abstract: The purpose of this study was to evaluate the incidence and characteristics of @entity0 with port-site @entity1 following robotic assisted surgery for gynecological @entity2 . @entity0 who underwent robotic assisted total laparoscopic hysterectomy and surgical staging at a single institution from November 2006 through November 2011 were retrospectively identified. Medical records were reviewed and the following information was extracted: diagnosis, histology, @entity2 extension, procedure, complications and post-surgical intervention. Port-site @entity1 were differentiated between isolated and not isolated. All @entity1 were confirmed with biopsy and treated with chemotherapy and radiotherapy as indicated. Four hundred forty-six @entity0 with @entity3 were identified who had undergone robotic assisted hysterectomy and staging. Eight @entity0 were converted to laparotomy and excluded from the study. Of 438 @entity0 , 384 @entity0 were diagnosed with early stages (stages 1 and 2), and 54 were diagnosed with advanced stages (stages 3 and 4). A total of 332 @entity0 underwent pelvic lymphadenectomy regardless of the @entity3 ; of those, 283 with early stage disease underwent pelvic lymphadenectomy, while 49 with advanced stage disease underwent pelvic lymphadenectomy. One hundred seventy-six @entity0 received adjuvant treatment after surgical staging. Four @entity0 were identified with port-site @entity1 (0.9  %), two @entity0 were reported as isolated @entity1 . The mean @entity0 age was 63 and mean BMI was 37  kg/m(2). The incidence of port-site @entity1 is low after robotic assisted surgery for treatment of @entity3 (0.9  %). There is no clear risk factor for development of port-site @entity1 or easily identifiable prevention.

title: Low incidence of port-site XXXX after robotic assisted surgery for @entity3 staging: descriptive analysis.

answer: @entity1


abstract: The purpose of this study was to evaluate the incidence and characteristics of @entity0 with port-site @entity1 following robotic assisted surgery for gynecological @entity2 . @entity0 who underwent robotic assisted total laparoscopic hysterectomy and surgical staging at a single institution from November 2006 through November 2011 were retrospectively identified. Medical records were reviewed and the following information was extracted: diagnosis, histology, @entity2 extension, procedure, complications and post-surgical intervention. Port-site @entity1 were differentiated between isolated and not isolated. All @entity1 were confirmed with biopsy and treated with chemotherapy and radiotherapy as indicated. Four hundred forty-six @entity0 with @entity3 were identified who had undergone robotic assisted hysterectomy and staging. Eight @entity0 were converted to laparotomy and excluded from the study. Of 438 @entity0 , 384 @entity0 were diagnosed with early stages (stages 1 and 2), and 54 were diagnosed with advanced stages (stages 3 and 4). A total of 332 @entity0 underwent pelvic lymphadenectomy regardless of the @entity3 ; of those, 283 with early stage disease underwent pelvic lymphadenectomy, while 49 with advanced stage disease underwent pelvic lymphadenectomy. One hundred seventy-six @entity0 received adjuvant treatment after surgical staging. Four @entity0 were identified with port-site @entity1 (0.9  %), two @entity0 were reported as isolated @entity1 . The mean @entity0 age was 63 and mean BMI was 37  kg/m(2). The incidence of port-site @entity1 is low after robotic assisted surgery for treatment of @entity3 (0.9  %). There is no clear risk factor for development of port-site @entity1 or easily identifiable prevention.

title: Low incidence of port-site @entity1 after robotic assisted surgery for XXXX staging: descriptive analysis.

answer: @entity3


abstract: UNASSIGNED: The @entity1 tick (Rhipicephalus microplus) affects @entity1 industries in tropical and subtropical countries because it is the vector of @entity3 and @entity4 which constitutes a threat to the health of @entity1 . During blooding feeding, ticks secrete saliva containing a complex of bioactive molecules into the injured site to evade host's defensive responses. Serine protease inhibitors (serpins) are important anti-haemostatic molecules present in tick saliva that are necessary for a successful blood feeding. Several serpin sequences have been reported in R. microplus but there is a gap of information about their functions during host-parasite interactions. In this study, the RmS-15 expressed in the @entity2 @entity5 was characterised using kinetic assays and in vitro analysis. The inhibitory enzymatic assays conducted showed that RmS-15 is a physiological inhibitor of thrombin with a stoichiometric inhibition (SI) of 1.5 and high inhibition affinity with ka=9.3  0.5*104M(-1)s(-1). RmS-15 delayed the clotting of plasma in a dose-dependent manner as determined in a recalcification time assay. Significant elevated ELISA titres were observed in tick resistant and susceptible @entity1 on day 28 after the @entity0 (p<0.001). This data suggests direct contact of RmS-15 with the immune system of the host at the tick-feeding site. The present study contributed to the understanding of the biological functions of R. microplus serpins during host-parasite interactions which contributes to the design of future innovative methods for tick control.

title: Effective inhibition of thrombin by Rhipicephalus microplus serpin-15 (RmS-15) obtained in the XXXX @entity5 .

answer: @entity2


abstract: UNASSIGNED: The @entity1 tick (Rhipicephalus microplus) affects @entity1 industries in tropical and subtropical countries because it is the vector of @entity3 and @entity4 which constitutes a threat to the health of @entity1 . During blooding feeding, ticks secrete saliva containing a complex of bioactive molecules into the injured site to evade host's defensive responses. Serine protease inhibitors (serpins) are important anti-haemostatic molecules present in tick saliva that are necessary for a successful blood feeding. Several serpin sequences have been reported in R. microplus but there is a gap of information about their functions during host-parasite interactions. In this study, the RmS-15 expressed in the @entity2 @entity5 was characterised using kinetic assays and in vitro analysis. The inhibitory enzymatic assays conducted showed that RmS-15 is a physiological inhibitor of thrombin with a stoichiometric inhibition (SI) of 1.5 and high inhibition affinity with ka=9.3  0.5*104M(-1)s(-1). RmS-15 delayed the clotting of plasma in a dose-dependent manner as determined in a recalcification time assay. Significant elevated ELISA titres were observed in tick resistant and susceptible @entity1 on day 28 after the @entity0 (p<0.001). This data suggests direct contact of RmS-15 with the immune system of the host at the tick-feeding site. The present study contributed to the understanding of the biological functions of R. microplus serpins during host-parasite interactions which contributes to the design of future innovative methods for tick control.

title: Effective inhibition of thrombin by Rhipicephalus microplus serpin-15 (RmS-15) obtained in the @entity2 XXXX .

answer: @entity5


abstract: OBJECTIVE: To present 57 cases of @entity2 in @entity0 , analyzing the clinical characteristics, treatment and outcome of these lesions. METHODS: The clinical histories of @entity0 diagnosed with @entity2 , seen between 1998 and 2008 at the Oral and Maxillofacial Surgery Unit of a reference @entity0 's Hospital (0-14 years) were reviewed. All @entity0 with clinical diagnosis of @entity2 were included. RESULTS: Fifty-seven @entity0 , 21 @entity0 and 36 @entity0 , with a mean age of 5.1 years were included in the study. Thirty-two cases were located on the left side of the floor of the mouth. The lesion diameter varied between 1 and 3 cm in 27 cases, 22 were less than 1 cm, and 8 were larger than 3 cm. Fifty-four cases were asymptomatic and 3 ranulas had @entity1 on swallowing. Twenty-two cases were resolved by opening with a tract dilator and 35 by marsupialization. Seven cases recurred at a mean of 12 months after treatment, three of these from the marsupialization group. CONCLUSION: The majority of the oral ranulas occurred in females, asymptomatic, on the left side of the floor of the mouth, with a mean size of 1 to 3 cm; all lesions were treated by surgery, of which 7 recurred.

title: XXXX : clinical follow-up study of 57 cases.

answer: @entity2


abstract: AIM: @entity5 ( @entity5 ) precedes the development of @entity2 . Detection of the lesion is essential to management. This paper describes a prospective study to detect and ablate anal @entity4 ( @entity4 ) using white light (WL) narrow band imaging (NBI) and NBI with @entity3 (NBIA). METHOD: Sixty @entity0 with abnormal anal cytology and risk factors for @entity6 , underwent examination of the anoderm with a high definition gastroscope and NBIA. Targeted biopsies were taken and the lesions ablated and characterized histopathologically. Visualisation of the anal transitional zone (ATZ) was facilitated by retroflexion and examination through a disposable anoscope. RESULTS: Targeted biopsies were taken from lesions in 58 @entity0 . No lesion was seen in two @entity0 . Histopathology showed @entity4 in 48 (80.0%) of 60 biopsies. One biopsy showed @entity1 . Biopsies in 9 (15%) of the 60 @entity0 showed normal mucosa. Lesions were seen in white light in 27 (45%) of the 60 cases, NBI in 39(65%) and NBIA in 57(95%) . There was no major morbidity. Sensitivity analysis showed that all methods were significantly different from each other. CONCLUSION: Anal @entity4 in the ATZ and anal canal can be identified by NBIAPatient selection influences findings. Limitations include small sample size and non-randomization. This article is protected by copyright. All rights reserved.

title: Detection of XXXX is enhanced by narrow band imaging and @entity3 (NBIA).

answer: @entity6


abstract: AIM: @entity5 ( @entity5 ) precedes the development of @entity2 . Detection of the lesion is essential to management. This paper describes a prospective study to detect and ablate anal @entity4 ( @entity4 ) using white light (WL) narrow band imaging (NBI) and NBI with @entity3 (NBIA). METHOD: Sixty @entity0 with abnormal anal cytology and risk factors for @entity6 , underwent examination of the anoderm with a high definition gastroscope and NBIA. Targeted biopsies were taken and the lesions ablated and characterized histopathologically. Visualisation of the anal transitional zone (ATZ) was facilitated by retroflexion and examination through a disposable anoscope. RESULTS: Targeted biopsies were taken from lesions in 58 @entity0 . No lesion was seen in two @entity0 . Histopathology showed @entity4 in 48 (80.0%) of 60 biopsies. One biopsy showed @entity1 . Biopsies in 9 (15%) of the 60 @entity0 showed normal mucosa. Lesions were seen in white light in 27 (45%) of the 60 cases, NBI in 39(65%) and NBIA in 57(95%) . There was no major morbidity. Sensitivity analysis showed that all methods were significantly different from each other. CONCLUSION: Anal @entity4 in the ATZ and anal canal can be identified by NBIAPatient selection influences findings. Limitations include small sample size and non-randomization. This article is protected by copyright. All rights reserved.

title: Detection of @entity6 is enhanced by narrow band imaging and XXXX (NBIA).

answer: @entity3


abstract: INTRODUCTION: Hysterectomy for @entity4 is increasingly performed by laparoscopic surgical technique. Same-day discharge is safe, cost-saving, and acceptable to @entity0 undergoing laparoscopic hysterectomy, but concerns about increased perioperative risks in @entity1 @entity0 limit the utilization of same-day discharge in this population. We evaluated the risk of perioperative complications in @entity1 @entity0 undergoing laparoscopic hysterectomy for @entity4 or @entity5 in our institution during a period of rapid increase in the utilization of same-day discharge. METHODS: Single-institution retrospective cohort including all @entity1 @entity0 (body mass index [calculated as weight (kg)/[height (m)]] 30) undergoing laparoscopic hysterectomy for @entity4 or @entity5 between 2011 and 2013. RESULTS: A total of 388 @entity0 were included. Those with class III @entity1 were younger than those with class I or II (58.4 compared with 63.0 years, P<.001) and less likely to have invasive @entity4 (80.9% compared with 88.7%, P=.04). Those with class III @entity1 were significantly more likely to undergo robot-assisted laparoscopy than those with class I or II @entity1 (57.5% compared with 18.6%, P<.001). The rate of same-day discharge increased significantly over the 3-year study period: for those with class I and II @entity1 from 18.6% to 65.5% and for those with class III @entity1 from 12.7% to 61.4% (P<.001). During this period there were no significant differences in frequency of @entity2 within 30 days of surgery, including readmission, unscheduled surgery, or @entity3 (P=.1 for all). CONCLUSION: Same-day discharge is safe and feasible for the majority of @entity1 @entity0 undergoing laparoscopic surgery for @entity4 and @entity5 .

