abstract: INTRODUCTION: @entity2 ( @entity2 ) ablation is an effective option in @entity0 undergoing ablation for persistent @entity4 ( @entity4 ). Achieving bidirectional conduction block across the @entity2 is challenging, and predictors of @entity2 ablation success remain incompletely understood. We sought to determine the impact of anatomical location of the ablation line on the efficacy of @entity2 ablation. METHODS AND RESULTS: A total of 40 consecutive @entity0 (87% male; 54    10 years) undergoing stepwise @entity4 ablation were included. @entity2 ablation was performed in sinus rhythm. @entity2 ablation was performed from the left inferior PV to either the posterior (group 1) or the anterolateral (group 2) mitral annulus depending on randomization. The length of the @entity2 line (measured with the 3D mapping system) and the amplitude of the EGMs at 3 positions on the @entity2 were measured in each @entity0 . @entity3 was achieved in 14/19 (74%) @entity0 in group 1 and 15/21 (71%) @entity0 in group 2 (P = NS). Total @entity2 radiofrequency time (18    7  min vs. 17    8 min; P = NS) was similar between groups. @entity0 with incomplete @entity3 had a longer @entity2 length (34    6 mm vs. 24    5 mm; P < 0.001), a @entity1 along the @entity2 (1.75    0.74  mV vs. 1.05    0.69 mV; P < 0.01), and a longer history of continuous @entity4 (19    17 months vs. 10    10 months; P < 0.05). In multivariate analysis, decreased length of the @entity2 was an independent predictor of successful @entity3 (OR 1.5; 95% CI 1.1-2.1; P < 0.05). CONCLUSIONS: Increased length but not anatomical location of the @entity2 predicts failure to achieve bidirectional @entity3 during ablation of persistent @entity4 .

title: Length of the Mitral Isthmus But Not Anatomical Location of Ablation Line Predicts Bidirectional Mitral Isthmus Block in @entity0 Undergoing Catheter Ablation of Persistent XXXX : A Randomized Controlled Trial.

answer: @entity4


abstract: INTRODUCTION: @entity2 ( @entity2 ) ablation is an effective option in @entity0 undergoing ablation for persistent @entity4 ( @entity4 ). Achieving bidirectional conduction block across the @entity2 is challenging, and predictors of @entity2 ablation success remain incompletely understood. We sought to determine the impact of anatomical location of the ablation line on the efficacy of @entity2 ablation. METHODS AND RESULTS: A total of 40 consecutive @entity0 (87% male; 54    10 years) undergoing stepwise @entity4 ablation were included. @entity2 ablation was performed in sinus rhythm. @entity2 ablation was performed from the left inferior PV to either the posterior (group 1) or the anterolateral (group 2) mitral annulus depending on randomization. The length of the @entity2 line (measured with the 3D mapping system) and the amplitude of the EGMs at 3 positions on the @entity2 were measured in each @entity0 . @entity3 was achieved in 14/19 (74%) @entity0 in group 1 and 15/21 (71%) @entity0 in group 2 (P = NS). Total @entity2 radiofrequency time (18    7  min vs. 17    8 min; P = NS) was similar between groups. @entity0 with incomplete @entity3 had a longer @entity2 length (34    6 mm vs. 24    5 mm; P < 0.001), a @entity1 along the @entity2 (1.75    0.74  mV vs. 1.05    0.69 mV; P < 0.01), and a longer history of continuous @entity4 (19    17 months vs. 10    10 months; P < 0.05). In multivariate analysis, decreased length of the @entity2 was an independent predictor of successful @entity3 (OR 1.5; 95% CI 1.1-2.1; P < 0.05). CONCLUSIONS: Increased length but not anatomical location of the @entity2 predicts failure to achieve bidirectional @entity3 during ablation of persistent @entity4 .

title: Length of the Mitral Isthmus But Not Anatomical Location of Ablation Line Predicts Bidirectional Mitral Isthmus Block in XXXX Undergoing Catheter Ablation of Persistent @entity4 : A Randomized Controlled Trial.

answer: @entity0


abstract: Learning and memory processes are known to be influenced by the action of @entity1 (NE). The present study evaluated the influence of neonatal administration of the NE neurotoxin @entity2 on sensory preconditioning (SPC) in 16- and 28-day-old @entity0 . @entity0 were subcutaneously administered 50 mg/kg @entity2 or saline within 24 h after birth and tested at 16 or 28 days in two experiments. The results from Experiment 1 indicated that nondepleted 16-day-old @entity0 exhibited strong SPC, whereas this conditioning was disrupted by neonatal administration of @entity2 . No SPC was seen in either neonatal treatment group at 28 days of age, confirming previous reports of an ontogenetic decline in SPC. In Experiment 2, no effects of @entity2 were observed on first-order conditioning at either age. The brains of representative subjects were separated into forebrain, cerebellum, and brain stem samples and were analyzed to determine the extent of NE depletion. This analysis showed that @entity2 produced a marked reduction in NE concentration in the forebrain, but not in the cerebellum or brain stem. The results of this study suggest a role for forebrain NE in SPC in preweanling @entity0 . This modulatory noradrenergic influence appears to be exerted on the formation of associations between two relatively neutral stimuli during the preexposure phase, given the absence of an effect of @entity2 on primary conditioning.

title: Disruptive influence of XXXX depletion on sensory preconditioning, but not first-order conditioning, in preweanling @entity0 .

answer: @entity1


abstract: Learning and memory processes are known to be influenced by the action of @entity1 (NE). The present study evaluated the influence of neonatal administration of the NE neurotoxin @entity2 on sensory preconditioning (SPC) in 16- and 28-day-old @entity0 . @entity0 were subcutaneously administered 50 mg/kg @entity2 or saline within 24 h after birth and tested at 16 or 28 days in two experiments. The results from Experiment 1 indicated that nondepleted 16-day-old @entity0 exhibited strong SPC, whereas this conditioning was disrupted by neonatal administration of @entity2 . No SPC was seen in either neonatal treatment group at 28 days of age, confirming previous reports of an ontogenetic decline in SPC. In Experiment 2, no effects of @entity2 were observed on first-order conditioning at either age. The brains of representative subjects were separated into forebrain, cerebellum, and brain stem samples and were analyzed to determine the extent of NE depletion. This analysis showed that @entity2 produced a marked reduction in NE concentration in the forebrain, but not in the cerebellum or brain stem. The results of this study suggest a role for forebrain NE in SPC in preweanling @entity0 . This modulatory noradrenergic influence appears to be exerted on the formation of associations between two relatively neutral stimuli during the preexposure phase, given the absence of an effect of @entity2 on primary conditioning.

title: Disruptive influence of @entity1 depletion on sensory preconditioning, but not first-order conditioning, in preweanling XXXX .

answer: @entity0


abstract: Although there have been no major breakthroughs in @entity9 therapy, new treatments have been tested in @entity0 with @entity5 , including both interferon alfa and @entity3 . These biologic agents can reduce collagen synthesis, which is a rational target for @entity9 therapy. Debate about the use of photopheresis continues, and it was suggested in a recent editorial that photopheresis is no better than @entity6 in the treatment of @entity9 and is more expensive. @entity2 appears to have frequent @entity1 when used to treat @entity9 . Outcome measurements have been concentrated on in @entity9 trials. Several types of @entity9 classifications were compared, and the classification of diffuse and limited @entity9 was strongly related to disease severity. Skin score was systematically compared with mapping the surface area of involved skin, and the skin score was found to be more reliable. A possible prognostic indicator in @entity9 is high-resolution pulmonary computed tomography, which is sensitive in early detection of @entity9 -associated @entity4 . Classification of @entity7 into primary and secondary forms has been proposed, and further testing of the criteria and long-term follow-up is necessary to validate this classification. Over the past year, treatment of @entity8 with @entity10 analogues has been efficacious with iloprost but not with low-dose oral cicaprost. Tissue plasminogen activator is not beneficial in the treatment of @entity7 . A report of radical microarteriolysis for the treatment of refractory @entity7 seems promising, warranting further investigation.

title: Treatment of XXXX .

answer: @entity5


abstract: BACKGROUND: We previously cloned a 1,3-specific lipase gene from the fungus Rhizomucor miehei and expressed it in methylotrophic @entity0 @entity5 . The enzyme produced (termed RML) was able to catalyze methanolysis of @entity3 oil and showed strong position specificity. However, the enzyme activity and amount of enzyme produced were not adequate for industrial application. Our goal in the present study was to improve the enzyme properties of RML in order to apply it for the conversion of microalgae oil to biofuel. RESULTS: Several new expression plasmids were constructed by adding the propeptide of the target gene, optimizing the signal peptide, and varying the number of target gene copies. Each plasmid was transformed separately into @entity4 X-33. Screening by flask culture showed maximal (21.4-fold increased) enzyme activity for the recombinant strain with two copies of the target gene; the enzyme was termed Lipase GH2. The expressed protein with the propeptide (pRML) was a stable glycosylated protein, because of glycosylation sites in the propeptide. Quantitative real-time RT-PCR analysis revealed two major reasons for the increase in enzyme activity: (1) the modified recombinant expression system gave an increased transcription level of the target gene (rml), and (2) the enzyme was suitable for expression in host cells without causing endoplasmic reticulum (ER) stress. The modified enzyme had improved thermostability and @entity1 or @entity2 tolerance, and was applicable directly as free lipase (fermentation supernatant) in the catalytic esterification and transesterification reaction. After reaction for 24 hours at 30  C, the conversion rate of microalgae oil to biofuel was above 90%. CONCLUSIONS: Our experimental results show that signal peptide optimization in the expression plasmid, addition of the gene propeptide, and proper gene dosage significantly increased RML expression level and enhanced the enzymatic properties. The target enzyme was the major component of fermentation supernatant and was stable for over six months at 4  C. The modified free lipase is potentially applicable for industrial-scale conversion of microalgae oil to biodiesel.

title: Improved production of a recombinant Rhizomucor miehei lipase expressed in XXXX and its application for conversion of microalgae oil to biodiesel.

answer: @entity4


abstract: BACKGROUND: Skull base @entity1 comprise many common @entity4 . Treatment has advanced, allowing many survivors to return to work. However, literature is limited about the neuropsychological status of these @entity0 prior to treatment. Literature pertaining to the relationship between neuropsychological functioning and occupational ability prior to surgical intervention is even more limited. The purpose of this analysis was to evaluate the impact of neuropsychological function on work productivity in @entity0 with @entity1 prior to resection. METHODS: Neuropsychological function and work productivity were assessed in adults newly diagnosed with @entity1 (n = 45) prior to surgical intervention. Univariate analyses identified potential predictors of work limitations; variables with P < .10 were analyzed using multivariate regression analyses controlled for age, sex, @entity1 type, and education. RESULTS: Poorer @entity3 (MF) and higher @entity2 ( @entity2 ) were significantly associated with poor time management at work (MF: b = -0.59, P = .01; @entity2 : b = 3.42, P < .01; R (2) = 0.54). Difficulty meeting physical work demands was significantly associated with poorer visuospatial ability (VA) and higher @entity2 (VA: b = -3.30, P = .05; @entity2 : b = 2.29, P < .01; R (2) = 0.29). Lower learning and memory scores (LM) and higher @entity2 were significantly associated with difficulty meeting mental-interpersonal work demands (LM: b = -3.39, P = .04; @entity2 : b = 3.25, P < .01; R (2) = 0.47) and overall health-related loss of work productivity (LM: b = -0.72, P = .05; @entity2 : b = 0.659, P < .001; R (2) = 0.43). CONCLUSION: Domains of neuropsychological function that predicted work productivity were identified. Future research should examine neuropsychological function, @entity2 , and work productivity across the care trajectory from diagnosis through long-term survivorship.

