abstract: BACKGROUND: A retrospective clinical analysis of @entity2 which contained a significant proportion of gemistocytes was carried out in order to evaluate their effect on prognosis, and other factors influencing prognosis. METHOD: From 253 consecutive cases of @entity0 in adults, 25 were selected who had more than 20% gemistocytes in every high-power field examined. 9 of these had @entity4 , the remainder did not. They were divided into two groups according to the proportion of gemistocytes; group A, contained more than 60% gemistocytes, and group B, had between 20 and 60% gemistocytes. TUNEL and immunohistochemical staining for PCNA, @entity3 , Ki-67, @entity1 were performed in the 20 available cases. FINDINGS: The median follow-up period was 46 months. There were 14 recurrences, with a median time to recurrence of 15 months. Thirteen repeat operations were performed in nine cases, and two cases showed recurring malignant transformation. The overall median survival time following diagnosis was 73 months and the 5-year survival rate was 52%. There were no significant differences in median survival between groups A and B with different proportions of gemistocytes. On the other hand the median survival of the @entity2 with @entity4 was 25 months, compared with 158 months for those without @entity4 (p=0.0005). The significant impact of @entity4 on survival persisted in both groups. There were no significant differences in immunohistochemical staining between the two groups, with the exception of staining for Ki-67 (means of the two groups: group A 1.40; group B 2.50). CONCLUSIONS: It is suggested that the proportion of gemistocytes does not itself affect prognosis.

title: The significance of gemistocytes in XXXX .

answer: @entity2


abstract: Mechanical load regulates ventricular growth, function, and structure from the earliest stages of cardiac morphogenesis through senescence. Dramatic changes in cardiac form and function have been defined for developing @entity0 , and changes in mechanical loading conditions can produce structural malformations such as @entity4 . To date, relatively little is known regarding the interactions between changes in mechanical load, morphogenesis, and the material properties of the embryonic heart. We tested the hypothesis that passive material properties in the embryonic heart change in response to altered mechanical load and that microtubules play an important role in this adaptive response. We measured biaxial passive stress-strain relations in left ventricular (LV) @entity1 in @entity3 embryos at Hamburger-Hamilton stage 27 following left atrial ligation (LAL) at stage 21 to reduce LV volume load and create @entity4 . Following LAL, myocardial stresses at given strains and circumferential stiffness increased versus control strips. Western blot analysis of LAL embryos showed an increase in both total and polymerized beta-tubulin and confocal microscopy confirmed an increase in microtubule density in the LV compact layer versus control. Following @entity5 treatment, LV stresses and stiffness normalized in LAL specimens and microtubule density following @entity5 was similar in LAL to control. In contrast, @entity2 treatment increased myocardial stresses and stiffness in control strips to levels beyond LAL specimens. Thus, the material properties of the developing myocardium are regulated by mechanical load and microtubules play a role in this adaptive response during cardiac morphogenesis.

title: Microtubule involvement in the adaptation to altered mechanical load in developing XXXX myocardium.

answer: @entity3


abstract: The @entity11 angiotensin system plays an important role in growth and development. Exposure of the neonate to an @entity7 inhibitor increases mortality and results in @entity5 and abnormal development. We have demonstrated that @entity7 inhibition in the developing kidney increases apoptosis and decreases cell proliferation, which may account for @entity0 . To evaluate the role of endogenous angiotensin in cardiac development, the relationship between @entity7 inhibition, cell proliferation, apoptosis, several modulators of apoptosis ( @entity9 , @entity13 , and clusterin) was examined in the developing @entity1 heart. Thirty-five newborn @entity1 pups were treated with @entity12 (30 mg/kg/d) or a vehicle (control group) for 7 d, and hearts were removed for rt-PCR and Western blotting of @entity9 , @entity13 , and clusterin. An additional 10 @entity1 pups were treated with @entity10 (10 mg/kg/d) or a vehicle, to serve as a @entity4 control. Cell proliferation was determined by @entity8 immunostaining, and apoptosis was detected using the total TUNEL technique. @entity12 treatment resulted in a 24% mortality, reduced body weight, and decreased heart weight (p < 0.05). @entity12 decreased proliferating myocytes by 23%, and reduced proliferating cardiac interstitial cells by 8.1% (p < 0.05). @entity12 also decreased myocytes apoptosis by 60%, but the proportion of myocytes undergoing apoptosis was 10-fold less than that of proliferating cells. Cardiac @entity9 mRNA, clusterin mRNA, @entity9 protein, and @entity13 protein content were not changed, but clusterin protein expression was decreased by @entity12 treatment. @entity10 did not alter cardiac cell proliferation or apoptosis. We conclude that @entity7 inhibition decreases cell turnover in the developing @entity1 heart, which may contribute to @entity3 . The loss of myocytes may lead to greater myocyte @entity6 and @entity2 during later life.

title: Angiotensin converting enzyme inhibition decreases cell turnover in the neonatal XXXX heart.

answer: @entity1


abstract: OBJECTIVE: To update the analysis of technical and biologic factors related to hepatic resection for colorectal @entity1 in a large single-institution series to identify important prognostic indicators and patterns of failure. SUMMARY BACKGROUND DATA: Surgical therapy for @entity2 metastatic to the liver is the only potentially curable treatment. Careful @entity0 selection of those with resectable liver-only metastatic disease is crucial to the success of surgical therapy. METHODS: Two hundred forty-four consecutive @entity0 undergoing curative hepatic resection for metastatic @entity2 were analyzed retrospectively. Variables examined included sex, stage of @entity3 , size of @entity5 (s), number of lesions, disease-free interval, ploidy, differentiation, preoperative @entity6 level, and operative factors such as resection margin, use of cryotherapy, intraoperative ultrasound, and @entity4 . RESULTS: Surgical margin, number of lesions, and @entity6 ( @entity6 ) levels significantly control prognosis. @entity0 with only one or two liver lesions, a 1-cm surgical margin, and low @entity6 levels have a 5-year disease-free survival rate of more than 30%. Disease-free interval, original stage, bilobar involvement, size of @entity1 , differentiation, and ploidy were not significant predictors of recurrence. The pattern of failure correlates with surgical margin. Routine use of intraoperative ultrasound resulted in an increased incidence of negative surgical margin during the period examined. CONCLUSIONS: Surgical resection or cryotherapy of hepatic @entity1 from @entity2 is safe and curable in appropriately selected @entity0 . Biologic factors, such as number of lesions and @entity6 levels, determine potential curability, and surgical margin governs the patterns of failure and outcome in potentially curable @entity0 . Optimization of selection criteria and surgical resection margins will improve outcome.

title: Surgical margin in hepatic resection for colorectal XXXX : a critical and improvable determinant of outcome.

answer: @entity1


abstract: PURPOSE: The purpose of this study was to ascertain family dynamics of Finnish @entity0 with severe @entity3 ( @entity3 ) on the basis of Barnhill's framework for healthy family functioning. DESIGN AND METHOD: This study used description and comparison and an interview-administered questionnaire and survey. SAMPLE: @entity0 were @entity0 with @entity3 and their family members (n = 65) living in the Tampere University Hospital catchment area. The sample consisted of families of home @entity1 therapy @entity0 (n = 36) and families of inpatients (n = 29). Families consisted of @entity0 and their family members. INSTRUMENTS: Data were collected from @entity0 by interview-administered questionnaires and from family members by survey. The instrument used was the Family Dynamics Measure 2, operationalized and tested by the American Family Research Group. RESULTS: Families of home @entity1 therapy @entity0 experienced significantly more mutuality (P =.03) and made decisions about their illness and life significantly more independently (P =.05) than families of inpatients. Families of home @entity1 therapy @entity0 handled change significantly more flexibly (P =.03) than families of inpatients. DISCUSSION: For the most part, families of both @entity0 groups functioned well, but overall family functioning was clearly better in families of home @entity1 therapy @entity0 . The sample included some @entity2 and even severely @entity2 families. The results of this study cannot be generalized beyond the study sample because of the small sample size, but they provide suggestions for developing the care of @entity0 with @entity3 and their families.

title: Impact of XXXX on family functioning.

answer: @entity3


abstract: BACKGROUND: @entity8 is an unusual pathogen in adults who are not pregnant. @entity8 @entity7 is a poorly defined entity because it is uncommon; in contrast to other @entity6 , it bears a high mortality rate. The aim of this study was to define its clinical, prognostic, and therapeutic profile on the basis of a series of 9 consecutive @entity0 . METHODS: We conducted a prospective and multicenter study of @entity0 with @entity3 in which 310 episodes were included. RESULTS: @entity8 grew in 9 @entity0 (3%) who had no valve prosthesis. All @entity0 except 1 had underlying diseases, and all @entity0 had serious complications; the most common complications were major emboli, @entity5 , and shock. The valve affected was the mitral valve in 4 @entity0 , the aortic valve in 2 @entity0 , both the mitral and aortic valves in 2 @entity0 , and the tricuspid valve in 1 @entity0 . All episodes were on native valves. @entity1 tended to be large (maximal diameter >10 mm in all @entity0 ), very mobile, and pedunculated. An abscess was found in 2 @entity0 , and a perforation of the valve developed in 3 @entity0 . Five @entity0 died (mortality rate, 56%), 3 of whom had received antibiotic therapy alone. The 4 @entity0 who survived underwent combined medical-surgical therapy. CONCLUSION: @entity8 @entity4 is @entity2 , and early surgery should be considered to prevent the destruction of valves and development of serious complications.

title: Clinical profile of @entity8 XXXX .

answer: @entity4


abstract: BACKGROUND: @entity8 is an unusual pathogen in adults who are not pregnant. @entity8 @entity7 is a poorly defined entity because it is uncommon; in contrast to other @entity6 , it bears a high mortality rate. The aim of this study was to define its clinical, prognostic, and therapeutic profile on the basis of a series of 9 consecutive @entity0 . METHODS: We conducted a prospective and multicenter study of @entity0 with @entity3 in which 310 episodes were included. RESULTS: @entity8 grew in 9 @entity0 (3%) who had no valve prosthesis. All @entity0 except 1 had underlying diseases, and all @entity0 had serious complications; the most common complications were major emboli, @entity5 , and shock. The valve affected was the mitral valve in 4 @entity0 , the aortic valve in 2 @entity0 , both the mitral and aortic valves in 2 @entity0 , and the tricuspid valve in 1 @entity0 . All episodes were on native valves. @entity1 tended to be large (maximal diameter >10 mm in all @entity0 ), very mobile, and pedunculated. An abscess was found in 2 @entity0 , and a perforation of the valve developed in 3 @entity0 . Five @entity0 died (mortality rate, 56%), 3 of whom had received antibiotic therapy alone. The 4 @entity0 who survived underwent combined medical-surgical therapy. CONCLUSION: @entity8 @entity4 is @entity2 , and early surgery should be considered to prevent the destruction of valves and development of serious complications.

title: Clinical profile of XXXX @entity4 .

