abstract: @entity5 (NST) and @entity4 / @entity4 (N/OFQ) are derived from the same precursor protein, pre-proN/OFQ, and exert opposite effects on the modulation of @entity2 signals. However, the role of the peripheral N/OFQ and the NOP receptor, which is located at the endings of sensory nerves, in @entity2 was not ascertained. NST administered intrathecally (i.t.) prevented the nociceptive effects induced by i.t. N/OFQ and PGE   . Moreover an up regulation of N/OFQ was shown in the @entity1 in response to peripheral @entity0 . Here, we investigated the effects of intraplantar (i.pl.) administration of functional N/OFQ and NOP receptor antagonists in a @entity1 model of @entity2 . Our findings showed that i.pl. injection of (  )- @entity6 , a selective antagonist of the NOP receptor, and NST, the functional N/OFQ antagonist, prior to carrageenan significantly reduced the paw allodynic and thermal @entity3 threshold induced by the inflammatory agent. The resulting antiallodynic and antihyperalgesic effects by co-administering NST and (  )-J 113397 prior to carrageenan were markedly enhanced, and the basal latencies were restored. Thus, it is likely that the peripheral N/OFQ/NOP receptor system contributes to the @entity2 sensitivity in an inflammatory state.

title: Effects of intraplantar nocistatin and (  )-J 113397 injections on nociceptive behavior in a XXXX model of @entity0 .

answer: @entity1


abstract: BACKGROUND: Various @entity3 occur about the ankle, but there are few publications investigating their etiology or pathoanatomy. The purpose of this investigation was to determine the gliding resistance of the tendons about the posteromedial ankle: the posterior tibial (PT), flexor digitorum longus (FDL), and @entity4 ( @entity4 ) tendons. MATERIALS AND METHODS: The gliding abilities of the posterior tibial, flexor digitorum longus, and @entity4 tendons at the ankle-hindfoot level were compared, in terms of gliding resistance, with use of a system that was developed in this laboratory. Six cadaveric specimens were used and tested in a dorsiflexed position, then in simulated @entity5 in a dorsiflexed position. RESULTS: The gliding resistance was found to be significantly greater in the simulated @entity5 in dorsiflexion compared to the dorsiflexed position with an intact arch for the PT, FDL, and @entity4 tendons. The gliding resistance was significantly higher in the PT tendon than FDL or @entity4 tendons in the @entity5 /dorsiflexion condition. There was no significant difference between the FDL and @entity4 tendons in resistance in either condition. CONCLUSION: We concluded that the gliding ability of the PT tendon was inferior to that of the FDL and @entity4 tendons in a simulated @entity5 model. CLINICAL RELEVANCE: The findings of the present study are consistent with the clinical observations that @entity3 and @entity1 of the PT tendon commonly occurs at the malleolar level, whereas FDL and @entity1 do not. A pre-existing flexible @entity0 may be associated with PT @entity2 in the adult due to poor gliding ability of the PT tendon.

title: The influence of XXXX on the gliding resistance of tendons about the ankle.

answer: @entity0


abstract: It was the aim of the study to assess differences in @entity0 morbidity between transmucosal implant placement and implant installation after elevation of mucoperiosteal flaps. In five of the @entity0 , implants were placed in the maxilla transmucosally using a CAD/CAM surgical template [ @entity3 ( @entity3 )]. In the remaining five @entity0 , the implants were installed after the elevation of mucoperiosteal flaps [control group (CG)]. Directly after surgery, at days 1 and 7 after surgery the @entity0 rated @entity2 and discomfort on a visual analogue scale (0=minimal @entity2 and discomfort, 100=maximal @entity2 and discomfort). Optical three-dimensional images were assessed preoperatively and at days 1 and 7 after surgery to determine the visible soft tissue swelling of the upper lip and cheeks. Directly postoperatively, the mean pairwise difference between both groups in view of @entity2 and discomfort ratings (control minus test) was 45.6 (SD, 20.7). At days 1 and 7, the mean differences were 51.6 (SD, 21.8) and 19 (SD, 8), respectively. The overall test of the area under curve (AUC) against the null hypothesis 'AUC of pairwise differences of @entity2 score over study time equals null' yielded a significant difference (P=0.01). The mean pairwise difference between both groups in view of soft tissue volume increase was 6.1 (SD, 2) cm(3) at day 1 after surgery and 4.6 (SD, 1.2) cm(3) at day 7. The overall test of the AUC against the null hypothesis 'AUC of pairwise differences of @entity1 measurements over study time equals null' yielded a significant difference (P=0.002). Within the limitations of this pilot study, it could be shown that transmucosal implant placement reduces @entity0 morbidity significantly compared with an open approach.

title: XXXX -centred outcomes comparing transmucosal implant placement with an open approach in the maxilla: a prospective, non-randomized pilot study.

answer: @entity0


abstract: @entity0 adenovirus-type 1 (MAV-1) has recently been shown to cause a fatal hemorrhagic @entity2 in certain strains of @entity0 whereas other strains are resistant. Morbidity is associated with a productive infection of cerebrovascular endothelial cells, resulting in @entity1 of the vasculature, @entity6 , @entity4 and @entity3 within 4 - 6 days. Previous studies were not able to define a role for the innate or acquired immune response. In the current study we have addressed the effect of MAV-1 on chemokine and chemokine receptor expression in the central nervous system (CNS) and spleen of susceptible (C57BL/6) and resistant (BALB/c) strains of @entity0 . Intra-peritoneal infection with MAV-1 in C57BL/6 animals resulted in early and prominent induction of @entity10 / @entity10 in the spleen and CNS. Increased expression of @entity7 , @entity9 , @entity11 and @entity5 was also noted in the CNS of MAV-1-infected C57BL/6 animals commencing around 72 h post-infection. In contrast, chemokine expression in BALB/c animals was more restricted with prominent upregulation only of @entity8 in the CNS. In situ hybridization identified the vascular endothelium and CNS glia as the principal site of @entity10 / @entity10 production in the C57BL/6 animals. The chemokine receptors @entity12 -5 were upregulated in the CNS of both strains of @entity0 . These data show that productive infection of the CNS with MAV-1 leads to the upregulation of a characteristic pattern of chemokines and their receptors, which may point to a role for these factors in disease pathogenesis.

title: Differential chemokine induction by the XXXX adenovirus type-1 in the central nervous system of susceptible and resistant strains of @entity0 .

answer: @entity0


abstract: @entity0 adenovirus-type 1 (MAV-1) has recently been shown to cause a fatal hemorrhagic @entity2 in certain strains of @entity0 whereas other strains are resistant. Morbidity is associated with a productive infection of cerebrovascular endothelial cells, resulting in @entity1 of the vasculature, @entity6 , @entity4 and @entity3 within 4 - 6 days. Previous studies were not able to define a role for the innate or acquired immune response. In the current study we have addressed the effect of MAV-1 on chemokine and chemokine receptor expression in the central nervous system (CNS) and spleen of susceptible (C57BL/6) and resistant (BALB/c) strains of @entity0 . Intra-peritoneal infection with MAV-1 in C57BL/6 animals resulted in early and prominent induction of @entity10 / @entity10 in the spleen and CNS. Increased expression of @entity7 , @entity9 , @entity11 and @entity5 was also noted in the CNS of MAV-1-infected C57BL/6 animals commencing around 72 h post-infection. In contrast, chemokine expression in BALB/c animals was more restricted with prominent upregulation only of @entity8 in the CNS. In situ hybridization identified the vascular endothelium and CNS glia as the principal site of @entity10 / @entity10 production in the C57BL/6 animals. The chemokine receptors @entity12 -5 were upregulated in the CNS of both strains of @entity0 . These data show that productive infection of the CNS with MAV-1 leads to the upregulation of a characteristic pattern of chemokines and their receptors, which may point to a role for these factors in disease pathogenesis.

title: Differential chemokine induction by the @entity0 adenovirus type-1 in the central nervous system of susceptible and resistant strains of XXXX .

answer: @entity0


abstract: Eradication programmes directed against Sarcoptes scabiei var. suis, performed without any disinfection of the environment, were compared to an eradication programme including a simultaneous environmental disinfection. The performance of such programmes would be facilitated considerably if environmental disinfection could be avoided. The trial was conducted in four conventional piglet-producing herds designated A-D. All herds suffered from a subclinical but persistent infection with the sarcoptic mite. Herd A was treated with two injections of @entity1 and simultaneously disinfection of the environment was done. In the other herds, the animals were treated twice (B and C) or three times (D) with acaricides (ivermectin or phoxim) at intervals of 7-12 days without any simultaneous disinfection of the buildings or environment. The results were monitored by attempts to demonstrate the mite by skin scrapings, and by monitoring the levels of serum antibodies to Sarcoptes scabiei by an ELISA. Samples were taken from all adults and from 20% of the piglets aged 10-12 weeks, before initiating the control programmes, every third month during the first year and a final sampling 18 months after the treatments. After treatment, the levels of antibodies continuously decreased. Presumably dead @entity2 were demonstrated in one sow from two of the herds 3 months after initiating acaricidal treatments. @entity2 was not demonstrated later, nor from skin scrapings of the piglets. The results obtained demonstrate that it is possible to eradicate sarcoptic mange mites in @entity0 herds with the use of simplified eradication programmes. The success of such programmes may efficiently be monitored by measuring the levels of serum antibodies to @entity2 .

title: The efficacy of simplified eradication strategies against sarcoptic mange mite infections in XXXX herds monitored by an ELISA.

answer: @entity0


abstract: OBJECTIVES: To evaluate the rate of @entity4 , length of stay, and 1-year mortality before and after introduction of a comprehensive multidisciplinary fast-track treatment and care program for @entity3 @entity0 (the optimized program). DESIGN: Retrospective chart review with historical control. SETTING: Orthopedic ward (110 beds) at a university hospital (700 beds). @entity0 : Five hundred thirty-five consecutive @entity0 aged 40 and older (94%>or=60) hospitalized for @entity3 between January 1, 2003, and March 31, 2004. Three hundred and thirty-six @entity0 (70.3%) were community dwellers before the fracture and 159 (29.7%) were admitted from nursing homes. INTERVENTION: The fast-track treatment and care program included a switch from systemic opiates to a local femoral nerve catheter block; an earlier assessment by the anesthesiologist; and a more-systematic approach to nutrition, fluid and @entity1 therapy, and urinary retention. RESULTS: In the intervention group, the rate of any in-hospital postoperative complication was reduced from 33% to 20% (odds ratio=0.61, 95% confidence interval=0.4-0.9; P=.002). Rates of @entity6 (P=.02), @entity2 (P=.03), and @entity5 (P<.001) were lower in the intervention group than in the control group, and length of stay was 15.8 days in the control group, versus 9.7 days in the intervention group (P<.001). For community dwellers, 12-month mortality was 23% in the control group versus 12% in the intervention group (P=.02). Overall 12-month mortality was 29% in the control group and 23% in the intervention group (P=.2). CONCLUSION: The optimized @entity3 program reduced the rate of in-hospital @entity4 and mortality. Randomized clinical trials are needed to confirm these results and elucidate the elements of the program that have the greatest effect on clinical outcomes and mortality.

