abstract: UNASSIGNED: @entity4 ( @entity4 ) is one of the @entity1 in the world. Therefore, new therapeutic options are urgently needed to improve the survival of @entity4 @entity0 . Protein kinase G (PKG) conducts the interlude of @entity6 signaling which is important for healthy as well as for @entity1 cells. @entity9 is a specific inhibitor of PKG, and it has been shown to possess an anti- @entity1 cytotoxic activity in vitro. The main aim of this work was to investigate anti- @entity1 effects of @entity9 upon @entity4 in vivo.Expression of PKG was assessed with real-time PCR analysis in the normal and @entity1 pancreatic cells. In vitro cell viability, proliferation, apoptosis, @entity3 , migration, and invasion of the @entity2 @entity4 cell line Panc02 were assessed after @entity9 treatment. In vivo anti- @entity1 effects of @entity9 were investigated in the @entity2 Panc02 orthotopic model of @entity4 . Western blot analysis was used to determine the phosphorylation state of the proteins of interest.Functional PKGI is preferentially expressed in @entity4 cells. @entity9 was capable to reduce viability, proliferation, and migration of @entity2 @entity4 cells in vitro. At the same time, @entity9 treatment did not change the viability of normal epithelial cells of @entity2 liver. In vivo, @entity9 treatment reduced the @entity1 volume and metastases in @entity4 -bearing @entity2 , but it was ineffective to prolong the survival of the @entity1 -bearing animals. In addition, @entity9 treatment decreased phosphorylation of @entity7 , @entity5 , and @entity8 in @entity2 @entity4 .Inhibition of PKG could be a potential therapeutic strategy for @entity4 treatment which should be carefully validated in future pre-clinical studies.

title: Anti- XXXX properties of the @entity6 /protein kinase G inhibitor @entity9 in pancreatic adenocarcinoma.

answer: @entity1


abstract: OBJECTIVE: After mild and severe @entity1 , to assess whether @entity0 meet the physical activity recommendation at 3 and 6months postpartum, and whether demographic, obstetric and anthropometric characteristics, mental health, and health-related quality of life are associated with less physical activity than recommended. STUDY DESIGN: Prospective cohort study. MAIN OUTCOME MEASURES: Self-reported physical activity in MET-min/week, percentage of @entity0 who fail to meet the physical activity recommendation. METHODS: Of the 255 @entity0 diagnosed with @entity1 invited to participate in this prospective cohort study, 174 (68%) provided informed consent. Analyses were restricted to 141 @entity0 who completed the short form of the International Physical Activity Questionnaire at 3 and/or 6months postpartum. Logistic regression analysis was used to evaluate changes in physical activity level over time, and to establish which variables were associated with failure to meet the postpartum physical activity recommendation. RESULTS: At both 3 and 6months postpartum, 38% of @entity0 failed to meet the physical activity recommendation. Failure was associated with severe @entity1 , cesarean section, admission to the neonatal intensive care unit, low gestational age at delivery, and low birth weight (all p<0.05). CONCLUSIONS: There seems to be a need to stimulate physical activity in about one third of @entity0 after a pregnancy complicated by @entity1 , particularly in case of severe @entity1 and other adverse pregnancy outcomes. Tailored lifestyle interventions are needed for @entity0 who fail to meet the recommendation.

title: Postpartum physical activity after XXXX .

answer: @entity1


abstract: INTRODUCTION: @entity5 is known to be a major cause of pregnancy complications, such as @entity1 , @entity3 , and @entity4 ( @entity4 ). Inadequate remodeling of the spiral arteries resulting in decreased blood flowto the placenta has been implicated in the pathophysiology of @entity3 and @entity4 . 3D power Doppler angiography (PDA) is a noninvasive and safe way to study blood flow within an organ or region of interest. The aim of this study was to evaluate PDA as a method to quantify placental perfusion in a pharmacological @entity0 model of vascular @entity4 induced by inhibition of NO synthesis. OBJECTIVES: Our objective was to evaluate the 3D power Doppler angiography (PDA) in terms of feasibility and ability to detect placental hypo-perfusion in an experimental @entity0 model of @entity4 ( @entity4 ). METHODS: Fourteen pregnant females were treated with @entity7 ( @entity7 ), a @entity2 synthase inhibitor, from day 24 to day 28 of gestation, to induce an @entity4 . Concomitantly, 8 pregnant @entity0 were used as controls. On day 28, 3D power Doppler indices were quantified in each uteroplacental unit. RESULTS: A total number of 180 live fetuses were obtained, 180 from the @entity7 group and 72 from the control group. G28 fetal weight was significantly lower in the @entity7 group than in the control group (27.40  0.55g vs 33.14  0.62g,p<0.0001). In the @entity7 group the vascularization index (VI) was significantly lower than in the control group (2.6 [1.4;6.0] vs 7.6 [3.5;12.6],p<0.05). Similar results were obtained for the Flow Index (FI) and the Vascularization Flow Index (VFI). The number of fetuses considered as small for gestational age (SGA;weight<10th centile) was significantly higher in the @entity7 group than in the control group (47/108 vs 7/72,p<0.0001). The VI was significantly lower in the SGA group than in the eutrophic group (3.46 [0.46;5.9] vs 7.50 [4.22;10.9] p<0.05). Similar results were obtained for FI and VFI. CONCLUSIONS: This experiment study demonstrates that quantitative 3D PDA indices are sensitive enough to detect placental @entity6 in an experimental model of @entity4 .

title: OS047. Quantification of placental vascularization in a XXXX model ofIUGR with three-dimensional power doppler angiography.

answer: @entity0


abstract: INTRODUCTION: Previously preeclamptic @entity0 may express @entity1 , which have largely been ignored or attributed to the stresses of a complicated pregnancy. OBJECTIVES: This study aimed to identify the scope of neurocognitive and @entity4 following @entity3 . METHODS: Through website promotion and a mass e-mail members of the USA-based Preeclampsia Foundation who experienced @entity3 in the past 20 years were invited to complete a web-based survey, consisting of a questionnaire about current and past medical health, the Cognitive Failures Questionnaire (CFQ), the abbreviated WHO Quality Of Life questionnaire (WHOQOL-BREF), and the Social Functioning Questionnaire (SFQ). @entity0 were stimulated to ask a friend who had a normotensive pregnancy to complete the survey as well (controls). @entity0 with current or past neurological conditions were excluded. Analysis was performed using Mann Whitney U test and linear regression. RESULTS: 966 cases and 342 controls were included. Median age was 34, median time since first pregnancy 4 and 5 years respectively. Cases scored significantly worse on all three questionnaires, and more often underwent @entity2 therapy, currently or in the past. There was a significant effect of @entity5 on all questionnaires and of @entity6 on CFQ score. Cronbach's alphas were >0.7, indicating good internal consistency of the questionnaires. Results are expressed as median (range) or number (percentage) (   )p<.001. CONCLUSION: Previously preeclamptic @entity0 report more @entity1 , and worse quality of life compared to @entity0 who had normotensive pregnancies. Health care providers and @entity0 should be aware of this so that affected @entity0 may receive recognition, psychological care and escape from the ignorance of their environment. Our findings may stimulate research relating to the origin and management of these important issues.

title: OS101. The brain study: cognition, quality of life and social functioning following XXXX .

answer: @entity3


abstract: BACKGROUND: @entity1 is associated with mobility reduction due to mechanical factors and excessive body fat. The six-minute walk test (6MWT) has been used to assess functional capacity in severe @entity1 . OBJECTIVE: To determine the association of BMI, @entity2 with distance walked (6MWD) during the six-minute walk test (6MWT) according to gender and @entity1 grade. SETTING: University of S  o Paulo Medical School, Brazil; Public Practice. METHODS: Functional capacity was assessed by 6MWD and body composition (%) by bioelectrical impedance analysis in 90 @entity0 . RESULTS: The mean 6MWD was 514.9    50.3 m for both genders. The male group (M: 545.2    46.9 m) showed a 6MWD higher (p = 0.002) than the female group (F: 505.6    47.9 m). The morbid obese group (MO: 524.7    44.0 m) also showed a 6MWD higher (p = 0.014) than the super obese group (SO: 494.2    57.0 m). There was a positive relationship between 6MWD and @entity3 ( @entity3 ), @entity3 of upper limps (FFM_UL), trunk (FFM_TR) and lower limbs (FFM_LL). Female group presented a positive relationship between 6MWD and @entity3 , FFM_UL and FFM_LL and male group presented a positive relationship between 6MWD and FFM_TR. In morbid obese group there was a positive relationship between 6MWD with @entity3 , FFM_UL, FFM_TR and FFM_LL. The super obese group presented a positive relationship between 6MWD with @entity3 , FFM_TR and FFM_LL. CONCLUSIONS: Total and segmental @entity3 is associated with a better walking capacity than BMI.

title: Correlation between Body Composition and Walking Capacity in Severe XXXX .

answer: @entity1


abstract: BACKGROUND: The prevalence of @entity1 ( @entity1 ) for astronauts in space (68%) is higher than the 1-mo prevalence for the general population on Earth (39%). It is unclear whether differences occur between healthy subjects and astronauts with a history of @entity1 . Knowledge of this issue is important to assess whether a history of @entity1 could have an operational impact. METHODS: We evaluated @entity1 prospectively during short duration spaceflight (15 d; N = 20) and compared this with similar data collected during two bed rest studies (N = 40). Astronauts completed a questionnaire 5-10 d preflight, during each flight day, and 5-10 d postflight. RESULTS: All astronauts with a history of @entity1 also developed @entity1 in flight. These astronauts reported a significantly longer duration of @entity1 and a different @entity0 location. @entity1 was most often experienced in the central area of the lower back during spaceflight with an incidence of 70% and a mean @entity0 level of 3 (on a scale of 0-10). @entity0 resolved within 10 d of flight. No neurological signs were present. The most frequently reported countermeasure was assuming a "knees to chest (fetal tuck) position" combined with stretching. Greater @entity1 intensity was reported in spaceflight than bed rest with a trend indicating a greater number of days of @entity0 during spaceflight. DISCUSSION: The current study represents a prospective study of @entity1 in spaceflight. The results indicate that @entity1 is self-limiting in spaceflight and should not pose an operational risk. Prior @entity1 on Earth appears to be a risk factor for @entity1 in spaceflight. Pool-Goudzwaard AL, Belav   DL, Hides JA, Richardson CA, Snijders CJ. @entity1 in microgravity and bed rest studies. Aerosp Med Hum Perform. 2015; 86(6):541-547.

title: Low Back XXXX in Microgravity and Bed Rest Studies.

answer: @entity0


abstract: BACKGROUND: We aimed to establish a @entity2 biobank to serve as a resource for clinical and biomarker studies of disease risk and treatment response. Here, we describe the aims, design, infrastructure, and research uses of the biobank, along with demographics and clinical features of the first @entity0 enrolled. METHODS: @entity0 were recruited for the Mayo Clinic Bipolar Biobank beginning in July 2009. The Structured Clinical Interview for DSM-IV was used to confirm @entity2 . The Bipolar Biobank Clinical Questionnaire and @entity0 Questionnaire were designed to collect detailed demographic and clinical data, including clinical @entity3 measures that would delineate differential phenotypes for subsequent analyses. Blood specimens were obtained from @entity0 , and various aliquots were stored for future research. RESULTS: As of September 2014, 1363 @entity0 have been enrolled in the bipolar biobank. Among these first @entity0 , 69.0  % had a diagnosis of @entity2 type I. The group was 60.2  % @entity0 and predominantly white (90.6  %), with a mean (SD) age of 42.6 (14.9) years. Clinical phenotypes of the group included history of @entity5 (42.3  %), suicide attempt (32.5  %), addiction to @entity4 (39.1  %), addiction to @entity7 (39.8  %), @entity1 (42.9  %), @entity9 -induced @entity2 (31.7  %), @entity6 (3.2  %), and history of drug-related serious @entity8 (5.7  %). CONCLUSIONS: Quantifying phenotypic patterns of illness beyond bipolar subtype can provide more detailed clinical disease characteristics for biomarker research, including genomic-risk studies. Future research can harness clinically useful biomarkers using state-of-the-art research technology to help stage disease burden and better individualize treatment selection for @entity0 with @entity2 .

