abstract: Background. Lateropulsion, a @entity2 , delays recovery following @entity1 . The number of @entity1 may lead to differential recovery rates, depending on the intact systems available for recovery from lateropulsion. Objective. To study the impact of key postural control deficits on lateropulsion rate of recovery following @entity1 . Methods. Through retrospective analysis: 169 @entity0 with @entity1 in an in- @entity0 rehabilitation facility were divided into 3 groups: (1) motor deficits only; (2) motor and @entity4 or motor and proprioceptive deficits; and (3) motor, proprioceptive, and @entity4 . Kaplan-Meier survival analysis determined if time to recovery from lateropulsion (achieving a score of 0 or 1 on the Burke Lateropulsion Scale) differed by group. Results. Log rank tests showed that time to recovery from lateropulsion differed based on the number of deficits (group, P = .012). Post hoc analyses by lesion side showed that group differences only occurred in right @entity3 (P < .05) as compared with left @entity3 (P = .34). @entity0 recovered from lateropulsion during in- @entity0 rehabilitation if they had only motor deficits; those with all 3 postural control deficits showed the most protracted recovery. Conclusions. Rate of recovery from lateropulsion after @entity1 is dependent on the side of lesion, and number of key motor, proprioceptive, and/or @entity4 . The more postural control systems affected, the slower the recovery. Our data identify @entity0 likely to need protracted rehabilitation targeting key postural control deficits.

title: Time to Recovery From Lateropulsion Dependent on Key XXXX Deficits: A Retrospective Analysis.

answer: @entity1


abstract: OBJECTIVE: The aim of the study was to determine the epidemiological characteristics of @entity6 observed in neonates born in the Department of Gynaecology and Obstetrics, University Clinical Centre Tuzla, Bosnia and Herzegovina, admitted to Intensive care unit (NICU) or readmitted, because of suspected @entity0 , after discharge from the nursery. SUBJECTS AND METHODS: This study was carried out from July 1, 2012 to June 30, 2013. During this period 4136 neonates were born. All neonates admitted to the Intensive care unit with signs and symptoms of @entity0 , and neonates readmitted to the Intensive care unit, after discharge from the nursery for @entity1 work up were included in the study. RESULTS: Eighteen of 200 neonates (9%) admitted or readmitted to the NICU developed @entity4 . 61% cases were late onset @entity4 . The overall incidence was 4.4/1000 live births. The mortality rate was 11.1%. The mean age of symptom presentation was 8.7 days. The most common clinical features were: fever, @entity3 and @entity5 . Significant risk factors for acquiring @entity4 were: male gender, Caesarean delivery, stained amniotic fluid. Positive CSF finding were detected in 6/18 (33.3%) of cases. Gram-positive bacteria were more frequently responsible for confirmed @entity4 . In all neonates with @entity4 blood culture was examined and 5 (50%) yielded Gram-negative bacteria. CONCLUSION: The high rates of @entity4 with predominant late onset may suggest nosocomial origin. Measures to improve antenatal, intrapartum and delivery care and measures during NICU hospitalisation are necessary to lower the risk of @entity2 .

title: Neonatal XXXX : Results from a cross-sectional hospital based study.

answer: @entity6


abstract: OBJECT: Smoking is one of the leading causes of preventable morbidity and death in the U.S. and has been associated with perioperative complications. In this study, the authors examined the effects of smoking on perioperative outcomes and @entity5 rates following anterior cervical corpectomy. METHODS: All adult @entity0 from 2006 to 2011 who underwent anterior cervical corpectomy were identified. @entity0 were categorized into 3 groups: @entity0 who never smoked (nonsmokers), @entity0 who quit for at least 1 year (quitters), and @entity0 who continue to smoke (current smokers). Demographic, medical, and surgical covariates were collected. Multivariate analysis was used to define the relationship between smoking and @entity2 , 30-day complications, length of hospital stay, and @entity5 . RESULTS: A total of 160 @entity0 were included in the study. Of the 160 @entity0 , 49.4% were nonsmokers, 25.6% were quitters, and 25.0% were current smokers. The overall 30-day complication rate was 20.0%, and @entity5 occurred in 7.6% of @entity0 . Mean @entity2 was 368.3 ml and mean length of stay was 6.5 days. Current smoking status was significantly associated with higher complication rates (p < 0.001) and longer lengths of stay (p < 0.001); current smoking status remained an independent risk factor for both outcomes after multivariate logistic regression analysis. The complications that were experienced in current smokers were @entity3 (76.5%), and this proportion was significantly greater than in nonsmokers and quitters (p = 0.013). Current smoking status was also an independent risk factor for @entity5 at 1-year follow-up (p = 0.012). CONCLUSIONS: Smoking is independently associated with @entity4 (especially @entity1 ), longer lengths of stay, and higher rates of @entity5 in @entity0 undergoing anterior cervical corpectomy.

title: The effects of smoking on perioperative outcomes and XXXX following anterior cervical corpectomy: Clinical article.

answer: @entity5


abstract: BACKGROUND: It has been suggested that GastroPanel might be a useful tool for the diagnosis of chronic @entity3 (CAG) measuring four biomarkers in blood: basal gastrin-17 (G17), pepsinogen I and II ( @entity4 and @entity5 ), and @entity2 @entity2 antibodies. AIM: To determine the accuracy of GastroPanel for the diagnosis of CAG. METHODS: This was a prospective, blinded, multicenter study that included dyspeptic @entity0 . G17, @entity4 , and @entity5 were determined by enzyme immunoassays. Three antrum and two corpus biopsies were obtained for standard histological analysis and rapid urease test. Biopsies were analyzed by a single blinded expert pathologist. RESULTS: Ninety-one @entity0 were included (77% @entity0 , mean age 44 years, 51% @entity2 positive, 17% with CAG). G17 was reduced in @entity0 with antrum CAG (5.4 vs. 13.4   pmol/l; P<0.01) and increased in @entity0 with corpus CAG (11 vs. 24   pmol/l; P<0.05), but its accuracy was only acceptable in the case of corpus localization [area under the receiver operating characteristic curve (AUC), 74%]; @entity5 difference was almost statistically significant only when testing for corpus @entity1 (33 vs. 21    g/l; P=0.05; AUC=72%). The @entity4 and @entity4 / @entity5 ratio showed no significant differences (AUCs were all unacceptably low). @entity2 @entity2 antibody levels were higher in @entity2 -infected @entity0 (251 vs. 109 EIU, P=0.01; AUC=70). The accuracy of GastroPanel for the diagnosis of CAG was as follows: sensitivity 50%; specificity 80%; positive 25% and negative 92% predictive values; and positive 2.4 and negative 0.6 likelihood ratios. CONCLUSION: GastroPanel is not accurate enough for the diagnosis of CAG; thus, its systematic use in clinical practice cannot be recommended.

title: Accuracy of GastroPanel for the diagnosis of XXXX .

answer: @entity3


abstract: PURPOSE: This paper presents our 18  years of experience in treating ACTH secreting @entity2 ( @entity3 and @entity4 ) using the Leksell gamma knife (LGK) irradiation. METHODS: Twenty-six @entity0 with @entity3 were followed-up after LGK irradiation for 48-216  months (median 78  months). Seventeen @entity0 had undergone previous surgery, in nine @entity0 LGK irradiation was the primary therapy. Furthermore, 14 @entity0 with @entity4 were followed-up for 30-204  months (median 144  months). RESULTS: LGK treatment resulted in hormonal normalization in 80.7  % of @entity0 with @entity3 . Time to normalization was 6-54  months (median 30  months). The volume of the @entity2 decreased in 92.3  % (in 30.7  % disappeared completely). There was no recurrence of the disease. In all 14 @entity0 with @entity4 ACTH levels decreased (in two @entity0 fully normalized) their ACTH levels. When checked up 5-10  years after irradiation regrowth of the @entity2 was only detected in one @entity0 (9.1  %), in 27.3  % @entity2 volume remained unchanged, in 45.4  % @entity2 volume decreased and in 18.2  % @entity2 completely disappeared. @entity5 did not develop in any @entity0 where the critical dose to the pituitary and distal infundibulum was respected. CONCLUSION: LGK radiation represents an effective and well-tolerated option for the treatment of @entity0 with @entity3 after unsuccessful surgery and may be valuable even as a primary treatment in @entity0 who are not suitable for, or refuse, surgery. In the case of @entity4 it is possible to impede @entity1 growth and control the size of the @entity2 in almost all @entity0 .

title: Gamma knife radiosurgery for @entity3 and XXXX .

answer: @entity4


abstract: PURPOSE: This paper presents our 18  years of experience in treating ACTH secreting @entity2 ( @entity3 and @entity4 ) using the Leksell gamma knife (LGK) irradiation. METHODS: Twenty-six @entity0 with @entity3 were followed-up after LGK irradiation for 48-216  months (median 78  months). Seventeen @entity0 had undergone previous surgery, in nine @entity0 LGK irradiation was the primary therapy. Furthermore, 14 @entity0 with @entity4 were followed-up for 30-204  months (median 144  months). RESULTS: LGK treatment resulted in hormonal normalization in 80.7  % of @entity0 with @entity3 . Time to normalization was 6-54  months (median 30  months). The volume of the @entity2 decreased in 92.3  % (in 30.7  % disappeared completely). There was no recurrence of the disease. In all 14 @entity0 with @entity4 ACTH levels decreased (in two @entity0 fully normalized) their ACTH levels. When checked up 5-10  years after irradiation regrowth of the @entity2 was only detected in one @entity0 (9.1  %), in 27.3  % @entity2 volume remained unchanged, in 45.4  % @entity2 volume decreased and in 18.2  % @entity2 completely disappeared. @entity5 did not develop in any @entity0 where the critical dose to the pituitary and distal infundibulum was respected. CONCLUSION: LGK radiation represents an effective and well-tolerated option for the treatment of @entity0 with @entity3 after unsuccessful surgery and may be valuable even as a primary treatment in @entity0 who are not suitable for, or refuse, surgery. In the case of @entity4 it is possible to impede @entity1 growth and control the size of the @entity2 in almost all @entity0 .

title: Gamma knife radiosurgery for XXXX and @entity4 .

answer: @entity3


abstract: The housing tube material of the @entity4 Chaetopterus sp. exhibits thermal stability up to 250  C, similar to other biological materials such as mulberry @entity3 cocoons. Interestingly, however, dynamic mechanical thermal analysis conducted in both air and water elucidated the lack of a glass transition in the organic tube wall material. In fact, the viscoelastic properties of the anhydrous and undried tube were remarkably stable (i.e. constant and reversible) between -75  C and 200  C in air, and 5  C and 75  C in water, respectively. Moreover, it was found that hydration and associated-water plasticization were key to the rubber-like flexible properties of the tube; dehydration transformed the material behaviour to glass-like. The tube is made of bionanocomposite fibrils in highly oriented arrangement, which we argue favours the biomaterial to be highly crystalline or cross-linked, with extensive @entity1 and/or covalent bonds. Mechanical property characterization in the longitudinal and transverse directions ascertained that the tubes were not quasi-isotropic structures. In general, the higher stiffness and strength in the transverse direction implied that there were more nanofibrils orientated at    45   and    65   than at 0   to the @entity2 . The order of the mechanical properties of the soft-tough tubes was similar to @entity0 and even some viscid silks. The complex structure-property relations observed indicated that the worm has evolved to produce a tubular housing structure which can (i) function stably over a broad range of temperatures, (ii) endure mechanical stresses from specific planes/axes, and (iii) facilitate rapid growth or repair.

