abstract: BACKGROUND AND AIMS:: Several studies have demonstrated that @entity0 with essential @entity4 ( @entity6 ) may also have @entity1 ( @entity1 ), and cross-sectional and population-based studies have shown that @entity6 is associated with prevalent @entity3 . Different presentations of MCI are suggested to be associated with different pathologies. For example, @entity5 may be associated with @entity2 . Therefore, in this study, we explored whether the MCI subtype in @entity0 with @entity6 (MCI- @entity6 +) is different from the MCI subtype in @entity0 without @entity6 attending a memory outpatient clinic (MCI- @entity6 -). METHODS:: Using a case-control study design, cognitive status in MCI @entity0 with @entity6 and without @entity6 was assessed by neuropsychological testing. @entity0 with MCI were stratified into groups: amnestic and nonamnestic MCI, or single-domain and multidomain MCI. RESULTS:: Of the 93 @entity0 in the @entity6 + group and the 169 in the @entity6 - group, 45 (48.4%) and 94 (55.6%) @entity0 had MCI, respectively. The frequency of MCI subtypes between the 2 groups was different, such that 25 (55.6%) @entity0 had nonamnestic MCI in the @entity6 + group and 68 (72.3%) @entity0 had @entity5 in @entity6 - group (  =10.195, P=0.001). Compared with the MCI- @entity6 + group, @entity0 in the MCI- @entity6 - group showed more severe @entity1 . CONCLUSIONS:: @entity6 is associated with MCI, particularly the nonamnestic subtype. These results suggest that @entity1 in @entity0 with @entity6 may have a different pathogenesis from that of @entity2 .

title: Subtype of Mild @entity1 in Elderly @entity0 With XXXX .

answer: @entity4


abstract: BACKGROUND AND AIMS:: Several studies have demonstrated that @entity0 with essential @entity4 ( @entity6 ) may also have @entity1 ( @entity1 ), and cross-sectional and population-based studies have shown that @entity6 is associated with prevalent @entity3 . Different presentations of MCI are suggested to be associated with different pathologies. For example, @entity5 may be associated with @entity2 . Therefore, in this study, we explored whether the MCI subtype in @entity0 with @entity6 (MCI- @entity6 +) is different from the MCI subtype in @entity0 without @entity6 attending a memory outpatient clinic (MCI- @entity6 -). METHODS:: Using a case-control study design, cognitive status in MCI @entity0 with @entity6 and without @entity6 was assessed by neuropsychological testing. @entity0 with MCI were stratified into groups: amnestic and nonamnestic MCI, or single-domain and multidomain MCI. RESULTS:: Of the 93 @entity0 in the @entity6 + group and the 169 in the @entity6 - group, 45 (48.4%) and 94 (55.6%) @entity0 had MCI, respectively. The frequency of MCI subtypes between the 2 groups was different, such that 25 (55.6%) @entity0 had nonamnestic MCI in the @entity6 + group and 68 (72.3%) @entity0 had @entity5 in @entity6 - group (  =10.195, P=0.001). Compared with the MCI- @entity6 + group, @entity0 in the MCI- @entity6 - group showed more severe @entity1 . CONCLUSIONS:: @entity6 is associated with MCI, particularly the nonamnestic subtype. These results suggest that @entity1 in @entity0 with @entity6 may have a different pathogenesis from that of @entity2 .

title: Subtype of Mild XXXX in Elderly @entity0 With @entity4 .

answer: @entity1


abstract: BACKGROUND AND AIMS:: Several studies have demonstrated that @entity0 with essential @entity4 ( @entity6 ) may also have @entity1 ( @entity1 ), and cross-sectional and population-based studies have shown that @entity6 is associated with prevalent @entity3 . Different presentations of MCI are suggested to be associated with different pathologies. For example, @entity5 may be associated with @entity2 . Therefore, in this study, we explored whether the MCI subtype in @entity0 with @entity6 (MCI- @entity6 +) is different from the MCI subtype in @entity0 without @entity6 attending a memory outpatient clinic (MCI- @entity6 -). METHODS:: Using a case-control study design, cognitive status in MCI @entity0 with @entity6 and without @entity6 was assessed by neuropsychological testing. @entity0 with MCI were stratified into groups: amnestic and nonamnestic MCI, or single-domain and multidomain MCI. RESULTS:: Of the 93 @entity0 in the @entity6 + group and the 169 in the @entity6 - group, 45 (48.4%) and 94 (55.6%) @entity0 had MCI, respectively. The frequency of MCI subtypes between the 2 groups was different, such that 25 (55.6%) @entity0 had nonamnestic MCI in the @entity6 + group and 68 (72.3%) @entity0 had @entity5 in @entity6 - group (  =10.195, P=0.001). Compared with the MCI- @entity6 + group, @entity0 in the MCI- @entity6 - group showed more severe @entity1 . CONCLUSIONS:: @entity6 is associated with MCI, particularly the nonamnestic subtype. These results suggest that @entity1 in @entity0 with @entity6 may have a different pathogenesis from that of @entity2 .

title: Subtype of Mild @entity1 in Elderly XXXX With @entity4 .

answer: @entity0


abstract: BACKGROUND: @entity3 , which represents 90% of @entity2 , is one of the most lethal and aggressive @entity1 . Operative resection remains the only treatment providing prolonged survival, however, recurrence of @entity3 occurs in up to 80% of @entity0 with @entity2 within 2  years of a potential curative resection. There are few reports of @entity5 recurrence (primary second @entity1 ) in the remnant pancreas after pancreatectomy. CASE PRESENTATION: A 52-year-old @entity0 underwent a distal pancreatectomy for @entity2 in September 2004. Adjuvant chemotherapy was started after surgery and continued for 4  years. In March 2012, marked elevation of DUPAN-II was observed, followed by an irregular stenotic finding in the main duct. We performed an en bloc resection of the remnant pancreas in July 2012. Histologically, the @entity1 contained a second primary @entity5 with @entity4 . At follow-up 20  months after the second operation, the @entity0 was alive without recurrence. Fourteen cases of resectable @entity1 developing in the remnant pancreas after a pancreatectomy for @entity1 have been reported; a minority of these was identified as second @entity1 . Therefore, our @entity0 's primary second @entity1 is a rare event. CONCLUSION: The @entity0 is considered to have shown a rare, unique @entity2 recurrence. Persistent elevation of a @entity1 marker and extensive imaging led to proper diagnosis and treatment.

title: Resectable carcinoma developing in the remnant pancreas 7  years and 10  months after distal pancreatectomy for XXXX : report of a case.

answer: @entity3


abstract: PURPOSE: To investigate whether the prophylactic use of bevacizumab reduces the rate of rubeosis after proton therapy for @entity5 and improves the possibility to treat @entity2 , reapplicated retina with laser photocoagulation. DESIGN: Comparative retrospective case series. METHODS: @entity5 @entity0 with @entity4 and treated with proton therapy were included in this institutional study. Twenty-four eyes received prophylactic intravitreal bevacizumab injections and were compared with a control group of 44 eyes without bevacizumab treatment. Bevacizumab injections were performed at the time of @entity7 clip insertion and were repeated every 2 months during 6 months, and every 3 months thereafter. Ultra-widefield angiography allowed determination of the extent of @entity6 , which was treated with laser photocoagulation after retinal reapplication. Main outcome measures were the time to rubeosis, the time to retinal reattachment, and the time to laser photocoagulation of @entity2 retina. RESULTS: Baseline characteristics were balanced between the groups, except for thicker @entity1 and larger @entity4 in the bevacizumab group, potentially to the disadvantage of the study group. Nevertheless, bevacizumab prophylaxis significantly reduced the rate of iris rubeosis from 36% to 4% (log-rank test P = .02) and tended to shorten the time to retinal reapplication until laser photocoagulation of the nonperfusion areas could be performed. CONCLUSIONS: Prophylactic intravitreal bevacizumab in @entity0 treated with proton therapy for @entity5 with @entity4 prevented @entity3 , until laser photocoagulation to the reapplied retina could be performed.

title: Prophylactic use of bevacizumab to avoid XXXX following proton therapy for @entity5 .

answer: @entity3


abstract: PURPOSE: To investigate whether the prophylactic use of bevacizumab reduces the rate of rubeosis after proton therapy for @entity5 and improves the possibility to treat @entity2 , reapplicated retina with laser photocoagulation. DESIGN: Comparative retrospective case series. METHODS: @entity5 @entity0 with @entity4 and treated with proton therapy were included in this institutional study. Twenty-four eyes received prophylactic intravitreal bevacizumab injections and were compared with a control group of 44 eyes without bevacizumab treatment. Bevacizumab injections were performed at the time of @entity7 clip insertion and were repeated every 2 months during 6 months, and every 3 months thereafter. Ultra-widefield angiography allowed determination of the extent of @entity6 , which was treated with laser photocoagulation after retinal reapplication. Main outcome measures were the time to rubeosis, the time to retinal reattachment, and the time to laser photocoagulation of @entity2 retina. RESULTS: Baseline characteristics were balanced between the groups, except for thicker @entity1 and larger @entity4 in the bevacizumab group, potentially to the disadvantage of the study group. Nevertheless, bevacizumab prophylaxis significantly reduced the rate of iris rubeosis from 36% to 4% (log-rank test P = .02) and tended to shorten the time to retinal reapplication until laser photocoagulation of the nonperfusion areas could be performed. CONCLUSIONS: Prophylactic intravitreal bevacizumab in @entity0 treated with proton therapy for @entity5 with @entity4 prevented @entity3 , until laser photocoagulation to the reapplied retina could be performed.

title: Prophylactic use of bevacizumab to avoid @entity3 following proton therapy for XXXX .

answer: @entity5


abstract: Lipid and lipid metabolite profiling are important parameters in understanding the pathogenesis of many diseases. Alkynylated @entity4 are potentially useful probes for tracking the fate of @entity2 metabolites. The nonenzymatic and enzymatic oxidations of   -alkynyl linoleic acid and   -alkynyl arachidonic acid were compared to that of linoleic and @entity3 . There was no detectable difference in the primary products of nonenzymatic oxidation, which comprised cis,trans-hydroxy fatty acids. Similar hydroxy fatty acid products were formed when   -alkynyl linoleic acid and   -alkynyl arachidonic acid were reacted with lipoxygenase enzymes that introduce @entity0 at different positions in the @entity1 chains. The rates of oxidation of   -alkynylated fatty acids were reduced compared to those of the natural @entity5 . @entity6 did not oxidize alkynyl linoleic but efficiently oxidized alkynyl arachidonic acid. The products were identified as alkynyl 11-hydroxy-eicosatetraenoic acid, alkynyl 11-hydroxy-8,9-epoxy-eicosatrienoic acid, and alkynyl prostaglandins. This deviation from the metabolic profile of @entity3 may limit the utility of alkynyl arachidonic acid in the tracking of cyclooxygenase-based lipid oxidation. The formation of alkynyl 11-hydroxy-8,9-epoxy-eicosatrienoic acid compared to alkynyl prostaglandins suggests that the   - @entity7 group causes a conformational change in the @entity2 bound to the enzyme, which reduces the efficiency of cyclization of dioxalanyl intermediates to endoperoxide intermediates. Overall,   -alkynyl linoleic acid and   -alkynyl arachidonic acid appear to be metabolically competent surrogates for tracking the fate of @entity4 when looking at models involving autoxidation and oxidation by lipoxygenases.

