abstract: UNASSIGNED: In a thermally driven rotary motor made from double-walled @entity0 nanotubes, the @entity2 (inner tube) can be actuated to rotate within the stator (outer tube) when the environmental temperature is high enough. A sudden stoppage of the @entity2 can occur when the inner tube has been actuated to rotate at a stable high speed. To find the mechanisms of such sudden stoppages, eight motor models with the same @entity2 but different stators are built and simulated in the canonical NVT ensembles. Numerical results demonstrate that the sudden stoppage of the @entity2 occurs when the difference between radii is near 0.34 nm at a high environmental temperature. A smaller difference between radii does not imply easier activation of the @entity1 . During rotation, the positions and electron density distribution of atoms at the ends of the motor show that a sp(1) bonded atom on the @entity2 is attracted by the sp(1) atom with the biggest deviation of radial position on the stator, after which they become two sp(2) atoms. The strong bond interaction between the two atoms leads to the loss of rotational speed of the @entity2 within 1 ps. Hence, the sudden stoppage is attributed to two factors: the deviation of radial position of atoms at the stator's ends and the drastic thermal vibration of atoms on the @entity2 in rotation. For a stable motor, sudden stoppage could be avoided by reducing deviation of the radial position of atoms at the stator's ends. A nanobrake can be, thus, achieved by adjusting a sp(1) atom at the ends of stator to stop the rotation of @entity2 quickly.

title: XXXX in a thermally driven rotary motor made from double-walled @entity0 nanotubes.

answer: @entity1


abstract: UNASSIGNED: The liver is the most central organ and the largest gland of the body that influences and controls a variety of metabolic and catabolic processes. It produces inconceivable many essential proteins, is responsible for the recovery of various food components, degrades toxins, mediates the bile production, and is involved in the excretion of unwanted metabolites. Several of these anabolic or catabolic functions of the liver depend on trace elements. These are either integral part of enzymes, cofactors, or act as chemical catalysts. Therefore, a lack of trace elements can lead to organ failure or @entity4 . Conversely, excessive hepatic trace element deposition resulting from @entity0 , intoxication, extensive dietary supply, or long-term parenteral nutrition may cause @entity2 , @entity1 , @entity1 , and even @entity3 . Although specific serum parameters currently allow rough assessment of metal deficit and excess, the precise quantification of hepatic metal content in liver is presently only possible by different titration or staining techniques of biopsy specimens. Recently, novel innovative metal imaging techniques were developed that are on the way to replace these traditional methods. In the present review, we summarize the function of different trace elements in liver health and disease and discuss the present knowledge on how quantitative biometal imaging techniques such as synchrotron X-ray fluorescence microscopy, secondary ion mass spectrometry, and laser ablation inductively coupled plasma mass spectrometry enrich diagnostics in the detection and quantification of @entity2 . We will further discuss sample preparation, sensitivity, spatial resolution, specificity, quantification strategies, and potential future applications of metal bioimaging in experimental research and clinical daily routine.    2015 Wiley Periodicals, Inc. Mass Spec Rev 35:666-686, 2016.

title: Trace metal imaging in diagnostic of XXXX .

answer: @entity2


abstract: BACKGROUND: T cells and macrophages are implicated in the pathogenesis of @entity1 ( @entity1 ) and @entity3 . We recently demonstrated that a vaccine using an @entity9 -related peptide @entity11 reduces @entity3 with favorable modulation of CD8(+) T cells in @entity8 -deficient (apoE(-/-)) @entity0 . OBJECTIVES: This study hypothesized that a @entity11 vaccine could reduce @entity1 formation in the @entity10 ( @entity10 )-induced @entity1 model. METHODS: Male apoE(-/-) @entity0 were immunized with @entity11 vaccine and implanted with an @entity10 -releasing pump for 4  weeks. Flow cytometry assessed T cell activation and phenotype. @entity4 ( @entity4 ) and @entity5 ( @entity5 ) expression were assessed using reverse transcription polymerase chain reaction. We used ex  vivo aortic explants to test monocyte adhesion and in  vitro cocultures to evaluate CD8(+) T cell function. RESULTS: The @entity11 vaccine activated CD8(+) T cells and reduced @entity1 formation and mortality due to @entity6 , which was attenuated by CD8(+) T cell depletion. Vaccination decreased expression of @entity4 and @entity5  and reduced macrophage infiltration in the aorta. Cytotoxic T-lymphocyte assay showed that CD8(+) T cells from @entity11 -immunized @entity0 had higher lytic activity against @entity10 -stimulated macrophages. The @entity11 vaccine decreased splenic Th17 cells, and in  vitro coculture of @entity7 (+) and CD8(+) T cells showed that CD8(+) T cells from @entity11 -immunized @entity0 inhibited the polarization of @entity7 (+) T cells into Th17 cells. @entity2 (-/-) @entity0 infused with a higher dose of @entity10 did not develop @entity6 . CONCLUSIONS: A @entity11 vaccine protected against @entity10 -induced @entity1 formation and mortality by reducing macrophage infiltration in the aorta and decreasing Th17 cell polarization. Our findings provide a potentially novel immunomodulating approach against @entity1 .

title: XXXX -Related Peptide Vaccine Protects Against @entity10 -Induced @entity1 Formation and Rupture.

answer: @entity9


abstract: BACKGROUND: T cells and macrophages are implicated in the pathogenesis of @entity1 ( @entity1 ) and @entity3 . We recently demonstrated that a vaccine using an @entity9 -related peptide @entity11 reduces @entity3 with favorable modulation of CD8(+) T cells in @entity8 -deficient (apoE(-/-)) @entity0 . OBJECTIVES: This study hypothesized that a @entity11 vaccine could reduce @entity1 formation in the @entity10 ( @entity10 )-induced @entity1 model. METHODS: Male apoE(-/-) @entity0 were immunized with @entity11 vaccine and implanted with an @entity10 -releasing pump for 4  weeks. Flow cytometry assessed T cell activation and phenotype. @entity4 ( @entity4 ) and @entity5 ( @entity5 ) expression were assessed using reverse transcription polymerase chain reaction. We used ex  vivo aortic explants to test monocyte adhesion and in  vitro cocultures to evaluate CD8(+) T cell function. RESULTS: The @entity11 vaccine activated CD8(+) T cells and reduced @entity1 formation and mortality due to @entity6 , which was attenuated by CD8(+) T cell depletion. Vaccination decreased expression of @entity4 and @entity5  and reduced macrophage infiltration in the aorta. Cytotoxic T-lymphocyte assay showed that CD8(+) T cells from @entity11 -immunized @entity0 had higher lytic activity against @entity10 -stimulated macrophages. The @entity11 vaccine decreased splenic Th17 cells, and in  vitro coculture of @entity7 (+) and CD8(+) T cells showed that CD8(+) T cells from @entity11 -immunized @entity0 inhibited the polarization of @entity7 (+) T cells into Th17 cells. @entity2 (-/-) @entity0 infused with a higher dose of @entity10 did not develop @entity6 . CONCLUSIONS: A @entity11 vaccine protected against @entity10 -induced @entity1 formation and mortality by reducing macrophage infiltration in the aorta and decreasing Th17 cell polarization. Our findings provide a potentially novel immunomodulating approach against @entity1 .

title: @entity9 -Related Peptide Vaccine Protects Against @entity10 -Induced XXXX Formation and Rupture.

answer: @entity1


abstract: BACKGROUND: T cells and macrophages are implicated in the pathogenesis of @entity1 ( @entity1 ) and @entity3 . We recently demonstrated that a vaccine using an @entity9 -related peptide @entity11 reduces @entity3 with favorable modulation of CD8(+) T cells in @entity8 -deficient (apoE(-/-)) @entity0 . OBJECTIVES: This study hypothesized that a @entity11 vaccine could reduce @entity1 formation in the @entity10 ( @entity10 )-induced @entity1 model. METHODS: Male apoE(-/-) @entity0 were immunized with @entity11 vaccine and implanted with an @entity10 -releasing pump for 4  weeks. Flow cytometry assessed T cell activation and phenotype. @entity4 ( @entity4 ) and @entity5 ( @entity5 ) expression were assessed using reverse transcription polymerase chain reaction. We used ex  vivo aortic explants to test monocyte adhesion and in  vitro cocultures to evaluate CD8(+) T cell function. RESULTS: The @entity11 vaccine activated CD8(+) T cells and reduced @entity1 formation and mortality due to @entity6 , which was attenuated by CD8(+) T cell depletion. Vaccination decreased expression of @entity4 and @entity5  and reduced macrophage infiltration in the aorta. Cytotoxic T-lymphocyte assay showed that CD8(+) T cells from @entity11 -immunized @entity0 had higher lytic activity against @entity10 -stimulated macrophages. The @entity11 vaccine decreased splenic Th17 cells, and in  vitro coculture of @entity7 (+) and CD8(+) T cells showed that CD8(+) T cells from @entity11 -immunized @entity0 inhibited the polarization of @entity7 (+) T cells into Th17 cells. @entity2 (-/-) @entity0 infused with a higher dose of @entity10 did not develop @entity6 . CONCLUSIONS: A @entity11 vaccine protected against @entity10 -induced @entity1 formation and mortality by reducing macrophage infiltration in the aorta and decreasing Th17 cell polarization. Our findings provide a potentially novel immunomodulating approach against @entity1 .

title: @entity9 -Related Peptide Vaccine Protects Against XXXX -Induced @entity1 Formation and Rupture.

answer: @entity10


abstract: PURPOSE: This study sought to compare the association between health-related quality of life (HRQoL) and four body health types by gender. METHODS: The study included 6217 @entity0 and 8243 @entity0 over 30  years of age chosen from a population-based survey. @entity0 were grouped by body mass index and @entity3 into four types: metabolically healthy normal weight, metabolically abnormal but normal weight (MANW), @entity1 ( @entity1 ), and @entity3 ( @entity3 ). HRQoL was measured using the EQ-5D health questionnaire. The outcomes encompassed five dimensions (mobility, self-care, usual activity, @entity2 /discomfort, and @entity4 ), and the impaired HRQoL dichotomized by the EQ-5D preference score. Complex sample multivariate binary logistic regression analyses were conducted to adjust for sociodemographic variables, lifestyle factors, and disease comorbidity. RESULTS: Among @entity0 , those in the MANW group presented worse conditions on all dimensions and the impaired HRQoL compared to other @entity0 . However, no significant effect remained after adjusting for relevant covariates. For @entity0 , those in the @entity3 group had the most adversely affected HRQoL followed by those females in the @entity1 group. The domain of mobility and @entity3 and @entity1 groups remained significant when controlling for all covariates in the model. CONCLUSIONS: The MANW is the least favorable condition of HRQoL for @entity0 , suggesting that metabolic health may associate with HRQoL more than @entity1 for males. In @entity0 , the @entity3 and @entity1 groups had the most adversely affected HRQoL, implying that @entity1 is not a favorable health condition and that @entity1 , in general, may be strongly associated with HRQoL in @entity0 .

title: Obesity, XXXX , and health-related quality of life by gender: a cross-sectional study in Korean adults.

