abstract: Abstract @entity3 subtype-4 receptors ( @entity7 ) inhibit L-type @entity2 channel currents (ICa) in @entity4 cells (RGCs). Here we identify the signaling pathways involved in @entity7 stimulation leading to suppression of ICa in RGCs. Whole cell patch clamp recordings were made on isolated immunopanned RGCs using barium as a charge carrier to isolate ICa. Application of the selective @entity7 agonist, L-803 (10  nM), reduced ICa by @entity0 %. Pretreatment of cells with pertussis toxin (Gi/o inhibitor) did not prevent the action of L-803, which reduced ICa by 34.7%. To determine the involvement of Gby subunits after @entity7 activation, depolarizing pre-pulse facilitation paradigms were used to remove voltage-dependent inhibition of @entity2 channels. Pre-pulse facilitation did not reverse the inhibitory effects of L-803 on ICa (8.4  vs. 8.8% reductions, ctrl vs. L-803); however, pharmacologic inhibition of Gby reduced ICa suppression by L-803 (23.0%, p<0.05). Inhibition of @entity5 ( @entity6 ; GFX) showed a concentration-dependent effect in preventing the action of L-803 on ICa (1   M GFX, 34.3%; 5   M GFX, 14.6%, p<0.05). When both @entity5 and Gby were inhibited, the effects of L-803 on ICa were blocked (1.8%, p<0.05). These results suggest that @entity7 stimulation modulates RGC @entity2 channels via Gby and @entity5 activation. Since reducing intracellular @entity1 is known to be neuroprotective in RGCs, modulating these @entity7 signaling pathways may provide insights to the discovery of unique therapeutic targets to reduce intracellular @entity1 levels in RGCs.

title: @entity3 receptor subtype 4 modulates L-type XXXX channels via Gby and @entity5 signaling in rat @entity4 cells.

answer: @entity2


abstract: Abstract @entity3 subtype-4 receptors ( @entity7 ) inhibit L-type @entity2 channel currents (ICa) in @entity4 cells (RGCs). Here we identify the signaling pathways involved in @entity7 stimulation leading to suppression of ICa in RGCs. Whole cell patch clamp recordings were made on isolated immunopanned RGCs using barium as a charge carrier to isolate ICa. Application of the selective @entity7 agonist, L-803 (10  nM), reduced ICa by @entity0 %. Pretreatment of cells with pertussis toxin (Gi/o inhibitor) did not prevent the action of L-803, which reduced ICa by 34.7%. To determine the involvement of Gby subunits after @entity7 activation, depolarizing pre-pulse facilitation paradigms were used to remove voltage-dependent inhibition of @entity2 channels. Pre-pulse facilitation did not reverse the inhibitory effects of L-803 on ICa (8.4  vs. 8.8% reductions, ctrl vs. L-803); however, pharmacologic inhibition of Gby reduced ICa suppression by L-803 (23.0%, p<0.05). Inhibition of @entity5 ( @entity6 ; GFX) showed a concentration-dependent effect in preventing the action of L-803 on ICa (1   M GFX, 34.3%; 5   M GFX, 14.6%, p<0.05). When both @entity5 and Gby were inhibited, the effects of L-803 on ICa were blocked (1.8%, p<0.05). These results suggest that @entity7 stimulation modulates RGC @entity2 channels via Gby and @entity5 activation. Since reducing intracellular @entity1 is known to be neuroprotective in RGCs, modulating these @entity7 signaling pathways may provide insights to the discovery of unique therapeutic targets to reduce intracellular @entity1 levels in RGCs.

title: XXXX receptor subtype 4 modulates L-type @entity2 channels via Gby and @entity5 signaling in rat @entity4 cells.

answer: @entity3


abstract: Abstract @entity3 subtype-4 receptors ( @entity7 ) inhibit L-type @entity2 channel currents (ICa) in @entity4 cells (RGCs). Here we identify the signaling pathways involved in @entity7 stimulation leading to suppression of ICa in RGCs. Whole cell patch clamp recordings were made on isolated immunopanned RGCs using barium as a charge carrier to isolate ICa. Application of the selective @entity7 agonist, L-803 (10  nM), reduced ICa by @entity0 %. Pretreatment of cells with pertussis toxin (Gi/o inhibitor) did not prevent the action of L-803, which reduced ICa by 34.7%. To determine the involvement of Gby subunits after @entity7 activation, depolarizing pre-pulse facilitation paradigms were used to remove voltage-dependent inhibition of @entity2 channels. Pre-pulse facilitation did not reverse the inhibitory effects of L-803 on ICa (8.4  vs. 8.8% reductions, ctrl vs. L-803); however, pharmacologic inhibition of Gby reduced ICa suppression by L-803 (23.0%, p<0.05). Inhibition of @entity5 ( @entity6 ; GFX) showed a concentration-dependent effect in preventing the action of L-803 on ICa (1   M GFX, 34.3%; 5   M GFX, 14.6%, p<0.05). When both @entity5 and Gby were inhibited, the effects of L-803 on ICa were blocked (1.8%, p<0.05). These results suggest that @entity7 stimulation modulates RGC @entity2 channels via Gby and @entity5 activation. Since reducing intracellular @entity1 is known to be neuroprotective in RGCs, modulating these @entity7 signaling pathways may provide insights to the discovery of unique therapeutic targets to reduce intracellular @entity1 levels in RGCs.

title: @entity3 receptor subtype 4 modulates L-type @entity2 channels via Gby and XXXX signaling in rat @entity4 cells.

answer: @entity5


abstract: Abstract @entity3 subtype-4 receptors ( @entity7 ) inhibit L-type @entity2 channel currents (ICa) in @entity4 cells (RGCs). Here we identify the signaling pathways involved in @entity7 stimulation leading to suppression of ICa in RGCs. Whole cell patch clamp recordings were made on isolated immunopanned RGCs using barium as a charge carrier to isolate ICa. Application of the selective @entity7 agonist, L-803 (10  nM), reduced ICa by @entity0 %. Pretreatment of cells with pertussis toxin (Gi/o inhibitor) did not prevent the action of L-803, which reduced ICa by 34.7%. To determine the involvement of Gby subunits after @entity7 activation, depolarizing pre-pulse facilitation paradigms were used to remove voltage-dependent inhibition of @entity2 channels. Pre-pulse facilitation did not reverse the inhibitory effects of L-803 on ICa (8.4  vs. 8.8% reductions, ctrl vs. L-803); however, pharmacologic inhibition of Gby reduced ICa suppression by L-803 (23.0%, p<0.05). Inhibition of @entity5 ( @entity6 ; GFX) showed a concentration-dependent effect in preventing the action of L-803 on ICa (1   M GFX, 34.3%; 5   M GFX, 14.6%, p<0.05). When both @entity5 and Gby were inhibited, the effects of L-803 on ICa were blocked (1.8%, p<0.05). These results suggest that @entity7 stimulation modulates RGC @entity2 channels via Gby and @entity5 activation. Since reducing intracellular @entity1 is known to be neuroprotective in RGCs, modulating these @entity7 signaling pathways may provide insights to the discovery of unique therapeutic targets to reduce intracellular @entity1 levels in RGCs.

title: @entity3 receptor subtype 4 modulates L-type @entity2 channels via Gby and @entity5 signaling in rat XXXX cells.

answer: @entity4


abstract: This article is part of a Special Issue (" @entity0 and cognition"). @entity2 have repeatedly been shown to influence a wide array of @entity1 , which in rodents are predominantly olfactory-mediated. @entity2 are involved in social behavior at multiple levels of processing, from the detection and integration of socially relevant olfactory information to more complex @entity1 , including social preferences, aggression and dominance, and learning and memory for social stimuli (e.g. social recognition and social learning). Three @entity2 receptors (ERs), @entity3 , @entity4 , and the @entity5 ( @entity5 ), differently affect these behaviors. Social recognition, @entity1 , and sexual preferences and mate choice, all requiring the integration of socially related olfactory information, seem to primarily involve @entity3 , with @entity4 playing a lesser, modulatory role. In contrast, social learning consistently responds differently to @entity2 manipulations than other @entity1 . This suggests differential ER involvement in brain regions important for specific @entity1 , such as the ventromedial and medial preoptic nuclei of the hypothalamus in social preferences and aggression, the medial amygdala and hippocampus in social recognition, and the prefrontal cortex and hippocampus in social learning. While the long-term effects of @entity3 and @entity4 on social behavior have been extensively investigated, our knowledge of the rapid, non-genomic, effects of @entity2 is more limited and suggests that they may mediate some @entity1 (e.g. social learning) differently from long-term effects. Further research is required to compare ER involvement in regulating social behavior in male and female animals, and to further elucidate the roles of the more recently described G protein-coupled ERs, both the @entity5 and the Gq-mER.

title: XXXX involvement in social behavior in rodents: Rapid and long-term actions.

answer: @entity2


abstract: BACKGROUND: @entity7 ( @entity7 ) is a rare @entity1 due to @entity8 mutations. @entity7 @entity0 suffer from many @entity4 , dominated clinically by defective ventilatory automatisms. From birth, the life of @entity7 @entity0 depends on ventilatory support during sleep, involving a high burden of care. Whether or not this impairs the quality of life of these @entity0 during adulthood remains unknown. METHODS: We applied the medical outcome study short form-36 (SF-36) to 12 @entity7 @entity0 aged 15-33 (9 @entity0 ) at the time of their passage from pediatric to adult care. Scores for the SF-36 dimensions were compared to the age- and gender-matched French reference population after transformation into standardized Z-scores. The SF-36 physical component summary score (PCS) and @entity3 ( @entity3 ) were compared to American reference values. RESULTS: Median Z-scores were significantly different from zero for PF (physical functioning, p   =   0.020) and GH (general health perception, p   =   0.0342) and for PCS (p   =   0.020). The other physical dimensions ( @entity5 , role limitation due to physical function; BP, @entity2 ) and the mental dimensions (VT, vitality; SF, social functioning; RE, role limitation due to emotional function; @entity6 , mental health) and @entity3 were not altered. CONCLUSIONS: We conclude that, despite the physical constraints imposed by @entity7 and its anxiogenic nature, this disease is associated with an impairment of health-related quality of life in young adults that remains moderate. Whatever the underlying explanations, these results convey hope to parents with a @entity0 diagnosed with @entity7 and for @entity0 themselves.

title: Health-related quality of life in young adults with XXXX due to @entity8 mutations: a cross-sectional study.

answer: @entity7


abstract: BACKGROUND: @entity7 ( @entity7 ) is a rare @entity1 due to @entity8 mutations. @entity7 @entity0 suffer from many @entity4 , dominated clinically by defective ventilatory automatisms. From birth, the life of @entity7 @entity0 depends on ventilatory support during sleep, involving a high burden of care. Whether or not this impairs the quality of life of these @entity0 during adulthood remains unknown. METHODS: We applied the medical outcome study short form-36 (SF-36) to 12 @entity7 @entity0 aged 15-33 (9 @entity0 ) at the time of their passage from pediatric to adult care. Scores for the SF-36 dimensions were compared to the age- and gender-matched French reference population after transformation into standardized Z-scores. The SF-36 physical component summary score (PCS) and @entity3 ( @entity3 ) were compared to American reference values. RESULTS: Median Z-scores were significantly different from zero for PF (physical functioning, p   =   0.020) and GH (general health perception, p   =   0.0342) and for PCS (p   =   0.020). The other physical dimensions ( @entity5 , role limitation due to physical function; BP, @entity2 ) and the mental dimensions (VT, vitality; SF, social functioning; RE, role limitation due to emotional function; @entity6 , mental health) and @entity3 were not altered. CONCLUSIONS: We conclude that, despite the physical constraints imposed by @entity7 and its anxiogenic nature, this disease is associated with an impairment of health-related quality of life in young adults that remains moderate. Whatever the underlying explanations, these results convey hope to parents with a @entity0 diagnosed with @entity7 and for @entity0 themselves.

