity3 cells were displaced versus less than 1% of all the @entity3 cells in black @entity0 . In albinos only 13% of the @entity3 cells in the @entity1 were displaced. The overall reduction in ipsilaterally projecting cells in albinos was reflected twice as much in displaced @entity3 cells as in normally placed ones.

title: Origins of crossed and uncrossed retinal projections in pigmented and albino XXXX .

answer: @entity0


abstract: The present investigation deals with the functional recovery of the @entity0 incisor periodontium following application of optimal intrusive loads for a period of 2 weeks and addresses the relationship between function and integrity of dental and periodontal tissues. The daily rate of @entity3 served as an indicator of the functional capacity of the @entity0 periodontal ligament (PDL), while the condition of the PDL was evaluated by means of serial histologic sections. The left mandibular incisors of thirteen experimental and seven control @entity0 were shortened to prevent occlusion, and calibrated loads of 19 +/- 1.6 grams were applied to the teeth of the experimental animals. Following removal of the springs, the daily rate of @entity3 of all teeth was measured during a recovery period of 80 days. In all experimental animals, prolonged impairment of the eruptive potential had occurred: In 50% the rate of @entity3 was fully restored 8 weeks after removal of the loads, and in these animals the histologic evaluation showed an almost normal PDL. In the remaining 50% gross impediment in the @entity3 rate persisted throughout the entire experimental period. The intratissue forces operating during the recovery period had sufficient strength to cause a degree of periodontal injury equivalent to that ensuant on direct loading. Extensive newly developed @entity1 were evident in the initially stretched mesial PDL. Areas of dentin resorption, denuded cementum, and injured enamel appeared a considerable time after load removal. Periodontal @entity2 and loss of attachment of collagen fibers, presence of scarlike tissue, and infiltration of inflammatory cells.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Recovery of the dental and periodontal tissues of the XXXX incisor following application of continuous intrusive loads: a long-term study.

answer: @entity0


abstract: @entity8 is a common @entity3 consisting of multiple tics and vocal noises. We summarize here clinical aspects of 250 consecutive cases seen over a period of 3 years. The sex ratio was four males to one female, and the mean age of onset was 6.9 years. Only 10% were Jewish, indicating that it is not more prevalent in Ashkenazi Jews. Only 33% had compulsive swearing (coprolalia), indicating that this is not necessary for the diagnosis. The most frequent initial symptoms were rapid eye-blinking, facial grimacing, and throat-clearing. In this series, it was clear that @entity8 is a @entity4 as well as a @entity1 . Significant discipline problems and/or problems with anger and violence occurred in 61%, and 54% had @entity2 with @entity5 . Some degree of exhibitionism was present in 15.9% of males and 6.1% of females. @entity6 was seen in 32%. Other than tics and vocal noises, the most common parental complaints were of short temper and everything being a confrontation. There were no significant clinical differences between familial and sporadic cases. Whenever a @entity0 presents with a @entity7 , @entity2 , or significant discipline or emotional problems, the parents should be questioned about the presence of tics or vocal noises in the @entity0 and other family members.

title: XXXX : clinical and psychological aspects of 250 cases.

answer: @entity8


abstract: Compounds with primary @entity0 groups react with @entity7 in solution to yield highly fluorescent products. This reaction is now in wide use for detecting @entity1 and @entity5 in liquid-chromatography effluents. We report here a method for using @entity7 to detect @entity2 in the effluent of a gas-liquid-chromatographic column. The effluent gas, nominally 20 mL/min, is delivered to a scrubber consisting of a small-bore, simulated capillary chromatographic column that is simultaneously supplied with 1 mL/min of the reagent solution. The liquid effluent of the scrubber, separated from the gas, is drawn through the flow cell of a fluorometer. Short-chain @entity5 and @entity3 were quantitatively scrubbed. The response of the fluorometer was directly proportional to the number of nanomoles injected into the column. Less than a nanomole of @entity6 was detectable. Comparison of results with those from a @entity4 flame-ionization detector showed minimal additional peak broadening or compromise of resolution. These results demonstrate the feasibility of using highly specific, as well as sensitive, liquid-chromatographic detection methods for gas-liquid chromatography.

title: Specific detection of XXXX in the effluent of a gas-chromatographic column by on-line measurement of fluorescence.

answer: @entity2


abstract: The decay rates of several messenger RNA species were determined in @entity0 @entity3 cells. The t1/2 values for the actin and tubulin mRNAs were 16 to 26 hours and about seven hours, respectively. The globin mRNA, and two mRNA species subject to translation repression, the @entity4 and @entity2 mRNAs, were about as stable as the ribosomal RNA. A stable tubulin mRNA component also appeared to be present in the cells. Exposure of the cells to @entity1 for 48 hours led to considerable increases in the rates of decay of all but the globin mRNA. The induction of erythroid differentiation caused by the drug appears to lead to activation of a mRNA-degradation process that affects individual species to different degrees. The newly synthesized actin and tubulin mRNAs lost their poly(A) rather rapidly. This was accompanied by accumulation of poly(A)-deficient mRNA chains, particularly in the case of actin mRNA. The steady-state distribution of mRNA components, determined by Northern blot analysis, also showed that the actin mRNA and one tubulin mRNA species have a high proportion of poly(A)-deficient molecules. The globin, @entity4 and @entity2 mRNAs showed little tendency to lose their poly(A) sequence. The steady-state globin and @entity4 mRNAs also had a low proportion of chains depleted of poly(A). For all five species, the proportions of poly(A)-deficient chains in newly synthesized mRNA were about the same in uninduced and induced cells, in spite of the large decreases in mRNA stability in the induced cells. The lack of correlation between tendency to lose poly(A) and rate of mRNA decay, and the large accumulation of poly(A)-deficient molecules in the cases of the actin and tubulin mRNAs suggest that the stability of mRNA is not determined solely by the presence of poly(A) on the RNA chains. The behavior of the untranslated species in induced and uninduced cells also fails to support the notion of a relationship between translation and mRNA decay.

title: Regulation of messenger RNA stability in @entity0 XXXX cells.

answer: @entity3


abstract: The decay rates of several messenger RNA species were determined in @entity0 @entity3 cells. The t1/2 values for the actin and tubulin mRNAs were 16 to 26 hours and about seven hours, respectively. The globin mRNA, and two mRNA species subject to translation repression, the @entity4 and @entity2 mRNAs, were about as stable as the ribosomal RNA. A stable tubulin mRNA component also appeared to be present in the cells. Exposure of the cells to @entity1 for 48 hours led to considerable increases in the rates of decay of all but the globin mRNA. The induction of erythroid differentiation caused by the drug appears to lead to activation of a mRNA-degradation process that affects individual species to different degrees. The newly synthesized actin and tubulin mRNAs lost their poly(A) rather rapidly. This was accompanied by accumulation of poly(A)-deficient mRNA chains, particularly in the case of actin mRNA. The steady-state distribution of mRNA components, determined by Northern blot analysis, also showed that the actin mRNA and one tubulin mRNA species have a high proportion of poly(A)-deficient molecules. The globin, @entity4 and @entity2 mRNAs showed little tendency to lose their poly(A) sequence. The steady-state globin and @entity4 mRNAs also had a low proportion of chains depleted of poly(A). For all five species, the proportions of poly(A)-deficient chains in newly synthesized mRNA were about the same in uninduced and induced cells, in spite of the large decreases in mRNA stability in the induced cells. The lack of correlation between tendency to lose poly(A) and rate of mRNA decay, and the large accumulation of poly(A)-deficient molecules in the cases of the actin and tubulin mRNAs suggest that the stability of mRNA is not determined solely by the presence of poly(A) on the RNA chains. The behavior of the untranslated species in induced and uninduced cells also fails to support the notion of a relationship between translation and mRNA decay.

title: Regulation of messenger RNA stability in XXXX @entity3 cells.

answer: @entity0


abstract: In @entity15 ( @entity15 -46 @entity0 ) and various entities of chronic @entity3 ( @entity17 -58 @entity0 ) an evaluation and comparison of clinical and postmortem findings has been performed. This study included also aspirates and core biopsies of the bone marrow which were initially taken on admission of those @entity0 . Classification of @entity17 was done following the concept of Georgii et al. (1984) into CGL -24-, CMGM-6-, E- @entity1 -13- and @entity1 /OMS-15 cases. There was a significant increase in blastic crisis in CGL compared with the other entities and in the latter a prolongation of the total course of disease due to a long period between symptoms--clinical diagnosis. As revealed by the autopsies causes of @entity5 were @entity6 ( @entity2 , @entity7 -50%) and lethal @entity9 (gastrointestinal and cerebral--about 30%) in both @entity15 and CMGM @entity0 . Rare causes comprised fatal @entity12 due to a peripheral @entity11 in @entity17 , @entity14 of the myocard in @entity15 . In addition to the well known giant enlargement of the spleen in @entity1 /OMS, the relatively high frequency of a @entity10 (meningeosis leukemica) in @entity15 (about 35%) and during an acute transformation in @entity17 (up to 30%) was conspicuous. The examination of the bone marrow at various sites became feasible during the postmortem procedure and thus provided the opportunity to investigate the development and extent of a @entity16 evolving in @entity17 . In contrast to the a- or @entity8 and regeneration of the @entity13 following chemotherapy, the evolution of @entity4 showed a very uniform pattern throughout the skeleton and obviously no reversal of a manifest @entity1 /OMS after cytotoxic treatment.

title: Autopsy and clinical findings in @entity15 and chronic XXXX --an evaluation of 104 @entity0 .