title: Work productivity and neuropsychological function in @entity0 with XXXX .

answer: @entity1


abstract: BACKGROUND: Skull base @entity1 comprise many common @entity4 . Treatment has advanced, allowing many survivors to return to work. However, literature is limited about the neuropsychological status of these @entity0 prior to treatment. Literature pertaining to the relationship between neuropsychological functioning and occupational ability prior to surgical intervention is even more limited. The purpose of this analysis was to evaluate the impact of neuropsychological function on work productivity in @entity0 with @entity1 prior to resection. METHODS: Neuropsychological function and work productivity were assessed in adults newly diagnosed with @entity1 (n = 45) prior to surgical intervention. Univariate analyses identified potential predictors of work limitations; variables with P < .10 were analyzed using multivariate regression analyses controlled for age, sex, @entity1 type, and education. RESULTS: Poorer @entity3 (MF) and higher @entity2 ( @entity2 ) were significantly associated with poor time management at work (MF: b = -0.59, P = .01; @entity2 : b = 3.42, P < .01; R (2) = 0.54). Difficulty meeting physical work demands was significantly associated with poorer visuospatial ability (VA) and higher @entity2 (VA: b = -3.30, P = .05; @entity2 : b = 2.29, P < .01; R (2) = 0.29). Lower learning and memory scores (LM) and higher @entity2 were significantly associated with difficulty meeting mental-interpersonal work demands (LM: b = -3.39, P = .04; @entity2 : b = 3.25, P < .01; R (2) = 0.47) and overall health-related loss of work productivity (LM: b = -0.72, P = .05; @entity2 : b = 0.659, P < .001; R (2) = 0.43). CONCLUSION: Domains of neuropsychological function that predicted work productivity were identified. Future research should examine neuropsychological function, @entity2 , and work productivity across the care trajectory from diagnosis through long-term survivorship.

title: Work productivity and neuropsychological function in XXXX with @entity1 .

answer: @entity0


abstract: @entity2 ( @entity2 ) in a kidney allograft is rare. We report the successful diagnosis and treatment of a de novo @entity2 in a nonfunctioning kidney transplant 20 years after engraftment. A 54-year-old @entity0 received a kidney transplant from his mother when he was 34 years old. After 10 years, chronic rejection resulted in graft failure, and the @entity0 became hemodialysis-dependent. Intravenous contrast-enhanced computed tomography (CT) for the evaluation of gastrointestinal symptoms revealed a solid 13   mm @entity1 in the kidney graft. The @entity1 was confirmed on ultrasound examination. This @entity1 had not been detected on a surveillance noncontrast CT scan. Needle biopsy showed that the @entity1 was an @entity2 . Allograft nephrectomy was performed. Pathological examination showed that the @entity1 was a Fuhrman Grade 2 @entity2 . XY-fluorescence hybridization analysis of the @entity2 showed that the @entity1 cells were of donor origin. One year after the surgery, the @entity0 is alive and has no evidence of @entity1 recurrence. Regardless of whether a kidney transplant is functioning, it should periodically be imaged for @entity2 throughout the recipient's lifetime. In our experience, ultrasonography or CT with intravenous contrast is better than CT without contrast for the detection of @entity1 in a nonfunctioning kidney transplant.

title: De novo XXXX in a kidney allograft 20 years after transplant.

answer: @entity2


abstract: Immunohistochemical methods have been used to determine the distribution of macroglia and myelin in the normal @entity0 superior colliculus (SC) and in grafts of fetal tectal tissue. The fetal tissue was derived from 15 day-old (E15) @entity0 embryos and was transplanted onto the midbrain of newborn host @entity0 of the same (PVG/c) strain. Antibodies to @entity1 ( @entity1 ) and @entity2 ( @entity2 ) were used to visualize astrocytes and oligodendroglia respectively. Myelin was immunostained with antibodies to either proteolipid protein ( @entity5 ) or @entity4 ( @entity4 ). In the normal SC, @entity1 positive astrocytes were found scattered throughout the SC, particularly in the superficial layers. They were especially prominent at the pial surface, around major blood vessels and at the midline between the two colliculi. @entity2 immunoreactive oligodendroglia and associated myelin were also found throughout the SC; by far the lowest density was seen in the stratum griseum superficiale (SGS). Both types of macroglia cell were found in abundance in tectal transplants, indicating that the precursors of these glial types were present in the E15 @entity0 mesencephalon. In mature grafts, large numbers of fibrous astrocytes were found throughout the neuropil and the level of @entity1 immunoreactivity was consistently greater than in host SC. Astrocytes seemed to be maintained in a reactive, perhaps immature state within the grafted tissue. Tectal transplants possessed large numbers of fully differentiated @entity2 -positive oligodendroglia and the grafts contained a dense network of myelinated axons. However the distribution of @entity2 and @entity5 immunoreactivity was not homogeneous; there were localized, well-defined regions that contained few oligodendroglia and relatively little myelin. These areas stained intensely for @entity3 ( @entity3 ) and were almost certainly homologous to the SGS of normal SC. The relative lack of oligodendroglia in the @entity3 stained patches in grafts and in SGS in situ suggests that local factors influencing the proliferation and distribution of oligodendroglia in normal SC may have been operating in a similar manner within the tectal transplant neuropil.

title: The distribution of astrocytes, oligodendroglia and myelin in normal and transplanted XXXX superior colliculus: an immunohistochemical study.

answer: @entity0


abstract: BACKGROUND: Infarct size is an important surrogate end point for early and late mortality after @entity4 . Despite the high prevalence of @entity2 in @entity0 with @entity5 , adequate data are still lacking regarding the extent of @entity3 after @entity4 in these @entity0 . OBJECTIVES: In the present study we aimed to compare @entity4 size in @entity0 with @entity2 to those without @entity2 using peak CK-MB and @entity7 ( @entity7 ) at 72 hours after the onset of symptoms. @entity0 AND METHODS: One-hundred @entity0 with @entity2 (group I) and 100 control subjects without @entity2 (group II) who experienced @entity4 were included in the study. Diagnosis of @entity2 was based on the National @entity1 Education Program Adult Treatment Panel III (NCEP ATP III) guidelines published in 2001. @entity4 size was compared between the two groups of @entity0 using peak CK-MB and @entity7 level in 72 hours after the onset of symptoms. RESULTS: Peak CK-MB and @entity7 in 72 hours were found to be significantly higher in @entity0 with @entity2 compared with control subjects (both P < 0.001). @entity0 with @entity2 also had markedly higher wall motion abnormality at 72 hours after the onset of symptoms as assessed by echocardiographically-derived Wall Motion Score Index (WMSI) (P < 0.001). Moreover, statistically significant relationships were found between WMSI and peak CK-MB and also @entity7 at 72 hours (Spearman's rho = 0.56, P < 0.001 and Spearman's rho = 0.5, P < 0.001; respectively). However, association between WMSI and left ventricular ejection fraction was insignificant (Spearman's rho = -0.05, P = 0.46). CONCLUSIONS: We showed that @entity0 with @entity2 have larger @entity6 size compared to control subjects.

title: XXXX is Associated With Higher Wall Motion Score and Larger Infarct Size After Acute @entity4 .

answer: @entity2


abstract: BACKGROUND: Infarct size is an important surrogate end point for early and late mortality after @entity4 . Despite the high prevalence of @entity2 in @entity0 with @entity5 , adequate data are still lacking regarding the extent of @entity3 after @entity4 in these @entity0 . OBJECTIVES: In the present study we aimed to compare @entity4 size in @entity0 with @entity2 to those without @entity2 using peak CK-MB and @entity7 ( @entity7 ) at 72 hours after the onset of symptoms. @entity0 AND METHODS: One-hundred @entity0 with @entity2 (group I) and 100 control subjects without @entity2 (group II) who experienced @entity4 were included in the study. Diagnosis of @entity2 was based on the National @entity1 Education Program Adult Treatment Panel III (NCEP ATP III) guidelines published in 2001. @entity4 size was compared between the two groups of @entity0 using peak CK-MB and @entity7 level in 72 hours after the onset of symptoms. RESULTS: Peak CK-MB and @entity7 in 72 hours were found to be significantly higher in @entity0 with @entity2 compared with control subjects (both P < 0.001). @entity0 with @entity2 also had markedly higher wall motion abnormality at 72 hours after the onset of symptoms as assessed by echocardiographically-derived Wall Motion Score Index (WMSI) (P < 0.001). Moreover, statistically significant relationships were found between WMSI and peak CK-MB and also @entity7 at 72 hours (Spearman's rho = 0.56, P < 0.001 and Spearman's rho = 0.5, P < 0.001; respectively). However, association between WMSI and left ventricular ejection fraction was insignificant (Spearman's rho = -0.05, P = 0.46). CONCLUSIONS: We showed that @entity0 with @entity2 have larger @entity6 size compared to control subjects.

title: @entity2 is Associated With Higher Wall Motion Score and Larger Infarct Size After Acute XXXX .

answer: @entity4


abstract: BACKGROUND: @entity3 ( @entity6 ) is a localized or diffuse abnormal dilatation of coronary arteries. Controversy still remains about its cardiovascular events rate, prognosis, and etiology. Adverse effects of @entity6 coinciding with @entity9 ( @entity9 ) (and in isolated form) are unclear. OBJECTIVES: We aimed to investigate the cardiovascular event rate of @entity6 in comparison to ' @entity9 only', and comparing their etiology. @entity0 AND METHODS: This cross-sectional study was conducted on 200 @entity0 between May 2011 and June 2012. Of them, 40 had @entity6 ( @entity6 ) and 160 had only @entity9 (control group). @entity0 with @entity6 were divided into 2 subgroups according to the absence (E1) or presence (E2) of @entity9 . They were followed up for at least 6 month for cardiovascular events, including death, unstable @entity5 and @entity4 ( @entity4 ). Finally, we compared findings in @entity6 , @entity9 , and @entity11 2 subgroups and evaluated the relationship between severity of @entity10 (1-1.5 times, 1.5-2 times, and > 2 times) and @entity9 . RESULTS: @entity2 ( @entity2 ), @entity7 ( @entity7 ), and male sex were matched in both groups without significant difference. Cigarette smoking (C/S) was significantly higher and @entity1 ( @entity1 ) was significantly lower in @entity6 compared to @entity9 @entity0 . A subgroup of @entity6 @entity0 with @entity9 (E2 subgroup) had significantly higher mortality rate than isolated @entity9 (P = 0.043). @entity4 was seen in several @entity8 @entity0 (E1) subgroup. Severity of @entity10 showed no significant relationship with @entity9 . CONCLUSIONS: Presence of @entity6 in @entity0 with @entity9 increases its cardiovascular event rate. Isolated @entity6 is not a benign finding and @entity4 can occur. Risk factors of @entity6 are similar to @entity9 , but C/S is more associated with @entity6 than @entity9 . @entity1 is seen in @entity6 @entity0 less than @entity9 .

