abstract: BACKGROUND: @entity4 may be related to @entity3 in @entity0 with tricuspid aortic valve, while aortic dilatation often is present in @entity0 with @entity6 . We sought to define associations among @entity4 , @entity3 , and @entity5 in @entity0 with tricuspid or @entity6 undergoing surgery for @entity4 in a large referral medical center. METHODS: Two hundred seventy @entity0 with severe @entity4 (tricuspid 175, bicuspid 95) undergoing surgical aortic valve replacement (AVR) were studied. RESULTS: Coronary artery bypass grafting (CABG) surgery plus AVR was required more often in tricuspid compared to @entity6 [62.2% versus 26.3%; p<0.0001; odds ratio 4.5, confidence interval (CI) 2.5-8.3]. The incidence of @entity3 requiring CABG in @entity6 (26.3%) was greater than that expected in the general population for similar age. Thoracic aorta surgery due to @entity2 plus AVR was performed more often in bicuspid compared to tricuspid aortic valve (27.3% versus 3.4%; p<0.0001; odds ratio 7.7, CI 3.0-22.1). The incidence of ascending @entity1 requiring surgery, however, was not more common in tricuspid aortic valve (3.4%) to that expected in the general population for similar age. CONCLUSION: Incidence of @entity3 is high in @entity0 with @entity4 , both in those with tricuspid and @entity6 . Incidence of ascending @entity2 is high in @entity0 with bicuspid, but not those with tricuspid aortic valve. These findings should be taken into consideration in the evaluation and management of @entity0 with the @entity4 complex.

title: The XXXX complex: aortic valve, atherosclerosis, aortopathy.

answer: @entity4


abstract: OBJECTIVES: The aim of this study was to evaluate the pathophysiological features and response to primary percutaneous coronary intervention (PCI) of nonruptured/eroded plaque versus @entity1 as a cause of @entity2 ( @entity2 ). BACKGROUND: Autopsy series identified nonruptured/eroded plaque and @entity1 as the principal pathological substrates underlying @entity5 in @entity2 . The real incidence of different plaque morphologies, associated biological factors, superimposed @entity3 , and their interaction with primary PCI remain largely unknown. METHODS: In a prospective study, 140 @entity0 with @entity2 underwent optical coherence tomography of the @entity6 ( @entity6 ) before PCI, after @entity7 -eluting stent implantation and at 9-month follow-up. Histopathology and immunohistochemistry of @entity3 aspirates and serum biomarkers were assessed at baseline. RESULTS: Culprit plaque morphology was adjudicated in 97 @entity0 : 32 plaques (33.0%) with an intact fibrous cap (IFC), 63 (64.9%) plaques with a ruptured fibrous cap (RFC), and 2 (2.1%) spontaneous dissections. @entity0 with an IFC and RFC had similar clinical characteristics, serum inflammatory, and platelets biomarkers. An IFC presented more frequently with a patent @entity6 (56.2% vs. 34.9%; p  = 0.047), and had fewer lipid areas (lipid-rich areas: 75.0% vs. 100.0%; p  < 0.001) and less residual @entity3 before stenting (white @entity3 : 0.41 mm(3) vs. 1.52 mm(3); p  = 0.001; red  @entity3 : 0 mm(3) vs. 0.29 mm(3); p  = 0.001) with a lower peak of @entity4 kinase-myocardial band (66.6 UI/l vs. 149.8  UI/l; p  = 0.025). At the 9-month optical coherence tomography, IFC and RFC had similar high rates of stent strut  coverage (92.5% vs. 91.2%; p  = 0.15) and similar percentage of @entity8 (12.6 vs. 10.2%; p  = 0.27). No  significant differences in clinical outcomes were observed up to 2 years. CONCLUSIONS: In the present study, an IFC was observed at the culprit lesion site of one-third of STEMIs. IFC, compared with RFC, was associated with higher rates of patent @entity6 at first angiography, fewer lipid areas, and residual endoluminal @entity3 . However, no difference in vascular response to @entity7 -eluting stent was observed. (Optical Coherence Tomography Assessment of Gender Diversity in Primary Angioplasty [OCTAVIA]; NCT01377207).

title: Eroded Versus Ruptured Plaques at the Culprit Site of XXXX : In  Vivo Pathophysiological Features and Response to Primary  PCI.

answer: @entity2


abstract: UNASSIGNED: The present study examined the prognostic ability of our proposed performance status combined Japan Integrated Staging (PS-JIS) system in @entity3 ( @entity3 ) @entity0 with @entity5 ( @entity5 ) comparing with other four prognostic systems including original JIS system, the Barcelona Clinic Liver Cancer classification system, TNM classification system and the @entity2 Italian Program (CLIP) scoring system. A total of 1,170 @entity3 @entity0 complicated with @entity5 were analysed. The disease was staged for all analysed @entity0 by means of the five staging systems. The cumulative @entity4 ( @entity4 ) rate was calculated by Kaplan-Meier method and tested by log-rank test. We also examined prognostic factors associated with @entity4 using univariate and multivariate analyses and compared the prognostic ability in each prognostic system using concordance index (c-index) at 1-, 3- and 5-year time-points. Overall significance in each prognostic system was P<0.001. In the multivariate analyses, @entity1 number, @entity0 -Pugh classification, PS, initial treatment modality and several laboratory parameters were significant independent predictors linked to @entity4 . For all cases, in each time-point, the c-index of PS-JIS system was the highest among five staging systems (0.847, 0.816 and 0.808, respectively), indicating that PS-JIS system has the best predictability among these staging systems. According to subgroup analyses stratified by initial treatment modality, in @entity0 treated with surgical resection (n=205), CLIP scoring system had the highest c-index at every time-point, whereas in @entity0 treated with percutaneous ablative therapies (n=632) at 3- and 5-year time-point and in those with transcatheter arterial therapies (n=281) at every time-point, the c-index of PS-JIS system was the highest. In conclusion, the proposed PS-JIS score can be a useful prognostic system for @entity3 @entity0 complicated with @entity5 .

title: Proposal of the performance status combined Japan Integrated Staging system in XXXX complicated with cirrhosis.

answer: @entity3


abstract: BACKGROUND: @entity6 ( @entity6 ) is an @entity5 @entity2 resin used in, for example, resin systems of pre-impregnated composite materials (prepregs) of the aircraft industry. @entity3 caused by @entity6 in prepregs has been described previously. OBJECTIVES: To report on 9 @entity0 with @entity3 caused by @entity6 in @entity2 glues used in helicopter assembly. METHODS: The @entity0 were examined with patch testing at the Finnish Institute of Occupational Health in 2004-2009. The first @entity0 was diagnosed by testing both components of two @entity2 glues from the workplace, and was also tested with glue ingredients, including @entity6 . The following @entity0 were tested with the glues and @entity6 . The resin parts of the glues were analysed for their @entity2 compounds, including @entity6 . RESULTS: All of the @entity0 had a patch test reaction to one or both of the resin parts of the @entity6 -containing glues. Eight of them had a strong @entity1 to @entity6 , and one had a doubtful reaction to @entity6 . Two of the @entity0 also had an @entity1 to @entity7 ( @entity7 ), another @entity5 @entity2 resin, which was not present in the @entity6 -containing glues. CONCLUSIONS: In aircraft industry workers with suspected @entity4 , @entity5 @entity2 resins should be considered and patch tested as possible contact allergens.

title: Occupational contact dermatitis caused by XXXX @entity2 resins in the aircraft industry.

answer: @entity5


abstract: BACKGROUND: @entity6 ( @entity6 ) is an @entity5 @entity2 resin used in, for example, resin systems of pre-impregnated composite materials (prepregs) of the aircraft industry. @entity3 caused by @entity6 in prepregs has been described previously. OBJECTIVES: To report on 9 @entity0 with @entity3 caused by @entity6 in @entity2 glues used in helicopter assembly. METHODS: The @entity0 were examined with patch testing at the Finnish Institute of Occupational Health in 2004-2009. The first @entity0 was diagnosed by testing both components of two @entity2 glues from the workplace, and was also tested with glue ingredients, including @entity6 . The following @entity0 were tested with the glues and @entity6 . The resin parts of the glues were analysed for their @entity2 compounds, including @entity6 . RESULTS: All of the @entity0 had a patch test reaction to one or both of the resin parts of the @entity6 -containing glues. Eight of them had a strong @entity1 to @entity6 , and one had a doubtful reaction to @entity6 . Two of the @entity0 also had an @entity1 to @entity7 ( @entity7 ), another @entity5 @entity2 resin, which was not present in the @entity6 -containing glues. CONCLUSIONS: In aircraft industry workers with suspected @entity4 , @entity5 @entity2 resins should be considered and patch tested as possible contact allergens.

title: Occupational contact dermatitis caused by @entity5 XXXX resins in the aircraft industry.

answer: @entity2


abstract: PURPOSE: The aim of our study was to investigate the influence of pH and temperature on the stability of @entity2 in analgesic admixtures containing @entity0 and @entity1 . METHODS: All admixtures were combined using a wide range of concentrations, in implantable pumps and syringes, using temperatures from 4  C to 37  C. Quantification was made thanks to a specific chromatographic technique. pH has also been measured throughout the study. RESULTS: Admixtures confirm excellent stability for @entity0 and @entity1 . Concerning @entity2 , an acid hydrolysis has been observed, reducing the time of use of our admixtures in a significant way, but producing non-toxic degradation products. The degradation was linear in all conditions. Inside the implantable pumps at body temperature turned out to be the best conditions for lower protein breakdown. Finally the degradation process showed a high correlation with the pH and the @entity0 concentration with a median loss of concentration delay due to degradation of 3.5 days [3; 5] when pH<4.5 and 13 days [13; 24] when pH>= 4.5. CONCLUSION: Our admixtures showed different stability depending on the drug concentrations, pH and temperature. The great majority of mixtures in real life in our institution have stability highly compatible with our practice and with the delay between two pump refilling.

title: Influence of pH and temperature on XXXX stability in intrathecal analgesic admixtures in implantable pumps and syringes.

answer: @entity2


abstract: BACKGROUND: @entity5 occurs frequently after kidney transplantation and may be reversed when the dosage of the immunosuppressive agents is tapered. However, the effect of transient post-transplantation @entity5 (PTH) on transplantation outcomes is not well described. METHODS: Kidney transplant recipients without @entity1 who underwent kidney transplantation between 2001 and 2012 were enrolled in the study. Transient PTH was defined as recovery from PTH without further antidiabetic therapy and the maintenance of glycated hemoglobin levels  <6.5% at 1 year after transplantation. Persistent PTH until 1 year after transplantation was considered to be new-onset @entity1 after transplantation (NODAT). The factors associated with increased risk of PTH were analyzed. We compared the development of @entity1 , @entity2 , and other transplantation outcomes among @entity0 with no PTH, transient PTH, and NODAT. RESULTS: Among 176 kidney transplant recipients, 106 (60.2%) developed PTH and 58 (54.7%) of 106 @entity0 with PTH had transient PTH. Older age, high body mass index (BMI), and female gender were independent risk factors for transient PTH. The incidence of @entity1 was not significantly different between @entity0 with no PTH and those with transient PTH. The incidence of @entity2 was significantly increased in NODAT group compared with that in no PTH and transient PTH groups. However, the incidences of acute rejection, allograft loss, and @entity0 @entity3 were comparable among the three groups. CONCLUSIONS: Transient @entity5 after kidney transplantation was found to be associated with older age, high body mass index, and female gender. Transient elevation of blood @entity4 level did not affect post-transplantation outcomes, including @entity1 and @entity2 . However, @entity0 with NODAT should be carefully monitored for the occurrence of @entity2 .

