abstract: OBJECTIVES: To identify risk factors of 30-day readmissions due to ambulatory care-sensitive conditions (ACSCs) for @entity1 Medicare home healthcare beneficiaries in order to improve transition from hospital-based care to home healthcare. STUDY DESIGN: We analyzed @entity1 Medicare beneficiaries who received home healthcare within 14 days of hospital discharges in 2009. The unit of analysis is the home health episode for post acute care. METHODS: The conceptual framework was guided by Andersen's Behavioral Model of Health Services. Data sources included: Medicare Beneficiary Summary File, Medicare Provider Analysis Review, Outcome Assessment Information Set, Home Health Agency Research Identifiable File, Hospital Readmissions Reduction Program Supplemental Data File, Provider of Services File, and Area Health Resources File. The dependent variable was time to first 30-day ACSC-related readmission. Proportional hazards regression was used for the statistical analyses. RESULTS: The 30-day ACSC-related readmission rate was approximately 6% in our study sample, costing the Medicare program about  62 million. Predictors of readmissions due to ACSCs within 30 days of hospital discharge were: being aged 75 to 84 years, being an African American, requiring assistance in medication management, and having 1 or more of the following clinical conditions: congestive @entity6 , @entity8 , @entity7 , @entity3 , @entity5 , fluid and electrolyte diseases, @entity4 and/or @entity2 , and pressure or stasis ulcer. @entity0 with @entity7 or @entity3 had a 40% higher risk of 30-day ACSC-related readmissions than their counterparts. CONCLUSIONS: Knowing the risk factors identified above, hospital providers can improve care planning and transition of care to the home healthcare providers.

title: Improving @entity1 XXXX transition to home healthcare: leading risk factors for 30-day readmission.

answer: @entity0


abstract: The objective of this study was to develop a high-frequency imaging platform for evaluating @entity2 in @entity0 based on shear-wave elasticity imaging (SWEI). Although SWEI has been used to diagnose @entity2 clinically, it is performed at relatively low frequencies (<20 MHz). For preclinical ultrasound imaging in small animals, a high-frequency (>30 MHz) single-element transducer with mechanical scanning is often used. In this study we developed a new SWEI system based on a 40-MHz single-element transducer for imaging and a separate 20-MHz excitation transducer for producing the radiation force and the associated shear waves. @entity2 was induced in ten C57BL/6 (B6) @entity0 using @entity3 ; the other ten @entity0 served as the control group. Synchronizing the excitation beam (i.e., the beam from the excitation transducer) and the detection beam sequence (i.e., the beam from the imaging transducer) allows this mechanicalscanning setup to analyze the shear-wave dispersion relation. The liver viscoelastic properties were determined in vivo by measuring the shear-wave dispersion curve followed by fitting to the Voigt model. The @entity0 were then killed and the @entity1 stage was evaluated (from F0 to F4) based on the METAVIR score. The measured mean values of liver elasticity and viscosity, respectively, ranged from 1.06 to 1.89 kPa and from 1.29 to 1.75 Pa   s for normal F0 and @entity1 stages of F3 and F4. The Spearman coefficients for the correlations between the measured elasticity and viscosity at various @entity1 stages as assessed by the METAVIR score were 0.73 (p < 0.001) and 0.634 (p = 0.0013), respectively. We also found that the collagen content in the liver was linearly correlated with the measured elasticity (r(2) = 0.54, p < 0.001) and less strongly with the viscosity (r2 = 0.26, p = 0.022). Finally, the diagnosis performance of high-frequency SWEI was evaluated using multivariate receiver operating characteristic curve (ROC) analysis. The areas under the multivariate ROC curve for diagnosing @entity1 stages of F >=  3, F = 4, F0 vs. F3, F0 vs. F4, and F3 vs. F4 were 0.9, 0.98, 0.83, 1.0, and 0.96, respectively. Compared with traditional ROC analysis, an improved diagnosis performance was found for diagnosing @entity1 stages of F >=  3 and F0 vs. F3. These results demonstrate that the developed high-frequency SWEI platform can yield quantitative viscoelastic properties for diagnosing various @entity1 stages in @entity0 . It is a promising tool for studying the progression of @entity2 in preclinical animal models both noninvasively and quantitatively.

title: Shear-wave elasticity imaging of a XXXX @entity0 model using high-frequency ultrasound.

