abstract: UNASSIGNED: Considerable evidence demonstrates that @entity2 are prevalent in @entity4 during both acute @entity9 and euthymia. However, it is less clear whether these cognitive disturbances are state- or trait-related. We here present the first longitudinal study employing a within-subject pre- and post-testing examining acutely admitted bipolar @entity0 (BP) in @entity5 or @entity4 and during euthymia, aiming to identify cognitive performance from acute illness to remission. Cognitive performance was measured during acute @entity9 and repeated after at least 3  months of remission. To do so, 55 BP (35 @entity5 , 20 hypo-/ @entity4 ) and 55 healthy controls (HC) were tested with a neuropsychological test battery (attention, working memory, verbal memory, executive functioning). The results showed @entity3 in acutely ill BP compared to HC: @entity5 @entity0 showed a characteristic @entity7 , while @entity4 @entity0 had severe deficits in executive functioning. Twenty-nine remitted BP could be measured in the follow-up (dropout rate 48  %), whose cognitive functions partially recovered, whereas working @entity8 were still impaired. However, we found that subthreshold @entity5 and persisting @entity1 in euthymic BP were associated with reduced speed, @entity8 , while working memory was correlated with @entity6 (lifetime). This result indicates working memory as trait related for a subgroup of BP with @entity6 . In contrast, attention and verbal memory are negatively influenced by state factors like residual symptoms, which should be more considered as possible confounders in the search of cognitive endophenotypes in remitted BP.

title: XXXX in @entity4 : from acute episode to remission.

answer: @entity3


abstract: INTRODUCTION: Laparoscopic (LAP) colectomy is now the "gold" standard for @entity1 ; the role of @entity2 ( @entity2 ) and Open methods today is unclear. This study assessed the elective use of these methods for @entity1 . METHODS: A retrospective review of demographic, comorbidity (Carlson Comorbidity Index [CCI]), resection type, and short-term outcomes was carried out. RESULTS: There were 125 (44.5%) LAP, 125 (44.5%) @entity2 , and 31 (11%) Open cases (overall N = 281). The mean age, body mass index, and percentage of high-risk @entity0 (CCI score >2) of the @entity2 group were greater (P < .05) than the LAP group (vs Open, P = ns). The Open group's mean age and percent with CCI >2 was greater when compared with the LAP group (P < .05). More Open (P < .05) and @entity2 @entity0 had complex disease (Open, 63%; @entity2 , 40%, LAP, 22%) and were diverted (Open, 35%; @entity2 , 10%; LAP, 3%). Time to bowel movement was not different; however, there was a stepwise increase in median length of stay (LOS; days) from the LAP (5 days) to @entity2 (6 days) to Open group (7 days) (P < .05 for all). The LAP complication rate (22.4%) was lower (P < .05) than the @entity2 (42.4%) or Open groups' (45.2%) rates. The LAP surgical site infection rate (5.6%) was lower (P < .05) than the @entity2 (12.8%) or Open groups (19.6%). CONCLUSION: The @entity2 and Open groups had more high risk, complex disease, diverted, and older @entity0 than the LAP group; likewise, the overall complication rate and LOS was higher in the @entity2 and Open groups. Use of @entity2 methods likely contributed to the high minimally invasive surgery utilization rate (89%).

title: Surgical Treatment of XXXX : Hand-Assisted Laparoscopic Resection Is Predominantly Used for Complex Cases and Is Associated With Increased Postoperative Complications and Prolonged Hospitalization.

answer: @entity1


abstract: A series of 24 consecutive @entity0 with @entity4 of the tibia and soft tissue defects were treated according to the principle of radical excision of the infected bone together with transposition of @entity1 and primary skin cover as a one-stage procedure. External fixation was used for stabilization of bone. The mean duration of @entity4 before radical operation was 72 weeks and the previous stay in hospital averaged 15 weeks. Twenty-one @entity0 had previously undergone 3.7 operations because of the @entity2 . @entity3 was cultured in 50% of the @entity0 , while no bacteria could be identified in six patients. Appropriate antibiotics were given for an average of eight weeks. In four @entity0 a secondary bone transplant and in three @entity0 another skin transplant was necessary. One @entity0 refusing further reconstructive surgery insisted on an above-knee amputation because of persisting @entity2 . After an average observation time of 2 1/2 years no @entity2 or instability of the tibia could be demonstrated, but one @entity0 showed two small skin defects. These results indicate that radical excision of infected bone in combination with muscle transposition and primary skin cover is effective in the treatment of posttraumatic @entity4 of the tibia.

title: Muscle transposition for treatment of XXXX of the tibia.

answer: @entity4


abstract: The following summary of the physiologic and epidemiologic evidence may help the clinician in making decisions when caring for @entity0 with ISH: ISH is predominantly found in older age groups, being present in 1% to 4% of the population under age 40, 10% to 15% between ages 60 and 70, and 25% to 30% over age 70. ISH is more prevalent in @entity0 than in @entity0 . The development of ISH in the aged is associated with a decrease in arterial compliance. The relationship whereby ISH is both a cause and a result of @entity4 vessels needs further delineation. Neurohumoral factors also have a part in determining arterial compliance. An elevated @entity5 is an important contributor to the risk of developing @entity3 , and in @entity0 over 45 years old it is a more powerful predictor of coronary events than @entity6 . @entity5 is a better discriminator of risk for @entity1 at all ages than @entity6 is. The relative risk in @entity0 with ISH for the development of @entity3 and @entity1 is two to five times that of normotensive @entity0 , but is no worse than the risk for these events among treated @entity2 . Although the relative risk of ISH is not strikingly large, the high prevalence of ISH among aged individuals, the increasing size of the population over 65 years old, and the high incidence rate of cardiovascular events in the aged give ISH a sizable attributable risk in the population (13 to 28 deaths per 1,000 individuals). It remains to be shown that lowering @entity5 in ISH removes the risk of ISH. Studies are needed that monitor the costs and adverse effects of therapy as well as the possible benefits when a condition such as ISH is most commonly seen in the aged.

title: Isolated systolic XXXX : how common? How risky?

answer: @entity2


abstract: BACKGROUND: Phytobezoars are a rare cause of @entity1 . The aim of this work was to identify the diagnostic difficulties and treatment of this rare entity. METHODS: Data of 14 @entity0 operated between January 1999-January 2009 with small bowel phytobezoar were retrospectively studied. The @entity0 (n=432) were treated in our clinic for @entity2 . Of these, 14 (3.2%) phytobezoar-induced @entity2 were included in this series. Median @entity0 age was 57.25 years; nine (64%) of the @entity0 were male, and five (36%) were female. RESULTS: The predisposing factor was previous gastric surgery in 12 (87.5%) @entity0 and previous abdominal surgery and total absence of the teeth in two (14.3%) @entity0 . A completely obstructing @entity3 was found in nine (64%) @entity0 and @entity4 in five (36%) @entity0 during exploration. There was no mortality. CONCLUSION: Phytobezoar-induced @entity2 remains an uncommon diagnosis that poses a diagnostic and management challenge. It should be suspected in @entity0 with an increased risk of bezoar formation, such as in the presence of previous gastric surgery, poor dentition or a history suggestive of increased fiber intake.

title: A rare cause of acute abdomen: XXXX due to phytobezoar.

answer: @entity2


abstract: BACKGROUND: Fall from height is one of the important causes of @entity1 . Fall from walnut trees constitutes an important entity that leads to a significant mortality and morbidity amongst those engaged in fruit collection. The present study aimed to determine the prevalence of different @entity1 in these victims and to highlight the importance of recognizing this incident as an @entity5 . METHODS: A retrospective study of all @entity0 admitted to the Orthopedic Department of the Sher-i-Kashmir Institute of Medical Sciences (SKIMS) Medical College from January 2003 to December 2007 was conducted. The medical records were studied for the different types of @entity2 , associated @entity2 and delay in the referral of @entity0 . RESULTS: 94% of falls occurred from August to October. Of the 115 @entity0 , 63 (54.7%) had associated non-orthopedic @entity2 . @entity4 was the most common associated injury, presenting in 34 @entity0 (29.5%). Thoracolumbar (16.5%), calcaneum (10.5%) and distal radius (8.7%) @entity3 constituted the common @entity3 encountered in the victims. CONCLUSION: Walnut tree @entity2 mostly involve young males who form the productive group of the population. Being a seasonal injury, it puts a considerable load on the health resources of the region over a small period of time.

title: Walnut tree falls as a cause of XXXX --a study from a tertiary care center in Kashmir.

answer: @entity1


abstract: Trypanosome stocks isolated from bats (Chiroptera) and belonging to the subgenus Schizotrypanum were analyzed by multilocus enzyme electrophoresis (MLEE) at 22 loci, random amplified polymorphic DNA (RAPD) with 14 primers and/or cytochrome b @entity0 sequence. Bat trypanosomes belonged to the species @entity2 marinkellei (10 stocks), @entity2 dionisii (four stocks) and @entity2 vespertilionis (three stocks). One T. rangeli stock and seven stocks of @entity2 sensu stricto, the agent of @entity1 , were included for comparison. The homology of several RAPD fragments shared by distinct species was verified by hybridization. The sequence of a 516- @entity0 portion of the maxicircle-encoded cytochrome b (CYb) coding region was determined in representative stocks of the species under study. Phylogenetic analysis of the data confirmed the previous taxonomic attribution of these bat trypanosomes based on biological, epidemiological and ecological features. However, a new finding was that within @entity2 marinkellei two major subdivisions could be distinguished, T.c.m. I, found in the spear-nose bats Phyllostomus discolor and Phyllostomus hastatus, and T.c.m. II, from P. discolor. In addition, the T. c. marinkellei 'Z' stock from a short-tailed bat (Carollia perspicillata) was distantly related to these two subdivisions, and the monophyly of T. c. marinkellei is unclear based on the present data. Based on the present sample, the European species T. dionisii and T. vespertilionis appeared to be more homogeneous. RAPD and CYb data both suggested the monophyly of a group composed of @entity2 and the two major subdivisions of @entity2 marinkellei. This study shows that MLEE, RAPD and CYb can be used for taxonomic assignment and provide valuable phylogenetic information for strains and taxa within the subgenus Schizotrypanum. An evolutionary scenario in which the broad host-range parasite @entity2 would be derived from a bat-restricted trypanosome ancestor is discussed.

title: Phylogenetic diversity of bat trypanosomes of subgenus Schizotrypanum based on multilocus enzyme electrophoresis, random amplified polymorphic DNA, and cytochrome b XXXX sequence analyses.

answer: @entity0


abstract: Therapy-related @entity1 (t-MNs) are serious long-term consequences of cytotoxic treatments for an antecedent disorder. t-MNs are observed after ionizing radiation as well as conventional chemotherapy including alkylating agents, topoisomerase-II-inhibitors and antimetabolites. In addition, adjuvant use of recombinant @entity0 @entity3 may also increase the risk of t-MNs. There is clinical and biological overlap between t-MNs and high-risk de novo @entity4 and @entity5 suggesting similar mechanisms of leukaemogenesis. @entity0 studies and animal models point to a prominent role of genetic susceptibilty in the pathogenesis of t-MNs. Common genetic variants have been identified that modulate t-MN risk, and t-MNs have been observed in some @entity1 . In either case, establishing a leukaemic phenotype requires acquisition of somatic mutations - most likely induced by the cytotoxic treatment. Knowledge of the specific nature of the initiating exposure has allowed the identification of crucial pathogenetic mechanisms and for these to be modelled in vitro and in vivo. Prognosis of @entity0 with t-MNs is dismal and at present, the only curative approach for the majority of these individuals is haematopoietic stem cell transplantation, which is characterized by high transplant-related mortality rates. Novel transplantation strategies using reduced intensity conditioning regimens as well as novel drugs - demethylating agents and targeted therapies - await clinical testing and may improve outcome. Ultimately, individual assessment of genetic risk factors may translate into tailored therapies and establish a strategy for reducing t-MN incidences without jeopardizing therapeutic success rates for the @entity2 .