answer: @entity3


abstract: In @entity15 ( @entity15 -46 @entity0 ) and various entities of chronic @entity3 ( @entity17 -58 @entity0 ) an evaluation and comparison of clinical and postmortem findings has been performed. This study included also aspirates and core biopsies of the bone marrow which were initially taken on admission of those @entity0 . Classification of @entity17 was done following the concept of Georgii et al. (1984) into CGL -24-, CMGM-6-, E- @entity1 -13- and @entity1 /OMS-15 cases. There was a significant increase in blastic crisis in CGL compared with the other entities and in the latter a prolongation of the total course of disease due to a long period between symptoms--clinical diagnosis. As revealed by the autopsies causes of @entity5 were @entity6 ( @entity2 , @entity7 -50%) and lethal @entity9 (gastrointestinal and cerebral--about 30%) in both @entity15 and CMGM @entity0 . Rare causes comprised fatal @entity12 due to a peripheral @entity11 in @entity17 , @entity14 of the myocard in @entity15 . In addition to the well known giant enlargement of the spleen in @entity1 /OMS, the relatively high frequency of a @entity10 (meningeosis leukemica) in @entity15 (about 35%) and during an acute transformation in @entity17 (up to 30%) was conspicuous. The examination of the bone marrow at various sites became feasible during the postmortem procedure and thus provided the opportunity to investigate the development and extent of a @entity16 evolving in @entity17 . In contrast to the a- or @entity8 and regeneration of the @entity13 following chemotherapy, the evolution of @entity4 showed a very uniform pattern throughout the skeleton and obviously no reversal of a manifest @entity1 /OMS after cytotoxic treatment.

title: Autopsy and clinical findings in XXXX and chronic @entity3 --an evaluation of 104 @entity0 .

answer: @entity15


abstract: In @entity15 ( @entity15 -46 @entity0 ) and various entities of chronic @entity3 ( @entity17 -58 @entity0 ) an evaluation and comparison of clinical and postmortem findings has been performed. This study included also aspirates and core biopsies of the bone marrow which were initially taken on admission of those @entity0 . Classification of @entity17 was done following the concept of Georgii et al. (1984) into CGL -24-, CMGM-6-, E- @entity1 -13- and @entity1 /OMS-15 cases. There was a significant increase in blastic crisis in CGL compared with the other entities and in the latter a prolongation of the total course of disease due to a long period between symptoms--clinical diagnosis. As revealed by the autopsies causes of @entity5 were @entity6 ( @entity2 , @entity7 -50%) and lethal @entity9 (gastrointestinal and cerebral--about 30%) in both @entity15 and CMGM @entity0 . Rare causes comprised fatal @entity12 due to a peripheral @entity11 in @entity17 , @entity14 of the myocard in @entity15 . In addition to the well known giant enlargement of the spleen in @entity1 /OMS, the relatively high frequency of a @entity10 (meningeosis leukemica) in @entity15 (about 35%) and during an acute transformation in @entity17 (up to 30%) was conspicuous. The examination of the bone marrow at various sites became feasible during the postmortem procedure and thus provided the opportunity to investigate the development and extent of a @entity16 evolving in @entity17 . In contrast to the a- or @entity8 and regeneration of the @entity13 following chemotherapy, the evolution of @entity4 showed a very uniform pattern throughout the skeleton and obviously no reversal of a manifest @entity1 /OMS after cytotoxic treatment.

title: Autopsy and clinical findings in @entity15 and chronic @entity3 --an evaluation of 104 XXXX .

answer: @entity0


abstract: OBJECTIVES: To describe the prevalence of hysterectomy for @entity0 aged 18-45 seeking treatment at a @entity2 clinic, to describe @entity0 characteristics ( @entity1 intensity, age, smoking status, hormone replacement status, and psychosocial factors) based on opioid and hysterectomy status, and to determine whether hysterectomy status predicted receipt of opioid prescription. DESIGN: Retrospective cross-sectional chart review. @entity0 : Total 323 new female @entity0 aged 18-45 who completed the Brief @entity1 Inventory-Short Form at initial evaluation at a @entity2 clinic during a 12-month period (July 2008-June 2009). MEASURES: Data were collected from the Brief @entity1 Inventory and medical charts. Variables included opioid prescription, average @entity1 intensity, @entity1 type, age, hysterectomy status, smoking status, and @entity1 across domains measured by the Brief @entity1 Inventory. The association of opioid prescription with hysterectomy and other factors were determined by logistic regression. RESULTS: Prevalence of hysterectomy was 28.8%. Average @entity1 intensity was not associated with either hysterectomy or opioid prescription status. However, hysterectomy and high levels of @entity1 were significantly and independently associated with opioid prescription after adjusting for age and @entity1 intensity. More than 85% of @entity0 with hysterectomy and high @entity1 had opioid prescription. CONCLUSIONS: Hysterectomy may confer risk for @entity1 and opioid prescription in @entity0 45 and younger. More research is needed to understand 1) how @entity0 characteristics influence prescribing patterns and 2) the specific medical risks and consequences of chronic opioid therapy in this population.

title: Hysterectomy and predictors for opioid prescription in a XXXX clinic sample.

answer: @entity2


abstract: BACKGROUND: The promotion of physical activity among an overweight/ @entity1 population is an important challenge for clinical practitioners and researchers. In this regard, completing a questionnaire on cognitions could be a simple and easy strategy to increase levels of physical activity. Thus, the aim of the present study was to test the effect of completing a questionnaire based on the Theory of Planned Behavior (TPB) on the level of physical activity. METHODS: Overall, 452 overweight/ @entity1 adults were recruited and randomized to the experimental or control group. At baseline, @entity0 completed a questionnaire on cognitions regarding their participation in leisure-time physical activity (experimental condition) versus a questionnaire on fruit and vegetable consumption (control condition). The questionnaires assessed the TPB variables that are beliefs, attitude, norm, perception of control, intention and a few additional variables from other theories. At three-month follow-up, leisure-time physical activity was self-reported by means of a short questionnaire. An analysis of covariance with baseline physical activity level as covariate was used to verify the effect of the intervention. RESULTS: At follow-up, 373 @entity0 completed the leisure-time physical activity questionnaire. The statistical analysis showed that physical activity participation was greater among @entity0 in the experimental condition than those in the control condition (F(1,370)=6.85, p=.009, d=0.20). CONCLUSIONS: Findings indicate that completing a TPB questionnaire has a significant positive impact on subsequent participation in physical activity. Consequently, asking individuals to complete such a questionnaire is a simple, inexpensive and easy strategy to increase the level of physical activity among overweight/ @entity1 adults.

title: The effect of mere-measurement of cognitions on physical activity behavior: a randomized controlled trial among overweight and XXXX individuals.

answer: @entity1


abstract: OBJECTIVE: Performance of middle-ear surgery under local anaesthesia has several advantages, but many @entity0 complain of @entity2 , @entity1 and adverse events (e.g. dizziness and @entity3 ). To minimise such problems, we compared sedation with @entity4 alone versus @entity4 with @entity5 . @entity0 AND METHODS: We initially observed 19 @entity0 undergoing middle-ear surgery under local anaesthesia, as controls. We then sedated a further 40 @entity0 undergoing such surgery, with either @entity4 or @entity4 plus @entity5 . RESULTS: The sedated @entity0 had significantly lower incidences of local anaesthesia injection @entity2 (p < 0.001), intra-operative @entity2 (p < 0.001), intra-operative @entity1 (p < 0.001) and adverse events, compared with the control group. @entity0 sedated with @entity4 plus @entity5 reported less intra-operative @entity1 (p = 0.010) and greater post-operative satisfaction with sedation (p = 0.007), compared with those sedated with @entity4 only. CONCLUSION: @entity0 undergoing middle-ear surgery under local anaesthesia alone frequently report @entity2 , @entity1 and adverse events. However, the majority of our @entity0 who were sedated with @entity4 satisfactorily overcame @entity2 , @entity1 and adverse events. Results were better still when @entity4 was accompanied by @entity5 .

title: Middle-ear surgery under sedation: comparison of @entity4 alone or @entity4 with XXXX .

answer: @entity5


abstract: OBJECTIVE: Performance of middle-ear surgery under local anaesthesia has several advantages, but many @entity0 complain of @entity2 , @entity1 and adverse events (e.g. dizziness and @entity3 ). To minimise such problems, we compared sedation with @entity4 alone versus @entity4 with @entity5 . @entity0 AND METHODS: We initially observed 19 @entity0 undergoing middle-ear surgery under local anaesthesia, as controls. We then sedated a further 40 @entity0 undergoing such surgery, with either @entity4 or @entity4 plus @entity5 . RESULTS: The sedated @entity0 had significantly lower incidences of local anaesthesia injection @entity2 (p < 0.001), intra-operative @entity2 (p < 0.001), intra-operative @entity1 (p < 0.001) and adverse events, compared with the control group. @entity0 sedated with @entity4 plus @entity5 reported less intra-operative @entity1 (p = 0.010) and greater post-operative satisfaction with sedation (p = 0.007), compared with those sedated with @entity4 only. CONCLUSION: @entity0 undergoing middle-ear surgery under local anaesthesia alone frequently report @entity2 , @entity1 and adverse events. However, the majority of our @entity0 who were sedated with @entity4 satisfactorily overcame @entity2 , @entity1 and adverse events. Results were better still when @entity4 was accompanied by @entity5 .

title: Middle-ear surgery under sedation: comparison of XXXX alone or @entity4 with @entity5 .

answer: @entity4


abstract: OBJECTIVE: Performance of middle-ear surgery under local anaesthesia has several advantages, but many @entity0 complain of @entity2 , @entity1 and adverse events (e.g. dizziness and @entity3 ). To minimise such problems, we compared sedation with @entity4 alone versus @entity4 with @entity5 . @entity0 AND METHODS: We initially observed 19 @entity0 undergoing middle-ear surgery under local anaesthesia, as controls. We then sedated a further 40 @entity0 undergoing such surgery, with either @entity4 or @entity4 plus @entity5 . RESULTS: The sedated @entity0 had significantly lower incidences of local anaesthesia injection @entity2 (p < 0.001), intra-operative @entity2 (p < 0.001), intra-operative @entity1 (p < 0.001) and adverse events, compared with the control group. @entity0 sedated with @entity4 plus @entity5 reported less intra-operative @entity1 (p = 0.010) and greater post-operative satisfaction with sedation (p = 0.007), compared with those sedated with @entity4 only. CONCLUSION: @entity0 undergoing middle-ear surgery under local anaesthesia alone frequently report @entity2 , @entity1 and adverse events. However, the majority of our @entity0 who were sedated with @entity4 satisfactorily overcame @entity2 , @entity1 and adverse events. Results were better still when @entity4 was accompanied by @entity5 .