answer: @entity2


abstract: The objective of this study was to develop a high-frequency imaging platform for evaluating @entity2 in @entity0 based on shear-wave elasticity imaging (SWEI). Although SWEI has been used to diagnose @entity2 clinically, it is performed at relatively low frequencies (<20 MHz). For preclinical ultrasound imaging in small animals, a high-frequency (>30 MHz) single-element transducer with mechanical scanning is often used. In this study we developed a new SWEI system based on a 40-MHz single-element transducer for imaging and a separate 20-MHz excitation transducer for producing the radiation force and the associated shear waves. @entity2 was induced in ten C57BL/6 (B6) @entity0 using @entity3 ; the other ten @entity0 served as the control group. Synchronizing the excitation beam (i.e., the beam from the excitation transducer) and the detection beam sequence (i.e., the beam from the imaging transducer) allows this mechanicalscanning setup to analyze the shear-wave dispersion relation. The liver viscoelastic properties were determined in vivo by measuring the shear-wave dispersion curve followed by fitting to the Voigt model. The @entity0 were then killed and the @entity1 stage was evaluated (from F0 to F4) based on the METAVIR score. The measured mean values of liver elasticity and viscosity, respectively, ranged from 1.06 to 1.89 kPa and from 1.29 to 1.75 Pa   s for normal F0 and @entity1 stages of F3 and F4. The Spearman coefficients for the correlations between the measured elasticity and viscosity at various @entity1 stages as assessed by the METAVIR score were 0.73 (p < 0.001) and 0.634 (p = 0.0013), respectively. We also found that the collagen content in the liver was linearly correlated with the measured elasticity (r(2) = 0.54, p < 0.001) and less strongly with the viscosity (r2 = 0.26, p = 0.022). Finally, the diagnosis performance of high-frequency SWEI was evaluated using multivariate receiver operating characteristic curve (ROC) analysis. The areas under the multivariate ROC curve for diagnosing @entity1 stages of F >=  3, F = 4, F0 vs. F3, F0 vs. F4, and F3 vs. F4 were 0.9, 0.98, 0.83, 1.0, and 0.96, respectively. Compared with traditional ROC analysis, an improved diagnosis performance was found for diagnosing @entity1 stages of F >=  3 and F0 vs. F3. These results demonstrate that the developed high-frequency SWEI platform can yield quantitative viscoelastic properties for diagnosing various @entity1 stages in @entity0 . It is a promising tool for studying the progression of @entity2 in preclinical animal models both noninvasively and quantitatively.

title: Shear-wave elasticity imaging of a @entity2 XXXX model using high-frequency ultrasound.

answer: @entity0


abstract: As one of the three West African countries highly affected by the 2014-2015 @entity1 , Liberia reported approximately 10,000 cases. The @entity1 in Liberia was marked by intense urban transmission, multiple community outbreaks with source cases occurring in @entity0 coming from the urban areas, and outbreaks in health care facilities (HCFs). This report, based on data from routine case investigations and contact tracing, describes efforts to stop the last known chain of Ebola transmission in Liberia. The index @entity0 became ill on December 29, 2014, and the last of 21 associated cases was in a @entity0 admitted into an Ebola treatment unit (ETU) on February 18, 2015. The chain of transmission was stopped because of early detection of new cases; identification, monitoring, and support of contacts in acceptable settings; effective triage within the health care system; and rapid isolation of symptomatic contacts. In addition, a "sector" approach, which divided Montserrado County into geographic units, facilitated the ability of response teams to rapidly respond to community needs. In the final stages of the outbreak, intensive coordination among partners and engagement of community leaders were needed to stop transmission in densely populated Montserrado County. A companion report describes the efforts to enhance infection prevention and control efforts in HCFs. After February 19, no additional clusters of Ebola cases have been detected in Liberia. On May 9, the World Health Organization declared the end of the Ebola outbreak in Liberia.

title: Controlling the last known XXXX - Liberia, January-February 2015.

answer: @entity1


abstract: OBJECTIVE: To analyze the safety and efficacy of surgical removal of recurrent or regrowing @entity2 by endoscopic endonasal transsphenoidal approach. METHODS: The clinical data were retrospectively reviewed for 28 @entity0 undergoing endoscopic endonasal transsphenoidal surgery for recurrent or regrowing @entity2 between April 2010 and December 2013. There were 9 males and 19 females with a mean age of 44. 2 (11 - 73) years. The maximal @entity1 diameter ranged from 2. 1 to 6.9 cm. The Knosp grades were 1 -2 (n = 11), 3 (n =8) and 4 (n =9). Fifteen @entity1 were endocrinically functional and the remainder endocrinically nonfunctional. All operations were performed with an assistance of intraoperative neuronavigation. Neuro-ophthalmological, neuroimaging and endocrinological results were followed up postoperatively. And surgical outcomes and risk factors were analyzed for incomplete @entity1 resection in previous operations. RESULTS: The mean follow-up period was 19. 1 (3 - 45) months. Gross total resection(n = 18, 64. 3%), subtotal resection(n = 6, 21. 4%) and partial resection(n = 4, 14. 3%) were achieved. Postoperatively, visual acuity improved in 11 @entity0 (73. 3%) and 6 @entity0 (40. 0%) showed endocrine remission. Qne @entity0 had short-term postoperative leakage of cerebrospinal fluid (CSF). CONCLUSION: Endoscopic endonasal transsphenoidal surgery is both safe and effective for recurrent or regrowing @entity2 .

title: [Efficacy analysis of endoscopic endonasal transsphenoidal surgery for recurrent or regrowing XXXX ].

answer: @entity2


abstract: OBJECTIVE: To investigate the topological properties of the functional brain network in unilateral @entity2 @entity0 . METHODS: In this study, we acquired resting-state BOLD- fMRI data from 19 right-sided SNHL @entity0 and 31 healthy controls with normal hearing and constructed their whole brain functional networks. Two-sample two-tailed t-tests were performed to investigate group differences in topological parameters between the USNHL @entity0 and the controls. Partial correlation analysis was conducted to determine the relationships between the network metrics and USNHL-related variables. RESULTS: Both USNHL @entity0 and controls exhibited @entity3 in their brain functional networks within the range 0. 1 - 0. 2 of sparsity. Compared to the controls, USNHL @entity0 showed significant increase in characteristic path length and normalized characteristic path length, but significant decrease in global efficiency. Clustering coefficient, local efficiency and normalized clustering coefficient demonstrated no significant difference. Furthermore, USNHL @entity0 exhibited no significant association between the altered network metrics and the duration of USNHL or the severity of @entity1 . CONCLUSION: Our results indicated the altered topological properties of whole brain functional networks in USNHL @entity0 , which may help us to understand pathophysiologic mechanism of USNHL @entity0 .