title: Housing tubes from the XXXX Chaetopterus sp.: biomaterials with exceptionally broad thermomechanical properties.

answer: @entity4


abstract: UNASSIGNED: The main objective of this study was to assess the diagnostic performance of a set of three Mucorales quantitative PCR assays in a retrospective multicentre study. @entity1 cases were recorded thanks to the French prospective surveillance programme (RESSIF network). The day of sampling of the first histological or mycological positive specimen was defined as day 0 (D0). Detection of circulating DNA was performed on frozen serum samples collected from D-30 to D30, using quantitative PCR assays targeting Rhizomucor, Lichtheimia, Mucor/Rhizopus. Forty-four @entity0 diagnosed with probable (n  =  19) or proven (n  =  25) @entity1 were included. Thirty-six of the 44 @entity0 (81%) had at least one PCR-positive serum. The first PCR-positive sample was observed 9  days (range 0-28  days) before diagnosis was made using mycological criteria and at least 2  days (range 0-24  days) before imaging. The identifications provided with the quantitative PCR assays were all concordant with culture and/or PCR-based identification of the causal species. Survival rate at D84 was significantly higher for @entity0 with an initially positive PCR that became negative after treatment initiation than for @entity0 whose PCR remained positive (48% and 4%, respectively; p <10(-6)). The median time for complete negativity of PCR was 7  days (range 3-19  days) after initiation of @entity2 treatment. Despite some limitations due to the retrospective design of the study, we showed that Mucorales quantitative PCR could not only confirm the @entity1 diagnosis when other mycological arguments were present but could also anticipate this diagnosis. Quantification of DNA loads may also be a useful adjunct to treatment monitoring.

title: Early diagnosis and monitoring of XXXX by detection of circulating DNA in serum: retrospective analysis of 44 cases collected through the French Surveillance Network of Invasive Fungal Infections (RESSIF).

answer: @entity1


abstract: BACKGROUND: This study was designed to assess whether cardiovascular magnetic resonance imaging (CMR) in @entity3 carriers (DMDc) may index any cell milieu elements of @entity2 and whether this cardiac phenotype may be related to genotype. The null hypothesis was that @entity1 , assessed by late @entity4 enhancement (LGE), might be similarly accounted for in DMDc and gender and age-matched controls. METHODS: Thirty DMDc @entity0 had CMR and genotyping with 37 gender and age-matched controls. Systolic and diastolic LV function was assessed by 2D-echocardiography. RESULTS: Absolute and percent LGE were higher in muscular symptomatic (sym) than asymptomatic (asy) DMDc (1.77        0.27 vs 0.76        0.17  ml; F =   19.6, p <   0.0001 and 1.86        0.26% vs 0.68        0.17%, F =   22.1, p <   0.0001, respectively). There was no correlation between LGE and age. LGE was seen most frequently in segments 5 and 6; segment 5 was involved in all asy-DMDc. Subepicardial LGE predominated, compared to the mid-myocardial one (11 out of 14 DMDc). LGE was absent in the subendocardium. No correlations were seen between genotyping (type of mutation, gene region and protein domain), confined to the exon's study, and cardiac phenotype. CONCLUSIONS: A typical myocardial LGE-pattern location (LV segments 5 and 6) was a common finding in DMDc. LGE was more frequently subepicardial plus midmyocardial in sym-DMDc, with normal LV systolic and diastolic function. No genotype-phenothype correlation was found.

title: Patterns of late XXXX enhancement in @entity3 carriers.

answer: @entity4


abstract: BACKGROUND: This study was designed to assess whether cardiovascular magnetic resonance imaging (CMR) in @entity3 carriers (DMDc) may index any cell milieu elements of @entity2 and whether this cardiac phenotype may be related to genotype. The null hypothesis was that @entity1 , assessed by late @entity4 enhancement (LGE), might be similarly accounted for in DMDc and gender and age-matched controls. METHODS: Thirty DMDc @entity0 had CMR and genotyping with 37 gender and age-matched controls. Systolic and diastolic LV function was assessed by 2D-echocardiography. RESULTS: Absolute and percent LGE were higher in muscular symptomatic (sym) than asymptomatic (asy) DMDc (1.77        0.27 vs 0.76        0.17  ml; F =   19.6, p <   0.0001 and 1.86        0.26% vs 0.68        0.17%, F =   22.1, p <   0.0001, respectively). There was no correlation between LGE and age. LGE was seen most frequently in segments 5 and 6; segment 5 was involved in all asy-DMDc. Subepicardial LGE predominated, compared to the mid-myocardial one (11 out of 14 DMDc). LGE was absent in the subendocardium. No correlations were seen between genotyping (type of mutation, gene region and protein domain), confined to the exon's study, and cardiac phenotype. CONCLUSIONS: A typical myocardial LGE-pattern location (LV segments 5 and 6) was a common finding in DMDc. LGE was more frequently subepicardial plus midmyocardial in sym-DMDc, with normal LV systolic and diastolic function. No genotype-phenothype correlation was found.

title: Patterns of late @entity4 enhancement in XXXX carriers.

answer: @entity3


abstract: PURPOSE: This in vitro study investigated the @entity0 resistance of endodontically treated premolars restored using @entity3 - or @entity2 -based composite along with or without fiber or nano-ionomer base. MATERIALS AND METHODS: Ninety-six intact maxillary premolars were randomly divided into eight groups (n = 12). G1 (negative control) was the intact teeth. In Groups 2-8, root canal treatment with mesio-occlusodistal preparation was performed. G2 (positive control) was kept unrestored. The other groups were restored using composite resin as follows: G3, @entity2 -based composite (Z250); G4, @entity2 composite (Z250) with @entity1 fiber; G5 and G6, @entity3 -based composite (Filtek P90) without and with the fiber, respectively; G7 and G8, @entity2 - and @entity3 -based composite with nano-ionomer base, respectively. After aging period and thermocycling for 1000 cycles, @entity0 strength was tested and @entity0 patterns were inspected. The results were analyzed using ANOVA and Tukey HSD tests (a=0.05). RESULTS: Mean @entity0 resistance for the eight groups (in Newton) were G1: 1200    169(a), G2: 360    93(b), G3: 632    196(c), G4: 692    195(c), G5: 917    159(d), G6: 1013    125(ad), G7: 959    148(d), G8: 947    105(d) (different superscript letters revealed significant difference among groups). Most of the @entity0 in all the groups were restorable, except Group 3. CONCLUSION: @entity3 -based composite revealed significantly higher strength of the restored premolars compared to that of @entity2 one. Fiber insertion demonstrated no additional effect on the strength of both composite restorations; however, it increased the prevalence of restorable @entity0 of @entity2 -based composite restored teeth. Using nano-ionomer base under @entity2 -based composite had a positive effect on @entity0 resistance and pattern. Only fiber-reinforced @entity3 composite restoration resulted in a strength similar to that of the intact teeth.

title: XXXX resistance of endodontically treated maxillary premolars restored by @entity3 -based composite with or without fiber or nano-ionomer.

answer: @entity0


abstract: PURPOSE: This in vitro study investigated the @entity0 resistance of endodontically treated premolars restored using @entity3 - or @entity2 -based composite along with or without fiber or nano-ionomer base. MATERIALS AND METHODS: Ninety-six intact maxillary premolars were randomly divided into eight groups (n = 12). G1 (negative control) was the intact teeth. In Groups 2-8, root canal treatment with mesio-occlusodistal preparation was performed. G2 (positive control) was kept unrestored. The other groups were restored using composite resin as follows: G3, @entity2 -based composite (Z250); G4, @entity2 composite (Z250) with @entity1 fiber; G5 and G6, @entity3 -based composite (Filtek P90) without and with the fiber, respectively; G7 and G8, @entity2 - and @entity3 -based composite with nano-ionomer base, respectively. After aging period and thermocycling for 1000 cycles, @entity0 strength was tested and @entity0 patterns were inspected. The results were analyzed using ANOVA and Tukey HSD tests (a=0.05). RESULTS: Mean @entity0 resistance for the eight groups (in Newton) were G1: 1200    169(a), G2: 360    93(b), G3: 632    196(c), G4: 692    195(c), G5: 917    159(d), G6: 1013    125(ad), G7: 959    148(d), G8: 947    105(d) (different superscript letters revealed significant difference among groups). Most of the @entity0 in all the groups were restorable, except Group 3. CONCLUSION: @entity3 -based composite revealed significantly higher strength of the restored premolars compared to that of @entity2 one. Fiber insertion demonstrated no additional effect on the strength of both composite restorations; however, it increased the prevalence of restorable @entity0 of @entity2 -based composite restored teeth. Using nano-ionomer base under @entity2 -based composite had a positive effect on @entity0 resistance and pattern. Only fiber-reinforced @entity3 composite restoration resulted in a strength similar to that of the intact teeth.

title: @entity0 resistance of endodontically treated maxillary premolars restored by XXXX -based composite with or without fiber or nano-ionomer.

answer: @entity3


abstract: Disruption of the endothelium leads to increased permeability, allowing extravasation of macromolecules and other solutes from blood vessels. @entity0 entry through a @entity0 -selective, store-operated @entity0 (SOC) channel, I soc, contributes to barrier disruption. An understanding of the mechanisms surrounding the regulation of I soc is far from complete. We show that the @entity0 /calmodulin-activated phosphatase calcineurin (CN) plays a role in regulation of SOC entry, possibly through the dephosphorylation of @entity4 ( @entity4 ). Phosphorylation has been implicated as a regulatory mechanism of activity for a number of canonical transient receptor potential (TRPC) and SOC channels, including I soc. Our results show that @entity4 phosphorylation increases in pulmonary artery endothelial cells (PAECs) upon activation of SOC entry. However, the phosphatases involved in @entity4 dephosphorylation are unknown. We found that a CN inhibitor ( @entity3 [ @entity3 ]) increases the phosphorylation pattern of @entity4 . Using a @entity1 -acetoxymethyl ester approach to measure cytosolic @entity0 in PAECs, we found that @entity3 decreases SOC entry following @entity2 treatment in PAECs. Luciferase assays indicate that @entity2 induces activation of CN activity and confirm inhibition of CN activity by @entity3 in PAECs. Also, I soc is significantly attenuated in whole-cell patch-clamp studies of PAECs treated with @entity3 . Finally, PAECs pretreated with @entity3 exhibit decreased interendothelial cell gap formation in response to @entity2 -induced SOC entry, as compared to control cells. Taken together, our data show that CN contributes to the phosphorylation status of @entity4 , which is important in regulation of endothelial SOC entry and I soc activity.

title: The serine-threonine phosphatase calcineurin is a regulator of endothelial store-operated XXXX entry.