title: Middle-ear surgery under sedation: comparison of @entity4 alone or XXXX with @entity5 .

answer: @entity4


abstract: OBJECTIVE: To explore the value of @entity3 - @entity1 chemosensitivity assay ( @entity3 - @entity4 ) in individualized treatment of recurrent @entity2 (REOC), and to evaluate the correlation between the in vitro chemosensitivity assay and clinical drug sensitivity. METHODS: Sixty-nine REOC specimens were tested by @entity3 - @entity4 assay retrospectively. The @entity0 were divided into strong sensitive, moderate sensitively and resistant groups according to the @entity3 - @entity4 assay results. The clinical results were evaluated according to imaging and serum @entity5 analysis. The correlation between in vitro @entity3 - @entity4 assay and clinical outcome was statistically analyzed by   (2) test. The progression free survival (PFS) and overall survival (OS) of each group were analyzed using Kaplan-Meier method. RESULTS: The results of @entity3 - @entity4 assay had significant correlation with clinical outcome. The clinical chemotherapy outcome became better with increased drug sensitivity in vitro (  (2) = 9.066, P = 0.004). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate for @entity3 - @entity4 method to predict the clinical chemotherapy sensitivity of REOC were 87.5%, 45.9%, 58.3%, 80.9% and 65.2%, respectively. The mean PFS of strong sensitive group, moderately sensitive group and resistant group were 187.1 days, 195.0 days and 60.3 days, respectively. The mean OS were 476.7, 335.7 and 237.5 days, respectively, following the start of @entity4 -directed therapy. The PFS and OS of the two sensitivity groups in vitro were significantly longer than that of the in vitro-resistant group (P < 0.01). CONCLUSION: The results of @entity3 - @entity4 assay are well correlated with clinical treatment responses. The assay may be an important and useful method for individualized chemotherapy for recurrent @entity2 .

title: [Application of XXXX - @entity1 chemosensitivity assay in recurrent @entity2 ].

answer: @entity3


abstract: OBJECTIVE: To explore the value of @entity3 - @entity1 chemosensitivity assay ( @entity3 - @entity4 ) in individualized treatment of recurrent @entity2 (REOC), and to evaluate the correlation between the in vitro chemosensitivity assay and clinical drug sensitivity. METHODS: Sixty-nine REOC specimens were tested by @entity3 - @entity4 assay retrospectively. The @entity0 were divided into strong sensitive, moderate sensitively and resistant groups according to the @entity3 - @entity4 assay results. The clinical results were evaluated according to imaging and serum @entity5 analysis. The correlation between in vitro @entity3 - @entity4 assay and clinical outcome was statistically analyzed by   (2) test. The progression free survival (PFS) and overall survival (OS) of each group were analyzed using Kaplan-Meier method. RESULTS: The results of @entity3 - @entity4 assay had significant correlation with clinical outcome. The clinical chemotherapy outcome became better with increased drug sensitivity in vitro (  (2) = 9.066, P = 0.004). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate for @entity3 - @entity4 method to predict the clinical chemotherapy sensitivity of REOC were 87.5%, 45.9%, 58.3%, 80.9% and 65.2%, respectively. The mean PFS of strong sensitive group, moderately sensitive group and resistant group were 187.1 days, 195.0 days and 60.3 days, respectively. The mean OS were 476.7, 335.7 and 237.5 days, respectively, following the start of @entity4 -directed therapy. The PFS and OS of the two sensitivity groups in vitro were significantly longer than that of the in vitro-resistant group (P < 0.01). CONCLUSION: The results of @entity3 - @entity4 assay are well correlated with clinical treatment responses. The assay may be an important and useful method for individualized chemotherapy for recurrent @entity2 .

title: [Application of @entity3 - XXXX chemosensitivity assay in recurrent @entity2 ].

answer: @entity1


abstract: OBJECTIVE: To explore the value of @entity3 - @entity1 chemosensitivity assay ( @entity3 - @entity4 ) in individualized treatment of recurrent @entity2 (REOC), and to evaluate the correlation between the in vitro chemosensitivity assay and clinical drug sensitivity. METHODS: Sixty-nine REOC specimens were tested by @entity3 - @entity4 assay retrospectively. The @entity0 were divided into strong sensitive, moderate sensitively and resistant groups according to the @entity3 - @entity4 assay results. The clinical results were evaluated according to imaging and serum @entity5 analysis. The correlation between in vitro @entity3 - @entity4 assay and clinical outcome was statistically analyzed by   (2) test. The progression free survival (PFS) and overall survival (OS) of each group were analyzed using Kaplan-Meier method. RESULTS: The results of @entity3 - @entity4 assay had significant correlation with clinical outcome. The clinical chemotherapy outcome became better with increased drug sensitivity in vitro (  (2) = 9.066, P = 0.004). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate for @entity3 - @entity4 method to predict the clinical chemotherapy sensitivity of REOC were 87.5%, 45.9%, 58.3%, 80.9% and 65.2%, respectively. The mean PFS of strong sensitive group, moderately sensitive group and resistant group were 187.1 days, 195.0 days and 60.3 days, respectively. The mean OS were 476.7, 335.7 and 237.5 days, respectively, following the start of @entity4 -directed therapy. The PFS and OS of the two sensitivity groups in vitro were significantly longer than that of the in vitro-resistant group (P < 0.01). CONCLUSION: The results of @entity3 - @entity4 assay are well correlated with clinical treatment responses. The assay may be an important and useful method for individualized chemotherapy for recurrent @entity2 .

title: [Application of @entity3 - @entity1 chemosensitivity assay in recurrent XXXX ].

answer: @entity2


abstract: Sleep behavior between 1/2 and 5 years in 320 Swiss @entity0 of the first Zurich longitudinal study is reported. The average length of night sleep between 1/2 and 5 years was 11 to 12 hours. Day sleep was noted in 96% of the @entity0 between 6 and 24 months, and in 20% at age 5. The total length of sleep between 6 and 18 months was 15 hours per 24 hours. It diminished to 12 hours at age 5. There was a large individual variability of day sleep and of night sleep at all ages. Positive correlations were found between the lengths of day sleep at different ages and between the lengths of night sleep at different ages. The length of day sleep and that of night sleep was negatively correlated between 2 and 5 years. Evening wakefulness was observed in 16% and night waking in 40 to 50% of all @entity0 . 18% woke up at least once each night. Night wakening between 2 and 5 years was positively correlated. In about half of the @entity0 with evening wakefulness and/or night wakening these @entity1 were considered as abnormal by the mothers.

title: [The development of XXXX within the first 5 years of life].

answer: @entity1


abstract: Superior insights into molecular mechanisms of @entity7 , which are not fully understood, will help strategies for inducing @entity3 . We examined hepatotoxic mechanisms in @entity0 homozygous for the severe combined @entity10 mutation in the protein kinase, DNA-activated, catalytic polypeptide. @entity0 were treated with @entity6 , @entity9 , and @entity11 . The ensuing @entity4 was characterized by serological, histological, and mRNA studies. Subsequently, we studied whether transplantation of hepatocytes could rescue animals with @entity7 . We found extensive @entity3 in these animals, with mortality over several days. The expression of multiple hepatic genes was rapidly altered, including those representing pathways in oxidative/metabolic stress, @entity1 , DNA damage-repair, and @entity5 mutant ( @entity8 ) signaling pathways. This led to liver cell growth arrest involving cyclin-dependent kinase inhibitor 1A. Transplantation of hepatocytes with microcarriers in the peritoneal cavity efficiently rescued animals with @entity7 . @entity2 rapidly reversed, including in hepatic @entity8 and downstream signaling pathways; and residual hepatocytes overcame cyclin-dependent kinase inhibitor 1A-induced cell growth arrest. Reseeding of the liver with transplanted hepatocytes was not required for rescue because native hepatocytes overcame cell growth-arrest to regenerate the liver. This likely resulted from paracrine signaling from hepatocytes in the peritoneal cavity. We concluded that @entity8 signaling played critical roles in the pathological features of @entity7 . These studies should help redirect examination of pathophysiologic and therapeutic mechanisms in @entity7 .

title: Perturbations in XXXX mutant signaling pathways after drug-induced @entity4 and their reversal during rescue of animals by cell therapy.

answer: @entity5


abstract: Superior insights into molecular mechanisms of @entity7 , which are not fully understood, will help strategies for inducing @entity3 . We examined hepatotoxic mechanisms in @entity0 homozygous for the severe combined @entity10 mutation in the protein kinase, DNA-activated, catalytic polypeptide. @entity0 were treated with @entity6 , @entity9 , and @entity11 . The ensuing @entity4 was characterized by serological, histological, and mRNA studies. Subsequently, we studied whether transplantation of hepatocytes could rescue animals with @entity7 . We found extensive @entity3 in these animals, with mortality over several days. The expression of multiple hepatic genes was rapidly altered, including those representing pathways in oxidative/metabolic stress, @entity1 , DNA damage-repair, and @entity5 mutant ( @entity8 ) signaling pathways. This led to liver cell growth arrest involving cyclin-dependent kinase inhibitor 1A. Transplantation of hepatocytes with microcarriers in the peritoneal cavity efficiently rescued animals with @entity7 . @entity2 rapidly reversed, including in hepatic @entity8 and downstream signaling pathways; and residual hepatocytes overcame cyclin-dependent kinase inhibitor 1A-induced cell growth arrest. Reseeding of the liver with transplanted hepatocytes was not required for rescue because native hepatocytes overcame cell growth-arrest to regenerate the liver. This likely resulted from paracrine signaling from hepatocytes in the peritoneal cavity. We concluded that @entity8 signaling played critical roles in the pathological features of @entity7 . These studies should help redirect examination of pathophysiologic and therapeutic mechanisms in @entity7 .