title: Health-related quality of life in young adults with @entity7 due to XXXX mutations: a cross-sectional study.

answer: @entity8


abstract: UNASSIGNED: In decision-making, an immediate reward is usually preferred to a delayed reward, even if the latter is larger. We tested whether the hippocampus is necessary for this form of temporal discounting, and for vicarious @entity2 at the decision point. @entity0 were trained on a recently developed, adjustable delay-discounting task (Papale et al. (2012) Cogn Affect Behav Neurosci 12:513-526), which featured a choice between a small, nearly immediate reward, and a larger, delayed reward. @entity0 then received either hippocampus or sham lesions. Animals with @entity1 adjusted the delay for the larger reward to a level similar to that of sham-lesioned animals, suggesting a similar valuation capacity. However, the hippocampus lesion group spent significantly longer investigating the small and large rewards in the first part of the sessions, and were less sensitive to changes in the amount of reward in the large reward maze arm. Both sham- and hippocampus-lesioned @entity0 showed a greater amount of vicarious @entity2 on trials in which the delay was adjusted. In a nonadjusting version of the delay discounting task, animals with @entity1 showed more variability in their preference for a larger reward that was delayed by 10 s compared with sham-lesioned animals. To verify the lesion behaviorally, @entity0 were subsequently trained on a water maze task, and @entity0 with @entity1 were significantly impaired compared with sham-lesioned animals. The findings on the delay discounting tasks suggest that damage to the hippocampus may impair the detection of reward magnitude.    2014 Wiley Periodicals, Inc.

title: Hippocampus, delay discounting, and vicarious XXXX .

answer: @entity2


abstract: BACKGROUND: Endoscopic biliary drainage (EBD) and percutaneous transhepatic biliary drainage (PTBD) are both used to resolve @entity2 before surgery for perihilar @entity1 (PHC). PTBD has been associated with seeding metastases. The aim of this study was to compare overall survival (OS) and the incidence of initial seeding metastases that potentially influence survival in @entity0 with preoperative PTBD versus EBD. METHODS: Between 1991 and 2012, a total of 278 @entity0 underwent preoperative biliary drainage and resection of PHC at 2 institutions in the Netherlands and the United States. Of these, 33 @entity0 were excluded for postoperative mortality. Among the 245 included @entity0 , 88 @entity0 who underwent preoperative PTBD (with or without previous EBD) were compared to 157 @entity0 who underwent EBD only. Survival analysis was done with Kaplan-Meier and Cox regression with propensity score adjustment. RESULTS: Unadjusted median OS was comparable between the PTBD group (35 months) and EBD-only group (41 months; P = 0.26). After adjustment for propensity score, OS between the PTBD group and EBD-only group was similar (hazard ratio, 1.05; 95 % confidence interval, 0.74-1.49; P = 0.80). Seeding metastases in the @entity3 occurred as initial recurrence in 7 @entity0 , including 3 @entity0 (3.4 %) in the PTBD group and 4 @entity0 (2.7 %) in the EBD-only group (P = 0.71). No @entity0 had an initial recurrence in percutaneous catheter tracts. CONCLUSIONS: The present study found no effect of PTBD on survival compared to @entity0 with EBD and no increase in seeding metastases that developed as initial recurrence. These data suggest that PTBD can safely be used in preoperative management of PHC.

title: Percutaneous Preoperative Biliary Drainage for Resectable XXXX : No Association with Survival and No Increase in Seeding Metastases.

answer: @entity1


abstract: Introduction Universal @entity1 vaccination in Sicily was introduced in @entity0 population since 2003, with a rapidly increasing coverage. Aim of the present study was to analyze changes in the epidemiology of @entity1 since the introduction of universal vaccination. Methods The study was performed by analyzing Sicilian administrative/clinical data on @entity1 case notifications and hospitalizations from 2003 to 2012 (ICD-9-CM discharge diagnosis codes 052 and 052.*). MMR+V and V coverage were also calculated for each birth cohort. Moreover, blood samples drawn in 2013/2014 from general population stratified by age were tested for @entity1 antibodies. Results From 2003 to 2012, 15   433 @entity1 cases were notified with a decreasing temporal trend (1.1/1000 population in 2003 to 0.1/1000 in 2012) (P < 0.001). In the same period, a total of 1145 @entity0 were hospitalized with a @entity1 , with a 6-fold reduced risk of hospitalization over time (from 4.8 to 0.8/100   000 population per year; P < 0.001). Varicella vaccination coverage rates increased from 40% (2001 birth cohort) to 85% (2010 birth cohort), and inversely correlated with both notification and hospitalization rates (P < 0.001). Finally, 80.0% of subjects enrolled in the seroepidemiological survey were positive for @entity1 and seroprevalence increased significantly with age in both sexes (P < 0.001). Discussion The results show the impact of @entity0 universal @entity1 vaccination in Sicily. Noteworthy, notifications and hospitalizations for @entity1 have significantly decreased after the introduction of universal vaccination, confirming the effectiveness of the adopted strategy.

title: The impact of ten years of XXXX universal Varicella vaccination in Sicily, Italy (2003-2012).

answer: @entity0


abstract: We present a retrospective audit of all arterial embolectomies performed at the East Glamorgan General Hospital over @entity5 -year period (1980-1990). Eighty-seven @entity0 (47M:40F), mean age 67 years (50-90 years) underwent 95 embolectomies, an incidence consistent with previous studies. There were 17 upper and 71 @entity4 with a mean delay before diagnosis of 29 h (range 1-264 h). In 66% of cases the cause was @entity3 ; 33% received immediate heparinization and 14% prophylactic antibiotics. Surgery was performed by a consultant in 12 and registrars in 75 cases, and under local anaesthesia in 80% and general anaesthesia in 20%. There was no anaesthetist present in 54% of cases. Few pre- or peroperative arteriograms were performed. The 30-day mortality was 45%, with an amputation rate of 15% and an overall postoperative complication rate of 62% with little improvement in these figures over the last 10 years. Factors increasing mortality were: delay before diagnosis, grade of surgeon performing the operation, and inadequate inflow or outflow at operation. Factors found to affect limb salvage rate adversely were a history of @entity2 , although such a history was not recorded in many cases, and lack of immediate preoperative heparinization. Although embolectomy is considered a 'registrar operation', reviewing our results it can be seen that it is an uncommon operation, in our series eight or nine being performed annually. Sometimes inappropriate surgery is performed upon @entity0 in whom severe @entity1 may contraindicate any form of surgical intervention.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX -year experience of arterial embolectomy in a district general hospital.

answer: @entity5


abstract: Intratumoral heterogeneous @entity3 amplification (hetMNA) is an unusual event in @entity2 with unascertained biological and clinical implications. Diagnosis is based on the detection of @entity3 amplification surrounded by non-amplified @entity1 cells by fluorescence in situ hybridization (FISH). To better define the genetic features of hetMNA @entity1 , we studied the Spanish cohort of @entity1 by FISH and single nucleotide polymorphism arrays. We compared hetMNA @entity1 with homogeneous MNA (homMNA) and nonMNA @entity1 with 11q deletion (nonMNA w11q-). Of 1091 @entity1 , 28 were hetMNA by FISH. Intratumoral heterogeneity of 1p, 2p, 11q and 17q was closely associated with hetMNA @entity1 when analyzing different pieces for each case. For chromosome 2, 16 cases showed 2p intact, 4 focal gain at 2p24.3 and 8 MNA. The lengths of the smallest regions of overlap (SROs) for 2p gains and 1p deletions were between the SRO lengths observed in homMNA and nonMNA w11q- @entity1 . Co-occurrence of 11q- and +17q was frequently found with the largest SROs for both aberrations. The evidence for and frequency of different genetic subpopulations representing a hallmark of the hetMNA subgroup of NB indicates, on one hand, the presence of a considerable genetic instability with different SRO of either gains and losses compared with those of the other NB groups and highlights and, on the other hand, the need for multiple sampling from distant and macroscopically and microscopically distinct @entity1 areas. Narrowing down the different SRO for both deletions and gains in NB groups would be crucial to pinpointing the candidate gene(s) and the critical gene dosage with prognostic and therapeutic significance. This complexity of segmental chromosomal aberration patterns reinforces the necessity for a larger cohort study using FISH and pangenomic techniques to develop a suitable therapeutic strategy for these @entity0 .

title: Comparative genetic study of intratumoral heterogenous XXXX amplified @entity2 versus aggressive genetic profile neuroblastic tumors.

answer: @entity3


abstract: Intratumoral heterogeneous @entity3 amplification (hetMNA) is an unusual event in @entity2 with unascertained biological and clinical implications. Diagnosis is based on the detection of @entity3 amplification surrounded by non-amplified @entity1 cells by fluorescence in situ hybridization (FISH). To better define the genetic features of hetMNA @entity1 , we studied the Spanish cohort of @entity1 by FISH and single nucleotide polymorphism arrays. We compared hetMNA @entity1 with homogeneous MNA (homMNA) and nonMNA @entity1 with 11q deletion (nonMNA w11q-). Of 1091 @entity1 , 28 were hetMNA by FISH. Intratumoral heterogeneity of 1p, 2p, 11q and 17q was closely associated with hetMNA @entity1 when analyzing different pieces for each case. For chromosome 2, 16 cases showed 2p intact, 4 focal gain at 2p24.3 and 8 MNA. The lengths of the smallest regions of overlap (SROs) for 2p gains and 1p deletions were between the SRO lengths observed in homMNA and nonMNA w11q- @entity1 . Co-occurrence of 11q- and +17q was frequently found with the largest SROs for both aberrations. The evidence for and frequency of different genetic subpopulations representing a hallmark of the hetMNA subgroup of NB indicates, on one hand, the presence of a considerable genetic instability with different SRO of either gains and losses compared with those of the other NB groups and highlights and, on the other hand, the need for multiple sampling from distant and macroscopically and microscopically distinct @entity1 areas. Narrowing down the different SRO for both deletions and gains in NB groups would be crucial to pinpointing the candidate gene(s) and the critical gene dosage with prognostic and therapeutic significance. This complexity of segmental chromosomal aberration patterns reinforces the necessity for a larger cohort study using FISH and pangenomic techniques to develop a suitable therapeutic strategy for these @entity0 .

title: Comparative genetic study of intratumoral heterogenous @entity3 amplified XXXX versus aggressive genetic profile neuroblastic tumors.