title: Development of a XXXX biobank: differential phenotyping for subsequent biomarker analyses.

answer: @entity2


abstract: Seventy-six cases of @entity4 of the supraglottic larynx treated by radiotherapy exclusively and followed for at least 3 years are reported. High doses, close to the maximum tolerable, were used with the shrinking field technique with no attempt at prophylactic whole neck irradiation. T1 and T2 cases represented 40% of the whole group and 40% of the @entity0 presented clinically positive @entity3 . This latter group had a significantly lower cure rate (42.8%) than the N0 @entity0 (88.3%). Disease control depended also on the T stage: all 30 T1 and T2 lesions, 18/22 (81.8%) of the T3, and 6/17 (35.3%) of the T4 lesions were controlled. Cord fixation and early cartilage destruction were not a major obstacle for @entity1 control. Base of tongue involvement and especially the T4 and N3 association were indications of poor prognosis. Adenopathies smaller than 3 cm were controlled in 14/16 cases while nodes greater than or equal to 3 cm were controlled in 5/11 cases. Failures in neck nodes outside the treatment field were encountered in 7% of the cases but as the sole element of failure they represented 5.6%. Absolute survival at 3 years was 69.7% for the whole series while loco-regional control was 74.6%. No @entity0 was salvaged by surgery. Three loco-regional recurrences occurred 3 years after the treatment. Although no lethal complications were encountered severe late reactions were noted in about 20% of the @entity0 with controlled @entity2 , requiring tracheostomy in 4 cases (7%). Treatment guidelines are suggested: T1, T2, _ T3 lesions associated with @entity5 smaller than 3 cm should be treated by radiotherapy. Limited extra laryngeal extension especially to cartilage can still be controlled by irradiation. More advanced cases, especially the subcategory of T4 N3 @entity0 , should have a multidisciplinary approach. After high doses of irradiation only limited surgery is permissible.

title: XXXX of the supraglottic larynx treated by radiotherapy exclusively.

answer: @entity1


abstract: Sufficient antigen retention in joint structures is a prerequisite for sustained antigen-induced @entity4 . In this in vitro study we investigated the retention of native and charge-modified bovine serum albumin (BSA) with patellar cartilage of different species ( @entity1 , @entity2 , @entity3 , and @entity0 ). Association of BSA with cartilage due to charge of the protein with that due to immune complex formation was compared. Using radiolabeled proteins we showed quantitatively that the retention of highly positively charged BSA is considerably higher (200-500 times) than retention of the anionic BSA in all cartilage species examined. @entity1 , @entity2 , and @entity0 cartilage bind more protein per mg dry weight, compared to @entity3 cartilage. No clear-cut relation was found with the glycosaminoglycans (GAG) contents. Retention of native BSA by anti-BSA antibodies was low in the dense hyaline patellar cartilage in all species. Enhanced immune-complex formation was found in marginal regions of @entity3 patellar cartilage, consisting of fibrous-like cartilage. Localization studies by autoradiography showed that cationic BSA penetrates deeply into the cartilage matrix. Even in a thick cartilage specimen, such as @entity3 cartilage, very deep penetration into the calcified zone was demonstrated. This study indicates that binding and deep penetration of cationized protein in cartilage is not restricted to @entity1 specimen, as had been found previously, but is a general phenomenon.

title: Electrical charge of a protein determines penetration and localization in hyaline articular cartilage. Quantitative and autoradiographic studies on cartilage of different species, including XXXX .

answer: @entity0


abstract: Daily doses of ENU (25-100 mg/kg) were injected intraperitoneally into ICR strain male @entity0 for 5 days. The males were mated to untreated virgin females of the same strain on days 1-16 and 64-80 after the last dose. Copulations during these periods involve, respectively, treated postmeiotic cells and spermatogonial stem cells. The uterine contents were examined on day 18 of pregnancy for evidence of dominant lethal effects. The fetuses were examined for external and @entity2 . ENU treatment of either postmeiotic cells or spermatogonial stem cells caused dose-dependent significant increases in the incidence of abnormal fetuses over the control level. The induction rate per live fetus per unit dose in mg/kg by treating spermatogonial stem cells was estimated to be 1.0 X 10(-4), which is 3-fold lower than the rate previously estimated for the same endpoint at the same germ cell stage with @entity4 . @entity3 was the most frequent external abnormality in the ENU-treated and the control series. Malformed vertebrae was the most frequent @entity2 in the treated series. Rib fusion was the only @entity1 seen in the control series. Dominant lethals were clearly induced when germ cells were treated as postmeiotic cells.

title: Congenital defects in the offspring of male XXXX treated with ethylnitrosourea.

answer: @entity0


abstract: OBJECTIVES: The aim of this retrospective study was to correlate the significance and accuracy of the colour of nipple discharge and breast ultrasound imaging in the diagnosis of @entity2 . METHODS: This is a retrospective study of 34 @entity0 who underwent 36 microdochectomies in Sultan Qaboos University Hospital (SQUH) in the Sultanate of Oman, over a 4 year period of January 2009 till December 2012. The confounders considered were @entity0 age, physical examination findings, nipple discharge cytology result, ultrasound results and biopsy report following microdochectomy. Comparisons analysis, charts and graphs were made using the SPSS software (version 20). RESULTS: The mean age of the @entity0 was 44(27-73) years old. Twenty-seven out 36 (75%) @entity0 had presented with nipple discharge, 14 out 27 (52%) had blood stained nipple discharge and 13(48%) with coloured discharge (yellow, brown and green), 9 @entity0 had no discharge. The final histopathology showed @entity2 13 (36%), duct ectasia 18(50%), DCIS 1 (2.7%), @entity1 3(8.3%) and LCIS 1(2.7%). Thirteen out of 36 had @entity2 on final histopathology. The correlation between blood stained discharge and final histopathology of @entity2 was insignificant (p=0.44). CONCLUSION: Nipple discharge is irrelevant to the diagnosis of @entity2 . Spontaneous nipple discharge regardless of color is to be referred to breast surgeon and to be assessed with triple assessment. Surgery remains the mainstay of treatment.

title: Diagnostic dilemmas in XXXX of the breast - Experience at Sultan Qaboos University Hospital in the Sultanate of Oman.

answer: @entity2


abstract: Drugs are a significant cause of @entity1 . @entity1 ( @entity1 ) can cause acute @entity1 , @entity4 , or a mixed pattern. @entity5 is a commonly used antibiotic and has been associated with reversible @entity2 , pseudolithiasis, and @entity4 . A 32-year-old male with @entity6 was admitted to the hospital for acute sickle cell crisis. On the second day of hospitalization, he developed cough and rhonchi with chest X-ray revealing right middle lobe infiltrates. @entity5 and @entity8 were initiated. Subsequently, he developed conjugated @entity7 and mild transaminitis. His total @entity3 trended upwards from 3.3   mg/dL on admission to 17   mg/dL. It was predominantly conjugated @entity3 , with preadmission @entity3 levels of 3-4   mg/dL. His transaminases were mildly elevated as well compared to previous levels. Extensive workup for @entity3 elevation was unremarkable. @entity5 was switched to @entity9 and the @entity7 improved. On ambulatory follow-up, his @entity3 remained below 4   mg/dL. @entity5 may be associated with marked direct @entity7 particularly in sickle cell @entity0 with chronic liver chemistry abnormalities. In the case of elevated @entity3 with concomitant @entity5 use, elimination of the offending agent should be considered.

title: Marked Direct @entity7 due to XXXX in an Adult with @entity6 .

answer: @entity5


abstract: Drugs are a significant cause of @entity1 . @entity1 ( @entity1 ) can cause acute @entity1 , @entity4 , or a mixed pattern. @entity5 is a commonly used antibiotic and has been associated with reversible @entity2 , pseudolithiasis, and @entity4 . A 32-year-old male with @entity6 was admitted to the hospital for acute sickle cell crisis. On the second day of hospitalization, he developed cough and rhonchi with chest X-ray revealing right middle lobe infiltrates. @entity5 and @entity8 were initiated. Subsequently, he developed conjugated @entity7 and mild transaminitis. His total @entity3 trended upwards from 3.3   mg/dL on admission to 17   mg/dL. It was predominantly conjugated @entity3 , with preadmission @entity3 levels of 3-4   mg/dL. His transaminases were mildly elevated as well compared to previous levels. Extensive workup for @entity3 elevation was unremarkable. @entity5 was switched to @entity9 and the @entity7 improved. On ambulatory follow-up, his @entity3 remained below 4   mg/dL. @entity5 may be associated with marked direct @entity7 particularly in sickle cell @entity0 with chronic liver chemistry abnormalities. In the case of elevated @entity3 with concomitant @entity5 use, elimination of the offending agent should be considered.

title: Marked Direct XXXX due to @entity5 in an Adult with @entity6 .

answer: @entity7


abstract: Drugs are a significant cause of @entity1 . @entity1 ( @entity1 ) can cause acute @entity1 , @entity4 , or a mixed pattern. @entity5 is a commonly used antibiotic and has been associated with reversible @entity2 , pseudolithiasis, and @entity4 . A 32-year-old male with @entity6 was admitted to the hospital for acute sickle cell crisis. On the second day of hospitalization, he developed cough and rhonchi with chest X-ray revealing right middle lobe infiltrates. @entity5 and @entity8 were initiated. Subsequently, he developed conjugated @entity7 and mild transaminitis. His total @entity3 trended upwards from 3.3   mg/dL on admission to 17   mg/dL. It was predominantly conjugated @entity3 , with preadmission @entity3 levels of 3-4   mg/dL. His transaminases were mildly elevated as well compared to previous levels. Extensive workup for @entity3 elevation was unremarkable. @entity5 was switched to @entity9 and the @entity7 improved. On ambulatory follow-up, his @entity3 remained below 4   mg/dL. @entity5 may be associated with marked direct @entity7 particularly in sickle cell @entity0 with chronic liver chemistry abnormalities. In the case of elevated @entity3 with concomitant @entity5 use, elimination of the offending agent should be considered.

title: Marked Direct @entity7 due to @entity5 in an Adult with XXXX .

answer: @entity6


abstract: Two hundred and fifty-five neonates, @entity0 and @entity0 , from 45 hospitals, who were receiving @entity5 therapy for serious infections were the subject of this study. Samples of serum and cerebrospinal fluid (CSF) were assayed for @entity5 and the @entity0 ' treatment regimens analysed. Less than 50% of neonates and 25% of @entity0 received the "recommended" dose of @entity5 . In older @entity0 the recommended dose was used. Only 34% babies under 1 year of age and 50% older children had serum concentrations within the therapeutic range (15-25 mg/l). Thirty-one percent of neonates and @entity0 had potentially toxic serum concentrations. Forty-three percent of neonates receiving @entity5 every 6 h had subtherapeutic peak serum levels compared to 20% of those receiving the antibiotic every 12 h. Concomitant administration of @entity2 or @entity6 had no effect on mean serum @entity5 levels. Serum concentrations of @entity5 were significantly higher in @entity0 also receiving @entity3 . CSF levels in 77 samples (39 @entity0 ) ranged from 1-60 mg/l. CSF from 44% @entity0 contained less than 4 mg/l. Twelve neonates and @entity0 (5.5%) suffered toxic side effects, four died. A further eight babies received an accidental 2- to 10-fold @entity4 and in three others an @entity4 was assumed following assay. No @entity4 or toxic effects were reported in @entity0 over 1 year of age. Eight @entity0 with @entity1 had elevated serum levels and three showed toxic effects. In 22% @entity0 dosage regimens were altered following assay.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX in paediatrics: current prescribing practice and the need to monitor.