title: -Alkynyl lipid surrogates for po XXXX free radical and enzymatic oxidations.

answer: @entity4


abstract: The hypothesis that twinning raises risk for @entity1 in childhood is persistent, yet there is limited and inconsistent empirical evidence. Simple mean comparison without control for confounders provides data on prevalence rates but cannot provide knowledge about risk or etiology. To assess the effect of twin relationship on behavior, comparison of patterns of association with single-born siblings may be informative. Analyses of data from an Australian sample of twins and single-born @entity0 (N = 305, mean age 4 years 9 months, and a follow-up 12 months later) were undertaken. The outcome measure was the Strengths and Difficulties Questionnaire. Predictor and control measures were obtained from parent report on the sibling/co-twin relationship behavior, family demographics, and obstetric history. We assessed difference between twins and single-born @entity0 in two respects: (a) mean @entity1 , and (b) patterns of association between sibling relationship and @entity1 , controlling for confounders. Results showed no differences in mean levels of @entity1 between twins and single-born siblings identifying the importance of statistical control for family and obstetric adversity. Differences in patterns of association were found; for twin @entity0 , conflict in their co-twin relationship predicted externalizing behaviors, while for single-born @entity0 conflict predicted internalizing behaviors. The findings of mean differences between twin and single-born @entity0 in social background, but not in @entity1 , underscore the necessity of statistical control to identify risk associated with twinning compared with risk associated with family and obstetric background factors.

title: Do twins differ from single-born XXXX on rates of behavioral difficulty in early childhood? A study of sibling relationship risk factors.

answer: @entity0


abstract: PURPOSE: Assess the relationship between @entity4 ( @entity4 ) measured on bedside portable computed tomography (CT) scans and simultaneously measured @entity2 ( @entity2 ) in @entity0 with severe @entity1 . METHODS: Retrospective cohort study of 57 @entity0 admitted between 2009 and 2013. Linear and logistic regression were used to model the correlation and discrimination between @entity4 and @entity2 or @entity2 , respectively. RESULTS: The cohort had a mean age of 40 years (SD 16) and a median admission Glasgow @entity3 score of 7 (IQR 4-10). The between-rater agreement by intraclass coefficient was 0.89 (95 % CI 0.83-0.93, P < 0.001). The mean @entity4 was 6.7 mm (SD 0.75) and the mean @entity2 during CT was 21.3 mmHg (SD 8.4). Using linear regression, there was a strong correlation between @entity2 and @entity4 (r = 0.74, P < 0.001). @entity4 had an area under the curve to discriminate @entity2 (>= 20 mmHg vs. <20 mmHg) of 0.83 (95 % CI 0.73-0.94). Using a cutoff of 6.0 mm, @entity4 had a sensitivity of 97 %, specificity of 42 %, positive predictive value of 67 %, and a negative predictive value of 92 %. Comparing linear regression models, @entity4 was a much stronger predictor of @entity2 (R(2) of 0.56) compared to other CT features (R(2) of 0.21). CONCLUSIONS: Simultaneous measurement of @entity4 on CT and @entity2 were strongly correlated and @entity4 was discriminative for @entity2 . @entity4 was much more predictive of @entity2 than other CT features. There was excellent agreement between raters in measuring @entity4 .

title: Optic nerve sheath diameter on computed tomography is correlated with simultaneously measured @entity2 in @entity0 with severe XXXX .

answer: @entity1


abstract: PURPOSE: Assess the relationship between @entity4 ( @entity4 ) measured on bedside portable computed tomography (CT) scans and simultaneously measured @entity2 ( @entity2 ) in @entity0 with severe @entity1 . METHODS: Retrospective cohort study of 57 @entity0 admitted between 2009 and 2013. Linear and logistic regression were used to model the correlation and discrimination between @entity4 and @entity2 or @entity2 , respectively. RESULTS: The cohort had a mean age of 40 years (SD 16) and a median admission Glasgow @entity3 score of 7 (IQR 4-10). The between-rater agreement by intraclass coefficient was 0.89 (95 % CI 0.83-0.93, P < 0.001). The mean @entity4 was 6.7 mm (SD 0.75) and the mean @entity2 during CT was 21.3 mmHg (SD 8.4). Using linear regression, there was a strong correlation between @entity2 and @entity4 (r = 0.74, P < 0.001). @entity4 had an area under the curve to discriminate @entity2 (>= 20 mmHg vs. <20 mmHg) of 0.83 (95 % CI 0.73-0.94). Using a cutoff of 6.0 mm, @entity4 had a sensitivity of 97 %, specificity of 42 %, positive predictive value of 67 %, and a negative predictive value of 92 %. Comparing linear regression models, @entity4 was a much stronger predictor of @entity2 (R(2) of 0.56) compared to other CT features (R(2) of 0.21). CONCLUSIONS: Simultaneous measurement of @entity4 on CT and @entity2 were strongly correlated and @entity4 was discriminative for @entity2 . @entity4 was much more predictive of @entity2 than other CT features. There was excellent agreement between raters in measuring @entity4 .

title: Optic nerve sheath diameter on computed tomography is correlated with simultaneously measured XXXX in @entity0 with severe @entity1 .

answer: @entity2


abstract: PURPOSE: Assess the relationship between @entity4 ( @entity4 ) measured on bedside portable computed tomography (CT) scans and simultaneously measured @entity2 ( @entity2 ) in @entity0 with severe @entity1 . METHODS: Retrospective cohort study of 57 @entity0 admitted between 2009 and 2013. Linear and logistic regression were used to model the correlation and discrimination between @entity4 and @entity2 or @entity2 , respectively. RESULTS: The cohort had a mean age of 40 years (SD 16) and a median admission Glasgow @entity3 score of 7 (IQR 4-10). The between-rater agreement by intraclass coefficient was 0.89 (95 % CI 0.83-0.93, P < 0.001). The mean @entity4 was 6.7 mm (SD 0.75) and the mean @entity2 during CT was 21.3 mmHg (SD 8.4). Using linear regression, there was a strong correlation between @entity2 and @entity4 (r = 0.74, P < 0.001). @entity4 had an area under the curve to discriminate @entity2 (>= 20 mmHg vs. <20 mmHg) of 0.83 (95 % CI 0.73-0.94). Using a cutoff of 6.0 mm, @entity4 had a sensitivity of 97 %, specificity of 42 %, positive predictive value of 67 %, and a negative predictive value of 92 %. Comparing linear regression models, @entity4 was a much stronger predictor of @entity2 (R(2) of 0.56) compared to other CT features (R(2) of 0.21). CONCLUSIONS: Simultaneous measurement of @entity4 on CT and @entity2 were strongly correlated and @entity4 was discriminative for @entity2 . @entity4 was much more predictive of @entity2 than other CT features. There was excellent agreement between raters in measuring @entity4 .

title: Optic nerve sheath diameter on computed tomography is correlated with simultaneously measured @entity2 in XXXX with severe @entity1 .

answer: @entity0


abstract: INTRODUCTION AND OBJECTIVES: @entity0 - and procedure-related factors are known to be associated with @entity1 after transcatheter aortic valve implantation. Nevertheless, this entity may also be caused by a specific device-host interaction due to the biomechanical properties of the valves, independently of clinical factors. We sought to elucidate the role of frame geometry in the occurrence of @entity1 after Medtronic CoreValve(  ) and Edwards SAPIEN(  ) valve implantation. METHODS: We conducted an observational study encompassing 134 @entity0 undergoing transcatheter aortic valve implantation with the Medtronic CoreValve(  ) and Edwards SAPIEN(  ) valve. Frame analysis was performed at 3 predefined levels of both valves by rotational angiography using dedicated motion compensation software. A distinction was made between @entity0 with no-to-mild and moderate-to-severe @entity1 by echocardiography. RESULTS: Baseline characteristics were similar between the 2 valves. Despite greater use of predilation in the CoreValve(  ) (95.2% vs 82.0%; P=.012), more oversizing (perimeter, 114  7% vs 103  7%; P<.001), and the same depth of implantation (noncoronary sinus, 7  4 vs 8  2mm; left coronary sinus, 8  4 vs 8  2mm), it was less expanded and more eccentric than the Edwards SAPIEN(  ) (83  7% vs 92  4%; P<.001 and 82  8% vs 95  3%; P<.001, respectively) and when eccentricity was adjusted for the @entity0 's annulus eccentricity (4  13% vs 21  11%; P<.001). Eccentricity and adjusted eccentricity were associated with moderate-to-severe @entity1 . CONCLUSIONS: Independently of @entity0 - and procedure-related factors, there is a device-specific device-host interaction that explains @entity1 after transcatheter aortic valve implantation.

title: Differences in Frame Geometry Between Balloon-expandable and Self-expanding Transcatheter Heart Valves and Association With XXXX .

answer: @entity1


abstract: AIMS: To establish if the microbiology and the TEXAS, PEDIS and Wagner wound classifications of the @entity1 ( @entity1 ) predict amputation. METHODS: Prospective cohort study of 250 @entity0 with @entity1 from 2009 to 2013. Tissue samples for culture were obtained and wound classification scores were recorded at admission. RESULTS: Infection was monomicrobial in 131 @entity0 (52%). @entity3 was the most frequent pathogen (76 @entity0 , 30%); being @entity6 -resistant @entity3 in 26% (20/76) @entity2 and Enterobacter faecalis were 2nd and 3rd most frequent pathogens. Two hundred nine @entity0 (85%) needed amputation being major in 25 @entity0 (10%). The three wound scales associated minor amputation but did not predict this outcome. Predictors of minor amputation in the multivariate analysis were the presence of @entity8 , the location of the wound in the forefoot and of major amputation elevated @entity4 ( @entity4 ) levels. A low ankle-brachial index (ABI) predicted major amputation in the follow-up. Overall, 74% of gram-positives were sensitive to @entity9 and 98% to @entity5 and 90% of gram-negatives to @entity7 and 95% to carbapenems. CONCLUSIONS: The presence of @entity8 and the location of the wound in the forefoot predict minor amputation and elevated @entity4 levels predict major amputation. In the follow-up a low ABI predicts major amputation.

title: Influence of wound scores and microbiology on the outcome of the XXXX .

answer: @entity1


abstract: OBJECTIVE: Although statin therapy has been linked to fewer short-term complications after infrainguinal bypass, its effect on long-term survival remains unclear. We therefore examined associations between statin use and long-term mortality, graft occlusion, and amputation after infrainguinal bypass. METHODS: We used the Vascular Study Group of New England registry to study 2067 @entity0 (71% male; mean age, 67     11  years; 67% with @entity2 [ @entity2 ]) who underwent infrainguinal bypass from 2003 to 2011. Of these, 1537 (74%) were on statins perioperatively and at 1-year follow-up, and 530 received no statin. We examined crude, adjusted, and propensity-matched rates of 5-year surviva1, 1-year amputation, graft occlusion, and perioperative @entity5 . RESULTS: @entity0 taking statins at the time of surgery and at the 1-year follow-up were more likely to have @entity4 (38% vs 22%; P  < .001), @entity1 (51% vs 36%; P  < .001), @entity3 (89% vs 77%; P  < .001), and prior revascularization procedures (50% vs 38%; P  < .001). Despite higher comorbidity burdens, long-term survival was better for @entity0 taking statins in crude (risk ratio [RR], 0.7; P  < .001), adjusted (hazard ratio, 0.7; P  = .001), and propensity-matched analyses (hazard ratio, 0.7; P  = .03). In subgroup analysis, a survival advantage was evident in @entity0 on statins with @entity2 (5-year survival rate, 63% vs 54%; log-rank, P  = .01) but not claudication (5-year survival rate, 84% vs 80%; log-rank, P  = .59). Statin therapy was not associated with 1-year rates of major amputation (12% vs 11%; P  = .84) or graft occlusion (20% vs 18%; P  = .58) in @entity2 @entity0 . Perioperative @entity5 occurred more frequently in @entity0 on a statin in crude analysis (RR, 2.2; P  = .01) but not in the matched cohort (RR, 1.9; P  = .17). CONCLUSIONS: Statin therapy is associated with a 5-year survival benefit after infrainguinal bypass in @entity0 with @entity2 . However, 1-year limb-related outcomes were not influenced by statin use in our large observational cohort of @entity0 undergoing revascularization in New England.