title: Therapy-related XXXX : pathobiology and clinical characteristics.

answer: @entity1


abstract: BACKGROUND: A polymethylmethacrylate-collagen filler is generally believed to give long-term benefits, but the risk of @entity1 formation over time remains unclear. OBJECTIVE: To determine the incidence of @entity1 formation and response to treatment and assess the degree of @entity0 satisfaction over 5 years. MATERIALS AND METHODS: Adults seeking correction of nasolabial folds underwent up to 3 injection sessions over 2 months. Subjects were then queried regularly for the development of signs and symptoms of a @entity1 . Any positive responses were evaluated, and lesions suspicious for @entity1 were confirmed by biopsy. @entity1 were treated at the discretion of the investigator. Subjects also completed regular satisfaction questionnaires. RESULTS: A total of 1,008 subjects were enrolled and 871 completed the full 5 years of the study. A biopsy-confirmed @entity1 developed in 1.7% of subjects. Almost all @entity1 responded to treatment. At study exit, 0.9% of subjects had an unresolved @entity1 . @entity0 satisfaction remained high throughout the duration of the study. CONCLUSION: The incidence of @entity1 formation with a polymethylmethacrylate-collagen dermal filler is low, and almost all lesions are manageable with simple therapeutic measures. @entity0 satisfaction remains durable over 5 years. @entity2 -collagen offers a well-characterized and very favorable risk/benefit profile.

title: Five-Year Safety and Satisfaction Study of XXXX -Collagen in the Correction of Nasolabial Folds.

answer: @entity2


abstract: Importance: Intracranial @entity8 ( @entity9 ) may coexist. There are limited data on the frequency and risk factors for coexistent @entity9 and the effect of @entity9 on @entity3 recurrence in @entity0 receiving medical treatment for ICAS. Objective: To investigate the frequency and risk factors for @entity9 and the effect of @entity9 on @entity3 recurrence in @entity0 with ICAS. Design, Setting, and @entity0 : A post hoc analysis of the Stenting and Aggressive Medical Management for Preventing Recurrent @entity3 (SAMMPRIS) study, a prospective, multicenter clinical trial. Among 451 @entity0 , 313 (69.4%) had baseline brain magnetic resonance imaging scans read centrally for @entity9 that was defined by any of the following: old @entity7 , grade 2 to 3 on the Fazekas scale (for high-grade @entity2 ), or microbleeds. @entity0 enrollment in SAMMPRIS began November 25, 2008, and follow-up ended on April 30, 2013. Data analysis for the present study was performed from May 13, 2014, to July 29, 2015. Main Outcomes and Measures: Risk factors in @entity0 with vs without @entity9 and the association between @entity9 and other baseline risk factors with any @entity4 and @entity4 in the territory of the stenotic artery determined using proportional hazards regression. Results: Of 313 @entity0 , 155 individuals (49.5%) had @entity9 noted on baseline magnetic resonance imaging. Variables that were significantly higher in @entity0 with @entity9 , reported as mean (SD), included age, 63.5 (10.5) years (P   <   .001), systolic blood pressure, 149 (22) mm Hg (P   <   .001), @entity5 level, 130 (50) mg/dL (P   =   .03), and lower Montreal Cognitive Assessment scores (median, >= 24 [interquartile range, 20-26]; P   =   .02).Other significant variables were the number of @entity0 with @entity1 (88 of 155 [56.8%]; P   =   .003), @entity6 (46 [29.7%]; P   =   .004), @entity3 before the qualifying event (59 [38.1%]; P   <   .001), old @entity7 in the territory of the stenotic intracranial artery (88 [56.8%]; P   <   .001), and receiving antithrombotic therapy at the time of the qualifying event (109 [70.3%]; P   =   .005). The association between @entity9 and any @entity4 was nearly significant in the direction of a higher risk (18 [23.7%]); P   =   .07) for @entity0 with @entity9 . On bivariate analysis, @entity9 was not associated with an increased risk on multivariable analyses (hazard ratio, 1.7 [95% CI, 0.8-3.8]; P   =   .20). In addition, @entity9 was not associated with an increased risk of @entity3 in the territory on either bivariate or multivariable analyses. Conclusions and Relevance: Although @entity9 is common in @entity0 with ICAS, the presence of @entity9 on baseline magnetic resonance imaging is not independently associated with an increased risk of @entity3 in @entity0 with ICAS. Trial Registration: clinicaltrials.gov Identifier: NCT00576693.

title: Frequency, Risk Factors, and Outcome of Coexistent Small Vessel Disease and Intracranial @entity8 : Results From the Stenting and Aggressive Medical Management for Preventing Recurrent XXXX (SAMMPRIS) Trial.

answer: @entity3


abstract: Importance: Intracranial @entity8 ( @entity9 ) may coexist. There are limited data on the frequency and risk factors for coexistent @entity9 and the effect of @entity9 on @entity3 recurrence in @entity0 receiving medical treatment for ICAS. Objective: To investigate the frequency and risk factors for @entity9 and the effect of @entity9 on @entity3 recurrence in @entity0 with ICAS. Design, Setting, and @entity0 : A post hoc analysis of the Stenting and Aggressive Medical Management for Preventing Recurrent @entity3 (SAMMPRIS) study, a prospective, multicenter clinical trial. Among 451 @entity0 , 313 (69.4%) had baseline brain magnetic resonance imaging scans read centrally for @entity9 that was defined by any of the following: old @entity7 , grade 2 to 3 on the Fazekas scale (for high-grade @entity2 ), or microbleeds. @entity0 enrollment in SAMMPRIS began November 25, 2008, and follow-up ended on April 30, 2013. Data analysis for the present study was performed from May 13, 2014, to July 29, 2015. Main Outcomes and Measures: Risk factors in @entity0 with vs without @entity9 and the association between @entity9 and other baseline risk factors with any @entity4 and @entity4 in the territory of the stenotic artery determined using proportional hazards regression. Results: Of 313 @entity0 , 155 individuals (49.5%) had @entity9 noted on baseline magnetic resonance imaging. Variables that were significantly higher in @entity0 with @entity9 , reported as mean (SD), included age, 63.5 (10.5) years (P   <   .001), systolic blood pressure, 149 (22) mm Hg (P   <   .001), @entity5 level, 130 (50) mg/dL (P   =   .03), and lower Montreal Cognitive Assessment scores (median, >= 24 [interquartile range, 20-26]; P   =   .02).Other significant variables were the number of @entity0 with @entity1 (88 of 155 [56.8%]; P   =   .003), @entity6 (46 [29.7%]; P   =   .004), @entity3 before the qualifying event (59 [38.1%]; P   <   .001), old @entity7 in the territory of the stenotic intracranial artery (88 [56.8%]; P   <   .001), and receiving antithrombotic therapy at the time of the qualifying event (109 [70.3%]; P   =   .005). The association between @entity9 and any @entity4 was nearly significant in the direction of a higher risk (18 [23.7%]); P   =   .07) for @entity0 with @entity9 . On bivariate analysis, @entity9 was not associated with an increased risk on multivariable analyses (hazard ratio, 1.7 [95% CI, 0.8-3.8]; P   =   .20). In addition, @entity9 was not associated with an increased risk of @entity3 in the territory on either bivariate or multivariable analyses. Conclusions and Relevance: Although @entity9 is common in @entity0 with ICAS, the presence of @entity9 on baseline magnetic resonance imaging is not independently associated with an increased risk of @entity3 in @entity0 with ICAS. Trial Registration: clinicaltrials.gov Identifier: NCT00576693.

title: Frequency, Risk Factors, and Outcome of Coexistent Small Vessel Disease and Intracranial XXXX : Results From the Stenting and Aggressive Medical Management for Preventing Recurrent @entity3 (SAMMPRIS) Trial.

answer: @entity8


abstract: BACKGROUND: Differentiation of some @entity5 ( @entity4 ) lesions is a challenge. @entity3 ( @entity3 ) has been proved to be useful in the diagnosis of @entity2 ; however, to date, there is no report on the differential study of the two diseases with @entity3 . OBJECTIVES: To obtain the @entity3 image characteristics of SK and @entity4 , and then test the differential ability of @entity3 imaging. METHODS: We recruited 10 @entity0 with typical lesions of SK under @entity3 images to validate the features reported. Another 10 @entity0 with typical @entity1 were also recruited, imaged with @entity3 and biopsied to obtain the features under @entity3 images based on histology analysis. Then, we attempt to summarize and refine those characteristics collected to obtain the most significant ones. All the cases with lesions suggestive of SK or @entity4 were advised to undergo imaging with @entity3 , and if @entity3 imaging reflected discordantly with the clinical diagnosis, a biopsy was suggested for the exact lesion imaged. Those cases with @entity3 and histology results were collected. Finally, two clinical dermatologists, who had no previous experience with @entity3 , were tested with the simplified features of @entity3 images to differentiate the suspected lesions of SK and @entity4 among the cases collected. RESULTS: In total, there were 58 cases with @entity3 images and histology results collected, in which, 40 cases were diagnosed as SK and 18 cases as @entity4 by histology. The two blinded dermatologists' judgments were identical to histology analysis. CONCLUSION: @entity3 proved to be valuable in the differential diagnosis of SK and @entity4 . The simplified characteristics were easily understood and acceptable to those with no previous experience of @entity3 .

title: XXXX ? A pilot study with confocal laser scanning microscopy.

answer: @entity5


abstract: We investigated the influence of agricultural management and various plant covers related to the period of abandonment on soil properties, @entity2 and nutrient depletion in a typical Mediterranean area with sandy loam shallow soils. Cultivated soils (CS) with insufficient management, 5 year abandoned soils covered with meadow (A5), 25 year abandoned soils covered with dense scrubs (A25), 50 year abandoned soils covered with cork trees (A50) and soils in a 50 year pine reforested area (P50) were studied over a period of 6 months (May-October 1999). The soils were classified as Lithic Xerorthents. Both the differences in soil properties and response to rainfall events were mainly attributed to the different vegetation types and stages in land management. Principal components analysis (PCA) was performed on the results, by running the overall data determined after five rainfall events. The factors extracted by PCA of the samples by variables matrix represented the response of the environments to different rainfall intensities as a function of management or natural evolution after abandonment. CS environments showed the highest runoff and sediment yield as well as the highest amount of dissolved organic @entity0 ( @entity3 ) and @entity1 in runoff water. The sequence of abandonment (A5, A25 and A50) showed approximately the same runoff production, whereas eroded sediments (ES) and @entity3 were inversely correlated. Organic @entity0 in the ES and @entity3 in runoff water always increased with the period of abandonment, which accounted for consistent nutrient depletion. Nevertheless, the A50 environment (dominated by Quercus suber) showed the best soil properties, whilst the A25 environment with dense cover of Cistus monspeliensis and Calicotome espinosa seemed to cause a worsening effect on the soil's physical and chemical properties. This is probably because these environments are more severely damaged by wild fire occurrence. In terms of sediment yield, the P50 environment followed CS environment, indicating that reforestation followed by insufficient forest management may negatively affect both soil properties and response to the erosive action of rainfall.

