abstract: Non-sustained @entity5 ( @entity5 ) in the late post @entity2 ( @entity2 ) period (7-21 days) has been reported to be a predictor of @entity4 . We suspected that @entity0 with 3 beat @entity5 on Holter monitoring in the late @entity6 period would demonstrate electrical instability at electrophysiologic studies. Forty-seven @entity0 were identified as having at least 3 beat @entity5 on Holter monitoring. Eighteen @entity0 refused electrophysiologic studies or were not referred by their attending physician. The mean ejection fraction of this group was 43 +/- 16%. Eight @entity0 have died, 3 sudden deaths in 13 +/- 5 months, a 17% incidence of @entity4 . Twenty-nine @entity0 underwent invasive electrophysiologic studies. Their mean ejection fraction was 37 +/- 7%, and 28 had inducible, 18 sustained @entity5 and 10 non-sustained @entity5 . No complications were noted with electrophysiological testing in the post @entity6 @entity0 . Using programmed electrical stimulation studies an effective antiarrhythmic agent preventing @entity5 induction (usually experimental) could be found for each @entity0 . After a mean follow-up of 12.5 +/- 4 months, the @entity0 without inducible @entity5 is alive and 26 of the 28 "inducible" @entity0 are alive and well. Two @entity0 died, one of @entity1 and one due to pump failure following a second @entity2 . No sudden deaths were observed in this group. Two @entity0 had @entity3 and were treated by alternative antiarrhythmic therapy that was also effective at the initial electrophysiologic studies. Thus, PES studies post @entity2 are safe and may be an effective way to assess therapy for @entity0 in the early post @entity2 period, identified at high risk for @entity4 .

title: Therapy for late post @entity6 XXXX .

answer: @entity5


abstract: In these studies we examined the temporal parameters of @entity1 (E2) priming required before @entity4 (P4) amplifies the surge release of luteinizing hormone (LH) in short-term ovariectomized (OVX) @entity0 . Thereafter, we correlated the time of appearance and concentrations of @entity3 nuclear (E2Rn) and progestin cytosol (PRc) receptors in brain regions known to be involved in the surge release of LHRH. @entity2 receptor concentrations were also measured in the pituitary gland. 1 week after OVX (day 0), Silastic capsules containing E2 (150 micrograms/ml in oil s.c.) were placed at 09.00 h. The serum E2 concentrations produced by these capsules peaked (41 +/- 2.1 pg/ml) at 10.00 h on day 0 and declined thereafter to values which ranged between 19 and 10 pg/ml on days 1 through 4. Some of these E2-treated @entity0 also received 2 P4-containing Silastic capsules (50 mg/ml s.c. in oil) at 09.00 h on either days 0, 1, 2, 3 or 4. Serum P4 concentrations produced by such capsules were 9.3 +/- 0.5 ng/ml. Blood was collected sequentially at 09.00 h and at hourly intervals from 12.00-18.00 h on the day that the animals received the P4 capsules and 10.00 and 15.00 h samples also were taken from each group the next day. LH surges occurred in these E2-treated @entity0 in the afternoons of days 2-4, but not on days 0 and 1. P4 treatment on day 1 elicited an LH surge and on days 2-4 it amplified plasma LH surge concentrations and advanced by 1 h the time of release of this gonadotropin.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Correlation of luteinizing hormone surges with XXXX nuclear and progestin cytosol receptors in the hypothalamus and pituitary gland. II. Temporal @entity1 effects.

answer: @entity3


abstract: In these studies we examined the temporal parameters of @entity1 (E2) priming required before @entity4 (P4) amplifies the surge release of luteinizing hormone (LH) in short-term ovariectomized (OVX) @entity0 . Thereafter, we correlated the time of appearance and concentrations of @entity3 nuclear (E2Rn) and progestin cytosol (PRc) receptors in brain regions known to be involved in the surge release of LHRH. @entity2 receptor concentrations were also measured in the pituitary gland. 1 week after OVX (day 0), Silastic capsules containing E2 (150 micrograms/ml in oil s.c.) were placed at 09.00 h. The serum E2 concentrations produced by these capsules peaked (41 +/- 2.1 pg/ml) at 10.00 h on day 0 and declined thereafter to values which ranged between 19 and 10 pg/ml on days 1 through 4. Some of these E2-treated @entity0 also received 2 P4-containing Silastic capsules (50 mg/ml s.c. in oil) at 09.00 h on either days 0, 1, 2, 3 or 4. Serum P4 concentrations produced by such capsules were 9.3 +/- 0.5 ng/ml. Blood was collected sequentially at 09.00 h and at hourly intervals from 12.00-18.00 h on the day that the animals received the P4 capsules and 10.00 and 15.00 h samples also were taken from each group the next day. LH surges occurred in these E2-treated @entity0 in the afternoons of days 2-4, but not on days 0 and 1. P4 treatment on day 1 elicited an LH surge and on days 2-4 it amplified plasma LH surge concentrations and advanced by 1 h the time of release of this gonadotropin.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Correlation of luteinizing hormone surges with @entity3 nuclear and progestin cytosol receptors in the hypothalamus and pituitary gland. II. Temporal XXXX effects.

answer: @entity1


abstract: Increasing dosages of two potent diuretic agents (5, 10, 20 mg @entity6 or 40, 80, 160 mg @entity3 ) were compared in 35 @entity0 with @entity1 and @entity2 . In cases with insufficient blood pressure control, 10 mg @entity5 was given as a second drug. Finally, @entity0 not responding to a betablocker-diuretic combination received 100 mg @entity4 as a third drug. Both diuretics had comparable antihypertensive potency during a treatment period of up to 12 weeks. Maximal antihypertensive response was observed under 10 mg @entity6 or 160 mg @entity3 . However, only in 25% of our @entity0 blood pressure was normalized with diuretic monotherapy ( @entity6 or @entity3 ). The remaining cases needed either an additional betablocker or a combination of three different antihypertensive agents. Under these conditions a substantial proportion of our @entity0 (20%) did not reach the therapeutic goal (diastolic blood pressure less than 95 mm Hg). These results document the difficulties of @entity1 management in @entity2 . An early change to the stepped-care approach should be made in all cases with insufficient blood pressure response to potent diuretics.

title: [Diuretics and antihypertensive agents in chronic kidney insufficiency: comparison of the effects of XXXX and @entity3 ].

answer: @entity6


abstract: Increasing dosages of two potent diuretic agents (5, 10, 20 mg @entity6 or 40, 80, 160 mg @entity3 ) were compared in 35 @entity0 with @entity1 and @entity2 . In cases with insufficient blood pressure control, 10 mg @entity5 was given as a second drug. Finally, @entity0 not responding to a betablocker-diuretic combination received 100 mg @entity4 as a third drug. Both diuretics had comparable antihypertensive potency during a treatment period of up to 12 weeks. Maximal antihypertensive response was observed under 10 mg @entity6 or 160 mg @entity3 . However, only in 25% of our @entity0 blood pressure was normalized with diuretic monotherapy ( @entity6 or @entity3 ). The remaining cases needed either an additional betablocker or a combination of three different antihypertensive agents. Under these conditions a substantial proportion of our @entity0 (20%) did not reach the therapeutic goal (diastolic blood pressure less than 95 mm Hg). These results document the difficulties of @entity1 management in @entity2 . An early change to the stepped-care approach should be made in all cases with insufficient blood pressure response to potent diuretics.

title: [Diuretics and antihypertensive agents in chronic kidney insufficiency: comparison of the effects of @entity6 and XXXX ].

answer: @entity3


abstract: Bone sialoprotein ( @entity8 ) is a major non-collagenous protein found almost exclusively in bone and other mineralized tissues including enamel, dentin and cementum. Although a role for @entity8 in mineralization has been indicated, @entity8 also appears to function in patho-physiological processes, including the @entity2 of @entity0 cells to bone. The purpose of this study was to determine the role of @entity8 in the homing of @entity3 cells and to provide insights into the role of @entity8 in physiological as well as pathological processes. We established cultures of MDA-231 @entity0 cells stably transfected with DNA constructs of pIRES2-EGFP (green fluorescent protein) expressing @entity1 @entity8 ( @entity8 ) cDNA (231BSP) under a @entity6 promoter, or with an antisense sequence of @entity8 cDNA (231BSPAS), or with an empty vector as a control (231EV). These 3 cell groups were selected for @entity7 resistance using G418 and analyzed by flow cytometry for GFP expression. The resultant cultured cells expressed different levels of @entity8 as detected by RT-PCR and Western blot. Among the three, 231BSP expressed the highest levels of @entity8 while 231BSPAS expressed the lowest. The capacity of the @entity3 cells to metastasize to bone was determined in @entity4 (5 in each group) by intra-cardiac injection of the cells from the 3 different groups. Four weeks after inoculation, radiological examination revealed that all the 5 @entity4 in the 231BSP cell group had developed osteolytic bone @entity2 . In the 231BSPAS group only 1 @entity4 demonstrated metastatic @entity5 while 3 out of 5 @entity4 in the control group (231EV) developed metastatic lesions in the bone. These results strongly suggest that @entity8 over-expression in @entity1 @entity3 cells can enhance bone @entity2 of MDA-231 cells whereas repressed expression of @entity8 , using antisense @entity8 cDNA, inhibits this effect in a @entity4 model.

title: Over-expression of bone sialoprotein enhances bone @entity2 of XXXX @entity0 cells in a @entity4 model.

answer: @entity1


abstract: Bone sialoprotein ( @entity8 ) is a major non-collagenous protein found almost exclusively in bone and other mineralized tissues including enamel, dentin and cementum. Although a role for @entity8 in mineralization has been indicated, @entity8 also appears to function in patho-physiological processes, including the @entity2 of @entity0 cells to bone. The purpose of this study was to determine the role of @entity8 in the homing of @entity3 cells and to provide insights into the role of @entity8 in physiological as well as pathological processes. We established cultures of MDA-231 @entity0 cells stably transfected with DNA constructs of pIRES2-EGFP (green fluorescent protein) expressing @entity1 @entity8 ( @entity8 ) cDNA (231BSP) under a @entity6 promoter, or with an antisense sequence of @entity8 cDNA (231BSPAS), or with an empty vector as a control (231EV). These 3 cell groups were selected for @entity7 resistance using G418 and analyzed by flow cytometry for GFP expression. The resultant cultured cells expressed different levels of @entity8 as detected by RT-PCR and Western blot. Among the three, 231BSP expressed the highest levels of @entity8 while 231BSPAS expressed the lowest. The capacity of the @entity3 cells to metastasize to bone was determined in @entity4 (5 in each group) by intra-cardiac injection of the cells from the 3 different groups. Four weeks after inoculation, radiological examination revealed that all the 5 @entity4 in the 231BSP cell group had developed osteolytic bone @entity2 . In the 231BSPAS group only 1 @entity4 demonstrated metastatic @entity5 while 3 out of 5 @entity4 in the control group (231EV) developed metastatic lesions in the bone. These results strongly suggest that @entity8 over-expression in @entity1 @entity3 cells can enhance bone @entity2 of MDA-231 cells whereas repressed expression of @entity8 , using antisense @entity8 cDNA, inhibits this effect in a @entity4 model.