title: [Aberrant topological properties of whole-brain functional network in chronic right-sided XXXX : a resting-state functional MRI study].

answer: @entity2


abstract: BACKGROUND: @entity9 decreases airway neutrophilia and can prevent chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx). It also can be used to treat @entity10 , as it decreases the submucosal infiltrating @entity8 positive lymphocytes. Some @entity0 , while receiving @entity9 , (re)develop increased airway neutrophilia, which we hypothesize to result in worse outcome and to be regulated by an @entity8 -independent mechanism. METHODS: LTx recipients, transplanted between 2001 and 2012, were investigated and categorized in a study group of @entity0 with @entity1 (BAL) neutrophilia (>= 15%) and a matched control group with low BAL neutrophilia (<15%), both groups while already being on @entity9 treatment. CLAD-free and overall survival were compared between groups. Cell differentials and 33 proteins in BAL were analyzed to identify underlying mechanisms. RESULTS: The study group (n=72) demonstrated a significantly lower CLAD-free (p=0.015) and overall survival (p=0.041) compared to the control group (n=37). Absolute BAL neutrophils and eosinophils were increased in the study group, which was paralleled by elevated inflammatory cytokines ( @entity5 / @entity4 , @entity7 and @entity2 ) and chemokines ( @entity3 / @entity3 , @entity6 / @entity6 , @entity11 / @entity11 , @entity12 / @entity12 , @entity13 /eotaxin) concentrations compared to the control group (all p<0.05). CONCLUSION: @entity0 with elevated airway neutrophilia despite @entity9 , experience worse CLAD-free and overall survival. In these @entity0 , @entity5 might play a central role giving rise to neutrophils, eosinophils, macrophages and B-cells. This provides an opportunity to further investigate the modulation of this pathway.

title: BAL neutrophilia in XXXX -treated lung transplant recipients: Clinical significance.

answer: @entity9


abstract: UNASSIGNED: @entity2 is an important tool for preventing @entity1 in inpatient settings but definitions vary and there is no clear practice guideline. We aimed to identify how clinical staff define and conceptualize de-escalation, which de-escalation interventions they would use in aggressive scenarios, and their beliefs about the efficacy of de-escalation interventions. A questionnaire survey (n   =   72) was conducted using open and closed questions; additionally, clinical vignettes describing conflict events were presented for @entity0 to describe their likely clinical response. Qualitative data were subject to thematic analysis. The major themes that de-escalation encompassed were communication, tactics, de-escalator qualities, assessment and risk, getting help, and containment measures. Different types of @entity1 were met with different interventions. Half of @entity0 erroneously identified p.r.n. medication as a de-escalation intervention, and 15% wrongly stated that seclusion, restraint, and emergency i.m. medication could be de-escalation interventions. Those interventions seen as most effective were the most commonly used. Clinical staff's views about de-escalation, and their de-escalation practice, may differ from optimal practice. Use of containment measures and p.r.n. medication where de-escalation is more appropriate could have a negative impact; work is needed to promote understanding and use of appropriate de-escalation interventions based on a clear guideline.

title: XXXX : A survey of clinical staff in a secure mental health inpatient service.

answer: @entity2


abstract: Up-front fecal diversion can palliate emergent symptoms related to locally advanced @entity1 (LARC) allowing @entity0 to receive neoadjuvant chemoradiation therapy (nCRT). We analyzed outcomes of pretreatment-diverted LARC @entity0 relative to nondiverted @entity0 to define the impact of this management strategy. We retrospectively collected data on 103 LARC @entity0 treated with nCRT and surgery. Medical records were reviewed for @entity0 characteristics, staging, treatment plan, and outcomes. Thirteen LARC @entity0 underwent pretreatment diversion for urgent symptoms and 90 LARC @entity0 proceeded directly to nCRT. In all, 50 per cent of diverted @entity0 presented with T4 @entity1 compared with 14 per cent in the nondiverted @entity0 (P = 0.003). Diverted @entity0 experienced a delay in time-to-treatment initiation of 12 days, although this difference was not statistically significant. Similar rates of chemoradiation and surgical @entity2 were observed. Even though diverted @entity0 demonstrated less pathologic response to nCRT compared with nondiverted @entity0 (P = 0.04), there was no significant difference in overall survival. In conclusion, our study demonstrates the effectiveness of up-front fecal diversion at managing emergent obstructive symptoms related to advanced @entity1 without additional complications, allowing @entity0 to proceed with nCRT followed by radical surgery.

title: The impact of surgical diversion before neoadjuvant therapy for XXXX .