title: XXXX and nutrient depletion in five Mediterranean soils of NE Spain under different land use.

answer: @entity2


abstract: UNASSIGNED: Treatment with helminthes and helminthes ova, improved clinical symptoms of several @entity8 in @entity0 and in animal models. @entity12 (PC) was proven to be the immunomodulatory molecule. We aimed to decipher the tolerogenic potential of @entity16 ( @entity16 ), a novel helminth based compound in @entity10 ( @entity10 ) in a @entity1 model of @entity2 ( @entity2 ). @entity10 DBA @entity1 were treated with @entity16 , subcutaneously (5  g/0.1ml) or orally (250  g/0.1ml), starting prior to disease induction. The control groups were treated with PBS. Collagen antibodies were tested by ELISA, cytokines protein levels by ELISA kits and T-regulatory (Treg) and B-regulatory (Breg) cells phenotypes by @entity15 . @entity16 treated @entity1 had a significant lower @entity3 score 1.5 in comparison with control @entity1 11.8 (p<0.0001) both in subcutaneous and orally treated groups at Day 31. Moreover, histology analysis demonstrated highly inflamed joints in control @entity1 , whereas @entity16 treated @entity1 maintained normal joint structure. Furthermore, @entity16 decreased the titers of circulating collagen II antibodies in @entity1 sera (p<0.0001), enhanced expression of @entity9 (p<0.0001), and inhibited production of @entity6 , @entity5 and @entity4 (p<0.0001). @entity16 significantly expanded the @entity11 (   +) CD25(+)    @entity13 (+   ) Treg cells and @entity14 (high) @entity7 (high) @entity17 (+) Breg cells phenotypes (p<0.0001) in treated @entity1 . Our data indicate that treatment with @entity16 attenuates @entity10 in @entity1 demonstrated by low arthritic score, and normal joints histology. @entity16 treatment reduced pro-inflammatory cytokines and increased anti-inflammatory cytokine expression, as well as expansion of Treg and Breg cells. Our results may lead to a new approach for a natural therapy for early @entity2 onset. This article is protected by copyright. All rights reserved.

title: Novel therapeutic compound tuftsin- XXXX attenuate @entity10 .

answer: @entity12


abstract: UNASSIGNED: Treatment with helminthes and helminthes ova, improved clinical symptoms of several @entity8 in @entity0 and in animal models. @entity12 (PC) was proven to be the immunomodulatory molecule. We aimed to decipher the tolerogenic potential of @entity16 ( @entity16 ), a novel helminth based compound in @entity10 ( @entity10 ) in a @entity1 model of @entity2 ( @entity2 ). @entity10 DBA @entity1 were treated with @entity16 , subcutaneously (5  g/0.1ml) or orally (250  g/0.1ml), starting prior to disease induction. The control groups were treated with PBS. Collagen antibodies were tested by ELISA, cytokines protein levels by ELISA kits and T-regulatory (Treg) and B-regulatory (Breg) cells phenotypes by @entity15 . @entity16 treated @entity1 had a significant lower @entity3 score 1.5 in comparison with control @entity1 11.8 (p<0.0001) both in subcutaneous and orally treated groups at Day 31. Moreover, histology analysis demonstrated highly inflamed joints in control @entity1 , whereas @entity16 treated @entity1 maintained normal joint structure. Furthermore, @entity16 decreased the titers of circulating collagen II antibodies in @entity1 sera (p<0.0001), enhanced expression of @entity9 (p<0.0001), and inhibited production of @entity6 , @entity5 and @entity4 (p<0.0001). @entity16 significantly expanded the @entity11 (   +) CD25(+)    @entity13 (+   ) Treg cells and @entity14 (high) @entity7 (high) @entity17 (+) Breg cells phenotypes (p<0.0001) in treated @entity1 . Our data indicate that treatment with @entity16 attenuates @entity10 in @entity1 demonstrated by low arthritic score, and normal joints histology. @entity16 treatment reduced pro-inflammatory cytokines and increased anti-inflammatory cytokine expression, as well as expansion of Treg and Breg cells. Our results may lead to a new approach for a natural therapy for early @entity2 onset. This article is protected by copyright. All rights reserved.

title: Novel therapeutic compound tuftsin- @entity12 attenuate XXXX .

answer: @entity10


abstract: @entity5 , originally identified as a calmodulin-dependent phosphoprotein phosphatase (Stewart, A.A. et al. (1982) FEBS Lett. 137, 80-84) also uses @entity2 and @entity4 as substrates (Pallen, C.J. and Wang, J.H. (1983) J. Biol. Chem. 258, 8550-8553). We have surveyed a wide range of nonprotein phosphocompounds and found that several synthetic aryl phosphocompounds serve as calcineurin substrates. Among more than 20 naturally occurring phosphocompounds tested, only @entity3 possesses significant @entity5 substrate activity. The @entity3 phosphatase activity is dependent on @entity1 and @entity0 , is stimulated by calmodulin, and is inhibited by a monoclonal antibody to calcineurin, thus indicating that it is an intrinsic property of calcineurin. The results suggest that functional roles of calcineurin may include actions of the enzyme toward nonprotein phosphocompounds.

title: Survey of calcineurin activity towards nonprotein compounds and identification of XXXX as a substrate.

answer: @entity3


abstract: BACKGROUND: @entity3 ( @entity3 ) has recently been implicated as the primary cause of @entity1 ( @entity1 ). OBJECTIVE: The aim of this study was to determine the presence of @entity3 in @entity1 @entity0 . METHODS: We performed selective extracranial venography on 42 @entity0 with early @entity1 (EMS): @entity2 ( @entity2 ) or @entity5 ( @entity5 ) of less than 5 years duration, and @entity1 ( @entity1 ): @entity5 of more than 10 years duration. Magnetic resonance imaging (MRI) and clinical relapse data were reviewed for all @entity0 with @entity3 . RESULTS: @entity3 was present in 7/29 @entity0 with EMS and 12/13 @entity0 with @entity1 , a highly significant statistical difference (p< 0.001). Only 3/42 @entity0 (all in the @entity1 group) had two vessel stenoses, while the rest had only one vessel involved. @entity3 was seen in 1/11 @entity0 with @entity2 compared with 6/18 @entity5 @entity0 of less than 5 years duration. Disease duration was greater in @entity0 with @entity3 overall (p < 0.005). @entity1 remained an independent predictor of @entity3 following multivariate adjustment for gender, age at disease onset and Expanded Disability Status Scale (EDSS) (Adjusted Odds Ratio = 29 (3-298); p = 0.005]. Within the EMS group, @entity0 with (n = 7) and without (n = 22) @entity3 had similar EDSS and disease duration, suggesting similar disease severity. No clear correlation could be found between site of @entity3 and anatomic localization of either clinical relapses or MRI @entity4 -enhancing lesions. CONCLUSIONS: We conclude that @entity3 is an unlikely cause of @entity1 since it is not present in most @entity0 early in the disease and rarely involves more than one extracranial vein. It is likely to be a late secondary phenomenon.

title: XXXX is an unlikely cause of @entity1 .

answer: @entity3


abstract: BACKGROUND: @entity3 ( @entity3 ) has recently been implicated as the primary cause of @entity1 ( @entity1 ). OBJECTIVE: The aim of this study was to determine the presence of @entity3 in @entity1 @entity0 . METHODS: We performed selective extracranial venography on 42 @entity0 with early @entity1 (EMS): @entity2 ( @entity2 ) or @entity5 ( @entity5 ) of less than 5 years duration, and @entity1 ( @entity1 ): @entity5 of more than 10 years duration. Magnetic resonance imaging (MRI) and clinical relapse data were reviewed for all @entity0 with @entity3 . RESULTS: @entity3 was present in 7/29 @entity0 with EMS and 12/13 @entity0 with @entity1 , a highly significant statistical difference (p< 0.001). Only 3/42 @entity0 (all in the @entity1 group) had two vessel stenoses, while the rest had only one vessel involved. @entity3 was seen in 1/11 @entity0 with @entity2 compared with 6/18 @entity5 @entity0 of less than 5 years duration. Disease duration was greater in @entity0 with @entity3 overall (p < 0.005). @entity1 remained an independent predictor of @entity3 following multivariate adjustment for gender, age at disease onset and Expanded Disability Status Scale (EDSS) (Adjusted Odds Ratio = 29 (3-298); p = 0.005]. Within the EMS group, @entity0 with (n = 7) and without (n = 22) @entity3 had similar EDSS and disease duration, suggesting similar disease severity. No clear correlation could be found between site of @entity3 and anatomic localization of either clinical relapses or MRI @entity4 -enhancing lesions. CONCLUSIONS: We conclude that @entity3 is an unlikely cause of @entity1 since it is not present in most @entity0 early in the disease and rarely involves more than one extracranial vein. It is likely to be a late secondary phenomenon.

title: @entity3 is an unlikely cause of XXXX .

answer: @entity1


abstract: BACKGROUND: In a previous study, improvement of antipsychotic-induced blefarospasm and involuntary oral-mandibulo movements were observed with the use of the anticonvulsant drug @entity4 among affectively ill @entity0 who had been exposed to maintenance neuroleptics. The results reported in the present paper represent the sequel to the previous study. METHODS: The purported efficacy of @entity4 in the treatment of @entity3 has been assessed in an open design 1-year follow-up study, in which 30 schizoaffective, @entity2 and @entity1 @entity0 from seven Italian centres were evaluated by means of AIMS. The results showed a statistically significant time-related decrease in AIMS scores. The mean percentage of improvement at AIMS was 47.5+/-18.2%. An improvement of more than 35% after 1 year in 76% of the subjects who completed the trial (n=25) and in 63.3% of the entire sample admitted to the study was revealed. LIMITATION: Open trial. CONCLUSION: The introduction of new antipsychotic drugs has probably already limited the problems related to @entity3 . However, this type of side-effect is also observed during the course of treatment with atypical neuroleptics albeit with a lesser frequency. The fact that @entity4 treatment may have further improved clinical conditions of @entity0 in whom therapeutic protocols had already been modified, appears to suggest exertion of a possible synergic action by the new neuroleptics on @entity3 .

title: @entity4 in antipsychotic-induced XXXX : results of 1-year follow-up.