title: Over-expression of bone sialoprotein enhances bone @entity2 of @entity1 XXXX cells in a @entity4 model.

answer: @entity0


abstract: Bone sialoprotein ( @entity8 ) is a major non-collagenous protein found almost exclusively in bone and other mineralized tissues including enamel, dentin and cementum. Although a role for @entity8 in mineralization has been indicated, @entity8 also appears to function in patho-physiological processes, including the @entity2 of @entity0 cells to bone. The purpose of this study was to determine the role of @entity8 in the homing of @entity3 cells and to provide insights into the role of @entity8 in physiological as well as pathological processes. We established cultures of MDA-231 @entity0 cells stably transfected with DNA constructs of pIRES2-EGFP (green fluorescent protein) expressing @entity1 @entity8 ( @entity8 ) cDNA (231BSP) under a @entity6 promoter, or with an antisense sequence of @entity8 cDNA (231BSPAS), or with an empty vector as a control (231EV). These 3 cell groups were selected for @entity7 resistance using G418 and analyzed by flow cytometry for GFP expression. The resultant cultured cells expressed different levels of @entity8 as detected by RT-PCR and Western blot. Among the three, 231BSP expressed the highest levels of @entity8 while 231BSPAS expressed the lowest. The capacity of the @entity3 cells to metastasize to bone was determined in @entity4 (5 in each group) by intra-cardiac injection of the cells from the 3 different groups. Four weeks after inoculation, radiological examination revealed that all the 5 @entity4 in the 231BSP cell group had developed osteolytic bone @entity2 . In the 231BSPAS group only 1 @entity4 demonstrated metastatic @entity5 while 3 out of 5 @entity4 in the control group (231EV) developed metastatic lesions in the bone. These results strongly suggest that @entity8 over-expression in @entity1 @entity3 cells can enhance bone @entity2 of MDA-231 cells whereas repressed expression of @entity8 , using antisense @entity8 cDNA, inhibits this effect in a @entity4 model.

title: Over-expression of bone sialoprotein enhances bone XXXX of @entity1 @entity0 cells in a @entity4 model.

answer: @entity2


abstract: Bone sialoprotein ( @entity8 ) is a major non-collagenous protein found almost exclusively in bone and other mineralized tissues including enamel, dentin and cementum. Although a role for @entity8 in mineralization has been indicated, @entity8 also appears to function in patho-physiological processes, including the @entity2 of @entity0 cells to bone. The purpose of this study was to determine the role of @entity8 in the homing of @entity3 cells and to provide insights into the role of @entity8 in physiological as well as pathological processes. We established cultures of MDA-231 @entity0 cells stably transfected with DNA constructs of pIRES2-EGFP (green fluorescent protein) expressing @entity1 @entity8 ( @entity8 ) cDNA (231BSP) under a @entity6 promoter, or with an antisense sequence of @entity8 cDNA (231BSPAS), or with an empty vector as a control (231EV). These 3 cell groups were selected for @entity7 resistance using G418 and analyzed by flow cytometry for GFP expression. The resultant cultured cells expressed different levels of @entity8 as detected by RT-PCR and Western blot. Among the three, 231BSP expressed the highest levels of @entity8 while 231BSPAS expressed the lowest. The capacity of the @entity3 cells to metastasize to bone was determined in @entity4 (5 in each group) by intra-cardiac injection of the cells from the 3 different groups. Four weeks after inoculation, radiological examination revealed that all the 5 @entity4 in the 231BSP cell group had developed osteolytic bone @entity2 . In the 231BSPAS group only 1 @entity4 demonstrated metastatic @entity5 while 3 out of 5 @entity4 in the control group (231EV) developed metastatic lesions in the bone. These results strongly suggest that @entity8 over-expression in @entity1 @entity3 cells can enhance bone @entity2 of MDA-231 cells whereas repressed expression of @entity8 , using antisense @entity8 cDNA, inhibits this effect in a @entity4 model.

title: Over-expression of bone sialoprotein enhances bone @entity2 of @entity1 @entity0 cells in a XXXX model.

answer: @entity4


abstract: Although parental administration of @entity3 promotes intestinal adaptation, it is controversial whether enteral @entity3 is effective after small bowel resection. To further evaluate the benefits of enteral supplementation, peptide and @entity2 peptide transporter function must be considered. We evaluated the effect of enteral @entity4 based on the alteration of peptide and @entity2 transporter expressions after massive small intestinal resection. @entity0 underwent 80% proximal intestinal resection. Expression of the glutaminase (GA), @entity2 transporter B0 and peptide transporter @entity5 mRNA in the residual intestinal cells was initially examined by Northern blot analysis. @entity0 with a small bowel received a bolus supplement of @entity3 (2.0 g/kg/day) + @entity1 (1.22 g/kg/day) mixture, @entity4 (2.972/kg/day) or saline for 3 days from one day before operation. On the 3rd postoperative day (POD) and the 7th POD, residual intestinal tissue was removed, and mucosal parameters were measured. The GA activity and GA mRNA significantly increased on the 1st POD. Although the levels of B0 mRNA gradually decreased, the @entity5 mRNA increased after surgery, and reached 150% of the initial level on the 5th POD. In the @entity0 administered @entity4 , mucosal wet weight and protein content similarly increased with increasing villus height on the 7th POD. Enteral supplementation with @entity4 but not @entity3 + @entity1 mixture promotes intestinal adaptation as evidenced by increased peptide transport after intestinal resection.

title: Enteral XXXX supplement promotes intestinal adaptation in @entity0 .

answer: @entity4


abstract: Although parental administration of @entity3 promotes intestinal adaptation, it is controversial whether enteral @entity3 is effective after small bowel resection. To further evaluate the benefits of enteral supplementation, peptide and @entity2 peptide transporter function must be considered. We evaluated the effect of enteral @entity4 based on the alteration of peptide and @entity2 transporter expressions after massive small intestinal resection. @entity0 underwent 80% proximal intestinal resection. Expression of the glutaminase (GA), @entity2 transporter B0 and peptide transporter @entity5 mRNA in the residual intestinal cells was initially examined by Northern blot analysis. @entity0 with a small bowel received a bolus supplement of @entity3 (2.0 g/kg/day) + @entity1 (1.22 g/kg/day) mixture, @entity4 (2.972/kg/day) or saline for 3 days from one day before operation. On the 3rd postoperative day (POD) and the 7th POD, residual intestinal tissue was removed, and mucosal parameters were measured. The GA activity and GA mRNA significantly increased on the 1st POD. Although the levels of B0 mRNA gradually decreased, the @entity5 mRNA increased after surgery, and reached 150% of the initial level on the 5th POD. In the @entity0 administered @entity4 , mucosal wet weight and protein content similarly increased with increasing villus height on the 7th POD. Enteral supplementation with @entity4 but not @entity3 + @entity1 mixture promotes intestinal adaptation as evidenced by increased peptide transport after intestinal resection.

title: Enteral @entity4 supplement promotes intestinal adaptation in XXXX .

answer: @entity0


abstract: HISTORY AND CLINICAL FINDINGS: A 60-year-old @entity0 had a dacron aortofemoral bypass graft inserted to replace a ruptured infrarenal @entity10 . He subsequently had tachyarrhythmic @entity9 with @entity7 , NYHA class IV, and diffuse @entity6 associated with watery @entity5 . INVESTIGATIONS: Stool tests merely demonstrated @entity11 . Abdominal ultrasound revealed intestinal loops with thickened walls and decreased peristalsis. Coloscopy demonstrated a retroperitoneal intestinal perforation with @entity8 formation resulting from @entity1 which had also uncovered the vascular prosthesis near the @entity8 . DIAGNOSIS: Ischemic transmural @entity2 with retroperitoneal intestinal perforation. TREATMENT AND COURSE: The rectosigmoid colon was resected and an end-colostomy made with closure of the rectal stump (Hartmann's operation). The uncovered right limb of the vascular graft was covered completely and was discharged, being now mobile using a walking frame. There was no evidence of @entity4 in the dacron prosthesis. CONCLUSION: A transmural progression of an @entity3 should be considered as a late sequela after emergency vascular reconstruction of the abdominal aorta. Even if symptoms are mild, early postoperative sigmoidoscopy is indicated.

title: [ XXXX after vascular reconstruction of an abdominal aortic aneurysm].

answer: @entity5


abstract: Between 1960 and 1982, 64 operations were performed for @entity2 of the cervical esophagus including the cervicothoracic segment. Of these 64 @entity0 , 12 underwent cervical esophagectomy and 52 had total esophagectomy. Visceral replacements were employed in 61 @entity0 by the skin flap (3 cases), the intestine pedicle graft (10 cases), and the stomach tube (48 cases). The operative mortality rate associated with cervical esophagectomy was 33.3% and that with total esophagectomy was 5.8%. The 5-year survival rate for @entity0 who had cervical esophagectomy was 16.7% and that for @entity0 with total esophagectomy was 30.0%. A direct comparison of the surgical results of cervical and total esophagectomy should not be discussed at the same level, because the cervical esophagectomy operations were performed before 1967. However, the discussion of histologic examinations for removed lymph nodes and resected esophagus will be of value. Analysis of these histologic findings was performed aggressively and we obtained the following results. Total esophagectomy completely removes the intramural invasive @entity1 cells in the anal stump of resected esophagus, and then dissection of the intrathoracic, including cervical, lymph nodes is possible. In addition to these merits, stomach replacement for esophageal reconstruction has the advantage of the only anastomosis (pharyngogastrostomy) as compared with the other visceral replacements. For these reasons it may be recommended that total esophagectomy with stomach replacement is adequate for the treatment of the advanced @entity2 situated in the cervical esophagus.

title: Analysis of surgical treatment for XXXX situated in the cervical esophagus.

answer: @entity2


abstract: PURPOSE: Transgenic @entity1 models are proving to be invaluable in our effort to understand the molecular basis of @entity2 (CaP). We review and discuss how current animal models have contributed to our understanding of the metastatic cascade and how transgenic technology is being used to develop the next generation of @entity1 models. Our goal is to provide a review of the recent advances and provide a framework for further studies. MATERIALS AND METHODS: We performed a MEDLINE search of the literature on CaP @entity0 transgenic and animal models. RESULTS: We present a summary of the characteristics of nine different animal models of CaP. Each model is unique and provides valuable insight into the molecular mechanisms governing the progression of CaP. Our experience with transgenic models and all the new data from the literature predicts that we will be able to develop genetically engineered @entity1 that accurately mimic the heterogeneity, @entity3 -independent growth, and metastatic spread seen in clinical disease. CONCLUSION: In order to elucidate the molecular mechanisms of CaP @entity0 , it will be necessary to compare gene and protein expression patterns and biochemical analyses of clinical metastatic disease with data obtained from current models. We will also need to refine our ability to engineer and characterize genetic perturbation models. This type of integrative and iterative approach should facilitate better understanding of the molecular biology of CaP metastases.

