abstract: While reactive @entity0 species (ROS) play a role in muscle repair, excessive amounts of ROS for extended periods may lead to oxidative stress. Antioxidants, as @entity3 (RS), may reduce oxidative stress, restore mitochondrial function and promote myogenesis and @entity2 . However, RS dose-effectiveness for muscle plasticity is unclear. Therefore, we investigated RS dose-response on C2C12 myoblast and myotube plasticity 1. in the presence and 2. absence of different degrees of oxidative stress. Low RS concentration (10    M) stimulated myoblast cell cycle arrest, @entity4 and sprouting, which were inhibited by higher doses (40-60    M). RS did not increase oxidative capacity. In contrast, RS induced mitochondria loss, reduced cell viability and ROS production, and activated stress response pathways [Hsp70 and pSer36- @entity6 ( @entity5 ) proteins]. However, the deleterious effects of @entity1 (1000     M) on cell @entity4 were alleviated after preconditioning with 10     M-RS. This dose also enhanced cell motility mediated by 100     M- @entity1 , while higher RS-doses augmented the @entity1 -induced impaired myoblast regeneration and mitochondrial dehydrogenase activity. In conclusion, low @entity3 doses promoted in vitro muscle regeneration and attenuated the impact of ROS, while high doses augmented the reduced plasticity and metabolism induced by oxidative stress. Thus, the effects of @entity3 depend on its dose and degree of oxidative stress.

title: The impact of XXXX and hydrogen peroxide on muscle cell plasticity shows a dose-dependent interaction.

answer: @entity3


abstract: UNASSIGNED: The study aimed to evaluate the prognostic significance of prechemotherapy neutrophil to lymphocyte ratio and platelet to lymphocyte ratio, and preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in locally @entity2 . We analyzed retrospectively locally @entity2 @entity0 who had received neoadjuvant chemotherapy before undergoing a radical esophagectomy between 2009 and 2012. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio before chemotherapy and before the surgery were calculated. Univariate analyses showed that prechemotherapy neutrophil to lymphocyte ratio >5 (P = 0.048, hazard ratio = 2.86; 95% confidence interval: 1.01-8.12) and prechemotherapy platelet to lymphocyte ratio >130 (P = 0.025, hazard ratio = 5.50; 95% confidence interval: 1.23-24.55) were associated significantly with @entity1 ( @entity1 ), and prechemotherapy platelet to lymphocyte ratio >130 (P = 0.026, hazard ratio = 3.18; 95% confidence interval: 1.15-8.85) was associated significantly with progression-free survival. However, only prechemotherapy neutrophil to lymphocyte ratio >5 (P = 0.024, hazard ratio = 3.50; 95% confidence interval: 1.18-10.40) remained significantly associated with @entity1 in multivariate analyses. Neither preoperative neutrophil to lymphocyte ratio nor platelet to lymphocyte ratio was associated with @entity1 or progression-free survival. The prechemotherapy neutrophil to lymphocyte ratio >5 to preoperative neutrophil to lymphocyte ratio  <=5 group showed significantly worse @entity1 than the prechemotherapy neutrophil to lymphocyte ratio  <=5 to preoperative neutrophil to lymphocyte ratio  <=5 group (P = 0.050). The prechemotherapy platelet to lymphocyte ratio >130 to preoperative platelet to lymphocyte ratio  <=130 group (P = 0.016) and platelet to lymphocyte ratio >130 to preoperative platelet to lymphocyte ratio >130 group (P = 0.042) showed significantly worse @entity1 than the prechemotherapy platelet to lymphocyte ratio  <=30 to preoperative platelet to lymphocyte ratio  <=130 group. In conclusions, prechemotherapy neutrophil to lymphocyte ratio is an independent prognostic factor for @entity1 in @entity0 with @entity2 treated with neoadjuvant chemotherapy, and, as an adverse prognostic predictor, increased prechemotherapy neutrophil to lymphocyte ratio is superior to platelet to lymphocyte ratio. Maintaining a low neutrophil to lymphocyte ratio and platelet to lymphocyte ratio throughout treatment is a predictor of better @entity1 .

title: Prechemotherapy neutrophil   :   lymphocyte ratio is superior to the platelet   :   lymphocyte ratio as a prognostic indicator for locally XXXX treated with neoadjuvant chemotherapy.

answer: @entity2


abstract: UNASSIGNED: With the exception of @entity8 , genome-wide association studies have failed to identify strong genetic risk factors for late-onset @entity5 , despite strong evidence of heritability, suggesting that many low penetrance genes may be involved. Additionally, the nature of the identified genetic risk factors and their relation to disease pathology is also largely obscure. Previous studies have found that a @entity1 -associated variant of the cell cycle inhibitor gene @entity7 is associated with increased risk of @entity5 . The aim of this study was to confirm this association and to elucidate the effects of the variant on protein function and Alzheimer-type pathology. We examined the association of the @entity7 variant with @entity5 and @entity4 with @entity6 . The genotyping studies were performed on 719 @entity0 of the Oxford Project to Investigate Memory and Ageing, 225 @entity0 of a @entity4 DNA bank, and 477 @entity0 of the @entity0 Random Control collection available from the European Collection of Cell Cultures. The post mortem studies were carried out on 190 @entity0 . In the in-vitro study, @entity0 @entity2 were transfected with either the common or rare @entity7 variant; and cytometry was used to assess cell cycle kinetics, @entity7 protein expression and sub-cellular localisation. The variant was associated with an increased risk of @entity5 , and @entity4 with @entity6 , relative to age matched controls. Furthermore, the variant was associated with an earlier age of onset of @entity5 , and a more severe phenotype, with a primary influence on the accumulation of tangle pathology. In the in-vitro study, we found that the SNPs reduced the cell cycle inhibitory and anti-apoptotic activity of @entity7 . The results suggest that the @entity1 -associated variant of @entity7 may contribute to the loss of cell cycle control in neurons that may lead to @entity3 .

title: The Effects of Two Polymorphisms on XXXX Function and Their Association with @entity5 in a Population of European Descent.

answer: @entity7


abstract: UNASSIGNED: With the exception of @entity8 , genome-wide association studies have failed to identify strong genetic risk factors for late-onset @entity5 , despite strong evidence of heritability, suggesting that many low penetrance genes may be involved. Additionally, the nature of the identified genetic risk factors and their relation to disease pathology is also largely obscure. Previous studies have found that a @entity1 -associated variant of the cell cycle inhibitor gene @entity7 is associated with increased risk of @entity5 . The aim of this study was to confirm this association and to elucidate the effects of the variant on protein function and Alzheimer-type pathology. We examined the association of the @entity7 variant with @entity5 and @entity4 with @entity6 . The genotyping studies were performed on 719 @entity0 of the Oxford Project to Investigate Memory and Ageing, 225 @entity0 of a @entity4 DNA bank, and 477 @entity0 of the @entity0 Random Control collection available from the European Collection of Cell Cultures. The post mortem studies were carried out on 190 @entity0 . In the in-vitro study, @entity0 @entity2 were transfected with either the common or rare @entity7 variant; and cytometry was used to assess cell cycle kinetics, @entity7 protein expression and sub-cellular localisation. The variant was associated with an increased risk of @entity5 , and @entity4 with @entity6 , relative to age matched controls. Furthermore, the variant was associated with an earlier age of onset of @entity5 , and a more severe phenotype, with a primary influence on the accumulation of tangle pathology. In the in-vitro study, we found that the SNPs reduced the cell cycle inhibitory and anti-apoptotic activity of @entity7 . The results suggest that the @entity1 -associated variant of @entity7 may contribute to the loss of cell cycle control in neurons that may lead to @entity3 .

title: The Effects of Two Polymorphisms on @entity7 Function and Their Association with XXXX in a Population of European Descent.

answer: @entity5


abstract: Alternative splicing is a fundamental process of gene regulation that contributes to protein diversity, a common phenomenon in the @entity0 genome. Alternative splicing events not only happen in the normal gene regulation process, but are also closely related to certain diseases, including @entity1 . In this review, we briefly demonstrate the proof of concept (POC) of the relationship between alternative splicing and DNA damage, and describe the associations among alternative splicing and @entity1 pathogenesis, DNA damage, and @entity6 . We discuss whether alternative splicing leads to genetic instability, which is considered to be a driving force for tumorigenesis. @entity9 is a c-myc transcriptional suppressor. A splice variant of FIR that lacks exon 2 in the transcriptional repressor domain ( @entity9 exon2), upregulates c-myc transcription by inactivating wild-type FIR. FIR+/- m @entity2 exhibited marked c-myc mRNA upregulation, particularly in the peripheral blood (PB), without any significant pathogenic phenotype. Because the single knockout of T @entity4 generates t @entity7 FIR+/-T @entity4 /- m @entity2 developed T @entity8 (T @entity5 with increased organ or bone marrow invasion and showed a poor prognosis. After describing the POC of alternative splicing of FIR in DNA damage and c @entity3 clinical application for c @entity1 diagnosis and treatment by FIR/F @entity9 exon2 was briefly summarized. Chiba University has prepared a biobank to support studies to develop biomarker detection, molecular diagnosis, and "Omics" research. In conclusion, alternative splicing of FIR, generating FI @entity9 xon2, potentially contributes to not only colorectal car @entity3 ut also leukemogenesis, and a better understanding of the role and mechanism of alternative splicing in tumorigenesis may reveal new directions for can @entity1 omarker detection.

title: [Alternative Splicing Detection as Biomarker Candidates for XXXX Diagnosis and Treatment with Establishment of Clinical Biobank in Chiba University].

answer: @entity1


abstract: OBJECTIVE:: Adverse early life events are key factors for development of @entity4 ( @entity4 ). @entity3 ( @entity3 ) is associated with chronic @entity7 in adults, a finding that has been recapitulated in @entity1 models, but the relation between @entity5 has not been studied in @entity0 . We hypothesized that @entity3 in infancy increases the risk of @entity4 and @entity5 ( @entity5 ) in childhood. METHODS:: The present study included @entity0 , ages 4 to 18 years, with a single @entity3 in the first year of life and their siblings with no history of @entity3 . Parents completed the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III Version (QPGS-III) by telephone. @entity0 meeting QPGS-III criteria for @entity4 but with @entity2 less than once weekly were considered to have @entity5 . RESULTS:: A total of 57 @entity0 with @entity3 and 58 sibling controls were identified. Mean age at @entity3 was 4.8 months, and mean time since @entity3 was 9.3 years. At the time of survey, mean age of @entity0 was 9.7 years (5-16 years, 40% @entity0 ) and that of controls was 9.6 years (range 4-17 years, 57% @entity0 ). @entity4 were diagnosed in 6 of 57 (11%) @entity0 , and 1 of 58 (2%) controls (P=0.06). @entity5 was identified in 10 of 57 (18%) @entity0 and 2 of 58 (3%) controls (P=0.02). Predominant sex (female), infecting organism ( @entity6 ), and treatment (third-generation cephalosporin) were similar in @entity0 with @entity3 with and without @entity5 . CONCLUSIONS:: We show for the first time that @entity3 is associated with @entity5 in childhood. We speculate that pelvic organ sensory convergence explains our findings.