title: Comparison of outcomes of diseased XXXX , stenosis and combined.

answer: @entity3


abstract: BACKGROUND: The best treatment for scaphoid nonunion fractures is still controversial. The main aim of this study was to determine the results of the modified Matti-Russe method of surgery on scaphoid nonunion. MATERIALS AND METHODS: In this prospective interventional study, 30 @entity0 with nonunion @entity1 recruited from clinics of the Isfahan University of Medical Sciences between October 2007 and March 2011 underwent the modified Matti-Russe method of surgery. Union rate was evaluated four and six months after the procedure. @entity2 ( @entity2 ) was calculated for the subjects six months after surgery. RESULTS: Mean age of the subjects was 25.9    7.8 years, ranging from 16 to 35 years. Twenty-seven (90%) were @entity0 , and three (10%) were @entity0 . Four and six months after surgery, 10 (33%) and 26 (86.7%) subjects had a united @entity1 . Mean @entity2 was 75.0    8.8 in all the subjects, ranging from 54 to 90 six months after surgery. Three subjects (10%) were grouped as excellent, 9 (30%) good, 16 (53.3%) satisfactory, and 3 (6.7%) poor. CONCLUSION: A @entity1 or nonunion of the scaphoid bone can be a complex and troubling injury, but the modified Matti-Russe method showed satisfactory results six months after surgery.

title: Scaphoid nonunion XXXX and results of the modified Matti-Russe technique.

answer: @entity1


abstract: OBJECTIVE: Studies in animals have indicated that increased production of @entity5 from an inducible isoform of @entity5 synthase contributes to the pathophysiology of endotoxic and cytokine induced shock. The aim of this study was to determine the role of @entity5 in @entity2 in @entity0 . METHODS: The study was a randomised, double blind, placebo controlled investigation of the effects of the @entity5 synthase inhibitor @entity7 ( @entity7 ) in 12 @entity0 with severe @entity1 associated with @entity4 . Measurements of haemodynamic, haematological, and biochemical variables were made. RESULTS: @entity7 (0.3 and 1 mg.kg-1) produced a dose dependent increase in mean arterial pressure, systemic vascular resistance, pulmonary vascular resistance, central venous pressure, and @entity3 , and a decrease in cardiac output and heart rate. In response to the highest dose of @entity7 systemic vascular resistance increased from 547(SEM 92) to 889(143) dyne.s.cm-5, mean arterial blood pressure increased from 80.9(2.9) to 100.5(6.1) mm Hg, and cardiac output decreased from 11.2(2.1) to 8.9(1.9) litres. @entity6 . Continuous infusion of @entity7 (1 mg.kg-1 x h-1) produced sustained haemodynamic changes. Platelet numbers decreased during the course of the study in both the @entity7 and the placebo group and did not differ significantly between the groups. CONCLUSIONS: Low doses of @entity7 cause a widespread increase in vascular tone and raise blood pressure in @entity0 with @entity2 . Overproduction of @entity5 appears to be an important mechanism in @entity2 in @entity0 , and inhibition of @entity5 synthesis might provide a novel therapeutic approach to this condition. However, @entity7 produced a fall in cardiac output and it is possible that this would worsen tissue perfusion. Larger studies examining the effects of @entity7 on mortality and morbidity are now required.

title: Effects of a XXXX synthase inhibitor in @entity0 with @entity2 .

answer: @entity5


abstract: OBJECTIVE: Studies in animals have indicated that increased production of @entity5 from an inducible isoform of @entity5 synthase contributes to the pathophysiology of endotoxic and cytokine induced shock. The aim of this study was to determine the role of @entity5 in @entity2 in @entity0 . METHODS: The study was a randomised, double blind, placebo controlled investigation of the effects of the @entity5 synthase inhibitor @entity7 ( @entity7 ) in 12 @entity0 with severe @entity1 associated with @entity4 . Measurements of haemodynamic, haematological, and biochemical variables were made. RESULTS: @entity7 (0.3 and 1 mg.kg-1) produced a dose dependent increase in mean arterial pressure, systemic vascular resistance, pulmonary vascular resistance, central venous pressure, and @entity3 , and a decrease in cardiac output and heart rate. In response to the highest dose of @entity7 systemic vascular resistance increased from 547(SEM 92) to 889(143) dyne.s.cm-5, mean arterial blood pressure increased from 80.9(2.9) to 100.5(6.1) mm Hg, and cardiac output decreased from 11.2(2.1) to 8.9(1.9) litres. @entity6 . Continuous infusion of @entity7 (1 mg.kg-1 x h-1) produced sustained haemodynamic changes. Platelet numbers decreased during the course of the study in both the @entity7 and the placebo group and did not differ significantly between the groups. CONCLUSIONS: Low doses of @entity7 cause a widespread increase in vascular tone and raise blood pressure in @entity0 with @entity2 . Overproduction of @entity5 appears to be an important mechanism in @entity2 in @entity0 , and inhibition of @entity5 synthesis might provide a novel therapeutic approach to this condition. However, @entity7 produced a fall in cardiac output and it is possible that this would worsen tissue perfusion. Larger studies examining the effects of @entity7 on mortality and morbidity are now required.

title: Effects of a @entity5 synthase inhibitor in @entity0 with XXXX .

answer: @entity2


abstract: OBJECTIVE: Studies in animals have indicated that increased production of @entity5 from an inducible isoform of @entity5 synthase contributes to the pathophysiology of endotoxic and cytokine induced shock. The aim of this study was to determine the role of @entity5 in @entity2 in @entity0 . METHODS: The study was a randomised, double blind, placebo controlled investigation of the effects of the @entity5 synthase inhibitor @entity7 ( @entity7 ) in 12 @entity0 with severe @entity1 associated with @entity4 . Measurements of haemodynamic, haematological, and biochemical variables were made. RESULTS: @entity7 (0.3 and 1 mg.kg-1) produced a dose dependent increase in mean arterial pressure, systemic vascular resistance, pulmonary vascular resistance, central venous pressure, and @entity3 , and a decrease in cardiac output and heart rate. In response to the highest dose of @entity7 systemic vascular resistance increased from 547(SEM 92) to 889(143) dyne.s.cm-5, mean arterial blood pressure increased from 80.9(2.9) to 100.5(6.1) mm Hg, and cardiac output decreased from 11.2(2.1) to 8.9(1.9) litres. @entity6 . Continuous infusion of @entity7 (1 mg.kg-1 x h-1) produced sustained haemodynamic changes. Platelet numbers decreased during the course of the study in both the @entity7 and the placebo group and did not differ significantly between the groups. CONCLUSIONS: Low doses of @entity7 cause a widespread increase in vascular tone and raise blood pressure in @entity0 with @entity2 . Overproduction of @entity5 appears to be an important mechanism in @entity2 in @entity0 , and inhibition of @entity5 synthesis might provide a novel therapeutic approach to this condition. However, @entity7 produced a fall in cardiac output and it is possible that this would worsen tissue perfusion. Larger studies examining the effects of @entity7 on mortality and morbidity are now required.

title: Effects of a @entity5 synthase inhibitor in XXXX with @entity2 .

answer: @entity0


abstract: Enriched progenitor cell fractions from @entity0 bone marrow were induced to undergo myeloid maturation in culture using recombinant @entity0 @entity5 (rhGM-CSF). A negative selection method using the murine monoclonal antibodies (MABs) PM81 (anti- @entity9 ), AML-2-23 (anti- @entity8 ), PC251 (anti- @entity3 ), OKT11 (anti- @entity6 ), and SCCL-1 (anti- @entity10 ) and immunomagnetic beads coated with sheep anti-mouse IgG (Dynal A.S., Oslo, Norway) was used to remove the more mature cellular components of mononuclear cells from normal donor bone marrow samples. The resulting fraction of cells contained 35 to 40% @entity4 -positive cells, and less than 1% of cells expressed the receptors for the constant portion of immunoglobulin G @entity11 or Fc gamma RII. A small population (3-5%) expressed @entity7 on day 0, and these cells were found by two-color flow cytometry to be primarily natural killer (NK) cells. The level of Fc gamma R expression was determined every 2 to 3 days on aliquots of the differentiating cells. Thirteen percent of the cultured bone marrow cells expressed Fc gamma RII after 48 hours in liquid culture with rhIL-3 and rhGM-CSF. The percent of cells expressing Fc gamma RII increased to a peak of 78% of the gated population on day 10. The mean fluorescence intensity (MFI) remained low for the first 8 to 10 days of culture, but at that time the MFI more than doubled. @entity11 and @entity7 expression remained low throughout the culture period. The ability of the differentiating cells to perform @entity1 ( @entity1 ) was determined at a single-cell level in a modified plaque assay using monolayers of ox erythrocyte (oxE) target cells. The purified progenitor cells, when placed in oxE monolayers sensitized with polyclonal rabbit anti-oxE @entity2 ( @entity2 ), showed no plaque formation over control oxE layers. No increase in ability to generate cytolytic plaques in @entity2 -sensitized oxE layers was seen compared with unsensitized oxE layers until after 10 days of incubation in liquid culture. At that time, the percent of cells forming plaques in the @entity2 -sensitized oxE layers was 34.4 +/- 10.7% (average +/- standard error of the mean [SEM]; n = 4) compared with 10.0 +/- 0.7% on the control oxE layers. The peak plaque formation appeared to coincide with the increase in MFI of a large population of the cultured cells.(ABSTRACT TRUNCATED AT 400 WORDS)

title: The effect of recombinant @entity0 interleukin-3 and recombinant @entity0 granulocyte-macrophage colony-stimulating factor on Fc gamma receptor expression and XXXX of hematopoietic progenitor cells during in vitro myeloid maturation.

answer: @entity1


abstract: Enriched progenitor cell fractions from @entity0 bone marrow were induced to undergo myeloid maturation in culture using recombinant @entity0 @entity5 (rhGM-CSF). A negative selection method using the murine monoclonal antibodies (MABs) PM81 (anti- @entity9 ), AML-2-23 (anti- @entity8 ), PC251 (anti- @entity3 ), OKT11 (anti- @entity6 ), and SCCL-1 (anti- @entity10 ) and immunomagnetic beads coated with sheep anti-mouse IgG (Dynal A.S., Oslo, Norway) was used to remove the more mature cellular components of mononuclear cells from normal donor bone marrow samples. The resulting fraction of cells contained 35 to 40% @entity4 -positive cells, and less than 1% of cells expressed the receptors for the constant portion of immunoglobulin G @entity11 or Fc gamma RII. A small population (3-5%) expressed @entity7 on day 0, and these cells were found by two-color flow cytometry to be primarily natural killer (NK) cells. The level of Fc gamma R expression was determined every 2 to 3 days on aliquots of the differentiating cells. Thirteen percent of the cultured bone marrow cells expressed Fc gamma RII after 48 hours in liquid culture with rhIL-3 and rhGM-CSF. The percent of cells expressing Fc gamma RII increased to a peak of 78% of the gated population on day 10. The mean fluorescence intensity (MFI) remained low for the first 8 to 10 days of culture, but at that time the MFI more than doubled. @entity11 and @entity7 expression remained low throughout the culture period. The ability of the differentiating cells to perform @entity1 ( @entity1 ) was determined at a single-cell level in a modified plaque assay using monolayers of ox erythrocyte (oxE) target cells. The purified progenitor cells, when placed in oxE monolayers sensitized with polyclonal rabbit anti-oxE @entity2 ( @entity2 ), showed no plaque formation over control oxE layers. No increase in ability to generate cytolytic plaques in @entity2 -sensitized oxE layers was seen compared with unsensitized oxE layers until after 10 days of incubation in liquid culture. At that time, the percent of cells forming plaques in the @entity2 -sensitized oxE layers was 34.4 +/- 10.7% (average +/- standard error of the mean [SEM]; n = 4) compared with 10.0 +/- 0.7% on the control oxE layers. The peak plaque formation appeared to coincide with the increase in MFI of a large population of the cultured cells.(ABSTRACT TRUNCATED AT 400 WORDS)

title: The effect of recombinant XXXX interleukin-3 and recombinant @entity0 granulocyte-macrophage colony-stimulating factor on Fc gamma receptor expression and @entity1 of hematopoietic progenitor cells during in vitro myeloid maturation.

