abstract: UNASSIGNED: Objective. To evaluate the forward shifting of cervical spinal cords in different segments of @entity0 with @entity1 to determine whether the disease is self-limiting. Methods. This study was performed on 11 healthy subjects and 64 @entity0 . According to the duration, the @entity0 were divided into 5 groups ( <=1 year, 1-2 years, 2-3 years, 3-4 years, and >= 4 years). Cervical magnetic resonance imaging (MRI) of flexion and conventional position was performed. The distances between the posterior edge of the spinal cord and the cervical spinal canal (X), the anterior and posterior wall of the cervical spinal canal (Y), and the anterior-posterior (A) and the transverse diameter (B) of spinal cord cross sections were measured at different cervical spinal segments (C4 to T1). Results. In cervical flexion position, a significant increase in X/Y of C4-5 segments was found in groups 2-5, the @entity2 and C6-7 segments in groups 1-5, and the C7-T1 segments in group 5 (P < 0.05). The degree of the increased X/Y and cervical flexion X/Y of @entity2 segments were different among the 5 groups (P < 0.05), which was likely due to rapid increases in X/Y during the course of @entity1 . Conclusion. The X/Y change progression indicates that @entity1 may not be self-limiting.

title: The Quantitative Assessment of Imaging Features for the Study of XXXX Progression.

answer: @entity1


abstract: UNASSIGNED: @entity2 modulation in the dorsal raphe nucleus (DRN) plays an important role in sleep-wake regulation. Calmodulin-dependent kinase II (CaMKII) is an important signal-transducing molecule that is activated by @entity2 . The present study investigated the effects of intracellular @entity2 /CaMKII signaling in the DRN on sleep-wake states in @entity1 . Maximum and minimum CaMKII phosphorylation was detected at Zeitgeber time 21 (ZT 21; wakefulness state) and ZT 3 (sleep state), respectively, across the light-dark rhythm in the DRN in @entity1 . Six-hour sleep deprivation significantly reduced CaMKII phosphorylation in the DRN. Microinjection of the CAMKII activation inhibitor @entity4 (5 or 10 nmol) into the DRN suppressed wakefulness and enhanced @entity3 ( @entity3 ) and non-REM sleep (NREMS). Application of a high dose of @entity4 (10 nmol) increased @entity0 ( @entity0 ) time, @entity0 bouts, the mean duration of @entity0 , the percentage of @entity0 relative to total sleep, and delta power density during NREMS. Microinjection of @entity5 (50 nmol) in the DRN increased CaMKII phosphorylation and decreased NREMS, @entity0 , and @entity3 . @entity4 abolished the inhibitory effects of @entity5 on NREMS, @entity0 , and @entity3 . These data indicate a novel wake-promoting and sleep-suppressing role for the @entity2 /CaMKII signaling pathway in DRN neurons. This article is protected by copyright. All rights reserved.

title: Phosphorylation of CaMKII in the XXXX dorsal raphe nucleus plays an important role in sleep-wake regulation.

answer: @entity1


abstract: This study examined the effects on proximal tubule morphology of blocking single @entity5 with paraffin wax for one day, one week, or one month in the @entity0 . Proximal tubule lumens were blocked with a short column of wax using micropuncture. Chronically blocked and control (normal) tubules were fixed by either intravascular or intraluminal perfusion of @entity3 solution. Proximal tubule segments downstream to the wax block were examined by light and transmission electron microscopy. Intraluminal @entity4 dye, serial sectioning, and nephron microdissection techniques were used to identify @entity5 . One day after obstruction, all proximal tubule cells downstream to the block were injured. Some recovery was seen. S1 and S2 segments showed more severe damage than S3 segments. @entity4 , which normally is excluded from cells, entered the cytoplasm of some damaged S1-S2 cells. After one week of obstruction, the tubule appeared to have reconstituted itself, but cells were less differentiated than normal. One month after obstruction, blocked tubules were atrophied. Tubule cells were simplified and were surrounded by a thickened basement membrane. The results suggest that prolonged proximal tubule blockade produces injury and @entity2 of the proximal tubule probably due to @entity1 and interruption of normal reabsorptive activity.

title: Proximal tubule morphology after single nephron obstruction in the XXXX kidney.

answer: @entity0


abstract: 21 @entity0 with @entity7 of at least 70% and 21 @entity0 with @entity7 and additional intramural anterior wall @entity5 were studied. 20 @entity0 without @entity1 or after successful transluminal coronary angioplasty and 18 @entity0 with intramural anterior wall @entity5 after successful transluminal dilatation of the LAD (remaining stenosis maximal 30%) served as controls. The normal range of global and regional left ventricular ejection fraction response to exercise was defined based on the data of 25 further @entity0 without relevant @entity2 . Thus, a decrease in global ejection fraction and regional wall motion abnormalities were judged pathological. All @entity0 were comparable with respect to age, ejection fraction at rest and work load. @entity4 could be detected by the exercise ECG in 81% of all @entity0 without @entity5 and in 71% of @entity0 with @entity5 . The corresponding values for global left ventricular ejection fraction were 76% and 81%, respectively, and for regional ejection fraction 95% in both groups. No false-positive exercise ECGs were observed in the healthy controls and 2 (11%) in the corresponding group with intramural @entity5 . The global ejection fraction was pathological in 1 (5%) healthy subject without @entity5 and in 3 (17%) corresponding @entity0 with @entity5 . Sectorial analysis revealed 5 and 22%, respectively. Our findings suggest that the exercise ECG has a limited sensitivity to detect @entity4 in @entity0 with isolated @entity7 and intramural @entity3 . Radionuclide ventriculography yields pathological values more often; however, @entity6 occur more frequently.

title: [Comparison of effort-ECG and radionuclide ventriculography in relation to the detection of XXXX in isolated stenoses of the anterior interventricular branch].

answer: @entity4


abstract: Symptomatic @entity8 of the sural nerve are a rare but significant cause of @entity2 and debilitation in athletes. Presentation is usually in the form of @entity4 and @entity3 or paresthesias of the lateral foot and ankle. Treatment traditionally ranges from conservative measures, such as removing all external compressive forces, to administration of nonsteroidal anti-inflammatory drugs, @entity6 , tricyclic antidepressants, antiepileptics, or topical anesthetics. This article reports a case of sural nerve entrapment in a 34-year-old male triathlete with a history of recurrent training-induced right-sided gastrocnemius strains. The @entity0 presented with @entity5 in the right lateral foot and ankle that had persisted for 3 months, after he was treated unsuccessfully with extensive nonoperative measures, including anti-inflammatory drugs, activity modification, and a dedicated physical therapy program of stretching and strengthening. Orthopedic assessment showed worsening @entity2 with forced passive dorsiflexion and manual pressure applied over the distal aspect of the gastrocnemius. Plain radiographs showed normal findings, but in-office ultrasound imaging showed evidence of sural nerve entrapment with @entity1 and @entity7 formation in the absence of gastrocnemius or soleus pathology. Percutaneous ultrasound-guided hydrodissection of the sural nerve at the area of symptomatic @entity1 was performed the same day. The @entity0 had complete relief of symptoms and full return to the preinjury level of participation in competitive sports. This case report shows that hydrodissection, when performed by an experienced physician, can be an effective, minimally invasive technique for neurolysis in the setting of sural nerve entrapment, resulting in improvement in clinical symptoms. [Orthopedics. 2015; 38(11):e1046-e1050.].

title: Percutaneous Ultrasound-Guided Hydrodissection of a Symptomatic Sural XXXX .

answer: @entity8


abstract: Cerebral hemodynamic and metabolic changes, occurring during delayed hypoperfusion following transient @entity6 , and the influence of treatment with @entity8 plus @entity9 were studied in mongrel @entity3 . 10 min of transient @entity6 was induced by bilateral clamping of both carotid and vertebral arteries. After declamping, the mean time necessary until cerebral venous @entity7 (cvPO2) reached a value of 3.6 kPa, threshold for tissue @entity5 , was 80 min. At this time (T0), venous cerebral blood flow (vCBF) and cerebral perfusion pressure (Perf P) were below (60 and 20%, respectively) preischemic values, while cerebral vascular resistance (CVR) and @entity0 and @entity4 extraction rates increased despite a normal cerebral @entity0 consumption (CMRO2). At T0 ventilatory assistance without (control group) or with (treated group) intravenous infusion of @entity8 plus @entity9 was applied for 110 min. Between T0 and T110 min, 2 @entity3 died in the control group. During this period vCBF decreased by more than 60% in the control group while it slightly increased in the treated group. A strong decrease in Perf P (40%) and increase in CVR (140%) was observed in the control group while in the treated group Perf P and CVR slightly decreased (14 and 35%, respectively). CMRO2 decreased by 60% in the control group but remained within the normal range in the treated group. The fact that cvPO2 remained constantly below the initial value of 3.6 kPa in the control group and, on contrary, above this value in the group infused with @entity9 plus @entity8 indicates that the vCBF improvement leads to an increase in @entity0 supply and is involved in the keeping of the adequacy between flow and metabolism. Our results support the hypothesis that the @entity1 may play an important role in the acute prognosis of @entity2 . They clearly indicate that early cerebral resuscitation by infusion of @entity8 plus @entity9 , maintaining @entity0 availability and CBF above initial thresholds, should improve the long-term neurological outcome.

title: Curative effect of an @entity8 - XXXX combination in the postischemic syndrome following transient @entity6 in @entity3 .

answer: @entity9


abstract: Cerebral hemodynamic and metabolic changes, occurring during delayed hypoperfusion following transient @entity6 , and the influence of treatment with @entity8 plus @entity9 were studied in mongrel @entity3 . 10 min of transient @entity6 was induced by bilateral clamping of both carotid and vertebral arteries. After declamping, the mean time necessary until cerebral venous @entity7 (cvPO2) reached a value of 3.6 kPa, threshold for tissue @entity5 , was 80 min. At this time (T0), venous cerebral blood flow (vCBF) and cerebral perfusion pressure (Perf P) were below (60 and 20%, respectively) preischemic values, while cerebral vascular resistance (CVR) and @entity0 and @entity4 extraction rates increased despite a normal cerebral @entity0 consumption (CMRO2). At T0 ventilatory assistance without (control group) or with (treated group) intravenous infusion of @entity8 plus @entity9 was applied for 110 min. Between T0 and T110 min, 2 @entity3 died in the control group. During this period vCBF decreased by more than 60% in the control group while it slightly increased in the treated group. A strong decrease in Perf P (40%) and increase in CVR (140%) was observed in the control group while in the treated group Perf P and CVR slightly decreased (14 and 35%, respectively). CMRO2 decreased by 60% in the control group but remained within the normal range in the treated group. The fact that cvPO2 remained constantly below the initial value of 3.6 kPa in the control group and, on contrary, above this value in the group infused with @entity9 plus @entity8 indicates that the vCBF improvement leads to an increase in @entity0 supply and is involved in the keeping of the adequacy between flow and metabolism. Our results support the hypothesis that the @entity1 may play an important role in the acute prognosis of @entity2 . They clearly indicate that early cerebral resuscitation by infusion of @entity8 plus @entity9 , maintaining @entity0 availability and CBF above initial thresholds, should improve the long-term neurological outcome.