title: XXXX in Infancy Is a Risk Factor for Chronic @entity5 in Childhood.

answer: @entity3


abstract: OBJECTIVE:: Adverse early life events are key factors for development of @entity4 ( @entity4 ). @entity3 ( @entity3 ) is associated with chronic @entity7 in adults, a finding that has been recapitulated in @entity1 models, but the relation between @entity5 has not been studied in @entity0 . We hypothesized that @entity3 in infancy increases the risk of @entity4 and @entity5 ( @entity5 ) in childhood. METHODS:: The present study included @entity0 , ages 4 to 18 years, with a single @entity3 in the first year of life and their siblings with no history of @entity3 . Parents completed the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III Version (QPGS-III) by telephone. @entity0 meeting QPGS-III criteria for @entity4 but with @entity2 less than once weekly were considered to have @entity5 . RESULTS:: A total of 57 @entity0 with @entity3 and 58 sibling controls were identified. Mean age at @entity3 was 4.8 months, and mean time since @entity3 was 9.3 years. At the time of survey, mean age of @entity0 was 9.7 years (5-16 years, 40% @entity0 ) and that of controls was 9.6 years (range 4-17 years, 57% @entity0 ). @entity4 were diagnosed in 6 of 57 (11%) @entity0 , and 1 of 58 (2%) controls (P=0.06). @entity5 was identified in 10 of 57 (18%) @entity0 and 2 of 58 (3%) controls (P=0.02). Predominant sex (female), infecting organism ( @entity6 ), and treatment (third-generation cephalosporin) were similar in @entity0 with @entity3 with and without @entity5 . CONCLUSIONS:: We show for the first time that @entity3 is associated with @entity5 in childhood. We speculate that pelvic organ sensory convergence explains our findings.

title: @entity3 in Infancy Is a Risk Factor for Chronic XXXX in Childhood.

answer: @entity5


abstract: BACKGROUND: Nature images are frequently used for therapeutic purposes in hospital settings. Nature images may distract @entity0 from @entity1 and promote psychological and physiological well-being, yet limited research is available to guide the selection process of nature images. OBJECTIVE: The hypothesis is that higher degrees of presence and/or influence in the still photograph make it more effective at holding the viewer's attention, which therefore may distract the viewer from @entity1 , and therefore be considered therapeutic. Research questions include: (1) Is there a significant difference in the level of perceived presence among the selected images? (2) Is there a significant difference in the level of perceived influence among the selected images? (3) Is there a correlation between levels of presence and levels of influence? METHODS: 109 college students were randomly assigned to one of four different image categories defined by Appleton's prospect refuge theory of landscape preference. Categories included prospect, refuge, hazard, and mixed prospect and refuge. A control group was also included. Each investigation was divided into five periods: prereporting, rest, a @entity1 stressor (hand in ice water for up to 120 seconds), recovery, and postreporting. Physiological readings (vital signs) were measured repeatedly using a Dinamap automatic vital sign tracking machine. Psychological responses (mood) to the image were collected using a reliable instrument, the Profile of Mood States. RESULTS: No significant statistical difference in levels of presence was found among the four image categories. However, levels of influence differed and the hazard nature image category had significantly higher influence ratings and lower diastolic blood pressure readings during the @entity1 treatment. A correlation (r = .62) between presence and influence was identified; as one rose, so did the other. Mood state was significantly low for the hazard nature image after the @entity1 stressor experience. CONCLUSIONS: Though the hazard image caused distraction from @entity1 , it is nontherapeutic because of the low mood ratings it received. These preliminary findings contribute methodology to the research field and stimulate interest for additional research into the visual effects of nature images on @entity1 .

title: The effects of presence and influence in nature images in a simulated hospital XXXX room.

answer: @entity0


abstract: BACKGROUND The results of @entity0 in a large degree on appropriate @entity3 allograft donor selection. Several risk factors of early surgical complications or @entity3 allograft loss following transplantation have been identified, but the final decision on @entity3 harvesting for transplantation belongs to the surgeon. In the present study we aimed to assess whether histopathological examination may be utilized for detection of @entity1 and @entity5 in tissue from a potential @entity3 allograft. Additionally, we aimed to test whether presence of pancreatic @entity1 and @entity5 may be explained solely by donor age and/or body mass index (BMI). MATERIAL AND METHODS Pancreata retrieved from 50 deceased organ donors referred to our institution and not transplanted between 2010 and 2013 were used for the present study. Tissue samples were excised from pancreata, fixed in @entity2 , and embedded in @entity4 . Presence and intensity of pancreatic @entity1 and @entity5 were assessed semi-quantitatively. RESULTS @entity1 was found in the majority of study samples (72%), but it was usually mild or moderate. @entity5 was present in 34% of the study cases. Presence of @entity1 was more frequent in older donors, but was still not rare in donors under 40 years old. Presence of @entity5 did not seem to be significantly related to donor age. Neither pancreatic @entity1 nor @entity5 was related to donor BMI. CONCLUSIONS There is no clear relationship between histological parenchymal changes in potential @entity3 allograft and donor age and BMI. Histopathological assessment of pancreatic @entity1 and/or @entity5 can potentially facilitate decision making on @entity3 allograft acceptance for solid organ transplantation.

title: Histopathological Examination may be Useful for Assessment of XXXX and Lipomatosis of Pancreas Allograft Prior to Solid Organ Transplantation.

answer: @entity1


abstract: INTRODUCTION: Chronic @entity4 media, apart from destruction of bones and possibility of otogenous complications, is characterized by possibility of recurrence of the disease after non radical treatment or presence of risk factors. AIM: This paper intends to analyze changes typical for @entity4 , observed during otosurgery including the results of bacteriological investigations. MATERIAL AND METHODS: Nearly 450 otosurgeries were performed in Department of Otolaryngology at Jagiellonian University 2004-2007. Analysis refers to @entity0 reoperated on chronic @entity4 media. RESULTS: 47 reoperations in the course of chronic @entity3 media were performed. Bacteriological analysis was provided in 21 cases. The most common bacteria were @entity1 and @entity2 . Biofilms were not observed in specimens. CONCLUSIONS: The recurrence of the process should be expected in @entity0 with @entity4 . They require regular, periodical follow-up examination.

title: [Reoperations in XXXX with chronic otitis media cholesteatomatosa].

answer: @entity0


abstract: BACKGROUND AND PURPOSE: The present study was undertaken to investigate an effect of @entity5 , a potent arrhythmic blocker of the voltage-gated @entity6 channel, @entity9 , on cardiac autonomic control. Combined with effects on ardiomyocytes, these properties could influence its arrhythmic potency. EXPERIMENTAL APPROACH: The short-term variability of beat-to-beat QT interval (STVQT ), induced by @entity5 is a strong surrogate of @entity3 . Involvement of autonomic modulation in STVQT was investigated in healthy @entity8 and @entity1 by power spectral analysis under conditions of autonomic blockade with @entity7 . KEY RESULTS: Increase in STVQT induced by @entity5 in monkeys and @entity1 was closely associated with an enhancement of endogenous heart rate and @entity4 . These effects were fully suppressed under conditions of autonomic blockade with @entity7 . @entity2 , including @entity3 in monkeys, were prevented in both species @entity4 were suppressed by autonomic blockade. Similar enhancements of heart rate @entity4 were found in @entity1 with other @entity9 blockers described as causing @entity3 in @entity0 . CONCLUSIONS AND IMPLICATIONS: These results demonstrate for the first time that beat-to-beat ventricular repolarization variability and @entity2 induced by @entity5 are dependent on endogenous HF autonomic oscillations in heart rate. When combined with evidence of @entity9 -blocking properties, enhancement of endogenous @entity4 in heart rate could constitute an earlier and more sensitive biomarker than STVQT for @entity3 , applicable to preclinical regulatory studies conducted in healthy animals.

title: Short-term variability in QT interval and XXXX induced by @entity5 are dependent on high-frequency autonomic oscillations.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: The present study was undertaken to investigate an effect of @entity5 , a potent arrhythmic blocker of the voltage-gated @entity6 channel, @entity9 , on cardiac autonomic control. Combined with effects on ardiomyocytes, these properties could influence its arrhythmic potency. EXPERIMENTAL APPROACH: The short-term variability of beat-to-beat QT interval (STVQT ), induced by @entity5 is a strong surrogate of @entity3 . Involvement of autonomic modulation in STVQT was investigated in healthy @entity8 and @entity1 by power spectral analysis under conditions of autonomic blockade with @entity7 . KEY RESULTS: Increase in STVQT induced by @entity5 in monkeys and @entity1 was closely associated with an enhancement of endogenous heart rate and @entity4 . These effects were fully suppressed under conditions of autonomic blockade with @entity7 . @entity2 , including @entity3 in monkeys, were prevented in both species @entity4 were suppressed by autonomic blockade. Similar enhancements of heart rate @entity4 were found in @entity1 with other @entity9 blockers described as causing @entity3 in @entity0 . CONCLUSIONS AND IMPLICATIONS: These results demonstrate for the first time that beat-to-beat ventricular repolarization variability and @entity2 induced by @entity5 are dependent on endogenous HF autonomic oscillations in heart rate. When combined with evidence of @entity9 -blocking properties, enhancement of endogenous @entity4 in heart rate could constitute an earlier and more sensitive biomarker than STVQT for @entity3 , applicable to preclinical regulatory studies conducted in healthy animals.

title: Short-term variability in QT interval and @entity2 induced by XXXX are dependent on high-frequency autonomic oscillations.

answer: @entity5


abstract: UNASSIGNED: In @entity0 , @entity2 delays the onset of sweating and cutaneous vasodilation during heat stress. However, it remains unknown if hyperosmolality exerts this effect through a central (i.e. central nervous system) and/or peripheral (i.e. effector organ) modulation of thermoregulatory activity. We examined if intravenous infusion of hyperosmotic saline affects skin sympathetic nerve activity (SSNA) during whole-body passive heating in healthy @entity0 . Furthermore, we examined if local intradermal infusion of hyperosmotic saline affects sweating and cutaneous vasodilation during passive heating. Following intravenous infusion of either 0.9% ( @entity3 ) or 3.0% (HYPER) @entity1 saline, 12 subjects were passively heated until core temperature increased by    0.6  C. During each condition, sweating and cutaneous vascular conductance were measured over two intradermal microdialysis probes, one perfused with @entity3 saline and the other with HYPER saline. Intravenous infusion of HYPER saline increased plasma osmolality (294      3 to 316      5 mOsm/kgH2 O, P   <=  0.01), which remained greater than @entity3 throughout heating. Plasma hyperosmolality delayed the mean body temperature onset of sweating (+1.24      0.18  vs. +1.60      0.18  C, P   <=  0.01) and cutaneous vasodilation (+1.15      0.18  vs. +1.53      0.22  C, P   <=  0.01), and attenuated the increase in SSNA during heating (+147      178  vs. +427      281%, P   <=  0.01). Intradermal infusion of HYPER saline increased baseline CVC (P   <=  0.01), which did not increase further during the subsequent heating period (P  =  0.11). In contrast, intradermal infusion of HYPER saline did not affect sweating (P  =  0.99). These results provide direct evidence that @entity2 exerts a central modulatory effect governing efferent thermoregulatory activity in @entity0 . This article is protected by copyright. All rights reserved.