title: Models of XXXX : a transgenic perspective.

answer: @entity2


abstract: In a retrospective survey of 195 @entity0 with spontaneous pneumothorax, 100 had a deep (greater than 20%) air space. Thirty one @entity0 were considered unsuitable for @entity2 because of complicating disease. Sixty nine @entity0 were treated by @entity2 , and in 45 of these reexpansion was sufficient for the case to be managed as shallow pneumothorax while the @entity0 remained ambulant. The average initial @entity2 from the 69 @entity0 was 1 X 1 litres. The intrapleural pressure was subatmospheric in only 22 (49%) of the 45 successfully aspirated @entity0 . A chest radiograph several hours after @entity2 is the principal control required for this treatment. The recurrence rate was 11.1%. Of 95 @entity0 with a shallow pneumothorax, 3 were intubated for progressive @entity1 and the remainder were encouraged to lead a normal life. The recurrence rate was 11.6%. Retrospectively, it was concluded that 137 @entity0 (70%) had a closed pneumothorax at diagnosis. Primary intubation of all @entity0 with a deep pneumothorax would have represented overtreatment.

title: A place for XXXX in the treatment of spontaneous pneumothorax.

answer: @entity2


abstract: HISTORY: We report on a 82 year-old male who presented with @entity9 in the right upper abdomen, @entity5 and vomitus. An uncomplicated laparoscopic cholecystectomy occurred eight years and a @entity4 60 years before. Clinical examination showed a normal abdominal status without palpable liver, spleen, enlarged lymph nodes or masses. He had no icteric skin and sclera. INVESTIGATIONS: The @entity0 was afebrile without @entity6 . The @entity1 markers @entity8 , CA 19 - 9 and AFP were negative. Ultrasound of the abdomen showed a normal homogeneous echotexture of the liver without signs of @entity10 or @entity3 . In segment 6 a 3 cm large hypoechoic @entity12 with a central echogenic structure with acoustic shadowing was noted. Magnetic resonance revealed a 2.8 x 3.6 cm large lesion in the dorsal region of segment 6 of the liver, infiltrating the perihepatic fat. Pathologic lymph nodes and metastases were not found. DIAGNOSIS AND TREATMENT: At laparotomy, the @entity1 appeared to be malignant with invasion to the perirenal fat. Complete resection with negative margins included segment 6 of the liver and the adjacent fat (the kidney itself was not infiltrated). The cut specimen also showed signs of @entity1 with central @entity2 . However, histology of the resected specimen revealed a sterile @entity11 without @entity1 , but with microscopic foreign bodies. The @entity0 had an uneventful recovery without postoperative complications. CONCLUSIONS: This case report demonstrates the difficulty encountered in the differential diagnosis of inflammatory processes and @entity1 . Chronic inflammatory changes may mimic solid @entity1 . Despite adequate magnetic resonance imaging and thorough intraoperative examination, the correct diagnosis was finally found by histology. The most likely genesis of the @entity7 are lost gallstones during cholecystectomy.

title: [Mimicry of a XXXX as hepatocellular carcinoma].

answer: @entity11


abstract: Dutch workers have proposed that @entity0 with @entity2 and those smokers who develop chronic @entity4 share a common allergic constitution. To study whether smoking itself is associated with indicators of @entity3 , we have examined 237 @entity0 aged 51-61 years (120 smokers, 73 ex-smokers, and 44 non-smokers) who were recruited to a long term study of lung function in 1974, at which time @entity0 with a clinical diagnosis of @entity2 were excluded. Smokers, ex-smokers, and non-smokers did not differ in personal or family history of @entity1 , but the prevalence of positive responses to skinprick tests was greater in ex-smokers (59%) than in the other two groups (33% and 34%). In @entity0 with negative responses to skinprick tests total serum IgE was greater in smokers (log10 mean 1.41 IU/ml) and in ex-smokers (log10 mean 1.53 IU/ml) than in non-smokers (log10 mean 1.12 IU/ml). In @entity0 with positive skin test responses serum IgE was similar in the three groups (log10 mean ranging from 1.68 to 1.78 IU/ml). Geometric mean total white cell counts in the peripheral blood were higher in smokers (7.34 X 10(9)/l) than in non-smokers (5.82 X 10(9)/l); the value in ex-smokers (6.16 X 10(9)/l) was intermediate. Absolute blood eosinophil counts were increased in smokers disproportionately to the increase in total white cell count. Thus smoking is associated with small increases in some markers of @entity3 . These changes are probably acquired after the onset of smoking but sequential studies are required to amplify these cross sectional observations. Smokers whose skin test responses are positive appear more likely to give up smoking.

title: Smoking, XXXX , and the differential white blood cell count.

answer: @entity3


abstract: Kn @entity0 with @entity8 , episodes of transient @entity4 ( @entity4 ) are often documented in addition to the typical episodes of @entity6 @entity6 ( @entity6 ). As the interpretation of these minor ECG changes is still uncertain, we investigated if transient @entity4 are associated with reversible @entity1 , similar to episodes with @entity6 . For this purpose an ECG lead and a two-dimensional echocardiographic projection, which showed clear-cut changes during previous episodes of @entity6 , were simultaneously monitored in five @entity0 with @entity8 for a total of 13 hours and 20 minutes. In all @entity0 , the 30 episodes of @entity6 recorded were all accompanied by reversible @entity1 . Furthermore, in four of these @entity0 , 14 episodes of @entity4 (peaking, flattening, or the appearance of a diphasic T wave) were recorded. All @entity4 were associated with reversible asynergies, as detected by three independent observers. The @entity2 occurred in the same ventricular wall both during @entity6 and during @entity4 . During @entity4 the degree of @entity2 appeared less severe ( @entity7 in 12 and @entity5 in two episodes) than during @entity6 ( @entity7 in one, @entity5 in 25, and @entity5 in four episodes) (p less than 0.001). The duration of asynergies was less during @entity4 (107 +/- 76 seconds) than during @entity6 (169 +/- 83 seconds) (p less than 0.05). @entity3 was reported in 5 of 14 episodes of @entity4 (36%) and in 20 of 30 (66%) episodes of @entity6 (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Transient myocardial ischemia with minimal electrocardiographic changes: an echocardiographic study in @entity0 with XXXX .

answer: @entity8


abstract: Kn @entity0 with @entity8 , episodes of transient @entity4 ( @entity4 ) are often documented in addition to the typical episodes of @entity6 @entity6 ( @entity6 ). As the interpretation of these minor ECG changes is still uncertain, we investigated if transient @entity4 are associated with reversible @entity1 , similar to episodes with @entity6 . For this purpose an ECG lead and a two-dimensional echocardiographic projection, which showed clear-cut changes during previous episodes of @entity6 , were simultaneously monitored in five @entity0 with @entity8 for a total of 13 hours and 20 minutes. In all @entity0 , the 30 episodes of @entity6 recorded were all accompanied by reversible @entity1 . Furthermore, in four of these @entity0 , 14 episodes of @entity4 (peaking, flattening, or the appearance of a diphasic T wave) were recorded. All @entity4 were associated with reversible asynergies, as detected by three independent observers. The @entity2 occurred in the same ventricular wall both during @entity6 and during @entity4 . During @entity4 the degree of @entity2 appeared less severe ( @entity7 in 12 and @entity5 in two episodes) than during @entity6 ( @entity7 in one, @entity5 in 25, and @entity5 in four episodes) (p less than 0.001). The duration of asynergies was less during @entity4 (107 +/- 76 seconds) than during @entity6 (169 +/- 83 seconds) (p less than 0.05). @entity3 was reported in 5 of 14 episodes of @entity4 (36%) and in 20 of 30 (66%) episodes of @entity6 (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Transient myocardial ischemia with minimal electrocardiographic changes: an echocardiographic study in XXXX with @entity8 .

answer: @entity0


abstract: @entity5 was initially prescribed at a dose of 200 mg twice daily, but after early @entity1 in @entity0 with @entity3 ( @entity3 ), the dosage was reduced to 100 mg twice daily. The effects of @entity5 were studied in 40 @entity0 (29 @entity0 and 11 @entity0 , mean age 62 +/- 2 years, ejection fraction 45 +/- 3%) who underwent programmed electrical stimulation to determine the efficacy of @entity5 in preventing @entity3 chronically at the reduced dose. @entity3 was induced in 21 @entity0 and nonsustained @entity3 in 19. @entity5 prevented @entity3 induction in 26 @entity0 (65%). At a mean dose of 1.5 +/- 0.1 mg/kg, prolongation occurred in the effective refractory period of the first (280 +/- 5 vs 249 +/- 5 ms) and second (254 +/- 6 vs 209 +/- 9 ms) extrastimuli (p less than 0.01). In the @entity0 protected by @entity5 , the effective refractory periods increased by a 17 +/- 2% and 21 +/- 3%, in contrast to only a 7 +/- 3% and 6 +/- 4% increase in the nonprotected group (p less than 0.05), despite a higher mean dose (1.9 +/- 0.1 vs 1.35 +/- 0.1 mg/kg). Twenty-one @entity0 were discharged on @entity5 therapy, 100 mg twice daily, and were followed for a mean of 11 months. Sixteen @entity0 are alive and well, 1 died suddenly, 1 died from a noncardiac cause and 1 had a "breakthrough" @entity2 . Two were switched to @entity4 therapy by their referring physicians, but were without problems while receiving @entity5 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX : long-term treatment using a reduced dosing schedule.

answer: @entity5


abstract: Endogenous membrane and cytosolic and nuclear protein phosphorylations were compared among three well-characterized subpopulations of @entity0 @entity2 cells that were originally isolated from a single @entity0 primary @entity2 . These intratumoral subpopulations of cells were found to differ significantly in their biological properties. Analysis of phosphoproteins by two-dimensional electrophoresis following 32P phosphorylation of subcellular fractions in a cell-free system or labeling intact cells in vivo revealed significant differences in the selective phosphorylation of membrane, cytosol, and nuclear proteins. The two-dimensional membrane, cytosol, and nuclear phosphoprotein profiles distinguished the three subpopulations of @entity2 cells from each other. @entity1 -staining proteins from the three subpopulations were also compared. The two-dimensional, @entity1 -stained electrophoretic profiles of nuclear proteins were essentially the same for all three subpopulations. The @entity1 -stained electrophoretic profile of membrane and cytosolic proteins revealed only minor differences in the expression of polypeptides. Nevertheless, these changes could also distinguish the three subpopulations. The results of this study suggest that minor differences in the expression of cytosolic and membrane proteins exist in intratumoral subpopulations of colonic cells. However, a significantly greater degree of heterogeneity was found to be associated with post-translational modification of proteins by phosphorylation and/or dephosphorylation. These modifications could play an important role in determining the expression of different biological properties among subpopulations of malignant cells.

title: Selective protein phosphorylation in heterogeneous subpopulations of @entity0 XXXX cells.