title: Effect of Transient Post-transplantation XXXX on the Development of @entity1 and Transplantation Outcomes in Kidney Transplant Recipients.

answer: @entity5


abstract: BACKGROUND: @entity5 occurs frequently after kidney transplantation and may be reversed when the dosage of the immunosuppressive agents is tapered. However, the effect of transient post-transplantation @entity5 (PTH) on transplantation outcomes is not well described. METHODS: Kidney transplant recipients without @entity1 who underwent kidney transplantation between 2001 and 2012 were enrolled in the study. Transient PTH was defined as recovery from PTH without further antidiabetic therapy and the maintenance of glycated hemoglobin levels  <6.5% at 1 year after transplantation. Persistent PTH until 1 year after transplantation was considered to be new-onset @entity1 after transplantation (NODAT). The factors associated with increased risk of PTH were analyzed. We compared the development of @entity1 , @entity2 , and other transplantation outcomes among @entity0 with no PTH, transient PTH, and NODAT. RESULTS: Among 176 kidney transplant recipients, 106 (60.2%) developed PTH and 58 (54.7%) of 106 @entity0 with PTH had transient PTH. Older age, high body mass index (BMI), and female gender were independent risk factors for transient PTH. The incidence of @entity1 was not significantly different between @entity0 with no PTH and those with transient PTH. The incidence of @entity2 was significantly increased in NODAT group compared with that in no PTH and transient PTH groups. However, the incidences of acute rejection, allograft loss, and @entity0 @entity3 were comparable among the three groups. CONCLUSIONS: Transient @entity5 after kidney transplantation was found to be associated with older age, high body mass index, and female gender. Transient elevation of blood @entity4 level did not affect post-transplantation outcomes, including @entity1 and @entity2 . However, @entity0 with NODAT should be carefully monitored for the occurrence of @entity2 .

title: Effect of Transient Post-transplantation @entity5 on the Development of XXXX and Transplantation Outcomes in Kidney Transplant Recipients.

answer: @entity1


abstract: AIM: To evaluate (I) trastuzumab-containing primary systemic therapy (PST) in @entity1 @entity4 ( @entity4 ) overexpressing @entity0 .; (II) compare the @entity1 who achieved and those who did not achieve pathological complete remission (pCR), and (III) analyze the accuracy of different clinical-imaging modalities in @entity2 response monitoring. METHODS: 188 @entity1 who received PST between 2008 and 2014 were reviewed and 43 @entity4 overexpressing @entity0 @entity1 (28 Luminal B/ @entity4 -positive and 15 @entity4 -positive) were enrolled. 26 @entity1 received mostly @entity6 -based PST without trastuzumab (Group 1) and 17 @entity1 received trastuzumab-containing PST (Group 2). We compared the concordance between pCR and complete remission (CR) defined by breast-ultrasound, CR defined by standard @entity3 positron emission tomography and computerized tomography (FDG-PET/CT) criteria (Method 1) and CR defined by a novel, @entity0 specific FDG-PET/CT criteria (Method 2). Sensitivity (sens), specificity (spec), and positive ( @entity5 ) and negative predictive values (NPV) were calculated. RESULTS: Ten @entity1 (38.5%) in Group 1 and eight (47%) in Group 2 achieved pCR. pCR was significantly more frequent in @entity4 -positive than in Luminal B/ @entity4 -positive @entity2 in both Group 1: (P=0.043) and Group 2: (P=0.029). PET/CT evaluated by the @entity0 specific criteria (Method 2) differentiated pCR from non-pCR more accurately in both groups (Group 1: sens=77.8%, spec=%, @entity5 =100%, NPV=71.4%; Group 2: sens=87.5%, spec=62.5%, @entity5 =70%, NPV=83.3%) than standard PET/CT criteria (Method 1) (Group 1: sens=22.2% spec=100% @entity5 =100% NPV=41.7%; in Group 2: sens=37.5%, spec=87.5%, @entity5 =75% NPV=58.3%) or breast ultrasound (Group 1, sens=83.3% spec=25% @entity5 =62.5% NPV=50%; Group 2, sens=100% spec=12.5% @entity5 =41.6% NPV=100%). CONCLUSION: The benefit of targeted treatment with trastuzumab-containing PST in @entity4 overexpressing @entity0 was defined in terms of pCR rate. Luminal B/ @entity4 -positive subtype needs further subdivision to identify @entity1 who would benefit from PST. Combined evaluation of @entity2 response by our novel, @entity0 specific FDG-PET/CT criteria accurately differentiated pCR from non-pCR @entity1 .

title: Response evaluation after primary systemic therapy of XXXX positive @entity0 - an observational cross-sectional study.

answer: @entity4


abstract: AIM: To evaluate (I) trastuzumab-containing primary systemic therapy (PST) in @entity1 @entity4 ( @entity4 ) overexpressing @entity0 .; (II) compare the @entity1 who achieved and those who did not achieve pathological complete remission (pCR), and (III) analyze the accuracy of different clinical-imaging modalities in @entity2 response monitoring. METHODS: 188 @entity1 who received PST between 2008 and 2014 were reviewed and 43 @entity4 overexpressing @entity0 @entity1 (28 Luminal B/ @entity4 -positive and 15 @entity4 -positive) were enrolled. 26 @entity1 received mostly @entity6 -based PST without trastuzumab (Group 1) and 17 @entity1 received trastuzumab-containing PST (Group 2). We compared the concordance between pCR and complete remission (CR) defined by breast-ultrasound, CR defined by standard @entity3 positron emission tomography and computerized tomography (FDG-PET/CT) criteria (Method 1) and CR defined by a novel, @entity0 specific FDG-PET/CT criteria (Method 2). Sensitivity (sens), specificity (spec), and positive ( @entity5 ) and negative predictive values (NPV) were calculated. RESULTS: Ten @entity1 (38.5%) in Group 1 and eight (47%) in Group 2 achieved pCR. pCR was significantly more frequent in @entity4 -positive than in Luminal B/ @entity4 -positive @entity2 in both Group 1: (P=0.043) and Group 2: (P=0.029). PET/CT evaluated by the @entity0 specific criteria (Method 2) differentiated pCR from non-pCR more accurately in both groups (Group 1: sens=77.8%, spec=%, @entity5 =100%, NPV=71.4%; Group 2: sens=87.5%, spec=62.5%, @entity5 =70%, NPV=83.3%) than standard PET/CT criteria (Method 1) (Group 1: sens=22.2% spec=100% @entity5 =100% NPV=41.7%; in Group 2: sens=37.5%, spec=87.5%, @entity5 =75% NPV=58.3%) or breast ultrasound (Group 1, sens=83.3% spec=25% @entity5 =62.5% NPV=50%; Group 2, sens=100% spec=12.5% @entity5 =41.6% NPV=100%). CONCLUSION: The benefit of targeted treatment with trastuzumab-containing PST in @entity4 overexpressing @entity0 was defined in terms of pCR rate. Luminal B/ @entity4 -positive subtype needs further subdivision to identify @entity1 who would benefit from PST. Combined evaluation of @entity2 response by our novel, @entity0 specific FDG-PET/CT criteria accurately differentiated pCR from non-pCR @entity1 .

title: Response evaluation after primary systemic therapy of @entity4 positive XXXX - an observational cross-sectional study.

answer: @entity0


abstract: PURPOSE: To assess the @entity2 in primary @entity4 (PCG) and to identify associated risk factors. METHODS: In this cross-sectional study visual fields of consecutive PCG @entity0 were examined using @entity3 ( @entity3 ) or Goldmann visual field (GVF). All @entity0 had maintained an intraocular pressure (IOP)  <=14 mm Hg on standard care. Mean deviation, pattern standard deviation (PSD), foveal threshold in @entity3 (degrees) in 24 meridians for targets V4e, I4e, I2e in GVF were recorded and evaluated with respect to baseline IOP and age at detection. Statistical analysis was performed by Kruskal Wallis and Mann-Whitney test. Qualitative analysis of GVF and reliable fields in @entity3 was performed. RESULTS: A total of 100 eyes of 77 @entity0 were included: 56 eyes of 47 @entity0 were in the @entity3 group; 44 eyes of 30 @entity0 , in the GVF group. On @entity3 , mean deviation detected at  <=1 month of age was significantly lower than eyes detected after 1 year (P < 0.001). On GVF, the global visual field extent for target I4e and I2e was significantly lower for PCG detected at  <=1 month of age compared to those seen at >1 year (I4e, P < 0.001; I2e, P = 0.005). Mean deviation, PSD, and foveal threshold were significantly lower in PCG with baseline IOP of >30 mm Hg than with IOP of 20-25 mm Hg (mean deviation, P < 0.001; PSD, P = 0.002; foveal threshold, P = 0.002). Extent for targets V4e and I4e on GVF were significantly lower in @entity0 with baseline IOP of >30 mm Hg compared to those with baseline IOP of 20-25 mm Hg (V4e, P = 0.002; I4e, P = 0.003). @entity1 were found in 36 eyes (41%), most ommon being arcuate scotoma (19 eyes [22%]). CONCLUSIONS: PCG detected at age  <=1 month and those having a baseline IOP of >30 mm Hg show greater visual field loss.

title: XXXX in primary @entity4 .

answer: @entity2


abstract: PURPOSE: To assess the @entity2 in primary @entity4 (PCG) and to identify associated risk factors. METHODS: In this cross-sectional study visual fields of consecutive PCG @entity0 were examined using @entity3 ( @entity3 ) or Goldmann visual field (GVF). All @entity0 had maintained an intraocular pressure (IOP)  <=14 mm Hg on standard care. Mean deviation, pattern standard deviation (PSD), foveal threshold in @entity3 (degrees) in 24 meridians for targets V4e, I4e, I2e in GVF were recorded and evaluated with respect to baseline IOP and age at detection. Statistical analysis was performed by Kruskal Wallis and Mann-Whitney test. Qualitative analysis of GVF and reliable fields in @entity3 was performed. RESULTS: A total of 100 eyes of 77 @entity0 were included: 56 eyes of 47 @entity0 were in the @entity3 group; 44 eyes of 30 @entity0 , in the GVF group. On @entity3 , mean deviation detected at  <=1 month of age was significantly lower than eyes detected after 1 year (P < 0.001). On GVF, the global visual field extent for target I4e and I2e was significantly lower for PCG detected at  <=1 month of age compared to those seen at >1 year (I4e, P < 0.001; I2e, P = 0.005). Mean deviation, PSD, and foveal threshold were significantly lower in PCG with baseline IOP of >30 mm Hg than with IOP of 20-25 mm Hg (mean deviation, P < 0.001; PSD, P = 0.002; foveal threshold, P = 0.002). Extent for targets V4e and I4e on GVF were significantly lower in @entity0 with baseline IOP of >30 mm Hg compared to those with baseline IOP of 20-25 mm Hg (V4e, P = 0.002; I4e, P = 0.003). @entity1 were found in 36 eyes (41%), most ommon being arcuate scotoma (19 eyes [22%]). CONCLUSIONS: PCG detected at age  <=1 month and those having a baseline IOP of >30 mm Hg show greater visual field loss.