answer: @entity0


abstract: The objective of this work was to establish a novel Mongolian gerbil (Meriones unguiculatus) @entity3 model and to investigate its susceptibility genetic basis. Two rodent (gerbil and @entity1 ) @entity3 models were induced by feeding a high fat/high- @entity2 (HF/HC) diet. There were significant increases of serum total @entity2 , @entity5 , low-density lipoprotein @entity2 (LDL-C), and high-density lipoprotein @entity2 (HDL-C) in gerbils within a 4-week modeling period. About 10-30% of >8-month-old individuals developed @entity3 spontaneously. The @entity8 ( @entity8 ) gene was cloned by merging a sequence of rapid amplification of cDNA ends (RACE) and nested polymerase chain reaction products. The results revealed an open reading frame of 948   bp, encoding a protein of 298 @entity4 . The gene without a 5'-UTR region in the first intron was highly homologous to @entity0 @entity6 and @entity1 @entity7 . The distribution of expression of the @entity8 gene in liver, brain, heart, lung, kidney, and adrenal gland was detected by an ABC immunohistochemical procedure. Three single nucleotide polymorphisms (SNPs; @entity9 , @entity10 , and @entity11 ) were first found using PCR-single-strand conformation polymorphism (PCR-SSCP) in a closed population containing 444 animals. Correlation analysis confirmed that new SNPs, age, and gender were associated significantly (P < 0.05) with @entity3 .

title: Primary genetic investigation of a XXXX model: molecular characteristics and variants of the @entity8 gene in Mongolian gerbil.

answer: @entity3


abstract: The objective of this work was to establish a novel Mongolian gerbil (Meriones unguiculatus) @entity3 model and to investigate its susceptibility genetic basis. Two rodent (gerbil and @entity1 ) @entity3 models were induced by feeding a high fat/high- @entity2 (HF/HC) diet. There were significant increases of serum total @entity2 , @entity5 , low-density lipoprotein @entity2 (LDL-C), and high-density lipoprotein @entity2 (HDL-C) in gerbils within a 4-week modeling period. About 10-30% of >8-month-old individuals developed @entity3 spontaneously. The @entity8 ( @entity8 ) gene was cloned by merging a sequence of rapid amplification of cDNA ends (RACE) and nested polymerase chain reaction products. The results revealed an open reading frame of 948   bp, encoding a protein of 298 @entity4 . The gene without a 5'-UTR region in the first intron was highly homologous to @entity0 @entity6 and @entity1 @entity7 . The distribution of expression of the @entity8 gene in liver, brain, heart, lung, kidney, and adrenal gland was detected by an ABC immunohistochemical procedure. Three single nucleotide polymorphisms (SNPs; @entity9 , @entity10 , and @entity11 ) were first found using PCR-single-strand conformation polymorphism (PCR-SSCP) in a closed population containing 444 animals. Correlation analysis confirmed that new SNPs, age, and gender were associated significantly (P < 0.05) with @entity3 .

title: Primary genetic investigation of a @entity3 model: molecular characteristics and variants of the XXXX gene in Mongolian gerbil.

answer: @entity8


abstract: BACKGROUND CONTEXT: Magnetically controlled growing rods (MCGRs) are used in the management of @entity2 ( @entity2 ). Each MCGR contains a telescopic actuator that serves as the distraction element when stimulated by an external remote controller (ERC), permitting non-invasive lengthening in the outpatient clinic. PURPOSE: This report highlights a subtle cause of MCGR failure. We present the first two reported cases of lengthening pin @entity1 in @entity0 with dual-MCGR constructs. STUDY DESIGN: We present two cases of @entity0 with @entity2 treated with dual-construct MAGEC (MAGnetic Expansion Control, @entity3 Technologies Inc, Aliso Viejo, CA, USA) MCGRs. METHODS: A 12-year-old @entity0 presented describing a "popping" sensation in his thoracic spine and resultant grating 36 months following MCGR insertion. RESULTS: A plain radiograph revealed a subtle @entity1 of the lengthening pin within the actuator of the right MCGR. Following identification of this case of implant failure, we reviewed the most recent radiographs of all nine of our @entity0 treated with this MCGR in our institution, resulting in the discovery of bilateral MCGR lengthening pin fractures in an otherwise asymptomatic 11-year-old @entity0 . CONCLUSIONS: Clinicians should have a high index of suspicion of structural implant failure when presented with histories similar to those reported in our first case, or following unsuccessful distraction of MCGRs. In such cases new radiographs should be taken, and all previous images should be reviewed for evidence of this phenomenon. Centers that document MCGR lengthening with ultrasound should obtain plain radiographs every 6 months to evaluate the structural integrity of the implant.

title: Actuator pin XXXX in magnetically controlled growing rods: two cases.

answer: @entity1


abstract: OBJECTIVE: To determine whether @entity0 expectancy plays a role in observed placebo and nocebo effects in 2 clinical trials. METHOD: Data were reanalyzed from 2 @entity3 -discontinuation studies conducted from March 1990 to September 1992 and from May 1997 to December 2002. The 673 outpatients included were aged 18-65 years with DSM-III-R @entity2 ( @entity2 ), responded to 12-week duration open treatment, and were randomized to continued @entity3 or placebo for an additional year. @entity0 in 1 of the included studies received a fixed dose of @entity3 20 mg daily, while the second study utilized flexible @entity3 doses up to 60 mg daily. Mixed @entity1 whether the possible randomization to placebo at 12 weeks resulted in significant @entity2 worsening across treatments. Correlations were computed between early symptom change (weeks 1-3 of open treatment) and postrandomization symptom change (weeks 13-16 following randomization). RESULTS: @entity0 continuing to receive @entity3 and those switched to placebo had significantly higher mean @entity2 ( @entity2 ) scores immediately postrandomization compared to the final weeks of open treatment (P < .001 for both @entity3 - and placebo-treated @entity0 ). In both studies, early @entity2 change was significantly correlated with postrandomization @entity2 change for @entity0 receiving @entity3 (r = -0.46, P < .001) as well as placebo (r = -0.48, P < .001). CONCLUSIONS: The possibility of receiving placebo following 12 weeks of open @entity3 was associated with significant symptom worsening in 2 large @entity3 discontinuation studies. Worsening @entity2 scores following randomization were significantly associated with the degree of improvement @entity0 experienced during weeks 1-3 of open treatment. These results suggest that treatment changes influence @entity0 ' expectations of improvement, which, in turn, affect their @entity2 symptoms.

title: The role of XXXX expectancy in placebo and nocebo effects in antidepressant trials.

answer: @entity0


abstract: The purpose of the present study was to evaluate whether diffusion-weighted imaging (DWI) can be used to assess @entity4 ( @entity4 ) @entity5 (TACE). A total of 41 consecutive @entity0 were treated according to chemoembolization protocols. The follow-up was performed between six and eight weeks post-chemoembolization by multidetector computed tomography [or enhanced magnetic resonance imaging (MRI)] and DW-MRI on the same day. The presence of any @entity3 and the extent of @entity1 @entity2 were evaluated according to the European Association for the Study of the Liver. The apparent diffusion coefficient (ADC) values of the entire area of the treated mass and the vital and @entity1 tissues were recorded. Correlation coefficients were also calculated to compare the percentage of @entity2 with ADC values. The mean ADC values of the @entity1 tissues were 2.22  0.31 10(-3) mm(2)/sec and 1.42  0.25 10(-3) mm(2)/sec, respectively (Mann-Whitney U test, P<0.001). The results from the receiver operating characteristic analysis showed that the threshold ADC value was 1.84 10(-3) mm(2)/sec with 92.3% sensitivity and 100% specificity for identifying the @entity1 tissues. A significant linear regression correlation was identified between the ADC value of the entire area of the treated mass and the extent of @entity1 @entity2 (r=0.58; P<0.001). In conclusion, DWI can be used to assess @entity4 viability following TACE.

title: Utility of diffusion-weighted imaging to assess XXXX @entity5 .

answer: @entity4


abstract: The purpose of the present study was to evaluate whether diffusion-weighted imaging (DWI) can be used to assess @entity4 ( @entity4 ) @entity5 (TACE). A total of 41 consecutive @entity0 were treated according to chemoembolization protocols. The follow-up was performed between six and eight weeks post-chemoembolization by multidetector computed tomography [or enhanced magnetic resonance imaging (MRI)] and DW-MRI on the same day. The presence of any @entity3 and the extent of @entity1 @entity2 were evaluated according to the European Association for the Study of the Liver. The apparent diffusion coefficient (ADC) values of the entire area of the treated mass and the vital and @entity1 tissues were recorded. Correlation coefficients were also calculated to compare the percentage of @entity2 with ADC values. The mean ADC values of the @entity1 tissues were 2.22  0.31 10(-3) mm(2)/sec and 1.42  0.25 10(-3) mm(2)/sec, respectively (Mann-Whitney U test, P<0.001). The results from the receiver operating characteristic analysis showed that the threshold ADC value was 1.84 10(-3) mm(2)/sec with 92.3% sensitivity and 100% specificity for identifying the @entity1 tissues. A significant linear regression correlation was identified between the ADC value of the entire area of the treated mass and the extent of @entity1 @entity2 (r=0.58; P<0.001). In conclusion, DWI can be used to assess @entity4 viability following TACE.

title: Utility of diffusion-weighted imaging to assess @entity4 XXXX .

answer: @entity5


abstract: @entity14 or @entity2 has been defined by the @entity12 as a behavioral addiction. To date, its pathophysiology is not completely understood and there is no FDA-approved treatment for @entity2 . @entity7 is the principal excitatory neurotransmitter in the nervous system and it has been recently involved in the pathophysiology of @entity3 . In this paper, we review the current literature on a class of drugs that act as modulating @entity7 system in PG. A total of 19 studies have been included, according to inclusion and exclusion criteria. Clinical trial and case series using glutamatergic drugs ( @entity4 , @entity10 , @entity13 , @entity5 , @entity15 , @entity6 , @entity8 , @entity11 , and @entity9 ) will be presented to elucidate the effectiveness on gambling behaviors and on the related clinical dimensions (craving, withdrawal, and @entity1 ) in PG @entity0 . The results have been discussed to gain more insight in the pathophysiology and treatment of PG. In conclusion, manipulation of glutamatergic neurotransmission appears to be promising in developing improved therapeutic agents for the treatment of @entity2 . Further studies are required. Finally, we propose future directions and challenges in this research area.

title: Targeting the glutamatergic system to treat XXXX : current evidence and future perspectives.

answer: @entity14


abstract: In this study, we tested the hypothesis that the alternating of hypoperfusion and full reperfusion (hypoperfusion postconditioning) could improve neuroprotection on @entity2 in @entity0 and explored the role of TAp63 and    Np63 in this process. Eighty male @entity0 were randomly divided into 4 groups: the sham group, the cerebral ischemic/reperfusion group (I/R), the hypoperfusion group 1 ( @entity3 ), and the hypoperfusion group 2 ( @entity4 ). @entity2 was established by clamping the bilateral common carotid artery with @entity1 for 20 minutes. For the @entity0 in the @entity3 group, the blood pressure was maintained to 80 to 90 mm Hg in clamping bilateral common carotid artery minutes and then unclamped. For the @entity0 in the @entity4 group, the clamping was performed at one side of the common carotid artery and one half of the other side of common carotid artery. Neurologic behavior scores in the I/R, @entity3 , and @entity4 groups decreased significantly after @entity2 , and scores in the @entity4 group were significantly higher than those in the I/R group (P < 0.05). Neuronal densities in the @entity3 and @entity4 groups were significantly higher than that in the I/R group (P < 0.05). Neuronal apoptosis in the @entity3 and @entity4 groups was significantly lower than that in the I/R group (P < 0.05). TAp63 and S100b concentration decreased, and    Np63 increased significantly in the @entity3 and @entity4 groups as compared with the I/R group (P < 0.05). No significant difference in these parameters between the @entity3 and @entity4 groups (P > 0.05). Alternating of hypoperfusion and normal perfusion postconditioning had neuroprotection function on @entity2 in the @entity0 . This could relate with decreasing expression of TAp63 and increasing expression of    Np63 in hippocampal region of the first area in the hippocampal circuit to inhibit neuronal apoptosis.