answer: @entity3


abstract: BACKGROUND: In a previous study, improvement of antipsychotic-induced blefarospasm and involuntary oral-mandibulo movements were observed with the use of the anticonvulsant drug @entity4 among affectively ill @entity0 who had been exposed to maintenance neuroleptics. The results reported in the present paper represent the sequel to the previous study. METHODS: The purported efficacy of @entity4 in the treatment of @entity3 has been assessed in an open design 1-year follow-up study, in which 30 schizoaffective, @entity2 and @entity1 @entity0 from seven Italian centres were evaluated by means of AIMS. The results showed a statistically significant time-related decrease in AIMS scores. The mean percentage of improvement at AIMS was 47.5+/-18.2%. An improvement of more than 35% after 1 year in 76% of the subjects who completed the trial (n=25) and in 63.3% of the entire sample admitted to the study was revealed. LIMITATION: Open trial. CONCLUSION: The introduction of new antipsychotic drugs has probably already limited the problems related to @entity3 . However, this type of side-effect is also observed during the course of treatment with atypical neuroleptics albeit with a lesser frequency. The fact that @entity4 treatment may have further improved clinical conditions of @entity0 in whom therapeutic protocols had already been modified, appears to suggest exertion of a possible synergic action by the new neuroleptics on @entity3 .

title: XXXX in antipsychotic-induced @entity3 : results of 1-year follow-up.

answer: @entity4


abstract: UNASSIGNED: Within afrotherians, sirenians are unusual due to their aquatic lifestyle, large body size and relatively large lissencephalic brain. However, little is known about the neuron type distributions of the cerebral cortex in sirenians within the context of other afrotherians and aquatic mammals. The present study investigated two cortical regions, dorsolateral cortex area 1 (DL1) and cluster cortex area 2 (CL2), in the presumptive primary somatosensory cortex (S1) in @entity2 ( @entity2 latirostris) to characterize cyto- and chemoarchitecture. The mean neuron density for both cortical regions was 35,617 neurons/mm3 and fell within the 95% prediction intervals relative to @entity0 based on a reference group of afrotherians and xenarthrans. Densities of inhibitory interneuron subtypes labeled against @entity1 -binding proteins and neuropeptide Y were relatively low compared to afrotherians and xenarthrans and also formed a small percentage of the overall population of inhibitory interneurons as revealed by GAD67 immunoreactivity. Nonphosphorylated neurofilament protein-immunoreactive (NPNFP-ir) neurons comprised a mean of 60% of neurons in layer V across DL1 and CL2. DL1 contained a higher percentage of NPNFP-ir neurons than CL2, although CL2 had a higher variety of morphological types. The mean percentage of NPNFP-ir neurons in the two regions of the presumptive S1 were low compared to other afrotherians and xenarthrans but were within the 95% prediction intervals relative to @entity0 , and their morphologies were comparable to those found in other afrotherians and xenarthrans. Although this specific pattern of neuron types and densities sets the manatee apart from other afrotherians and xenarthrans, the manatee isocortex does not appear to be explicitly adapted for an aquatic habitat. Many of the features that are shared between manatees and cetaceans are also shared with a diverse array of terrestrial mammals and likely represent highly conserved neural features. A comparative study across manatees and @entity3 is necessary to determine whether these traits are specific to one or more of the manatee species, or can be generalized to all sirenians.

title: Neuron Types in the Presumptive Primary Somatosensory Cortex of the XXXX ( @entity2 latirostris).

answer: @entity2


abstract: UNASSIGNED: Within afrotherians, sirenians are unusual due to their aquatic lifestyle, large body size and relatively large lissencephalic brain. However, little is known about the neuron type distributions of the cerebral cortex in sirenians within the context of other afrotherians and aquatic mammals. The present study investigated two cortical regions, dorsolateral cortex area 1 (DL1) and cluster cortex area 2 (CL2), in the presumptive primary somatosensory cortex (S1) in @entity2 ( @entity2 latirostris) to characterize cyto- and chemoarchitecture. The mean neuron density for both cortical regions was 35,617 neurons/mm3 and fell within the 95% prediction intervals relative to @entity0 based on a reference group of afrotherians and xenarthrans. Densities of inhibitory interneuron subtypes labeled against @entity1 -binding proteins and neuropeptide Y were relatively low compared to afrotherians and xenarthrans and also formed a small percentage of the overall population of inhibitory interneurons as revealed by GAD67 immunoreactivity. Nonphosphorylated neurofilament protein-immunoreactive (NPNFP-ir) neurons comprised a mean of 60% of neurons in layer V across DL1 and CL2. DL1 contained a higher percentage of NPNFP-ir neurons than CL2, although CL2 had a higher variety of morphological types. The mean percentage of NPNFP-ir neurons in the two regions of the presumptive S1 were low compared to other afrotherians and xenarthrans but were within the 95% prediction intervals relative to @entity0 , and their morphologies were comparable to those found in other afrotherians and xenarthrans. Although this specific pattern of neuron types and densities sets the manatee apart from other afrotherians and xenarthrans, the manatee isocortex does not appear to be explicitly adapted for an aquatic habitat. Many of the features that are shared between manatees and cetaceans are also shared with a diverse array of terrestrial mammals and likely represent highly conserved neural features. A comparative study across manatees and @entity3 is necessary to determine whether these traits are specific to one or more of the manatee species, or can be generalized to all sirenians.

title: Neuron Types in the Presumptive Primary Somatosensory Cortex of the @entity2 ( XXXX latirostris).

answer: @entity2


abstract: RATIONALE: @entity5 , @entity4 , @entity6 , @entity9 , and @entity3 are important inflammatory genes associated with immunoglobulin E levels. This study attempts to determine whether there are gene-gene interactions in the five genes among @entity2 @entity0 of Chinese Han nationality. METHODS: Nine single-nucleotide polymorphisms (SNPs) in the five genes were genotyped in 1,000 @entity2 @entity0 and 1,000 healthy controls using TaqMan real-time quantitative polymerase chain reaction. Multifactor-dimensionality reduction method was applied for the analysis. RESULTS: A four-way gene-gene interaction model consisting of @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 was chosen as the optimal one for determining @entity1 susceptibility (testing balanced accuracy   =   0.6089, cross-validation consistency   =   10/10, P   =   6.98E-05). Each of the four SNPs was identified to have an independent association with @entity1 (G allele of @entity7 , odds ratio (OR)   =   1.24, P   =   1.23E-03; T allele of @entity8 , OR   =   1.25, P   =   3.81E-03; A allele of @entity11 , OR   =   1.29, P   =   6.75E-05; G allele of @entity10 , OR   =   1.27, P   =   3.86E-03). Individuals homozygous for the risk alleles at all the four loci ( @entity7 GG, @entity8 TT, @entity11 AA, and @entity10 GG) had a significantly higher risk of @entity1 compared with those without any risk homozygotes (OR   =   13.55, P   =   4.28E-03), and also greater than those with less than four risk homozygotes (OR   =   10.09, P   =   6.51E-03). CONCLUSIONS: Our results suggest that @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 , four SNPs with significant sole effect on @entity1 , interact to confer a higher risk for the disease in Chinese Han @entity0 . Pediatr Pulmonol. 2016;51:364-371.    2015 Wiley Periodicals, Inc.

title: Four-locus gene interaction between @entity5 , @entity4 , @entity9 , and @entity3 for XXXX in Chinese Han @entity0 .

answer: @entity1


abstract: RATIONALE: @entity5 , @entity4 , @entity6 , @entity9 , and @entity3 are important inflammatory genes associated with immunoglobulin E levels. This study attempts to determine whether there are gene-gene interactions in the five genes among @entity2 @entity0 of Chinese Han nationality. METHODS: Nine single-nucleotide polymorphisms (SNPs) in the five genes were genotyped in 1,000 @entity2 @entity0 and 1,000 healthy controls using TaqMan real-time quantitative polymerase chain reaction. Multifactor-dimensionality reduction method was applied for the analysis. RESULTS: A four-way gene-gene interaction model consisting of @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 was chosen as the optimal one for determining @entity1 susceptibility (testing balanced accuracy   =   0.6089, cross-validation consistency   =   10/10, P   =   6.98E-05). Each of the four SNPs was identified to have an independent association with @entity1 (G allele of @entity7 , odds ratio (OR)   =   1.24, P   =   1.23E-03; T allele of @entity8 , OR   =   1.25, P   =   3.81E-03; A allele of @entity11 , OR   =   1.29, P   =   6.75E-05; G allele of @entity10 , OR   =   1.27, P   =   3.86E-03). Individuals homozygous for the risk alleles at all the four loci ( @entity7 GG, @entity8 TT, @entity11 AA, and @entity10 GG) had a significantly higher risk of @entity1 compared with those without any risk homozygotes (OR   =   13.55, P   =   4.28E-03), and also greater than those with less than four risk homozygotes (OR   =   10.09, P   =   6.51E-03). CONCLUSIONS: Our results suggest that @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 , four SNPs with significant sole effect on @entity1 , interact to confer a higher risk for the disease in Chinese Han @entity0 . Pediatr Pulmonol. 2016;51:364-371.    2015 Wiley Periodicals, Inc.

title: Four-locus gene interaction between @entity5 , @entity4 , XXXX , and @entity3 for @entity1 in Chinese Han @entity0 .

answer: @entity9


abstract: RATIONALE: @entity5 , @entity4 , @entity6 , @entity9 , and @entity3 are important inflammatory genes associated with immunoglobulin E levels. This study attempts to determine whether there are gene-gene interactions in the five genes among @entity2 @entity0 of Chinese Han nationality. METHODS: Nine single-nucleotide polymorphisms (SNPs) in the five genes were genotyped in 1,000 @entity2 @entity0 and 1,000 healthy controls using TaqMan real-time quantitative polymerase chain reaction. Multifactor-dimensionality reduction method was applied for the analysis. RESULTS: A four-way gene-gene interaction model consisting of @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 was chosen as the optimal one for determining @entity1 susceptibility (testing balanced accuracy   =   0.6089, cross-validation consistency   =   10/10, P   =   6.98E-05). Each of the four SNPs was identified to have an independent association with @entity1 (G allele of @entity7 , odds ratio (OR)   =   1.24, P   =   1.23E-03; T allele of @entity8 , OR   =   1.25, P   =   3.81E-03; A allele of @entity11 , OR   =   1.29, P   =   6.75E-05; G allele of @entity10 , OR   =   1.27, P   =   3.86E-03). Individuals homozygous for the risk alleles at all the four loci ( @entity7 GG, @entity8 TT, @entity11 AA, and @entity10 GG) had a significantly higher risk of @entity1 compared with those without any risk homozygotes (OR   =   13.55, P   =   4.28E-03), and also greater than those with less than four risk homozygotes (OR   =   10.09, P   =   6.51E-03). CONCLUSIONS: Our results suggest that @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 , four SNPs with significant sole effect on @entity1 , interact to confer a higher risk for the disease in Chinese Han @entity0 . Pediatr Pulmonol. 2016;51:364-371.    2015 Wiley Periodicals, Inc.

title: Four-locus gene interaction between XXXX , @entity4 , @entity9 , and @entity3 for @entity1 in Chinese Han @entity0 .