title: Curative effect of an @entity8 - @entity9 combination in the postischemic syndrome following transient XXXX in @entity3 .

answer: @entity6


abstract: Cerebral hemodynamic and metabolic changes, occurring during delayed hypoperfusion following transient @entity6 , and the influence of treatment with @entity8 plus @entity9 were studied in mongrel @entity3 . 10 min of transient @entity6 was induced by bilateral clamping of both carotid and vertebral arteries. After declamping, the mean time necessary until cerebral venous @entity7 (cvPO2) reached a value of 3.6 kPa, threshold for tissue @entity5 , was 80 min. At this time (T0), venous cerebral blood flow (vCBF) and cerebral perfusion pressure (Perf P) were below (60 and 20%, respectively) preischemic values, while cerebral vascular resistance (CVR) and @entity0 and @entity4 extraction rates increased despite a normal cerebral @entity0 consumption (CMRO2). At T0 ventilatory assistance without (control group) or with (treated group) intravenous infusion of @entity8 plus @entity9 was applied for 110 min. Between T0 and T110 min, 2 @entity3 died in the control group. During this period vCBF decreased by more than 60% in the control group while it slightly increased in the treated group. A strong decrease in Perf P (40%) and increase in CVR (140%) was observed in the control group while in the treated group Perf P and CVR slightly decreased (14 and 35%, respectively). CMRO2 decreased by 60% in the control group but remained within the normal range in the treated group. The fact that cvPO2 remained constantly below the initial value of 3.6 kPa in the control group and, on contrary, above this value in the group infused with @entity9 plus @entity8 indicates that the vCBF improvement leads to an increase in @entity0 supply and is involved in the keeping of the adequacy between flow and metabolism. Our results support the hypothesis that the @entity1 may play an important role in the acute prognosis of @entity2 . They clearly indicate that early cerebral resuscitation by infusion of @entity8 plus @entity9 , maintaining @entity0 availability and CBF above initial thresholds, should improve the long-term neurological outcome.

title: Curative effect of an XXXX - @entity9 combination in the postischemic syndrome following transient @entity6 in @entity3 .

answer: @entity8


abstract: Cerebral hemodynamic and metabolic changes, occurring during delayed hypoperfusion following transient @entity6 , and the influence of treatment with @entity8 plus @entity9 were studied in mongrel @entity3 . 10 min of transient @entity6 was induced by bilateral clamping of both carotid and vertebral arteries. After declamping, the mean time necessary until cerebral venous @entity7 (cvPO2) reached a value of 3.6 kPa, threshold for tissue @entity5 , was 80 min. At this time (T0), venous cerebral blood flow (vCBF) and cerebral perfusion pressure (Perf P) were below (60 and 20%, respectively) preischemic values, while cerebral vascular resistance (CVR) and @entity0 and @entity4 extraction rates increased despite a normal cerebral @entity0 consumption (CMRO2). At T0 ventilatory assistance without (control group) or with (treated group) intravenous infusion of @entity8 plus @entity9 was applied for 110 min. Between T0 and T110 min, 2 @entity3 died in the control group. During this period vCBF decreased by more than 60% in the control group while it slightly increased in the treated group. A strong decrease in Perf P (40%) and increase in CVR (140%) was observed in the control group while in the treated group Perf P and CVR slightly decreased (14 and 35%, respectively). CMRO2 decreased by 60% in the control group but remained within the normal range in the treated group. The fact that cvPO2 remained constantly below the initial value of 3.6 kPa in the control group and, on contrary, above this value in the group infused with @entity9 plus @entity8 indicates that the vCBF improvement leads to an increase in @entity0 supply and is involved in the keeping of the adequacy between flow and metabolism. Our results support the hypothesis that the @entity1 may play an important role in the acute prognosis of @entity2 . They clearly indicate that early cerebral resuscitation by infusion of @entity8 plus @entity9 , maintaining @entity0 availability and CBF above initial thresholds, should improve the long-term neurological outcome.

title: Curative effect of an @entity8 - @entity9 combination in the postischemic syndrome following transient @entity6 in XXXX .

answer: @entity3


abstract: We compared the response of ventricular muscle from adult and neonatal @entity0 to @entity3 . In adult muscle, @entity3 caused an initial rapid fall of developed @entity4 to 30 +/- 5% of control (mean +/- SEM, n = 6). However, @entity4 recovered slowly to a steady state that was 56 +/- 6% of control. In neonatal muscle, @entity3 caused a significantly smaller initial fall in @entity4 to 43 +/- 3% (n = 8, p less than 0.05), but the @entity4 then showed a subsequent slower fall to a steady state that was 29 +/- 4% of control, significantly less than in the adult (p less than 0.01). We have attempted to identify the mechanisms underlying these differences in response. In detergent-skinned myofibrils, reducing the pH from 7.0 to 6.5 caused a reduction in the pCa50 of 0.61 units in the adult muscle, but only 0.27 units in the neonatal ventricular muscle. Myofibrillar @entity1 sensitivity in neonatal ventricular muscle is thus less susceptible to the effects of acidic pH than that of adult muscle. Since intracellular pH decreases rapidly on application of increased external @entity2 , these results are consistent with the finding that, initially, developed @entity4 in neonatal muscles is less sensitive to the effects of @entity3 . Sodium dodecylsulfate gel electrophoresis of myofibrillar preparations from adult and neonatal @entity0 demonstrated differences in thin filament proteins, including troponin I, which may underlie the observed differences in @entity1 sensitivity. In adult @entity0 ventricular muscles, the slow recovery of @entity4 during @entity3 is associated with an increase in the amplitude of the @entity1 transients to 263 +/- 34% of control (n = 4).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effects of XXXX on ventricular muscle from adult and neonatal @entity0 .

answer: @entity3


abstract: We compared the response of ventricular muscle from adult and neonatal @entity0 to @entity3 . In adult muscle, @entity3 caused an initial rapid fall of developed @entity4 to 30 +/- 5% of control (mean +/- SEM, n = 6). However, @entity4 recovered slowly to a steady state that was 56 +/- 6% of control. In neonatal muscle, @entity3 caused a significantly smaller initial fall in @entity4 to 43 +/- 3% (n = 8, p less than 0.05), but the @entity4 then showed a subsequent slower fall to a steady state that was 29 +/- 4% of control, significantly less than in the adult (p less than 0.01). We have attempted to identify the mechanisms underlying these differences in response. In detergent-skinned myofibrils, reducing the pH from 7.0 to 6.5 caused a reduction in the pCa50 of 0.61 units in the adult muscle, but only 0.27 units in the neonatal ventricular muscle. Myofibrillar @entity1 sensitivity in neonatal ventricular muscle is thus less susceptible to the effects of acidic pH than that of adult muscle. Since intracellular pH decreases rapidly on application of increased external @entity2 , these results are consistent with the finding that, initially, developed @entity4 in neonatal muscles is less sensitive to the effects of @entity3 . Sodium dodecylsulfate gel electrophoresis of myofibrillar preparations from adult and neonatal @entity0 demonstrated differences in thin filament proteins, including troponin I, which may underlie the observed differences in @entity1 sensitivity. In adult @entity0 ventricular muscles, the slow recovery of @entity4 during @entity3 is associated with an increase in the amplitude of the @entity1 transients to 263 +/- 34% of control (n = 4).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effects of @entity3 on ventricular muscle from adult and neonatal XXXX .

answer: @entity0


abstract: BACKGROUND: The optimal timing of nephrology consultation in @entity0 with hospital-acquired @entity2 ( @entity2 ) is unknown. STUDY DESIGN: Prospective controlled nonrandomized intervention study. SETTING _ @entity0 : We screened daily serum @entity3 (SCr) levels of 4,296 @entity0 admitted to the St. Louis Veterans Affairs Medical Center between September and November 2008 (control group) and January to May 2009 (intervention group). 354 @entity0 (8.2%) met the definition of in-hospital @entity2 (SCr level increase of 0.3 mg/dL over 48 hours); 176 of whom met all inclusion criteria; 85 and 91 @entity0 were enrolled in the control (standard care) and intervention groups, respectively. INTERVENTION: Early renal service involvement (EARLI), defined as a 1-time nephrology consultation within 18 hours of the onset of @entity2 . OUTCOME: Primary outcome defined as 2.5-fold increase in SCr level from admission. MEASUREMENT: Daily SCr until discharge. RESULTS: The 2 groups had similar characteristics at baseline and at the time of @entity2 . The intervention was completed at a mean of 13.1    0.8 hours from the onset of @entity2 . Nephrology recommendations in the EARLI group included specific diagnostic, therapeutic, and preventative components. The primary outcome occurred in 12.9% of @entity0 in the control group compared with 3.3% of @entity0 in the EARLI group (P = 0.02). @entity0 in the EARLI group had a lower peak SCr level of 1.8    0.1 versus 2.1    0.2 mg/dL in controls (P = 0.01). LIMITATIONS: Single-center nonrandomized study of mostly US male veterans. CONCLUSIONS: Early nephrologist involvement in @entity0 with @entity2 may reduce the risk of a further @entity1 . A larger randomized trial is needed to confirm the findings.

title: Early nephrologist involvement in hospital-acquired XXXX : a pilot study.

answer: @entity2


abstract: UNASSIGNED: The recruitment of @entity3 / @entity4 exchange factors (GEFs) to specific subcellular sites dictates where they activate small G proteins for the regulation of various cellular processes. Cytohesins are a conserved family of plasma membrane GEFs for Arf small G proteins that regulate endocytosis. Analyses of @entity0 cytohesins have identified a number of recruitment mechanisms for these multi-domain proteins, but the conservation and developmental roles for these mechanisms are unclear. Here, we report how the pleckstrin homology (PH) domain of the @entity2 cytohesin Steppke affects its localization and activity at cleavage furrows of the early embryo. We found that the PH domain is necessary for Steppke furrow localization, and for it to regulate furrow structure. However, the PH domain was not sufficient for the localization. Next, we examined the role of conserved PH domain @entity5 residues that are required for @entity0 cytohesins to bind PIP3 or @entity4 -bound Arf G proteins. We confirmed that the Steppke PH domain preferentially binds PIP3 in vitro through a conserved mechanism. However, disruption of residues for PIP3 binding had no apparent effect on GFP-Steppke localization and effects. Rather, residues for binding to @entity4 -bound Arf G proteins made major contributions to this Steppke localization and activity. By analyzing GFP-tagged Arf and Arf-like small G proteins, we found that @entity6 -GFP, @entity7 -GFP and @entity8 -GFP, but not @entity9 -GFP, localized to furrows. However, analyses of embryos depleted of @entity6 , @entity7 or @entity8 revealed either @entity1 than occur in embryos depleted of Steppke, or no detectable @entity1 , possibly because of redundancies, and thus it was difficult to assess how individual Arf small G proteins affect Steppke. Nonetheless, our data show that the Steppke PH domain and its conserved residues for binding to @entity4 -bound Arf G proteins have substantial effects on Steppke localization and activity in early @entity2 embryos.

