abstract: The mechanism of macrophage activation was studied using three activating substances, @entity2 macrophage activation factor (MAF), lipopolysaccharide (LPS) and muramyl dipeptide ( @entity4 ). @entity2 peritoneal exudate macrophages were activated to exhibit the accelerated @entity1 consumption in response to these activating substances. Calmodulin-specific inhibitors, @entity3 and No. 233, inhibited macrophage activation with MAF and LPS, while these inhibitors did not affect the activation with @entity4 . @entity0 uptake into macrophages was enhanced in MAF-treated macrophages, but LPS and @entity4 did not affect the @entity0 uptake. @entity5 and @entity6 , inhibitors of transglutaminase-dependent protein internalization into cells and/or of lysosomal enzymes, effectively inhibited the activating effect of LPS, but not those of MAF and @entity4 . These results suggest that @entity0 and calmodulin play a role in macrophage activation with MAF, and neither transglutaminase-dependent internalization nor lysosomal enzymes participate in the activation process. In case of LPS, internalization into cells would be necessary for its activating effect. The processing of the contrary, since the activating effect of @entity4 was not affected by any of these inhibitors, the mechanism of activation with @entity4 remains obscure. Thus, the mechanisms of macrophage activation with MAF, LPS and @entity4 appear to be different from each other.

title: Different mechanisms of macrophage activation with XXXX macrophage activation factor, lipopolysaccharide and muramyl dipeptide.

answer: @entity2


abstract: The clinical, microbiologic, and cytologic features of the @entity1 model of @entity6 with enterobacteria, @entity4 were elucidated. @entity1 eyes were instilled with @entity4 and the eyes were studied by biomicroscopy, culture, cytology, pathology, and electron microscopy. All animals developed moderate to severe @entity3 that was present in 18% of the animals on day 1. It became more intense, appearing in all of the eyes on day 10 and disappeared before day 30. The cultures for @entity4 were almost all positive on days 1 and 2, declined steadily to 10% on day 10, and were negative after that. A coarse, @entity2 was present in more than 90% of the infected eyes at some time during the experiment. The @entity2 had a biphasic clinical course. The first peak correlated with the maximum culture results, but during the second peak only 10% of the cultures were positive. Electron microscopy of the @entity0 showed the @entity4 at the epithelial surface within surface epithelial cells during the early phases of infection. The later phase @entity2 , with negative culture results, resembles the @entity2 of @entity5 .

title: Experimental XXXX ocular infection by @entity4 .

answer: @entity1


abstract: The clinical, microbiologic, and cytologic features of the @entity1 model of @entity6 with enterobacteria, @entity4 were elucidated. @entity1 eyes were instilled with @entity4 and the eyes were studied by biomicroscopy, culture, cytology, pathology, and electron microscopy. All animals developed moderate to severe @entity3 that was present in 18% of the animals on day 1. It became more intense, appearing in all of the eyes on day 10 and disappeared before day 30. The cultures for @entity4 were almost all positive on days 1 and 2, declined steadily to 10% on day 10, and were negative after that. A coarse, @entity2 was present in more than 90% of the infected eyes at some time during the experiment. The @entity2 had a biphasic clinical course. The first peak correlated with the maximum culture results, but during the second peak only 10% of the cultures were positive. Electron microscopy of the @entity0 showed the @entity4 at the epithelial surface within surface epithelial cells during the early phases of infection. The later phase @entity2 , with negative culture results, resembles the @entity2 of @entity5 .

title: Experimental @entity1 ocular infection by XXXX .

answer: @entity4


abstract: BACKGROUND: @entity4 are a group of delayed-onset @entity4 induced by a @entity6 receptor blocking agent. There are several phenomenologically distinct types of @entity9 . REVIEW SUMMARY: The term @entity4 has been used to refer to the @entity9 that presents with rapid, repetitive, stereotypic movements mostly involving the oral, buccal, and lingual areas. @entity14 can be focal, segmental, or generalized. It commonly affects the face and neck followed by the arms and trunk. It usually results in retrocollis when it involves the neck and trunk arching backwards when it involves the trunk. Tardive @entity11 is characterized by a feeling of inner @entity11 and jitteriness with an inability to sit or stand still. Other @entity4 include @entity8 , @entity10 , @entity1 , and @entity13 . It remains unclear whether @entity3 truly exists. The only way to prevent @entity9 is to avoid its etiologic agents. Chronic use of @entity6 receptor blocking agents should be limited as much as possible to @entity0 with chronic @entity5 . In general, for mild @entity9 , reducing the neuroleptic dose, switching to an atypical agent, or discontinuing antipsychotic treatment altogether in the hope of facilitating remission is recommended. For moderate to severe @entity9 , @entity7 or @entity12 may be the most effective agent. Neuroleptics should be resumed to treat @entity15 in the absence of active @entity2 only as a last resort for persistent, disabling, and treatment-resistant @entity15 . CONCLUSIONS: The severity of the @entity9 and the absolute need for antipsychotic therapy often dictate the treatment approach for this disorder.

title: Classification and treatment of XXXX .

answer: @entity4


abstract: BACKGROUND: Estimates of excess risk of @entity3 among prior users of @entity4 and @entity5 have varied widely. Two major forms of bias appear to contribute to this variability and also result in a systematic under-estimation of risk. The first, a form of nondifferential misclassification, is the result of including background, prevalent cases among both exposed and unexposed @entity0 in calculations of risk. The second bias results from not considering the relatively short duration of exposure to drugs. METHODS: We examined data from all available echocardiographic studies reporting the prevalence of @entity1 ( @entity1 ) and @entity2 ( @entity2 ) among @entity0 exposed to @entity4 or @entity5 and a suitable control group. We also included one study in which previously existing @entity1 or @entity2 had been excluded. We corrected for background prevalent cases, estimated incidence rates in unexposed @entity0 , and performed a @entity0 -years analysis of apparent incidence rates based on exposure time to provide an unbiased estimate of relative risk. RESULTS: Appearance of new @entity1 was strongly related to duration of exposure (R2 = 0.75, p < 0.0001). The summary relative risk for mild or greater @entity1 was 19.6 (95% CI 16.3-23.5, p < 0.00001); for moderate or greater @entity2 it was 5.9 (95% CI 4.0-8.6, p < 0.00001). CONCLUSION: These findings provide strong support for the view that @entity4 and @entity5 are potent causal factors in the development of both aortic and mitral @entity3 .

title: Risk of XXXX associated with use of @entity4 .

answer: @entity3


abstract: BACKGROUND: Estimates of excess risk of @entity3 among prior users of @entity4 and @entity5 have varied widely. Two major forms of bias appear to contribute to this variability and also result in a systematic under-estimation of risk. The first, a form of nondifferential misclassification, is the result of including background, prevalent cases among both exposed and unexposed @entity0 in calculations of risk. The second bias results from not considering the relatively short duration of exposure to drugs. METHODS: We examined data from all available echocardiographic studies reporting the prevalence of @entity1 ( @entity1 ) and @entity2 ( @entity2 ) among @entity0 exposed to @entity4 or @entity5 and a suitable control group. We also included one study in which previously existing @entity1 or @entity2 had been excluded. We corrected for background prevalent cases, estimated incidence rates in unexposed @entity0 , and performed a @entity0 -years analysis of apparent incidence rates based on exposure time to provide an unbiased estimate of relative risk. RESULTS: Appearance of new @entity1 was strongly related to duration of exposure (R2 = 0.75, p < 0.0001). The summary relative risk for mild or greater @entity1 was 19.6 (95% CI 16.3-23.5, p < 0.00001); for moderate or greater @entity2 it was 5.9 (95% CI 4.0-8.6, p < 0.00001). CONCLUSION: These findings provide strong support for the view that @entity4 and @entity5 are potent causal factors in the development of both aortic and mitral @entity3 .

title: Risk of @entity3 associated with use of XXXX .

answer: @entity4


abstract: A case of spontaneous spinal extradural @entity5 was reported. The @entity0 , a 25-year-old housewife, was hospitalized with back @entity1 , followed by @entity4 of both legs and urinary disturbance during next 2 hours. A myelogram demonstrated that contrast medium was incompletely blocked at the level from the 3rd to the 4th thoracic spine by extradural mass. Unfortunately X-ray CT scan was not examined, however, a NMR-CT scan excluded disc protrusion and dissecting @entity2 of the aorta. Eight hours after onset, wide laminectomy was performed as emergency operation and an @entity6 located in the ventral side with compression of the thoracic cord was removed as completely as possible. She was discharged with excellent recovery after operation. The spontaneous @entity6 is rare emergency. The exact etiology is unknown, and no explanation is offered as to why the @entity5 is usually dorsal in location. To our knowledge, only three cases of @entity6 which located in the ventral side were reported. Considering from our experience and other reports, it seems to be the most important point to avoid the unnecessary pressure on the spinal cord and to search the exact @entity3 point in the operative procedure of @entity6 .

title: [Spontaneous extradural XXXX localized in the ventral side of the thoracic spinal cord--a case report].

answer: @entity5


abstract: The association between calcification of the coronary arteries and coronary artery narrowing is well established. However, fluoroscopic visualization of coronary calcifications has been insufficiently sensitive to be useful as a screening test. Since digitization of radiographic images permits the subtraction of noncardiac structures from moving cardiac structures, such subtraction might increase the sensitivity of coronary fluoroscopy. To determine whether coronary calcifications were better visualized with digital subtraction fluoroscopy than with conventional fluoroscopy, we taped diseased @entity0 coronary arteries to a pulsating water balloon inside the thorax of a @entity1 cadaver and studied this model with both fluoroscopic techniques. @entity4 were more easily identified with digital subtraction fluoroscopy than with conventional fluoroscopy. We tested the method clinically by submitting 191 subjects without history or electrocardiographic evidence of previous @entity3 who were referred for coronary arteriography to both fluoroscopic studies. For at least one, at least two, and three calcified coronary arteries, digital fluoroscopy was more sensitive (92%, 66%, and 40%) than conventional fluoroscopy (63%, 21%, and 2%) (all p less than .001) for the prediction of significant @entity2 (greater than 50%). Although digital fluoroscopy was less specific than conventional fluoroscopy (digital: 65%, 89%, and 97%; conventional: 81%, 98%, and 100%) (all but last, p less than .01), receiver operating curve analysis revealed a significantly larger area under the curve, indicating higher accuracy for the digital technique (p = .03). Digital subtraction fluoroscopy was more accurate in younger than in older @entity0 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Digital subtraction fluoroscopy: a new method of detecting coronary calcifications with improved sensitivity for the prediction of XXXX .

answer: @entity2


abstract: BACKGROUND: @entity7 is an uncommon @entity1 of unknown etiology involving the brachial plexus, which is manifest by shoulder and arm @entity4 , @entity6 , and sensory loss. Because of the diversity and variability of the initial features and similarity to other neurologic and @entity1 , @entity0 may initially present to internists, orthopedic surgeons, or pulmonologists, and may be initially diagnosed with an alternative disorder. REVIEW SUMMARY: @entity7 occurs at an annual incidence rate of 1 to 2 cases per 100,000 population. The disorder is most common in adulthood, but @entity0 of any age may be affected. @entity4 is the most common initial symptom and is followed by @entity6 in the distribution of a single nerve or diffuse regions of the brachial plexus. Although the exact etiology is unknown, many associated factors, such as immunizations, minor @entity2 , @entity5 , pregnancy, and surgical procedures have been associated with the development of the disorder. Evaluation with electrodiagnostic and radiographic studies is useful in confirming the diagnosis and excluding alternative disorders. No treatment has been definitively proven to improve the course of the disorder; however, the overall prognosis is good, with approximately 90% of @entity0 demonstrating significant improvement. CONCLUSIONS: @entity7 is an important, potentially debilitating disorder, which may present to physicians in multiple specialties. Awareness of this disorder may preclude unnecessary testing or surgical procedures and can guide toward appropriate treatment with physical therapy. Counseling @entity0 about the overall good prognosis can help appease @entity0 ' @entity3 about a more sinister diagnosis or course.