title: Safety and Feasibility of Same-Day Discharge in Obese @entity0 Undergoing Laparoscopic Hysterectomy for XXXX and Malignancy [335].

answer: @entity5


abstract: INTRODUCTION: Hysterectomy for @entity4 is increasingly performed by laparoscopic surgical technique. Same-day discharge is safe, cost-saving, and acceptable to @entity0 undergoing laparoscopic hysterectomy, but concerns about increased perioperative risks in @entity1 @entity0 limit the utilization of same-day discharge in this population. We evaluated the risk of perioperative complications in @entity1 @entity0 undergoing laparoscopic hysterectomy for @entity4 or @entity5 in our institution during a period of rapid increase in the utilization of same-day discharge. METHODS: Single-institution retrospective cohort including all @entity1 @entity0 (body mass index [calculated as weight (kg)/[height (m)]] 30) undergoing laparoscopic hysterectomy for @entity4 or @entity5 between 2011 and 2013. RESULTS: A total of 388 @entity0 were included. Those with class III @entity1 were younger than those with class I or II (58.4 compared with 63.0 years, P<.001) and less likely to have invasive @entity4 (80.9% compared with 88.7%, P=.04). Those with class III @entity1 were significantly more likely to undergo robot-assisted laparoscopy than those with class I or II @entity1 (57.5% compared with 18.6%, P<.001). The rate of same-day discharge increased significantly over the 3-year study period: for those with class I and II @entity1 from 18.6% to 65.5% and for those with class III @entity1 from 12.7% to 61.4% (P<.001). During this period there were no significant differences in frequency of @entity2 within 30 days of surgery, including readmission, unscheduled surgery, or @entity3 (P=.1 for all). CONCLUSION: Same-day discharge is safe and feasible for the majority of @entity1 @entity0 undergoing laparoscopic surgery for @entity4 and @entity5 .

title: Safety and Feasibility of Same-Day Discharge in Obese XXXX Undergoing Laparoscopic Hysterectomy for @entity5 and Malignancy [335].

answer: @entity0


abstract: BACKGROUND: @entity5 rarely occur in naturally conceived pregnancies, one in 30,000. However, this rate drastically increases, one in 100, in the setting of assisted reproductive technology. Thus, the diagnosis and management of @entity5 is imperative in a @entity0 undergoing @entity2 ( @entity2 ). CASE: A 27-year-old primigravid Caucasian @entity0 at 8 weeks of gestation presents to the emergency department with heavy @entity4 . She underwent @entity2 with an uneventful transfer of two embryos approximately 8 weeks prior. The postoperative course was complicated by @entity1 with paracentesis. Four weeks posttransfer, the @entity0 had an episode of @entity4 with a closed cervix. Two additional @entity3 episodes resulting in hospitalization and blood transfusion occurred during the eighth and ninth weeks of gestation. On the fourth episode of @entity3 an ultrasonogram showed a fetus with a heart rate in the cervical canal along with an intrauterine pregnancy. After explanation of risks and benefits, the @entity0 chose to have a curettage and cautery of the cervical canal. Bleeding ceased, the cervical pregnancy was terminated, and the intrauterine pregnancy went on to a term delivery. CONCLUSION: In this @entity5 , treatment of the ectopic pregnancy was tailored to the site of implantation and successfully utilized invasive therapy to preserve the concomitant intrauterine pregnancy.

title: Rare Complication of Embryo Transfer: Cervical XXXX [354].

answer: @entity5


abstract: OBJECTIVE: Epistaxis is the most frequent @entity2 with a high treatment morbidity. This study assessed the long-term outcome after @entity3 treatment with regard to @entity0 comfort during the treatment, long-term complications and rate of recurrences. METHODS: A questionnaire cohort study was performed at the ENT department of the University Hospital Zurich. In April 2014, 363 @entity0 were contacted, who were treated between March 2007 and April 2008 for the reason of @entity3 using a written questionnaire to elucidate the @entity0 ' condition after the treatment. The type of treatment, subjective discomfort as well as degree of @entity1 , complications, permanent sequelae and recurrences were assessed. RESULTS: 109 questionnaires were analyzed (response rate of 36%). The overall same-sided recurrence rate after successful treatment during the 6.4-year follow-up was 22%. Discomfort was reported in 48% after cautery, 86% after packing and in 11% after surgery. Strong or very strong @entity1 was perceived in 8% after cautery, 26% after packing and in 0% after surgery alone. Complications consisted of nasal crusting in 15% after cautery and nasal breathing impairment in 24% after packing. Permanent harm was reported in 4% after cautery versus 20% after packing plus surgery. CONCLUSIONS: The data confirm the high rate of recurrences despite adequate treatment in the long-term analysis. The rate of post-treatment complications is considerably high with nasal crusting being the main inconvenience. It further shows that @entity0 keep a vivid memory of the treatment even many years later and that packing is extremely uncomfortable to @entity0 .

title: The high rate of long-term recurrences and sequelae after XXXX treatment.

answer: @entity3


abstract: BACKGROUND: Endoscopic submucosal dissection (ESD) has become one of the mainstays of treatment for early @entity4 (EGC). Radical surgery is also a classical treatment method for EGC. There have been no systematic clinical studies of the curative effects and adverse events associated with ESD vs. radical surgery for EGC. This study investigated the therapeutic efficacy and safety of ESD and radical surgery for EGC. METHODS: Twenty-nine @entity0 with EGC underwent ESD, and 59 underwent radical surgery at Weihai Municipal Hospital. The pathological characteristics, postoperative outcomes, hospital course, morbidity and mortality were retrospectively compared between the two groups. RESULTS: The oncological clearance was 93.1  % (27/29) in the ESD group. Postoperative delayed @entity5 occurred in two @entity0 . The hospital stay ranged from 10 to 23  days, and the average stay was 14.3        3.7  days. The @entity0 were followed-up for 1 to 5  years, with a mean follow-up of 26.9        8.5  months. Regular endoscopic examinations showed that the wound had healed with no @entity1 recurrence in all of the @entity0 . In the radical surgery group, the oncological clearance was 100  % (59/59). The hospital stay ranged from 11 to 55  days, and the average stay was 21.7        9.3  days. The @entity0 were followed-up for 1 to 3.7  years, with a mean follow-up of 22.3        9.4  months. Nine @entity0 developed complications, including acute @entity2 (1/59) and symptomatic residual @entity6 (3/59). These complications were improved by an additional operation, @entity3 and comprehensive therapy. CONCLUSIONS: ESD achieved similar efficacy and had many advantages compared with radical surgery for the treatment of EGC.

title: A comparison of endoscopic submucosal dissection (ESD) and radical surgery for early XXXX : a retrospective study.

answer: @entity4


abstract: BACKGROUND: The deficit subtype of @entity2 is hypothesized to constitute a pathophysiologically distinct subgroup of @entity2 @entity0 suffering from enduring, @entity3 and various @entity1 . Matrix metalloproteinases (MMPs) are extracellularly acting endopeptidases the substrates of which are matrix and adhesion molecules. Recently, @entity6 has been shown to be involved in various forms of synaptic plasticity, learning and memory consolidation. The primary aim of the present study was to evaluate associations between the functional @entity6 @entity7 gene polymorphism and the deficit and @entity1 subtypes of @entity2 . METHODS: The study was conducted between 2009 and 2012. Deficit @entity2 was diagnosed using the @entity4 . The sample consisted of 468 @entity0 , Caucasians, of Polish descent with @entity5 10 diagnosis of @entity2 : 189 [51% males] were included in a @entity1 subgroup, 279 @entity0 [53% males] were included in a deficit subgroup. The control group consisted of 532 subjects, Caucasians, of Polish descent [51% males]. @entity6 @entity7 gene polymorphism was genotyped using the fluorescence resonance energy transfer (FRET) method and the Light Cycler System 2.0. RESULTS: The frequencies of genotypes and alleles did not differ between the @entity2 @entity0 and control group. The deficit and @entity1 @entity0 did not differ in terms of the genotype and allele frequencies. No differences were found in genotype and allele frequencies between the deficit @entity0 and the controls and between the @entity1 @entity0 and the controls. CONCLUSION: We found no evidence for the association between the functional @entity6 @entity7 gene polymorphism and deficit/ @entity1 subtypes of @entity2 .

title: Functional polymorphism of XXXX ( @entity6 ) gene is not associated with @entity2 and with its deficit subtype.

answer: @entity6


abstract: BACKGROUND: The deficit subtype of @entity2 is hypothesized to constitute a pathophysiologically distinct subgroup of @entity2 @entity0 suffering from enduring, @entity3 and various @entity1 . Matrix metalloproteinases (MMPs) are extracellularly acting endopeptidases the substrates of which are matrix and adhesion molecules. Recently, @entity6 has been shown to be involved in various forms of synaptic plasticity, learning and memory consolidation. The primary aim of the present study was to evaluate associations between the functional @entity6 @entity7 gene polymorphism and the deficit and @entity1 subtypes of @entity2 . METHODS: The study was conducted between 2009 and 2012. Deficit @entity2 was diagnosed using the @entity4 . The sample consisted of 468 @entity0 , Caucasians, of Polish descent with @entity5 10 diagnosis of @entity2 : 189 [51% males] were included in a @entity1 subgroup, 279 @entity0 [53% males] were included in a deficit subgroup. The control group consisted of 532 subjects, Caucasians, of Polish descent [51% males]. @entity6 @entity7 gene polymorphism was genotyped using the fluorescence resonance energy transfer (FRET) method and the Light Cycler System 2.0. RESULTS: The frequencies of genotypes and alleles did not differ between the @entity2 @entity0 and control group. The deficit and @entity1 @entity0 did not differ in terms of the genotype and allele frequencies. No differences were found in genotype and allele frequencies between the deficit @entity0 and the controls and between the @entity1 @entity0 and the controls. CONCLUSION: We found no evidence for the association between the functional @entity6 @entity7 gene polymorphism and deficit/ @entity1 subtypes of @entity2 .

title: Functional polymorphism of @entity6 ( XXXX ) gene is not associated with @entity2 and with its deficit subtype.

answer: @entity6


abstract: BACKGROUND: The deficit subtype of @entity2 is hypothesized to constitute a pathophysiologically distinct subgroup of @entity2 @entity0 suffering from enduring, @entity3 and various @entity1 . Matrix metalloproteinases (MMPs) are extracellularly acting endopeptidases the substrates of which are matrix and adhesion molecules. Recently, @entity6 has been shown to be involved in various forms of synaptic plasticity, learning and memory consolidation. The primary aim of the present study was to evaluate associations between the functional @entity6 @entity7 gene polymorphism and the deficit and @entity1 subtypes of @entity2 . METHODS: The study was conducted between 2009 and 2012. Deficit @entity2 was diagnosed using the @entity4 . The sample consisted of 468 @entity0 , Caucasians, of Polish descent with @entity5 10 diagnosis of @entity2 : 189 [51% males] were included in a @entity1 subgroup, 279 @entity0 [53% males] were included in a deficit subgroup. The control group consisted of 532 subjects, Caucasians, of Polish descent [51% males]. @entity6 @entity7 gene polymorphism was genotyped using the fluorescence resonance energy transfer (FRET) method and the Light Cycler System 2.0. RESULTS: The frequencies of genotypes and alleles did not differ between the @entity2 @entity0 and control group. The deficit and @entity1 @entity0 did not differ in terms of the genotype and allele frequencies. No differences were found in genotype and allele frequencies between the deficit @entity0 and the controls and between the @entity1 @entity0 and the controls. CONCLUSION: We found no evidence for the association between the functional @entity6 @entity7 gene polymorphism and deficit/ @entity1 subtypes of @entity2 .