title: Statin therapy after infrainguinal bypass surgery for XXXX is associated with improved 5-year survival.

answer: @entity2


abstract: BACKGROUND: Endoscopic submucosal dissection (ESD) has recently provided a new treatment strategy for large @entity3 , as an alternative to laparoscopy-assisted colectomy (LAC). Prospective comparative data on the perioperative course of ESD vis-  -vis LAC are scarce. METHODS: We prospectively evaluated the perioperative course of colorectal ESD in 300 @entity0 . We evaluated en bloc and curative resection, procedure duration, postoperative parameters [white blood cell count (WBC), @entity9 ( @entity9 ), and hemoglobin], @entity5 , recovery duration (time to achieve full mobilization, normal diet, and length of hospitalization), and complications. We also prospectively evaluated 190 @entity0 undergoing LAC as a control group. RESULTS: The median size of the lesions was 30  mm for ESDs (LACs: 20  mm). The median procedure time was 90  min for ESDs (LACs: 185  min). @entity4 was reported in 4  % of ESDs (LACs: 54  %). Only 4  % of ESDs required analgesia (LACs: 61  %). Between the preoperative period and postoperative day 1, the mean difference in WBC and @entity9 was +1,300/ l for ESDs (LACs: +3,100/ l), and +0.91  mg/dl for ESDs (LACs: +3.96  mg/dl), respectively. A >= 2  g/dl decrease in hemoglobin was observed in 5  % of ESDs (LACs: 30.0  %). Complications were seen in 7  % of ESDs (LACs: 15  %). The rate of delayed @entity7 and perforation was 5 and 1.7  % of ESDs, respectively. Although only one of them required laparotomy for @entity6 caused by delayed perforation, others could be managed endoscopically. Additional LAC was required in 16 ESDs due to redefined risk for lymph node @entity1 . The median hospital stay was 5  days for ESDs (LACs: 10  days). These were consecutive @entity0 with prospective data collection. CONCLUSIONS: Colorectal ESD is effective, minimally invasive and safe in terms of periperative clinical course. Colorectal ESD provides advantages for treatment of large @entity8 and @entity2 with no risk of lymph node @entity1 .

title: Potential perioperative advantage of XXXX versus laparoscopy-assisted colectomy.

answer: @entity3


abstract: UNASSIGNED: OBJECT The objective of this study was to compare the incidence of degeneration and need for subsequent fusion surgery between @entity0 who were treated nonsurgically and @entity0 treated with fusion after a diagnosis of thoracic-or lumbar-level @entity1 without @entity2 . METHODS The authors performed a retrospective study of Orthopedic United Healthcare @entity0 diagnosed with @entity1 . @entity0 were filtered into thoracic and @entity1 groups using diagnostic codes and then assigned to one of 2 treatment subgroups (fusion surgery or no surgery) on the basis of procedural codes. @entity3 and follow-up surgery were recorded. Chi-square statistical analysis was used. RESULTS Of 3699 @entity0 diagnosed with a thoracic @entity1 , 117 (3.2%) underwent thoracic fusion and 3215 (86.9%) were treated nonsurgically. Within 3 years, 147 (4.6%) @entity0 from the nonsurgical subgroup and fewer than 11 (0.9%-8.5%) from the fusion subgroup were diagnosed with @entity3 . From the nonsurgical subgroup, 11 (0.3%) @entity0 underwent a thoracic surgery related to @entity3 compared with zero from the fusion group (p > 0.05). Of 5016 @entity0 diagnosed with @entity1 , 150 (3.0%) underwent fusion and 4371 (87.1%) had no surgery. Within 3 years, 503 @entity0 (11.5%) from the nonsurgical subgroup and 35 (23.3%) from the fusion subgroup were diagnosed with @entity3 (p < 0.05). From the nonsurgical subgroup, 42 (1.0%) went on to have surgery related to @entity3 , compared with fewer than 11 (0.7%-6.7%) from the fusion subgroup (values not precise due to privacy limitations). CONCLUSIONS Fusion surgery for thoracic @entity1 does not appear to increase the likelihood of undergoing future surgery. In the lumbar region, initial fusion surgery appears to increase the incidence of @entity3 and could potentially necessitate future surgeries.

title: Effects of fusion and conservative treatment on @entity3 and rates of subsequent surgery after thoracolumbar XXXX .

answer: @entity1


abstract: UNASSIGNED: OBJECT The objective of this study was to compare the incidence of degeneration and need for subsequent fusion surgery between @entity0 who were treated nonsurgically and @entity0 treated with fusion after a diagnosis of thoracic-or lumbar-level @entity1 without @entity2 . METHODS The authors performed a retrospective study of Orthopedic United Healthcare @entity0 diagnosed with @entity1 . @entity0 were filtered into thoracic and @entity1 groups using diagnostic codes and then assigned to one of 2 treatment subgroups (fusion surgery or no surgery) on the basis of procedural codes. @entity3 and follow-up surgery were recorded. Chi-square statistical analysis was used. RESULTS Of 3699 @entity0 diagnosed with a thoracic @entity1 , 117 (3.2%) underwent thoracic fusion and 3215 (86.9%) were treated nonsurgically. Within 3 years, 147 (4.6%) @entity0 from the nonsurgical subgroup and fewer than 11 (0.9%-8.5%) from the fusion subgroup were diagnosed with @entity3 . From the nonsurgical subgroup, 11 (0.3%) @entity0 underwent a thoracic surgery related to @entity3 compared with zero from the fusion group (p > 0.05). Of 5016 @entity0 diagnosed with @entity1 , 150 (3.0%) underwent fusion and 4371 (87.1%) had no surgery. Within 3 years, 503 @entity0 (11.5%) from the nonsurgical subgroup and 35 (23.3%) from the fusion subgroup were diagnosed with @entity3 (p < 0.05). From the nonsurgical subgroup, 42 (1.0%) went on to have surgery related to @entity3 , compared with fewer than 11 (0.7%-6.7%) from the fusion subgroup (values not precise due to privacy limitations). CONCLUSIONS Fusion surgery for thoracic @entity1 does not appear to increase the likelihood of undergoing future surgery. In the lumbar region, initial fusion surgery appears to increase the incidence of @entity3 and could potentially necessitate future surgeries.

title: Effects of fusion and conservative treatment on XXXX and rates of subsequent surgery after thoracolumbar @entity1 .

answer: @entity3


abstract: BACKGROUND: In the Netherlands, prenatal screening follows an opting in system and comprises two non-invasive tests: the combined test to screen for trisomy 21 at 12 weeks of gestation and the @entity2 scan to detect structural anomalies at 20 weeks. Midwives counsel about prenatal screening tests for @entity1 and they are increasingly having to counsel @entity0 from religious backgrounds beyond their experience. This study assessed midwives' perceptions and practices regarding taking client's religious backgrounds into account during counseling. As Islam is the commonest non-western religion, we were particularly interested in midwives' knowledge of whether pregnancy termination is allowed in Islam. METHODS: This exploratory study is part of the DELIVER study, which evaluated primary care midwifery in The Netherlands between September 2009 and January 2011. A questionnaire was sent to all 108 midwives of the twenty practices participating in the study. RESULTS: Of 98 respondents (response rate 92%), 68 (69%) said they took account of the client's religion. The two main reasons for not doing so were that religion was considered irrelevant in the decision-making process and that it should be up to clients to initiate such discussions. Midwives' own religious backgrounds were independent of whether they paid attention to the clients' religious backgrounds. Eighty midwives (82%) said they did not counsel Muslim @entity0 differently from other @entity0 . Although midwives with relatively many Muslim clients had more knowledge of Islamic attitudes to terminating pregnancy in general than midwives with relatively fewer Muslim clients, the specific knowledge of termination regarding trisomy 21 and other @entity1 was limited in both groups. CONCLUSION: While many midwives took client's religion into account, few knew much about Islamic beliefs on prenatal screening for @entity1 . Midwives identified a need for additional education. To meet the needs of the changing client population, counselors need more knowledge of religious opinions about the termination of pregnancy and the skills to approach religious issues with clients.

title: Prenatal screening for XXXX : exploring midwives' perceptions of counseling clients with religious backgrounds.

answer: @entity1


abstract: Because of the complex anatomy of the foot, rarity of @entity2 of the foot, and subtle radiographic cues, foot injuries are commonly overlooked and mis/undiagnosed. This study seeks to investigate a @entity0 population whose @entity1 , including @entity2 and @entity5 , were missed on initial examination, in order to analyze factors of known, missed injuries and provide insight into methods for reducing the incidence of missed diagnoses. Surgical cases between January 1999 and May 2011 were queried and retrospectively reviewed to identify missed @entity1 . Of 1682 surgical cases reviewed, 27 @entity0 with @entity1 (ies), which were subsequently confirmed by imaging studies, were identified. Using the Orthopaedic @entity1 Association classification, @entity2 and dislocation subtypes were classified. A medical record review was performed to assess demographic and surgical data elements. In this study population, 7 types of @entity1 (talus, calcaneal, navicular, and @entity2 as well as subtalar, calcaneocuboid, and @entity4 ) were diagnosed in 27 @entity0 . All @entity0 required surgical intervention. @entity2 were the most commonly missed injury. In @entity0 with @entity3 , there was a strong correlation between talus and navicular @entity2 (r = -0.60; P < .01) as well as a moderate correlation between talus @entity2 and @entity5 (r = -0.46; P = .02). The presence of a calcaneal @entity2 significantly decreased the time to definitive diagnosis (P = .01). Male @entity0 ' diagnoses were delayed an average of 324 days and females 105 days (P = .04). A moderate correlation was found between @entity0 age at injury and time to diagnosis (r = -0.47; P = .04), with a decreased time to diagnosis as @entity0 age increased. Significant factors were identified in this @entity0 population, including @entity0 sex and age, which may contribute to missed or delayed diagnosis in the clinical setting. Prompt and accurate diagnosis of @entity1 may improve long-term outcomes. LEVELS OF EVIDENCE: Care Management, Level V.

title: XXXX : an analysis of factors in cases of known delayed diagnosis and methods for improving identification.