title: XXXX : clinical features and diagnostic evaluation.

answer: @entity7


abstract: In each of three components of a multiple schedule, monkeys were required to emit a different sequence of four responses in a predetermined order on four levers. Sequence completions produced food under a fixed-ratio schedule. Errors produced a brief timeout. One component of the multiple schedule was a repeated-acquisition task where the four-response sequence changed each session (learning). The second component of the multiple schedule was also a repeated-acquisition task, but acquisition was supported through the use of a stimulus fading procedure (faded learning). In a third component of the multiple schedule, the sequence of responses remained the same from session to session (performance). @entity2 , @entity0 , @entity4 and @entity3 each produced dose-related decreases in overall response rate. At high doses which produced equivalent rate-decreasing effects, @entity4 and @entity3 generally produced greater disruption of accuracy in the learning component than did @entity2 or @entity0 . @entity1 5.6 microgram/kg shifted to the right by approximately 1/2-log unit the @entity2 and @entity0 dose-effect curves, but produced little or no change in the @entity4 dose-effect curves. At 56 micrograms/kg @entity1 completely antagonized both the rate-decreasing and error-increasing effects of @entity2 and @entity0 . The same dose of @entity1 tended to produce greater antagonism of the effects of @entity4 on accuracy than on rate, which was shifted by only 1/4-log unit. In contrast, @entity1 failed to antagonize the effects of @entity3 on either rate or accuracy. Thus it would appear that while @entity4 and @entity3 produce similar disruptions in the accuracy of a discrimination, the effects of each are differentially sensitive to antagonism by @entity1 .

title: Effects of opioids and @entity3 in combination with XXXX on the acquisition and performance of response sequences in monkeys.

answer: @entity1


abstract: In each of three components of a multiple schedule, monkeys were required to emit a different sequence of four responses in a predetermined order on four levers. Sequence completions produced food under a fixed-ratio schedule. Errors produced a brief timeout. One component of the multiple schedule was a repeated-acquisition task where the four-response sequence changed each session (learning). The second component of the multiple schedule was also a repeated-acquisition task, but acquisition was supported through the use of a stimulus fading procedure (faded learning). In a third component of the multiple schedule, the sequence of responses remained the same from session to session (performance). @entity2 , @entity0 , @entity4 and @entity3 each produced dose-related decreases in overall response rate. At high doses which produced equivalent rate-decreasing effects, @entity4 and @entity3 generally produced greater disruption of accuracy in the learning component than did @entity2 or @entity0 . @entity1 5.6 microgram/kg shifted to the right by approximately 1/2-log unit the @entity2 and @entity0 dose-effect curves, but produced little or no change in the @entity4 dose-effect curves. At 56 micrograms/kg @entity1 completely antagonized both the rate-decreasing and error-increasing effects of @entity2 and @entity0 . The same dose of @entity1 tended to produce greater antagonism of the effects of @entity4 on accuracy than on rate, which was shifted by only 1/4-log unit. In contrast, @entity1 failed to antagonize the effects of @entity3 on either rate or accuracy. Thus it would appear that while @entity4 and @entity3 produce similar disruptions in the accuracy of a discrimination, the effects of each are differentially sensitive to antagonism by @entity1 .

title: Effects of opioids and XXXX in combination with @entity1 on the acquisition and performance of response sequences in monkeys.

answer: @entity3


abstract: The authors evaluate the quality of thoraco-mammary reconstructions in @entity3 . There was 34 @entity0 in our serie, and 27 were operating between 1982 and 2001. There was 19 @entity0 and 8 @entity0 ; the mean age was 19 years (9-40 years). Because of the clinical variability, the authors propose a classification of the @entity1 's importance in 3 degrees. In our serie, there @entity2 % of degree I, 53% of degree II and 12% of degree III. Each @entity0 had an average of 2 general anaesthesias (1-6). For the first operation time, @entity0 had translation of the homolateral latissimus dorsi muscle flap in 25%, and a thoracic prosthese in 75%. @entity0 had mammary prosthese in 50%, expansion prosthese in 20%, mammary prosthese and thoracic prosthese in 20%, muscle flap in 10%. The same @entity0 analysed the results in terms: good, middle or bad. The results are good in 67%, middle in 22%, poor in 11%. In degree 1, the results are always good; in degree II, they are good in 59%, middle in 29% and poor in 12%; in degree III, the results are good, middle and poor in 33%.

title: [ XXXX : clinic series and thoraco-mammary reconstruction. Report of 27 cases].

answer: @entity3


abstract: @entity8 is known to be induced by @entity6 including @entity5 ( @entity5 ). The constitutive and @entity5 -inducible transcriptional expression of @entity1 @entity8 is known to be cell-specific. In order to identify the cis-elements that cell-specifically regulate the constitutive and @entity5 -inducible transcription of @entity8 , we constructed luciferase reporter plasmids containing a series of deletions of the XRE core sequence in the 5'-flanking region of the @entity1 @entity8 gene. Luciferase assays were performed with MCF-7 ( @entity0 ), HepG2 ( @entity3 ), LS-180 ( @entity4 ), and OMC-3 ( @entity2 ) cells. Although there were large differences in the relative luciferase activity and inducibility between these four cell lines, the contribution of each reporter construct was similar. Constitutive expression increased with the regulatory elements that are present at -910 to -852 and -1652 to -1243. Potential enhancer elements for @entity5 -induction were located from -1022 to -852 including three XREs, XRE3 at -853, XRE4 at -940, and XRE5 at -989. Gel shift analyses revealed binding of the @entity9 / @entity10 heterodimer to XRE2 at -834, XRE3 at -853, XRE6 at -1024, and XRE7 at -1490. In addition, the binding of a nuclear transcriptional factor, @entity7 , near XRE2 and XRE8 was observed. It was suggested that mutual interaction of XRE2 and XRE3 is important for transcriptional regulation, and that the @entity7 binding to the @entity7 -like motif (-824) enhances both the constitutive and inducible transcriptional activities of the @entity1 @entity8 gene.

title: Critical enhancer region to which XXXX / @entity10 and @entity7 bind in the @entity1 @entity8 gene.

answer: @entity9


abstract: @entity8 is known to be induced by @entity6 including @entity5 ( @entity5 ). The constitutive and @entity5 -inducible transcriptional expression of @entity1 @entity8 is known to be cell-specific. In order to identify the cis-elements that cell-specifically regulate the constitutive and @entity5 -inducible transcription of @entity8 , we constructed luciferase reporter plasmids containing a series of deletions of the XRE core sequence in the 5'-flanking region of the @entity1 @entity8 gene. Luciferase assays were performed with MCF-7 ( @entity0 ), HepG2 ( @entity3 ), LS-180 ( @entity4 ), and OMC-3 ( @entity2 ) cells. Although there were large differences in the relative luciferase activity and inducibility between these four cell lines, the contribution of each reporter construct was similar. Constitutive expression increased with the regulatory elements that are present at -910 to -852 and -1652 to -1243. Potential enhancer elements for @entity5 -induction were located from -1022 to -852 including three XREs, XRE3 at -853, XRE4 at -940, and XRE5 at -989. Gel shift analyses revealed binding of the @entity9 / @entity10 heterodimer to XRE2 at -834, XRE3 at -853, XRE6 at -1024, and XRE7 at -1490. In addition, the binding of a nuclear transcriptional factor, @entity7 , near XRE2 and XRE8 was observed. It was suggested that mutual interaction of XRE2 and XRE3 is important for transcriptional regulation, and that the @entity7 binding to the @entity7 -like motif (-824) enhances both the constitutive and inducible transcriptional activities of the @entity1 @entity8 gene.

title: Critical enhancer region to which @entity9 / @entity10 and XXXX bind in the @entity1 @entity8 gene.

answer: @entity7


abstract: @entity8 is known to be induced by @entity6 including @entity5 ( @entity5 ). The constitutive and @entity5 -inducible transcriptional expression of @entity1 @entity8 is known to be cell-specific. In order to identify the cis-elements that cell-specifically regulate the constitutive and @entity5 -inducible transcription of @entity8 , we constructed luciferase reporter plasmids containing a series of deletions of the XRE core sequence in the 5'-flanking region of the @entity1 @entity8 gene. Luciferase assays were performed with MCF-7 ( @entity0 ), HepG2 ( @entity3 ), LS-180 ( @entity4 ), and OMC-3 ( @entity2 ) cells. Although there were large differences in the relative luciferase activity and inducibility between these four cell lines, the contribution of each reporter construct was similar. Constitutive expression increased with the regulatory elements that are present at -910 to -852 and -1652 to -1243. Potential enhancer elements for @entity5 -induction were located from -1022 to -852 including three XREs, XRE3 at -853, XRE4 at -940, and XRE5 at -989. Gel shift analyses revealed binding of the @entity9 / @entity10 heterodimer to XRE2 at -834, XRE3 at -853, XRE6 at -1024, and XRE7 at -1490. In addition, the binding of a nuclear transcriptional factor, @entity7 , near XRE2 and XRE8 was observed. It was suggested that mutual interaction of XRE2 and XRE3 is important for transcriptional regulation, and that the @entity7 binding to the @entity7 -like motif (-824) enhances both the constitutive and inducible transcriptional activities of the @entity1 @entity8 gene.

title: Critical enhancer region to which @entity9 / @entity10 and @entity7 bind in the @entity1 XXXX gene.

answer: @entity8


abstract: @entity8 is known to be induced by @entity6 including @entity5 ( @entity5 ). The constitutive and @entity5 -inducible transcriptional expression of @entity1 @entity8 is known to be cell-specific. In order to identify the cis-elements that cell-specifically regulate the constitutive and @entity5 -inducible transcription of @entity8 , we constructed luciferase reporter plasmids containing a series of deletions of the XRE core sequence in the 5'-flanking region of the @entity1 @entity8 gene. Luciferase assays were performed with MCF-7 ( @entity0 ), HepG2 ( @entity3 ), LS-180 ( @entity4 ), and OMC-3 ( @entity2 ) cells. Although there were large differences in the relative luciferase activity and inducibility between these four cell lines, the contribution of each reporter construct was similar. Constitutive expression increased with the regulatory elements that are present at -910 to -852 and -1652 to -1243. Potential enhancer elements for @entity5 -induction were located from -1022 to -852 including three XREs, XRE3 at -853, XRE4 at -940, and XRE5 at -989. Gel shift analyses revealed binding of the @entity9 / @entity10 heterodimer to XRE2 at -834, XRE3 at -853, XRE6 at -1024, and XRE7 at -1490. In addition, the binding of a nuclear transcriptional factor, @entity7 , near XRE2 and XRE8 was observed. It was suggested that mutual interaction of XRE2 and XRE3 is important for transcriptional regulation, and that the @entity7 binding to the @entity7 -like motif (-824) enhances both the constitutive and inducible transcriptional activities of the @entity1 @entity8 gene.