answer: @entity0


abstract: Enriched progenitor cell fractions from @entity0 bone marrow were induced to undergo myeloid maturation in culture using recombinant @entity0 @entity5 (rhGM-CSF). A negative selection method using the murine monoclonal antibodies (MABs) PM81 (anti- @entity9 ), AML-2-23 (anti- @entity8 ), PC251 (anti- @entity3 ), OKT11 (anti- @entity6 ), and SCCL-1 (anti- @entity10 ) and immunomagnetic beads coated with sheep anti-mouse IgG (Dynal A.S., Oslo, Norway) was used to remove the more mature cellular components of mononuclear cells from normal donor bone marrow samples. The resulting fraction of cells contained 35 to 40% @entity4 -positive cells, and less than 1% of cells expressed the receptors for the constant portion of immunoglobulin G @entity11 or Fc gamma RII. A small population (3-5%) expressed @entity7 on day 0, and these cells were found by two-color flow cytometry to be primarily natural killer (NK) cells. The level of Fc gamma R expression was determined every 2 to 3 days on aliquots of the differentiating cells. Thirteen percent of the cultured bone marrow cells expressed Fc gamma RII after 48 hours in liquid culture with rhIL-3 and rhGM-CSF. The percent of cells expressing Fc gamma RII increased to a peak of 78% of the gated population on day 10. The mean fluorescence intensity (MFI) remained low for the first 8 to 10 days of culture, but at that time the MFI more than doubled. @entity11 and @entity7 expression remained low throughout the culture period. The ability of the differentiating cells to perform @entity1 ( @entity1 ) was determined at a single-cell level in a modified plaque assay using monolayers of ox erythrocyte (oxE) target cells. The purified progenitor cells, when placed in oxE monolayers sensitized with polyclonal rabbit anti-oxE @entity2 ( @entity2 ), showed no plaque formation over control oxE layers. No increase in ability to generate cytolytic plaques in @entity2 -sensitized oxE layers was seen compared with unsensitized oxE layers until after 10 days of incubation in liquid culture. At that time, the percent of cells forming plaques in the @entity2 -sensitized oxE layers was 34.4 +/- 10.7% (average +/- standard error of the mean [SEM]; n = 4) compared with 10.0 +/- 0.7% on the control oxE layers. The peak plaque formation appeared to coincide with the increase in MFI of a large population of the cultured cells.(ABSTRACT TRUNCATED AT 400 WORDS)

title: The effect of recombinant @entity0 interleukin-3 and recombinant XXXX granulocyte-macrophage colony-stimulating factor on Fc gamma receptor expression and @entity1 of hematopoietic progenitor cells during in vitro myeloid maturation.

answer: @entity0


abstract: Background: @entity2 testing is being used extensively in countries with a high burden of @entity1 . However recent evidence suggests that it may not have the same accuracy or impact in high-income, low-burden @entity1 countries. Methods: A prospective, pragmatic study was done between March 2012 and March 2014 to determine the feasibility, test accuracy, and impact on @entity1 disease management provided by the Xpert test in a remote, medically underserved, predominantly Inuit population in Iqaluit, Nunavut, Canada. Main Results: A total of 453 Xpert tests were run on sputum samples from 344 @entity0 with suspected @entity1 . Twenty seven @entity0 were identified as having active @entity1 disease by culture. There were no cases of drug resistant @entity1 . Using culture as the gold standard, one Xpert test compared to 1,2 or 3 sputum samples cultured per @entity0 , had a sensitivity of 85% (66-95, CI 95%) and a specificity = 99% (97-100, CI 95%) for detection of MTB. The indeterminate rate was 4.4% of all samples run. Treatment initiation was significantly shortened using Xpert versus the national standard of three smears (1.8 vs 7.7 days, p <0.007), and particularly shorter in smear-negative, culture-positive cases (1.8 vs 37.1 days, p value< 0.008). Conclusions: In a predominantly Inuit population in a remote region of Canada where the burden of @entity1 is high and no @entity1 testing facilities are available, on-site Xpert was feasible, accurate and shortened time to @entity1 treatment initiation.

title: The feasibility, accuracy and impact of XXXX testing in a remote Aboriginal community in Canada.

answer: @entity2


abstract: PURPOSE: We report a prospective randomized study comparing the relative efficacy of alternating chemotherapy @entity7 , @entity5 , @entity8 , and @entity1 / @entity2 , @entity4 , @entity10 , and @entity6 (MOPP/ABVD) with the standard MOPP chemotherapy in @entity0 with stage IIIB and IV @entity3 ( @entity3 ). The purpose is to study the influence of time of remission on clinical outcome. @entity0 AND METHODS: After two courses of MOPP, @entity0 were randomized to receive six further courses of MOPP, or two courses of ABVD followed by two courses of MOPP and two courses of ABVD. Radiotherapy was given to areas presenting with masses > or = 5 cm and to residual masses after course no. 4. Evaluation of response (complete remission [CR]) took place after two courses ( @entity11 ), after four courses ( @entity12 ), at the end of chemotherapy (CR8), and after additional radiotherapy (CR(CT + RT)). Logistic regression analysis was used to study prognostic factors for response at the end of chemotherapy. Cox analysis was used to study prognostic factors for survival. Two hundred seven @entity0 were registered, 192 (93%) of whom were randomized. RESULTS: The CR rate at the end of chemotherapy (CR8) was similar in both arms (57% v 59%). However, there were more progressions in the MOPP arm compared with the MOPP/ABVD arm (23% v 8%, P = .014). A significantly higher failure-free survival (FFS) rate was found in the MOPP/ABVD arm (60% v 43% at 6 years, P = .025). There was no difference in the @entity9 ( @entity9 ) or survival rate. Of @entity0 not in @entity12 , only 28% still reached a CR8. @entity9 at 6 years of @entity0 with @entity12 (69%) was not different from that of @entity0 with CR8 (68%); @entity0 with a CR(CT + RT)) had a lower @entity9 rate (48%). @entity12 (P < .001) predicted strongly for final remission at the end of chemotherapy. Cox analysis showed that age more than 50 years, six or more involved lymph node areas, no CR by the fourth cycle, chemotherapy with MOPP alone, and no radiotherapy were unfavorable factors for survival. CONCLUSION: MOPP/ABVD chemotherapy significantly improved response and FFS rates, but had no influence on @entity9 and survival rates. Early CR ( @entity12 ) is an important factor for final remission and might be used to select a group of @entity0 with a good prognosis.

title: A randomized study in stage IIIB and IV XXXX comparing eight courses of MOPP versus an alteration of MOPP with ABVD: a European Organization for Research and Treatment of Cancer Lymphoma Cooperative Group and Groupe Pierre-et-Marie-Curie controlled clinical trial.

answer: @entity3


abstract: UNASSIGNED: Psoriasis is clinically heterogeneous, and symptoms can vary from mild almost cosmetic symptoms to severe disease requiring systemic therapy. Biomarkers predicting disease development are lacking. Herein we explored the genetic background in two polarized cohorts of carefully phenotyped @entity0 with long-term follow-up: consistent mild phenotype (n=696) and severe disease course requiring systemic therapy (n=715). All @entity0 were treated at the same dermatology department ensuring homogenous assessment. Genotyping included known @entity1 -associated variants, with special focus on the @entity3 and NF-kB pathways. A case-case study comparing severe and mild @entity1 phenotypes, controlling for age at disease onset and gender, revealed significant differences between the two groups for SNPs in @entity4 , @entity2 , @entity5 , @entity6 , @entity8 and @entity3 . @entity7 *06 associated equally in the mild and severe disease cohorts. Strong additive effects when combining @entity7 *06 with @entity3 , @entity4 , @entity6 , @entity2 or @entity9 were restricted to the severe cohort, indicating that activation of these pathways may influence disease severity in @entity1 . No protective gene was identified in the mild cohort, suggesting that current screens have primarily identified @entity1 variants associated with a more severe phenotype. These results demonstrate the importance of careful phenotyping and long-term clinical follow-up in genetic studies.

title: Association with Genetic Variants in the XXXX and NF-kB Pathways Discriminates between Mild and Severe Psoriasis Skin Disease.

answer: @entity3


abstract: PURPOSE: The purpose of this study was to compare the dose to heart, left anterior descending (LAD) artery and lung between proton and photon beam irradiation for left-sided early stage @entity0 . MATERIAL AND METHODS: Ten @entity1 with early stage left-sided @entity0 were treated with breast conserving surgery and radiation. Whole breast radiation was delivered for actual treatment via a tangential technique with deep inspiration breath hold (DIBH) utilizing inverse planned intensity-modulated radiation therapy (IMRT). Each @entity1 was replanned on an Institutional Review Board (IRB)-approved prospective study using en face proton beam radiation with both uniform scanning (US) and @entity2 ( @entity2 ) techniques. RESULTS: Both @entity2 (0.011 Gy) and US (0.009 Gy) proton plans resulted in a significantly lower mean heart dose compared to IMRT (1.612 Gy) (p < 0.05 for @entity2 vs. IMRT and US vs. IMRT). The Dmean, Dmin, Dmax, and D0.2cm(3) of the LAD with either proton technique were significantly lower (p = 0.005) compared to IMRT. Both US and @entity2 reduced the mean dose to the lungs compared to IMRT. The coverage of the breast planning target volume was comparable between photon and proton plans. CONCLUSIONS: The dose to whole heart was relatively low in this study of @entity1 treated under conditions of DIBH. However, proton beam radiation was associated with lower minimum, maximum, and dose to 0.2 cm(3) of the LAD, which is the critical structure for late radiation therapy effects, compared to even the most optimized photon beam plan with DIBH and IMRT.

title: Proton beam versus photon beam dose to the heart and left anterior descending artery for left-sided XXXX .