answer: @entity2


abstract: OBJECTIVE: @entity4 (matUPD(14)) resembles @entity3 ( @entity3 ). As positive effects of @entity2 ( @entity2 ) are observed in individuals with @entity3 , treatment with @entity2 may be useful in individuals with matUPD(14) as well. The aim of this study was to investigate the effect of @entity2 treatment on growth and body composition in @entity0 with matUPD(14). DESIGN: This is a prospective observational study of @entity2 treatment in two @entity0 with matUPD(14) during 2  years, and spontaneous growth in another matUPD(14) @entity0 of similar age. @entity0 : Three @entity0 ( @entity0 A, B and C, aged 8  9, 11  4 and 12  7  years, respectively) with matUPD(14) were included in this study. MEASUREMENTS: @entity0 A and B were treated with @entity2 during 2  years. @entity0 C was not treated with @entity2 , as she was diagnosed at an age at which she attained near-final height. Main outcome measures included height, weight, body proportions, @entity1 , bone age, and DXA scan for body composition. RESULTS: In both treated @entity0 , a considerable increase in height (from -2  3SD and -1  2SD to -1  2SD and -0  6SD, respectively) and @entity1 levels (from +0  1SD and -1  4SD to +1  3SD and +0  9SD, respectively) and, in @entity0 A, a decrease in weight (+1  2 SD to -0  7SD), and improved body composition (fat percentage from 51  5% to 45  4%) were found. Both experienced improved muscle strength. CONCLUSIONS: @entity2 treatment in matUPD(14) cases can show beneficial effects on growth and body composition if started in time. Larger, international studies to determine detailed effectivity and side effects are suggested.

title: Positive effect of @entity2 treatment in XXXX .

answer: @entity4


abstract: OBJECTIVE: @entity4 (matUPD(14)) resembles @entity3 ( @entity3 ). As positive effects of @entity2 ( @entity2 ) are observed in individuals with @entity3 , treatment with @entity2 may be useful in individuals with matUPD(14) as well. The aim of this study was to investigate the effect of @entity2 treatment on growth and body composition in @entity0 with matUPD(14). DESIGN: This is a prospective observational study of @entity2 treatment in two @entity0 with matUPD(14) during 2  years, and spontaneous growth in another matUPD(14) @entity0 of similar age. @entity0 : Three @entity0 ( @entity0 A, B and C, aged 8  9, 11  4 and 12  7  years, respectively) with matUPD(14) were included in this study. MEASUREMENTS: @entity0 A and B were treated with @entity2 during 2  years. @entity0 C was not treated with @entity2 , as she was diagnosed at an age at which she attained near-final height. Main outcome measures included height, weight, body proportions, @entity1 , bone age, and DXA scan for body composition. RESULTS: In both treated @entity0 , a considerable increase in height (from -2  3SD and -1  2SD to -1  2SD and -0  6SD, respectively) and @entity1 levels (from +0  1SD and -1  4SD to +1  3SD and +0  9SD, respectively) and, in @entity0 A, a decrease in weight (+1  2 SD to -0  7SD), and improved body composition (fat percentage from 51  5% to 45  4%) were found. Both experienced improved muscle strength. CONCLUSIONS: @entity2 treatment in matUPD(14) cases can show beneficial effects on growth and body composition if started in time. Larger, international studies to determine detailed effectivity and side effects are suggested.

title: Positive effect of XXXX treatment in @entity4 .

answer: @entity2


abstract: BACKGROUND: Several therapeutic methods have been traditionally used in the treatment of displaced @entity2 ; however, the indication of these treatments is still controversial. The purpose of this study was to compare the medium-term functional results of four methods commonly used in the treatment of @entity2 [conservative treatment, proximal humeral nails (PHN), @entity3 ( @entity3 ), and locking-plates (LP)] taking into consideration the type of @entity1 and the age of the @entity0 . METHODS: We conducted a retrospective cohort study on @entity0 with @entity2 treated with one of the following methods: conservative treatment, PHN, @entity3 , or LP. Functional results were assessed using the absolute Constant score and the disabilities of the arm shoulder and hand score (DASH). The functional outcome was analysed according to age (>= 65 years and <65 years) and @entity1 type (displaced 2-fragment and 3-4-fragment @entity1 ). RESULTS: A total of 113 @entity0 were included in the study, with a mean age of 65.3 SD 15.2 years and average follow-up time of 26.2 SD 12.6 months. @entity0 under 65 years had higher Constant scores when treated with PHN and @entity3 than those treated conservatively (77.2 vs. 54.7, p=0.01 and 74.0 vs. 54.7, p=0.03, respectively). @entity0 above 65 years had higher Constant scores when treated with @entity3 compared to PHN and conservative treatment (68.7 vs. 51.9, p=0.02 and 68.7 vs. 55.9, p=0.029, respectively). In 2-fragment @entity1 , @entity3 resulted in higher Constant scores than conservative treatment (70.4 vs. 53.9, p=0.048). No differences were found in the final outcome between @entity0 treated with LP and those treated conservatively regardless of age, and @entity1 type. There were also no differences between any of the evaluated methods in the treatment of 3-4-fragment @entity1 . CONCLUSION: The use of @entity3 was associated with better functional results than conservative treatment in individuals of all ages, especially in @entity0 with 2-fragment @entity1 ; @entity3 also achieved better functional results than PHN in elderly @entity0 . PHN was superior to conservative treatment in young individuals. No significant differences were found between LP and conservative treatment in any of the analysed categories.

title: Displaced XXXX : When is surgery necessary?

answer: @entity2


abstract: INTRODUCTION: To report the characteristics and anti- @entity3 outcomes of @entity0 who fail to demonstrate @entity3 on intubated urodynamics (UDS). MATERIALS AND METHODS: From 2005 to 2013, the records of @entity0 who underwent UDS prior to artificial urinary sphincter (AUS) were reviewed. The histories, UDS, endoscopies, and anti- @entity3 outcomes of @entity0 who failed to demonstrate @entity3 on intubated UDS were recorded. In our UDS protocol, the urodynamic urethral catheter was removed and the UDS was repeated to elicit @entity3 without the urethral catheter. The valsalva leak point pressure (VLPP) was obtained via the rectal catheter in these @entity0 . RESULTS: All @entity0 were status post radical prostatectomy for @entity2 . Nineteen percent (32) of the study population (169) had non-demonstrable @entity3 on intubated UDS. Mean age at the time of UDS was 62 (range 48-81). All @entity0 demonstrated @entity3 on UDS upon removal of the urethral catheter. Their mean VLPP was 79.3 (SD 36.7). Fifty-six percent (18) of these @entity0 had an @entity4 ( @entity4 ) and 37.5% (12) had a history of radiotherapy treatment, of which six also had an @entity4 . Mean pads per day at the time of UDS was 4.6 (SD 2.9). At a mean follow up of 40.7 months (SD 24.7) from AUS placement, mean pads per day was 0.87 (SD 1.2). CONCLUSIONS: @entity0 who fail to demonstrate @entity3 on intubated UDS have a high rate of @entity4 and history of radiotherapy treatment, which is a known cause for urethra @entity1 and @entity5 . Regardless, these @entity0 can achieve excellent anti- @entity3 outcomes.

title: Characteristics and outcomes of XXXX who fail to leak on intubated urodynamics prior to artificial urinary sphincter placement.

answer: @entity0


abstract: BACKGROUND: The development of a sensitive method for the detection of @entity0 micrometastases in axillary lymph nodes is reported. METHODS: The method was based on amplification of @entity3 mRNA, which encodes a core protein of @entity3 , by a reverse transcriptase-polymerase chain reaction (RT-PCR). Total RNA, which was extracted from a @entity0 cell line (MCF-7), primary @entity0 , and axillary lymph nodes, was subjected to analysis of @entity3 mRNA expression by the RT-PCR method. RESULTS: @entity3 mRNA expression was detected by RT-PCR in MCF-7 cells and in all 15 primary @entity0 but not in control lymph nodes taken from @entity1 with benign diseases. A serial dilution study revealed that @entity3 RT-PCR was a very sensitive method, detecting one MCF-7 cell per 1,000,000 lymph node cells. The detection sensitivity of @entity3 RT-PCR method was compared with that of immunohistochemical staining of an epithelial marker ( @entity3 ). Fifty axillary lymph nodes were obtained from 15 @entity1 with primary @entity0 , and @entity2 in each lymph node was investigated by both methods. The immunohistochemical method demonstrated @entity2 in nine lymph nodes, and @entity3 mRNA was detected in all of them. Of the 41 lymph nodes that were diagnosed to be devoid of @entity2 by immunohistochemistry, @entity3 mRNA was expressed by 6 but not by the other 35, indicating the presence of micrometastases in these 6 lymph nodes that could be detected only by the @entity3 RT-PCR method. CONCLUSIONS: The @entity3 RT-PCR method is more sensitive than immunohistochemistry for the detection of micrometastases in axillary lymph nodes. This new method would be of practical value in selecting the @entity1 at high risk for relapse from those who are histologically lymph node negative.

title: The detection of XXXX micrometastases in axillary lymph nodes by means of reverse transcriptase-polymerase chain reaction.

answer: @entity0


abstract: BACKGROUND: @entity0 is rarely examined in populations of non-European and/or non- @entity5 -American descent, especially in East Asian nations like China. Across two studies, the current investigation sets out to examine the psychometric properties of a Chinese version of a widely used measure of hoarding symptoms-the Savings Inventory Revised (SIR)-and to explore the nature of hoarding beliefs compared to a separate US sample. PROCEDURES: For the first study, 1828 college students in China completed a Mandarin translation of the SIR and measures of @entity1 , @entity2 , and @entity3 . For the second study, 303 students from China and 87 students from the US completed the SIR and a novel hoarding beliefs questionnaire. FINDINGS: In the first study, the Chinese-version of the SIR demonstrated convergent and discriminant validity, as well as internal reliability and preliminary construct validity. However, evidence of temporal stability was modest and requires further investigation. In the second study, the Chinese sample endorsed greater hoarding symptoms and hoarding beliefs compared to the US sample, although only themes of usefulness and @entity4 were associated with hoarding in the Chinese samples, whereas a wider range of beliefs was linked with hoarding in the US sample. In addition, the factor structure of the SIR from the first study did not replicate in second study, suggesting that construct validity of the Chinese SIR may require further corroboration. CONCLUSIONS: The current study established preliminary evidence for the reliability and validity of the Chinese SIR, although future research is needed to confirm its temporal stability and factor structure. Hoarding beliefs in China may be centered on themes of usefulness and @entity4 compared to more heterogeneous themes in the West, suggesting differential manifestations of hoarding tendencies in cultures of non-European and/or non- @entity5 -American descent.

title: A consideration of XXXX symptoms in China.