answer: @entity5


abstract: @entity4 of the pelvic girdle represent difficult treatment problems. Many are not treatable for cure, and among the @entity0 who are technically resectable, there is high risk for @entity2 recurrence and distant spread. Intraoperative radiotherapy (IORT) has been used in conjunction with surgical resection in five @entity0 with extensive @entity4 of the pelvic girdle. @entity0 underwent a hemipelvectomy and IORT (dose 20-30 Gy) to the sacral resection margin and surrounding soft tissues. Three @entity0 developed pulmonary @entity1 within 3 months and eventually died from metastatic disease (8-38 months). Two @entity0 have remained disease-free (43 and 53 months). Four @entity0 (80%) have remained locally free of @entity2 with follow-ups of 8-53 months. The only treatment complication was late @entity5 of the coccyx which appeared 7 months after treatment. By contrast, six historical control @entity0 with @entity4 of the pelvic girdle treated with resection alone showed a local control rate of only 27% over a 40-month follow-up. On the basis of this preliminary experience, it appears that IORT may substantially help to control @entity3 in @entity0 with grossly resectable @entity4 of the bony pelvis.

title: Surgery with intraoperative radiotherapy for XXXX of the pelvic girdle: a pilot experience.

answer: @entity4


abstract: AIM: This study compared the operative outcome and long-term survival of three types of hand-sewn @entity2 ( @entity2 ) for @entity1 . METHOD: @entity0 presenting with @entity1 at a single centre between 2006 and 2014 were classified into three types of hand-sewn @entity2 : type 1 (supra-anal @entity1 undergoing transabdominal division of the rectum with transanal mucosectomy); type 2 (juxta-anal @entity1 , undergoing partial intersphincteric resection); and type 3 (intra-anal @entity1 , undergoing near-total intersphincteric resection with transanal mesorectal excision). RESULTS: Seventy-one @entity0 with @entity1 underwent @entity2 : 17 type 1; 39 type 2; and 15 type 3. The median age of @entity0 was 61.6  years, with a male/female ratio of 2:1. Neoadjuvant therapy was given to 56 (79%) @entity0 . R0 resection was achieved in 69 (97.2%) @entity0 . Adverse events occurred in 25 (35.2%) of the 71 @entity0 with a higher complication rate in type 1 vs type 2 vs type 3 (47.1% vs 38.5% vs 13.3%, respectively; P  =  0.035). @entity3 was identified in six (8.5%) @entity0 and pelvic haematoma/ @entity4 in five (7%); two (8.3%) female @entity0 developed a @entity5 . Ten (14.1%) @entity0 were indefinitely diverted, with a trend towards higher long-term anastomotic failure in type 1 vs type 2 vs type 3 (17.6% vs 15.5% vs 6.7%). The type of @entity2 did not influence the overall or disease-free survival. CONCLUSION: @entity2 is a safe technique in which anorectal continuity can be preserved either as a primary restorative option in elective cases of @entity1 or as a salvage procedure following a failed stapled @entity2 with a less successful outcome in the latter. @entity2 has acceptable morbidity with good long-term survival in carefully selected @entity0 .

title: Hand-sewn XXXX for @entity1 : technique and long-term outcome.

answer: @entity2


abstract: AIM: This study compared the operative outcome and long-term survival of three types of hand-sewn @entity2 ( @entity2 ) for @entity1 . METHOD: @entity0 presenting with @entity1 at a single centre between 2006 and 2014 were classified into three types of hand-sewn @entity2 : type 1 (supra-anal @entity1 undergoing transabdominal division of the rectum with transanal mucosectomy); type 2 (juxta-anal @entity1 , undergoing partial intersphincteric resection); and type 3 (intra-anal @entity1 , undergoing near-total intersphincteric resection with transanal mesorectal excision). RESULTS: Seventy-one @entity0 with @entity1 underwent @entity2 : 17 type 1; 39 type 2; and 15 type 3. The median age of @entity0 was 61.6  years, with a male/female ratio of 2:1. Neoadjuvant therapy was given to 56 (79%) @entity0 . R0 resection was achieved in 69 (97.2%) @entity0 . Adverse events occurred in 25 (35.2%) of the 71 @entity0 with a higher complication rate in type 1 vs type 2 vs type 3 (47.1% vs 38.5% vs 13.3%, respectively; P  =  0.035). @entity3 was identified in six (8.5%) @entity0 and pelvic haematoma/ @entity4 in five (7%); two (8.3%) female @entity0 developed a @entity5 . Ten (14.1%) @entity0 were indefinitely diverted, with a trend towards higher long-term anastomotic failure in type 1 vs type 2 vs type 3 (17.6% vs 15.5% vs 6.7%). The type of @entity2 did not influence the overall or disease-free survival. CONCLUSION: @entity2 is a safe technique in which anorectal continuity can be preserved either as a primary restorative option in elective cases of @entity1 or as a salvage procedure following a failed stapled @entity2 with a less successful outcome in the latter. @entity2 has acceptable morbidity with good long-term survival in carefully selected @entity0 .

title: Hand-sewn @entity2 for XXXX : technique and long-term outcome.

answer: @entity1


abstract: Life cycle adaptation to seasonal variation in photoperiod and temperature is a major determinant of ecological success of widespread domestication of @entity0 . The circadian clock plays a role in the underlying mechanism for adaptation. Nevertheless, the mechanism by which the circadian clock tracks seasonal changes in photoperiod and temperature is a longstanding subject of research in the field. We previously showed that a set of the target genes (i.e. GI, LNK1. @entity4 and @entity3 ) of the Evening Complex (EC) consisting of LUX- @entity2 - @entity5 is synergistically induced in response to both warm-night and night-light signals. Here, we further show that the responses occur within a wide range of growth-compatible temperatures (16-28  C) in response to a small change in temperature (/\4  C). A dim light pulse (<1   mol m(-2) s(-1)) causes the enhanced effect on the transcription of EC targets. The night-light pulse antagonizes against a positive effect of the cool-night signal on the EC activity. The mechanism of double-checking external temperature and light signals through the EC nighttime repressor might enable plants to ignore (or tolerate) daily fluctuation of ambient temperature within a short time interval in their natural habitats. Taken together, the EC night-time repressor might play a physiological role in tracking seasonal variation in photoperiod and temperature by conservatively double-checking both the light and temperature conditions. Another EC target output gene @entity1 regulating plant morphologies is also regulated by both the temperature and light stimuli during the night. Hence, the EC night-time repressor is also implicated in a physiological output of the @entity1 -mediated regulation of morphologies in response to seasonal variation in photoperiod and ambient temperature.

title: Insight into a Physiological Role for the EC Night-Time Repressor in the XXXX Circadian Clock.

answer: @entity0


abstract: Previous investigators have shown evidence of hormonal receptor protein in @entity0 @entity10 . In spite of conflicting results, antiestrogen agents (e.g., @entity7 ) have been used in clinical trials of recurrent unresectable @entity12 . In an effort to accrue further comprehensive in vitro data on this subject, we have evaluated 50 @entity0 brain and @entity1 for @entity4 , @entity11 , and @entity6 receptor markers. Twenty-nine of the 50 @entity1 were @entity12 . The other 21 included 11 @entity2 of various grades, 5 @entity8 , 3 metastatic @entity5 , 1 @entity13 , and 1 @entity9 . Only 8 @entity1 , all @entity12 , were positive for both @entity11 and @entity6 receptors. The 8th @entity1 was positive for all three receptor proteins. Our study did not find a significant relationship between @entity12 and the presence of @entity3 receptor protein. We conclude that the use of antiestrogen agents is not indicated in the treatment of @entity12 . No significant relationship to sex, menopausal status, @entity1 type, or @entity1 location was observed.

title: XXXX receptors in @entity0 brain and spinal cord tumors.

answer: @entity3


abstract: Previous investigators have shown evidence of hormonal receptor protein in @entity0 @entity10 . In spite of conflicting results, antiestrogen agents (e.g., @entity7 ) have been used in clinical trials of recurrent unresectable @entity12 . In an effort to accrue further comprehensive in vitro data on this subject, we have evaluated 50 @entity0 brain and @entity1 for @entity4 , @entity11 , and @entity6 receptor markers. Twenty-nine of the 50 @entity1 were @entity12 . The other 21 included 11 @entity2 of various grades, 5 @entity8 , 3 metastatic @entity5 , 1 @entity13 , and 1 @entity9 . Only 8 @entity1 , all @entity12 , were positive for both @entity11 and @entity6 receptors. The 8th @entity1 was positive for all three receptor proteins. Our study did not find a significant relationship between @entity12 and the presence of @entity3 receptor protein. We conclude that the use of antiestrogen agents is not indicated in the treatment of @entity12 . No significant relationship to sex, menopausal status, @entity1 type, or @entity1 location was observed.

title: @entity3 receptors in XXXX brain and spinal cord tumors.

answer: @entity0


abstract: UNASSIGNED: Decompressive craniectomy has been widely used in head @entity4 @entity0 . The randomized clinical trial on an early decompression (DECRA) demonstrated that craniectomy did not improve the neurological outcome, in contrast to previous animal experiments. The goal of our study was to analyze the effect of decompressive craniectomy in a @entity3 model of @entity5 . Male @entity3 were assigned into the following groups: sham, decompressive craniectomy, @entity10 ( @entity10 ) and @entity10 followed by craniectomy. At 24h posttrauma animals were subjected to Neurological Severity Score test (NSS) and Beam Balance Score test (BBS). At the same time point magnetic resonance imaging was performed and volume of @entity1 and @entity9 was assessed, followed by histopathological analysis. According to NSS, animals subjected to both @entity4 and craniectomy presented the most severe @entity2 . Also balancing time was reduced in this group compared to sham animals. Both @entity1 and @entity9 volume was increased in @entity4 and craniectomy group compared to sham animals. Histopathological analysis showed that all animals subjected to @entity4 presented substantial neuronal loss. In animals treated with craniectomy after @entity4 , a massive increase of @entity1 with @entity6 was documented. Decompressive craniectomy applied after @entity10 in @entity3 leads to additional @entity7 . The surgical decompression via craniectomy promotes @entity8 formation and contusional blossoming in our model. This additive effect of combined mechanical and surgical @entity4 may explain the results of DECRA trial and should be further explored in experiments.

title: Decompressive Craniectomy increases Brain Lesion Volume and exacerbates Functional Impairment in XXXX in @entity3 .