title: PH Domain-Arf G Protein Interactions Localize the Arf-GEF Steppke for Cleavage Furrow Regulation in XXXX .

answer: @entity2


abstract: OBJECTIVES: The study's objective was to evaluate with a standardized questionnaire the knowledge of healthcare workers (HCWs) regarding occupational vaccinations and their vaccination coverage. POPULATION AND METHODS: This cross-sectional survey was conducted in the department of @entity2 of a 1796 bed-teaching hospital in Dijon, France. RESULTS: Fifty-seven (93%) out of 61 HCPs completed the questionnaire. Vaccination against HVB was the most frequently mentioned vaccination (79%), followed by BCG (66%), and combine vaccine against @entity5 , @entity1 , and polio (DTP) (66 %). Influenza was the most often quoted among recommended vaccinations (70%), followed by measles (61%), @entity4 (39%), and @entity3 (14%). The number of correct answers was significantly correlated with age of @entity0 , being a physician, and having had courses on vaccination. Almost all HCPs were up to date for mandatory vaccinations. In 2009 to 2010, vaccination rates against seasonal flu and H1N1 flu reached 88%. Only 52% of HCPs knew about their @entity4 immunization and only a third of those born before 1980 had been tested for measles. CONCLUSIONS: HCPs knowledge of mandatory vaccinations is adequate but more limited for recommended vaccinations. Information on influenza vaccination has significantly improved its perception among HCPs resulting in a better adhesion to vaccination.

title: [Vaccination coverage of healthcare professionals in an XXXX department].

answer: @entity2


abstract: Animals with a targeted disruption of genes can be produced by @entity2 ( @entity2 ). However, difficulties in clonal selection of somatic cells with a targeted mutation often result in heterogeneous nuclear donor cells, including gene-targeted and non-targeted cells, and impose a risk of producing undesired wildtype cloned animals after @entity2 . In addition, the efficiency of cloning by @entity2 has remained extremely low. Most cloned embryos die in utero, and the few that develop to term show a high incidence of postnatal death and abnormalities. In the present study, resurrection of an @entity4 ( @entity4 ) gene-targeted miniature @entity3 by recloning using postmortem ear skin fibroblasts was attempted. Three cloned piglets were produced from the first round of @entity2 , including one stillborn and two who died immediately after birth due to @entity1 and @entity0 . Among the three piglets, two were confirmed to be @entity4 gene-targeted. Fibroblasts derived from postmortem ear skin biopsies were used as nuclear donor cells for the second round of @entity2 , and a piglet was produced. As expected, PCR and Southern analyses confirmed that the piglet produced from recloning was @entity4 gene-targeted. Currently, the piglet is fourteen months of age, and no overt health problems have been observed. Results from the present study demonstrate that loss of an invaluable animal, such as a gene-targeted miniature @entity3 , may be rescued by recloning, with assurance of the desired genetic modification.

title: Resurrection of an XXXX gene-targeted miniature @entity3 by recloning using postmortem ear skin fibroblasts.

answer: @entity4


abstract: Animals with a targeted disruption of genes can be produced by @entity2 ( @entity2 ). However, difficulties in clonal selection of somatic cells with a targeted mutation often result in heterogeneous nuclear donor cells, including gene-targeted and non-targeted cells, and impose a risk of producing undesired wildtype cloned animals after @entity2 . In addition, the efficiency of cloning by @entity2 has remained extremely low. Most cloned embryos die in utero, and the few that develop to term show a high incidence of postnatal death and abnormalities. In the present study, resurrection of an @entity4 ( @entity4 ) gene-targeted miniature @entity3 by recloning using postmortem ear skin fibroblasts was attempted. Three cloned piglets were produced from the first round of @entity2 , including one stillborn and two who died immediately after birth due to @entity1 and @entity0 . Among the three piglets, two were confirmed to be @entity4 gene-targeted. Fibroblasts derived from postmortem ear skin biopsies were used as nuclear donor cells for the second round of @entity2 , and a piglet was produced. As expected, PCR and Southern analyses confirmed that the piglet produced from recloning was @entity4 gene-targeted. Currently, the piglet is fourteen months of age, and no overt health problems have been observed. Results from the present study demonstrate that loss of an invaluable animal, such as a gene-targeted miniature @entity3 , may be rescued by recloning, with assurance of the desired genetic modification.

title: Resurrection of an @entity4 gene-targeted miniature XXXX by recloning using postmortem ear skin fibroblasts.

answer: @entity3


abstract: OBJECTIVE: To evaluate diagnostic image quality of high-pitch dual source comprehensive cardiothoracic CT protocol in @entity0 presenting with acute undifferentiated @entity2 . MATERIALS AND METHODS: Consecutive symptomatic subjects (n=51) with undifferentiated acute @entity2 underwent ECG-synchronized high-pitch dual-spiral chest CT angiography (Definition Flash, Siemens Medical Solutions, 2   100 kVp or 2   120 kV if BMI>30, collimation: 128   0.6mm, pitch: 3.2). Independent investigators determined the image quality of each cardiac and pulmonary vessel segment, measured contrast-to-noise-ratio (CNR), and determined radiation exposure. In addition, the prevalence of CT findings ( @entity3 ( @entity3 ), @entity4 ( @entity4 ) and significant @entity6 (>=  50%)) was determined. Univariate and multivariate analysis were performed to determine the subpopulation with highest diagnostic quality. RESULTS: Among 51 subjects (66% male, average age: 63    15.8), the prevalence of positive CT findings was moderate (overall: 11.7%). Overall, image quality of the pulmonary, aortic and coronary vasculature was good (1.26    0.43 and CNR: 2.52) with an average radiation dose of 3.82 @entity5 and 3.2% of segments rated non-evaluable. The image quality was lowest in the coronary arteries (p=0.02), depending on the heart rate (r=0.52, p<0.001). In subjects with a heart rate of  <= 65 bpm (n=30) subjective image quality and CNR of the coronary arteries were higher (1.6    0.5 vs. 2.1    0.5, p=0.03 and 1.21    0.3 vs. 1.02    0.3, p=0.05) with only 1.5% segments classified as non-evaluable. CONCLUSION: High-pitch dual-spiral comprehensive cardiothoracic CT provides low radiation exposure with excellent image quality at heart rates  <= 65 bpm. In subjects with higher heart rates, image quality of the aortic and @entity1 remains excellent, while the assessment of the coronary arteries degrades substantially.

title: Diagnostic image quality of a comprehensive high-pitch dual-spiral cardiothoracic CT protocol in @entity0 with undifferentiated acute XXXX .

answer: @entity2


abstract: OBJECTIVE: To evaluate diagnostic image quality of high-pitch dual source comprehensive cardiothoracic CT protocol in @entity0 presenting with acute undifferentiated @entity2 . MATERIALS AND METHODS: Consecutive symptomatic subjects (n=51) with undifferentiated acute @entity2 underwent ECG-synchronized high-pitch dual-spiral chest CT angiography (Definition Flash, Siemens Medical Solutions, 2   100 kVp or 2   120 kV if BMI>30, collimation: 128   0.6mm, pitch: 3.2). Independent investigators determined the image quality of each cardiac and pulmonary vessel segment, measured contrast-to-noise-ratio (CNR), and determined radiation exposure. In addition, the prevalence of CT findings ( @entity3 ( @entity3 ), @entity4 ( @entity4 ) and significant @entity6 (>=  50%)) was determined. Univariate and multivariate analysis were performed to determine the subpopulation with highest diagnostic quality. RESULTS: Among 51 subjects (66% male, average age: 63    15.8), the prevalence of positive CT findings was moderate (overall: 11.7%). Overall, image quality of the pulmonary, aortic and coronary vasculature was good (1.26    0.43 and CNR: 2.52) with an average radiation dose of 3.82 @entity5 and 3.2% of segments rated non-evaluable. The image quality was lowest in the coronary arteries (p=0.02), depending on the heart rate (r=0.52, p<0.001). In subjects with a heart rate of  <= 65 bpm (n=30) subjective image quality and CNR of the coronary arteries were higher (1.6    0.5 vs. 2.1    0.5, p=0.03 and 1.21    0.3 vs. 1.02    0.3, p=0.05) with only 1.5% segments classified as non-evaluable. CONCLUSION: High-pitch dual-spiral comprehensive cardiothoracic CT provides low radiation exposure with excellent image quality at heart rates  <= 65 bpm. In subjects with higher heart rates, image quality of the aortic and @entity1 remains excellent, while the assessment of the coronary arteries degrades substantially.

title: Diagnostic image quality of a comprehensive high-pitch dual-spiral cardiothoracic CT protocol in XXXX with undifferentiated acute @entity2 .

answer: @entity0


abstract: @entity4 constitute a significant disease burden and have a major impact on morbidity and mortality. This review discusses the relative merits of open surgery, whole brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS), which have been used alone and in combination with varying degrees of success for the treatment of newly diagnosed brain @entity1 . Treatment aims to provide disease control with a good quality of life, although prolonged survival may not always be achieved. Decision to treat is based on several prognostic factors including age, performance status and control of the primary @entity2 . The recently developed disease-specific graded prognostic assessment (DS-GPA) scales can aid in clinical decision making for individual @entity0 . Whole brain radiotherapy remains the mainstay of treatment and provides effective palliation. Omission of WBRT results in worse local and distant control, though not survival. @entity2 control can be achieved by either resection of stereotactic radiosurgery (SRS). In long-term survivors WBRT may cause @entity3 and SRS is being explored as an alternative method of disease control. Increasingly, quality of life and neuro-cognitive function are being used as end-points in clinical trials.

title: Management of cerebral XXXX : evidence-based approach for surgery, stereotactic radiosurgery and radiotherapy.

answer: @entity1


abstract: Thirty consecutive @entity0 from peninsular Malaysia with clinically definite @entity1 were studied; 80% were ethnic Chinese, with a female-male ratio of 5:1. The average age at onset was 29.7 years, with one relapse average every 1.9 years. Optic-spinal recurrence was the most common clinical pattern of the disease, accounting for 63.3% (19/30) of the cases. All the @entity0 had @entity3 sometime during the course of the illness. The mortality was high at 36.7% (11/30), with an average duration of symptoms of 7.6 years. There was characteristic severe residual @entity2 . At the time of the last examination, 12 @entity0 had bilateral @entity5 with @entity2 . Sixteen @entity0 were bedridden or confined to a wheelchair. The severe motor disability reflected the severe @entity3 . It was the main factor that accounted for the high mortality. The cerebral, cerebellar, and brain-stem involvements were, however, generally transient. None of the @entity0 ' had a family history of similar illness despite the average sibling size of six. There was no example of @entity4 . The clinical pattern was closest to those @entity0 who presented from Taiwan.

title: XXXX in Malaysia.