answer: @entity0


abstract: OBJECTIVE: Significant heterogeneity was highlighted in recent meta-analyses examining exercise effects in @entity2 @entity1 , suggesting that some characteristics may moderate exercise efficacy. The objectives of this meta-analysis are (1) to investigate the influence of methodology, population and intervention studies' characteristics on the association of exercise with @entity5 , quality-of-life (QoL), @entity3 and @entity4 ; (2) to identify exercise intervention characteristics that may maximize efficacy and evaluate the level of evidence about exercise efficacy in @entity0 @entity1 receiving chemotherapy and/or radiotherapy. METHODS: Thirty-three randomized controlled trials (RCTs) evaluating exercise were systematically identified. Population, intervention and methodology characteristics were extracted, coded by two independent investigators and tested as moderators of exercise effect in meta-regression models. Psychological outcomes summary effects were then computed by pooling subgroup of RCTs based on categorized moderators. RESULTS: Indications of selection bias (random sequence generation) or @entity6 (high attrition rate, no intent-to-treat analysis) were associated with better exercise efficacy on QoL, @entity3 and @entity4 . Low total prescribed exercise doses (<140 METs.h) or short duration (<16  weeks) interventions yielded @entity5 , @entity3 and @entity4 reductions whereas higher doses or duration did not. Mind-body interventions led to greater decrease of @entity5 and @entity3 rather than aerobic/resistance-based interventions. CONCLUSION: Our findings indicated that exercise-based interventions may improve @entity5 , QoL, @entity3 and @entity4 , but the evidence mainly rely on studies prone to methodological biases. A prescription of approximately 100 MET.h, e.g. ~120  min of weekly moderate physical exercise for 10  weeks involving mind-body activities, could be advised to maximize @entity5 . Copyright    2014 John Wiley _ Sons, Ltd.

title: Population-, intervention- and methodology-related characteristics of clinical trials impact exercise efficacy during adjuvant therapy for XXXX : a meta-regression analysis.

answer: @entity0


abstract: BACKGROUND: Nasotracheal intubation of @entity0 with @entity2 ( @entity2 ) @entity7 is a challenge for anesthesiologists. Awake fiberoptic intubation (AFOI) is the safest technique in @entity0 with difficult airway. This study compares 3 different techniques of conscious sedation during AFOI in @entity0 with @entity2 @entity7 . METHODS: This study comprised 54 @entity0 , American Society of Anesthesiologists physical status 1, scheduled for @entity2 surgery. The @entity0 were randomly allocated to @entity5 group (n = 18, 0.75  g/kg over 30 seconds), @entity6 group (n = 18, 0.25 mg/kg over 30 seconds), or @entity4 group (n = 18, 0.5 mg/kg over 30 seconds) for conscious sedation. The main determinants affecting the @entity0 's outcome included intubation time, intubation conditions, and @entity0 discomfort, which were determined by scoring system. In addition, postoperative @entity0 dissatisfaction, hemodynamic stability, and @entity3 were measured. RESULTS: Intubation times were significantly different between groups (P < 0.001), where @entity5 had the shortest time (30.28 seconds). Intubation conditions (scores 0-3) were significantly different between groups (P < 0.001).In this context, @entity5 had score 3 (2-3), which was higher compared with 2 (1-3) for @entity6 and 2 (1-2) for @entity4 . @entity0 discomfort score was lowest in the @entity5 group. Hemodynamic stability was maintained within groups, and its changes were not significant (P > 0.05). Postoperative @entity0 's dissatisfaction was observed in 2, 3, and 5 @entity0 in @entity5 , @entity6 , and @entity4 groups, respectively. @entity3 ( @entity1 ) recorded lowest in the @entity5 group. CONCLUSIONS: @entity5 was the best agent for AFOI, because it provided shorter intubation time, better intubation conditions, and least @entity0 's complaint.Iranian registry no.: IRCT 201208061674N4 (www.irct.ir).

title: @entity5 , XXXX , and @entity4 in Awake Nasotracheal Fiberoptic Intubation in Temporomandibular Joint Ankylosis Surgery.

answer: @entity6


abstract: BACKGROUND: Nasotracheal intubation of @entity0 with @entity2 ( @entity2 ) @entity7 is a challenge for anesthesiologists. Awake fiberoptic intubation (AFOI) is the safest technique in @entity0 with difficult airway. This study compares 3 different techniques of conscious sedation during AFOI in @entity0 with @entity2 @entity7 . METHODS: This study comprised 54 @entity0 , American Society of Anesthesiologists physical status 1, scheduled for @entity2 surgery. The @entity0 were randomly allocated to @entity5 group (n = 18, 0.75  g/kg over 30 seconds), @entity6 group (n = 18, 0.25 mg/kg over 30 seconds), or @entity4 group (n = 18, 0.5 mg/kg over 30 seconds) for conscious sedation. The main determinants affecting the @entity0 's outcome included intubation time, intubation conditions, and @entity0 discomfort, which were determined by scoring system. In addition, postoperative @entity0 dissatisfaction, hemodynamic stability, and @entity3 were measured. RESULTS: Intubation times were significantly different between groups (P < 0.001), where @entity5 had the shortest time (30.28 seconds). Intubation conditions (scores 0-3) were significantly different between groups (P < 0.001).In this context, @entity5 had score 3 (2-3), which was higher compared with 2 (1-3) for @entity6 and 2 (1-2) for @entity4 . @entity0 discomfort score was lowest in the @entity5 group. Hemodynamic stability was maintained within groups, and its changes were not significant (P > 0.05). Postoperative @entity0 's dissatisfaction was observed in 2, 3, and 5 @entity0 in @entity5 , @entity6 , and @entity4 groups, respectively. @entity3 ( @entity1 ) recorded lowest in the @entity5 group. CONCLUSIONS: @entity5 was the best agent for AFOI, because it provided shorter intubation time, better intubation conditions, and least @entity0 's complaint.Iranian registry no.: IRCT 201208061674N4 (www.irct.ir).

title: @entity5 , @entity6 , and XXXX in Awake Nasotracheal Fiberoptic Intubation in Temporomandibular Joint Ankylosis Surgery.

answer: @entity4


abstract: BACKGROUND: Nasotracheal intubation of @entity0 with @entity2 ( @entity2 ) @entity7 is a challenge for anesthesiologists. Awake fiberoptic intubation (AFOI) is the safest technique in @entity0 with difficult airway. This study compares 3 different techniques of conscious sedation during AFOI in @entity0 with @entity2 @entity7 . METHODS: This study comprised 54 @entity0 , American Society of Anesthesiologists physical status 1, scheduled for @entity2 surgery. The @entity0 were randomly allocated to @entity5 group (n = 18, 0.75  g/kg over 30 seconds), @entity6 group (n = 18, 0.25 mg/kg over 30 seconds), or @entity4 group (n = 18, 0.5 mg/kg over 30 seconds) for conscious sedation. The main determinants affecting the @entity0 's outcome included intubation time, intubation conditions, and @entity0 discomfort, which were determined by scoring system. In addition, postoperative @entity0 dissatisfaction, hemodynamic stability, and @entity3 were measured. RESULTS: Intubation times were significantly different between groups (P < 0.001), where @entity5 had the shortest time (30.28 seconds). Intubation conditions (scores 0-3) were significantly different between groups (P < 0.001).In this context, @entity5 had score 3 (2-3), which was higher compared with 2 (1-3) for @entity6 and 2 (1-2) for @entity4 . @entity0 discomfort score was lowest in the @entity5 group. Hemodynamic stability was maintained within groups, and its changes were not significant (P > 0.05). Postoperative @entity0 's dissatisfaction was observed in 2, 3, and 5 @entity0 in @entity5 , @entity6 , and @entity4 groups, respectively. @entity3 ( @entity1 ) recorded lowest in the @entity5 group. CONCLUSIONS: @entity5 was the best agent for AFOI, because it provided shorter intubation time, better intubation conditions, and least @entity0 's complaint.Iranian registry no.: IRCT 201208061674N4 (www.irct.ir).

title: XXXX , @entity6 , and @entity4 in Awake Nasotracheal Fiberoptic Intubation in Temporomandibular Joint Ankylosis Surgery.

answer: @entity5


abstract: UNASSIGNED: Background: Continuous subcutaneous @entity3 infusion (CSII) is increasing worldwide, mostly because of improved technology. The aim of this study was to evaluate the current status of CSII in Italy. Materials and Methods: Physicians from 272 @entity1 centers received a questionnaire investigating clinical features, pump technology, and management of @entity0 on CSII. Results: Two hundred seventeen centers (79.8%) joined the study and, by the end of April 2013, gave information about 10,152 @entity0 treated with CSII: 98.2% with @entity1 , 81.4% adults, 57% female, and 61% with a conventional pump versus 39% with a sensor-augmented pump. CSII advanced functions were used by 68% of @entity0 , and @entity2 sensors were used 12 days per month on average. Fifty-eight percent of @entity1 centers had more than 20 @entity0 on CSII, but there were differences among centers and among regions. The main indication for CSII was poor @entity2 control. Dropout was mainly due to pump wearability or nonoptimal glycemic control. Twenty-four hour assistance was guaranteed in 81% of centers. A full @entity1 team (physician+nurse+dietician+psychologist) was available in 23% of adult-care @entity1 centers and in 53% of pediatric @entity1 units. Conclusions: CSII keeps increasing in Italy. More work is needed to ensure uniform treatment strategies throughout the country and to improve pump use.

title: Continuous Subcutaneous XXXX Infusion in Italy: Third National Survey.

answer: @entity3


abstract: BACKGROUND: More than 80,000 @entity0 undergo resection of a @entity1 each year, and the only method to determine if the @entity2 is malignant is histologic analysis. We propose that a targeted molecular contrast agent could bind @entity5 , which could be identified using real-time optical imaging at the time of surgery. METHODS: Fifty @entity0 with a biopsy-proven @entity5 were enrolled. Before surgery, @entity0 were systemically administered 0.1 mg/kg of a fluorescent @entity4 receptor alpha (FRa)-targeted molecular contrast agent by intravenous infusion. During surgery, @entity2 were imaged in situ and ex  vivo, after the lung parenchyma was dissected to directly expose the @entity2 to the imaging system. RESULTS: @entity2 ranged from 0.3 to 7.5 cm (mean: 2.6 cm), and 46 of 50 (92%) @entity5 were fluorescent. No false uptake occurred, and in 2 cases, intraoperative imaging revealed @entity2 metastases (3 mm and 6 mm) that were not recognized preoperatively. Four @entity3 were not fluorescent, and immunohistochemistry showed that these @entity3 did not express FRa. @entity2 fluorescence was independent of nodule size, uptake of @entity6 , histology, and @entity2 differentiation. Molecular imaging could identify only 7 of the 50 @entity3 in situ in the @entity0 without bisection. The most important predictor of the success of molecular imaging in locating the @entity2 in situ was the distance of the nodule from the pleural surface. CONCLUSIONS: Intraoperative molecular imaging with a targeted contrast agent can identify @entity5 , and this technology is currently useful in @entity0 with @entity2 , irrespective of size. With further refinements, this tool may prove useful in locating @entity3 that are deeper in the lung parenchyma, in lymph nodes, and at pleural and resection margins.

title: Intraoperative molecular imaging can identify XXXX during pulmonary resection.