title: @entity2 in primary XXXX .

answer: @entity4


abstract: BACKGROUND: The fruit of litchi (Litchi chinensis) comprises a white translucent edible aril surrounded by a pericarp. The pericarp of litchi has been the focus of studies associated with fruit size, coloration, cracking and shelf life. However, research at the molecular level has been limited by the lack of genomic and transcriptomic information. In this study, an analysis of the transcriptome of litchi pericarp was performed to obtain information regarding the molecular mechanisms underlying the physiological changes in the pericarp, including those leading to fruit surface coloration. RESULTS: Coincident with the rapid break down of @entity0 , but substantial increase of @entity3 in litchi pericarp as fruit developed, two major physiological changes, degreening and pigmentation were visually apparent. In this study, a cDNA library of litchi pericarp with three different coloration stages was constructed. A total of 4.7 Gb of raw RNA-Seq data was generated and this was then de novo assembled into 51,089 unigenes with a mean length of 737  bp. Approximately 70% of the unigenes (34,705) could be annotated based on public protein databases and, of these, 3,649 genes were significantly differentially expressed between any two coloration stages, while 156 genes were differentially expressed among all three stages. Genes encoding enzymes involved in @entity0 degradation and @entity2 biosynthesis were identified in the transcriptome dataset. The transcript expression patterns of the Stay Green (SGR) protein suggested a key role in @entity0 degradation in the litchi pericarp, and this conclusion was supported by the result of an assay over-expressing LcSGR protein in @entity1 leaves. We also found that the expression levels of most genes especially late @entity3 biosynthesis genes were co-ordinated up-regulated coincident with the accumulation of @entity3 , and that candidate MYB transcription factors that likely regulate @entity2 biosynthesis were identified. CONCLUSIONS: This study provides a large collection of transcripts and expression profiles associated with litchi fruit maturation processes, including coloration. Since most of the unigenes were annotated, they provide a platform for litchi functional genomic research within this species.

title: Transcriptomic analysis of Litchi chinensis pericarp during maturation with a focus on @entity0 degradation and XXXX biosynthesis.

answer: @entity2


abstract: BACKGROUND: The fruit of litchi (Litchi chinensis) comprises a white translucent edible aril surrounded by a pericarp. The pericarp of litchi has been the focus of studies associated with fruit size, coloration, cracking and shelf life. However, research at the molecular level has been limited by the lack of genomic and transcriptomic information. In this study, an analysis of the transcriptome of litchi pericarp was performed to obtain information regarding the molecular mechanisms underlying the physiological changes in the pericarp, including those leading to fruit surface coloration. RESULTS: Coincident with the rapid break down of @entity0 , but substantial increase of @entity3 in litchi pericarp as fruit developed, two major physiological changes, degreening and pigmentation were visually apparent. In this study, a cDNA library of litchi pericarp with three different coloration stages was constructed. A total of 4.7 Gb of raw RNA-Seq data was generated and this was then de novo assembled into 51,089 unigenes with a mean length of 737  bp. Approximately 70% of the unigenes (34,705) could be annotated based on public protein databases and, of these, 3,649 genes were significantly differentially expressed between any two coloration stages, while 156 genes were differentially expressed among all three stages. Genes encoding enzymes involved in @entity0 degradation and @entity2 biosynthesis were identified in the transcriptome dataset. The transcript expression patterns of the Stay Green (SGR) protein suggested a key role in @entity0 degradation in the litchi pericarp, and this conclusion was supported by the result of an assay over-expressing LcSGR protein in @entity1 leaves. We also found that the expression levels of most genes especially late @entity3 biosynthesis genes were co-ordinated up-regulated coincident with the accumulation of @entity3 , and that candidate MYB transcription factors that likely regulate @entity2 biosynthesis were identified. CONCLUSIONS: This study provides a large collection of transcripts and expression profiles associated with litchi fruit maturation processes, including coloration. Since most of the unigenes were annotated, they provide a platform for litchi functional genomic research within this species.

title: Transcriptomic analysis of Litchi chinensis pericarp during maturation with a focus on XXXX degradation and @entity2 biosynthesis.

answer: @entity0


abstract: Multiple studies have addressed @entity4 timing in traumatic @entity5 . However, a precise time for safe and effective chemoprophylaxis is uncertain according to experts. A comprehensive literature review on @entity5 was performed to delineate temporal proportions for 1) spontaneous @entity3 ( @entity3 ) progression, 2) post-chemoprophylaxis @entity3 expansion, and 3) post-chemoprophylaxis @entity4 . Twenty-three publications were found including more than 5,000 @entity0 . Spontaneous @entity3 expansion at 24 hours was 14.8% in 1,437 @entity0 from chemoprophylaxis studies and 29.9% in 1,257 @entity0 not in chemoprophylaxis studies (P   <   0.0001). With low-risk @entity3 (n   =   136), 99% of spontaneous @entity3 expansion occurred within 48 hours. In moderate or high-risk @entity3 (n   =   109), 18% of spontaneous @entity3 expansion occurred after day 3. If @entity0 with pre-chemoprophylaxis @entity3 expansion are included, the post-chemoprophylaxis @entity3 expansion proportion was 5.6% in 1,258 @entity0 with chemoprophylaxis on days 1 to 3 and was 1.5% in 401 with chemoprophylaxis after day 3 (P   =   0.0116). If @entity0 with pre-chemoprophylaxis @entity3 expansion were excluded, the post-chemoprophylaxis @entity3 expansion proportion was 3.1% in 1,570 @entity0 with chemoprophylaxis on days 1 to 3 and was 2.8% in 582 with chemoprophylaxis after day 3 (P   =   0.7769). In @entity1 (n   =   188), the post-chemoprophylaxis @entity3 expansion proportion was 1.6% with chemoprophylaxis after day 3. The @entity4 proportions were as follows: chemoprophylaxis on days 1 to 3, 2.6% in 2,384 @entity0 ; chemoprophylaxis on days 4 or 5, 2.2% in 831; and chemoprophylaxis on day 8, 14.1% in 99 (P   <   0.0001). Spontaneous @entity3 expansion proportions at 24 hours substantially vary between chemoprophylaxis and non-chemoprophylaxis studies. Chemoprophylaxis should not be given within 3 days of injury for moderate-risk or high-risk @entity3 . Chemoprophylaxis is reasonable when low-risk @entity0 have not developed @entity3 expansion within 48 hours @entity2 . Chemoprophylaxis is also acceptable after day 3, when low-risk @entity0 develop @entity3 expansion within 48 hours @entity2 . In @entity1 @entity0 who have not developed @entity3 within 72 hours, chemoprophylaxis is reasonable. @entity4 proportions significantly increase when chemoprophylaxis is withheld for greater than 7 days.

title: Timing for XXXX in traumatic brain injury: an evidence-based review.

answer: @entity4


abstract: BACKGROUND: Different maternal psychological states during pregnancy have been associated with wheeze- @entity6 - @entity5 symptoms in @entity0 . However, previous studies were limited and it was unclear whether the type of prenatal psychological state was associated with a particular symptom. We examined the association of maternal @entity3 and @entity2 during pregnancy with wheeze- @entity6 - @entity5 symptoms in infancy. METHODS: In a longitudinal birth cohort (GUSTO) of 1152 mother- @entity0 pairs, wheeze- @entity6 - @entity5 symptoms in the @entity0 during the first year of life were collected by parental report. Maternal @entity3 and @entity2 symptoms were assessed at 26 weeks of gestation using the Edinburgh Postnatal Depression Scale (EPDS) and State Trait @entity2 Inventory (STAI). Logistic regression analyses were performed with adjustment for potential confounders. RESULTS: An increased risk of wheezing was found in @entity0 of pregnant @entity0 with probable @entity3 (EPDS >=  15) [odds ratio (OR) = 1.85 (95% confidence interval (CI) 1.10-3.12)], and an increased risk of @entity6 was associated with maternal @entity2 [STAI state >=  41: OR = 1.42 (95% CI 1.04-1.93); STAI trait >=  43: OR = 1.38 (95% CI 1.01-1.88)]. After adjusting for known risk factors for the development of @entity1 , these associations remained significant [EPDS >=  15: adjusted OR = 2.09 (95% CI 1.05-4.19); STAI state >=  41: adjusted OR = 1.82 (95% CI 1.17-2.82); STAI trait >=  43: adjusted OR = 1.70 (95% CI 1.10-2.61)]. However, maternal psychological states were not associated with @entity4 . CONCLUSION: This study suggests that there may be an independent effect of prenatal @entity3 on wheezing and @entity2 on @entity6 in infancy.

title: An independent association of prenatal XXXX with wheezing and @entity2 with @entity6 in infancy.

answer: @entity3


abstract: BACKGROUND: Different maternal psychological states during pregnancy have been associated with wheeze- @entity6 - @entity5 symptoms in @entity0 . However, previous studies were limited and it was unclear whether the type of prenatal psychological state was associated with a particular symptom. We examined the association of maternal @entity3 and @entity2 during pregnancy with wheeze- @entity6 - @entity5 symptoms in infancy. METHODS: In a longitudinal birth cohort (GUSTO) of 1152 mother- @entity0 pairs, wheeze- @entity6 - @entity5 symptoms in the @entity0 during the first year of life were collected by parental report. Maternal @entity3 and @entity2 symptoms were assessed at 26 weeks of gestation using the Edinburgh Postnatal Depression Scale (EPDS) and State Trait @entity2 Inventory (STAI). Logistic regression analyses were performed with adjustment for potential confounders. RESULTS: An increased risk of wheezing was found in @entity0 of pregnant @entity0 with probable @entity3 (EPDS >=  15) [odds ratio (OR) = 1.85 (95% confidence interval (CI) 1.10-3.12)], and an increased risk of @entity6 was associated with maternal @entity2 [STAI state >=  41: OR = 1.42 (95% CI 1.04-1.93); STAI trait >=  43: OR = 1.38 (95% CI 1.01-1.88)]. After adjusting for known risk factors for the development of @entity1 , these associations remained significant [EPDS >=  15: adjusted OR = 2.09 (95% CI 1.05-4.19); STAI state >=  41: adjusted OR = 1.82 (95% CI 1.17-2.82); STAI trait >=  43: adjusted OR = 1.70 (95% CI 1.10-2.61)]. However, maternal psychological states were not associated with @entity4 . CONCLUSION: This study suggests that there may be an independent effect of prenatal @entity3 on wheezing and @entity2 on @entity6 in infancy.

title: An independent association of prenatal @entity3 with wheezing and @entity2 with XXXX in infancy.