title: Perturbations in @entity5 mutant signaling pathways after drug-induced XXXX and their reversal during rescue of animals by cell therapy.

answer: @entity4


abstract: Forty-five @entity0 with @entity6 ( @entity6 ) were reviewed. The preexcitation using Boineau's classification was: right anterior (six @entity0 ), left lateral (nine @entity0 ), right posterior (15 @entity0 ) and left posterior (15 @entity0 ). Normal pathway conduction was observed to occur either spontaneously or after administration of @entity7 , @entity3 , or by eye-ball pressure. Disappearance of preexcitation was associated with T wave abnormalities in 39 @entity0 (86.6%). The orientation of the T @entity5 ( @entity5 ), after suppression of the @entity6 aspect, varied according to the site of ventricular preexcitation. In eight @entity0 with left lateral ventricular preexcitation (LLVP), the frontal T wave @entity4 was between +70 degrees and +120 degrees (mean +92 degrees) and the horizontal T wave @entity4 was located in the left anterior quadrant. In the five @entity0 with right anterior ventricular preexcitation (RAVP), the frontal @entity4 was between + 40 degrees and - 10 degrees (mean + 26 degrees) and the horizontal @entity4 was in the left posterior quadrant. The 26 cases with right posterior ventricular preexcitation (RPVP) and left posterior ventricular preexcitation (LPVP) had a frontal @entity4 between - 10 degrees and - 70 degrees (mean -39 degrees) and the horizontal T wave @entity4 in the left anterior quadrant. This study suggests that the T wave anomalies observed after suppression of the @entity6 aspect are in direct relation to the localization of the preexcitation according to Boineau's classification. The analogy between the abnormalities of the T wave and those which are observed after right @entity1 ( @entity1 ) or after disappearance of @entity2 ( @entity2 ) is discussed.

title: XXXX : T wave abnormalities during normal pathway conduction.

answer: @entity6


abstract: Corrective surgery for @entity3 under local anaesthesia as day cases was carried out on 162 @entity0 . All had 10 to 14 mm resection of the levator complex with an attached 2 mm strip of tarsal plate, always via a conjunctival approach. If indicated, simultaneous blepharoplasty was also performed. To simplify the surgical and parasurgical management, the author has progressively introduced modifications in the techniques of local anaesthesia, and in the surgical technique. These enable clear and clean isolation of the various tissue planes. The local anaesthesia including facial @entity2 is given at least 30 minutes pre-operatively to prevent @entity4 . Orbital compression is applied to achieve orbital decongestion, and an @entity1 avascular surgical field. This coupled with the use of microsurgical instruments for surgery under 3 times spectacle magnification allows proper delineation of surgical planes. The average surgical time is 20 minutes. @entity0 are allowed home within 2 hours of surgery, are seen for first dressing at 48 hours, and then for suture removal on the 7th post-operative day. There have been no corneal or other complications in any @entity0 . Suboptimal cosmetic results in 2 @entity0 were corrected by further surgery under local anaesthesia as day cases.

title: Day surgery management of XXXX .

answer: @entity3


abstract: A 54-yr-old @entity0 was admitted to Hokkaido University Hospital, complaining of @entity5 , multiple @entity11 , @entity1 erythema and face and @entity7 of extremities during the last 2 months. He was diagnosed as @entity12 by acceleration of ESR, elevation of GOT, @entity13 , @entity14 , aldolase, moderate increases of collagen fibers in biopsy specimen of skin and his clinical signs. Although stools were positive for occult blood, the routine radiographic examination failed to detect the bleeding site in the upper GI. tract. However, in the double contrast picture of the @entity10 , a very fine abnormal linear shadow was observed at the upper corpus of the lesser curvature. This linear shadow was a margin of the @entity2 , retrospectively. About 4 months later, abnormal @entity3 occurred and a mass was palpable in the left lumbar region, suggesting a @entity8 . He was operated on excising the @entity2 , but was performed only exploratory laparotomy because of the presence of intra-abdominal metastases. @entity4 occurred 40 days after the operation and necropsy was done. The gross anatomical findings of the abdomen showed a @entity2 as large as an @entity0 's head and its metastases to pancreas, lymph nodes, and greater and lesser omentum. Esophageal mucosa including esophagocardiac junction was intact. Histological examination of the intragastric @entity2 revealed a typical @entity9 with keratinization. According to the absence of the components of @entity6 and squamous metaplastic gastric mucosa of non-cancerous areas in the @entity10 , it seemed likely to be a @entity9 . It was unknown about the precedence between the @entity2 and @entity12 . There have been 11 cases of primary @entity9 in the world literature since 1968, but this is the first case report of coexistence of these two diseases.

title: [A case report of a primary XXXX of the @entity10 associated with @entity12 (author's transl)].

answer: @entity9


abstract: A 54-yr-old @entity0 was admitted to Hokkaido University Hospital, complaining of @entity5 , multiple @entity11 , @entity1 erythema and face and @entity7 of extremities during the last 2 months. He was diagnosed as @entity12 by acceleration of ESR, elevation of GOT, @entity13 , @entity14 , aldolase, moderate increases of collagen fibers in biopsy specimen of skin and his clinical signs. Although stools were positive for occult blood, the routine radiographic examination failed to detect the bleeding site in the upper GI. tract. However, in the double contrast picture of the @entity10 , a very fine abnormal linear shadow was observed at the upper corpus of the lesser curvature. This linear shadow was a margin of the @entity2 , retrospectively. About 4 months later, abnormal @entity3 occurred and a mass was palpable in the left lumbar region, suggesting a @entity8 . He was operated on excising the @entity2 , but was performed only exploratory laparotomy because of the presence of intra-abdominal metastases. @entity4 occurred 40 days after the operation and necropsy was done. The gross anatomical findings of the abdomen showed a @entity2 as large as an @entity0 's head and its metastases to pancreas, lymph nodes, and greater and lesser omentum. Esophageal mucosa including esophagocardiac junction was intact. Histological examination of the intragastric @entity2 revealed a typical @entity9 with keratinization. According to the absence of the components of @entity6 and squamous metaplastic gastric mucosa of non-cancerous areas in the @entity10 , it seemed likely to be a @entity9 . It was unknown about the precedence between the @entity2 and @entity12 . There have been 11 cases of primary @entity9 in the world literature since 1968, but this is the first case report of coexistence of these two diseases.

title: [A case report of a primary @entity9 of the @entity10 associated with XXXX (author's transl)].

answer: @entity12


abstract: A 54-yr-old @entity0 was admitted to Hokkaido University Hospital, complaining of @entity5 , multiple @entity11 , @entity1 erythema and face and @entity7 of extremities during the last 2 months. He was diagnosed as @entity12 by acceleration of ESR, elevation of GOT, @entity13 , @entity14 , aldolase, moderate increases of collagen fibers in biopsy specimen of skin and his clinical signs. Although stools were positive for occult blood, the routine radiographic examination failed to detect the bleeding site in the upper GI. tract. However, in the double contrast picture of the @entity10 , a very fine abnormal linear shadow was observed at the upper corpus of the lesser curvature. This linear shadow was a margin of the @entity2 , retrospectively. About 4 months later, abnormal @entity3 occurred and a mass was palpable in the left lumbar region, suggesting a @entity8 . He was operated on excising the @entity2 , but was performed only exploratory laparotomy because of the presence of intra-abdominal metastases. @entity4 occurred 40 days after the operation and necropsy was done. The gross anatomical findings of the abdomen showed a @entity2 as large as an @entity0 's head and its metastases to pancreas, lymph nodes, and greater and lesser omentum. Esophageal mucosa including esophagocardiac junction was intact. Histological examination of the intragastric @entity2 revealed a typical @entity9 with keratinization. According to the absence of the components of @entity6 and squamous metaplastic gastric mucosa of non-cancerous areas in the @entity10 , it seemed likely to be a @entity9 . It was unknown about the precedence between the @entity2 and @entity12 . There have been 11 cases of primary @entity9 in the world literature since 1968, but this is the first case report of coexistence of these two diseases.

title: [A case report of a primary @entity9 of the XXXX associated with @entity12 (author's transl)].

answer: @entity10


abstract: The influence of interactions between dietary fat and protein on spontaneous diseases was investigated in @entity4 fed two levels of @entity13 oil [4.5 or 18 g/385 kilocalories (kcal)] with each of two levels of casein (9 or 36 g/385 kcal). The four diets were fed to separate groups in two different sequences: 1) Diets were given during weeks 3-7 and followed by control diet (9 g @entity13 oil and 18 g casein/385 kcal), or 2) control diet was fed during weeks 3-7, and the four diets were fed from week 8 until @entity3 . Dietary interactions of fat and protein modified spontaneous degenerative, inflammatory, and @entity1 in hamsters. For example, @entity6 , spleen, and adrenal glands was reduced in females by feeding @entity11 ( @entity11 ) diet in comparison with low-fat-high-protein (LF-HP) diet during weeks 3-7 or by feeding LP diets at either fat level after 8 weeks. The incidence of @entity2 was highest in males consuming HP diet at either fat level after 8 weeks, and @entity2 was observed most often in hamsters fed @entity11 diet after 8 weeks. Gastric and renal @entity7 and @entity14 incidences were reduced by 50-100% in hamsters fed @entity11 diet after 8 weeks, and HF diet fed at this time reduced @entity7 in the heart in both sexes and in the lungs in males. @entity0 was generally influenced similarly by diets fed either during weeks 3-7 or after 8 weeks. In the prostate gland, @entity0 was observed most frequently in males fed HF-LP diet; however, in the vagina @entity0 was elevated in females fed @entity11 diet and found in the gallbladder more commonly in hamsters fed @entity11 than in those given LF-HP. The incidence of @entity10 was decreased by giving HF-LP diet during weeks 3-7 or LF-LP diets after week 8. The incidence of gastric @entity9 was high in males fed HF diets during weeks 3-7, and intestinal @entity9 were high in those fed LF-LP at this time. The @entity8 incidence was highest in males given @entity11 diet before or after 8 weeks and in females given this diet after 8 weeks. Similarly, @entity12 was highest in females fed @entity11 diet after 8 weeks, and @entity5 increased with the rise in fat at both protein levels in both sexes.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Interaction of dietary fat and protein in spontaneous diseases of XXXX .