title: Plasma hyperosmolality attenuates skin sympathetic nerve activity during passive heat stress in XXXX .

answer: @entity0


abstract: UNASSIGNED: Sleep is beneficial to learning, but the underlying mechanisms remain controversial. The synaptic homeostasis hypothesis (SHY) proposes that the cognitive function of sleep is related to a generalized rescaling of synaptic weights to intermediate levels, due to a passive downregulation of plasticity mechanisms. A competing hypothesis proposes that the active upscaling and downscaling of synaptic weights during @entity0 memories in circuits respectively activated or deactivated during prior waking experience, leading to memory changes beyond rescaling. Both theories have empirical support but the experimental designs underlying the conflicting studies are not congruent, therefore a consensus is yet to be reached. To advance this issue, we used real-time PCR and electrophysiological recordings to assess gene expression related to synaptic plasticity in the hippocampus and primary somatosensory cortex of @entity1 exposed to novel objects, then kept awake (WK) for 60min and finally killed after a 30min period rich in WK, @entity0 ( @entity0 ) or @entity4 ( @entity4 ). Animals similarly treated but not exposed to novel objects were used as controls. We found that the mRNA levels of Arc, @entity5 , @entity3 , @entity9 and @entity10 were significantly increased in the hippocampus of exposed animals allowed to enter @entity4 , in comparison with control animals. Experience-dependent changes during sleep were not significant in the hippocampus for @entity2 , @entity8 , @entity6 , and @entity7 , and no differences were detected between exposed and control @entity0 groups for any of the genes tested. No significant changes in gene expression were detected in the primary somatosensory cortex during sleep, in contrast with previous studies using longer post-stimulation intervals (>180min). The experience-dependent induction of multiple plasticity-related genes in the hippocampus during early @entity4 adds experimental support to the synaptic embossing theory.

title: Experience-dependent upregulation of multiple plasticity factors in the hippocampus during early XXXX sleep.

answer: @entity4


abstract: BACKGROUND: Anti- @entity1 ( @entity1 ) encephalitis is an autoimmune disorder of the central nervous system which presents acutely with seizures, disturbances in consciousness and behavioural change. Although there is an increasing amount of information about the diagnosis and acute treatment strategies, little is known about rehabilitation needs and outcomes for this @entity0 group. CASE REPORT: This study presents a 52-year old @entity0 who initially presented with generalized seizures and drowsiness. She was admitted to hospital where autoimmune encephalitis was diagnosed based on a positive serum anti- @entity1 antibody titre. When medically stabilized, she was transferred to a specialist neurorehabilitation unit for ongoing care. Her main clinical issues were around behavioural disturbance, communication, continence, mobility and cognition. A multi-disciplinary approach was taken to her problems and she was eventually discharged back to community living having made substantial improvements in all domains of functioning. The clinical challenges encountered throughout her rehabilitation and the approach to ameliorating these is described. CONCLUSION: Although having a relatively rare diagnosis, the specific rehabilitation needs of this @entity0 were met through an existing specialist neurorehabilitation service. A broader case series is required to determine needs and effective approaches across this @entity0 group as a whole.

title: Rehabilitation following anti- XXXX encephalitis.

answer: @entity1


abstract: Periodontal @entity1 cause inflammatory destruction of the tooth supporting tissues. We recently developed a dynamic, in vitro periodontal organotypic tissue model in a perfusion bioreactor system, in co-culture with an 11-species subgingival biofilm, which may recapitulate early events during the establishment of periodontal @entity1 . This study aimed to characterize the global proteome regulations in this host-biofilm interaction model. Semi-quantitative shotgun proteomics were applied for protein identification and quantification in the co-culture supernatants ( @entity0 and bacterial) and the biofilm lysates (bacterial). A total of 896 and 3363 proteins were identified as secreted in the supernatant and expressed in the biofilm lysate, respectively. Enriched gene ontology analysis revealed that the regulated secreted @entity0 tissue proteins were related to processes of cytoskeletal rearrangement, stress responses, apoptosis, and antigen presentation, all of which are commensurate with deregulated host responses. Most secreted bacterial biofilm proteins derived from their cytoplasmic domain. In the presence of the tissue, the levels of @entity2 , Actinomyces oris and Campylobacter rectus proteins were significantly regulated. The functions of the up-regulated intracellular (biofilm lysate) proteins were associated with cytokinesis. In conclusion, the proteomic overview of regulated pathways in this host-biofilm interaction model provides insights to the early events of periodontal pathogenesis.

title: Proteomic profiling of host-biofilm interactions in an XXXX model resembling the periodontal pocket.

answer: @entity1


abstract: BACKGROUND: Inpatient antiarrhythmic drug initiation for @entity3 is mandated for @entity9 (DF) and is often performed for @entity8 (SL), particularly if proarrhythmia risk factors are present. Whether low-risk @entity0 can be identified to safely allow outpatient initiation is unknown. METHODS: A single-center retrospective cohort study was performed on @entity0 initiated with DF or SL. Risk factors for adverse events (AEs), defined as any @entity2 or electrocardiogram change requiring dose reduction or cessation, were identified. RESULTS: Of 329 @entity0 , 227 (69%) received SL and 102 (31%) DF. The cohort had a mean age of 63      13 years; 70% of @entity0 were male and had a baseline QTc of 440      37 ms. A total of 105 AEs occurred in 92 @entity0 : @entity4 or @entity5 in 70 @entity0 (67% of AEs), @entity7 in 35 @entity0 (33% of AEs), with some experiencing both AE types. @entity2 were seen in 23 @entity0 (7%) and @entity6 in one (0.3%). Total AE rates were similar between drugs (P = 0.09); however, DF @entity0 had more @entity4 or @entity2 (P = 0.001). In SL @entity0 , there were no predictors for @entity4 or @entity1 . In DF @entity0 , higher baseline QTc interval (odds ratio = 1.64/25 ms, P = 0.01) was an independent predictor of @entity4 . For @entity0 without proarrhythmia risk factors, overall AE rate was 26%. CONCLUSIONS: In conclusion, AEs are common during DF and SL initiation but rarely severe in hospitalized inpatients. Baseline QTc predicts AEs for DF @entity0 only and AE are common even in "low-risk" @entity0 . These results support in-hospital drug initiation for all DF and SL @entity0 .

title: Risk Prediction for Adverse Events during Initiation of @entity8 and XXXX for the Treatment of @entity3 .

answer: @entity9


abstract: BACKGROUND: Inpatient antiarrhythmic drug initiation for @entity3 is mandated for @entity9 (DF) and is often performed for @entity8 (SL), particularly if proarrhythmia risk factors are present. Whether low-risk @entity0 can be identified to safely allow outpatient initiation is unknown. METHODS: A single-center retrospective cohort study was performed on @entity0 initiated with DF or SL. Risk factors for adverse events (AEs), defined as any @entity2 or electrocardiogram change requiring dose reduction or cessation, were identified. RESULTS: Of 329 @entity0 , 227 (69%) received SL and 102 (31%) DF. The cohort had a mean age of 63      13 years; 70% of @entity0 were male and had a baseline QTc of 440      37 ms. A total of 105 AEs occurred in 92 @entity0 : @entity4 or @entity5 in 70 @entity0 (67% of AEs), @entity7 in 35 @entity0 (33% of AEs), with some experiencing both AE types. @entity2 were seen in 23 @entity0 (7%) and @entity6 in one (0.3%). Total AE rates were similar between drugs (P = 0.09); however, DF @entity0 had more @entity4 or @entity2 (P = 0.001). In SL @entity0 , there were no predictors for @entity4 or @entity1 . In DF @entity0 , higher baseline QTc interval (odds ratio = 1.64/25 ms, P = 0.01) was an independent predictor of @entity4 . For @entity0 without proarrhythmia risk factors, overall AE rate was 26%. CONCLUSIONS: In conclusion, AEs are common during DF and SL initiation but rarely severe in hospitalized inpatients. Baseline QTc predicts AEs for DF @entity0 only and AE are common even in "low-risk" @entity0 . These results support in-hospital drug initiation for all DF and SL @entity0 .

title: Risk Prediction for Adverse Events during Initiation of @entity8 and @entity9 for the Treatment of XXXX .

answer: @entity3


abstract: BACKGROUND: Inpatient antiarrhythmic drug initiation for @entity3 is mandated for @entity9 (DF) and is often performed for @entity8 (SL), particularly if proarrhythmia risk factors are present. Whether low-risk @entity0 can be identified to safely allow outpatient initiation is unknown. METHODS: A single-center retrospective cohort study was performed on @entity0 initiated with DF or SL. Risk factors for adverse events (AEs), defined as any @entity2 or electrocardiogram change requiring dose reduction or cessation, were identified. RESULTS: Of 329 @entity0 , 227 (69%) received SL and 102 (31%) DF. The cohort had a mean age of 63      13 years; 70% of @entity0 were male and had a baseline QTc of 440      37 ms. A total of 105 AEs occurred in 92 @entity0 : @entity4 or @entity5 in 70 @entity0 (67% of AEs), @entity7 in 35 @entity0 (33% of AEs), with some experiencing both AE types. @entity2 were seen in 23 @entity0 (7%) and @entity6 in one (0.3%). Total AE rates were similar between drugs (P = 0.09); however, DF @entity0 had more @entity4 or @entity2 (P = 0.001). In SL @entity0 , there were no predictors for @entity4 or @entity1 . In DF @entity0 , higher baseline QTc interval (odds ratio = 1.64/25 ms, P = 0.01) was an independent predictor of @entity4 . For @entity0 without proarrhythmia risk factors, overall AE rate was 26%. CONCLUSIONS: In conclusion, AEs are common during DF and SL initiation but rarely severe in hospitalized inpatients. Baseline QTc predicts AEs for DF @entity0 only and AE are common even in "low-risk" @entity0 . These results support in-hospital drug initiation for all DF and SL @entity0 .

title: Risk Prediction for Adverse Events during Initiation of XXXX and @entity9 for the Treatment of @entity3 .

answer: @entity8


abstract: The "cellular effect" i.e. temporary elevation of @entity6 titer may not be infrequently experienced during course of chemotherapy against @entity3 . Present paper is to clarify real view of the effect and mechanism of its manifestation by using a cell-line (GCH-nu). 1) Cellular growth was suppressed moderately by 10(-7), 10(-6) and 10(-5)M @entity4 . 2) During 2-4 days of administration at these concentrations of @entity4 @entity6 per ml medium was elevated 5 times. @entity6 in cells per mg protein were also higher 5-7 times. 3) @entity6 -beta in media was enhanced 5-7 times in @entity4 group. 4) @entity5 , @entity0 and @entity2 were not altered. 5) @entity3 cells developed marked enlargement of nuclei and cells, multinucleation and cytoplasmic vacuolization. 6) Cytochemistry of heat stable ALP revealed increased activity especially in cells with morphological changes. ALP examined by biochemical method was enhanced 5 times. 7) Amount of protein per cell increased 10 times after giving @entity4 . Real view of so-called "cellular effect" includes elevations of @entity6 -beta and ALP activity as well as @entity6 , whereas sex @entity1 are not apparently related. The data in addition to morphological and cytochemical changes reveal that @entity4 may induce differentiation of @entity3 cells into those of syncytial type, which then sustain the "cellular effect".