answer: @entity6


abstract: BACKGROUND: Different maternal psychological states during pregnancy have been associated with wheeze- @entity6 - @entity5 symptoms in @entity0 . However, previous studies were limited and it was unclear whether the type of prenatal psychological state was associated with a particular symptom. We examined the association of maternal @entity3 and @entity2 during pregnancy with wheeze- @entity6 - @entity5 symptoms in infancy. METHODS: In a longitudinal birth cohort (GUSTO) of 1152 mother- @entity0 pairs, wheeze- @entity6 - @entity5 symptoms in the @entity0 during the first year of life were collected by parental report. Maternal @entity3 and @entity2 symptoms were assessed at 26 weeks of gestation using the Edinburgh Postnatal Depression Scale (EPDS) and State Trait @entity2 Inventory (STAI). Logistic regression analyses were performed with adjustment for potential confounders. RESULTS: An increased risk of wheezing was found in @entity0 of pregnant @entity0 with probable @entity3 (EPDS >=  15) [odds ratio (OR) = 1.85 (95% confidence interval (CI) 1.10-3.12)], and an increased risk of @entity6 was associated with maternal @entity2 [STAI state >=  41: OR = 1.42 (95% CI 1.04-1.93); STAI trait >=  43: OR = 1.38 (95% CI 1.01-1.88)]. After adjusting for known risk factors for the development of @entity1 , these associations remained significant [EPDS >=  15: adjusted OR = 2.09 (95% CI 1.05-4.19); STAI state >=  41: adjusted OR = 1.82 (95% CI 1.17-2.82); STAI trait >=  43: adjusted OR = 1.70 (95% CI 1.10-2.61)]. However, maternal psychological states were not associated with @entity4 . CONCLUSION: This study suggests that there may be an independent effect of prenatal @entity3 on wheezing and @entity2 on @entity6 in infancy.

title: An independent association of prenatal @entity3 with wheezing and XXXX with @entity6 in infancy.

answer: @entity2


abstract: BACKGROUND: Multiple procedures have been described to treat a large-angle esodeviation with an associated abduction deficit. We report a plication augmentation of the Hummelsheim procedure for the management of @entity4 and severe abduction deficit due to @entity2 . METHODS: The medical records of @entity0 operated on using the plication augmentation Hummelsheim procedure at two tertiary centers were retrospectively reviewed. The surgery involved ipsilateral lateral rectus plication, half muscle transposition of the vertical rectus muscles to the paralytic plicated lateral rectus, Foster augmentation sutures, and ipsilateral medial rectus recession or botulinum toxin injection if it was found to be tight on intraoperative forced duction testing. Pre- and postoperative deviations, ocular motility findings, and complications were noted. RESULTS: A total of 13 @entity0 were included, all of whom had an @entity4 with profound abduction deficit (-4 or more). Postoperative deviations ranged from 14(  ) of @entity4 to 14(  ) of @entity3 , with significant improvement of the abductive motion. No @entity0 developed @entity1 . CONCLUSIONS: The plication augmentation Hummelsheim procedure resulted in correction of even very large esodeviations and improvement of the abduction force. This procedure may also better preserve the blood supply to the anterior segment compared to other surgical approaches.

title: Plication augmentation of the modified Hummelsheim procedure for treatment of large-angle @entity4 due to XXXX .

answer: @entity2


abstract: BACKGROUND: Multiple procedures have been described to treat a large-angle esodeviation with an associated abduction deficit. We report a plication augmentation of the Hummelsheim procedure for the management of @entity4 and severe abduction deficit due to @entity2 . METHODS: The medical records of @entity0 operated on using the plication augmentation Hummelsheim procedure at two tertiary centers were retrospectively reviewed. The surgery involved ipsilateral lateral rectus plication, half muscle transposition of the vertical rectus muscles to the paralytic plicated lateral rectus, Foster augmentation sutures, and ipsilateral medial rectus recession or botulinum toxin injection if it was found to be tight on intraoperative forced duction testing. Pre- and postoperative deviations, ocular motility findings, and complications were noted. RESULTS: A total of 13 @entity0 were included, all of whom had an @entity4 with profound abduction deficit (-4 or more). Postoperative deviations ranged from 14(  ) of @entity4 to 14(  ) of @entity3 , with significant improvement of the abductive motion. No @entity0 developed @entity1 . CONCLUSIONS: The plication augmentation Hummelsheim procedure resulted in correction of even very large esodeviations and improvement of the abduction force. This procedure may also better preserve the blood supply to the anterior segment compared to other surgical approaches.

title: Plication augmentation of the modified Hummelsheim procedure for treatment of large-angle XXXX due to @entity2 .

answer: @entity4


abstract: BACKGROUND: The @entity0 ( @entity0 ) is one of several sub-regional disease surveillance networks that have emerged in recent years as an approach to transnational cooperation for infectious disease prevention and control. Since 2003 @entity0 has pioneered a unique model for @entity1 . This study examines stakeholders' perspectives of these @entity0 experiences, based on a survey of local managers and semi-structured interviews with @entity0 leaders and the central coordinator. RESULTS: Fifteen managers from 12 of 20 paired @entity1 completed a written survey. They all monitor most or all of the 17 diseases agreed upon for @entity0 surveillance information sharing. Fourteen agreed or strongly agreed with statements about the core @entity0 values of cooperation, mutual trust, and transparency, and their own contributions to national and regional disease control (average score of 4.4 of 5.0). Respondents felt they implemented well to very well activities related to surveillance reporting (average scores 3.4 to 3.9 of 4.0), using computers for their work (3.9/4.0), and using surveillance data for action (3.8/4.0). Respondents reported that they did worst in implementing research (2.1/4.0) and somewhat poorly for local laboratory testing (2.9/4.0) and local coordination with cross-border counterparts (2.9/4.0), although all 15 maintain a list with contact information for these counterparts and many know their counterparts. Implementation of specified activities within their collective regional action plan was uneven across the @entity1 . Most respondents reported positive lessons learned about local cooperation, information sharing and joint problem solving, based on trusting relationships with their cross-border counterparts. They recommend expansion of @entity1 within @entity0 and consideration of the cross-border cooperation model by other sub-regional networks. CONCLUSIONS: @entity0 has over a decade of experience with its model of @entity1 in disease surveillance and control. Frontline managers have documented success with this model, strongly support it and recommend its expansion within and beyond the @entity0 network. The @entity0 cross-border cooperation model is standing the test of time as a solid approach to building and sustaining the public health capabilities needed for disease surveillance and control from the local to national and global levels.

title: Local XXXX surveillance and control: experiences from the Mekong Basin.

answer: @entity1


abstract: In 255 @entity0 with evidence of a @entity5 , 7 @entity0 presented with typical symptoms of @entity4 , which all proved to be sterile. In these @entity0 a @entity5 was surgically verified in 4. In one @entity0 the presence of @entity6 indicated a @entity5 . In 2 @entity0 an enlarged, @entity8 was found, taken to reflect spontaneous disappearance of an @entity3 . It is thought that the cause of the sterile meningeal reaction in the 7 @entity0 was a spontaneous @entity1 of the @entity3 with expulsion of necrotic material into the suprasellar subarachnoid space. Although this sequence has been described before it has been considered to occur very rarely. @entity7 as the underlying cause of @entity4 should be suspected in @entity0 with evidence of @entity9 or lesion of structures adjacent to the fossa. The diagnosis may be established by computer tomography. Therapeutically, it may be of importance that the nature of the meningeal reaction is promptly recognized. @entity2 neurosurgical decompression of the sella and adequate hormonal substitution therapy may be essential.

title: XXXX with @entity4 .

answer: @entity7


abstract: In 255 @entity0 with evidence of a @entity5 , 7 @entity0 presented with typical symptoms of @entity4 , which all proved to be sterile. In these @entity0 a @entity5 was surgically verified in 4. In one @entity0 the presence of @entity6 indicated a @entity5 . In 2 @entity0 an enlarged, @entity8 was found, taken to reflect spontaneous disappearance of an @entity3 . It is thought that the cause of the sterile meningeal reaction in the 7 @entity0 was a spontaneous @entity1 of the @entity3 with expulsion of necrotic material into the suprasellar subarachnoid space. Although this sequence has been described before it has been considered to occur very rarely. @entity7 as the underlying cause of @entity4 should be suspected in @entity0 with evidence of @entity9 or lesion of structures adjacent to the fossa. The diagnosis may be established by computer tomography. Therapeutically, it may be of importance that the nature of the meningeal reaction is promptly recognized. @entity2 neurosurgical decompression of the sella and adequate hormonal substitution therapy may be essential.

title: @entity7 with XXXX .

answer: @entity4


abstract: Penile duplex Doppler ultrasound (PDDU) assesses the etiology of @entity1 . Peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) are common PDDU parameters. We assessed whether stretched penile length (SPL) in the flaccid state and measured penile length at peak erection after intracavernosal injection (ICI) of a vasodilator during PDDU correlated with the etiology of @entity1 . We performed a retrospective review of 93 @entity0 who underwent PDDU for @entity1 . Normal and stretched penile length were measured, both at a flaccid state prior to ICI and at peak erection during PDDU. Collected data included @entity0 demographics, vascular, and anatomic parameters. The mean age was 52  years. SPL was equivalent to peak penile length after ICI in 60 @entity0 (65%, group 1) and did not match in 33 (35%, group 2). There were no significant differences between the two groups in terms of flaccid, stretched, and post-ICI erect penile lengths, IIEF score, PSV, percent @entity2 or tumescence, and vasodilator dose used. @entity0 in group 2 had less of a change in penile length from flaccid to erect state (36% vs. 44%, p  =  0.02), higher EDV (12.0 vs. 8.5, p  =  0.041), lower RI (0.6 vs. 1.0, p  =  0.046), and more @entity4 (82% vs. 53%, p  =  0.001). On multivariate analysis, failure to reach maximum SPL at peak ICI erection (OR 2.255, CI 1.191-4.271, p  =  0.0126), EDV (OR 1.281, CI 1.115-1.471, p  <  0.001) and RI (OR 0.694, CI 0.573-0.723, p  =  0.009) predicted @entity4 . Failure to reach maximal SPL during PDDU using ICI with a vasodilator agent predicted @entity4 , which is independent of both @entity2 and tumescence. This measurement could serve as another diagnostic tool for predicting @entity4 when PDDU is not readily available. Limitations include the subjective nature of penile measurements and different @entity3 doses used.

title: Failure to attain stretched penile length after intracavernosal injection of a vasodilator agent is predictive of XXXX on penile duplex Doppler ultrasonography.

answer: @entity4


abstract: UNASSIGNED: Polymer microparticles used for drug encapsulation and delivery have various surface morphologies depending on the type of formulation ingredients and parameters of the manufacture process. This works aims at investigating the critical parameters governing the morphology of microparticles and to underline the influence of their surface state on the drug release. The classical fabrication process by the "emulsion-solvent evaporation" is addressed using @entity2 as the polymer and @entity0 as the volatile organic solvent. The typical surfactants @entity3 and @entity4 80 have been considered. Scanning electron microscopy observations showed the various surface morphologies mainly depending on the stirring rate, the viscosity of the oil phase and by the presence of inappropriate surfactants. Because of arrested coalescence during solvent evaporation, the evaporation of the organic solvent causing particles hardening is the most important parameter that controls the morphology. Indeed, slow evaporation allows partial coalescence of the soft particles swollen by the organic solvent, whereas the particles morphology is frozen rapidly upon fast evaporation, thus preventing damaged surface states. Moreover, an effective stabilizing system for the primary emulsion is also a determining factor to control the final morphology. The morphology of the particles has a definite influence on the drug delivery of @entity1 . The surface morphology should be taken into consideration in the design of polymer microparticles because it allows a control over the drug release kinetics.

title: The parameters influencing the morphology of XXXX microspheres and the resulting release of encapsulated drugs.