answer: @entity4


abstract: PURPOSE: Biologic prostheses are designed to support tissue regeneration rather than just result in a strong scar plate, as is the case with synthetic mesh. It is not known if these newer materials will result in earlier return to normal activities and/or less post-herniorrhaphy groin @entity1 . METHOD/STUDY DESIGN: A prospective, randomized, controlled, third-party-blinded multicenter trial was designed to compare the use of a non-cross linked porcine dermis biologic graft [Strattice(TM) Reconstructive Tissue Matrix (RTM), LifeCell, Branchburg, NJ] versus light weight, large pore @entity6 mesh (UltraPro(TM), Ethicon, Somerville, NJ). The study design called for recruitment of 170 @entity0 . These @entity0 are being followed for a minimum of 2  years. The primary aim of this study is to compare the safety and effectiveness of the two materials in a @entity2 as measured by resumption of activities of daily living. Secondary outcomes include @entity5 , @entity3 and the incidence of re-herniation at 12 and 24  months. RESULTS: This paper discusses the study design, @entity0 recruitment and the current status of the clinical trial. The study involves nine medical centers, all with extensive experience in @entity4 repair. After 24  months of enrollment, 172 @entity0 were randomized and recruitment was then closed. All @entity0 underwent elective repair of primary unilateral @entity2 as an outpatient operation. Follow up data are being collected. Data analyses are scheduled at 3, 12, and 24  months postoperatively. CONCLUSION: We report the design of a multi-center, third-party blinded, randomized clinical trial comparing a new surgical device with existing technology in the repair of @entity2 . We believe this investigator-designed and conducted trial could serve as a model for similar trials examining surgical devices performed in collaboration with industry.

title: The design of an industry-sponsored randomized controlled trial to compare synthetic mesh versus biologic mesh for XXXX .

answer: @entity2


abstract: BACKGROUND: Improvements in technology play an important role in caring for critically ill @entity0 . One example is the advance in ventilator design to facilitate triggering of mechanical breaths. Minimal changes in circuit flow unrelated to respiratory effort can trigger a ventilator breath and may mislead caregivers in recognizing @entity3 . METHODS: We observed @entity0 with devastating @entity2 in a mixed medical/surgical intensive care unit (ICU) with a high clinical suspicion for @entity3 including the absence of cranial nerve function with apparent spontaneous breathing during @entity0 -triggered modes of mechanical ventilation. Further clinical observation for spontaneous respirations was assessed upon removal of ventilatory support. RESULTS: Nine @entity0 with @entity2 due to multiple etiologies were identified and demonstrated no spontaneous respirations when formally assessed for @entity1 . Length of time between @entity3 and its recognition could not be determined. CONCLUSION: When @entity3 @entity0 who are suitable organ donors are mistakenly identified as having cerebral activity, the diagnosis of @entity3 is delayed. This delay impacts resource utilization, impedes recovery and function of organs for donation, and adversely affects donor families, potential recipients of organs, and @entity0 donors who may have testing and treatment that cannot be beneficial. @entity0 with catastrophic @entity2 and absent cranial nerve function should undergo immediate formal @entity1 testing.

title: Ventilator autocycling and delayed recognition of XXXX .

answer: @entity3


abstract: BACKGROUND: Binge drinking is common in @entity0 adolescents. The adolescent brain is undergoing structural maturation and has a unique sensitivity to @entity2 @entity7 . Therefore, adolescent binge @entity5 may have long-term effects on the adult brain that alter brain structure and behaviors that are relevant to @entity2 -use disorders. METHODS: To determine whether adolescent @entity5 (AE) binge drinking alters the adult brain, male C57BL/6 @entity1 were treated with either water or @entity5 during adolescence (5 g/kg/d, i.g., postnatal days @entity10 to @entity11 ) and assessed during adulthood ( @entity9 to P88). An array of neurotransmitter-specific genes, behavioral tests (i.e., reversal learning, prepulse inhibition, and open field), and postmortem brain structure using magnetic resonance imaging (MRI) and immunohistochemistry, were employed to assess persistent alterations in adult brain. RESULTS: At @entity6 , 24 hours after AE binge, many neurotransmitter genes, particularly cholinergic and dopaminergic, were reduced by @entity5 treatment. Interestingly, @entity4 receptor type 4 mRNA was reduced and confirmed using immunohistochemistry. Normal control maturation ( @entity6 to P88) resulted in decreased neurotransmitter mRNA, e.g., an average decrease of 56%. Following AE treatment, adults showed greater gene expression reductions than controls, averaging 73%. Adult spatial learning assessed in the Morris water maze was not changed by AE treatment, but reversal learning experiments revealed deficits. Assessment of adult brain region volumes using MRI indicated that the olfactory bulb and basal forebrain were smaller in adults following AE. Immunohistochemical analyses found reduced basal forebrain area and fewer basal forebrain cholinergic neurons. CONCLUSIONS: Adolescent binge @entity5 treatment reduces adult neurotransmitter gene expression, particularly cholinergic genes, reduces basal forebrain and olfactory bulb volumes, and causes a reduction in the density of basal forebrain @entity3 neurons. Loss of cholinergic neurons and forebrain structure could underlie adult reversal @entity8 following adolescent binge drinking.

title: Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in XXXX .

answer: @entity1


abstract: Aortic proteoglycans (PG) were isolated from @entity0 aorta intima-media preparations with 4 M @entity2 in the presence of protease inhibitors. The extracted PG mixture comprised 67% of the total aortic PG and was composed of 65% chondroitin @entity1 , 22% dermatan @entity1 , 8% heparan @entity1 , and 4% @entity5 . Attempts at isolation and purification of PG monomers using isopycnic @entity3 gradient centrifugation under associative and dissociative conditions resulted in appreciable loss of PG through associations with co-extracted aortic proteins. The addition of a gel chromatographic step on Sepharose CL-4B under dissociative conditions resulted in separation of PG from the majority of co-extracted proteins. In addition, the procedure resulted in a separation of the PG into a population ( @entity4 ) eluting near the column V0 and one ( @entity6 ) included with a Kav of 0.38. Hyaluronic acid co-eluted with @entity4 . The major glycosaminoglycan in @entity4 was chondroitin @entity1 , (85 to 95%). No dermatan @entity1 was detected in @entity4 , but this glycosaminoglycan was the predominant glycosaminoglycan in @entity6 (50 to 70%). Heparan @entity1 was present in small amounts in both @entity4 and @entity6 . Data presented support the proposal of at least three species of PG monomers in the aortic wall. Chromatographic studies under dissociative and associative conditions indicated that PG comprising @entity4 but not @entity6 were capable of associations with hyaluronic acid.

title: Isolation and preliminary characterization of proteoglycans dissociatively extracted from XXXX aorta.

answer: @entity0


abstract: The analysis of @entity1 in unifloral honeys by high-performance liquid chromatography (HPLC) coupled with coulometric electrode array detection (CEAD) is described. The compounds were extracted by a nonionic polymeric resin (Amberlite XAD-2) and then separated on a reversed phase column using gradient elution. @entity2 , @entity7 , @entity8 , @entity6 , @entity5 , @entity10 , and @entity9 were detected in a coulometric electrode array detection system between +300 and +800 mV against @entity4 reference electrodes, and their presence was additionally confirmed by HPLC coupled with electrospray ionization mass spectrometry. The method was applied to analysis of 19 honeys of different varieties and origin. The limits of detection and quantitation ranged between 1.6 and 8.3  g/kg and 3.9 and 27.4  g/kg, respectively. The recoveries were above 96% in fluid and above 89% in creamy honeys. Some of these honeys ( @entity0 , pumpkin, cherry blossom, dandelion, maple, and pine tree honey) were investigated for their @entity3 content and profile for the first time. Differences between honeys were observed both in @entity3 concentrations and in the @entity3 profiles. The @entity3 concentrations ranged from 0.015 to 3.4 mg/kg honey. @entity9 , @entity5 , @entity2 , @entity10 , and @entity6 were detected in all investigated honeys, whereas @entity8 occurred only in lemon and orange honeys and @entity7 in lemon, orange, rhododendron, rosemary, and cherry blossom honeys.

title: Analysis of XXXX in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry.

answer: @entity1


abstract: PURPOSE: to evaluate the biological and clinical implications of @entity1 of bone marrow myeloid cell compartment in @entity0 with primary @entity6 ( @entity6 ). METHODS: analysis of @entity8 profiles was performed by flow cytometric immunophenotyping on bone marrow mononuclear cell (BMMNCs) specimens from 39 adult @entity6 @entity0 and 5 healthy individuals. Expression of @entity8 profiles was correlated with @entity13 subtype, cytogenetics, CFU-GM colony growth, @entity3 ( @entity3 ) and leukemic transformation (LT). RESULTS: expression levels of early differentiation and myelo-monocytic antigens ( @entity7 , @entity12 , @entity2 , @entity9 and @entity10 ) on myeloid cell compartment of BMMCs were significantly higher in @entity6 @entity0 in comparison to healthy control group, suggesting maturational left shift of bone marrow myeloid cell compartment in @entity6 . @entity5 antigen expression was in a positive linear correlation with HLA-DR antigen expression (r=0.652; p=0.0004), and in negative correlation with the expression of @entity11 and @entity10 antigens (r=-0.48; p=0.014 and r=-0.564; p=0.0033, respectively). Myeloid antigen ratio (HLA-DR/ @entity11 ) was 2.5 fold higher in @entity0 with @entity6 in comparison to control group. @entity0 with @entity4 had significantly higher myeloid antigen ratio than @entity0 with low risk @entity6 (p<0.05). The type of CFU-GM colony growth and the presence of chromosomal aberrations were unrelated to the proportion of @entity5 (+) cells and elevated myeloid ratio. @entity0 with elevated proportion of @entity5 (+) BMMNCs or elevated myeloid ratio had significantly shorter @entity3 and higher LT rate in comparison to @entity0 whose proportion of @entity5 (+) BMMNCs and myeloid ratio were within normal range. CONCLUSION: the presence of abnormalities in antigen expression profiles of bone marrow myeloid cell compartment has clinical implication in @entity6 , with particular contribution in predicting the @entity0 outcome. Elevated proportion of @entity5 (+) BMMNCs and elevated myeloid ratio of bone marrow myeloid compartment are useful immunophenotypic tools for estimation of prognosis in this very heterogeneous disorder group.