title: [Study on so called "cellular effect" of methotrexate on XXXX and its mode of manifestation (author's transl)].

answer: @entity3


abstract: Immunohistochemical methods were used to characterize the expression of two @entity0 -binding proteins, calretinin (CR) and S100, in the olfactory rosette of the adult @entity2 . These proteins are expressed in different sets of sensory neurons, and together represent a large proportion of these cells. Double immunofluorescence for CR and Ga(olf) protein, and CR immunoelectron microscopy, indicated that most CR-immunoreactive (ir) cells were ciliary neurons. Differential S100- and CR-ir projections to glomerular fields of the olfactory bulb were also observed, although these projections overlap in some glomeruli. Application of the @entity6 dye @entity5 to either S100-ir or CR-ir glomerular regions led to labeling of cells mostly similar to S100-ir and CR-ir neurons, respectively. Instead, these bulbar regions project to similar @entity3 targets. On the other hand, antibodies against keyhole limpet hemocyanin (KLH)-stained numerous sensory cells in the olfactory rosette, including cells that were CR- and S100-negative. This antiserum also stained most primary bulbar projections and revealed extrabulbar olfactory primary projections coursing to the ventral area of the telencephalon through the medial olfactory tract. This extrabulbar projection was confirmed by tract-tracing with @entity5 . A loose association of this extrabulbar primary olfactory projection and the catecholaminergic populations of the ventral area was also observed with double @entity1 hydroxylase/KLH-like immunohistochemistry. Comparison between KLH-like-ir pathways and the structures revealed by @entity4 immunohistochemistry (a marker of terminal ganglion cells and fibers) indicated that the KLH-like-ir extrabulbar projection was different from the terminal nerve system. The significance of the extrabulbar olfactory projection of @entity2 is discussed.

title: Differential bulbar and extrabulbar projections of diverse olfactory receptor neuron populations in the adult XXXX ( @entity2 ).

answer: @entity2


abstract: Immunohistochemical methods were used to characterize the expression of two @entity0 -binding proteins, calretinin (CR) and S100, in the olfactory rosette of the adult @entity2 . These proteins are expressed in different sets of sensory neurons, and together represent a large proportion of these cells. Double immunofluorescence for CR and Ga(olf) protein, and CR immunoelectron microscopy, indicated that most CR-immunoreactive (ir) cells were ciliary neurons. Differential S100- and CR-ir projections to glomerular fields of the olfactory bulb were also observed, although these projections overlap in some glomeruli. Application of the @entity6 dye @entity5 to either S100-ir or CR-ir glomerular regions led to labeling of cells mostly similar to S100-ir and CR-ir neurons, respectively. Instead, these bulbar regions project to similar @entity3 targets. On the other hand, antibodies against keyhole limpet hemocyanin (KLH)-stained numerous sensory cells in the olfactory rosette, including cells that were CR- and S100-negative. This antiserum also stained most primary bulbar projections and revealed extrabulbar olfactory primary projections coursing to the ventral area of the telencephalon through the medial olfactory tract. This extrabulbar projection was confirmed by tract-tracing with @entity5 . A loose association of this extrabulbar primary olfactory projection and the catecholaminergic populations of the ventral area was also observed with double @entity1 hydroxylase/KLH-like immunohistochemistry. Comparison between KLH-like-ir pathways and the structures revealed by @entity4 immunohistochemistry (a marker of terminal ganglion cells and fibers) indicated that the KLH-like-ir extrabulbar projection was different from the terminal nerve system. The significance of the extrabulbar olfactory projection of @entity2 is discussed.

title: Differential bulbar and extrabulbar projections of diverse olfactory receptor neuron populations in the adult @entity2 ( XXXX ).

answer: @entity2


abstract: INTRODUCTION: @entity1 ( @entity1 ) is a stigmatised condition that remains a silent affliction for many populations. To date, no local study has been performed to determine its prevalence in our population. The existing literature from the West has shown highly variable rates, ranging from 0.8% to 18.0%. The aim of this study was to determine the cross-sectional prevalence of @entity1 in Singapore and to identify at-risk groups. METHODS: A door-to-door questionnaire survey was performed between February and March 2013. We randomly selected 1,000 individuals from the electoral roll to be surveyed using the validated Comprehensive @entity2 . RESULTS: A total of 381 @entity0 agreed to be enrolled in the study. The mean age of the @entity0 was 52 (range 21-86) years, and slightly more than half of the @entity0 were female (52.8%). Among the female @entity0 , 73.1% had @entity0 (78.8% underwent normal vaginal delivery). The overall prevalence of @entity1 in our study population was 4.7%. The prevalence of @entity1 was observed to be significantly associated with increasing age (p = 0.004) and female gender (p = 0.029); @entity0 were three times more likely to suffer from @entity1 than @entity0 . CONCLUSION: With the ageing population of Singapore, the results of the present study provide further impetus to continue public outreach efforts as well as develop clinical programmes that address the growing need for specialist treatments for @entity0 with @entity1 .

title: Prevalence of XXXX in the community: a cross-sectional study in Singapore.

answer: @entity1


abstract: UNASSIGNED: The aim of the current study was to investigate basic emotions and attachment in a sample of 86 @entity1 @entity0 . We included a control group of 115 orthopedic @entity0 (matched for age and cognitive status) without @entity2 to control for unspecific general illness effects of a traumatic recent event on basic emotions and attachment. In order to measure basic emotions and attachment style we applied the Affective Neuroscience Personality Scale (ANPS) and the Attachment Style Questionnaire (ASQ). The @entity1 @entity0 showed significantly different scores in the SEEKING, SADNESS, and ANGER subscales of the ANPS as well as in the Relationship as Secondary Attachment dimension of the ASQ when compared to the control group. These differences show a pattern influenced by lesion location mainly as concerns basic emotions. Anterior, medial, left, and subcortical @entity0 provide scores significantly lower in ANPS-SEEKING than the control group; ANPS-SADNESS scores in anterior, right, medial, and subcortical @entity0 were significantly higher than those of the control group. ANPS-ANGER scores in posterior, right, and lateral @entity0 were significantly higher than those in the control group; finally, the ANPS-FEAR showed slightly lower scores in posterior @entity0 than in the control group. Minor effects on @entity2 were also individuated in the attachment style. @entity2 @entity0 showed a significantly higher average score in the ASQ-Need for Approval subscale than the control group. ASQ-Confidence subscale scores differed significantly in @entity1 @entity0 with lesions in medial brain regions when compared to control subjects. Scores at ANPS and ASQ subscales appear significantly more correlated in @entity1 @entity0 than in the control group. Such finding of abnormalities, especially concerning basic emotions in @entity1 brain-lesioned @entity0 , indicates that the effect of @entity2 may enhance the interrelation between basic emotions and attachment with respect to the control group.

title: Do @entity2 in XXXX affect basic emotions and attachment?

answer: @entity1


abstract: UNASSIGNED: The aim of the current study was to investigate basic emotions and attachment in a sample of 86 @entity1 @entity0 . We included a control group of 115 orthopedic @entity0 (matched for age and cognitive status) without @entity2 to control for unspecific general illness effects of a traumatic recent event on basic emotions and attachment. In order to measure basic emotions and attachment style we applied the Affective Neuroscience Personality Scale (ANPS) and the Attachment Style Questionnaire (ASQ). The @entity1 @entity0 showed significantly different scores in the SEEKING, SADNESS, and ANGER subscales of the ANPS as well as in the Relationship as Secondary Attachment dimension of the ASQ when compared to the control group. These differences show a pattern influenced by lesion location mainly as concerns basic emotions. Anterior, medial, left, and subcortical @entity0 provide scores significantly lower in ANPS-SEEKING than the control group; ANPS-SADNESS scores in anterior, right, medial, and subcortical @entity0 were significantly higher than those of the control group. ANPS-ANGER scores in posterior, right, and lateral @entity0 were significantly higher than those in the control group; finally, the ANPS-FEAR showed slightly lower scores in posterior @entity0 than in the control group. Minor effects on @entity2 were also individuated in the attachment style. @entity2 @entity0 showed a significantly higher average score in the ASQ-Need for Approval subscale than the control group. ASQ-Confidence subscale scores differed significantly in @entity1 @entity0 with lesions in medial brain regions when compared to control subjects. Scores at ANPS and ASQ subscales appear significantly more correlated in @entity1 @entity0 than in the control group. Such finding of abnormalities, especially concerning basic emotions in @entity1 brain-lesioned @entity0 , indicates that the effect of @entity2 may enhance the interrelation between basic emotions and attachment with respect to the control group.

title: Do XXXX in @entity1 affect basic emotions and attachment?

answer: @entity2


abstract: Clinical and electrophysiologic characteristics associated with spontaneous and inducible @entity3 and @entity4 were assessed in 20 consecutive @entity0 with @entity6 undergoing surgical division (n = 12) or transcatheter electrical ablation (n = 8) of accessory pathways. @entity0 with spontaneous @entity3 were characterized by the trend (not significant) of a shorter antegrade accessory pathway effective refractory period (256 +/- 26 vs 303 +/- 109 msec). However, @entity0 with and without spontaneous @entity3 did not differ with respect to prevalence of structural @entity1 (3 of 11 vs 2 of 9), intra-atrial conduction time (34 +/- 10 vs 32 +/- 10 msec), or interatrial conduction time (86 +/- 21 vs 88 +/- 17 msec). Thus, atrial and accessory pathway electrophysiologic properties (per se) were not clear determinants of susceptibility to @entity3 . Among the 20 @entity0 , 10 to 35 beats of nonsustained @entity4 (seven @entity0 ) or @entity5 (three @entity0 ) were induced at electrophysiologic study with one to three programmed extrastimuli. Clinically, a @entity2 ( @entity5 during @entity3 ) had occurred in only one of these @entity0 . The discordance of these observations was significant (p less than 0.01). @entity0 with and without inducible @entity2 were not distinguished by clinical factors or by electrophysiologic properties of the accessory pathway or ventricles. Accessory pathway conduction was completely or partially eliminated by ablation procedures in 14 of 20 @entity0 . During a mean follow-up of 27 months, @entity3 recurred in two @entity0 with failed ablation procedures and in one @entity0 with @entity7 (despite accessory pathway division) (p = 0.019 vs pre-ablation). @entity2 remained inducible in two @entity0 in whom accessory pathway ablation failed (p = 0.01 vs initial study). However, spontaneous @entity4 did not occur during follow-up. We conclude that susceptibility to spontaneous or inducible @entity3 and @entity4 in @entity0 with @entity6 and no @entity1 depends primarily on the existence of a functional accessory pathway. These susceptibilities are eliminated by interruption of accessory pathway conduction. @entity4 remain infrequent spontaneous events in the @entity6 . Their more frequent induction at electrophysiologic study is not predictive of clinical occurrence.