answer: @entity2


abstract: BACKGROUND: Primary @entity3 (ASC) is a rare subset of ASC. This study aims to investigate the clinicopathological features, diagnosis, treatment, and outcomes of primary gastric ASC. METHODS: The medical records of 13 consecutive @entity0 with primary gastric ASC between January 2010 and July 2014 from a single institutional database were reviewed. RESULTS: Male predominance was observed (M/F = 10/3) among the @entity0 , and their median age was 62 years (range: 43 to 79 years). The primary lesions were most often found in the upper third of the stomach, with a median @entity2 size of 5 cm (range: 2.25 cm to 10.5 cm). Ten @entity0 underwent radical resections (R0 resection, 76.9%), while three @entity0 had palliative resections (R1/R2 resection, 23.1%). Twelve @entity0 had lymph node @entity1 at the time of surgery. @entity4 and @entity5 components in lymph node were found in eight and two cases, respectively, while two @entity0 had both @entity5 and @entity4 components. In terms of the TNM staging system, stages IIB, IIIA, IIIB, IIIC, and IV were detected in 2 (15.4%), 2 (15.4%), 1 (7.7%), 5 (38.5%), and 3 (23.1%) @entity0 , respectively. The median follow-up period was 22 months (range: 5 to 52 months); during which, four @entity0 were still alive and eight @entity0 died because of @entity2 progression. The 1-, 2-, and 3-year survival rates were 76.9%, 46.2%, and 15.4%, respectively. CONCLUSIONS: Primary gastric ASC has a very poor prognosis, and both @entity5 and @entity4 components have distant @entity1 potential.

title: Clinicopathological characteristics, diagnosis, treatment, and outcomes of primary XXXX .

answer: @entity3


abstract: INTRODUCTION: Elevated type I interferon (IFN) response gene (IRG) expression has proven clinical relevance in predicting rituximab non-response in @entity2 ( @entity2 ). Interference between glucocorticoids (GCs) and type I IFN signaling has been demonstrated in vitro. Since GC use and dose are highly variable among @entity0 before rituximab treatment, the aim of this study was to determine the effect of GC use on IRG expression in relation to rituximab response prediction in @entity2 . METHODS: In two independent cohorts of 32 and 182 biologic-free @entity2 @entity0 and a third cohort of 40 rituximab-starting @entity2 @entity0 , peripheral blood expression of selected IRGs was determined by microarray or quantitative real-time polymerase chain reaction (qPCR), and an IFN-score was calculated. The baseline IFN-score was tested for its predictive value towards rituximab response in relation to GC use using receiver operating characteristics (ROC) analysis in the rituximab cohort. @entity0 with a decrease in disease activity score (   DAS28) >1.2 after 6  months of rituximab were considered responders. RESULTS: We consistently observed suppression of IFN-score in @entity1 users (PREDN(+)) compared to non-users (PREDN(-)). In the rituximab cohort, analysis on PREDN(-) @entity0 (n   =   13) alone revealed improved prediction of rituximab non-response based on baseline IFN-score, with an area under the curve (AUC) of 0.975 compared to 0.848 in all @entity0 (n   =   40). Using a group-specific IFN-score cut-off for all @entity0 and PREDN(-) @entity0 alone, sensitivity increased from 41% to 88%, respectively, combined with 100% specificity. CONCLUSIONS: Because of @entity1 -related suppression of IFN-score, higher accuracy of rituximab response prediction was achieved in PREDN(-) @entity0 . These results suggest that the IFN-score-based rituximab response prediction model could be improved upon implementation of @entity1 use.

title: Effect of XXXX on type I interferon signature in @entity2 : consequences for response prediction to rituximab.

answer: @entity1


abstract: INTRODUCTION: Elevated type I interferon (IFN) response gene (IRG) expression has proven clinical relevance in predicting rituximab non-response in @entity2 ( @entity2 ). Interference between glucocorticoids (GCs) and type I IFN signaling has been demonstrated in vitro. Since GC use and dose are highly variable among @entity0 before rituximab treatment, the aim of this study was to determine the effect of GC use on IRG expression in relation to rituximab response prediction in @entity2 . METHODS: In two independent cohorts of 32 and 182 biologic-free @entity2 @entity0 and a third cohort of 40 rituximab-starting @entity2 @entity0 , peripheral blood expression of selected IRGs was determined by microarray or quantitative real-time polymerase chain reaction (qPCR), and an IFN-score was calculated. The baseline IFN-score was tested for its predictive value towards rituximab response in relation to GC use using receiver operating characteristics (ROC) analysis in the rituximab cohort. @entity0 with a decrease in disease activity score (   DAS28) >1.2 after 6  months of rituximab were considered responders. RESULTS: We consistently observed suppression of IFN-score in @entity1 users (PREDN(+)) compared to non-users (PREDN(-)). In the rituximab cohort, analysis on PREDN(-) @entity0 (n   =   13) alone revealed improved prediction of rituximab non-response based on baseline IFN-score, with an area under the curve (AUC) of 0.975 compared to 0.848 in all @entity0 (n   =   40). Using a group-specific IFN-score cut-off for all @entity0 and PREDN(-) @entity0 alone, sensitivity increased from 41% to 88%, respectively, combined with 100% specificity. CONCLUSIONS: Because of @entity1 -related suppression of IFN-score, higher accuracy of rituximab response prediction was achieved in PREDN(-) @entity0 . These results suggest that the IFN-score-based rituximab response prediction model could be improved upon implementation of @entity1 use.

title: Effect of @entity1 on type I interferon signature in XXXX : consequences for response prediction to rituximab.

answer: @entity2


abstract: Isolated metachronous gastrointestinal metastases from @entity2 are rarely diagnosed on the basis of symptoms and resected. In this report, we present a case of resectable @entity6 and small intestinal metastases of @entity1 . An 86-year-old @entity0 was treated for @entity1 with resection of the right inferior lobe. Five months after the surgery, she was re-admitted because of @entity5 and @entity4 . Ultrasonography showed a @entity7 with @entity3 , and laparoscopic-assisted cholecystectomy was subsequently performed. However, 2  months after this event, the @entity0 presented again with @entity5 and @entity4 and was diagnosed with a small @entity8 . Therefore, laparoscopic-assisted partial resection of the small intestine was performed. Immunohistochemical staining for @entity10 and @entity9 confirmed that the two resected @entity2 were metachronous metastases of the primary @entity1 . The @entity0 died of liver metastases 5  months after the last surgery. Our experience with this case suggests that surgical resection might not be curative but palliative for @entity0 with @entity6 and small intestinal metastases diagnosed on the basis of @entity5 that is resistant to conservative treatment.

title: Usefulness of immunohistochemical studies in diagnosing XXXX and small intestinal metastases from @entity1 with @entity3 : a case report.

answer: @entity6


abstract: Isolated metachronous gastrointestinal metastases from @entity2 are rarely diagnosed on the basis of symptoms and resected. In this report, we present a case of resectable @entity6 and small intestinal metastases of @entity1 . An 86-year-old @entity0 was treated for @entity1 with resection of the right inferior lobe. Five months after the surgery, she was re-admitted because of @entity5 and @entity4 . Ultrasonography showed a @entity7 with @entity3 , and laparoscopic-assisted cholecystectomy was subsequently performed. However, 2  months after this event, the @entity0 presented again with @entity5 and @entity4 and was diagnosed with a small @entity8 . Therefore, laparoscopic-assisted partial resection of the small intestine was performed. Immunohistochemical staining for @entity10 and @entity9 confirmed that the two resected @entity2 were metachronous metastases of the primary @entity1 . The @entity0 died of liver metastases 5  months after the last surgery. Our experience with this case suggests that surgical resection might not be curative but palliative for @entity0 with @entity6 and small intestinal metastases diagnosed on the basis of @entity5 that is resistant to conservative treatment.

title: Usefulness of immunohistochemical studies in diagnosing @entity6 and small intestinal metastases from XXXX with @entity3 : a case report.

answer: @entity1


abstract: Isolated metachronous gastrointestinal metastases from @entity2 are rarely diagnosed on the basis of symptoms and resected. In this report, we present a case of resectable @entity6 and small intestinal metastases of @entity1 . An 86-year-old @entity0 was treated for @entity1 with resection of the right inferior lobe. Five months after the surgery, she was re-admitted because of @entity5 and @entity4 . Ultrasonography showed a @entity7 with @entity3 , and laparoscopic-assisted cholecystectomy was subsequently performed. However, 2  months after this event, the @entity0 presented again with @entity5 and @entity4 and was diagnosed with a small @entity8 . Therefore, laparoscopic-assisted partial resection of the small intestine was performed. Immunohistochemical staining for @entity10 and @entity9 confirmed that the two resected @entity2 were metachronous metastases of the primary @entity1 . The @entity0 died of liver metastases 5  months after the last surgery. Our experience with this case suggests that surgical resection might not be curative but palliative for @entity0 with @entity6 and small intestinal metastases diagnosed on the basis of @entity5 that is resistant to conservative treatment.

title: Usefulness of immunohistochemical studies in diagnosing @entity6 and small intestinal metastases from @entity1 with XXXX : a case report.

answer: @entity3


abstract: INTRODUCTION: The presence of a new autoantibody system, anti-carbamylated protein (anti- @entity4 ) antibodies, has been identified in @entity1 ( @entity1 ). The presence of anti- @entity4 antibodies was evaluated in samples taken from individuals who subsequently developed @entity1 before and after onset of symptoms and related to previously analysed antibodies against citrullinated peptides ( @entity2 specificities) and anti- @entity3 . METHODS: A total of 252 individuals, with 423 samples from before onset of symptoms of @entity1 , and 197 population controls were identified as donors to the Medical Biobank of Northern Sweden; 192 of them were also sampled at the time of diagnosis. All samples were analysed for anti- @entity4 IgG and anti- @entity3 antibodies using ELISAs. Ten different antibody reactivities against citrullinated antigens ( @entity2 specificities) were analysed using a custom-made microarray based on the ImmunoCAP ISAC system (Phadia). RESULTS: The concentration of anti- @entity4 antibodies was significantly increased in the pre-symptomatic individuals compared with controls (P<0.001) and also increased significantly after disease onset (P<0.001). The sensitivity for anti- @entity4 antibodies in the pre-symptomatic individuals was 13.9% (95% CI: 11 to 17.6) and 42.2% (95% CI: 35.4 to 49.3) following development of @entity1 . Anti- @entity4 antibody positivity was found in 5.1% to 13.3% of individuals negative for anti- @entity3 or @entity2 specificities. Presence of anti- @entity4 antibodies was significantly related to radiological destruction at baseline, at 24 months and also to radiological change (P<0.05, all). CONCLUSIONS: The results indicate that anti- @entity4 antibodies are associated with disease development, even after adjusting for the presence of different @entity2 fine specificities, and in anti- @entity3 negative individuals and contribute to the identification of a subset of @entity0 with worse radiological progression of the disease independent of @entity2 .

title: Anti-carbamylated protein antibodies in the pre-symptomatic phase of XXXX , their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage.