title: Clinical implications of XXXX of bone marrow myeloid cell compartment in @entity6 .

answer: @entity1


abstract: PURPOSE: to evaluate the biological and clinical implications of @entity1 of bone marrow myeloid cell compartment in @entity0 with primary @entity6 ( @entity6 ). METHODS: analysis of @entity8 profiles was performed by flow cytometric immunophenotyping on bone marrow mononuclear cell (BMMNCs) specimens from 39 adult @entity6 @entity0 and 5 healthy individuals. Expression of @entity8 profiles was correlated with @entity13 subtype, cytogenetics, CFU-GM colony growth, @entity3 ( @entity3 ) and leukemic transformation (LT). RESULTS: expression levels of early differentiation and myelo-monocytic antigens ( @entity7 , @entity12 , @entity2 , @entity9 and @entity10 ) on myeloid cell compartment of BMMCs were significantly higher in @entity6 @entity0 in comparison to healthy control group, suggesting maturational left shift of bone marrow myeloid cell compartment in @entity6 . @entity5 antigen expression was in a positive linear correlation with HLA-DR antigen expression (r=0.652; p=0.0004), and in negative correlation with the expression of @entity11 and @entity10 antigens (r=-0.48; p=0.014 and r=-0.564; p=0.0033, respectively). Myeloid antigen ratio (HLA-DR/ @entity11 ) was 2.5 fold higher in @entity0 with @entity6 in comparison to control group. @entity0 with @entity4 had significantly higher myeloid antigen ratio than @entity0 with low risk @entity6 (p<0.05). The type of CFU-GM colony growth and the presence of chromosomal aberrations were unrelated to the proportion of @entity5 (+) cells and elevated myeloid ratio. @entity0 with elevated proportion of @entity5 (+) BMMNCs or elevated myeloid ratio had significantly shorter @entity3 and higher LT rate in comparison to @entity0 whose proportion of @entity5 (+) BMMNCs and myeloid ratio were within normal range. CONCLUSION: the presence of abnormalities in antigen expression profiles of bone marrow myeloid cell compartment has clinical implication in @entity6 , with particular contribution in predicting the @entity0 outcome. Elevated proportion of @entity5 (+) BMMNCs and elevated myeloid ratio of bone marrow myeloid compartment are useful immunophenotypic tools for estimation of prognosis in this very heterogeneous disorder group.

title: Clinical implications of @entity1 of bone marrow myeloid cell compartment in XXXX .

answer: @entity6


abstract: The effects of long-term (10 years) management at a special out- @entity0 @entity3 clinic with respect to dropout rate, side effects, blood pressure (BP) control, target organ involvement, prognostic factors and @entity2 have been studied in 686 middle-aged male @entity3 . The impact of antihypertensive treatment, as one ingredient of multiple risk factor intervention, on mortality and morbidity in an urban, male population have been analysed. The @entity3 @entity0 were derived from a random sample of @entity0 , aged 47-54 years at entry, constituting the intervention group (n = 7,455) of a multifactorial primary prevention trail. The whole population sample was studied regarding the effect of treatment on morbidity. The 10-year drop-out rate (declined follow-up/unknown reasons) was low (5%) being highest during the first year. The frequency of severe adverse drug effects was low (3% per year) after the initial period when treatment was started. An acceptable BP reduction was achieved in the majority of @entity0 , but in many cases first after a few years' treatment and requiring combination drug therapy. Two-thirds of the @entity0 achieved the goal BP (i.e. less than 160/95 mm Hg). These results are attributed to the organisation of the clinic and emphasise the need for frequent check-ups during the early phase of treatment and an easy accessibility to nurses and physicians. Except for a significant regression of ST- and T-wave changes on the conventional ECG during the first treatment year signs of heart (conventional ECG, chest X-ray) and kidney ( @entity7 , serum @entity11 ) involvement remained unchanged or increased slightly during follow-up. @entity10 ( @entity10 ), @entity6 ( @entity6 ) and @entity9 ( @entity9 ) were common complications. The prevalence increased steadily with an average annual incidence of 1.3% ( @entity10 ), 0.6% ( @entity6 ) and 0.6% ( @entity9 ). ECG signs indicating subclinical @entity5 were risk factor for @entity10 and @entity9 . Smoking was an independent risk factor for any one of these @entity2 . The 10-year incidence of total mortality was 11.1%, and of CHD and @entity1 morbidity 12.2% and 4.1%, respectively. Independent risk factors (entry variables) for CHD were diastolic BP, smoking, serum @entity4 , @entity10 and @entity8 . A previous @entity1 , smoking and @entity8 were independently associated with @entity1 morbidity. Hence, the risk factor pattern was similar to that known to operate in the general population.(ABSTRACT TRUNCATED AT 400 WORDS)

title: XXXX in middle-aged @entity0 . Management, morbidity and prognostic factors during long-term @entity3 care.

answer: @entity3


abstract: The effects of long-term (10 years) management at a special out- @entity0 @entity3 clinic with respect to dropout rate, side effects, blood pressure (BP) control, target organ involvement, prognostic factors and @entity2 have been studied in 686 middle-aged male @entity3 . The impact of antihypertensive treatment, as one ingredient of multiple risk factor intervention, on mortality and morbidity in an urban, male population have been analysed. The @entity3 @entity0 were derived from a random sample of @entity0 , aged 47-54 years at entry, constituting the intervention group (n = 7,455) of a multifactorial primary prevention trail. The whole population sample was studied regarding the effect of treatment on morbidity. The 10-year drop-out rate (declined follow-up/unknown reasons) was low (5%) being highest during the first year. The frequency of severe adverse drug effects was low (3% per year) after the initial period when treatment was started. An acceptable BP reduction was achieved in the majority of @entity0 , but in many cases first after a few years' treatment and requiring combination drug therapy. Two-thirds of the @entity0 achieved the goal BP (i.e. less than 160/95 mm Hg). These results are attributed to the organisation of the clinic and emphasise the need for frequent check-ups during the early phase of treatment and an easy accessibility to nurses and physicians. Except for a significant regression of ST- and T-wave changes on the conventional ECG during the first treatment year signs of heart (conventional ECG, chest X-ray) and kidney ( @entity7 , serum @entity11 ) involvement remained unchanged or increased slightly during follow-up. @entity10 ( @entity10 ), @entity6 ( @entity6 ) and @entity9 ( @entity9 ) were common complications. The prevalence increased steadily with an average annual incidence of 1.3% ( @entity10 ), 0.6% ( @entity6 ) and 0.6% ( @entity9 ). ECG signs indicating subclinical @entity5 were risk factor for @entity10 and @entity9 . Smoking was an independent risk factor for any one of these @entity2 . The 10-year incidence of total mortality was 11.1%, and of CHD and @entity1 morbidity 12.2% and 4.1%, respectively. Independent risk factors (entry variables) for CHD were diastolic BP, smoking, serum @entity4 , @entity10 and @entity8 . A previous @entity1 , smoking and @entity8 were independently associated with @entity1 morbidity. Hence, the risk factor pattern was similar to that known to operate in the general population.(ABSTRACT TRUNCATED AT 400 WORDS)

title: @entity3 in middle-aged @entity0 . Management, morbidity and prognostic factors during long-term XXXX care.

answer: @entity3


abstract: The effects of long-term (10 years) management at a special out- @entity0 @entity3 clinic with respect to dropout rate, side effects, blood pressure (BP) control, target organ involvement, prognostic factors and @entity2 have been studied in 686 middle-aged male @entity3 . The impact of antihypertensive treatment, as one ingredient of multiple risk factor intervention, on mortality and morbidity in an urban, male population have been analysed. The @entity3 @entity0 were derived from a random sample of @entity0 , aged 47-54 years at entry, constituting the intervention group (n = 7,455) of a multifactorial primary prevention trail. The whole population sample was studied regarding the effect of treatment on morbidity. The 10-year drop-out rate (declined follow-up/unknown reasons) was low (5%) being highest during the first year. The frequency of severe adverse drug effects was low (3% per year) after the initial period when treatment was started. An acceptable BP reduction was achieved in the majority of @entity0 , but in many cases first after a few years' treatment and requiring combination drug therapy. Two-thirds of the @entity0 achieved the goal BP (i.e. less than 160/95 mm Hg). These results are attributed to the organisation of the clinic and emphasise the need for frequent check-ups during the early phase of treatment and an easy accessibility to nurses and physicians. Except for a significant regression of ST- and T-wave changes on the conventional ECG during the first treatment year signs of heart (conventional ECG, chest X-ray) and kidney ( @entity7 , serum @entity11 ) involvement remained unchanged or increased slightly during follow-up. @entity10 ( @entity10 ), @entity6 ( @entity6 ) and @entity9 ( @entity9 ) were common complications. The prevalence increased steadily with an average annual incidence of 1.3% ( @entity10 ), 0.6% ( @entity6 ) and 0.6% ( @entity9 ). ECG signs indicating subclinical @entity5 were risk factor for @entity10 and @entity9 . Smoking was an independent risk factor for any one of these @entity2 . The 10-year incidence of total mortality was 11.1%, and of CHD and @entity1 morbidity 12.2% and 4.1%, respectively. Independent risk factors (entry variables) for CHD were diastolic BP, smoking, serum @entity4 , @entity10 and @entity8 . A previous @entity1 , smoking and @entity8 were independently associated with @entity1 morbidity. Hence, the risk factor pattern was similar to that known to operate in the general population.(ABSTRACT TRUNCATED AT 400 WORDS)

title: @entity3 in middle-aged XXXX . Management, morbidity and prognostic factors during long-term @entity3 care.