answer: @entity1


abstract: OBJECTIVE: To report our prospective comparison of clinical efficacy between multimodular flexible ureteroscope, PolyScope, and conventional flexible ureteroscope, both combined with holmium laser lithotripsy in managing @entity1  <3  cm in diameter. @entity0 AND METHODS: Between February 2011 and July 2014, a total of 360 adult @entity0 with @entity1 were randomized in a single tertiary-care center trial. For 180 @entity0 in each arm, flexible ureteroscopy and holmium laser lithotripsy were done with either PolyScope or Olympus URF @entity2 as control. The primary end points were single-session stone fragmentation rate and stone-free rate. The secondary end points comprised operation time, complication rate, and hospital stay. RESULTS: Demographic and preoperative parameters were comparable between 2 groups. For stones of different locations and sizes, single-session stone fragmentation rate of PolyScope was similar to that of URF @entity2 . However, for lower calyceal stones, URF @entity2 was significantly better than PolyScope (82.0% vs 69.2%; P  =  .022). No statistically significant difference existed in single-session or overall stone-free rate, complication rate, and hospital stay. Mean operation time of PolyScope group was 92.6      20.2  minutes, 9  minutes (10.8%) longer than that of URF @entity2 group 83.3      17.1  minutes (P  <  .01). CONCLUSION: PolyScope demonstrates similar overall stone clearance rate to a conventional flexible ureteroscope in managing @entity1  <3  cm in diameter, but for lower pole stones, it is of inferior efficacy and it is more skillfully demanding, taking longer operation time.

title: Comparing the Efficacy of a Multimodular Flexible Ureteroscope With Its Conventional Counterpart in the Management of XXXX .

answer: @entity1


abstract: OBJECTIVE: To present a descriptive study on same-day discharge after total laparoscopic hysterectomy (TLH), documenting the effectiveness of our pre- and postoperative protocol, and surgical technique for minimizing @entity2 scores in case of uterine volume equivalent to < 14 weeks of gestation. DESIGN: Prospective observational study. SETTING: University hospital. POPULATION: One hundred and five @entity0 undergoing TLH, with same-day discharge. METHODS: Anesthesia and surgery were performed using the same protocol in all @entity0 . MAIN OUTCOME MEASURES: Primary endpoints evaluated @entity1 scores using visual analog scale (VAS). Secondary endpoints included duration of surgery, operating room occupancy, time until discharge, overnight hospitalization, complication rate, readmission rate and @entity0 satisfaction. RESULTS: 100% of @entity0 were able to return home within 4.9  1.4 hours of surgery. One hour after surgery, the VAS score was <4 (3.5  2.6), dropping to <2 4 hours after surgery (1.9  1.2) and remaining so throughout day one (1.8  1.4). VAS scores at 4 hours, evening and day one were thus significantly lower than the VAS score at 1 hour. CONCLUSION: Our results clearly confirm that outpatient TLH is a feasible procedure, allowing same-day discharge and generating low levels of @entity1 . @entity0 can leave hospital in less than 5 hours. Standardized techniques, as well as coordination with the anesthesiologist, adequate postoperative nursing care and preoperative @entity0 counselling, are nevertheless required.

title: Low XXXX score after total laparoscopic hysterectomy and same-day discharge within less than 5 hours: results of a prospective observational study.

answer: @entity1


abstract: UNASSIGNED: @entity2 antibiotics, such as @entity1 , may induce premature termination codon (PTC) readthrough and elude the nonsense-mediated mRNA decay mechanism. Because PTCs are frequently involved in lysosomal diseases, readthrough compounds may be useful as potential therapeutic agents. The aim of our study was to identify @entity0 responsive to @entity1 treatment in order to be used as positive controls to further screen for other PTC readthrough compounds. With this aim, fibroblasts from 11 @entity0 affected by 6 different lysosomal diseases carrying PTCs were treated with @entity1 . Treatment response was evaluated by measuring enzymatic activity, abnormal metabolite accumulation, mRNA expression, protein localization, and cell viability. The potential effect of readthrough was also analyzed by in silico predictions. Results showed that fibroblasts from 5/11 @entity0 exhibited an up to 3-fold increase of enzymatic activity after @entity1 treatment. Accordingly, cell lines tested showed enhanced well-localized protein and/or increased mRNA expression levels and/or reduced metabolite accumulation. Interestingly, these cell lines also showed increased enzymatic activity after @entity3 treatment, which is a PTC readthrough-promoting compound. In conclusion, our results provide a proof-of-concept that PTCs can be effectively suppressed by readthrough drugs, with different efficiencies depending on the genetic context. The screening of new compounds with readthrough activity is a strategy that can be used to develop efficient therapies for diseases caused by PTC mutations.

title: Effect of Readthrough Treatment in Fibroblasts of XXXX Affected by Lysosomal Diseases Caused by Premature Termination Codons.