answer: @entity3


abstract: 1. @entity0 were prepared for chronic recordings from the lumbar enlargement of the spinal dorsal horn. At the beginning of each recording session, a @entity2 microelectrode was advanced through the dura in a physiologically intact, awake, drug-free animal, until amplitude discrimination provided a single neuron with a receptive field on the hindquarters. 2. Extracellular recordings of activity of each neuron were made during receptive field stimulation with tactile and thermal nonnoxious and noxious stimuli. 3. Baseline responses obtained in the awake state were compared with responses of the same neurons during slow-wave or rapid-eye-movement (REM) sleep. In a subpopulation of neurons, the effects of anesthesia ( @entity1 , 7.5 mg/kg iv) were observed after the completion of sleep studies. 4. The low-threshold receptive fields of the seven neurons studied during REM sleep were all increased in size when compared with the baseline value. The average increase was 52.6% (range 26.2-96.7%). 5. The low-threshold receptive fields of the seven neurons studied during REM sleep were reduced by @entity1 anesthesia by an average of 49.1% (range 29-74%). 6. Neuronal response to receptive field brushing was observed in 15 neurons during REM sleep. The effect of @entity1 on receptive field brushing was observed in 8 of those neurons. In only one of those eight neurons were the effects of REM sleep and anesthesia in the same direction. 7. Changes in neuronal responses were less consistent during slow-wave sleep but still differed from changes induced by @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Low-threshold neuronal activity of spinal dorsal horn neurons increases during REM sleep in XXXX : comparison with effects of anesthesia.

answer: @entity0


abstract: We constructed an accurate polyether force field for implicit solvent (IS) @entity0 ( @entity0 ) simulations that matches local and global conformations of @entity5 ( @entity6 ) and @entity2 ( @entity3 ), respectively. To make appropriate force field adjustments for IS models of @entity3 , we used long-term @entity0 simulation data of 1  s in explicit solvent (ES) based on the most recent CHARMM35 ether force field that includes adjustments for @entity3 in explicit water. In IS models, competition of attractive @entity1 Waals (vdW) interactions between solute-solute and solute-solvent atom pairs is often not considered explicitly. As a consequence, the attractive vdW interactions between solute atom pairs that remain in IS models explicitly can yield equilibrium structures that are too compact. This behavior was observed in the present study comparing @entity0 simulation data of the @entity6 and @entity3 ES model with corresponding IS models that use generalized Born (GB) electrostatics combined with positive surface energy terms favoring compact structures. To regain balance of attractive vdW interactions for IS models, we considered the IS generalized Born with simple switching (GBSW) model in detail, where we turned off surface energy terms and reduced attractive vdW interactions to 90%, or we used alternatively even slightly negative surface energies. However, to obtain quantitatively the same local and global distributions of @entity3 conformers as in ES, we needed additional force field adjustments involving torsion potentials and 1-4 and 1-5 atom pair Coulomb interactions. This CHARMM ether force field, specifically optimized for IS simulation conditions, is equally valid for dimeric and polymeric @entity4 . To explore the conformational space of @entity3 with @entity0 simulations, an IS GBSW model requires 2 orders of magnitude less CPU time than the corresponding ES model. About a factor of 5 of this gain in efficiency is due to the lack of solvent viscosity in IS models.

title: Merging Implicit with Explicit Solvent Simulations: XXXX .

answer: @entity2


abstract: Seventeen @entity1 GABAA receptor subtypes were transiently expressed in the @entity0 embryonic kidney 293 cell line from alpha 1, alpha 2, alpha 3, alpha 5, or alpha 6 variants with any of the three beta subunits and gamma 2S or gamma 3. We obtained fingerprints in the form of subtype characteristic concentration-response curves of 35S-TBPS binding to @entity3 and the GABAA antagonists @entity4 and @entity2 . alpha 3 beta 3 gamma 2S/3 and alpha 5 beta 3 gamma 2S/3 containing receptors effectively recognized 35S-TBPS but not when beta 3 was replaced by the @entity6 subunit. This indicates a specific interaction of alpha and beta variants to form high-affinity 35S-TBPS binding sites. At low levels @entity3 allosterically increased 35S-TBPS binding to all receptors with the concentration and magnitude depending on the subunit combination. Exchange of the beta variant did not alter the concentration-response curves for alpha 1 and alpha 6 containing receptors but did so for alpha 2 containing receptors. alpha 2 beta 3 gamma 3 receptors displayed strong @entity3 -induced stimulation of 35S-TBPS binding, whereas binding to alpha 2 beta 3 gamma 3 receptors was marginally increased. @entity4 and @entity2 decreased 35S-TBPS binding to all gamma 3 containing receptors. In addition, @entity2 was effective on alpha 1 beta x gamma 2 receptors. @entity4 was threefold more potent than @entity2 in reversing @entity3 -induced modulation of 35S-TBPS binding in most receptor types, but was 30-fold more potent on alpha 2 @entity5 gamma 3 and alpha 6 @entity5 gamma 2S receptors.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX antagonists differentiate between recombinant GABAA/benzodiazepine receptor subtypes.

answer: @entity3


abstract: The aim of this study was to evaluate whether segments with reverse redistribution on rest-redistribution 201Tl scintigraphy represent viable tissue or scar. METHODS: Nineteen @entity0 (17 @entity0 , 2 @entity0 ; mean age 53 +/- 8 yr) with @entity1 underwent rest-redistribution 201Tl study before coronary revascularization. Regional 201Tl uptake was analyzed quantitatively. Regional left ventricular wall motion was assessed before and after coronary revascularization using two-dimensional echocardiography and a three-point scale (1 = normal, 2 = @entity5 , 3 = @entity4 / @entity2 ). Two patterns of reverse redistribution were identified: pattern with normal 201Tl uptake in rest and abnormal in redistribution images and pattern with abnormal 201Tl uptake in rest and a significant decrease in redistribution images. RESULTS: Of the 247 segments analyzed, 85 were classified as normal, 37 as reversible defects, 83 as fixed defects and 42 as reverse redistribution (19 RR-A, 23 RR-B). Segments with RR-A differed from those with RR-B in wall motion score (1.4 +/- 0.7 versus 2.0 +/- 1.0). Electrocardiographic Q-waves were present in 26% of segments with RR-A and in 57% of segments with pattern B. After revascularization, all @entity3 with pattern A showed improved wall motion, while only 40% of segments with pattern B and abnormal wall motion had such improvement. CONCLUSION: Our results suggest that @entity3 with pattern A should be considered viable, while more caution should be used in classifying those with pattern B.

title: Reverse redistribution in resting thallium-201 myocardial scintigraphy in chronic XXXX : an index of myocardial viability.

answer: @entity1


abstract: AIM: The purpose of this study was to explore the PECN students' clinical decision-making during a seven-week clinical rotation in the ambulance services. INTRODUCTION: Developing expertise in @entity1 care practices requires both theoretical and empirical learning. A @entity1 care nurse (PECN) is a Registered Nurse (RN) with one year of additional training in emergency care. There has been little investigation of how PECN students describe their decision-making during a clinical rotation. METHODS: A qualitative study design was used, and 12 logbooks written by the Swedish PECN students were analysed using content analysis. FINDINGS: The students wrote about 997 @entity0 encounters - ambulance assignments during their clinical rotation. Four themes emerged as crucial for the students' decision-making: knowing the @entity0 , the context-situation awareness in the ambulance service, collaboration, and evaluation. Based on the themes, students made decisions on how to respond to @entity0 ' illnesses. CONCLUSION: The PECN students used several variables in their decision-making. The decision- making was an on-going process during the whole ambulance assignment. The university has the responsibility to guide the students during their transition from an RN to a PECN. The findings of the study can support the educators and clinical supervisors in developing the programme of study for becoming a PECN.

title: Clinical decision-making described by Swedish XXXX care nurse students - An exploratory study.

answer: @entity1


abstract: OBJECTIVE: This study examines characteristics of individuals with @entity2 who sought psychotherapy versus those who did not. METHODS: Bipolar CHOICE was an 11-site comparative effectiveness study of @entity4 versus @entity3 in symptomatic outpatients (N = 482) with @entity2 . At baseline, @entity0 ' psychotherapy use within the past 3 months, mood, functioning, and overall health were assessed. Logistic regressions were used to test whether psychotherapy users and non-users differed on various demographic and clinical variables at baseline. Mixed-effects regression was used to determine whether psychotherapy groups differed on response to treatment over the 6-month study. Kaplan-Meier plots and log-rank tests were employed to test whether there were any differences in time to recovery (CGI-BP  <= 2 for at least 8 weeks) between the groups. RESULTS: Thirty one percent of @entity0 reported using psychotherapy services. Psychotherapy users reported greater medication side effect burden than non-users and were more likely to have moderate to high suicide risk and at least one @entity1 . @entity0 not utilizing medications or psychotherapy had greater mania symptom severity, were younger, and less educated than medication only users. Medication only users were more likely to be married than the other @entity0 . CONCLUSIONS: These data suggest that a minority of individuals with @entity2 attend psychotherapy services, and those that do have greater illness burden.

title: Psychotherapy use in XXXX : Association with functioning and illness severity.

answer: @entity2


abstract: Drug-induced @entity9 is a tissue-specific condition and is estimated to affect approximately one million North Americans. Lesions occur principally as side-effects from @entity8 , @entity6 , or @entity4 therapy in approximately half of the @entity0 who take these agents. Due to new indications for these drugs, their use continues to grow. Here, we review the molecular and cellular characteristics of @entity0 @entity9 and highlight how they differ considerably as a function of the causative drug. Analyses of molecular signaling pathways in cultured @entity0 gingival fibroblasts have provided evidence for their unique aspects compared with fibroblasts from the lung and kidney. These findings provide insights into both the basis for tissue specificity and into possible therapeutic opportunities which are reviewed here. Although @entity4 -induced @entity9 exhibit principally the presence of @entity2 and little @entity3 , @entity6 - and especially @entity8 -induced lesions are highly fibrotic. The increased expression of markers of gingival @entity3 , particularly @entity10 [also known as @entity10 ( @entity10 )], markers of epithelial to mesenchymal transition, and more recently periostin and members of the @entity12 oxidase family of enzymes have been documented in @entity8 or @entity6 lesions. Some oral @entity5 such as @entity11 and @entity7 , after subsequent additional genetic damage, can develop into @entity1 . Since many pathways are shared, the study of gingival @entity3 and comparisons with characteristics and molecular drivers of @entity1 would likely enhance understandings and functional roles of molecular drivers of these oral pathologies.

title: Molecular and clinical aspects of drug-induced XXXX .