answer: @entity1


abstract: OBJECTIVE: Individuals frequently involved in jumping, pivoting or cutting are at increased risk of @entity1 , including anterior cruciate ligament (ACL) tears. We sought to use meta-analytic techniques to establish whether neuromuscular and proprioceptive training is efficacious in preventing knee and @entity0 and to identify factors related to greater efficacy of such programs. METHODS: We performed a systematic literature search of studies published in English between 1996 and 2014. Intervention efficacy was ascertained from incidence rate ratios (IRRs) weighted by their precision (1/variance) using a random effects model. Separate analyses were performed for knee and @entity0 . We examined whether year of publication, study quality, or specific components of the intervention were associated with efficacy of the intervention in a meta-regression analysis. RESULTS: Twenty-four studies met the inclusion criteria and were used in the meta-analysis. The mean study sample was 1,093 subjects. Twenty studies reported data on knee @entity0 and 16 on @entity0 . Maximum Jadad score was 3 (on a 0-5 scale). The summary incidence rate ratio was estimated at 0.731 (95% CI: 0.614, 0.871) for @entity1 and 0.493 (95% CI: 0.285, 0.854) for @entity0 , indicating a protective effect of intervention. Meta-regression analysis did not identify specific intervention components associated with greater efficacy but established that later year of publication was associated with more conservative estimates of intervention efficacy. CONCLUSION: The current meta-analysis provides evidence that neuromuscular and proprioceptive training reduces knee @entity0 in particular. Later publication date was associated with higher quality studies and more conservative efficacy estimates. As study quality was generally low, these data suggest that higher quality studies should be implemented to confirm the preventive efficacy of such programs.

title: Effectiveness of XXXX and Anterior Cruciate Ligament Tear Prevention Programs: A Meta-Analysis.

answer: @entity1


abstract: BACKGROUND: In @entity1 ( @entity1 ), it is well known that postoperative @entity2 reduces right ventricular function during long-term follow-up. Complete repair without a transannular patch should help avoid @entity2 . Recently, primary complete repair has been preferred to the staged repair with use of a Blalock-Taussig shunt (BTS) even in neonates or small @entity0 ; however, little has been reported about the influence of a BTS on pulmonary annular growth. METHODS: We examined 40 @entity0 with @entity1 or double-outlet right ventricle with @entity3 . Twenty-one @entity0 received a BTS before complete repair, whereas 19 @entity0 underwent primary complete repair. Pulmonary annular size was measured by echocardiography before BTS, complete repair, or both, and ventricular volume was measured by cardiac catheterization. RESULTS: There were no significant differences in complete repair age or body size between the groups. Pulmonary annulus sizes in the BTS group were smaller than those in the primary repair group (Z score, -5.1    2.5 vs -3.7    1.8). After the BTS, significant annular growth (Z score, -2.8    2.1) was observed (p = 0.0028), with a significant increase in left ventricular end-diastolic volume (p = 0.015). When @entity0 with severe @entity3 (Z score > -7.0) were excluded, pulmonary annular preservation at complete repair was achieved in 64.7% (11/17) of the BTS group and 36.8% (7/19) of the primary repair group (p = 0.088). CONCLUSIONS: The @entity4 increased the pulmonary annular size and the left ventricular volume during the 6 months before complete repair, resulting in preservation of the @entity2 .

title: Pulmonary annulus growth after the modified Blalock-Taussig shunt in XXXX .

answer: @entity1


abstract: BACKGROUND: Objective of the study was to evaluate the diagnostic value of novel ultrasonographic modalities in comparison with simultaneously performed liver biopsy. METHODS: The results of simultaneously performed examinations using Acoustic Structure Quantification (ASQ), Virtual Touch Imaging and Quantification (VTIQ) and Virtual Touch Tissue Quantification (VTTQ) were compared with the findings of liver biopsy in @entity0 with a wide variety of diffuse hepatopathies (n = 51). The histologically determined @entity1 stage according to Desmet and Scheuer was compared with quantitative measurements returned by the ultrasonographic imaging modalities. RESULTS: No statistically significant correlation with histologically determined @entity1 stage could be identified for any measurements returned using ASQ. Increasing severity of @entity4 , however, was associated with a reduction in the @entity2 ( @entity2 ) ratio (r =   -0.55; p < 0.0001). The shearwave velocities measured using VTTQ satisfyingly correlated with @entity1 stage (r = 0.56; p > 0.0001). @entity1 stages > F2 were associated with an area under the curve (AUC) of 0.94 (95%-CI:0.84-0.99). A cut-off value for shearwave velocity of 1.66 m/s was determined with a sensitivity of 100% and a specificity of 84 %. VTIQ showed a less pronounced but acceptable correlation with @entity1 stage (r = 0.35; p = 0.0154). For @entity1 stages > F2 analysis showed an AUC of 0.84 (95%-CI:0.70-0.93). The cut-off value was 1.82 m/s with a sensitivity of 100% and a specificity of 58 %. CONCLUSION: While ASQ showed no diagnostic advantage in our @entity0 collective, VTTQ showed high reliability for determining severe liver @entity1 in a group of @entity0 with diffuse @entity3 of different etiology.

title: Comparison of Acoustic Structure Quantification (ASQ), shearwave elastography and histology in XXXX with diffuse hepatopathies.

answer: @entity0


abstract: PURPOSE: To review outcomes of continuous motor/somatosensory-evoked potential (MEP/SSEP) monitoring, cerebrospinal fluid drainage, and selective use of iliofemoral conduits in @entity0 undergoing endovascular repair of descending thoracic @entity3 (DTA) and @entity5 ( @entity5 ). METHODS: The clinical data of 49 @entity0 (mean age 75  8 years; 38 @entity0 ) who underwent endovascular repair of DTA and @entity5 (2011-2014) were reviewed. All @entity0 had cerebrospinal fluid drainage, permissive @entity2 (mean arterial pressure >= 80 mm Hg), and MEP/SSEP monitoring. There were 44 (90%) @entity0 with @entity5 and 5 (10%) with DTA. Types I and II @entity5 were repaired in staged procedures. Iliofemoral conduits were used for small iliac arteries and to minimize time of lower extremity @entity1 in @entity0 with difficult anatomy. In @entity0 with changes in MEP/SSEPs, a standardized protocol was employed to optimize spinal cord perfusion and restore lower extremity blood flow. Endpoints were mortality, @entity4 ( @entity4 ), and lower extremity @entity1 complications. RESULTS: Sixteen (33%) @entity0 had staged TAAA repair. A total of 163 visceral arteries were targeted by fenestrations and branches (mean 3.7  1.0 vessels/ @entity0 ). Temporary iliofemoral conduits were used in 16 limbs/14 @entity0 . A stable MEP/SSEP was achieved in all @entity0 . Thirty-one (63%) @entity0 had a >= 75% decrease in MEP/SSEP amplitude in 50 limbs starting on average 75  28 minutes after obtaining vascular access. MEP/SSEP amplitude improved with maneuvers in 12 (39%) @entity0 and returned to baseline with restoration of lower extremity flow in all except 1 @entity0 who developed immediate @entity4 . Thirty-day mortality was 4%. Three (6%) @entity0 had @entity4 , 2 permanent and 1 temporary at 14 days. There were no lower extremity @entity1 complications. CONCLUSION: Neuromonitoring predicted immediate @entity4 and allowed use of a protocol to optimize spinal cord and lower extremity perfusion during complex endovascular aortic repair. Larger clinical experience is needed to evaluate the efficacy of neuromonitoring to prevent @entity4 .

title: Neuromonitoring, Cerebrospinal Fluid Drainage, and Selective Use of Iliofemoral Conduits to Minimize Risk of XXXX During Complex Endovascular Aortic Repair.

answer: @entity4


abstract: BACKGROUND/AIM: @entity1 is a common @entity0 worldwide. Chromatin remodeling complexes have emerged as @entity0 suppressors and include @entity3 ( @entity3 ) 1A, 1B, and 2. We examined their expression and clarified their roles in @entity1 . MATERIALS AND METHODS: The expression of @entity3 was studied by immunohistochemistry in 469 @entity1 and 47 @entity2 samples and was analyzed according to clinicopathological factors. RESULTS: Low expression rates of @entity7 , and 2 in @entity1 were 20%, 10%, and 15% respectively. @entity3 are correlated to each other. Low expression of @entity4 was related to advanced @entity0 and vessel infiltration. Loss of @entity6 and @entity5 was also related to @entity0 progression, but their relationship was weaker than that of @entity4 . CONCLUSION: @entity4 is the strongest @entity0 suppressor in @entity1 among @entity3 . Their aberration might be caused by shared mechanisms such as mutation and methylation.

title: Loss of @entity4 , XXXX , and @entity5 Expression During Progression of @entity1 .

answer: @entity6


abstract: BACKGROUND/AIM: @entity1 is a common @entity0 worldwide. Chromatin remodeling complexes have emerged as @entity0 suppressors and include @entity3 ( @entity3 ) 1A, 1B, and 2. We examined their expression and clarified their roles in @entity1 . MATERIALS AND METHODS: The expression of @entity3 was studied by immunohistochemistry in 469 @entity1 and 47 @entity2 samples and was analyzed according to clinicopathological factors. RESULTS: Low expression rates of @entity7 , and 2 in @entity1 were 20%, 10%, and 15% respectively. @entity3 are correlated to each other. Low expression of @entity4 was related to advanced @entity0 and vessel infiltration. Loss of @entity6 and @entity5 was also related to @entity0 progression, but their relationship was weaker than that of @entity4 . CONCLUSION: @entity4 is the strongest @entity0 suppressor in @entity1 among @entity3 . Their aberration might be caused by shared mechanisms such as mutation and methylation.

title: Loss of XXXX , @entity6 , and @entity5 Expression During Progression of @entity1 .

answer: @entity4


abstract: BACKGROUND/AIM: @entity1 is a common @entity0 worldwide. Chromatin remodeling complexes have emerged as @entity0 suppressors and include @entity3 ( @entity3 ) 1A, 1B, and 2. We examined their expression and clarified their roles in @entity1 . MATERIALS AND METHODS: The expression of @entity3 was studied by immunohistochemistry in 469 @entity1 and 47 @entity2 samples and was analyzed according to clinicopathological factors. RESULTS: Low expression rates of @entity7 , and 2 in @entity1 were 20%, 10%, and 15% respectively. @entity3 are correlated to each other. Low expression of @entity4 was related to advanced @entity0 and vessel infiltration. Loss of @entity6 and @entity5 was also related to @entity0 progression, but their relationship was weaker than that of @entity4 . CONCLUSION: @entity4 is the strongest @entity0 suppressor in @entity1 among @entity3 . Their aberration might be caused by shared mechanisms such as mutation and methylation.

title: Loss of @entity4 , @entity6 , and XXXX Expression During Progression of @entity1 .

answer: @entity5


abstract: BACKGROUND/AIM: @entity1 is a common @entity0 worldwide. Chromatin remodeling complexes have emerged as @entity0 suppressors and include @entity3 ( @entity3 ) 1A, 1B, and 2. We examined their expression and clarified their roles in @entity1 . MATERIALS AND METHODS: The expression of @entity3 was studied by immunohistochemistry in 469 @entity1 and 47 @entity2 samples and was analyzed according to clinicopathological factors. RESULTS: Low expression rates of @entity7 , and 2 in @entity1 were 20%, 10%, and 15% respectively. @entity3 are correlated to each other. Low expression of @entity4 was related to advanced @entity0 and vessel infiltration. Loss of @entity6 and @entity5 was also related to @entity0 progression, but their relationship was weaker than that of @entity4 . CONCLUSION: @entity4 is the strongest @entity0 suppressor in @entity1 among @entity3 . Their aberration might be caused by shared mechanisms such as mutation and methylation.