answer: @entity2


abstract: Endogenous membrane and cytosolic and nuclear protein phosphorylations were compared among three well-characterized subpopulations of @entity0 @entity2 cells that were originally isolated from a single @entity0 primary @entity2 . These intratumoral subpopulations of cells were found to differ significantly in their biological properties. Analysis of phosphoproteins by two-dimensional electrophoresis following 32P phosphorylation of subcellular fractions in a cell-free system or labeling intact cells in vivo revealed significant differences in the selective phosphorylation of membrane, cytosol, and nuclear proteins. The two-dimensional membrane, cytosol, and nuclear phosphoprotein profiles distinguished the three subpopulations of @entity2 cells from each other. @entity1 -staining proteins from the three subpopulations were also compared. The two-dimensional, @entity1 -stained electrophoretic profiles of nuclear proteins were essentially the same for all three subpopulations. The @entity1 -stained electrophoretic profile of membrane and cytosolic proteins revealed only minor differences in the expression of polypeptides. Nevertheless, these changes could also distinguish the three subpopulations. The results of this study suggest that minor differences in the expression of cytosolic and membrane proteins exist in intratumoral subpopulations of colonic cells. However, a significantly greater degree of heterogeneity was found to be associated with post-translational modification of proteins by phosphorylation and/or dephosphorylation. These modifications could play an important role in determining the expression of different biological properties among subpopulations of malignant cells.

title: Selective protein phosphorylation in heterogeneous subpopulations of XXXX @entity2 cells.

answer: @entity0


abstract: In order to learn about the immunopathogenic mechanisms of experimental autoimmune @entity3 (EAU), the capacity of lymphocytes to transfer the disease was studied. EAU was transferred to naive syngeneic @entity0 by intraperitoneal injection of spleen or @entity1 ( @entity1 ) cells from @entity4 immunized @entity0 , following their incubation in culture with either @entity4 or concanavalin A (Con A). In contrast, the same cells did not cause inflammatory changes in the recipient eyes when injected intravitreally. The identity of the lymphocytes that transfer EAU was determined by using monoclonal antibody enriched subsets of lymphocytes. EAU was transferred by the subset of helper/inducer T-cells, but not by T-cells of the suppressor/cytotoxic subset. Recipient @entity0 of spleen or @entity1 cells cultured with @entity4 exhibited both humoral and cellular immune responses to @entity4 . On the other hand, recipients of spleen cells cultured with Con A developed only cellular immune response to @entity4 . Yet, both groups of recipients fully developed EAU. The clinical and histologic changes in recipient @entity0 closely resembled those in @entity0 in which EAU was induced by active immunization. Severe @entity2 occurred at the photoreceptor cell layer, but inflammatory infiltration also was found in other ocular tissues. Involvement of polymorphonuclear leukocytes (PMNs) was noted throughout ocular tissues even in the eyes of recipients with no detectable antibodies to @entity4 , suggesting that the ocular PMNs infiltration in @entity0 is not necessarily the result of an Arthus-like inflammatory process.

title: Adoptive transfer of experimental autoimmune XXXX in @entity0 . Immunopathogenic mechanisms and histologic features.

answer: @entity3


abstract: In order to learn about the immunopathogenic mechanisms of experimental autoimmune @entity3 (EAU), the capacity of lymphocytes to transfer the disease was studied. EAU was transferred to naive syngeneic @entity0 by intraperitoneal injection of spleen or @entity1 ( @entity1 ) cells from @entity4 immunized @entity0 , following their incubation in culture with either @entity4 or concanavalin A (Con A). In contrast, the same cells did not cause inflammatory changes in the recipient eyes when injected intravitreally. The identity of the lymphocytes that transfer EAU was determined by using monoclonal antibody enriched subsets of lymphocytes. EAU was transferred by the subset of helper/inducer T-cells, but not by T-cells of the suppressor/cytotoxic subset. Recipient @entity0 of spleen or @entity1 cells cultured with @entity4 exhibited both humoral and cellular immune responses to @entity4 . On the other hand, recipients of spleen cells cultured with Con A developed only cellular immune response to @entity4 . Yet, both groups of recipients fully developed EAU. The clinical and histologic changes in recipient @entity0 closely resembled those in @entity0 in which EAU was induced by active immunization. Severe @entity2 occurred at the photoreceptor cell layer, but inflammatory infiltration also was found in other ocular tissues. Involvement of polymorphonuclear leukocytes (PMNs) was noted throughout ocular tissues even in the eyes of recipients with no detectable antibodies to @entity4 , suggesting that the ocular PMNs infiltration in @entity0 is not necessarily the result of an Arthus-like inflammatory process.

title: Adoptive transfer of experimental autoimmune @entity3 in XXXX . Immunopathogenic mechanisms and histologic features.

answer: @entity0


abstract: Cleavage of @entity5 by @entity6 was studied. Four primary products were detected and separated by high performance liquid chromatography. Two of the fragments are fluorescent and therefore contain residue 23 ( @entity3 ). These fragments are @entity4 -terminal in origin. The other two cross-react with antisera directed against @entity2 -terminal portions of the hormone; they are the complementary @entity2 -terminal fragments. Microsequencing and @entity1 analysis showed that the two @entity2 -terminal fragments are 35-84 and 38-84 @entity0 @entity5 . By CNBr cleavage and @entity1 analysis, the two @entity4 -terminal fragments were shown to be the complementary 1-37 and 1-34 fragments. The 1-37 fragment is transitory and is rapidly hydrolyzed to 1-34, so that only relatively small amounts are detected at any one time. However, 34-84 was not converted to 38-84, although cleavage at other sites in the @entity2 -terminal fragments was observed with more exhaustive digestion. The 1-34 fragment appears to be the final product of the action of @entity6 on @entity5 . Both enzymatically produced @entity4 -terminal fragments were fully active in the renal membrane adenylyl cyclase assay system.

title: Characterization of XXXX fragments produced by @entity6 .

answer: @entity5


abstract: Cleavage of @entity5 by @entity6 was studied. Four primary products were detected and separated by high performance liquid chromatography. Two of the fragments are fluorescent and therefore contain residue 23 ( @entity3 ). These fragments are @entity4 -terminal in origin. The other two cross-react with antisera directed against @entity2 -terminal portions of the hormone; they are the complementary @entity2 -terminal fragments. Microsequencing and @entity1 analysis showed that the two @entity2 -terminal fragments are 35-84 and 38-84 @entity0 @entity5 . By CNBr cleavage and @entity1 analysis, the two @entity4 -terminal fragments were shown to be the complementary 1-37 and 1-34 fragments. The 1-37 fragment is transitory and is rapidly hydrolyzed to 1-34, so that only relatively small amounts are detected at any one time. However, 34-84 was not converted to 38-84, although cleavage at other sites in the @entity2 -terminal fragments was observed with more exhaustive digestion. The 1-34 fragment appears to be the final product of the action of @entity6 on @entity5 . Both enzymatically produced @entity4 -terminal fragments were fully active in the renal membrane adenylyl cyclase assay system.

title: Characterization of @entity5 fragments produced by XXXX .

answer: @entity6


abstract: Forty @entity0 with forty-four unicompartmental @entity4 metallic uncemented hemiarthroplasties were followed for five to thirteen years (average, eight years). Thirty-nine knees had a medial and five, a lateral arthroplasty. The age at surgery ranged from thirty-two to eight-two years (average, sixty-seven years). At the final follow-up, 70 per cent of the knees were rated as good or excellent. Seventy-nine per cent of the knees in @entity0 who were less than sixty-five years old at the time of surgery were in these categories. Six knees (14 per cent) had required revision to either a unicompartmental or a bicompartmental total knee replacement. The average preoperative and postoperative knee flexion did not change, but knees with initially poor motion improved. The average preoperative flexion contracture of 10 degrees improved postoperatively to 5 degrees. Complications were rare and no cases of @entity1 , or clinically detectable @entity3 occurred. Obesity did not seem to adversely affect the outcome. This study indicated that the @entity4 unicompartmental metallic hemiarthroplasty can provide an attractive alternative in the treatment of @entity2 when proximal tibial osteotomy is contraindicated or has failed or when the @entity0 is too young, heavy, or active to consider total knee replacement.

title: XXXX metallic hemiarthroplasty of the knee in @entity2 . Long-term clinical follow-up and current indications.

answer: @entity4


abstract: Forty @entity0 with forty-four unicompartmental @entity4 metallic uncemented hemiarthroplasties were followed for five to thirteen years (average, eight years). Thirty-nine knees had a medial and five, a lateral arthroplasty. The age at surgery ranged from thirty-two to eight-two years (average, sixty-seven years). At the final follow-up, 70 per cent of the knees were rated as good or excellent. Seventy-nine per cent of the knees in @entity0 who were less than sixty-five years old at the time of surgery were in these categories. Six knees (14 per cent) had required revision to either a unicompartmental or a bicompartmental total knee replacement. The average preoperative and postoperative knee flexion did not change, but knees with initially poor motion improved. The average preoperative flexion contracture of 10 degrees improved postoperatively to 5 degrees. Complications were rare and no cases of @entity1 , or clinically detectable @entity3 occurred. Obesity did not seem to adversely affect the outcome. This study indicated that the @entity4 unicompartmental metallic hemiarthroplasty can provide an attractive alternative in the treatment of @entity2 when proximal tibial osteotomy is contraindicated or has failed or when the @entity0 is too young, heavy, or active to consider total knee replacement.

title: @entity4 metallic hemiarthroplasty of the knee in XXXX . Long-term clinical follow-up and current indications.

answer: @entity2


abstract: The clinical efficacy and safety of transvenous cardioversion for termination of sustained @entity5 ( @entity5 ) were examined by a prospective randomized study design in 22 @entity0 (19 @entity0 , three @entity0 ; mean age 64 +/- 9 years) with @entity2 and sustained @entity5 . @entity0 were randomly assigned to undergo an incremental low-energy protocol from 0.03 to 2.2 J (group A, 11 @entity0 ) or an incremental high-energy protocol from 0.5 to 10.0 J (group B, 11 @entity0 ). Transvenous cardioversion was performed during electrophysiologic studies in the control (drug-free) state and during serial antiarrhythmic drug testing in all @entity0 . Both groups were comparable for @entity1 and functional status, and electrophysiologic parameters. A total of 77 episodes of @entity5 (group A, 45; group B, 32) were analyzed. The overall efficacy of transvenous cardioversion for termination of @entity5 was 62% (group A 56% vs group B 72%; p less than .01). Antiarrhythmic drug therapy did not significantly enhance efficacy of transvenous cardioversion (control 59% vs drug 65%; p greater than .2). Stepwise discriminant analysis correlated successful transvenous cardioversion with longer @entity5 cycle length (p less than .0005), higher energy (p less than .025), lower energy waveform tilt (p less than .025), shorter time to initial cardioversion attempt (p less than .025), and shorter QRS duration in sinus rhythm (p less than .05). Acceleration of @entity5 was frequent (8% incidence per @entity7 ). Thirty-one percent of all @entity7 were terminated because of this complication. After cardioversion, transient @entity4 were common ( @entity6 23%, supraventricular @entity3 12%). Displacement of electrode catheters after transvenous cardioversion was uncommon (3%).(ABSTRACT TRUNCATED AT 250 WORDS)

title: A prospective randomized study of the clinical efficacy and safety of transvenous cardioversion for termination of XXXX .