answer: @entity9


abstract: BACKGROUND: This study investigated blackberry (Persian mulberry) effects on apo A-I, @entity4 , high-sensitivity-C-reactive protein (hs-CRP), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in dyslipidemic @entity0 . MATERIALS AND METHODS: In this 8-week randomized clinical trial, 72 dyslipidemic @entity0 were randomly divided into two groups: Intervention (300 mL/day blackberry juice with pulp) and control group (usual diets). Before and after the intervention, fasting blood samples were taken from both groups and serum concentration of lipoprotein, @entity5 , serum lipids (total @entity1 , low-density lipoprotein, high-density lipoprotein [HDL], and @entity3 ), hs-CRP were measured. Blood pressure before and after the study was measured with a @entity2 manometer. RESULTS: At week 8 in the intervention group, apo A-I and HDL increased significantly (P = 0.015, P = 0.001, respectively), @entity4 and hs-CRP decreased significantly (P = 0.044, P = 0.04, respectively). Mean changes in @entity5 /apo A-I ratio were significant between the groups (P = 0.005, P = 0.014, and P = 0.009, respectively). After 8 weeks, there was a significant difference between hs-CRP mean values (P = 0.01) of the groups. At week 8, SBP decreased significantly (P = 0.005) in the intervention group with no significant differences for SBP mean values between the groups. No significant changes were observed in other lipid parameters and DBP in the intervention group and between the groups. CONCLUSION: Blackberry consumption may exert beneficial effects on apolipoproteins, blood pressure, and inflammatory markers in individuals with @entity6 .

title: Effects of blackberry (Morus nigra L.) consumption on serum concentration of lipoproteins, apo A-I, XXXX , and high-sensitivity-C-reactive protein and blood pressure in dyslipidemic @entity0 .

answer: @entity4


abstract: BACKGROUND: This study investigated blackberry (Persian mulberry) effects on apo A-I, @entity4 , high-sensitivity-C-reactive protein (hs-CRP), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in dyslipidemic @entity0 . MATERIALS AND METHODS: In this 8-week randomized clinical trial, 72 dyslipidemic @entity0 were randomly divided into two groups: Intervention (300 mL/day blackberry juice with pulp) and control group (usual diets). Before and after the intervention, fasting blood samples were taken from both groups and serum concentration of lipoprotein, @entity5 , serum lipids (total @entity1 , low-density lipoprotein, high-density lipoprotein [HDL], and @entity3 ), hs-CRP were measured. Blood pressure before and after the study was measured with a @entity2 manometer. RESULTS: At week 8 in the intervention group, apo A-I and HDL increased significantly (P = 0.015, P = 0.001, respectively), @entity4 and hs-CRP decreased significantly (P = 0.044, P = 0.04, respectively). Mean changes in @entity5 /apo A-I ratio were significant between the groups (P = 0.005, P = 0.014, and P = 0.009, respectively). After 8 weeks, there was a significant difference between hs-CRP mean values (P = 0.01) of the groups. At week 8, SBP decreased significantly (P = 0.005) in the intervention group with no significant differences for SBP mean values between the groups. No significant changes were observed in other lipid parameters and DBP in the intervention group and between the groups. CONCLUSION: Blackberry consumption may exert beneficial effects on apolipoproteins, blood pressure, and inflammatory markers in individuals with @entity6 .

title: Effects of blackberry (Morus nigra L.) consumption on serum concentration of lipoproteins, apo A-I, @entity4 , and high-sensitivity-C-reactive protein and blood pressure in dyslipidemic XXXX .

answer: @entity0


abstract: UNASSIGNED: The use of ischemic preconditioning (IPC) to protect the myocardium is usually not effective in elderly @entity0 . The aim of the present study was to design new methods to achieve enhanced myocardial protection, based on the differential role of endogenous @entity3 ( @entity4 ) and @entity4 receptors (ARs) in the effects of IPC on young and old animals. An improved New Zealand white @entity2 model of @entity1 /reperfusion was established based on the Langendorff model. Adult or elderly @entity2 hearts, with or without exposure to IPC, were used in order to assess the roles of @entity4 and ARs in the different effects of IPC. Different protective methods were designed based on a combination of endogenous and exogenous interventions. Cardiac function, as well as biochemical, histopathological and apoptotic indices, were measured in the different intervention groups. The improved Langendorff model was stable, reliable and suitable for the undertaking of the experiments. The @entity4 levels in the aged @entity2 hearts pre- and post-IPC were lower than those in the adult hearts, indicating that @entity4 levels may be an endogenous factor influencing IPC. A new protection strategy combining @entity4 -enhanced IPC, A1AR agonist @entity5 preconditioning and cold crystalloid cardioplegia had a significant protective effect in aged hearts. The results of the present study suggested that endogenous @entity4 enhancement, A1AR agonist preconditioning and exogenous treatment yield an additive effect in aged @entity2 hearts. The simultaneous application of these three types of intervention provided the most effective myocardial protection in the improved aged @entity2 heart model.

title: Novel cardioprotective strategy combining three different preconditioning methods to prevent @entity1 /reperfusion injury in aged hearts in an improved XXXX model.

answer: @entity2


abstract: UNASSIGNED: The use of ischemic preconditioning (IPC) to protect the myocardium is usually not effective in elderly @entity0 . The aim of the present study was to design new methods to achieve enhanced myocardial protection, based on the differential role of endogenous @entity3 ( @entity4 ) and @entity4 receptors (ARs) in the effects of IPC on young and old animals. An improved New Zealand white @entity2 model of @entity1 /reperfusion was established based on the Langendorff model. Adult or elderly @entity2 hearts, with or without exposure to IPC, were used in order to assess the roles of @entity4 and ARs in the different effects of IPC. Different protective methods were designed based on a combination of endogenous and exogenous interventions. Cardiac function, as well as biochemical, histopathological and apoptotic indices, were measured in the different intervention groups. The improved Langendorff model was stable, reliable and suitable for the undertaking of the experiments. The @entity4 levels in the aged @entity2 hearts pre- and post-IPC were lower than those in the adult hearts, indicating that @entity4 levels may be an endogenous factor influencing IPC. A new protection strategy combining @entity4 -enhanced IPC, A1AR agonist @entity5 preconditioning and cold crystalloid cardioplegia had a significant protective effect in aged hearts. The results of the present study suggested that endogenous @entity4 enhancement, A1AR agonist preconditioning and exogenous treatment yield an additive effect in aged @entity2 hearts. The simultaneous application of these three types of intervention provided the most effective myocardial protection in the improved aged @entity2 heart model.

title: Novel cardioprotective strategy combining three different preconditioning methods to prevent XXXX /reperfusion injury in aged hearts in an improved @entity2 model.

answer: @entity1


abstract: We present the case of a 40-year-old @entity0 with rapidly deteriorating acute @entity9 , finally diagnosed as eastern equine @entity3 (EEE). The course and timing in this @entity0 are quite characteristic. EEE is an arthropod @entity5 in which the mosquito serves as the vector. It is amongst the most severe of the @entity8 and has a high mortality and morbidity. In nonfatal cases, residual @entity2 are often severe and permanent. North American lineage of EEE is mainly found in the northeast especially along the coastal areas. EEE is primarily found in @entity6 and other domestic mammals that remain outdoors nocturnally. In @entity0 , symptoms range from nonspecific constitutional features to catastrophic @entity1 including @entity4 . @entity7 and increased cerebrospinal fluid (CSF) white blood cell count are independent predictors of poor outcomes. Diagnosis is suggestive by demonstrating IgM antibody in blood or CSF samples and can be confirmed by other serologic assay including immunohistochemistry and polymerase chain reaction (PCR). Measures recommended by the Center for Disease Control (CDC) for prevention include using repellents, protective clothing, screens, and eradication of mosquito breeding areas. EEE remains without cure and prevention is the best medicine.

title: Eastern equine XXXX : a classical case.

answer: @entity3


abstract: The main hemodynamic disturbance occurring in @entity0 with essential @entity2 is an increase in the total peripheral resistance. In young @entity0 with @entity2 , this disturbance is clearly seen during muscular exercise, even though the calculated resistance might be normal during rest. This article reports results of studies on the long-term hemodynamic effects of two @entity3 channel blockers, @entity6 and @entity5 , in @entity0 with mild to moderate @entity2 . Twenty-five @entity0 , aged 20 to 64 years, with diastolic blood pressures between 100 and 120 mm Hg before treatment were studied at rest and during exercise on ergometer bicycles. Blood pressure was recorded intra-arterially, and cardiac output was measured. After this initial study, 10 @entity0 were treated with @entity6 (from 40 to 80 mg, three times daily) and 15 @entity0 with @entity5 (long-acting form, from 40 to 80 mg daily). After one year, the hemodynamic study was repeated. Both drugs induced a @entity4 and in the total peripheral resistance without any reduction in the cardiac index. @entity6 reduced heart rate, particularly during exercise, but this effect was compensated by an increase in the @entity1 volume. The hemodynamic profile of these two @entity3 channel blockers clearly differs from the hemodynamic effects of beta blockers.

title: Hemodynamic effects of @entity3 channel blockers at rest and during exercise in essential XXXX .

answer: @entity2


abstract: The main hemodynamic disturbance occurring in @entity0 with essential @entity2 is an increase in the total peripheral resistance. In young @entity0 with @entity2 , this disturbance is clearly seen during muscular exercise, even though the calculated resistance might be normal during rest. This article reports results of studies on the long-term hemodynamic effects of two @entity3 channel blockers, @entity6 and @entity5 , in @entity0 with mild to moderate @entity2 . Twenty-five @entity0 , aged 20 to 64 years, with diastolic blood pressures between 100 and 120 mm Hg before treatment were studied at rest and during exercise on ergometer bicycles. Blood pressure was recorded intra-arterially, and cardiac output was measured. After this initial study, 10 @entity0 were treated with @entity6 (from 40 to 80 mg, three times daily) and 15 @entity0 with @entity5 (long-acting form, from 40 to 80 mg daily). After one year, the hemodynamic study was repeated. Both drugs induced a @entity4 and in the total peripheral resistance without any reduction in the cardiac index. @entity6 reduced heart rate, particularly during exercise, but this effect was compensated by an increase in the @entity1 volume. The hemodynamic profile of these two @entity3 channel blockers clearly differs from the hemodynamic effects of beta blockers.

title: Hemodynamic effects of XXXX channel blockers at rest and during exercise in essential @entity2 .

answer: @entity3


abstract: OBJECTIVE: Predictors of treatment outcome of @entity2 ( @entity2 ) in @entity0 with @entity1 ( @entity1 ) are not known. There is a pressing need for simple, clinically useful tools to predict treatment outcome. This study aimed to identify predictors of successful OA therapy for @entity1 , including evaluation of pharyngeal morphology, which can be measured during routine examination by an otorhinolaryngologist. METHODOLOGY: This was a prospective study of 26 @entity1 @entity0 treated with @entity2 . A favourable outcome was obtained in 14 @entity0 (responders) but not in 12 @entity0 (nonresponders). The baseline @entity0 characteristics and polysomnography and rhinopharyngeal findings were analysed. RESULTS: Body mass index (BMI) was significantly lower in responders versus nonresponders (23.6    2.8 vs. 27.9    4.7 kg/m2; p < 0.05). Pharyngeal morphology, age, sex and nasal resistance did not differ between the groups. Multiple regression analysis showed that BMI was a significant predictor of improvement in the apnoea/hypopnoea index after OA treatment (p < 0.05). CONCLUSION: Here we demonstrated that BMI is a favourable predictor of OA treatment outcome in @entity1 @entity0 . Among the @entity1 @entity0 , responders had wider retroglossal spaces than nonresponders.

title: Prediction of oral appliance treatment outcome in XXXX : a preliminary study.