title: Loss of @entity4 , @entity6 , and @entity5 Expression During Progression of XXXX .

answer: @entity1


abstract: BACKGROUND: Actinic @entity5 (AP) is a type of photodermatosis, the pathophysiology of which has not been determined. AP has been suggested to be a @entity1 reaction to the presence of eosinophils and the local production of IgE. MATERIAL AND METHODS: Descriptive study, using @entity2 blocks of tissue that have been diagnosed with AP from the Dermopathology department, Hospital General Dr. Manuel Gea Gonz  lez. In 66 blocks from 63 @entity0 , eosinophils were identified by @entity3 and @entity4 staining, and mastocytes were labeled by immunohistochemistry. Three random microphotographs (40x) were used, and cell counts were calculated as the mean count in the 3 microphotographs. RESULTS: Forty cases (63.5%) were female, and 23 (36.5%) were male. The mean age was 26.49   14.09 years; regarding the evolution time of the disease, the average was 11.93 years   11.39. In 38 of 63 cases (60%), the lip, skin, and conjunctiva were affected clinically. In 22 of 63 cases (34%), AP @entity6 was the sole manifestation, and in 4 of 63 cases (6%), there were lesions in the skin and conjunctiva. The mean eosinophil count was 9 per case, the average number of mastocytes/field was 28.48 (range 0 to 66) Kruskal-Wallis p=0.001. CONCLUSIONS: There are elements in AP that mediate the reaction of @entity1 type IV b, necessitating the identification of triggering factors. Key words:Actinic @entity5 , eosinophil, @entity1 IV b, IgE, mastocytes.

title: Inmunohistochemical detection of mastocytes in tissue from @entity0 with actinic XXXX .

answer: @entity5


abstract: BACKGROUND: Actinic @entity5 (AP) is a type of photodermatosis, the pathophysiology of which has not been determined. AP has been suggested to be a @entity1 reaction to the presence of eosinophils and the local production of IgE. MATERIAL AND METHODS: Descriptive study, using @entity2 blocks of tissue that have been diagnosed with AP from the Dermopathology department, Hospital General Dr. Manuel Gea Gonz  lez. In 66 blocks from 63 @entity0 , eosinophils were identified by @entity3 and @entity4 staining, and mastocytes were labeled by immunohistochemistry. Three random microphotographs (40x) were used, and cell counts were calculated as the mean count in the 3 microphotographs. RESULTS: Forty cases (63.5%) were female, and 23 (36.5%) were male. The mean age was 26.49   14.09 years; regarding the evolution time of the disease, the average was 11.93 years   11.39. In 38 of 63 cases (60%), the lip, skin, and conjunctiva were affected clinically. In 22 of 63 cases (34%), AP @entity6 was the sole manifestation, and in 4 of 63 cases (6%), there were lesions in the skin and conjunctiva. The mean eosinophil count was 9 per case, the average number of mastocytes/field was 28.48 (range 0 to 66) Kruskal-Wallis p=0.001. CONCLUSIONS: There are elements in AP that mediate the reaction of @entity1 type IV b, necessitating the identification of triggering factors. Key words:Actinic @entity5 , eosinophil, @entity1 IV b, IgE, mastocytes.

title: Inmunohistochemical detection of mastocytes in tissue from XXXX with actinic @entity5 .

answer: @entity0


abstract: OBJECTIVES: To overcome the drawbacks of the Rastelli operation, the modified Lecompte procedure creates a connection from the left ventricle to the aorta with greater freedom from residual obstruction due to the resection of the outlet septum and avoids the implantation of an extracardiac valved conduit. We evaluated the effectiveness of this technique with analysis of our 25-year long-term results. METHODS: We reviewed the records of 50 @entity0 who underwent the modified Lecompte procedure during the past 25 years. The median age at operation was 1.95 years (range, 0.30-12.48 years). The diagnoses involved anomalies of the ventriculoarterial connection with @entity2 and @entity4 , such as @entity5 , double outlet right ventricle, and double outlet left ventricle. RESULTS: There were 2 early deaths (4.0%). During a mean follow-up of 14.2    7.9 years (range, 0.2-25 years), there were 4 late deaths. Actuarial survival was 87.3%    4.9% at 25 years. The freedom from @entity1 and reoperation at 25 years was 87.7%    6.2% and 25.2%    9.4%, respectively. The freedom from reoperation for @entity3 and right @entity3 at 25 years was 88.5%    5.4% and 49.6%    9.0%, respectively. At last follow-up, 43 survivors (97.7%) are in New York Heart Association class I. CONCLUSIONS: The modified Lecompte procedure has excellent long-term results for treating anomalies of ventriculoarterial connection with @entity2 and @entity4 . Early repair is possible with low mortality and morbidity in terms of @entity1 , reoperation for right or @entity3 , and functional class.

title: Twenty-five years' experience of modified Lecompte procedure for the anomalies of ventriculoarterial connection with XXXX and pulmonary stenosis.

answer: @entity2


abstract: AIMS/HYPOTHESIS: Urinary albumin excretion is a strong predictor of @entity1 . It is uncertain whether improvement from microalbuminuria or deterioration from normoalbuminuria over time in @entity0 with differing changes in @entity2 and BP change their cardiovascular risk. METHODS: Data on mortality, cardiovascular and renal outcomes were analysed in 22,984 @entity0 from two large parallel randomised clinical trials followed for 56 months. A central laboratory analysed first morning spot urine samples at baseline and after 24 months, and events were recorded over the subsequent 32 months. @entity0 were stratified by changes in @entity3 , @entity2 status and mean systolic BP over 2 years. RESULTS: There was a strong association between @entity3 status and all-cause and cardiovascular mortality and combined cardiovascular and renal endpoints (all p < 0.0001). Changes in systolic BP control had no effect on mortality, whereas @entity2 status was significantly associated with all outcomes. Irrespective of BP control or @entity2 status, @entity0 showing an improvement from microalbuminuria to normoalbuminuria after 2 years were at a lower risk of all outcome measures than @entity0 showing deterioration from normoalbuminuria to microalbuminuria (HR for all-cause mortality 0.65 [0.52-0.83], p = 0.0004). CONCLUSIONS/INTERPRETATION: @entity0 who showed improvement to normoalbuminuria over 2 years were at lower risk of all-cause and cardiovascular mortality and of cardiovascular and renal events than those who deteriorated to microalbuminuria over time. @entity3 over time was significantly better than @entity2 status and BP control in predicting mortality and both cardiovascular and renal outcomes in @entity0 at a high cardiovascular risk.

title: Mortality and morbidity in relation to changes in @entity3 , XXXX status and systolic blood pressure: an analysis of the ONTARGET and TRANSCEND studies.

answer: @entity2


abstract: AIMS/HYPOTHESIS: Urinary albumin excretion is a strong predictor of @entity1 . It is uncertain whether improvement from microalbuminuria or deterioration from normoalbuminuria over time in @entity0 with differing changes in @entity2 and BP change their cardiovascular risk. METHODS: Data on mortality, cardiovascular and renal outcomes were analysed in 22,984 @entity0 from two large parallel randomised clinical trials followed for 56 months. A central laboratory analysed first morning spot urine samples at baseline and after 24 months, and events were recorded over the subsequent 32 months. @entity0 were stratified by changes in @entity3 , @entity2 status and mean systolic BP over 2 years. RESULTS: There was a strong association between @entity3 status and all-cause and cardiovascular mortality and combined cardiovascular and renal endpoints (all p < 0.0001). Changes in systolic BP control had no effect on mortality, whereas @entity2 status was significantly associated with all outcomes. Irrespective of BP control or @entity2 status, @entity0 showing an improvement from microalbuminuria to normoalbuminuria after 2 years were at a lower risk of all outcome measures than @entity0 showing deterioration from normoalbuminuria to microalbuminuria (HR for all-cause mortality 0.65 [0.52-0.83], p = 0.0004). CONCLUSIONS/INTERPRETATION: @entity0 who showed improvement to normoalbuminuria over 2 years were at lower risk of all-cause and cardiovascular mortality and of cardiovascular and renal events than those who deteriorated to microalbuminuria over time. @entity3 over time was significantly better than @entity2 status and BP control in predicting mortality and both cardiovascular and renal outcomes in @entity0 at a high cardiovascular risk.

title: Mortality and morbidity in relation to changes in XXXX , @entity2 status and systolic blood pressure: an analysis of the ONTARGET and TRANSCEND studies.

answer: @entity3


abstract: @entity0 undergoing hematopoietic stem cell transplantation (HSCT) are submitted to a conditioning regimen of high-dose chemotherapy, with or without radiation therapy, which usually results in oral ulcerations and mucosal barrier breakdown. @entity9 ( @entity9 ) is a common and debilitating @entity1 side effect of autologous and allogeneic HSCT. The aim of this study was to evaluate the effect of low-level laser therapy (LLLT) on the severity of @entity9 and inflammatory mediator ( @entity3 , @entity4 , @entity6 , @entity5 , @entity8 , metalloproteinases, and growth factors) levels in saliva and blood of HSCT @entity0 . Thirty @entity0 were randomly assigned to two groups: control (n   =   15) and laser (n   =   15). LLLT was applied from the first day of the conditioning regimen until day 7 post-HSCT (D   +   7). Saliva and blood were collected from @entity0 on admission (AD), @entity10 , D   +   7, and on @entity2 ( @entity2 ). Clinical results showed less severe @entity9 in the laser group (p   <   0.05). The LLLT group showed increased @entity7 ( @entity7 ) levels in saliva on D   +   7 (p   =   0.04). Significant differences were also observed for @entity5 on D   +   7 and on @entity2 in blood plasma, when compared to the control group (p   <   0.05). No significant differences were seen in saliva or blood for the other inflammatory mediators investigated. LLLT was clinically effective in reducing the severity of chemotherapy-induced @entity9 in HSCT @entity0 , and its mechanism of action does not seem to be completely linked to the modulation of pro- or anti-inflammatory cytokines, growth factors or matrix metalloproteinases.

title: Effect of low-level laser therapy on inflammatory mediator release during chemotherapy-induced XXXX : a randomized preliminary study.

answer: @entity9


abstract: OBJECTIVES: In cases of cardiac surgery via a minimally invasive right minithoracotomy approach, cardiopulmonary bypass is established with peripheral arterial cannulation, frequently with a single femoral artery. Occasionally, alternative perfusion access is required to prevent perfusion site-related complications. In this study, the feasibility of alternative perfusion strategies was verified by comparing the postoperative outcomes and complications. METHODS: The records of 91 consecutive @entity0 (68 @entity0 , 23 @entity0 ; mean age 40.7      16.5  years) who underwent @entity2 ( @entity2 ) closure via a right minithoracotomy approach between January 2009 and September 2014 were reviewed. @entity0 were divided into two groups: those with single femoral arterial access (SF group, n  =  84), and those with alternative perfusion access (ALT group, n  =  7, bilateral femoral arterial cannulation in 6, side-arm graft anastomosed to the femoral artery in 1). RESULTS: Femoral artery diameter was smaller in the ALT group than in the SF group (6.5      0.5 vs. 7.3      1.0  mm, P  =  0.013). Operating time was longer in the ALT group than in the SF group (259.2      54.0 vs. 208.3      54.9  min, P  =  0.031). One @entity0 was converted to ascending aortic cannulation owing to high perfusion pressure. Postoperative major cardiac or cerebrovascular events, such as @entity3 , @entity1 , or @entity4 , did not occur in either group. CONCLUSIONS: Alternative perfusion access was safe in @entity2 closure via a right minithoracotomy approach. Precise preoperative evaluation of the iliofemoral artery is important for choosing the appropriate perfusion strategy.