title: Critical enhancer region to which @entity9 / XXXX and @entity7 bind in the @entity1 @entity8 gene.

answer: @entity10


abstract: @entity8 is known to be induced by @entity6 including @entity5 ( @entity5 ). The constitutive and @entity5 -inducible transcriptional expression of @entity1 @entity8 is known to be cell-specific. In order to identify the cis-elements that cell-specifically regulate the constitutive and @entity5 -inducible transcription of @entity8 , we constructed luciferase reporter plasmids containing a series of deletions of the XRE core sequence in the 5'-flanking region of the @entity1 @entity8 gene. Luciferase assays were performed with MCF-7 ( @entity0 ), HepG2 ( @entity3 ), LS-180 ( @entity4 ), and OMC-3 ( @entity2 ) cells. Although there were large differences in the relative luciferase activity and inducibility between these four cell lines, the contribution of each reporter construct was similar. Constitutive expression increased with the regulatory elements that are present at -910 to -852 and -1652 to -1243. Potential enhancer elements for @entity5 -induction were located from -1022 to -852 including three XREs, XRE3 at -853, XRE4 at -940, and XRE5 at -989. Gel shift analyses revealed binding of the @entity9 / @entity10 heterodimer to XRE2 at -834, XRE3 at -853, XRE6 at -1024, and XRE7 at -1490. In addition, the binding of a nuclear transcriptional factor, @entity7 , near XRE2 and XRE8 was observed. It was suggested that mutual interaction of XRE2 and XRE3 is important for transcriptional regulation, and that the @entity7 binding to the @entity7 -like motif (-824) enhances both the constitutive and inducible transcriptional activities of the @entity1 @entity8 gene.

title: Critical enhancer region to which @entity9 / @entity10 and @entity7 bind in the XXXX @entity8 gene.

answer: @entity1


abstract: New guidelines have recommended that @entity4 in combination with @entity5 be used for prophylaxis of @entity8 in @entity0 with prosthetic heart valves. This article reviews some of the important and practical considerations for its use by the dentist. @entity4 is an @entity10 antibiotic most exclusively reserved for treatment of serious @entity2 caused by gram-negative bacteria in which less toxic antibacterials are ineffective. It has also been shown to be impressive in combination with @entity1 in treating high-risk @entity6 @entity0 . All strains of enterococci that are resistant to @entity1 plus @entity9 are almost always sensitive to @entity1 plus @entity4 . There is minimal absorption into the bloodstream from the gastrointestinal tract after oral administration but rapid absorption after intramuscular injection. Peak serum concentrations appear 30 to 90 minutes after intramuscular injection. The T1/2 is 2 hours, and in normal kidneys 85% to 95% of the drug is excreted within 24 hours by glomerular filtration. @entity7 and nephrotoxicity are the most serious toxic effects resulting from @entity4 therapy. The incidence of @entity7 is about 2%, with affected @entity0 experiencing vestibular effects rather than @entity3 . Nephrotoxicity is usually not seen before the @entity0 has had 5 to 7 days of frequent dosing for treatment of @entity2 ; the incidence is 2% to 4%. There are no data to suggest that @entity7 or nephrotoxicity will occur in the @entity0 given a single intramuscular injection of @entity4 for the prophylaxis of @entity8 . A single intramuscular or intravenous injection each of @entity5 and @entity4 should provide adequate blood levels for protection in the @entity6 @entity0 for at least 4 to 5 hours.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX for prophylaxis of @entity8 : a review for the dentist.

answer: @entity4


abstract: New guidelines have recommended that @entity4 in combination with @entity5 be used for prophylaxis of @entity8 in @entity0 with prosthetic heart valves. This article reviews some of the important and practical considerations for its use by the dentist. @entity4 is an @entity10 antibiotic most exclusively reserved for treatment of serious @entity2 caused by gram-negative bacteria in which less toxic antibacterials are ineffective. It has also been shown to be impressive in combination with @entity1 in treating high-risk @entity6 @entity0 . All strains of enterococci that are resistant to @entity1 plus @entity9 are almost always sensitive to @entity1 plus @entity4 . There is minimal absorption into the bloodstream from the gastrointestinal tract after oral administration but rapid absorption after intramuscular injection. Peak serum concentrations appear 30 to 90 minutes after intramuscular injection. The T1/2 is 2 hours, and in normal kidneys 85% to 95% of the drug is excreted within 24 hours by glomerular filtration. @entity7 and nephrotoxicity are the most serious toxic effects resulting from @entity4 therapy. The incidence of @entity7 is about 2%, with affected @entity0 experiencing vestibular effects rather than @entity3 . Nephrotoxicity is usually not seen before the @entity0 has had 5 to 7 days of frequent dosing for treatment of @entity2 ; the incidence is 2% to 4%. There are no data to suggest that @entity7 or nephrotoxicity will occur in the @entity0 given a single intramuscular injection of @entity4 for the prophylaxis of @entity8 . A single intramuscular or intravenous injection each of @entity5 and @entity4 should provide adequate blood levels for protection in the @entity6 @entity0 for at least 4 to 5 hours.(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity4 for prophylaxis of XXXX : a review for the dentist.

answer: @entity8


abstract: OBJECTIVE: To examine the seroprevalence, correlates, and characteristics of undetected @entity2 in a large adult population sample in Cambridge, UK. METHODS: The Cambridge General Practice Health Study invited individuals from 12 general practices, aged 45-76 years, to attend for a health survey that included a bone density measurement, between 1990 and 1995. A total of 7550 participants' serum samples were tested for antiendomysial antibody ( @entity8 ). Seroprevalence of undetected @entity2 was based on @entity8 positivity. Differences between @entity8 positive and negative @entity0 of various physiological correlates and reported characteristics were estimated by multivariate logistic and linear regression and adjusted for age, sex, social class, and smoking behaviour. RESULTS: The seroprevalence of undetected @entity2 in this general population sample aged 45-76 was 1.2% (95% confidence interval (CI) 0.9-1.4). @entity8 positive @entity0 (n=87) were on average slightly lighter by 2.2 kg (p=0.08), were more likely to have reported their general health as being "good or excellent" ( @entity9 (95% CI 0.90-3.46)), and were less likely to report being a current smoker (OR for current versus never 0.36 (95% CI 0.14-0.90)) than @entity8 negative @entity0 . @entity8 positivity was associated with an 8% reduction in mean serum @entity3 (0.5 mmol/l; p<0.01) and reductions in mean haemoglobin (0.3 g/dl; p<0.01), total protein (1.0 g/l; p<0.05), and corrected serum @entity7 (0.02 mmol/l; p<0.05). There was an increased risk of @entity4 in @entity8 positive @entity0 (OR 3.1 (95% CI 1.3-7.2)) and of mild @entity6 (OR 4.6 (95% CI 2.5-8.2)) compared with @entity8 negative @entity0 . CONCLUSIONS: Undetected @entity2 is likely to affect approximately 1% of the population of England aged 45-76 years, a value similar to several other countries. Those affected report "better health" but they do have an increased risk of @entity4 and mild @entity6 . In contrast, they have a favourable cardiovascular risk profile that may afford protection from @entity5 and @entity1 .

title: Seroprevalence, correlates, and characteristics of undetected XXXX in England.

answer: @entity2


abstract: BACKGROUND: Tumour @entity3 factor production is increased in the mucosa of @entity0 with active @entity2 . The benefits of infliximab in @entity1 are established. We investigated its efficacy in @entity2 . METHODS: We conducted a randomised placebo controlled trial of infliximab (5 mg/kg) in the treatment of @entity2 . Infusions were given at weeks 0 and 2. Disease activity and quality of life were recorded over eight weeks of follow up. Remission was defined as an @entity2 symptom score (UCSS) of < or =2 and/or Baron score of 0 at week 6. @entity0 not in remission were offered open label infliximab 10 mg/kg and reviewed two weeks later. RESULTS: After two weeks, there was no statistically significant difference between the infliximab and placebo groups in the proportion of @entity0 with a Baron score of 0 (13% (3/23) v 5% (1/19) (95% confidence interval (CI) -9% to 24%); p=0.74). After six weeks, remission (UCSS < or =2) rates were 39% (9/23) versus 30% (6/20) (95% CI -19 to 34%; p=0.76). The median improvement in UCSS was 3 for the infliximab group and 2.5 for the placebo group (p=0.82, Mann-Whitney U test). A Baron score of 0 was likely in either group (26% (6/23) v 30% (6/20) (95% CI -30% to 23%); p=0.96). Improvement in the IBDQ and EuroQol was not significantly different between the groups (p=0.22 and 0.3, respectively, Mann-Whitney U test). Twenty eligible @entity0 were given open labelled infusions. Remission was achieved in 3/11 (27%) @entity0 initially treated with infliximab and in 1/9 (11%) @entity0 treated with placebo. CONCLUSION: These data do not support the use of infliximab in the management of moderately active @entity2 .

title: Infliximab in moderately severe XXXX : a randomised controlled trial.

answer: @entity2


abstract: BACKGROUND: Cytokines produced in mesenteric lymph nodes of cirrhotic @entity2 with bacterial translocation may participate in circulatory alterations of @entity4 . AIM: To investigate whether cirrhotic @entity0 present an increased local generation of cytokines in mesenteric lymph nodes. METHODS: Mesenteric lymph nodes from 26 cirrhotic and 10 control @entity0 were assessed for @entity1 @entity3 factor alpha ( @entity5 ) and @entity7 mRNA and protein expression by competitive reverse transcription-polymerase chain reaction, and by enzyme immunoassay and immunohistochemistry, respectively. RESULTS: @entity7 levels were not different between cirrhotics and controls. Protein and mRNA @entity5 levels in mesenteric lymph nodes from cirrhotics were higher than in controls (p<0.05). Tissue expression of @entity5 by immunohistochemistry was more abundant in cirrhotics. @entity8 @entity0 showed higher @entity5 levels (47 (34-54) pg/mg protein) than @entity0 without @entity8 (18 (17-25) pg/mg protein) (p<0.001). Elevated @entity5 levels (>28 pg/mg protein) in cirrhotics were associated with a higher @entity0 -Pugh score, the antecedent of @entity8 , a lower prothrombin rate, and higher @entity6 and blood @entity5 levels. The strongest association, confirmed by multivariate analysis, was with the presence of @entity8 (p<0.001). @entity10 after transplantation, mainly by enteric bacteria, were only detected in @entity0 with high @entity5 levels in mesenteric lymph nodes (33% of @entity0 ; p=0.05). CONCLUSION: @entity0 with advanced @entity9 , and especially with @entity8 , have increased local production of @entity5 in mesenteric lymph nodes that, in common with experimental @entity4 , may also be induced by bacterial translocation.

title: Increased @entity1 @entity3 factor alpha production in mesenteric lymph nodes of cirrhotic @entity0 with XXXX .