title: Functional polymorphism of @entity6 ( @entity6 ) gene is not associated with XXXX and with its deficit subtype.

answer: @entity2


abstract: UNASSIGNED: @entity4 ( @entity5 ) is a widely prescribed stimulant drug for the treatment of @entity2 ( @entity2 ) in @entity0 and adolescents. Its use in this age group raises concerns regarding the potential interference with ongoing neurodevelopmental processes. Particularly the hippocampus is a highly plastic brain region that continues to develop postnatally and is involved in cognition and emotional behavior, functions known to be affected by @entity5 . In this study, we assessed whether hippocampal structure and function were affected by chronic oral @entity5 treatment and whether its effects were different in adolescent or adult @entity1 . Using behavioral testing, resting-state functional MRI, post-mortem structural magnetic resonance imaging (MRI), and immunohistochemistry, we assessed @entity5 's effects on recognition memory, @entity3 -like behavior, topological features of functional connectivity networks, hippocampal shape and markers for hippocampal neurogenesis and proliferation. Object recognition memory was transiently impaired in adolescent treated @entity1 , while in animals treated during adulthood, increased @entity3 -like behavior was observed. Neurogenesis was increased in adolescent treated @entity1 , whereas cell proliferation was decreased following adult treatment. Adolescent treated @entity1 showed inward shape deformations adjacent to ventral parahippocampal regions known to be involved in recognition memory, whereas such deformations were not observed in adult treated animals. Irrespective of the age of treatment, @entity5 affected topological features of ventral hippocampal functional networks. Thus, chronic oral treatment with a therapeutically relevant dose of @entity5 preferentially affected the ventral part of the hippocampus and induced contrasting effects in adolescent and adult @entity1 . The differences in behavior were paralleled by opposite effects on adult neurogenesis and granule cell proliferation.

title: Effects of long-term XXXX treatment in adolescent and adult @entity1 on hippocampal shape, functional connectivity and adult neurogenesis.

answer: @entity4


abstract: UNASSIGNED: @entity4 ( @entity5 ) is a widely prescribed stimulant drug for the treatment of @entity2 ( @entity2 ) in @entity0 and adolescents. Its use in this age group raises concerns regarding the potential interference with ongoing neurodevelopmental processes. Particularly the hippocampus is a highly plastic brain region that continues to develop postnatally and is involved in cognition and emotional behavior, functions known to be affected by @entity5 . In this study, we assessed whether hippocampal structure and function were affected by chronic oral @entity5 treatment and whether its effects were different in adolescent or adult @entity1 . Using behavioral testing, resting-state functional MRI, post-mortem structural magnetic resonance imaging (MRI), and immunohistochemistry, we assessed @entity5 's effects on recognition memory, @entity3 -like behavior, topological features of functional connectivity networks, hippocampal shape and markers for hippocampal neurogenesis and proliferation. Object recognition memory was transiently impaired in adolescent treated @entity1 , while in animals treated during adulthood, increased @entity3 -like behavior was observed. Neurogenesis was increased in adolescent treated @entity1 , whereas cell proliferation was decreased following adult treatment. Adolescent treated @entity1 showed inward shape deformations adjacent to ventral parahippocampal regions known to be involved in recognition memory, whereas such deformations were not observed in adult treated animals. Irrespective of the age of treatment, @entity5 affected topological features of ventral hippocampal functional networks. Thus, chronic oral treatment with a therapeutically relevant dose of @entity5 preferentially affected the ventral part of the hippocampus and induced contrasting effects in adolescent and adult @entity1 . The differences in behavior were paralleled by opposite effects on adult neurogenesis and granule cell proliferation.

title: Effects of long-term @entity4 treatment in adolescent and adult XXXX on hippocampal shape, functional connectivity and adult neurogenesis.

answer: @entity1


abstract: BACKGROUND: @entity4 ( @entity4 )-associated @entity5 (IFALD) is the major cause of mortality in @entity4 . The link between intestinal microbiota and IFALD is unclear. METHODS: We compared intestinal microbiota of @entity0 with @entity4 (n = 23) with healthy controls (n = 58) using culture-independent phylogenetic microarray analysis. The microbiota was related to histological @entity3 , fecal markers of @entity1 , @entity7 and calprotectin, and disease characteristics. RESULTS: Overabundance of Lactobacilli, Proteobacteria, and Actinobacteria was observed in @entity4 , whereas bacteria related to Clostridium clusters III, IV, and XIVa along with overall diversity and richness were reduced. @entity0 were segregated into 3 subgroups based on dominating bacteria: Clostridium cluster XIVa, Proteobacteria, and bacteria related to @entity6 . In addition to @entity8 and @entity2 , Proteobacteria were associated with prolonged current @entity9 ( @entity9 ) as well as liver and @entity1 . Lactobacilli were related to advanced @entity8 and @entity2 mostly after weaning off @entity9 without associated @entity1 . In multivariate permutational analysis of variance, @entity8 , bowel length, @entity9 calories, and antibiotic treatment best explained the microbiota variation among @entity0 with @entity4 . CONCLUSIONS: Intestinal microbiota composition was associated with @entity8 in @entity4 and better predicted @entity8 than duration of @entity9 or length of the remaining intestine. Our results may be explained by a model in which @entity8 is initiated during @entity9 in response to proinflammatory lipopolysaccharides produced by Proteobacteria and progresses after weaning off @entity9 , as the @entity6 group Lactobacilli becomes dominant and affects lipid metabolism by altering @entity10 signaling.

title: Intestinal Microbiota Signatures Associated With XXXX in @entity4 .

answer: @entity8


abstract: BACKGROUND: @entity4 ( @entity4 )-associated @entity5 (IFALD) is the major cause of mortality in @entity4 . The link between intestinal microbiota and IFALD is unclear. METHODS: We compared intestinal microbiota of @entity0 with @entity4 (n = 23) with healthy controls (n = 58) using culture-independent phylogenetic microarray analysis. The microbiota was related to histological @entity3 , fecal markers of @entity1 , @entity7 and calprotectin, and disease characteristics. RESULTS: Overabundance of Lactobacilli, Proteobacteria, and Actinobacteria was observed in @entity4 , whereas bacteria related to Clostridium clusters III, IV, and XIVa along with overall diversity and richness were reduced. @entity0 were segregated into 3 subgroups based on dominating bacteria: Clostridium cluster XIVa, Proteobacteria, and bacteria related to @entity6 . In addition to @entity8 and @entity2 , Proteobacteria were associated with prolonged current @entity9 ( @entity9 ) as well as liver and @entity1 . Lactobacilli were related to advanced @entity8 and @entity2 mostly after weaning off @entity9 without associated @entity1 . In multivariate permutational analysis of variance, @entity8 , bowel length, @entity9 calories, and antibiotic treatment best explained the microbiota variation among @entity0 with @entity4 . CONCLUSIONS: Intestinal microbiota composition was associated with @entity8 in @entity4 and better predicted @entity8 than duration of @entity9 or length of the remaining intestine. Our results may be explained by a model in which @entity8 is initiated during @entity9 in response to proinflammatory lipopolysaccharides produced by Proteobacteria and progresses after weaning off @entity9 , as the @entity6 group Lactobacilli becomes dominant and affects lipid metabolism by altering @entity10 signaling.

title: Intestinal Microbiota Signatures Associated With @entity8 in XXXX .

answer: @entity4


abstract: BACKGROUND: There is increasing evidence that immune processes are important in the development of @entity4 . We investigated whether low density lipoprotein (LDL) adsorption therapy affected serum cytokine levels and the expression of adhesion molecules on peripheral blood mononuclear cells (lymphocytes and monocytes) in @entity0 with @entity5 ( @entity5 ). METHODS AND RESULTS: LDL adsorption therapy was repeated ten times over a period of three months in ten @entity5 @entity0 . The total serum @entity1 and LDL @entity1 levels were significantly reduced at the end of therapy. This was associated with a significant improvement in Fontaine's classification and ankle pressure index. We also measured serum levels of inflammatory cytokines ( @entity6 ( @entity6 ), @entity3 and tissue necrosis factor alpha ( @entity2 )) and expression of adhesion molecules (lymphocyte function-associated antigen 1 alpha ( @entity7 ), LFA-1 beta, @entity9 , very late antigen (VLA)-4, @entity10 and @entity8 ) on mononuclear cells in the same @entity0 and a group of healthy subjects. Serum levels of all inflammatory cytokines were markedly higher in @entity5 @entity0 compared with healthy subjects, but there was no significant difference in the level before and after LDL adsorption. VLA-4 expression on CD3+ cells, but not of other adhesion molecules, was markedly higher in @entity5 @entity0 compared with healthy subjects. LDL adsorption caused a significant reduction in @entity9 , VLA4 and @entity10 expression on CD3+ cells. Furthermore, VLA-4 and @entity10 expression on monocytes diminished significantly after LDL adsorption. CONCLUSIONS: Our results indicate that LDL adsorption-induced immunoregulation is mediated by an indirect stimulatory effect on the immune system. The results suggests that improved peripheral circulation produced by LDL adsorption may reflect improved immune dysfunctions of @entity4 in @entity5 @entity0 .

title: Removal of LDL from plasma by adsorption reduces adhesion molecules on mononuclear cells in XXXX with arteriosclerosis obliterans.

answer: @entity0


abstract: BACKGROUND: The late-onset pseudodendrites, delayed @entity4 , of herpes @entity3 are reported to be of mechanical or immune origin and to be worsened by antiviral therapy. OBJECTIVE: To study pseudodendrites to ascertain a viral presence in the lesions and their response to antiviral therapy. DESIGN: Prospective clinical study. SETTING: Outpatient and inpatient hospital-based corneal specialty referral practice; molecular virology laboratory. @entity0 : Six @entity0 , aged 33 to 89 years, four with delayed herpes @entity3 pseudodendrites and two with herpes @entity3 neurotrophic ulceration. One @entity0 was immunosuppressed. MAIN OUTCOME MEASURES: Findings from clinical evaluation; polymerase chain reaction assays of lesions and tear film of six @entity0 ; polymerase chain reaction and light and electron microscopy of the corneal button from one @entity0 ; and the clinical response of four @entity0 to various antiviral drugs. RESULTS: In contrast to reports in the current literature, delayed pseudodendrites may also be infectious, as they are positive for zoster DNA by polymerase chain reaction and appear responsive to certain antiviral therapy. The corneal button from an immunosuppressed @entity0 had mature and immature viral particles in the basal cells within 2 weeks of transplantation. CONCLUSIONS: To our knowledge, this is the first report of viral DNA in delayed @entity2 . Recurrent @entity1 may play a role in this form of @entity2 and warrant antiviral therapy.

title: XXXX . Polymerase chain reaction detection of viral DNA and a role for antiviral therapy.