answer: @entity1


abstract: OBJECTIVE: Little is known about determinants of second-generation antipsychotic dosages during initial hospitalization of first-episode @entity1 . This study examined potential predictors of dosage of an atypical antipsychotic agent, @entity2 , at hospital discharge after initial evaluation and treatment of first-episode nonaffective @entity1 in 3 naturalistic, public-sector treatment settings. METHODS: The number of psychotropic agents prescribed and discharge antipsychotic dosage were abstracted from the medical record. Demographic and extensive clinical characteristics were assessed through a clinical research study conducted at the 3 sites. One-way analyses of variance, trend tests using specific linear combinations of estimates, and      tests assessed for associations between atypical antipsychotic dosage and 5 hypothesized predictors, as well as 12 exploratory variables. RESULTS: Among 155 hospitalized first-episode @entity0 , 121 (78.1%) were discharged on @entity2 , and subsequent analyses focused on that subset. The mean @entity2 dosage among those 121 @entity0 was 4.26 mg; 31 received 1 to 2 mg, 45 received 3 to 4 mg, 37 received 5 to 6 mg, and 8 received more than 6 mg. Analyses suggested that older age at hospitalization, the number of psychotropic agents prescribed, excited symptoms, and premorbid social functioning may be predictors of the discharge dosage. CONCLUSIONS: Although several factors emerged, in general, predictors of discharge dosages of second-generation agents, here exemplified by @entity2 , in real-world practice settings remain to be clarified. Given the importance of antipsychotic initiation during first hospitalization, future research should test an even broader array of potential predictors.

title: Predictors of the discharge dosage of an atypical antipsychotic agent among hospitalized, treatment-naive, first-episode XXXX @entity0 in naturalistic, public-sector settings.

answer: @entity1


abstract: OBJECTIVE: Little is known about determinants of second-generation antipsychotic dosages during initial hospitalization of first-episode @entity1 . This study examined potential predictors of dosage of an atypical antipsychotic agent, @entity2 , at hospital discharge after initial evaluation and treatment of first-episode nonaffective @entity1 in 3 naturalistic, public-sector treatment settings. METHODS: The number of psychotropic agents prescribed and discharge antipsychotic dosage were abstracted from the medical record. Demographic and extensive clinical characteristics were assessed through a clinical research study conducted at the 3 sites. One-way analyses of variance, trend tests using specific linear combinations of estimates, and      tests assessed for associations between atypical antipsychotic dosage and 5 hypothesized predictors, as well as 12 exploratory variables. RESULTS: Among 155 hospitalized first-episode @entity0 , 121 (78.1%) were discharged on @entity2 , and subsequent analyses focused on that subset. The mean @entity2 dosage among those 121 @entity0 was 4.26 mg; 31 received 1 to 2 mg, 45 received 3 to 4 mg, 37 received 5 to 6 mg, and 8 received more than 6 mg. Analyses suggested that older age at hospitalization, the number of psychotropic agents prescribed, excited symptoms, and premorbid social functioning may be predictors of the discharge dosage. CONCLUSIONS: Although several factors emerged, in general, predictors of discharge dosages of second-generation agents, here exemplified by @entity2 , in real-world practice settings remain to be clarified. Given the importance of antipsychotic initiation during first hospitalization, future research should test an even broader array of potential predictors.

title: Predictors of the discharge dosage of an atypical antipsychotic agent among hospitalized, treatment-naive, first-episode @entity1 XXXX in naturalistic, public-sector settings.

answer: @entity0


abstract: To improve the performance of exercise stress testing in the diagnosis of @entity3 while minimizing risks of serious complications, we evaluated an impulse response of ST changes, which is a transient ST response resulting from a hypothetical, strenuous-impulselike exercise, without actually imposing the strenuous load. To obtain the impulse response, subjects walked intermittently according to a computer-generated random binary sequence on a treadmill for 20 minutes (with a constant speed of 1.7 mph and a slope of 10%). We used Fourier transform for beat-to-beat changes in ST level and the binary sequence of exercise. We then determined the transfer function by taking the ratio of Fourier transformed ST level to exercise over the frequency range of 0.5 through 5.0 cycles/min. Converting the transfer function to the time domain yielded the impulse response of ST change. The subjects consisted of 49 @entity0 (60 +/- 9 years) with @entity3 , 13 @entity0 with atypical @entity2 (56 +/- 9 years), and 30 healthy, male volunteers (23 +/- 7 years). In 82 subjects (89%), the ST impulse response showed an initial @entity1 followed by a smooth, gradual restoration toward the preexercise ST level (type I response). The average duration of the initial @entity1 was 8 +/- 3 seconds in the healthy volunteers, whereas it was significantly prolonged to 23 +/- 14 seconds in @entity3 (p less than 0.05). The @entity1 in @entity0 with atypical @entity2 was not significantly different from that in the healthy volunteers.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Random exercise stress test in diagnosing XXXX .

answer: @entity3


abstract: OBJECTIVE: to describe acute @entity8 as the initial manifestation of @entity6 . BACKGROUND: bilateral, predominantly motor, cervical @entity2 , the "dangling arm syndrome," has not been reported as a complication of acute Lyme infection. METHODS: retrospective series of 5 @entity0 from 2 tertiary neuromuscular centers. RESULTS: there were 4 @entity0 and 1 @entity0 with an average age of 69 years. One recalled a tick bite, and preceding constitutional symptoms included @entity1 (2) and @entity4 , @entity7 , and fatigue in 1 @entity0 each. Proximal arm @entity5 and @entity9 developed within 3 weeks from onset; @entity3 was bilateral in 3 @entity0 and unilateral in 2 @entity0 , and was described as severe throbbing. Arm @entity5 was bilateral at onset in 3 @entity0 , and right sided in 2 @entity0 followed by spread to the left arm within days. All the @entity0 had @entity5 in the deltoid and biceps that was 3/5 or less (Medical Research Council scale), with variable @entity5 of the triceps and wrist extensors; 1 @entity0 had a flail right arm and moderate (4/5) @entity5 of the proximal left arm muscles. Light touch was normal in the regions of @entity5 , and 1 @entity0 had mildly reduced pin sensation over the forearm. Serum IgM Lyme titers were elevated in all the @entity0 and were detected in the cerebrospinal fluid in 4 tested @entity0 . The cerebrospinal fluid protein ranged between 135 and 176 mg/dL with lymphocytic pleocytosis (range, 42 to 270 cells). Electrodiagnostic studies showed normal median and ulnar motor potentials with asymmetrically reduced sensory amplitudes in the median (4), ulnar (3), and radial, and lateral antebrachial cutaneous potentials in 1 @entity0 each. Two @entity0 had acute denervation in the cervical or proximal arm muscles. There was full recovery after antibiotic therapy in 4 @entity0 and considerable improvement in 1 @entity0 after 2 months. CONCLUSION: acute @entity8 is a rare manifestation of acute Lyme infection and responds promptly to antibiotic therapy.

title: Acute XXXX due to @entity6 .

answer: @entity8


abstract: OBJECTIVE: to describe acute @entity8 as the initial manifestation of @entity6 . BACKGROUND: bilateral, predominantly motor, cervical @entity2 , the "dangling arm syndrome," has not been reported as a complication of acute Lyme infection. METHODS: retrospective series of 5 @entity0 from 2 tertiary neuromuscular centers. RESULTS: there were 4 @entity0 and 1 @entity0 with an average age of 69 years. One recalled a tick bite, and preceding constitutional symptoms included @entity1 (2) and @entity4 , @entity7 , and fatigue in 1 @entity0 each. Proximal arm @entity5 and @entity9 developed within 3 weeks from onset; @entity3 was bilateral in 3 @entity0 and unilateral in 2 @entity0 , and was described as severe throbbing. Arm @entity5 was bilateral at onset in 3 @entity0 , and right sided in 2 @entity0 followed by spread to the left arm within days. All the @entity0 had @entity5 in the deltoid and biceps that was 3/5 or less (Medical Research Council scale), with variable @entity5 of the triceps and wrist extensors; 1 @entity0 had a flail right arm and moderate (4/5) @entity5 of the proximal left arm muscles. Light touch was normal in the regions of @entity5 , and 1 @entity0 had mildly reduced pin sensation over the forearm. Serum IgM Lyme titers were elevated in all the @entity0 and were detected in the cerebrospinal fluid in 4 tested @entity0 . The cerebrospinal fluid protein ranged between 135 and 176 mg/dL with lymphocytic pleocytosis (range, 42 to 270 cells). Electrodiagnostic studies showed normal median and ulnar motor potentials with asymmetrically reduced sensory amplitudes in the median (4), ulnar (3), and radial, and lateral antebrachial cutaneous potentials in 1 @entity0 each. Two @entity0 had acute denervation in the cervical or proximal arm muscles. There was full recovery after antibiotic therapy in 4 @entity0 and considerable improvement in 1 @entity0 after 2 months. CONCLUSION: acute @entity8 is a rare manifestation of acute Lyme infection and responds promptly to antibiotic therapy.

title: Acute @entity8 due to XXXX .

answer: @entity6


abstract: STUDY DESIGN: Prospective analysis of 600 extreme lateral interbody fusion (XLIF) approach procedures for intraoperative and perioperative complications. OBJECTIVE: To delineate and describe complications in a large, prospective series of minimally invasive lateral lumbar fusion procedures (XLIF). SUMMARY OF BACKGROUND DATA: While some small series of lateral lumbar fusion have discussed complications, no results from large studies have been reported. METHODS: A total of 600 @entity0 were treated with a lateral approach to fusion (XLIF) for degenerative spinal conditions. Data were collected prospectively on all @entity0 and analyzed for demographic, diagnostic, and hospitalization information to identify operative and early @entity4 . Documented complication types and rates in this large series were compared with smaller prior reports on lateral approach fusions, as well as other minimally invasive (mini-anterior lumbar interbody fusion and minimally invasive surgical [MIS] transforaminal lumbar interbody fusion) and more traditional fusion approaches (posterior intertransverse fusion, anterior lumbar interbody fusion, posterior lumbar interbody fusion, transforaminal lumbar interbody fusion). RESULTS: Seven hundred forty-one levels were treated, 80.8% single level, 15.0% 2 level, 4.0% 3 level, 0.2% 4 level; 59.3%, including the L4 to L5 levels. A total of 99.2% included supplemental internal fixation; 83.2% included pedicle screw fixation (predominantly unilateral). Hemoglobin change from pre- to postoperation averaged 1.38. Hospital stay averaged 1.21 days. The overall incidence of perioperative complications (intraoperation and out to 6 weeks postoperation) was 6.2%: 9 (1.5%) in-hospital surgery-related events, 17 (2.8%) in-hospital medical events, 6 (1.0%) out-of-hospital surgery-related events, and 5 (0.8%) out-of-hospital medical events. There were no wound @entity5 , no @entity6 , no intraoperative @entity3 , and 4 (0.7%) transient @entity2 . Eleven events (1.8%) resulted in additional procedures/reoperation. CONCLUSIONS: Compared with traditional open approaches, the MIS lateral approach to fusion by using the XLIF technique resulted in a lower incidence of @entity1 , and transfusion as well as markedly shorter hospitalization. Complications in MIS XLIF compare favorably with those from other MIS fusion procedures; duration of hospitalization is shorter than with any previously reported technique.