answer: @entity1


abstract: INTRODUCTION: Correct target positioning is crucial for accurate dose delivery in breast radiotherapy resulting in utilisation of daily imaging. However, the radiation dose from daily imaging is associated with increased probability of secondary induced @entity2 . The aim of this study was to quantify doses associated with three imaging modalities and investigate the correlation of dose and varying breast size in breast radiotherapy. METHODS: Planning computed tomography (CT) data sets of 30 @entity0 @entity1 were utilised to simulate the dose received by various organs from a megavoltage computed tomography (MV-CT), megavoltage electronic portal image (MV-EPI) and megavoltage cone-beam computed tomography (MV-CBCT). The mean dose to organs adjacent to the target volume (contralateral breast, lungs, spinal cord and heart) were analysed. Pearson correlation analysis was performed to determine the relationship between imaging dose and primary breast volume and the lifetime attributable risk (LAR) of induced secondary @entity2 was calculated for the contralateral breast. RESULTS: The highest contralateral breast mean dose was from the MV-CBCT (1.79  Gy), followed by MV-EPI (0.22  Gy) and MV-CT (0.11  Gy). A similar trend was found for all organs at risk (OAR) analysed. The primary breast volume inversely correlated with the contralateral breast dose for all three imaging modalities. As the primary breast volume increases, the likelihood of a @entity1 developing a radiation-induced secondary @entity2 to the contralateral breast decreases. MV-CBCT showed a stronger relationship between breast size and LAR of developing a radiation-induced @entity0 in comparison with the MV-CT and MV-EPI. CONCLUSIONS: For breast @entity1 , imaging dose to OAR depends on imaging modality and treated breast size. When considering the use of imaging during breast radiotherapy, the @entity1 's breast size and contralateral breast dose should be taken into account.

title: Imaging dose in breast radiotherapy: does breast size affect the dose to the organs at risk and the risk of secondary XXXX to the contralateral breast?

answer: @entity2


abstract: BACKGROUND: Totally laparoscopic distal gastrectomy (TLDG) has been developed in the hope of improving surgical quality and overcoming the limitations of conventional laparoscopic assisted distal gastrectomy (LADG) for @entity3 . The aim of this study was to determine the extent of evidence in support of these ideals. METHODS: A systematic review of the two operation types (LADG and TLDG) was carried out to evaluate short-term outcomes including duration of operation, retrieved lymph nodes, estimated @entity1 , resection margin status, technical @entity2 , and hospital stay. RESULTS: Twelve non-randomized observational clinical studies involving 2,255 @entity0 satisfied the eligibility criteria. Operative time was not statistically different between groups (P > 0.05). The number of retrieved lymph nodes and the resection margin length in TLDG were comparable with those in LADG. Estimated @entity1 was significantly less in TLDG than that in @entity4 (P < 0.01). Compared to LADG, TLDG also involved lesser postoperative hospital stay (P < 0.01) and earlier time to soft diet intake (P < 0.05). Time to flatus and @entity2 were similar for those two operative approaches. CONCLUSIONS: TLDG may be a technically safe, feasible, and favorable approach in terms of better cosmesis, less @entity1 , and faster recovery compared with LADG.

title: Systematic review and meta-analysis of totally laparoscopic versus laparoscopic assisted distal gastrectomy for XXXX .

answer: @entity3


abstract: BACKGROUND: Excessive mechanical loading of articular cartilage producing hydrostatic stress, tensile strain and fluid flow leads to irreversible @entity4 . Since application of high fluid shear to chondrocytes recapitulates some of the earmarks of OA, we aimed to screen the gene expression profiles of shear-activated chondrocytes and assess potential similarities with OA chondrocytes. METHODOLOGY/PRINCIPAL FINDINGS: Using a cDNA microarray technology, we screened the differentially-regulated genes in @entity0 T/C-28a2 chondrocytes subjected to high fluid shear (20 dyn/cm(2)) for 48 h and 72 h relative to static controls. Confirmation of the expression patterns of select genes was obtained by qRT-PCR. Using significance analysis of microarrays with a 5% false discovery rate, 71 and 60 non-redundant transcripts were identified to be >= 2-fold up-regulated and  <=0.6-fold down-regulated, respectively, in sheared chondrocytes. Published data sets indicate that 42 of these genes, which are related to extracellular matrix/degradation, cell proliferation/differentiation, @entity2 and cell survival/death, are differentially-regulated in OA chondrocytes. In view of the pivotal role of @entity5 ( @entity5 ) in the pathogenesis and/or progression of OA in vivo and regulation of shear-induced @entity2 and apoptosis in vitro, we identified a collection of genes that are either up- or down-regulated by shear-induced @entity5 . @entity5 and @entity6 ( @entity6 ) induce reactive @entity1 species production, and negatively regulate genes of the histone and cell cycle families, which may play a critical role in chondrocyte death. CONCLUSIONS/SIGNIFICANCE: Prolonged application of high fluid shear stress to chondrocytes recapitulates gene expression profiles associated with @entity3 . Our data suggest a potential link between exposure of chondrocytes/cartilage to abnormal mechanical loading and the pathogenesis/progression of OA.

title: Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with XXXX .

answer: @entity3


abstract: BACKGROUND: The management for @entity3 with @entity6 remains controversial. Reduction of lumbar spondylolisthesis has been performed via numerous techniques. Most of them need extra reduction assembly. METHODS: In this retrospective analysis, 27 @entity0 of @entity3 with @entity6 underwent reduction using polyaxial screw and rod constructs and posterolateral fusion. The average age at the time of surgery was 53        3.23  years. The outcome measures consisted of a radiographic assessment of deformity and fusion rate and a clinical assessment of perioperative improvement in @entity9 and function. Preoperative and postoperative radiographic evaluation included the percent slip, slip angle, and the lumbar @entity8 between L1 and the sacrum measured using the Cobb method. Before surgery and at the final follow-up, the @entity7 Index (ODI) and the @entity5 analog scale (VPAS) between 0 (no @entity2 ) and 10 ( @entity2 ) were quantified. RESULTS: The average follow-up period more than 5  years was available. The mean operative time was 90.19        14.51  min, and the mean @entity4 during surgery was 152.59        45.71  ml. The mean length of incision was 4.83        0.63  cm. The average percent slippage and the mean slip angle were, respectively, 19.8        4.49% and 9.69        3.79   before surgery, 5.09        3.40% and 6.39        3.16   after surgery, and 5.67        3.92% and 7.21        3.05   at the last follow-up. The average lumbar @entity8 was 36.88        2.64   before surgery, 41.96        1.64   after surgery, and 40.27        1.19   at the final follow-up. No @entity1 occurred. Solid fusion was achieved for all cases. Compared with the outcome preoperation, the data improved from 6.56        1.40 to 2.48        1.16 for VPAS @entity2 scores and from 32.22        3.57 to 10.93        4.93 for the ODI at the final follow-up. CONCLUSIONS: Lever slip reduction maneuver techniques using polyaxial screw and rod fixation system was simple and practicable. The treatment outcomes showed satisfactory radiographic characteristics and clinical results. The length of the incision was relatively small with a low intraoperative @entity4 and short operation time.

title: Lever reduction using polyaxial screw and rod fixation system for the treatment of XXXX with @entity6 : technique and clinical outcome.

answer: @entity3


abstract: BACKGROUND: The management for @entity3 with @entity6 remains controversial. Reduction of lumbar spondylolisthesis has been performed via numerous techniques. Most of them need extra reduction assembly. METHODS: In this retrospective analysis, 27 @entity0 of @entity3 with @entity6 underwent reduction using polyaxial screw and rod constructs and posterolateral fusion. The average age at the time of surgery was 53        3.23  years. The outcome measures consisted of a radiographic assessment of deformity and fusion rate and a clinical assessment of perioperative improvement in @entity9 and function. Preoperative and postoperative radiographic evaluation included the percent slip, slip angle, and the lumbar @entity8 between L1 and the sacrum measured using the Cobb method. Before surgery and at the final follow-up, the @entity7 Index (ODI) and the @entity5 analog scale (VPAS) between 0 (no @entity2 ) and 10 ( @entity2 ) were quantified. RESULTS: The average follow-up period more than 5  years was available. The mean operative time was 90.19        14.51  min, and the mean @entity4 during surgery was 152.59        45.71  ml. The mean length of incision was 4.83        0.63  cm. The average percent slippage and the mean slip angle were, respectively, 19.8        4.49% and 9.69        3.79   before surgery, 5.09        3.40% and 6.39        3.16   after surgery, and 5.67        3.92% and 7.21        3.05   at the last follow-up. The average lumbar @entity8 was 36.88        2.64   before surgery, 41.96        1.64   after surgery, and 40.27        1.19   at the final follow-up. No @entity1 occurred. Solid fusion was achieved for all cases. Compared with the outcome preoperation, the data improved from 6.56        1.40 to 2.48        1.16 for VPAS @entity2 scores and from 32.22        3.57 to 10.93        4.93 for the ODI at the final follow-up. CONCLUSIONS: Lever slip reduction maneuver techniques using polyaxial screw and rod fixation system was simple and practicable. The treatment outcomes showed satisfactory radiographic characteristics and clinical results. The length of the incision was relatively small with a low intraoperative @entity4 and short operation time.

title: Lever reduction using polyaxial screw and rod fixation system for the treatment of @entity3 with XXXX : technique and clinical outcome.

answer: @entity6


abstract: UNASSIGNED: A sensory stimulus can only be properly interpreted in light of the stimuli that surround it in space and time. The @entity1 ( @entity1 ) and tilt after-effect (TAE) provide good evidence that the perception of a target depends strongly on both its spatial and temporal context. In previous studies, the @entity1 and TAE have typically been investigated separately, so little is known about their co-effects on visual perception and information processing mechanisms. Here, we considered the influence of the spatial context and the temporal effect together and asked how center-surround context affects the TAE in foveal and @entity0 . Our results showed that different center-surround spatial patterns significantly affected the TAE for both foveal and @entity0 . In the fovea, the TAE was mainly produced by central adaptive gratings. Cross-oriented surroundings significantly inhibited the TAE, and iso-oriented surroundings slightly facilitated it; surround inhibition was much stronger than surround facilitation. In the para-fovea, the TAE was mainly decided by the surrounding patches. Likewise, a cross-oriented central patch inhibited the TAE, and an iso-oriented one facilitated it, but there was no significant difference between inhibition and facilitation. Our findings demonstrated, at the perceptual level, that our visual system adopts different mechanisms to process consistent or inconsistent central-surround orientation information and that the unequal magnitude of surround inhibition and facilitation is vitally important for the visual system to improve the detectability or discriminability of novel or incongruent stimuli.

title: Contextual influence on the tilt after-effect in foveal and XXXX .