answer: @entity10


abstract: UNASSIGNED: Decompressive craniectomy has been widely used in head @entity4 @entity0 . The randomized clinical trial on an early decompression (DECRA) demonstrated that craniectomy did not improve the neurological outcome, in contrast to previous animal experiments. The goal of our study was to analyze the effect of decompressive craniectomy in a @entity3 model of @entity5 . Male @entity3 were assigned into the following groups: sham, decompressive craniectomy, @entity10 ( @entity10 ) and @entity10 followed by craniectomy. At 24h posttrauma animals were subjected to Neurological Severity Score test (NSS) and Beam Balance Score test (BBS). At the same time point magnetic resonance imaging was performed and volume of @entity1 and @entity9 was assessed, followed by histopathological analysis. According to NSS, animals subjected to both @entity4 and craniectomy presented the most severe @entity2 . Also balancing time was reduced in this group compared to sham animals. Both @entity1 and @entity9 volume was increased in @entity4 and craniectomy group compared to sham animals. Histopathological analysis showed that all animals subjected to @entity4 presented substantial neuronal loss. In animals treated with craniectomy after @entity4 , a massive increase of @entity1 with @entity6 was documented. Decompressive craniectomy applied after @entity10 in @entity3 leads to additional @entity7 . The surgical decompression via craniectomy promotes @entity8 formation and contusional blossoming in our model. This additive effect of combined mechanical and surgical @entity4 may explain the results of DECRA trial and should be further explored in experiments.

title: Decompressive Craniectomy increases Brain Lesion Volume and exacerbates Functional Impairment in @entity10 in XXXX .

answer: @entity3


abstract: OBJECTIVES: @entity5 , a common @entity1 in soft tissue, continues to grow, so it often appears to be giant. Surgical management of @entity5 is a challenge due to the risk of excessive @entity3 . @entity6 's nutrient artery may reduce the @entity2 in operation. This study introduces the surgical management of giant scalp @entity5 with preoperative ultra-selective embolization of nutrient artery. METHODS: From January 2006 to December 2013, 9 @entity0 with giant scalp @entity5 were enrolled into the study. Digital subtraction angiography (DSA) showed @entity1 's nutrient artery. Ultra-catheter was inserted into the nutrient artery and its branches as close as possible to the @entity1 . Then ultra-selective embolization was performed with gelatin sponge particles. Surgical @entity1 was performed in 3 days after embolization. The wound was repaired by skin graft. RESULTS: All of the 9 @entity0 underwent successful DSA and ultra-selective embolization. Among them, occipital artery was embolized in 3 @entity0 (left side in 1 @entity0 and right side in 2 @entity0 ). Both occipital artery and superficial temporal artery were embolized in 6 @entity0 (left side in 2 @entity0 , right side in 3 @entity0 , and both side in 1 @entity0 ). No complications, such as @entity4 , occurred in the @entity0 . All of the @entity1 were resected completely without blood transfusion. The skin graft survived very well on the wounds. CONCLUSIONS: Preoperative ultra-selective embolization of nutrient artery is a feasible, safe, and effective method to reduce the @entity2 in operation and facilitate the surgical management of giant scalp @entity5 .

title: Surgical Management of Giant Scalp XXXX After Ultra-Selective Embolization of Nutrient Artery.

answer: @entity5


abstract: PURPOSE: To compare the short-term results of the efficacy and safety of @entity2 intravitreal implant (DEX), ranibizumab (RAN), and intravitreal @entity6 (IVTA) in @entity4 secondary to branch @entity5 (BRVO). METHODS: One eye each of 32 @entity0 who were treated with intravitreal injections for @entity4 secondary to BRVO was studied. This retrospective study included 3 groups. The @entity0 received DEX in group 1 (n = 11), RAN in group 2 (n = 11), and IVTA in group 3 (n = 10). Data were collected before and after the injections at the first and third months. Best-corrected visual acuity (BCVA), @entity3 ( @entity3 ), and intraocular pressure (IOP) were analyzed statistically. RESULTS: The median duration of the follow-up was 3.0 months in overall groups. The BCVA increased significantly in all groups (p = 0.018, p = 0.034, p = 0.014, respectively). The @entity3 increased significantly in groups 1 and 3 (p = 0.02, plt;0.001, respectively), but not in group 2 (p = 0.14). The IOP increased significantly in groups 1 and 3 (p = 0.05, plt;0.001, respectively). Antiglaucomatous treatment was required only in group 3. @entity1 developed in 2 @entity0 (20%) in group 3 and surgery was required. CONCLUSIONS: Although RAN was the safest among the 3 agents, @entity7 and IVTA reduced @entity3 more than RAN, while significant improvement was achieved in BCVA in all groups. All 3 agents can be effectively used in the treatment of @entity4 due to BRVO.

title: Early results of XXXX implant, ranibizumab, and triamcinolone in @entity4 due to branch @entity5 .

answer: @entity2


abstract: PURPOSE: To compare the short-term results of the efficacy and safety of @entity2 intravitreal implant (DEX), ranibizumab (RAN), and intravitreal @entity6 (IVTA) in @entity4 secondary to branch @entity5 (BRVO). METHODS: One eye each of 32 @entity0 who were treated with intravitreal injections for @entity4 secondary to BRVO was studied. This retrospective study included 3 groups. The @entity0 received DEX in group 1 (n = 11), RAN in group 2 (n = 11), and IVTA in group 3 (n = 10). Data were collected before and after the injections at the first and third months. Best-corrected visual acuity (BCVA), @entity3 ( @entity3 ), and intraocular pressure (IOP) were analyzed statistically. RESULTS: The median duration of the follow-up was 3.0 months in overall groups. The BCVA increased significantly in all groups (p = 0.018, p = 0.034, p = 0.014, respectively). The @entity3 increased significantly in groups 1 and 3 (p = 0.02, plt;0.001, respectively), but not in group 2 (p = 0.14). The IOP increased significantly in groups 1 and 3 (p = 0.05, plt;0.001, respectively). Antiglaucomatous treatment was required only in group 3. @entity1 developed in 2 @entity0 (20%) in group 3 and surgery was required. CONCLUSIONS: Although RAN was the safest among the 3 agents, @entity7 and IVTA reduced @entity3 more than RAN, while significant improvement was achieved in BCVA in all groups. All 3 agents can be effectively used in the treatment of @entity4 due to BRVO.

title: Early results of @entity2 implant, ranibizumab, and triamcinolone in XXXX due to branch @entity5 .

answer: @entity4


abstract: PURPOSE: To compare the short-term results of the efficacy and safety of @entity2 intravitreal implant (DEX), ranibizumab (RAN), and intravitreal @entity6 (IVTA) in @entity4 secondary to branch @entity5 (BRVO). METHODS: One eye each of 32 @entity0 who were treated with intravitreal injections for @entity4 secondary to BRVO was studied. This retrospective study included 3 groups. The @entity0 received DEX in group 1 (n = 11), RAN in group 2 (n = 11), and IVTA in group 3 (n = 10). Data were collected before and after the injections at the first and third months. Best-corrected visual acuity (BCVA), @entity3 ( @entity3 ), and intraocular pressure (IOP) were analyzed statistically. RESULTS: The median duration of the follow-up was 3.0 months in overall groups. The BCVA increased significantly in all groups (p = 0.018, p = 0.034, p = 0.014, respectively). The @entity3 increased significantly in groups 1 and 3 (p = 0.02, plt;0.001, respectively), but not in group 2 (p = 0.14). The IOP increased significantly in groups 1 and 3 (p = 0.05, plt;0.001, respectively). Antiglaucomatous treatment was required only in group 3. @entity1 developed in 2 @entity0 (20%) in group 3 and surgery was required. CONCLUSIONS: Although RAN was the safest among the 3 agents, @entity7 and IVTA reduced @entity3 more than RAN, while significant improvement was achieved in BCVA in all groups. All 3 agents can be effectively used in the treatment of @entity4 due to BRVO.

title: Early results of @entity2 implant, ranibizumab, and triamcinolone in @entity4 due to branch XXXX .

answer: @entity5


abstract: To explore the potential of @entity1 -specific DNA as a biomarker for @entity2 ( @entity2 ), we queried DNA from saliva or plasma of 93 @entity2 @entity0 . We searched for somatic mutations or @entity3 genes, collectively referred to as @entity1 DNA. When both plasma and saliva were tested, @entity1 DNA was detected in 96% of 47 @entity0 . The fractions of @entity0 with detectable @entity1 DNA in early- and late-stage disease were 100% (n = 10) and 95% (n = 37), respectively. When segregated by site, @entity1 DNA was detected in 100% (n = 15), 91% (n = 22), 100% (n = 7), and 100% (n = 3) of @entity0 with @entity1 of the oral cavity, oropharynx, larynx, and hypopharynx, respectively. In saliva, @entity1 DNA was found in 100% of @entity0 with @entity4 and in 47 to 70% of @entity0 with @entity1 of the other sites. In plasma, @entity1 DNA was found in 80% of @entity0 with @entity4 , and in 86 to 100% of @entity0 with @entity1 of the other sites. Thus, saliva is preferentially enriched for @entity1 DNA from the oral cavity, whereas plasma is preferentially enriched for @entity1 DNA from the other sites. Tumor DNA in saliva was found postsurgically in three @entity0 before clinical diagnosis of recurrence, but in none of the five @entity0 without recurrence. Tumor DNA in the saliva and plasma appears to be a potentially valuable biomarker for detection of @entity2 .

title: Detection of somatic mutations and HPV in the saliva and plasma of @entity0 with XXXX .

answer: @entity2


abstract: To explore the potential of @entity1 -specific DNA as a biomarker for @entity2 ( @entity2 ), we queried DNA from saliva or plasma of 93 @entity2 @entity0 . We searched for somatic mutations or @entity3 genes, collectively referred to as @entity1 DNA. When both plasma and saliva were tested, @entity1 DNA was detected in 96% of 47 @entity0 . The fractions of @entity0 with detectable @entity1 DNA in early- and late-stage disease were 100% (n = 10) and 95% (n = 37), respectively. When segregated by site, @entity1 DNA was detected in 100% (n = 15), 91% (n = 22), 100% (n = 7), and 100% (n = 3) of @entity0 with @entity1 of the oral cavity, oropharynx, larynx, and hypopharynx, respectively. In saliva, @entity1 DNA was found in 100% of @entity0 with @entity4 and in 47 to 70% of @entity0 with @entity1 of the other sites. In plasma, @entity1 DNA was found in 80% of @entity0 with @entity4 , and in 86 to 100% of @entity0 with @entity1 of the other sites. Thus, saliva is preferentially enriched for @entity1 DNA from the oral cavity, whereas plasma is preferentially enriched for @entity1 DNA from the other sites. Tumor DNA in saliva was found postsurgically in three @entity0 before clinical diagnosis of recurrence, but in none of the five @entity0 without recurrence. Tumor DNA in the saliva and plasma appears to be a potentially valuable biomarker for detection of @entity2 .

title: Detection of somatic mutations and HPV in the saliva and plasma of XXXX with @entity2 .

answer: @entity0


abstract: UNASSIGNED: The optimal combination and sequence of radiotherapy (RT) and @entity5 ( @entity5 ) for extranodal nasal-type natural killer/ @entity2 (NKTCL) are not well-defined. The aim of this study was to create a risk-adapted therapeutic strategy for early-stage NKTCL. A total of 1273 early-stage @entity0 from 10 institutions were reviewed. @entity0 received @entity5 alone (n = 170), RT alone (n = 253), RT followed by @entity5 (n = 209), or @entity5 followed by RT (n = 641). A comprehensive comparative study was performed using multivariable and propensity score-matched analyses. Early-stage NKTCL was classified as low risk or high risk based on 5 independent prognostic factors (stage, age, performance status, @entity3 dehydrogenase, primary @entity1 invasion). RT alone and RT with or without @entity5 were more effective than @entity5 alone (5-year @entity4 [ @entity4 ], 69.6% and 67.7% vs 33.9%, P < .001). For low-risk @entity0 , RT alone achieved a favorable @entity4 (88.8%); incorporation of induction or consolidation @entity5 did not provide additional benefit (86.9% and 86.3%). For high-risk @entity0 , RT followed by @entity5 resulted in superior @entity4 (72.2%) compared with induction @entity5 and RT (58.3%, P = .004) or RT alone (59.6%, P = .017). After adjustment, similar significant differences in @entity4 were still observed between treatment groups. New @entity5 regimens provided limited benefit in early-stage NKTCL. Risk-adapted therapy involving RT alone for low-risk @entity0 and RT consolidated by @entity5 for high-risk @entity0 is a viable, effective strategy for early-stage NKTCL.