answer: @entity8


abstract: OBJECTIVE: This study concerned sensory processing (post-stimulus late evoked potential components) in different parts of the @entity0 brain as related to a motor task (hand movement) in a cognitive paradigm (Contingent Negative Variation). The focus of the study was on the time and space distribution of middle and late post-stimulus evoked potential (EP) components, and on the processing of sensory information in the subcortical-cortical networks. METHODS: Stereoelectroencephalography (SEEG) recordings of the contingent negative variation ( @entity4 ) in an @entity2 with a motor task were taken from 30 @entity0 (27 @entity0 with drug-resistant @entity3 ; 3 @entity0 with chronic @entity1 ). The intracerebral recordings were taken from 337 cortical sites (primary sensorimotor area ( @entity5 ); supplementary motor area ( @entity7 ); the cingulate gyrus; the orbitofrontal, premotor and dorsolateral prefrontal cortices; the temporal cortex, including the amygdalohippocampal complex; the @entity6 ) and from subcortical structures (the basal ganglia and the posterior thalamus). The concurrent scalp recordings were obtained from 3 @entity0 in the thalamic group. In 4 @entity0 in the @entity3 group, scalp recordings were taken separately from the SEEG procedure. The middle and long latency evoked potentials following an auditory warning (S1) and a visual imperative (S2) stimuli were analyzed. The occurrences of EPs were studied in two time windows (200-300 ms; and over 300 ms) following S1 and S2. RESULTS: Following S1, a high frequency of EP with latencies over 200 ms was observed in the primary sensorimotor area, the supplementary motor area, the premotor cortex, the orbitofrontal cortex, the cingulate gyrus, some parts of the temporal lobe, the basal ganglia, the insula, and the posterior thalamus. Following S2, a high frequency of EP in both of the time windows over 200 ms was observed in the @entity5 , the @entity7 , the premotor and dorsolateral prefrontal cortex, the orbitofrontal cortex, the cingulate gyrus, the basal ganglia, the posterior thalamus, and in some parts of the temporal cortex. The concurrent scalp recordings in the thalamic group of @entity0 twice revealed potentials peaking approximately at 215 ms following S1. Following S2, EP occurred with latencies of 215 and 310 ms, respectively. Following S1, separate scalp recordings in 4 @entity0 in the @entity3 group displayed EP 3 times in the 'over 300 ms' time window. Following S2, EP were presented once in the '200-300 ms' time window and 3 times in the 'over 300 ms' time window. CONCLUSIONS: The @entity5 , the @entity7 , multiple sites of the frontal lobe, some parts of the temporal lobe, the cingulate gyrus, the basal ganglia, the insula, and the posterior thalamus all participate in a cortico-subcortical network that is important for the parallel cognitive processing of sensory information in a movement related task.

title: Cortical and subcortical distribution of middle and long latency auditory and visual evoked potentials in a cognitive ( XXXX ) paradigm.

answer: @entity4


abstract: Joint destruction, as evidenced by radiographic findings, is a significant problem for @entity0 suffering from @entity3 and @entity4 . Inherently irreversible and frequently progressive, the process of @entity1 begins at and even before the clinical onset of disease. However, @entity4 are heterogeneous in nature and not all @entity0 progress to @entity1 . It is therefore important to identify @entity0 susceptible to joint destruction in order to initiate more aggressive treatment as soon as possible and thereby potentially prevent irreversible @entity1 . At the same time, the high cost and potential side effects associated with aggressive treatment mean it is also important not to over treat @entity0 and especially those who, even if left untreated, would not progress to joint destruction. It is therefore clear that a protein biomarker signature that could predict @entity1 at an early stage would support more informed clinical decisions on the most appropriate treatment regimens for individual @entity0 . Although many candidate biomarkers for @entity3 have been reported in the literature, relatively few have reached clinical use and as a consequence the number of prognostic biomarkers used in rheumatology has remained relatively static for several years. It has become evident that a significant challenge in the transition of biomarker candidates to clinical diagnostic assays lies in the development of suitably robust biomarker assays, especially multiplexed assays, and their clinical validation in appropriate @entity0 sample cohorts. Recent developments in mass spectrometry-based targeted quantitative protein measurements have transformed our ability to rapidly develop multiplexed protein biomarker assays. These advances are likely to have a significant impact on the validation of biomarkers in the future. In this review, we have comprehensively compiled a list of candidate biomarkers in @entity3 , evaluated the evidence for their potential as biomarkers of @entity2 , and outlined how mass spectrometry-based targeted and multiplexed measurement of candidate biomarker proteins is likely to accelerate their clinical validation and the development of clinical diagnostic tests.

title: Early biomarkers of XXXX in @entity3 .

answer: @entity1


abstract: Joint destruction, as evidenced by radiographic findings, is a significant problem for @entity0 suffering from @entity3 and @entity4 . Inherently irreversible and frequently progressive, the process of @entity1 begins at and even before the clinical onset of disease. However, @entity4 are heterogeneous in nature and not all @entity0 progress to @entity1 . It is therefore important to identify @entity0 susceptible to joint destruction in order to initiate more aggressive treatment as soon as possible and thereby potentially prevent irreversible @entity1 . At the same time, the high cost and potential side effects associated with aggressive treatment mean it is also important not to over treat @entity0 and especially those who, even if left untreated, would not progress to joint destruction. It is therefore clear that a protein biomarker signature that could predict @entity1 at an early stage would support more informed clinical decisions on the most appropriate treatment regimens for individual @entity0 . Although many candidate biomarkers for @entity3 have been reported in the literature, relatively few have reached clinical use and as a consequence the number of prognostic biomarkers used in rheumatology has remained relatively static for several years. It has become evident that a significant challenge in the transition of biomarker candidates to clinical diagnostic assays lies in the development of suitably robust biomarker assays, especially multiplexed assays, and their clinical validation in appropriate @entity0 sample cohorts. Recent developments in mass spectrometry-based targeted quantitative protein measurements have transformed our ability to rapidly develop multiplexed protein biomarker assays. These advances are likely to have a significant impact on the validation of biomarkers in the future. In this review, we have comprehensively compiled a list of candidate biomarkers in @entity3 , evaluated the evidence for their potential as biomarkers of @entity2 , and outlined how mass spectrometry-based targeted and multiplexed measurement of candidate biomarker proteins is likely to accelerate their clinical validation and the development of clinical diagnostic tests.

title: Early biomarkers of @entity1 in XXXX .

answer: @entity3


abstract: PURPOSE: A previously published study demonstrated a pharmacogenetic association between the minor alleles of 2 @entity2 single nucleotide polymorphisms (SNPs) and greater improvement in visual acuity (VA) to treatment with ranibizumab, an @entity1 ( @entity1 ) drug, in @entity0 with neovascular @entity3 ( @entity3 ). We evaluated whether this association was replicated among @entity0 who participated in the Comparison of @entity3 Treatments Trials (CATT) or the Alternative Treatments to Inhibit @entity1 in @entity0 with Age-Related @entity4 (IVAN) trial. DESIGN: Cohort studies within randomized clinical trials. @entity0 : Eight hundred thirty-five @entity0 participating in CATT and 512 @entity0 participating in IVAN. METHODS: Each @entity0 was genotyped for the SNPs @entity5 and @entity6 in the @entity2 gene. MAIN OUTCOMES MEASURES: Mean change in VA from baseline to 1 year after initiation of treatment with ranibizumab or bevacizumab. Differences in VA response between the @entity0 group homozygous for the minor allele of each SNP and the other genotype groups were evaluated with analysis of variance. Differences in VA response by the number of minor alleles present for either SNP or both combined were evaluated with tests of linear trend. Analyses were conducted separately for CATT and IVAN @entity0 and with both the studies combined. RESULTS: No statistically significant difference in mean change in VA was identified between genotypes of either SNP (P >=  0.05). Furthermore, a stepwise analysis failed to show a significant interaction for either SNP based on the number of minor alleles present. The lack of association was similar in both the CATT and IVAN cohorts and whether the analysis combined @entity0 treated with either ranibizumab or bevacizumab or when restricted to @entity0 treated with ranibizumab only. CONCLUSIONS: The CATT and IVAN data do not support a pharmacogenetic association between the 2  @entity2 SNPs, @entity5 and @entity6 , and change in VA in response to anti- @entity1 therapy in @entity0 with @entity3 .

title: @entity2 Gene Polymorphisms and Response to Anti- XXXX Therapy in Age-Related @entity3 .

answer: @entity1


abstract: PURPOSE: A previously published study demonstrated a pharmacogenetic association between the minor alleles of 2 @entity2 single nucleotide polymorphisms (SNPs) and greater improvement in visual acuity (VA) to treatment with ranibizumab, an @entity1 ( @entity1 ) drug, in @entity0 with neovascular @entity3 ( @entity3 ). We evaluated whether this association was replicated among @entity0 who participated in the Comparison of @entity3 Treatments Trials (CATT) or the Alternative Treatments to Inhibit @entity1 in @entity0 with Age-Related @entity4 (IVAN) trial. DESIGN: Cohort studies within randomized clinical trials. @entity0 : Eight hundred thirty-five @entity0 participating in CATT and 512 @entity0 participating in IVAN. METHODS: Each @entity0 was genotyped for the SNPs @entity5 and @entity6 in the @entity2 gene. MAIN OUTCOMES MEASURES: Mean change in VA from baseline to 1 year after initiation of treatment with ranibizumab or bevacizumab. Differences in VA response between the @entity0 group homozygous for the minor allele of each SNP and the other genotype groups were evaluated with analysis of variance. Differences in VA response by the number of minor alleles present for either SNP or both combined were evaluated with tests of linear trend. Analyses were conducted separately for CATT and IVAN @entity0 and with both the studies combined. RESULTS: No statistically significant difference in mean change in VA was identified between genotypes of either SNP (P >=  0.05). Furthermore, a stepwise analysis failed to show a significant interaction for either SNP based on the number of minor alleles present. The lack of association was similar in both the CATT and IVAN cohorts and whether the analysis combined @entity0 treated with either ranibizumab or bevacizumab or when restricted to @entity0 treated with ranibizumab only. CONCLUSIONS: The CATT and IVAN data do not support a pharmacogenetic association between the 2  @entity2 SNPs, @entity5 and @entity6 , and change in VA in response to anti- @entity1 therapy in @entity0 with @entity3 .

title: XXXX Gene Polymorphisms and Response to Anti- @entity1 Therapy in Age-Related @entity3 .