answer: @entity8


abstract: BACKGROUND: Cytokines produced in mesenteric lymph nodes of cirrhotic @entity2 with bacterial translocation may participate in circulatory alterations of @entity4 . AIM: To investigate whether cirrhotic @entity0 present an increased local generation of cytokines in mesenteric lymph nodes. METHODS: Mesenteric lymph nodes from 26 cirrhotic and 10 control @entity0 were assessed for @entity1 @entity3 factor alpha ( @entity5 ) and @entity7 mRNA and protein expression by competitive reverse transcription-polymerase chain reaction, and by enzyme immunoassay and immunohistochemistry, respectively. RESULTS: @entity7 levels were not different between cirrhotics and controls. Protein and mRNA @entity5 levels in mesenteric lymph nodes from cirrhotics were higher than in controls (p<0.05). Tissue expression of @entity5 by immunohistochemistry was more abundant in cirrhotics. @entity8 @entity0 showed higher @entity5 levels (47 (34-54) pg/mg protein) than @entity0 without @entity8 (18 (17-25) pg/mg protein) (p<0.001). Elevated @entity5 levels (>28 pg/mg protein) in cirrhotics were associated with a higher @entity0 -Pugh score, the antecedent of @entity8 , a lower prothrombin rate, and higher @entity6 and blood @entity5 levels. The strongest association, confirmed by multivariate analysis, was with the presence of @entity8 (p<0.001). @entity10 after transplantation, mainly by enteric bacteria, were only detected in @entity0 with high @entity5 levels in mesenteric lymph nodes (33% of @entity0 ; p=0.05). CONCLUSION: @entity0 with advanced @entity9 , and especially with @entity8 , have increased local production of @entity5 in mesenteric lymph nodes that, in common with experimental @entity4 , may also be induced by bacterial translocation.

title: Increased @entity1 XXXX factor alpha production in mesenteric lymph nodes of cirrhotic @entity0 with @entity8 .

answer: @entity3


abstract: BACKGROUND: Cytokines produced in mesenteric lymph nodes of cirrhotic @entity2 with bacterial translocation may participate in circulatory alterations of @entity4 . AIM: To investigate whether cirrhotic @entity0 present an increased local generation of cytokines in mesenteric lymph nodes. METHODS: Mesenteric lymph nodes from 26 cirrhotic and 10 control @entity0 were assessed for @entity1 @entity3 factor alpha ( @entity5 ) and @entity7 mRNA and protein expression by competitive reverse transcription-polymerase chain reaction, and by enzyme immunoassay and immunohistochemistry, respectively. RESULTS: @entity7 levels were not different between cirrhotics and controls. Protein and mRNA @entity5 levels in mesenteric lymph nodes from cirrhotics were higher than in controls (p<0.05). Tissue expression of @entity5 by immunohistochemistry was more abundant in cirrhotics. @entity8 @entity0 showed higher @entity5 levels (47 (34-54) pg/mg protein) than @entity0 without @entity8 (18 (17-25) pg/mg protein) (p<0.001). Elevated @entity5 levels (>28 pg/mg protein) in cirrhotics were associated with a higher @entity0 -Pugh score, the antecedent of @entity8 , a lower prothrombin rate, and higher @entity6 and blood @entity5 levels. The strongest association, confirmed by multivariate analysis, was with the presence of @entity8 (p<0.001). @entity10 after transplantation, mainly by enteric bacteria, were only detected in @entity0 with high @entity5 levels in mesenteric lymph nodes (33% of @entity0 ; p=0.05). CONCLUSION: @entity0 with advanced @entity9 , and especially with @entity8 , have increased local production of @entity5 in mesenteric lymph nodes that, in common with experimental @entity4 , may also be induced by bacterial translocation.

title: Increased XXXX @entity3 factor alpha production in mesenteric lymph nodes of cirrhotic @entity0 with @entity8 .

answer: @entity1


abstract: BACKGROUND: Cytokines produced in mesenteric lymph nodes of cirrhotic @entity2 with bacterial translocation may participate in circulatory alterations of @entity4 . AIM: To investigate whether cirrhotic @entity0 present an increased local generation of cytokines in mesenteric lymph nodes. METHODS: Mesenteric lymph nodes from 26 cirrhotic and 10 control @entity0 were assessed for @entity1 @entity3 factor alpha ( @entity5 ) and @entity7 mRNA and protein expression by competitive reverse transcription-polymerase chain reaction, and by enzyme immunoassay and immunohistochemistry, respectively. RESULTS: @entity7 levels were not different between cirrhotics and controls. Protein and mRNA @entity5 levels in mesenteric lymph nodes from cirrhotics were higher than in controls (p<0.05). Tissue expression of @entity5 by immunohistochemistry was more abundant in cirrhotics. @entity8 @entity0 showed higher @entity5 levels (47 (34-54) pg/mg protein) than @entity0 without @entity8 (18 (17-25) pg/mg protein) (p<0.001). Elevated @entity5 levels (>28 pg/mg protein) in cirrhotics were associated with a higher @entity0 -Pugh score, the antecedent of @entity8 , a lower prothrombin rate, and higher @entity6 and blood @entity5 levels. The strongest association, confirmed by multivariate analysis, was with the presence of @entity8 (p<0.001). @entity10 after transplantation, mainly by enteric bacteria, were only detected in @entity0 with high @entity5 levels in mesenteric lymph nodes (33% of @entity0 ; p=0.05). CONCLUSION: @entity0 with advanced @entity9 , and especially with @entity8 , have increased local production of @entity5 in mesenteric lymph nodes that, in common with experimental @entity4 , may also be induced by bacterial translocation.

title: Increased @entity1 @entity3 factor alpha production in mesenteric lymph nodes of cirrhotic XXXX with @entity8 .

answer: @entity0


abstract: BACKGROUND AND AIM: @entity1 after severe @entity1 depends in part on proliferation and differentiation of hepatic progenitor cells (HPCs). Under these conditions they must be able to withstand the toxic milieu of the damaged liver. @entity2 binding cassette (ABC) transporters are cytoprotective efflux pumps that may contribute to the preservation of these cells. The aim of this study was to determine the ABC transporter phenotype of HPCs. METHODS: HPC activation was studied in @entity0 treated with @entity3 ( @entity3 ) followed by partial hepatectomy (PHx). ABC transporter gene expression was determined by real time detection reverse transcription-polymerase chain reaction in isolated HPCs, hepatocytes, cholangiocytes, and cultured progenitor cell-like RLF phi 13 cells and by immunohistochemistry of total liver samples. ABC transporter efflux activity was studied in RLF phi 13 cells by flow cytometry. RESULTS: 2-AAF/PHx treated animals showed increased hepatic mRNA levels of the genes encoding multidrug resistance proteins Mdr1b, @entity8 , and @entity9 . Immunohistochemistry demonstrated expression of @entity8 and @entity9 proteins in periportal progenitor cells and of the Mdr1b protein in periportal hepatocytes. Freshly isolated @entity6 positive cells and cultured RLF phi 13 progenitor cells highly expressed @entity8 and @entity9 mRNA while the hepatocyte specific transporters @entity11 , @entity10 , @entity7 , and @entity12 were only minimally expressed. Blocking @entity8 activity by @entity4 resulted in accumulation of the @entity8 specific substrate @entity5 in RLF phi 13 cells. CONCLUSION: HPCs express high levels of active @entity8 and @entity9 . These may have a cytoprotective role in conditions of severe hepatotoxicity.

title: XXXX binding cassette transporter gene expression in @entity0 liver progenitor cells.

answer: @entity2


abstract: BACKGROUND AND AIM: @entity1 after severe @entity1 depends in part on proliferation and differentiation of hepatic progenitor cells (HPCs). Under these conditions they must be able to withstand the toxic milieu of the damaged liver. @entity2 binding cassette (ABC) transporters are cytoprotective efflux pumps that may contribute to the preservation of these cells. The aim of this study was to determine the ABC transporter phenotype of HPCs. METHODS: HPC activation was studied in @entity0 treated with @entity3 ( @entity3 ) followed by partial hepatectomy (PHx). ABC transporter gene expression was determined by real time detection reverse transcription-polymerase chain reaction in isolated HPCs, hepatocytes, cholangiocytes, and cultured progenitor cell-like RLF phi 13 cells and by immunohistochemistry of total liver samples. ABC transporter efflux activity was studied in RLF phi 13 cells by flow cytometry. RESULTS: 2-AAF/PHx treated animals showed increased hepatic mRNA levels of the genes encoding multidrug resistance proteins Mdr1b, @entity8 , and @entity9 . Immunohistochemistry demonstrated expression of @entity8 and @entity9 proteins in periportal progenitor cells and of the Mdr1b protein in periportal hepatocytes. Freshly isolated @entity6 positive cells and cultured RLF phi 13 progenitor cells highly expressed @entity8 and @entity9 mRNA while the hepatocyte specific transporters @entity11 , @entity10 , @entity7 , and @entity12 were only minimally expressed. Blocking @entity8 activity by @entity4 resulted in accumulation of the @entity8 specific substrate @entity5 in RLF phi 13 cells. CONCLUSION: HPCs express high levels of active @entity8 and @entity9 . These may have a cytoprotective role in conditions of severe hepatotoxicity.

title: @entity2 binding cassette transporter gene expression in XXXX liver progenitor cells.

answer: @entity0


abstract: OBJECTIVE: To examine job stability moderating variables and develop a postinjury work stability prediction model. DESIGN: Multicenter analysis of individuals with @entity1 ( @entity1 ) who returned for follow-up at 1, 2, and 3, or 4 years postinjury, were of working age (between 18 and 62 years of age at injury), and were working preinjury. SETTING: Six National Institute on Disability and Rehabilitation @entity1 Model System centers for coordinated acute and rehabilitation care. @entity0 : A total of 186 adults with @entity1 were included in the study. MAIN OUTCOME MEASURES: Job stability was categorized as stably employed (employed at all 3 follow-up intervals); unstably employed (employed at one or two of all three follow-up intervals); and unemployed (unemployed at all three follow-up intervals). RESULTS: After injury, 34% were stably employed, 27% were unstably employed, and 39% were unemployed at all three follow-up intervals. Minority group members, @entity0 who did not complete high school, and unmarried @entity0 were more likely to be unemployed. Driving independence was highly influential and significantly related to employment stability. A discriminant function analysis, which included age, length of unconsciousness and Disability Rating Scale scores at 1 year postinjury, accurately predicted job stability groupings. CONCLUSION: Data analysis provided evidence that employment stability is predictable with a combination of functional, demographic, and injury severity variables. Identification of @entity0 at risk for poor employment outcomes early on can facilitate rehabilitation planning and intervention.

title: Moderating factors in return to work and job stability after XXXX .

answer: @entity1


abstract: OBJECTIVE: To test the efficacy of a portable voice organizer in helping @entity0 with @entity1 ( @entity1 ) to recall therapy goals and plans discussed with their clinical case managers. DESIGN: Prospective within-subjects trial, in which individualized therapy goals were randomly assigned to intervention or no intervention. SETTING: Comprehensive postacute @entity1 rehabilitation program. @entity0 : Ten @entity0 with moderate to severe @entity1 enrolled from 3 months to 18 years after injury. OUTCOME MEASURE: Memory for therapy goals. Clinicians generated statements describing six current therapy goals, half of which were randomly assigned to be recorded on a voice organizer during the next case management session. @entity0 selected three times per day to listen to the recorded goals, prompted by an alarm. One-week recall was tested using both free- and cued-recall formats. RESULTS: Recorded goals were recalled better than unrecorded goals and appeared to be associated with better awareness or follow-through with therapy objectives. CONCLUSION: Portable electronic devices have the potential to assist with treatment areas beyond tasks involving prospective memory.