answer: @entity5


abstract: RATIONALE: @entity5 , @entity4 , @entity6 , @entity9 , and @entity3 are important inflammatory genes associated with immunoglobulin E levels. This study attempts to determine whether there are gene-gene interactions in the five genes among @entity2 @entity0 of Chinese Han nationality. METHODS: Nine single-nucleotide polymorphisms (SNPs) in the five genes were genotyped in 1,000 @entity2 @entity0 and 1,000 healthy controls using TaqMan real-time quantitative polymerase chain reaction. Multifactor-dimensionality reduction method was applied for the analysis. RESULTS: A four-way gene-gene interaction model consisting of @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 was chosen as the optimal one for determining @entity1 susceptibility (testing balanced accuracy   =   0.6089, cross-validation consistency   =   10/10, P   =   6.98E-05). Each of the four SNPs was identified to have an independent association with @entity1 (G allele of @entity7 , odds ratio (OR)   =   1.24, P   =   1.23E-03; T allele of @entity8 , OR   =   1.25, P   =   3.81E-03; A allele of @entity11 , OR   =   1.29, P   =   6.75E-05; G allele of @entity10 , OR   =   1.27, P   =   3.86E-03). Individuals homozygous for the risk alleles at all the four loci ( @entity7 GG, @entity8 TT, @entity11 AA, and @entity10 GG) had a significantly higher risk of @entity1 compared with those without any risk homozygotes (OR   =   13.55, P   =   4.28E-03), and also greater than those with less than four risk homozygotes (OR   =   10.09, P   =   6.51E-03). CONCLUSIONS: Our results suggest that @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 , four SNPs with significant sole effect on @entity1 , interact to confer a higher risk for the disease in Chinese Han @entity0 . Pediatr Pulmonol. 2016;51:364-371.    2015 Wiley Periodicals, Inc.

title: Four-locus gene interaction between @entity5 , XXXX , @entity9 , and @entity3 for @entity1 in Chinese Han @entity0 .

answer: @entity4


abstract: RATIONALE: @entity5 , @entity4 , @entity6 , @entity9 , and @entity3 are important inflammatory genes associated with immunoglobulin E levels. This study attempts to determine whether there are gene-gene interactions in the five genes among @entity2 @entity0 of Chinese Han nationality. METHODS: Nine single-nucleotide polymorphisms (SNPs) in the five genes were genotyped in 1,000 @entity2 @entity0 and 1,000 healthy controls using TaqMan real-time quantitative polymerase chain reaction. Multifactor-dimensionality reduction method was applied for the analysis. RESULTS: A four-way gene-gene interaction model consisting of @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 was chosen as the optimal one for determining @entity1 susceptibility (testing balanced accuracy   =   0.6089, cross-validation consistency   =   10/10, P   =   6.98E-05). Each of the four SNPs was identified to have an independent association with @entity1 (G allele of @entity7 , odds ratio (OR)   =   1.24, P   =   1.23E-03; T allele of @entity8 , OR   =   1.25, P   =   3.81E-03; A allele of @entity11 , OR   =   1.29, P   =   6.75E-05; G allele of @entity10 , OR   =   1.27, P   =   3.86E-03). Individuals homozygous for the risk alleles at all the four loci ( @entity7 GG, @entity8 TT, @entity11 AA, and @entity10 GG) had a significantly higher risk of @entity1 compared with those without any risk homozygotes (OR   =   13.55, P   =   4.28E-03), and also greater than those with less than four risk homozygotes (OR   =   10.09, P   =   6.51E-03). CONCLUSIONS: Our results suggest that @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 , four SNPs with significant sole effect on @entity1 , interact to confer a higher risk for the disease in Chinese Han @entity0 . Pediatr Pulmonol. 2016;51:364-371.    2015 Wiley Periodicals, Inc.

title: Four-locus gene interaction between @entity5 , @entity4 , @entity9 , and XXXX for @entity1 in Chinese Han @entity0 .

answer: @entity3


abstract: RATIONALE: @entity5 , @entity4 , @entity6 , @entity9 , and @entity3 are important inflammatory genes associated with immunoglobulin E levels. This study attempts to determine whether there are gene-gene interactions in the five genes among @entity2 @entity0 of Chinese Han nationality. METHODS: Nine single-nucleotide polymorphisms (SNPs) in the five genes were genotyped in 1,000 @entity2 @entity0 and 1,000 healthy controls using TaqMan real-time quantitative polymerase chain reaction. Multifactor-dimensionality reduction method was applied for the analysis. RESULTS: A four-way gene-gene interaction model consisting of @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 was chosen as the optimal one for determining @entity1 susceptibility (testing balanced accuracy   =   0.6089, cross-validation consistency   =   10/10, P   =   6.98E-05). Each of the four SNPs was identified to have an independent association with @entity1 (G allele of @entity7 , odds ratio (OR)   =   1.24, P   =   1.23E-03; T allele of @entity8 , OR   =   1.25, P   =   3.81E-03; A allele of @entity11 , OR   =   1.29, P   =   6.75E-05; G allele of @entity10 , OR   =   1.27, P   =   3.86E-03). Individuals homozygous for the risk alleles at all the four loci ( @entity7 GG, @entity8 TT, @entity11 AA, and @entity10 GG) had a significantly higher risk of @entity1 compared with those without any risk homozygotes (OR   =   13.55, P   =   4.28E-03), and also greater than those with less than four risk homozygotes (OR   =   10.09, P   =   6.51E-03). CONCLUSIONS: Our results suggest that @entity5 @entity7 , @entity4 @entity8 , @entity3 @entity11 , and @entity9 @entity10 , four SNPs with significant sole effect on @entity1 , interact to confer a higher risk for the disease in Chinese Han @entity0 . Pediatr Pulmonol. 2016;51:364-371.    2015 Wiley Periodicals, Inc.

title: Four-locus gene interaction between @entity5 , @entity4 , @entity9 , and @entity3 for @entity1 in Chinese Han XXXX .

answer: @entity0


abstract: An association between @entity1 and reproductive disturbances with an apparent increase in a @entity10 ( @entity10 ) has been reported. Whether this association can be attributed to @entity1 itself or is related to antiepileptic drug therapy, in particular @entity4 ( @entity7 ), remains controversial. We studied effects of a long-term @entity7 treatment on cycling monkeys, postulating that, if @entity7 monotherapy were to promote abnormal endocrine and metabolic parameters that are characteristic of @entity10 , changes in cyclicity would be readily demonstrated. After a 2-month control, a 12- to 15-month @entity7 monotherapy was initiated in 7 regularly cycling @entity8 . Overall mean levels of @entity7 were 88.7 +/- 4.0 (SE) microg/ml. Mean body weight increased progressively during @entity7 treatment from 8.5 +/- 0.5 kg before treatment to 9.6 +/- 0.7 kg in the last week of treatment (P < 0.05). Monkeys continued to have regular ovulatory menstrual cycles throughout @entity7 monotherapy. Length of the cycles was 28 +/- 0.58 d in control and 28.4 +/- 1.18 d in the last 3 months of @entity7 treatment. Follicular and luteal lengths and peak preovulatory @entity0 and integrated luteal @entity6 levels did not differ between control and treatment. Ovaries from @entity7 -treated monkeys showed histological evidence of ovulation, and none had characteristic features of @entity10 . Endocrine @entity10 markers, such as increased early follicular LH/FSH ratio and @entity2 levels were not different in control and @entity7 treatment cycles. LH and @entity11 responses to @entity5 agonist challenges and the insulin response to @entity3 tolerance tests were similar in control and @entity7 groups. Lipid profiles were not affected by @entity7 treatment. The data indicate that a 12- to 15-month therapeutic exposure to @entity7 does not induce cyclic hormonal or morphological @entity9 or characteristics of the @entity10 when administered to nonepileptic normally cycling nonhuman primates.

title: Endocrine and metabolic responses to long-term monotherapy with the antiepileptic drug XXXX in the normally cycling @entity8 .

answer: @entity4


abstract: An association between @entity1 and reproductive disturbances with an apparent increase in a @entity10 ( @entity10 ) has been reported. Whether this association can be attributed to @entity1 itself or is related to antiepileptic drug therapy, in particular @entity4 ( @entity7 ), remains controversial. We studied effects of a long-term @entity7 treatment on cycling monkeys, postulating that, if @entity7 monotherapy were to promote abnormal endocrine and metabolic parameters that are characteristic of @entity10 , changes in cyclicity would be readily demonstrated. After a 2-month control, a 12- to 15-month @entity7 monotherapy was initiated in 7 regularly cycling @entity8 . Overall mean levels of @entity7 were 88.7 +/- 4.0 (SE) microg/ml. Mean body weight increased progressively during @entity7 treatment from 8.5 +/- 0.5 kg before treatment to 9.6 +/- 0.7 kg in the last week of treatment (P < 0.05). Monkeys continued to have regular ovulatory menstrual cycles throughout @entity7 monotherapy. Length of the cycles was 28 +/- 0.58 d in control and 28.4 +/- 1.18 d in the last 3 months of @entity7 treatment. Follicular and luteal lengths and peak preovulatory @entity0 and integrated luteal @entity6 levels did not differ between control and treatment. Ovaries from @entity7 -treated monkeys showed histological evidence of ovulation, and none had characteristic features of @entity10 . Endocrine @entity10 markers, such as increased early follicular LH/FSH ratio and @entity2 levels were not different in control and @entity7 treatment cycles. LH and @entity11 responses to @entity5 agonist challenges and the insulin response to @entity3 tolerance tests were similar in control and @entity7 groups. Lipid profiles were not affected by @entity7 treatment. The data indicate that a 12- to 15-month therapeutic exposure to @entity7 does not induce cyclic hormonal or morphological @entity9 or characteristics of the @entity10 when administered to nonepileptic normally cycling nonhuman primates.

title: Endocrine and metabolic responses to long-term monotherapy with the antiepileptic drug @entity4 in the normally cycling XXXX .

answer: @entity8


abstract: OBJECTIVE: The purpose of this study was to investigate gelatinase ( @entity4 and @entity5 ) expression in @entity3 ( @entity3 ) and to explore the mechanisms that may inhibit gelatinase activity. STUDY DESIGN: Thirty biopsy specimens of OSCCs were examined by means of immunohistochemistry. Supernatants from primary cultures of @entity0 oral mucosal keratinocyte and @entity1 -derived cells (KB and @entity7 ) were analyzed by means of gelatin zymography. Furthermore, @entity6 ( @entity6 ) inhibitors (H7 and @entity2 ) were added to test how they modulate gelatinase production in @entity0 @entity1 cells. RESULTS: @entity4 and @entity5 expression was significantly higher in oral SCCs and was located in discrete clusters of @entity1 cells. Oral mucosal keratinocyte cultures, KB, and @entity7 were found to secrete and produce @entity4 and @entity5 . However, the amounts of @entity4 and @entity5 were highly elevated in the 2 @entity1 cell lines in comparison with oral mucosal keratinocyte cultures (P <.05). In addition, @entity6 inhibitors were found to decrease @entity4 and @entity5 activities in @entity1 cells (P <.05). CONCLUSION: Taken together, @entity0 oral SCCs produce @entity4 and @entity5 in vivo and in vitro, and gelatinase activity is down-regulated by @entity6 inhibitors in vitro. @entity6 inhibitors suppressing MMP production and/or activity may represent valuable therapeutic agents through their influence on the pathogenesis of @entity3 . These agents may prove clinically useful in combination with standard therapeutic modalities for the treatment of @entity0 with @entity1 .

title: Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in @entity0 XXXX and the effect of @entity6 inhibitors: preliminary observations.