title: The experiment research of neuroprotection of hypoperfusion postconditioning on XXXX .

answer: @entity2


abstract: INTRODUCTION AND AIM: Implementing integrated systems for emergency care of @entity0 with acute @entity3 helps reduce morbidity and mortality. We describe the process of organizing and implementing a regional system to cover around 3.7 million @entity0 and its main initial results. METHODS: We performed a descriptive analysis of the implementation process and a retrospective analysis of the following parameters: number of @entity0 prenotified by the pre-hospital system; number of times thrombolysis was performed; door-to-needle time; and functional assessment three months after @entity1 . RESULTS: The implementation process started in November 2005 and ended in December 2009, and included 11 health centers. There were 3574 prenotifications from the prehospital system. Thrombolysis was performed in 1142 @entity0 . The percentage of @entity0 receiving thrombolysis rose during the study period, with a maximum of 16%. Median door-to-needle time was 62 min in 2009. Functional recovery three months after @entity1 was total or near total in 50% of @entity0 . CONCLUSIONS: The regional system implemented for emergency care of @entity0 with acute @entity3 has led to health gains, with progressive improvements in @entity0 ' access to thrombolysis, and to greater equity in the health care system, thus helping to reduce mortality from @entity2 in Portugal. Our results, which are comparable with those of international studies, support the strategy adopted for implementation of this system.

title: [Implementation of a regional system for the emergency care of acute XXXX : Initial results].

answer: @entity3


abstract: BACKGROUND: Data comparing systemic exposure and systemic @entity1 ( @entity1 ) suppression of ranibizumab, bevacizumab and aflibercept following intravitreal injection are lacking. METHODS: Fifty-six @entity0 with wet age-related @entity2 received intravitreal ranibizumab (0.5   mg), bevacizumab (1.25   mg), or aflibercept (2.0   mg). Serum pharmacokinetics and plasma free @entity1 were evaluated after the first and third injections. RESULTS: Following the first dose, systemic exposure to aflibercept was 5-, 37-, and 9-fold higher than ranibizumab, whereas, bevacizumab was 9-, 310-, and 35-fold higher than ranibizumab, based on geometric mean ratio of peak and trough concentrations and area under the curve, respectively. The third dose showed accumulation of bevacizumab and aflibercept but not ranibizumab. Aflibercept substantially suppressed plasma free @entity1 , with mean levels below lower limit of quantitation (10   pg/mL) as early as 3   h postdose until >= 7   days postdose. Mean free (unbound) @entity1 levels with ranibizumab were largely unchanged, with mean trough level of 14.4   pg/mL compared with baseline of 17   pg/mL. CONCLUSIONS: There are notable differences in systemic pharmacokinetics and pharmacodynamics among anti- @entity1 treatments after intravitreal administration. All three agents rapidly moved into the bloodstream, but ranibizumab very quickly cleared, whereas bevacizumab and aflibercept demonstrated greater systemic exposure and produced a marked reduction in plasma free @entity1 . TRIAL REGISTRATION NUMBER: NCT02118831.

title: Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in XXXX with neovascular AMD.

answer: @entity0


abstract: @entity2 ) is an important immunoregulatory cytokine that has a central role against viral and @entity5 . In this study, the cDNA encoding 141 @entity4 of mature @entity2 from @entity1 splenocytes was cloned in a prokaryotic expression vector pQE 30. Optimization of expression conditions resulted in high @entity2 protein. Western blot showed that recombinant @entity2 was specifically recognized by its counterpart anti-mouse @entity2 antibodies. In vitro dose-dependent studies, with A549 and HeLa cell lines, showed that cloned @entity2 was safe and had no effect on cell proliferation. The protein prediction and analysis using SOPMA program, revealed that @entity2 had 80 a-helices, 8 b-turns jointed by 9 extended strands and 44 random coils. A total of four major clusters were observed with @entity1 @entity2 sharing 39 % homology with @entity0 @entity2 . Pair-wise alignment studies with @entity0 revealed 26 % identity and 43.3 % similarity. The recovery of bioactive proteins from inclusion bodies (IBs) is a complex process and various protocols have been developed. We report here a simple, robust and inexpensive purification approach for obtaining recombinant @entity2 protein expressed as IBs in @entity3 .

title: Optimization of conditions for expression of recombinant interferon-y in XXXX .

answer: @entity3


abstract: SUMMARY: Although @entity3 is not considered among the classic causes of secondary @entity2 , the present meta-analysis provides strong evidence that @entity0 with @entity3 have a significant reduction in both lumbar spine and femoral @entity1 , which appears to begin in childhood. INTRODUCTION: @entity3 is not considered among the classic causes of secondary @entity2 . The aim of this study was to systematically review the literature for case-control trials that have studied bone mass in males with @entity3 and to meta-analyze the best evidence available. METHODS: Electronic databases MEDLINE, EMBASE and CENTRAL were systematically searched for case-control trials that have studied bone mass in @entity0 or @entity0 with @entity3 . Standardized mean difference (SMD) for @entity1 ( @entity1 ) in the lumbar spine was the main study outcome and @entity1 the secondary ones. @entity0 and control characteristics, such as age, body mass index (BMI), level of physical activity and @entity4 were recorded as possible predictors of the main outcome. RESULTS: Thirteen studies were included in the systematic review and ten in the main outcome meta-analysis. @entity0 with @entity3 demonstrated reduced lumbar spine [random effects SMD [95 % confidence interval (CI)] = -0.56 (-0.84, -0.28), between-study heterogeneity (I (2))   =   51 %] and femoral neck @entity1 [random effects SMD (95 % CI) = -0.82 (-1.21, -0.44), I (2)   =   63 %] compared with controls, which indicated a large and clinically significant association. Similar results were obtained for @entity0 [random effects SMD (95 % CI) = -0.92 (-1.77, -0.07), I (2)   =   92 %]. No evidence of publication bias was detected. There was no evidence that age, BMI, level of physical activity or presence of @entity4 predicted lumbar spine @entity1 . CONCLUSIONS: This meta-analysis shows that @entity0 with @entity3 present a significant reduction in both lumbar spine and hip @entity1 , which appears to begin in childhood.

title: Bone mineral density in @entity0 and @entity0 with XXXX and B: a systematic review and meta-analysis.

answer: @entity3


abstract: SUMMARY: Although @entity3 is not considered among the classic causes of secondary @entity2 , the present meta-analysis provides strong evidence that @entity0 with @entity3 have a significant reduction in both lumbar spine and femoral @entity1 , which appears to begin in childhood. INTRODUCTION: @entity3 is not considered among the classic causes of secondary @entity2 . The aim of this study was to systematically review the literature for case-control trials that have studied bone mass in males with @entity3 and to meta-analyze the best evidence available. METHODS: Electronic databases MEDLINE, EMBASE and CENTRAL were systematically searched for case-control trials that have studied bone mass in @entity0 or @entity0 with @entity3 . Standardized mean difference (SMD) for @entity1 ( @entity1 ) in the lumbar spine was the main study outcome and @entity1 the secondary ones. @entity0 and control characteristics, such as age, body mass index (BMI), level of physical activity and @entity4 were recorded as possible predictors of the main outcome. RESULTS: Thirteen studies were included in the systematic review and ten in the main outcome meta-analysis. @entity0 with @entity3 demonstrated reduced lumbar spine [random effects SMD [95 % confidence interval (CI)] = -0.56 (-0.84, -0.28), between-study heterogeneity (I (2))   =   51 %] and femoral neck @entity1 [random effects SMD (95 % CI) = -0.82 (-1.21, -0.44), I (2)   =   63 %] compared with controls, which indicated a large and clinically significant association. Similar results were obtained for @entity0 [random effects SMD (95 % CI) = -0.92 (-1.77, -0.07), I (2)   =   92 %]. No evidence of publication bias was detected. There was no evidence that age, BMI, level of physical activity or presence of @entity4 predicted lumbar spine @entity1 . CONCLUSIONS: This meta-analysis shows that @entity0 with @entity3 present a significant reduction in both lumbar spine and hip @entity1 , which appears to begin in childhood.

title: Bone mineral density in XXXX and @entity0 with @entity3 and B: a systematic review and meta-analysis.

answer: @entity0


abstract: SUMMARY: Although @entity3 is not considered among the classic causes of secondary @entity2 , the present meta-analysis provides strong evidence that @entity0 with @entity3 have a significant reduction in both lumbar spine and femoral @entity1 , which appears to begin in childhood. INTRODUCTION: @entity3 is not considered among the classic causes of secondary @entity2 . The aim of this study was to systematically review the literature for case-control trials that have studied bone mass in males with @entity3 and to meta-analyze the best evidence available. METHODS: Electronic databases MEDLINE, EMBASE and CENTRAL were systematically searched for case-control trials that have studied bone mass in @entity0 or @entity0 with @entity3 . Standardized mean difference (SMD) for @entity1 ( @entity1 ) in the lumbar spine was the main study outcome and @entity1 the secondary ones. @entity0 and control characteristics, such as age, body mass index (BMI), level of physical activity and @entity4 were recorded as possible predictors of the main outcome. RESULTS: Thirteen studies were included in the systematic review and ten in the main outcome meta-analysis. @entity0 with @entity3 demonstrated reduced lumbar spine [random effects SMD [95 % confidence interval (CI)] = -0.56 (-0.84, -0.28), between-study heterogeneity (I (2))   =   51 %] and femoral neck @entity1 [random effects SMD (95 % CI) = -0.82 (-1.21, -0.44), I (2)   =   63 %] compared with controls, which indicated a large and clinically significant association. Similar results were obtained for @entity0 [random effects SMD (95 % CI) = -0.92 (-1.77, -0.07), I (2)   =   92 %]. No evidence of publication bias was detected. There was no evidence that age, BMI, level of physical activity or presence of @entity4 predicted lumbar spine @entity1 . CONCLUSIONS: This meta-analysis shows that @entity0 with @entity3 present a significant reduction in both lumbar spine and hip @entity1 , which appears to begin in childhood.

title: Bone mineral density in @entity0 and XXXX with @entity3 and B: a systematic review and meta-analysis.

answer: @entity0


abstract: INTRODUCTION: Dietary supplements are widely used but are unregulated by the US Food and Drug Administration. Presented here is a case of severe @entity2 possibly associated with a dietary supplement, which demonstrates the need for improved @entity0 -physician communication regarding the possible risks and lack of regulation of dietary supplements. METHODS: A 26-year-old @entity0 presented with 3 days of @entity3 . The @entity0 had been taking a dietary supplement called N.O.-Xplode for 3 months. Initial laboratory tests revealed a @entity4 value of 9.45 mg/dL. Extensive laboratory analysis and imaging revealed no underlying cause of his @entity1 . Renal biopsy showed @entity5 with normal glomeruli. After discontinuing N.O.-Xplode, renal function returned to normal within 1 week. CONCLUSIONS: This case demonstrates the need for improved @entity0 -physician communication about dietary supplements. The @entity0 had not consulted a physician before initiating use; the amount of each ingredient contained in the dietary supplement is unavailable; and there are no available data regarding safety or efficacy. It is critical that physicians are able and open to counseling @entity0 on the inherent risks associated with dietary supplements, including their lack of regulation by the Food and Drug Administration, unknown efficacy, and possible serious adverse outcomes.