answer: @entity0


abstract: PURPOSE: In 1986, the risk of @entity1 prompted German authorities to restrict the indications for @entity2 use. After an initial decline, prescriptions increased from <20 million defined daily doses in 1990 to >140 million in 2012. Concurrently, spontaneous reports of @entity1 increased from about 10 in 1990 to >50 in 2012. In this study, reports were analyzed to identify targets for risk minimization measures. METHODS: Reports of suspected @entity2 -induced @entity1 (neutrophils <0.5   *   10(9)  cells/l) between 1990 and 2012 were identified in the German spontaneous reporting database. Cases for which original reporting documents were available were eligible for analysis. @entity0 characteristics, indication, clinical course, and outcome were assessed. RESULTS: One hundred sixty-one reports were analyzed. The mean age of the @entity0 was 56.8  years (11-93) and 64.6  % were female. Off-label use was identified in about 25  % of cases. Neutrophils fell below 100/ l in 63 and intercurrent infections developed in 109 cases. Thirty-eight @entity0 (23.6  %) died. In two thirds of the cases, @entity1 occurred within 6  weeks of permanent or intermittent @entity2 treatment, in 30.5  % within 7  days, including 18 cases of immediate onset after the first or second administration. CONCLUSION: The reported cases show severe clinical courses and are, to some extent, a result of off-label use. Due to the absence of individual risk factors and presence of variable onset patterns, risk minimization measures should focus on restricting use to defined clinical situations and providing concise risk information for @entity0 and healthcare professionals.

title: @entity2 ( @entity2 )-associated XXXX . An analysis of German spontaneous reports 1990-2012.

answer: @entity1


abstract: PURPOSE: In 1986, the risk of @entity1 prompted German authorities to restrict the indications for @entity2 use. After an initial decline, prescriptions increased from <20 million defined daily doses in 1990 to >140 million in 2012. Concurrently, spontaneous reports of @entity1 increased from about 10 in 1990 to >50 in 2012. In this study, reports were analyzed to identify targets for risk minimization measures. METHODS: Reports of suspected @entity2 -induced @entity1 (neutrophils <0.5   *   10(9)  cells/l) between 1990 and 2012 were identified in the German spontaneous reporting database. Cases for which original reporting documents were available were eligible for analysis. @entity0 characteristics, indication, clinical course, and outcome were assessed. RESULTS: One hundred sixty-one reports were analyzed. The mean age of the @entity0 was 56.8  years (11-93) and 64.6  % were female. Off-label use was identified in about 25  % of cases. Neutrophils fell below 100/ l in 63 and intercurrent infections developed in 109 cases. Thirty-eight @entity0 (23.6  %) died. In two thirds of the cases, @entity1 occurred within 6  weeks of permanent or intermittent @entity2 treatment, in 30.5  % within 7  days, including 18 cases of immediate onset after the first or second administration. CONCLUSION: The reported cases show severe clinical courses and are, to some extent, a result of off-label use. Due to the absence of individual risk factors and presence of variable onset patterns, risk minimization measures should focus on restricting use to defined clinical situations and providing concise risk information for @entity0 and healthcare professionals.

title: XXXX ( @entity2 )-associated @entity1 . An analysis of German spontaneous reports 1990-2012.

answer: @entity2


abstract: PURPOSE: In 1986, the risk of @entity1 prompted German authorities to restrict the indications for @entity2 use. After an initial decline, prescriptions increased from <20 million defined daily doses in 1990 to >140 million in 2012. Concurrently, spontaneous reports of @entity1 increased from about 10 in 1990 to >50 in 2012. In this study, reports were analyzed to identify targets for risk minimization measures. METHODS: Reports of suspected @entity2 -induced @entity1 (neutrophils <0.5   *   10(9)  cells/l) between 1990 and 2012 were identified in the German spontaneous reporting database. Cases for which original reporting documents were available were eligible for analysis. @entity0 characteristics, indication, clinical course, and outcome were assessed. RESULTS: One hundred sixty-one reports were analyzed. The mean age of the @entity0 was 56.8  years (11-93) and 64.6  % were female. Off-label use was identified in about 25  % of cases. Neutrophils fell below 100/ l in 63 and intercurrent infections developed in 109 cases. Thirty-eight @entity0 (23.6  %) died. In two thirds of the cases, @entity1 occurred within 6  weeks of permanent or intermittent @entity2 treatment, in 30.5  % within 7  days, including 18 cases of immediate onset after the first or second administration. CONCLUSION: The reported cases show severe clinical courses and are, to some extent, a result of off-label use. Due to the absence of individual risk factors and presence of variable onset patterns, risk minimization measures should focus on restricting use to defined clinical situations and providing concise risk information for @entity0 and healthcare professionals.

title: @entity2 ( XXXX )-associated @entity1 . An analysis of German spontaneous reports 1990-2012.

answer: @entity2


abstract: INTRODUCTION: Worldwide, there has been a startling increase in the number of @entity0 who are obese or overweight. Obesity increases the risk of @entity2 and overall mortality. Mobile phone messaging is an important means of @entity0 communication globally. Because the mobile phone can be used anywhere at any time, mobile phone messaging has the potential to manage @entity1 . We investigated the effectiveness of a one-way text messaging intervention for @entity1 . METHODS: @entity0 ' body mass index and waist circumference were measured at the beginning of the programme and again after 12 weeks. The text message group received text messages about exercise, dietary intake, and general information about @entity1 three times a week, while the control group did not receive any text messages from the study. RESULTS: Of the 80 @entity0 , 25 subjects in the text message group and 29 @entity0 in the control group completed the study. After adjusting for baseline body mass index, the body mass index was significantly lower in the text message group than in the control group (27.9 vs 28.3; p   =   0.02). After adjusting for the baseline waist circumference, the difference of waist circumference between the text message group and control group was not significant (93.4 vs 94.6; p   =   0.13). DISCUSSION: The one-way text messaging intervention was a simple and effective way to manage @entity1 . The one-way text messaging intervention may be a useful method for lifestyle modification in obese subjects.