answer: @entity3


abstract: OBJECTIVE: The purpose of this study was to investigate gelatinase ( @entity4 and @entity5 ) expression in @entity3 ( @entity3 ) and to explore the mechanisms that may inhibit gelatinase activity. STUDY DESIGN: Thirty biopsy specimens of OSCCs were examined by means of immunohistochemistry. Supernatants from primary cultures of @entity0 oral mucosal keratinocyte and @entity1 -derived cells (KB and @entity7 ) were analyzed by means of gelatin zymography. Furthermore, @entity6 ( @entity6 ) inhibitors (H7 and @entity2 ) were added to test how they modulate gelatinase production in @entity0 @entity1 cells. RESULTS: @entity4 and @entity5 expression was significantly higher in oral SCCs and was located in discrete clusters of @entity1 cells. Oral mucosal keratinocyte cultures, KB, and @entity7 were found to secrete and produce @entity4 and @entity5 . However, the amounts of @entity4 and @entity5 were highly elevated in the 2 @entity1 cell lines in comparison with oral mucosal keratinocyte cultures (P <.05). In addition, @entity6 inhibitors were found to decrease @entity4 and @entity5 activities in @entity1 cells (P <.05). CONCLUSION: Taken together, @entity0 oral SCCs produce @entity4 and @entity5 in vivo and in vitro, and gelatinase activity is down-regulated by @entity6 inhibitors in vitro. @entity6 inhibitors suppressing MMP production and/or activity may represent valuable therapeutic agents through their influence on the pathogenesis of @entity3 . These agents may prove clinically useful in combination with standard therapeutic modalities for the treatment of @entity0 with @entity1 .

title: Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in @entity0 @entity3 and the effect of XXXX inhibitors: preliminary observations.

answer: @entity6


abstract: OBJECTIVE: The purpose of this study was to investigate gelatinase ( @entity4 and @entity5 ) expression in @entity3 ( @entity3 ) and to explore the mechanisms that may inhibit gelatinase activity. STUDY DESIGN: Thirty biopsy specimens of OSCCs were examined by means of immunohistochemistry. Supernatants from primary cultures of @entity0 oral mucosal keratinocyte and @entity1 -derived cells (KB and @entity7 ) were analyzed by means of gelatin zymography. Furthermore, @entity6 ( @entity6 ) inhibitors (H7 and @entity2 ) were added to test how they modulate gelatinase production in @entity0 @entity1 cells. RESULTS: @entity4 and @entity5 expression was significantly higher in oral SCCs and was located in discrete clusters of @entity1 cells. Oral mucosal keratinocyte cultures, KB, and @entity7 were found to secrete and produce @entity4 and @entity5 . However, the amounts of @entity4 and @entity5 were highly elevated in the 2 @entity1 cell lines in comparison with oral mucosal keratinocyte cultures (P <.05). In addition, @entity6 inhibitors were found to decrease @entity4 and @entity5 activities in @entity1 cells (P <.05). CONCLUSION: Taken together, @entity0 oral SCCs produce @entity4 and @entity5 in vivo and in vitro, and gelatinase activity is down-regulated by @entity6 inhibitors in vitro. @entity6 inhibitors suppressing MMP production and/or activity may represent valuable therapeutic agents through their influence on the pathogenesis of @entity3 . These agents may prove clinically useful in combination with standard therapeutic modalities for the treatment of @entity0 with @entity1 .

title: Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in XXXX @entity3 and the effect of @entity6 inhibitors: preliminary observations.

answer: @entity0


abstract: BACKGROUND/AIM: Transurethral catheterization is generally associated with a higher incidence of @entity2 than suprapubic catheterization; however, suprapubic catheterization is associated with other disadvantages such as higher costs and a more difficult technique, and at the moment there is no consensus about the use of both catheter systems. Therefore, a prospective randomized study was performed to investigate the effects of suprapubic catheterization and transurethral catheterization in @entity0 undergoing surgery on the incidence of @entity2 and @entity0 satisfaction. METHODS: @entity0 who underwent an elective laparotomy were randomized and received a suprapubic or transurethral catheter. The primary end point was @entity2 . Other parameters of @entity2 , as well as duration of catheterization, hospital stay, and number of recatheterizations and of relaparotomies were monitored. Treatment 'per protocol' was also analyzed after exclusion of @entity0 receiving another catheter than randomized for. @entity0 were asked for their satisfaction with the catheters and complaints during and after catheterization. RESULTS: 165 @entity0 were eligible, of whom 19 @entity0 had to be excluded. 75 @entity0 were allocated to receive the suprapubic catheter and 71 the transurethral catheter. There was no difference in the incidence of a @entity2 between the suprapubic group (n = 9/75; 12%) and the transurethral group (n = 8/71; 11%). Most @entity0 (6/9) who developed a @entity2 in the suprapubic group, however, underwent recatheterization because of @entity1 / @entity3 and relaparotomy. The incidence of @entity2 in @entity0 who received a suprapubic catheter and not a transurethral catheter was 3/59 (5%). The @entity0 did not differ with respect to satisfaction and complaints. Being a @entity0 , recatheterization and duration of catheterization are risk factors. CONCLUSIONS: The incidence of a @entity2 between a suprapubic catheter and a transurethral catheter in @entity0 undergoing major surgery was not different. A potential advantage of the suprapubic catheter ( @entity2 ) is probably partly negated, because transurethral catheters were used if recatheterization was indicated during the postoperative stay or due to complications.

title: The effect of suprapubic catheterization versus transurethral catheterization after abdominal surgery on XXXX : a randomized controlled trial.

answer: @entity2


abstract: BACKGROUND: Arthroscopic debridement has been widely adapted as initial treatment for @entity3 . Although isolated cases of arthroscopic debridement combined with irrigation-suction systems have been reported, a comparison of two techniques has not been performed, to our knowledge. The purpose of this study was to compare the two methods of treatment. METHODS: From January 1996 to December 2008, 39 @entity0 with 39 @entity3 treated in our institution were retrospectively analyzed. Nineteen knees were initially treated with arthroscopic debridement alone (group I), and 20 knees were initially treated with arthroscopic debridement combined with continuous closed irrigation-suction system (group II). The clinical presentation, laboratory and microbiologic findings, hospital course, and clinical outcomes were compared between the two groups. RESULTS: The mean delay between the onset of the symptoms and treatment had a significant effect on the clinical outcomes. When the comparison included all the @entity0 in the series, no significant difference between the two groups was found with regard to the number of operation procedures required or the length of the hospital stay. However, when the comparison was separated from the initial stage of @entity2 , it was found that in @entity1 , @entity0 had fewer reoperations and in @entity1 , a shorter hospital stay in group II than in group I (p < 0.05). There was no significant difference in the functional results between the two groups. CONCLUSIONS: The early diagnosis and aggressive initiation of treatment carried the success of therapy in @entity3 . Arthroscopic debridement combined with continuous closed irrigation-suction system is an effective treatment for @entity0 with @entity3 ; these @entity0 had fewer operations and a shorter hospital stay than did @entity0 who had received arthroscopic debridement alone.

title: Treatment of XXXX : comparison of arthroscopic debridement alone or combined with continuous closed irrigation-suction system.

answer: @entity3


abstract: UNASSIGNED: The addition of antiangiogenic therapy to the standard-of-care treatment regimen for recurring @entity4 has provided some clinical benefits while also delineating numerous caveats, prompting evaluation of the elicited alterations to the @entity0 microenvironment. Of critical importance, given the steadily increasing incorporation of immunotherapeutic approaches clinically, is an enhanced understanding of the interplay between angiogenic and immune response pathways within @entity0 . In the present study, the GL261 @entity1 @entity2 model was used to determine the effects of antiangiogenic treatment in an immune-competent host. Following weekly systemic administration of aflibercept, an inhibitor of vascular endothelial growth factor, @entity0 volume was assessed by magnetic resonance imaging and changes to the @entity0 microenvironment were determined. Treatment with aflibercept resulted in reduced @entity0 burden and increased survival compared with controls. Additionally, decreased vascular permeability and preservation of the integrity of tight junction proteins were observed. Treated @entity0 also displayed hallmarks of anti-angiogenic evasion, including marked upregulation of vascular endothelial growth factor expression and increased @entity0 invasiveness. Aflibercept was then administered in combination with a picornavirus-based antitumor vaccine and @entity0 progression was evaluated. This combination therapy significantly delayed @entity0 progression and extended survival beyond that observed for either therapy alone. As such, this work demonstrates the efficacy of combined antiangiogenic and immunotherapy approaches for treating established @entity1 and provides a foundation for further evaluation of the effects of antiangiogenic therapy in the context of endogenous or vaccine-induced @entity3 responses.

title: Improved Treatment Efficacy of Antiangiogenic Therapy when Combined with Picornavirus Vaccination in the GL261 XXXX Model.

answer: @entity1


abstract: BACKGROUND: @entity7 is a rare and disabling disease that can result in chronic fibrous thickening of the pericardium. The purpose of this study was to evaluate the long-term outcomes following treatment of @entity7 by pericardiectomy. METHODS: Between September 1992 and May 2014, 47 @entity0 who underwent pericardiectomy for @entity7 were retrospectively examined. Demographic, pre-, intra- and postoperative data and long-term outcomes were analyzed. RESULTS: Thirty of the @entity0 were male, the mean age was 45.8        16.7. Aetiology of @entity7 was @entity4 in 22 (46.8  %) @entity0 , idiopathic in 15 (31.9  %), @entity1 in 3 (6.4  %), prior cardiac surgery in 2 (4.3  %), @entity6 in 2 (4.3  %), radiotherapy in 1 (2.1  %), uraemia in 1 (2.1  %) and post-traumatic in 1 (2.1  %). The surgical approach was achieved via a median sternotomy in all @entity0 except only 1 @entity0 . The mean operative time was 156.4        45.7  min. Improvement in functional status in 80  % of @entity0 ' at least one New York Heart Association (NYHA) functional class was observed. In-hospital mortality rate was 2.1  % (1 of 47 @entity0 ). The cause of @entity3 was @entity2 leading to progressive @entity5 . The late mortality rate was 23.4  % (11 of 47 @entity0 ). The mean follow-up time was 61.2        66  months. The actuarial survival rates were 91  %, 85  % and 81  % at 1, 5 and 10  years, respectively. Recurrence requiring a repeat pericardiectomy was developed in no @entity0 during follow-up. CONCLUSION: Pericardiectomy is associated with high morbidity and mortality rates. Cases with @entity1 , diminished cardiac output, cases in need of reoperation are expected to have high mortality rates and less chance of functional recovery.

title: Long-term outcomes of pericardiectomy for XXXX .

answer: @entity7


abstract: UNASSIGNED: Although most studies support the beneficial effects of @entity6 on neurocognition, its effects have never been assessed in @entity2 @entity0 . In addition, results from studies in smokers are contradictory. Moreover, there are no data available about the neurocognitive effects of @entity6 and @entity5 together. We explored the concomitant effects of regular @entity6 and @entity5 intake on neurocognition in 52 @entity3 @entity0 and 61 healthy controls. Verbal fluency, processing speed, and working, @entity4 were assessed. For each measurement, two tasks with two levels of complexity were administered. Our results showed that @entity6 intake had beneficial effects on male @entity3 @entity0 only in complex tasks requiring deeper cognitive processing (semantic fluency, @entity1 ). Female @entity0 and controls were unaffected. In contrast, smoking had a negative effect on male, but not on female, @entity3 @entity0 in semantic fluency. The effects of smoking in controls were inconsistent. In conclusion, our data showed, for the first time, beneficial effects of @entity6 intake on neurocognition in male @entity3 @entity0 . These data suggest that further research of therapeutics based on @entity6 is needed, as this could be beneficial for @entity3 @entity0 . In contrast, smoking appears to be detrimental.