title: A comprehensive XXXX program reduces complication rates and mortality.

answer: @entity3


abstract: Leucocyte trafficking in afferent and efferent mammary lymph and the supramammary lymph node in @entity0 was examined during 4 h after intramammary infusion of endotoxin from @entity1 . Total and differential leucocyte counts were measured in milk, blood and lymph. The proportions of @entity2 (+), CD8(+), major histocompatibility complex (MHC) class II(+) and IgM(+) lymphocytes were examined in the lymph and lymph node. At post-infusion hour (PIH) 4, the flow rates of both lymph fluids had increased approximately eightfold. Total leucocyte concentration increased in afferent lymph, but decreased in efferent lymph. Neutrophils increased in afferent lymph at PIH 2 and in efferent lymph and milk at PIH 4. The predominant cell type in afferent lymph shifted from lymphocyte to neutrophil while lymphocyte was still at PIH 4 the predominant type in efferent lymph. Among the lymphocytes, B cells were predominant in afferent lymph and lymph node at PIH 4 while T cells, mainly @entity2 (+) cells, were predominant in efferent lymph both at PIH 0 and PIH 4. The @entity2 : CD8 ratio was higher in efferent lymph and the challenged lymph node than in afferent lymph and the control node, respectively. There was a significant difference in proportions of each lymphocyte subpopulation except for IgM(+) cells, between afferent and efferent lymph after infusion. According to the results, there was already during the first hours of the immune response, a non-random trafficking of neutrophils and lymphocyte subpopulations resulting in a changed distribution of cells in afferent and efferent lymph and a difference in lymphocyte reactivity between the two lymph fluids.

title: Total and differential leucocyte counts and lymphocyte subpopulations in lymph, afferent and efferent to the supramammary lymph node, during endotoxin-induced XXXX mastitis.

answer: @entity0


abstract: AIM: to review admissions to the hospital due to @entity3 over a 10 year period. METHODS: This was a retrospective chart review of all paediatric @entity0 admitted to Townsville Hospital between 1996 and 2006 that were proven to have positive cultures for @entity4 . Details were obtained from the Microbiology Department of Townsville Hospital. RESULTS: Between 1996 and 2006, there were 150 cases of culture-confirmed @entity3 in North Queensland. Of these, eight (5.3%) were in @entity0 aged under 16 years. There were three deaths in this group. Three @entity0 developed @entity1 and there were no cases of parotid involvement. In our series, @entity1 appeared to be statistically more significant in @entity0 compared with adults. CONCLUSION: @entity3 is an uncommon @entity2 in Australia. In our series, @entity1 appeared to be common in @entity0 compared with adults with devastating sequelae. The reasons for this remain unclear.

title: XXXX in North Queensland, Australia.

answer: @entity3


abstract: @entity2 and symptom management at home following pediatric tonsillectomy and adenoidectomy (T _ A) is challenging. There are few randomized clinical trials that have established postoperative care interventions that are specific and effective during home recovery. The purpose of this pilot feasibility study was to describe how @entity0 and their families implemented a randomly assigned alarm intervention designed to promote postoperative around-the-clock administration of analgesics. Thirteen @entity0 from 12 through 18 years of age were randomly assigned to either the around-the-clock (RTC) intervention group (n = 7) or the usual care group (UCG) of controls (n = 6). The RTC intervention group was requested to use an alarm as a reminder to awaken and administer analgesia during the nighttime hours of sleep. @entity0 randomly assigned to the UCG of controls were given the same discharge education as the RTC intervention group that emphasized around-the-clock administration of analgesia. The UCG of controls were not requested to use the alarm intervention. Both groups documented @entity1 intensity and other symptoms daily for 3 days in a diary. All @entity0 wore an actigraphy-score wrist monitor to assess sleep during the same 3 days. Telephone interviews were conducted with the @entity0 and mothers at 24 hours and 10 to 14 days after surgery. Nonparametric statistics were used to compare differences between the two groups. @entity0 in the RTC intervention group administered significantly (p = .014) more analgesics by the second postoperative day than the UCG of controls. @entity1 intensity was moderate to severe for both groups. The mean hours of nighttime sleep for the two groups did not differ. Themes that emerged from the qualitative analysis of the interviews included painful challenges; struggling with decisions; making things work; a lengthy recovery; and family support. Results supported the need for research to establish evidenced-based home care interventions specific for T _ A postoperative recovery. Mothers and @entity0 suggested the need for education and support that extends longer into the recovery period.

title: Family exemplars during implementation of a home XXXX management intervention.

answer: @entity1


abstract: Ischemic @entity7 (iAKI) is a common event in organ transplantation and may occur during severe surgery. To gain mechanistic insights into @entity4 -induced alterations at the level of proximal tubule cells we set up an in vitro model of @entity4 and reperfusion using the @entity2 proximal tubule cell line NRK-52E. In this particular model we simultaneously applied @entity6 , @entity5 and aglycemia together for 2h, using low volume buffer systems and a @entity5 chamber. Thereafter reperfusion was mimicked by subsequently culturing the cells for up to 48h under standard conditions. In order to validate the system we investigated whether effects that take place in existing in vivo models of @entity4 and reperfusion can be observed. Namely, induction of @entity3 , apoptosis and of @entity4 reperfusion induced protein (IRIP), dedifferentiation (alphaSMA), @entity1 ( @entity10 ), @entity9 ( @entity9 ), release of @entity8 and basolateral uptake of organic anions. In fact, all parameters developed as described for the in vivo situation during reperfusion after @entity4 . Taken altogether we have established an in vitro model of proximal tubule cell @entity0 after @entity4 , showing typical changes described in vivo. Additionally, our model system is suitable for isolated application of the typical insults associated with @entity4 (e.g. @entity6 alone, @entity5 alone, aglycemia alone), in order to obtain more insight into the mechanistic events that lead to @entity0 in the kidney on the cellular level.

title: Implementation of an in vitro model system for investigation of XXXX after renal ischemia.

answer: @entity0


abstract: PURPOSE: To conduct the first randomized trial on classical and medium-chain @entity4 (MCT) versions of the ketogenic diet, examining efficacy and tolerability after 3, 6, and 12 months. METHODS: One hundred forty-five @entity0 with intractable @entity1 were randomized to receive a classical or an MCT diet. @entity3 frequency was assessed after 3, 6, and 12 months. Treatment withdrawals were documented. Tolerability was assessed by questionnaire, and blood @entity7 levels were measured. RESULTS: Of the 61 @entity0 who started a classical diet and the 64 who started an MCT diet, data from 94 were available for analysis: 45 classical and 49 MCT. After 3, 6, and 12 months there were no statistically significant differences in mean percentage of baseline @entity3 between the two groups (3 months: classical 66.5%, MCT 68.9%; 6 months: classical 48.5%, MCT 67.6%; 12 months: classical 40.8%, MCT 53.2%; all p > 0.05). There were no significant differences between groups in numbers achieving greater than 50% or 90% @entity3 reduction. Serum @entity6 and @entity5 levels at 3 and 6 months were significantly higher in @entity0 on the classical diet (p < 0.01); this was the case at 12 months for @entity6 . There were no significant differences in tolerability except increased reports in the classical group of lack of energy after 3 months and @entity2 after 12 months. DISCUSSION: This study has shown classical and MCT ketogenic diet protocols to be comparable in efficacy and tolerability; both ways of implementing the diet have their place in the treatment of childhood @entity1 .

title: A randomized trial of classical and medium-chain XXXX ketogenic diets in the treatment of childhood @entity1 .

answer: @entity4


abstract: PURPOSE: To conduct the first randomized trial on classical and medium-chain @entity4 (MCT) versions of the ketogenic diet, examining efficacy and tolerability after 3, 6, and 12 months. METHODS: One hundred forty-five @entity0 with intractable @entity1 were randomized to receive a classical or an MCT diet. @entity3 frequency was assessed after 3, 6, and 12 months. Treatment withdrawals were documented. Tolerability was assessed by questionnaire, and blood @entity7 levels were measured. RESULTS: Of the 61 @entity0 who started a classical diet and the 64 who started an MCT diet, data from 94 were available for analysis: 45 classical and 49 MCT. After 3, 6, and 12 months there were no statistically significant differences in mean percentage of baseline @entity3 between the two groups (3 months: classical 66.5%, MCT 68.9%; 6 months: classical 48.5%, MCT 67.6%; 12 months: classical 40.8%, MCT 53.2%; all p > 0.05). There were no significant differences between groups in numbers achieving greater than 50% or 90% @entity3 reduction. Serum @entity6 and @entity5 levels at 3 and 6 months were significantly higher in @entity0 on the classical diet (p < 0.01); this was the case at 12 months for @entity6 . There were no significant differences in tolerability except increased reports in the classical group of lack of energy after 3 months and @entity2 after 12 months. DISCUSSION: This study has shown classical and MCT ketogenic diet protocols to be comparable in efficacy and tolerability; both ways of implementing the diet have their place in the treatment of childhood @entity1 .

title: A randomized trial of classical and medium-chain @entity4 ketogenic diets in the treatment of childhood XXXX .

answer: @entity1


abstract: @entity1 of the head and neck region seldom appear in the midface and nasal cavity. Correct differential diagnosis of @entity1 is crucial for adequate therapy, as their clinical @entity4 seems to differ. The rather uncommon case of a 14-year-old @entity0 with a @entity1 of the middle turbinate is presented. The radiologic appearance of the @entity1 , on computed tomography and magnetic resonance imaging scans, was consistent with @entity3 . Angiography revealed extensive vascularisation of the @entity1 from both the internal and external carotid arteries. To avoid @entity5 following embolisation, a superselective embolisation of the supplying blood vessels was performed. The @entity1 was completely resected via an endoscopic approach. Histopathology revealed an ossifying @entity2 . This case emphasises the importance of interpretation of the clinical, radiological and histological features before planning definitive treatment. Moreover, when @entity1 are suspected, the possibility of extensive, complicated vascularisation must be considered. This case underwent radical resection, with no recurrence after four years' follow up.

title: Fibro-osseous lesion of the middle turbinate: ossifying @entity2 or XXXX ?

answer: @entity3


abstract: @entity1 of the head and neck region seldom appear in the midface and nasal cavity. Correct differential diagnosis of @entity1 is crucial for adequate therapy, as their clinical @entity4 seems to differ. The rather uncommon case of a 14-year-old @entity0 with a @entity1 of the middle turbinate is presented. The radiologic appearance of the @entity1 , on computed tomography and magnetic resonance imaging scans, was consistent with @entity3 . Angiography revealed extensive vascularisation of the @entity1 from both the internal and external carotid arteries. To avoid @entity5 following embolisation, a superselective embolisation of the supplying blood vessels was performed. The @entity1 was completely resected via an endoscopic approach. Histopathology revealed an ossifying @entity2 . This case emphasises the importance of interpretation of the clinical, radiological and histological features before planning definitive treatment. Moreover, when @entity1 are suspected, the possibility of extensive, complicated vascularisation must be considered. This case underwent radical resection, with no recurrence after four years' follow up.