title: XXXX in a soldier taking N.O.-Xplode.

answer: @entity2


abstract: BACKGROUND: A new Japanese histologic classification (JHC) of immunoglobulin A @entity1 (IgAN) for prediction of long-term prognosis was proposed in 2013. The goal of this study was to validate the JHC system in a Japanese single-center cohort. METHODS: A retrospective study was conducted in 198 Japanese adult @entity0 with IgAN. Clinical findings including blood pressure, urinary protein, estimated glomerular filtration rate (eGFR), and outcomes were evaluated in these @entity0 . The @entity1 percentage score (GLPS) [number of glomeruli with cellular crescents, fibrocellular crescents, @entity3 , segmental @entity3 , or fibrous crescents/number of total obtained glomeruli     100 (%)] was assessed in each @entity0 and categorized into histologic grades (HGs) of @entity5 (<25  %), @entity4 (25-49  %), and @entity6 (>= 50  %). Associations of GLPS (HG) with disease progression (50  % eGFR decline or @entity2 requiring dialysis) within 10  years after biopsy and the rate of annual eGFR decline were examined. RESULTS: During a median follow-up period of 12.0  years after biopsy, disease progression occurred in 12.8  % (12/94) of @entity5 @entity0 , 32.3  % (21/65) of @entity4 @entity0 , and 46.2  % (18/39) of @entity6 @entity0 . The risk of disease progression was significantly higher in the @entity4 and @entity6 groups than in the @entity5 group (odds ratios: 3.3 and 5.9 vs. 1). A higher GLPS was significantly associated with a higher risk of disease progression and a greater annual eGFR decline. CONCLUSION: The newly proposed JHC system 2013 based on GLPS (HG) was well correlated with long-term prognosis in our cohort of Japanese adult @entity0 with IgAN.

title: Validation of the Japanese histologic classification 2013 of immunoglobulin A XXXX for prediction of long-term prognosis in a Japanese single-center cohort.

answer: @entity1


abstract: CONTEXT: The occurrence of severe @entity3 after laparoscopic total fundoplication is currently an important factor associated with loss of quality of life in @entity0 undergoing this modality of treatment for @entity2 . OBJECTIVES: Compare the incidence and evaluate the causes of severe @entity1 in @entity0 undergoing laparoscopic total fundoplication (LTF) without short gastric vessels division, using the anterior gastric wall (Rossetti LTF) or anterior and posterior gastric walls (Nissen LTF). METHODS: Analysis of the data of 289 @entity0 submitted to LTF without short gastric vessels division from January 2004 to January 2012, with a minimum follow-up of 6 months. @entity0 were divided in Group 1 (Rossetti LTF - n = 160) and Group 2 (Nissen LTF - n = 129). RESULTS: The overall incidence of severe @entity1 was 3.11% (4.37% in group 1 and 1.55% in group 2; P = 0.169). The need for surgical treatment of @entity3 was 2.5% in group 1 and 0.78% in group 2 (= 0.264). Distortions of the fundoplication were identified as possible causes of the @entity3 in all @entity0 taken to redo fundoplication after Rossetti LTF. No wrap distortion was seen in redo fundoplication after Nissen LTF. CONCLUSIONS: The overall incidence of severe @entity1 did not differ on the reported techniques. Only Rossetti LTF was associated with structural distortion of the fundoplication that could justify the @entity3 .

title: XXXX after laparoscopic total fundoplication: anterior or posterior gastric wall fundoplication?

answer: @entity3


abstract: BACKGROUND: Care for elderly @entity0 with @entity1 can pose dilemmas, because radical total mesorectal excision surgery comes with high morbidity and mortality rates. OBJECTIVE: The purpose of this study was to analyze the treatment of @entity0 with @entity1 , comparing treatment choices, guideline adherence, and outcomes for elderly @entity0 (>= 75 years) with younger @entity0 (<75 years). DESIGN: @entity0 data were retrieved from the hospital pathology database and from the hospital prospective colorectal surgery database for surgically treated @entity0 . Records were reviewed for nonadherence to treatment guidelines. Delivered treatment modalities for @entity0 with stage I to @entity1 were compared with treatment advised by national guidelines, and reasons stated by the treating physician for nonadherence to guidelines were subsequently collected. SETTINGS: This study was performed at a high-volume teaching hospital. @entity0 : @entity0 included were those with newly diagnosed @entity1 ( <=10 cm from the anal verge). MAIN OUTCOME MEASURES: Treatment decisions, guideline adherence, and outcome of surgical treatment were the main outcome parameters. RESULTS: Of 218 included @entity0 , 75 (34%) were aged >= 75 years. Guideline adherence for all of the treatment modalities in stage I to @entity1 was significantly lower in elderly @entity0 (62% versus 87% for aged <75 years; p < 0.001), and age was the primary reason mentioned for withholding treatment. Palliative anticancer treatment for stage IV disease was also initiated significantly less frequently in elderly @entity0 (60% versus 97%; p = 0.002). Overall rates of treatment complications were similar for both @entity0 groups (p = 0.71), but the impact of complications on survival was much greater for elderly @entity0 (p = 0.002). LIMITATIONS: Data on outcome of other treatment modalities, such as chemotherapy and radiotherapy, are lacking. CONCLUSIONS: Guideline adherence for all of the treatment modalities in stage I to @entity1 declines significantly with increasing age. Future research should focus on strategies of treatment tailored to @entity0 health status rather than chronological age.

title: Age-related guideline adherence and outcome in XXXX .

answer: @entity1


abstract: BACKGROUND: A @entity9 is the collection of pancreatic secretions surrounded by fibrous tissue caused by @entity6 that affects the pancreatic duct. Clinical presentation is variable. Management includes percutaneous, endoscopic or surgical drainage and resection. MATERIAL AND METHODS: Review of a cohort of @entity0 with @entity9 in a third level hospital. An analysis was performed on the demographic data, aetiology, clinical presentation, radiological and laboratory findings, type of surgical procedure, complications, recurrence and mortality. The statistical analysis was performed using Chi squared and Student t tests, with a p<0.05. RESULTS: A total of 139 @entity0 were included, of whom 58% were @entity0 and 42% were @entity0 , with median age of 44.5 years. @entity8 was the most common aetiology, present in 74 @entity0 (53%). The main complaint was @entity3 in 73% of @entity0 . Median size was 18cm (range 7-29) and the most frequent location was body and tail of the pancreas. Internal surgical drainage was selected in 111 (80%) @entity0 , of whom 96 were cystojejunostomy, 20 (14%) had external surgical drainage, and 8 (6%) resection. Complications were, pancreatic @entity2 (12%), @entity5 (4%), @entity1 (4%), and other @entity4 (4%). Complication rate was higher if the cause was chronic @entity7 or if the management was external surgical drainage. Recurrence rate was 6%, and a mortality rate of 1%. CONCLUSION: Surgical management is a viable option for the management of @entity9 with a low complication and recurrence rate.

title: [Surgical treatment of XXXX ].

answer: @entity9


abstract: BACKGROUND: Catheter ablation for AF is an effective treatment for @entity0 with AF and systolic LV dysfunction; however, the clinical outcome is variable. We evaluated the impact of @entity1 etiology on long-term outcomes post-catheter ablation. METHODS: @entity0 undergoing AF ablation across 3 centers (2 Australian, 1 UK) from 2002 to 2014, with LVEF<45% were evaluated. @entity0 were stratified into those with known @entity2 as a cause of @entity1 (KHD), and those with @entity3 ( @entity3 ). RESULTS: One hundred and one @entity0 ( @entity3 = 77, KHD = 24) with AF and LVEF <45% underwent AF ablation. The KHD group (ischemic @entity4 in 67%) were older (61    7 vs. 55    11 years, P = 0.005), with a higher CHADS2 score (2.0    0.8 vs. 1.6    0.7, P = 0.016), but otherwise well matched. After mean follow-up of 36    23 months, AF control was greater in the @entity3 group (82% vs. 50% in KHD, P < 0.001). On multivariate analysis @entity3 was associated with long-term AF control (P = 0.033). The @entity3 group had less functional impairment at follow-up (NYHA class 1.5    0.7 vs. 2.0    0.8, P = 0.005) and improved LVEF (50    11% vs. 38    10%, P < 0.001). Super responders (EF improvement >15%) were overwhelmingly in the @entity3 group (94% vs. 6%, P < 0.001) with greater AF control (89% vs. 61%, P < 0.001). All-cause mortality was significantly higher in the KHD group (17% vs. 1.3%, P = 0.002). CONCLUSION: @entity3 was associated with greater AF control, and improvement in symptoms and LVEF compared to @entity0 with KHD post-AF ablation. AF is an important reversible cause of HF in @entity0 with an unexplained CM and catheter ablation an effective treatment option.

title: The Impact of Known XXXX on Long-Term Outcomes of Catheter Ablation in @entity0 with Atrial Fibrillation and Left Ventricular Systolic Dysfunction: A Multicenter International Study.

answer: @entity2


abstract: BACKGROUND: Catheter ablation for AF is an effective treatment for @entity0 with AF and systolic LV dysfunction; however, the clinical outcome is variable. We evaluated the impact of @entity1 etiology on long-term outcomes post-catheter ablation. METHODS: @entity0 undergoing AF ablation across 3 centers (2 Australian, 1 UK) from 2002 to 2014, with LVEF<45% were evaluated. @entity0 were stratified into those with known @entity2 as a cause of @entity1 (KHD), and those with @entity3 ( @entity3 ). RESULTS: One hundred and one @entity0 ( @entity3 = 77, KHD = 24) with AF and LVEF <45% underwent AF ablation. The KHD group (ischemic @entity4 in 67%) were older (61    7 vs. 55    11 years, P = 0.005), with a higher CHADS2 score (2.0    0.8 vs. 1.6    0.7, P = 0.016), but otherwise well matched. After mean follow-up of 36    23 months, AF control was greater in the @entity3 group (82% vs. 50% in KHD, P < 0.001). On multivariate analysis @entity3 was associated with long-term AF control (P = 0.033). The @entity3 group had less functional impairment at follow-up (NYHA class 1.5    0.7 vs. 2.0    0.8, P = 0.005) and improved LVEF (50    11% vs. 38    10%, P < 0.001). Super responders (EF improvement >15%) were overwhelmingly in the @entity3 group (94% vs. 6%, P < 0.001) with greater AF control (89% vs. 61%, P < 0.001). All-cause mortality was significantly higher in the KHD group (17% vs. 1.3%, P = 0.002). CONCLUSION: @entity3 was associated with greater AF control, and improvement in symptoms and LVEF compared to @entity0 with KHD post-AF ablation. AF is an important reversible cause of HF in @entity0 with an unexplained CM and catheter ablation an effective treatment option.

title: The Impact of Known @entity2 on Long-Term Outcomes of Catheter Ablation in XXXX with Atrial Fibrillation and Left Ventricular Systolic Dysfunction: A Multicenter International Study.