title: Use of a portable voice organizer to remember therapy goals in XXXX rehabilitation: a within-subjects trial.

answer: @entity1


abstract: PURPOSE: Optimal out-of-hospital @entity1 (OHCA) airway management strategies are still controversial. Recent studies reported survival was higher among @entity0 who received bag-valve-mask (BVM) than those receiving endotracheal intubation (ETI) or supraglottic airway (SGA). The aim of this study was to compare neurologically favorable survival outcomes among adult nontraumatic OHCA @entity0 by prehospital airway. METHODS: We used the Korean nationwide OHCA cohort database from 2010 to 2013. The inclusion criteria were all OHCA adults with presumed cardiac etiology, resuscitated by level-1 emergency medical technician. @entity0 were excluded if their information about the method of prehospital airway or clinical outcomes at hospital discharge could not be captured. The primary outcome was neurologically favorable survival to discharge. We compared the outcomes among 3 groups (ETI, SGA, or BVM) by prehospital airway using multivariable logistic regression with interaction model. RESULTS: Of 98896 @entity0 with OHCA, 32513 were included in analysis. @entity0 receiving BVM were 29684 and 2829 underwent advanced airway management including 1634 with SGA and 1195 with ETI. The odds of neurologically favorable survival to discharge was significantly higher in the ETI group compared to the BVM group (adjusted OR, 1.405; 95% CI, 1.1001-1.971). In the interaction model by witnessed status, the effect of ETI on good clinical outcomes was shown only in the @entity0 whose arrest was unwitnessed. CONCLUSION: In this Korean nationwide, population-based OHCA cohort, neurologically favorable survival to hospital discharge rates was significantly higher among @entity0 who received ETI than those receiving BVM or SGA.

title: Prehospital endotracheal intubation and survival after out-of-hospital XXXX : results from the Korean nationwide registry.

answer: @entity1


abstract: OBJECTIVES: To investigate the effect of @entity4 gene and b-glucuronidase activity on stone formation in @entity0 with @entity6 ( @entity6 ). METHODS: A total of 103 @entity0 with @entity6 and 102 controls with no specific @entity2 history were enrolled into the study. @entity5 and @entity7 polymorphisms of @entity4 gene were analyzed with PCR method. Serum levels of @entity1 and @entity3 and 24-h urine levels of b-glucuronidase activity, @entity1 and @entity3 levels were measured biochemically. RESULTS: A total of 103 of @entity0 were male (50.2  %) and 102 were female (49.8  %) (p 0.945). Twenty-four-hour urine levels of @entity1 were significantly higher in @entity6 group, whereas no difference was observed in @entity3 levels (p  <  0.001, p 0.074, respectively). As for the @entity5 polymorphism, type of GG was significantly higher in the @entity0 group compared to the controls (p  =  0.02), while GA genotype was significantly higher in the controls (p  =  0.001). There was no significant difference in @entity8 and @entity7 polymorphism between the @entity0 and control groups. b-glucuronidase activity was slightly lower in the @entity0 group without significance (p 0.932).When @entity0 with GG genotype and the rest were compared, there were no significant difference in all parameters. CONCLUSIONS: Any polymorphism altering the function of @entity4 gene may result with stone formation. We found that there are more GG sequences of @entity5 gene in @entity0 with @entity6 . That may be a polymorphism of @entity4 gene which results with stone formation. Further studies with more @entity0 should be accomplished which are combining the genetic and epigenetic factors associated with @entity2 and @entity4 gene to enlighten the etiology of this disease.

title: The impact of XXXX gene polymorphisms on @entity6 .

answer: @entity4


abstract: OBJECTIVES: To investigate the effect of @entity4 gene and b-glucuronidase activity on stone formation in @entity0 with @entity6 ( @entity6 ). METHODS: A total of 103 @entity0 with @entity6 and 102 controls with no specific @entity2 history were enrolled into the study. @entity5 and @entity7 polymorphisms of @entity4 gene were analyzed with PCR method. Serum levels of @entity1 and @entity3 and 24-h urine levels of b-glucuronidase activity, @entity1 and @entity3 levels were measured biochemically. RESULTS: A total of 103 of @entity0 were male (50.2  %) and 102 were female (49.8  %) (p 0.945). Twenty-four-hour urine levels of @entity1 were significantly higher in @entity6 group, whereas no difference was observed in @entity3 levels (p  <  0.001, p 0.074, respectively). As for the @entity5 polymorphism, type of GG was significantly higher in the @entity0 group compared to the controls (p  =  0.02), while GA genotype was significantly higher in the controls (p  =  0.001). There was no significant difference in @entity8 and @entity7 polymorphism between the @entity0 and control groups. b-glucuronidase activity was slightly lower in the @entity0 group without significance (p 0.932).When @entity0 with GG genotype and the rest were compared, there were no significant difference in all parameters. CONCLUSIONS: Any polymorphism altering the function of @entity4 gene may result with stone formation. We found that there are more GG sequences of @entity5 gene in @entity0 with @entity6 . That may be a polymorphism of @entity4 gene which results with stone formation. Further studies with more @entity0 should be accomplished which are combining the genetic and epigenetic factors associated with @entity2 and @entity4 gene to enlighten the etiology of this disease.

title: The impact of @entity4 gene polymorphisms on XXXX .

answer: @entity6


abstract: PURPOSE: Increased levels of reactive @entity1 species lead to oxidative stress and @entity4 . @entity2 ( @entity3 ) is one of many low-molecular-weight endproducts of lipid peroxidation that increases with oxidative stress. The aim of this study was to determine oxidative stress in dental follicles (DFs) of radiologically asymptomatic impacted third molars (ITMs) using @entity3 . MATERIALS AND METHODS: This study involved 40 DFs of 40 @entity0 referred for clinically and radiographically asymptomatic ITMs. Forty healthy gingival tissues in the same @entity0 were obtained during surgical @entity5 as a control group. DF widths on periapical radiographs narrower than 2.5 mm were included in the study. All tissues samples were analyzed for @entity3 as an indicator of oxidative stress. RESULTS: Levels of @entity3 were significantly higher in DFs from ITMs than those from healthy gingival tissues of the same @entity0 (P < .01). CONCLUSION: The results suggest that significant oxidative stress may occur in DFs of asymptomatic ITMs. The findings suggest that increased @entity3 may play an important role in oxidative stress in DFs. In light of these preliminary findings of the present study, further investigations and comprehensive studies are required to determine the role of antioxidants that scavenge free radicals in DFs.

title: XXXX levels in dental follicles of asymptomatic impacted third molars.

answer: @entity2


abstract: PURPOSE OF THE STUDY: To investigate the haemodynamic properties of a direct endovascular aortic shunt to maintain distal aortic perfusion as an alternative of a distal shunt (left-left-, Gott shunt) in @entity3 repair. METHODS: A shunt was developed and tested in an in vitro model which should be capable of transporting a flow of 3-4 L/min with a decrease in blood pressure < 20 mmHg. Thereupon the shunt was tested in an in vivo experiment in six @entity2 to assess the possibility of its use with normal distal blood pressure. The shunt was inserted in the thoracic aorta and stayed in place for 1.5 h. Parameters were measured at six time intervals to assess organ perfusion, -function, cardiac output, proximal- and distal blood pressure and aortic- and shunt flow. PRINCIPLE FINDINGS: The mean blood flow through the shunt was 2.5 L/min. The difference of the mean blood pressure over the shunt was on average 14.20 mmHg. Parameters for coagulation disturbance and organ ischaemia were tested. The decrease in mean thrombocyte count was 299-158 (p<0.02). The venous @entity1 and the venous mesenteric @entity1 as parameters for @entity0 did not increase significantly. No significant changes occurred in angiotensin II levels. Pulsatile flow was maintained but significantly suppressed (60%) distal from the shunt. The clamp time needed to insert the shunt and the venous mesenteric @entity1 , as well as the venous @entity1 , showed high correlation, r(s) = 0.9 (p<0.05) and r(s) = 0.94 (p<0.01). This also accounted for the 2nd clamp time, both r(s) = 0.95 (p<0.05). CONCLUSION: The shunt is capable of transporting a blood flow of 2-4 L/min with an acceptable decrease in distal blood pressure. However, the time, needed to insert the shunt, was significantly associated with parameters of organ ischaemia.

title: Endoluminal aortic shunting for distal perfusion during thoracic aortal cross-clamping in a XXXX model.

answer: @entity2


abstract: Calsequestrin is a moderate-affinity, high-capacity @entity1 binding protein in the sarcoplasmic reticulum of skeletal and cardiac muscle that seems to act as an intralumenal @entity1 buffer. Two different isoforms have been described in mammals, the skeletal and cardiac isoforms, encoded by CASQ1 and CASQ2 genes, respectively. In this study, we present molecular phylogenetic evidence of a gene duplication event of both calsequestrin genes in teleosts, referred to as casq1a/casq1b and casq2a/casq2b. We obtained the entire cDNAs encoding the four genes in the @entity3 ( @entity3 Kaup). Main features and sequence identities with other fish and @entity0 calsequestrins are described. Expression profiles during larval development and in juvenile tissues were analyzed using a real-time PCR approach. In juvenile fish, casq1a and casq1b were highly expressed in skeletal muscle, whereas the highest casq2a and casq2b transcript levels were detected in heart and brain, respectively. During metamorphosis, casq2a and casq1b expression remained unchanged. In contrast, casq1a and casq2b mRNAs exhibited a continuous increase from the beginning of metamorphosis until post-metamorphosis. Transcriptional regulation of casq1 and casq2 genes by thyroid hormones (THs) was also evaluated. Larvae exposed to the goitrogen @entity2 (TU) exhibited higher casq1a mRNA levels than untreated control, whereas expression of the remaining genes did not vary significantly. Moreover, addition of exogenous T4 hormone to TU-treated larvae increased the casq1a steady-state levels with respect to the untreated control at metamorphosis climax. Comprehensively, these results demonstrate the existence of four calsequestrin genes in teleosts differentially regulated by THs.

title: Duplication of calsequestrin genes in teleosts: molecular characterization in the XXXX ( @entity3 ).

answer: @entity3


abstract: Calsequestrin is a moderate-affinity, high-capacity @entity1 binding protein in the sarcoplasmic reticulum of skeletal and cardiac muscle that seems to act as an intralumenal @entity1 buffer. Two different isoforms have been described in mammals, the skeletal and cardiac isoforms, encoded by CASQ1 and CASQ2 genes, respectively. In this study, we present molecular phylogenetic evidence of a gene duplication event of both calsequestrin genes in teleosts, referred to as casq1a/casq1b and casq2a/casq2b. We obtained the entire cDNAs encoding the four genes in the @entity3 ( @entity3 Kaup). Main features and sequence identities with other fish and @entity0 calsequestrins are described. Expression profiles during larval development and in juvenile tissues were analyzed using a real-time PCR approach. In juvenile fish, casq1a and casq1b were highly expressed in skeletal muscle, whereas the highest casq2a and casq2b transcript levels were detected in heart and brain, respectively. During metamorphosis, casq2a and casq1b expression remained unchanged. In contrast, casq1a and casq2b mRNAs exhibited a continuous increase from the beginning of metamorphosis until post-metamorphosis. Transcriptional regulation of casq1 and casq2 genes by thyroid hormones (THs) was also evaluated. Larvae exposed to the goitrogen @entity2 (TU) exhibited higher casq1a mRNA levels than untreated control, whereas expression of the remaining genes did not vary significantly. Moreover, addition of exogenous T4 hormone to TU-treated larvae increased the casq1a steady-state levels with respect to the untreated control at metamorphosis climax. Comprehensively, these results demonstrate the existence of four calsequestrin genes in teleosts differentially regulated by THs.