title: Fibro-osseous lesion of the middle turbinate: ossifying XXXX or @entity3 ?

answer: @entity2


abstract: INTRODUCTION: @entity5 ( @entity5 ), @entity1 and their subsequent complication, the @entity4 ( @entity4 ), remain major complications following polytrauma. This prospective clinical study aimed at evaluating the association between these and plasma @entity7 ( @entity7 ) and @entity6 levels. METHODS: Inclusion in the series required an Injury Severity Score (ISS) >16, age 16-65 years, admission within 6 h of the accident and survival >48 h; 55 @entity0 were enrolled. Over 14 days, plasma @entity6 and @entity7 levels and the clinical course regarding @entity4 , @entity5 and @entity1 were recorded daily using the Marshall Score for @entity4 and the ACCP/SCCM criteria for @entity5 and @entity1 . RESULTS: @entity6 and @entity7 plasma levels were increased in + @entity4 cases as compared with - @entity4 cases over almost the entire observation period. @entity7 concentrations over days 3-6 were significantly increased among @entity0 with @entity1 . These increases were all apparent 2-3 days before the clinical diagnosis of @entity1 or @entity4 was made. In contrast, no significant differences in @entity6 and @entity7 plasma levels were observed between @entity0 with and without @entity5 . CONCLUSIONS: Determinations of @entity6 and @entity7 concentrations might represent early markers for posttraumatic complications such as @entity4 and @entity1 . They might help to differentiate between @entity5 and @entity1 and thereby guide the timing of the surgery for polytrauma. @entity6 and @entity7 levels should be used together with the clinical status and other inflammatory markers ( @entity2 , @entity3 , etc.) for prediction of posttraumatic complications.

title: Elevated systemic @entity7 and XXXX levels are associated with posttraumatic complications among @entity0 with multiple injuries: a prospective cohort study.

answer: @entity6


abstract: INTRODUCTION: @entity5 ( @entity5 ), @entity1 and their subsequent complication, the @entity4 ( @entity4 ), remain major complications following polytrauma. This prospective clinical study aimed at evaluating the association between these and plasma @entity7 ( @entity7 ) and @entity6 levels. METHODS: Inclusion in the series required an Injury Severity Score (ISS) >16, age 16-65 years, admission within 6 h of the accident and survival >48 h; 55 @entity0 were enrolled. Over 14 days, plasma @entity6 and @entity7 levels and the clinical course regarding @entity4 , @entity5 and @entity1 were recorded daily using the Marshall Score for @entity4 and the ACCP/SCCM criteria for @entity5 and @entity1 . RESULTS: @entity6 and @entity7 plasma levels were increased in + @entity4 cases as compared with - @entity4 cases over almost the entire observation period. @entity7 concentrations over days 3-6 were significantly increased among @entity0 with @entity1 . These increases were all apparent 2-3 days before the clinical diagnosis of @entity1 or @entity4 was made. In contrast, no significant differences in @entity6 and @entity7 plasma levels were observed between @entity0 with and without @entity5 . CONCLUSIONS: Determinations of @entity6 and @entity7 concentrations might represent early markers for posttraumatic complications such as @entity4 and @entity1 . They might help to differentiate between @entity5 and @entity1 and thereby guide the timing of the surgery for polytrauma. @entity6 and @entity7 levels should be used together with the clinical status and other inflammatory markers ( @entity2 , @entity3 , etc.) for prediction of posttraumatic complications.

title: Elevated systemic XXXX and @entity6 levels are associated with posttraumatic complications among @entity0 with multiple injuries: a prospective cohort study.

answer: @entity7


abstract: INTRODUCTION: @entity5 ( @entity5 ), @entity1 and their subsequent complication, the @entity4 ( @entity4 ), remain major complications following polytrauma. This prospective clinical study aimed at evaluating the association between these and plasma @entity7 ( @entity7 ) and @entity6 levels. METHODS: Inclusion in the series required an Injury Severity Score (ISS) >16, age 16-65 years, admission within 6 h of the accident and survival >48 h; 55 @entity0 were enrolled. Over 14 days, plasma @entity6 and @entity7 levels and the clinical course regarding @entity4 , @entity5 and @entity1 were recorded daily using the Marshall Score for @entity4 and the ACCP/SCCM criteria for @entity5 and @entity1 . RESULTS: @entity6 and @entity7 plasma levels were increased in + @entity4 cases as compared with - @entity4 cases over almost the entire observation period. @entity7 concentrations over days 3-6 were significantly increased among @entity0 with @entity1 . These increases were all apparent 2-3 days before the clinical diagnosis of @entity1 or @entity4 was made. In contrast, no significant differences in @entity6 and @entity7 plasma levels were observed between @entity0 with and without @entity5 . CONCLUSIONS: Determinations of @entity6 and @entity7 concentrations might represent early markers for posttraumatic complications such as @entity4 and @entity1 . They might help to differentiate between @entity5 and @entity1 and thereby guide the timing of the surgery for polytrauma. @entity6 and @entity7 levels should be used together with the clinical status and other inflammatory markers ( @entity2 , @entity3 , etc.) for prediction of posttraumatic complications.

title: Elevated systemic @entity7 and @entity6 levels are associated with posttraumatic complications among XXXX with multiple injuries: a prospective cohort study.

answer: @entity0


abstract: AIM: This paper analyzes the available data on the dosimetric approach and describes the use of dosimetry in the Division of Nuclear Medicine of the National @entity1 Institute in Milan. Dosimetry is rarely performed when planning radio- @entity4 activity, although most of the available guidelines do mention this possibility, without giving any well defined indication. Aim of the present research was to validate the usefulness of dosimetry in the management of metastatic @entity3 . Benua (1962) set the limit of blood absorbed dose at 2 Gy to avoid hematological @entity2 . Maxon (1983) determined at 80 Gy the dose to achieve complete destruction of a metastatic lesion. Dorn (2003) combined red marrow and lesion dosimetry showing that high activity administrations with less that 3 Gy to the red marrow are a safe and more effective with respect to fixed activities administrations. Lee (2008) reported 50% responses with high activity administrations based on blood dosimetry, in 47 @entity0 which were unsuccessfully previously treated with fixed activities. Sgouros (2005) and Song (2006) introduced key parameters as Biological Effective Dose and Uniform Equivalent Dose in order to describe the effects of continuous low dose rate irradiation and non uniform activity uptake, typical of nuclear medicine treatments. METHODS: Red marrow and lesion dosimetry (planar view) were performed during the treatment, without changing the fixed @entity5 . RESULTS: This experience demonstrate first of all, that dosimetry is feasible in the clinical routine, and that it can provide the clinician with important information, no matter its often quoted limited numerical accuracy. A total of 17/20 lesion doses below 80 Gy have been detected. Three/17 (doses between 40 and 80 Gy) disappeared in the follow-up scintigram. Two/17 were undetectable at computed tomography or nuclear magnetic resonance. These data suggest that repetition of treatment on a lesion drastically reduces its uptake, with a loss of therapeutic efficacy along the sequence of fixed activity administrations. CONCLUSIONS: The usefulness of dosimetry should not be assessed only on the basis of @entity0 survival or therapeutic efficacy; the possibility to avoid useless treatments should also be considered. According to the authors, individualized dosimetry could improve the management of metastatic @entity3 . Even post-therapeutic dosimetry, as performed at this institution, has a significant impact on clinical decision-making. The question for the future is how to include dosimetry into the @entity0 management framework.

title: Individualized dosimetry in the management of metastatic XXXX .

answer: @entity3


abstract: Allergen isoforms can differ in their IgE and T cell recognition patterns, and thus might have an impact on the selection of candidates for molecule-based diagnostic and therapeutic approaches. The present study aimed at the identification and characterization of isoforms of Art v 1, the mugwort @entity3 major allergen. In addition, single Art v 1 domains were physicochemically and immunologically characterized. For this purpose, the Art v 1 cDNA was radiolabeled and used to screen a mugwort @entity3 cDNA library. Positive clones were sequenced and used for the production of recombinant proteins in @entity0 using the pHIS-Parallel2 vector. Protein purification was performed by affinity- and ion exchange chromatography. Antibody binding to the recombinant proteins was determined by immunoblot, ELISA, cross-inhibition experiments, and mediator release assays. We could identify 7 Art v 1 isoforms differing in 1-6 @entity1 residues. Interestingly, all @entity1 variations were restricted to the @entity2 domain carrying the molecule's post-translational modifications. No significant difference in IgG or IgE reactivity could be observed between Art v 1 isoforms and the defensin domain produced in @entity0 . When expressed in @entity0 , the @entity2 domain was not recognized by Art v 1-specific antibodies. Our results demonstrated that the relevant IgE epitopes of Art v 1 are located on the defensin domain and suggest the involvement of @entity4 in the allergenicity of natural Art v 1. Plant-based expression systems could help to reveal possibly different glycosylation patterns and IgE binding properties of Art v 1 isoforms. These findings have direct implications on the development of novel tools for mugwort @entity3 allergy diagnosis and therapy.

title: Immune recognition of novel isoforms and domains of the mugwort XXXX major allergen Art v 1.

answer: @entity3


abstract: OBJECTIVES: A wide range of low-molecular-weight agents can cause @entity4 . The chemical industry is an environment in which numerous hazardous substances are used. @entity6 ( @entity6 ) is one of them (along with its precursors). METHODS: Five @entity0 from a @entity6 production line with suspected @entity4 and @entity3 were examined. During the first visit, skin prick tests, total @entity5 ( @entity5 ), a nonspecific bronchoprovocation test, and specific bronchoprovocation tests using occupational agents were performed to confirm the diagnosis of @entity1 . During the follow-up visit (1-3 years after removal from exposure), all of the tests (except the specific bronchoprovocation test) were performed again. RESULTS: At the first hospitalization, the total @entity5 levels were increased in three @entity0 . In addition, skin prick tests and the nonspecific bronchoprovocation test were positive for three @entity0 . After the specific bronchoprovocation test, serious bronchoconstriction occurred in three @entity0 ; symptoms of @entity3 were present in all five @entity0 . Several years after removal from exposure to the occupational agents, normalization (with respect to the parameters followed) was not yet complete for all of the @entity0 . CONCLUSIONS: The process of @entity6 production seems to be hazardous and is likely to cause @entity2 . The prognosis of @entity1 caused by these products is not very favorable. @entity1 (despite the removal from occupational allergen exposure) persisted even after several years.

title: Occupational asthma and @entity3 in workers from a XXXX production line.