answer: @entity0


abstract: Tamm-Horsfall protein ( @entity4 ) is a glycoprotein expressed exclusively in thick ascending limbs (TAL) of the kidney. We recently described a novel protective role of @entity4 against @entity3 ( @entity3 ) via downregulation of @entity1 in the outer medulla. Our current study investigates the mechanistic relationships among the status of @entity4 , @entity1 , and @entity3 . Using an @entity2 -reperfusion model in wild-type and @entity4 -/- @entity0 , we demonstrate that it is the S3 proximal segments but not the @entity4 -deficient TAL that are the main targets of @entity3 during @entity3 . The injured S3 segments that are surrounded by neutrophils in @entity4 -/- @entity0 have marked overexpression of neutrophil chemoattractant @entity5 compared with wild-type counterparts. Neutralizing @entity5 ( @entity5 ) antibody rescues S3 segments from injury, decreases neutrophil infiltration, and improves kidney function in @entity4 -/- @entity0 . Furthermore, using immunofluorescence volumetric imaging of wild-type @entity0 kidneys, we show that @entity2 alters the intracellular translocation of @entity4 in the TAL cells by partially shifting it from its default apical surface domain to the basolateral domain, the latter being contiguous to the basolateral surface of S3 segments. Concomitant with this is the upregulation, in the basolateral surface of S3 segments, of the scavenger receptor @entity6 , a putative receptor for @entity4 . We conclude that @entity7 affects the susceptibility of S3 segments to injury at least in part by regulating @entity5 expression in a @entity4 -dependent manner. Our findings raise the interesting possibility of a direct role of basolaterally released @entity4 on regulating @entity1 in S3 segments.

title: Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an XXXX -dependent mechanism.

answer: @entity5


abstract: Nontuberculous mycobacteria rarely infect the central nervous system. Recently, Mycobacterium genavense, nontuberculous mycobacterium (NTM), has been identified as a significant pathogen in @entity0 . In this report, we describe multiple @entity5 caused by M. genavense in an immunocompromised host. A 50-year-old @entity0 presented with @entity7 , @entity6 , and @entity4 . He had a @entity3 and a M. genavense @entity2 in the thoracic and abdominal lymph nodes. Magnetic resonance imaging revealed multiple intracranial masses in the subcortical regions with extensive perifocal @entity1 . Laboratory investigations and cultures of cerebrospinal fluid provided no evidence of disseminated @entity2 . We obtained a biopsy sample via a small craniotomy using neuronavigation, and NTM @entity2 was confirmed on analysis of the specimen. He was treated with antimycobacterial agents, and the clinical symptoms and radiological findings improved. Although a surgical procedure bears the potential risk of @entity2 , especially in an immunocompromised @entity0 , a brain biopsy was necessary for definitive diagnosis in this case and it aided in the administration of appropriate treatment.

title: [Multiple infectious XXXX of Mycobacterium genavense in an immunocompromised @entity0 ].

answer: @entity5


abstract: Nontuberculous mycobacteria rarely infect the central nervous system. Recently, Mycobacterium genavense, nontuberculous mycobacterium (NTM), has been identified as a significant pathogen in @entity0 . In this report, we describe multiple @entity5 caused by M. genavense in an immunocompromised host. A 50-year-old @entity0 presented with @entity7 , @entity6 , and @entity4 . He had a @entity3 and a M. genavense @entity2 in the thoracic and abdominal lymph nodes. Magnetic resonance imaging revealed multiple intracranial masses in the subcortical regions with extensive perifocal @entity1 . Laboratory investigations and cultures of cerebrospinal fluid provided no evidence of disseminated @entity2 . We obtained a biopsy sample via a small craniotomy using neuronavigation, and NTM @entity2 was confirmed on analysis of the specimen. He was treated with antimycobacterial agents, and the clinical symptoms and radiological findings improved. Although a surgical procedure bears the potential risk of @entity2 , especially in an immunocompromised @entity0 , a brain biopsy was necessary for definitive diagnosis in this case and it aided in the administration of appropriate treatment.

title: [Multiple infectious @entity5 of Mycobacterium genavense in an immunocompromised XXXX ].

answer: @entity0


abstract: OBJECTIVE: Cross-sectional studies suggest an association between hysterectomy and negative affect. Using prospective data, we examined the associations of negative affect, attitudes toward aging and menopause, @entity4 , and vasomotor symptoms with elective hysterectomy in midlife. METHODS: Data were from the Study of @entity0 's Health Across the Nation, a multisite, community-based prospective cohort study of the menopausal transition (n = 2,818). Annually reported hysterectomy at visits 2 to 9 was verified with medical records when available (71%). @entity1 , perceived stress, @entity2 , attitudes toward aging and menopause, vasomotor symptoms, and @entity4 were assessed at baseline using standardized questions. Cox proportional hazards models were used to relate these variables to subsequent elective hysterectomy. Covariates included demographic variables, @entity3 , body mass index, hormone levels, and self-rated health, also assessed at baseline. RESULTS: Elective hysterectomy was reported by 6% (n = 168) of @entity0 over an 8-year period. @entity0 with hysterectomy were not higher in negative affect or negative attitudes toward aging and menopause compared with @entity0 without hysterectomy. Vasomotor symptoms (hazard ratio [HR], 1.44; 95% CI, 1.03-2.01; P = 0.03) and positive attitudes toward aging and menopause (HR, 1.74; 95% CI, 1.04-2.93) at baseline predicted hysterectomy over the 8-year period, controlling for @entity3 , site, race/ethnicity, follicle-stimulating hormone, age, education, body mass index, and self-rated health. @entity3 at baseline were the strongest predictor of hysterectomy (HR, 4.30; 95% CI, 2.05-9.05). CONCLUSIONS: In this prospective examination, negative affect and attitudes were not associated with subsequent hysterectomy. @entity3 were the major determinant of elective hysterectomy.

title: Negative attitudes and affect do not predict elective hysterectomy: a prospective analysis from the Study of XXXX 's Health Across the Nation.

answer: @entity0


abstract: OBJECTIVE: We wanted to compare the two-dimensional (2D) fast spin echo (FSE) techniques and the three-dimensional (3D) fast field echo techniques for the evaluation of the @entity3 using a microscopy coil. MATERIALS AND METHODS: Twenty five @entity0 who underwent total knee arthroplasty were included in this study. Preoperative MRI evaluation of the patella was performed using a microscopy coil (47 mm). The proton density-weighted fast spin echo images ( @entity2 ), the fat-suppressed @entity2 images (FS- @entity2 ), the intermediate weighted-fat suppressed fast spin echo images (iw-FS-FSE), the 3D balanced-fast field echo images (B-FFE), the 3D water selective cartilage scan (WATS-c) and the 3D water selective fluid scan (WATS-f) were obtained on a 1.5T MRI scanner. The patellar cartilage was evaluated in nine areas: the superior, middle and the inferior portions that were subdivided into the medial, central and lateral facets in a total of 215 areas. Employing the Noyes grading system, the MRI grade 0-I, II and III lesions were compared using the gross and microscopic findings. The sensitivity, specificity and accuracy were evaluated for each sequence. The significance of the differences for the individual sequences was calculated using the McNemar test. RESULTS: The gross and microscopic findings demonstrated 167 grade 0-I lesions, 40 @entity1 and eight @entity1 . Iw-FS-FSE had the highest accuracy (sensitivity/specificity/accuracy = 88%/98%/96%), followed by FS- @entity2 (78%/98%/93%, respectively), @entity2 (76%/98%/93%, respectively), B-FFE (71%/100%/93%, respectively), WATS-c (67%/100%/92%, respectively) and WATS-f (58%/99%/89%, respectively). There were statistically significant differences for the iw-FS-FSE and WATS-f and for the @entity2 -FS and WATS-f (p < 0.01). CONCLUSION: The iw-FS-FSE images obtained with a microscopy coil show best diagnostic performance among the 2D and 3D GRE images for evaluating the @entity3 .

title: Evaluation of the XXXX using a microscopy coil: comparison of the two-dimensional fast spin echo techniques and the three-dimensional fast field echo techniques.

answer: @entity3


abstract: At defined coronal sections, the surface area of infarcted tissue was measured 4 days after the occlusion of the middle artery in 11 @entity3 . In groups of @entity3 treated with @entity6 (5.6 and 16.7 microgram/kg . min over 3 h. 5 min after the occlusion), the infarcted surface was significantly decreased. The topographic localization of the @entity4 was studied in control and treated @entity3 . This established @entity0 was correlated with measures of focal cerebral blood flow and @entity2 consumption 3.5 h after the @entity5 . Grey matter blood flow was universally low in untreated @entity3 , but in @entity3 treated with @entity6 (5.6 microgram/kg . min) cortical and caudate nucleus blood flow was 2-3 times greater, even in those regions that were later infarcted in the treated @entity3 . @entity2 consumption was similarly reduced in untreated @entity3 but there was little difference between the control and drug-treated @entity3 except in some areas where drug treatment appeared to further reduce the values for focal @entity2 consumption. These regions correlated with those in which @entity4 was later found in the @entity3 treated with @entity6 . It is hoped that such correlations between pathology. flow and metabolism could help the search for effective pharmacotherapy of @entity1 .

title: Correlation of local blood flow, XXXX consumption and probability of @entity0 following a @entity5 in the cat.