title: Duplication of calsequestrin genes in teleosts: molecular characterization in the @entity3 ( XXXX ).

answer: @entity3


abstract: BACKGROUND: @entity2 is the most frequent complication associated with cryoballoon ablation for @entity3 . To date, no preventive strategy has proved effective. OBJECTIVE: We sought to assess the feasibility of diaphragmatic electromyography during cryoballoon ablation, explore the relationship between altered signals and @entity0 , and define characteristic changes that herald @entity2 . METHODS: Cryoballoon ablation was performed in the right superior pulmonary vein or superior vena cava in 16 mongrel @entity1 weighing 37.7    2.4 kg, at sites determined by phrenic nerve capture. During ablation, the phrenic nerve was paced at 60 bpm from the superior vena cava while recording diaphragmatic compound motor action potentials (CMAPs) by esophageal decapolar catheters. Diaphragmatic excursion was monitored by fluoroscopy and abdominal palpation. RESULTS: Before ablation, the CMAP amplitude was 592 (interquartile range 504, 566)  V, initial latency 21.5    4.2 ms, peak latency 64.7    21.1 ms, and duration 101.7    13.3 ms. @entity2 was obtained in all @entity1 62    34 seconds into the cryoapplication. The CMAP amplitude decreased exponentially, with no patterned changes in latencies and duration. Discriminatory analyses by receiver-operating curve characteristics identified a 30% reduction in CMAP amplitude as the most predictive cutoff value for @entity2 (c-statistic 0.965; P<.0001). This criterion presaged @entity4 , as detected by abdominal palpation, by 31    23 seconds. CONCLUSION: Diaphragmatic electromyographic signals could be reliably recorded during cryoballoon ablation. An exponential decrease in CMAP amplitude precedes @entity4 , with a 30% reduction yielding the best discriminatory potential. A promising safety margin was detected, which merits prospective validation.

title: Diaphragmatic electromyography during cryoballoon ablation: a novel concept in the prevention of XXXX .

answer: @entity0


abstract: OBJECTIVE: To analyze the development and progression of @entity3 in @entity0 and adolescents with nonambulatory spastic @entity1 . DESIGN: Retrospective longitudinal review. SETTING: Pediatric nursing home. @entity0 : A total of 110 @entity0 and adolescents <18 years of age, with @entity3 . INTERVENTIONS: N/A. MAIN OUTCOME MEASURES: Cobb angle, age, weight, height, history of @entity2 , tracheostomy. RESULTS: The Cobb angle increased with age, weight, and height in a nonlinear fashion. A square root transformation of the Cobb angle was chosen to model the nonlinear relationship between the Cobb angle and predictors. Age, height, and weight were significant univariate predictors of the square root of the Cobb angle (slopes = 0.377, 0.067, and 0.06, respectively). In the multivariate mixed model, age remained a significant predictor of the Cobb angle (slope = 0.456), but height and weight did not. If the Cobb angle was > 40   by age 12 years, @entity3 was more likely to progress than if the Cobb angle was  <= 40  . The effect of age was stronger for those with history of tracheostomy (age slope = 0.631 vs 0.281) than those without. The relationship of age and Cobb angle did not differ significantly between hip dislocated and non-hip-dislocated groups. CONCLUSIONS: Age was found to be the most significant predictor of Cobb angle, and the effect of age was greater in the tracheostomy group than in the nontracheostomy group. After adjustment for age, the weight and height were not significant predictors of Cobb angle. Cobb angles of > 40   by the age of 12 years were associated with greater increases in Cobb angle with age.

title: Natural history of XXXX in nonambulatory spastic @entity1 .

answer: @entity3


abstract: OBJECTIVE: To analyze the development and progression of @entity3 in @entity0 and adolescents with nonambulatory spastic @entity1 . DESIGN: Retrospective longitudinal review. SETTING: Pediatric nursing home. @entity0 : A total of 110 @entity0 and adolescents <18 years of age, with @entity3 . INTERVENTIONS: N/A. MAIN OUTCOME MEASURES: Cobb angle, age, weight, height, history of @entity2 , tracheostomy. RESULTS: The Cobb angle increased with age, weight, and height in a nonlinear fashion. A square root transformation of the Cobb angle was chosen to model the nonlinear relationship between the Cobb angle and predictors. Age, height, and weight were significant univariate predictors of the square root of the Cobb angle (slopes = 0.377, 0.067, and 0.06, respectively). In the multivariate mixed model, age remained a significant predictor of the Cobb angle (slope = 0.456), but height and weight did not. If the Cobb angle was > 40   by age 12 years, @entity3 was more likely to progress than if the Cobb angle was  <= 40  . The effect of age was stronger for those with history of tracheostomy (age slope = 0.631 vs 0.281) than those without. The relationship of age and Cobb angle did not differ significantly between hip dislocated and non-hip-dislocated groups. CONCLUSIONS: Age was found to be the most significant predictor of Cobb angle, and the effect of age was greater in the tracheostomy group than in the nontracheostomy group. After adjustment for age, the weight and height were not significant predictors of Cobb angle. Cobb angles of > 40   by the age of 12 years were associated with greater increases in Cobb angle with age.

title: Natural history of @entity3 in nonambulatory spastic XXXX .

answer: @entity1


abstract: PURPOSE: To evaluate the multilayer Gore-Tex patch as temporary coverage of deep, noninfectious @entity5 . DESIGN: Retrospective, interventional case series. METHODS:                 <AbstractText Label="SETTING" NlmCategory="METHODS">University Medical Center Schleswig-Holstein, Kiel, Germany. @entity0 POPULATION: Thirty-nine eyes of 38 @entity0 with noninfectious, deep @entity5 . Underlying disorders included @entity4 in 37 eyes (94.9%) and @entity2 (5.1%). Intervention procedures: Corneal defects were covered with multiple Gore-Tex layers, of which the uppermost was sutured to the @entity1 . The Gore-Tex patch was kept in place until an appropriate corneal transplant was obtained and effective systemic immunosuppression was initiated. MAIN OUTCOME MEASURES: Long-term preservation of the eye, frequency of resuturing of the Gore-Tex patch, and best-corrected visual acuity. RESULTS: In 38 cases, the eye could be preserved. In 10 eyes, additional sutures were required. Before surgery, the mean best-corrected visual acuity (logMAR) was 1.14    0.45 (20/250), and that at final follow-up was 1.13    0.41 (20/250). The Gore-Tex patch remained in place 4 days to 32 months (mean, 6.4    8.3 months) until corneal transplantation (27 eyes) or until an alternative way of defect coverage could be performed. Three eyes did not require further coverage after explantation of the Gore-Tex patch. In 6 eyes, either the Gore-Tex patch was kept in place or the @entity0 died. CONCLUSIONS: Temporary coverage of deep @entity5 with multilayer Gore-Tex patches allows time until an appropriate corneal transplant is obtained. The technique is particularly useful in @entity0 with underlying @entity3 , because an effective systemic immunosuppression can be initiated before corneal transplantation.

title: Multilayered Gore-Tex patch for temporary coverage of deep noninfectious XXXX : surgical procedure and clinical experience.

answer: @entity5


abstract: OBJECTIVE: To determine the frequency of de novo urgency after tension-free vaginal tape (TVT) compared with the transobturator tape (TOT) procedure in @entity0 with @entity2 ( @entity2 ). STUDY DESIGN: Prospective study of all consecutive @entity0 with urodynamically confirmed @entity2 undergoing anti- @entity1 surgery between January 2000 and January 2008. All procedures were performed by experienced urogynaecologists well trained in TVT and TOT surgery. Assessments were carried out at 1, 6, 12 and, 36 months after surgery. RESULTS: The study population included 366 @entity0 (mean age 59.5 years), 243 in the TVT group and 123 in the TOT group. The groups were similar in terms of demographics, preoperative data, and cure rates. De novo urgency occurred in 13.4% of @entity0 at 6 months after surgery, in 19.3% at 12 months, and in 22.1% at 36 months. De novo urgency was significantly more frequent in the TVT group than in the TOT group at 12 (22.2% vs 11.2%, P=0.025), 24 (24.8% vs 12.3%, P=0.033), and 36 (0% vs 24.7%, P=0.034) months. Cure rates were similar in both groups. The final adjusted cure rate was 87.3% (319/366). CONCLUSION: Treatment of @entity2 using the TOT procedure was associated with a lower rate of de novo urgency.

title: De novo urgency after tension-free vaginal tape versus transobturator tape procedure for XXXX .

answer: @entity2


abstract: INTRODUCTION: @entity0 mesenchymal stem cells (hMSCs) have been approved for therapeutic applications. Despite the advances in this field, in vitro approaches are still required to improve the essential indices that would pave the way to a bright horizon for an efficient transplantation in the future. Nanotechnology could help to improve these approaches. Studies signified the important role of @entity1 in stem cell metabolism and efficiency of @entity2 chelation application for stem cell expansion   METHODS: For the first time, based on novel Nanochelating technology, we design an @entity1 containing @entity2 chelator nano complex, GFc7 and examined on hMSCs during in vitro expansion. In this study, the hMSCs were isolated, characterized and expanded in vitro in two media (with or without GFc7). Then proliferation, cell viability, cell cycle analysis, surface markers, HLADR, pluripotency genes expression, homing and antioxidative defense at genes and protein expression were investigated. Also we analyzed the spontaneous differentiation and examined osteogenic and lipogenic differentiation.   RESULTS: GFc7 affected the expression of key genes, improving both the @entity3 and fitness of the cells in a precise and balanced manner. We observed significant increases in cell proliferation, enhanced expression of pluripotency genes and homing markers, improved antioxidative defense, repression of genes involved in spontaneous differentiation and exposing the hMSCs to differentiation medium indicated that pretreatment with GFc7 increased the quality and rate of differentiation. CONCLUSIONS: Thus, GFc7 appears to be a potential new supplement for cell culture medium for increasing the efficiency of transplantation.

title: Nanochelating based nanocomplex, GFc7, improves quality and quantity of XXXX mesenchymal stem cells during in vitro expansion.

answer: @entity0


abstract: In this work, chemiluminescence (CL) method was combined with microfluidic paper-based analytical device ( PAD) to establish a novel CL  PAD biosensor for the first time. This novel CL  PAD biosensor was based on enzyme reaction which produced @entity0 while decomposing the substrate and the CL reaction between @entity2 derivative and generated @entity0 in acid medium. Microchannels in  PAD were fabricated by cutting method. And the possible CL assay principle of this CL  PAD biosensor was explained. @entity2 derivative system was used to reach the purpose of high sensitivity and well-defined signal for this CL  PAD biosensor. And the optimum reaction conditions were investigated. The quantitative determination of @entity1 could be achieved by this CL  PAD biosensor with accurate and satisfactory result. And this biosensor could provide good reproducible results upon storage at 4  C for at least 10 weeks. The successful integration of  PAD and CL reaction made the final biosensor inexpensive, easy-to-use, low-volume, and portable for @entity1 determination, which also greatly reduces the cost and increases the efficiency required for an analysis. We believe this simple, practical CL  PAD biosensor will be of interest for use in areas such as disease diagnosis.