answer: @entity6


abstract: OBJECTIVES: A wide range of low-molecular-weight agents can cause @entity4 . The chemical industry is an environment in which numerous hazardous substances are used. @entity6 ( @entity6 ) is one of them (along with its precursors). METHODS: Five @entity0 from a @entity6 production line with suspected @entity4 and @entity3 were examined. During the first visit, skin prick tests, total @entity5 ( @entity5 ), a nonspecific bronchoprovocation test, and specific bronchoprovocation tests using occupational agents were performed to confirm the diagnosis of @entity1 . During the follow-up visit (1-3 years after removal from exposure), all of the tests (except the specific bronchoprovocation test) were performed again. RESULTS: At the first hospitalization, the total @entity5 levels were increased in three @entity0 . In addition, skin prick tests and the nonspecific bronchoprovocation test were positive for three @entity0 . After the specific bronchoprovocation test, serious bronchoconstriction occurred in three @entity0 ; symptoms of @entity3 were present in all five @entity0 . Several years after removal from exposure to the occupational agents, normalization (with respect to the parameters followed) was not yet complete for all of the @entity0 . CONCLUSIONS: The process of @entity6 production seems to be hazardous and is likely to cause @entity2 . The prognosis of @entity1 caused by these products is not very favorable. @entity1 (despite the removal from occupational allergen exposure) persisted even after several years.

title: Occupational asthma and XXXX in workers from a @entity6 production line.

answer: @entity3


abstract: OBJECTIVE: This study was undertaken to document physical injuries and ascertain associated variables in female complainants of @entity3 . STUDY DESIGN: 164 cases of @entity3 between 2002 and 2006 in Belfast were included. 162 @entity0 consented to body examination and 153 to genital examination. Data for the study were obtained from the contemporaneous notes of a forensic doctor who examined the victims. RESULTS: Of 164 females, 44% were less than 20 years of age, mean age was 24.2, range 13-74 years; two-thirds reported @entity2 consumption prior to assault. @entity1 was observed in 61%, @entity1 in 39%, both in 20% and 18% had no injury. Body injury was associated with time to examination (OR=4.0, p<0.01), @entity2 intake prior to assault (OR=3.33, p<0.001), assault occurring outdoors (OR=3.45, p<0.01), previous sexual intercourse (OR=3.19, p<0.01) and @entity1 (OR=2.24, p<0.05). @entity1 was related to acquaintance assault (OR=2.33, p<0.05), time to examination (OR=3.70, p<0.05), reported virgin status (OR=3.03, p<0.01) and absence of hormonal contraception (OR=2.04, p<0.10). CONCLUSION: Almost half the victims of @entity3 were less than 20 years old and injury was detected in over 80%. Time to examination and prior sexual experience were @entity1 . Assault occurring outdoors and @entity2 intake were associated with @entity1 . @entity1 was more frequent in acquaintance assault and victims not using hormonal contraception. Young females drinking @entity2 are at a very high risk for @entity3 .

title: Injury in adult female XXXX and related factors.

answer: @entity3


abstract: 1. The progressive effects of a single injection (3mg/kg i.v.) of either @entity4 or @entity3 on the innervation of the @entity0 atria have been examined. 2. Functional studies were performed by stimulating electrically the noradrenergic or cholinergic nerve fibres within isolated left atria from treated and control @entity0 . In addition, the effects of the drugs on the ultrastructure of both types of nerve fibre were examined. The noradrenergic innervation was further examined by fluorescence histochemistry and measurement of the @entity2 content of the atria. 3. On the basis of these studies it appeared that both drugs caused @entity1 ; cholinergic nerves seemed to be unaffected. Marked effects were seen 48 h after @entity4 treatment or 30 h after @entity3 treatment. 4. Evidence is presented and discussed as to whether or not this action of the vinca alkaloids can be ascribed to their well-established effects on microtubules and intra-axonal transport processes.

title: Selective noradrenergic denervation of the heart following intravenous injections of XXXX or @entity3 .

answer: @entity4


abstract: 1. The progressive effects of a single injection (3mg/kg i.v.) of either @entity4 or @entity3 on the innervation of the @entity0 atria have been examined. 2. Functional studies were performed by stimulating electrically the noradrenergic or cholinergic nerve fibres within isolated left atria from treated and control @entity0 . In addition, the effects of the drugs on the ultrastructure of both types of nerve fibre were examined. The noradrenergic innervation was further examined by fluorescence histochemistry and measurement of the @entity2 content of the atria. 3. On the basis of these studies it appeared that both drugs caused @entity1 ; cholinergic nerves seemed to be unaffected. Marked effects were seen 48 h after @entity4 treatment or 30 h after @entity3 treatment. 4. Evidence is presented and discussed as to whether or not this action of the vinca alkaloids can be ascribed to their well-established effects on microtubules and intra-axonal transport processes.

title: Selective noradrenergic denervation of the heart following intravenous injections of @entity4 or XXXX .

answer: @entity3


abstract: Occlusion of @entity3 (MCAo) is commonly used to generate @entity1 in experimental animals. Different behavioral assays have been used to evaluate the severity of lesions or recovery after treatment in this model. In this study, we examined the correlation between the size of @entity2 after transient MCAo in adult @entity0 . The right @entity3 was occluded for 30-90-min by ligation with a 10-O suture. At 2 days after MCAo, animals were individually placed in a 3-D infrared activity chamber for 1h to measure their horizontal, vertical, stereotypic and rotational activity. Body asymmetry was examined using an elevated body swing test. Volume of @entity2 was measured by @entity4 staining. We found that there is a significant correlation between the volume of @entity2 , such as vertical activity, vertical movement number and vertical movement time. There is also a significant correlation between the @entity2 volume and body asymmetry. In conclusion, our data suggest that vertical locomotor activity and body asymmetry are useful behavioral indices to estimate the size of lesioning in rodents after MCAo.

title: Correlation of locomotor activity and brain infarction in XXXX with transient focal ischemia.

answer: @entity0


abstract: Hypoglossal motoneurons (HMNs) innervate all tongue muscles and are vital for maintenance of upper airway patency during inspiration. The relative contributions of the various synaptic inputs to the spontaneous discharge of HMNs in vivo are incompletely understood, especially at the cellular level. The purpose of this study was to determine the role of endogenously activated @entity4 (A) and @entity7 receptors in the control of the inspiratory HMN (IHMN) activity in a decerebrate @entity0 model. Multibarrel micropipettes were used to record extracellular unit activity of individual IHMNs during local antagonism of @entity4 (A) receptors with @entity3 and @entity6 or @entity7 receptors with @entity2 . Only @entity3 had a significant effect on peak and average discharge frequency and on the slope of the augmenting neuronal discharge pattern. These parameters were increased by 30 +/- 7% (P < 0.001), 30 +/- 8% (P < 0.001), and 25 +/- 7% (P < 0.001), respectively. The effects of @entity6 and @entity2 on the spontaneous neuronal discharge and its pattern were negligible. Our data suggest that @entity3 -sensitive GABAergic, but not @entity6 -sensitive GABAergic or glycinergic, inhibitory mechanisms actively attenuate the activity of IHMNs in vagotomized decerebrate @entity0 during hyperoxic @entity5 . The pattern of GABAergic attenuation of IHMN discharge is characteristic of gain modulation similar to that in @entity1 , but the degree of attenuation ( approximately 25%) is less than that seen in bulbospinal premotor neurons ( approximately 60%). The current studies only assess effects on active neuron discharge and do not resolve whether the lack of effect of @entity6 and @entity2 on IHMNs also extends to the inactive expiratory phase.

title: Role of inhibitory neurotransmission in the control of XXXX hypoglossal motoneuron activity in vivo.

answer: @entity0


abstract: It has been well established that the amygdala is critical for processing various aspects of emotion, and in particular, for the perception of negative emotions such as fear. Perhaps the strongest evidence for this conclusion in @entity0 comes from an extensive series of investigations in @entity0 SM, an extremely rare neurological @entity0 who has complete, focal bilateral @entity1 . One question that has remained unanswered, however, is whether SM has a normal phenomenological experience of emotion, especially negative emotion. To explore this issue, we designed a study in which two experienced clinical psychologists conducted "blind" interviews of SM (the psychologists were not provided any background information regarding SM), with a special emphasis regarding the nature of her emotional experience. Both of them reached the conclusion that SM expressed a normal range of affect and emotion, and neither felt that SM warranted a DSM-IV diagnosis. However, they both noted that SM was remarkably dispassionate when relating highly emotional and traumatic life experiences, and they noted that she did not seem to have a normal sense of distrust and "danger". To the psychologists, SM came across as a "survivor", as being "resilient" and even "heroic" in the way that she had dealt with adversity in her life. In the full light of SM's neurological and neuropsychological profile, however, these observations reflect the fact that SM is missing from the experiences in her life some of the @entity2 , in a manner that parallels her defect in perceiving such emotions in external stimuli. These findings have interesting parallels with recent animal work (cf. Bauman, Lavenex, Mason, Capitanio, _ Amaral, 2004a), and they provide valuable insights into the emotional life of an individual with complete bilateral @entity1 .

title: Altered experience of emotion following bilateral XXXX .

answer: @entity1


abstract: PURPOSE: To evaluate the radiological, ultrasonographic, and magnetic resonance imaging (MRI) findings of idiopathic @entity4 . MATERIAL AND METHODS: Between April 2002 and June 2005, the mammography, ultrasound, color Doppler ultrasound, nonenhanced MR, and dynamic MR findings of nine @entity0 with the preliminary clinical diagnosis of @entity1 and the final diagnosis of @entity4 were evaluated. RESULTS: On mammography, asymmetrical focal densities with no distinct margins, ill-defined masses with spiculated contours, and bilateral multiple ill-defined nodules were seen. On ultrasound, in four @entity0 a discrete, heterogenous hypoechoic mass, in two @entity0 multiple abscesses, in one @entity0 bilateral multiple central hypo peripheral @entity2 , in two @entity0 heterogeneous hypo- and hyperechoic areas together with parenchymal distortion, and in one @entity0 irregular hypoechoic masses with tubular extensions and @entity3 were seen. Five of the lesions were vascular on color Doppler ultrasound. On MR mammography, the most frequent finding was focal or diffuse asymmetrical signal intensity changes that were hypointense on T1W images and hyperintense on T2W images, without significant mass effect. Nodular lesions were also seen. On dynamic contrast-enhanced mammography, mass-like enhancement, ring-like enhancement, and nodular enhancement were seen. The time-intensity curves differed from @entity0 to @entity0 and from lesion to lesion. CONCLUSION: The imaging findings of idiopathic @entity4 have a wide spectrum, and they are inconclusive for differentiating @entity1 .

title: XXXX : radiological findings.

answer: @entity4


abstract: BACKGROUND: Primary cutaneous @entity8 form a heterogeneous group of lymphoid proliferations found on the skin. We report a case of primary leg-type cutaneous large @entity8 occurring on the site a previous leg burn. A few rare cases of @entity4 forming on burn scars have been described, but these concern primary @entity4 of the T-cell phenotype. CASE REPORT: An 85-year-old @entity0 with a history of a burn to the left leg 17 years ago, previously treated with several skin grafts, presented numerous ulcerative budding lesions on the scar area. Histological examination of the skin biopsy revealed the existence in the skin ulcers of atypical large lymphoid cells having an immunoblastic or centroblastic morphology and shown by immunohistochemistry to be of the B-cell phenotype, thereby evoking a diagnosis of large @entity8 . The @entity4 cells were positive for @entity13 / @entity14 and @entity3 , and more weakly for @entity11 , but negative for @entity9 . The staging examination revealed only cortical lysis of the left tibia. Temporary initial regression was achieved by polychemotherapy comprising @entity5 , @entity7 and @entity2 in combination with rituximab. DISCUSSION: This case is novel in that it involves primary large @entity8 , leg type, occurring on @entity10 . @entity12 and lymphatic stasis have already been incriminated in the genesis of this type of @entity4 ; the prior @entity6 at the burn site may have also contributed to the development of this @entity1 .