answer: @entity2


abstract: OBJECTIVE: To evaluate the usefulness of various optical and surgical treatment modalities in the treatment of @entity0 who were symptom free in the primary position of gaze yet had symptomatic @entity1 in the reading position (down gaze at near). @entity0 AND METHODS: A retrospective chart review was conducted to identify all @entity0 with @entity5 I have treated who were symptom free in the primary position but had @entity1 in down gaze associated with vertically incomitant strabismus. Of 51 @entity0 identified, 32 were symptomatic in down gaze due to a @entity6 associated with a unilateral inferior rectus muscle underaction. Twenty-two of these @entity0 had previously undergone recession of the affected inferior rectus muscle for treatment of @entity2 ; four @entity0 , for correction of entrapment secondary to blow-out orbital fracture; and four @entity0 , for treatment of superior oblique muscle palsy. Two @entity0 had undergone prior surgery for superior oblique @entity4 . Eight @entity0 had horizontal @entity1 associated with an A pattern, and eight @entity0 had horizontal @entity1 associated with a V pattern. Three @entity0 had vertical and horizontal @entity1 after partial recovery from @entity3 . RESULTS: The treatment modalities were varied and individualized. Treatment consisted of optical management (20 @entity0 ), surgical management (21 @entity0 ), or a combination of both (10 @entity0 ). These treatment modalities resulted in comfortable single binocular vision for reading in 41 of the 51 @entity0 . Successful optical treatment consisted of Fresnel prisms (four @entity0 ), slab-off prisms (two @entity0 ), single-vision readers (seven @entity0 ), switch to nonprogressive bifocal lenses (three @entity0 ), and a high bifocal segment (16 @entity0 ). Successful surgical modalities included posterior fixation of the contralateral inferior rectus muscle (10 @entity0 ), surgery for A- or V- pattern strabismus (five @entity0 ), or bilateral inferior rectus muscle recession (six @entity0 ). CONCLUSION: @entity1 in the reading position frequently can be alleviated with a systematic approach that includes both optical and surgical modalities.

title: Management of XXXX limited to down gaze.

answer: @entity1


abstract: UNASSIGNED: Antimicrobial resistance in microbes poses a global and increasing threat to public health. The horizontal transfer of antimicrobial resistance genes was thought to be due largely to conjugative plasmids or transposons with only a minor part played by transduction through bacteriophages. However, whole genome sequencing has recently shown that the latter mechanism could be highly important in the exchange of antimicrobial resistance between microorganisms and environments. The transfer of antimicrobial resistance by phages could underlie the origin of resistant bacteria found in food. We show that @entity4 meat carries a number of phages capable of transferring antimicrobial resistance. Of 243 phages randomly isolated from @entity4 meat, about a quarter (24.7%) were able to transduce one or more of the five antimicrobial resistances tested into @entity1 ATCC 13706 (DSM 12242). Resistance to @entity6 was transduced most often, followed by that to @entity5 , with four phages transducing @entity2 resistance and three doing so for resistance to @entity3 . Phages able to transduce antimicrobial resistance were isolated from 44% of the samples of @entity4 we tested. A statistically significant (P=0.01) relationship between the presence of phages transducing @entity6 resistance and @entity1 isolates resistant to this antibiotic suggests that transduction may be an important mechanism for transferring @entity6 resistance to @entity1 . It appears that transduction of certain antimicrobial resistances e.g. @entity6 is not only widely distributed in @entity1 found on meat but could represent a major mechanism for resistance transfer. The result is of high importance for animal and @entity0 health.

title: Bacteriophages isolated from XXXX meat and the horizontal transfer of antimicrobial resistance genes.

answer: @entity4


abstract: Excessive exposure to polycyclic aromatic hydrocarbons (PAHs) often results in @entity1 , a disease with the @entity2 mortality in the United States. After entry into the lung, PAHs induce phase I metabolic enzymes such as cytochrome P450 (CYP) monooxygenases, i.e. CYP1A1/2 and 1B1, and phase II enzymes such as glutathione S-transferases, UDP glucuronyl transferases, NADPH quinone oxidoreductases (NQOs), aldo-keto reductases (AKRs), and epoxide hydrolases (EHs), via the @entity4 ( @entity4 )-dependent and independent pathways. @entity0 can also be exposed to PAHs through diet, via consumption of charcoal broiled foods. Metabolism of PAHs through the CYP1A1/1B1/EH pathway, CYP peroxidase pathway, and AKR pathway leads to the formation of the active carcinogens diol-epoxides, radical cations, and o-quinones. These reactive metabolites produce DNA adducts, resulting in DNA mutations, alteration of gene expression profiles, and tumorigenesis. Mutations in xenobiotic metabolic enzymes, as well as polymorphisms of @entity2 suppressor genes (e.g. @entity3 ) and/or genes involved in gene expression (e.g. X-ray repair cross-complementing proteins), are associated with @entity1 susceptibility in @entity0 populations from different ethnicities, gender, and age groups. Although various metabolic activation/inactivation pathways, @entity4 signaling, and genetic susceptibilities contribute to @entity1 , the precise points at which PAHs induce @entity2 initiation remain unknown. The goal of this review is to provide a current state-of-the-science of the mechanisms of @entity0 lung carcinogenesis mediated by PAHs, the experimental approaches used to study this complex class of compounds, and future directions for research of these compounds.

title: Polycyclic aromatic hydrocarbons: from metabolism to XXXX .

answer: @entity1


abstract: A prospective randomised study was undertaken in @entity0 with @entity2 ( @entity2 ), which compared @entity4 , 50 mg/m2, and @entity7 , 2 mg i.v. (intravenously) on day 1, with either @entity5 , 800 mg/m2 on day 1 ( @entity9 ) or @entity8 , 60 mg/m2 i.v. on day 1 and 120 mg/m2 orally on days 2-5 (AVE). Responding @entity0 were to receive six cycles of chemotherapy at 3 weekly intervals followed after 2 weeks by mediastinal irradiation. Response rates and @entity1 were evaluated by the chi square or Fisher's exact test and survival by the logrank test. 81 @entity0 were entered into the study, 38 of whom received @entity9 and 43 received AVE. In the @entity0 treated with @entity9 and AVE, the overall response rate was 61% (confidence limit (CL), 45-71%) and 74% (CL, 61-87%) respectively, the complete response rate was 32% (CL, 17-47%) and 51% (CL, 36-66%), respectively (P = 0.07) and the median survival was 12 and 14.5 months, respectively (P = 0.15). In the @entity0 treated with @entity9 and AVE, the incidence of grade 3 and 4 @entity6 was 29% (CL, 15-43%) and 9% (CL, 0-18%), respectively (P = 0.025). No @entity0 developed @entity4 @entity3 . These findings support the role of @entity8 in first line chemotherapy for @entity2 . AVE is among the more efficacious regimens for @entity2 and also has a relatively low @entity1 .

title: A prospective randomised study in limited disease small cell carcinoma-- XXXX and @entity7 plus either @entity5 or @entity8 .

answer: @entity4


abstract: A prospective randomised study was undertaken in @entity0 with @entity2 ( @entity2 ), which compared @entity4 , 50 mg/m2, and @entity7 , 2 mg i.v. (intravenously) on day 1, with either @entity5 , 800 mg/m2 on day 1 ( @entity9 ) or @entity8 , 60 mg/m2 i.v. on day 1 and 120 mg/m2 orally on days 2-5 (AVE). Responding @entity0 were to receive six cycles of chemotherapy at 3 weekly intervals followed after 2 weeks by mediastinal irradiation. Response rates and @entity1 were evaluated by the chi square or Fisher's exact test and survival by the logrank test. 81 @entity0 were entered into the study, 38 of whom received @entity9 and 43 received AVE. In the @entity0 treated with @entity9 and AVE, the overall response rate was 61% (confidence limit (CL), 45-71%) and 74% (CL, 61-87%) respectively, the complete response rate was 32% (CL, 17-47%) and 51% (CL, 36-66%), respectively (P = 0.07) and the median survival was 12 and 14.5 months, respectively (P = 0.15). In the @entity0 treated with @entity9 and AVE, the incidence of grade 3 and 4 @entity6 was 29% (CL, 15-43%) and 9% (CL, 0-18%), respectively (P = 0.025). No @entity0 developed @entity4 @entity3 . These findings support the role of @entity8 in first line chemotherapy for @entity2 . AVE is among the more efficacious regimens for @entity2 and also has a relatively low @entity1 .

title: A prospective randomised study in limited disease small cell carcinoma-- @entity4 and @entity7 plus either @entity5 or XXXX .

answer: @entity8


abstract: A prospective randomised study was undertaken in @entity0 with @entity2 ( @entity2 ), which compared @entity4 , 50 mg/m2, and @entity7 , 2 mg i.v. (intravenously) on day 1, with either @entity5 , 800 mg/m2 on day 1 ( @entity9 ) or @entity8 , 60 mg/m2 i.v. on day 1 and 120 mg/m2 orally on days 2-5 (AVE). Responding @entity0 were to receive six cycles of chemotherapy at 3 weekly intervals followed after 2 weeks by mediastinal irradiation. Response rates and @entity1 were evaluated by the chi square or Fisher's exact test and survival by the logrank test. 81 @entity0 were entered into the study, 38 of whom received @entity9 and 43 received AVE. In the @entity0 treated with @entity9 and AVE, the overall response rate was 61% (confidence limit (CL), 45-71%) and 74% (CL, 61-87%) respectively, the complete response rate was 32% (CL, 17-47%) and 51% (CL, 36-66%), respectively (P = 0.07) and the median survival was 12 and 14.5 months, respectively (P = 0.15). In the @entity0 treated with @entity9 and AVE, the incidence of grade 3 and 4 @entity6 was 29% (CL, 15-43%) and 9% (CL, 0-18%), respectively (P = 0.025). No @entity0 developed @entity4 @entity3 . These findings support the role of @entity8 in first line chemotherapy for @entity2 . AVE is among the more efficacious regimens for @entity2 and also has a relatively low @entity1 .

title: A prospective randomised study in limited disease small cell carcinoma-- @entity4 and XXXX plus either @entity5 or @entity8 .

answer: @entity7


abstract: A prospective randomised study was undertaken in @entity0 with @entity2 ( @entity2 ), which compared @entity4 , 50 mg/m2, and @entity7 , 2 mg i.v. (intravenously) on day 1, with either @entity5 , 800 mg/m2 on day 1 ( @entity9 ) or @entity8 , 60 mg/m2 i.v. on day 1 and 120 mg/m2 orally on days 2-5 (AVE). Responding @entity0 were to receive six cycles of chemotherapy at 3 weekly intervals followed after 2 weeks by mediastinal irradiation. Response rates and @entity1 were evaluated by the chi square or Fisher's exact test and survival by the logrank test. 81 @entity0 were entered into the study, 38 of whom received @entity9 and 43 received AVE. In the @entity0 treated with @entity9 and AVE, the overall response rate was 61% (confidence limit (CL), 45-71%) and 74% (CL, 61-87%) respectively, the complete response rate was 32% (CL, 17-47%) and 51% (CL, 36-66%), respectively (P = 0.07) and the median survival was 12 and 14.5 months, respectively (P = 0.15). In the @entity0 treated with @entity9 and AVE, the incidence of grade 3 and 4 @entity6 was 29% (CL, 15-43%) and 9% (CL, 0-18%), respectively (P = 0.025). No @entity0 developed @entity4 @entity3 . These findings support the role of @entity8 in first line chemotherapy for @entity2 . AVE is among the more efficacious regimens for @entity2 and also has a relatively low @entity1 .