title: Risk-adapted therapy for early-stage extranodal nasal-type NK/ XXXX : analysis from a multicenter study.

answer: @entity2


abstract: BACKGROUND: Accumulating evidence indicates that circulating pericyte progenitor cells (CPPCs) may be angiogenic biomarkers in @entity0 and @entity1 . Their validity as biomarkers depends on the accuracy of techniques used for enumeration. In this report, absolute CPPC counts were performed by 2 single-platform technologies. The reliability of the 2 methods, including retest reliability and intraobserver and interobserver variability, was assessed according to the intraclass correlation coefficient (ICC). The linear correlation and agreement among both methods were assessed, and the stability of CPPC numbers in blood samples was analyzed. METHODS: The blood samples were obtained from ICR @entity2 . The samples were processed through a no-lyse, 1-wash procedure, and Syto16+ @entity6 - @entity4 - @entity5 + CPPCs were analyzed by exclusion of dead cells and by fluorescence-minus-one control. CPPCs were enumerated by 2 methods: bead-based 123count eBeads count (eBioscience) and direct volume-based Accuri C6 Flow Cytometer count ( @entity3 ). The cells were measured immediately and after storage of blood samples for 24 and 48 hours. RESULTS: There were excellent retest correlations and intraobserver and interobserver agreement in both methods. The 2 methods showed a high linear correlation (R2 = 0.923) and with a high level of agreement (0.986). It was demonstrated that CPPCs are unstable in blood samples. CONCLUSIONS: In this study, 2 reproducible protocols for CPPC quantification were established. These protocols should facilitate future studies to further define the role of CPPCs as cellular biomarkers.

title: Absolute circulating pericyte progenitor cell counts in XXXX by flow cytometry: comparison of 2 single-platform technologies.

answer: @entity2


abstract: OBJECTIVE: To investigate interrelations between @entity6 ( @entity6 ) and @entity4 ( @entity4 ) serum levels and common carotid arteries (CCA) remodeling in @entity2 @entity0 with @entity1 . DESIGN AND METHOD: 80 @entity2 @entity0 (51 obese) have been observed. An ultrasound examination of CCA with estimation of its geometrical type was performed (cut-off value for vascular wall @entity3 was vascular segment mass >0,275g/cm, concentric remodeling was diagnosed with relative wall thickness of CCA >0,2). @entity6 and @entity4 serum levels were estimated using ELISA. RESULTS: @entity6 and @entity4 levels were higher in @entity2 @entity0 (p<0,001), independently of BMI. Cluster analysis was made to reveal both cytokines' levels impact on CCA geometry. @entity6 >73pg/ml, @entity4 >25pg/ml was associated with 80,0% prevalence of normal CCA geometry and 20,0% of its @entity3 . @entity4 >20pg/ml with @entity6 <71pg/ml was characterized by 80,0% prevalence of normal geometry, 10,0% of non- @entity2 concentric remodeling of CCA, 5,0% of concnetric and 5,0% of @entity3 . @entity6 >71pg/ml with @entity4 <25pg/ml was associated with decrease of normal CCA geometry prevalence to 50,0% with increase of @entity3 rate to 41,7%; other 8,3% @entity0 had @entity5 . @entity6 <71 pg/ml, @entity4 <20pg/ml (p>0,05 vs control group) had 57,9% of normal geometry, 15,8% of concentric remodeling, 15,8% of concnetric @entity3 and 10,5% of @entity5 . CONCLUSIONS: @entity6 and @entity4 serum levels were elevated in @entity2 @entity0 independently of presence of @entity1 . A pronounced isolated increase in @entity6 level was associated with abrupt increase of CCA @entity3 prevalence, especially its concentric variant. Accompanying increase in @entity4 level reduced this effect.

title: 9A.08: INTERLEUKINS 33 AND XXXX SERUM LEVELS ARE CONNECTED TO COMMON CAROTID ARTERIES REMODELING IN HYPERTENSIVE @entity0 WITH OBESITY.

answer: @entity4


abstract: OBJECTIVE: To investigate interrelations between @entity6 ( @entity6 ) and @entity4 ( @entity4 ) serum levels and common carotid arteries (CCA) remodeling in @entity2 @entity0 with @entity1 . DESIGN AND METHOD: 80 @entity2 @entity0 (51 obese) have been observed. An ultrasound examination of CCA with estimation of its geometrical type was performed (cut-off value for vascular wall @entity3 was vascular segment mass >0,275g/cm, concentric remodeling was diagnosed with relative wall thickness of CCA >0,2). @entity6 and @entity4 serum levels were estimated using ELISA. RESULTS: @entity6 and @entity4 levels were higher in @entity2 @entity0 (p<0,001), independently of BMI. Cluster analysis was made to reveal both cytokines' levels impact on CCA geometry. @entity6 >73pg/ml, @entity4 >25pg/ml was associated with 80,0% prevalence of normal CCA geometry and 20,0% of its @entity3 . @entity4 >20pg/ml with @entity6 <71pg/ml was characterized by 80,0% prevalence of normal geometry, 10,0% of non- @entity2 concentric remodeling of CCA, 5,0% of concnetric and 5,0% of @entity3 . @entity6 >71pg/ml with @entity4 <25pg/ml was associated with decrease of normal CCA geometry prevalence to 50,0% with increase of @entity3 rate to 41,7%; other 8,3% @entity0 had @entity5 . @entity6 <71 pg/ml, @entity4 <20pg/ml (p>0,05 vs control group) had 57,9% of normal geometry, 15,8% of concentric remodeling, 15,8% of concnetric @entity3 and 10,5% of @entity5 . CONCLUSIONS: @entity6 and @entity4 serum levels were elevated in @entity2 @entity0 independently of presence of @entity1 . A pronounced isolated increase in @entity6 level was associated with abrupt increase of CCA @entity3 prevalence, especially its concentric variant. Accompanying increase in @entity4 level reduced this effect.

title: 9A.08: INTERLEUKINS 33 AND @entity4 SERUM LEVELS ARE CONNECTED TO COMMON CAROTID ARTERIES REMODELING IN HYPERTENSIVE XXXX WITH OBESITY.

answer: @entity0


abstract: OBJECTIVE: Renal 11 beta @entity10 dehydrogenase @entity4 2 (11BHSD2) is a key molecular player in the renin- angiotensin- @entity8 system (RAAS). We hypothesize that decreased renal 11BHSD2 activity, as measured by increased urinary free @entity5 to @entity6 (UFF/UFE) ratio using gas chromatography-mass spectrometry (GCMS), may be an important biomarker in identifying @entity1 @entity0 with increased left ventricular mass. DESIGN AND METHOD: We studied insulin-naive male @entity0 with @entity4 2 @entity1 and stage 1 @entity3 (blood pressure of 140-160/90-100 mmHg) in this study. 24-hour urine was collected and UFF/UFE ratio was determined using GCMS. All @entity0 underwent 2D-echocardiogram (2DE) for measurement of left ventricular mass index (LVMI). RESULTS: A total of 43 @entity1 male @entity0 with @entity3 were evaluated in this study. As per current @entity3 guidelines, all subjects were already taking either an @entity9 converting enzyme inhibitor (ACE) or angiotensin receptor blocker (ARB) for their @entity3 control. The mean 24 hour UFF/UFE ratio was 0.77+/- 0.05 (interquartile range 0.52 to 1.00), with higher UFF/UFE ratios reflecting lower renal 11BHSD2 activity. Higher UFF/UFE ratio correlated with higher LVMI (r=0.46, p=0.003). Among the subjects in the highest quartile (UFF/UFE ratio > 1.00), the left ventricular mass index was significantly higher (113.8g/m2 vs 89.1g/m2, p=0.03; difference between means 23.7+/- 9.8g/m2) when compared to the rest of the cohort. This association was independent of age, blood pressure, duration of @entity1 , medications, glycated hemoglobin (HBA1C), body mass index (BMI), ethnicity or serum @entity7 . CONCLUSIONS: In diabetics with stage 1 @entity3 , a 24 hour urine free @entity5 to @entity6 ratio >1.00 as measured by gas chromatography-mass spectrometry, independently identifies @entity0 with a significantly higher left ventricular mass, a subset of @entity0 known to be at a higher risk of developing @entity2 .

title: 4B.10: 24 HOUR URINE FREE @entity5 TO XXXX RATIO IS A NOVEL BIOMARKER FOR INCREASED LEFT VENTRICULAR MASS IN DIABETIC HYPERTENSIVES.

answer: @entity6


abstract: OBJECTIVE: Renal 11 beta @entity10 dehydrogenase @entity4 2 (11BHSD2) is a key molecular player in the renin- angiotensin- @entity8 system (RAAS). We hypothesize that decreased renal 11BHSD2 activity, as measured by increased urinary free @entity5 to @entity6 (UFF/UFE) ratio using gas chromatography-mass spectrometry (GCMS), may be an important biomarker in identifying @entity1 @entity0 with increased left ventricular mass. DESIGN AND METHOD: We studied insulin-naive male @entity0 with @entity4 2 @entity1 and stage 1 @entity3 (blood pressure of 140-160/90-100 mmHg) in this study. 24-hour urine was collected and UFF/UFE ratio was determined using GCMS. All @entity0 underwent 2D-echocardiogram (2DE) for measurement of left ventricular mass index (LVMI). RESULTS: A total of 43 @entity1 male @entity0 with @entity3 were evaluated in this study. As per current @entity3 guidelines, all subjects were already taking either an @entity9 converting enzyme inhibitor (ACE) or angiotensin receptor blocker (ARB) for their @entity3 control. The mean 24 hour UFF/UFE ratio was 0.77+/- 0.05 (interquartile range 0.52 to 1.00), with higher UFF/UFE ratios reflecting lower renal 11BHSD2 activity. Higher UFF/UFE ratio correlated with higher LVMI (r=0.46, p=0.003). Among the subjects in the highest quartile (UFF/UFE ratio > 1.00), the left ventricular mass index was significantly higher (113.8g/m2 vs 89.1g/m2, p=0.03; difference between means 23.7+/- 9.8g/m2) when compared to the rest of the cohort. This association was independent of age, blood pressure, duration of @entity1 , medications, glycated hemoglobin (HBA1C), body mass index (BMI), ethnicity or serum @entity7 . CONCLUSIONS: In diabetics with stage 1 @entity3 , a 24 hour urine free @entity5 to @entity6 ratio >1.00 as measured by gas chromatography-mass spectrometry, independently identifies @entity0 with a significantly higher left ventricular mass, a subset of @entity0 known to be at a higher risk of developing @entity2 .

title: 4B.10: 24 HOUR URINE FREE XXXX TO @entity6 RATIO IS A NOVEL BIOMARKER FOR INCREASED LEFT VENTRICULAR MASS IN DIABETIC HYPERTENSIVES.