title: Intraoperative and early XXXX in extreme lateral interbody fusion: an analysis of 600 cases.

answer: @entity4


abstract: STUDY DESIGN: A cross sectional multicenter study in six outpatient @entity5 ( @entity5 ) in the Netherlands. OBJECTIVE: This study aims to confirm or refute the finding that a strong relationship exists between @entity4 and self-reported disability in @entity0 with nonspecific @entity3 ( @entity3 ) by analyzing this relationship in @entity0 with @entity3 admitted for treatment in six @entity5 . SUMMARY OF BACKGROUND DATA: A strong relationship between @entity4 and self-reported disability in @entity0 with @entity3 is suggested. However, in former research weak relationships were found in two of the @entity5 participating in this study. METHODS: Total study sample consisted of 293 @entity0 (30-66 per RC) with @entity3 , admitted for outpatient multidisciplinary rehabilitation in one of the six participating @entity5 . Psychosocial distress was measured with the Symptom Checklist-90-Revised (SCL-90-R), self-reported disability with the @entity2 ( @entity2 ). Pearson correlation coefficients between @entity4 and self-reported disability were calculated. Multivariate regression analysis was performed to analyze the relationship between SCL-90-R and VAS @entity1 (independent variables) and @entity2 (dependent variable) for the total group and for each RC separately. A multivariate regression analysis was performed to analyze the relationship between all baseline characteristics and @entity2 in the total group. RESULTS: Correlation coefficient between the SCL-90-R and @entity2 was r = 0.38 for the total sample, indicating a significant (P < 0.05), but weak relationship. For the six individual @entity5 , correlation coefficients ranged between r = 0.22 and 0.67 (three of the six correlation coefficients were significant). The explained variance (r) of the regression models (SCL-90 and @entity1 intensity as predictors of @entity2 ) was 29% for the total sample, and varied between the @entity5 from 17% to 52%. Results of the multivariate regression analysis of all baseline characteristics of the total group revealed that the model explained 36% of the total variance observed in @entity2 score. Overall, the contributions of @entity4 to the models were smaller and more variable compared with @entity1 intensity. CONCLUSION: The overall relationship between @entity4 and self reported disability was weak, and differences between @entity5 were considerable. This indicates that the relationship between @entity4 and disability in @entity0 with @entity3 is not uniform.

title: Differences in the relationship between @entity4 and self-reported disability in @entity0 with XXXX in @entity1 rehabilitation centers in the Netherlands.

answer: @entity3


abstract: STUDY DESIGN: A cross sectional multicenter study in six outpatient @entity5 ( @entity5 ) in the Netherlands. OBJECTIVE: This study aims to confirm or refute the finding that a strong relationship exists between @entity4 and self-reported disability in @entity0 with nonspecific @entity3 ( @entity3 ) by analyzing this relationship in @entity0 with @entity3 admitted for treatment in six @entity5 . SUMMARY OF BACKGROUND DATA: A strong relationship between @entity4 and self-reported disability in @entity0 with @entity3 is suggested. However, in former research weak relationships were found in two of the @entity5 participating in this study. METHODS: Total study sample consisted of 293 @entity0 (30-66 per RC) with @entity3 , admitted for outpatient multidisciplinary rehabilitation in one of the six participating @entity5 . Psychosocial distress was measured with the Symptom Checklist-90-Revised (SCL-90-R), self-reported disability with the @entity2 ( @entity2 ). Pearson correlation coefficients between @entity4 and self-reported disability were calculated. Multivariate regression analysis was performed to analyze the relationship between SCL-90-R and VAS @entity1 (independent variables) and @entity2 (dependent variable) for the total group and for each RC separately. A multivariate regression analysis was performed to analyze the relationship between all baseline characteristics and @entity2 in the total group. RESULTS: Correlation coefficient between the SCL-90-R and @entity2 was r = 0.38 for the total sample, indicating a significant (P < 0.05), but weak relationship. For the six individual @entity5 , correlation coefficients ranged between r = 0.22 and 0.67 (three of the six correlation coefficients were significant). The explained variance (r) of the regression models (SCL-90 and @entity1 intensity as predictors of @entity2 ) was 29% for the total sample, and varied between the @entity5 from 17% to 52%. Results of the multivariate regression analysis of all baseline characteristics of the total group revealed that the model explained 36% of the total variance observed in @entity2 score. Overall, the contributions of @entity4 to the models were smaller and more variable compared with @entity1 intensity. CONCLUSION: The overall relationship between @entity4 and self reported disability was weak, and differences between @entity5 were considerable. This indicates that the relationship between @entity4 and disability in @entity0 with @entity3 is not uniform.

title: Differences in the relationship between @entity4 and self-reported disability in @entity0 with @entity3 in XXXX rehabilitation centers in the Netherlands.

answer: @entity1


abstract: STUDY DESIGN: A cross sectional multicenter study in six outpatient @entity5 ( @entity5 ) in the Netherlands. OBJECTIVE: This study aims to confirm or refute the finding that a strong relationship exists between @entity4 and self-reported disability in @entity0 with nonspecific @entity3 ( @entity3 ) by analyzing this relationship in @entity0 with @entity3 admitted for treatment in six @entity5 . SUMMARY OF BACKGROUND DATA: A strong relationship between @entity4 and self-reported disability in @entity0 with @entity3 is suggested. However, in former research weak relationships were found in two of the @entity5 participating in this study. METHODS: Total study sample consisted of 293 @entity0 (30-66 per RC) with @entity3 , admitted for outpatient multidisciplinary rehabilitation in one of the six participating @entity5 . Psychosocial distress was measured with the Symptom Checklist-90-Revised (SCL-90-R), self-reported disability with the @entity2 ( @entity2 ). Pearson correlation coefficients between @entity4 and self-reported disability were calculated. Multivariate regression analysis was performed to analyze the relationship between SCL-90-R and VAS @entity1 (independent variables) and @entity2 (dependent variable) for the total group and for each RC separately. A multivariate regression analysis was performed to analyze the relationship between all baseline characteristics and @entity2 in the total group. RESULTS: Correlation coefficient between the SCL-90-R and @entity2 was r = 0.38 for the total sample, indicating a significant (P < 0.05), but weak relationship. For the six individual @entity5 , correlation coefficients ranged between r = 0.22 and 0.67 (three of the six correlation coefficients were significant). The explained variance (r) of the regression models (SCL-90 and @entity1 intensity as predictors of @entity2 ) was 29% for the total sample, and varied between the @entity5 from 17% to 52%. Results of the multivariate regression analysis of all baseline characteristics of the total group revealed that the model explained 36% of the total variance observed in @entity2 score. Overall, the contributions of @entity4 to the models were smaller and more variable compared with @entity1 intensity. CONCLUSION: The overall relationship between @entity4 and self reported disability was weak, and differences between @entity5 were considerable. This indicates that the relationship between @entity4 and disability in @entity0 with @entity3 is not uniform.

title: Differences in the relationship between XXXX and self-reported disability in @entity0 with @entity3 in @entity1 rehabilitation centers in the Netherlands.

answer: @entity4


abstract: STUDY DESIGN: A cross sectional multicenter study in six outpatient @entity5 ( @entity5 ) in the Netherlands. OBJECTIVE: This study aims to confirm or refute the finding that a strong relationship exists between @entity4 and self-reported disability in @entity0 with nonspecific @entity3 ( @entity3 ) by analyzing this relationship in @entity0 with @entity3 admitted for treatment in six @entity5 . SUMMARY OF BACKGROUND DATA: A strong relationship between @entity4 and self-reported disability in @entity0 with @entity3 is suggested. However, in former research weak relationships were found in two of the @entity5 participating in this study. METHODS: Total study sample consisted of 293 @entity0 (30-66 per RC) with @entity3 , admitted for outpatient multidisciplinary rehabilitation in one of the six participating @entity5 . Psychosocial distress was measured with the Symptom Checklist-90-Revised (SCL-90-R), self-reported disability with the @entity2 ( @entity2 ). Pearson correlation coefficients between @entity4 and self-reported disability were calculated. Multivariate regression analysis was performed to analyze the relationship between SCL-90-R and VAS @entity1 (independent variables) and @entity2 (dependent variable) for the total group and for each RC separately. A multivariate regression analysis was performed to analyze the relationship between all baseline characteristics and @entity2 in the total group. RESULTS: Correlation coefficient between the SCL-90-R and @entity2 was r = 0.38 for the total sample, indicating a significant (P < 0.05), but weak relationship. For the six individual @entity5 , correlation coefficients ranged between r = 0.22 and 0.67 (three of the six correlation coefficients were significant). The explained variance (r) of the regression models (SCL-90 and @entity1 intensity as predictors of @entity2 ) was 29% for the total sample, and varied between the @entity5 from 17% to 52%. Results of the multivariate regression analysis of all baseline characteristics of the total group revealed that the model explained 36% of the total variance observed in @entity2 score. Overall, the contributions of @entity4 to the models were smaller and more variable compared with @entity1 intensity. CONCLUSION: The overall relationship between @entity4 and self reported disability was weak, and differences between @entity5 were considerable. This indicates that the relationship between @entity4 and disability in @entity0 with @entity3 is not uniform.

title: Differences in the relationship between @entity4 and self-reported disability in XXXX with @entity3 in @entity1 rehabilitation centers in the Netherlands.

answer: @entity0


abstract: @entity7 ( @entity8 ) was produced and used by various industries and in consumer products. Because of its persistence, it is ubiquitous in air, water, soil, wildlife, and @entity0 . Although the adverse effects of @entity8 on male fertility have been reported, the underlying mechanisms have not yet been elucidated. Here, for the first time, the effects of @entity8 on testicular signaling, such as gonadotropin, growth hormone, insulin-like growth factor, and inhibins/activins were shown to be directly related to male subfertility. Sexually mature 8-wk-old @entity3 male @entity1 were administered by gavages in @entity4 oil daily with 0, 1, 5, or 10 mg/kg @entity8 for 7, 14, or 21 days. Serum concentrations of @entity2 and epididymal sperm counts were significantly lower in the @entity1 after 21 days of the exposure to the highest dose compared with the controls. The expression levels of @entity6 were considerably reduced on Day 21 in @entity1 exposed daily to 10 or 5 mg/kg @entity8 . The transcript levels of the subunits of the testicular factors (i.e., inhibins and activins), @entity9 , @entity5 , and @entity12 , were significantly lower on Day 21 of daily exposure to 10, 5, or 1 mg/kg @entity8 . The mRNA expression levels of steroidogenic enzymes (i.e., StAR, @entity10 , @entity11 , 3beta-HSD, and @entity13 ) were notably reduced. Therefore, @entity8 -elicited subfertility in male @entity1 is manifested as progressive deterioration of testicular signaling.

title: Testicular signaling is the potential target of XXXX -mediated subfertility in male @entity1 .