answer: @entity1


abstract: INTRODUCTION: @entity2 is a benign lesion presenting as an enlarging abdominal mass in @entity0 less than 2 years of age. Fewer than 5% cases are present in individuals over 5 years of age, and this lesion is extremely rare in adults. It may affect the @entity2 as a cystic or solid mass or both components may be present. The pathogenesis remains incompletely understood, but these lesions have generally been considered to represent a development abnormality in the bile duct plate formation. CASE REPORT: In this report, we present a case of a 44-year-old @entity0 who was surgically treated at the Department of Abdominal, Endocrine and Transplantation Surgery of the Clinical Center of Vojvodina due to @entity4 in the liver segment IV that had been verified by computed tomography imaging diagnostics. The @entity0 was sent from a smaller health center with the diagnosis of @entity5 . After the adequate preparation of the @entity0 , surgical excision ofthe @entity2 was done. Once a thorough histological examination had been performed, the diagnosis of @entity3 was made. CONCLUSION: @entity2 is a @entity1 resulting from abnormal, intra-uterine development of bile ducts and has a delayed clinical manifestation, thus this lesion appears to be related to the processes of maturation. It is potentially pre-malignant lesion presenting as a solid and/or @entity1 . Symptoms, laboratory results and radiographic imaging are nonspecific and inconclusive, so surgical excision of the whole lesion is the imperative for the definitive diagnosis.

title: XXXX in adults--case report.

answer: @entity2


abstract: Ten @entity0 with @entity3 underwent radiation therapy of the retrobulbar orbital tissue. Between the 2nd and the 13th week preceding radiotherapy, exacerbation of the clinical symptoms had appeared in all the @entity0 , and distinct symptoms of infiltrative tissular processes were seen beside bulbar protrusion. Of the cases, 5 suffered from marked @entity1 , 6 from @entity2 , and one @entity0 had lost his visual faculty. Index numbers for the degree of the orbitopathy (4-11, average 6.7) were established in all cases, and a total focal dose amounting to maximally 1000 cGy for each retrobulbar target volume was administered in one series. The pituitary gland was not included in the radiation field. Indices for the degree of @entity4 were reduced by at least 3 points (average 3.7). Swelling of soft tissue and bulbar protrusion were decreased primarily. No improvement of @entity1 was obtained but aggravation also did not occur. Recurrences appeared in 4 @entity0 , at the earliest 4 months, at the latest 24 months after the end of the therapy. The present findings have shown orbital irradiation as an effective method for the treatment of @entity3 .

title: [Radiation therapy of XXXX . 1st communication: clinical results (author's transl)].

answer: @entity3


abstract: INTRODUCTION: Individuals with @entity2 consistently @entity1 in social cognition (SC). SC has become a potential treatment target due to its association with functional outcomes. An alternative method of assessment is to administer an observer-based scale incorporating an informant's "first hand" impressions in ratings. METHODS: The present study used the Observable Social Cognition: A Rating Scale ( @entity3 ) in 62 outpatients and 50 non-psychiatric controls (NPCs) to assess performance in domains of SC (e.g. emotion perception, theory of mind). RESULTS: The @entity3 demonstrated sufficient internal consistency and test-retest reliability. Construct validity was assessed through an exploratory factor analysis. @entity0 @entity3 indices were not significantly correlated with measures of SC with the exception of aggressive attributional style. Individuals with @entity1 in SC reacted more aggressively to ambiguous situations. NPC @entity3 were significantly correlated with measures of theory of mind and attributional style. In a combined sample of @entity0 and controls, six of eight items were significantly correlated with the SC task assessing the same domain, providing modest evidence of convergent validity. In @entity0 , the @entity3 was significantly correlated with measures of functional outcome and neurocognition. Last, the @entity3 was found to be significantly associated with functional outcome after the influence of objective measures of SC was statistically removed. CONCLUSIONS: The present study provides preliminary evidence that the @entity3 may be useful for clinicians in collecting data about @entity0 ' potential real-world @entity1 , in turn increasing the degree to which these impairments may be targeted in treatment.

title: Observable Social Cognition--A Rating Scale: an interview-based assessment for XXXX .

answer: @entity2


abstract: The authors undertook a study of changes in bone conduction (BC) during 800 operations carried out over a 5 years period (1979-1984) for @entity1 or sequelae of @entity1 . After elimination of ears with @entity2 (47) and cases unsuitable for evaluation (39), they finally included 714 records in the study. Only comparison of free and post-operative BC was made and using 4 conversational frequencies, not taking into account a deviation of 5 DB for each of these 4 frequencies. The study involved 317 myringoplasties: In 271 (i.e. 85,5%) there was no change in BC. Amongst them, 37 @entity0 nevertheless showed a transient fall in BC. Of particular importance is the fact that almost 1/3 (11 to be exact) recovered only during the 2nd semester following surgery, a period which was even exceeded in the other 5 cases. 46 (i.e. 14.5%) were classified as "permanent" falls in BC. Amongst these in only 17 (i.e. 5%) were there "only" the three standard aggression factors for the I.O.: aspiration--scraping--manipulation of the tympano-ossicular system, without it being possible to attribute a predominant role to one more than the other. With regard to reaming of the E.A.M., those cases in which this could be considered responsible appeared to be infinitesimal. Furthermore, there was no statistically significant difference (reduced deviation test--"chi"2 test) between the number of falls in BC seen following myringoplasty with or without reaming. 83 tympanoplasties by Piston-Malleus, study of which led to the same conclusions as for myringoplasties. 118 masto-atticotomies, including 23 with posterior tympanotomy. Despite peri-labyrinthine and peri-ossicular scraping, results were essentially identical. 196 evacuation cavities (227-31 @entity2 ) of which somewhat less than half only (46%) were ears undergoing surgery for the first time. Percentage of unchanged BC was here much more unfavourable, with 49 "permanent" falls in BC, i.e. 25%, of which, it must be said, 5 were minimal falls, and with, in 25 cases, a follow-up of less than 3 months.

title: [Changes in bone conduction in the surgery of XXXX and its sequelae (evaluation of 800 operations)].

answer: @entity1


abstract: OBJECTIVE: A systematic review of the literature to evaluate the clinical outcome of cochlear implantation for @entity0 with @entity3 ( @entity3 ) or @entity2 ( @entity2 ). DATA SOURCES: We searched the PubMed, Embase, Cochrane Library, and CINAHL databases from their inception up to December 10, 2013 for @entity3 or @entity2 and cochlear implantation or their synonyms. STUDY SELECTION: In total, 781 articles were retrieved, of which 15 satisfied the eligibility criteria. Our outcomes of interest were speech perception in noise, sound localization, quality of life (QoL), and @entity1 . DATA EXTRACTION: Critical appraisal showed that six studies reported on less than five @entity0 or that they carried a low directness of evidence or a high risk of bias. Therefore, we extracted the data of nine studies (n = 112). @entity0 numbers, age, duration of @entity3 , classification of @entity3 , pure tone audiometry, follow-up duration, and outcome measurements were extracted from all nine articles. DATA SYNTHESIS: Because of large heterogeneity between studies, we were not able to pool data in a meta-analysis. We therefore summarized the results of the studies specified per outcome. CONCLUSION: There are no high-level-of-evidence studies concerning cochlear implantation in @entity0 with @entity3 or @entity2 . Current literature suggests important benefits of cochlear implantation regarding sound localization, QoL, and @entity1 . Varying results were reported for speech perception in noise, possibly caused by the large clinical heterogeneity between studies. Larger and high-quality studies are certainly warranted.

title: Cochlear Implantation for XXXX With Single-Sided Deafness or Asymmetrical Hearing Loss: A Systematic Review of the Evidence.

answer: @entity0


abstract: UNASSIGNED: Alterations in intracellular @entity1 concentration ([ @entity1 ]i) play a crucial role in fundamental cellular events from transcriptional regulation to migration and proliferation. The transient receptor potential (TRP) channels contribute to changes in [ @entity1 ]i by providing or modulating @entity1 entry pathways, as well as by releasing @entity1 from intracellular stores. On the basis of sequence homology, the TRP family can be divided into seven subfamilies: the TRPC ("canonical") family, the TRPV ("vanilloid") family, the TRPM ("melastatin") family, the TRPP ("polycystin") family, the TRPML ("mucolipin") family, the @entity5 ("ankyrin") family, and the TRPN ("NOMPC") family. In this review, we focus on the physiology and pathophysiology of @entity0 TRPC channels in the nervous system. Seven @entity0 TRPC proteins ( @entity4 -7) have been described and are widely distributed in the brain from early embryonic days till adulthood, with the exception of @entity6 . TRPC channels are nonselective @entity1 -permeable channels, which can be activated by G-protein-coupled receptors and receptor @entity3 kinases. These channels have been reported to act as essential cellular sensors in multiple processes during neuronal development, including neural stem cell proliferation and differentiation, neuronal survival, neurite outgrowth and axon path finding, and synaptogenesis. Not surprisingly, studies on these channels also provide new insights into underlying mechanisms of various @entity2 . The present review summarizes the expressions of all TRPC subtypes in different brain regions and different neural cell types, aiming to serve as a useful reference for future studies in this field. We also discuss the most updated evidence implicating involvement of TRPC channels in the generation of pathophysiological states in nervous system and their potentials as being promising targets for drug development.

title: TRPC Channels: Prominent Candidates of Underlying Mechanism in XXXX .

answer: @entity2


abstract: PURPOSE OF REVIEW: Cerebrospinal fluid (CSF) @entity2 is a rare entity that can arise from a variety of causes. Successful management has been reported using a variety of repair techniques. The goal of this study is to make recommendations on intraoperative and postoperative management of CSF fistulas across all causes. RECENT FINDINGS: Pooled analysis of case series reveals that free graft repairs are successful in closing most traumatic and iatrogenic CSF leaks. In contrast, multilayered, vascularized repairs are often required for large defects with high-flow leaks that communicate with a cistern and/or ventricles. Spontaneous CSF leaks are associated with @entity3 in the vast majority of cases, and when present, postoperative medical management is necessary for long-term success. SUMMARY: @entity0 with @entity2 require surgical repair to prevent life-threatening complications. Many techniques and materials are effective at achieving closure of CSF @entity1 across causes. Evidence suggests that @entity0 with high-flow CSF fistulas have improved outcomes with multilayered, vascularized repairs to decrease the risk of postoperative CSF leaks. @entity0 with @entity3 need long-term management of the underlying disease process.

title: Treatment of XXXX .