answer: @entity5


abstract: A variety of operations have been proposed for the treatment of radiation injuries of the rectum. In this study, the procedure advocated by the late Sir Alan Parks--resection of the diseased segment down to its points of fixation to the vagina, bladder or prostate; with perianal mucosal stripping of the anorectal segment and primary coloanal (pull-through) @entity7 --was performed in 11 @entity0 . In two others, an attempt at colorectal @entity7 was abandoned because of extreme scarring in the pelvis. The procedures were done following definitive treatment of @entity5 (seven @entity0 ), @entity6 (two @entity0 ), @entity6 (one @entity0 ), @entity2 (one @entity0 ), @entity11 (one @entity0 ), and @entity3 (one @entity0 ). One @entity0 died from a @entity9 on the seventh postoperative day. Of the survivors with a coloanal @entity7 , all had successful closure of their temporary colostomies with follow-up from one to six years. In eight, continence was assessed as being good or excellent. Four @entity0 required anastomotic dilation and another required a surgical procedure for anastomotic stricture. There was one instance each of reoperation for @entity1 . There were no instances of recurrence of @entity10 , @entity8 , perineal @entity4 or tenesmus. The Parks procedure obviates the need for a difficult dissection of the lower rectum and separation of tissues damaged by radiation and avoids the need for eversion techniques. Its selective use is advocated for @entity0 suffering from severe radiation injuries of the rectum.

title: Parks' coloanal pull-through XXXX for severe, complicated radiation proctitis.

answer: @entity7


abstract: The clinicopathological details of eight cases of @entity1 complicated by @entity4 are described. There was a total of 14 primary @entity4 , six of which were not detected before pathological examination of the resection specimens. The reason for this may be related to atypical @entity0 growth patterns. Three occurred in flat mucosa, one in a @entity6 , and another in @entity8 . The occurrence, distribution, and morphology of @entity2 were noted in both resection specimens and biopsies taken at varying stages before resection. @entity0 was associated with normal and adjacent @entity9 mucosa of varying grades. The extent and grade of @entity5 were not reliable indicators of @entity0 differentiation or subsequent clinical outcome. Only two @entity0 were poorly differentiated. In five cases a total of 23 mucosal biopsies were taken, all less than 12 months before resection. Three rectal biopsies were graded positive for @entity5 and three colonic biopsies indefinite for @entity5 . The subsequent resection specimens showed both @entity7 changes. Three rectal and 14 colonic biopsies were graded negative for @entity5 despite positive findings in the subsequent resection specimens. This @entity3 is partly attributed to the patchy nature of @entity5 in colitic mucosa. Two cases illustrate the possibility of @entity5 pursuing a rapidly progressive course. The mucosal changes of @entity1 were assessed using a recently introduced and standardised international classification.

title: Large bowel XXXX and carcinoma in @entity1 .

answer: @entity2


abstract: The clinicopathological details of eight cases of @entity1 complicated by @entity4 are described. There was a total of 14 primary @entity4 , six of which were not detected before pathological examination of the resection specimens. The reason for this may be related to atypical @entity0 growth patterns. Three occurred in flat mucosa, one in a @entity6 , and another in @entity8 . The occurrence, distribution, and morphology of @entity2 were noted in both resection specimens and biopsies taken at varying stages before resection. @entity0 was associated with normal and adjacent @entity9 mucosa of varying grades. The extent and grade of @entity5 were not reliable indicators of @entity0 differentiation or subsequent clinical outcome. Only two @entity0 were poorly differentiated. In five cases a total of 23 mucosal biopsies were taken, all less than 12 months before resection. Three rectal biopsies were graded positive for @entity5 and three colonic biopsies indefinite for @entity5 . The subsequent resection specimens showed both @entity7 changes. Three rectal and 14 colonic biopsies were graded negative for @entity5 despite positive findings in the subsequent resection specimens. This @entity3 is partly attributed to the patchy nature of @entity5 in colitic mucosa. Two cases illustrate the possibility of @entity5 pursuing a rapidly progressive course. The mucosal changes of @entity1 were assessed using a recently introduced and standardised international classification.

title: Large bowel @entity2 and carcinoma in XXXX .

answer: @entity1


abstract: Selective modification of atrioventricular (AV) nodal conduction, that is, induction of varying degrees of AV @entity1 (second or third degree), or both, was achieved with a pervenous laser catheter technique. In six adult mongrel @entity0 anesthetized with @entity4 (Nembutal), 5F leads were placed through femoral and external jugular veins and placed into the right atrium and His bundle region. Through another femoral vein, a 200 micron optical fiber was inserted by way of a 7F catheter with a preformed curved tip. Guided by fluoroscopy and His bundle electrograms, the fiber's tip was positioned in the AV nodal region. After autonomic blockade was achieved with intravenous @entity2 (5 mg) and @entity3 (1 mg), AV conduction was analyzed. An argon laser delivered 3 to 4 watts into the fiber in bursts of 10 seconds' duration until the desired degree of AV nodal delay or block (second or third degree) was manifested. Monitoring of His bundle electrograms was continued for 2 hours. Four weekly serial electrocardiograms were recorded, after which electrophysiologic studies were repeated. Acute post-lasing studies showed that: in all six @entity0 , the mean PR interval was prolonged from 116 ms (range 100 to 135) to 153 ms (range 120 to 185), with the prolongation being caused exclusively by AH lengthening from 68 ms (range 50 to 90) to 105 ms (range 65 to 140); the mean effective refractory period of the AV node increased from less than 185 ms (range less than 150 to less than 200) to 215 ms (range 190 to 280); and the mean atrial pacing cycle length, at which second degree AV @entity1 was manifested, increased from 210 ms (range 160 to 260) to 261 ms (range 205 to 320).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Laser catheter-induced atrioventricular nodal delays and atrioventricular block in XXXX : acute and chronic observations.

answer: @entity0


abstract: We reviewed the records of 251 @entity0 whose cases were diagnosed between 1958 and 1978 at the @entity0 's Hospital Medical Center Special Treatment Center for @entity5 . We used a computerized system that included retrieval of data on range of motion, @entity3 , @entity1 , functional capacity, and radiographic changes at each six-month visit over the years that the @entity0 was followed. For the @entity0 who were operated on, the radiographic information was evaluated preoperatively and at the last radiographic follow-up (average, six years after operation). The data bank contained postoperative radiographic information for thirty-two of the joints that had been operated on. We reviewed the late results of forty-one synovectomies in thirty @entity0 . The data included range of motion, swelling, and @entity3 before operation, at one and two years after operation, and at an average of 7.1 years of follow-up. There were few if any benefits from the operation with reference to @entity3 or improvement of range of motion, but it did seem to provide permanent relief of the @entity1 . Furthermore, radiographic deterioration seemed to continue in the joints that had been operated on if they already had radiographic changes at the time of operation (late synovectomy). In the joints without radiographic changes at the time of operation (early synovectomy), there seemed to be a continuation of deterioration in those affected by @entity2 , while the changes were less pronounced in those affected by @entity2 . We undertook this study with a positive attitude toward synovectomy in the treatment of @entity4 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Late results of synovectomy in XXXX .

answer: @entity4


abstract: When large soft-tissue and @entity4 remain after d  bridement of a chronic @entity1 , application of a local muscle flap can be an effective way to achieve wound closure. Utilizing this surgical technique and specific antimicrobial therapy for the causal microorganisms, the infectious process was eradicated in thirty-nine of forty-two @entity0 with @entity7 who were followed for at least two years after treatment. The osteomyelitic process was post-traumatic in origin--that is, a complication of a @entity5 or its treatment--in twenty-eight @entity0 , the result of soft-tissue @entity3 without a @entity5 in eight, a complication of elective surgery in three, and the result of hematogenous seeding in three @entity0 . Nine of the forty-two @entity0 had an infected non-union. The infectious process involved the tibia in 62 per cent of the @entity0 . @entity6 was the most frequently isolated causal organism. A soleus or gastrocnemius muscle flap was most frequently utilized to achieve closure. In five @entity0 , a combination of two muscle flaps was utilized. Although this technique successfully eradicated the infectious process in 93 per cent of the @entity0 , twenty-two @entity0 required additional surgical treatment. Six required such treatment for a persistent non-union and two, for weakened diaphyseal bone after eradication of the septic process. A cancellous bone-grafting procedure was performed in all eight @entity0 after the muscle flap had healed, and union was achieved in six of them. One @entity0 eventually requested an amputation for a persistent non-union, and the remaining @entity0 had a fibular @entity9 performed for a persistent tibial non-union. A local muscle flap can be used in @entity0 with a large defect of soft tissue and bone after d  bridement of an @entity1 if the flap can be elevated and transposed into the defect without compromising its vascular supply. Although they are not applicable to the treatment of all @entity0 with @entity7 , @entity2 can be extremely useful in the treatment of this lesion. When combined with thorough d  bridement and specific antimicrobial therapy, it has become a successful technique in the management of @entity8 .

title: Local muscle flaps in the treatment of XXXX .

answer: @entity8


abstract: Recent evidence demonstrates that coagulation plays a role in mediating @entity1 in @entity0 with @entity5 and @entity3 . Because of its beneficial effect in experimental @entity3 , we treated @entity0 with @entity5 and @entity3 with ancrod, a drug known to lower fibrinogen levels and thought to activate fibrinolysis. Our @entity0 had unusually severe @entity1 ; renal function was deteriorating in many. Before ancrod, vascular plasminogen activator levels were low, and levels of an inhibitor of plasminogen activation were elevated. Some @entity0 had elevated @entity6 inhibitor levels. Results were considered in two groups. In 13 @entity0 characterized as fibrinolysis responders, the low vascular plasminogen activator and increased plasminogen activation inhibitor levels normalized. After ancrod, striking resolution of microvascular @entity4 occurred, which was associated with some improvement in renal function and blood pressure control. In five @entity0 characterized as fibrinolysis nonresponders and who also had an elevated @entity6 inhibitor (alpha 2-antiplasmin) level, normalization of fibrinolysis did not occur. There was little change in microvascular @entity4 , renal function, or blood pressure control in the fibrinolysis nonresponders. These preliminary observations demonstrate a @entity2 in @entity0 with @entity5 with microvascular thrombi in the kidney. Ancrod therapy reverses this disorder rapidly in @entity0 with a normal level of @entity6 inhibitor and may lead to repair of @entity1 .

title: Lupus nephritis with XXXX and abnormal fibrinolysis: effect of ancrod.