title: Alternative peripheral perfusion strategies for safe cardiopulmonary bypass in XXXX closure via a right minithoracotomy approach.

answer: @entity2


abstract: BACKGROUND: The use of an autologous pulmonary vein (PV) conduit for reconstruction of the pulmonary artery (PA) in lung-sparing resections was first described in 2009, but to date only two case reports appeared and no medium-term and long-term results have been reported, to our knowledge. We present the first case series with medium-term follow-up. METHODS: Between December 2009 and December 2012, 9 @entity0 undergoing PA sleeve resection for centrally located @entity1 received reconstruction by this technique. Three of these @entity0 underwent induction chemotherapy. The venous graft was obtained from the proximal extraparenchymal portion of the superior PV and was sutured to the proximal and distal PA stumps with the standard anastomotic technique. RESULTS: All 9 @entity0 underwent left upper lobectomy with sleeve resection of the PA without associated bronchoplasty. The postoperative morbidity rate was 33% (1 chylothorax, 1 @entity3 , and 1 parenchymal atelectasis). No adverse events related to the reconstructive procedure occurred. There was no postoperative mortality. Complete patency of the reconstructed PA was shown in all @entity0 by postoperative contrast computed tomography every 6 months. All @entity0 are alive at a mean follow-up time of 32    12.4 months (range, 6 to 42 months). @entity2 recurrence has been observed in 2 @entity0 (1 local, 1 systemic). The median survival time is 38 months. The median disease-free survival time @entity4 months. CONCLUSIONS: Reconstruction of the PA by a PV graft is a feasible and effective option for parenchymal-sparing resections. The PV conduit shows tissue characteristics similar to those of the arterial wall. This technique is safe and is supported by good medium-term results.

title: Pulmonary artery reconstruction with pulmonary vein conduit for XXXX : medium-term results.

answer: @entity1


abstract: @entity1 is the most common @entity3 diagnosed worldwide. Metastatic presentation of the disease is frequent. Apart from the usual sites of @entity2 (bone, adrenals, liver, brain), a particular site for @entity2 is represented by skin. The case we report is about a 66 year-old @entity0 with cutaneous @entity2 from @entity1 . A 66 year-old @entity0 , with a previous history of abdominal aortic aneurism, @entity10 , @entity12 , @entity4 , was admitted to our institution for @entity1 . After accurate preoperative @entity3 , @entity0 underwent a thoracotomic left lower lobectomy. Histological examination revealed a @entity7 : G2-3, pT2bN0. @entity0 underwent oncological evaluation for the scheduled follow up. After 6 months @entity0 went back to our observation for the appearance of a skin nodule, firm, dischromic, @entity6 and ulcerated, localized in right iliac fossa. Biopsies demonstrated the nodule to be @entity7 . @entity0 underwent a CT scan of the abdomen and thorax, which revealed the absence of @entity11 by the @entity3 . @entity0 underwent surgical @entity5 . Final histological examination confirmed the lesion to be @entity2 of squamocellular @entity1 . @entity2 from @entity1 occur in about 2,5-7,5% of cases. Median survival for these @entity0 is 2,9 months. The most common type of @entity3 , according to Japanese Authors, is @entity9 followed by @entity7 . Some studies demonstrated the adequacy of surgery followed by chemotherapy, in case of single lesion. In case of multiple cutaneous @entity2 , many Authors suggest only chemotherapy, although the ideal scheme hasn't been discovered yet. Cutaneous @entity2 from @entity1 are rare; however the appearance of @entity8 , in @entity0 with a positive oncological history, requires much attention. Accurate evaluation of the @entity0 is paramount in choosing the adequate therapeutic algorithm. KEY WORDS: Chemotherapy, @entity1 , Skin @entity2 .

title: XXXX . Case report.

answer: @entity1


abstract: BACKGROUND: Heavy tea consumption is suggested to be unsuitable for @entity2 @entity0 . However, the bioactive substances in different varieties of tea leaves are very different. This study compares the effects of three Chinese teas  -  @entity5 , C. ptilophylla and C. assamica var. kucha  -  on blood pressure (BP) and heart rate in spontaneously @entity2 @entity1 (SHRs). RESULTS: Intragastric administration of @entity5 extract led to an acute @entity2 (SBP), diastolic blood pressure (DBP) and heart rate in SHRs. However, C. ptilophylla and C. assamica var. kucha exerted no obvious influences on SBP, @entity7 or heart rate. Similar to the extract of @entity5 , intragastric administration of @entity6 also led to an acute increase in BP and heart rate in SHRs. In contrast, @entity8 and @entity10  -  @entity9 predominantly contained in C. ptilophylla and C. assamica var. kucha, respectively  -  had no pressor effects. The effect of @entity6 on BP was related to the regulation of plasma @entity4 and @entity3 levels in SHRs. CONCLUSION: The different effects of @entity5 , C. ptilophylla and C. assamica var. kucha on BP might be explained, at least partially, by the differences in the varieties and contents of @entity9 .    2014 Society of Chemical Industry.

title: Differing chemical compositions of three teas may explain their different effects on acute blood pressure in spontaneously XXXX @entity1 .

answer: @entity2


abstract: BACKGROUND: Heavy tea consumption is suggested to be unsuitable for @entity2 @entity0 . However, the bioactive substances in different varieties of tea leaves are very different. This study compares the effects of three Chinese teas  -  @entity5 , C. ptilophylla and C. assamica var. kucha  -  on blood pressure (BP) and heart rate in spontaneously @entity2 @entity1 (SHRs). RESULTS: Intragastric administration of @entity5 extract led to an acute @entity2 (SBP), diastolic blood pressure (DBP) and heart rate in SHRs. However, C. ptilophylla and C. assamica var. kucha exerted no obvious influences on SBP, @entity7 or heart rate. Similar to the extract of @entity5 , intragastric administration of @entity6 also led to an acute increase in BP and heart rate in SHRs. In contrast, @entity8 and @entity10  -  @entity9 predominantly contained in C. ptilophylla and C. assamica var. kucha, respectively  -  had no pressor effects. The effect of @entity6 on BP was related to the regulation of plasma @entity4 and @entity3 levels in SHRs. CONCLUSION: The different effects of @entity5 , C. ptilophylla and C. assamica var. kucha on BP might be explained, at least partially, by the differences in the varieties and contents of @entity9 .    2014 Society of Chemical Industry.

title: Differing chemical compositions of three teas may explain their different effects on acute blood pressure in spontaneously @entity2 XXXX .

answer: @entity1


abstract: Variation in nasal floor topography has generated both neontological and paleontological interest. Three categories of nasal floor shape (Franciscus: J Hum Evol 44 (2003) 699-727) have been used when analyzing this trait in extant @entity0 and fossil Homo: flat, sloped, and @entity1 (or "bi-level"). Variation in the frequency of these configurations within and among extant and fossil @entity0 has been well-documented (Franciscus: J Hum Evol 44 (2003) 699-727; Wu et al.: Anthropol Sci 120 (2012) 217-226). However, variation in this trait in Homo has been observed primarily in adults, with comparatively small subadult sample sizes and/or large age gradients that may not sufficiently track key ontogenetic changes. In this study, we investigate the ontogeny of nasal floor shape in a relatively large cross-sectional age sample of extant @entity0 (n = 382) ranging from 4.0 months fetal to 21 years post-natal. Results indicate that no fetal or young @entity0 individuals possess a @entity1 nasal floor, and that a @entity1 nasal floor, when present (ca. 21% of the sample), does not occur until 3.0 years postnatal. A canonical variates analysis of maxillary shape revealed that individuals with @entity1 nasal floors were also characterized by relatively taller anterior alveolar regions. This suggests that palate remodeling at about 3.0-3.5 years after birth, under the influence of tooth development, strongly influences nasal floor variation, and that various aspects of dental development, including larger crown/root size, may contribute to the development of a @entity1 nasal floor. These results in extant @entity0 may help explain the high frequency of this trait found in @entity2 and other archaic Homo maxillae. Am J Phys Anthropol 155:369-378, 2014.    2014 Wiley Periodicals, Inc.

title: The ontogeny of nasal floor shape variation in extant XXXX .

answer: @entity0


abstract: OBJECTIVE: To determine the effect of @entity2 in @entity0 with secondary @entity3 . DESIGN: Phase II clinical trial. SETTING: Community dwelling @entity0 making visits to physician offices. @entity0 (S): @entity0 with secondary @entity3 . INTERVENTION(S): Oral administration of @entity2 or 1% topical T gel. MAIN OUTCOME MEASURE(S): Luteinizing hormone, FSH, T, and semen analysis. RESULT(S): Treatment with @entity2 resulted in increased morning serum T, E2, and LH levels similar to those obtained with a topical T gel in @entity0 with secondary @entity3 . Follicle-stimulating hormone and LH were increased with @entity2 , and sperm counts were conserved. CONCLUSION(S): @entity2 reverses the two hallmarks of secondary @entity3 , namely, @entity1 and low or inappropriately normal LH while preserving sperm production. CLINICAL TRIAL REGISTRATION NUMBER: NCT01270841 (ClinicalTrials.gov Identifier NCT01270841).

title: XXXX stimulates testosterone production while preventing oligospermia: a  randomized phase II clinical trial comparing topical testosterone.

answer: @entity2


abstract: @entity1 is the leading cause of @entity3 during the first four decades of life in the developed countries. Its haemodynamic response underpins the @entity0 's initial ability to survive, and the response to treatment and subsequent morbidity and resolution. @entity1 causes a number of insults including @entity4 , tissue injury (nociception) and, predominantly, in military casualties, blast from explosions. This article discusses aspects of the haemodynamic responses to these insults and subsequent treatment. 'Simple' @entity4 ( @entity2 without significant volume of tissue damage) causes a biphasic response: mean arterial blood pressure (MBP) is initially maintained by the baroreflex ( @entity6 and increased vascular resistance, Phase 1), followed by a sudden decrease in MAP initiated by a second reflex (decrease in vascular resistance and @entity8 , Phase 2). Phase 2 may be protective. The response to tissue injury attenuates Phase 2 and may cause a deleterious haemodynamic redistribution that compromises blood flow to some vital organs. In contrast, thoracic blast exposure augments Phase 2 of the response to @entity4 . However, hypoxaemia from @entity7 limits the effectiveness of @entity5 resuscitation by augmenting the @entity10 state. An alternative strategy ('hybrid resuscitation') whereby tissue perfusion is increased after the first hour of @entity5 resuscitation by adopting a revised normotensive target may ameliorate these problems. Finally, @entity9 also attenuates Phase 2 of the response to @entity4 in some, but not all, species and this is associated with poor outcome. The impact on @entity0 @entity0 is currently unknown and is the subject of a current physiological investigation.

title: Haemodynamic changes in XXXX .