answer: @entity5


abstract: OBJECTIVE: Smoking and @entity2 are important risk factors in the development of @entity1 ( @entity1 ). Control rates of @entity2 are quite poor with only <50% of @entity0 achieving target blood pressure (BP) after antihypertensive monotherapy. Smokers may have a blunted response to antihypertensive drugs but this has not been properly investigated. Therefore we studied the interaction between smoking status and BP response in never-treated @entity2 @entity0 . DESIGN AND METHOD: We studied 305 untreated @entity2 subjects (mean age 51  1, mean  SEM, F=124) classified according to their smoking status; non- smoker (n=134), smoker (n=64) and ex- smoker (n=104). Haemodynamic measurements including systolic and diastolic BP and heart rate (HR) were measured before and 1 month after monotherapy with commonly used antihypertensive agents;Data were analyzed using with JMP version 7.1 (SAS) for Windows. Results were expressed as mean  SEM, with p<0.05 considered significant. RESULTS: There was a significant relationship between smoking status and fall in BP; smokers and ex- smokers showed lower reduction than non- smokers for systolic BP (4  1.7 vs. 13.6  1 vs. 17.6  1) and diastolic BP (6.5  1.0 vs. 8.7  0.8 vs. 10  0.7, p<0.01) respectively. In a stepwise regression analysis, baseline systolic BP, smoking status and female gender were the only significant predictors of fall in systolic BP (R2=0.19, p<0.0001) with smokers exhibiting 2mm Hg less fall than smokers and ex-smokers. For reduction in diastolic BP, baseline diastolic BP and smoking status were the only significant predictors R2=0.19, p<0.0001) with smokers showing 2 mmHg less reduction in diastolic BP compared with non- smokers. CONCLUSIONS: Smoking is not only an important @entity1 factor in @entity2 @entity0 but also reduces the response to anti- @entity2 treatment, independent of age, gender and body mass index. Therefore, smoking cessation can achieve not only reduced @entity1 but may also improve BP control in @entity2 @entity0 .

title: 7B.07: CIGARETTE SMOKING REDUCES BLOOD PRESSURE RESPONSE TO ANTIHYPERTENSIVE TREATMENT IN NEWLY DIAGNOSED HYPERTENSIVE XXXX .

answer: @entity0


abstract: OBJECTIVE: The aim of our study was to investigate characteristics of late-onset @entity4 after 65 years compared to younger ones. METHOD: @entity0 with @entity4 revealed after 65 years were investigated in four French hospitals between 1985 and 2013. @entity0 with 4 ACR criteria or more were included. Clinical and biological characteristics, prognosis, treatment, comorbidities were described retrospectively and compared to the cohort of 1000 @entity4 @entity0 of Cervera et al. RESULTS: Eighteen @entity0 were included (14 @entity0 and 4 @entity0 ). The most frequent features were @entity2 (13/18), skin involvement (9/18). @entity5 and @entity3 were more frequently found in elderly @entity4 (p<0.05). During evolution, only cutaneous involvement were less frequent than in young subjects (p <0.05). @entity1 were often used (16/18), but iatrogenic complications were frequent (10/16). CONCLUSION: Diagnosis is difficult because of non-specific clinical features. Treatment needed a rigourous follow-up because of iatrogenic complications.

title: Late-onset XXXX in the elderly after 65 years: retrospective study of 18 cases.

answer: @entity4


abstract: UNASSIGNED: @entity1 kidney allocation protocols may influence timing of transplantation and graft quality for pediatric recipients. This study aimed to evaluate the effects of these protocols, including pediatric priority, on waiting time on dialysis, transplant type, donor age, and HLA matching according to state of transplant in Australia. De-identified information on @entity0 <15  yr of age who commenced RRT in NSW, Qld, and Victoria from 2002 to 2011 was retrieved from the ANZDATA. Transplant type, donor age, and HLA mismatching were compared between states, with competing risk regression used to examine the time to transplant. There were significant differences in waiting time to @entity1 transplantation between the three states. @entity0 in NSW and Qld waited a median of 14 and 11  months vs. 21  months in Victoria. The ratio of LD to @entity1 transplants was lower in NSW and Qld. Differences correlated with @entity1 pediatric priority in NSW and Qld. DDs in NSW were older than in the other states. HLA matching did not differ. @entity1 kidney allocation protocols with pediatric priority in Australian states were associated with shorter waiting times and increased @entity1 proportion.

title: Australian deceased donor kidney allocation protocols: Transplant waiting and graft quality for XXXX and adolescents.

answer: @entity0


abstract: Primary @entity6 is rare. Here we report an unusual case of @entity6 containing combined hepatocellular @entity4 . A mass in the right liver lobe of a 45-year-old @entity0 was accidentally discovered by ultrasonic inspection and computed tomography (CT) scan. Surgical resection was performed following a diagnosis of primary @entity1 . @entity11 and @entity10 were present, and diagnosis of @entity6 was confirmed. The @entity11 element consisted of hepatocellular @entity3 and foci of @entity4 . The @entity10 element was composed of spindle cells and bizarre cells, as well as foci of @entity7 and @entity8 . @entity2 cells diffusely expressed both hepatocyte specific markers cytokeratin (CK) 8/18 and cholangiocyte specific markers @entity12 , and @entity5 cells were positive for @entity9 . Interestingly, both @entity11 and @entity10 cells expressed epithelial membrane antigen. CD117-positive ductular reactions and small undifferentiated cells were observed. A liver progenitor cell origin of the @entity6 was proposed.

title: Primary combined hepatocellular-cholangiocellular XXXX : An unusual case.

answer: @entity5


abstract: AIM: We retrospectively analyzed our Institution experience with these @entity0 . The endpoints of the analysis were overall survival (OS), disease-free survival (DFS), local control (LC), @entity1 ( @entity1 ); results were compared with the literature. BACKGROUND: @entity3 in adult @entity0 is a very rare disease; the 5 and 10-year overall survival rates range between 33-78% and 27-56%, respectively. The collection of more clinical data is strongly needed. MATERIALS AND METHODS: From September 1975 to October 2006, we treated 16 adult @entity0 (9 males and 7 females) with a histological diagnosis of @entity3 . @entity2 were scored according to RTOG @entity2 scale. Karnofski performance status (KPS) and neurological performance status (NPS) pre- and post-RT were reported. Median age was 27 years (range 18-53 years). All the @entity0 received cranio-spinal irradiation, two @entity0 were also given chemotherapy. Median follow-up period was 121.5 months. RESULTS: In January 2014, 10/16 @entity0 were alive without evidence of disease, 6/16 died with progressive disease (1 local and spinal, 3 spinal and 2 extraneural). Ten-year LC, OS, DFS, @entity1 were, respectively, 84%, 67%, 60% and 59%. Univariate analysis shows that gross total resection is associated with better survival. No acute or late G3-G4 @entity2 was observed. CONCLUSIONS: This experience and the analysis of the literature confirm the efficacy of postoperative RT but also the need of large datasets to better define prognostic factors and the possible role of the association of chemotherapy.

title: Radiotherapy for XXXX : Long term result from a single institution. A review of prognostic factors and why we do need a multi-institutional cooperative program.

answer: @entity3


abstract: BACKGROUND: Disease registry is a database that includes information about @entity0 suffering a special kind of disease. The aim of this study was to first identify and compare the National @entity1 Registry (NRDR) characteristics in some countries with Iran; and second, develop a provisional and NRDR for Iran. MATERIALS AND METHODS: Retrieval of data of the NRDR was performed by scholars responsible in related agencies, including the Ministry of Health and Medical Education, @entity1 charity, and data registries in the United States, United Kingdom, Malaysia, and Iran. This research was applied, and the study was descriptive-comparative. The study population consisted of the NRDR in selected countries in which data were collected by forms that were designed according to the study objectives. Sources of data were researchers, articles, books, journals, databases, websites, related documents, and @entity0 who are active in this regard, and related agencies, including the Ministry of Health and Medical Education, and @entity0 support charity. The researchers collected data for each country based on the study objectives and then put them in comparative tables. Data were analyzed by descriptive, comparative, and theoretical methods. RESULTS: Most of the renal transplant teams report their own results as a single center experiences. America and Britain have a preeminent national registry of @entity1 compared to other countries. CONCLUSION: Given that control, prevention, and treatment of @entity2 incur high expenses and the disease is one of leading mortality factors in Iran and across the world and since national registry system for @entity2 can provide better tools and strategies to manage and evaluate @entity0 ' characteristics as well as risk factors which eventually leads to making better decisions.

title: Developing a provisional and national XXXX registry for Iran.

answer: @entity1


abstract: Seventy-two @entity0 with HBsAg-positive chronic @entity1 were studied for serum antibody to delta antigen (anti- @entity3 ) by radioimmunoassay. Delta antigen (HDAg) in liver of the 72 @entity0 was also studied immunohistochemically using peroxidase-labeled anti- @entity3 . In one of the 72 @entity0 , high titers of anti- @entity3 and intrahepatic HDAg were detected. In this @entity0 , HDAg was localized mainly in nuclei and occasionally in the cytoplasm of hepatocytes. By immunoelectron microscopy, HDAg was observed diffusely in some hepatocytic nuclei, but their nucleoli, perichromatin and heterochromatin were devoid of HDAg. Occasionally, inclusion body-like ring-shaped or irregularly shaped aggregates of HDAg were observed in nuclei. At higher magnification, these aggregates consisted of an HDAg-positive amorphous substance and microtubular structures. In their vicinity, scattered HDAg-positive granules were also present. By conventional electron microscopy, similar inclusion bodies composed of a clustered amorphous substance and microtubular structures 10-20 nm in diameter, together with 20-30 nm irregular granules were observed in hepatocyte nuclei, but no core of Dane particles were found. These novel intranuclear structures were not observed in other @entity0 with chronic @entity2 . It is suggested that they may represent the characteristic ultrastructure associated with @entity4 .

title: Intranuclear inclusion bodies in liver of chronic XXXX with @entity4 .

answer: @entity2


abstract: Seventy-two @entity0 with HBsAg-positive chronic @entity1 were studied for serum antibody to delta antigen (anti- @entity3 ) by radioimmunoassay. Delta antigen (HDAg) in liver of the 72 @entity0 was also studied immunohistochemically using peroxidase-labeled anti- @entity3 . In one of the 72 @entity0 , high titers of anti- @entity3 and intrahepatic HDAg were detected. In this @entity0 , HDAg was localized mainly in nuclei and occasionally in the cytoplasm of hepatocytes. By immunoelectron microscopy, HDAg was observed diffusely in some hepatocytic nuclei, but their nucleoli, perichromatin and heterochromatin were devoid of HDAg. Occasionally, inclusion body-like ring-shaped or irregularly shaped aggregates of HDAg were observed in nuclei. At higher magnification, these aggregates consisted of an HDAg-positive amorphous substance and microtubular structures. In their vicinity, scattered HDAg-positive granules were also present. By conventional electron microscopy, similar inclusion bodies composed of a clustered amorphous substance and microtubular structures 10-20 nm in diameter, together with 20-30 nm irregular granules were observed in hepatocyte nuclei, but no core of Dane particles were found. These novel intranuclear structures were not observed in other @entity0 with chronic @entity2 . It is suggested that they may represent the characteristic ultrastructure associated with @entity4 .

title: Intranuclear inclusion bodies in liver of chronic @entity2 with XXXX .