answer: @entity5


abstract: UNASSIGNED: Existing brain-based emotion-cognition theories fail to explain arousal's ability to both enhance and impair cognitive processing. In the @entity1 Amplifies Noradrenergic Effects (GANE) model outlined in this paper, we propose that arousal-induced @entity0 (NE) released from the locus coeruleus (LC) biases perception and memory in favor of salient, high priority representations at the expense of lower priority representations. This increase in gain under phasic arousal occurs via synaptic self-regulation of NE based on @entity1 levels. When the LC is phasically active, elevated levels of @entity1 at the site of prioritized representations increase local NE release, creating "NE hot spots." At these local hot spots, @entity1 and NE release are mutually enhancing and amplify activation of prioritized representations. This excitatory effect contrasts with widespread NE suppression of weaker representations via lateral and auto-inhibitory processes. On a broader scale, hot spots increase oscillatory synchronization across neural ensembles transmitting high priority information. Furthermore, key brain structures that detect or pre-determine stimulus priority interact with phasic NE release to preferentially route such information through large-scale functional brain networks. A surge of NE before, during or after encoding enhances synaptic plasticity at sites of high @entity1 activity, triggering local protein synthesis processes that enhance selective memory consolidation. Together, these noradrenergic mechanisms increase perceptual and memory selectivity under arousal. Beyond explaining discrepancies in the emotion-cognition literature, GANE reconciles and extends previous influential theories of LC neuromodulation by highlighting how NE can produce such different outcomes in processing based on priority.

title: XXXX ignites local hot spots of neuronal excitation: How arousal amplifies selectivity in perception and memory.

answer: @entity0


abstract: OBJECTIVE: To determine characteristics of the peritumoral pseudocapsule (PC) between @entity1 subtypes. METHODS: The peritumoral PCs of 160 pT1 @entity1 were examined, including 60 @entity2 ( @entity2 ), 50 papillary @entity2 , 25 chromophobe @entity2 , and 25 @entity3 . Pathologic features (presence or absence of PC, mean thickness, continuity, and invasion by @entity0 ) were analyzed. PC thickness was measured using an ocular micrometer to the nearest 1/10  mm. RESULTS: A complete PC was found in 77% of clear cell @entity0 , 74% of papillary, 28% of chromophobe, and 4% of @entity3 . @entity0 PC was present but incomplete in 18% of clear cell, 18% of papillary, 44% of chromophobe, and 56% of @entity3 . The PC was entirely absent in no clear cell @entity0 , 6% of papillary, 28% of chromophobe, and 40% of @entity3 . Mean PC thickness and presence of invasion beyond the PC differed significantly by @entity0 subtype. @entity5 possessed the thickest PC showing invasion through the capsule in 8% of @entity0 compared to 30% of @entity0 . Complete PC invasion was not seen in chromophobe @entity2 or @entity4 . @entity3 and chromophobe @entity2 characteristically exhibited an incomplete or absent PC. CONCLUSION: The characteristics of peritumoral PC vary predictably with histologic subtype of @entity1 . @entity5 shows the most consistent PC, with a lower rate of invasion beyond it compared to papillary @entity2 . Chromophobe and @entity3 characteristically have an incomplete or absent PC.

title: Characteristics of the Peritumoral Pseudocapsule Vary Predictably With Histologic Subtype of T1 XXXX .

answer: @entity1


abstract: UNASSIGNED: Gonadotrophin  -releasing hormone ( @entity3 ) agonists ( @entity1 ) have been widely used to induce a state of downregulation for in  vitro fertilization, and its direct effects on the pituitary are well known. However, the effects of @entity1 on the expression of anti  -mullerian hormone ( @entity2 ) by follicles in varying stages in  vivo remain to be fully elucidated. In the present study 84  cyclic @entity0 were randomly divided equally into four @entity1 groups and three cyclic @entity0 were used as a control group. The expression levels of @entity2 in follicles of varying stages between days  0 and  7 following @entity1 administration were quantified using immunohistochemistry. The expression of @entity2 in follicles at various stages revealed dynamic changes during the process of downregulation. @entity2 in primary follicles initially increased and then decreased gradually. In small and large preantral follicles and in granulosa cells (GCs) surrounding the oocyte of small antral follicles, the expression of @entity2 began to increase on day  1, was attenuated on day  2, and then increased to a peak. The expression levels of @entity2 in the GCs surrounding the basement membrane, in contrast to the GCs surrounding the oocyte, were significantly lower and did not increase on day  1. In all stages of follicles, the expression of @entity2 declined gradually between the peak level and last day of downregulation. On day  7, the varying follicular stages all expressed lower levels of @entity2 than on day  0. This decrease was more prominent in the higher dose groups, compared with the lower dose groups. In conclusion, @entity1 was observed to induce time  -dependent changes in the expression of @entity2 at varying follicular stages, which occurred in a dose  -dependent manner.

title: Effects of XXXX agonists on the expression of developmental follicular anti  -mullerian hormone in varying follicular stages in cyclic @entity0 in  vivo.

answer: @entity3


abstract: UNASSIGNED: Gonadotrophin  -releasing hormone ( @entity3 ) agonists ( @entity1 ) have been widely used to induce a state of downregulation for in  vitro fertilization, and its direct effects on the pituitary are well known. However, the effects of @entity1 on the expression of anti  -mullerian hormone ( @entity2 ) by follicles in varying stages in  vivo remain to be fully elucidated. In the present study 84  cyclic @entity0 were randomly divided equally into four @entity1 groups and three cyclic @entity0 were used as a control group. The expression levels of @entity2 in follicles of varying stages between days  0 and  7 following @entity1 administration were quantified using immunohistochemistry. The expression of @entity2 in follicles at various stages revealed dynamic changes during the process of downregulation. @entity2 in primary follicles initially increased and then decreased gradually. In small and large preantral follicles and in granulosa cells (GCs) surrounding the oocyte of small antral follicles, the expression of @entity2 began to increase on day  1, was attenuated on day  2, and then increased to a peak. The expression levels of @entity2 in the GCs surrounding the basement membrane, in contrast to the GCs surrounding the oocyte, were significantly lower and did not increase on day  1. In all stages of follicles, the expression of @entity2 declined gradually between the peak level and last day of downregulation. On day  7, the varying follicular stages all expressed lower levels of @entity2 than on day  0. This decrease was more prominent in the higher dose groups, compared with the lower dose groups. In conclusion, @entity1 was observed to induce time  -dependent changes in the expression of @entity2 at varying follicular stages, which occurred in a dose  -dependent manner.

title: Effects of @entity3 agonists on the expression of developmental follicular anti  -mullerian hormone in varying follicular stages in cyclic XXXX in  vivo.

answer: @entity0


abstract: BACKGROUND: Treatment of @entity3 associated with @entity2 such as @entity1 is still inadequate and requires development of new drugs. OBJECTIVE: The objective was to evaluate the memory enhancing effect of Celastrus paniculatus seed oil. MATERIALS AND METHODS: C. paniculatus seed oil was mixed with equal amount of pure ghee and administered orally to @entity0 in the dose of 200 mg/kg/day. @entity4 was used as a standard nootropic. Elevated plus maze and passive avoidance tests were used as a models to test spatial and fear memory respectively. @entity5 (3 mg/kg, i.p.), was used as an amnestic agent. RESULTS: @entity0 receiving C. paniculatus showed significant memory enhancement as compared to @entity5 group. The effect of C. paniculatus and combination of C. paniculatus with @entity4 was comparable to that with @entity4 alone. CONCLUSION: The present study demonstrates that C. paniculatus seed oil has memory enhancing effect and hence can be developed as a potential drug in the treatment of @entity2 .

title: Effect of Jyoti   mat   seed oil on spatial and fear memory using XXXX induced amnesia in @entity0 .

answer: @entity5


abstract: BACKGROUND: Treatment of @entity3 associated with @entity2 such as @entity1 is still inadequate and requires development of new drugs. OBJECTIVE: The objective was to evaluate the memory enhancing effect of Celastrus paniculatus seed oil. MATERIALS AND METHODS: C. paniculatus seed oil was mixed with equal amount of pure ghee and administered orally to @entity0 in the dose of 200 mg/kg/day. @entity4 was used as a standard nootropic. Elevated plus maze and passive avoidance tests were used as a models to test spatial and fear memory respectively. @entity5 (3 mg/kg, i.p.), was used as an amnestic agent. RESULTS: @entity0 receiving C. paniculatus showed significant memory enhancement as compared to @entity5 group. The effect of C. paniculatus and combination of C. paniculatus with @entity4 was comparable to that with @entity4 alone. CONCLUSION: The present study demonstrates that C. paniculatus seed oil has memory enhancing effect and hence can be developed as a potential drug in the treatment of @entity2 .

title: Effect of Jyoti   mat   seed oil on spatial and fear memory using @entity5 induced amnesia in XXXX .

answer: @entity0


abstract: AIM: Statistical Parametric Mapping (SPM) has been applied for single--subject evaluation of @entity5 uptake in @entity2 ( @entity2 ). In a single--subject framework, the @entity0 is compared to a dataset of @entity5 PET images from @entity4 ( @entity4 ) evaluating brain @entity3 . No studies exist that assess the effects on SPM analysis of @entity4 @entity5 PET datasets acquired from different subjects and using different PET scanners including the same or different PET scanners than those used for @entity0 . This work aims to elucidate this issue from a methodological perspective. METHODS: We considered six different @entity5 PET datasets, from different @entity4 populations, acquired by different PET scanners. We applied SPM5 procedures for single--subject comparison with each of the six @entity4 datasets in 10 probable @entity2 @entity0 showing the typical @entity5 pattern. We also implemented the same comparison in 3 probable @entity2 @entity0 and in 7 @entity0 with a clinical diagnosis of @entity1 ( @entity1 ), showing subtle changes on visual inspection of @entity5 distribution. RESULTS: Considering the 10 @entity0 with the typical @entity5 pattern, the results were comparable for all the SPM maps. In the 3 probable @entity2 @entity0 with subtle changes in @entity5 distribution, no significant @entity2 pattern emerged when a small number (<20) of @entity4 was used, whereas a significant @entity2 pattern appeared when a large (>50) @entity4 image set was used. In the 7 considered @entity1 @entity0 the use of a large (>50) @entity4 image set allowed to assess significant hypo metabolic patterns related to a probable neurodegenerative pathology. CONCLUSION: The use of large @entity4 datasets of PET scans (>50) is recommended for single--subject SPM analysis. On condition that appropriate pre--processing steps are provided, large @entity4 datasets can include @entity4 images acquired with different PET systems, not including images from the same scanner of that used for @entity0 .

title: The impact of different 18FDG PET Healthy Subject scans for comparison with single XXXX in SPM analysis.

answer: @entity0


abstract: Vascular endothelium activated by endotoxin (lipopolysaccharide [LPS]) and cytokines plays an important role in organ @entity2 and blood leukocyte recruitment observed during @entity4 . Endothelial cells can be activated by LPS directly, after its interaction with LPS-binding protein and soluble @entity8 in plasma. LPS-LPS-binding protein complexes in blood also interact with monocytes and neutrophils bearing @entity7 (GPI) anchored membrane @entity8 ( @entity9 ), promoting the release of cytokines such as @entity1 @entity3 factor and @entity6 ). These molecules, in turn, have the capacity to activate endothelial cells providing an indirect pathway for LPS-dependent endothelial cell activation. In this work, we address the relative importance of the direct and the indirect pathway of in vitro LPS-induced @entity0 umbilical vein endothelial cell (HUVEC) activation. Substituting whole blood for plasma resulted in a 1,000-fold enhancement of HUVEC sensitivity to LPS. Both blood- and plasma-dependent enhanced activation of HUVEC were blocked with an anti- @entity8 monoclonal antibody. Blood from @entity0 with @entity10 , whose cells lack @entity9 and other GPI anchored proteins, was unable to enhance LPS activation of HUVEC above the level observed with plasma alone. @entity5 , an inhibitor of monocyte release of cytokines, decreased the blood-dependent enhancement of HUVEC activation by LPS. Blood adapted to small doses of LPS was also less efficient than nonadapted blood in producing this enhancement. Addition of purified mononuclear cells to HUVEC or the transfer of plasma from whole blood incubated with LPS to HUVEC, duplicated the enhancement effect observed when whole blood was incubated with HUVEC. Taken together, these data suggest that the indirect pathway of LPS activation of endothelial cell is mediated by monocytes and @entity9 through the secretion of a soluble mediator(s). The indirect pathway is far more efficient than the direct, plasma-dependent pathway.