answer: @entity2


abstract: PURPOSE: A previously published study demonstrated a pharmacogenetic association between the minor alleles of 2 @entity2 single nucleotide polymorphisms (SNPs) and greater improvement in visual acuity (VA) to treatment with ranibizumab, an @entity1 ( @entity1 ) drug, in @entity0 with neovascular @entity3 ( @entity3 ). We evaluated whether this association was replicated among @entity0 who participated in the Comparison of @entity3 Treatments Trials (CATT) or the Alternative Treatments to Inhibit @entity1 in @entity0 with Age-Related @entity4 (IVAN) trial. DESIGN: Cohort studies within randomized clinical trials. @entity0 : Eight hundred thirty-five @entity0 participating in CATT and 512 @entity0 participating in IVAN. METHODS: Each @entity0 was genotyped for the SNPs @entity5 and @entity6 in the @entity2 gene. MAIN OUTCOMES MEASURES: Mean change in VA from baseline to 1 year after initiation of treatment with ranibizumab or bevacizumab. Differences in VA response between the @entity0 group homozygous for the minor allele of each SNP and the other genotype groups were evaluated with analysis of variance. Differences in VA response by the number of minor alleles present for either SNP or both combined were evaluated with tests of linear trend. Analyses were conducted separately for CATT and IVAN @entity0 and with both the studies combined. RESULTS: No statistically significant difference in mean change in VA was identified between genotypes of either SNP (P >=  0.05). Furthermore, a stepwise analysis failed to show a significant interaction for either SNP based on the number of minor alleles present. The lack of association was similar in both the CATT and IVAN cohorts and whether the analysis combined @entity0 treated with either ranibizumab or bevacizumab or when restricted to @entity0 treated with ranibizumab only. CONCLUSIONS: The CATT and IVAN data do not support a pharmacogenetic association between the 2  @entity2 SNPs, @entity5 and @entity6 , and change in VA in response to anti- @entity1 therapy in @entity0 with @entity3 .

title: @entity2 Gene Polymorphisms and Response to Anti- @entity1 Therapy in Age-Related XXXX .

answer: @entity3


abstract: UNASSIGNED: @entity3 ( @entity3 ) goes into effect this year and it links the quality of care to payments for care. Starting in fiscal year 2013, the Centers for Medicare and Medicaid Services reduces all inpatient prospective payment system reimbursements by 1%. This money then can be returned to hospitals in the form of a bonus through @entity3 . @entity3 holds hospitals accountable for both cost and quality. With @entity3 , hospitals get a score that is based on the process of care, the outcomes, and @entity0 -centeredness. This means that reimbursements in health care, which keep hospitals in business, are transitioning from "volume of services" to @entity3 . Although @entity3 sounds like a great idea, particularly to politicians in Washington tasked with managing out-of-control health care expenditures, there is very little high-quality evidence that @entity3 will actually improve care. Nevertheless, this is the way we are going to be moving forward. The perception of @entity1 is a highly personalized phenomenon, and @entity2 affects every aspect of a @entity0 's life. The biopsychosocial model and the concept of utilizing an interdisciplinary team approach in the management of @entity2 make sense, but there are concerns that it could result in higher overall costs and no measurable improvements in the @entity0 's perception of care. Both results. could have a negative impact on @entity1 specialists.

title: New care measures and their impact on XXXX medicine: One @entity1 specialist's perspective.

answer: @entity1


abstract: UNASSIGNED: @entity3 ( @entity3 ) goes into effect this year and it links the quality of care to payments for care. Starting in fiscal year 2013, the Centers for Medicare and Medicaid Services reduces all inpatient prospective payment system reimbursements by 1%. This money then can be returned to hospitals in the form of a bonus through @entity3 . @entity3 holds hospitals accountable for both cost and quality. With @entity3 , hospitals get a score that is based on the process of care, the outcomes, and @entity0 -centeredness. This means that reimbursements in health care, which keep hospitals in business, are transitioning from "volume of services" to @entity3 . Although @entity3 sounds like a great idea, particularly to politicians in Washington tasked with managing out-of-control health care expenditures, there is very little high-quality evidence that @entity3 will actually improve care. Nevertheless, this is the way we are going to be moving forward. The perception of @entity1 is a highly personalized phenomenon, and @entity2 affects every aspect of a @entity0 's life. The biopsychosocial model and the concept of utilizing an interdisciplinary team approach in the management of @entity2 make sense, but there are concerns that it could result in higher overall costs and no measurable improvements in the @entity0 's perception of care. Both results. could have a negative impact on @entity1 specialists.

title: New care measures and their impact on @entity1 medicine: One XXXX specialist's perspective.

answer: @entity1


abstract: STUDY OBJECTIVE: To measure @entity1 victims' self rated health (SRH) status and SRH transition, and to compare how the two are prospectively associated with disability and recurrence free survival. DESIGN: Prospective case registry study with face to face follow up interviews at three months, one, two, and three years. Ascertained were SRH status and SRH transition using single question assessments, Barthel Index (BI), Frenchay Activities Index (FAI), and Mini Mental State Examination (MMSE). SETTING: A multiethnic inner city population of 234 533. @entity0 : @entity0 surviving the initial three months after a first in a lifetime @entity1 in 1995 to 1998. RESULTS: Of 690 @entity1 survivors 561 (81.3%) could complete the self report items. Answers to the item on SRH status did not vary significantly between the four follow up interviews. However, responses to the item on SRH transition changed significantly during follow up with three months ratings being more negative than all subsequent ratings. SRH transition, but not SRH status, showed a prospective association with long term outcome in multivariate analyses controlling for the BI, FAI, and MMSE. Compared with all other @entity0 , @entity0 reporting "Much worse health" at three months were more likely to be disabled ( = BI<20) at one year (OR 6.29, 95% CI 2.26 to 17.52) and their combined risk of @entity1 recurrence and @entity2 was increased over five years (HR 1.72, 95% CI 1.25 to 2.38). CONCLUSIONS: Items on SRH should be used with caution in populations with high rates of disability and language problems, as many @entity0 are unable to complete them. SRH transition may be a better predictor of disability and recurrence free survival after major medical events than SRH status.

title: Self ratings of health predict functional outcome and recurrence free survival after XXXX .

answer: @entity1


abstract: @entity1 is associated with insulin resistance. Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the @entity6 ) which is a strong risk factor for development of @entity2 2 @entity0 and CHD. The present article discusses how accumulation of @entity4 in adipocytes can lead to deterioration of the responsiveness of @entity3 metabolism in other tissues. @entity7 , lack of adipose tissue, is also associated with insulin resistance. Any plausible explanation for the link between excess adipose tissue and insulin resistance needs to be able to account for this observation. Adipose tissue in @entity1 becomes refractory to suppression of fat mobilization by insulin, and also to the normal acute stimulatory effect of insulin on activation of lipoprotein lipase (involved in fat storage). The net effect is as though adipocytes are 'full up' and resisting further fat storage. Thus, in the postprandial period especially, there is an excess flux of circulating lipid metabolites that would normally have been 'absorbed' by adipose tissue. This situation leads to fat deposition in other tissues. Accumulation of @entity4 in skeletal muscles and in liver is associated with insulin resistance. In @entity7 there is insufficient adipose tissue to absorb the postprandial influx of @entity5 , so these @entity5 will again be directed to other tissues. This view of the link between adipose tissue and insulin resistance emphasises the important role of adipose tissue in 'buffering' the daily influx of dietary fat entering the circulation and preventing excessive exposure of other tissues to this influx.

title: Adipose tissue and the XXXX .

answer: @entity6


abstract: Osteogenic properties of bone cells are a key parameter governing osseointegration of implant devices. In this context, osteoblasts have a central role via extracellular matrix synthesis and remodeling that they regulate through different protease activity. In this study, we have analyzed the expression of two matrix metalloproteinases (MMPs): @entity3 (72 kDa) and @entity4 (92 kDa) and their specific tissue inhibitors @entity6 and @entity5 in primary @entity0 osteoblastic cells. The effect of @entity2 , @entity9 , and @entity8 ceramics on the synthesis of these proteases was assessed using reverse transcriptase-polymerase chain reaction, enzyme-linked immunosorbent assay, and zymographic analysis. Our results showed that osteoblasts express @entity7 mRNA. Furthermore, @entity3 mRNA expression was decreased by @entity2 and increased by @entity8 whereas @entity9 did not have any significant effect. Conversely, @entity4 mRNA expression was stimulated by @entity2 but decreased with @entity9 , whereas @entity8 induced no significant changes. Zymographic analysis has evidenced pro- @entity3 gelatinolytic activity in all cell populations with time-dependent increase profile; pro- @entity4 , however, was not detected. Enzyme-linked immunosorbent assay data confirmed the production of @entity3 and very low levels of @entity4 . In addition, @entity6 was secreted in 24-h-cultured cells and increased to maximal level at 48-72 h whereas @entity5 levels were very low. The interactions between @entity0 osteoblasts and the studied biomaterials altered both @entity7 and @entity6 expression indicating that biomaterials may influence @entity1 .

title: Matrix metalloproteinases @entity7 and tissue inhibitors TIMP-1, -2 expression and secretion by primary @entity0 osteoblast cells in response to @entity2 , XXXX , and @entity8 ceramics.

answer: @entity9


abstract: Osteogenic properties of bone cells are a key parameter governing osseointegration of implant devices. In this context, osteoblasts have a central role via extracellular matrix synthesis and remodeling that they regulate through different protease activity. In this study, we have analyzed the expression of two matrix metalloproteinases (MMPs): @entity3 (72 kDa) and @entity4 (92 kDa) and their specific tissue inhibitors @entity6 and @entity5 in primary @entity0 osteoblastic cells. The effect of @entity2 , @entity9 , and @entity8 ceramics on the synthesis of these proteases was assessed using reverse transcriptase-polymerase chain reaction, enzyme-linked immunosorbent assay, and zymographic analysis. Our results showed that osteoblasts express @entity7 mRNA. Furthermore, @entity3 mRNA expression was decreased by @entity2 and increased by @entity8 whereas @entity9 did not have any significant effect. Conversely, @entity4 mRNA expression was stimulated by @entity2 but decreased with @entity9 , whereas @entity8 induced no significant changes. Zymographic analysis has evidenced pro- @entity3 gelatinolytic activity in all cell populations with time-dependent increase profile; pro- @entity4 , however, was not detected. Enzyme-linked immunosorbent assay data confirmed the production of @entity3 and very low levels of @entity4 . In addition, @entity6 was secreted in 24-h-cultured cells and increased to maximal level at 48-72 h whereas @entity5 levels were very low. The interactions between @entity0 osteoblasts and the studied biomaterials altered both @entity7 and @entity6 expression indicating that biomaterials may influence @entity1 .

title: Matrix metalloproteinases @entity7 and tissue inhibitors TIMP-1, -2 expression and secretion by primary @entity0 osteoblast cells in response to XXXX , @entity9 , and @entity8 ceramics.