answer: @entity0


abstract: Iloprost is a synthetic stable analogue of prostacyclin (PGI2), which shares its antiaggregating and vasodilating properties. Iloprost has been administered by i.v. route to @entity0 with @entity17 ( @entity17 ) of different origin (maximal dosage: 2 ng/kg/min 6 hours/day infusion for 14-28 days). In @entity0 with claudicatio intermittens (Fontaine stage II) iloprost improved the time to @entity11 and the maximal walking distance on treadmill, with an effect still lasting 60 days after suspension. This benefit was not related to a significant improvement in blood flow. Five multicentric, perspective, randomized versus placebo studies in @entity0 with more severe @entity17 (Fontaine stage III-IV) susceptible to surgical treatment, showed that iloprost was able to reduce @entity4 and @entity13 dimensions. Furthermore, tha amputation rate of the @entity2 limb was significantly lower in @entity0 treated with iloprost during a 6 month follow-up (p < 0.01). Iloprost was also more effective than @entity3 in causing @entity4 relief and @entity13 in @entity0 with @entity15 and more effective than @entity10 in reducing frequency, intensity and duration of @entity2 episodes in @entity0 with @entity16 . Minor side effects of iloprost administration are represented by facial @entity14 , @entity9 , @entity1 , @entity6 , @entity7 , abdominal cramping, @entity5 , whose frequency ranges from 16% to 70%; major collateral effects, occurring in less than 5% of @entity0 , are above all represented by severe @entity8 and @entity12 . Clinical data indicate therefore that iloprost treatment can allow to improve the clinical conditions and the prognosis in @entity0 with critical @entity2 of the limbs, not candidate to surgical revascularization, by causing a relief of @entity4 , a reduction in @entity13 dimensions and deferring amputation.

title: [The role of iloprost in the treatment of critical XXXX of the limbs].

answer: @entity2


abstract: BACKGROUND: Endothelial dysfunction, characterized by diminished endothelial progenitor cell (EPC) function and @entity4 ( @entity4 ), is a clinically significant feature of @entity5 ( @entity5 ). Mesenchymal stem cells (MSCs), which have pro-angiogenic properties, have the potential to restore endothelial function. Accordingly, we tested the hypothesis that MSCs increase EPC function and restore @entity4 ( @entity4 ). METHODS: Idiopathic dilated and @entity2 @entity0 were randomly assigned to receive autologous (n  =  7) or allogeneic (n  =  15) MSCs. We assessed EPC-colony forming units (EPC-CFUs), @entity4 , and circulating levels of @entity1 ( @entity1 ) in @entity0 before and three months after MSC transendocardial injection (n  =  22) and in healthy controls (n  =  10). FINDINGS: EPC-colony forming units (CFUs) were markedly reduced in @entity5 compared to healthy controls (4      3 vs. 25      16  CFUs, P  <  0.0001). Similarly, @entity4 % was impaired in @entity5 (5.6      3.2% vs. 9.0      3.3%, P  =  0.01). Allogeneic, but not autologous, MSCs improved endothelial function three months after treatment (  10      5 vs.   1      3  CFUs, P  =  0.0067;   3.7      3% vs.   -0.46      3% @entity4 , P  =  0.005). @entity0 who received allogeneic MSCs had a reduction in serum @entity1 levels three months after treatment, while @entity0 who received autologous MSCs had an increase (P  =  0.0012), and these changes correlated with the change in EPC-CFUs (P  <  0.0001). Lastly, @entity0 umbilical vein endothelial cells (HUVECs) with impaired vasculogenesis due to pharmacologic @entity6 synthase inhibition, were rescued by allogeneic MSC conditioned medium (P  =  0.006). INTERPRETATION: These findings reveal a novel mechanism whereby allogeneic, but not autologous, MSC administration results in the proliferation of functional EPCs and improvement in vascular reactivity, which in turn restores endothelial function towards normal in @entity0 with @entity5 . These findings have significant clinical and biological implications for the use of MSCs in @entity5 and other disorders associated with @entity3 .

title: Allogeneic Mesenchymal Stem Cells Restore Endothelial Function in XXXX by Stimulating Endothelial Progenitor Cells.

answer: @entity5


abstract: BACKGROUND/AIM: The modification of implant surfaces could affect mechanical implant stability as well as dynamics and quality of peri-implant bone healing. The aim of this 3-month experimental study in @entity0 was to investigate implant stability, marginal bone levels and bone tissue response to @entity4 dental implants with two laser-micro-grooved intraosseous surfaces in comparison with nongrooved sandblasted zirconia and sandblasted, high-temperature etched @entity2 implants. METHODS: Implant surface characterization was performed using optical interferometric profilometty and energy dispersive X-ray spectroscopy. A total of 96 implants (4 mm in diameter and 10 mm in length) were inserted randomly in both sides of the lower jaw of 12 Fox Hound @entity0 divided into groups of 24 each: the control ( @entity2 ), the group A (sandblasted zirconia), the group B (sandolasted zirconia plus microgrooved neck) and the group C (sandblasted zirconia plus all microgrooved). All the implants were immediately loaded. Insertion torque, periotest values, radiographic crestal bone level and removal torque were recorded during the 3-month follow-up. Qualitative @entity3 ( @entity3 ) analysis of the bone-implant interfaces of each group was performed. RESULTS: Insertion torque values were higher in the group C and control implants (p < 0.05). Periotest values increased in all the periods in proportion to the extent of microgrooving as follows: the group C > the control > the group B > the group A (p < 0.05). Radiographic measurements showed minimal @entity1 at 3 months for microgrooved zirconia implants (groups C and B) and control implants compared with the group A implants (p < 0.05). The removal torque values increased with time for all the groups as follows: the group C > the control > the group B > the group A (p < 0.05). @entity3 showed that implant surfaces of the groups B and C had an extra bone growth inside the microgrooves that corresponded to the shape and direction of the microgrooves. CONCLUSION: The addition of microgrooves to the entire intraosseous surface of zirconia dental implants enhances primary and secondary implant stability, promotes bone tissue ingrowth and preserves crestal bone levels.

title: Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on XXXX .

answer: @entity0


abstract: The projections of galanin (GAL)- and vasoactive intestinal peptide ( @entity2 )-immunoreactive (IR) and @entity0 synthase (NOS)-containing neurons in the small and large intestines of the amphibian Bufo marinus were investigated by their reactions to surgical interruption (myotomy). In the small intestine, myotomy caused accumulation of GAL- and @entity2 -IR and of @entity1 diaphorase reaction product (revealing NOS) in cut axons on the oral side of the operation site. On the anal side there was loss of GAL-IR axons from the circular muscle and myenteric plexus and long, anally directed processes could be traced from GAL-IR nerve cell bodies. There was no significant loss of @entity2 -IR or @entity1 diaphorase from nerve fibres in the myenteric plexus or circular muscle layer, although anally-directed axons could be traced from nerve cell bodies on the anal side of the operation sites. In the large intestine, myotomy caused accumulation of @entity2 -IR and of @entity1 diaphorase reaction product in cut axons on the oral side of the operation site. Anal to the cut, although there was no significant loss of these fibres from the muscle or myenteric plexus, anally directed axons could be traced from nerve cell bodies. GAL-IR fibres in the large intestine are of two types: a few contain GAL-IR alone and are thought to arise from enteric neurons; many contain both GAL- and SOM-IR and are thought to arise from nerve cell bodies in the hindgut. Myotomy caused an accumulation of GAL/SOM-IR material in fibres on the anal side of the cut and a substantial decrease in the number of fibres on the oral side. There was no detectable effect of myotomy on the GAL-IR fibres, although an abnormally high density of GAL-IR nerve cell bodies was found oral to the cut. These results indicate that @entity2 -IR and NOS-containing enteric neurons project in an oral to anal direction in the toad small and large intestines. Some of the neurons have short anal projections to the circular muscle. GAL-IR enteric neurons have similar projections in the small intestine, but their projections could not be determined in the large intestine. @entity3 /SOM-IR axons in the large intestine project from anal to oral. Myotomy in the large intestine appears to induce an increased or de novo expression of GAL-IR in enteric neurons oral to the cut.

title: Projections of XXXX synthase- and peptide-containing neurons in the small and large intestines of the toad (Bufo marinus).

answer: @entity0


abstract: BACKGROUND: @entity1 ( @entity1 ) can frequently and significantly affect morbidity and mortality of liver transplant (LT) recipients. AIMS: We analysed incidence, risk factors, outcome and impact of the immunosuppressive therapy on NC development after LT. METHODS: We analyzed 478 LT in 440 @entity0 , 93 (19.5%) were followed by @entity1 . RESULTS: The average LOS was longer in @entity0 experiencing @entity1 . The 1-, 3- and 5-year graft and @entity0 survival was similar in @entity0 with or without a NC. Multivariate analysis showed the following as independent risk factors for NC: a MELD-score>= 20 (OR=1.934 CI=1.186-3.153) and an immunosuppressive regimen based on calcineurin inhibitors (CNIs) (OR=1.669 CI=1.009-2.760). Among @entity0 receiving an @entity2 -based immunosuppression the 7.1% developed @entity1 , versus the 16.9% in those receiving a CNI(p=0.039). There was a 1-, 3- and 5-year NC-free survival of 81.7%, 81.1% and 77.7% in @entity0 receiving a CNI-based regimen and 95.1%, 93.6% and 92.7% in those not receiving a CNI-based regimen (p<0.001). CONCLUSIONS: In @entity0 undergoing a LT and presenting with non-modifiable risk factors for developing @entity1 an immunosuppressive regimen based on CNIs is likely to result in a higher rate of @entity1 compared to @entity3 inhibitors. This article is protected by copyright. All rights reserved.

title: XXXX after liver transplantation as a consequence of immunosuppression: univariate and multivariate analysis of risk factors.

answer: @entity1


abstract: BACKGROUND: @entity7 accounts for a large proportion of cardiovascular system associated morbidity and mortality. We studied the possible association between the histopathological changes of the @entity5 and the risk of @entity9 ( @entity9 ) using autopsy cases. METHODS: We performed an autopsy analysis (n   =   13, 4 @entity0 , 9 @entity0 mean age 67.5 years; age range 56-93 years) of @entity9 which occurred in @entity0 aged over 50 years during March 2010 to December 2013. The following variables were considered: sex, age, medical history, autopsy findings to macroscopic and histological evaluation of the heart. The autopsies were performed according to standard techniques. In all subjects, the heart was dissected following standard autopsy protocol and a 5 cm section of the right coronary artery (RCA) in the atrio-ventricular groove from its origin, a 5 cm segment of the left anterior descending artery (LADA) distal to the origin of the circumflex artery, but including the region of origin of the circumflex branch and left coronary artery (LCA) from its origin till the circumflex branch were excised, dissected out, fixed in 10  % @entity4 , marked for identification and sent for histopathological analysis. RESULTS: @entity7 were identified in 6.5  % of specimens, 69.34  % of males and 30.66  % of female. Such plaques were typically concentric and more represented with @entity1 , @entity6 , @entity3 crystals, and giant cells, as well as had a higher inflammatory cell count. Furthermore, intima and media thickness of coronary arteries were significantly higher in studied specimens with visualize the connective tissue layers of the adventitia and the @entity8 containing adipose cells in the periadventitial tissue. Furthermore, the degree of @entity2 of @entity7 increased proportionally with the increase in the intensity of lipid deposition and with the percentage of collagen in the @entity7 . CONCLUSION: In this study, age estimate to be a risk factor for @entity5 in individuals more than 50 years old and may be used to predict @entity9 . Altogether, an enhanced understanding of the pathobiologic processes responsible for @entity7 changes might allow for early identification of a high-risk coronary plaque and thereby provide a rationale for innovative diagnostic and/or therapeutic strategies for the management of coronary @entity0 and prevention of @entity10 .