title: A prospective randomised study in limited disease small cell carcinoma-- @entity4 and @entity7 plus either XXXX or @entity8 .

answer: @entity5


abstract: CONCLUSION: @entity9 is a chronic, specific, granuloma of the nose and other parts of the respiratory system. The disease is endemic in Egypt and many other countries. The causative organism is @entity8 bacillus, proved by fulfilling Koch's postulates. The mode of infection is not known and its worldwide irregular geographical distribution is not understood. Lines of treatment are unsatisfactory and a tendency for recurrence is the rule. OBJECTIVES: Our aim was to study the clinical presentation, microbiology, pathological staging, follow-up, and lines of treatment of new @entity9 @entity0 admitted or seen at Alexandria Main University Hospital from January 1999 until January 2009. METHODS: Demographic data and the results of clinical, bacteriological, and histological examinations were reviewed. Medical and surgical treatments were evaluated. Follow-up as regards the results of treatment and incidence of recurrence was assessed. RESULTS: Fifty-six @entity0 were included in the study. There were 26 males and 30 females, and 85% of @entity0 presented in the third and fourth decades of life. The nose was affected in 100% of @entity0 . Other regions affected were the nasopharynx in 13 @entity0 , palate in 7 @entity0 , skin in 2 @entity0 , larynx in 3 @entity0 , @entity5 in 17 @entity0 , nasolacrimal duct in 2 @entity0 , and premaxilla in 1 @entity0 . No lymph node affection was reported. @entity8 strain III was isolated from 100% of patients. Antibiotics used were a combination of @entity4 400 mg and @entity6 300 mg twice daily for 3 months. Since 2003, this was replaced by @entity7 500 mg twice daily for 3 months. Surgical procedures performed were removal of nasal granulations, @entity3 , @entity1 of @entity2 , tracheostomy, and repair of pharyngeal stenosis. Results were disappointing, as a large number of @entity0 did not attend for follow-up. A high incidence of recurrence was found, reaching up to 25% within 10 years.

title: XXXX : an updated experience through the last 10 years.

answer: @entity9


abstract: @entity7 was studied in a @entity0 model of experimental @entity8 using electrophysiological and ultrastructural techniques. Hearing impairment was monitored by auditory brain-stem evoked responses (ABERs) and concomitant structural lesions were identified by both transmission (TEM) and scanning (SEM) electron microscopy. @entity6 was induced by intra-cerebrospinal fluid injection of either @entity4 2073 and type K-12) or @entity2 type b. Auditory loss of approximately equal to 10 dB occurred in all @entity0 by about 10 hours post @entity1 and progressed in severity until by 20 h following @entity1 , @entity3 up to and > 60 dB were obtained. At levels of @entity3 < 20 dB ultrastructural damage to the organ of Corti was barely detectable. With greater levels of @entity3 , patchy structural damage to hair cells, synaptic nerve terminals, supporting cells and inner spiral sulcus cells and cells of the stria vascularis was clearly evident. Bacteria were found in scala tympani, the basilar membrane, the organ of Corti, scala media, the spiral ligament and at the margin of the stria vascularis. Evidence of @entity5 was found in some cochleas; erythrocytes were found in scala tympani, scala media, amongst hair cells and beneath the tectorial membrane. The results show that @entity3 is associated with bacterial invasion and damage to the organ of Corti and that the cause of @entity3 is likely to result from multiple lesions within the cochlea. Lesions to sensory cells almost certainly will produce permanent @entity3 . Lesions to supporting cells, nerve terminals and to stria vascularis may well produce only temporary @entity3 .

title: The cochlear lesion in experimental @entity8 of the XXXX .

answer: @entity0


abstract: @entity7 was studied in a @entity0 model of experimental @entity8 using electrophysiological and ultrastructural techniques. Hearing impairment was monitored by auditory brain-stem evoked responses (ABERs) and concomitant structural lesions were identified by both transmission (TEM) and scanning (SEM) electron microscopy. @entity6 was induced by intra-cerebrospinal fluid injection of either @entity4 2073 and type K-12) or @entity2 type b. Auditory loss of approximately equal to 10 dB occurred in all @entity0 by about 10 hours post @entity1 and progressed in severity until by 20 h following @entity1 , @entity3 up to and > 60 dB were obtained. At levels of @entity3 < 20 dB ultrastructural damage to the organ of Corti was barely detectable. With greater levels of @entity3 , patchy structural damage to hair cells, synaptic nerve terminals, supporting cells and inner spiral sulcus cells and cells of the stria vascularis was clearly evident. Bacteria were found in scala tympani, the basilar membrane, the organ of Corti, scala media, the spiral ligament and at the margin of the stria vascularis. Evidence of @entity5 was found in some cochleas; erythrocytes were found in scala tympani, scala media, amongst hair cells and beneath the tectorial membrane. The results show that @entity3 is associated with bacterial invasion and damage to the organ of Corti and that the cause of @entity3 is likely to result from multiple lesions within the cochlea. Lesions to sensory cells almost certainly will produce permanent @entity3 . Lesions to supporting cells, nerve terminals and to stria vascularis may well produce only temporary @entity3 .

title: The cochlear lesion in experimental XXXX of the @entity0 .

answer: @entity8


abstract: Haematopoietic necrosis of @entity1 ( @entity1 ) is caused by @entity2 (CyHV-2) and has caused huge economic losses in aquaculture worldwide. Currently the isolation and propagation of CyHV-2 in vitro is very difficult due to the lack of permissive cell lines. Studies on the pathogenesis of CyHV-2 have been hampered because the virus has not been extensively characterized. In this study, a novel cell line from the brain of @entity1 , denoted GiCB, has been established and characterized. Sustainable propagation of CyHV-2 in the GiCB cell line has been confirmed by virus @entity0 and titration, PCR, transmission electron microscopy, immunofluorescence assay and fluorescence in situ hybridization. The GiCB cells showed typical cytopathic effect by day 6 post- @entity0 with CyHV-2 including cell shrinkage, rounding, and cell fusion with cytoplasmic vacuolization. The virus titer reached 10(7.5    0.37)TCID      /ml and has been successfully passaged over 50 times in the GiCB cell line. Electron microscopy analysis revealed the complete replication of CyHV-2 in GiCB cells. CyHV-2-infected GiCB cells reacted strongly with polyclonal antibodies against CyHV-2 and CyHV-2 RNA in cells hybridized specifically with the virus RNA probes. Additionally, an experimental @entity0 demonstrated that CyHV-2 produced in GiCB cells caused 100% mortality in @entity1 . All the results provide solid evidence that the GiCB cell line is highly permissive for the isolation and propagation of CyHV-2. This is a significant advancement that will promote additional research on CyHV-2 @entity0 in fish in the future.

title: Establishment of a novel and highly permissive cell line for the efficient replication of XXXX (CyHV-2).

answer: @entity2


abstract: BACKGROUND: Nontraumatic @entity7 of the femoral head (ONFH) is a @entity4 caused by @entity1 of unknown etiology. A few studies have demonstrated trends in the number of @entity0 with ONFH. However, there are no data on temporal trends in characteristics such as age, gender, and causative factors. To investigate this, we examined data from a multicenter hospital-based sentinel monitoring system in Japan. METHODS: A total of 3041 newly-diagnosed ONFH @entity0 from 34 participating hospitals who were reported to the system from 1997-2011 were analyzed. We examined age at diagnosis, potential causative factors, and underlying diseases for which @entity0 received systemic @entity5 administration. Their temporal trends were assessed according to date of diagnosis in 5-year intervals (1997-2001, 2002-2006, and 2007-2011). RESULTS: The gender ratio and distribution of potential causative factors did not change. Regarding underlying diseases requiring @entity5 administration, the proportion of @entity0 with @entity6 decreased in males (10% to 6.4%) and in females (37% to 29%). Proportion of @entity0 with renal transplantation fell consistently across the study period in both males (3.8% to 1.2%) and females (3.2% to 0.8%). In contrast, the proportion of @entity0 receiving @entity2 for @entity3 (except asthma) significantly increased in both males (0.5% to 5.5%) and females (0.5% to 3.6%). CONCLUSIONS: This large descriptive study is the first to investigate temporal trends in the characteristics of ONFH, which provide useful information for future studies.

title: Temporal Trends in Characteristics of Newly Diagnosed Nontraumatic XXXX of the Femoral Head From 1997 to 2011: A Hospital-Based Sentinel Monitoring System in Japan.

answer: @entity7


abstract: WHAT IS KNOWN AND BACKGROUND: The introduction of vaccines has lead to a significant reduction in morbidity and mortality from diseases such as measles, @entity5 and @entity6 , as well as the eradication of @entity7 (Ertl HC, Xiang Z (1996) The Journal of Immunology, 156, 3579-3582). A recent vaccine approved by the Food and Drug Administration (FDA) is the recombinant quadrivalent @entity3 ) vaccine (Merck, @entity8  ). Concerns raised with this preventive measure include safety and efficacy issues as well as the financial implications. Furthermore, the use of the vaccine in @entity0 outside the currently approved age ranges and in adolescent @entity0 and @entity0 has also been a source of debate. OBJECTIVE: A review of two licensed HPV vaccines (Gardasil, Merck and Cervarix, GalxoSmithKline) in the light of these issues. METHODS: Literature searches were conducted using the MEDLINE (1966-December 2008) and PubMed databases in addition to the Centers for Disease Control and Prevention website. Bibliographies of selected references were also evaluated for relevant articles. Published guidelines and press releases were utilized as were the manufacturer's package inserts. The collection of information for this review was limited to the most recently available @entity0 data. RESULTS AND DISCUSSION: The HPV quadrivalent vaccine has been effective in the management of HPV by preventing vaccine subtype-related persistent @entity2 and @entity4 as evidenced by numerous clinical trials. It is also regarded as a generally safe and well-tolerated vaccine, based on an assessment of reported adverse events submitted through governmental databases and analyzed by independent researchers. The majority of adverse events were non-serious and the vaccine has not been conclusively implicated with serious events. The FDA continues to focus on routine post-marketing surveillance monitoring of reported adverse events. The bivalent vaccine has also been shown to be effective in reported trials. Its adverse effect profile also appears acceptable. WHAT IS NEW AND CONCLUSION: The HPV vaccines appear safe and effective. Additional clinical research on the vaccines on @entity0 outside the currently approved age ranges and in males is necessary. Studies on longer-term outcomes, including cervical @entity1 and the emergence of new viral genotypes are also necessary.

title: Quadrivalent XXXX ) vaccine: a review of safety, efficacy, and pharmacoeconomics.

answer: @entity3


abstract: BACKGROUND: @entity5 include @entity6 , bullous, abscessing and @entity2 . The risk factors predisposing @entity0 to local complications are not fully known. AIM: To examine local complications of @entity9 and to identify possible risk factors predisposing to their appearance. METHODS: Medical records from all @entity0 hospitalized with complications of @entity9 ( @entity8 , bullae, @entity2 ), admitted to the University Hospital of Heraklion between 1994 and 2002, were retrospectively studied. Clinical and laboratory data were compared with those from @entity0 with @entity9 without local complications. RESULTS: In total, 145 @entity0 were analysed, of whom 46 had @entity3 . Using bivariate analysis, the factors significantly associated with disease complications were found to be age >=  51 years, @entity1 , longer duration of local symptoms, and @entity4 on admission. During hospitalization, increased @entity7 level, isolation of pathogens, longer duration of @entity4 and/or presence of leucocytosis, absence of response to initial antibiotic therapy, and longer length of hospitalization were also associated with complications in the bivariate analysis. However, in the multivariate analysis, @entity1 (OR 4.489, 95% CI 1.719-11.725, P = 0.002) was the only independent factor associated with complicated @entity9 . CONCLUSIONS: This study found @entity1 to be an independent risk factor for local complications, of @entity9 . Hence, @entity1 @entity0 with @entity9 are prone to complications, and should be carefully evaluated because of the potential severity of disease and the increased risk of failure of empirical antimicrobial therapy.