title: A critical role for monocytes and XXXX in endotoxin-induced endothelial cell activation.

answer: @entity8


abstract: Background  -Glutamyl transpeptidase 1 ( @entity4 ) is an N-glycosylated membrane protein that catabolizes extracellular glutathione and other   -glutamyl-containing substrates. In a variety of disease states, including @entity1 formation, the enzyme is shed from the surface of the cell and can be detected in serum. The structures of the N-glycans on @entity0 @entity4 ( @entity4 ) have been shown to be tissue-specific. Tumor-specific changes in the glycans have also been observed, suggesting that the N-glycans on @entity4 would be an important biomarker for detecting @entity1 and monitoring their progression during treatment. However, the large quantities of purified protein required to fully characterize the carbohydrate content poses a significant challenge for biomarker development. Herein, we investigated a new antibody-lectin sandwich array (ALSA) platform to determine whether this microanalytical technique could be applied to the characterization of N-glycan content of @entity4 in complex biological samples.ResultsOur data show that @entity4 can be isolated from detergent extracted membrane proteins by binding to the ALSA platform. Probing @entity4 with lectins enables characterization of the N-glycans. We probed @entity4 from normal @entity0 liver tissue, normal @entity0 kidney tissue, and @entity4 expressed in the @entity2 @entity3 . The lectin binding patterns obtained with the ALSA platform are consistent with the @entity4 N-glycan composition obtained from previous large-scale @entity4 N-glycan characterizations from these sources. We also validate the implementation of the @entity5 lectin, microvirin, in this platform and provide refined evidence for its efficacy in specifically recognizing high-mannose-type N-glycans, a class of carbohydrate modification that is distinctive of @entity4 expressed by many @entity1 .ConclusionUsing this microanalytical approach, we provide proof-of-concept for the implementation of ALSA in conducting high-throughput studies aimed at investigating disease-related changes in the glycosylation patterns on @entity4 with the goal of enhancing clinical diagnoses and targeted treatment regimens.

title: Detection of distinct glycosylation patterns on XXXX   -glutamyl transpeptidase 1 using antibody-lectin sandwich array (ALSA) technology.

answer: @entity0


abstract: BACKGROUND: Massively parallel gene expression profiling has provided a more objective, molecular-level characterization of @entity0 subtypes. Several bioinformatics tools are available to infer @entity1 subtype from a gene expression profile including the well-studied PAM50. The specific algorithmic methods used in these tools require access to a broad @entity1 dataset. The choice of subtype for an individual is determined relative to all other @entity1 across the panel, making subtypes heavily dependent on the composition of the dataset. Our aim was to develop a bioinformatics approach assigning absolute @entity0 subtypes, independent of dataset composition. METHODS: Using a dataset of 4924 @entity0 @entity1 , we defined a new bioinformatics approach: @entity2 ( @entity2 ) that assigns subtype from a gene expression profile for an individual sample without the need for a large, diverse, and normalized dataset. We evaluated the agreement of @entity2 with PAM50 and compared subtype assignment and prognostic value of the subtypes. We assessed @entity2 ' robustness using a benchmark set of tests including subtype reproducibility between technologies, gene removal, and normal gene expression contamination, and compared it with PAM50. All statistical tests, except where noted, were two-sided. RESULTS: @entity2 vastly agreed with PAM50, with 76% and 77% agreement for cross validation and the test set, respectively, and the prognostic capacity of the intrinsic subtypes was preserved. @entity2 is fully stable, and its absolute nature enables its use on a wide range of datasets and technologies, including RNA-seq. CONCLUSIONS: The instability of a @entity0 subtyping scheme like PAM50 could have important consequences in clinical management of @entity1 . @entity2 is a fully stable and robust subtyping scheme that recapitulates PAM50.

title: Absolute assignment of XXXX intrinsic molecular subtype.

answer: @entity0


abstract: @entity3 has recently been shown to immortalize @entity0 T cells. It was unknown, however, whether @entity3 transformation affects T-cell receptor ( @entity8 ) expression and signal transduction. In the present study, we have transformed @entity2 + @entity0 T-cell clones specific for @entity0 @entity6 . The transformed T cells were grown in @entity5 and divided in the absence of antigen and antigen-presenting cells. They retained the membrane phenotype of activated T cells and secreted the cytokines interferon gamma and lymphotoxin, but @entity7 was not detected. Further, the transformed T cells continued to express the original @entity8 as demonstrated by @entity8 variable-region-V beta-specific monoclonal antibodies and @entity8 sequencing. Antigen-specific recognition and signal transduction by the @entity8 were demonstrated by @entity6 -induced HLA-DR-restricted secretion of interferon gamma and lymphotoxin and by @entity6 -specific proliferation. Antigen specificity and reactivity have been maintained for > 1 year after transformation. Transformation with @entity3 now allows the production of virtually unlimited numbers of (auto)antigen-specific T cells expressing functional @entity8 and a stable membrane phenotype. This technology will facilitate studies of the pathogenesis of putative @entity4 , such as @entity1 , and may be of help in @entity8 -targeted immunotherapy.

title: Transformation of @entity0 T-cell clones by Herpesvirus saimiri: intact antigen recognition by autonomously growing XXXX -specific T cells.

answer: @entity6


abstract: @entity3 has recently been shown to immortalize @entity0 T cells. It was unknown, however, whether @entity3 transformation affects T-cell receptor ( @entity8 ) expression and signal transduction. In the present study, we have transformed @entity2 + @entity0 T-cell clones specific for @entity0 @entity6 . The transformed T cells were grown in @entity5 and divided in the absence of antigen and antigen-presenting cells. They retained the membrane phenotype of activated T cells and secreted the cytokines interferon gamma and lymphotoxin, but @entity7 was not detected. Further, the transformed T cells continued to express the original @entity8 as demonstrated by @entity8 variable-region-V beta-specific monoclonal antibodies and @entity8 sequencing. Antigen-specific recognition and signal transduction by the @entity8 were demonstrated by @entity6 -induced HLA-DR-restricted secretion of interferon gamma and lymphotoxin and by @entity6 -specific proliferation. Antigen specificity and reactivity have been maintained for > 1 year after transformation. Transformation with @entity3 now allows the production of virtually unlimited numbers of (auto)antigen-specific T cells expressing functional @entity8 and a stable membrane phenotype. This technology will facilitate studies of the pathogenesis of putative @entity4 , such as @entity1 , and may be of help in @entity8 -targeted immunotherapy.

title: Transformation of XXXX T-cell clones by Herpesvirus saimiri: intact antigen recognition by autonomously growing @entity6 -specific T cells.

answer: @entity0


abstract: Transabdominal sacrocolpopexy has been shown, in multiple long-term studies of its success and durability, to be the definitive treatment option for post-hysterectomy @entity1 . It is, however, associated with greater morbidity than vaginal repair. We describe a minimally invasive technique for @entity1 repair and present our experience with a minimum of one-year follow-up. The surgical technique involves five laparoscopic ports-three for the da Vinci robot and two for the assistant. After appropriate dissection a @entity2 mesh is attached to the sacral promontory and to the vaginal apex by use of Gore-Tex sutures. The mesh material is then covered by the peritoneum. @entity0 analysis focused on complications, urinary continence, @entity0 satisfaction, and morbidity, with a minimum of 12  months follow-up. Forty-two @entity0 with post-hysterectomy @entity1 underwent robot-assisted laparoscopic sacrocolpopexy at our institute and 35 have a minimum of 12  months follow-up, with a mean follow-up of 36  months (range 12-48) in the group. Mean age was 67 (47-83) years and mean operating time was 3.1 (2.15-4.75)  h for the entire cohort. All but one @entity0 were discharged home on postoperative day one; one @entity0 left on postoperative day two. One developed recurrent grade three rectocele, one had recurrent vault prolapse, and two suffered from vaginal extrusion of mesh. All @entity0 were satisfied with their outcome. The robot-assisted laparoscopic sacrocolpopexy is a minimally invasive technique for @entity1 repair, combining the advantages of open sacrocolpopexy with the reduced morbidity of laparoscopy. We observed reduced hospital stay, low occurrence of complications, and high @entity0 satisfaction, with a minimum of 1-year follow-up. Most importantly, the long-term results of the robotic repair are similar to those of open repair, but with significantly less morbidity.

title: Assessment of the durability of robot-assisted laparoscopic sacrocolpopexy for treatment of XXXX .

answer: @entity1


abstract: BACKGROUND: There is an extensive literature describing a central @entity4 deficit in @entity5 and fire setters. In the present study, we investigated biochemical concomitants of @entity0 and @entity1 , and the physiological consequences of reduced central serotonin turnover. METHODS: Forty-three impulsive and 15 nonimpulsive alcoholic offenders and 21 healthy volunteers were studied in the forensic psychiatry ward of a university psychiatric department. The subjects underwent lumbar punctures and oral @entity3 and @entity9 challenges, and their diurnal activity rhythm was measured with physical activity monitors. Discriminant function analyses were used to investigate psychophysiological and biochemical concomitants of aggressive and @entity1 . RESULTS: Alcoholic, impulsive offenders with @entity8 had low mean cerebrospinal fluid (CSF) @entity6 ( @entity7 ) and corticotropin levels and high mean CSF @entity2 concentrations. Compared with healthy volunteers, they showed increased physical activity during the daytime. Alcoholic, impulsive offenders with @entity0 had a low mean CSF @entity7 concentration and blood @entity3 nadir after an oral @entity3 challenge, and desynchronized diurnal activity rhythm. Healthy volunteers had mean CSF @entity7 concentrations that were intermediate between those of alcoholic, impulsive and nonimpulsive offenders. Alcoholic, nonimpulsive offenders had a significantly higher mean CSF @entity7 concentration than all the other groups, including healthy volunteers. CONCLUSIONS: In the present sample, a low CSF @entity7 concentration was primarily associated with @entity0 and high CSF @entity2 concentration, with @entity1 or interpersonal violence.

title: CSF biochemistries, XXXX metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers.