answer: @entity0


abstract: UNASSIGNED: Topical corticosteroids (CSs) are the mainstay of treatment for @entity1 but @entity2 and fears are prevalent and influence therapeutic efficacy. AIM: To quantify if CS acceptability and fear affect @entity0 ' quality-of-life (QoL). METHODS: @entity0 with @entity1 managed in the pediatric dermatology outpatient clinic of a university hospital were surveyed. Nottingham Eczema Severity Score (NESS) for severity, @entity0 's Dermatology Life Quality Index (CDLQI) for QoL, CS fear, acceptability and reported frequency of CS use were measured with quantified questions. RESULTS: CS fears were prevalent among parents and caregivers of @entity0 with @entity1 . Fifty-eight percent of parents reported general acceptability of CS as being very good or good, and many applied CS to their @entity0 regularly every week. However, >40% of parents reported CS fear "always" or "often", 41% reported that they "always" or "often" apply CS only when @entity1 got worse, 57% would discuss CS fear with their doctors, 30% would request CS-sparing medications and 14% "always" or "often" use traditional Chinese herbal medicine. Fears were predominantly interpersonal and less often iatrogenic in nature. Skin problems were the most concerned side effects of CS. CS acceptability, frequency of CS usage, CS fear and usage of alternative medications were independent domains in @entity1 management: CS fears correlated with CDLQI; CS usage frequency correlated with NESS and negatively with parental education; and CS acceptability correlated with parental education. Ordinal logistic regressions showed worse QoL was associated with more CS fear (odds ratio: 1.092 [95% CI: 1.023-1.165], p   =   0.008). CONCLUSIONS: The extent of CS fears is independent of CS acceptability, but correlates with @entity0 ' QoL. Desensitization of parental CS fears should be integral part of @entity1 education and therapeutics in order to improve therapeutic efficacy and @entity0 ' QoL.

title: Correlations among steroid fear, acceptability, usage frequency, quality of life and disease severity in childhood XXXX .

answer: @entity1


abstract: OBJECTIVE: To analyze the results from arthroscopic suturing of large and extensive @entity2 , according to the @entity0 's degree of @entity3 . METHOD: 138 @entity0 who underwent arthroscopic suturing of large and extensive @entity2 between 2003 and 2011 were analyzed. Those operated from October 2008 onwards formed a prospective cohort, while the remainder formed a retrospective cohort. Also from October 2008 onwards, bone densitometry evaluation was requested at the time of the surgical treatment. For the @entity0 operated before this date, densitometry examinations performed up to two years before or after the surgical treatment were investigated. The @entity0 were divided into three groups. Those with @entity1 formed group 1 (n  =  16); those with @entity3 , group 2 (n  =  33); and normal individuals, group 3 (n  =  55). RESULTS: In analyzing the University of California at Los Angeles (UCLA) scores of group 3 and comparing them with group 2, no statistically significant difference was seen (p  =  0.070). Analysis on group 3 in comparison with group 1 showed a statistically significant difference (p  =  0.027). CONCLUSION: The results from arthroscopic suturing of large and extensive @entity2 seem to be influenced by the @entity0 's bone mineral density, as assessed using bone densitometry.

title: Comparative analysis on arthroscopic sutures of large and extensive @entity2 in relation to the degree of XXXX .

answer: @entity3


abstract: OBJECTIVE: To analyze the results from arthroscopic suturing of large and extensive @entity2 , according to the @entity0 's degree of @entity3 . METHOD: 138 @entity0 who underwent arthroscopic suturing of large and extensive @entity2 between 2003 and 2011 were analyzed. Those operated from October 2008 onwards formed a prospective cohort, while the remainder formed a retrospective cohort. Also from October 2008 onwards, bone densitometry evaluation was requested at the time of the surgical treatment. For the @entity0 operated before this date, densitometry examinations performed up to two years before or after the surgical treatment were investigated. The @entity0 were divided into three groups. Those with @entity1 formed group 1 (n  =  16); those with @entity3 , group 2 (n  =  33); and normal individuals, group 3 (n  =  55). RESULTS: In analyzing the University of California at Los Angeles (UCLA) scores of group 3 and comparing them with group 2, no statistically significant difference was seen (p  =  0.070). Analysis on group 3 in comparison with group 1 showed a statistically significant difference (p  =  0.027). CONCLUSION: The results from arthroscopic suturing of large and extensive @entity2 seem to be influenced by the @entity0 's bone mineral density, as assessed using bone densitometry.

title: Comparative analysis on arthroscopic sutures of large and extensive XXXX in relation to the degree of @entity3 .

answer: @entity2


abstract: BACKGROUND: Providing health services to an ageing population is challenging, and in rural areas even more so. It is expensive to provide high quality services to small populations who are widely dispersed; staff and @entity0 are often required to travel considerable distances to access services, and the economic downturn has created a climate where delivery costs are under constant review. There is potential for technology to overcome some of these problems by decreasing or ceasing the need for @entity0 and health professionals to travel to attend/deliver in- @entity0 appointments. A variety of eHealth initiatives (for example Pathways through @entity1 an online course aimed to aid self-help amongst those living with persistent @entity1 ) have been launched across the UK, but roll out remains at an early stage. METHODS: This mixed-methods study of older adults with @entity2 examines attitudes towards, current use of and acceptance of the use of technology in healthcare. A survey (n   =   168, 40% response rate) captured broad experiences of the use of technology in health and social care. Semi-structured interviews (four with technology and seven without technology @entity0 ) elicited attitudes towards technology in healthcare and explored attributes of personal and social interaction during home visits. RESULTS: @entity0 suffering from @entity2 access healthcare in a variety of ways. eHealth technology use was most common amongst older adults who lived alone. There was broad acceptance of eHealth being used in future care of @entity0 with @entity2 , but older adults wanted eHealth to be delivered alongside existing in- @entity0 visits from health and social care professionals. CONCLUSIONS: eHealth has the potential to overcome some traditional challenges of providing rural healthcare, however roll out needs to be gradual and begin by supplementing, not substituting, existing care and should be mindful of individual's circumstances, capability and preferences. Acceptance of technology may relate to existing levels of personal and social contact, and may be greater where technological help is not perceived to be replacing in- @entity0 care.

title: Attitudes towards the use and acceptance of eHealth technologies: a case study of older adults living with XXXX and implications for rural healthcare.

answer: @entity2


abstract: BACKGROUND: Normal function of the upper limb is seldom restored after limb-sparing surgery for @entity1 of the proximal humerus. The literature suggests superior shoulder function is achieved in the short term with reverse total shoulder arthroplasty compared to other techniques when performed for conditions with rotator cuff deficiency. It is unclear whether this superiority is maintained when reverse total shoulder arthroplasty is performed for @entity1 . QUESTIONS/PURPOSES: When performed for @entity1 , we determined whether reverse total shoulder arthroplasty restores function and improves motion, the complications associated with the surgery, and whether reverse total shoulder arthroplasty with autologous grafting is associated with bone resorption. @entity0 AND METHODS: We retrospectively reviewed 14 @entity0 who had undergone reverse total shoulder arthroplasty for @entity1 of the proximal humerus. Four @entity0 died, leaving nine @entity0 for review. The surviving @entity0 were evaluated clinically and radiographically. The minimum followup was 0.6 years (mean, 7.7 years; range, 0.6-12 years). RESULTS: At last followup, mean active abduction was 157   and mean functional Constant-Murley score was 76%. One @entity0 had a @entity2 and one developed a loose prosthesis; both were treated with single-stage exchange. At last followup, both @entity0 had reasonable function without evidence of @entity2 or loosening. Radiographic graft resorption was seen in all but one @entity0 . CONCLUSIONS: Our observations suggest, at medium-term followup, reverse total shoulder arthroplasty is a reasonable option for @entity1 of the proximal humerus. It has low morbidity, restores a mean active abduction of 157  , and limits the impairment of activities of daily living. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

title: Does reverse shoulder arthroplasty for XXXX of the proximal humerus reduce impairment?

answer: @entity1


abstract: INTRODUCTION: Follicular fluid is important for follicular development and oocyte maturation. Evidence suggests that follicular fluid is not only rich in proteins but cells. Besides oocytes, the follicular fluid contains granulosa, thecal, and ovarian surface epithelial cells, and both granulosa and thecal cells are well-characterized. However, epithelial cells in follicular fluid are poorly studied. This study aims to isolate and characterize in vitro epithelial cells that originate from @entity0 ovarian follicular fluid retrieved in the assisted fertilization program. METHODS: Follicular fluid samples were collected from 20 @entity0 in the assisted reproduction program. Epithelial cells were characterized by flow cytometry assay, immunofluorescence staining, real-time PCR, and time lapse photography. RESULTS: Epithelial cell cultures were established from 18 samples. A small population of epithelial cells expresses germ-line stem cell markers, such as @entity5 ( @entity5 ), @entity3 , and @entity10 ( @entity10 ). In the epithelial cell culture system, oocyte-like cells formed spontaneously in vitro and expressed the following transcription markers: deleted in @entity4 -like ( @entity9 ), developmental pluripotency associated protein 3 @entity8 -related protein ( @entity8 ), zona pellucida gene family C (ZPC), @entity6 ( @entity6 ), and @entity7 ( @entity7 ). Some of the oocyte-like cells developed a zona pellucida-like structure. Both the symmetric and asymmetric division split of epithelial cells and early developing oocytes were observed using time lapse photography. Cell colonies were formed during epithelial culturing, which maintained and proliferated in an undifferentiated way on the feeder layer and expressed some pluripotency markers. These colonies differentiated in vitro into various somatic cell types in all three germ layers, but did not form @entity2 when injected into immunodeficient @entity1 . Furthermore, these epithelial cells could be differentiated directly to functional hepatocyte-like cells, which do not exist in ovarian tissues. CONCLUSIONS: The epithelial cells derived from follicular fluid are a potential stem cell source with a pluripotent/multipotent character for safe application in oogenesis and regenerative medicine.

title: Identification and characterization of epithelial cells derived from XXXX ovarian follicular fluid.

answer: @entity0


abstract: @entity3 is a common @entity1 of childhood but is a rare occurrence in individuals over 20 years of age. Few cases are reported as originating from peripheral nerves. We present an unusual case of extraosseous @entity3 originating from the sciatic nerve in a 66-year-old @entity0 which had the clinical hallmarks of a @entity1 . Following discussion at a multidisciplinary meeting, excision biopsy of the suspected @entity1 was planned. At operation, the mass had malignant features. Histology confirmed the presence of @entity3 . Due to the morbidity of nerve resection, radiotherapy and chemotherapy were commenced. @entity3 is known to mimic benign pathologies. In this case there were subtle signs of a malignant process in the form of unremitting @entity2 . It is vital to keep in mind the less common @entity1 that can affect the peripheral nervous system in such cases.

title: Extraskeletal XXXX Arising from the Sciatic Nerve: A Diagnostic Challenge.

answer: @entity3


abstract: We explored the potential differences in cognitive status, lipid and @entity3 metabolism, @entity4 alleles and imaging between @entity1 and non- @entity1 subjects. 83 subjects with normal cognitive function and 114 mild @entity2 @entity0 were divided into four groups by history of @entity1 . General demographics was collected from all @entity0 followed by MRI scan, biochemical examinations and a series of neuropsychological tests. Student's t test, multiple regressions and one-way ANOVA were applied to investigate the differences between groups. Comparing @entity1 @entity0 with non- @entity1 subjects in the mild @entity2 group, we found several decreased items in recall of three words in MMSE (p=0.020), AVLT and SCWT (p<0.050). The multiple linear regression revealed that two-hour @entity3 level (B= -0.255, p<0.001) and fasting @entity6 (B= -0.466, p=0.001) had negative effects on the score of MMSE. In addition, @entity1 @entity0 treated with insulin and other @entity1 medication performed better in part of the AVLT (p<0.050) compared to @entity0 with insulin treatment or oral antidiabetic medication only. @entity0 with @entity5 medication had a better memory outcome compared to @entity0 with sulphonylurea medication in the AVLT long delay free recall (p =0.010). These findings show that @entity0 of mild @entity2 with @entity1 have a worse outcome in attention, information processing speed and memory compared to non- @entity1 @entity0 . Higher two-hour @entity3 level and @entity6 level may be risk factors for severe @entity2 in @entity1 @entity0 . The results of this study also suggest that medication may have effects on cognitive function.