answer: @entity4


abstract: Young hypophysectomized @entity1 were maintained with chronic indwelling i.v. cannulae attached via swivels to a multichannel pumping system programmed to deliver GH in a continuous or pulsatile pattern for several days. Continuous i.v. infusions of @entity0 GH for 5 days produced dose-dependent increases in body weight and tail length, without increasing food intake. A comparison of GH infusions by the s.c. or i.v. route showed that the direct i.v. route was threefold more effective. Pulsatile i.v. infusions of @entity0 or @entity2 GH at two doses (12 or 36 mu./day, eight pulses/day, 5-min duration, every 3 h) produced greater increases in body weight than continuous i.v. infusions of GH at the same daily dose. Continuous infusions of @entity2 GH produced a lower growth rate in the second of two consecutive 5-day treatment periods, whereas the responses to pulsatile GH did not diminish with time. Both body @entity3 and long-bone growth were affected by the frequency of GH pulses; nine pulses per day were more effective than three pulses per day which in turn produced larger growth responses than one pulse per day. Keeping GH pulse frequency constant and varying pulse duration (4, 16 or 64 min) did not affect growth rates. In conclusion, long-term pulsatile i.v. infusions of GH mimic the endogenous secretory pattern, and are most effective when given at the physiologically appropriate pulse frequency.

title: Intravenous growth hormone: growth responses to patterned infusions in hypophysectomized XXXX .

answer: @entity1


abstract: Left ventricular contractility following induction of experimental @entity3 (EP) was studied. Contractility was evaluated by analyzing the left ventricular end systolic pressure-diameter relationship (sigma ES). Sigma ES is independent of large changes in preload, afterload, and heart rate, but sensitive to changes in ventricular contractility. Following injection of 100,000 IU trypsin in 4% @entity4 into the pancreas to induce EP, seven of eight @entity2 survived 5 hr. These @entity2 exhibited an initial significant reduction in mean arterial pressure (MABP) which stabilized at 90% of control at 3-5 hr post-EP. Cardiac output (CO) dropped slowly after EP induction (from 3.08 +/- 0.43 to 2.22 +/- 0.22 liters/min) associated with no significant change in peripheral resistance. @entity0 work and @entity0 volume were markedly depressed reflecting the changes in MABP and CO. No consistent changes in +dP/dt or -dP/dt were observed. The ratio of endo/epicardial blood flow was unchanged as was blood @entity1 levels throughout the experiment. Ventricular contractility as reflected by sigma ES tended to improve (from 49.7 to 69.6 mm Hg/mm at 4 hr following EP). Therefore, it was concluded that these animals exhibited no loss of ventricular contractility during EP.

title: @entity2 left ventricular function during experimental XXXX .

answer: @entity3


abstract: Left ventricular contractility following induction of experimental @entity3 (EP) was studied. Contractility was evaluated by analyzing the left ventricular end systolic pressure-diameter relationship (sigma ES). Sigma ES is independent of large changes in preload, afterload, and heart rate, but sensitive to changes in ventricular contractility. Following injection of 100,000 IU trypsin in 4% @entity4 into the pancreas to induce EP, seven of eight @entity2 survived 5 hr. These @entity2 exhibited an initial significant reduction in mean arterial pressure (MABP) which stabilized at 90% of control at 3-5 hr post-EP. Cardiac output (CO) dropped slowly after EP induction (from 3.08 +/- 0.43 to 2.22 +/- 0.22 liters/min) associated with no significant change in peripheral resistance. @entity0 work and @entity0 volume were markedly depressed reflecting the changes in MABP and CO. No consistent changes in +dP/dt or -dP/dt were observed. The ratio of endo/epicardial blood flow was unchanged as was blood @entity1 levels throughout the experiment. Ventricular contractility as reflected by sigma ES tended to improve (from 49.7 to 69.6 mm Hg/mm at 4 hr following EP). Therefore, it was concluded that these animals exhibited no loss of ventricular contractility during EP.

title: XXXX left ventricular function during experimental @entity3 .

answer: @entity2


abstract: Evaluation of the aortic root in 13 @entity0 with @entity1 aged 2.5 to 24 years (mean 8.3 years) has revealed morphologic characteristics of asymmetry of the aortic root caused by a small (hypoplastic) left sinus of Valsalva associated with a supravalvular ridge above the left coronary ostium and @entity2 of the aortic valve. The asymmetry resulted in folding and buckling of the left aortic cusp. The aortic valve was classified as bicuspid in 11 of the 13 @entity0 . Preoperative aortography was characteristic and revealed the diagnosis in all @entity0 . The average left ventricle-aorta systolic pressure gradient was 81 mm Hg. Operative repair consisted of an oblique aortotomy extended in a spiral fashion to the right and posteriorly into the left sinus of Valsalva. Seven @entity0 had further mobilization of the posterior commissure with a second incision to the right of the commissure into the noncoronary sinus. Slightly fused valve commissures were opened in 12 @entity0 . Aortic root reconstruction was accomplished with a spiral Dacron patch and posterior commissural repositioning. Follow-up catheterization at 9 to 35 months (mean 24 months) in five @entity0 demonstrated an average outflow tract systolic gradient of 28 mm Hg and a more symmetrical appearance of the aortic root.

title: XXXX with hypoplasia of the left sinus of Valsalva. Anatomic reconstruction of the aortic root.

answer: @entity1


abstract: An 8-week program taught nutrition and aerobic exercise to @entity1 , @entity4 mothers of @entity0 under 3 years. A reduction in risk factors for @entity2 in the mothers was anticipated. Culturally adapted aerobic dancing was well-suited for exercise. It was assumed that @entity0 would ultimately adopt their parents' changed life style. The program demonstrated a significant reduction in heart rates at rest, but no significant change in heart rates with stress. A significant reduction in body-fat percentage was measured, whereas overall weight reduction was not significant. The consumption of @entity6 , protein, fat, and @entity8 was reduced. Intake of @entity5 , @entity3 , @entity9 , and @entity7 rose significantly. The results indicate the potential effectiveness of such dual intervention programs. Further study would be necessary for more conclusive results and recommendations.

title: A nutrition-physical fitness intervention program for XXXX parents.

answer: @entity4


abstract: The histories of 22 @entity0 presenting during the first year of life with @entity8 due to @entity4 were analyzed to determine outcome and prognostic features. Mean @entity0 age at the time of the initial surgical intervention was 39 days, and the mean duration of followup inclusive of renal function data was 5.8 years. One @entity0 died (5 per cent) and one had @entity5 . The mean preoperative and postoperative serum @entity7 concentrations during the initial hospitalization were 3.1 and 1.4 mg. per dl., respectively. Neither value was significantly predictive of the @entity7 concentration at final followup. In contrast, the nadir @entity7 value during the first year of life correlated significantly with final renal function. @entity0 with nadir @entity7 values less than or equal to 0.8 mg. per dl. by 12 months of age maintained @entity7 levels less than or equal to 1.1 mg. per dl. at the time of final evaluation, whereas @entity0 with higher values during the first year of life were likely to have progressive @entity2 . Of 19 final @entity7 determinations 6 were normal and 5 exceeded 1.5 mg. per dl. @entity6 , @entity1 , renal biopsy findings, @entity3 , unilateral nephrectomy and type of surgery did not correlate significantly with functional outcome. Followup studies of longer duration are needed to determine the ultimate outcome of these @entity0 , more than half of whom had some degree of @entity2 at final evaluation.

title: Prognostic features in @entity0 with @entity8 due to XXXX .

answer: @entity4


abstract: The histories of 22 @entity0 presenting during the first year of life with @entity8 due to @entity4 were analyzed to determine outcome and prognostic features. Mean @entity0 age at the time of the initial surgical intervention was 39 days, and the mean duration of followup inclusive of renal function data was 5.8 years. One @entity0 died (5 per cent) and one had @entity5 . The mean preoperative and postoperative serum @entity7 concentrations during the initial hospitalization were 3.1 and 1.4 mg. per dl., respectively. Neither value was significantly predictive of the @entity7 concentration at final followup. In contrast, the nadir @entity7 value during the first year of life correlated significantly with final renal function. @entity0 with nadir @entity7 values less than or equal to 0.8 mg. per dl. by 12 months of age maintained @entity7 levels less than or equal to 1.1 mg. per dl. at the time of final evaluation, whereas @entity0 with higher values during the first year of life were likely to have progressive @entity2 . Of 19 final @entity7 determinations 6 were normal and 5 exceeded 1.5 mg. per dl. @entity6 , @entity1 , renal biopsy findings, @entity3 , unilateral nephrectomy and type of surgery did not correlate significantly with functional outcome. Followup studies of longer duration are needed to determine the ultimate outcome of these @entity0 , more than half of whom had some degree of @entity2 at final evaluation.

title: Prognostic features in @entity0 with XXXX due to @entity4 .

answer: @entity8


abstract: The histories of 22 @entity0 presenting during the first year of life with @entity8 due to @entity4 were analyzed to determine outcome and prognostic features. Mean @entity0 age at the time of the initial surgical intervention was 39 days, and the mean duration of followup inclusive of renal function data was 5.8 years. One @entity0 died (5 per cent) and one had @entity5 . The mean preoperative and postoperative serum @entity7 concentrations during the initial hospitalization were 3.1 and 1.4 mg. per dl., respectively. Neither value was significantly predictive of the @entity7 concentration at final followup. In contrast, the nadir @entity7 value during the first year of life correlated significantly with final renal function. @entity0 with nadir @entity7 values less than or equal to 0.8 mg. per dl. by 12 months of age maintained @entity7 levels less than or equal to 1.1 mg. per dl. at the time of final evaluation, whereas @entity0 with higher values during the first year of life were likely to have progressive @entity2 . Of 19 final @entity7 determinations 6 were normal and 5 exceeded 1.5 mg. per dl. @entity6 , @entity1 , renal biopsy findings, @entity3 , unilateral nephrectomy and type of surgery did not correlate significantly with functional outcome. Followup studies of longer duration are needed to determine the ultimate outcome of these @entity0 , more than half of whom had some degree of @entity2 at final evaluation.

title: Prognostic features in XXXX with @entity8 due to @entity4 .

answer: @entity0


abstract: UNASSIGNED: @entity5 of @entity6 is one the highest number of @entity1 seen in the Southeast Asian region. It is related to chewing a combination of @entity3 mixed with betel leaves, areca nut, and lime shell called quid. As it is most commonly due to @entity4 and affects younger population, it has tremendous economical and social consequences. Surgery is the most successful modality of management in these @entity0 . The surgery involves wide excision of the diseased mucosa and neck dissection. Neck dissection is associated with certain morbidities, but is routinely practiced in some centers like ours. We have attempted to evaluate the occurrence of the @entity2 in relation to the thickness of the @entity1 in cases of early @entity1 (stage I and II). We have used ultrasound of the lesion as our modality to assess the @entity1 thickness preoperatively. AJCC 7th edition was used to assess the clinical and pathological stage of the disease. We have studied 52 @entity0 of early buccal @entity5 , and we observed that @entity1 thicker than 7mm (p-0.05) have highest co-relation with nodal metastases. This study also recommends that neck dissection should be prophylactically performed for @entity1 thicker than 4mm. Tumor characteristics such as grade, perineural invasion, and lymphatic invasion should be considered as predictors for early nodal involvement.

title: Tumor Thickness: A predictor of @entity2 in early XXXX of @entity6 .