title: Susceptibility to @entity3 and @entity4 in the XXXX : role of the accessory pathway.

answer: @entity6


abstract: Clinical and electrophysiologic characteristics associated with spontaneous and inducible @entity3 and @entity4 were assessed in 20 consecutive @entity0 with @entity6 undergoing surgical division (n = 12) or transcatheter electrical ablation (n = 8) of accessory pathways. @entity0 with spontaneous @entity3 were characterized by the trend (not significant) of a shorter antegrade accessory pathway effective refractory period (256 +/- 26 vs 303 +/- 109 msec). However, @entity0 with and without spontaneous @entity3 did not differ with respect to prevalence of structural @entity1 (3 of 11 vs 2 of 9), intra-atrial conduction time (34 +/- 10 vs 32 +/- 10 msec), or interatrial conduction time (86 +/- 21 vs 88 +/- 17 msec). Thus, atrial and accessory pathway electrophysiologic properties (per se) were not clear determinants of susceptibility to @entity3 . Among the 20 @entity0 , 10 to 35 beats of nonsustained @entity4 (seven @entity0 ) or @entity5 (three @entity0 ) were induced at electrophysiologic study with one to three programmed extrastimuli. Clinically, a @entity2 ( @entity5 during @entity3 ) had occurred in only one of these @entity0 . The discordance of these observations was significant (p less than 0.01). @entity0 with and without inducible @entity2 were not distinguished by clinical factors or by electrophysiologic properties of the accessory pathway or ventricles. Accessory pathway conduction was completely or partially eliminated by ablation procedures in 14 of 20 @entity0 . During a mean follow-up of 27 months, @entity3 recurred in two @entity0 with failed ablation procedures and in one @entity0 with @entity7 (despite accessory pathway division) (p = 0.019 vs pre-ablation). @entity2 remained inducible in two @entity0 in whom accessory pathway ablation failed (p = 0.01 vs initial study). However, spontaneous @entity4 did not occur during follow-up. We conclude that susceptibility to spontaneous or inducible @entity3 and @entity4 in @entity0 with @entity6 and no @entity1 depends primarily on the existence of a functional accessory pathway. These susceptibilities are eliminated by interruption of accessory pathway conduction. @entity4 remain infrequent spontaneous events in the @entity6 . Their more frequent induction at electrophysiologic study is not predictive of clinical occurrence.

title: Susceptibility to @entity3 and XXXX in the @entity6 : role of the accessory pathway.

answer: @entity4


abstract: Clinical and electrophysiologic characteristics associated with spontaneous and inducible @entity3 and @entity4 were assessed in 20 consecutive @entity0 with @entity6 undergoing surgical division (n = 12) or transcatheter electrical ablation (n = 8) of accessory pathways. @entity0 with spontaneous @entity3 were characterized by the trend (not significant) of a shorter antegrade accessory pathway effective refractory period (256 +/- 26 vs 303 +/- 109 msec). However, @entity0 with and without spontaneous @entity3 did not differ with respect to prevalence of structural @entity1 (3 of 11 vs 2 of 9), intra-atrial conduction time (34 +/- 10 vs 32 +/- 10 msec), or interatrial conduction time (86 +/- 21 vs 88 +/- 17 msec). Thus, atrial and accessory pathway electrophysiologic properties (per se) were not clear determinants of susceptibility to @entity3 . Among the 20 @entity0 , 10 to 35 beats of nonsustained @entity4 (seven @entity0 ) or @entity5 (three @entity0 ) were induced at electrophysiologic study with one to three programmed extrastimuli. Clinically, a @entity2 ( @entity5 during @entity3 ) had occurred in only one of these @entity0 . The discordance of these observations was significant (p less than 0.01). @entity0 with and without inducible @entity2 were not distinguished by clinical factors or by electrophysiologic properties of the accessory pathway or ventricles. Accessory pathway conduction was completely or partially eliminated by ablation procedures in 14 of 20 @entity0 . During a mean follow-up of 27 months, @entity3 recurred in two @entity0 with failed ablation procedures and in one @entity0 with @entity7 (despite accessory pathway division) (p = 0.019 vs pre-ablation). @entity2 remained inducible in two @entity0 in whom accessory pathway ablation failed (p = 0.01 vs initial study). However, spontaneous @entity4 did not occur during follow-up. We conclude that susceptibility to spontaneous or inducible @entity3 and @entity4 in @entity0 with @entity6 and no @entity1 depends primarily on the existence of a functional accessory pathway. These susceptibilities are eliminated by interruption of accessory pathway conduction. @entity4 remain infrequent spontaneous events in the @entity6 . Their more frequent induction at electrophysiologic study is not predictive of clinical occurrence.

title: Susceptibility to XXXX and @entity4 in the @entity6 : role of the accessory pathway.

answer: @entity3


abstract: Cardiac @entity1 are often clinically inapparent but have important prognostic significance. A total of 1046 consecutive autopsies performed between 1981 and 1983 were reviewed, and 210 @entity0 with both premortem and autopsy diagnoses of @entity2 were found, in whom a recent (less than 3 months before death) ECG was available. Of these @entity0 , 47 had cardiac @entity1 (group I) and 163 did not (group II). In group I, 19 @entity0 had new ECG changes suggestive of @entity6 or injury, including either diffuse T wave inversion (10%), segmental (ECG pattern suggestive of a specific coronary distribution) T wave inversion (80%), or ST elevation (10%). None of these @entity0 had symptoms suggestive of @entity6 . In group II, six @entity0 had ECG changes suggestive of @entity6 or injury: four @entity0 with @entity4 , one with @entity5 , and one with aspergillus nodules within the myocardium. New @entity7 (seven @entity0 ) and low voltage (10 @entity0 ) were found with greater frequency in group I @entity0 (p less than 0.0005 and p less than 0.00001, respectively, vs group II). @entity0 with normal ECGs were unlikely to have cardiac @entity1 ; however, the finding of nonspecific ST-T wave changes was not helpful in differentiating the two groups. In clinically stable @entity0 with @entity2 and no cardiac symptoms suggestive of @entity3 , any new ECG change should raise the suspicion of cardiac @entity1 . The ECG finding of @entity6 or injury has high specificity (96%, p less than 0.000001) for cardiac @entity1 .

title: Electrocardiographic markers of cardiac XXXX .

answer: @entity1


abstract: Transcriptional regulation of ribosome and tRNA synthesis plays a central role in determining protein synthetic capacity and is tightly controlled in response to nutrient availability and cellular stress. In @entity0 , the regulation of ribosome and tRNA synthesis was recently shown to involve the Cdc-like kinase @entity3 and the GSK-3 kinase Mck1. In this study, we explored additional roles for these conserved kinases in processes connected to the target of @entity1 complex 1 (TORC1). We conducted a synthetic chemical-genetic screen in a @entity3   mck1   strain and identified many novel @entity1 -hypersensitive genes. Gene ontology analysis showed enrichment for TORC1-regulated processes (vesicle-mediated transport, autophagy, and regulation of cell size) and identified new connections to protein complexes including the protein kinase CK2. CK2 is considered to be a constitutively active kinase and in budding @entity0 , the holoenzyme comprises two regulatory subunits, @entity4 and @entity5 , and two catalytic subunits, @entity6 and @entity2 . We show that @entity4 is differentially phosphorylated in vivo and that @entity3 mediates this phosphorylation when nutrients are limiting and under all tested stress conditions. We determined that the phosphorylation of @entity4 does not detectably affect the stability of the CK2 holoenzyme but correlates with the reduced occupancy of @entity4 on tRNA genes after @entity1 treatment. Thus, the differential occupancy of tRNA genes by CK2 is likely to modulate its activation of RNA polymerase III transcription. Our data suggest that TORC1, via its effector kinase @entity3 , may regulate the association of CK2 with some of its substrates by phosphorylating @entity4 .

title: Differential Phosphorylation of a Regulatory Subunit of Protein Kinase CK2 by Target of XXXX Complex 1 Signaling and the Cdc-like Kinase @entity3 .

answer: @entity1


abstract: Transcriptional regulation of ribosome and tRNA synthesis plays a central role in determining protein synthetic capacity and is tightly controlled in response to nutrient availability and cellular stress. In @entity0 , the regulation of ribosome and tRNA synthesis was recently shown to involve the Cdc-like kinase @entity3 and the GSK-3 kinase Mck1. In this study, we explored additional roles for these conserved kinases in processes connected to the target of @entity1 complex 1 (TORC1). We conducted a synthetic chemical-genetic screen in a @entity3   mck1   strain and identified many novel @entity1 -hypersensitive genes. Gene ontology analysis showed enrichment for TORC1-regulated processes (vesicle-mediated transport, autophagy, and regulation of cell size) and identified new connections to protein complexes including the protein kinase CK2. CK2 is considered to be a constitutively active kinase and in budding @entity0 , the holoenzyme comprises two regulatory subunits, @entity4 and @entity5 , and two catalytic subunits, @entity6 and @entity2 . We show that @entity4 is differentially phosphorylated in vivo and that @entity3 mediates this phosphorylation when nutrients are limiting and under all tested stress conditions. We determined that the phosphorylation of @entity4 does not detectably affect the stability of the CK2 holoenzyme but correlates with the reduced occupancy of @entity4 on tRNA genes after @entity1 treatment. Thus, the differential occupancy of tRNA genes by CK2 is likely to modulate its activation of RNA polymerase III transcription. Our data suggest that TORC1, via its effector kinase @entity3 , may regulate the association of CK2 with some of its substrates by phosphorylating @entity4 .

title: Differential Phosphorylation of a Regulatory Subunit of Protein Kinase CK2 by Target of @entity1 Complex 1 Signaling and the Cdc-like Kinase XXXX .

answer: @entity3


abstract: The cytogenesis of @entity2 ( @entity1 ) was assessed by immunohistochemical methods. Three @entity1 were analyzed by a sensitive immunoalkaline phosphatase technique with a panel of monoclonal antibodies, including eight reacting with separate antigens previously found to be present on mononuclear phagocytes (MPs) and one specific for the endothelial marker, coagulation Factor 8. Among the MP-associated antigens evaluated were leukocyte common antigen (LCA), HLA-DR, C3b receptor, and C3bi receptor. Also incorporated in the panel were antibodies to MP-associated antigens with well-characterized tissue distribution but of currently unknown function. Constituent cells of the @entity0 varied in their reactions with the antibodies of the panel. Although mononuclear cells in @entity0 stroma were labeled with all of the antibodies against the MP markers, giant cells reacted strongly only with antibodies to LCA and the MP-associated antigen recognized by the antibody EBM11. Giant cells were weakly and focally labeled with antibodies (KB90 and UCHM1) against two additional MP-associated determinants and were unreactive with the remaining antibodies in the panel. Spindled stromal cells, which appeared to produce collagen, were not labeled with any of the antibodies in the panel. Only endothelial cells reacted with antibody to Factor 8. The results of this study suggest that giant cells of @entity1 are derived from stromal cells of mononuclear phagocyte lineage, and that the stromal precurser cells lose some, but not all, MP-associated antigens as they mature into giant cells.