answer: @entity2


abstract: Osteogenic properties of bone cells are a key parameter governing osseointegration of implant devices. In this context, osteoblasts have a central role via extracellular matrix synthesis and remodeling that they regulate through different protease activity. In this study, we have analyzed the expression of two matrix metalloproteinases (MMPs): @entity3 (72 kDa) and @entity4 (92 kDa) and their specific tissue inhibitors @entity6 and @entity5 in primary @entity0 osteoblastic cells. The effect of @entity2 , @entity9 , and @entity8 ceramics on the synthesis of these proteases was assessed using reverse transcriptase-polymerase chain reaction, enzyme-linked immunosorbent assay, and zymographic analysis. Our results showed that osteoblasts express @entity7 mRNA. Furthermore, @entity3 mRNA expression was decreased by @entity2 and increased by @entity8 whereas @entity9 did not have any significant effect. Conversely, @entity4 mRNA expression was stimulated by @entity2 but decreased with @entity9 , whereas @entity8 induced no significant changes. Zymographic analysis has evidenced pro- @entity3 gelatinolytic activity in all cell populations with time-dependent increase profile; pro- @entity4 , however, was not detected. Enzyme-linked immunosorbent assay data confirmed the production of @entity3 and very low levels of @entity4 . In addition, @entity6 was secreted in 24-h-cultured cells and increased to maximal level at 48-72 h whereas @entity5 levels were very low. The interactions between @entity0 osteoblasts and the studied biomaterials altered both @entity7 and @entity6 expression indicating that biomaterials may influence @entity1 .

title: Matrix metalloproteinases XXXX and tissue inhibitors TIMP-1, -2 expression and secretion by primary @entity0 osteoblast cells in response to @entity2 , @entity9 , and @entity8 ceramics.

answer: @entity7


abstract: Osteogenic properties of bone cells are a key parameter governing osseointegration of implant devices. In this context, osteoblasts have a central role via extracellular matrix synthesis and remodeling that they regulate through different protease activity. In this study, we have analyzed the expression of two matrix metalloproteinases (MMPs): @entity3 (72 kDa) and @entity4 (92 kDa) and their specific tissue inhibitors @entity6 and @entity5 in primary @entity0 osteoblastic cells. The effect of @entity2 , @entity9 , and @entity8 ceramics on the synthesis of these proteases was assessed using reverse transcriptase-polymerase chain reaction, enzyme-linked immunosorbent assay, and zymographic analysis. Our results showed that osteoblasts express @entity7 mRNA. Furthermore, @entity3 mRNA expression was decreased by @entity2 and increased by @entity8 whereas @entity9 did not have any significant effect. Conversely, @entity4 mRNA expression was stimulated by @entity2 but decreased with @entity9 , whereas @entity8 induced no significant changes. Zymographic analysis has evidenced pro- @entity3 gelatinolytic activity in all cell populations with time-dependent increase profile; pro- @entity4 , however, was not detected. Enzyme-linked immunosorbent assay data confirmed the production of @entity3 and very low levels of @entity4 . In addition, @entity6 was secreted in 24-h-cultured cells and increased to maximal level at 48-72 h whereas @entity5 levels were very low. The interactions between @entity0 osteoblasts and the studied biomaterials altered both @entity7 and @entity6 expression indicating that biomaterials may influence @entity1 .

title: Matrix metalloproteinases @entity7 and tissue inhibitors TIMP-1, -2 expression and secretion by primary @entity0 osteoblast cells in response to @entity2 , @entity9 , and XXXX ceramics.

answer: @entity8


abstract: Osteogenic properties of bone cells are a key parameter governing osseointegration of implant devices. In this context, osteoblasts have a central role via extracellular matrix synthesis and remodeling that they regulate through different protease activity. In this study, we have analyzed the expression of two matrix metalloproteinases (MMPs): @entity3 (72 kDa) and @entity4 (92 kDa) and their specific tissue inhibitors @entity6 and @entity5 in primary @entity0 osteoblastic cells. The effect of @entity2 , @entity9 , and @entity8 ceramics on the synthesis of these proteases was assessed using reverse transcriptase-polymerase chain reaction, enzyme-linked immunosorbent assay, and zymographic analysis. Our results showed that osteoblasts express @entity7 mRNA. Furthermore, @entity3 mRNA expression was decreased by @entity2 and increased by @entity8 whereas @entity9 did not have any significant effect. Conversely, @entity4 mRNA expression was stimulated by @entity2 but decreased with @entity9 , whereas @entity8 induced no significant changes. Zymographic analysis has evidenced pro- @entity3 gelatinolytic activity in all cell populations with time-dependent increase profile; pro- @entity4 , however, was not detected. Enzyme-linked immunosorbent assay data confirmed the production of @entity3 and very low levels of @entity4 . In addition, @entity6 was secreted in 24-h-cultured cells and increased to maximal level at 48-72 h whereas @entity5 levels were very low. The interactions between @entity0 osteoblasts and the studied biomaterials altered both @entity7 and @entity6 expression indicating that biomaterials may influence @entity1 .

title: Matrix metalloproteinases @entity7 and tissue inhibitors TIMP-1, -2 expression and secretion by primary XXXX osteoblast cells in response to @entity2 , @entity9 , and @entity8 ceramics.

answer: @entity0


abstract: PURPOSE: The purpose of this study was to evaluate the performance of @entity3 and MRI in @entity0 with @entity2 . MATERIALS AND METHODS: In this study, @entity0 with suspected @entity2 were evaluated by abdominal CT and MRI. This study included 32 @entity0 . In 23 cases, transurethral resection (TUR), and in 9 cases radical cystectomy was performed. Additionally, pelvic lymph node dissection was performed in 9 @entity0 . RESULTS: According to the pathological results of TUR-performed @entity0 ; the accuracy of @entity3 and MRI in preoperative staging of @entity2 was 41.6% and 83.3%, respectively. The accuracy of @entity3 and MRI in preoperative staging of @entity2 were 66.6% and 77.7% in @entity0 who underwent radical cystectomy. Pelvic lymph node involvement was evaluated properly with MRI and CT. CONCLUSION: In the preoperative staging of @entity2 , MRI is superior to CT. The superiority is more definite especially in early stage @entity1 .

title: [Staging of XXXX with CT and MRI].

answer: @entity2


abstract: UNASSIGNED: In the new @entity0 EndoC-bH1 b-cell line, a detailed analysis of the physiological characteristics was performed. This new @entity0 b-cell line expressed all target structures on the gene and protein level, which are crucial for physiological function and insulin secretion induced by @entity5 and other secretagogues. @entity5 influx measurements revealed an excellent uptake capacity of EndoC-bH1 b-cells by the @entity9 and @entity19 @entity5 transporters. A high expression level of @entity17 enabled efficient @entity5 phosphorylation, increasing the @entity6 / @entity7 ratio along with stimulation of insulin secretion in the physiological @entity5 concentration range. The EC50 value of @entity5 for insulin secretion was 10.2 mM. Mannoheptulose, a specific @entity17 inhibitor, blocked @entity5 -induced insulin secretion (GSIS).The nutrient insulin secretagogues @entity12 and @entity14 also stimulated insulin secretion, with a potentiating effect of @entity15 . The @entity18 @entity8 channel blocker @entity13 and @entity16 , an opener of the voltage-sensitive @entity3 channel significantly potentiated GSIS. Potentiation of GSIS by @entity10 and @entity11 went along with a strong stimulation of @entity4 generation. In conclusion, the new @entity0 EndoC-bH1 b-cell line fully mirrors the analogous physiological characteristics of primary @entity1 , @entity2 and @entity0 b-cells. Thus, this new @entity0 EndoC-bH1 b-cell line is very well suited for physiological b-cell studies.

title: Physiological characterization of the XXXX EndoC-bH1 b-cell line.

answer: @entity0


abstract: INTRODUCTION: The @entity8 of the foundry workers using chipping hammers and grinders were analysed in Hungary last in 1950th-s years. Therefore it seemed necessary to consider the present situation of the disease. AIM: To study of the signs of the @entity8 of the foundry workers using chipping hammers and grinders. METHOD: Retrospective analysis of the clinical findings of 154 foundry workers using chipping hammers and grinders. The examination included the vascular, neurological and musculoskeletal systems of the upper extremities in 95 @entity0 . RESULTS: The first symptoms referring to @entity8 appeared on the average after seven years exposure. The signs of the 95 @entity0 were as follows: @entity4 : 75 cases (78.9%), peripheral @entity1 : 62 cases (65.3%), @entity1 : 35 @entity0 (36.8%). The Raynaud's phenomenon developed more commonly on the left than the right hand. The rate of the improvement of the Raynaud's phenomenon on the average 6.5 years after the cessation of the exposure on the basis of the result of the cold provocation test was 32.8%. Lesion of the peripheral nerves of the upper limbs, mostly of distal type was experienced in 41, whereas tunnel syndromes of the upper extremities in 21 cases. The most common amongst the latter (18 cases) was the @entity5 . @entity3 of the carpal bones was detected in 36 @entity0 (37.9%), but @entity6 of the joints of the upper limbs in 12 cases (12.6%). There was no aseptic @entity2 of the bones. @entity7 of the spinous process of the cervical VII vertebra occurred in one single case. CONCLUSIONS: Using chipping hammers and grinders in foundry is one of the most dangerous hand-arm vibration exposure in Hungary. The most frequent signs are the vascular and @entity1 . Due to relatively rare occurrence of @entity1 X-ray examinations are not necessary during periodical medical follow up. The most effective possibility of the prevention is the diminishing of the daily exposure time.

title: [ XXXX in foundry workers].

answer: @entity8


abstract: BACKGROUND: In acute posterior cerebral artery, occlusion involvement of the hippocampus is a common finding. Nevertheless, until today, @entity2 and @entity3 evolution in the hippocampus has not been studied systematically. AIM: Evaluation of @entity4 patterns in @entity1 in the very early phase ( <=six-hours) and @entity3 evolution on follow-up magnetic resonance imaging in relation to collateral blood flow assessed by a magnetic resonance imaging-based approach was conducted. METHODS: In 28 @entity0 [mean age 69  4        13  8 years, 19 (67  9%) males, 10 (32  1%) females] with proximal @entity1 , magnetic resonance imaging findings were analyzed, with emphasis on @entity4 patterns on diffusion-weighted images and collateralization on dynamic 4D angiograms derived from perfusion-weighted raw images. RESULTS: On initial diffusion-weighted images, we identified all known @entity4 patterns: type 1 (complete) in 6/18 (33  3%) @entity0 , type 2 (lateral) in 10/18 (55  6%) @entity0 , and type 3 (dorsal) and type 4 (circumscribed) in 1/18 (5  6%) @entity0 respectively. On dynamic 4D angiograms, the grade of collateralization was classified as 1 in 9 (32  1%), 2 in 1 (3  6%), 3 in 10 (35  7%), and 4 in 8 (28  6%) @entity0 . On follow-up diffusion-weighted images, we found new @entity3 in three and @entity2 growth in the hippocampus in five @entity0 . @entity0 with better collateralization (grades 3 and 4) less often had hippocampal @entity2 on initial (P   =   0  003)/follow-up diffusion-weighted images (P   =   0  046) as well as type 1 on initial (P   =   0  007)/follow-up diffusion-weighted images (P   =   0  005). CONCLUSIONS: Involvement of the hippocampus in proximal @entity1 is frequently but not obligatorily observed and highly dependent on the extent of collateralization. The same holds true for @entity4 patterns.

title: Sparing of the hippocampus indicates better collateral blood flow in XXXX .