answer: @entity1


abstract: BACKGROUND: According to the Response Assessment in Neuro-Oncology criteria, new enhancement within the radiation field on contrast enhanced T1-weighted images within 12 weeks after completion of radiotherapy should not qualify for progressive disease, since up to 50% of these cases may be pseudoprogression ( @entity3 ). To validate this concept, we assessed incidence and @entity2 ( @entity2 ) of @entity0 with suspected and confirmed @entity3 dependent on different time intervals and definitions of @entity3 . METHODS: @entity0 with newly diagnosed @entity1 and an enhancement increase of at least 25% after completion of standard radiochemotherapy at month 1, 4, 7, or 10 were eligible. Based on the development of the enhancement in follow-up examinations, @entity0 were categorized as either @entity3 (subgrouped as complete resolution/decrease >50% and decrease <50%/stable) or true progression. RESULTS: Out of 548 @entity0 , 79 fulfilled the inclusion criteria. Of these 79 @entity0 , 9 (11.4%) showed @entity3 (6/45 @entity0 at 1 month, 2/17 at 4 months, 1/9 at 7 months, and 0/8 at 10 months). Complete resolution of the enhancement was found in 1, decrease >50% in 3, decrease <50% in 2, and stable enhancement in 3 @entity0 with @entity3 . @entity0 with @entity3 showed a significantly longer @entity2 (P < .012). No difference in @entity2 was found among @entity3 subgroups. CONCLUSIONS: This series challenges the current concept of @entity3 . Even though we could confirm a prolonged @entity2 of @entity0 with @entity3 , the incidence of @entity3 was lower than reported previously and extended beyond 12 weeks.

title: Pseudoprogression in @entity0 with XXXX : clinical relevance despite low incidence.

answer: @entity1


abstract: BACKGROUND: According to the Response Assessment in Neuro-Oncology criteria, new enhancement within the radiation field on contrast enhanced T1-weighted images within 12 weeks after completion of radiotherapy should not qualify for progressive disease, since up to 50% of these cases may be pseudoprogression ( @entity3 ). To validate this concept, we assessed incidence and @entity2 ( @entity2 ) of @entity0 with suspected and confirmed @entity3 dependent on different time intervals and definitions of @entity3 . METHODS: @entity0 with newly diagnosed @entity1 and an enhancement increase of at least 25% after completion of standard radiochemotherapy at month 1, 4, 7, or 10 were eligible. Based on the development of the enhancement in follow-up examinations, @entity0 were categorized as either @entity3 (subgrouped as complete resolution/decrease >50% and decrease <50%/stable) or true progression. RESULTS: Out of 548 @entity0 , 79 fulfilled the inclusion criteria. Of these 79 @entity0 , 9 (11.4%) showed @entity3 (6/45 @entity0 at 1 month, 2/17 at 4 months, 1/9 at 7 months, and 0/8 at 10 months). Complete resolution of the enhancement was found in 1, decrease >50% in 3, decrease <50% in 2, and stable enhancement in 3 @entity0 with @entity3 . @entity0 with @entity3 showed a significantly longer @entity2 (P < .012). No difference in @entity2 was found among @entity3 subgroups. CONCLUSIONS: This series challenges the current concept of @entity3 . Even though we could confirm a prolonged @entity2 of @entity0 with @entity3 , the incidence of @entity3 was lower than reported previously and extended beyond 12 weeks.

title: Pseudoprogression in XXXX with @entity1 : clinical relevance despite low incidence.

answer: @entity0


abstract: Ageing is associated with an overall decline in the functional capacity of tissues and stem cells, including haematopoietic stem and progenitor cells (HSPCs), as well as @entity1 . Dietary restriction (DR) is a recognised anti-ageing intervention that extends lifespan and improves health in several organisms. To investigate the role of @entity2 and telomerase in haematopoietic ageing, we compared the HSPC profile and clonogenic capacity of bone marrow cells from wild type with telomerase-deficient @entity0 and the effect of DR on these parameters. Compared with young @entity0 , aged wild type @entity0 demonstrated a significant accumulation of HSPCs (1.3% vs 0.2%, P=0.002) and elevated numbers of granulocyte/macrophage colony forming units (CFU-GM, 26.4 vs 17.3, P=0.0037) consistent with myeloid "skewing" of haematopoiesis. DR was able to restrict the increase in HSPC number as well as the myeloid "skewing" in aged wild type @entity0 . In order to analyse the influence of short @entity2 on the ageing phenotype we examined @entity0 lacking the RNA template for telomerase, @entity4 (-/-). Telomere shortening resulted in a similar bone marrow phenotype to that seen in aged @entity0 , with significantly increased HSPC numbers and an increased formation of all myeloid colony types but at a younger age than wild type @entity0 . However, an additional increase in erythroid colonies (BFU-E) was also evident. @entity0 lacking telomerase reverse transcriptase without shortened @entity2 , @entity3 (-/-), also presented with augmented haematopoietic ageing which was ameliorated by DR, demonstrating that the effect of DR was not dependent on the presence of telomerase in HSPCs. We conclude that whilst shortened @entity2 mimic some aspects of haematopoietic ageing, both shortened @entity2 and the lack of telomerase produce specific phenotypes, some of which can be prevented by dietary restriction.

title: Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short XXXX exacerbates the ageing phenotype.

answer: @entity2


abstract: BACKGROUND: @entity1 ( @entity1 ) includes different @entity1 patterns with varied degrees of articular @entity2 and displacement. Many kinds of fixators, including newly designed plate with locking screws, were applied to treat these complicated fractures. We intended to follow up the surgical outcomes of (1) unilateral locking plate, (2) classic dual plates, or (3) hybrid dual plates for @entity1 . MATERIALS AND METHODS: We retrospectively reviewed 76 @entity0 with @entity1 , Schatzker types V and VI, who we operated from June 2006 to May 2009 in our institute. Excluding @entity0 who expired due to other medical conditions and without complete follow-up, 45 @entity0 were sorted out in this series. The scheme of surgical intervention was designed by visiting staff, and 15 @entity0 , as group I, were treated with unilateral locking plate. The other 19 @entity0 , as group II, were treated with classic dual plates. The residual 11 @entity0 , as group III, were treated with hybrid dual plates (one lateral approach @entity4 ( @entity4 )   +   medial anti-gliding plate). All @entity0 were under periodic F/U at about 6  weeks interval for at least 18  months postoperatively. RESULTS: In group I, 13 cases achieved solid bony union without obvious traumatic OA change, limitation of ROM, or @entity3 . In groups II and III, 15 and 10 @entity0 reached the same goal, respectively. By analysis of the recorded parameters with statistical software (SPSS 12.0), there were five parameters with significant difference, including Schatzker classification, operation time, staged treatment or not, hospitalization period, and hardware impingement. CONCLUSIONS: There was no significant statistical difference of union rate between these three groups in our series. Based on our clinical follow-up, several key points were emphasized: (1) Soft tissue problems should be kept in mind, and usage of locking plate can reduce the discomfort of hardware impingement effectively. (2) The single lateral approach technique for @entity1 with locking plate results in less operation time and shorter hospitalization period. (3) If the medial buttress cannot be established by reduction of the lateral @entity1 , then open reduction of the medial side is necessary and buttresses the medial fragment by dual plates.

title: Comparison of outcome of unilateral locking plate and dual plating in the treatment of bicondylar XXXX .

answer: @entity1


abstract: @entity5 is a @entity6 characterized by plasma cell clonal expansion as well as end-organ damage due to increased levels of monoclonal proteins in both the plasma and urine. The clinical syndrome is characterized by @entity8 , @entity2 , @entity4 , and bone involvement that leads to pathologic @entity1 . This progressive disease can result in significant @entity0 morbidity and mortality. Despite advances with treatment options and autologous stem cell transplantation, @entity5 remains incurable. Current front-line therapies include proteasome inhibitors, immunomodulators, @entity11 , and @entity3 . Due to the advent of the immunomodulatory agents @entity9 and @entity10 , as well as the proteasome inhibitor @entity7 , overall survival in @entity0 with @entity5 has improved greatly. However, once @entity0 progress through front-line therapy and have relapsed or refractory disease, treatment options have historically been very limited. @entity13 , a second-generation proteasome inhibitor, has shown impressive response rates as a single agent in the relapsed and refractory @entity0 setting; this includes @entity0 who are refractory to previous @entity7 therapy. In addition, a third-generation immunomodulator, @entity12 , has also shown promising results in a similar @entity0 population, including those @entity0 who have been shown to be refractory to @entity10 and @entity7 . Adverse effects of both of these medications have been considered tolerable in the relapsed or refractory population, especially considering the benefits that have been shown. Continuing clinical research will reveal the utility of these agents in combination regimens or in a front-line setting for @entity0 with @entity5 .

title: XXXX and @entity12 : recent advances in the treatment of @entity5 .

answer: @entity13


abstract: @entity5 is a @entity6 characterized by plasma cell clonal expansion as well as end-organ damage due to increased levels of monoclonal proteins in both the plasma and urine. The clinical syndrome is characterized by @entity8 , @entity2 , @entity4 , and bone involvement that leads to pathologic @entity1 . This progressive disease can result in significant @entity0 morbidity and mortality. Despite advances with treatment options and autologous stem cell transplantation, @entity5 remains incurable. Current front-line therapies include proteasome inhibitors, immunomodulators, @entity11 , and @entity3 . Due to the advent of the immunomodulatory agents @entity9 and @entity10 , as well as the proteasome inhibitor @entity7 , overall survival in @entity0 with @entity5 has improved greatly. However, once @entity0 progress through front-line therapy and have relapsed or refractory disease, treatment options have historically been very limited. @entity13 , a second-generation proteasome inhibitor, has shown impressive response rates as a single agent in the relapsed and refractory @entity0 setting; this includes @entity0 who are refractory to previous @entity7 therapy. In addition, a third-generation immunomodulator, @entity12 , has also shown promising results in a similar @entity0 population, including those @entity0 who have been shown to be refractory to @entity10 and @entity7 . Adverse effects of both of these medications have been considered tolerable in the relapsed or refractory population, especially considering the benefits that have been shown. Continuing clinical research will reveal the utility of these agents in combination regimens or in a front-line setting for @entity0 with @entity5 .

title: @entity13 and XXXX : recent advances in the treatment of @entity5 .

answer: @entity12


abstract: @entity5 is a @entity6 characterized by plasma cell clonal expansion as well as end-organ damage due to increased levels of monoclonal proteins in both the plasma and urine. The clinical syndrome is characterized by @entity8 , @entity2 , @entity4 , and bone involvement that leads to pathologic @entity1 . This progressive disease can result in significant @entity0 morbidity and mortality. Despite advances with treatment options and autologous stem cell transplantation, @entity5 remains incurable. Current front-line therapies include proteasome inhibitors, immunomodulators, @entity11 , and @entity3 . Due to the advent of the immunomodulatory agents @entity9 and @entity10 , as well as the proteasome inhibitor @entity7 , overall survival in @entity0 with @entity5 has improved greatly. However, once @entity0 progress through front-line therapy and have relapsed or refractory disease, treatment options have historically been very limited. @entity13 , a second-generation proteasome inhibitor, has shown impressive response rates as a single agent in the relapsed and refractory @entity0 setting; this includes @entity0 who are refractory to previous @entity7 therapy. In addition, a third-generation immunomodulator, @entity12 , has also shown promising results in a similar @entity0 population, including those @entity0 who have been shown to be refractory to @entity10 and @entity7 . Adverse effects of both of these medications have been considered tolerable in the relapsed or refractory population, especially considering the benefits that have been shown. Continuing clinical research will reveal the utility of these agents in combination regimens or in a front-line setting for @entity0 with @entity5 .