title: [Cutaneous large B-cell leg-type XXXX occurring on a leg burn].

answer: @entity4


abstract: @entity1 causes profound alterations in many body tissues. Microvascular @entity1 complications include @entity9 , @entity2 and @entity5 . @entity2 first becomes manifest with hyperfiltration and microalbuminuria. These functional changes evolve over several years to a stage of marked @entity4 . The possible preventive measures are metabolic control, reduction of dietary protein intake and use of ACE-inhibitors. Metabolic control is also important for the prevention of @entity1 . In fact, @entity0 with HbA1c higher than 10% have an increased risk of progression of @entity5 . Moreover, an accelerated progression of @entity5 has been observed in @entity0 with systemic @entity3 following the onset of microalbuminuria. It has been demonstrated that @entity9 can also be present during childhood; therefore, it is possible to detect electrophysiological abnormalities in @entity0 and adolescents with @entity6 . Glycaemic and blood pressure control are, so far, the main means for possible prevention or modification of the natural history of @entity7 . Tight glycaemic control may have beneficial effects for @entity9 . In addition, other preventive measures, such as @entity8 reductase inhibitors, gangliosides, neurotrophic vitamins, etc., have been studied in the last years. However, no conclusive results have been obtained so far.

title: Prevention of microvascular complications in XXXX @entity0 and adolescents.

answer: @entity1


abstract: @entity1 causes profound alterations in many body tissues. Microvascular @entity1 complications include @entity9 , @entity2 and @entity5 . @entity2 first becomes manifest with hyperfiltration and microalbuminuria. These functional changes evolve over several years to a stage of marked @entity4 . The possible preventive measures are metabolic control, reduction of dietary protein intake and use of ACE-inhibitors. Metabolic control is also important for the prevention of @entity1 . In fact, @entity0 with HbA1c higher than 10% have an increased risk of progression of @entity5 . Moreover, an accelerated progression of @entity5 has been observed in @entity0 with systemic @entity3 following the onset of microalbuminuria. It has been demonstrated that @entity9 can also be present during childhood; therefore, it is possible to detect electrophysiological abnormalities in @entity0 and adolescents with @entity6 . Glycaemic and blood pressure control are, so far, the main means for possible prevention or modification of the natural history of @entity7 . Tight glycaemic control may have beneficial effects for @entity9 . In addition, other preventive measures, such as @entity8 reductase inhibitors, gangliosides, neurotrophic vitamins, etc., have been studied in the last years. However, no conclusive results have been obtained so far.

title: Prevention of microvascular complications in @entity1 XXXX and adolescents.

answer: @entity0


abstract: The distributions of @entity7 (OFQ/N; also known as @entity7 ) and its cognate receptor, opioid receptor-like receptor-1 (NOP), overlap steroid-responsive regions throughout reproductive circuits of the limbic system and hypothalamus. For example, in the ventromedial nucleus of the hypothalamus (VMH), OFQ/N facilitates @entity5 in female @entity0 through @entity2 and @entity4 regulation of @entity7 activity. We studied @entity2 and @entity4 regulation of OFQ/N and NOP mRNA expression in limbic-hypothalamic reproductive circuits. Ovariectomized @entity0 were treated with @entity6 (2 microg) and 26 hours later with oil or @entity4 (500 microg) and were killed 30 hours after initial treatment. Alternate brain sections were processed for OFQ/N or NOP mRNA in situ hybridization. High levels of hybridization for NOP and OFQ/N and overlapping distributions were observed throughout the limbic hypothalamic reproductive circuits; however, in VMH, only NOP expression was observed. @entity2 treatment increased NOP mRNA expression in anteroventral periventricular nucleus (AVPV), median preoptic nucleus, and VMH. Subsequent @entity4 treatment did not alter @entity2 -induced expression of NOP mRNA in VMH or median preoptic nucleus but reduced expression in the AVPV. OFQ/N mRNA levels were also regulated by @entity3 . In the caudal part of the posterodorsal medial amygdala, @entity2 increased OFQ/N mRNA levels, and @entity4 did not alter this increase, whereas, in the medial part of the medial preoptic nucleus, @entity2 and @entity4 were needed to increase OFQ/N mRNA levels. @entity1 regulation of OFQ/N and NOP in the medial preoptic nucleus and VMH is consistent with emerging data indicating that this opioid system regulates female reproduction.

title: Site-specific XXXX and progestin regulation of @entity7 / @entity7 and @entity7 opioid receptor mRNA expression in the female @entity0 limbic hypothalamic system.

answer: @entity2


abstract: The distributions of @entity7 (OFQ/N; also known as @entity7 ) and its cognate receptor, opioid receptor-like receptor-1 (NOP), overlap steroid-responsive regions throughout reproductive circuits of the limbic system and hypothalamus. For example, in the ventromedial nucleus of the hypothalamus (VMH), OFQ/N facilitates @entity5 in female @entity0 through @entity2 and @entity4 regulation of @entity7 activity. We studied @entity2 and @entity4 regulation of OFQ/N and NOP mRNA expression in limbic-hypothalamic reproductive circuits. Ovariectomized @entity0 were treated with @entity6 (2 microg) and 26 hours later with oil or @entity4 (500 microg) and were killed 30 hours after initial treatment. Alternate brain sections were processed for OFQ/N or NOP mRNA in situ hybridization. High levels of hybridization for NOP and OFQ/N and overlapping distributions were observed throughout the limbic hypothalamic reproductive circuits; however, in VMH, only NOP expression was observed. @entity2 treatment increased NOP mRNA expression in anteroventral periventricular nucleus (AVPV), median preoptic nucleus, and VMH. Subsequent @entity4 treatment did not alter @entity2 -induced expression of NOP mRNA in VMH or median preoptic nucleus but reduced expression in the AVPV. OFQ/N mRNA levels were also regulated by @entity3 . In the caudal part of the posterodorsal medial amygdala, @entity2 increased OFQ/N mRNA levels, and @entity4 did not alter this increase, whereas, in the medial part of the medial preoptic nucleus, @entity2 and @entity4 were needed to increase OFQ/N mRNA levels. @entity1 regulation of OFQ/N and NOP in the medial preoptic nucleus and VMH is consistent with emerging data indicating that this opioid system regulates female reproduction.

title: Site-specific @entity2 and progestin regulation of XXXX / @entity7 and @entity7 opioid receptor mRNA expression in the female @entity0 limbic hypothalamic system.

answer: @entity7


abstract: The distributions of @entity7 (OFQ/N; also known as @entity7 ) and its cognate receptor, opioid receptor-like receptor-1 (NOP), overlap steroid-responsive regions throughout reproductive circuits of the limbic system and hypothalamus. For example, in the ventromedial nucleus of the hypothalamus (VMH), OFQ/N facilitates @entity5 in female @entity0 through @entity2 and @entity4 regulation of @entity7 activity. We studied @entity2 and @entity4 regulation of OFQ/N and NOP mRNA expression in limbic-hypothalamic reproductive circuits. Ovariectomized @entity0 were treated with @entity6 (2 microg) and 26 hours later with oil or @entity4 (500 microg) and were killed 30 hours after initial treatment. Alternate brain sections were processed for OFQ/N or NOP mRNA in situ hybridization. High levels of hybridization for NOP and OFQ/N and overlapping distributions were observed throughout the limbic hypothalamic reproductive circuits; however, in VMH, only NOP expression was observed. @entity2 treatment increased NOP mRNA expression in anteroventral periventricular nucleus (AVPV), median preoptic nucleus, and VMH. Subsequent @entity4 treatment did not alter @entity2 -induced expression of NOP mRNA in VMH or median preoptic nucleus but reduced expression in the AVPV. OFQ/N mRNA levels were also regulated by @entity3 . In the caudal part of the posterodorsal medial amygdala, @entity2 increased OFQ/N mRNA levels, and @entity4 did not alter this increase, whereas, in the medial part of the medial preoptic nucleus, @entity2 and @entity4 were needed to increase OFQ/N mRNA levels. @entity1 regulation of OFQ/N and NOP in the medial preoptic nucleus and VMH is consistent with emerging data indicating that this opioid system regulates female reproduction.

title: Site-specific @entity2 and progestin regulation of @entity7 / XXXX and @entity7 opioid receptor mRNA expression in the female @entity0 limbic hypothalamic system.

answer: @entity7


abstract: The distributions of @entity7 (OFQ/N; also known as @entity7 ) and its cognate receptor, opioid receptor-like receptor-1 (NOP), overlap steroid-responsive regions throughout reproductive circuits of the limbic system and hypothalamus. For example, in the ventromedial nucleus of the hypothalamus (VMH), OFQ/N facilitates @entity5 in female @entity0 through @entity2 and @entity4 regulation of @entity7 activity. We studied @entity2 and @entity4 regulation of OFQ/N and NOP mRNA expression in limbic-hypothalamic reproductive circuits. Ovariectomized @entity0 were treated with @entity6 (2 microg) and 26 hours later with oil or @entity4 (500 microg) and were killed 30 hours after initial treatment. Alternate brain sections were processed for OFQ/N or NOP mRNA in situ hybridization. High levels of hybridization for NOP and OFQ/N and overlapping distributions were observed throughout the limbic hypothalamic reproductive circuits; however, in VMH, only NOP expression was observed. @entity2 treatment increased NOP mRNA expression in anteroventral periventricular nucleus (AVPV), median preoptic nucleus, and VMH. Subsequent @entity4 treatment did not alter @entity2 -induced expression of NOP mRNA in VMH or median preoptic nucleus but reduced expression in the AVPV. OFQ/N mRNA levels were also regulated by @entity3 . In the caudal part of the posterodorsal medial amygdala, @entity2 increased OFQ/N mRNA levels, and @entity4 did not alter this increase, whereas, in the medial part of the medial preoptic nucleus, @entity2 and @entity4 were needed to increase OFQ/N mRNA levels. @entity1 regulation of OFQ/N and NOP in the medial preoptic nucleus and VMH is consistent with emerging data indicating that this opioid system regulates female reproduction.

title: Site-specific @entity2 and progestin regulation of @entity7 / @entity7 and XXXX opioid receptor mRNA expression in the female @entity0 limbic hypothalamic system.