title: Immunohistochemical study of mononuclear phagocyte antigens in XXXX .

answer: @entity2


abstract: The abdominal viscera of @entity0 have been postulated to contain a site of cardiovascular regulation. In particular, a baroreceptive function has been ascribed to splanchnic afferent nerves. We wished to determine whether afferents with a cardiac-rhythmic discharge functioned as arterial baroreceptors. Nineteen afferents with a cardiac rhythmic discharge were studied. All afferents were A fibers, whose endings were located in either the pancreas, mesentery, or porta hepatis region. We examined their characteristics of discharge with regard to changes in mean pressure, pulse pressure, and dP/dt of the arterial pulse. Hemodynamic alterations were achieved by intravenous administration of @entity3 , @entity1 , or @entity2 and by occlusion of the descending thoracic aorta. After @entity3 , increases in nerve activity occurred when pulse pressure and dP/dt were increased but while mean pressure was decreasing, indicating that mean pressure was not the stimulus for discharge of these afferents. Additionally, under similar hemodynamic conditions, afferents did not demonstrate reproducible patterns of activity. The afferents generally discharged with one impulse per cardiac cycle, rarely with two to three impulses per cycle. None demonstrated a bursting pattern even when arterial blood pressure was quite elevated. The spontaneous pattern of discharge changed frequently, often after the viscera were repositioned, and sometimes remained even after complete occlusion of the aorta. The data indicate that these visceral afferents do not respond as high pressure, arterial baroreceptors. All afferents adapted extremely rapidly and exhibited a low gain (0.02 +/- 0.00 impulses X s-1 X mmHg-1), indicating that these fibers would be ineffective in signaling physiologically significant changes in hemodynamic variables. The data from this study do not support the existence of baroreceptors in the abdominal viscera of @entity0 .

title: Evidence against high pressure, arterial baroreceptors in the abdominal viscera of XXXX .

answer: @entity0


abstract: The @entity4 antagonist @entity6 (Adalat) was administered to 60 @entity0 with essential @entity2 and investigations were performed on acute and chronic @entity5 effects. The following results were obtained: 1. Acute @entity5 effects: @entity6 (20 mg) was either orally or sublingually administered. Following oral administration, significant @entity5 effect was attained 20 min after administration and the maximum @entity5 response was obtained 2-4 h after administration. In cases of sublingual administration, significant @entity5 effect was notable 5 min after administration and blood pressure reached the lowest level 2-3 h after administration. The @entity5 effects lasted for a relatively longer period and significantly lower blood pressure than the control level was observed even 3 h after administration. 2. @entity5 effects: @entity6 (30-60 mg/d) was orally administered consecutively. Significant @entity5 effect was attained in and after the 4th week of administration. The yearly changes in the long-term administration cases over 3 years demonstrated significant @entity5 effects. The cases who did not respond to single administration of @entity8 or beta-blockers exhibited significant @entity5 response by the combined use of @entity6 . 3. Change in heart rate: In the acute study, heart rate increased after @entity6 administration and lasted for several hours. In the long-term administration cases, the changes in heart rate were not significant. 4. Side effects attributable to @entity6 such as @entity1 in 2 cases, @entity7 , warm sensation and @entity3 in 1 case each were observed early after the administration but there were no cases in whom administration was discontinued due to these side effects.

title: Antihypertensive effects of the @entity4 antagonistic agent XXXX .

answer: @entity6


abstract: The @entity4 antagonist @entity6 (Adalat) was administered to 60 @entity0 with essential @entity2 and investigations were performed on acute and chronic @entity5 effects. The following results were obtained: 1. Acute @entity5 effects: @entity6 (20 mg) was either orally or sublingually administered. Following oral administration, significant @entity5 effect was attained 20 min after administration and the maximum @entity5 response was obtained 2-4 h after administration. In cases of sublingual administration, significant @entity5 effect was notable 5 min after administration and blood pressure reached the lowest level 2-3 h after administration. The @entity5 effects lasted for a relatively longer period and significantly lower blood pressure than the control level was observed even 3 h after administration. 2. @entity5 effects: @entity6 (30-60 mg/d) was orally administered consecutively. Significant @entity5 effect was attained in and after the 4th week of administration. The yearly changes in the long-term administration cases over 3 years demonstrated significant @entity5 effects. The cases who did not respond to single administration of @entity8 or beta-blockers exhibited significant @entity5 response by the combined use of @entity6 . 3. Change in heart rate: In the acute study, heart rate increased after @entity6 administration and lasted for several hours. In the long-term administration cases, the changes in heart rate were not significant. 4. Side effects attributable to @entity6 such as @entity1 in 2 cases, @entity7 , warm sensation and @entity3 in 1 case each were observed early after the administration but there were no cases in whom administration was discontinued due to these side effects.

title: Antihypertensive effects of the XXXX antagonistic agent @entity6 .

answer: @entity4


abstract: UNASSIGNED: This study examined the relationship among baseline program and teacher characteristics and subsequent implementation of Banking Time. Banking Time is a dyadic intervention intended to improve a teacher's interaction quality with a specific @entity0 . Banking Time implementation was examined in the current study using a sample of 59 teachers and preschool @entity0 displaying @entity1 in the classroom (~three @entity0 per classroom). Predictors included preschool program type, teacher demographic characteristics (personal and professional), and teacher beliefs (self-efficacy, authoritarian beliefs, and negative attributions about @entity0 disruptive behavior). Multiple measures and methods (i.e., teacher report, consultant report, independent observations) were used to assess implementation. We created three implementation composite measures (dosage, quality, and generalized practice) that had high internal consistencies within each composite but were only modestly associated with one another, suggesting unique constructs of implementation. We found that type of preschool program was associated with dosage and quality. Aspects of teacher demographics related to all three implementation composites. Teacher beliefs predicted dosage and generalized practice. Results suggest that the factors that predict the implementation of Banking Time vary as a function of the type of implementation being assessed.

title: Program and Teacher Characteristics Predicting the Implementation of Banking Time with Preschoolers Who Display XXXX .

answer: @entity1


abstract: Epidemiologic studies support an association among elevated levels of @entity3 ( @entity2 ), increased respiratory symptoms, and alterations in lung function. To determine if low level @entity2 inhalation potentiates exercise-induced @entity1 , 15 @entity0 subjects, defined by airway constriction with cold air provocation, inhaled 0.30 ppm (560 micrograms/m3) @entity2 for 30 min. All asthmatics inhaled either air or 0.30 ppm @entity2 via a mouthpiece for 20 min at rest followed by 10 min of exercise on a bicycle ergometer at a workload of 300 kpm/min, producing a 3-fold or greater increase in minute ventilation. Our studies @entity4 (SE)% deposition of inhaled @entity2 at rest and 87 +/- 1% deposition with exercise (p less than 0.001). @entity3 inhalation at rest resulted in no significant change in pulmonary function. @entity3 inhalation plus exercise compared to control (air) exposure plus exercise produced significantly greater reductions in FEV (p less than 0.01) and partial expiratory flow rates at 60% of total lung capacity (p less than 0.05). One hour after completion of @entity2 exposure and exercise, pulmonary function had returned to baseline values. To determine if @entity2 exposure caused increased reactivity to a known bronchoconstrictor, @entity0 subjects inhaled cold air (range: -11 +/- 2 degrees C) at 3 successive rates of isocapnic ventilation. The response to cold air was expressed as the respiratory heat exchange required to reduce the FEV by 10% (PD10RHE). Prior @entity2 exposure potentiated the fall in FEV, PD10RHE, and specific airway conductance (p less than 0.05) after isocapnic cold air hyperventilation, compared to the control exposure.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Inhalation of 0.30 ppm XXXX potentiates exercise-induced @entity1 in asthmatics.

answer: @entity3


abstract: Epidemiologic studies support an association among elevated levels of @entity3 ( @entity2 ), increased respiratory symptoms, and alterations in lung function. To determine if low level @entity2 inhalation potentiates exercise-induced @entity1 , 15 @entity0 subjects, defined by airway constriction with cold air provocation, inhaled 0.30 ppm (560 micrograms/m3) @entity2 for 30 min. All asthmatics inhaled either air or 0.30 ppm @entity2 via a mouthpiece for 20 min at rest followed by 10 min of exercise on a bicycle ergometer at a workload of 300 kpm/min, producing a 3-fold or greater increase in minute ventilation. Our studies @entity4 (SE)% deposition of inhaled @entity2 at rest and 87 +/- 1% deposition with exercise (p less than 0.001). @entity3 inhalation at rest resulted in no significant change in pulmonary function. @entity3 inhalation plus exercise compared to control (air) exposure plus exercise produced significantly greater reductions in FEV (p less than 0.01) and partial expiratory flow rates at 60% of total lung capacity (p less than 0.05). One hour after completion of @entity2 exposure and exercise, pulmonary function had returned to baseline values. To determine if @entity2 exposure caused increased reactivity to a known bronchoconstrictor, @entity0 subjects inhaled cold air (range: -11 +/- 2 degrees C) at 3 successive rates of isocapnic ventilation. The response to cold air was expressed as the respiratory heat exchange required to reduce the FEV by 10% (PD10RHE). Prior @entity2 exposure potentiated the fall in FEV, PD10RHE, and specific airway conductance (p less than 0.05) after isocapnic cold air hyperventilation, compared to the control exposure.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Inhalation of 0.30 ppm @entity3 potentiates exercise-induced XXXX in asthmatics.

answer: @entity1


abstract: The collateral circulation in the @entity0 small intestine was studied by evaluating the viability of an intestinal segment after its primary mesenteric vascular supply had been interrupted. After ligation of the main mesenteric branches of a 30-cm segment of either jejunum or ileum, viability was assessed immediately by the fluorescence pattern observed under ultraviolet illumination after the peripheral intravenous injection of @entity1 . Viability was assessed again at 48 hours by the @entity1 technique and by gross and histologic examination. With the marginal vessels intact, the collateral circulation was able to sustain 10 per cent of the entire length of small intestine beyond the point of devascularization. On the other hand, when the marginal vessels had been ligated, this length of sustained intestine proved to be negligible. With respect to the above findings, there was no difference in the extent or pattern of collateral circulation at different levels along the small intestine, from proximal jejunum to jejuno-ileal junction to terminal ileum. Systemic infusion of a vasodilator, @entity2 , was found to substantially decrease the length of small intestine maintained viable by collateral flow. This was associated with a greater decrease in systemic vascular resistance than in mesenteric vascular resistance, which resulted in a drop in mesenteric blood flow. In each of the above studies, the ultimate viability of the intestine by histologic section at 48 hours correlated closely with the @entity1 pattern immediately after devascularization. These studies demonstrate that the collateral circulation of the small intestine is extensive and sufficient to maintain viability in a substantial proportion of the length of the entire intestine.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effect of collateral circulation on intestinal viability following segmental devascularization in the XXXX .