title: @entity13 and @entity12 : recent advances in the treatment of XXXX .

answer: @entity5


abstract: The influence of intraocular pressure (IOP) on the visual field of @entity2 @entity0 is discussed; the criterion level for postoperative IOP control was set at 20 mmHg. When the IOP exceeded this level for two consecutive months, the IOP control was judged to be a failure, and the surgical results were analysed by a life-table method. Argon laser trabeculoplasty (ALT) with 50 shots over 180 degrees of the angle was used routinely, because of fewer complications than with 360 degrees ALT. A second session sometimes improved the final success rate, which was about 57% in primary @entity3 and 94% in @entity8 after a follow-up period of two years and two months. All @entity0 (120 eyes) required drugs, but their use could be reduced in about 35%. The IOP distribution in successful cases showed a peak at 16 to 17 mmHg, and the IOP was 15 mmHg or less in 21%. In trabeculectomy, pretreatment with topical @entity5 and @entity1 drip infusion was advocated, and concentrated @entity6 was used during surgery. These procedures reduced the incidence of @entity7 and associated @entity4 . The final success rate was about 60% after five years of follow-up. The IOP distribution after more than two years peaked at 13 to 15 mmHg, and the IOP was 15 mmHg or less in 53%.

title: Surgical treatment of XXXX .

answer: @entity3


abstract: A sporadic case of @entity10 of the simple form (Peiffer) was reported. The @entity0 was three-year-old @entity0 who had suffered from progressive @entity3 and @entity1 such as @entity8 , @entity11 and @entity4 of the extremities for eighteen months after she had showed normal development till one and a half years old and died from @entity7 . On admission, computerized tomogram scan demonstrated diffuse low density lesions of the cerebral white matter extending subsequently to the subcortical white matter. Examination of cerebrospinal fluid revealed only slight increase of protein. Lysosomal enzyme activities such as arylsulfatase and @entity5 in the white blood cells were normal except for distinctly low activity of a-mannosidase without any clinical symptoms suggesting @entity12 . @entity6 in blood were normal. The brain weighed 900 gm. On the coronal sections most part of the cerebral white matter was so strongly degenerated and disappeared that the lateral ventricular structure was not discernible. Histologically, a diffuse and symmetrical demylination, loss of axons including U fibers and moderate @entity9 were observed in the residual white matter in the cerebrum and pons. There was no inflammatory cells and metachromatic substances. Large amount of sudanophilic droplets showing polarizing cross and needle like crystals were found in the intra- and/or extracytoplasm of macrophages. @entity2 with little tissue reaction were also found in the cerebellum, medulla oblongata and in pyramidal tracts through midbrain to cervical spinal cord. There were slight loss of neurons and moderate @entity9 in the cerebral cortex and basal ganglia. There were no Rosenthal fibers and no sparing of islets of myelin.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of simple form of XXXX of a @entity0 which showed a marked loss of cerebral white matter and fatty liver].

answer: @entity10


abstract: A sporadic case of @entity10 of the simple form (Peiffer) was reported. The @entity0 was three-year-old @entity0 who had suffered from progressive @entity3 and @entity1 such as @entity8 , @entity11 and @entity4 of the extremities for eighteen months after she had showed normal development till one and a half years old and died from @entity7 . On admission, computerized tomogram scan demonstrated diffuse low density lesions of the cerebral white matter extending subsequently to the subcortical white matter. Examination of cerebrospinal fluid revealed only slight increase of protein. Lysosomal enzyme activities such as arylsulfatase and @entity5 in the white blood cells were normal except for distinctly low activity of a-mannosidase without any clinical symptoms suggesting @entity12 . @entity6 in blood were normal. The brain weighed 900 gm. On the coronal sections most part of the cerebral white matter was so strongly degenerated and disappeared that the lateral ventricular structure was not discernible. Histologically, a diffuse and symmetrical demylination, loss of axons including U fibers and moderate @entity9 were observed in the residual white matter in the cerebrum and pons. There was no inflammatory cells and metachromatic substances. Large amount of sudanophilic droplets showing polarizing cross and needle like crystals were found in the intra- and/or extracytoplasm of macrophages. @entity2 with little tissue reaction were also found in the cerebellum, medulla oblongata and in pyramidal tracts through midbrain to cervical spinal cord. There were slight loss of neurons and moderate @entity9 in the cerebral cortex and basal ganglia. There were no Rosenthal fibers and no sparing of islets of myelin.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of simple form of @entity10 of a XXXX which showed a marked loss of cerebral white matter and fatty liver].

answer: @entity0


abstract: OBJECTIVE: To overcome current limitations of Tissue Engineering (TE) strategies, deeper comprehension on meniscus biology is required. This study aims to combine biomechanical segmental analysis of fresh @entity0 meniscus tissues and its correlation with architectural and cellular characterization. METHOD: Morphologically intact menisci, from 44 live donors were studied after division into three radial segments. Dynamic mechanical analysis (DMA) was performed at physiological-like conditions. Micro-computed tomography (CT) analysis of freeze-dried samples assessed micro-structure. Flow cytometry, histology and histomorphometry were used for cellular study and quantification. RESULTS: Anterior segments present significantly higher damping properties. Mid body fresh medial meniscus presents higher values of E' compared to lateral. Cyclic loads influence the viscoelastic behavior of menisci. By increasing the frequency leads to an increase in stiffness. Conversely, with increasing frequencies, the capacity to dissipate energy and damping properties initially decrease and then rise again. Age and gender directly correlate with higher E' and tan   . Micro-CT analysis revealed that mean porosity was 55.5 (21.2-89.8)% and 64.7 (47.7-81.8)% for freeze-dried lateral and medial meniscus, respectively. Predominant cells are positive for @entity2 , @entity6 , @entity5 and CD105, and lack @entity3 , @entity4 and @entity1 (present in smaller populations). Histomorphometry revealed that cellularity decreases from vascular zone 1 to zone 3. Anterior segments of lateral and medial meniscus have inferior cellularity as compared to mid body and posterior ones. CONCLUSION: Menisci are not uniform structures. Anterior segments have lower cellularity and higher damping. Cyclic loads influence viscoelastic characteristics. Future TE therapies should consider segmental architecture, cellularity and biomechanics of fresh tissue.

title: Biomechanical and cellular segmental characterization of XXXX meniscus: building the basis for Tissue Engineering therapies.

answer: @entity0


abstract: UNASSIGNED: Purpose A preliminary project to correlate MR findings with mapping prostate biopsy to help differentiate malignant transitional zone lesions form @entity3 ( @entity3 ) nodules. Materials and Methods Institutional IRB approved retrospective study with 14 @entity0 suspected of having @entity2 who underwent both prostate 3T MRI using endorectal coil and 3D transperineal mapping prostate biopsy. MR exams were independently reviewed by two abdominal radiologists blinded to pathology with disagreement resolved by consensus. An @entity1 was defined as having hypointense T2 signal subjectively without corresponding T1 high signal intensity and low signal on ADC maps in the central gland. Mapping biopsy consisted of systematic transperineal US guided biopsy with 55-108 cores per @entity0 . Results Twenty-nine lesions were detected on MRI. Of these, 13 correlated with Gleason 6 or higher biopsy samples. 16 were biopsy negative. Among the various MRI characteristics assessed, lack of T2 hypointense rim demonstrated the highest specificity (93%) and positive predictive value (89%). Highest sensitivity (85%) and negative predictive value (78%) were seen with ill-defined nodules. When suspicious MR characteristics were combined, the specificity and @entity4 rose to 100% while sensitivity decreased to 45% and NPV decreased to 73%. Conclusions Preliminary study indicates MR findings which can help differentiate a @entity3 nodule from transitional @entity2 which could help direct biopsy in the large and growing number of @entity0 suspected of having @entity2 . Further work will be needed for validation.

title: Multi-parametric MRI findings of transitional XXXX : correlation with 3-dimensional transperineal mapping biopsy.

answer: @entity2


abstract: The purpose of our study was to analyze the clinical relevance of computerized tomography (CT) in providing the diagnosis of @entity1 ( @entity1 ) in @entity0 with @entity2 . The CT images of 134 @entity0 were reviewed. Two groups of @entity0 were made according to the presence (group 1; n   =   21) or the absence (group 2; n   =   113) of @entity1 . Clinical signs of @entity0 , CT features, complications at surgery, and histological examinations were noted. Inter-observer agreement was assessed by using kappa statistics. Twenty-one @entity0 presenting with CT features of @entity1 were diagnosed. An excellent inter-observer agreement (k   =   0.94) was assessed for the diagnosis of @entity1 . No significant statistical difference in the age distribution was observed between @entity0 with @entity1 (mean age 55) and @entity0 without (mean age 45) (p   =   0.2232). No clinical sign showed a statistically significant association with the presence of @entity1 (p   =   0.707) or with complication encountered at surgery (p   =   0.180). Delay to CT examination was 5.4  days in @entity0 presenting with CT features of @entity1 and of 1.7  days for @entity0 presenting without (p   =   0.0001). Conversely to @entity2 complicated by simple perforation (p   =   0.153) or peri-appendicular abscess (p   =   0.501), @entity2 presenting with @entity1 showed a statistically significant association with complications encountered at surgery (p   =   0.0003) and the need for conversion to open surgery (p   =   0.001). Performing CT in complicated @entity2 provides the diagnosis of @entity1 . Distinction of @entity1 appeared to be of clinical relevance, since immediate surgery in @entity1 was statistically associated with surgical complications and conversion to open surgery in our study.

title: Inflammatory appendix mass in @entity0 with XXXX : CT diagnosis and clinical relevance.

answer: @entity2


abstract: The purpose of our study was to analyze the clinical relevance of computerized tomography (CT) in providing the diagnosis of @entity1 ( @entity1 ) in @entity0 with @entity2 . The CT images of 134 @entity0 were reviewed. Two groups of @entity0 were made according to the presence (group 1; n   =   21) or the absence (group 2; n   =   113) of @entity1 . Clinical signs of @entity0 , CT features, complications at surgery, and histological examinations were noted. Inter-observer agreement was assessed by using kappa statistics. Twenty-one @entity0 presenting with CT features of @entity1 were diagnosed. An excellent inter-observer agreement (k   =   0.94) was assessed for the diagnosis of @entity1 . No significant statistical difference in the age distribution was observed between @entity0 with @entity1 (mean age 55) and @entity0 without (mean age 45) (p   =   0.2232). No clinical sign showed a statistically significant association with the presence of @entity1 (p   =   0.707) or with complication encountered at surgery (p   =   0.180). Delay to CT examination was 5.4  days in @entity0 presenting with CT features of @entity1 and of 1.7  days for @entity0 presenting without (p   =   0.0001). Conversely to @entity2 complicated by simple perforation (p   =   0.153) or peri-appendicular abscess (p   =   0.501), @entity2 presenting with @entity1 showed a statistically significant association with complications encountered at surgery (p   =   0.0003) and the need for conversion to open surgery (p   =   0.001). Performing CT in complicated @entity2 provides the diagnosis of @entity1 . Distinction of @entity1 appeared to be of clinical relevance, since immediate surgery in @entity1 was statistically associated with surgical complications and conversion to open surgery in our study.

title: Inflammatory appendix mass in XXXX with @entity2 : CT diagnosis and clinical relevance.

answer: @entity0