answer: @entity2


abstract: UNASSIGNED: In most mammals, prolonged @entity1 (e.g. bed-rest, limb casting or spaceflight) results in @entity3 of muscle fibres which is largely due to unregulated proteolysis. Although numerous proteolytic pathways are known to participate in @entity1 @entity3 , recent evidence suggests that activation of @entity2 -dependent @entity4 proteases (calpains) is required for disuse @entity3 in limb skeletal muscles. In contrast to typical models of @entity1 ( @entity0 and rodents), animals that experience natural bouts of chronic muscle inactivity, such as hibernating mammals and aestivating frogs, consistently exhibit limited or no change in skeletal muscle size. In the current study, we examined enzyme activity, protein abundance and gene expression levels of calpain isoforms in gastrocnemius muscle of the aestivating frog, Cyclorana alboguttata. We predicted that in aestivating C. alboguttata there would be a downregulation of the abundance, activity and gene expression of @entity6 and @entity7 . In contrast to our hypothesis, there was no significant decrease in the enzyme activity levels or the relative protein abundances of @entity6 and @entity7 . Similarly, gene expression assays (both qRT-PCR and RNA Seq data) indicated that calpains were unaffected by aestivation. Western blotting of 'muscle-specific' calpain 3, which is consistently downregulated during @entity5 , indicated that this isoform is present in C. alboguttata muscle where it appears to be in its autolysed state. The absence of any increase in enzyme activity, protein and mRNA abundance of calpains in aestivators is consistent with the protection of gastrocnemius muscle against uncontrolled proteolysis throughout aestivation.

title: Activity, abundance and expression of XXXX -activated proteases in skeletal muscle of the aestivating frog, Cyclorana alboguttata.

answer: @entity2


abstract: UNASSIGNED: Although tonsil surgery is one of the most frequent otorhinolaryngological procedures, not many population-based regional or country-wide studies are published on the incidence of @entity1 and its risk factors. 2,216 @entity0 underwent tonsil surgery in 2012 in Thuringia, a federal state in Germany. Most frequent indications were @entity6 (44  % of all cases), @entity5 (27  %), and @entity4 (20  %). 29  % of the @entity0 were <10  years of age. Most frequent methods of surgery were tonsillectomy (73  %) and tonsillotomy (19  %). 215 @entity0 (10  %) had 221 events of a @entity1 . Re-surgery for hemostasis was necessary in 137 @entity0 (6  %). The interval to re-surgery was 4.4      4.6  days. The re-surgery rate was 8, 0.2, and 15  % after tonsillectomy, tonsillotomy, and radical tonsillectomy, respectively. In cases of @entity6 , male gender (p  <  0.001), age >24.78  years (median; (p  =  0.018), and waiving of perioperative antibiotics (p  =  0.029) were independent factors associated with @entity3 . In cases of @entity4 tonsillectomy instead of tonsillotomy, the only significant risk factor was @entity1 (p  =  0.005). The overall incidence of tonsillar surgery was 87.6/100,000. The highest incidence was seen for @entity0 3-4  years of age with 862.7/100,000. In @entity0 <10  years, the incidence was always higher for @entity0 than for @entity0 . Throughout all age groups, a reverse gender relation was only seen, if surgery was indicated for @entity6 . We recommend establishing national guidelines for indication of tonsil surgery, especially of tonsillectomy, including recommendations for perioperative care to decrease variations in tonsil surgery rates and minimize @entity2 .

title: Population-based analysis of tonsil surgery and XXXX .

answer: @entity1


abstract: The surgical correction of vertical malpositions of the @entity0 eye has been made relatively safe and reliable by recent surgical techniques. The authors define this condition as @entity3 and review the etiology of this deformity in 38 recent consecutive cases that were surgically treated at the Craniofacial Anomalies Center of The University of Virginia. Some new and useful tests are described that are of value to the plastic surgeon in analysis of the @entity1 and in planning the appropriate surgical procedure to correct the vertical @entity4 of one or both eyes. Several cases are illustrated that describe the principal surgical methods of moving the eye up or down without @entity2 . The vertical eye shifts in this series have been in the range of 2 to 3 mm to over 22 mm. No @entity2 was produced by these corrections. The most common difficulties and complications of @entity3 corrections are described. The implications of this type of surgery in terms of visual physiology are suggested. The authors conclude that surgical @entity3 is possible, safe, and rewarding to the @entity0 . However, they advise that the correction is best performed in young @entity0 and by a specially trained team of plastic surgeons, neurosurgeons, and ophthalmologists.

title: XXXX --surgical correction.

answer: @entity3


abstract: BACKGROUND: Domain loss following damage-control laparotomy is a challenging problem many surgeons face. The authors recently developed trans-abdominal wall traction, which closed 100 percent of domain loss abdomens in the acute setting. They hypothesized that it can be used successfully in @entity0 with @entity1 . METHODS: From 2008 to 2013, 44 @entity0 with acute loss of domain and 10 with chronically @entity2 were enrolled in the open abdomen protocol with subsequent placement of the trans-abdominal wall traction device. RESULTS: @entity0 ' average age in the acute and chronic groups was 28.2 and 35.3 years and average body mass index was 26.4 and 32.4 kg/m2, respectively. @entity2 size was reduced with the first trans-abdominal wall traction insertion from 610.5 cm2 to 274.6 cm2 in the acute setting and from 598 cm2 to 236.9 cm2 in the chronic setting. Average time from damage-control laparotomy to device insertion was 12.9 days in the acute group and more than 3 years in the chronic group. Lost domain was achieved with an average of less than 2.5 trans-abdominal wall traction tightenings, correlating to 9.2 and 8.2 days in the acute and chronic groups, respectively. Enterocutaneous fistula occurrence was 9 percent in the acute group and 0 percent in the chronic group. CONCLUSIONS: All @entity0 were successfully closed after reestablishment of the lost domain. Trans-abdominal wall traction is an effective means of reestablishing abdominal domain and achieving primary abdominal wall closure in all @entity0 with @entity2 , both acute and chronic.

title: Trans-abdominal wall traction as a universal solution to the management of XXXX .

answer: @entity2


abstract: Backgrond/Aim: Recent evidence indicates that @entity2 is a hallmark of @entity1 . @entity1 -associated neutrophils (TANs) contribute to @entity1 invasion. However, whether TANs and @entity4 are related is unknown. Intranodal lymphatic vessel density (LVD) is significantly correlated with @entity1 progression, @entity4 in @entity3 . Herein, we investigated the effects of TANs in regional lymph nodes. MATERIALS AND METHODS: We investigated the association of the density of TANs in regional lymph nodes with clinicopathological features by immunohistochemistry. Furthermore, we examined the prognostic value of TANs in lymph nodes. RESULTS: The number of TANs in regional lymph nodes was positively correlated with intranodal LVD and micrometastases. @entity0 with higher cluster of differentiation 15(+) TAN counts had significantly poorer prognosis than those with lower counts. CONCLUSION: Our results suggest that TANs in regional lymph nodes promote the invasion of lymph nodes by @entity1 cells via augmentation of lymphangiogenesis and thereby contribute to @entity1 progression.

title: A positive correlation between neutrophils in regional lymph nodes and progression of XXXX .

answer: @entity3


abstract: AIM: This study was undertaken to examine the impact of radiation dose on pathological complete response (pCR) rates following neoadjuvant radiochemotherapy (N-RCT) for @entity6 ( @entity2 ). @entity0 AND METHODS: From 1988 to 2011, 218 @entity0 were treated with 30-30.6 Gy (1.8-2 Gy per fraction), 39.6-40 Gy (1.8-2 Gy per fraction) or 44-45 Gy (1.8-2 Gy per fraction) and concomitant cisplatin    5-fluorouracil ( @entity5 ), @entity3 + @entity5 or @entity5 alone. The most commonly used concomitant chemotherapy was continuous infusion of @entity5 -alone with a dose of 300 mg/m(2)/day during the whole course of treatment (n=111). To eliminate the dispersing effect of potentially different efficacy levels of these drug regimens on pCR, we excluded @entity0 with regimens other than @entity5 -alone. RESULTS: Histomorphological regression grade 1a (0% @entity1 ), 1b (<10% @entity1 ), 2 (10-50% @entity1 ) and 3 (>50% @entity1 ) was observed in 26 (23%), 24 (22%), 36 (32%) and 25 (23%) @entity0 , respectively. pCR was observed in 9 out of 71 (13%) @entity0 treated with 30 Gy-30.6 Gy, 13 of 34 (38%) @entity0 treated with 39.6-40 Gy and 4 of 6 (67%) @entity0 treated with 44-45 Gy (p=0.001). Median follow-up time from the start of N-RCT was 191 months (range=2-262 months). The estimated 5-year @entity4 ( @entity4 ) was 33% for the whole cohort. @entity4 at 5 years was 58% for @entity0 with pCR compared to 25% for @entity0 with less favorable response to N-RCT (p=0.009), respectively. CONCLUSION: The dose of radiation correlates significantly with the likelihood of achieving a pCR in stage II/III @entity6 @entity0 . Prospective randomized trials are required to definitively evaluate the impact of application of higher radiation doses on efficacy and safety/tolerability in the context of N-RCT on the clinical outcomes.

title: Association between radiation dose and pathological complete response after preoperative radiochemotherapy in esophageal XXXX .

answer: @entity6


abstract: OBJECTIVES:: To evaluate local control and survival in locally advanced @entity1 @entity0 who underwent a preoperative 2-week course of radiotherapy (RT) and to identify prognostic factors influencing the survival rate. METHODS:: We analyzed 377 consecutively treated @entity0 with locally advanced (T3/T4 or node positive) @entity1 . All @entity0 underwent a preoperative 2-week course of RT (30 Gy in 10 fractions) followed by curative surgery. @entity3 model was used to examine prognostic factors for the disease-free survival (DFS) and @entity2 ( @entity2 ) rates. The Statistical Analysis System software package, version 9.3, was used for analysis. RESULTS:: The median follow-up for all living @entity0 was 63.8 months (range, 5.1 to 131.7). The 5-year DFS and @entity2 rates were 64.5% (95% CI, 59.0-69.4) and 75.6% (95% CI, 70.5-80.0), respectively. The 5-year cumulative incidences of local recurrence and distant metastases were 5.4% (95% CI, 2.9-7.9) and 29.0% (95% CI, 23.9-30.1), respectively. The pathologic complete response rate was achieved in 17 @entity0 (4.5%). The Multivariate Cox @entity3 model showed that factors affecting DFS were the surgical technique, pre-RT pathologic grade, ypT, ypN, and comorbidity; and factors improving @entity2 were low anterior resection, low pre-RT grade, low ypT, and low ypN. CONCLUSIONS:: @entity0 treated with preoperative RT with 30 Gy in 10 fractions had similar local control, 5-year DFS and @entity2 to reported long course RT regimen. The surgical technique, pre-RT pathologic grade, ypT, and ypN seemed to affect the @entity2 . Further study on combining a 2-week course of preoperative RT with concurrent chemotherapy would be warranted.

title: Two-week Course of Preoperative Radiotherapy for Locally Advanced XXXX : 8 Years' Experience in a Single Institute.