title: A histopathological analysis of the epidemiology of XXXX : an autopsy study.

answer: @entity5


abstract: We evaluated the effects of mediators that can be produced by smooth muscle and endothelial cells on growth responses in isolated arteries. Segments of carotid and renal arteries, denuded of endothelium, were isolated from adult @entity0 and studied during tissue culture in the presence of @entity8 . Three days of culture in the presence of serum stimulated DNA synthesis in the media. During long-term culture new layers of cells developed at the borders of the arterial segments. Medial DNA synthesis depended less on serum than extramedial cell proliferation. During moderate stimulation, @entity2 and @entity5 enhanced and interleukin-1 and transforming growth factor-beta reduced medial DNA synthesis, whereas @entity6 , platelet-derived growth factor AA, platelet-derived growth factor BB, and @entity4 were without effect. Of these factors, only @entity5 stimulated extramedial cell proliferation. In addition, serum-stimulated but not @entity2 -stimulated medial DNA synthesis was less marked in arteries that had not been denuded of endothelium than in ee-endothelialized arteries. Differences between preparations with and without endothelium persisted in the absence of @entity1 and in the presence of an inhibitor of @entity3 synthase. These observations confirmed that DNA synthesis in the arterial media and extramedial cell proliferation are influenced by different factors. They further indicated that endothelial modulation of medial DNA synthesis does not seem to involved endothelium-derived @entity7 , @entity3 , or interleukin-1 and that it can be blunted by @entity2 .

title: Effects of candidate autocrine and paracrine mediators on growth responses in isolated XXXX arteries.

answer: @entity0


abstract: AIMS: To determine the frontal plane position of the ground reaction force vector at its centre of pressure under the hoof of walking @entity1 , and its projection through the distal limb joints, and to relate this to hoof geometric measurements. METHODS: Reflective markers were glued to the forelimb hooves and skin of 26 @entity1 , over palpable landmarks representing centres of the coffin, fetlock and @entity2 , and the dorsal toe at its most distal point. A 4-camera kinematic system recorded the position of these markers as the @entity1 walked in hand across a force platform, to generate a frontal plane representation of the ground reaction force vector passing between the markers at the joints. The position of the vector was calculated as the relative distance between the lateral (0%) and medial (100%) markers at each joint. @entity4 were taken of the hoof in frontal and sagittal views to determine hoof geometric measurements. Associations between these and the position of the force vector at each joint were examined using Pearson correlation coefficients. RESULTS: Mean vector position for both forelimbs at the toe, coffin, fetlock and carpal joint was 50.1 (SD 8.9), 53.0 (SD 9.2), 54.6 (SD 11.4) and 50.5 (SD17.3)%, respectively, of the distance between the lateral and medial sides of the joint in the frontal plane. Across all four joints, the vector position was slightly more medial (2-4%) for the right than left limb (p>0.05). Medial hoof wall angle was correlated (p<0.05) with force vector position at the fetlock (r=-0.402) and carpal (r=-0.317) joints; lateral hoof wall angle with vector position at the toe (r=0.288) and carpal (r=-0.34) joint, and medial hoof wall height with vector position at the fetlock (r=-0.306) and carpal (r=-0.303) joints. CONCLUSION: The position of the two-dimensional frontal plane ground reaction force vector at the toe, and at the fetlock and @entity2 was associated with hoof shape. Mediolateral hoof balance has been shown in vitro to affect articular forces, which may be a factor in development of @entity2 . The effect of hoof shape needs to be evaluated at @entity3 to determine the potential for @entity0 in the presence of larger forces.

title: Associations between hoof shape and the position of the frontal plane ground reaction force vector in walking XXXX .

answer: @entity1


abstract: Choline is a water-soluble nutrient essential for @entity0 life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which upon absorption by the host is converted in the liver to @entity3 ( @entity3 ). Recent studies revealed that @entity3 exacerbates @entity5 in @entity1 and positively correlates with the severity of this disease in @entity0 . However, which microbes contribute to TMA production in the @entity0 gut, the extent to which host factors (e.g., genotype) and diet affect TMA production and colonization of these microbes, and the effects TMA-producing microbes have on the bioavailability of dietary choline remain largely unknown. We screened a collection of 79 sequenced @entity0 intestinal isolates encompassing the major phyla found in the @entity0 gut and identified nine strains capable of producing TMA from choline in vitro. Gnotobiotic @entity1 studies showed that @entity3 accumulates in the serum of animals colonized with TMA-producing species, but not in the serum of animals colonized with intestinal isolates that do not generate TMA from choline in vitro. Remarkably, low levels of colonization by TMA-producing bacteria significantly reduced choline levels available to the host. This effect was more pronounced as the abundance of TMA-producing bacteria increased. Our findings provide a framework for designing strategies aimed at changing the representation or activity of TMA-producing bacteria in the @entity0 gut and suggest that the TMA-producing status of the gut microbiota should be considered when making recommendations about choline intake requirements for @entity0 . IMPORTANCE: @entity2 ( @entity2 ) is the leading cause of @entity4 and disability worldwide, and increased @entity3 ( @entity3 ) levels have been causally linked with @entity2 development. This work identifies members of the @entity0 gut microbiota responsible for both the accumulation of trimethylamine (TMA), the precursor of the proatherogenic compound @entity3 , and subsequent decreased choline bioavailability to the host. Understanding how to manipulate the representation and function of choline-consuming, TMA-producing species in the intestinal microbiota could potentially lead to novel means for preventing or treating @entity5 and choline @entity6 .

title: Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite XXXX .

answer: @entity3


abstract: The dynamic periphery of unstimulated, preaggregation, hunger-stage @entity2 amoebae was investigated by time-lapse videomicroscopy and digital image processing. Circular maps (i.e. of each of 360 radii around the cell transformed upon Cartesian coordinates) were constructed around the centroid of individual cell images and analysed in time series. This novel technique generated spatiotemporal structures of various degrees of order in the maps, which resemble classical wave interference patterns. The patterns thus demonstrate that cell movement is not random and that cells are intrinsically vibrating bodies, transited by self-organized, superpositioned, harmonic modes of @entity0 ( @entity0 ). These waves appear to depend upon spatiotemporal oscillations in the physicochemical reactions associated with actin polymerization, and they govern pseudopodial movements, cell shape and locomotion generally. @entity0 in this case are unrelated to the @entity1 -regulated oscillations, which characterize later, aggregative populations of @entity2 . However, the exposure of aggregation-stage cells to a pulse of the chemoattractant @entity1 induces a characteristic sequence of changes in the global cellular concentration and spatiotemporal distribution of fibrillar (F-)actin. This reaction begins with what appears to be a phase resetting of @entity0 and it may, therefore, underlie the cellular perception of and response to chemotactic signals. We also develop here an analytical mathematical description of @entity0 , and use it to simulate cell movements accurately.

title: The locomotion, shape and pseudopodial dynamics of unstimulated XXXX cells are not random.

answer: @entity2


abstract: OBJECTIVE: To investigate risk factors for @entity4 ( @entity4 ) in @entity0 with new-onset @entity2 ( @entity2 ). METHODS: We performed a nested case-control study of @entity0 with incident @entity2 included in the Epidemiological Investigation of @entity2 study. Cases with @entity4 were identified using Swedish national health registers and matched with up to 5 controls without @entity4 , based on incidence density-based sampling. Information on potential exposures (clinical disease activity, serologic features, genetic markers, comorbidities, pharmacotherapies, and sick leave) was collected from medical charts and register-based sources. RESULTS: We identified 138 cases and 624 controls. Smoking, history of @entity3 , and >50 days of sick leave the year following @entity2 onset were associated with an increased risk of @entity4 . Area under the curve measurements of C-reactive protein level, erythrocyte sedimentation rate, Disease Activity Score in 28 joints (DAS28), and global health in the upper tertile during the first year and the complete followup period were both strongly associated with an increased risk of @entity4 . Treatment with disease-modifying antirheumatic drugs did not alter the @entity4 risk, nor did the presence of rheumatoid factor (RF) or shared epitope alleles, whereas high anti-citrullinated protein antibody ( @entity5 ) levels were borderline significantly associated with @entity4 risk. CONCLUSION: In this study of risk factors for @entity4 in incident @entity2 , clinical markers of inflammatory activity, disease activity, and total number of days of sick leave and disability pension during the first year following @entity2 onset were identified as @entity4 risk factors. We found no association with RF, which was previously linked to @entity1 risk in @entity2 , but there was a borderline significant association with high @entity5 levels.

title: Risk factors for the rapid increase in risk of acute coronary events in @entity0 with new-onset XXXX : a nested case-control study.

answer: @entity2


abstract: OBJECTIVE: To investigate risk factors for @entity4 ( @entity4 ) in @entity0 with new-onset @entity2 ( @entity2 ). METHODS: We performed a nested case-control study of @entity0 with incident @entity2 included in the Epidemiological Investigation of @entity2 study. Cases with @entity4 were identified using Swedish national health registers and matched with up to 5 controls without @entity4 , based on incidence density-based sampling. Information on potential exposures (clinical disease activity, serologic features, genetic markers, comorbidities, pharmacotherapies, and sick leave) was collected from medical charts and register-based sources. RESULTS: We identified 138 cases and 624 controls. Smoking, history of @entity3 , and >50 days of sick leave the year following @entity2 onset were associated with an increased risk of @entity4 . Area under the curve measurements of C-reactive protein level, erythrocyte sedimentation rate, Disease Activity Score in 28 joints (DAS28), and global health in the upper tertile during the first year and the complete followup period were both strongly associated with an increased risk of @entity4 . Treatment with disease-modifying antirheumatic drugs did not alter the @entity4 risk, nor did the presence of rheumatoid factor (RF) or shared epitope alleles, whereas high anti-citrullinated protein antibody ( @entity5 ) levels were borderline significantly associated with @entity4 risk. CONCLUSION: In this study of risk factors for @entity4 in incident @entity2 , clinical markers of inflammatory activity, disease activity, and total number of days of sick leave and disability pension during the first year following @entity2 onset were identified as @entity4 risk factors. We found no association with RF, which was previously linked to @entity1 risk in @entity2 , but there was a borderline significant association with high @entity5 levels.

title: Risk factors for the rapid increase in risk of acute coronary events in XXXX with new-onset @entity2 : a nested case-control study.