title: A one-way text messaging intervention for XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity7 ( @entity7 ) is a progressive @entity1 with severe @entity5 . It is believed that cellular oxidative stress and augmented @entity2 signaling drives the development of cardiac pathology. Some @entity8 have also been reported. Here we investigate cellular mechanisms responsible for impaired mitochondrial metabolism in @entity4 at early stages of the disease. We employed electrophysiological and imaging techniques to study mitochondrial structure and function in cardiomyocytes from mdx @entity0 , an animal model of @entity7 . Here we show that mitochondrial matrix was progressively oxidized in myocytes isolated from mdx @entity0 . Moreover, an abrupt increase in workload resulted in significantly more pronounced oxidation of mitochondria in dystrophic cells. Electron micrographs revealed a gradually increased number of damaged mitochondria in mdx myocytes. Degradation in mitochondrial structure was correlated with progressive increase in mitochondrial @entity2 sequestration and mitochondrial depolarization, despite a substantial and persistent elevation in resting cytosolic @entity6 levels. Treatment of mdx cells with @entity3 , an inhibitor of mitochondrial permeability transition pore (mPTP), shifted both resting and workload-dependent mitochondrial redox state to the levels recorded in control myocytes. It also significantly reduced workload dependent depolarization of mitochondrial membrane in @entity9 . Overall, our studies highlight age dependent deterioration of mitochondrial function in @entity9 , which seems to be associated with excessive opening of mPTP due to oxidative stress and cellular @entity2 overload.

title: @entity8 during progression of XXXX .

answer: @entity4


abstract: UNASSIGNED: @entity7 ( @entity7 ) is a progressive @entity1 with severe @entity5 . It is believed that cellular oxidative stress and augmented @entity2 signaling drives the development of cardiac pathology. Some @entity8 have also been reported. Here we investigate cellular mechanisms responsible for impaired mitochondrial metabolism in @entity4 at early stages of the disease. We employed electrophysiological and imaging techniques to study mitochondrial structure and function in cardiomyocytes from mdx @entity0 , an animal model of @entity7 . Here we show that mitochondrial matrix was progressively oxidized in myocytes isolated from mdx @entity0 . Moreover, an abrupt increase in workload resulted in significantly more pronounced oxidation of mitochondria in dystrophic cells. Electron micrographs revealed a gradually increased number of damaged mitochondria in mdx myocytes. Degradation in mitochondrial structure was correlated with progressive increase in mitochondrial @entity2 sequestration and mitochondrial depolarization, despite a substantial and persistent elevation in resting cytosolic @entity6 levels. Treatment of mdx cells with @entity3 , an inhibitor of mitochondrial permeability transition pore (mPTP), shifted both resting and workload-dependent mitochondrial redox state to the levels recorded in control myocytes. It also significantly reduced workload dependent depolarization of mitochondrial membrane in @entity9 . Overall, our studies highlight age dependent deterioration of mitochondrial function in @entity9 , which seems to be associated with excessive opening of mPTP due to oxidative stress and cellular @entity2 overload.

title: XXXX during progression of @entity4 .

answer: @entity8


abstract: BACKGROUND AND PURPOSE: The safety and efficiency of the dual-layer Woven EndoBridge (WEB) device has already been published. However, this international multicenter study sought to evaluate the safety of single-layer devices, which are the newest generation of the WEB intrasaccular flow-disrupter family. They have been designed to offer smaller-sized devices with a lower profile to optimize navigability and delivery, which may, in turn, broaden their range of use. MATERIALS AND METHODS: Data from all consecutive @entity0 treated with a single-layer WEB device, in 10 European centers from June 2013 to May 2014 were included. Clinical presentations, technical details, intra- and perioperative complications, and outcomes at discharge were recorded. Clinical and angiographic data at last follow-up were also analyzed when available. RESULTS: Ninety @entity0 with 98 WEB-treated @entity2 were included in this study. In 93 cases (95%), WEB placement was possible. Complete occlusion at the end of the procedure was obtained in 26 instances (26%). Additional treatment during the procedure (coiling and/or stent placement) was necessary in 12 cases (12.7%). Procedure-related complications occurred in 13 cases, leading to permanent @entity1 in 4 @entity0 (4.4%). Early vascular imaging follow-up data were available for 44 @entity0 (57%), with an average time interval of 3.3 months. Treatment-related morbidity and mortality rates at last follow-up were 2.2% and 1.1%, respectively. CONCLUSIONS: In this study, the feasibility and safety of the single-layer WEB device was comparable with that of the double-layer. However, further studies are needed to evaluate long-term efficacies.

title: Single-Layer WEBs: Intrasaccular Flow Disrupters for XXXX Treatment-Feasibility Results from a European Study.