answer: @entity7


abstract: @entity7 ( @entity8 ) was produced and used by various industries and in consumer products. Because of its persistence, it is ubiquitous in air, water, soil, wildlife, and @entity0 . Although the adverse effects of @entity8 on male fertility have been reported, the underlying mechanisms have not yet been elucidated. Here, for the first time, the effects of @entity8 on testicular signaling, such as gonadotropin, growth hormone, insulin-like growth factor, and inhibins/activins were shown to be directly related to male subfertility. Sexually mature 8-wk-old @entity3 male @entity1 were administered by gavages in @entity4 oil daily with 0, 1, 5, or 10 mg/kg @entity8 for 7, 14, or 21 days. Serum concentrations of @entity2 and epididymal sperm counts were significantly lower in the @entity1 after 21 days of the exposure to the highest dose compared with the controls. The expression levels of @entity6 were considerably reduced on Day 21 in @entity1 exposed daily to 10 or 5 mg/kg @entity8 . The transcript levels of the subunits of the testicular factors (i.e., inhibins and activins), @entity9 , @entity5 , and @entity12 , were significantly lower on Day 21 of daily exposure to 10, 5, or 1 mg/kg @entity8 . The mRNA expression levels of steroidogenic enzymes (i.e., StAR, @entity10 , @entity11 , 3beta-HSD, and @entity13 ) were notably reduced. Therefore, @entity8 -elicited subfertility in male @entity1 is manifested as progressive deterioration of testicular signaling.

title: Testicular signaling is the potential target of @entity7 -mediated subfertility in male XXXX .

answer: @entity1


abstract: OBJECTIVE: To evaluate the perioperative outcome and long-term survival of @entity0 who underwent surgical resection for recurrent @entity1 within a multimodal approach in the era of @entity2 ( @entity2 ). BACKGROUND: Introduction of @entity2 has reduced local recurrence and improved oncological outcome of @entity0 with @entity1 . Local recurrence after @entity2 still occurs in 2% to 8% of @entity0 and presents a challenge to surgical and medical oncologists. However, there has been very limited data on the perioperative and long-term outcome of @entity0 who are operated for local recurrence in the era of @entity2 . METHODS: A total of 107 @entity0 who were identified from a prospective @entity1 database underwent surgical exploration for recurrent @entity1 after previous @entity2 between October 2001 and April 2009. Risk factors of perioperative morbidity were analyzed using a multivariate logistic regression model. Independent predictors of disease-specific survival were identified by a Cox proportional hazards regression model, as were those of local recurrence and disease recurrence at any site. RESULTS: Surgical resection was performed in 92 @entity0 and negative resection margins were achieved in 54 (58.7%) of these. Recurrent disease was located intraluminally and extraluminally in 35 (38.0%) @entity0 and 57 (62.0%) @entity0 , respectively. A total of 19 (20.6%) @entity0 had metastatic extrapelvic disease at the time of surgery. Perioperative surgical morbidity and in-hospital mortality accounted for 42.4% and 3.3%, respectively. On multivariate analysis, partial sacrectomy was associated with surgical morbidity (P = 0.004). Three- and 5-year disease-specific survival rates were 61% and 47%. Three-year survival rate of @entity0 with extrapelvic disease who underwent R0 resection was 42%. On multivariate analysis, surgical morbidity (P = 0.001), presence of extrapelvic disease (P = 0.006), and noncurative (R1; R2) resection (P < 0.0001) were identified as independent adverse predictors of disease-specific survival, whereas a transabdominal resection (as opposed to an abdominoperineal resection/pelvic exenteration) was associated with a more favorable prognosis (P = 0.04). CONCLUSIONS: Surgical resection of local recurrence from @entity1 in the era @entity2 can be carried out with acceptable morbidity and curative resection rates. Curative resection remains the major prognostic factor and may enable long-term survival even in @entity0 with extrapelvic disease.

title: Surgery for locally recurrent @entity1 in the era of XXXX : is there still a chance for cure?

answer: @entity2


abstract: OBJECTIVE: To evaluate the perioperative outcome and long-term survival of @entity0 who underwent surgical resection for recurrent @entity1 within a multimodal approach in the era of @entity2 ( @entity2 ). BACKGROUND: Introduction of @entity2 has reduced local recurrence and improved oncological outcome of @entity0 with @entity1 . Local recurrence after @entity2 still occurs in 2% to 8% of @entity0 and presents a challenge to surgical and medical oncologists. However, there has been very limited data on the perioperative and long-term outcome of @entity0 who are operated for local recurrence in the era of @entity2 . METHODS: A total of 107 @entity0 who were identified from a prospective @entity1 database underwent surgical exploration for recurrent @entity1 after previous @entity2 between October 2001 and April 2009. Risk factors of perioperative morbidity were analyzed using a multivariate logistic regression model. Independent predictors of disease-specific survival were identified by a Cox proportional hazards regression model, as were those of local recurrence and disease recurrence at any site. RESULTS: Surgical resection was performed in 92 @entity0 and negative resection margins were achieved in 54 (58.7%) of these. Recurrent disease was located intraluminally and extraluminally in 35 (38.0%) @entity0 and 57 (62.0%) @entity0 , respectively. A total of 19 (20.6%) @entity0 had metastatic extrapelvic disease at the time of surgery. Perioperative surgical morbidity and in-hospital mortality accounted for 42.4% and 3.3%, respectively. On multivariate analysis, partial sacrectomy was associated with surgical morbidity (P = 0.004). Three- and 5-year disease-specific survival rates were 61% and 47%. Three-year survival rate of @entity0 with extrapelvic disease who underwent R0 resection was 42%. On multivariate analysis, surgical morbidity (P = 0.001), presence of extrapelvic disease (P = 0.006), and noncurative (R1; R2) resection (P < 0.0001) were identified as independent adverse predictors of disease-specific survival, whereas a transabdominal resection (as opposed to an abdominoperineal resection/pelvic exenteration) was associated with a more favorable prognosis (P = 0.04). CONCLUSIONS: Surgical resection of local recurrence from @entity1 in the era @entity2 can be carried out with acceptable morbidity and curative resection rates. Curative resection remains the major prognostic factor and may enable long-term survival even in @entity0 with extrapelvic disease.

title: Surgery for locally recurrent XXXX in the era of @entity2 : is there still a chance for cure?

answer: @entity1


abstract: Background. There are a variety of described noninvasive optical detection techniques for evaluation of @entity0 . Contact endoscopy is a promising method of in vivo microscopic examination whereby a rigid telescope is placed on a previously dye-stained mucosa allowing evaluation of the superficial cell layers of the epithelium. This technique produces real-time, magnified images of cellular architecture of surface mucosa comparable to histology without the need for biopsy. In this review, we will briefly summarize the efficacy of CE in the detection of precancerous and @entity1 and its potential as a novel technique in early diagnosis, monitoring, and preoperative assessment of @entity2 of the head and neck. Methods. PUBMED, MEDLINE, and COCHRANE search revealed five prospective articles on contact endoscopy for the diagnosis of @entity2 in the head and neck. Results. The literature search yielded five prospective studies examining contact endoscopy for the diagnosis of benign versus malignant @entity0 . These reported a sensitivity and specificity of 77-100%, specificity of 66-100% and an accuracy of 72-92%. Conclusion. Contact endoscopy is a promising optical technology that may be a useful adjunct in the evaluation and diagnosis of benign and malignant @entity0 . Future prospective randomized double-blind studies of this detection method are required.

title: Contact endoscopy as a novel technique in the detection and diagnosis of XXXX in the head and neck: a brief review.

answer: @entity2


abstract: Voltage-dependent anion channel (VDAC) is the main protein in mitochondria-mediated apoptosis, and the modulation of VDAC may be induced by the excessive release of extracellular @entity2 . This study examined the role of @entity2 release on VDAC-mediated apoptosis in an eleven vessel occlusion model in @entity0 . Male @entity0 (250-350 g) were used for the 11 vessel occlusion @entity1 model, which were induced for a 10-min transient occlusion. During the @entity1 and initial reperfusion episode, the real-time monitoring of the extracellular @entity2 concentration was measured using an amperometric microdialysis biosensor and the cerebral blood flow (CBF) was monitored by laser-Doppler flowmetry. To confirm neuronal apoptosis, the brains were removed 72 h after @entity1 to detect the neuron-specific nuclear protein and pro-apoptotic proteins (cleaved caspase-3, VDAC, @entity4 and @entity3 ). The changes in the mitochondrial morphology were measured by atomic force microscopy. A decrease in the % of CBF was observed, and an increase in @entity2 release was detected after the onset of @entity1 , which continued to increase during the @entity1 period. A significantly higher level of @entity2 release was observed in the @entity1 group. The increased @entity2 levels in the @entity1 group resulted in the activation of VDAC and pro-apoptotic proteins in the hippocampus with morphological alterations to the mitochondria. This study suggests that an increase in @entity2 release promotes VDAC-mediated apoptosis in an 11 vessel occlusion @entity1 model.

title: The role of XXXX release on voltage-dependent anion channels (VDAC)-mediated apoptosis in an eleven vessel occlusion model in @entity0 .

answer: @entity2


abstract: Voltage-dependent anion channel (VDAC) is the main protein in mitochondria-mediated apoptosis, and the modulation of VDAC may be induced by the excessive release of extracellular @entity2 . This study examined the role of @entity2 release on VDAC-mediated apoptosis in an eleven vessel occlusion model in @entity0 . Male @entity0 (250-350 g) were used for the 11 vessel occlusion @entity1 model, which were induced for a 10-min transient occlusion. During the @entity1 and initial reperfusion episode, the real-time monitoring of the extracellular @entity2 concentration was measured using an amperometric microdialysis biosensor and the cerebral blood flow (CBF) was monitored by laser-Doppler flowmetry. To confirm neuronal apoptosis, the brains were removed 72 h after @entity1 to detect the neuron-specific nuclear protein and pro-apoptotic proteins (cleaved caspase-3, VDAC, @entity4 and @entity3 ). The changes in the mitochondrial morphology were measured by atomic force microscopy. A decrease in the % of CBF was observed, and an increase in @entity2 release was detected after the onset of @entity1 , which continued to increase during the @entity1 period. A significantly higher level of @entity2 release was observed in the @entity1 group. The increased @entity2 levels in the @entity1 group resulted in the activation of VDAC and pro-apoptotic proteins in the hippocampus with morphological alterations to the mitochondria. This study suggests that an increase in @entity2 release promotes VDAC-mediated apoptosis in an 11 vessel occlusion @entity1 model.

title: The role of @entity2 release on voltage-dependent anion channels (VDAC)-mediated apoptosis in an eleven vessel occlusion model in XXXX .