answer: @entity5


abstract: UNASSIGNED: @entity5 of @entity6 is one the highest number of @entity1 seen in the Southeast Asian region. It is related to chewing a combination of @entity3 mixed with betel leaves, areca nut, and lime shell called quid. As it is most commonly due to @entity4 and affects younger population, it has tremendous economical and social consequences. Surgery is the most successful modality of management in these @entity0 . The surgery involves wide excision of the diseased mucosa and neck dissection. Neck dissection is associated with certain morbidities, but is routinely practiced in some centers like ours. We have attempted to evaluate the occurrence of the @entity2 in relation to the thickness of the @entity1 in cases of early @entity1 (stage I and II). We have used ultrasound of the lesion as our modality to assess the @entity1 thickness preoperatively. AJCC 7th edition was used to assess the clinical and pathological stage of the disease. We have studied 52 @entity0 of early buccal @entity5 , and we observed that @entity1 thicker than 7mm (p-0.05) have highest co-relation with nodal metastases. This study also recommends that neck dissection should be prophylactically performed for @entity1 thicker than 4mm. Tumor characteristics such as grade, perineural invasion, and lymphatic invasion should be considered as predictors for early nodal involvement.

title: Tumor Thickness: A predictor of XXXX in early @entity5 of @entity6 .

answer: @entity2


abstract: UNASSIGNED: @entity5 of @entity6 is one the highest number of @entity1 seen in the Southeast Asian region. It is related to chewing a combination of @entity3 mixed with betel leaves, areca nut, and lime shell called quid. As it is most commonly due to @entity4 and affects younger population, it has tremendous economical and social consequences. Surgery is the most successful modality of management in these @entity0 . The surgery involves wide excision of the diseased mucosa and neck dissection. Neck dissection is associated with certain morbidities, but is routinely practiced in some centers like ours. We have attempted to evaluate the occurrence of the @entity2 in relation to the thickness of the @entity1 in cases of early @entity1 (stage I and II). We have used ultrasound of the lesion as our modality to assess the @entity1 thickness preoperatively. AJCC 7th edition was used to assess the clinical and pathological stage of the disease. We have studied 52 @entity0 of early buccal @entity5 , and we observed that @entity1 thicker than 7mm (p-0.05) have highest co-relation with nodal metastases. This study also recommends that neck dissection should be prophylactically performed for @entity1 thicker than 4mm. Tumor characteristics such as grade, perineural invasion, and lymphatic invasion should be considered as predictors for early nodal involvement.

title: Tumor Thickness: A predictor of @entity2 in early @entity5 of XXXX .

answer: @entity6


abstract: OBJECTIVES: The utility of parametrial resection in @entity0 with @entity1 is controversial. In @entity0 with favorable pathologic characteristics such as @entity1 size <2cm and the absence of lymphovascular space invasion, the rate of parametrial involvement is very low. More conservative surgical approaches have therefore been suggested. The objective of this report is to review the existing literature in this area and to describe an ongoing prospective study evaluating the safety and efficacy of conservative surgery in @entity0 with @entity1 . METHODS: We performed a search of PubMed for English language articles published between 1970 and 2010 using the MeSH terms " @entity1 ", "conservative surgery", and "cone biopsy". RESULTS: Several retrospective studies have shown that <1% of @entity0 with @entity1 with favorable pathologic characteristics have parametrial involvement. In addition, approximately 60% of @entity0 undergoing radical trachelectomy have no @entity2 in the final pathologic specimen. Recent studies have reported on the feasibility and safety of performing less radical surgery consisting of pelvic lymphadenectomy with cone biopsy, simple trachelectomy or simple hysterectomy in @entity0 with stage @entity5 to @entity4 @entity3 . In addition, a prospective, multi-center, international trial is currently being performed to evaluate the outcomes of performing pelvic lymphadenectomy with conservative surgery (simple hysterectomy or cervical conization) in @entity0 with favorable pathologic characteristics. Neoadjuvant chemotherapy followed by conservative surgery is also being explored as an option for @entity0 with @entity1 and other pathologic characteristics that do not meet the criteria to perform conservative surgery alone. CONCLUSIONS: The rate of parametrial involvement in @entity0 with @entity1 with favorable pathologic characteristics is low. Should the results of ongoing studies be favorable, conservative surgery could become the standard of care for certain @entity0 with @entity1 .

title: Conservative management of XXXX : is there a role for less radical surgery?

answer: @entity1


abstract: UNASSIGNED: @entity3 and @entity11 are well-known @entity6 . The incidence of lower urinary tract dysfunction (LUTD) in these @entity0 ranges from 14% to 53%, mostly @entity12 ( @entity12 ), and is higher when the frontal cortex is involved. This presumably reflects damage at the prefrontal cortex, cingulate cortex, and other areas that regulate (mainly inhibit) the micturition reflex. @entity2 ( @entity2 ) is a chronic, bilateral form of @entity4 , leading to a high prevalence of @entity12 (up to 90%). Since @entity2 is particularly common in the elderly, @entity2 may be one of the anatomic substrates for elderly @entity12 . @entity7 and normal-pressure @entity10 are rather diffuse @entity6 , which cause @entity12 with a prevalence rate of 60-95%. Recent neuroimaging studies have shown a relationship between LUTD and the frontal cortex in these diseases. Data on other @entity6 , particularly affecting deep @entity6 , are limited. Small @entity9 , @entity1 , or inflammatory diseases affecting the basal ganglia, hypothalamus, and cerebellum lead to mainly @entity12 . In contrast, similar diseases affecting the brainstem lead to either @entity12 or urinary retention. The latter reflects damage at the periaqueductal gray and the pontine micturition center that directly relay and modulate the micturition reflex. @entity8 ( @entity8 ) in @entity6 can be divided into two types: neurogenic @entity8 (due to @entity12 ) and functional @entity8 (immobility and @entity5 ). These two types of @entity8 may occur together, but management differs significantly. Management of neurogenic @entity8 includes anticholinergic drugs that do not penetrate the blood-brain barrier easily. Management of functional @entity8 includes behavioral therapy (timed/prompted voiding with physical assistance and bladder/pelvic floor training) and drugs to treat gait as well as cognition that facilitate continence. These treatments will maximize the quality of life in @entity0 with @entity6 .

title: Lower urinary tract dysfunction in @entity0 with XXXX .

answer: @entity6


abstract: UNASSIGNED: @entity3 and @entity11 are well-known @entity6 . The incidence of lower urinary tract dysfunction (LUTD) in these @entity0 ranges from 14% to 53%, mostly @entity12 ( @entity12 ), and is higher when the frontal cortex is involved. This presumably reflects damage at the prefrontal cortex, cingulate cortex, and other areas that regulate (mainly inhibit) the micturition reflex. @entity2 ( @entity2 ) is a chronic, bilateral form of @entity4 , leading to a high prevalence of @entity12 (up to 90%). Since @entity2 is particularly common in the elderly, @entity2 may be one of the anatomic substrates for elderly @entity12 . @entity7 and normal-pressure @entity10 are rather diffuse @entity6 , which cause @entity12 with a prevalence rate of 60-95%. Recent neuroimaging studies have shown a relationship between LUTD and the frontal cortex in these diseases. Data on other @entity6 , particularly affecting deep @entity6 , are limited. Small @entity9 , @entity1 , or inflammatory diseases affecting the basal ganglia, hypothalamus, and cerebellum lead to mainly @entity12 . In contrast, similar diseases affecting the brainstem lead to either @entity12 or urinary retention. The latter reflects damage at the periaqueductal gray and the pontine micturition center that directly relay and modulate the micturition reflex. @entity8 ( @entity8 ) in @entity6 can be divided into two types: neurogenic @entity8 (due to @entity12 ) and functional @entity8 (immobility and @entity5 ). These two types of @entity8 may occur together, but management differs significantly. Management of neurogenic @entity8 includes anticholinergic drugs that do not penetrate the blood-brain barrier easily. Management of functional @entity8 includes behavioral therapy (timed/prompted voiding with physical assistance and bladder/pelvic floor training) and drugs to treat gait as well as cognition that facilitate continence. These treatments will maximize the quality of life in @entity0 with @entity6 .

title: Lower urinary tract dysfunction in XXXX with @entity6 .

answer: @entity0


abstract: UNASSIGNED: @entity9 ( @entity9 ) is common among @entity0 with @entity7 ( @entity7 ), @entity8 ( @entity8 ), and other @entity10 . Sexual functioning and well-being of @entity0 with @entity7 and their partners are affected by many factors, including motor disabilities, non-motor symptoms (e.g., @entity14 , @entity2 , @entity12 , @entity3 , @entity6 , and @entity4 ), medication effects, and relationship issues. The common sexual problems are decreased desire, @entity11 , difficulties in reaching orgasm, and sexual dissatisfaction. Hypersexuality is one of a broad range of @entity1 reported in @entity7 , attributed to antiparkinsonian therapy, mainly dopamine agonists. Involvement of a multidisciplinary team may enable a significant management of hypersexuality. Data on @entity9 in demented @entity0 are scarce, mainly reporting reduced frequency of sex and @entity11 . Treatment of @entity9 is advised at an early stage. @entity5 , including inappropriate @entity5 (ISB), are distressing for @entity0 and their caregivers and may reflect the prevailing behavior accompanying @entity10 ( @entity13 associated with hyposexuality). The neurobiologic basis of ISB is still only vaguely understood but assessment and intervention are recommended as soon as ISB is suspected. Management of ISB in @entity10 demands a thorough evaluation and understanding of the behavior, and can be treated by non-pharmacologic and pharmacologic interventions.

title: Sexuality in @entity0 with XXXX , @entity8 , and other @entity10 .

answer: @entity7


abstract: UNASSIGNED: @entity9 ( @entity9 ) is common among @entity0 with @entity7 ( @entity7 ), @entity8 ( @entity8 ), and other @entity10 . Sexual functioning and well-being of @entity0 with @entity7 and their partners are affected by many factors, including motor disabilities, non-motor symptoms (e.g., @entity14 , @entity2 , @entity12 , @entity3 , @entity6 , and @entity4 ), medication effects, and relationship issues. The common sexual problems are decreased desire, @entity11 , difficulties in reaching orgasm, and sexual dissatisfaction. Hypersexuality is one of a broad range of @entity1 reported in @entity7 , attributed to antiparkinsonian therapy, mainly dopamine agonists. Involvement of a multidisciplinary team may enable a significant management of hypersexuality. Data on @entity9 in demented @entity0 are scarce, mainly reporting reduced frequency of sex and @entity11 . Treatment of @entity9 is advised at an early stage. @entity5 , including inappropriate @entity5 (ISB), are distressing for @entity0 and their caregivers and may reflect the prevailing behavior accompanying @entity10 ( @entity13 associated with hyposexuality). The neurobiologic basis of ISB is still only vaguely understood but assessment and intervention are recommended as soon as ISB is suspected. Management of ISB in @entity10 demands a thorough evaluation and understanding of the behavior, and can be treated by non-pharmacologic and pharmacologic interventions.

title: Sexuality in @entity0 with @entity7 , XXXX , and other @entity10 .