answer: @entity4


abstract: UNASSIGNED: The combined effect of heat treatment and electro-activated solution (EAS) on the heat resistance of spores of Clostridium sporogenes and @entity4 was assessed under various heating and exposure time combinations. The acid and neutral EAS showed the highest inhibitory activity, indicating that these solutions may be considered as strong sporicidal disinfectants. These EAS were able to cause a reduction of >= 6 log of spores of C.  sporogenes at 60    C in only 1  min of exposition. For @entity4 spores, a reduction of 4.5 log was observed at 60    C in 1  min, while in 5  min, >= 7 log CFU/ml reduction was observed. Inoculated puree of @entity1 and @entity3 were used as a food matrix for the determination of the heat resistance of these spores during the treatments in glass capillaries. The inactivation kinetics of the spores was studied in an oil bath. Combined treatment by EAS and temperature demonstrated a significant decrease in the heat resistance of C. sporogenes. The D100  C in @entity1 puree with @entity2 solution was 66.86  min while with acid and neutral EAS it was reduced down to 3.97 and 2.19  min, respectively. The spore of @entity4 displayed higher heat resistance as confirmed by other similar studies. Its D130  C in @entity1 puree showed a decrease from 1.45  min in @entity2 solution down to 1.30 and 0.93  min for acid and neutral EAS, respectively. The differences between the spores of these species are attributable to their different sensitivities with respect to pH, Redox potential and @entity0 .

title: Study of the combined effect of electro-activated solutions and heat treatment on the destruction of spores of Clostridium sporogenes and XXXX in model solution and vegetable puree.

answer: @entity4


abstract: OBJECTIVE: Exploring the clinical features of aviatic @entity6 to provide references for medical evaluation, prevention and control measures in aircrew. METHOD: To analysis and summary 605 cases with 503 pilots of @entity6 in aircrew during 1966 to 2013. RESULT: (1) There were 605 cases of aviatic @entity6 , including 550 cases of @entity3 and 55 cases of specific diseases. The general @entity6 included 140 cases of anatomical abnormalities in nasal cavity type, 290 cases of @entity1 in nasal cavity, 73 cases of @entity4 type, 47 cases of cyst and @entity0 type, and the specific @entity6 were 55 cases of @entity2 ( @entity2 ). (2) The, constituent ratio of @entity2 , which was @entity5 @entity2 , was 95.55%. (3) The constituent ratio of cyst and @entity0 type in nasal cavity was easier causing to @entity2 than anatomical abnormalities, @entity1 , @entity4 in nasal cavity (P < 0.05). (4) The grounded constituent ratio of secondary @entity2 was higher than anatomical abnormalities, @entity1 , @entity4 , cyst and @entity0 disease in nasal cavity (P < 0.05). (5) The ways of hypobaric chamber tests were different for the kinds of aircrew. The qualified adjustment function of sinuses for barometric pressure was an essential condition for aircrew to continue flying. (6) The key point for the treatment of aviatic @entity6 was to remove pathological change in nasal cavity and @entity2 and restore @entity2 ostium patency. The key point for the medical evaluation was to restore normal @entity2 pressure balance function. CONCLUSION: The key point of medical evaluation about aviatic @entity6 is to assess the @entity2 pressure balance function in hypobaric chamber tests. Normative treatment and medical evaluation can effectively avoid flight accidents and improve the attendance rate for aircrew.

title: [The clinical research of aviatic XXXX with medical evaluation prevention and control intervention].

answer: @entity6


abstract: Approximately 4% of U.S. abortions occur in desired pregnancies, with many resulting from @entity4 . The majority of terminations occur in the second trimester; however in recent years first-trimester ultrasound measurement for nuchal translucency, calculation of risk based on maternal age, and biochemistry at 11-14 weeks gestation, have resulted in earlier prenatal diagnoses for @entity3 . First trimester ultrasound can also now lead to diagnoses of major structural abnormalities including anecephaly, ventral wall defects, and @entity5 . The American College of Medical Genetics released recommendations underscoring the crucial importance of ethical counseling and substantive communication with parents facing a prenatal diagnosis of @entity4 . Unfortunately, the inability of health care providers to understand and empathize with the ardent desire of some parents to refuse termination is likely to be a large factor in the common practice of professionals attempting to steer expectant parents toward termination. Perinatal hospice is family-centered, comprehensive, and integrative in nature. The care provided by perinatal hospice units is delivered by an interdisciplinary team of obstetricians, pediatricians, nurses, social workers and chaplains in 130 locations throughout the U.S. Support is offered from diagnosis until @entity2 and beyond with time for "bonding, loving, and losing." "Hospice care is an interactive, and at times intense, form of care. Rather than simply 'letting nature take its course,' this approach empowers the family to take control of some of the consequences of their unfortunate situation." A primary focus of perinatal hospice is on fear reduction. Parents facing the @entity2 of an @entity0 often fear isolation and abandonment in addition to worrying about their @entity0 experiencing @entity1 . Parents are assured that they will be cared for and supported throughout this entire chapter of their lives, as their babies are kept comfortable and free of @entity1 until @entity2 . The approach is realistic without shattering hope that the diagnosis was wrong or that a miracle will take place as there is recognition that hope keeps parents going. There is also recognition that building memories is essential to the grieving process and frequent use of ultrasound is designed to provide visualization experience. Perinatal hospice teams assist in the development of birth plans, address the type and location of the delivery as well as aftercare of the mother and @entity0 .

title: Diagnosis of XXXX and the Increased Maternal Psychological Toll Associated with Pregnancy Termination.

answer: @entity4


abstract: INTRODUCTION: @entity1 is one of the most serious complications of pregnancy and one of the major causes of maternal mortality. Thus its prediction is a matter for serious concern. OBJECTIVE: The purpose of the present study is to determine the value of mean platelet volume ( @entity2 ) measurement in the first and third trimesters of pregnancy for the prediction of @entity1 . METHOD: A prospective nested case-control study was performed on pregnant @entity0 who were at 9-12weeks of pregnancy. In the first trimester and again in 26-28weeks, @entity2 was calculated. All eligible @entity0 were then monitored to delivery and the @entity2 of @entity0 who were pre-eclamptic was compared with the @entity2 of normotensive @entity0 . RESULTS: Pre-eclamptic @entity0 were compared with 269 normotensive @entity0 . @entity2 at the first trimester of pre-eclamptic @entity0 was significantly higher than normotensive @entity0 (10.2  1.06fl VS 9.68  1.09fl, P=0.008). Also, @entity2 at the third trimester of pregnancy of pre-eclamptic @entity0 was more than normotensives (10.16  1.23fl VS 9.62  1.12fl, P=0.009). Area under the curve in receiver operating characteristics (ROC) curve was calculated as 0.64 for the predictive value of @entity2 at the first and third trimesters of pregnancy, which showed a low value of this test for predicting of @entity1 . CONCLUSION: @entity2 at the first and third trimesters of pregnancy are higher in @entity0 who eventually would be pre-eclamptic, but has low predictive value and is not a good predictor of @entity1 .

title: Evaluation of the value of the first and third trimester maternal mean platelet volume ( @entity2 ) for prediction of XXXX .

answer: @entity1


abstract: INTRODUCTION: @entity1 is one of the most serious complications of pregnancy and one of the major causes of maternal mortality. Thus its prediction is a matter for serious concern. OBJECTIVE: The purpose of the present study is to determine the value of mean platelet volume ( @entity2 ) measurement in the first and third trimesters of pregnancy for the prediction of @entity1 . METHOD: A prospective nested case-control study was performed on pregnant @entity0 who were at 9-12weeks of pregnancy. In the first trimester and again in 26-28weeks, @entity2 was calculated. All eligible @entity0 were then monitored to delivery and the @entity2 of @entity0 who were pre-eclamptic was compared with the @entity2 of normotensive @entity0 . RESULTS: Pre-eclamptic @entity0 were compared with 269 normotensive @entity0 . @entity2 at the first trimester of pre-eclamptic @entity0 was significantly higher than normotensive @entity0 (10.2  1.06fl VS 9.68  1.09fl, P=0.008). Also, @entity2 at the third trimester of pregnancy of pre-eclamptic @entity0 was more than normotensives (10.16  1.23fl VS 9.62  1.12fl, P=0.009). Area under the curve in receiver operating characteristics (ROC) curve was calculated as 0.64 for the predictive value of @entity2 at the first and third trimesters of pregnancy, which showed a low value of this test for predicting of @entity1 . CONCLUSION: @entity2 at the first and third trimesters of pregnancy are higher in @entity0 who eventually would be pre-eclamptic, but has low predictive value and is not a good predictor of @entity1 .

title: Evaluation of the value of the first and third trimester maternal mean platelet volume ( XXXX ) for prediction of @entity1 .

answer: @entity2


abstract: Enkephalins are short lived peptides which are rapidly cleaved by 2 membrane peptidases: an @entity1 and a carboxypeptidase. Enkephalin-like immuno-reactivity has been demonstrated in the smooth muscle and in the myenteric plexus of the @entity0 lower esophageal sphincter (LES). Opioid receptors have been found in the gastrointestinal tract and recently an enkephalin analog has been shown to inhibit LES relaxation and modify the peristaltic progression of the esophageal contractions. @entity2 is an @entity1 inhibitor which prevents, at least to some extent, the hydrolysis of endogenous enkephalins. Thus, the present work was designed to study the effect of @entity2 on esophageal motility. Ten healthy volunteers (mean age: 23 years) were studied. On 2 separate days, each subject received in random order @entity2 (2.5 mg/kg intravenously at a constant rate in 20 min) or placebo. Esophageal manometry was performed with a Dentsleeve. Wet swallows (5 ml) were performed at 1 min intervals during 80 min and results were pooled in 10 min periods. @entity2 inhibited significantly (p less than 0.02) LES relaxation 20 min after the beginning of the infusion and throughout the study. The maximal effect occurred 50 min after the beginning of @entity2 infusion and LES relaxation (m +/- SEM) was reduced from 92 +/- 2.6 to 79.5 +/- 2.9 p. 100 (p less than 0.01). Duration, amplitude, and velocity of esophageal contractions were not modified. @entity2 an @entity1 inhibitor, is able to reproduce the effect of IV exogenous enkephalins on LES relaxation in @entity0 . This result suggest that endogenous enkephalins might play a role in the normal control of the LES relaxation.

title: Effects of an XXXX inhibitor on esophageal motility in @entity0 .

answer: @entity1


abstract: Enkephalins are short lived peptides which are rapidly cleaved by 2 membrane peptidases: an @entity1 and a carboxypeptidase. Enkephalin-like immuno-reactivity has been demonstrated in the smooth muscle and in the myenteric plexus of the @entity0 lower esophageal sphincter (LES). Opioid receptors have been found in the gastrointestinal tract and recently an enkephalin analog has been shown to inhibit LES relaxation and modify the peristaltic progression of the esophageal contractions. @entity2 is an @entity1 inhibitor which prevents, at least to some extent, the hydrolysis of endogenous enkephalins. Thus, the present work was designed to study the effect of @entity2 on esophageal motility. Ten healthy volunteers (mean age: 23 years) were studied. On 2 separate days, each subject received in random order @entity2 (2.5 mg/kg intravenously at a constant rate in 20 min) or placebo. Esophageal manometry was performed with a Dentsleeve. Wet swallows (5 ml) were performed at 1 min intervals during 80 min and results were pooled in 10 min periods. @entity2 inhibited significantly (p less than 0.02) LES relaxation 20 min after the beginning of the infusion and throughout the study. The maximal effect occurred 50 min after the beginning of @entity2 infusion and LES relaxation (m +/- SEM) was reduced from 92 +/- 2.6 to 79.5 +/- 2.9 p. 100 (p less than 0.01). Duration, amplitude, and velocity of esophageal contractions were not modified. @entity2 an @entity1 inhibitor, is able to reproduce the effect of IV exogenous enkephalins on LES relaxation in @entity0 . This result suggest that endogenous enkephalins might play a role in the normal control of the LES relaxation.