answer: @entity1


abstract: PURPOSE: To evaluate the structure-function relationship between disc margin-based rim area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch's membrane opening-based horizontal rim width (BMO-HRW), minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer thickness (RNFLT) obtained with spectral-domain optical coherence tomography (SD-OCT), and @entity1 . METHODS: We examined 151 @entity2 @entity0 with CSLT, SD-OCT, and standard automated perimetry on the same day. Optic nerve head (ONH) and RNFL with SD-OCT were acquired relative to a fixed coordinate system (acquired image frame [AIF]) and to the eye-specific fovea-BMO center (FoBMO) axis. @entity1 were mapped to ONH and RNFL sectors with fixed Garway-Heath (VFGH) and @entity0 -specific (VFPS) maps customized for various biometric parameters. RESULTS: Globally and sectorally, the structure-function relationships between DM-RA and VFGH, BMO-HRWAIF and VFGH, and BMO-HRWFoBMO and VFPS were equally weak. The R(2) for the relationship between DM-RA and VFGH ranged from 0.1% (inferonasal) to 11% (superotemporal) whereas that between BMO-HRWAIF and VFGH ranged from 0.1% (nasal) to 10% (superotemporal). Relatively stronger global and sectoral structure-function relationships with BMO-MRWAIF and with BMO-MRWFoBMO were obtained. The R(2) between BMO-MRWAIF and VFGH ranged from 5% (nasal) to 30% (superotemporal), whereas that between BMO-MRWFoBMO and VFPS ranged from 5% (nasal) to 25% (inferotemporal). The structure-function relationship with RNFLT was not significantly different from that with BMO-MRW, regardless of image acquisition method. CONCLUSIONS: The structure-function relationship was enhanced with BMO-MRW compared with the other neuroretinal rim measurements, due mainly to its geometrically accurate properties.

title: Enhanced Structure-Function Relationship in XXXX With an Anatomically and Geometrically Accurate Neuroretinal Rim Measurement.

answer: @entity2


abstract: Therapeutic options for @entity0 with @entity2 ( @entity2 ) remain limited. In a multicenter, Phase II study, 65 @entity0 with histologically confirmed @entity2 received a biomodulatory regimen during the six-month core study. Treatment comprised daily doses of @entity5 , @entity6 , @entity7 , @entity8 and @entity3 . The primary endpoint was @entity4 response. Responders could enter an extension phase until disease progression or intolerable @entity1 occurred. Mean @entity4 was 45.3  ng/mL at baseline, and 77  % of @entity0 had a @entity4 doubling time <3  months. Of the 61 evaluable @entity0 , 37 @entity0 (60.6  %) responded or had stable disease and 23 of them (37.7  % of 61 @entity0 ) were @entity4 responders. Among the 23 responders mean @entity4 decreased from 278.9        784.1  ng/mL at baseline to 8.8        11.6  ng/mL at the final visit (week 24). The progression-free survival (PFS) was 467  days in the ITT population. Of the 947 adverse events, 57.6  % were suspected to be drug-related, 13.8  % led to dose adjustment or permanent discontinuation and 40.2  % required concomitant medication. This novel combination approach led to an impressive @entity4 response rate of 37.7  % in @entity2 @entity0 . The good @entity4 response and PFS rate combined with the manageable @entity1 profile suggest an alternative treatment option.

title: Biomodulatory Treatment of @entity0 with Castration-Resistant Prostate Cancer: A Phase II Study of @entity5 with @entity6 , XXXX , @entity3 and Low-Dose @entity8 .

answer: @entity7


abstract: Therapeutic options for @entity0 with @entity2 ( @entity2 ) remain limited. In a multicenter, Phase II study, 65 @entity0 with histologically confirmed @entity2 received a biomodulatory regimen during the six-month core study. Treatment comprised daily doses of @entity5 , @entity6 , @entity7 , @entity8 and @entity3 . The primary endpoint was @entity4 response. Responders could enter an extension phase until disease progression or intolerable @entity1 occurred. Mean @entity4 was 45.3  ng/mL at baseline, and 77  % of @entity0 had a @entity4 doubling time <3  months. Of the 61 evaluable @entity0 , 37 @entity0 (60.6  %) responded or had stable disease and 23 of them (37.7  % of 61 @entity0 ) were @entity4 responders. Among the 23 responders mean @entity4 decreased from 278.9        784.1  ng/mL at baseline to 8.8        11.6  ng/mL at the final visit (week 24). The progression-free survival (PFS) was 467  days in the ITT population. Of the 947 adverse events, 57.6  % were suspected to be drug-related, 13.8  % led to dose adjustment or permanent discontinuation and 40.2  % required concomitant medication. This novel combination approach led to an impressive @entity4 response rate of 37.7  % in @entity2 @entity0 . The good @entity4 response and PFS rate combined with the manageable @entity1 profile suggest an alternative treatment option.

title: Biomodulatory Treatment of @entity0 with Castration-Resistant Prostate Cancer: A Phase II Study of @entity5 with @entity6 , @entity7 , XXXX and Low-Dose @entity8 .

answer: @entity3


abstract: Therapeutic options for @entity0 with @entity2 ( @entity2 ) remain limited. In a multicenter, Phase II study, 65 @entity0 with histologically confirmed @entity2 received a biomodulatory regimen during the six-month core study. Treatment comprised daily doses of @entity5 , @entity6 , @entity7 , @entity8 and @entity3 . The primary endpoint was @entity4 response. Responders could enter an extension phase until disease progression or intolerable @entity1 occurred. Mean @entity4 was 45.3  ng/mL at baseline, and 77  % of @entity0 had a @entity4 doubling time <3  months. Of the 61 evaluable @entity0 , 37 @entity0 (60.6  %) responded or had stable disease and 23 of them (37.7  % of 61 @entity0 ) were @entity4 responders. Among the 23 responders mean @entity4 decreased from 278.9        784.1  ng/mL at baseline to 8.8        11.6  ng/mL at the final visit (week 24). The progression-free survival (PFS) was 467  days in the ITT population. Of the 947 adverse events, 57.6  % were suspected to be drug-related, 13.8  % led to dose adjustment or permanent discontinuation and 40.2  % required concomitant medication. This novel combination approach led to an impressive @entity4 response rate of 37.7  % in @entity2 @entity0 . The good @entity4 response and PFS rate combined with the manageable @entity1 profile suggest an alternative treatment option.

title: Biomodulatory Treatment of @entity0 with Castration-Resistant Prostate Cancer: A Phase II Study of @entity5 with @entity6 , @entity7 , @entity3 and Low-Dose XXXX .

answer: @entity8


abstract: Therapeutic options for @entity0 with @entity2 ( @entity2 ) remain limited. In a multicenter, Phase II study, 65 @entity0 with histologically confirmed @entity2 received a biomodulatory regimen during the six-month core study. Treatment comprised daily doses of @entity5 , @entity6 , @entity7 , @entity8 and @entity3 . The primary endpoint was @entity4 response. Responders could enter an extension phase until disease progression or intolerable @entity1 occurred. Mean @entity4 was 45.3  ng/mL at baseline, and 77  % of @entity0 had a @entity4 doubling time <3  months. Of the 61 evaluable @entity0 , 37 @entity0 (60.6  %) responded or had stable disease and 23 of them (37.7  % of 61 @entity0 ) were @entity4 responders. Among the 23 responders mean @entity4 decreased from 278.9        784.1  ng/mL at baseline to 8.8        11.6  ng/mL at the final visit (week 24). The progression-free survival (PFS) was 467  days in the ITT population. Of the 947 adverse events, 57.6  % were suspected to be drug-related, 13.8  % led to dose adjustment or permanent discontinuation and 40.2  % required concomitant medication. This novel combination approach led to an impressive @entity4 response rate of 37.7  % in @entity2 @entity0 . The good @entity4 response and PFS rate combined with the manageable @entity1 profile suggest an alternative treatment option.

title: Biomodulatory Treatment of @entity0 with Castration-Resistant Prostate Cancer: A Phase II Study of XXXX with @entity6 , @entity7 , @entity3 and Low-Dose @entity8 .

answer: @entity5


abstract: Therapeutic options for @entity0 with @entity2 ( @entity2 ) remain limited. In a multicenter, Phase II study, 65 @entity0 with histologically confirmed @entity2 received a biomodulatory regimen during the six-month core study. Treatment comprised daily doses of @entity5 , @entity6 , @entity7 , @entity8 and @entity3 . The primary endpoint was @entity4 response. Responders could enter an extension phase until disease progression or intolerable @entity1 occurred. Mean @entity4 was 45.3  ng/mL at baseline, and 77  % of @entity0 had a @entity4 doubling time <3  months. Of the 61 evaluable @entity0 , 37 @entity0 (60.6  %) responded or had stable disease and 23 of them (37.7  % of 61 @entity0 ) were @entity4 responders. Among the 23 responders mean @entity4 decreased from 278.9        784.1  ng/mL at baseline to 8.8        11.6  ng/mL at the final visit (week 24). The progression-free survival (PFS) was 467  days in the ITT population. Of the 947 adverse events, 57.6  % were suspected to be drug-related, 13.8  % led to dose adjustment or permanent discontinuation and 40.2  % required concomitant medication. This novel combination approach led to an impressive @entity4 response rate of 37.7  % in @entity2 @entity0 . The good @entity4 response and PFS rate combined with the manageable @entity1 profile suggest an alternative treatment option.

title: Biomodulatory Treatment of @entity0 with Castration-Resistant Prostate Cancer: A Phase II Study of @entity5 with XXXX , @entity7 , @entity3 and Low-Dose @entity8 .

answer: @entity6


abstract: Therapeutic options for @entity0 with @entity2 ( @entity2 ) remain limited. In a multicenter, Phase II study, 65 @entity0 with histologically confirmed @entity2 received a biomodulatory regimen during the six-month core study. Treatment comprised daily doses of @entity5 , @entity6 , @entity7 , @entity8 and @entity3 . The primary endpoint was @entity4 response. Responders could enter an extension phase until disease progression or intolerable @entity1 occurred. Mean @entity4 was 45.3  ng/mL at baseline, and 77  % of @entity0 had a @entity4 doubling time <3  months. Of the 61 evaluable @entity0 , 37 @entity0 (60.6  %) responded or had stable disease and 23 of them (37.7  % of 61 @entity0 ) were @entity4 responders. Among the 23 responders mean @entity4 decreased from 278.9        784.1  ng/mL at baseline to 8.8        11.6  ng/mL at the final visit (week 24). The progression-free survival (PFS) was 467  days in the ITT population. Of the 947 adverse events, 57.6  % were suspected to be drug-related, 13.8  % led to dose adjustment or permanent discontinuation and 40.2  % required concomitant medication. This novel combination approach led to an impressive @entity4 response rate of 37.7  % in @entity2 @entity0 . The good @entity4 response and PFS rate combined with the manageable @entity1 profile suggest an alternative treatment option.

title: Biomodulatory Treatment of XXXX with Castration-Resistant Prostate Cancer: A Phase II Study of @entity5 with @entity6 , @entity7 , @entity3 and Low-Dose @entity8 .