answer: @entity1


abstract: PURPOSE: To evaluate the safety and recanalization efficacy of local IA rt-PA delivery in @entity0 with acute @entity3 . MATERIALS AND METHODS: Fifteen @entity0 with acute @entity3 were treated; of these, 10 were carotid @entity2 , 5 were vertebrobasilar territory @entity2 cases. The neurological status of the @entity0 were graded according to the Glascow @entity7 Scale and National Institutes of @entity2 Scale. All @entity0 underwent a CT examination on admission. In addition, 4 @entity0 had diffusion-weighted and one @entity0 had a perfusion MR examination. @entity0 of carotid territory @entity2 were treated within 6 hours from the @entity2 onset. There was no time limitation for the basilar artery territory. The Rankin Scale (RS) was used as outcome measures. RESULTS: Two of the 10 @entity0 with carotid @entity2 had carotid territory occlusions, 8 had middle cerebral artery main trunk occlusions. Four @entity0 had symptomatic @entity5 ; of these, 3 died within 24 hours. At the third month 4 @entity0 had a good outcome. Of 5 @entity0 with basilar @entity2 , 4 had basilar @entity4 . In one @entity0 , the basilar artery was open but the flow of the contrast material was very slow. Two @entity0 with unsuccessful recanalization due to underlying high grade @entity6 and one @entity0 with successful recanalization died. At the third month, the other @entity0 with succesful recanalization had a poor outcome (RS 4). The @entity0 with slow basilar artery flow developed from RS 5 to @entity8 and was discharged without any @entity1 . CONCLUSION: In acute @entity3 , local IA thrombolysis is a safe and feasible treatment when the right @entity0 is selected. @entity5 does not exceed that which occurs in the natural history of the disease and with other treatment methods.

title: [Intraarterial thrombolysis in the treatment of acute XXXX : Technical and clinical results].

answer: @entity3


abstract: Between January 1997 and April 2002, 73 consecutive invasive strains of @entity4 were isolated from @entity0 under 16 years of age in four hospitals in suburban Paris. Their genetic diversity was investigated by serotyping and analysis of pulsed-field gel electrophoresis restriction patterns. Antibiotic susceptibility patterns were analysed by disk susceptibility testing and determination of minimal inhibitory concentrations. The genetic basis of @entity10 resistance was investigated by polymerase chain reaction. Studies of @entity2 and @entity5 tolerance were performed for each strain. Despite the high prevalence (45.2%) of @entity2 -nonsusceptible @entity4 , resistance to @entity3 (1.4%) was rare, and no strain was resistant to @entity9 . Overall, 4.1% of pneumococcal strains were resistant to @entity2 . @entity2 or @entity5 tolerance was not detected in any of the 73 strains studied. Of the @entity8 -resistant strains (48%), all but one carried the ermB gene. No strains showing a decreased susceptibility to @entity6 ( @entity11 , >4 mg/l) or overexpressing an efflux pump inhibited by @entity7 were isolated. The serotypes found, in order of frequency, were as follows: 18C, 14, 6B, 19F, 19A, 9V, 23F, 1, 7F, 9A, 38. Strains of @entity2 -nonsusceptible @entity4 belonged predominantly to serotypes 14, 6B, 9V, 9A, 23F, 19F and 19A. The seven-valent conjugated vaccine covered 85.5% of the serogroups isolated in @entity0 under 2 years of age and 65.6% of the serogroups identified in @entity0 over 2 years of age. The genetic analysis showed a high identity for some serotypes, such as 14/9V, 6B and 23F. The use of the seven-valent conjugated vaccine is a critical measure to prevent @entity1 in @entity0 in the Ille de France area.

title: Multicentre study of the molecular epidemiology, serotypes and antimicrobial susceptibility patterns of invasive XXXX invasive isolated from @entity0 in the Ille de France area.

answer: @entity4


abstract: Between January 1997 and April 2002, 73 consecutive invasive strains of @entity4 were isolated from @entity0 under 16 years of age in four hospitals in suburban Paris. Their genetic diversity was investigated by serotyping and analysis of pulsed-field gel electrophoresis restriction patterns. Antibiotic susceptibility patterns were analysed by disk susceptibility testing and determination of minimal inhibitory concentrations. The genetic basis of @entity10 resistance was investigated by polymerase chain reaction. Studies of @entity2 and @entity5 tolerance were performed for each strain. Despite the high prevalence (45.2%) of @entity2 -nonsusceptible @entity4 , resistance to @entity3 (1.4%) was rare, and no strain was resistant to @entity9 . Overall, 4.1% of pneumococcal strains were resistant to @entity2 . @entity2 or @entity5 tolerance was not detected in any of the 73 strains studied. Of the @entity8 -resistant strains (48%), all but one carried the ermB gene. No strains showing a decreased susceptibility to @entity6 ( @entity11 , >4 mg/l) or overexpressing an efflux pump inhibited by @entity7 were isolated. The serotypes found, in order of frequency, were as follows: 18C, 14, 6B, 19F, 19A, 9V, 23F, 1, 7F, 9A, 38. Strains of @entity2 -nonsusceptible @entity4 belonged predominantly to serotypes 14, 6B, 9V, 9A, 23F, 19F and 19A. The seven-valent conjugated vaccine covered 85.5% of the serogroups isolated in @entity0 under 2 years of age and 65.6% of the serogroups identified in @entity0 over 2 years of age. The genetic analysis showed a high identity for some serotypes, such as 14/9V, 6B and 23F. The use of the seven-valent conjugated vaccine is a critical measure to prevent @entity1 in @entity0 in the Ille de France area.

title: Multicentre study of the molecular epidemiology, serotypes and antimicrobial susceptibility patterns of invasive @entity4 invasive isolated from XXXX in the Ille de France area.

answer: @entity0


abstract: The course and outcome of @entity0 after liver transplantation (LT) for @entity9 ( @entity9 ) are still debated. Our purpose is to define retrospectively, the post-LT clinicopathologic findings seen in 51 @entity9 @entity0 with a follow-up of 2 to 14 years. Of the total 51 @entity0 , 16 with native liver @entity10 (XGC) had median graft and @entity0 survival of 573 and 835 days, respectively compared with 2489 and 2794 days, respectively, in 35 @entity0 without XGC. Perioperative complications resulted in 9 early @entity4 (day 0 to 52). Of the remaining 42 @entity0 , 6 had recurrent @entity9 (R- @entity9 ) with typical histologic and cholangiographic findings, 12 had @entity6 -not otherwise specified with histology of @entity7 , 3 had chronic rejection, 4 had @entity3 , and 17 had no recurrence. The presence of @entity2 , total @entity3 time of > or =11 hours, recipient-donor ABO and HLA Class I and II matches, and the type of immunosuppression did not affect the post-LT outcome. Recipient-donor gender mismatch was more common in R- @entity9 than in the nonrecurrent group (P=0.045). Post-LT @entity1 were significantly more common in the nonrecurrent cases compared with all others combined (P=0.031) and caused @entity4 in 4. The majority of @entity4 (11/13) in other groups were due to @entity5 complicating @entity8 . In conclusion, allograft @entity6 was seen in 18 (43%) of 42 long-term post-LT @entity9 @entity0 , with progression in 5 of 18 @entity0 . Features of @entity9 were seen in 6 (33%) of 18. Native liver XGC negatively impacted post-LT graft and @entity0 survival. Increased incidence of @entity1 in the nonrecurrent group may reflect overimmunosuppression in those @entity0 .

title: Liver transplantation for XXXX : a long-term clinicopathologic study.

answer: @entity9


abstract: OBJECTIVE: Exercise advice is the main treatment for symptom relief in the UK for @entity0 with mild to moderate @entity1 ( @entity1 ). Would a weekly exercise and motivation class for 6 months offer adjuvant benefit over written and verbal exercise advice alone? @entity0 AND METHODS: Fifty-nine @entity0 attending a regional vascular centre for whom @entity1 was the main factor affecting mobility were randomised to either exercise advice alone (n=30) or exercise advice with a once a week 45 min supervised exercise/motivation class (n=29). The mean age was 68 years. Baseline and 6-month assessment included a Quality of Life Questionnaire--the Short-Form-36, the Charing Cross Symptom Specific Claudication Questionnaire (CCCQ) and treadmill walking distance (3.5 km/h 12%). RESULTS: At 6-month follow-up the supervised exercise group had improved their treadmill walking by 129% compared to 69% in the advice alone group (p=0.001). This significant improvement was maintained at the subsequent 9 and 12-month follow-up assessments. By the 9-month stage the advice only group CCCQ score had improved 16% from baseline, while the supervised exercise group had a significantly better 43% improvement in base line score (p<0.05). Self reported frequency of walks was higher in the exercise class group being significant for improvement in CCCQ score. CONCLUSION: A weekly, supervised exercise and motivation class for a 6-month period provides a significant improvement in @entity0 ' symptoms, quality of life, and distance walked compared with advice alone and this improvement continues after attendance at class has ceased.

title: Does supervised exercise offer adjuvant benefit over exercise advice alone for the treatment of XXXX ? A randomised trial.

answer: @entity1


abstract: @entity4 are common after hematopoietic stem cell transplantation (HSCT). Although the pathology of chronic @entity1 is well described, the histologic changes that accompany acute @entity1 after HSCT are less well known because renal biopsies are rarely undertaken in the peritransplantation period. Archival renal tissue from consecutive HSCT recipients who died and underwent autopsy at a single center during an 8-year period was studied. Abnormalities of renal pathology were described, and associations of histologic abnormalities with clinical events were systemically studied. Abnormalities of renal histology were common among the 26 @entity0 in this study. The 3 most common histologic abnormalities were @entity1 (19/26; 73%), tubular epithelial atypia (19/26; 73%), and tubular calcification (18/26; 69%). @entity7 (16/24; 67%) and @entity2 (16/26; 62%) were also frequently observed. Clinical @entity6 was not associated with histologic evidence of @entity8 in the kidney at autopsy. Also, clinical @entity5 was not associated with @entity1 . Unexpectedly, the proportion of @entity0 with tubular @entity3 (54%) or @entity2 (62%) was high, considering the young age of the @entity0 at transplantation and their normal pretransplantation creatinine clearance. Well-recognized histologic abnormalities are common in the kidneys of @entity0 who die after HSCT. Although we did not demonstrate associations of these histologic changes with clinical variables before death, larger studies with prospectively collected renal tissue are warranted.

title: Renal pathology at autopsy in XXXX who died after hematopoietic stem cell transplantation.