answer: @entity7


abstract: The distributions of @entity7 (OFQ/N; also known as @entity7 ) and its cognate receptor, opioid receptor-like receptor-1 (NOP), overlap steroid-responsive regions throughout reproductive circuits of the limbic system and hypothalamus. For example, in the ventromedial nucleus of the hypothalamus (VMH), OFQ/N facilitates @entity5 in female @entity0 through @entity2 and @entity4 regulation of @entity7 activity. We studied @entity2 and @entity4 regulation of OFQ/N and NOP mRNA expression in limbic-hypothalamic reproductive circuits. Ovariectomized @entity0 were treated with @entity6 (2 microg) and 26 hours later with oil or @entity4 (500 microg) and were killed 30 hours after initial treatment. Alternate brain sections were processed for OFQ/N or NOP mRNA in situ hybridization. High levels of hybridization for NOP and OFQ/N and overlapping distributions were observed throughout the limbic hypothalamic reproductive circuits; however, in VMH, only NOP expression was observed. @entity2 treatment increased NOP mRNA expression in anteroventral periventricular nucleus (AVPV), median preoptic nucleus, and VMH. Subsequent @entity4 treatment did not alter @entity2 -induced expression of NOP mRNA in VMH or median preoptic nucleus but reduced expression in the AVPV. OFQ/N mRNA levels were also regulated by @entity3 . In the caudal part of the posterodorsal medial amygdala, @entity2 increased OFQ/N mRNA levels, and @entity4 did not alter this increase, whereas, in the medial part of the medial preoptic nucleus, @entity2 and @entity4 were needed to increase OFQ/N mRNA levels. @entity1 regulation of OFQ/N and NOP in the medial preoptic nucleus and VMH is consistent with emerging data indicating that this opioid system regulates female reproduction.

title: Site-specific @entity2 and progestin regulation of @entity7 / @entity7 and @entity7 opioid receptor mRNA expression in the female XXXX limbic hypothalamic system.

answer: @entity0


abstract: The objective of this study was to develop an adenoviral vector system that would generate a pattern of expression of exogenous therapeutic genes appropriate for the treatment of @entity1 . For this purpose, we have generated a replication-deficient recombinant adenoviral vector, AdLPLacZ, which contains the @entity0 @entity8 ( @entity8 ) promoter ( @entity8 -P) driving the @entity2 LacZ gene. @entity8 is constitutively expressed at high levels in malignant epithelial cells but is not expressed in normal tissues, except at low levels in mature hematopoietic cells. Because adenoviral vectors infect early hematopoietic multilineage precursor cells only poorly or not at all, this vector would be of use in the peritoneal cavity and in vitro for marrow purging. We first analyzed the expression of the LacZ reporter gene in @entity6 cell lines, normal fibroblasts, and @entity4 cell lines using the adenoviral vector in which the LacZ gene is governed by the LP-P promoter (AdLPLacZ) or in which the LacZ gene is governed by the cytomegalovirus ( @entity5 ) promoter (AdCMVLacZ). We found equivalent and high levels of expression of @entity7 ( @entity7 ) by AdLPLacZ and AdCMVLacZ vectors in the @entity6 cell lines as well as in a @entity3 cell line, indicating that the adenoviral vectors infected these cells and expressed their transgenes equally with the LP and @entity5 promoters. Expression of the LacZ gene with the @entity5 vector but not with the LP-P vector was observed in experiments with normal fibroblasts, indicating that the vectors infected the cells, but that the LP-P was not active within them. In hematopoietic cells such as U937 cells, no measurable @entity7 activity was detected in cells infected either by AdLPLacZ or by AdCMVLacZ, indicating that the adenoviral vectors were not infecting the cells. Although @entity7 activity was observed in fresh ascitic @entity1 cells after infection with adenoviral vectors containing @entity5 or the LP promoters, @entity7 activity was detected in a portion of a biopsy of normal peritoneum when the tissues were exposed to the AdCMVLacZ vector, but not when tissues were exposed to the AdLPLacZ vector. These results suggest that the transcription of therapeutic genes in cells infected by the AdLP vectors would be restricted to LP expression-positive @entity1 cells but would not be seen in the normal mesothelial cells of the peritoneal cavity. This possibility implies that adenoviral vectors carrying therapeutic genes driven by the LP-P would be of use for the @entity1 .

title: Use of @entity8 promoter to develop an adenoviral system that confers transgene expression in XXXX cells but not in normal mesothelial cells.

answer: @entity1


abstract: The objective of this study was to develop an adenoviral vector system that would generate a pattern of expression of exogenous therapeutic genes appropriate for the treatment of @entity1 . For this purpose, we have generated a replication-deficient recombinant adenoviral vector, AdLPLacZ, which contains the @entity0 @entity8 ( @entity8 ) promoter ( @entity8 -P) driving the @entity2 LacZ gene. @entity8 is constitutively expressed at high levels in malignant epithelial cells but is not expressed in normal tissues, except at low levels in mature hematopoietic cells. Because adenoviral vectors infect early hematopoietic multilineage precursor cells only poorly or not at all, this vector would be of use in the peritoneal cavity and in vitro for marrow purging. We first analyzed the expression of the LacZ reporter gene in @entity6 cell lines, normal fibroblasts, and @entity4 cell lines using the adenoviral vector in which the LacZ gene is governed by the LP-P promoter (AdLPLacZ) or in which the LacZ gene is governed by the cytomegalovirus ( @entity5 ) promoter (AdCMVLacZ). We found equivalent and high levels of expression of @entity7 ( @entity7 ) by AdLPLacZ and AdCMVLacZ vectors in the @entity6 cell lines as well as in a @entity3 cell line, indicating that the adenoviral vectors infected these cells and expressed their transgenes equally with the LP and @entity5 promoters. Expression of the LacZ gene with the @entity5 vector but not with the LP-P vector was observed in experiments with normal fibroblasts, indicating that the vectors infected the cells, but that the LP-P was not active within them. In hematopoietic cells such as U937 cells, no measurable @entity7 activity was detected in cells infected either by AdLPLacZ or by AdCMVLacZ, indicating that the adenoviral vectors were not infecting the cells. Although @entity7 activity was observed in fresh ascitic @entity1 cells after infection with adenoviral vectors containing @entity5 or the LP promoters, @entity7 activity was detected in a portion of a biopsy of normal peritoneum when the tissues were exposed to the AdCMVLacZ vector, but not when tissues were exposed to the AdLPLacZ vector. These results suggest that the transcription of therapeutic genes in cells infected by the AdLP vectors would be restricted to LP expression-positive @entity1 cells but would not be seen in the normal mesothelial cells of the peritoneal cavity. This possibility implies that adenoviral vectors carrying therapeutic genes driven by the LP-P would be of use for the @entity1 .

title: Use of XXXX promoter to develop an adenoviral system that confers transgene expression in @entity1 cells but not in normal mesothelial cells.

answer: @entity8


abstract: BACKGROUND: In @entity0 with acute @entity1 , hyperglycaemia has been retrospectively associated with negative outcome. There is an ongoing discussion as to which treatment algorithm, if any, provides the most effective prospective intervention. Here we test the safety and feasibility of an intravenous insulin-only infusion protocol designed for pragmatic routine clinical use. METHODS: 40 @entity1 @entity0 with onset <24 h ago, admitted to our @entity1 unit, were randomized either to the study regimen (50 IU insulin in 50 ml 0.9% saline solution applied intravenously via a perfusor pump), with the aim of reaching and maintaining blood @entity2 levels between 4.44 mmol/l (80 mg/dl) and 6.11 mmol/l (110 mg/dl), or were treated with insulin subcutaneously if concentrations were above 11.10 mmol/l (200 mg/dl). Treatment was continued for 5 days. Primary outcome was the number of hypoglycaemic (<3.33 mmol/l; <60 mg/dl) and severe hyperglycaemic (>16.65 mmol/l; >300 mg/dl) events. RESULTS: Hypoglycaemic events were significantly more common in @entity0 treated intensively (total n = 25; incidence rate ratio, @entity3 = 5.3; 95% CI = 1.2-22.4; p < 0.05). Symptomatic events were rare (total n = 5). Severe hyperglycaemia was associated with conventional treatment ( @entity3 = 4.9; 95% CI = 1.5-15.9; p < 0.05). Though those treated intensively attained near-normoglycaemic levels quicker and had significantly lower blood @entity2 levels over the study period (6.49 +/- 2.19 mmol/l vs. 8.01 +/- 3.06 mmol/l; 95% CI = -1.78 to -1.28, p < 0.0005), treatment imposes considerable strain on both @entity0 and caregivers. CONCLUSIONS: The intensive intravenous insulin infusion protocol effectively lowers blood @entity2 levels with an increased risk of manageable hypoglycaemic events. However, a highly motivated and trained staff seems essential, limiting feasibility outside of specialty care settings.

title: Pragmatic management of hyperglycaemia in acute XXXX : safety and feasibility of intensive intravenous insulin treatment.

answer: @entity1


abstract: BACKGROUND: @entity8 ( @entity8 ) are @entity5 which can result in a variety of @entity1 . @entity11 is inherited as an autosomal-dominant trait. There is one study in the literature which reports statistical evidence for anticipation in familial @entity8 . METHODS: We reevaluated the clinical course of the disease and performed molecular analyses in a previously described three-generation @entity8 family with apparent anticipation. RESULTS: Disease started at a younger age in each generation, strongly suggesting anticipation. The @entity0 in generation I showed no clinical symptoms by the age of 68, whereas his son became wheelchair-bound at the age of 43 due to an intramedullary cavernous @entity3 at the thoracolumbar transition of the spinal cord. The @entity0 in generation III had a pons @entity2 at the age of 11 due to a large brainstem cavernoma. The @entity2 caused @entity7 and @entity4 , persisting as @entity9 . Sequencing of @entity10 identified a novel frameshift mutation in exon 15 ( @entity12 or @entity13 ) which cosegregated with the phenotype. Flow-FISH analysis of granulocyte and lymphocyte telomere length showed that telomeres were longest in the youngest affected family member. CONCLUSIONS: We could not find any evidence for either of the two currently known molecular mechanisms for genetic anticipation (i.e., expansion of repetitive DNA elements or progressive @entity6 ) in this family. However, the family presented here raises the important question whether surveillance of @entity8 families with gradient-echo MRI should not only include the cerebrum, but the spinal cord as well.

title: Novel XXXX mutation and no molecular evidence of anticipation in a family with cerebral and spinal cavernous malformations.

answer: @entity10


abstract: OBJECTIVE: We determined the autoantibody profile in @entity7 ( @entity7 ) and examined the distribution of thyroid-related autoantibodies in other @entity4 . METHODS: We tested sera from 234 @entity0 with @entity10 ( @entity10 ), 130 with @entity9 ( @entity9 ), 249 with other @entity4 , and 50 healthy controls by enzyme-linked immunosorbent assay or radioimmunoassay. RESULTS: Autoantibodies except TSH receptor antibody (Ab), anti-thyroglobulin (Tg) Ab and @entity12 ( @entity12 ) Ab were not significantly prevalent in @entity0 with @entity7 despite a significantly high elevation of thyroid-related Ab. Significant prevalence of autoantibodies related to @entity7 was observed in type 1 @entity1 @entity0 . Elevation of anti-Tg Ab was seen in @entity0 with @entity11 ( @entity11 ) and @entity3 ( @entity3 ), and anti- @entity12 Ab was elevated in @entity0 with @entity11 . Although the prevalence of anti- @entity5 receptor Ab and @entity6 ( @entity6 )- related Ab was significant in @entity3 , primary Sj  gren's syndrome (pSS)-related Ab were also found in both @entity2 . In @entity8 ( @entity8 ) @entity0 , thyroid-related Ab and pSS-related Ab were detected in both @entity8 groups, although @entity6 -related Ab were limited to the anti-muscle specific kinase Ab-positive @entity8 @entity0 . In @entity0 with connective tissue diseases, anti- Tg Ab and anti- @entity12 Ab were significantly prevalent. CONCLUSION: Thyroid-related Ab were significantly elevated in all @entity4 . Conversely, the elevations of Ab were not significant in the @entity0 with @entity7 , suggesting a close relationship between @entity7 and other immune-mediated diseases.