answer: @entity3


abstract: @entity3 are signals associated with both food's availability and pleasure. Previous research from this laboratory has shown that food aromas under fasting conditions evoke robust activation of medial prefrontal brain regions thought to reflect reward value (Bragulat, et al. 2010). In the current study, eighteen @entity0 (eleven normal-weight and seven @entity1 ) underwent a two-day imaging study (one after being fed, one while fasting). All were imaged on a 3T Siemens Trio-Tim scanner while sniffing two food (F; pasta and beef) odors, one non-food (NF; Douglas fir) odor, and an odorless control (CO). Prior to imaging, @entity0 rated hunger and perceived odor qualities, and completed the Dutch Eating Behavior Questionnaire (DEBQ) to assess "Externality" (the extent to which eating is driven by external food cues). Across all @entity0 , both food and non-food odors (compared to CO) elicited large blood oxygenation level dependent (BOLD) responses in olfactory and reward-related areas, including the medial prefrontal and anterior cingulate cortex, bilateral orbitofrontal cortex, and bilateral piriform cortex, amygdala, and hippocampus. However, food odors produced greater activation of medial prefrontal cortex, @entity2 than non-food odors. Moreover, there was a significant correlation between the [F > CO] BOLD response in ventromedial prefrontal cortex and "Externality" sub-scale scores of the DEBQ, but only under the fed condition; no such correlation was present with the [NF > CO] response. This suggests that in those with high Externality, ventromedial prefrontal cortex may inappropriately valuate external food cues in the absence of internal hunger.

title: Correlation between XXXX and Cue-driven Eating: An fMRI Study.

answer: @entity2


abstract: PURPOSE: This study evaluates chemoembolization (CE) of the liver with minimal vasoconstriction followed by selective intraarterial delivery of an emulsion of @entity7 , @entity5 , and ethiodized oil and temporary occlusion of hepatic artery with gelatin sponge powder in @entity0 with @entity4 . @entity0 AND METHODS: Since 1988, 30 @entity0 with nonresectable @entity4 underwent CE with the above protocol. Intraarterial @entity6 (0.5-1 microgram diluted in 10 mL of saline) was rapidly injected directly into the proper hepatic artery or selectively into the right or left hepatic arteries and was followed by 40-60 mg of @entity5 dissolved in 10 mL of @entity7 and emulsified in 20 mL of ethiodized oil. The chemoembolic mixture was injected at the rate of arterial flow. Liver function and clotting parameters were monitored three times a day until there was a downward trend toward preembolic levels. Computed tomography (CT) was performed immediately after embolization and at 1-3-month intervals. Embolization was repeated when CT demonstrated recurrent or progressive disease. RESULTS: Disease recurred or progressed in 11 @entity0 at 2-17 months after embolization. CE was repeated in four @entity0 ; one individual underwent three embolizations. Re-embolization was performed up to 14 months after initial embolization (median, 10 months). Five @entity0 (16.7%) died within 1 month of embolization. Ten @entity0 died at 3-33 months after CE. Two of these @entity0 died of @entity3 at 6 and 14 months, without evidence of recurrent @entity1 . Fifteen @entity0 remain alive 5-28 months after CE. Kaplan-Meier estimation of probability of survival curves demonstrates a median survival of 14 months. Sixty-one percent of @entity0 were alive at 1 year and 36% at 2 years after the procedure. CONCLUSION: CE with use of the above technique is effective for palliating inoperable @entity4 . It causes a significant prolongation of survival over the expected 18-24 weeks in untreated @entity0 ; this may occur because high doses of chemotherapeutic agents are delivered and come in contact with the @entity1 for a longer period, followed by @entity2 brought about by temporary arterial occlusion.

title: @entity4 : XXXX followed by a @entity5 -ethiodized oil emulsion and gelatin sponge powder.

answer: @entity6


abstract: PURPOSE: This study evaluates chemoembolization (CE) of the liver with minimal vasoconstriction followed by selective intraarterial delivery of an emulsion of @entity7 , @entity5 , and ethiodized oil and temporary occlusion of hepatic artery with gelatin sponge powder in @entity0 with @entity4 . @entity0 AND METHODS: Since 1988, 30 @entity0 with nonresectable @entity4 underwent CE with the above protocol. Intraarterial @entity6 (0.5-1 microgram diluted in 10 mL of saline) was rapidly injected directly into the proper hepatic artery or selectively into the right or left hepatic arteries and was followed by 40-60 mg of @entity5 dissolved in 10 mL of @entity7 and emulsified in 20 mL of ethiodized oil. The chemoembolic mixture was injected at the rate of arterial flow. Liver function and clotting parameters were monitored three times a day until there was a downward trend toward preembolic levels. Computed tomography (CT) was performed immediately after embolization and at 1-3-month intervals. Embolization was repeated when CT demonstrated recurrent or progressive disease. RESULTS: Disease recurred or progressed in 11 @entity0 at 2-17 months after embolization. CE was repeated in four @entity0 ; one individual underwent three embolizations. Re-embolization was performed up to 14 months after initial embolization (median, 10 months). Five @entity0 (16.7%) died within 1 month of embolization. Ten @entity0 died at 3-33 months after CE. Two of these @entity0 died of @entity3 at 6 and 14 months, without evidence of recurrent @entity1 . Fifteen @entity0 remain alive 5-28 months after CE. Kaplan-Meier estimation of probability of survival curves demonstrates a median survival of 14 months. Sixty-one percent of @entity0 were alive at 1 year and 36% at 2 years after the procedure. CONCLUSION: CE with use of the above technique is effective for palliating inoperable @entity4 . It causes a significant prolongation of survival over the expected 18-24 weeks in untreated @entity0 ; this may occur because high doses of chemotherapeutic agents are delivered and come in contact with the @entity1 for a longer period, followed by @entity2 brought about by temporary arterial occlusion.

title: @entity4 : @entity6 followed by a XXXX -ethiodized oil emulsion and gelatin sponge powder.

answer: @entity5


abstract: PURPOSE: This study evaluates chemoembolization (CE) of the liver with minimal vasoconstriction followed by selective intraarterial delivery of an emulsion of @entity7 , @entity5 , and ethiodized oil and temporary occlusion of hepatic artery with gelatin sponge powder in @entity0 with @entity4 . @entity0 AND METHODS: Since 1988, 30 @entity0 with nonresectable @entity4 underwent CE with the above protocol. Intraarterial @entity6 (0.5-1 microgram diluted in 10 mL of saline) was rapidly injected directly into the proper hepatic artery or selectively into the right or left hepatic arteries and was followed by 40-60 mg of @entity5 dissolved in 10 mL of @entity7 and emulsified in 20 mL of ethiodized oil. The chemoembolic mixture was injected at the rate of arterial flow. Liver function and clotting parameters were monitored three times a day until there was a downward trend toward preembolic levels. Computed tomography (CT) was performed immediately after embolization and at 1-3-month intervals. Embolization was repeated when CT demonstrated recurrent or progressive disease. RESULTS: Disease recurred or progressed in 11 @entity0 at 2-17 months after embolization. CE was repeated in four @entity0 ; one individual underwent three embolizations. Re-embolization was performed up to 14 months after initial embolization (median, 10 months). Five @entity0 (16.7%) died within 1 month of embolization. Ten @entity0 died at 3-33 months after CE. Two of these @entity0 died of @entity3 at 6 and 14 months, without evidence of recurrent @entity1 . Fifteen @entity0 remain alive 5-28 months after CE. Kaplan-Meier estimation of probability of survival curves demonstrates a median survival of 14 months. Sixty-one percent of @entity0 were alive at 1 year and 36% at 2 years after the procedure. CONCLUSION: CE with use of the above technique is effective for palliating inoperable @entity4 . It causes a significant prolongation of survival over the expected 18-24 weeks in untreated @entity0 ; this may occur because high doses of chemotherapeutic agents are delivered and come in contact with the @entity1 for a longer period, followed by @entity2 brought about by temporary arterial occlusion.

title: XXXX : @entity6 followed by a @entity5 -ethiodized oil emulsion and gelatin sponge powder.

answer: @entity4


abstract: BACKGROUND: We previously established three logistic regression models for discriminating @entity2 status based on morphological and hemodynamic analysis of 119 @entity1 . In this study, we tested if these models would remain stable with increasing sample size, and investigated sample sizes required for various confidence levels (CIs). METHODS: We augmented our previous dataset of 119 @entity1 into a new dataset of 204 samples by collecting an additional 85 consecutive @entity1 , on which we performed flow simulation and calculated morphological and hemodynamic parameters, as done previously. We performed univariate significance tests on these parameters, and multivariate logistic regression on significant parameters. The new regression models were compared against the original models. Receiver operating characteristics analysis was applied to compare the performance of regression models. Furthermore, we performed regression analysis based on bootstrapping resampling statistical simulations to explore how many @entity1 cases were required to generate stable models. RESULTS: Univariate tests of the 204 @entity1 generated an identical list of significant morphological and hemodynamic parameters as previously (from the analysis of 119 cases). Furthermore, multivariate regression analysis produced three parsimonious predictive models that were almost identical to the previous ones, with model coefficients that had narrower CIs than the original ones. Bootstrapping showed that 10%, 5%, 2%, and 1% convergence levels of CI required 120, 200, 500, and 900 @entity1 , respectively. CONCLUSIONS: Our original hemodynamic-morphological @entity0 models are stable and improve with increasing sample size. Results from resampling statistical simulations provide guidance for designing future large multi-population studies.

title: Hemodynamic-morphological discriminant models for XXXX remain stable with increasing sample size.

answer: @entity2


abstract: A @entity0 genomic DNA library was surveyed with respect to the template activity for RNA-primed DNA synthesis by @entity0 thymus DNA polymerase alpha-primase complex. About 7% of the single-stranded DNA clones contained distinct initiation sites consisting of @entity2 clusters of @entity2 -rich sequences. The initiation sites were located at or near the 3'-end of the @entity2 clusters. One of these sequences, containing a 10-mer @entity2 cluster with major initiation sites, was analyzed in detail. By the successive substitutions of @entity1 in the cluster with oligodeoxydenylate @entity4 in the 5' to 3' direction, the minimum length of the initiation sequence was estimated to be as long as the 7-mer. In contrast, when one or three @entity1 at the 3'-end of the cluster were replaced with (dA)n, the priming activity was largely lost, indicating that these @entity2 residues were indispensable for priming. Furthermore, base substitutions of upstream or downstream sequences outside the @entity2 cluster also decreased the total priming frequencies. Interestingly, the base substitutions inside or outside of the @entity2 cluster sometimes caused a shift in the major priming sites. These results indicate that the minimum priming unit of the CTPPS1 template for RNA-primed DNA synthesis consists of a @entity2 cluster (6-mer) with one @entity3 at its 3'-border and that both the 3'-downstream 6-bases and the 5'-upstream 17-bases modulate the priming by enhancing the priming frequency and/or slightly shifting the sites of initiation of primer synthesis. It was also revealed that the lengths of the product RNA primers became shorter as the length of @entity2 cluster was shortened by substitution with (dA)n. The gel retardation assay further showed that the complex formation between DNA polymerase alpha-primase and the DNA templates was strongly in competition with @entity5 , @entity6 , and poly(dT) but not with poly(dA). Furthermore, template activities as well as the @entity2 contents of a series of base-substituted DNA correlated well with their affinities to the enzyme, as measured by both gel retardation assay and their Km values for the priming reaction. Apparently, DNA polymerase alpha-primase primarily recognizes the minimum priming unit consisting of a @entity2 cluster with a @entity3 at the 3'-boundary of @entity3 , but the initiation of primer RNA synthesis can be modified by @entity2 residues outside of the minimum priming unit.