answer: @entity2


abstract: BACKGROUND: Obesity is a risk factor for some types of @entity0 . Angiogenesis is a necessary step in the multistage progression of @entity0 such as @entity3 . Previous studies reported that @entity7 ( @entity7 ) regulates angiogenesis by activating the @entity8 on endothelial cells. The present study examined the effects of the @entity8 antagonist on @entity0 weight, angiogenesis and serum levels of @entity5 ( @entity5 ), @entity6 ( @entity6 ), and @entity4 (NO). METHODS: Twenty four male C57BL/6 @entity1 were divided into control and @entity2 groups. The control group was fed a normal diet whereas the @entity2 group was fed a high fat diet. After 16 weeks, 2*10(6) @entity1 @entity3 cells were injected subcutaneously into all animals. Half of the control and the @entity2 animals received 1   M, 100   L/kg @entity8 antagonist ( @entity9 ) intraperitoneally. After two weeks, the animals were sacrificed, and angiogenic factors and @entity0 weights and angiogenesis were analyzed. RESULTS: Tumor weight in the @entity2 @entity1 was higher than in the control (p<0.05). Treatment with @entity9 reduced @entity0 weight in the @entity2 animals (p<0.05), without effect on control group (p>0.05). Administration of an @entity8 antagonist decreased @entity0 angiogenesis (evaluated as capillary density/mm2) and serum @entity5 concentration in the @entity2 group without altering serum @entity6 and NO concentrations. CONCLUSIONS: Blockade of the @entity8 suppressed @entity0 growth in @entity2 @entity1 by affecting @entity0 angiogenesis. Thus, it seems that @entity7 and its @entity8 antagonist might be new targets in @entity3 therapy.

title: Effect of Blocking of @entity7 XXXX on Tumor Angiogenesis and Progression in Normal and Diet-Induced Obese C57BL/6 @entity1 .

answer: @entity8


abstract: BACKGROUND: Obesity is a risk factor for some types of @entity0 . Angiogenesis is a necessary step in the multistage progression of @entity0 such as @entity3 . Previous studies reported that @entity7 ( @entity7 ) regulates angiogenesis by activating the @entity8 on endothelial cells. The present study examined the effects of the @entity8 antagonist on @entity0 weight, angiogenesis and serum levels of @entity5 ( @entity5 ), @entity6 ( @entity6 ), and @entity4 (NO). METHODS: Twenty four male C57BL/6 @entity1 were divided into control and @entity2 groups. The control group was fed a normal diet whereas the @entity2 group was fed a high fat diet. After 16 weeks, 2*10(6) @entity1 @entity3 cells were injected subcutaneously into all animals. Half of the control and the @entity2 animals received 1   M, 100   L/kg @entity8 antagonist ( @entity9 ) intraperitoneally. After two weeks, the animals were sacrificed, and angiogenic factors and @entity0 weights and angiogenesis were analyzed. RESULTS: Tumor weight in the @entity2 @entity1 was higher than in the control (p<0.05). Treatment with @entity9 reduced @entity0 weight in the @entity2 animals (p<0.05), without effect on control group (p>0.05). Administration of an @entity8 antagonist decreased @entity0 angiogenesis (evaluated as capillary density/mm2) and serum @entity5 concentration in the @entity2 group without altering serum @entity6 and NO concentrations. CONCLUSIONS: Blockade of the @entity8 suppressed @entity0 growth in @entity2 @entity1 by affecting @entity0 angiogenesis. Thus, it seems that @entity7 and its @entity8 antagonist might be new targets in @entity3 therapy.

title: Effect of Blocking of XXXX @entity8 on Tumor Angiogenesis and Progression in Normal and Diet-Induced Obese C57BL/6 @entity1 .

answer: @entity7


abstract: BACKGROUND: Obesity is a risk factor for some types of @entity0 . Angiogenesis is a necessary step in the multistage progression of @entity0 such as @entity3 . Previous studies reported that @entity7 ( @entity7 ) regulates angiogenesis by activating the @entity8 on endothelial cells. The present study examined the effects of the @entity8 antagonist on @entity0 weight, angiogenesis and serum levels of @entity5 ( @entity5 ), @entity6 ( @entity6 ), and @entity4 (NO). METHODS: Twenty four male C57BL/6 @entity1 were divided into control and @entity2 groups. The control group was fed a normal diet whereas the @entity2 group was fed a high fat diet. After 16 weeks, 2*10(6) @entity1 @entity3 cells were injected subcutaneously into all animals. Half of the control and the @entity2 animals received 1   M, 100   L/kg @entity8 antagonist ( @entity9 ) intraperitoneally. After two weeks, the animals were sacrificed, and angiogenic factors and @entity0 weights and angiogenesis were analyzed. RESULTS: Tumor weight in the @entity2 @entity1 was higher than in the control (p<0.05). Treatment with @entity9 reduced @entity0 weight in the @entity2 animals (p<0.05), without effect on control group (p>0.05). Administration of an @entity8 antagonist decreased @entity0 angiogenesis (evaluated as capillary density/mm2) and serum @entity5 concentration in the @entity2 group without altering serum @entity6 and NO concentrations. CONCLUSIONS: Blockade of the @entity8 suppressed @entity0 growth in @entity2 @entity1 by affecting @entity0 angiogenesis. Thus, it seems that @entity7 and its @entity8 antagonist might be new targets in @entity3 therapy.

title: Effect of Blocking of @entity7 @entity8 on Tumor Angiogenesis and Progression in Normal and Diet-Induced Obese C57BL/6 XXXX .