answer: @entity0


abstract: We studied the ultrastructure and degradative activity of lysosomes in @entity0 livers after somatic @entity3 due to @entity1 secondary to shock and/or @entity5 . The livers were obtained at autopsy after varying postmortem intervals. Liver ultrastructure was studied in intact liver, in hepatocyte suspension obtained by collagenase perfusion of the liver, and in cultured hepatocytes. Lysosomal protein degradation was measured in a case 24 hours after hepatocyte isolation. By standard ultrastructural criteria, all the livers demonstrated typical reversible manifestations of cell injury. Most hepatocytes demonstrated varying degrees of irreversible cell injury. The ultrastructural alterations were less severe in the isolated hepatocytes in suspensions, and further improvement in morphologic appearance occurred in the cultured monolayers. The most striking alteration in the liver lysosomes was the increase in the numbers of lipofuscin granules (a type of residual body) compared with control liver. The hepatocyte lysosomes constituted an average 3.1% of cytoplasmic volume. There was no correlation between the volume density of lysosomes and either the duration of @entity4 , clinical course, or @entity0 's age. There was no increase in the number of autophagic vacuoles or of secondary lysosomes in postmortem liver. Autophagic vacuoles were more frequently seen in isolated and cultured hepatocytes. Cultured hepatocytes isolated within one hour of clinical @entity3 and tested 24 hours later degraded cell proteins at a rate of 1.7% per hour. Protein degradation was stimulated by a physiologic signal ( @entity7 , 1 mmol/L) and was inhibited by microtubule poison ( @entity6 ). We conclude that (1) viable hepatocytes can be isolated even after prolonged postmortem intervals (range, 30 minutes to seven hours), (2) @entity2 and shock cause an expansion of hepatocyte lysosomes due to accumulation of lipofuscin, and (3) autophagy is blocked by @entity4 and resumes in the recovery phase from @entity2 in hepatocyte suspensions and in culture.

title: Response of @entity0 hepatocyte lysosomes to XXXX .

answer: @entity4


abstract: We studied the ultrastructure and degradative activity of lysosomes in @entity0 livers after somatic @entity3 due to @entity1 secondary to shock and/or @entity5 . The livers were obtained at autopsy after varying postmortem intervals. Liver ultrastructure was studied in intact liver, in hepatocyte suspension obtained by collagenase perfusion of the liver, and in cultured hepatocytes. Lysosomal protein degradation was measured in a case 24 hours after hepatocyte isolation. By standard ultrastructural criteria, all the livers demonstrated typical reversible manifestations of cell injury. Most hepatocytes demonstrated varying degrees of irreversible cell injury. The ultrastructural alterations were less severe in the isolated hepatocytes in suspensions, and further improvement in morphologic appearance occurred in the cultured monolayers. The most striking alteration in the liver lysosomes was the increase in the numbers of lipofuscin granules (a type of residual body) compared with control liver. The hepatocyte lysosomes constituted an average 3.1% of cytoplasmic volume. There was no correlation between the volume density of lysosomes and either the duration of @entity4 , clinical course, or @entity0 's age. There was no increase in the number of autophagic vacuoles or of secondary lysosomes in postmortem liver. Autophagic vacuoles were more frequently seen in isolated and cultured hepatocytes. Cultured hepatocytes isolated within one hour of clinical @entity3 and tested 24 hours later degraded cell proteins at a rate of 1.7% per hour. Protein degradation was stimulated by a physiologic signal ( @entity7 , 1 mmol/L) and was inhibited by microtubule poison ( @entity6 ). We conclude that (1) viable hepatocytes can be isolated even after prolonged postmortem intervals (range, 30 minutes to seven hours), (2) @entity2 and shock cause an expansion of hepatocyte lysosomes due to accumulation of lipofuscin, and (3) autophagy is blocked by @entity4 and resumes in the recovery phase from @entity2 in hepatocyte suspensions and in culture.

title: Response of XXXX hepatocyte lysosomes to @entity4 .

answer: @entity0


abstract: OBJECTIVES: To evaluate the comparative effectiveness of antiviral drugs in adults with chronic @entity5 monoinfection for evidence-based decision-making. METHODS: A systematic review of @entity4 ( @entity4 ) published in English. Results after interferon and nucleos(t)ides analog therapies were synthesized with random-effects meta-analyses and number needed to treat (NNT). RESULTS: Despite sustained improvements in selected biomarkers, no one drug regimen improved all intermediate outcomes. In 16 underpowered @entity4 , drug treatments did not reduce mortality, @entity2 , or @entity1 . Sustained @entity3 DNA clearance was achieved in one @entity0 when two were treated with @entity10 (NNT from 1 RCT=2 95%CI 1;2) or @entity6 (NNT from 2 @entity4 =2 95%CI 2;4), 13 with @entity8 (NNT from 1 RCT=13 95%CI 7;1000), and 11 with peginterferon alpha-2a vs. @entity8 (NNT from 1 RCT=11 95%CI 7;25). Sustained @entity7 seroconversion was achieved in one @entity0 when eight were treated with @entity6 (NNT from 2 @entity4 =8 95%CI 5;33) or 10--with peginterferon alpha-2b vs. @entity6 (NNT from 1 RCT=10 95%CI 5;1000). Greater benefits and safety after @entity9 vs. @entity8 or pegylated @entity6 vs. @entity6 require future investigation of clinical outcomes. Adverse events were common and more frequent after interferon. Treatment utilization for adverse effects is unknown. CONCLUSIONS: Individual clinical decisions should rely on comparative effectiveness and absolute rates of intermediate outcomes and adverse events. Future research should clarify the relationship of intermediate and clinical outcomes and cost-effectiveness of drugs for evidence-based policy and clinical decisions.

title: Systematic review of the literature on comparative effectiveness of antiviral treatments for chronic XXXX .

answer: @entity5


abstract: UNASSIGNED: @entity1 is one of the most common @entity2 characterized by large and invalidating mood swings. Several projects focus on the development of decision support systems that monitor and advise @entity0 , as well as clinicians. Voice monitoring and speech signal analysis can be exploited to reach this goal. In this study, an Android application was designed for analyzing running speech using a smartphone device. The application can record audio samples and estimate speech fundamental frequency, F0, and its changes. F0-related features are estimated locally on the smartphone, with some advantages with respect to remote processing approaches in terms of privacy protection and reduced upload costs. The raw features can be sent to a central server and further processed. The quality of the audio recordings, algorithm reliability and performance of the overall system were evaluated in terms of voiced segment detection and features estimation. The results demonstrate that mean F0 from each voiced segment can be reliably estimated, thus describing prosodic features across the speech sample. Instead, features related to F0 variability within each voiced segment performed poorly. A case study performed on a @entity1 @entity0 is presented.

title: Smartphone Application for the Analysis of Prosodic Features in Running Speech with a Focus on XXXX : System Performance Evaluation and Case Study.

answer: @entity1


abstract: UNASSIGNED: Primary @entity4 are a group of rare @entity5 , derived from mature T lymphocytes and initially developing only in the skin. The most common @entity3 representing this group are @entity6 fungoides and @entity9 . @entity6 fungoides is an @entity1 with a chronic course and characteristic evolution of the @entity2 from erythematous patches, through plaques to @entity0 . @entity9 is characterized by an aggressive course and a triad of symptoms ( @entity8 , generalized @entity7 , and the presence of atypical cells in the skin, lymph nodes and peripheral blood). The etiopathogenesis of @entity3 is not fully understood, but a few studies on angiogenesis and lymphangiogenesis in these @entity0 indicate a significant role in their development and progression. Angiogenesis is a process of formation of new blood vessels from existing ones. Lymphangiogenesis is a similar process concerning lymphatic vasculature. Development of new vessels is a complex process composed of several successive stages: migration, proliferation, and differentiation of endothelial cells, extracellular matrix degradation and formation and stabilization of new vessels, regulated by growth factors, cytokines and other proteins. Both phenomena are essential in the development and progression of solid @entity0 and @entity5 . Therapeutic strategies involving the inhibition of @entity0 angiogenesis and lymphangiogenesis are a promising new direction of studies in antitumor therapy, requiring further experiments.

title: Angiogenesis and lymphangiogenesis in primary XXXX .

answer: @entity4


abstract: UNASSIGNED: Objectives To assess the perceived pitch and @entity1 of popular music by cochlear implant (CI) users. Methods Eleven experienced post-lingually deafened adult CI users rated the pitch, @entity1 , and clarity of a popular song with 10 frequency allocation settings, including the default. The alternative settings all had logarithmic frequency spacing and frequency shifts of less than one octave compared with the default map. For maps which were perceived as having incorrect pitch, @entity0 adjusted the pitch of the song in real time using a slider, in order to normalize it, and the amount of adjustment was recorded. Results The default map was rated as having close to correct pitch. Naturalness rating was negatively correlated with basal shift from a baseline logarithmic map, which was the same as the default map for basal electrodes (R(2)  =  0.77). Ratings of the clarity of the lyrics were adversely affected by basal shift. The majority of @entity0 were able to rate and adjust pitch appropriately. The frequency shift in the map was highly correlated with @entity0 ' adjustments of the pitch slider (R(2)  =  0.94), but the adjustments were less than expected for the majority of @entity0 . Discussion The pitch ratings for the default allocation suggest that @entity0 have acclimatized to their processors' frequency allocations. Adjustment of the pitch of the song was possible for the majority and suggested that all but one @entity0 was experiencing frequency compression. Expansion of the frequency allocation might help to alleviate this. Conclusion Adjustment of the pitch of a popular song could be helpful for tuning CIs.

title: Perception of the pitch and XXXX of popular music by cochlear implant users.

answer: @entity1


abstract: Importance: @entity0 who undergo open airway reconstruction procedures are likely to experience some degree of @entity1 and delayed @entity3 . Objective: To review the duration of @entity1 and outcomes in a group of adult @entity0 . Design, Setting, and @entity0 : Retrospective review of the medical records of adult @entity0 undergoing laryngotracheoplasty, posterior cricoid split laryngoplasty, tracheal resection, and cricotracheal resection in a tertiary hospital between July 2009 and September 2014. Exposures: Laryngotracheoplasty, posterior cricoid split laryngoplasty, tracheal resection, and cricotracheal resection. Main Outcomes and Measures: Demographic characteristics, etiology of airway stenosis, surgical procedure, stent type, and duration of @entity2 symptoms. Results: Thirty-eight @entity0 (14 @entity0 , 24 @entity0 ; mean [SD; range] age, 48 [14.4; 20-80] years) fitting the inclusion criteria were identified. Twenty-four (63%) @entity0 had laryngotracheal stenosis secondary to prolonged intubation, with 3 (8%), 5 (13%), and 6 (16%) cases being due to autoimmune, idiopathic, or other etiology, respectively. Twenty-five (66%) @entity0 underwent tracheal or cricotracheal resection, and 13 (34%) underwent laryngotracheoplasty or posterior cricoid split laryngoplasty. Of the 17 @entity0 with stents placed, 6 (35%) @entity0 had a suprastomal stent sewn at the top with a @entity5 suture using a horizontal mattress technique, 6 (35%) @entity0 had a suprastomal stent capped with an extended Silastic thoracic T-tube segment, and 5 (29%) @entity0 had either @entity4 or hood bronchial stent. Eight of 17 @entity0 used a nasogastric feeding tube while the stent was in place (up to 5 weeks). All @entity0 returned to their preoperative diet. The mean (SD) duration of @entity2 symptoms in all @entity0 (both those without a stent and following stent removal) was 8 (27.2) days (median, 1.5 days). The mean (SD) duration of @entity2 symptoms in @entity0 who did not have a stent placed was 4.8 (5.3) days (median, 4 days). Conclusions and Relevance: In this study of adults who underwent open airway reconstruction, all returned to their preoperative diet, but those without stents had a shorter duration of @entity2 symptoms than those with stents. Approximately half as many @entity0 with a stent had a prolonged course with @entity2 symptoms compared with those without a stent.