answer: @entity0


abstract: OBJECTIVE Manual surveillance of healthcare-associated @entity1 is cumbersome and vulnerable to subjective interpretation. Automated systems are under development to improve efficiency and reliability of surveillance, for example by selecting high-risk @entity0 requiring manual chart review. In this study, we aimed to validate a previously developed multivariable prediction modeling approach for detecting @entity2 ( @entity2 ) in neurosurgical @entity0 and to assess its merits compared to conventional methods of automated surveillance. METHODS Prospective cohort study in 3 hospitals assessing the accuracy and efficiency of 2 automated surveillance methods for detecting @entity2 , the multivariable prediction model and a classification algorithm, using manual chart review as the reference standard. All 3 methods of surveillance were performed independently. @entity0 receiving cerebrospinal fluid drains were included (2012-2013), except @entity0 , and @entity0 deceased within 24 hours or with pre-existing @entity2 . Data required by automated surveillance methods were extracted from routine care clinical data warehouses. RESULTS In total, @entity2 occurred in 37 of 366 external cerebrospinal fluid drainage episodes (12.3/1000 drain days at risk). The multivariable prediction model had good discriminatory power (area under the ROC curve 0.91-1.00 by hospital), had adequate overall calibration, and could identify high-risk @entity0 requiring manual confirmation with 97.3% sensitivity and 52.2% positive predictive value, decreasing the workload for manual surveillance by 81%. The multivariable approach was more efficient than classification algorithms in 2 of 3 hospitals. CONCLUSIONS Automated surveillance of @entity2 using a multivariable prediction model in multiple hospitals considerably reduced the burden for manual chart review at near-perfect sensitivity. Infect Control Hosp Epidemiol 2015;36(1): 65-75.

title: Validation of an automated surveillance approach for XXXX : a multicenter study.

answer: @entity2


abstract: UNASSIGNED: The @entity1 peptide receptors (FPRs) are a family of chemoattractant receptors with important roles in host defense and the regulation of inflammatory reactions. In @entity0 , three FPR paralogs have been identified ( @entity3 , @entity5 , and @entity4 ) and may have functionally diversified by gene duplication and adaptive evolution. However, the evolutionary mechanisms operating in the diversification of FPR family genes and the changes in selection pressures have not been characterized to date. Here, we have made a comprehensive evolutionary analysis of FPR genes from @entity0 species. Phylogenetic analysis showed that an early duplication was responsible for @entity3 and @entity5 / @entity4 splitting, and @entity4 originated from the latest duplication event near the origin of primates. Codon-based tests of positive selection reveal interesting patterns in @entity3 and @entity5 versus @entity4 , with the first two genes showing clear evidence of positive selection at some sites while the majority of them evolve under strong negative selection. In contrast, our results suggest that the selective pressure may be relaxed in the @entity4 lineage. Of the six @entity2 sites inferred to evolve under positive selection in @entity3 and @entity5 , four sites were located in extracellular loops of the protein. The electrostatic potential of the extracellular surface of FPR might be affected more frequently with @entity2 substitutions in positively selected sites. Thus, positive selection of FPRs among mammals may reflect a link between changes in the sequence and surface structure of the proteins and is likely to be important in the host's defense against invading pathogens.

title: Adaptive Evolution of XXXX Peptide Receptors in Mammals.

answer: @entity1


abstract: Temporary and immediately usable vascular access is a vital need in treating @entity6 @entity0 . Subclavian vein cannulation, although a major progress, has been associated with significant morbidity and mortality. Accordingly, for the last 2.5 years the authors have been developing an alternative technique consisting of internal jugular vein cannulation (IJVC) with two @entity5 rubber catheters with a long-term, proved biocompatibility. One hundred sixty-five pairs of cannulas were inserted in 153 @entity0 . Mean duration of use was 57 days (1 day to 17 months). More than 3,000 high-performance hemodialysis sessions were performed. IJVC handling and care were easily managed by nurses. A low incidence of complications was observed: two @entity4 episodes, four @entity2 with three @entity3 , one @entity7 , and one anaphylactoid reaction. No @entity1 was related to the technique itself. IJVC offers a new, safe, and reliable temporary vascular access immediately usable for all kinds of extracorporeal treatment.

title: Internal jugular vein cannulation with two XXXX rubber catheters: a new and safe temporary vascular access for hemodialysis. Thirty months' experience.

answer: @entity5


abstract: The presented case displays a clinical study of a @entity1 phenotype with a poor clinical outcome. Prediction of @entity1 development and effects of treatment at the beginning of the clinical stage is difficult as the knowledge of @entity1 process and all necessary parameters of the host body are limited. @entity1 is mainly studied on the basis of biochemical-genetic processes and their morphological manifestation. However, the malignant process is assumed to be of essential biophysical nature and develops after @entity3 , which is a direct result of oncogene mutation. @entity1 based on the normal and the reverse Warburg effect should be distinguished. The @entity1 with the reverse Warburg effect display @entity2 associated with a high rate of recurrence and metastatic implantation. Besides the nature of the two basic types of @entity0 the outcome depends not only on their type, size, and site but also on reactions and interaction with the surrounding tissue and the body aptitude for metastatic activity connected with individual blood or lymphatic vessels for metastatic transport. It is necessary to assess all favourable and adverse factors for @entity1 development. General reliable method of their specification for all @entity1 is not available. Nevertheless, the main factor seems to be @entity2 of @entity1 cells as follows from interpretation. To reveal the aggressive reverse @entity1 , metabolic biomarkers of the fibroblast stress should be examined.

title: Is the small size of a XXXX the crucial point for successful medical treatment?

answer: @entity0


abstract: Sixty-two @entity0 with 67 large or poorly defined @entity4 predominantly on the head and neck (58 @entity5 ) were treated by excision of the lesion and allowing the defect created to heal by second intention. Histological control of the adequacy of excision was monitored using routine vertical sections of @entity2 -fixed tissue. Further re-excisions were performed in 17 @entity0 in whom @entity1 extended up to or within 1 high power field (approximately 0.44 mm) of the excision margin. The @entity2 -fixed specimens ranged from 6-60 (mean 21) mm in diameter and 2-12 (mean 5) mm in depth. After one excision the time to complete re-epithelialization was directly proportional to the surface area (r = 0.73) and ranged from 13 to 60 days (mean 33 days). Measurements of the movements of fixed reference points tattooed at the wound edges in six @entity0 showed that movement of surrounding tissue into the defect accounted for 39-62% (mean 45%) of the reduction in surface area of the defect during healing. @entity3 were rare and the cosmetic results were considered good or excellent in 48 @entity0 , fair in nine and poor, i.e. requiring corrective surgery, in three @entity0 . Poor results were due to distortions of free margins, e.g. lower eyelid and nasal margin. The major benefit of this technique is the ease with which further excisions can be performed when histologically indicated.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Excision of XXXX without wound closure.

answer: @entity4


abstract: UNASSIGNED: L-3,4-dihydroxyphenylalanine (L-DOPA) reduces symptoms of @entity1 ( @entity1 ), but suffers from serious side effects on long-term use. Melatonin (10-30  mg/kg, 6  doses at 10  hr intervals) was investigated to potentiate L-DOPA therapeutic effects in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced @entity2 in @entity0 . Striatal tyrosine hydroxylase (TH) immunoreactivity, TH, and phosphorylated ser 40 TH (p-TH) protein levels were assayed on 7th day. Nigral TH-positive neurons stereology was conducted on serial sections 2.8  mm from bregma rostrally to 3.74  mm caudally. MPTP caused 39% and 58% decrease, respectively, in striatal fibers and TH protein levels, but 2.5-fold increase in p-TH levels. About 35% TH neurons were lost between 360 and 600   m from 940   m of the entire nigra analyzed, but no neurons were lost between 250   m rostrally and 220   m caudally. When L-DOPA in small doses (5-8  mg/kg) failed to affect MPTP-induced @entity3 or @entity4 , co-administration of melatonin with L-DOPA attenuated these behaviors. Melatonin administration significantly attenuated MPTP-induced loss in striatal TH fibers (82%), TH (62%) and p-TH protein (100%) levels, and nigral neurons (87-100%). Melatonin failed to attenuate MPTP-induced striatal dopamine depletion. L-DOPA administration (5  mg/kg, once 40  min prior to sacrifice, p.o.) in MPTP- and melatonin-treated @entity0 caused significant increase in striatal dopamine (31%), as compared to L-DOPA and MPTP-treated @entity0 . This was equivalent to 8  mg/kg L-DOPA administration in @entity1 @entity0 . Therefore, prolonged, effective use of L-DOPA in @entity1 with lesser side effects could be achieved by treating with 60% lower doses of L-DOPA along with melatonin.

title: Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced XXXX in @entity0 .

answer: @entity2


abstract: UNASSIGNED: L-3,4-dihydroxyphenylalanine (L-DOPA) reduces symptoms of @entity1 ( @entity1 ), but suffers from serious side effects on long-term use. Melatonin (10-30  mg/kg, 6  doses at 10  hr intervals) was investigated to potentiate L-DOPA therapeutic effects in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced @entity2 in @entity0 . Striatal tyrosine hydroxylase (TH) immunoreactivity, TH, and phosphorylated ser 40 TH (p-TH) protein levels were assayed on 7th day. Nigral TH-positive neurons stereology was conducted on serial sections 2.8  mm from bregma rostrally to 3.74  mm caudally. MPTP caused 39% and 58% decrease, respectively, in striatal fibers and TH protein levels, but 2.5-fold increase in p-TH levels. About 35% TH neurons were lost between 360 and 600   m from 940   m of the entire nigra analyzed, but no neurons were lost between 250   m rostrally and 220   m caudally. When L-DOPA in small doses (5-8  mg/kg) failed to affect MPTP-induced @entity3 or @entity4 , co-administration of melatonin with L-DOPA attenuated these behaviors. Melatonin administration significantly attenuated MPTP-induced loss in striatal TH fibers (82%), TH (62%) and p-TH protein (100%) levels, and nigral neurons (87-100%). Melatonin failed to attenuate MPTP-induced striatal dopamine depletion. L-DOPA administration (5  mg/kg, once 40  min prior to sacrifice, p.o.) in MPTP- and melatonin-treated @entity0 caused significant increase in striatal dopamine (31%), as compared to L-DOPA and MPTP-treated @entity0 . This was equivalent to 8  mg/kg L-DOPA administration in @entity1 @entity0 . Therefore, prolonged, effective use of L-DOPA in @entity1 with lesser side effects could be achieved by treating with 60% lower doses of L-DOPA along with melatonin.

title: Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced @entity2 in XXXX .