answer: @entity0


abstract: Better biomarkers that can discriminate between @entity3 and indolent phenotypes of @entity4 are urgently needed. In the first 20 years of the prostate-specific antigen (PSA) era, screening for @entity4 has successfully reduced @entity4 mortality, but has led to significant problems with overdiagnosis and overtreatment. As a result, many @entity0 are subjected to unnecessary prostate biopsies and overtreatment of indolent @entity2 in order to save one @entity0 from dying of @entity4 . A novel blood test known as the 4Kscore   Test (OPKO Lab, Nashville, @entity5 ) incorporates a panel of four kallikrein protein biomarkers (total PSA, free PSA, intact PSA, and @entity0 @entity6 ) and other clinical information in an algorithm that provides a percent risk for a high-grade (Gleason score >=  7) @entity2 on biopsy. In 10 peer-reviewed publications, the four kallikrein biomarkers and algorithm of the 4Kscore Test have been shown to improve the prediction not only of biopsy histopathology, but also surgical pathology and occurrence of @entity3 , @entity1 . Recently, a blinded prospective trial of the 4Kscore Test was conducted across the United States among 1012 @entity0 . The 4Kscore Test replicated previous European results showing accuracy in predicting biopsy outcome of Gleason score >=  7. In a recent case-control study nested within a population-based cohort from V  sterbotten, Sweden, the four kallikrein biomarkers of the 4Kscore Test also predicted the risk for @entity4 that metastasized within 20 years after the test was administered. These results indicate that @entity0 with an abnormal PSA or digital rectal examination result, and for whom an initial or repeat prostate biopsy is being considered, would benefit from a reflex 4Kscore Test to add important information to the clinical decision-making process. A high-risk 4Kscore Test result may be used to select @entity0 with a high probability of @entity4 who would benefit from a biopsy of the prostate to prevent an adverse and potentially lethal outcome from @entity4 . @entity0 with a low 4Kscore Test result may safely defer biopsy.

title: Finding the Wolf in Sheep's Clothing: The 4Kscore Is a Novel Blood Test That Can Accurately Identify the Risk of Aggressive XXXX .

answer: @entity4


abstract: PURPOSE: To determine the impact of @entity1 on time to successful renal artery cannulation and procedure efficiency during fenestrated and snorkel/chimney @entity3 repair (EVAR). METHODS: The imaging and procedure logs of 77 @entity0 (mean age 74.2 years; 63 @entity0 ) who underwent complex EVAR (24 fenestrated, 53 snorkel/chimney) from 2009 to 2013 were reviewed. Renal artery angulation was measured on preoperative computed tomographic angiography scans. Time to renal artery cannulation was retrieved from the EVAR procedure logs and compared to preoperative @entity1 and other metrics of procedure efficiency (eg, procedure time, fluoroscopy time, @entity2 , etc). In all, 111 renal arteries were available for @entity1 measurement (39 fenestrated, 72 snorkel/chimney); 22 renal cannulations were inappropriate for the comparative analyses due to concomitant visceral artery stenting (n=15), combined procedures (n=6), or unsuccessful cannulation (n=1). RESULTS: For @entity0 undergoing fenestrated EVAR, mean @entity1 was -28    21   (range +37   to -60  ), not significantly different (p=0.66) from @entity0 receiving snorkel/chimney grafts (mean -30    19  , range +22   to -65  ). Comparative analysis using median @entity1 (-30   for both groups) demonstrated that renal artery cannulation during fenestrated EVAR was performed significantly faster in arteries with less downward (>=  -30  ) angulation (16.0 vs 32.8 minutes, p=0.04), whereas cannulation in snorkel/chimneys was faster in arteries with greater downward (< -30  ) angulation (10.9 vs 17.3 minutes, p=0.05). Fenestrated EVAR cases involving less downward (>=  -30  ) @entity1 were also associated with shorter overall procedure time (187.7 vs 246.2 minutes, p=0.01) and decreased fluoroscopy time (70.3 vs 98.2 minutes, p=0.04). Immediate renal function decline, procedural complications, and postoperative issues were not associated with @entity1 . CONCLUSION: Procedural efficiency may be optimized by considering @entity1 as one of several objective variables used in the selection of an appropriate endovascular strategy. The fenestrated approach is more efficient with less downward angulation to the renal arteries, while the snorkel/chimney strategy is facilitated by more downward @entity1 .

title: Impact of Renal Artery Angulation on Procedure Efficiency During Fenestrated and Snorkel/Chimney XXXX Repair.

answer: @entity3


abstract: This chapter summarizes experiments which were designed to reveal how repetitive electrical stimulation of the @entity1 locomotor region (MLR) recruits nearby hindbrain neurons into activity, such that locomotion can ensue in the @entity2 salamander, A. tigrinum. The MLR stimulus strength was subthreshold or near-threshold for @entity0 to ensue. Such relatively weak stimulation of the MLR produced @entity0 after a relatively long delay, which featured neuronal interactions in the hindbrain. MLR-evoked spike responses of single hindbrain neurons were recorded before @entity0 began. This allowed consideration of the build-up of the hindbrain neuronal activity, which was subsequently impressed upon the spinal cord such as to evoke @entity0 . Each train of MLR stimulus pulses evoked monosynaptic responses in but a small proportion of the hindbrain's neurons. Rather, oligosynaptic responses were routinely evoked, even in the "input" neurons that were activated monosynaptically. Consecutive stimulus volleys recruited a given neuron after a variable number of synaptic translations. It is argued that the hindbrain's input neurons excited a much larger number of other hindbrain neurons. By this means, an MLR-evoked, short-lived propagating wave of excitation (i.e., approximately 2-4 successive synaptic activations) can be spread throughout the hindbrain.

title: How the XXXX locomotor region recruits hindbrain neurons.

answer: @entity1


abstract: BACKGROUND: Japan has introduced an acute @entity1 care unit to the public healthcare insurance program, but its requirement of a shorter length of stay could lead to discharges without proper discharge planning. The aim of this study was to examine the association between the implementation of discharge planning and the length of stay of acute @entity1 inpatients in Japan. METHODS: This retrospective cross-sectional study included 449 @entity0 discharged from the ' @entity1 emergency ward' of 66 hospitals during a two-week period from March 7 to 20, 2011. The assigned nurse or nursing assistant for each @entity0 provided information on the implementation of discharge planning in the hospital stay. RESULTS: Approximately one quarter of the 449 @entity0 (n  =  122) received no support for coordination with post-discharge community care resources. The 122 @entity0 who had received no support for community care coordination had a significantly lower mean age at admission, a shorter length of stay, and a higher rate of either no follow-up or unidentified post-discharge outpatient service than the other 327 @entity0 . Multilevel linear regression analysis demonstrated a significantly greater length of stay among @entity0 who were older, those who had a primary diagnosis of @entity2 , those who were admitted compulsorily, those who received hospital outpatient services, and those who received community care coordination support from the assigned nurse or nursing assistant. The implementation of support for community care coordination did not indicate a significant association with these factors, which have been related to an increased risk of @entity1 readmission. CONCLUSION: @entity0 to whom the assigned nurse or nursing assistant provided support on community care coordination experienced a significantly greater length of hospital stay. The implementation of support for community care coordination did not indicate a significant association with these factors, which have been related to an increased risk of @entity1 readmission. The mental health policy should increase focus on discharge planning in the acute @entity1 setting to enhance a link between @entity1 inpatient care and post-discharge community care resources.

title: Association between length of hospital stay and implementation of discharge planning in acute XXXX inpatients in Japan.

answer: @entity1


abstract: Traumatic self-amputation of the penis by a @entity5 @entity0 is rare. Microvascular replantation is the favored management approach. There are no known cases of self-amputation followed by @entity1 and subsequent replantation. A 51-year-old @entity0 with paranoid @entity2 presented 2 hours following @entity4 . He had swallowed the excised portion, which was endoscopically retrieved from the stomach in the emergency department. Successful reattachment was achieved including microvascular repair of the dorsal penile arteries without cavernosal arterial anastamoses. A Winter's shunt was performed to improve venous circulation. The @entity0 has been followed for 3 years from the date of repair. He has adequate erection for intercourse and good urinary function, but has experienced sensory loss over the dorsal aspect and glans and @entity3 . This is the first report of replantation following ingestion of an amputated penis.

title: XXXX and successful reattachment and the role of winter shunt in postoperative viability: A case report and literature review.

answer: @entity4


abstract: The AKR @entity3 is a T lymphocyte @entity1 , most suitable as a model for @entity0 T cell @entity1 . We have been interested in the process of @entity1 progression in the @entity3 system. In the present study, two newly isolated variants, the TAU-42 and TAU-44, were characterized with respect to their biological behavior, by comparing them to a previously studied low-malignancy variant, the TAU-39. While the TAU-44 variant formed large s.c. local @entity1 , the TAU-42 variant formed only small growths or none at all. The TAU-42 @entity3 was found to have the highest malignant potential: it displayed very marked dissemination to spleen, lymph nodes, liver and lungs. The TAU-44 variant had an intermediate degree of metastatic potential but presented a predilection for spread to lymph nodes and spleen and was sometimes found to metastasize to peculiar organs, such as heart and pancreas. Cells derived from the @entity3 variants varied in their immunophenotype: the highly malignant variant cells expressed more CD4 antigen than the low-malignancy one. The opposite was observed with regard to @entity2 . The variant cells also differed in their migrating capacity, the more malignant one exhibiting a higher motile activity. Studies on the @entity1 progression model of @entity3 might contribute to the elucidation of the features determining the aggressiveness of @entity4 .

title: Biological behavior and cell properties of new AKR XXXX variants.

answer: @entity3


abstract: @entity4 is one of the most frequent diseases in postmenopausal @entity1 , leading to an increased @entity6 risk due to the physiologic loss of the bone protective effects of @entity5 . Hereby, several risk factors for @entity6 such as prevalent @entity6 , low @entity3 ( @entity3 ), age, low body mass index, family history, tendency to falls, smoking, use of SSRIs, glucocorticoid use etc. have been identified. In addition, the further reduction in endogenous @entity5 with @entity9 ( @entity9 ), @entity8 analoga or aromatase inhibitors (AIs) continuously increases @entity6 risk. @entity0 ( @entity0 ) on the other hand is the most frequent @entity2 type in @entity1 . Recent reports indicate a continuous increased incidence, whereas mortality, due to early diagnosis and treatment improvements, is decreasing. @entity2 characteristics, radiation, @entity9 , antibody treatment as well as endocrine treatment have been included into the adjuvant clinical treatment setting. Some but not all of these @entity2 -specific treatments interfere with bone turnover, leading to an accelerated @entity7 referred to as @entity2 treatment-induced @entity7 (CTIBL). Whereas @entity9 leads to an unspecific increase in bone resorption, AI reduces residual serum endogenous @entity5 level and is associated with a decrease in @entity3 and increased @entity6 risk. Independent of the type of AI administered, @entity7 is 2-3-fold increased compared with healthy, age-matched postmenopausal controls. Therefore, several guidelines have emerged to help managing CTIBL in @entity1 with @entity0 including strategies to identify and treat those at highest risk for @entity6 . This review summarizes the current knowledge on CTIBL and fracturing risk and indicates preventative strategies.

title: Cancer Treatment-Induced XXXX in @entity1 with @entity0 .