title: Prevalence of interrelated autoantibodies in thyroid diseases and XXXX .

answer: @entity4


abstract: OBJECTIVE: To examine morbidity, mortality, conversion rates, and disease recurrence after laparoscopic resection of complicated and uncomplicated @entity2 in a single center. SUMMARY BACKGROUND DATA: In contrast to @entity1 , there are few large studies of laparoscopic or open resection for @entity2 . METHODS: This study represents a retrospective analysis of a prospectively collected database of all laparoscopic resections for uncomplicated and complicated @entity4 from a single center. RESULTS: Five hundred @entity0 (305 female) were identified (median age 58; range, 26-89). Recurrent @entity4 was the most common indication for surgery (77%), followed by perforation (10%) and fistulation (9%). Median operating time was 120 minutes (range, 45-285) and median length of hospital stay was 4 (2-33) days. The @entity5 was routinely mobilized. There was 1 (0.2%) 30-day and in-hospital death and 55 (11%) @entity0 had major morbidity after the procedure. Conversion to an open operation was performed in 14 (2.8%) cases. Dense adhesions were the most common cause for conversion (6 @entity0 ). Among @entity0 with complicated @entity4 , the conversion rate was 5.3%, whereas for those with uncomplicated disease, it was 2.1% (P = ns). Operating time and length of hospital stay do not differ significantly between @entity0 with complicated and uncomplicated @entity4 . The conversion rate has come down from 8% for the first 100 cases to 1.5% for the last 400 cases (P = 0.002). To our knowledge, there have been no cases of recurrent @entity4 . CONCLUSIONS: Laparoscopic resection even in complicated cases of @entity4 is safe and effective. It can be achieved with short operating times and length of stay in conjunction with very low rates of morbidity and mortality. Adherence to surgical principles including routine mobilization of the @entity5 and @entity3 onto the rectum may explain the absence of disease recurrence in our experience.

title: Laparoscopic resection for XXXX : follow-up of 500 consecutive @entity0 .

answer: @entity2


abstract: OBJECTIVE: To examine morbidity, mortality, conversion rates, and disease recurrence after laparoscopic resection of complicated and uncomplicated @entity2 in a single center. SUMMARY BACKGROUND DATA: In contrast to @entity1 , there are few large studies of laparoscopic or open resection for @entity2 . METHODS: This study represents a retrospective analysis of a prospectively collected database of all laparoscopic resections for uncomplicated and complicated @entity4 from a single center. RESULTS: Five hundred @entity0 (305 female) were identified (median age 58; range, 26-89). Recurrent @entity4 was the most common indication for surgery (77%), followed by perforation (10%) and fistulation (9%). Median operating time was 120 minutes (range, 45-285) and median length of hospital stay was 4 (2-33) days. The @entity5 was routinely mobilized. There was 1 (0.2%) 30-day and in-hospital death and 55 (11%) @entity0 had major morbidity after the procedure. Conversion to an open operation was performed in 14 (2.8%) cases. Dense adhesions were the most common cause for conversion (6 @entity0 ). Among @entity0 with complicated @entity4 , the conversion rate was 5.3%, whereas for those with uncomplicated disease, it was 2.1% (P = ns). Operating time and length of hospital stay do not differ significantly between @entity0 with complicated and uncomplicated @entity4 . The conversion rate has come down from 8% for the first 100 cases to 1.5% for the last 400 cases (P = 0.002). To our knowledge, there have been no cases of recurrent @entity4 . CONCLUSIONS: Laparoscopic resection even in complicated cases of @entity4 is safe and effective. It can be achieved with short operating times and length of stay in conjunction with very low rates of morbidity and mortality. Adherence to surgical principles including routine mobilization of the @entity5 and @entity3 onto the rectum may explain the absence of disease recurrence in our experience.

title: Laparoscopic resection for @entity2 : follow-up of 500 consecutive XXXX .

answer: @entity0


abstract: PURPOSE: The purpose of this study was to assess the role of in vivo confocal microscopy in cases of @entity1 presenting with a deep stromal infiltrate. DESIGN: Retrospective, noncomparative case series. METHODS: We reviewed the medical, microbiologic, and histopathologic data of 6 @entity0 , whose clinical presentation was characterized by deep stromal or multifocal endothelial lesions. These @entity0 were subjected to in vivo confocal microscopy on the day of presentation. All the @entity0 underwent therapeutic penetrating keratoplasty. The excised corneal buttons were bisected and subjected to microbiologic and histopathologic examinations. RESULTS: Microbiologic and/or histopathologic examination proved that the @entity2 in all the 6 @entity0 was caused by filamentous fungi. Five corneal buttons were positive for the fungus on histopathologic examination. Four specimens grew out fungus on microbiologic examination. In 5 (83%) cases, confocal microscopy revealed double-walled, septate, linear branching structures resembling fungal filaments. CONCLUSIONS: In vivo confocal microscopy can be a useful diagnostic tool in @entity0 presenting with deep stromal lesions.

title: Role of confocal microscopy in deep XXXX .

answer: @entity1


abstract: BACKGROUND: It has been suggested that @entity0 with @entity5 of the Alzheimer type have @entity1 , and thus, may have similar sensorimotor problems as @entity0 with @entity1 from @entity3 . Whether the similarity extends to balance control is unknown. One distinguishing feature of @entity2 in @entity3 is difficulty with changing postural set in terms of adapting the amplitude of leg muscle activity as a function of support condition. We, therefore, tested whether @entity0 with @entity4 without @entity1 would show a similar problem in changing postural set as @entity0 with @entity3 . METHODS: The ability to quickly change postural set was measured by comparing leg muscle activity under two conditions of support (free stance, versus grasping a frame, or sitting) during backward surface translations, during toes up surface rotations, and during @entity6 to toes. Results were compared among 12 healthy adults, 8 nondemented @entity3 @entity0 on their usual dose of medication, and 11 Alzheimer @entity0 without @entity1 . RESULTS: Subjects with Alzheimer's, but not @entity3 performed similarly to the healthy control subjects. They changed postural set immediately, by suppressing leg muscle activity to low levels when supported. Parkinson subjects did not change postural set immediately. They did not suppress the tibialis anterior in @entity6 to toes when holding, nor the soleus in perturbed sitting as much as the healthy control and Alzheimer subjects in the first trial. Instead, the Parkinson subjects changed set more slowly, over repeated and consecutive trials in both protocols. The onset latencies of soleus responses to backward surface translations and perturbed sitting, as well as tibialis anterior responses to toes up rotations, were the same for all three groups. CONCLUSION: Alzheimer @entity0 without @entity1 , unlike nondemented @entity3 @entity0 , have no difficulty in quickly changing postural set in response to altered support conditions. Our results, therefore, do not support the hypothesis that @entity3 and uncomplicated @entity4 share common postural set problems that may contribute to disordered balance control.

title: Postural set for balance control is normal in Alzheimer's but not in XXXX .

answer: @entity3


abstract: PURPOSE: A prospective, nonrandomized, comparative study was carried out to investigate levels of anti-Helicobacter pylori-specific IgG antibodies in the @entity4 and serum of @entity0 with @entity2 ( @entity2 ), exfoliation syndrome [ @entity5 ( @entity5 )], and with normotensive @entity1 @entity0 , who served as controls. METHODS: Aqueous humor was aspirated at the beginning of @entity3 surgery from 50 eyes of 50 @entity0 with @entity2 , with @entity5 and at the beginning of phacoemulsification @entity1 surgery from controls. Serum samples were obtained. Anti-H. pylori IgG concentration in the @entity4 and serum was measured by means of enzyme linked immunosorbent assay. RESULTS: Serum analysis of anti-H. pylori IgG antibodies revealed statistically significant difference between @entity2 and @entity5 (52.26+/-52.51 vs. 25.22+/-35.27, P=0.01). Also, the difference between @entity2 and controls was statistically significant (54.05+/-55.04 vs. 33.83+/-41.73, P=0.04). However, on comparing @entity5 with the control group, the difference was statistically insignificant (P=0.12). The mean concentration of anti-H. pylori IgG antibodies in @entity4 of @entity0 in @entity2 and controls were not statistically different (3.93+/-5.14 vs. 2.65+/-2.87, respectively, P=0.73). The mean concentration of anti-H. pylori IgG antibodies in @entity4 of @entity0 in @entity5 and controls were not statistically different (8.87+/-30.25 vs. 2.65+/-2.87, respectively, P=0.83). There was also no statistical difference of IgG levels between @entity2 and @entity5 (3.93+/-5.14 vs. 8.87+/-30.25, respectively, P=0.87). CONCLUSIONS: The levels of anti-H. pylori IgG titers in sera of individuals with @entity2 were significantly higher compared with @entity5 and control groups. We support the hypothesis of the role of anti-H. pylori antibodies in causative mechanism for @entity2 . We could not find a significant link between the anti-H. pylori IgG antibodies and the @entity5 .

title: Helicobacter pylori IgG antibodies in XXXX and serum of subjects with primary open angle and @entity5 in a South Indian population.

answer: @entity4


abstract: PURPOSE: A prospective, nonrandomized, comparative study was carried out to investigate levels of anti-Helicobacter pylori-specific IgG antibodies in the @entity4 and serum of @entity0 with @entity2 ( @entity2 ), exfoliation syndrome [ @entity5 ( @entity5 )], and with normotensive @entity1 @entity0 , who served as controls. METHODS: Aqueous humor was aspirated at the beginning of @entity3 surgery from 50 eyes of 50 @entity0 with @entity2 , with @entity5 and at the beginning of phacoemulsification @entity1 surgery from controls. Serum samples were obtained. Anti-H. pylori IgG concentration in the @entity4 and serum was measured by means of enzyme linked immunosorbent assay. RESULTS: Serum analysis of anti-H. pylori IgG antibodies revealed statistically significant difference between @entity2 and @entity5 (52.26+/-52.51 vs. 25.22+/-35.27, P=0.01). Also, the difference between @entity2 and controls was statistically significant (54.05+/-55.04 vs. 33.83+/-41.73, P=0.04). However, on comparing @entity5 with the control group, the difference was statistically insignificant (P=0.12). The mean concentration of anti-H. pylori IgG antibodies in @entity4 of @entity0 in @entity2 and controls were not statistically different (3.93+/-5.14 vs. 2.65+/-2.87, respectively, P=0.73). The mean concentration of anti-H. pylori IgG antibodies in @entity4 of @entity0 in @entity5 and controls were not statistically different (8.87+/-30.25 vs. 2.65+/-2.87, respectively, P=0.83). There was also no statistical difference of IgG levels between @entity2 and @entity5 (3.93+/-5.14 vs. 8.87+/-30.25, respectively, P=0.87). CONCLUSIONS: The levels of anti-H. pylori IgG titers in sera of individuals with @entity2 were significantly higher compared with @entity5 and control groups. We support the hypothesis of the role of anti-H. pylori antibodies in causative mechanism for @entity2 . We could not find a significant link between the anti-H. pylori IgG antibodies and the @entity5 .