title: Effects of @entity6 intake and smoking on neurocognition in XXXX .

answer: @entity3


abstract: UNASSIGNED: Although most studies support the beneficial effects of @entity6 on neurocognition, its effects have never been assessed in @entity2 @entity0 . In addition, results from studies in smokers are contradictory. Moreover, there are no data available about the neurocognitive effects of @entity6 and @entity5 together. We explored the concomitant effects of regular @entity6 and @entity5 intake on neurocognition in 52 @entity3 @entity0 and 61 healthy controls. Verbal fluency, processing speed, and working, @entity4 were assessed. For each measurement, two tasks with two levels of complexity were administered. Our results showed that @entity6 intake had beneficial effects on male @entity3 @entity0 only in complex tasks requiring deeper cognitive processing (semantic fluency, @entity1 ). Female @entity0 and controls were unaffected. In contrast, smoking had a negative effect on male, but not on female, @entity3 @entity0 in semantic fluency. The effects of smoking in controls were inconsistent. In conclusion, our data showed, for the first time, beneficial effects of @entity6 intake on neurocognition in male @entity3 @entity0 . These data suggest that further research of therapeutics based on @entity6 is needed, as this could be beneficial for @entity3 @entity0 . In contrast, smoking appears to be detrimental.

title: Effects of XXXX intake and smoking on neurocognition in @entity3 .

answer: @entity6


abstract: The @entity0 bone marrow culture technique was used to prepare donor marrow for @entity1 minor histocompatibility complex differences. Previous studies have shown that theta-positive cells are rapidly lost from such cultures and that transplantation of cultured marrow across major histocompatibility complex differences results in a delay in the development of lethal @entity2 ( @entity2 ). In this study, a total of 1 to 2 X 10(7) nonadherent cells (740 to 1560 CFUs [colony-forming units]) from three-day-old cultures were used as a source of donor marrow. Three strain combinations were evaluated; LP/J into C57BL/6; BIO.BR into CBA/J; and C57BL/6 into LP/J. Donor @entity0 were immunized with recipient spleen cells prior to culture in order to increase the graft-v-host response. For LP/J marrow into C57BL/6 @entity0 , 5 X 10(7) donor spleen cells transplanted along with the marrow were needed to induce lethal @entity2 . However, lethal @entity2 was seen without the addition of spleen cells for BIO.BR into CBA/J and C57BL/6 into LP/J strain combinations. Most animals receiving fresh marrow were dead of @entity2 five weeks after transplantation. With the use of cultured marrow the three-month survival was 80%, 51%, and 93%, respectively, for LP/J into C57BL/6, BIO.BR into CBA/J, and C57BL/6 into LP/J strain combinations. Long-term donor engraftment in all recipient animals receiving cultured marrow was confirmed by analyzing hemoglobin polymorphisms between the strain combinations. These results demonstrate that in contrast to transplantation across major histocompatibility complex differences, the use of cultured cells for @entity1 minor histocompatibility complex differences allows for engraftment while reducing the risk of lethal @entity2 .

title: Reduction of lethal graft-versus-host disease: transplantation of cultured XXXX bone marrow across minor histocompatibility differences.

answer: @entity0


abstract: Numerous biological tests point to the diagnosis of food sensitization: detection of specific @entity6 by Rast techniques, multi-detection assays, immunoblotting, screening of basophil activation (BAT or FAST), assays for leukotriene LTC4 release (CAST), measurement of plasma @entity1 , serum tryptase, serum ECP, urinary EDN, completed by @entity3 - @entity5 test evaluating intestinal permeability, assay of fecal @entity6 , Rast for specific IgG4. Primary screening for anti-food @entity6 by multi-detection assays seeks justification from insufficient clinical data and false positive tests are common in @entity0 sensitized to pollens or latex, on account of in vitro cross reactivities (CR). Multiple CR explain positive Rast to vegetal food allergens in such @entity0 . Biological tests should not be performed as the first line of diagnosis. In vivo sensitisation is assessed by positive prick-tests, demonstrating the bivalence of allergens, as well as the affinity of specific @entity6 , two conditions necessary to bridge membrane bound specific @entity6 , leading to the release of mediators. Prick-tests are closer to clinical symptoms than biological tests. However, the diagnosis of @entity4 is based on standardised oral challenges. Exceptions are high levels of specific @entity6 to egg (> 6 kUl/l), peanut (> 15 kUl/l), fish (> 20 kUl/l) and milk (> 32 kUl/l), reaching a 95% predictive positive value. Rast inhibition tests are useful to identify masked allergens in foods. Research developments will have impact on the development of new diagnostic tools: allergen mixes reinforcing a food extract by associated recombinant major allergens, multiple combination of recombinant allergens (chips) or tests with synthetic epitopes aimed a the prediction of recovery. Laboratory tests take place in the decision free for the diagnosis for the @entity4 and the follow-up of the levels specific @entity6 is a tool to assess outcome and contributes to predict recovery or persistent @entity2 . Up to now the significance of positive laboratory tests showing the implication of @entity6 is at the crossroads of the allergist's and biologist's expertise.

title: Laboratory tests for diagnosis of XXXX : advantages, disadvantages and future perspectives.

answer: @entity4


abstract: @entity7 have been shown to inhibit @entity0 growth in several model systems. In this paper evidence that immune effectors are important for this effect is discussed. Injection of @entity4 (RA) into @entity1 before challenge with allogeneic or syngeneic @entity0 cells results in a strong increase in cell-mediated @entity2 specific for the respective @entity0 . This stimulation appears to be due to effects taking place before or during the induction phase rather than the effector phase of cell-mediated cytolysis. The effector cells responsible for @entity2 express the @entity6 , are H-2 specific and are therefore T killer cells. The induction of T cell-mediated @entity2 requires the participation of the lymphokine interleukin 2 ( @entity5 ). The possibility was tested that RA directly or indirectly influences the production of @entity5 and thereby stimulates the induction of T killer cells. Results indeed show that RA-injected @entity1 display an increased capacity to produce @entity5 upon stimulation of their splenocytes in a mixed lymphocyte reaction. It appears therefore that RA has an effect on T cells that are destined to produce @entity5 upon antigenic challenge. Since @entity5 plays a role not only in the induction of specific cytotoxic T cells but also in the induction of natural killer (NK) cells, RA was also tested in a model system in which NK cells appear to play an important protective role. Results showed that split-dose irradiated @entity1 that lose their NK activity and subsequently develop @entity3 can be protected from leukaemogenesis either by reconstitution with NK cells or by injection with RA. The question of whether this effect is due to stimulation of immune effectors or is a direct effect on the preleukaemic cells is discussed.

title: Immunostimulation by XXXX .

answer: @entity4


abstract: INTRODUCTION: @entity7 is a multisystemic disease of unknown etiology with diverse clinical symptoms depending on the organ affected. Plasma of affected @entity0 contains a specific anticoagulant called @entity9 . It is an antibody which belongs to the class of antiphospholipid antibodies which bind to phospolipid-binding proteins, molecules of natural coagulation inhibitors, thus increasing the risk of @entity4 . @entity7 commonly affects the skin, joints, serosa, hematopoietic tissue, kidneys and the nervous system. Pulmonary symptoms may manifest as @entity10 , @entity1 , chronic @entity3 , but @entity6 is the most common pulmonary manifestation. CASE REPORT: This is a case report of a young female @entity0 who has been suffering from @entity7 for twenty years. She was treated for superficial @entity8 for several times. She was admitted to our hospital a year before, when she developed @entity6 following @entity5 of the right leg, although at that time she was treated by oral anticoagulants. She was discharged from hospital with vena cava filter placement and further anticoagulant treatment. In a one year period she was hospitalized again due to @entity6 . DISCUSSION: @entity4 in @entity7 are more frequent in patients with antiphospholipid antibodies. Prevention of @entity4 complications by anticoagulant agents in @entity0 who already developed @entity4 manifestations is considered necessary. CONCLUSION: Anticoagulant treatment should be, for preventive reasons, introduced in all @entity0 with a @entity2 and with anticoagulant factor, even if they haven't developed a @entity4 attack and they should undergo prothrombin time measurements and INR: 3-4.

title: [Pulmonary thromboembolism and XXXX in the antiphospholipid syndrome--case report].

answer: @entity5


abstract: During a 14 year period, 22 @entity0 with stricture, acute @entity2 , and @entity1 were treated. Nine @entity0 had postintubation @entity6 and underwent tracheal resection with good to excellent results. Six @entity0 had strictures after tracheostomy. In one @entity0 , @entity4 occurred after repair and repeated dilatation was necessary. He subsequently had to undergo repeat tracheostomy, but the tube was later removed and his symptoms disappeared. Our current preference for suture is either 3-0 @entity8 or @entity7 . Acute separation of the @entity3 can occur with @entity2 to the neck, either by garrotting or direct blunt force. The diagnosis is suspected when endotracheal intubation is impossible and a step off below the larynx and crepitation exists. Emergency tracheostomy is necessary, however, and primary repair can be delayed for up to 24 hours if other conditions require attention. Tracheal resection for @entity5 is possible, but only a small group of @entity0 may be surgical candidates.

title: Management of acute and chronic disorders of the XXXX and subglottis.

answer: @entity3


abstract: beta (0)- @entity2 /Hb E in Southeast Asia varies greatly in severity, with hemoglobin levels ranging from 2.5 to 13.5 g/dl, averaging 7.7 g/dl. Results of systematic investigations to find out what determines different levels of severity are reviewed. Concomitant inheritance of @entity3 significantly decreases the severity. Different degrees of severity in the majority of cases, however, is not due to @entity3 . Concordance of hemoglobin levels among @entity0 who are sibs prevails, suggesting polygenic factor determinants. Potential factors ruled out as determinants for different levels of severity are discriminating fetal hemoglobin production, erythrocyte @entity1 dismutase activity, reticulo-endothelial function, and failure of erythropoiesis compensation. Red cell survival and globin synthesis studies indicate that different degrees of excess of alpha-chains leading to different red cell pathology and survival are responsible for variable severity. Degrees of excess of alpha-chains in this circumstance are probably mainly determined by erythrocyte proteolytic activity. The relationship between the hemoglobin levels and erythrocyte cytosol proteolytic activity in 15 beta(0) - @entity2 /Hb E disease @entity0 in whom a deletional type of @entity3 had been ruled out by DNA mapping is striking, with a correlation coefficient of 0.78. This finding suggests that modulation of erythrocyte proteolysis is another approach for treatment of @entity2 .

title: @entity2 in southeast Asia: determination of different degrees of severity of anemia in XXXX .