answer: @entity0


abstract: In the present study we explored the role of b-catenin in mediating @entity1 retina regeneration. The @entity1 can regenerate its retina by activating stem/progenitor cells present in the @entity2 ( @entity2 ) of the eye or via transdifferentiation of the @entity0 ( @entity0 ). Both modes require @entity4 ( @entity4 ). We observed, by immunohistochemistry, dynamic changes of nuclear b-catenin in the @entity2 and @entity0 after injury (retinectomy). b-Catenin nuclear accumulation was transiently lost in cells of the @entity2 in response to injury alone, while the loss of nuclear b-catenin was maintained as long as @entity4 was present. However, nuclear b-catenin positive cells remained in the @entity0 in response to injury and were BrdU-/p27+, suggesting that nuclear b-catenin prevents those cells from entering the cell cycle. If @entity4 is present, the @entity0 undergoes dedifferentiation and proliferation concomitant with loss of nuclear b-catenin. Moreover, retinectomy followed by disruption of active b-catenin by using a signaling inhibitor ( @entity3 ) or over-expressing a dominant negative form of @entity5 induces regeneration from both the @entity2 and @entity0 in the absence of @entity4 . Our results imply that b-catenin protects cells of the @entity2 and @entity0 from entering the cell cycle in the developing eye, and specifically for the @entity0 during injury. Thus inactivation of b-catenin is a pre-requisite for @entity1 retina regeneration.

title: b-Catenin inactivation is a pre-requisite for XXXX retina regeneration.

answer: @entity1


abstract: OBJECTIVES: An estimated 25% of type two @entity1 ( @entity7 ) @entity0 in the United States are undiagnosed due to inadequate screening, because it is prohibitive to administer laboratory tests to everyone. We assess whether @entity3 ( @entity3 ) phenotyping could improve @entity7 screening compared to conventional models, even when records are incomplete and not recorded systematically across @entity0 and practice locations, as is typically seen in practice. METHODS: In this cross-sectional, retrospective study, @entity3 data from 9948 US @entity0 were used to develop a pre-screening tool to predict current @entity7 , using multivariate logistic regression and a random-forests probabilistic model for out-of-sample validation. We compared (1) a full @entity3 model containing commonly prescribed medications, diagnoses, and conventional predictors, (2) a restricted @entity3 DX model which excluded medications, and (3) a conventional model containing basic predictors and their interactions (BMI, age, sex, smoking status, @entity2 ). RESULTS: Using a @entity0 's full @entity3 or restricted @entity3 was superior to using basic covariates alone for detecting individuals with @entity1 ( @entity5 (2) test, p<0.001). @entity6 and @entity4 were associated negatively with @entity7 , while sexual and @entity8 were associated positively. Adding @entity3 phenotypes improved classification; the AUC for the full @entity3 Model, @entity3 DX model, and conventional model using logistic regression, were 84.9%, 83.2%, and 75.0% respectively. For random forest out-of-sample prediction, accuracy also was improved when using @entity3 phenotypes; the AUC values were 81.3%, 79.6%, and 74.8%, respectively. Improved AUCs reflect better performance for most thresholds that balance sensitivity and specificity. CONCLUSIONS: @entity3 phenotyping resulted in markedly superior detection of @entity7 , even in the face of missing and unsystematically recorded data, based on the ROC curves. @entity3 phenotypes could more efficiently identify which @entity0 do require, and don't require, further laboratory screening. When applied to the current number of undiagnosed individuals in the United States, we predict that incorporating @entity3 phenotype screening would identify an additional 400,000 @entity0 with active, untreated @entity1 compared to the conventional pre-screening models.

title: Electronic health record phenotyping improves detection and screening of type 2 XXXX in the general United States population: A cross-sectional, unselected, retrospective study.

answer: @entity1


abstract: PURPOSE: Active surveillance is an approach to low and @entity2 that is designed to decrease overtreatment. Despite close monitoring a small subset of @entity0 progress to @entity1 . We analyzed the clinical and pathological correlates of surveillance in @entity0 who eventually experienced @entity1 . MATERIALS AND METHODS: This was a single center, prospective cohort study. Eligible @entity0 were treated with an expectant approach. The main outcome measure was @entity1 -free survival. Predictive factors for @entity1 were identified. RESULTS: @entity1 developed in 30 of 980 @entity0 , of whom 211 were classified at intermediate risk, including 14 who progressed to @entity1 . Median followup was 6.3 years, median age was 70 years, median @entity3 was 6.2 ng/ml and median time to @entity1 was 8.9 years. @entity1 developed in bone in 18 @entity0 (60%) and in lymph nodes in 13 (43%). @entity3 doubling time less than 3 years (HR 3.7, 95% CI 1.4-9.4, p  =  0.0006), Gleason score 7 (HR 3.0, 95% CI 1.2-7.3, p = 0.0018) and a total of 3  or more positive cores (HR 2.7, 95% CI 1.1-6.8, p = 0.0028) were independent predictors of @entity1 . Although the intermediate risk group was at higher risk for @entity1 , those with Gleason score 6 and @entity3 greater than 10 ng/ml were not at increased risk for @entity1 . @entity1 developed in only 2 @entity0 with Gleason score 6 and neither had surgical pathology grading. CONCLUSION: Active surveillance appears safe in @entity0 at low risk and in select @entity0 at intermediate risk, particularly those with Gleason score 6 and @entity3 greater than 10 ng/ml. @entity0 with elements of Gleason pattern 4 on diagnostic biopsy are at increased risk for eventual @entity1 when treated with an initial conservative approach.

title: Metastatic XXXX in @entity0 Initially Treated with Active Surveillance.

answer: @entity2


abstract: PURPOSE: Active surveillance is an approach to low and @entity2 that is designed to decrease overtreatment. Despite close monitoring a small subset of @entity0 progress to @entity1 . We analyzed the clinical and pathological correlates of surveillance in @entity0 who eventually experienced @entity1 . MATERIALS AND METHODS: This was a single center, prospective cohort study. Eligible @entity0 were treated with an expectant approach. The main outcome measure was @entity1 -free survival. Predictive factors for @entity1 were identified. RESULTS: @entity1 developed in 30 of 980 @entity0 , of whom 211 were classified at intermediate risk, including 14 who progressed to @entity1 . Median followup was 6.3 years, median age was 70 years, median @entity3 was 6.2 ng/ml and median time to @entity1 was 8.9 years. @entity1 developed in bone in 18 @entity0 (60%) and in lymph nodes in 13 (43%). @entity3 doubling time less than 3 years (HR 3.7, 95% CI 1.4-9.4, p  =  0.0006), Gleason score 7 (HR 3.0, 95% CI 1.2-7.3, p = 0.0018) and a total of 3  or more positive cores (HR 2.7, 95% CI 1.1-6.8, p = 0.0028) were independent predictors of @entity1 . Although the intermediate risk group was at higher risk for @entity1 , those with Gleason score 6 and @entity3 greater than 10 ng/ml were not at increased risk for @entity1 . @entity1 developed in only 2 @entity0 with Gleason score 6 and neither had surgical pathology grading. CONCLUSION: Active surveillance appears safe in @entity0 at low risk and in select @entity0 at intermediate risk, particularly those with Gleason score 6 and @entity3 greater than 10 ng/ml. @entity0 with elements of Gleason pattern 4 on diagnostic biopsy are at increased risk for eventual @entity1 when treated with an initial conservative approach.

title: Metastatic @entity2 in XXXX Initially Treated with Active Surveillance.

answer: @entity0


abstract: OBJECTIVE: To determine the utility of cycle day 28 @entity1 (E2) levels in predicting pregnancy outcomes after IVF. DESIGN: Retrospective, cohort study. SETTING: Academic medical center. @entity0 (S): All IVF cycles resulting in a positive pregnancy test result at our center between January 2007 and December 2012 were included. INTERVENTION(S): In  vitro fertilization with fresh embryo transfer. MAIN OUTCOME MEASURE(S): A total of 5,471 IVF cycles were identified. Cycles were stratified by day-28 E2 level (pg/mL) into three groups: A:  <=50; B: 51-100; and C: >100. Outcomes measured were live birth, clinical pregnancy, biochemical, ectopic, and spontaneous abortion rates. RESULT(S): There were 806, 588, and 4,077 IVF pregnancies in groups A, B, and C, respectively. Live birth rates were lower in groups A (15.4%) and B (41.2%) compared with group C (77.4%), representing decreased odds of live birth in @entity0 with E2 levels of  <=50 pg/mL (odd ratio 0.05, 95% confidence interval 0.04-0.07) and in @entity0 with levels of 51-100 pg/mL (odds ratio 0.20, 95% confidence interval 0.17-0.25) compared with @entity0 with levels >100 pg/mL. Rates of biochemical and ectopic pregnancies were higher in groups A (66.5%, 6.20%) and B (30.7%, 3.57%) compared with group C (7.31%, 0.66%). An @entity2 level <50 mIU/mL was associated with increased odds of a biochemical pregnancy and decreased odds of a live birth. CONCLUSION(S): Low E2 levels early in IVF pregnancies are associated with poorer pregnancy outcomes. @entity1 can be used alone or in conjunction with @entity2 levels to predict the odds of a live birth.

title: How low is too low? Cycle day 28 XXXX levels and pregnancy outcomes.

answer: @entity1


abstract: @entity0 can occur after compression of the spinal cord. It is widely accepted that @entity4 leads to @entity5 and ultimately @entity2 due to a narrowed spinal canal. Therefore, an in-depth understanding of the pathogenesis of @entity3 is required to help develop effective clinical interventions. In the present study, we propose a new method of quantitative 3D micro-CT to observe microvascular events in a chronic @entity4 @entity1 model. A total of 36 @entity1 were divided into two groups: sham control group (n = 12) and compressive @entity3 group (n = 24). @entity1 were scarified at four weeks after surgery. In each group, @entity6 micro-vessel immunohistochemical staining was performed in half of the animals, while micro-CT scanning was performed in the other half. Microvessel density (MVD) was measured after immunohistochemical staining, while the vascular index (VI) was measured in 3D micro-CT. In comparison with sham control, abnormal somatosensory evoked potentials (SEP) can be seen in all 24 cases of the compression group, and VI shows the amount of microvessels reduced consistently and significantly (p < 0.01). A significant correlation is also found between MVD and VI (r = 0.95, p < 0.01). These data suggest that quantitative 3D micro-CT is a sensitive and promising tool for investigating microvascular changes during chronic compressive @entity3 .

title: Value of micro-CT for monitoring spinal microvascular changes after chronic XXXX .

answer: @entity4


abstract: Microbial rhodopsins are photoactive proteins, and their binding site can accommodate either all-trans or 13-cis retinal chromophore. The pH dependence of isomeric composition, dark-adaptation rate, and primary events of Anabaena sensory @entity1 (ASR), a microbial @entity1 discovered a decade ago, are presented. The main findings are: (a) Two pKa values of 6.5 and 4.0 assigned to two different protein residues are observed using spectroscopic titration experiments for both ground-state retinal isomers: all-trans, @entity2 ( @entity2 ) and 13-cis, 15-syn ( @entity0 ). The protonation states of these protein residues affect the absorption spectrum of the pigment and most probably the isomerization process of the retinal chromophore. An additional pKa value of 8.5 is observed only for @entity0 -ASR. (b) The isomeric composition of ASR is determined over a wide pH range and found to be almost pH-independent in the dark (>96% @entity2 isomer) but highly pH-dependent in the light-adapted form. (c) The kinetics of dark adaptation is recorded over a wide pH range, showing that the thermal isomerization from @entity0 to @entity2 retinal occurs much faster at high pH rather than under acidic conditions. (d) Primary photochemical events of ASR at pH 5 are recorded using VIS hyperspectral pump-probe spectroscopy with <100 fs resolution and compared with the previously recorded results at pH 7.5. For @entity2 -ASR, these are shown to be almost pH-independent. However, photochemistry of @entity0 -ASR is pH-dependent and slowed down in acidic environments.