title: XXXX : a study of associated risk factors.

answer: @entity5


abstract: OBJECTIVE: To develop and validate a shortened version of the Quality of Life in Childhood @entity3 Questionnaire (QOLCE). A secondary aim was to compare baseline risk factors predicting @entity2 ( @entity2 ) in @entity0 newly diagnosed with @entity3 , as identified using the original and shortened version. METHODS: Data came from the Health-Related Quality of Life in @entity0 with @entity3 Study (HERQULES, N = 373), a multicenter prospective cohort study. Principal component analysis reduced the number of items from the original QOLCE, and factor analysis was used to assess the factor structure of the shortened version. Convergent and divergent validity was assessed by correlating the @entity0 Health Questionnaire (CHQ) with the shortened QOLCE. Multiple regression identified risk factors at diagnosis for @entity2 at 24 months. RESULTS: A four-factor, higher-order, 55-item solution was obtained. A total of 21 items were removed. The final model represents functioning in four dimensions of @entity2 : Cognitive, Emotional, Social, and Physical. The shortened QOLCE demonstrated acceptable fit: Bentler's Comparative Fit Index = 0.944; Tucker-Lewis Index = 0.942; root mean square approximation = 0.058 (90% CI: 0.056-0.061); weighted root mean square residuals (WRMR) = 1.582, and excellent internal consistency (a = 0.96, subscales a > 0.80). Factor loadings were good (first-order:    = 0.66-0.93; higher-order    = 0.66-0.85; p < 0.001 for all). The shortened QOLCE scores correlated strongly with similar subscales of the @entity0 Health Questionnaire (   = 0.38-0.70) while correlating weakly with dissimilar subscales (   = 0.30-0.31). While controlling for @entity2 at diagnosis, predictors for better @entity2 at 24 months were the following: no cognitive problems reported (p = 0.001), better family functioning (p = 0.014), fewer family demands (p = 0.008), with an interaction between baseline @entity1 (p = 0.011). SIGNIFICANCE: Results offer initial evidence regarding reliability and validity of the proposed 55-item shortened version of the QOLCE (QOLCE-55). The QOLCE-55 produced results on risk factors consistent with those found using the original measure. Given the fewer items, QOLCE-55 may be a viable option reducing respondent burden when assessing @entity2 in @entity0 with @entity3 .

title: Development and assessment of a shortened Quality of Life in Childhood XXXX Questionnaire (QOLCE-55).

answer: @entity3


abstract: BACKGROUND: Diagnostic accuracy of MRI in predicting @entity0 size: comparative analysis of @entity0 size byMRI vs histopathological assessment. PURPOSE: Tumor size is one of the most important factors in making a clinical and pathological assessment of @entity0 . The purpose of this study is to evaluate if MRI imaging is helpful for the surgeon in the preoperative accurate assessment of @entity2 size. METHODS: We retrospectively reviewed the charts of 124 @entity1 who were diagnosed or managed at the Saint Francis /Mt. Sinai Regional @entity2 Center. We then compared the preoperative @entity2 size with the histopathological @entity2 size obtained at surgical resection. @entity2 were divided into four histological groups: @entity3 ( @entity3 ), @entity4 ( @entity4 ), @entity5 ( @entity5 ), and @entity2 (including mucinous, papillary, tubular, and apocrine @entity0 ). MRI measurement of @entity2 size was compared against the reference size obtained from the microscopic measurement of the largest diameter of @entity2 . Concordance was defined as a difference  <= 0.5 cm between MRI and pathology. RESULTS: A total of 124 @entity1 with 147 @entity0 were included in our study. The mean age was 59.8    12.72 years. Histologically, there were 81 @entity3 (55.10%), 35 @entity5 (23.81%), 15 @entity4 (10.20%), and 16 @entity2 (10.88%). Out of 147 @entity2 , 55.78% showed concordance of MRI and pathologic @entity2 size within 0.5 cm. MRI overestimated 31.97% and underestimated 12.24% of @entity2 . CONCLUSION: Breast MRI provides an additional tool for preoperative assessment of @entity2 size. In our study, we noted 56% concordance between MRI with pathological @entity2 size within 0.5 cm. Several factors, including grading of @entity2 , @entity2 type, and size, strongly affect the accuracy of MRI in the preoperative assessment of @entity2 size. High-grade @entity2 and @entity5 are the two strongest negative factors resulting in overestimation of @entity2 size on MRI.

title: Diagnostic Accuracy of MRI in Predicting XXXX Size: Comparative Analysis of MRI vs Histopathological Assessed @entity0 Size.

answer: @entity0


abstract: BACKGROUND: Diagnostic accuracy of MRI in predicting @entity0 size: comparative analysis of @entity0 size byMRI vs histopathological assessment. PURPOSE: Tumor size is one of the most important factors in making a clinical and pathological assessment of @entity0 . The purpose of this study is to evaluate if MRI imaging is helpful for the surgeon in the preoperative accurate assessment of @entity2 size. METHODS: We retrospectively reviewed the charts of 124 @entity1 who were diagnosed or managed at the Saint Francis /Mt. Sinai Regional @entity2 Center. We then compared the preoperative @entity2 size with the histopathological @entity2 size obtained at surgical resection. @entity2 were divided into four histological groups: @entity3 ( @entity3 ), @entity4 ( @entity4 ), @entity5 ( @entity5 ), and @entity2 (including mucinous, papillary, tubular, and apocrine @entity0 ). MRI measurement of @entity2 size was compared against the reference size obtained from the microscopic measurement of the largest diameter of @entity2 . Concordance was defined as a difference  <= 0.5 cm between MRI and pathology. RESULTS: A total of 124 @entity1 with 147 @entity0 were included in our study. The mean age was 59.8    12.72 years. Histologically, there were 81 @entity3 (55.10%), 35 @entity5 (23.81%), 15 @entity4 (10.20%), and 16 @entity2 (10.88%). Out of 147 @entity2 , 55.78% showed concordance of MRI and pathologic @entity2 size within 0.5 cm. MRI overestimated 31.97% and underestimated 12.24% of @entity2 . CONCLUSION: Breast MRI provides an additional tool for preoperative assessment of @entity2 size. In our study, we noted 56% concordance between MRI with pathological @entity2 size within 0.5 cm. Several factors, including grading of @entity2 , @entity2 type, and size, strongly affect the accuracy of MRI in the preoperative assessment of @entity2 size. High-grade @entity2 and @entity5 are the two strongest negative factors resulting in overestimation of @entity2 size on MRI.

title: Diagnostic Accuracy of MRI in Predicting @entity0 Size: Comparative Analysis of MRI vs Histopathological Assessed XXXX Size.

answer: @entity0


abstract: @entity1 ( @entity1 ) is the most common @entity2 . MicroRNAs (miRNAs) are a class of endogenously expressed small non-coding RNAs that are strongly implicated in cancerous processes. However, our current understanding of the biological role of miRNAs in @entity1 remains incomplete. In the present study, @entity5 was markedly downregulated in @entity1 cell lines and clinical specimens. Low-level expression of @entity5 was significantly associated with distant @entity0 and poor prognosis. Functional studies demonstrated that ectopic expression of @entity5 suppresses tumor cell proliferation and @entity0 in vitro as well as in vivo. Furthermore, we identified Rho-associated kinases 1 and 2 ( @entity3 and @entity4 ) as direct targets for @entity5 binding, resulting in suppression of their expression. Exogenous expression of @entity3 or @entity4 in 143B- @entity5 cells partially restored @entity5 -inhibited cell proliferation and invasion. In clinical @entity1 specimens, @entity3 and @entity4 levels were elevated, relative to that in paired normal bone tissues, and inversely correlated with @entity5 expression. Taken together, @entity5 suppresses @entity1 progression by directly downregulating @entity3 and @entity4 expression, and may be a promising therapeutic target for @entity1 .

title: MicroRNA-144 suppresses XXXX growth and @entity0 by targeting @entity3 and @entity4 .

answer: @entity1


abstract: @entity1 ( @entity1 ) is the most common @entity2 . MicroRNAs (miRNAs) are a class of endogenously expressed small non-coding RNAs that are strongly implicated in cancerous processes. However, our current understanding of the biological role of miRNAs in @entity1 remains incomplete. In the present study, @entity5 was markedly downregulated in @entity1 cell lines and clinical specimens. Low-level expression of @entity5 was significantly associated with distant @entity0 and poor prognosis. Functional studies demonstrated that ectopic expression of @entity5 suppresses tumor cell proliferation and @entity0 in vitro as well as in vivo. Furthermore, we identified Rho-associated kinases 1 and 2 ( @entity3 and @entity4 ) as direct targets for @entity5 binding, resulting in suppression of their expression. Exogenous expression of @entity3 or @entity4 in 143B- @entity5 cells partially restored @entity5 -inhibited cell proliferation and invasion. In clinical @entity1 specimens, @entity3 and @entity4 levels were elevated, relative to that in paired normal bone tissues, and inversely correlated with @entity5 expression. Taken together, @entity5 suppresses @entity1 progression by directly downregulating @entity3 and @entity4 expression, and may be a promising therapeutic target for @entity1 .

title: MicroRNA-144 suppresses @entity1 growth and @entity0 by targeting @entity3 and XXXX .

answer: @entity4


abstract: @entity1 ( @entity1 ) is the most common @entity2 . MicroRNAs (miRNAs) are a class of endogenously expressed small non-coding RNAs that are strongly implicated in cancerous processes. However, our current understanding of the biological role of miRNAs in @entity1 remains incomplete. In the present study, @entity5 was markedly downregulated in @entity1 cell lines and clinical specimens. Low-level expression of @entity5 was significantly associated with distant @entity0 and poor prognosis. Functional studies demonstrated that ectopic expression of @entity5 suppresses tumor cell proliferation and @entity0 in vitro as well as in vivo. Furthermore, we identified Rho-associated kinases 1 and 2 ( @entity3 and @entity4 ) as direct targets for @entity5 binding, resulting in suppression of their expression. Exogenous expression of @entity3 or @entity4 in 143B- @entity5 cells partially restored @entity5 -inhibited cell proliferation and invasion. In clinical @entity1 specimens, @entity3 and @entity4 levels were elevated, relative to that in paired normal bone tissues, and inversely correlated with @entity5 expression. Taken together, @entity5 suppresses @entity1 progression by directly downregulating @entity3 and @entity4 expression, and may be a promising therapeutic target for @entity1 .

title: MicroRNA-144 suppresses @entity1 growth and XXXX by targeting @entity3 and @entity4 .