answer: @entity7


abstract: @entity4 is one of the most frequent diseases in postmenopausal @entity1 , leading to an increased @entity6 risk due to the physiologic loss of the bone protective effects of @entity5 . Hereby, several risk factors for @entity6 such as prevalent @entity6 , low @entity3 ( @entity3 ), age, low body mass index, family history, tendency to falls, smoking, use of SSRIs, glucocorticoid use etc. have been identified. In addition, the further reduction in endogenous @entity5 with @entity9 ( @entity9 ), @entity8 analoga or aromatase inhibitors (AIs) continuously increases @entity6 risk. @entity0 ( @entity0 ) on the other hand is the most frequent @entity2 type in @entity1 . Recent reports indicate a continuous increased incidence, whereas mortality, due to early diagnosis and treatment improvements, is decreasing. @entity2 characteristics, radiation, @entity9 , antibody treatment as well as endocrine treatment have been included into the adjuvant clinical treatment setting. Some but not all of these @entity2 -specific treatments interfere with bone turnover, leading to an accelerated @entity7 referred to as @entity2 treatment-induced @entity7 (CTIBL). Whereas @entity9 leads to an unspecific increase in bone resorption, AI reduces residual serum endogenous @entity5 level and is associated with a decrease in @entity3 and increased @entity6 risk. Independent of the type of AI administered, @entity7 is 2-3-fold increased compared with healthy, age-matched postmenopausal controls. Therefore, several guidelines have emerged to help managing CTIBL in @entity1 with @entity0 including strategies to identify and treat those at highest risk for @entity6 . This review summarizes the current knowledge on CTIBL and fracturing risk and indicates preventative strategies.

title: Cancer Treatment-Induced @entity7 in @entity1 with XXXX .

answer: @entity0


abstract: @entity4 is one of the most frequent diseases in postmenopausal @entity1 , leading to an increased @entity6 risk due to the physiologic loss of the bone protective effects of @entity5 . Hereby, several risk factors for @entity6 such as prevalent @entity6 , low @entity3 ( @entity3 ), age, low body mass index, family history, tendency to falls, smoking, use of SSRIs, glucocorticoid use etc. have been identified. In addition, the further reduction in endogenous @entity5 with @entity9 ( @entity9 ), @entity8 analoga or aromatase inhibitors (AIs) continuously increases @entity6 risk. @entity0 ( @entity0 ) on the other hand is the most frequent @entity2 type in @entity1 . Recent reports indicate a continuous increased incidence, whereas mortality, due to early diagnosis and treatment improvements, is decreasing. @entity2 characteristics, radiation, @entity9 , antibody treatment as well as endocrine treatment have been included into the adjuvant clinical treatment setting. Some but not all of these @entity2 -specific treatments interfere with bone turnover, leading to an accelerated @entity7 referred to as @entity2 treatment-induced @entity7 (CTIBL). Whereas @entity9 leads to an unspecific increase in bone resorption, AI reduces residual serum endogenous @entity5 level and is associated with a decrease in @entity3 and increased @entity6 risk. Independent of the type of AI administered, @entity7 is 2-3-fold increased compared with healthy, age-matched postmenopausal controls. Therefore, several guidelines have emerged to help managing CTIBL in @entity1 with @entity0 including strategies to identify and treat those at highest risk for @entity6 . This review summarizes the current knowledge on CTIBL and fracturing risk and indicates preventative strategies.

title: Cancer Treatment-Induced @entity7 in XXXX with @entity0 .

answer: @entity1


abstract: BACKGROUND: Midgut @entity2 ( @entity2 ) @entity0 are often diagnosed at an advanced stage with extensive mesenteric lymph node and liver @entity1 . Even with skillful surgical dissection, macro and microscopic @entity3 at the dissection site remains a possibility. We hypothesize these potential @entity2 residuals in mesenteric lymph node dissection beds can be eliminated safely by a local application of @entity5 ( @entity5 ). We describe a novel technique invented by the author to treat these micro and macro residuals. METHODS: Retrospectively, charts of 62 consecutive midgut @entity2 @entity0 with boggy mesenteric @entity6 who underwent cytoreductive debulking surgeries from 1/2007 to 12/2009 were reviewed. A total of 32 @entity0 received an intraoperative application of @entity5 saturated gelfoam strips secured into the mesenteric defect following the extensive lymphadenectomy. A total of 30 untreated @entity0 served as a control. RESULTS: The 5-year survival after cytoreductive surgeries was 22/32 (68.8%) for the treated group, vs. 20/30 (66.7%) for the control. Six @entity0 (6/32, 18.8%) among the study group required additional debulking surgeries, vs. 16 @entity0 (16/30, 53.3%) in the control group. Upon reoperation, loco-regional recurrence was noted in 9 of the 16 @entity0 (56.3%) in the control group, vs. only 2/6 (33.3%) of treated @entity0 . Overall, local recurrence rate is 6.25% (2/32) in the treated group vs. 30% (9/30) in the control group. @entity4 rates are similar in the two arms. CONCLUSIONS: Intraoperative application of chemotherapy is a safe and effective adjuvant to reduce local recurrence and the need of reoperation by the tumoricidal or tumorstatic effects of @entity5 on any potential microscopic @entity3 after extensive cytoreductive surgeries in advanced stage @entity2 @entity0 with mesenteric lymph node @entity1 . It provides @entity0 with sustained, slow releasing, high dose of @entity5 within the surgical bed with a negligible side effect profile. Further studies are required to evaluate its effect on long term survival.

title: Adjuvant intraoperative post-dissectional @entity2 bed chemotherapy-A novel approach in treating midgut XXXX .

answer: @entity2


abstract: BACKGROUND: Midgut @entity2 ( @entity2 ) @entity0 are often diagnosed at an advanced stage with extensive mesenteric lymph node and liver @entity1 . Even with skillful surgical dissection, macro and microscopic @entity3 at the dissection site remains a possibility. We hypothesize these potential @entity2 residuals in mesenteric lymph node dissection beds can be eliminated safely by a local application of @entity5 ( @entity5 ). We describe a novel technique invented by the author to treat these micro and macro residuals. METHODS: Retrospectively, charts of 62 consecutive midgut @entity2 @entity0 with boggy mesenteric @entity6 who underwent cytoreductive debulking surgeries from 1/2007 to 12/2009 were reviewed. A total of 32 @entity0 received an intraoperative application of @entity5 saturated gelfoam strips secured into the mesenteric defect following the extensive lymphadenectomy. A total of 30 untreated @entity0 served as a control. RESULTS: The 5-year survival after cytoreductive surgeries was 22/32 (68.8%) for the treated group, vs. 20/30 (66.7%) for the control. Six @entity0 (6/32, 18.8%) among the study group required additional debulking surgeries, vs. 16 @entity0 (16/30, 53.3%) in the control group. Upon reoperation, loco-regional recurrence was noted in 9 of the 16 @entity0 (56.3%) in the control group, vs. only 2/6 (33.3%) of treated @entity0 . Overall, local recurrence rate is 6.25% (2/32) in the treated group vs. 30% (9/30) in the control group. @entity4 rates are similar in the two arms. CONCLUSIONS: Intraoperative application of chemotherapy is a safe and effective adjuvant to reduce local recurrence and the need of reoperation by the tumoricidal or tumorstatic effects of @entity5 on any potential microscopic @entity3 after extensive cytoreductive surgeries in advanced stage @entity2 @entity0 with mesenteric lymph node @entity1 . It provides @entity0 with sustained, slow releasing, high dose of @entity5 within the surgical bed with a negligible side effect profile. Further studies are required to evaluate its effect on long term survival.

title: Adjuvant intraoperative post-dissectional XXXX bed chemotherapy-A novel approach in treating midgut @entity2 .

answer: @entity2


abstract: BACKGROUND: Appropriate management of @entity1 remains controversial largely because outcomes data are lacking. It is our hypothesis that clinical factors, such as comorbidity, @entity2 , and timing of colonoscopy, are associated with hospital lengths of stay. METHODS: Medical records of @entity0 hospitalized for @entity1 from 1993 to 2000 were reviewed and abstracted, and a Cox regression model was constructed to explore associations between time to discharge (i.e., length of stay) and clinical parameters. RESULTS: A total of 565 hospitalizations for @entity1 were examined in which mean length of stay was 6.7 days. Colonoscopy was performed during 415 hospitalizations. Approximately a third of @entity0 were discharged within 48 hours after colonoscopy. In the regression model, @entity2 , higher comorbidity, performance of a tagged red blood cell nuclear scan, and surgery for hemostasis were significantly associated with a decreased likelihood of discharge. Having a colonoscopy was associated with an increased likelihood of being discharged compared with not having a colonoscopy at any given time point during hospitalization (hazard ratio 1.5: 95% CI[1.2, 1.8]. The mean lengths of stay for @entity0 having colonoscopy within 24 hours of hospitalization was shorter than those having colonoscopy after 24 hours of hospitalization (5.4 vs. 7.2 days; p<0.008). CONCLUSIONS: In @entity0 with @entity1 , earlier colonoscopy predicted earlier hospital discharge. However, colonoscopy did not necessarily lead to expedited post-procedural discharge. Although early colonoscopy appears to shorten hospital length of stay, prospective studies of inpatient colonoscopy are needed to determine the impact of this approach on outcomes.

title: Early colonoscopy for acute lower XXXX predicts shorter hospital stay: a retrospective study of experience in a single center.

answer: @entity1


abstract: The aim of this study was to compare the clinicopathological significance of @entity8 / @entity7 and @entity6 expression in @entity5 ( @entity5 ) versus nonendometrioid @entity2 (NECs) and to assess their correlation with hormone receptor status. @entity8 / @entity7 and @entity6 expression in 154 @entity3 was determined by qRT-PCR. The status of @entity1 and @entity4 receptor (ER/PR) was assessed using immunohistochemistry. @entity8 / @entity7 and @entity6 increased significantly in @entity5 and in NECs. The expression level of @entity8 was significantly higher in NECs than in @entity5 (P = 0.025). Furthermore, there was a trend that NECs with worse clinicopathological variables had a higher @entity8 expression, while an inverse trend existed in @entity5 . @entity6 upregulation occurred frequently in NECs without lymph node @entity0 (P = 0.030), whereas such association was not present in @entity5 . Interestingly, In @entity5 , @entity8 / @entity7 upregulation occurred frequently in the hormone receptor positive subgroups than the negative subgroups (P < 0.05). Similarly, the expression level of @entity6 was higher in the hormone receptor positive subgroups and the association between @entity6 and PR reached statistical significance (P = 0.024). In contrast, in NECs, a negative correlation was found between @entity8 / @entity7 and ER or PR status. Meanwhile, in @entity5 , @entity8 upregulation correlated with prolonged survival in the ER positive subgroup (P = 0.046), whereas an inverse trend existed in the ER negative subgroup. Our findings suggest that @entity8 / @entity7 and @entity6 increased significantly in @entity5 and in NECs. However, they might behave differently in @entity5 versus NECs. @entity8 / @entity7 and @entity6 might be associated with hormone receptor status in @entity3 and may possess prognostic impacts.

title: XXXX / @entity7 and @entity6 upregulation might be associated with hormone receptor status and prognosis in @entity3 .