title: Clinical Characteristics for the Relationship between Type-2 XXXX and @entity2 : A Cross-Sectional Study.

answer: @entity1


abstract: We explored the potential differences in cognitive status, lipid and @entity3 metabolism, @entity4 alleles and imaging between @entity1 and non- @entity1 subjects. 83 subjects with normal cognitive function and 114 mild @entity2 @entity0 were divided into four groups by history of @entity1 . General demographics was collected from all @entity0 followed by MRI scan, biochemical examinations and a series of neuropsychological tests. Student's t test, multiple regressions and one-way ANOVA were applied to investigate the differences between groups. Comparing @entity1 @entity0 with non- @entity1 subjects in the mild @entity2 group, we found several decreased items in recall of three words in MMSE (p=0.020), AVLT and SCWT (p<0.050). The multiple linear regression revealed that two-hour @entity3 level (B= -0.255, p<0.001) and fasting @entity6 (B= -0.466, p=0.001) had negative effects on the score of MMSE. In addition, @entity1 @entity0 treated with insulin and other @entity1 medication performed better in part of the AVLT (p<0.050) compared to @entity0 with insulin treatment or oral antidiabetic medication only. @entity0 with @entity5 medication had a better memory outcome compared to @entity0 with sulphonylurea medication in the AVLT long delay free recall (p =0.010). These findings show that @entity0 of mild @entity2 with @entity1 have a worse outcome in attention, information processing speed and memory compared to non- @entity1 @entity0 . Higher two-hour @entity3 level and @entity6 level may be risk factors for severe @entity2 in @entity1 @entity0 . The results of this study also suggest that medication may have effects on cognitive function.

title: Clinical Characteristics for the Relationship between Type-2 @entity1 and XXXX : A Cross-Sectional Study.

answer: @entity2


abstract: BACKGROUND AND PURPOSE:    @entity6 ( @entity6 ) exhibit a combination of signs and symptoms, mainly characterized by @entity2 and dysfunction, which impairs the functional capacity of the mastication system. These symptoms may produce a negative impact on social activities, employment and leisure. The aim of this study was to early identify the signs and symptoms of @entity6 and their impact on daily life of non- @entity0 university students.    METHODS:    Data were collected from 183 students of the dentistry course. The @entity5 II of the Research Diagnostic Criteria for @entity6 was administered and analyzed using Spearman test at a significance level of 0.05.    RESULTS:    Among the 183 @entity0 , 107 were @entity0 (58.47%) and 76 were @entity0 (41.53%). Age ranged from 18 to 47, with a mean age of 25.35 years. In relation to @entity2 intensity and disability, 129 @entity0 (70.88%) reported no @entity2 in the previous 6 months. An analysis of @entity4 revealed that 35 (19.67%) had moderate and 7 (3.83%) had severe @entity4 . The assessment of nonspecific physical symptoms including @entity2 revealed that nine (4.92%) exhibited moderate symptoms, and one (0.55%) exhibited severe symptoms. The nonspecific physical symptoms excluding items of @entity2 analysis revealed that 44 (24.04%) exhibited moderate symptoms, and 91 (49.73%) exhibited severe. The functions reported as most adversely affected by @entity1 were @entity7 , eating hard foods, chewing, smiling and laughing. Regarding the habit, 64 (35%) confirmed having the nighttime and 59 daytime (32.3%) teeth grinding with a significant correlation with the four domains analyzed. A significant correlation was observed among all domains.    CONCLUSION:    This study analyzed a young population that exhibited @entity3 and nonspecific physical symptoms excluding @entity2 that need some intervention since they could progress to a symptomatic @entity6 in future.

title: Signs and symptoms of XXXX and their impact on psychosocial status in non- @entity0 university student's population.

answer: @entity6


abstract: BACKGROUND AND PURPOSE:    @entity6 ( @entity6 ) exhibit a combination of signs and symptoms, mainly characterized by @entity2 and dysfunction, which impairs the functional capacity of the mastication system. These symptoms may produce a negative impact on social activities, employment and leisure. The aim of this study was to early identify the signs and symptoms of @entity6 and their impact on daily life of non- @entity0 university students.    METHODS:    Data were collected from 183 students of the dentistry course. The @entity5 II of the Research Diagnostic Criteria for @entity6 was administered and analyzed using Spearman test at a significance level of 0.05.    RESULTS:    Among the 183 @entity0 , 107 were @entity0 (58.47%) and 76 were @entity0 (41.53%). Age ranged from 18 to 47, with a mean age of 25.35 years. In relation to @entity2 intensity and disability, 129 @entity0 (70.88%) reported no @entity2 in the previous 6 months. An analysis of @entity4 revealed that 35 (19.67%) had moderate and 7 (3.83%) had severe @entity4 . The assessment of nonspecific physical symptoms including @entity2 revealed that nine (4.92%) exhibited moderate symptoms, and one (0.55%) exhibited severe symptoms. The nonspecific physical symptoms excluding items of @entity2 analysis revealed that 44 (24.04%) exhibited moderate symptoms, and 91 (49.73%) exhibited severe. The functions reported as most adversely affected by @entity1 were @entity7 , eating hard foods, chewing, smiling and laughing. Regarding the habit, 64 (35%) confirmed having the nighttime and 59 daytime (32.3%) teeth grinding with a significant correlation with the four domains analyzed. A significant correlation was observed among all domains.    CONCLUSION:    This study analyzed a young population that exhibited @entity3 and nonspecific physical symptoms excluding @entity2 that need some intervention since they could progress to a symptomatic @entity6 in future.

title: Signs and symptoms of @entity6 and their impact on psychosocial status in non- XXXX university student's population.

answer: @entity0


abstract: BACKGROUND: Microbial polyesters, also known as polyhydroxyalkanoates (PHAs), closely resemble physical and mechanical features of petroleum derived plastics. Recombinant @entity2 strains are being used in industrial production of PHAs in Stirred Tank Bioreactors (STRs). However, use of Air-Lift Reactors (ALRs) has been known to offer numerous technical operating options over STRs, and as such has been successfully implemented in many bioprocesses. Halomonas boliviensis is a halophilic bacterium that is known to assimilate various @entity5 and convert them into a particular type of PHA known as @entity10 ( @entity11 ). Owing to this capability, it has been used to synthesize the @entity4 using hydrolysates of starch or @entity6 bran in stirred tank bioreactors. RESULTS: This research article firstly describes the production of @entity11 in shake flasks by H. boliviensis using different combinations of @entity5 and partially hydrolyzed starch as @entity1 sources. The highest @entity11 yields, between 56 and 61  % (wt.), were achieved when either starch hydrolysate or a mixture of @entity0 and @entity7 were used as @entity1 sources. The starch hydrolysate obtained in this study was then used as @entity1 source in an ALR. The largest amount of @entity11 , 41  % (wt.), was attained after 24  hrs of cultivation during which @entity8 in the hydrolysate was assimilated more rapidly than @entity0 during active cell growth; however, the rate of assimilation of both the @entity5 was found to be similar during synthesis of @entity11 . An incomplete @entity13 pathway, which lacks @entity12 dehydrogenase, was deduced from the genome sequence of this bacterium and may result in the characteristic assimilation of @entity0 and @entity8 by the cells. CONCLUSIONS: This study showed that the production of @entity11 by H. boliviensis using cheap substrates such as starch hydrolysate in a simple production system involving an ALR is feasible. Both @entity8 and @entity0 in the hydrolysate induce cell growth and @entity11 synthesis; most likely the cells balance adequately @entity9 and @entity3 during the assimilation of these @entity5 . The combination of cheap substrates, simple production systems and the use of non-strict sterile conditions by the halophile H. boliviensis are desirable traits for large scale production of @entity11 , and should lead to a competitive bioprocess.

title: Production of XXXX by Halomonas boliviensis in an air-lift reactor.

answer: @entity10


abstract: We developed the Japanese Registry of Neuroendovascular Therapy 2 (JR-NET2) database and used the information for a retrospective, nation-wide multicenter, observational study to clarify the clinical characteristics, current status of procedures, and outcome of @entity0 treated by neuroendovascular therapy in Japan. In this report, we analyzed the clinical characteristics of @entity5 ( @entity5 ) in the JR-NET2 database. All @entity0 with @entity5 treated with endovascular therapy in 150 Japanese hospitals were included. @entity0 characteristics, clinical presentations, and imaging characteristics were analyzed. A total of 1,075 @entity0 with @entity5 underwent 1,520 endovascular procedures. Of 1,075 @entity0 , 45% were @entity0 and 55% were @entity0 . The mean age was 65  13 years. The most frequent location of @entity5 was the cavernous sinus (43.6%), followed by the @entity6 ( @entity6 ) (33.4%). Twelve percent of the @entity0 had @entity2 , 9% had @entity3 , and 3% had @entity1 . The statistically significant independent risk factors of @entity2 were @entity6 , superior sagittal sinus (SSS), tentorium, anterior cranial fossa, cranio-cervical junction, cortical @entity4 (CVR), and varix. Risk factors of @entity3 were age older than 60 years, male sex, @entity6 , SSS, and CVR. Risk factors of @entity1 were male sex, SSS, and CVR. This is the largest nationwide report, to date, of the clinical characteristics of @entity5 treated by neuroendovascular therapy. CVR was a major risk factor of aggressive symptoms.

title: Epidemiology of XXXX in Japan: Analysis of Japanese Registry of Neuroendovascular Therapy (JR-NET2).

answer: @entity5


abstract: Parent @entity2 (PAO) is an alternative to surgical clipping or endovascular endosaccular coil embolization for the management of @entity3 . Most @entity4 are not amenable to endosaccular coil embolization due to anatomical considerations, such as a broad-neck. However, majority of reports regarding the safety of PAO are based on case series involving a relatively small number of @entity0 . In the present study, a total of 381 consecutive @entity0 with unruptured @entity3 who were treated with PAO were extracted from the Japanese Registry of Neuroendovascular Therapy (JR-NET) 1 and JR-NET2 database, which are nationwide surveys conducted by the Japanese Society of Neuroendovascular Therapy. The mean age of the 381 @entity0 was 58.1 years, and 59.3% were female. The aneurysmal location included the vertebral artery (42%) and the cavernous portion of internal carotid artery (32%). The @entity4 size and shape consisted of fusiform (45%), giant (25%), and large (22%). Symptomatic lesions were present in 59.8% of the population. Technical success was achieved in 98.4%. The 30-day morbidity and mortality rates were 3.1% and 1.0%, respectively. The most frequent procedure-related complication was @entity1 , which occurred in 12.9% (distal embolism, 6.0%; branch occlusion, 3.9%). The 30-day morbidity and mortality rates related to @entity1 were 2.1% and 0.3%, respectively. PAO for @entity4 is feasible with a high technical success rate. Peri-procedural management of @entity1 is the key to enhance the safety of this treatment option.

title: Parent Artery Occlusion for Unruptured XXXX : The Japanese Registry of Neuroendovascular Therapy (JR-NET) 1 and 2.

answer: @entity3