answer: @entity0


abstract: @entity1 ( @entity1 ) is the most common @entity2 . MicroRNAs (miRNAs) are a class of endogenously expressed small non-coding RNAs that are strongly implicated in cancerous processes. However, our current understanding of the biological role of miRNAs in @entity1 remains incomplete. In the present study, @entity5 was markedly downregulated in @entity1 cell lines and clinical specimens. Low-level expression of @entity5 was significantly associated with distant @entity0 and poor prognosis. Functional studies demonstrated that ectopic expression of @entity5 suppresses tumor cell proliferation and @entity0 in vitro as well as in vivo. Furthermore, we identified Rho-associated kinases 1 and 2 ( @entity3 and @entity4 ) as direct targets for @entity5 binding, resulting in suppression of their expression. Exogenous expression of @entity3 or @entity4 in 143B- @entity5 cells partially restored @entity5 -inhibited cell proliferation and invasion. In clinical @entity1 specimens, @entity3 and @entity4 levels were elevated, relative to that in paired normal bone tissues, and inversely correlated with @entity5 expression. Taken together, @entity5 suppresses @entity1 progression by directly downregulating @entity3 and @entity4 expression, and may be a promising therapeutic target for @entity1 .

title: MicroRNA-144 suppresses @entity1 growth and @entity0 by targeting XXXX and @entity4 .

answer: @entity3


abstract: OBJECTIVES: This study sought to evaluate procedural and clinical outcomes among @entity0 undergoing chronic total occlusion (CTO) percutaneous coronary intervention (PCI) using contemporary methods and @entity8 -eluting stents (EES). BACKGROUND: Limited studies have detailed the procedural and late-term safety and efficacy of CTO revascularization among multiple centers applying modern techniques and with newer-generation drug-eluting stents. METHODS: Among 20 centers, 250 consecutive @entity0 were enrolled for attempted CTO PCI. Procedural and in-hospital clinical outcomes were examined in addition to the 1-year primary endpoint of @entity3 , @entity6 , and @entity2 revascularization (major adverse @entity4 [MACE]). RESULTS: @entity2 , and procedural characteristics included prior bypass surgery: 9.9%; @entity1 : 40.1%; lesion length: 36.1    18.5 mm; and stent length: 51.7    27.2 mm. Procedural success, defined as guidewire recanalization with no in-hospital MACE, was 96.4%. Success with antegrade-only methods was 97.9% and 86.2% by retrograde/combined methods, respectively. Compared with a pre-specified performance goal derived from 6 prior CTO drug-eluting stent trials (1-year MACE: 24.4%), treatment with EES was associated with significantly lower composite adverse events for both intent-to-treat (18.5%, 1-sided upper confidence interval: 23.4%, p = 0.025) and per-protocol populations (8.2%, 1-sided upper confidence interval: 12.3%, p < 0.0001). @entity2 revascularization at 1 year was 6.3%. Dual antiplatelet therapy adherence was 53.9% at 1 year, yet subacute definite stent @entity7 occurred in only 2 @entity0 (0.9%), and late probable stent @entity7 occurred in 1 @entity0 (0.5%). CONCLUSIONS: In a multicenter registration trial representing contemporary technique and EES, favorable procedural success and late-term clinical outcomes support CTO PCI in a @entity0 population with high lesion complexity. (EXPERT CTO: Evaluation of the XIENCE PRIME LL and XIENCE Nano Everolimus Eluting Coronary Stent Coronary Stents, Performance, and Technique in @entity5 ; NCT01435031).

title: Safety and Effectiveness of XXXX -Eluting Stents in Chronic Total Coronary Occlusion Revascularization: Results From the EXPERT CTO Multicenter Trial (Evaluation of the XIENCE Coronary Stent, Performance, and Technique in @entity5 ).

answer: @entity8


abstract: OBJECTIVES: This study sought to evaluate procedural and clinical outcomes among @entity0 undergoing chronic total occlusion (CTO) percutaneous coronary intervention (PCI) using contemporary methods and @entity8 -eluting stents (EES). BACKGROUND: Limited studies have detailed the procedural and late-term safety and efficacy of CTO revascularization among multiple centers applying modern techniques and with newer-generation drug-eluting stents. METHODS: Among 20 centers, 250 consecutive @entity0 were enrolled for attempted CTO PCI. Procedural and in-hospital clinical outcomes were examined in addition to the 1-year primary endpoint of @entity3 , @entity6 , and @entity2 revascularization (major adverse @entity4 [MACE]). RESULTS: @entity2 , and procedural characteristics included prior bypass surgery: 9.9%; @entity1 : 40.1%; lesion length: 36.1    18.5 mm; and stent length: 51.7    27.2 mm. Procedural success, defined as guidewire recanalization with no in-hospital MACE, was 96.4%. Success with antegrade-only methods was 97.9% and 86.2% by retrograde/combined methods, respectively. Compared with a pre-specified performance goal derived from 6 prior CTO drug-eluting stent trials (1-year MACE: 24.4%), treatment with EES was associated with significantly lower composite adverse events for both intent-to-treat (18.5%, 1-sided upper confidence interval: 23.4%, p = 0.025) and per-protocol populations (8.2%, 1-sided upper confidence interval: 12.3%, p < 0.0001). @entity2 revascularization at 1 year was 6.3%. Dual antiplatelet therapy adherence was 53.9% at 1 year, yet subacute definite stent @entity7 occurred in only 2 @entity0 (0.9%), and late probable stent @entity7 occurred in 1 @entity0 (0.5%). CONCLUSIONS: In a multicenter registration trial representing contemporary technique and EES, favorable procedural success and late-term clinical outcomes support CTO PCI in a @entity0 population with high lesion complexity. (EXPERT CTO: Evaluation of the XIENCE PRIME LL and XIENCE Nano Everolimus Eluting Coronary Stent Coronary Stents, Performance, and Technique in @entity5 ; NCT01435031).

title: Safety and Effectiveness of @entity8 -Eluting Stents in Chronic Total Coronary Occlusion Revascularization: Results From the EXPERT CTO Multicenter Trial (Evaluation of the XIENCE Coronary Stent, Performance, and Technique in XXXX ).

answer: @entity5


abstract: BACKGROUND CONTEXT: Although stand-alone cages were advocated to be superior to plate-cage construct (PCC) because of comparable clinical outcomes and fewer plate-related complications, cage dislocation and subsidence were frequently mentioned in multilevel fusion. There are some concerns about whether these issues can be effectively prevented in multilevel anterior cervical discectomy and fusion (ACDF) by stand-alone anchored spacer (SAAS). PURPOSE: The aim was to compare clinical outcomes, radiologic parameters, and complications of PCC and SAAS in the treatment of three-level cervical spondylotic @entity2 (CSM). STUDY DESIGN/SETTING: This was a retrospective comparative study. @entity0 SAMPLE: A total of 38 consecutive @entity0 with three-level CSM (ACDF with PCC, 20 @entity0 ; ACDF with SAAS, 18 @entity0 ) were reviewed. OUTCOME MEASURES: Clinical outcomes were assessed using Japanese Orthopaedic Association and Neck Disability Index. The radiologic evaluations included cervical alignment (CA), segmental angle (SA), @entity1 ( @entity1 ), and incidence of subsidence. METHODS: All the aforementioned parameters were compared before and after surgery between two groups. Besides, the aforementioned results were also compared between the two groups. The complications were also recorded. RESULTS: The mean follow-up period was 30.3 months. No significant differences were observed in clinical outcomes between the two groups (p>.05). Additionally, no significant differences existed in fusion rate between the two groups. There were significant differences in @entity1 of SA and CA and correction of SA between the two groups (p<.05). Besides, the incidence of subsidence (9 of 54 levels, 16.7%) was recorded in the SAAS group, and the potential of SAAS to reduce the incidence of @entity1 was not proven. No other complications were observed in this study. CONCLUSIONS: In the surgical treatment of three-level CSM, PCC is superior to SAAS in correction and maintenance of SA and avoiding cage subsidence, although the technique of ACDF with SAAS yielded encouraging clinical outcomes and high fusion rate.

title: Comparison of plate-cage construct and stand-alone anchored spacer in the surgical treatment of three-level cervical spondylotic XXXX : a preliminary clinical study.

answer: @entity2


abstract: BACKGROUND: Nutritional status and @entity3 have not been studied to a significant extent in @entity2 ( @entity2 ). The aim of this study was to determine the trends in anthropometric indices and assess their impact on @entity0 with @entity2 . METHODS: We prospectively studied in 56 @entity0 with @entity2 , the @entity1 ( @entity1 ), mid-arm circumference (MAC), mid-arm muscle circumference (MAMC), and other factors, and their relationship to clinical @entity4 and mortality. RESULTS: The median MAC decreased significantly from 29.3 cm (interquartile range [IQR] 28-31 cm) at admission to 27 cm (IQR 26-29 cm) at 1-week (P < 0.001). The median @entity1 decreased significantly from 34 mm (IQR 30-40 mm) at admission to 30 mm (IQR 25-35 mm) at 1-week (P < 0.001). MAMC values did not show a significant change over a week. The @entity0 who developed clinical @entity4 had significantly higher median admission @entity1 of 40 mm (IQR 35-45 mm), compared to the median admission @entity1 of 35 mm (IQR 30-40 mm) among those who did not develop @entity4 (P = 0.03). MAMC values did not differ significantly in relation to @entity4 . @entity0 who expired by 3 months had significantly greater fall in median MAMC values at 1-week (7.7% [IQR 5.2-11.5%]), compared to the fall in median MAMC values at 1-week among those who were alive at 3 months (2.6% [IQR 2.1-6.6%]) [P = 0.03]. However, the fall in @entity1 values did not differ significantly in relation to mortality. In multivariate analysis, only the admission @entity1 , Hunt and Hess and Fisher grades had a significant association with @entity4 . This association was independent of other prognostic factors and of each other. CONCLUSION: Excessive @entity3 of @entity0 , measured as an increased @entity1 value, is significantly associated with clinical @entity4 independent of other prognostic factors, while fall in MAMC, indicating somatic protein catabolism, has some impact on mortality.

title: Study of trends in anthropometric nutritional indices and the impact of XXXX among @entity0 of @entity2 .

answer: @entity3


abstract: BACKGROUND: Nutritional status and @entity3 have not been studied to a significant extent in @entity2 ( @entity2 ). The aim of this study was to determine the trends in anthropometric indices and assess their impact on @entity0 with @entity2 . METHODS: We prospectively studied in 56 @entity0 with @entity2 , the @entity1 ( @entity1 ), mid-arm circumference (MAC), mid-arm muscle circumference (MAMC), and other factors, and their relationship to clinical @entity4 and mortality. RESULTS: The median MAC decreased significantly from 29.3 cm (interquartile range [IQR] 28-31 cm) at admission to 27 cm (IQR 26-29 cm) at 1-week (P < 0.001). The median @entity1 decreased significantly from 34 mm (IQR 30-40 mm) at admission to 30 mm (IQR 25-35 mm) at 1-week (P < 0.001). MAMC values did not show a significant change over a week. The @entity0 who developed clinical @entity4 had significantly higher median admission @entity1 of 40 mm (IQR 35-45 mm), compared to the median admission @entity1 of 35 mm (IQR 30-40 mm) among those who did not develop @entity4 (P = 0.03). MAMC values did not differ significantly in relation to @entity4 . @entity0 who expired by 3 months had significantly greater fall in median MAMC values at 1-week (7.7% [IQR 5.2-11.5%]), compared to the fall in median MAMC values at 1-week among those who were alive at 3 months (2.6% [IQR 2.1-6.6%]) [P = 0.03]. However, the fall in @entity1 values did not differ significantly in relation to mortality. In multivariate analysis, only the admission @entity1 , Hunt and Hess and Fisher grades had a significant association with @entity4 . This association was independent of other prognostic factors and of each other. CONCLUSION: Excessive @entity3 of @entity0 , measured as an increased @entity1 value, is significantly associated with clinical @entity4 independent of other prognostic factors, while fall in MAMC, indicating somatic protein catabolism, has some impact on mortality.