answer: @entity0


abstract: OBJECTIVE: To evaluate the use of topical @entity4 ( @entity5 ) 1% in the treatment of @entity2 ( @entity2 ). METHODS: Retrospective chart review from 2001 to 2012 identified 12 @entity0 (22 eyes) with @entity2 (mean  standard deviation [SD] age, 50.2  15.4 years; 75% female; 92% white) treated with @entity5 . Main outcome measures included @entity1 grade, visual acuity, concurrent corticosteroid (CS) therapy, effect on CS taper, and adverse effects. RESULTS: Mean  SD follow-up time was 11.7  9.7 months. Mean  SD time from diagnosis to @entity5 treatment initiation was 2.4  3.2 months. Mean  SD duration of @entity5 treatment was 5.8  2.8 months. Four @entity0 (33%) complained of @entity3 (n=2), redness (n=1), itching (n=1), and burning (n=1) but none discontinued treatment. Concurrent CSs were tapered off in all @entity0 after a mean  SD of 5.0  2.5 weeks. Mean  SD initial vision was 0.078  0.093 logMAR, whereas vision at final examination was 0.056  0.081 logMAR (P=0.02). Mean  SD initial @entity1 grade of 1.9  1.0 was significantly reduced to final grade of 0.7  0.9 (P=0.0002). Mean  SD time to initial @entity1 control in 9 @entity0 (75%) was 33.2  24.5 days. Two @entity0 (17%) switched to oral @entity5 because of lack of @entity1 control. CONCLUSIONS: Topical @entity5 1% is an effective and well-tolerated therapy that @entity1 and tapered topical CS in @entity0 with @entity2 . The use of @entity5 in such @entity0 warrants further investigation.

title: Topical XXXX 1% for the Treatment of @entity2 .

answer: @entity4


abstract: OBJECTIVE: To evaluate the use of topical @entity4 ( @entity5 ) 1% in the treatment of @entity2 ( @entity2 ). METHODS: Retrospective chart review from 2001 to 2012 identified 12 @entity0 (22 eyes) with @entity2 (mean  standard deviation [SD] age, 50.2  15.4 years; 75% female; 92% white) treated with @entity5 . Main outcome measures included @entity1 grade, visual acuity, concurrent corticosteroid (CS) therapy, effect on CS taper, and adverse effects. RESULTS: Mean  SD follow-up time was 11.7  9.7 months. Mean  SD time from diagnosis to @entity5 treatment initiation was 2.4  3.2 months. Mean  SD duration of @entity5 treatment was 5.8  2.8 months. Four @entity0 (33%) complained of @entity3 (n=2), redness (n=1), itching (n=1), and burning (n=1) but none discontinued treatment. Concurrent CSs were tapered off in all @entity0 after a mean  SD of 5.0  2.5 weeks. Mean  SD initial vision was 0.078  0.093 logMAR, whereas vision at final examination was 0.056  0.081 logMAR (P=0.02). Mean  SD initial @entity1 grade of 1.9  1.0 was significantly reduced to final grade of 0.7  0.9 (P=0.0002). Mean  SD time to initial @entity1 control in 9 @entity0 (75%) was 33.2  24.5 days. Two @entity0 (17%) switched to oral @entity5 because of lack of @entity1 control. CONCLUSIONS: Topical @entity5 1% is an effective and well-tolerated therapy that @entity1 and tapered topical CS in @entity0 with @entity2 . The use of @entity5 in such @entity0 warrants further investigation.

title: Topical @entity4 1% for the Treatment of XXXX .

answer: @entity2


abstract: Objective: To provide information on the role of pharmacists in nonsteroidal anti-inflammatory drug (NSAID) avoidance in high-risk @entity0 . Summary: Nonprescription analgesics such as @entity3 and naproxen are widely used by Americans. These nonsteroidal anti-inflammatory drugs (NSAIDs) are available in large quantities in pharmacies and also in wholesale stores, gas stations, and convenience stores. In addition, more than 111 million @entity0 use prescription NSAIDs each year, including many older Americans. NSAIDs may seem innocuous, but they carry a significant risk of disrupting blood flow to the kidneys and thus precipitating @entity2 ( @entity2 ). Episodes of @entity2 can lead to costly hospitalizations and long-term consequences such as new-onset @entity1 ( @entity1 ) or more rapid progression of existing @entity1 . Most cases of NSAID-induced @entity2 can be avoided by recognizing high-risk @entity0 and counseling them on appropriate use of these medications. Community pharmacy-based NSAID counseling and education at the point of prescription dispensing or nonprescription purchase could complement and augment NSAID-induced @entity2 education provided by other members of the health care team to high-risk @entity0 . Conclusion: NSAID use is widespread and severely compromises effective renal perfusion in high-risk @entity0 . The community pharmacist can play a pivotal role in NSAID avoidance education to prevent potential episodes of @entity2 that have long-term consequences for @entity0 .

title: Keeping kidneys safe: The pharmacist's role in NSAID avoidance in high-risk XXXX .

answer: @entity0


abstract: Thirty consecutive cases of localized primary @entity6 's @entity3 (PNHLB) were treated in a 10-year period at the Istituto Ortopedico Rizzoli with localized radiation (4 cases) and localized radiation and adjuvant chemotherapy (26 cases). The doses of radiation varied from 3000-4500 rad. A variety of staging procedures evolving with new diagnostic techniques over the 10 years were performed. Adjuvant chemotherapy comprised two different regimens of @entity5 , @entity2 and @entity4 . Twenty-four of the 26 @entity0 (92%) have been free of disease with a median follow-up of 75.5 months (18-144 months). Two @entity0 developed meningeal involvement and one @entity0 , treated with radiation therapy only, developed a local recurrence. The results are compared to the management of 68 @entity7 @entity0 treated during the same period. Here, higher doses of localized radiation therapy (approximately 5000 rad) and similar adjuvant chemotherapy were administered. The survival was 32% (22/68) with a higher incidence of local recurrence (21%). These data indicate that PNHLB should be considered a separate entity from @entity7 and can be treated successfully with lower doses of radiation to the @entity1 and adjuvant chemotherapy. The observations are also compared to a variety of other biological characteristics of @entity7 . Since only two @entity0 developed meningeal relapse, our experience does not permit a firm recommendation for routine prophylactic treatment of the central nervous system in PNHLB.

title: Staging, therapy and prognosis of primary @entity6 's XXXX and a comparison of results with localized @entity7 : ten years experience at the Istituto Ortopedico Rizzoli.

answer: @entity3


abstract: Thirty consecutive cases of localized primary @entity6 's @entity3 (PNHLB) were treated in a 10-year period at the Istituto Ortopedico Rizzoli with localized radiation (4 cases) and localized radiation and adjuvant chemotherapy (26 cases). The doses of radiation varied from 3000-4500 rad. A variety of staging procedures evolving with new diagnostic techniques over the 10 years were performed. Adjuvant chemotherapy comprised two different regimens of @entity5 , @entity2 and @entity4 . Twenty-four of the 26 @entity0 (92%) have been free of disease with a median follow-up of 75.5 months (18-144 months). Two @entity0 developed meningeal involvement and one @entity0 , treated with radiation therapy only, developed a local recurrence. The results are compared to the management of 68 @entity7 @entity0 treated during the same period. Here, higher doses of localized radiation therapy (approximately 5000 rad) and similar adjuvant chemotherapy were administered. The survival was 32% (22/68) with a higher incidence of local recurrence (21%). These data indicate that PNHLB should be considered a separate entity from @entity7 and can be treated successfully with lower doses of radiation to the @entity1 and adjuvant chemotherapy. The observations are also compared to a variety of other biological characteristics of @entity7 . Since only two @entity0 developed meningeal relapse, our experience does not permit a firm recommendation for routine prophylactic treatment of the central nervous system in PNHLB.

title: Staging, therapy and prognosis of primary XXXX 's @entity3 and a comparison of results with localized @entity7 : ten years experience at the Istituto Ortopedico Rizzoli.

answer: @entity6


abstract: Thirty consecutive cases of localized primary @entity6 's @entity3 (PNHLB) were treated in a 10-year period at the Istituto Ortopedico Rizzoli with localized radiation (4 cases) and localized radiation and adjuvant chemotherapy (26 cases). The doses of radiation varied from 3000-4500 rad. A variety of staging procedures evolving with new diagnostic techniques over the 10 years were performed. Adjuvant chemotherapy comprised two different regimens of @entity5 , @entity2 and @entity4 . Twenty-four of the 26 @entity0 (92%) have been free of disease with a median follow-up of 75.5 months (18-144 months). Two @entity0 developed meningeal involvement and one @entity0 , treated with radiation therapy only, developed a local recurrence. The results are compared to the management of 68 @entity7 @entity0 treated during the same period. Here, higher doses of localized radiation therapy (approximately 5000 rad) and similar adjuvant chemotherapy were administered. The survival was 32% (22/68) with a higher incidence of local recurrence (21%). These data indicate that PNHLB should be considered a separate entity from @entity7 and can be treated successfully with lower doses of radiation to the @entity1 and adjuvant chemotherapy. The observations are also compared to a variety of other biological characteristics of @entity7 . Since only two @entity0 developed meningeal relapse, our experience does not permit a firm recommendation for routine prophylactic treatment of the central nervous system in PNHLB.

title: Staging, therapy and prognosis of primary @entity6 's @entity3 and a comparison of results with localized XXXX : ten years experience at the Istituto Ortopedico Rizzoli.

answer: @entity7


abstract: Micromonospora is a Gram positive bacterium that can be isolated from @entity2 fixing nodules from healthy leguminous plants, where they could be beneficial to the plant. Their plant growth promoting activity in legume and non-legume plants has been previously demonstrated. The present study explores the ability of Micromonospora strains to control fungal pathogens and to stimulate plant immunity. Micromonospora strains isolated from surface sterilized nodules of alfalfa showed in vitro antifungal activity against several pathogenic fungi. Moreover, root inoculation of @entity0 plants with these Micromonospora strains effectively reduced leaf infection by the fungal pathogen @entity4 , despite spatial separation between both microorganisms. This induced systemic resistance, confirmed in different @entity0 cultivars, is long lasting. Gene expression analyses evidenced that Micromonospora stimulates the plant capacity to activate defense mechanisms upon pathogen attack. The defensive response of @entity0 plants inoculated with Micromonospora spp. differs from that of non-inoculated plants, showing a stronger induction of @entity3 -regulated defenses when the plant is challenged with a pathogen. The hypothesis of jasmonates playing a key role in this defense priming effect was confirmed using defense-impaired @entity0 mutants, since the @entity1 was unable to display a long term induced resistance upon Micromonospora spp. inoculation. In conclusion, nodule isolated Micromonospora strains should be considered excellent candidates as biocontrol agents as they combine both direct antifungal activity against plant pathogens and the ability to prime plant immunity.

title: Induced systemic resistance against XXXX by Micromonospora strains isolated from root nodules.

answer: @entity4


abstract: A procedure was developed for separating antigens associated with a saline extract of @entity5 serotype 1. Seven antigens were identified by immunoelectrophoresis to be associated with the extract. The extract was subjected to preparative isoelectrofocusing in a pH range of 3-10. The majority of extracted proteins were found to have pI's of 4-6, whereas the @entity3 antigen(s) were distributed over a pI range of 3.0-8.0. The fractions that were of interest were pooled and refocused in a narrower pH range to improve resolution of the protein antigens. Specific antigens from defined pH ranges were pooled to form 6 antigen groups. These antigen groups were examined further by immunoelectrophoresis, analytical isoelectrofocusing, and @entity1 - @entity4 gel electrophoresis. The molecular weights of the proteins found in the capsular extracts ranged from 33 k to greater than 80 k. Injection of @entity0 with capsular extract or antigen Groups 1-6 in Freund's incomplete adjuvant resulted in a serum antibody response to the various antigens as detected by an enzyme-linked immunosorbent assay. Significant protection (P less than 0.05) against challenge with virulent @entity5 was seen in @entity0 injected with antigen Groups 2 and 4. Six @entity2 were immunized with saline extract. These @entity2 had greater resistance to experimental pneumonic @entity6 than did 6 non-vaccinated calves. A serum antibody response to the crude extract and to each antigen group was detected in vaccinated @entity2 by an enzyme-linked immunosorbant assay.