answer: @entity2


abstract: At defined coronal sections, the surface area of infarcted tissue was measured 4 days after the occlusion of the middle artery in 11 @entity3 . In groups of @entity3 treated with @entity6 (5.6 and 16.7 microgram/kg . min over 3 h. 5 min after the occlusion), the infarcted surface was significantly decreased. The topographic localization of the @entity4 was studied in control and treated @entity3 . This established @entity0 was correlated with measures of focal cerebral blood flow and @entity2 consumption 3.5 h after the @entity5 . Grey matter blood flow was universally low in untreated @entity3 , but in @entity3 treated with @entity6 (5.6 microgram/kg . min) cortical and caudate nucleus blood flow was 2-3 times greater, even in those regions that were later infarcted in the treated @entity3 . @entity2 consumption was similarly reduced in untreated @entity3 but there was little difference between the control and drug-treated @entity3 except in some areas where drug treatment appeared to further reduce the values for focal @entity2 consumption. These regions correlated with those in which @entity4 was later found in the @entity3 treated with @entity6 . It is hoped that such correlations between pathology. flow and metabolism could help the search for effective pharmacotherapy of @entity1 .

title: Correlation of local blood flow, @entity2 consumption and probability of XXXX following a @entity5 in the cat.

answer: @entity0


abstract: At defined coronal sections, the surface area of infarcted tissue was measured 4 days after the occlusion of the middle artery in 11 @entity3 . In groups of @entity3 treated with @entity6 (5.6 and 16.7 microgram/kg . min over 3 h. 5 min after the occlusion), the infarcted surface was significantly decreased. The topographic localization of the @entity4 was studied in control and treated @entity3 . This established @entity0 was correlated with measures of focal cerebral blood flow and @entity2 consumption 3.5 h after the @entity5 . Grey matter blood flow was universally low in untreated @entity3 , but in @entity3 treated with @entity6 (5.6 microgram/kg . min) cortical and caudate nucleus blood flow was 2-3 times greater, even in those regions that were later infarcted in the treated @entity3 . @entity2 consumption was similarly reduced in untreated @entity3 but there was little difference between the control and drug-treated @entity3 except in some areas where drug treatment appeared to further reduce the values for focal @entity2 consumption. These regions correlated with those in which @entity4 was later found in the @entity3 treated with @entity6 . It is hoped that such correlations between pathology. flow and metabolism could help the search for effective pharmacotherapy of @entity1 .

title: Correlation of local blood flow, @entity2 consumption and probability of @entity0 following a XXXX in the cat.

answer: @entity5


abstract: BACKGROUND: Our objective was to evaluate the accuracy of @entity1 ( @entity1 ) risk score classification by direct LDL @entity2 (dLDL-C), calculated LDL @entity2 (cLDL-C), and non-HDL @entity2 (non-HDL-C) compared to classification by reference measurement procedures (RMPs) performed at the CDC. METHODS: We examined 175 individuals, including 138 with @entity1 or conditions that may affect LDL-C measurement. dLDL-C measurements were performed using Denka, Kyowa, Sekisui, Serotec, Sysmex, UMA, and Wako reagents. cLDL-C was calculated by the Friedewald equation, using each manufacturer's direct HDL-C assay measurements, and total @entity2 and @entity3 measurements by Roche and @entity5 (Advia) assays, respectively. RESULTS: For @entity0 with @entity4 <2.26 mmol/L (<200 mg/dL), the overall misclassification rate for the @entity1 risk score ranged from 5% to 17% for cLDL-C methods and 8% to 26% for dLDL-C methods when compared to the RMP. Only Wako dLDL-C had fewer misclassifications than its corresponding cLDL-C method (8% vs 17%; P<0.05). Non-HDL-C assays misclassified fewer @entity0 than dLDL-C for 4 of 8 methods (P<0.05). For @entity0 with @entity4 >= 2.26 mmol/L (>= 200 mg/dL) and<4.52 mmol/L (<400 mg/dL), dLDL-C methods, in general, performed better than cLDL-C methods, and non-HDL-C methods showed better correspondence to the RMP for @entity1 risk score than either dLDL-C or cLDL-C methods. CONCLUSIONS: Except for @entity6 individuals, 7 of 8 dLDL-C methods failed to show improved @entity1 risk score classification over the corresponding cLDL-C methods. Non-HDL-C showed overall the best concordance with the RMP for @entity1 risk score classification of both normal and @entity6 individuals.

title: Non-HDL XXXX shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL @entity2 in a dyslipidemic population.

answer: @entity2


abstract: BACKGROUND: Our objective was to evaluate the accuracy of @entity1 ( @entity1 ) risk score classification by direct LDL @entity2 (dLDL-C), calculated LDL @entity2 (cLDL-C), and non-HDL @entity2 (non-HDL-C) compared to classification by reference measurement procedures (RMPs) performed at the CDC. METHODS: We examined 175 individuals, including 138 with @entity1 or conditions that may affect LDL-C measurement. dLDL-C measurements were performed using Denka, Kyowa, Sekisui, Serotec, Sysmex, UMA, and Wako reagents. cLDL-C was calculated by the Friedewald equation, using each manufacturer's direct HDL-C assay measurements, and total @entity2 and @entity3 measurements by Roche and @entity5 (Advia) assays, respectively. RESULTS: For @entity0 with @entity4 <2.26 mmol/L (<200 mg/dL), the overall misclassification rate for the @entity1 risk score ranged from 5% to 17% for cLDL-C methods and 8% to 26% for dLDL-C methods when compared to the RMP. Only Wako dLDL-C had fewer misclassifications than its corresponding cLDL-C method (8% vs 17%; P<0.05). Non-HDL-C assays misclassified fewer @entity0 than dLDL-C for 4 of 8 methods (P<0.05). For @entity0 with @entity4 >= 2.26 mmol/L (>= 200 mg/dL) and<4.52 mmol/L (<400 mg/dL), dLDL-C methods, in general, performed better than cLDL-C methods, and non-HDL-C methods showed better correspondence to the RMP for @entity1 risk score than either dLDL-C or cLDL-C methods. CONCLUSIONS: Except for @entity6 individuals, 7 of 8 dLDL-C methods failed to show improved @entity1 risk score classification over the corresponding cLDL-C methods. Non-HDL-C showed overall the best concordance with the RMP for @entity1 risk score classification of both normal and @entity6 individuals.

title: Non-HDL @entity2 shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL XXXX in a dyslipidemic population.

answer: @entity2


abstract: BACKGROUND: Posttransplant survival in heart transplant recipients has progressively improved during the past 2 decades. It is unknown, however, whether the major racial groups in the United States have benefited equally. METHODS AND RESULTS: We analyzed all primary heart transplant recipients aged >= 18 years in the United States from 1987 to 2008. We compared posttransplant survival in white, black, and Hispanic recipients in 5 successive eras (1987 to 1992, 1993 to 1996, 1997 to 2000, 2001 to 2004, 2005 to 2008). Early survival was defined as freedom from death or retransplantation during the first 6 months posttransplant. Longer-term, conditional survival was assessed in @entity0 who survived the first 6 months. There were 29 986 (81.6%) white, 4745 (12.9%) black, and 2017 (5.5%) Hispanic @entity0 in the study cohort. Black @entity0 were at increased risk of @entity1 or retransplant (hazard ratio [HR], 1.15; 95% CI, 1.05 to 1.26) in adjusted analysis. Early posttransplant survival improved (HR, 0.83; 95% CI, 0.80 to 0.87 for successive eras) equally in all 3 groups (black- @entity2 interaction, P=0.94; Hispanic- @entity2 interaction, P=0.40). Longer-term survival improved in white (HR, 0.95; 95% CI, 0.92 to 0.97 for successive eras) but not in black (HR, 1.04; 95% CI, 0.99 to 1.09) or Hispanic (HR, 1.02; 95% CI, 0.95 to 1.09) recipients, resulting in increased disparities in longer-term survival with time. CONCLUSIONS: Early posttransplant survival has improved equally in white, black, and Hispanic heart transplant recipients. Longer-term survival has improved in white but not in black or Hispanic recipients, resulting in a more marked disparity in outcomes in the current @entity2 . These disparities warrant further investigation and targeted interventions.

title: Improved survival in heart transplant recipients in the United States: racial differences in XXXX effect.

answer: @entity2


abstract: PURPOSE: @entity0 is a sight-threatening disease in which autoreactive T cells cross the blood-retinal barrier. Molecular mechanisms contributing to the @entity1 in this @entity0 are not well understood. In this study, the authors investigated the changes in the matrix metalloproteinase network in spontaneous @entity2 . METHODS: Matrix metalloproteinase (MMP) @entity4 , @entity5 , and @entity7 expression and @entity6 and @entity8 ( @entity8 ) expression were analyzed using Western blot quantification. Enzyme activities were examined with zymography. Expression patterns of network candidates were revealed with immunohistochemistry, comparing physiological appearance and changes in a spontaneous recurrent @entity2 model. RESULTS: @entity6 protein expression was found to be decreased in both the vitreous and the retina of a spontaneous model for @entity0 ( @entity3 recurrent @entity2 [ERU]), and @entity6 activity was significantly reduced in ERU vitreous. Functionally associated MMPs such as @entity4 , @entity7 , and @entity5 were found to show altered or shifted expression and activity. Although @entity4 decreased in ERU vitreous, @entity5 expression and activity were found to be increased. These changes were reflected by profound changes within uveitic target tissue, where @entity6 , @entity5 , and @entity7 decreased in expression, whereas @entity4 displayed a shifted expression pattern. @entity8 , a potential stabilizer of @entity5 , was found prominently expressed in @entity3 healthy retina and displayed notable changes in expression patterns accompanied by significant upregulation in autoimmune conditions. Invading cells expressed @entity5 and @entity8 . CONCLUSIONS: This study implicates a dysregulation or a change in functional protein-protein interactions in this @entity6 -associated protein network, together with altered expression of functionally related MMPs.

title: Changes in matrix metalloproteinase network in a spontaneous XXXX model.

answer: @entity0