title: A novel chemiluminescence paper microfluidic biosensor based on enzymatic reaction for XXXX determination.

answer: @entity1


abstract: Prior studies of observer agreement of the clinical exam of @entity0 with @entity2 have focused on small numbers of specially trained observers, often in the setting of clinical trials. Our objective was to evaluate interobserver reliability in the physical exam of acute pediatric wheezing and @entity2 among a large group of diverse examiners, in a setting of routine clinical practice, and without prior special training. The setting was a large urban @entity0 's hospital. Observers were attending pediatric emergency physicians and fellows; hospital respiratory therapists; and @entity1 ( @entity1 ) nurses. @entity0 were @entity0 receiving nebulized medications for wheezing in the @entity1 or inpatient @entity2 unit. Pairs of observers simultaneously but independently rated work of breathing, wheeze, decreased air entry, prolonged expiration, @entity3 , respiratory rate, mental status, and global (or overall) severity using a structured exam template. A total score for each exam was also evaluated. A total of 230 pairs of observations were performed; mean @entity0 age was 5.3 years. For all pairs, the weighted kappa statistics for the exam components ranged from 0.61 to 0.74 (moderate or substantial agreement). The global severity category and total score had weighted kappas of 0.80 and 0.82, respectively (excellent agreement). Agreement was generally somewhat lower for unlike (different profession) observer pairs than for like observer pairs, but remained acceptable. Agreement in two age groups (< or = 3 years old and > or = 4) was at least moderate for all exam components analyzed. Spearman rank correlations between individual exam components and the global assessments of @entity0 severity were all greater than 0.5, indicating at least moderate to good correlations. We found substantial interobserver agreement among a broad range of examiners in the components of the clinical examination of acute wheezing in both younger and older @entity0 . This is contrary to the commonly held observation that the poor interobserver reliability of physical exam findings in @entity2 may limit their usefulness as @entity2 outcome measures. Support for use of a structured respiratory exam format or template in @entity2 guidelines was also shown.

title: Interrater agreement in the clinical evaluation of acute pediatric XXXX .

answer: @entity2


abstract: In asthmatics, the score of bronchoconstriction-associated @entity2 at 20% fall in forced expiratory volume at first second (FEV1) evaluated on a Borg scale ( @entity4 ) is a tool successfully used to measure the perception of symptoms. This prospective laboratory study evaluated the applicability of @entity4 to assess the @entity2 induced by ultrasonically nebulized distilled water (UNDW) and @entity3 (M) and its reproducibility. Twenty-two mild and clinically stable asthmatic @entity0 performed UNDW and M challenge tests. The @entity4 was calculated by linear interpolation of the last two points of the perception/fall in FEV1 curve of the UNDW and M tests. The reproducibility of @entity4 M was assessed by repeating measurements on 2 separate days by 3 weeks. @entity4 UNDW and @entity4 M did not differ and were respectively 1.82 +/- 1.85 and 2.03 +/- 1.86. They were significantly related (rs=0.63; p<0.01) and the bias between @entity4 UNDW and @entity4 M was -0.21 with the limits of agreement ranging from -3.2 to 3.6. The intraclass correlation coefficient for repeated measurement of @entity4 M was 0.82; the bias between the two measurements was 0.2 with the limits of agreement ranging from -2.8 to 3.2. All @entity0 had a measurable @entity2 perception degree on a Borg scale during both distilled water challenges and @entity3 . @entity1 @entity0 with normal, exaggerated or poor @entity2 perception were also similar for both stimuli. In addition, @entity4 showed a good reproducibility and this allows the serial evaluation of @entity0 's @entity2 perception by this technique in clinical settings and in the physiology laboratory.

title: Assessment of XXXX perception by Borg scale in asthmatic @entity0 : reproducibility and applicability to different stimuli.

answer: @entity2


abstract: In asthmatics, the score of bronchoconstriction-associated @entity2 at 20% fall in forced expiratory volume at first second (FEV1) evaluated on a Borg scale ( @entity4 ) is a tool successfully used to measure the perception of symptoms. This prospective laboratory study evaluated the applicability of @entity4 to assess the @entity2 induced by ultrasonically nebulized distilled water (UNDW) and @entity3 (M) and its reproducibility. Twenty-two mild and clinically stable asthmatic @entity0 performed UNDW and M challenge tests. The @entity4 was calculated by linear interpolation of the last two points of the perception/fall in FEV1 curve of the UNDW and M tests. The reproducibility of @entity4 M was assessed by repeating measurements on 2 separate days by 3 weeks. @entity4 UNDW and @entity4 M did not differ and were respectively 1.82 +/- 1.85 and 2.03 +/- 1.86. They were significantly related (rs=0.63; p<0.01) and the bias between @entity4 UNDW and @entity4 M was -0.21 with the limits of agreement ranging from -3.2 to 3.6. The intraclass correlation coefficient for repeated measurement of @entity4 M was 0.82; the bias between the two measurements was 0.2 with the limits of agreement ranging from -2.8 to 3.2. All @entity0 had a measurable @entity2 perception degree on a Borg scale during both distilled water challenges and @entity3 . @entity1 @entity0 with normal, exaggerated or poor @entity2 perception were also similar for both stimuli. In addition, @entity4 showed a good reproducibility and this allows the serial evaluation of @entity0 's @entity2 perception by this technique in clinical settings and in the physiology laboratory.

title: Assessment of @entity2 perception by Borg scale in asthmatic XXXX : reproducibility and applicability to different stimuli.

answer: @entity0


abstract: The rate of @entity2 diagnosis in reproductive age @entity0 has increased parallel to the improvements in diagnostic methods and regular gynaecological visits. Because of this organ saving surgical procedures for the preservation of reproductive and endocrine functions have gained more interest. Conservative surgical approaches for @entity2 after surgical staging include cystectomy, unilateral salpingo-oophorectomy and unilateral salpingo-oophorectomy plus contralateral cystectomy. @entity2 diagnosed in young ages tend to be low-stage low-grade @entity1 . This not only enables but also necessitates preserving the fertility of @entity0 who have not completed their family. In invasive @entity2 , fertility saving surgery is confined to early-stage and low-grade disease. But, it also had been reported in advanced stages (up to Stage IIIc). Candidates for those procedures were selected according to the FIGO stage, grade, ploidy state, histological subtypes and @entity0 ' desire. Adjuvant chemotherapy is necessary for high-risk @entity0 . The rate of recurrence following conservative and radical surgical procedures in low-stage and low-grade @entity1 are 9% and 11.6%, respectively; and disease-free and overall survival rates do not differ significantly. Prognosis of borderline @entity2 is excellent. Five and 20-year survival rates are 95% and 80%, respectively. Management of borderline @entity1 has evolved significantly in the last few decades. In contrast to invasive @entity2 , borderline @entity1 can be operated on conservatively at all stages. Chemotherapy is rarely prescribed even in advanced stages. Eighty percent of malignant germ cell @entity1 are diagnosed less than 30 years of age, and 70-75% of @entity0 have Stage I disease. Conservative surgery is generally used in malignant germ cell @entity1 even in advanced stages. The relation between ovulation induction and @entity1 recurrence is not consistent in the literature. Spontaneous pregnancy rates following fertility saving surgery has been reported as 60-88%. Because of this over-treatment of these @entity0 for fertility should be avoided. Briefly, fertility saving surgery can be performed safely in germ cell, borderline and early @entity2 in selected cases. Any increment in the rate of @entity1 recurrence following ovulation induction has not yet been demonstrated. @entity4 caused by chemotherapy are transient. The @entity3 rate of @entity2 @entity0 is slightly higher than that of the normal population, but no significant difference has been observed between @entity0 who received or did not receive chemotherapy.

title: Oncologic and reproductive outcome after fertility-saving surgery in XXXX .

answer: @entity2


abstract: OBJECTIVE: To evaluate the appropriateness of the structure and the process of care for gynaecological @entity1 against national guidelines. SETTING _ SAMPLE: Incident cases of @entity2 managed between 1 January, 1999 and 31 December, 2000 in the South East of England. METHODS: Completion of an audit form, by a researcher, using the clinical record. Qualitative interviews with gynaecologists at each hospital. MAIN OUTCOME MEASURES: Whether hospitals meet the requirements for being a 'centre' or a 'unit' for gynaecological @entity1 and whether gynaecologists manage @entity2 according to the guidelines. RESULTS: Stage was recorded in the notes of 53% (262/492) of @entity0 with @entity2 but information to assist in determining stage was recorded in 86%. Of @entity0 who had a stage recorded by the consultant, who should have had a laparotomy and be referred for chemotherapy, 81% (169/209) were managed according to the guidelines, ignoring whether there was removal of disease to nodules of less than 1 cm. Stage was recorded in the notes of 60% (188/315) of @entity0 with @entity1 , although information relevant to staging the @entity0 was recorded in 66%. Overall 76% (142/188) of @entity0 with stage recorded in the notes were managed according to the guidelines but 40% (127/315) of @entity0 audited were not assessable. Only one site met the criteria for being a @entity1 centre. Of the remaining sites, most striking was the inability to assemble a team of professionals, including a radiologist, a pathologist and an oncology nurse to discuss individual @entity0 care. CONCLUSIONS: Retrospective note audits will be hampered by missing data in the clinical record until systems are developed to improve the quality of notes. This research suggests that guidelines based on FIGO staging for the @entity2 are not followed and that this may be associated with incomplete @entity1 management teams.

title: National guidance on gynaecological @entity1 management: an audit of gynaecological XXXX services and management in the South East of England.

answer: @entity1


abstract: OBJECTIVE: To evaluate the appropriateness of the structure and the process of care for gynaecological @entity1 against national guidelines. SETTING _ SAMPLE: Incident cases of @entity2 managed between 1 January, 1999 and 31 December, 2000 in the South East of England. METHODS: Completion of an audit form, by a researcher, using the clinical record. Qualitative interviews with gynaecologists at each hospital. MAIN OUTCOME MEASURES: Whether hospitals meet the requirements for being a 'centre' or a 'unit' for gynaecological @entity1 and whether gynaecologists manage @entity2 according to the guidelines. RESULTS: Stage was recorded in the notes of 53% (262/492) of @entity0 with @entity2 but information to assist in determining stage was recorded in 86%. Of @entity0 who had a stage recorded by the consultant, who should have had a laparotomy and be referred for chemotherapy, 81% (169/209) were managed according to the guidelines, ignoring whether there was removal of disease to nodules of less than 1 cm. Stage was recorded in the notes of 60% (188/315) of @entity0 with @entity1 , although information relevant to staging the @entity0 was recorded in 66%. Overall 76% (142/188) of @entity0 with stage recorded in the notes were managed according to the guidelines but 40% (127/315) of @entity0 audited were not assessable. Only one site met the criteria for being a @entity1 centre. Of the remaining sites, most striking was the inability to assemble a team of professionals, including a radiologist, a pathologist and an oncology nurse to discuss individual @entity0 care. CONCLUSIONS: Retrospective note audits will be hampered by missing data in the clinical record until systems are developed to improve the quality of notes. This research suggests that guidelines based on FIGO staging for the @entity2 are not followed and that this may be associated with incomplete @entity1 management teams.