title: XXXX : purification of saline-extractable proteins by isoelectrofocusing.

answer: @entity5


abstract: BACKGROUND: Proton pump inhibitors (PPIs) cause @entity2 and are an underappreciated cause of @entity1 . We examined the risk of @entity1 and acute @entity2 in a large population of older @entity0 receiving PPIs. METHODS: We conducted a population-based study involving Ontario residents aged 66 years and older who initiated PPI therapy between Apr. 1, 2002, and Nov. 30, 2011. We used propensity score matching to establish a highly comparable reference group of control @entity0 . The primary outcome was hospital admission with @entity1 within 120 days, and a secondary analysis examined acute @entity2 . We used Cox proportional hazards regression to adjust for differences between groups. RESULTS: We studied 290  592 individuals who commenced PPI therapy and an equal number of matched controls. The rates of @entity1 (13.49 v. 5.46 per 1000 @entity0 -years, respectively; hazard ratio [HR] 2.52, 95% CI 2.27 to 2.79) and acute @entity2 (0.32 vs. 0.11 per 1000 @entity0 -years; HR 3.00, 95% CI 1.47 to 6.14) were higher among @entity0 given PPIs than among controls. INTERPRETATION: In our study population of older adults, those who started PPI therapy had an increased risk of @entity1 and acute @entity2 . These are potentially reversible conditions that may not be readily attributed to drug treatment. Clinicians should appreciate the risk of acute @entity2 during treatment with PPIs, monitor @entity0 appropriately and discourage the indiscriminate use of these drugs.

title: Proton pump inhibitors and the risk of XXXX in older @entity0 : a population-based cohort study.

answer: @entity1


abstract: BACKGROUND: Proton pump inhibitors (PPIs) cause @entity2 and are an underappreciated cause of @entity1 . We examined the risk of @entity1 and acute @entity2 in a large population of older @entity0 receiving PPIs. METHODS: We conducted a population-based study involving Ontario residents aged 66 years and older who initiated PPI therapy between Apr. 1, 2002, and Nov. 30, 2011. We used propensity score matching to establish a highly comparable reference group of control @entity0 . The primary outcome was hospital admission with @entity1 within 120 days, and a secondary analysis examined acute @entity2 . We used Cox proportional hazards regression to adjust for differences between groups. RESULTS: We studied 290  592 individuals who commenced PPI therapy and an equal number of matched controls. The rates of @entity1 (13.49 v. 5.46 per 1000 @entity0 -years, respectively; hazard ratio [HR] 2.52, 95% CI 2.27 to 2.79) and acute @entity2 (0.32 vs. 0.11 per 1000 @entity0 -years; HR 3.00, 95% CI 1.47 to 6.14) were higher among @entity0 given PPIs than among controls. INTERPRETATION: In our study population of older adults, those who started PPI therapy had an increased risk of @entity1 and acute @entity2 . These are potentially reversible conditions that may not be readily attributed to drug treatment. Clinicians should appreciate the risk of acute @entity2 during treatment with PPIs, monitor @entity0 appropriately and discourage the indiscriminate use of these drugs.

title: Proton pump inhibitors and the risk of @entity1 in older XXXX : a population-based cohort study.

answer: @entity0


abstract: AIM AND OBJECTIVE: The main purpose of this study is to identify the myocardial changes in severely malnourished @entity0 . MATERIALS AND METHODS: This prospective, observational study, conducted for a period of 1   year, enrolled 200 @entity0 (120 males and 80 females) between 6   months and 5   years of age with severe @entity2 , according to the criteria of the World Health Organization. The parents were duly informed, the study was explained and written consent was obtained. A random selection of cases was carried out, and they were further divided into five groups according to their age as follows: <1, 1-2, 2-3, 3-4, and 4-5   years. Electrocardiograms (ECGs) were taken at the time of admission for all the cases and the control group and were taken again after nutritional therapy either at the time of discharge or after a fortnight. The differences were then compared. RESULTS: On admission, 32% of cases had flat P-wave, out of which 75% reverted to normal with therapy. Similarly, 84% of cases had increased corrected QT interval at the time of admission. ST segment was depressed only in 8% of cases. 88% of cases had altered (flat to depressed) T wave at the time of admission. With the help of nutritional supplementation, all these abnormalities were back to a normal level at the time of discharge. CONCLUSION: Electrocardiographic changes may be of help in assessing the severity and prognosis of severe acute @entity1 . The reversibility of ECG changes with dietary treatment suggests that the cardiac changes are not permanent in nature and may not affect adult life if the @entity1 is corrected. The cardiac status as denoted by heart rate remained the same even after a fortnight, suggesting that prolonged therapy and assessment of cardiac status is warranted even after fortnight therapy.

title: To Identify Myocardial Changes in Severely Malnourished XXXX : A Prospective Observational Study.

answer: @entity0


abstract: To investigate the factors responsible for the morning rise in blood pressure (BP) in @entity1 ( @entity1 ) we examined a group of 253 consecutive snorers or @entity1 @entity0 . On the basis of their AHI the @entity0 were classified in four groups. BP was measured on the evening before sleep onset and on the following morning after 15 min of rest by a finger arterial pressure device (Finapres). In 150 subjects BP was monitored during the night by a Finapres device. In the morning BP increased in the @entity0 group with an average difference of 9.9 +/- 0.5 mmHg for systolic ( @entity4 ) and 9.9 +/- 0.4 mmHg for diastolic pressure ( @entity5 ). The increase was significant in snorers and @entity1 @entity0 without differences between groups. The morning rise in @entity4 was related to diurnal values of @entity4 , age and AHI whereas the time spent in @entity2 and the diurnal values of @entity5 significantly contributed to the @entity5 increase. In the subgroup of 150 @entity0 in whom BP was analyzed during sleep, the awakening increase was related to the absolute BP value during sleep and to the BP changes from wakefulness to sleep. The magnitude of the BP changes from evening to morning was not dependent on the degree of BP variability during sleep. We conclude that the awakening increase in BP in @entity0 with snoring or @entity1 may be mediated by the setting of pressure response to @entity2 or to mechanical effort during sleep. Anthropometric variables and diurnal cardiovascular setting may play an additional role in modulating the final pressure response to upper @entity3 .

title: Determinants of the awakening rise in systemic blood pressure in XXXX .

answer: @entity1


abstract: Currently numerous clinical trials are in progress utilizing intracarotid (i.c.) @entity6 (BCNU) for the treatment of @entity1 based upon the proposed focal nature of these @entity0 and the assumption that the i.c. route delivers higher levels of drug to the @entity0 . To date, however, increased efficacy in an animal model has not been clearly demonstrated for the i.c. delivery of BCNU. We have evaluated the dose-response curve for the i.v. and i.c. administration of @entity6 in a commonly utilized experimental @entity4 model, the 9L @entity2 @entity5 . An initial @entity3 trial utilizing the i.p. 10% lethal dose (LD10) of BCNU by the i.v. and i.c. routes failed to demonstrate any significance in @entity3 between the two routes. Tumor-bearing animals were then treated on Day 15-16 after @entity0 inoculations with 1, 10, 25, 50, 75, and 100% of the LD10 dose by either the i.v. or the i.c. route. Both i.v. and i.c. BCNU gave maximum survival increases at 75-100% LD10 doses, and there was no therapeutic advantage seen from i.c. delivery. However, at 50% of the LD10 dose (6.65 mg/kg), triplicate experiments demonstrated that the i.c. but not the i.v. dose maintained maximum efficacy equivalent to 100% of the LD10 given either i.v. or i.c. When the dose was reduced to 25% of the LD10 dose (3.33 mg/kg), two of three experiments showed efficacy of the i.c. delivery of this lower drug dosage to be equivalent to 100% of the LD10 given i.v. or i.c. The i.v. dosage resulted in a significant reduction in survival in all three trials. At 10% of the LD10 dose (1.30 mg/kg), neither the i.v. nor the i.c. administration retained equivalent efficacy to 100% of the LD10. However, in one of two trials, the i.c. groups had statistically better survival than controls, while in neither experiment was any advantage over controls seen in the i.v. treated groups. At 1% of the LD10 dose, neither the i.v. nor the i.c. route demonstrated any therapeutic efficacy. From our data, the advantage of the i.c. delivery of BCNU in the intracranial 9L @entity2 @entity5 appears to be in the fact that significantly lower dosages than those given i.v. may be utilized to achieve equivalent survival with potentially less systemic @entity3 .

title: Comparison of intravenous versus intracarotid therapy with XXXX in a @entity2 @entity4 model.

answer: @entity6


abstract: Currently numerous clinical trials are in progress utilizing intracarotid (i.c.) @entity6 (BCNU) for the treatment of @entity1 based upon the proposed focal nature of these @entity0 and the assumption that the i.c. route delivers higher levels of drug to the @entity0 . To date, however, increased efficacy in an animal model has not been clearly demonstrated for the i.c. delivery of BCNU. We have evaluated the dose-response curve for the i.v. and i.c. administration of @entity6 in a commonly utilized experimental @entity4 model, the 9L @entity2 @entity5 . An initial @entity3 trial utilizing the i.p. 10% lethal dose (LD10) of BCNU by the i.v. and i.c. routes failed to demonstrate any significance in @entity3 between the two routes. Tumor-bearing animals were then treated on Day 15-16 after @entity0 inoculations with 1, 10, 25, 50, 75, and 100% of the LD10 dose by either the i.v. or the i.c. route. Both i.v. and i.c. BCNU gave maximum survival increases at 75-100% LD10 doses, and there was no therapeutic advantage seen from i.c. delivery. However, at 50% of the LD10 dose (6.65 mg/kg), triplicate experiments demonstrated that the i.c. but not the i.v. dose maintained maximum efficacy equivalent to 100% of the LD10 given either i.v. or i.c. When the dose was reduced to 25% of the LD10 dose (3.33 mg/kg), two of three experiments showed efficacy of the i.c. delivery of this lower drug dosage to be equivalent to 100% of the LD10 given i.v. or i.c. The i.v. dosage resulted in a significant reduction in survival in all three trials. At 10% of the LD10 dose (1.30 mg/kg), neither the i.v. nor the i.c. administration retained equivalent efficacy to 100% of the LD10. However, in one of two trials, the i.c. groups had statistically better survival than controls, while in neither experiment was any advantage over controls seen in the i.v. treated groups. At 1% of the LD10 dose, neither the i.v. nor the i.c. route demonstrated any therapeutic efficacy. From our data, the advantage of the i.c. delivery of BCNU in the intracranial 9L @entity2 @entity5 appears to be in the fact that significantly lower dosages than those given i.v. may be utilized to achieve equivalent survival with potentially less systemic @entity3 .

title: Comparison of intravenous versus intracarotid therapy with @entity6 in a @entity2 XXXX model.

answer: @entity4