title: Effects of an @entity1 inhibitor on esophageal motility in XXXX .

answer: @entity0


abstract: Serum antibodies cytotoxic to the @entity4 cell line RPMI 4788 were studied in 42 @entity0 with @entity2 , 61 @entity0 with @entity1 , 27 @entity0 with other inflammatory diseases (disease-controls) and 22 healthy controls. @entity3 of antibodies towards RPMI 4788 was studied by means of a @entity5 release assay using peripheral blood mononuclear leucocytes of healthy subjects as effector cells. Using a four hour antibody dependent cell mediated cytotoxicity assay sera from 29% of @entity2 patients contained antibodies cytotoxic for the target, while only 3% of the @entity1 @entity0 and 6% of the disease controls and non of the healthy controls were positive. When an 18 hour assay was applied, however, not only 40% of @entity2 @entity0 , but also 14% of @entity1 @entity0 and 21% of disease controls were found positive. The reactive antibody in the four hour assay was mainly of the IgG class, which points at a classical antibody dependent cell mediated cytotoxicity mechanism. In the 18 hour cytotoxic assay IgG and particularly IgM antibodies were found to be reactive. This suggests that in the latter case other cellular cytotoxic mechanism might be involved. There was a significant inverse correlation between the appearance of the @entity2 restricted IgG-anticolon epithelial cell antibodies (four hour assay) and the disease activity (p less than 0.01). Absorption studies showed that the reactive antigen is not specific for @entity2 colonic tissue, but is similarly found in @entity1 , and to a lower extent in normal bowel, liver and kidney. The reactive antigen, however, could not be detected in brain and lymphoblastoid cells.

title: XXXX specific cytotoxic IgG-autoantibodies against @entity4 cells.

answer: @entity2


abstract: Serum antibodies cytotoxic to the @entity4 cell line RPMI 4788 were studied in 42 @entity0 with @entity2 , 61 @entity0 with @entity1 , 27 @entity0 with other inflammatory diseases (disease-controls) and 22 healthy controls. @entity3 of antibodies towards RPMI 4788 was studied by means of a @entity5 release assay using peripheral blood mononuclear leucocytes of healthy subjects as effector cells. Using a four hour antibody dependent cell mediated cytotoxicity assay sera from 29% of @entity2 patients contained antibodies cytotoxic for the target, while only 3% of the @entity1 @entity0 and 6% of the disease controls and non of the healthy controls were positive. When an 18 hour assay was applied, however, not only 40% of @entity2 @entity0 , but also 14% of @entity1 @entity0 and 21% of disease controls were found positive. The reactive antibody in the four hour assay was mainly of the IgG class, which points at a classical antibody dependent cell mediated cytotoxicity mechanism. In the 18 hour cytotoxic assay IgG and particularly IgM antibodies were found to be reactive. This suggests that in the latter case other cellular cytotoxic mechanism might be involved. There was a significant inverse correlation between the appearance of the @entity2 restricted IgG-anticolon epithelial cell antibodies (four hour assay) and the disease activity (p less than 0.01). Absorption studies showed that the reactive antigen is not specific for @entity2 colonic tissue, but is similarly found in @entity1 , and to a lower extent in normal bowel, liver and kidney. The reactive antigen, however, could not be detected in brain and lymphoblastoid cells.

title: @entity2 specific cytotoxic IgG-autoantibodies against XXXX cells.

answer: @entity4


abstract: The University of Iowa Hospitals and Clinics is located in the center of the United States in Eastern Iowa, @entity5 ,000 hospital beds, and is the largest university owned teaching hospital in the country. Over 35,000 @entity0 are admitted each year. The infection control efforts began in 1969 and were broadened in 1976 with the establishment and implementation of the Program of Epidemiology directed by W.J. Hierholzer, Jr., M.D., hospital epidemiologist. Hospital-wide surveillance is routinely performed by three and a half full-time equivalent LPN practitioners who assess problems and evaluate data essential to realistic identification of nosocomial infection rates, implementation of controls and evaluation of control measures. @entity4 surveillance, utilizing modified CDC criteria, has been performed since July 1976. Ward rounds are made by staff, utilizing nursing care and medication Kardex's, microbiology, hematology and X-ray reports. Importantly, the surveillance system is being validated by concurrent prospective surveys to determine the sensitivity and specificity of reporting data. Outbreaks/epidemics of @entity2 , such as @entity1 , @entity3 of unknown species, and wounds, as well as burns from manufactured changes in cautery grounds, have been identified and controlled before they have become major epidemics. Surveillance has identified one epidemic per 10,000 @entity0 admitted.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Organization and operation of the XXXX -control program of the University of Iowa Hospitals and Clinics.

answer: @entity4


abstract: Demonstration of @entity6 in the absence of @entity5 should provide important confirmation of silent @entity1 in @entity0 with asymptomatic ST segment changes. For this purpose, a new portable scintillation probe (VEST) similar to a miniaturized nuclear stethoscope combined with a Holter ECG was evaluated. After standard equilibrium radionuclide angiocardiography with @entity7 labelled red blood cells, the VEST was positioned under gamma-camera control and data were recorded from 1-12 h in 61 unselected @entity0 . Ejection fraction (LVEF), relative changes in volumes, heart rate and ST segment changes were determined. Reproducibility of LVEF at rest (r = 0.91; variability 3.8 +/- 3%, N = 19) and during exercise (r = 0.98; variability 3.2 +/- 2%, N = 19) was good. In 15 asymptomatic exercise tests four different patterns of LVEF and ST segment responses were identified: (1) decrease in LVEF followed by significant ST @entity2 (five times); (2) ST @entity2 followed by decrease in LVEF (three times); (3) decrease in LVEF without significant ST changes (three times); and (4) ST @entity2 without significant LVEF change (four times). In this still small series, patterns (1) to (3) corresponded to @entity0 with documented @entity4 , which was not the case for pattern (4). For detection of silent ischaemia at rest, a decrease in LVEF of greater than 5% lasting for greater than 1 min was defined as @entity3 . Using this definition, four spontaneous episodes of silent @entity3 could be demonstrated in two of three CCU @entity0 with @entity8 during 160-680 min of data recordings without simultaneous ST changes.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Ambulatory scintigraphic assessment of transient changes in left ventricular function: a new method for detection of silent XXXX .

answer: @entity1


abstract: To test the effect of previous strenuous training on @entity0 (LA) formation and on changes of @entity0 threshold ( @entity1 ) values, a group of seven male athletes aged 26.3 +/- 9.2 years, height 184 +/- 6.2 cm, body weight 79.3 +/- 8.1 kg, percentage of body fat 8.8 +/- 3.7 and VO2 max 56.2 +/- 5.4 ml/kg were examined on a treadmill to the maximum in the morning after 2 days of rest, and after 2 consecutive days of strenuous training. The @entity2 ( @entity2 ) in the morning prior to the exercise test was assessed by means of a 5-grade score. The values of LA max, @entity1 , and @entity2 on day 1 were 11.06 +/- 2.4 mmol/l, 3.5 +/- 0.4 m/s, and 0.6 +/- 0.4, respectively. The corresponding values on day 2 were 8.8 +/- 1.7 mmol/l, 4.0 +/- 0.3 m/s, and 2.0 +/- 0.5, respectively. The values on day 3 were 8.6 +/- 1.1 mmol/l, 4.1 +/- 0.4 m/s, and 2.1 +/- 0.7, respectively. Statistically significant differences on the 1st day were found in LA max, @entity1 , and @entity2 compared with days 2 and 3. No significant differences were found between the values for the 2nd and 3rd days. @entity1 values for day 1 were significantly lower than those for days 2 and 3. A significantly higher level of @entity2 in the morning prior to the test procedure was observed on days 2 and 3 compared with day 1. The @entity1 and @entity2 values for days 2 and 3 showed no significant difference.(ABSTRACT TRUNCATED @entity1 250 WORDS)

title: Reproducibility of post-exercise XXXX and anaerobic threshold.

answer: @entity0


abstract: A @entity1 @entity4 model was used to study the effectiveness of magnetic resonance imaging (MRI) with @entity3 contrast enhancement in defining the histologic margins of @entity2 . The effectiveness of this technique was compared to conventional computed tomography (CT) using iodinated contrast enhancement. Cultured @entity1 @entity4 cells were injected into the left hemisphere of adult mongrel @entity1 . The @entity1 developed @entity2 and progressive clinical signs. Serial MRI with and without @entity5 was compared to serial CT with and without @entity6 obtained on the same days. After the final scans, animals were sacrificed; the brains were removed and processed for routine histopathologic study. All @entity0 were visualized with contrast-enhanced MRI which proved most sensitive. @entity5 caused bright enhancement of @entity0 in a distribution that consistently corresponded to areas of pathologically proved @entity0 infiltration. Gross and microscopic autopsy findings correlated better with MRI than with CT which tended to produce poorer resolution and underrepresent the size of viable @entity0 . @entity3 -enhanced MRI is more accurate than unenhanced MRI, unenhanced CT, or enhanced CT in defining the histologic margins of @entity0 .

title: XXXX imaging using a @entity1 glioma model.

answer: @entity2


abstract: A @entity1 @entity4 model was used to study the effectiveness of magnetic resonance imaging (MRI) with @entity3 contrast enhancement in defining the histologic margins of @entity2 . The effectiveness of this technique was compared to conventional computed tomography (CT) using iodinated contrast enhancement. Cultured @entity1 @entity4 cells were injected into the left hemisphere of adult mongrel @entity1 . The @entity1 developed @entity2 and progressive clinical signs. Serial MRI with and without @entity5 was compared to serial CT with and without @entity6 obtained on the same days. After the final scans, animals were sacrificed; the brains were removed and processed for routine histopathologic study. All @entity0 were visualized with contrast-enhanced MRI which proved most sensitive. @entity5 caused bright enhancement of @entity0 in a distribution that consistently corresponded to areas of pathologically proved @entity0 infiltration. Gross and microscopic autopsy findings correlated better with MRI than with CT which tended to produce poorer resolution and underrepresent the size of viable @entity0 . @entity3 -enhanced MRI is more accurate than unenhanced MRI, unenhanced CT, or enhanced CT in defining the histologic margins of @entity0 .

title: @entity2 imaging using a XXXX glioma model.

answer: @entity1


abstract: @entity7 is a chronic @entity2 caused by Actinomyces species which may involve only soft tissue or bone or the two together. @entity6 of maxilla is relatively rare when compared to mandible. These are normal commensals and become pathogens when they gain entry into tissue layers and bone where they establish and maintain an anaerobic environment with extensive @entity3 and @entity1 . This infection spreads contiguously, frequently ignoring tissue planes and surrounding tissues or organ. The portal of entry may be @entity2 , and so forth which may lead to involvement of adjacent structures as pharynx, larynx, tonsils, and paranasal sinuses and has the propensity to damage extensively. Diagnosis is often delayed and is usually based on histopathology as they are cultured in fewer cases. The chronic clinical course without regional @entity4 may be essential in diagnosis. The management of actinomycotic @entity6 is surgical debridement of necrotic tissue combined with antibiotics for 3-6 months. The primary @entity7 arising within the maxilla with contiguous involvement of paranasal sinus with formation of @entity9 is rare. Hence, we present a 50-year-old female @entity0 with @entity8 which presented as @entity9 with suppurative and @entity5 features.

title: Actinomycotic XXXX Presenting as @entity9 : A Rare Case Report.

answer: @entity6