title: RNA priming coupled with DNA synthesis on natural template by XXXX thymus DNA polymerase alpha-primase.

answer: @entity0


abstract: BACKGROUND: Various stent models have been developed for the treatment of inoperable stenoses of the central airways caused by external compression. Increasing use is made of the silicone stents designed by Dumon. We tested their technical feasibility, tolerance, and long-term efficacy in relieving respiratory symptoms in @entity0 referred for endoscopic palliation of @entity1 . METHODS: All procedures were performed under general anesthesia with the use of the rigid bronchoscope. We inserted 38 stents in 31 @entity0 (median age, 67 years; 25 @entity0 and 6 @entity0 ) whose airways showed residual obstruction of > 50 percent of the lumen after laser resection of @entity1 and/or mechanical dilatation of extrinsic compressions. RESULTS: Stent placement and removal--where necessary--were easy in all @entity0 , but five stents inserted in three @entity0 with short (< or = 2.5 cm) and conical stenoses migrated, necessitating emergency removal. In 27 of the remaining 28 @entity0 , stent tolerance was excellent; 1 proximal tracheal stent (< 1 cm below the vocal cords) had to be removed because of @entity6 and @entity2 . One lethal hemoptysis occurred within hours after a repeated laser therapy and removal of an indwelling stent. No other serious complications occurred. Immediate and lasting relief of @entity4 and improvement in performance status (Karnofsky scale, activity index) was achieved in 90 percent (28/31) of @entity0 (p < 0.01). The influence of adjuvant radiotherapy on @entity1 recurrence and survival was analyzed in a subgroup of ten @entity0 with @entity5 with comparable performance status. Five did not undergo adjuvant radiotherapy (group A) and five did (group B). In group A, four of five stents were occluded by @entity1 recurrence above or below the stent after a median follow-up of 2 months; in group B, zero of five were occluded (p < 0.05) after 4 months. Median survival was 4 months in group A and 6 months in group B; the difference did not reach significance. CONCLUSIONS: The @entity3 stents designed by Dumon are easily inserted and removed; they are also well tolerated and very efficacious in relieving respiratory symptoms caused by extrinsic airway compression. Short and conical stenoses present limitations for their use due to increased risk of migration. Combined treatment with laser resection, stent insertion, and subsequent radiotherapy is necessary to prevent @entity1 recurrence and may improve survival.

title: XXXX stents in the management of inoperable tracheobronchial stenoses. Indications and limitations.

answer: @entity3


abstract: OBJECTIVE: To determine the efficacy of treating @entity0 with a recent onset, biopsy-proven keratoacanthoma with short-contact topical 5% @entity1 cream twice daily until resolution. DESIGN: Chart review of 10 @entity0 who applied 5% @entity1 for the treatment of biopsy-proven keratoacanthoma. SETTING: Outpatient clinic of a board-certified dermatologist. @entity0 : The study population was 90-percent @entity0 (9/10), 10-percent @entity0 (1/10) and ranged in ages from 52 to 92 years old with a mean age of 74.4. MEASUREMENTS: @entity0 were followed for weekly visits for the duration of their treatment and at varying, less-frequent intervals after resolution of the lesion clinically. Photographs were taken at each visit. RESULTS: The authors performed a retrospective analysis of 10 @entity0 with biopsy-confirmed @entity2 treated with topical @entity1 . One @entity0 elected to have Mohs surgery after one week of topical @entity1 due to personal concern and cosmetic appearance and did not complain of any side effects due to the drug. Of the nine @entity0 that remained on topical @entity1 , all @entity0 had complete resolution of the lesion within six weeks. The range in the number of weeks to resolution was four to six weeks. Two @entity0 required a one- to two-week drug holiday secondary to erythema, which resolved without any further complication or @entity0 discomfort. All nine @entity0 who continued therapy reported satisfaction with the results and showed excellent compliance with treatment. CONCLUSION: Short-contact topical 5% @entity1 appears to provide excellent cosmetic results and is well-tolerated by @entity0 . This should be an initial consideration for the treatment of @entity2 and does not preclude future surgical intervention if deemed necessary.

title: Clinical efficacy of short contact topical @entity1 in the treatment of XXXX : a retrospective analysis.

answer: @entity2


abstract: OBJECTIVE: To determine the efficacy of treating @entity0 with a recent onset, biopsy-proven keratoacanthoma with short-contact topical 5% @entity1 cream twice daily until resolution. DESIGN: Chart review of 10 @entity0 who applied 5% @entity1 for the treatment of biopsy-proven keratoacanthoma. SETTING: Outpatient clinic of a board-certified dermatologist. @entity0 : The study population was 90-percent @entity0 (9/10), 10-percent @entity0 (1/10) and ranged in ages from 52 to 92 years old with a mean age of 74.4. MEASUREMENTS: @entity0 were followed for weekly visits for the duration of their treatment and at varying, less-frequent intervals after resolution of the lesion clinically. Photographs were taken at each visit. RESULTS: The authors performed a retrospective analysis of 10 @entity0 with biopsy-confirmed @entity2 treated with topical @entity1 . One @entity0 elected to have Mohs surgery after one week of topical @entity1 due to personal concern and cosmetic appearance and did not complain of any side effects due to the drug. Of the nine @entity0 that remained on topical @entity1 , all @entity0 had complete resolution of the lesion within six weeks. The range in the number of weeks to resolution was four to six weeks. Two @entity0 required a one- to two-week drug holiday secondary to erythema, which resolved without any further complication or @entity0 discomfort. All nine @entity0 who continued therapy reported satisfaction with the results and showed excellent compliance with treatment. CONCLUSION: Short-contact topical 5% @entity1 appears to provide excellent cosmetic results and is well-tolerated by @entity0 . This should be an initial consideration for the treatment of @entity2 and does not preclude future surgical intervention if deemed necessary.

title: Clinical efficacy of short contact topical XXXX in the treatment of @entity2 : a retrospective analysis.

answer: @entity1


abstract: BACKGROUND: Hematopoietic colony-stimulating factors are a diverse group of cytokines now commercially available through recombinant technology. The colony-stimulating factors have proven utility in a wide spectrum of cytopenic states, and their use is now common-place. Unlike many cytokines, the colony-stimulating factors are usually well tolerated. We present a dramatic case of @entity5 arising during granulocyte colony-stimulating factor therapy. Additionally, the relevant literature regarding cutaneous complications of colony-stimulating factor therapy is summarized. OBSERVATIONS: Including our case, two reported @entity0 developed @entity5 while under colony-stimulating factor therapy. @entity6 presented in an additional three @entity0 , and @entity4 was precipitated in three others. The @entity1 consistently developed after 1 to 2 weeks of colony-stimulating factor therapy and were apparently unrelated to the underlying @entity2 . Although most reactions developed de novo, three were superimposed on a preexisting inflammatory process. CONCLUSIONS: Serious cutaneous adverse effects of colony-stimulating factors are distinctly rare but include @entity3 and @entity4 . Upregulation of neutrophilic function and secondary release of cytokines may induce these complications. Early recognition and cessation of colony-stimulating factor therapy will limit the morbidity of these adverse events.

title: Leukocyte colony-stimulating factors. A review of associated XXXX and vasculitides.

answer: @entity3


abstract: Low/medium- @entity3 -risk populations undergoing percutaneous coronary intervention (PCI) show significantly less @entity3 with bivalirudin ( @entity6 ) than with unfractionated heparin (UFH), but this has not been established for high-risk @entity0 . We performed a randomized double-blind prospective trial comparing efficacy and safety of @entity6 versus UFH combined with dual antiplatelet therapy during PCI among 100 high-risk @entity0 with non-ST elevation @entity4 (NSTEMI) or @entity5 . The baseline characteristics were similar in both treatment arms. A radial approach was used in 84% of @entity0 with a higher rate in the @entity6 group (90 vs. 78%, p   <   0.05). Study end points were: major and @entity3 , port-of-entry complications, major adverse @entity1 (MACE) in-hospital, and at long-term follow-up. There was one case of major @entity2 in the @entity6 group and 7% @entity3 complications in both categories. Rate of periprocedural @entity4 (PPMI) in the @entity6 group was twice that in the UFH group (20 vs. 10%, p   <   0.16). In-hospital MACE rate was higher in @entity6 @entity0 as well (12 vs. 2%, p   =   0.1). By univariate analysis, the femoral approach was the predictor of PPMI and in-hospital MACE. In a multivariate model, the independent predictor of PPMI was previous MI (odds ratio, 7.7; p   <   0.0158). PPMI was 49.7 times more likely with the femoral approach plus @entity6 than the nonfemoral approach plus UFH (p   <   0.0021). At 41.5        14 months' follow-up, end points did not significantly differ between the groups. In @entity0 at high risk for @entity3 undergoing PCI, @entity6 was not superior to UFH for @entity3 complications, and early and late clinical outcomes.

title: Bivalirudin versus Unfractionated Heparin during Percutaneous Coronary Intervention in XXXX at High Risk for Bleeding.

answer: @entity0


abstract: BACKGROUND: In the context of @entity2 , progressive illness resulting in acute organ dysfunction is thought to be secondary to inflammatory response. Our aims were to determine risk factors for progressive @entity2 in a low-risk hospitalised cohort, including the impact of prior stain therapy. METHODS: We performed a prospective observational cohort study on two adult acute medical wards of a single tertiary academic hospital. We screened drug prescription charts of all adult acute medical admissions for inclusion criteria of inpatient administration of antibiotics for more than 24 hours for a microbiologically confirmed or clinically suspected @entity2 . @entity0 were followed until admission to a high dependency unit (HDU) or intensive care unit (ICU), discharge from hospital, or to a maximum of 10 days. Outcomes were evolution of @entity3 ( @entity3 ) criteria, white cell count and @entity4 measurements, and adverse clinical outcomes. We constructed multivariable models accounting for repeated within- @entity0 measurements to determine associations between a priori selected predictors (days since admission, age, gender, Charlson score, prior statin exposure) and selected outcomes. RESULTS: We enrolled 209 @entity0 ; 27.8% were statin users and the commonest @entity2 was @entity1 (51.0%). Most (88.0%) had at least 1 @entity3 criterion on admission, and 76 (37.3%) manifested additional @entity3 criteria over time. Risks of admission to HDU/ICU (3.3%) and of 30-day mortality (5.7%) were low. The proportion of @entity0 with at least 1 @entity3 criterion, mean CRP, and mean WBC all decreased over time. Multivariable regression models identified days since hospital admission as the only variable associated with daily presence of @entity3 criteria, WCC, or @entity4 and p < 0.0001 in all analyses). Statin exposure was not a significant predictor. CONCLUSIONS: This cohort of ward @entity0 treated for @entity2 had a low risk of clinical deterioration, inflammatory markers improved over time, and statin exposure was not associated with any outcome. Future larger studies may identify risk factors for progression of illness in this population and plausible surrogate endpoints for evaluation in clinical trials.

title: The influence of statin exposure on inflammatory markers in XXXX with early bacterial infection: pilot prospective cohort study.

answer: @entity0