title: pH dependence of Anabaena sensory XXXX : retinal isomer composition, rate of dark adaptation, and photochemistry.

answer: @entity1


abstract: The use of alternating electric fields has been recently proposed for the treatment of recurrent @entity2 . In order to predict the electric field distribution in the brain during the application of such @entity0 treating fields (TTF), we constructed a realistic head model from MRI data and placed transducer arrays on the scalp to mimic an FDA-approved medical device. Values for the tissue dielectric properties were taken from the literature; values for the device parameters were obtained from the manufacturer. The finite element method was used to calculate the electric field distribution in the brain. We also included a 'virtual lesion' in the model to simulate the presence of an idealized @entity0 . The calculated electric field in the brain varied mostly between 0.5 and 2.0   V   cm(   -   1) and exceeded 1.0   V   cm(   -   1) in 60% of the total brain volume. Regions of local field enhancement occurred near interfaces between tissues with different conductivities wherever the electric field was perpendicular to those interfaces. These increases were strongest near the ventricles but were also present outside the @entity0 's @entity1 core and in some parts of the gray matter-white matter interface. The electric field values predicted in this model brain are in reasonably good agreement with those that have been shown to reduce @entity0 cell proliferation in vitro. The electric field distribution is highly non-uniform and depends on tissue geometry and dielectric properties. This could explain some of the variability in treatment outcomes. The proposed modeling framework could be used to better understand the physical basis of TTF efficacy through retrospective analysis and to improve TTF treatment planning.

title: Predicting the electric field distribution in the brain for the treatment of XXXX .

answer: @entity2


abstract: The purpose of this study was to expand and validate the @entity0 ( @entity0 ) to detect cartilage damage in the lateral tibiofemoral compartment. We used an iterative 3-step process to develop and validate the lateral @entity0 : development (100 knees), testing (80 knees), and validation (100 knees). The validation set included 100 knees from the @entity1 Initiative that was enriched to include all grades of lateral joint space narrowing (JSN, 0-3). Measurement of the @entity0 was rapid at 7.4 (s.d. 0.73) minutes per knee pair (baseline and follow-up of one knee). The intratester reliability is good (intraclass correlation coefficient (3, 1 model) = 0.86 to 0.98). At baseline, knees with greater KL grade and lateral JSN had a lower mean @entity0 (i.e., greater cartilage damage). Baseline lateral @entity0 is associated with both lateral JSW (r = 0.81 to 0.85, p < 0.01) and HKA (r = -0.30 to -0.33, p < 0.05). The SRM is good (lateral femur SRM = -0.76; lateral tibia SRM = -0.73; lateral tibiofemoral total SRM = -0.87). The lateral tibiofemoral @entity0 quantification allows for rapid evaluation and is reliable and responsive, with good construct validity. It may be an efficient method to measure lateral tibiofemoral articular cartilage in large clinical and epidemiologic studies.

title: Development of a Rapid Cartilage Damage Quantification Method for the Lateral Tibiofemoral Compartment Using Magnetic Resonance Images: Data from the XXXX Initiative.

answer: @entity1


abstract: INTRODUCTION AND HYPOTHESIS: To estimate the incidence rates of stress @entity2 (SUI) surgery among Finnish @entity0 from 1987 to 2009 by age, and to evaluate the trends in SUI surgery. METHODS: We conducted a retrospective register-based study. All SUI procedures on adult @entity0 over age 18  years in Finland were identified from the nationwide Care Register for Health Care. Age-specific incidence rates @entity1 ,000 @entity0 were calculated for each year. The cumulative incidence of SUI surgery was calculated. RESULTS: There were 38,340 procedures for SUI in 1987-2009. The overall age-adjusted incidence rate increased 2.6-fold from 0.5/1,000 @entity0 in 1987 to 1.3/1,000 in 2002, but declined thereafter by 2009 to 0.8/1,000. There was a six-fold increase in the incidence rate in the age group 60-69 years and a ten-fold increase in the age group 70-79 years from 1987 to 2002. These marked increases in operation rates coincided with the increased use of @entity3 ( @entity3 ). In 2002, @entity3 accounted for 96  % of all SUI procedures. Mid-urethral slings with transobturator techniques surpassed @entity3 in popularity in 2007. The life-long cumulative incidence of SUI surgery was 9.9  % in 2002 and 6.3  % in 2009. CONCLUSIONS: The incidence rates of SUI surgery increased significantly in Finland, especially among @entity0 aged 60 to 79  years. Mid-urethral slings have become the dominant procedure.

title: Surgery for stress XXXX in Finland 1987-2009.

answer: @entity2


abstract: MR-HIFU is a new non-invasive treatment modality that can be used for palliation in @entity0 with painful bone @entity1 . Since treatment strategies are mainly focused on the ablation of periosteal nerves, information on the presence and geometry of cortical bone influences the treatment strategy, both in determining the acoustic power and in avoiding safety issues related to far-field heating. Although MRI is available for imaging during treatment, CT is best used for examining the cortical bone. We present a registration method for registering CT and MR images of @entity0 with bone @entity1 prior to therapy. CT and MRI data were obtained from nine @entity0 with metastatic @entity2 at varying locations. A two-step registration approach was used, performing simultaneous rigid registration of all available MR images in the first step and an affine and deformable registration with an additional bone metric in the second step. The performance was evaluated using landmark annotation by clinical observers. An average registration error of 4.5  mm was obtained, which was comparable to the slice thickness of the data. The performance of the registration algorithm was satisfactory, even with differences in MRI acquisition parameters and for various anatomical sites. The obtained CT overlay is useful for treatment planning, as it allows an assessment of the integrity of the cortical bone. CT-MR registration is therefore recommended for HIFU treatment planning of @entity0 with bone @entity1 .

title: Registration of CT to pre-treatment MRI for planning of MR-HIFU ablation treatment of painful bone XXXX .

answer: @entity1


abstract: UNASSIGNED: Objective:To investigate the expression of gap junction protein connexin 26( @entity7 ) in @entity4 ( @entity4 ) and its significance. Methods:The expression of @entity7 in liver tissue was examined by immunohistochemistry staining in 159 paraffin-embeded liver sections, including 20 samples of normal liver tissue, 30 samples of chronic @entity3 , 33 samples of liver @entity2 , and 76 samples of @entity4 . Normal hepatic cell line LO2 and @entity4 cell line SMMC-7721 were used in vitro to verify the characteristics of gap junction and @entity7 expression pattern. The expression and localization of @entity7 were measured by Western blotting and immunofluorescence assay, respectively. The function of gap junction between adjacent cells was detected by dye transfer assay. Results:Compared to normal liver samples, the positive rate of @entity7 was markedly decreased in @entity3 , @entity2 and @entity4 tissues(all P<0.05). The intensity of @entity7 staining was significantly increased in @entity4 tissues compared with those in @entity5 (NCL) tissues(all P<0.05). In NCL tissues, there was a mild to moderated staining of @entity7 which located mainly on the membranes of hepatocytes at intercellular contacts. The positive staining of @entity7 in @entity4 tissues was observed mainly in cytoplasm. Positive @entity7 expression was positively associated with @entity1 size(P=0.036), but not with age, gender, histologic grade, clinical stage, underlying @entity3 and cirhosis, lymph node @entity0 and @entity6 (all P>0.05). Compared with LO2 cells, an aberrant expression and distribution of @entity7 in SMMC-7721 cells was confirmed, which may lead to a decreased function of gap junctions. CONCLUSIONS: The aberrant expression and distribution of @entity7 protein may be associated with hepatocarcinogenesis, and the residual gap junction in @entity4 may provide a new target for treatment of @entity4 .

title: [Expression of gap junction protein connexin 26 in human XXXX and its significance].

answer: @entity4


abstract: OBJECTIVE: To discuss the diagnostic value of @entity1 activity with multi-slice CT enterography. METHODS: MSCTE examination data of 88 cases of @entity3 @entity0 by clinical, endoscopy, pathology confirmed in Sir Run Run Shaw Hospital from January 2013 to June 2014 were analysed. According to the Harvey-Bradshaw index, all of @entity3 @entity0 were divided into the active phase group and remission phase group. Imaging findings of two groups were compared. To explore the relationship between MSCTE findings and CRP/ESR of @entity3 @entity0 . RESULTS: The wall thickness (8.2    2.6) mm and enhancement degree (112    16) HU in active phase group were higher than the wall thickness (5.4    1.6) mm and enhancement degree (93    17) HU in the remission phase group (P < 0.01). The incidences of intestinal wall stratification enhancement, comb sign, swollen lymph nodes, @entity6 , @entity7 , @entity5 in active phase group (88.5%, 72.1%, 77%, 45.9%, 26.2%, 65.6%) were significantly higher than those in remission phase group (29.6%, 18.5%, 25.9%, 0, 3.7%, 37%) (P < 0.05). The incidences of intestinal wall homogeneous enhancement in remission phase group (70.4%) were higher than those in active phase group (11.5%) (P < 0.01). There was no significant difference in the incidences of abscesse in two groups (P > 0.05). CRP was correlated with the wall thickness and enhancement degree, abnornlal mesentery vascularity, @entity4 , @entity6 , @entity7 (r > 0.2, P < 0.05). ESR was correlated with the wall enhancement degree, abnormal mesentery vascularity, @entity4 and @entity6 (r > 0.2, P < 0.05). CONCLUSION: CT enterography can adequately demonstrate @entity2 and assess the presence of extramural complications, which are helpful in evaluating the activity of @entity1 .

title: [Evaluation of XXXX activity with multi-slice CT enterography].

answer: @entity1


abstract: AIMS AND OBJECTIVES: To assess the feasibility, acceptability and potential effectiveness of Dignity Therapy to improve the quality of life and reduce @entity2 in older @entity0 with early stage @entity1 . BACKGROUND: @entity1 is a syndrome with several causes that leads to a progressive decline in multiple areas of functioning. The maintenance of dignity and enhancement of quality of life are key elements of care. Meaningful communication may become more difficult with condition progression. Improvements in communication may have positive effects on the @entity0 's quality of life. Dignity Therapy is a short psychotherapeutic intervention that uses a trained therapist to take the @entity0 with @entity1 through a guided interview process, producing a 'generativity' document that creates a lasting, written legacy during a time when they are still able to communicate well. DESIGN AND METHOD: This was a feasibility mixed method study. Dignity Therapy was undertaken with @entity0 diagnosed as having early stage @entity1 . Data were gathe-red from pre- and post-Dignity Therapy interviews, a focus group, interviews with key  stakeholders, and three outcome measures: The Herth Hope Index; The @entity0 Dignity Inventory; Perceived Quality of Life/Satisfaction with Quality Life Ratings. FINDINGS: This study demonstrated that Dignity Therapy is feasible, acceptable and potentially effective for older @entity0 with @entity1 . Three overarching themes emerged: A life in context, A key to connect and Personal legacy. CONCLUSIONS: We recommend that this feasibility study forms the basis for further study, advocating the prospective benefits to @entity0 with @entity1 , families and nursing practice. IMPLICATIONS FOR PRACTICE: Dignity Therapy, as a psychosocial intervention, has the potential to improve the quality of life and enhance @entity0 centred care for @entity0 with @entity1 .

title: Living well with XXXX : enhancing dignity and quality of life, using a  novel intervention, Dignity Therapy.