answer: @entity8


abstract: The aim of this study was to compare the clinicopathological significance of @entity8 / @entity7 and @entity6 expression in @entity5 ( @entity5 ) versus nonendometrioid @entity2 (NECs) and to assess their correlation with hormone receptor status. @entity8 / @entity7 and @entity6 expression in 154 @entity3 was determined by qRT-PCR. The status of @entity1 and @entity4 receptor (ER/PR) was assessed using immunohistochemistry. @entity8 / @entity7 and @entity6 increased significantly in @entity5 and in NECs. The expression level of @entity8 was significantly higher in NECs than in @entity5 (P = 0.025). Furthermore, there was a trend that NECs with worse clinicopathological variables had a higher @entity8 expression, while an inverse trend existed in @entity5 . @entity6 upregulation occurred frequently in NECs without lymph node @entity0 (P = 0.030), whereas such association was not present in @entity5 . Interestingly, In @entity5 , @entity8 / @entity7 upregulation occurred frequently in the hormone receptor positive subgroups than the negative subgroups (P < 0.05). Similarly, the expression level of @entity6 was higher in the hormone receptor positive subgroups and the association between @entity6 and PR reached statistical significance (P = 0.024). In contrast, in NECs, a negative correlation was found between @entity8 / @entity7 and ER or PR status. Meanwhile, in @entity5 , @entity8 upregulation correlated with prolonged survival in the ER positive subgroup (P = 0.046), whereas an inverse trend existed in the ER negative subgroup. Our findings suggest that @entity8 / @entity7 and @entity6 increased significantly in @entity5 and in NECs. However, they might behave differently in @entity5 versus NECs. @entity8 / @entity7 and @entity6 might be associated with hormone receptor status in @entity3 and may possess prognostic impacts.

title: @entity8 / @entity7 and XXXX upregulation might be associated with hormone receptor status and prognosis in @entity3 .

answer: @entity6


abstract: The aim of this study was to compare the clinicopathological significance of @entity8 / @entity7 and @entity6 expression in @entity5 ( @entity5 ) versus nonendometrioid @entity2 (NECs) and to assess their correlation with hormone receptor status. @entity8 / @entity7 and @entity6 expression in 154 @entity3 was determined by qRT-PCR. The status of @entity1 and @entity4 receptor (ER/PR) was assessed using immunohistochemistry. @entity8 / @entity7 and @entity6 increased significantly in @entity5 and in NECs. The expression level of @entity8 was significantly higher in NECs than in @entity5 (P = 0.025). Furthermore, there was a trend that NECs with worse clinicopathological variables had a higher @entity8 expression, while an inverse trend existed in @entity5 . @entity6 upregulation occurred frequently in NECs without lymph node @entity0 (P = 0.030), whereas such association was not present in @entity5 . Interestingly, In @entity5 , @entity8 / @entity7 upregulation occurred frequently in the hormone receptor positive subgroups than the negative subgroups (P < 0.05). Similarly, the expression level of @entity6 was higher in the hormone receptor positive subgroups and the association between @entity6 and PR reached statistical significance (P = 0.024). In contrast, in NECs, a negative correlation was found between @entity8 / @entity7 and ER or PR status. Meanwhile, in @entity5 , @entity8 upregulation correlated with prolonged survival in the ER positive subgroup (P = 0.046), whereas an inverse trend existed in the ER negative subgroup. Our findings suggest that @entity8 / @entity7 and @entity6 increased significantly in @entity5 and in NECs. However, they might behave differently in @entity5 versus NECs. @entity8 / @entity7 and @entity6 might be associated with hormone receptor status in @entity3 and may possess prognostic impacts.

title: @entity8 / @entity7 and @entity6 upregulation might be associated with hormone receptor status and prognosis in XXXX .

answer: @entity3


abstract: The aim of this study was to compare the clinicopathological significance of @entity8 / @entity7 and @entity6 expression in @entity5 ( @entity5 ) versus nonendometrioid @entity2 (NECs) and to assess their correlation with hormone receptor status. @entity8 / @entity7 and @entity6 expression in 154 @entity3 was determined by qRT-PCR. The status of @entity1 and @entity4 receptor (ER/PR) was assessed using immunohistochemistry. @entity8 / @entity7 and @entity6 increased significantly in @entity5 and in NECs. The expression level of @entity8 was significantly higher in NECs than in @entity5 (P = 0.025). Furthermore, there was a trend that NECs with worse clinicopathological variables had a higher @entity8 expression, while an inverse trend existed in @entity5 . @entity6 upregulation occurred frequently in NECs without lymph node @entity0 (P = 0.030), whereas such association was not present in @entity5 . Interestingly, In @entity5 , @entity8 / @entity7 upregulation occurred frequently in the hormone receptor positive subgroups than the negative subgroups (P < 0.05). Similarly, the expression level of @entity6 was higher in the hormone receptor positive subgroups and the association between @entity6 and PR reached statistical significance (P = 0.024). In contrast, in NECs, a negative correlation was found between @entity8 / @entity7 and ER or PR status. Meanwhile, in @entity5 , @entity8 upregulation correlated with prolonged survival in the ER positive subgroup (P = 0.046), whereas an inverse trend existed in the ER negative subgroup. Our findings suggest that @entity8 / @entity7 and @entity6 increased significantly in @entity5 and in NECs. However, they might behave differently in @entity5 versus NECs. @entity8 / @entity7 and @entity6 might be associated with hormone receptor status in @entity3 and may possess prognostic impacts.

title: @entity8 / XXXX and @entity6 upregulation might be associated with hormone receptor status and prognosis in @entity3 .

answer: @entity7


abstract: Nonspecific clinical presentation of non-infectious, immune-mediated pulmonary complications of etanercept therapy makes the diagnosis difficult. While bronchoalveolar lavage fluid (BALF) cell analysis is frequently used in diagnosing drug-induced @entity2 , BALF patterns in etanercept-induced @entity5 (EILI) are not well established. Furthermore, previous reports of EILI diagnosis relied on transbronchial or surgical lung biopsies. Here, we report two @entity0 who developed @entity2 after etanercept treatment. Both @entity0 were diagnosed with EILI. While one @entity0 presented with @entity3 (+)-predominant @entity7 (consistent with a sarcoid-like pattern), the other @entity0 exhibited a @entity4 (+)-predominant pattern (consistent with @entity1 ). The different BAL patterns were accompanied by distinct radiographic findings. Both @entity0 significantly improved after etanercept discontinuation and corticosteroid initiation. We propose that EILI can present with distinct immunologic and radiographic phenotypes. In addition, early BALF analysis with lymphocyte immunophenotyping can further define the underlying @entity6 , and thereby, avoid more invasive procedures.

title: Distinct immunologic and radiographic patterns in etanercept-induced XXXX .

answer: @entity5


abstract: OBJECTIVE: To study the correlation between the angle of the pancreaticobiliary junction ( @entity2 ) and the prevalence of acute @entity1 using magnetic resonance cholangiopancreatography (MRCP). MATERIALS AND METHODS: From February 2014 to October 2014, thirty two subjects with normal pancreas (group A) and 40 @entity0 with acute @entity1 (group B) who underwent MRCP were enrolled into our study. The type of biliary duct and main pancreatic duct joining the duodenal wall was reviewed and divided into V, B-P and P-B type. The V type is the pancreatic duct and biliary duct joining the duodenal wall without a common channel; the B-P type is the biliary duct draining into the pancreatic duct and forming a common channel; and the P-B type is the pancreatic duct draining into the biliary duct and forming a common channel. @entity2 was measured on MRCP. The correlation between the @entity2 and the prevalence of acute @entity1 was analyzed. RESULTS: The @entity2 in group A was smaller than in group B (51.45    13.51   vs. 65.76    15.61  , P<0.05). According to the type of biliary duct and main pancreatic duct joining the duodenal wall, the prevalence of acute @entity1 in the V type and in the B-P type was higher than in the P-B type (12/17 vs. 10/29, or 18/26 vs. 10/29, respectively, all P<0.05), whereas there were no significant difference for the prevalence of acute @entity1 between the V type and B-P type (P>0.05). The @entity2 were 59.32    20.04  , 60.22    11.06  , 57.13    17.27  , respectively in V type, B-P type and P-B type joining of main pancreatic duct (P>0.05). CONCLUSIONS: A larger @entity2 is related to a higher prevalence of acute @entity1 .

title: The angle of pancreaticobiliary junction correlates with acute XXXX : a magnetic resonance cholangiopancreatography study.

answer: @entity1


abstract: @entity5 and @entity5 (IAH/ACS) are life-threatening conditions and caused by several clinical status. Although there is insufficient data regarding its effects on adrenal glands. This study aimed to identify whether elevated intra-abdominal pressure (IAP) caused any alteration on the morphology and function of adrenal glands in a @entity0 model. Twenty four Sprague-Dawley male @entity0 were included in the study. Animals were allocated into 4 groups. IAP was elevated to 15 mmHg for one hour and four hours in group 2 and 4. Group 1 and 3 were sham groups. Blood samples were taken for the assessment of plasma @entity2 , @entity1 , and @entity3 levels and adrenalectomies were performed to evaluate apoptosis. Blood @entity2 , @entity1 and @entity3 levels were significantly higher in the study groups compared with the sham groups. However, there were no significant changes in apoptotic index scores in the study groups as compared to sham groups. These results support that increased IAH leads to discharge of @entity4 and @entity3 from the adrenal glands. Failure to demonstrate similar changes in apoptotic index score may be concluded as apoptosis is not a leading pathway for impairment of adrenal glands during IAH period.

title: Effects of intra-abdominal pressure on adrenal gland function and morphology in XXXX .

answer: @entity0


abstract: We investigated a case of metastatic @entity8 at the left proximal femur, masquerading as a primary @entity5 . A 72-year-old @entity0 presented with @entity4 in her left thigh in conjunction with a mass that had been gradually growing over a few months. She was being treated with @entity9 for @entity8 positive for the @entity6 ( @entity6 ) mutation @entity11 , and had multiple bone @entity2 . The @entity8 and @entity2 had stabilized with the treatment. The metastatic lesions in the bone had also received radiation; however, a @entity3 in the proximal femur kept growing despite treatment. A biopsy specimen from the proximal femur revealed the proliferation of spindle-shaped cells without an epithelial glandular component. The @entity0 underwent en bloc resection of the proximal femur that was replaced by prosthesis. Histologically, the resected @entity3 was entirely composed of pleomorphic cells and @entity3 giant cells exhibiting no apparent glandular structures. @entity3 cells were diffusely positive for @entity7 and focally positive for epithelial markers and @entity6 , but were negative for @entity10 , suggesting an initial diagnosis of primary @entity5 . Genetic examination revealed mutations in @entity6 and @entity7 that were of the same type as the @entity1 , leading to the final diagnosis of the femoral mass as a sarcomatous transformation of metastatic @entity8 . However, secondary genetic alterations that might explain the acquired resistance to @entity9 could not be found in the proximal @entity3 . The @entity0 remains alive and the remaining lesions are well controlled.

title: Sarcomatous transformation of @entity6 and XXXX mutation-positive metastatic @entity8 , masquerading as a primary @entity5 of the proximal femur.

answer: @entity7