answer: @entity2


abstract: beta (0)- @entity2 /Hb E in Southeast Asia varies greatly in severity, with hemoglobin levels ranging from 2.5 to 13.5 g/dl, averaging 7.7 g/dl. Results of systematic investigations to find out what determines different levels of severity are reviewed. Concomitant inheritance of @entity3 significantly decreases the severity. Different degrees of severity in the majority of cases, however, is not due to @entity3 . Concordance of hemoglobin levels among @entity0 who are sibs prevails, suggesting polygenic factor determinants. Potential factors ruled out as determinants for different levels of severity are discriminating fetal hemoglobin production, erythrocyte @entity1 dismutase activity, reticulo-endothelial function, and failure of erythropoiesis compensation. Red cell survival and globin synthesis studies indicate that different degrees of excess of alpha-chains leading to different red cell pathology and survival are responsible for variable severity. Degrees of excess of alpha-chains in this circumstance are probably mainly determined by erythrocyte proteolytic activity. The relationship between the hemoglobin levels and erythrocyte cytosol proteolytic activity in 15 beta(0) - @entity2 /Hb E disease @entity0 in whom a deletional type of @entity3 had been ruled out by DNA mapping is striking, with a correlation coefficient of 0.78. This finding suggests that modulation of erythrocyte proteolysis is another approach for treatment of @entity2 .

title: XXXX in southeast Asia: determination of different degrees of severity of anemia in @entity2 .

answer: @entity2


abstract: The efficacy of @entity4 in treating acute @entity2 and @entity6 after open heart surgery was compared with that of a digoxin/ @entity7 combination. Forty adult @entity0 with postoperative @entity1 were randomised into either group 1 ( @entity4 1 mg/kg bolus intravenously plus 0.2 mg/kg intravenously over 12 hours) or group 2 (digoxin 0.75 mg intravenously, then two hours later @entity7 2 mg/kg intravenous bolus and 0.4 mg/kg/h intravenously for 10 hours). In each group, 17 out of 20 @entity0 reverted to sinus or junctional rhythm within 12 hours. The time to reversion in group 1 was significantly shorter than in group 2. Systolic blood pressure fell by greater than or equal to 20 mm Hg or to less than or equal to 90 mm Hg during drug administration in 17 out of 20 @entity0 in group 1 ( @entity4 withdrawn in two) and in none out of 20 in group 2. Two @entity0 in group 1 developed transient @entity3 ( @entity4 withdrawn in one). None of 17 @entity0 in group 1 and two of 17 in group 2 relapsed temporarily into @entity2 during the 12 hours of intravenous treatment. On continued oral treatment, one late relapse occurred in group 1 and five in group 2, and five @entity0 in group 2 had @entity7 withdrawn because of anticholinergic side effects (acute urinary retention in four). @entity4 was as effective as the digoxin/ @entity7 combination and acted significantly faster. Sensitivity to beta blockade in these @entity0 may be related to high plasma @entity5 concentrations known to occur after cardiopulmonary bypass.

title: Intravenous @entity4 for the treatment of @entity2 and XXXX after cardiopulmonary bypass. Comparison with @entity7 and digoxin in a randomised trial.

answer: @entity6


abstract: The efficacy of @entity4 in treating acute @entity2 and @entity6 after open heart surgery was compared with that of a digoxin/ @entity7 combination. Forty adult @entity0 with postoperative @entity1 were randomised into either group 1 ( @entity4 1 mg/kg bolus intravenously plus 0.2 mg/kg intravenously over 12 hours) or group 2 (digoxin 0.75 mg intravenously, then two hours later @entity7 2 mg/kg intravenous bolus and 0.4 mg/kg/h intravenously for 10 hours). In each group, 17 out of 20 @entity0 reverted to sinus or junctional rhythm within 12 hours. The time to reversion in group 1 was significantly shorter than in group 2. Systolic blood pressure fell by greater than or equal to 20 mm Hg or to less than or equal to 90 mm Hg during drug administration in 17 out of 20 @entity0 in group 1 ( @entity4 withdrawn in two) and in none out of 20 in group 2. Two @entity0 in group 1 developed transient @entity3 ( @entity4 withdrawn in one). None of 17 @entity0 in group 1 and two of 17 in group 2 relapsed temporarily into @entity2 during the 12 hours of intravenous treatment. On continued oral treatment, one late relapse occurred in group 1 and five in group 2, and five @entity0 in group 2 had @entity7 withdrawn because of anticholinergic side effects (acute urinary retention in four). @entity4 was as effective as the digoxin/ @entity7 combination and acted significantly faster. Sensitivity to beta blockade in these @entity0 may be related to high plasma @entity5 concentrations known to occur after cardiopulmonary bypass.

title: Intravenous @entity4 for the treatment of XXXX and @entity6 after cardiopulmonary bypass. Comparison with @entity7 and digoxin in a randomised trial.

answer: @entity2


abstract: The efficacy of @entity4 in treating acute @entity2 and @entity6 after open heart surgery was compared with that of a digoxin/ @entity7 combination. Forty adult @entity0 with postoperative @entity1 were randomised into either group 1 ( @entity4 1 mg/kg bolus intravenously plus 0.2 mg/kg intravenously over 12 hours) or group 2 (digoxin 0.75 mg intravenously, then two hours later @entity7 2 mg/kg intravenous bolus and 0.4 mg/kg/h intravenously for 10 hours). In each group, 17 out of 20 @entity0 reverted to sinus or junctional rhythm within 12 hours. The time to reversion in group 1 was significantly shorter than in group 2. Systolic blood pressure fell by greater than or equal to 20 mm Hg or to less than or equal to 90 mm Hg during drug administration in 17 out of 20 @entity0 in group 1 ( @entity4 withdrawn in two) and in none out of 20 in group 2. Two @entity0 in group 1 developed transient @entity3 ( @entity4 withdrawn in one). None of 17 @entity0 in group 1 and two of 17 in group 2 relapsed temporarily into @entity2 during the 12 hours of intravenous treatment. On continued oral treatment, one late relapse occurred in group 1 and five in group 2, and five @entity0 in group 2 had @entity7 withdrawn because of anticholinergic side effects (acute urinary retention in four). @entity4 was as effective as the digoxin/ @entity7 combination and acted significantly faster. Sensitivity to beta blockade in these @entity0 may be related to high plasma @entity5 concentrations known to occur after cardiopulmonary bypass.

title: Intravenous @entity4 for the treatment of @entity2 and @entity6 after cardiopulmonary bypass. Comparison with XXXX and digoxin in a randomised trial.

answer: @entity7


abstract: The efficacy of @entity4 in treating acute @entity2 and @entity6 after open heart surgery was compared with that of a digoxin/ @entity7 combination. Forty adult @entity0 with postoperative @entity1 were randomised into either group 1 ( @entity4 1 mg/kg bolus intravenously plus 0.2 mg/kg intravenously over 12 hours) or group 2 (digoxin 0.75 mg intravenously, then two hours later @entity7 2 mg/kg intravenous bolus and 0.4 mg/kg/h intravenously for 10 hours). In each group, 17 out of 20 @entity0 reverted to sinus or junctional rhythm within 12 hours. The time to reversion in group 1 was significantly shorter than in group 2. Systolic blood pressure fell by greater than or equal to 20 mm Hg or to less than or equal to 90 mm Hg during drug administration in 17 out of 20 @entity0 in group 1 ( @entity4 withdrawn in two) and in none out of 20 in group 2. Two @entity0 in group 1 developed transient @entity3 ( @entity4 withdrawn in one). None of 17 @entity0 in group 1 and two of 17 in group 2 relapsed temporarily into @entity2 during the 12 hours of intravenous treatment. On continued oral treatment, one late relapse occurred in group 1 and five in group 2, and five @entity0 in group 2 had @entity7 withdrawn because of anticholinergic side effects (acute urinary retention in four). @entity4 was as effective as the digoxin/ @entity7 combination and acted significantly faster. Sensitivity to beta blockade in these @entity0 may be related to high plasma @entity5 concentrations known to occur after cardiopulmonary bypass.

title: Intravenous XXXX for the treatment of @entity2 and @entity6 after cardiopulmonary bypass. Comparison with @entity7 and digoxin in a randomised trial.

answer: @entity4


abstract: PURPOSE: To identify potential biomarkers that may provide new therapeutic targets or prognostic indicators for @entity6 ( @entity6 ), we investigated the three-dimensional (3D) organization of telomeres and cytoband 17q25.3 copy number in @entity6 tissues. METHODS: @entity6 paraffin-embedded tissue specimens from 18 @entity0 were assessed for 3D telomere organization by 3D nuclear telomere imaging followed by quantitative analysis. @entity0 were stratified by smoking, histology, and @entity3 status. Cytoband 17q25.3 was examined by fluorescent in situ hybridization. Data from comparative genomic hybridization and/or single nucleotide polymorphism arrays for cytoband 17q25.3 were obtained and correlated with Q-FISH and 3D telomere results. RESULTS: 3D telomeric profiling demonstrated that the smokers, @entity3 -negative, and @entity4 subgroups tended to have higher numbers of lower-intensity telomeres, indicative of shorter telomeres, as well as higher numbers of @entity7 compared to non-smokers, @entity3 -positive, and @entity2 , respectively. Gains of cytoband 17q25.3 in conjunction with an increase in the control region 17p11.2 were observed in 7 of 18 (38.9  %) @entity0 , reflecting a @entity5 . Clonal gains of cytoband 17q25.3 were observed in 11 of 18 (61  %) @entity0 , highlighting a potential biological significance for the genes in this region in @entity6 tumourigenesis. CONCLUSIONS: The 3D telomere profiles may differentiate @entity6 @entity0 with different histologies, @entity3 , and smoking statuses, rendering them a potential biomarker for distinguishing these clinically relevant histological and molecular subtypes of @entity1 . Highly frequent clonal gain of cytoband 17q25.3 was also demonstrated, suggesting an important biological role for the genes in this region.

title: Assessment of the clinical relevance of 17q25.3 copy number and three-dimensional telomere organization in non-small XXXX @entity0 .

answer: @entity1


abstract: PURPOSE: To identify potential biomarkers that may provide new therapeutic targets or prognostic indicators for @entity6 ( @entity6 ), we investigated the three-dimensional (3D) organization of telomeres and cytoband 17q25.3 copy number in @entity6 tissues. METHODS: @entity6 paraffin-embedded tissue specimens from 18 @entity0 were assessed for 3D telomere organization by 3D nuclear telomere imaging followed by quantitative analysis. @entity0 were stratified by smoking, histology, and @entity3 status. Cytoband 17q25.3 was examined by fluorescent in situ hybridization. Data from comparative genomic hybridization and/or single nucleotide polymorphism arrays for cytoband 17q25.3 were obtained and correlated with Q-FISH and 3D telomere results. RESULTS: 3D telomeric profiling demonstrated that the smokers, @entity3 -negative, and @entity4 subgroups tended to have higher numbers of lower-intensity telomeres, indicative of shorter telomeres, as well as higher numbers of @entity7 compared to non-smokers, @entity3 -positive, and @entity2 , respectively. Gains of cytoband 17q25.3 in conjunction with an increase in the control region 17p11.2 were observed in 7 of 18 (38.9  %) @entity0 , reflecting a @entity5 . Clonal gains of cytoband 17q25.3 were observed in 11 of 18 (61  %) @entity0 , highlighting a potential biological significance for the genes in this region in @entity6 tumourigenesis. CONCLUSIONS: The 3D telomere profiles may differentiate @entity6 @entity0 with different histologies, @entity3 , and smoking statuses, rendering them a potential biomarker for distinguishing these clinically relevant histological and molecular subtypes of @entity1 . Highly frequent clonal gain of cytoband 17q25.3 was also demonstrated, suggesting an important biological role for the genes in this region.

title: Assessment of the clinical relevance of 17q25.3 copy number and three-dimensional telomere organization in non-small @entity1 XXXX .

answer: @entity0