title: Study of trends in anthropometric nutritional indices and the impact of @entity3 among @entity0 of XXXX .

answer: @entity2


abstract: BACKGROUND: Nutritional status and @entity3 have not been studied to a significant extent in @entity2 ( @entity2 ). The aim of this study was to determine the trends in anthropometric indices and assess their impact on @entity0 with @entity2 . METHODS: We prospectively studied in 56 @entity0 with @entity2 , the @entity1 ( @entity1 ), mid-arm circumference (MAC), mid-arm muscle circumference (MAMC), and other factors, and their relationship to clinical @entity4 and mortality. RESULTS: The median MAC decreased significantly from 29.3 cm (interquartile range [IQR] 28-31 cm) at admission to 27 cm (IQR 26-29 cm) at 1-week (P < 0.001). The median @entity1 decreased significantly from 34 mm (IQR 30-40 mm) at admission to 30 mm (IQR 25-35 mm) at 1-week (P < 0.001). MAMC values did not show a significant change over a week. The @entity0 who developed clinical @entity4 had significantly higher median admission @entity1 of 40 mm (IQR 35-45 mm), compared to the median admission @entity1 of 35 mm (IQR 30-40 mm) among those who did not develop @entity4 (P = 0.03). MAMC values did not differ significantly in relation to @entity4 . @entity0 who expired by 3 months had significantly greater fall in median MAMC values at 1-week (7.7% [IQR 5.2-11.5%]), compared to the fall in median MAMC values at 1-week among those who were alive at 3 months (2.6% [IQR 2.1-6.6%]) [P = 0.03]. However, the fall in @entity1 values did not differ significantly in relation to mortality. In multivariate analysis, only the admission @entity1 , Hunt and Hess and Fisher grades had a significant association with @entity4 . This association was independent of other prognostic factors and of each other. CONCLUSION: Excessive @entity3 of @entity0 , measured as an increased @entity1 value, is significantly associated with clinical @entity4 independent of other prognostic factors, while fall in MAMC, indicating somatic protein catabolism, has some impact on mortality.

title: Study of trends in anthropometric nutritional indices and the impact of @entity3 among XXXX of @entity2 .

answer: @entity0


abstract: TOPIC: @entity2 are the most common mental health concern for youth. Unfortunately, a substantial number of @entity0 and adolescents do not respond positively to current evidence-based interventions and/or relapse. As pediatric @entity2 are fundamentally a systemic phenomenon, focusing on the ways in which parents become involved in their @entity0 's @entity2 may be a promising alternative approach to treatment. PURPOSE: To inform @entity1 mental health nurse practitioners (PMHNPs) about the phenomenology, associated neurobiology, and assessment of family accommodation (FA) as well as clinical interventions targeting FA. FA refers to ways that parents adapt their own behaviors to reduce their @entity0 's @entity2 . SOURCES USED: A literature search was performed using Psyc-INFO and PubMed. CONCLUSIONS: Current findings indicate a high prevalence of FA associated with pediatric @entity2 . FA has a potentially deleterious impact on @entity3 and treatment response and is associated with greater caregiver burden. Potential neurobiological underpinnings of FA include dysregulation of parent cortico-limbic circuitry and the oxytocinergic system. PMHNPs are in a unique position to identify families engaged in problematic FA, educate their clientele, provide psychotherapy services with the goal of reducing FA, and consult with multidisciplinary team members.

title: Family Accommodation of XXXX and Adolescent Anxiety: Mechanisms, Assessment, and Treatment.

answer: @entity0


abstract: OBJECTIVE: To evaluate the clinical value of Solitaire AB stents in the embolization of @entity2 . @entity0 AND METHODS: Solitaire AB stents were applied in treating 69 @entity3 in 65 @entity0 . Among them, there were 67 "wide neck" @entity3 and two " @entity1 " @entity3 . Of the 69 @entity3 , there were 40 @entity3 in the posterior communicating artery, 13 in the ophthalmic artery segment, one in the cavernous segment of the internal carotid artery, three in the middle cerebral artery, one in the anterior communicating artery, eight in the vertebral artery, and three in the basilar artery. The treatment techniques used included transposition, parallel technique, post-release technique, and salvage stenting. RESULTS: Immediate angiographic results showed complete @entity5 in 63 cases, residual @entity3 neck in two cases and partial @entity6 in four cases. Intraoperative @entity8 was found in two cases, of which @entity4 was stopped with continued filling. Postoperative @entity7 cerebrospinal fluid shunt was performed in one case. Coil shift was observed in two cases. No further @entity4 cases occurred during the clinical follow-up. Of 14 @entity0 who had undergone angiographic follow-up, three cases had recurrence and one case received re-embolization. CONCLUSIONS: Solitaire AB stent is clinically feasible when applied for the embolization of @entity2 using multiple techniques and, thus, warrants clinical promotion.

title: Clinical application of solitaire AB stents in the embolization of XXXX .

answer: @entity2


abstract: OBJECTIVE: To determine if preoperative lumbar drain (LD) use reduces the incidence of postoperative cerebrospinal fluid (CSF) leak in @entity0 undergoing @entity3 resection. METHODS: Retrospective review of 282 @entity0 presenting for @entity3 resection between 2005 and 2014. RESULTS: Two hundred and eighty-two @entity0 had a mean @entity1 size of 19.1 mm    10.2 mm. Twenty-nine (10.3%) @entity0 developed a postoperative CSF leak. Two hundred and twenty @entity0 (78.0%) received a preoperative LD, and 20 (9.1%) developed a CSF leak. Sixty-two (22.0%) @entity0 did not receive a preoperative LD, and 9 (14.5%) developed a CSF leak. No significant difference in CSF leak frequency was observed with use versus no use of a LD (P = .23). Fifteen (5.3%) @entity0 with an LD placed had a complication related to the LD. No significant difference in CSF leak frequency was observed with @entity0 age, @entity2 type-2 diagnosis, @entity1 size, or sidedness. CONCLUSIONS: Postoperative CSF leaks are among the most common complications of @entity3 microsurgery. No formal guidelines exist for elective placement of a preoperative LD to lower the incidence of CSF leaks. Our reported CSF leak incidence with preoperative LD placement is not significantly lower than without LD use, and there is a complication rate associated with LD use.

title: Preoperative Lumbar Drain Use During XXXX Surgery and Effect on CSF Leak Incidence.

answer: @entity3


abstract: OBJECTIVE: To evaluate whether breastfeeding affected the immunogenicity and/or efficacy of candidate rhesus- @entity0 rotavirus reassortant vaccines. METHODS: A total of 989 healthy @entity0 between 4 and 26 weeks of age were enrolled into a 23-center, prospective, randomized, double-masked, controlled study of the safety, immunogenicity, and efficacy of three doses (4 x 10(4) plaque-forming units) of monovalent rhesus- @entity0 viral protein 7, or G, serotype 1 reassortant vaccine, ( @entity1 -S1) or tetravalent vaccine ( @entity1 -TV) consisting of rhesus- @entity0 reassortant G serotypes 1, 2, and 4, and the parent @entity1 G serotype 3. Vaccine efficacy was compared in the breastfed and nonbreastfed @entity0 as well as seroconversion rates and postvaccination geometric mean titers (GMTs) of neutralizing antibodies to @entity0 serotypes 1, 2, 3, and 4, @entity1 , and immunoglobulin A to @entity1 . GMTs in the two feeding groups were compared with and without adjustment for age at initiation of vaccination, prevaccination antibody titers, and the age and prevaccination titer interaction. RESULTS: The seroconversion rates to both vaccines by one or more assays were similar for the breastfed and the nonbreastfed groups ( @entity1 -S1, 84% and 85%, respectively; @entity1 -TV, 94% and 93%, respectively). There were no significant differences in postvaccination GMTs to either vaccine, measured by any serologic assay, in the two feeding groups. The efficacy of the @entity1 -S1 vaccine was not significantly lower among the breastfed @entity0 than the nonbreastfed @entity0 (28% and 39%, respectively). @entity1 -TV, which is the vaccine being further evaluated for licensure, was equally protective in breastfed and nonbreastfed @entity0 (50% and 51%, respectively). Logistic regression analysis, taking into account differences in age at vaccination and day 1 titer, revealed no evidence of differential vaccine efficacy in the two feeding groups for either vaccine. CONCLUSIONS: These results indicate that the @entity1 -TV vaccine, given as three doses of 4 x 10(4) plaque-forming units, induces similar seroresponses and protection in breastfed and nonbreastfed US @entity0 .

title: Comparison of immunogenicity and efficacy of rhesus rotavirus reassortant vaccines in breastfed and nonbreastfed XXXX . US Rotavirus Vaccine Efficacy Group.

answer: @entity0


abstract: UNASSIGNED: Various environmental stresses limit plant growth, development, and reproductive success. Plants have therefore evolved sophisticated adaptive responses to deal with environmental challenges. The responses of plants to environmental stresses are mainly mediated by @entity1 ( @entity2 )-dependent and @entity2 -independent signaling pathways. While these two pathways have been implicated to play discrete roles in abiotic stress responses, accumulating evidence suggests that they are also intertwined. Here, we report that an R2R3-type MYB transcription factor, @entity4 , integrates the @entity2 and cold signaling pathways. In addition to its role in @entity2 -mediated drought responses, @entity4 is also induced by cold stress in an @entity2 -independent manner and subsequently activates freezing tolerance. Notably, @entity4 regulates @entity0 ( @entity0 ) genes by binding to their promoters. The @entity0 proteins, in turn, interact with C-REPEAT BINDING FACTOR (CBF) upstream regulators, such as @entity5 ( @entity5 ), @entity6 , and @entity3 ( @entity3 ). The specific interactive networks of HHPs with the CBF upstream regulators are necessary to facilitate transcriptional activation of the CBF regulon under stressful conditions. Together, the @entity4 - @entity0 module integrates @entity2 -dependent and @entity2 -independent signals and activates the CBF pathway, ensuring plant adaptation to a wide range of adverse environmental fluctuations.

title: The @entity4 - @entity0 module integrates cold and XXXX signaling to activate the CBF-COR pathway in Arabidopsis.

answer: @entity1


abstract: UNASSIGNED: Various environmental stresses limit plant growth, development, and reproductive success. Plants have therefore evolved sophisticated adaptive responses to deal with environmental challenges. The responses of plants to environmental stresses are mainly mediated by @entity1 ( @entity2 )-dependent and @entity2 -independent signaling pathways. While these two pathways have been implicated to play discrete roles in abiotic stress responses, accumulating evidence suggests that they are also intertwined. Here, we report that an R2R3-type MYB transcription factor, @entity4 , integrates the @entity2 and cold signaling pathways. In addition to its role in @entity2 -mediated drought responses, @entity4 is also induced by cold stress in an @entity2 -independent manner and subsequently activates freezing tolerance. Notably, @entity4 regulates @entity0 ( @entity0 ) genes by binding to their promoters. The @entity0 proteins, in turn, interact with C-REPEAT BINDING FACTOR (CBF) upstream regulators, such as @entity5 ( @entity5 ), @entity6 , and @entity3 ( @entity3 ). The specific interactive networks of HHPs with the CBF upstream regulators are necessary to facilitate transcriptional activation of the CBF regulon under stressful conditions. Together, the @entity4 - @entity0 module integrates @entity2 -dependent and @entity2 -independent signals and activates the CBF pathway, ensuring plant adaptation to a wide range of adverse environmental fluctuations.

title: The XXXX - @entity0 module integrates cold and @entity1 signaling to activate the CBF-COR pathway in Arabidopsis.

answer: @entity4