answer: @entity1


abstract: OBJECTIVE: @entity12 portends the highest mortality among @entity2 , despite primarily being a disease of adolescents and younger adults. Although some of this mortality risk is attributable to suicide, many @entity3 are likely cardiovascular in etiology. Recent studies suggest that adverse myocardial structural changes occur in this condition, which could underlie the increased mortality. Given limited prevalence of severe @entity5 there is a paucity of clinical and autopsy data to discern an exact cause of @entity3 . METHODS: Given this background we conducted a systematic review of the medical literature to provide a contemporary summary of the pathobiologic sequelae of severe @entity1 . We sought to elucidate the @entity12 in four cardiovascular domains: structural, repolarization/conduction, hemodynamic, and peripheral vascular. RESULTS: A number of @entity4 associated with @entity12 have been described in the literature, including pericardial and valvular pathology, changes in left ventricular mass and function, @entity7 , @entity11 , @entity6 , and dysregulation in peripheral vascular contractility. Despite the prevalent theory that malignant @entity8 are implicated as a cause of @entity9 in this disorder, data to support this causal relationship are lacking. DISCUSSION: It is reasonable to obtain routine electrocardiography and measurements of orthostatic vital signs in @entity0 presenting with @entity12 . Echocardiography is generally not indicated unless prompted by clinical signs of disease. Admission to an inpatient unit with telemetry monitoring is recommended for @entity0 with severe sinus @entity11 or junction rhythm, marked prolongation of the corrected QT interval, or @entity10 .    2015 Wiley Periodicals, Inc. (Int J Eat Disord 2015).

title: XXXX : A systematic review.

answer: @entity1


abstract: The expansion of molecular genetic knowledge leads to targeted therapy which is a common part of @entity1 treatment. Targeted agents also exist for @entity0 . However, new efficient molecules are urgently needed. On one hand, there are @entity1 subgroups where we do not have efficient targeted drugs, on the other hand, the results of established @entity1 therapies can be improved by interfering with another signal transduction pathway. @entity3 is a targeted agent which was effective in several clinical trials and became registered for treatment of hormone receptor positive @entity0 . This article summarizes the results of @entity0 @entity3 trials. The results of two phase 3 trials are available. In the BOLERO-2 trial @entity4 was compared with the combination of @entity4 and @entity3 , while in BOLERO-3 trial trastuzumab and @entity2 were investigated with or without @entity3 . In both trials the progression-free survival was significantly longer in the experimental arm. The overall survival data of BOLERO-2 trial, a secondary end point, are also available. The 4.4 month benefit in the experimental arm is clinically important but it has not reached the level of statistical significance. We have not had biomarkers so far that could help us to identify a subgroup of @entity1 sensitive to @entity3 .

title: [BOLERO -- another remarkable step in treatment of XXXX ].

answer: @entity0


abstract: OBJECTIVES: To analyze a cohort of @entity0 with HPV positive, @entity4 ( @entity4 ) treated with lower radiation dose to clinically involved lymph nodes. MATERIALS AND METHODS: We retrospectively identified @entity0 with HPV positive, @entity4 treated with definitive chemoradiotherapy (70-74.4Gy) to the primary site and, since a post-radiation neck dissection was planned, 54Gy to the involved nodal areas. Neck dissection was ultimately omitted in all cases due to complete response. All @entity0 were treated with a 3 field approach with sequential boost plans. Composite plans were generated retrospectively and primary @entity2 and lymph node GTVs were contoured and nodes were expanded by 5mm to form a CTV. Mean dose, dose to 95% (D95) and dose to 99% (D99) were determined. RESULTS: Fifty @entity0 treated from 2008 to 2010 with 113 involved nodes were identified. The median age was 57years, and 6%, 46%, and 48% were current, former, and never smokers. Ninety percent of @entity0 received concurrent @entity3 based chemotherapy. Median D95 and D99 to involved nodes were 59.8Gy and 55.9Gy respectively. At a median follow up of 54.1months, two @entity0 developed nodal failure and four developed @entity1 . Five year loco-regional control, disease free survival and overall survival were 96%, 81% and 86% respectively. CONCLUSION: In this exploratory analysis, regional lymph node control in HPV positive @entity2 was not compromised by dose de-escalated radiotherapy to involved nodes in the setting of concurrent @entity3 based chemotherapy.

title: Regional control is preserved after dose de-escalated radiotherapy to involved lymph nodes in HPV positive XXXX .

answer: @entity2


abstract: Mortality for @entity0 presenting with @entity1 ( @entity1 ) complicated by @entity3 ( @entity3 ) and @entity2 is very high even with surgical repair. We report our experience regarding utilization of TandemHeart, a percutaneous ventricular assist device (pVAD) as an adjunct to the treatment of these @entity0 . Retrospective case series study design included a total of 11 @entity0 with post- @entity1 @entity3 and severe refractory @entity2 who received pVAD support at our institution. Three @entity0 underwent immediate surgical repair and received pVAD support for postcardiotomy @entity2 for 2, 4, and 7 days, respectively. However, all three died. The other eight @entity0 had pVAD implanted prior to surgical repair in order to rest the myocardium before operation. Hemodynamics improved immediately after pVAD placement, and after receiving pVAD support for 7    3 days, they underwent surgical @entity3 repair. Their total pre- and post-surgical pVAD support was 14    4 days. All eight survived 30 days postoperatively. At 6 months postsurgery overall survival rate was 75%. Our small series of these @entity4 @entity0 shows a trend toward better survival after immediate pVAD placement to stabilize the @entity0 and allow for myocardial maturation before surgical @entity3 repair.

title: Perioperative use of TandemHeart percutaneous ventricular assist device in surgical repair of postinfarction XXXX .

answer: @entity3


abstract: PURPOSE:: To evaluate the visual outcome of optical coherence tomography-based ranibizumab monotherapy in Korean @entity0 with @entity4 and identify prognostic factors of visual outcome. METHODS:: A prospective single-arm clinical study of 31 @entity4 @entity0 who underwent 3 consecutive monthly intravitreal ranibizumab injections was conducted. Additional treatment was given based on optical coherence tomography at monthly follow-ups over 24 months. RESULTS:: Best-corrected visual acuity improved from 48.7    19.3 to 56.3    19.1 letters at 24 months (P = 0.010). Total cumulative numbers of injection were 5.5    2.2 and 7.7    3.4 times at 12 and 24 months, respectively. Older age, larger @entity3 size, and poor initial best-corrected visual acuity were associated with poor visual outcome. Final best-corrected visual acuity was significantly worse with Stage 3 disease (70.4    5.1, 62.3    11.6, 46.2    22.3 letters improved in each stage; P = 0.015). Among factors associated with poor visual outcome, only the stage of @entity4 remained statistically significant on multiple linear regression analysis (P = 0.006). Although baseline best-corrected visual acuity was similar, Stage 3 @entity0 exhibited limited visual improvement despite anatomical improvement, and more recurrences requiring more injections. CONCLUSION:: @entity4 may be successfully managed with ranibizumab monotherapy in Korean @entity0 , with the number of treatments required comparable to other forms of neovascular age-related @entity2 . However, visual improvement was limited in late-stage @entity1 .

title: OPTICAL COHERENCE TOMOGRAPHY-BASED RANIBIZUMAB MONOTHERAPY FOR RETINAL ANGIOMATOUS PROLIFERATION IN KOREAN XXXX .

answer: @entity0


abstract: PURPOSE: This review compared knee muscle activity between @entity1 ( @entity1 ) @entity0 and healthy controls during gait, to find out whether the available electromyography (EMG) studies support Quadriceps (Q-ceps) inhibition or hamstring facilitation during gait in @entity1 @entity0 . METHOD: A systematic review was conducted to retrieve the EMG studies of knee muscles during gait in @entity1 @entity0 . Cochrane library, PubMed, Medline, Ovid, CINAHL and Science Direct databases were searched entries from 1995 through October 2014 using the terms "anterior cruciate ligament" OR "ACL", "electromyography" Or "EMG" "gait" Or "walking". Articles that assessed subjects with ACL rupture that used surface EMG to assess the knee muscle activity were included. The quality of the included papers was assessed using the Critical Appraisal Skills Programme tool for observational studies. RESULT: In total, 13 studies met the inclusion criteria. Seven studies consistently found no significant difference in magnitude of activity or timing of Q-ceps muscle between the chronic @entity1 @entity0 and control subjects. Two studies on acute @entity1 @entity0 and three studies on @entity1 @entity0 with unstable knee found the significantly reduced Q-ceps activity compared to control subjects. Six studies showed the significantly greater hamstring activity, and three studies found prolonged duration of activity in @entity1 @entity0 compared to the control subjects. CONCLUSION: This review highlighted that the results of the studies are in favour of increased hamstring muscular activity. However, decreased Q-ceps activation exists in the acute stage and in @entity1 @entity0 that experience knee instability (non-copers). LEVEL OF EVIDENCE: III.

title: Knee muscle activity during gait in XXXX with anterior cruciate ligament injury: a systematic review of electromyographic studies.

answer: @entity0


abstract: BACKGROUND: We aimed to comprehensively evaluate lipoprotein profile including lipid particle size following a lifestyle intervention in @entity1 ( @entity1 ) volunteers and to assess the associations between lipoprotein subfractions and @entity3 ( @entity3 ) - a surrogate indicator of @entity2 . METHODS: 100 @entity0 (50-70 years) from the RESOLVE trial, underwent a one-year follow-up beginning with a three-week residential program combining high exercise volume (15-20 h/week), restrictive diet (-500 kcal/day), and education. For baseline references, 40 aged-matched healthy controls were recruited. Independent associations between subfractions of lipoproteins and @entity3 were evaluated using a generalized estimating equations model accounting for variation in correlations between repeated measures. The lipoprotein subfractions profile was assessed using Lipoprint   electrophoresis allowing to separate: the very low-density lipoprotein (VLDL) fraction, then the intermediate-density lipoprotein (IDL) C, B and A, the low-density lipoprotein (LDL) with subfractions 1 and 2 as large LDL and subfractions 3 to 7 as small dense LDL (sdLDL), and the high density lipoprotein (HDL) subfractions categorized into large, intermediate, and small HDL. Apolipoproteins A1 and B were also measured. RESULTS: 78 @entity0 completed the program. At baseline, apolipoproteins B/A1, VLDL, sdLDL and small HDL were higher in @entity1 than in healthy controls; IDL, LDL size, large and intermediate HDL were lower. Despite time-related regains during the follow-up, lipoprotein subfractions traditionally involved in cardiovascular risk, such as sdLDL, improved immediately after the residential program with values closest to those of healthy controls. @entity3 improved throughout the lifestyle intervention. Using a generalized estimating equations model, none of the subfractions of lipoproteins nor apolipoproteins were linked to @entity3 . CONCLUSIONS: Lipoprotein subfractions traditionally involved in CVR, decreased after the 3-week residential program. During a 12 month follow-up, the time-related regains remained closer to the values of healthy controls than they were at baseline. @entity3 improved throughout the lifestyle intervention. However, we failed to demonstrate a link between some lipoprotein subfractions and the atherogenicity directly measured from the wall thickness of arteries ( @entity3 ). Further investigations are required to explore the atherogenicity of lipoprotein subfractions. TRIAL REGISTRATION: NCT00917917.

title: Atherogenic subfractions of lipoproteins in the treatment of XXXX by physical activity and diet - the RESOLVE trial.

answer: @entity1