answer: @entity0


abstract: Two alternative procedures for the isolation of the @entity6 from @entity4 were compared and the properties of a specifically nicked EF-Tu . @entity2 were examined in detail. Although the native elongation factor possessed similar catalytic activities in all reactions investigated as the protein isolated by Arai et al. [Eur. J. Biochem. 92, 509-519 and 521-531 (1978)] it could not be crystallized. The nicked EF-Tu, consisting of two associated fragments with molecular weights of 41000 and 8000 respectively, was active in binding @entity2 , @entity3 and in the formation of @entity1 -tRNAPhe . EF-Tu . @entity3 ternary complex. However, it did not promote poly(U)-dependent synthesis of @entity5 on @entity0 ribosomes. The isolated fragment of a molecular weight of about 41000 did not bind @entity2 . This activity could be reconstituted with the supplement of the small 8000-Mr fragment. It is demonstrated that, in contrast to the native EF-Tu, the nicked EF-Tu forms high-molecular-weight aggregates. Cleavage of the polypeptide chain of EF-Tu from @entity4 stimulates the crystallization of this protein.

title: Properties of native and nicked XXXX from Thermus thermophilus HB 8.

answer: @entity6


abstract: Between 1966 and 1979 60 @entity0 underwent resection of @entity4 at the National Heart Hospital. There was a male:female ratio of 40:20 and an age range of 4 to 56 years (mean 18 years). 22 @entity0 (36.7%) had a single or multiple additional @entity1 including left @entity16 (12 cases), right @entity16 (3 cases), @entity13 (6 cases), @entity14 (5 cases), @entity12 (1 case), @entity17 (1 case) and mitral @entity11 associated with a single ventricle (1 case). Isolated resection of the organic sub-aortic with myotomy and wedge resection was performed in 47 @entity0 and Cooley technique in 2 @entity0 . Total aortic root replacement with a homograft valve was necessary in 4 @entity0 and the 22 @entity0 additional @entity1 received concomitant surgery. There was one early death (2.6%) amongst the 38 @entity0 with isolated organic sub-aortic @entity8 and no late deaths. There were 3 early deaths (13.7%) amongst the 22 @entity0 with additional @entity1 and one late @entity10 after 14 months. There were 7 non-fatal complications: a @entity5 , @entity6 and pacemaker insertion; three mild @entity2 ; one mild @entity3 ; an @entity9 due to @entity15 ; and an aortic and mitral valve replacement after 9 years. 43 other @entity0 have been followed for 1 to 14 years and are symptom free. @entity7 is present in two of them. Resection of organic sub-aortic @entity8 with myotomy and wedge resection is a safe technique and offers an excellent prognosis for this group of congenitally compromised @entity0 .

title: [Organic subaortic XXXX . Surgical indications, surgical technic, late results].

answer: @entity8


abstract: A surface-active material with a chemical composition consistent with lung surfactant and with the ability to lower surface tension on a Wilhelmy balance to about 6 mN/m, has been isolated from @entity0 pulmonary lavage. The thermotropic properties have been characterized with the techniques of Fourier transform infrared spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC). FT-IR melting curves were constructed from the temperature-dependence of the lipid @entity2 symmetric stretching vibrational frequencies near 2850 cm-1. A broad gel-liquid crystal phase transition with an onset temperature of about 22 degrees C, and a completion temperature of about 38 degrees C was observed, with slight sample-to-sample variations in temperatures. A similar completion temperature was noted in DSC endotherms. @entity1 (5-10 mM) increased the onset temperature of the lipid-melting event, and induced an ordering of surfactant and of its lipid extract at all temperatures studied. The effect on the lipids was suggestive of a @entity1 -induced phase separation caused by ion binding to @entity4 and other acidic components. Evidence for a direct interaction between @entity1 and the @entity3 groups was suggested through small @entity1 -induced shifts in the 1090 cm-1 symmetric @entity5 stretching frequency. Removal of most of the protein component from a 10:1 (lipid/protein, w/w) sample caused an ordering of the resultant lipid fractions. In contrast, removal of most of the protein component from a 20:1 sample resulted in no change in lipid order or thermotropic behavior. These observations are discussed in light of the roles played both by @entity1 and protein in the spreading of surfactant. The power of FT-IR to acquire useful structural information from complex biological tissues is demonstrated.

title: Fourier transform infrared and differential scanning calorimetric studies of a surface-active material from XXXX lung.

answer: @entity0


abstract: UNASSIGNED: Background The West African outbreak of @entity3 that peaked in 2014 has caused more than 11,000 @entity1 . The development of an effective Ebola vaccine is a priority for control of a future outbreak. Methods In this phase 1 study, we administered a single dose of the @entity2 adenovirus 3 (ChAd3) vaccine encoding the surface glycoprotein of @entity5 ( @entity5 ) to 60 healthy adult volunteers in Oxford, United Kingdom. The vaccine was administered in three dose levels - 1*10(10) viral particles, 2.5*10(10) viral particles, and 5*10(10) viral particles - with 20 @entity0 in each group. We then assessed the effect of adding a booster dose of a modified vaccinia Ankara (MVA) strain, encoding the same Ebola virus glycoprotein, in 30 of the 60 @entity0 and evaluated a reduced prime-boost interval in another 16 @entity0 . We also compared antibody responses to inactivated whole Ebola virus virions and neutralizing antibody activity with those observed in phase 1 studies of a recombinant @entity4 virus-based vaccine expressing a @entity5 glycoprotein (rVSV- @entity5 ) to determine relative potency and assess durability. Results No safety concerns were identified at any of the dose levels studied. Four weeks after immunization with the ChAd3 vaccine, ZEBOV-specific antibody responses were similar to those induced by rVSV- @entity5 vaccination, with a geometric mean titer of 752 and 921, respectively. @entity5 neutralization activity was also similar with the two vaccines (geometric mean titer, 14.9 and 22.2, respectively). Boosting with the MVA vector increased virus-specific antibodies by a factor of 12 (geometric mean titer, 9007) and increased glycoprotein-specific CD8+ T cells by a factor of 5. Significant increases in neutralizing antibodies were seen after boosting in all 30 @entity0 (geometric mean titer, 139; P<0.001). Virus-specific antibody responses in @entity0 primed with ChAd3 remained positive 6 months after vaccination (geometric mean titer, 758) but were significantly higher in those who had received the MVA booster (geometric mean titer, 1750; P<0.001). Conclusions The ChAd3 vaccine boosted with MVA elicited B-cell and T-cell immune responses to @entity5 that were superior to those induced by the ChAd3 vaccine alone. (Funded by the Wellcome Trust and others; ClinicalTrials.gov number, NCT02240875 .).

title: A Monovalent XXXX Adenovirus Ebola Vaccine Boosted with MVA.

answer: @entity2


abstract: A clinicopathologic analysis of 35 cases of @entity2 ( @entity2 ) was performed, and the relationship between various histologic features and stage at presentation was examined. The series comprised 31 male and 4 female @entity0 with a median age of 32 years. Twenty @entity0 had Ann Arbor Stage I disease; 5, Stage II; 8, Stage III; and 2, Stage IV. Eight cases showed a multifocal epithelioid histiocytic reaction; six of these had @entity1 (P = 0.003). Five cases contained relatively frequent atypical mononuclear cells; four of these were Stage III or IV (P = 0.017). A purely diffuse growth pattern was also associated with high stage (P = 0.031). Presence of nodularity correlated with low stage (P = 0.031). During follow-up (median, 4 years; range, 2.5 months-18 years) there was a high incidence of second @entity1 (2 large cell lymphomas, 3 non-hematologic @entity1 ). @entity2 manifests greater diversity of stage at presentation than originally thought. A high content of epithelioid histiocytes, relatively frequent atypical mononuclear cells, and diffuse histology appear to define subsets associated with @entity1 . The correlation of nodular growth pattern with low-stage disease is consistent with the distinctive behavior and derivation of nodular @entity2 .

title: Lymphocyte predominance XXXX . A clinicopathologic reassessment.

answer: @entity2


abstract: UNASSIGNED: There is growing evidence about differences in metastatic spread among @entity0 ( @entity0 ) @entity3 ( @entity3 ). Aim of this study was to analyze the pattern of metastasization according to @entity3 and to explore the corresponding prognosis. A series of 544 consecutive patients receiving anticancer therapy for metastatic @entity0 from 2004 to 2013, was analyzed. @entity3 were defined by immunohistochemistry according to St Gallen 2013 criteria. Association between @entity3 and the different distant localizations was analyzed. Prognosis was described in terms of overall survival (OS), progression free survival (PFS) and @entity1 ( @entity1 ). Results were reported taking luminal A @entity0 as reference. Triple negative @entity0 showed a higher tropism for lung (OR 4.30 95  % CI 1.41-13.1), while non luminal @entity2 subtype was associated with a higher rate of liver metastases (OR 3.61 95  % CI 1.36-9.58). All subtypes were associated with a lower risk of bone-only localization. Central nervous system (CNS) involvement was more common in @entity2 positive @entity0 (OR 6.3, 95  % CI 1.08-36.66). Liver, lung and CNS involvement influenced negatively OS (HR 1.64, 95  % CI 1.29-2.07; HR 1.49, 95  % CI 1.18-1.90; HR 2.891, 95  % CI 1.85-4.51, respectively) and PFS (HR 1.39, 95  % CI 1.13-1.71; HR 1.26, 95  % CI 1.02-1.55; HR 1.75, 95  % CI 1.12-2.71, respectively). Multivariate analysis confirmed liver involvement as independent predictor of worse OS (HR 1.64, 95  % CI 1.15-2.34). Stratification by metastatic pattern showed significant differences in terms of @entity1 but not in terms of PFS. The study suggests that @entity3 may be characterized by typical patterns of metastatic spread and have different impact on clinical outcome.

title: Pattern of metastasis and outcome in patients with XXXX .

answer: @entity0


abstract: PURPOSE: This study evaluated 2  years of follow-up of the Ovation Abdominal Stent Graft System (TriVascular Inc., Santa Rosa, CA, USA) for endovascular repair (EVAR) of @entity3 ( @entity3 ). MATERIALS AND METHODS: This retrospective multicentre study included 36 @entity0 (median age, 73.6  year) with @entity3 (mean diameter, 5.65  cm) treated with the Ovation stent graft and followed up for at least 2  years. Safety and effectiveness of the Ovation stent graft were evaluated. Indications for EVAR were the following: AAA >= 5  cm, neck length >= 7  mm, angulation  <=60   and diameter <30  mm; the presence of neck calcification and @entity2 was not considered a contraindication; distal iliac landing zone length of 10  mm, and diameter between 5 and 20  mm. @entity0 were treated under a common protocol, including clinical and imaging follow-up at discharge, 30  days, 6  months, and annually for 5  years. Adverse events, clinical and imaging data and possible re-intervention were recorded. RESULTS: The Ovation stent graft was implanted successfully in 36 @entity0 (100  %). None of the @entity0 required conversion to open surgery, and none presented with an @entity5 . Endograft stent @entity1 or migration was not observed in any case. No type I, III or IV @entity4 were observed; in 12 @entity0 (33.3  %), a @entity4 was noted, in one case with sac enlargement but not treated due to concomitant comorbidities and the @entity0 's decision. CONCLUSIONS: The 2-year results of the Ovation Abdominal Stent Graft System demonstrate excellent safety and effectiveness in the treatment of @entity0 with @entity3 , particularly in those with challenging anatomical characteristics.

title: Ultra-low profile polymer-filled stent graft for XXXX treatment: a two-year follow-up.

answer: @entity3