title: National guidance on gynaecological XXXX management: an audit of gynaecological @entity1 services and management in the South East of England.

answer: @entity1


abstract: The efficacy of a combination of @entity5 and @entity7 in @entity0 with metastatic and recurrent @entity2 , was tested. Thirty @entity0 were included in the study. Initially, 27 @entity0 (90%) had received pelvic radiation and intracavitary boost and one @entity0 was additionally given paraaortic radiation. @entity7 was given at 75 mg/m2 followed by @entity5 at 750 mg/m2 on day 1 with three weekly intervals for a maximum of six cycles. All @entity0 received a median of four cycles of chemotherapy. The overall response rate for all eligible @entity0 was 20% (continuous @entity9 , PR: 4 @entity0 ). Overall response rate and progressive response in @entity0 with relapse within the previous radiation field were 9.5% and 66.7%, respectively; while for @entity0 who had recurrent disease outside any irradiated area both were 44.4%. Eighteen @entity0 (60%) had early withdrawal from the planned schedule, which was due to @entity0 incompliance in seven @entity0 (23.3%), disease progression in ten (33.3%) and @entity3 after the first cycle in one @entity0 (3.3%). @entity4 was the most frequent @entity1 , necessiating 24 transfusions in nine @entity0 (30%). WHO grade 3 and 4 @entity1 were @entity4 : 13 (43.3%), @entity8 : one (3.3%), @entity6 : two (6.6%), renal: one, emesis: nine (30.0%) @entity0 . The median survival duration for all eligible @entity0 was 11 months. Univariate analysis revealed that progressive response to chemotherapy was the only prognostic factor for survival (7.1 vs 16.8 months, p = 0.003). The combination of @entity7 and @entity5 did not appear to be more active than single agent @entity7 in this @entity0 group with a relatively poor prognosis. Further studies are required to determine a better therapeutic approach for @entity0 with relapsed @entity2 .

title: Efficacy of XXXX and @entity5 combination for recurrent and metastatic carcinoma of the uterine cervix.

answer: @entity7


abstract: The efficacy of a combination of @entity5 and @entity7 in @entity0 with metastatic and recurrent @entity2 , was tested. Thirty @entity0 were included in the study. Initially, 27 @entity0 (90%) had received pelvic radiation and intracavitary boost and one @entity0 was additionally given paraaortic radiation. @entity7 was given at 75 mg/m2 followed by @entity5 at 750 mg/m2 on day 1 with three weekly intervals for a maximum of six cycles. All @entity0 received a median of four cycles of chemotherapy. The overall response rate for all eligible @entity0 was 20% (continuous @entity9 , PR: 4 @entity0 ). Overall response rate and progressive response in @entity0 with relapse within the previous radiation field were 9.5% and 66.7%, respectively; while for @entity0 who had recurrent disease outside any irradiated area both were 44.4%. Eighteen @entity0 (60%) had early withdrawal from the planned schedule, which was due to @entity0 incompliance in seven @entity0 (23.3%), disease progression in ten (33.3%) and @entity3 after the first cycle in one @entity0 (3.3%). @entity4 was the most frequent @entity1 , necessiating 24 transfusions in nine @entity0 (30%). WHO grade 3 and 4 @entity1 were @entity4 : 13 (43.3%), @entity8 : one (3.3%), @entity6 : two (6.6%), renal: one, emesis: nine (30.0%) @entity0 . The median survival duration for all eligible @entity0 was 11 months. Univariate analysis revealed that progressive response to chemotherapy was the only prognostic factor for survival (7.1 vs 16.8 months, p = 0.003). The combination of @entity7 and @entity5 did not appear to be more active than single agent @entity7 in this @entity0 group with a relatively poor prognosis. Further studies are required to determine a better therapeutic approach for @entity0 with relapsed @entity2 .

title: Efficacy of @entity7 and XXXX combination for recurrent and metastatic carcinoma of the uterine cervix.

answer: @entity5


abstract: BACKGROUND AND PURPOSE: Endothelial progenitor cells (EPC) are important @entity0 of @entity6 and are mobilized through signaling with stromal-derived factor (SDF-1a), @entity1 ( @entity1 ), @entity9 . The association between EPC levels and these growth factors (GF) in @entity2 has not been previously established. We aimed to determine the association between EPC and these GF, and to elucidate a relationship between these GF and @entity2 severity in @entity2 @entity0 . METHODS: Seventeen @entity0 were selected from 175 @entity0 with imaging-confirmed acute @entity4 . EPC were quantified using @entity5 , @entity7 , and @entity3 markers. Plasma @entity1 , SDF-1a, @entity9 were determined by enzyme-linked immunosorbent assay on days 1 and 3, and brain MRI was performed at baseline and on days 1 and 5 after the @entity2 onset. RESULTS: Levels of SDF-1a strongly (r=0.6) correlated with the numbers of EPC subsets @entity7 (+)VEFG-R2(+) (P<0.004), @entity5 (+) @entity1 -R2(+) (P<0.01), and @entity5 (+) @entity7 (+) @entity1 -R2(+) (P<0.01) on day 1. @entity8 strongly (r=0.5) correlated with @entity7 (+) @entity1 -R2(+) (P<0.05). SDF-1a moderately inversely (r=-0.49) correlated with baseline diffusion-weighted imaging lesion volumes (P<0.04). Median levels of SDF-1a (1561 pg/mL) increased (P<0.04) on day 3 compared to day 1 (1379 pg/mL). Similarly, @entity1 at day 3 (95 pg/mL) increased (P<0.03) compared to day 1 (64 pg/mL). CONCLUSIONS: These results indicate that SDF-1a and @entity8 correlate with an increase in EPC early in @entity4 @entity0 .

title: Stromal-derived factor-1[alpha] correlates with circulating endothelial progenitor cells and with acute lesion volume in XXXX @entity0 .

answer: @entity2


abstract: BACKGROUND AND PURPOSE: Endothelial progenitor cells (EPC) are important @entity0 of @entity6 and are mobilized through signaling with stromal-derived factor (SDF-1a), @entity1 ( @entity1 ), @entity9 . The association between EPC levels and these growth factors (GF) in @entity2 has not been previously established. We aimed to determine the association between EPC and these GF, and to elucidate a relationship between these GF and @entity2 severity in @entity2 @entity0 . METHODS: Seventeen @entity0 were selected from 175 @entity0 with imaging-confirmed acute @entity4 . EPC were quantified using @entity5 , @entity7 , and @entity3 markers. Plasma @entity1 , SDF-1a, @entity9 were determined by enzyme-linked immunosorbent assay on days 1 and 3, and brain MRI was performed at baseline and on days 1 and 5 after the @entity2 onset. RESULTS: Levels of SDF-1a strongly (r=0.6) correlated with the numbers of EPC subsets @entity7 (+)VEFG-R2(+) (P<0.004), @entity5 (+) @entity1 -R2(+) (P<0.01), and @entity5 (+) @entity7 (+) @entity1 -R2(+) (P<0.01) on day 1. @entity8 strongly (r=0.5) correlated with @entity7 (+) @entity1 -R2(+) (P<0.05). SDF-1a moderately inversely (r=-0.49) correlated with baseline diffusion-weighted imaging lesion volumes (P<0.04). Median levels of SDF-1a (1561 pg/mL) increased (P<0.04) on day 3 compared to day 1 (1379 pg/mL). Similarly, @entity1 at day 3 (95 pg/mL) increased (P<0.03) compared to day 1 (64 pg/mL). CONCLUSIONS: These results indicate that SDF-1a and @entity8 correlate with an increase in EPC early in @entity4 @entity0 .

title: Stromal-derived factor-1[alpha] correlates with circulating endothelial progenitor cells and with acute lesion volume in @entity2 XXXX .

answer: @entity0


abstract: OBJECTIVE: To observe the effect of electroacupuncture (EA) on force-displacement value ( @entity4 ) of muscle state and the temperature index of infrared thermogram in @entity0 with @entity1 . METHODS: @entity0 with @entity1 were randomly divided into a medication group and an EA group. The medication group (n = 60) were treated with @entity3 dual release enteric-coated capsules, 75 mg per day for 7 days. The EA group (n = 60) received EA at bilateral Houxi (SI 3), Jiaji (EX-B2), and Ashi points, at 20-30 mm depth and 10-25 Hz frequency for 20 min daily for 7 days. Muscle states were determined by measuring FDVs of the bilateral lumbar muscle with a Myotonometer fast muscle state detector. The temperature index of the lumbar skin was measured before and after treatment with a Fluke Ti30 non-refrigerated focal plane infrared thermal imaging detector. RESULTS: There were no significant pre-treatment differences between the medication group and the EA group in mean @entity4 (P = 0.052) or temperature index of the lumbar skin (P = 0.25). The cure rate was 63.3% in the EA group and 53.3% in the medication group. The total efficacy in the EA group (93.3 %) was not significantly different from that in the medication group (86.6 %, P = 0.204). After treatment, the mean @entity4 of the lumbar muscle significantly increased in both groups (P < 0.05 for both groups); the @entity4 increase in the EA group was significantly higher than in the medication group (P = 0.015). The temperature index was also significantly increased in both groups (P < 0.05 for both groups); the infrared thermogram in the EA group indicated significantly greater recovery compared to the medication group (P = 0.026). CONCLUSION: Both EA and @entity3 markedly improved @entity2 , but EA better improved the rehabilitation and regeneration of FDVs and temperature index of infrared thermogram of the muscle.

title: Effect of electroacupuncture on muscle state and infrared thermogram changes in @entity0 with XXXX .

answer: @entity1


abstract: OBJECTIVE: To observe the effect of electroacupuncture (EA) on force-displacement value ( @entity4 ) of muscle state and the temperature index of infrared thermogram in @entity0 with @entity1 . METHODS: @entity0 with @entity1 were randomly divided into a medication group and an EA group. The medication group (n = 60) were treated with @entity3 dual release enteric-coated capsules, 75 mg per day for 7 days. The EA group (n = 60) received EA at bilateral Houxi (SI 3), Jiaji (EX-B2), and Ashi points, at 20-30 mm depth and 10-25 Hz frequency for 20 min daily for 7 days. Muscle states were determined by measuring FDVs of the bilateral lumbar muscle with a Myotonometer fast muscle state detector. The temperature index of the lumbar skin was measured before and after treatment with a Fluke Ti30 non-refrigerated focal plane infrared thermal imaging detector. RESULTS: There were no significant pre-treatment differences between the medication group and the EA group in mean @entity4 (P = 0.052) or temperature index of the lumbar skin (P = 0.25). The cure rate was 63.3% in the EA group and 53.3% in the medication group. The total efficacy in the EA group (93.3 %) was not significantly different from that in the medication group (86.6 %, P = 0.204). After treatment, the mean @entity4 of the lumbar muscle significantly increased in both groups (P < 0.05 for both groups); the @entity4 increase in the EA group was significantly higher than in the medication group (P = 0.015). The temperature index was also significantly increased in both groups (P < 0.05 for both groups); the infrared thermogram in the EA group indicated significantly greater recovery compared to the medication group (P = 0.026). CONCLUSION: Both EA and @entity3 markedly improved @entity2 , but EA better improved the rehabilitation and regeneration of FDVs and temperature index of infrared thermogram of the muscle.

title: Effect of electroacupuncture on muscle state and infrared thermogram changes in XXXX with @entity1 .

answer: @entity0