answer: @entity0


abstract: BACKGROUND: @entity0 -reported outcome measures are an important component of the evidence for health technology appraisal. Their incorporation into cost-effectiveness analyses (CEAs) requires conversion of descriptive information into utilities. This can be done by using bespoke utility algorithms. Otherwise, investigators will often estimate indirect utility models for the @entity0 -reported outcome measures using off-the-shelf utility data such as the EQ-5D or SF-6D. Numerous modeling strategies are reported; however, to date, there has been limited utilization of Bayesian methods in this context. In this article, we examine the relative advantage of the Bayesian methods in relation to dealing with missing data, relaxing the assumption of equal variances and characterizing the uncertainty in the model predictions. METHODS: Data from a large @entity2 trial were used to examine the relationship between scores in each of the 19 domains of the European Organisation for Research and Treatment of @entity1 (EORTC) QLQ-C30/QLQ-MY20 and the EQ-5D utility. Data from 1839 @entity0 were divided 75%/25% between derivation and validation sets. A conventional ordinary least squares model assuming equal variance and a Bayesian model allowing unequal variance were estimated on complete cases. Two further models were estimated using conventional and Bayesian multiple imputation, respectively, using the full data set. Models were compared in terms of data fit, accuracy in model prediction, and characterization of uncertainty in model predictions. CONCLUSIONS: Mean EQ-5D utility weights can be estimated from the EORTC QLQ-C30/QLQ-MY20 for use in CEAs. Frequentist and Bayesian methods produced effectively identical models. However, the Bayesian models provide distributions describing the uncertainty surrounding the estimated utility values and are thus more suited informing analyses for probabilistic CEAs.

title: Use of Bayesian Markov Chain Monte Carlo Methods to Estimate EQ-5D Utility Scores from EORTC QLQ Data in XXXX for Use in Cost-Effectiveness Analysis.

answer: @entity2


abstract: Introduction. Although several intercalary reconstructions after resection of a lower extremity @entity4 are reported, there are no optimal methods which can provide a long-term reconstruction with fewest complications. We present the outcome of reconstruction using a devitalized autograft and a vascularized fibula graft composite. Materials and Methods. We conducted a retrospective review of 11 @entity0 (7 males, 4 females; median age 27 years) undergoing reconstruction using a devitalized autograft (pasteurization (n = 6), deep freezing (n = 5)) and a vascularized fibula graft composite for lower extremity malignant @entity4 (femur (n = 10), tibia (n = 1)). Results. The mean period required for callus formation and bone union was 4.4 months and 9.9 months, respectively. Four @entity2 occurred in 3 @entity0 : 2 @entity3 (1 pasteurized autograft, 1 frozen autograft) and 1 @entity1 and 1 implant failure (both in pasteurized autografts). Graft removal was required in 2 @entity0 with @entity3 . The mean MSTS score was 81% at last follow-up. Conclusions. Although some complications were noted in early cases involving a pasteurized autograft, our novel method involving a combination of a frozen autograft with a vascularized fibula graft and rigid fixation with a locking plate may offer better outcomes than previously reported allografts or devitalized autografts.

title: Intercalary reconstruction after wide resection of malignant XXXX of the lower extremity using a composite graft with a devitalized autograft and a vascularized fibula.

answer: @entity4


abstract: One characteristic neuropathological feature of @entity3 ( @entity3 ) is profound @entity5 in the nucleus basalis of Meynert, the major source of cholinergic innervation of the cerebral cortex. Clinically, anticholinergic activity causes a decline in cognitive function and increases the risk of @entity4 , thus possibly enhancing @entity3 pathologies and @entity2 . Until now there has been insufficient @entity0 neuropathological data to support this conclusion. Experimental studies using a @entity7 @entity1 model demonstrated anticholinergics enhanced tau pathology and @entity2 corresponding to central anticholinergic activity. Additionally, @entity6 , a cholinesterase inhibitor, ameliorated tau pathology and @entity2 in the same @entity1 model. These results indicate the balance between cholinergic and anticholinergic activities might affect @entity2 . Importantly, @entity2 observed in the @entity1 model seemed to correspond to the distribution of microglial activation, and it was reported that neuroinflammation plays an important role in the pathomechanism of @entity3 , while anticholinergic activity augments inflammatory responses. Moreover, some studies indicated b-amyloid itself depletes cholinergic function similarly to anticholinergic activity. Thus, anticholinergic activity might initiate and/or accelerate @entity3 pathology. Limited @entity0 data support the conclusion that anticholinergic activity enhances @entity3 -related neuropathology and @entity2 . However, experimental data from a @entity7 @entity1 model indicated anticholinergic activity might enhance @entity2 with enhanced neuroinflammation including microglial activation.

title: Does Anticholinergic Activity Affect Neuropathology? Implication of Neuroinflammation in XXXX .

answer: @entity3


abstract: Adult adipose tissue-derived stem cells (ADSCs) were found to hold great promise for use in bone tissue repair and regeneration. The present study aims to improve the osteogenesis of ADSCs by Superparamagnetic @entity2 (SPIO), which is widely used in tissue imaging. In this study, adipose-derived stem cells were harvested from 4-week-old male Sprague-Dawley (SD) @entity0 . The proliferation rates of ADSCs labeling with or without SPIO were assessed by using @entity3 assay. The osteogenic capability was examined by employing the @entity4 activity detection kit. The mineralization of cells was determined by staining with Alizarin red S. Flow cytometry analysis was used to examine the cell apoptosis treated with or without SPIO. Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis was utilized to detect the @entity5 , Opn, Ocn and @entity4 genes in the cells. The results indicated that SPIO could promote @entity0 ADSCs proliferation and reduce @entity0 ADSCs apoptosis. Also, SPIO could significantly enhance the @entity4 and @entity1 staining of ADSCs in -SPIO group and +SPIO group (P < 0.01). Furthermore, we also found that the expression of @entity5 , Opn, Ocn and @entity4 was significantly increased after SPIO treatment compared to the un-treated cells (P < 0.01). In conclusion, SPIO could promote the osteogenic differentiation of @entity0 adipose-derived stem cells, which would also become a great potential therapeutic tool in bone tissue engineering.

title: Superparamagnetic XXXX promotes osteogenic differentiation of @entity0 adipose-derived stem cells.

answer: @entity2


abstract: Adult adipose tissue-derived stem cells (ADSCs) were found to hold great promise for use in bone tissue repair and regeneration. The present study aims to improve the osteogenesis of ADSCs by Superparamagnetic @entity2 (SPIO), which is widely used in tissue imaging. In this study, adipose-derived stem cells were harvested from 4-week-old male Sprague-Dawley (SD) @entity0 . The proliferation rates of ADSCs labeling with or without SPIO were assessed by using @entity3 assay. The osteogenic capability was examined by employing the @entity4 activity detection kit. The mineralization of cells was determined by staining with Alizarin red S. Flow cytometry analysis was used to examine the cell apoptosis treated with or without SPIO. Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis was utilized to detect the @entity5 , Opn, Ocn and @entity4 genes in the cells. The results indicated that SPIO could promote @entity0 ADSCs proliferation and reduce @entity0 ADSCs apoptosis. Also, SPIO could significantly enhance the @entity4 and @entity1 staining of ADSCs in -SPIO group and +SPIO group (P < 0.01). Furthermore, we also found that the expression of @entity5 , Opn, Ocn and @entity4 was significantly increased after SPIO treatment compared to the un-treated cells (P < 0.01). In conclusion, SPIO could promote the osteogenic differentiation of @entity0 adipose-derived stem cells, which would also become a great potential therapeutic tool in bone tissue engineering.

title: Superparamagnetic @entity2 promotes osteogenic differentiation of XXXX adipose-derived stem cells.

answer: @entity0


abstract: UNASSIGNED: @entity3 ( @entity3 ) @entity0 with @entity1 ( @entity1 ) have variable clinical courses and therapeutic outcomes. Survival time after diagnosis of @entity1 may be several months to years. Long-term follow-up is necessary to determine prognostic factors for survival in @entity3 with @entity1 . The purpose of this study was to investigate the clinical features and therapeutic outcomes of @entity3 with @entity1 after 10 years of follow-up. The study population consisted of 70 @entity0 who underwent initial thyroidectomy before 2004 and had @entity1 beyond the locoregional neck area. Of these 70 @entity0 , 40 @entity0 were diagnosed with @entity1 before or within 9 months after initial thyroidectomy in first radioactive iodide (I) whole-body scintigraphy (group A), and 30 @entity0 were diagnosed with @entity1 during the follow-up period (group B). @entity0 with @entity1 underwent 3.7 to 7.4 GBq I therapy every 6 to 12 months. After a mean follow-up period of 10.1  0.9 years, the disease-specific mortality and remission rates were 70.0% (49/70) and 10% (7/70), respectively. The survival rates for @entity0 in groups A and B were 72.5% and 96.7% at 1 year, 47.5% and 90.0% at 5 years, 40.0% and 70.0% at 10 years, 36.4% and 41.1% at 15 years, and 35.0% and 8.0% at 20 years, respectively. The percentage of male and older @entity0 and @entity0 with larger @entity2 size was higher in the mortality group than in the survival group, whereas the percentage of @entity0 with I avid metastatic lesions (first @entity1 ) was lower in the mortality group. The percentage of @entity0 with secondary primary @entity2 was higher in group B than in group A. In the multiple regression analysis, age and male gender were independently associated with disease-specific mortality. In conclusion, after a mean follow-up of 10.1 years, the disease-specific mortality rate for @entity3 with @entity1 was 70.0%. Older @entity0 and male @entity3 @entity0 with @entity1 need more aggressive treatment. The timing of @entity1 diagnosis did not influence disease-specific mortality.

title: Long-Term Follow-Up of the Therapeutic Outcomes for @entity3 With Distant XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity3 ( @entity3 ) @entity0 with @entity1 ( @entity1 ) have variable clinical courses and therapeutic outcomes. Survival time after diagnosis of @entity1 may be several months to years. Long-term follow-up is necessary to determine prognostic factors for survival in @entity3 with @entity1 . The purpose of this study was to investigate the clinical features and therapeutic outcomes of @entity3 with @entity1 after 10 years of follow-up. The study population consisted of 70 @entity0 who underwent initial thyroidectomy before 2004 and had @entity1 beyond the locoregional neck area. Of these 70 @entity0 , 40 @entity0 were diagnosed with @entity1 before or within 9 months after initial thyroidectomy in first radioactive iodide (I) whole-body scintigraphy (group A), and 30 @entity0 were diagnosed with @entity1 during the follow-up period (group B). @entity0 with @entity1 underwent 3.7 to 7.4 GBq I therapy every 6 to 12 months. After a mean follow-up period of 10.1  0.9 years, the disease-specific mortality and remission rates were 70.0% (49/70) and 10% (7/70), respectively. The survival rates for @entity0 in groups A and B were 72.5% and 96.7% at 1 year, 47.5% and 90.0% at 5 years, 40.0% and 70.0% at 10 years, 36.4% and 41.1% at 15 years, and 35.0% and 8.0% at 20 years, respectively. The percentage of male and older @entity0 and @entity0 with larger @entity2 size was higher in the mortality group than in the survival group, whereas the percentage of @entity0 with I avid metastatic lesions (first @entity1 ) was lower in the mortality group. The percentage of @entity0 with secondary primary @entity2 was higher in group B than in group A. In the multiple regression analysis, age and male gender were independently associated with disease-specific mortality. In conclusion, after a mean follow-up of 10.1 years, the disease-specific mortality rate for @entity3 with @entity1 was 70.0%. Older @entity0 and male @entity3 @entity0 with @entity1 need more aggressive treatment. The timing of @entity1 diagnosis did not influence disease-specific mortality.