title: XXXX Following Airway Reconstruction in Adults.

answer: @entity2


abstract: BACKGROUND: We evaluated national compliance to selected quality indicators from the Dutch multidisciplinary evidence-based guideline on @entity3 and identified areas for improvement. METHODS: Compliance to 3 selected quality indicators from the guideline was evaluated before and after implementation of the guideline in 2011: 1) adjuvant chemotherapy after @entity1 resection for @entity3 , 2) discussion of the @entity0 within a multidisciplinary team (MDT) meeting and 3) a maximum 3-week interval between final MDT meeting and start of treatment. RESULTS: In total 5086 @entity0 with @entity3 were included. In 2010, 2522 @entity0 were included and in 2012, 2564 @entity0 . 1) Use of adjuvant chemotherapy following resection for @entity3 increased significantly from 45% (120 out of 268) in 2010 to 54% (182 out of 336) in 2012 which was mainly caused by an increase in @entity0 aged <75 years. 2) In 2012, 64% (896 of 1396) of @entity0 suspected of a @entity3 was discussed within a MDT meeting which was higher in @entity0 aged <75 years and @entity0 starting treatment with curative intent. 3) In 2012, the recommended 3 weeks between final MDT meeting and start of treatment was met in 39% (141 of 363) of @entity0 which was not influenced by @entity0 and @entity1 characteristics. CONCLUSION: Compliance to three selected quality indicators in @entity2 care was low in 2012. Areas for improvement were identified. Future compliance will be investigated through structured audit and feedback from the Dutch @entity2 Audit.

title: National compliance to an evidence-based multidisciplinary guideline on XXXX .

answer: @entity3


abstract: PURPOSE: @entity3 are extremely uncommon in adolescents. This study was undertaken to assess the clinical and radiological characteristics and clarify the choice of therapeutic strategies of @entity3 in adolescents with age range from 15 to 18 years. METHODS: From our dedicated aneurysmal databank between October 1985 and July 2008, we reviewed 16 consecutive adolescents who had 20 @entity3 . RESULTS: Ten @entity0 and six @entity0 (male/female ratio = 1.67:1; mean age 16.78      1.18 years) were included in the present study. @entity3 in adolescents constituted 0.91% of all @entity3 . It was found that 25% of the lesions were in the posterior circulation, while 75% of the lesions were in the anterior circulation, and 25% developed on the middle cerebral artery (MCA). Half of the @entity0 presented with @entity5 and others mainly presented with mass effect such as @entity1 , @entity7 , and @entity8 . Eight cases underwent endovascular treatment: including GDC therapy in five @entity0 , parental @entity2 in two @entity0 , and cover stent implantation in one @entity0 with @entity9 of the cavernous segment of the left internal carotid artery. Four @entity0 received microsurgical therapy: aneurismal neck clipping for two @entity0 and extracranial-intracranial (EC-IC) bypass and trapping of complex @entity4 in MCA for the other two @entity0 . Four @entity0 did not receive microsurgical or endovascular therapy, including a @entity0 whose @entity4 spontaneously thrombosed preoperatively and a @entity0 who died before operation because of rerupture of @entity4 . Two @entity0 did not undergo therapy owing to the high operative risk. All of the @entity0 who received therapy had favorable outcome (GOS 4 or 5) at discharge and at follow-up. CONCLUSIONS: @entity3 in adolescents differ from those in adults in many ways including the following: male predominance; high incidence of large or giant, traumatic, dissecting, and fusiform @entity4 ; high incidence of @entity4 in the posterior circulation; high incidence of spontaneous @entity6 ; better Hunt-Hess grade at presentation; and better therapeutic outcome. Both microsurgical approaches and endovascular treatment were effective. For some giant, @entity3 , parent @entity2 or EC-IC bypass is the best treatment choice.

title: XXXX in adolescents.

answer: @entity3


abstract: The urinary excretion of a @entity2 -containing oligosaccharide, Glc alpha[1-6Glc alpha[1-4Glc alpha[1-4Glc, (Glc4) has been measured in various physiological and pathological conditions. The Glc4 content of 24 h samples from the same individual was relatively constant, whereas 2 h samples showed up to 4-fold variations in Glc4 concentration. This variation is associated mainly with @entity3 after meals. A @entity5 -rich diet, starvation or a protein-rich diet, and intense physical activity all affected the urinary excretion of Glc4. Both oral and intravenous administration of glycogen in a @entity6 resulted in @entity3 . When Glc4 itself was injected intravenously in small amounts renal clearance was rapid and complete. In contrast, injection of a larger amount resulted in incomplete (approximately 10%) renal clearance, probably due to uptake and metabolism of the oligosaccharide. In @entity0 with glycogen storage diseases, certain @entity1 , and @entity4 , 24 h urinary Glc4 excretion exceeded the normal range. The diagnostic implications of these observations deserve evaluation. The results presented suggest a need for standardization of nutritional status and physical activity when monitoring urinary Glc4 excretion for diagnostic purposes.

title: Urinary excretion of a XXXX -containing tetrasaccharide. A parameter for increased degradation of glycogen.

answer: @entity2


abstract: An epidemiological study was conducted to assess the rates of condemnation and the diagnoses made on condemned broiler @entity3 carcasses in a federally-inspected abattoir. The first objective was to determine the predictive value of a positive test: the proportion of birds that were truly unfit for @entity0 consumption among condemned carcasses. The second objective was to assess the degree of agreement between diagnoses made in the abattoir and diagnoses determined by a detailed gross postmortem examination on the same condemned carcasses. A two-stage convenience sampling technique was used to obtain the birds needed. Fifteen lots of birds were selected and within each of these, approximately 45 condemned carcasses were selected for a total of 680. All the diagnoses made on these birds at the abattoir were recorded and the carcasses individually identified. The sampled carcasses were transported to the Ontario Veterinary College where a panel of three federal veterinarians independently judged whether the birds were fit for @entity0 consumption. In addition, a detailed gross postmortem examination was conducted on each carcass. An overall predictive value of a positive test of approximately 70% was found. The degree of agreement among members of the panel of examiners was also tested. The overall agreement was good (Kappa = 0.62 between examiners 1 and 2 and 0.51 between examiners 1 and 3). However, carcasses condemned for specific conditions at the abattoir, namely valgus @entity1 , mutilation, @entity4 and @entity2 showed no agreement beyond chance, while other carcasses condemned for conditions such as cyanosis and @entity5 showed poor agreement concerning their disposition for at least one pair of examiners.(ABSTRACT TRUNCATED AT 250 WORDS)

title: An assessment of condemnations of broiler XXXX carcasses.

answer: @entity3


abstract: INTRODUCTION: @entity2 ( @entity2 ) is a systemic @entity6 which can affect the neurological system. @entity2 ( @entity2 ) is not well described in @entity0 . OBJECTIVE: Our study aimed to analyse the clinical patterns of paediatric @entity2 and to describe their repercussions on @entity0 's schooling. METHODS: We performed a retrospective chart review of 12 @entity2 @entity0 and a phone interview of @entity0 and their physicians to investigate their last physical and schooling status. RESULTS: In 40 @entity2 @entity0 reviewed, 12 (sex ratio 8M/4F) had neurological involvement. The mean age of onset was 11 years. In 4 cases, @entity1 were the initial presentation. In other cases, @entity2 occurred within a mean time of 10 months after @entity2 was diagnosed. @entity5 were frequent (5/12) as compared to recurrent @entity9 (2/12), rhombencephalitis (2/12), transverse @entity8 (1/12), @entity7 (1/12) or @entity3 disturbances (1/12). 9 @entity0 had sequelae and 8 had difficulties in learning. 6 stopped at middle school level. For the other @entity0 , an arrangement of the teaching environment was needed due to @entity4 . CONCLUSION: @entity1 is frequent in @entity2 @entity0 and its consequences could be severe. Timely accommodations are required to facilitate their ability to follow the normal curriculum.

title: XXXX in paediatric Beh  et's disease.

answer: @entity1


abstract: In the last ten years, 17 @entity0 with @entity3 refractory to standard ventilator therapy have been treated with extracorporeal membrane oxygenation (ECMO) at the Toronto General Hospital. One @entity0 was treated with ECMO twice. Four perfusions were veno-arterial, the remainder veno-venous. Perfusions ranged from 1 1/2 to 19 days, with a mean of six days. Ten @entity0 died during treatment or soon after it was discontinued. Eight @entity0 improved enough to allow resumption of standard ventilation, and four @entity0 recovered sufficiently to have normal arterial blood gas levels on room air. Three are long-term survivors. Multiple surgical procedures have been performed successfully during use of ECMO including lung lavage, open lung biopsy and three lung transplants. Major complications include @entity2 and @entity1 . The technique involves a substantial commitment of time and personnel but remains a tenable option for presumed reversible life-threatening @entity3 .

title: Ten-year experience with extracorporeal membrane oxygenation for severe XXXX .

answer: @entity3


abstract: The first knockout of a @entity4 receptor was published more than 10 years ago and since then most of the @entity4 receptors have been genetically inactivated in @entity1 . Reviewing the @entity3 -related behavior of individual receptor knockout lines, it is apparent that genetic inactivation of some receptors, including the 5-HT2A and 5-HT3 receptors, reproduced the phenotype elicited by the acute pharmacological blockade of the receptor. This indicates that signaling through some @entity4 receptors is directly involved in the regulation of @entity3 states. In other cases, however, the genetic inactivation and pharmacological blockade of the receptor resulted in different and sometimes opposing behaviors. For example, the genetic inactivation of the @entity4 transporter results in increased @entity3 whereas chronic pharmacological blockade of the @entity4 transporter by SSRIs leads to reduced @entity3 . @entity1 null for the @entity6 show increased @entity3 , while selective pharmacological inhibitors of the receptor do not have a measurable effect on @entity3 in adult @entity1 . These are interesting findings because the genetic inactivation of the receptor could be similar to inherited conditions characterized by a loss of function mutation of the receptor/transporter. Indeed, @entity4 transporter knockout in @entity1 may reproduce the s polymorphism in @entity0 . Also, certain individuals have a reduced expression of the @entity6 that, if present from early life, is similar to the null mutation of the receptor in @entity1 . Therefore, the @entity6 and @entity4 transporter knock-out @entity1 strains may @entity2 models that can be used to understand how a @entity5 leads to an @entity3 -like phenotype.

title: Use of @entity1 with Targeted Genetic Inactivation in the Serotonergic System for the Study of XXXX

answer: @entity3