answer: @entity8


abstract: UNASSIGNED: @entity9 ( @entity9 ) is common among @entity0 with @entity7 ( @entity7 ), @entity8 ( @entity8 ), and other @entity10 . Sexual functioning and well-being of @entity0 with @entity7 and their partners are affected by many factors, including motor disabilities, non-motor symptoms (e.g., @entity14 , @entity2 , @entity12 , @entity3 , @entity6 , and @entity4 ), medication effects, and relationship issues. The common sexual problems are decreased desire, @entity11 , difficulties in reaching orgasm, and sexual dissatisfaction. Hypersexuality is one of a broad range of @entity1 reported in @entity7 , attributed to antiparkinsonian therapy, mainly dopamine agonists. Involvement of a multidisciplinary team may enable a significant management of hypersexuality. Data on @entity9 in demented @entity0 are scarce, mainly reporting reduced frequency of sex and @entity11 . Treatment of @entity9 is advised at an early stage. @entity5 , including inappropriate @entity5 (ISB), are distressing for @entity0 and their caregivers and may reflect the prevailing behavior accompanying @entity10 ( @entity13 associated with hyposexuality). The neurobiologic basis of ISB is still only vaguely understood but assessment and intervention are recommended as soon as ISB is suspected. Management of ISB in @entity10 demands a thorough evaluation and understanding of the behavior, and can be treated by non-pharmacologic and pharmacologic interventions.

title: Sexuality in @entity0 with @entity7 , @entity8 , and other XXXX .

answer: @entity10


abstract: UNASSIGNED: @entity9 ( @entity9 ) is common among @entity0 with @entity7 ( @entity7 ), @entity8 ( @entity8 ), and other @entity10 . Sexual functioning and well-being of @entity0 with @entity7 and their partners are affected by many factors, including motor disabilities, non-motor symptoms (e.g., @entity14 , @entity2 , @entity12 , @entity3 , @entity6 , and @entity4 ), medication effects, and relationship issues. The common sexual problems are decreased desire, @entity11 , difficulties in reaching orgasm, and sexual dissatisfaction. Hypersexuality is one of a broad range of @entity1 reported in @entity7 , attributed to antiparkinsonian therapy, mainly dopamine agonists. Involvement of a multidisciplinary team may enable a significant management of hypersexuality. Data on @entity9 in demented @entity0 are scarce, mainly reporting reduced frequency of sex and @entity11 . Treatment of @entity9 is advised at an early stage. @entity5 , including inappropriate @entity5 (ISB), are distressing for @entity0 and their caregivers and may reflect the prevailing behavior accompanying @entity10 ( @entity13 associated with hyposexuality). The neurobiologic basis of ISB is still only vaguely understood but assessment and intervention are recommended as soon as ISB is suspected. Management of ISB in @entity10 demands a thorough evaluation and understanding of the behavior, and can be treated by non-pharmacologic and pharmacologic interventions.

title: Sexuality in XXXX with @entity7 , @entity8 , and other @entity10 .

answer: @entity0


abstract: PURPOSE: The Multinational Association of Supportive Care in Cancer (MASCC) developed the MASCC antiemesis tool (MAT) as a tool for chemotherapy-induced @entity2 (CINV) assessment and subsequently published its Japanese version in 2010. We evaluated the validity of CINV assessment in outpatients using the Japanese version of MAT. METHODS: @entity0 administered highly or moderately emetogenic chemotherapy in the outpatient chemotherapy unit of our hospital were included in the study. The study was designed as a prospective two-period crossover observational study to evaluate the correlation between the daily @entity0 diary and the Japanese version of MAT in terms of CINV onset. We examined with a focus on reliability of the Japanese version of MAT particularly in the description of the delayed phase of @entity2 . RESULTS: @entity0 descriptions of CINV onset in a total of 116  cycles in 58 @entity0 (two cycles/ @entity0 ) were analyzed. The CINV incidence indicated by the @entity0 diary was similar to that by the Japanese version of MAT. The concordance rate between the two tools in the same @entity0 was 86.2  % for CINV onset in the delayed phase. The @entity1 score was also similar between the two tools regarding the mean and variance, showing a strong correlation with a correlation coefficient of 0.71. CONCLUSIONS: The results of the study showed that the Japanese version of MAT is a highly reliable tool for CINV assessment, indicating that it is valid for assessing CINV in outpatients.

title: Evaluation of the validity of chemotherapy-induced XXXX assessment in outpatients using the Japanese version of the MASCC antiemesis tool.

answer: @entity2


abstract: Medication nonadherence is a significant health care issue requiring regular behavioral treatment. Lack of sufficient health care resources and @entity0 /family time commitment for weekly treatment are primary barriers to receiving appropriate self-management support. We describe the methodology of the Telehealth Enhancement of Adherence to Medication (TEAM) trial for medication nonadherence in pediatric @entity1 ( @entity1 ). For this trial, @entity0 11-18 years of age will be recruited from seven pediatric hospitals and will complete an initial 4-week run in to assess adherence to a daily medication. Those who take less than 90% of their prescribed medication will be randomized. A total of 194 @entity0 with @entity1 will be randomized to either a @entity2 ( @entity2 ) arm or education only (EO) arm. All treatments will be delivered via telehealth video conferencing. The @entity0 will be assessed at baseline, post-treatment, 3, 6, and 12 months. We anticipate that @entity0 in the @entity2 arm will demonstrate a statistically significant improvement at post-treatment and 3-, 6-, and 12-month follow-up compared to @entity0 in the EO arm for both medication adherence and secondary outcomes (i.e., disease severity, @entity0 quality of life, and health care utilization). If efficacious, the TEAM intervention could be disseminated broadly and reduce health care access barriers so that the @entity0 could receive much needed self-management intervention.

title: The Telehealth Enhancement of Adherence to Medication (TEAM) in pediatric XXXX trial: Design and methodology.

answer: @entity1


abstract: UNASSIGNED: Recently, the fascia innervation has become an important issue, particularly the existence of nociceptive fibers. Fascia can be a source of @entity2 in several disorders such as @entity4 and non-specific @entity3 . However, nothing is known about possible changes of the fascia innervation under pathological circumstances. This question is important, because @entity2 from the fascia cannot only be due to increased nociceptor discharges, but also to a denser innervation of the fascia by nociceptive endings. In this histological study, an @entity0 was induced in the thoracolumbar fascia (TLF) of @entity1 and the innervation by various fiber types compared between the inflamed and intact TLF. Although the TLF is generally considered to have proprioceptive functions, no corpuscular proprioceptors (Pacini and Ruffini corpuscles) were found. To obtain quantitative data, the length of fibers and free nerve endings were determined in the three layers of the @entity1 TLF: inner layer (IL, adjacent to the multifidus muscle), middle layer (ML) and outer layer (OL). The main results were that the overall innervation density showed little change; however, there were significant changes in some of the layers. The innervation density was significantly decreased in the OL, but this change was partly compensated for by an increase in the IL. The density of substance @entity5 )-positive - presumably nociceptive - fibers was significantly increased. In contrast, the postganglionic sympathetic fibers were significantly decreased. In conclusion, the inflamed TLF showed an increase of presumably nociceptive fibers, which may explain the @entity2 from a pathologically altered fascia. The meaning of the decreased innervation by sympathetic fibers is obscure at present. The lack of proprioceptive corpuscular receptors within the TLF does not preclude its role as a proprioceptive structure, because some of the free nerve endings may function as proprioceptors.

title: Innervation changes induced by XXXX of the @entity1 thoracolumbar fascia.

answer: @entity0


abstract: UNASSIGNED: Recently, the fascia innervation has become an important issue, particularly the existence of nociceptive fibers. Fascia can be a source of @entity2 in several disorders such as @entity4 and non-specific @entity3 . However, nothing is known about possible changes of the fascia innervation under pathological circumstances. This question is important, because @entity2 from the fascia cannot only be due to increased nociceptor discharges, but also to a denser innervation of the fascia by nociceptive endings. In this histological study, an @entity0 was induced in the thoracolumbar fascia (TLF) of @entity1 and the innervation by various fiber types compared between the inflamed and intact TLF. Although the TLF is generally considered to have proprioceptive functions, no corpuscular proprioceptors (Pacini and Ruffini corpuscles) were found. To obtain quantitative data, the length of fibers and free nerve endings were determined in the three layers of the @entity1 TLF: inner layer (IL, adjacent to the multifidus muscle), middle layer (ML) and outer layer (OL). The main results were that the overall innervation density showed little change; however, there were significant changes in some of the layers. The innervation density was significantly decreased in the OL, but this change was partly compensated for by an increase in the IL. The density of substance @entity5 )-positive - presumably nociceptive - fibers was significantly increased. In contrast, the postganglionic sympathetic fibers were significantly decreased. In conclusion, the inflamed TLF showed an increase of presumably nociceptive fibers, which may explain the @entity2 from a pathologically altered fascia. The meaning of the decreased innervation by sympathetic fibers is obscure at present. The lack of proprioceptive corpuscular receptors within the TLF does not preclude its role as a proprioceptive structure, because some of the free nerve endings may function as proprioceptors.

title: Innervation changes induced by @entity0 of the XXXX thoracolumbar fascia.

answer: @entity1


abstract: BACKGROUND: Previous literature is varied with regard to rates of @entity3 after laparoscopic Roux-en-Y gastric bypass (LRYGB). Internal herniation through @entity1 is a common cause of @entity3 . There are advantages and disadvantages to routing the Roux limb via a retrocolic/retrogastric (RC/RG) versus an antecolic/antegastric (AC/AG) position. OBJECTIVE: To review the literature comparing obstruction rates in RYGB using the antecolic versus retrocolic approach. SETTING: Community-based integrated multispecialty health system with a teaching hospital serving 19 counties over a 3-state region. METHODS: A literature search for articles published from 1994-2013 was completed. Articles were included if they reported an n>25, Roux limb route, obstruction rate by route, and follow-up duration. Statistical analysis included   (2) test by @entity0 number. RESULTS: The initial search identified 241 articles; 8 met inclusion criteria. There were 4805 @entity0 in the AC/AG group, and 2238 in the RC/RG group. Follow-up ranged from 0 to 68 months. A linear stapled technique was reported in 4231 (88%) @entity0 in the AC/AG group and 1541 (69%) of RC/RG group. Handsewn closure of @entity1 was reported in 2152 (45%) @entity0 in the AC/AG group and 1012 (45%) @entity0 in the RC/RG group. @entity3 occurred in 68 (1.4%) @entity0 in the AC/AG group and 117 (5.2%) @entity0 in the RC/RG group (P<.001). Internal @entity2 were reported in 65 (1.3%) @entity0 in the AC/AG group and 52 (2.3%) @entity0 in the RC/RG group (P<.001). Two mortalities were reported in the AC/AG group. CONCLUSIONS: Increased rates of @entity3 were observed in the RC/RG group compared with the AC/AG group. A prospective, randomized trial would be necessary to definitively determine the impact of Roux limb position and routine closure of @entity1 on @entity3 rates after gastric bypass.

title: XXXX rates in antecolic/antegastric versus retrocolic/retrogastric Roux limb gastric bypass: a meta-analysis.

answer: @entity3