title: Long-Term Follow-Up of the Therapeutic Outcomes for XXXX With Distant @entity1 .

answer: @entity3


abstract: BACKGROUND: The aim of this study was to clarify the distinctions in the clinical characteristics and outcomes between early- and late-onset severe @entity1 after renal transplantation requiring ICU admission. METHODS: The data were retrospectively collected in consecutive renal recipients with severe @entity1 from January 1, 2009, to December 31, 2013, in a tertiary ICU. We classified the @entity0 according to the time of @entity1 onset as follows: early-onset severe @entity1 (E-SP) corresponded to a @entity2 occurring during the first year following the transplantation, and late-onset severe @entity1 (L-SP) corresponded to a @entity2 occurring after the first year following the transplantation. RESULTS: In the E-SP @entity0 , fungi (42.1%) and viruses (31.6%) were the most common pathogens. Twenty-three (71.9%) @entity0 received non-invasive ventilation (NIV), 15 (65.2%) of whom were intubated. The median duration of the ICU and hospital stays was 11    5 and 19    4 days, respectively. In the L-SP @entity0 , bacteria (42.1%) and viruses (26.3%) were the predominant pathogens. Four of 15 (26.7%) @entity0 failed NIV treatment. The median duration of the ICU and hospital stays was 9    3 and 16    3 days, respectively. The ICU mortality among the E-SP @entity0 was 18.8% (6 of 32), compared with 7.1% (2 of 28) in the L-SP group (P = 0.264). CONCLUSIONS: Early-onset severe @entity1 in renal transplant recipients resulted in a more serious condition, higher rate of NIV failure, longer duration of mechanical ventilation, and increased length of ICU and hospital stays.

title: Early- and late-onset severe XXXX after renal transplantation.

answer: @entity1


abstract: UNASSIGNED: Purpose To investigate the efficacy and safety of conventional transarterial chemoembolization (TACE) (cTACE) in combination with bevacizumab or a placebo in @entity0 with @entity4 ( @entity4 ) in a randomized controlled double-blind phase II trial. Materials and Methods This study was approved by the institutional review board, and written informed consent was obtained prior to inclusion. A total of 40 @entity0 (20 @entity0 per group, all 18 years or older) with histologically confirmed early- or intermediate-stage @entity4 and @entity0 -Pugh class A or B @entity2 were scheduled for inclusion. The primary endpoint was radiologic progression at 12 months according to European Association for the Study of the Liver criteria. Secondary endpoints were safety and @entity7 ( @entity7 ). @entity0 underwent cTACE with @entity6 and intravenous administration of a placebo (cTACE-C) or bevacizumab (cTACE-B) (5 mg per kilogram of body weight) every 2 weeks for 52 weeks. After the first TACE procedure, TACE was repeated twice in 4-week intervals if indicated and technically feasible and on demand thereafter. Statistical analyses were performed with statistical software. P < .05 indicated a significant difference. Results Thirty-two @entity0 were recruited between January 2006 and December 2009 (29 male, three female; mean age, 61 years    8 [standard deviation]; Barcelona Clinic @entity3 stage A, n = 4; Barcelona Clinic @entity3 stage B, n = 28; predominant cause, @entity5 [n = 15]; @entity0 -Pugh class A disease, n = 22; @entity0 -Pugh class B disease, n = 10; 16 @entity0 received bevacizumab; 16 @entity0 received a placebo). @entity0 underwent a median of three TACE cycles and received 13 infusions of bevacizumab versus 11 infusions of the placebo before the trial was stopped prematurely for safety reasons. Severe (grade 3-5) septic (n = 8 vs n = 3) and vascular (n = 9 vs n = 0) side effects were observed almost exclusively in the cTACE-B group. Median survival was worse in the cTACE-B group than in the cTACE-C group (5.3 vs 13.7 months; hazard ratio [HR], 1.7; 95% confidence interval [CI]: 0.8, 3.6; P = .195) and reached significance in @entity0 with @entity0 -Pugh class A @entity2 (7.3 vs 26.5 months; HR, 2.6; 95% CI: 1.0, 6.6; P = .049). The primary endpoint was not met, since there was no difference in radiologic response between the groups at 3, 6, or 12 months. Conclusion No improvement in radiologic @entity1 response or @entity7 was observed in @entity0 with @entity4 who received cTACE and bevacizumab, but severe and even lethal septic and vascular side effects occurred. Thus, bevacizumab cannot be recommended as an adjuvant treatment to cTACE. (  ) RSNA, 2015 Online supplemental material is available for this article.

title: XXXX : A Phase II Randomized Controlled Double-Blind Trial of Transarterial Chemoembolization in Combination with Biweekly Intravenous Administration of Bevacizumab or a Placebo.

answer: @entity4


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a common procedure in adults with @entity3 ( @entity3 ). Implantable dual lumen Vortex (DLV) ports can be used for @entity4 in @entity0 with poor peripheral venous access. We performed a retrospective cohort study of @entity4 procedures performed in adults with @entity3 . The main objective of the study was to compare the inlet speed, duration of procedures and rate of complications performed through DLV ports to those performed through temporary central venous and peripheral catheters. Twenty-nine adults with @entity3 underwent a total of 318 @entity4 procedures. Twenty adults had DLV ports placed and 218 procedures were performed using DLV ports. Mean length of follow-up after DLV port placement was 397        263 days. Six DLV ports were removed due to infection and 1 for malfunction after a mean of 171        120 days. Compared to temporary central venous and peripheral catheters, DLV port procedures had a greater rate of procedural complications, a longer duration, and a lower inlet speed (all P   <   0.01). When accounting for the maximum allowable inlet speed to avoid @entity2 @entity1 , 40% of DLV port procedures were greater than 10% below maximum speed, compared to 7 and 14% of procedures performed through temporary central venous and peripheral catheters (P   <   0.0001). In conclusion, DLV ports can be used for @entity4 in adults with @entity3 , albeit with more procedural complications and longer duration. The smaller internal diameter and longer catheter of DLV ports compared to temporary central venous catheters likely accounts for the differences noted. J. Clin. Apheresis, 2015.    2015 Wiley Periodicals, Inc.

title: Use of a dual lumen port for automated red cell exchange in adults with XXXX .

answer: @entity3


abstract: UNASSIGNED: Definitive endoderm (DE) is a vital precursor for internal organs such as liver and pancreas. Efficient protocol to differentiate @entity0 embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs) to DE is essential for regenerative medicine and for modeling diseases; yet, poor cell survival during DE differentiation remains unsolved. In this study, our use of @entity1 supplement in modified differentiation protocols has led to a substantial improvement. We used an @entity2 -enhanced green fluorescent protein (eGFP) reporter hESC line to compare and modify established DE differentiation protocols. Both total live cell numbers and the percentages of eGFP-positive cells were used to assess differentiation efficiency. Among tested protocols, three modified protocols with serum-free @entity1 supplement were developed to generate a high number of DE cells. Massive cell death was avoided during DE differentiation and the percentage of DE cells remained high. When the resulting DE cells were further differentiated toward the pancreatic lineage, the expression of pancreatic-specific markers was significantly increased. Similar high DE differentiation efficiency was observed in H1   hESCs and iPSCs through the modified protocols. In @entity1 components, bovine serum albumin was found to facilitate DE differentiation and cell survival. Using our modified DE differentiation protocols, satisfactory quantities of quality DE can be produced as primary material for further endoderm lineage differentiation.

title: Improvement of Cell Survival During XXXX Pluripotent Stem Cell Definitive Endoderm Differentiation.

answer: @entity0


abstract: BACKGROUND: Evidence is lacking to recommend one diet over another when treating @entity5 ( @entity5 ). OBJECTIVES: To obtain preliminary data, comparing the impact of a low-glycaemic load (LGL) vs. @entity3 ( @entity3 ) diet on biochemical hyperandrogenism in overweight and @entity1 adolescents with @entity5 . To ascertain feasibility of recruiting study @entity0 , in partnership with an adolescent clinic, and implementing dietary interventions. METHODS: Randomized controlled trial of 19 overweight and @entity1 adolescents with @entity5 and not using hormonal contraceptives (HCs). Interventions comprised nutrition education, dietary counselling and cooking workshops to foster adherence to a LGL (45% @entity4 , 35% fat, 20% protein) or @entity3 (55% @entity4 , 25% fat, 20% protein) diet over 6 months. Serum bioavailable @entity2 was the primary outcome. RESULTS: Sixteen (LGL, n   =   7; @entity3 , n   =   9) @entity0 completed the study. Body fat percentage decreased (P   <   0.05) in response to the interventions, with no difference between the LGL and @entity3 groups (-1.2% vs. -2.2%; P   =   0.16). Bioavailable @entity2 did not change for either group (-0.4 vs. -1.8   ng   dL(-1) ; P   =   0.35). Regarding feasibility, recruiting adolescents posed a challenge, and use of HCs was a main reason for ineligibility. @entity0 attended 5.9 of 6 in- @entity0 visits and 2.6 of 3 cooking workshops, completed 4.9 of 6 telephone counselling calls, and reported high satisfaction with the diets and cooking workshops (>= 8 on a 10-cm scale). CONCLUSIONS: Dietary interventions were beneficial for weight control but did not attenuate biochemical hyperandrogenism. Innovative strategies are needed to recruit adolescents for studies aimed at assessing independent effects of diet on features of @entity5 .

title: A randomized pilot study of dietary treatments for XXXX in adolescents.

answer: @entity5


abstract: BACKGROUND: A low @entity4 ( @entity5 )/ @entity2 (AA) ratio is known to be associated with cardiovascular events. However, the relationship between the @entity5 /AA ratio and coronary plaque vulnerability assessed by optical coherence tomography (OCT) has not been examined thoroughly. This study examined the relationship between the @entity5 /AA ratio and coronary plaque vulnerability assessed by OCT in @entity0 with @entity1 ( @entity1 ). METHODS: We evaluated 59 @entity1 @entity0 who had undergone percutaneous coronary intervention using OCT. We divided them into 2 groups according to OCT findings-those with and without thin-cap @entity3 (TCFA)-and compared the @entity5 /AA ratio between the groups. RESULTS: We identified 32 and 27 @entity0 with and without TCFA, respectively. The @entity5 /AA ratio was significantly lower in @entity0 with TCFA than in those without TCFA [0.35, interquartile range (0.21-0.44) vs. 0.54, interquartile range (0.42-0.70); p<0.001]. In multivariate logistic regression analysis, the @entity5 /AA ratio was an independent predictor of TCFA (odds ratio, 0.09; 95% confidence interval, 0.007-0.99; p=0.049). The @entity5 /AA ratio and fibrous cap thickness showed a significant positive correlation (Spearman   =0.46; p<0.001). Furthermore, receiver operating characteristic curve analysis showed that an @entity5 /AA ratio<0.46 could predict TCFA (81.3%, sensitivity; 74.1%, specificity). CONCLUSIONS: A low serum @entity5 /AA ratio is significantly associated with coronary plaque vulnerability assessed by OCT in @entity1 @entity0 .

title: Low XXXX to @entity2 ratio is associated with thin-cap @entity3 determined by optical coherence tomography.

answer: @entity4