title: Helicobacter pylori IgG antibodies in @entity4 and serum of subjects with primary open angle and XXXX in a South Indian population.

answer: @entity5


abstract: Seven-valent pneumococcal conjugate vaccination commenced in 2001 for Australian indigenous @entity0 . Pneumococcal carriage surveillance detected substantial replacement with nonvaccine serotypes and a cluster of serotype 1 carriage. Our aim was to review @entity2 serotype 1 carriage and @entity1 ( @entity1 ) data for this population and to analyze serotype 1 isolates. Carriage data were collected between 1992 and 2004 in the Darwin region, one of the five regions in the Northern Territory. Carriage data were also collected in 2003 and 2005 from four regions in the Northern Territory. Twenty-six cases of serotype 1 @entity1 were reported from 1994 to 2007 in the Northern Territory. Forty-four isolates were analyzed by BOX typing and 11 by multilocus sequence typing. In the Darwin region, 26 @entity0 were reported carrying serotype 1 (ST227) in 2002 but not during later surveillance. Scattered cases of serotype 1 carriage were noted in two other regions. Cocolonization of serotype 1 with other pneumococcal serotypes was common (34% serotype 1-positive swabs). In conclusion, pneumococcal carriage studies detected intermittent serotype 1 carriage and an ST227 cluster in @entity0 in indigenous communities in the Northern Territory of Australia. There was no apparent increase in serotype 1 @entity1 during this time. The rate of serotype 1 cocolonization with other pneumococcal serotypes suggests that carriage of this serotype may be underestimated.

title: Age-specific cluster of cases of serotype 1 XXXX carriage in remote indigenous communities in Australia.

answer: @entity2


abstract: @entity2 ( @entity2 ) are common pediatric rhythm disorders requiring comprehensive laboratory evaluation. Although usually idiopathic, implying a benign character and favorable prognosis, the initial clinical approach is still not established in all cases. Considering their prognostic significance, exercise-induced (precipitated or aggravated) @entity2 usually require additional diagnostics, treatment, and follow-up. A number of reports have presented experimental and clinical evidence that increased sympathetic activity can initiate, or at least facilitate, @entity2 . Recent data highlight the relationship between exercise-induced @entity3 ( @entity3 ) and the long-term risk of @entity1 . The aim of this study was to assess the utility of heart rate variability (HRV) analysis as a noninvasive method for estimating autonomic nervous activity in @entity0 with exercise induced @entity3 . The study included 42 @entity0 with @entity3 , who were divided into two groups: @entity0 with exercise induced (precipitated or aggravated) @entity3 and @entity0 with exercised-suppressed @entity3 . Time-domain HRV parameters were analyzed from 24-h ambulatory electrocardiography recordings, and the majority of @entity0 underwent an exercise stress test using the McMaster protocol. The results of this study showed no significant changes in parasympathetic index, i.e., the square root of the mean of the sum of the squares of the differences between adjacent NN intervals (the length between two successive heartbeats) between the groups examined. On the other hand, we observed diminished time-domain values for the standard deviation of all adjacent NN intervals, as well as diminished time-domain values for standard deviation of the averages of NN intervals in all 5-min segments in the group of @entity0 with exercise-induced @entity3 , implicating increased sympathetic activity in such individuals. HRV analysis could be a helpful diagnostic method, giving useful information regarding cardiac autonomic control in some @entity0 with exercise-induced @entity3 .

title: Heart rate variability in @entity0 with exercise-induced idiopathic XXXX .

answer: @entity2


abstract: @entity2 ( @entity2 ) are common pediatric rhythm disorders requiring comprehensive laboratory evaluation. Although usually idiopathic, implying a benign character and favorable prognosis, the initial clinical approach is still not established in all cases. Considering their prognostic significance, exercise-induced (precipitated or aggravated) @entity2 usually require additional diagnostics, treatment, and follow-up. A number of reports have presented experimental and clinical evidence that increased sympathetic activity can initiate, or at least facilitate, @entity2 . Recent data highlight the relationship between exercise-induced @entity3 ( @entity3 ) and the long-term risk of @entity1 . The aim of this study was to assess the utility of heart rate variability (HRV) analysis as a noninvasive method for estimating autonomic nervous activity in @entity0 with exercise induced @entity3 . The study included 42 @entity0 with @entity3 , who were divided into two groups: @entity0 with exercise induced (precipitated or aggravated) @entity3 and @entity0 with exercised-suppressed @entity3 . Time-domain HRV parameters were analyzed from 24-h ambulatory electrocardiography recordings, and the majority of @entity0 underwent an exercise stress test using the McMaster protocol. The results of this study showed no significant changes in parasympathetic index, i.e., the square root of the mean of the sum of the squares of the differences between adjacent NN intervals (the length between two successive heartbeats) between the groups examined. On the other hand, we observed diminished time-domain values for the standard deviation of all adjacent NN intervals, as well as diminished time-domain values for standard deviation of the averages of NN intervals in all 5-min segments in the group of @entity0 with exercise-induced @entity3 , implicating increased sympathetic activity in such individuals. HRV analysis could be a helpful diagnostic method, giving useful information regarding cardiac autonomic control in some @entity0 with exercise-induced @entity3 .

title: Heart rate variability in XXXX with exercise-induced idiopathic @entity2 .

answer: @entity0


abstract: THE PURPOSE OF THE STUDY was to evaluate interstitial laser photocoagulation for local destruction of @entity4 , with computed tomographic (CT) guidance. MATERIAL AND METHODS: 28 @entity0 (age range from 5 to 48 years) with presumed @entity4 were treated with CT-guided interstitial laser photocoagulation of the nidus. A high power semiconductor diode laser (805 nm) with a 400 microns optical fiber was used. The fiber was introduced into the nidus through a 18-gauge needle. Around the fiber tip, well-defined coagulative necroses from 5 to 9 mm (energy delivery, 400-1000J) were obtained. RESULTS: 27 @entity0 had @entity1 relief, which was effective within 24 hours in 18 @entity0 . One @entity0 had @entity1 recurrence after 6 weeks. The remaining nidus was treated secondarily with complete relief. Treatment was unsuccessful in one @entity0 , and surgical excision was performed. All @entity0 were followed up for more than 1 year, with no sign of recurrence. The only notable complication was a mild @entity3 of the wrist in one @entity0 . @entity2 of the nidus was observed 6-12 months after the procedure. CONCLUSION: Percutaneous interstitial laser photocoagulation of @entity4 seems to be a promising, simple, precise, and minimally invasive alternative to traditional surgical and percutaneous ablations.

title: [Treatment of XXXX using laser photocoagulation. Apropos of 28 cases].

answer: @entity4


abstract: INTRODUCTION: The aim of this work was to study movement control strategies in @entity0 with @entity2 . These strategies were expected to be different from healthy subjects because of deficiencies due to @entity2 (i.e. @entity1 , altered proprioception). METHOD: A kinetic and kinematic analysis was performed in a population of 10 @entity0 with @entity2 and in 11 age-matched control subjects, using an ELITE system and two AMTI force-plates. The different phases of a side step were studied. RESULTS: The timing of the movement was different in the two populations. The postural phase was longer and the monopodal phase was shorter in @entity2 @entity0 when the affected leg was the supporting one than when the sound leg was supporting. Total step duration and landing-stabilization phase duration were longer in @entity2 @entity0 than in healthy subjects. CONCLUSION: This movement analysis method enables to determine and to quantify differences between @entity2 @entity0 and control subjects. Clinical examination cannot identify these differences. Movement analysis methods bring up additional information to usual clinical evaluation scales and could be used for evaluation of the results of total knee arthroplasty.

title: [Methods of shifting body weight in XXXX with knee arthroses].

answer: @entity0


abstract: PURPOSE OF THE STUDY: The relation between patello-femoral instability and @entity3 was identified by Dejour. Trochlear @entity1 , diagnosed on knee lateral Xray when the trochlear groove crosses both femoral condyles (the so-called "crossing sign"), must be corrected to improve patello-femoral stability. However surgery should be related to the severity and the shape of @entity3 , underlining the importance of a reproducible classification. The aim of this study was to establish intra and inter-observer reliability of Dejour's radiographic criteria. MATERIAL: 68 preoperative exact knee profile radiographs were harvested from clinical records of 64 @entity0 who underwent trochleoplasty because of patello-femoral instability and @entity3 . On these 68 views, the crossing sign was identified by the senior surgeon (F.G.) who performed or supervised surgery. METHOD: The 68 radiographs were examined independently by 7 observers (2 juniors, 5 seniors) in order to assess interobserver agreement. Two juniors repeated the observation to test intraobserver agreement. Reproducibility for categorical data (7 shapes of trochlea according to Dejour (3 for @entity1 )) was evaluated by Kappa statistics, and for numerical data (depth and anterior projection of the trochlear groove with respect to anterior femoral cortex) we used the interclass correlation analysis. RESULTS: Two out of the 7 observers rated all the 68 trochleas as dysplastics. The 5 others rated as normal 1 to 6 trochleas out of the 68. None of the 68 trochleas were recognized with the same shape by the 7 examiners. At best, 6 observers agreed on the same shape and for only 12 trochleas. Disagreement was mostly related to mistakes between type I and @entity2 . For trochlear morphology interobserver agreement was slight (Kappa = 0.17) and intraobserver agreement was fair (Kappa = 0.3). The mean prominence of the trochlea was 3 +/- 2.1 mm [-6 to 10], and the mean trochlea depth was 1 +/- 1.9 mm [0 to 11]. These measurements were more reliable since the interclass correlation coefficients were respectively 0.62 and 0.38. The level of experience of the observers had no influence for categorical or numerical data. DISCUSSION: Our results indicated a low interobserver agreement for trochlear shape identification according to Dejour. The most reliable criteria was measurement of the trochlear prominence which was mostly pathological in our series. The "crossing sign" was reliable to diagnose @entity1 since the probability to rate as normal a true @entity4 trochlea was only 3.1 per cent. However, once the @entity1 diagnosed, this classification gave inconsistent results to select the trochlear shape, particularly for type II. To improve reproducibility we propose to diagnose a type II only when 5 millimeters separate the crossings between the medial and lateral condyles. CONCLUSION: We recommend to use anterior projection of the trochlear groove to rate @entity3 and to determine the adequate type of trochleoplasty: elevating of the lateral facet if non prominent or deepening of the groove when prominent.

title: [Reproducibility of the radiographic analysis of XXXX of the femoral trochlea. Intra- and interobserver analysis of 68 knees].

answer: @entity1