answer: @entity1


abstract: OBJECTIVE: To evaluate the correlation between overweight and @entity3 and prognosis after radical hepatectomy for @entity1 ( @entity1 ). METHODS: A total of 192 @entity0 who underwent hepatectomy for colorectal liver metastases between January 2000 and March 2012 were eligible for the study. We retrospectively summarized their clinicopathological data, BMI index and @entity3 , and investigated the relation between these data and complications and prognosis. RESULTS: Of the 192 @entity0 , 109 cases were classified as overweight with a BMI >= 24 and 83 @entity0 were classified as non-overweight with a BMI <24. Seventy-five complications occurred in 68 of the 192 @entity0 (35.4%) who underwent hepatectomy. @entity4 (P=0.428), operation time (P=0.837), and @entity2 (P=0.272) were not statistically significantly associated with BMI. 173 @entity0 were included to analyze the influence of overweight on oncologic outcome. The median survival for the overweight @entity0 was 59 months, while that of non-overweight @entity0 was 31 months (P=0.016). The overweight @entity0 had a longer OS assessed by both univariate analysis (P=0.016) and multivariate analysis (P=0.031). However, no statistical differences in disease-free survival (DFS) were detected between the overweight and non-overweight groups (P=0.058). CONCLUSIONS: Overweight is not independently associated with an increasing complication rate. BMI does not significantly affect the @entity1 -DFS, and high BMI @entity0 might have a better overall survival.

title: [Impact of overweight on @entity3 and oncological outcome after radical hepatectomy for metastatic XXXX ].

answer: @entity1


abstract: OBJECTIVE: To evaluate the correlation between overweight and @entity3 and prognosis after radical hepatectomy for @entity1 ( @entity1 ). METHODS: A total of 192 @entity0 who underwent hepatectomy for colorectal liver metastases between January 2000 and March 2012 were eligible for the study. We retrospectively summarized their clinicopathological data, BMI index and @entity3 , and investigated the relation between these data and complications and prognosis. RESULTS: Of the 192 @entity0 , 109 cases were classified as overweight with a BMI >= 24 and 83 @entity0 were classified as non-overweight with a BMI <24. Seventy-five complications occurred in 68 of the 192 @entity0 (35.4%) who underwent hepatectomy. @entity4 (P=0.428), operation time (P=0.837), and @entity2 (P=0.272) were not statistically significantly associated with BMI. 173 @entity0 were included to analyze the influence of overweight on oncologic outcome. The median survival for the overweight @entity0 was 59 months, while that of non-overweight @entity0 was 31 months (P=0.016). The overweight @entity0 had a longer OS assessed by both univariate analysis (P=0.016) and multivariate analysis (P=0.031). However, no statistical differences in disease-free survival (DFS) were detected between the overweight and non-overweight groups (P=0.058). CONCLUSIONS: Overweight is not independently associated with an increasing complication rate. BMI does not significantly affect the @entity1 -DFS, and high BMI @entity0 might have a better overall survival.

title: [Impact of overweight on XXXX and oncological outcome after radical hepatectomy for metastatic @entity1 ].

answer: @entity3


abstract: Central nervous system (CNS) relapse occurs in around 5% of @entity6 ( @entity6 ) cases. No biomarkers to identify high-risk @entity0 have been discovered. We evaluated the expression of lymphocyte-guiding chemokine receptors in systemic and CNS @entity4 . Immunohistochemical staining for @entity3 , @entity9 , @entity7 , @entity5 , and @entity8 was performed on 89 tissue samples, including cases of @entity1 ( @entity1 ), secondary @entity1 (sCNSL), and systemic @entity6 . Also, 10 reactive lymph node samples were included. Immunoelectron microscopy was performed on two PCNSLs, one sCNSL, one systemic @entity6 , and one reactive lymph node samples, and staining was performed for @entity3 , @entity9 , @entity5 , and @entity8 . Chi-square test was used to determine correlations between clinical parameters, diagnostic groups, and @entity3 expression. Strong nuclear @entity3 positivity correlated with systemic @entity6 , whereas strong cytoplasmic @entity9 positivity correlated with CNS involvement (P  =  0.003 and P  =  0.039). Immunoelectron microscopy revealed a nuclear @entity3 staining in reactive lymph node, compared with cytoplasmic and membranous localization seen in CNS @entity4 . We found that @entity1 presented a @entity3 profile different from @entity2 . Our findings give new information on the CNS tropism of @entity6 and, if confirmed, may contribute to more effective targeting of CNS prophylaxis among @entity0 with @entity6 .

title: Similar XXXX profiles in @entity4 with central nervous system involvement - possible biomarkers for @entity0 selection for central nervous system prophylaxis, a retrospective study.

answer: @entity3


abstract: Central nervous system (CNS) relapse occurs in around 5% of @entity6 ( @entity6 ) cases. No biomarkers to identify high-risk @entity0 have been discovered. We evaluated the expression of lymphocyte-guiding chemokine receptors in systemic and CNS @entity4 . Immunohistochemical staining for @entity3 , @entity9 , @entity7 , @entity5 , and @entity8 was performed on 89 tissue samples, including cases of @entity1 ( @entity1 ), secondary @entity1 (sCNSL), and systemic @entity6 . Also, 10 reactive lymph node samples were included. Immunoelectron microscopy was performed on two PCNSLs, one sCNSL, one systemic @entity6 , and one reactive lymph node samples, and staining was performed for @entity3 , @entity9 , @entity5 , and @entity8 . Chi-square test was used to determine correlations between clinical parameters, diagnostic groups, and @entity3 expression. Strong nuclear @entity3 positivity correlated with systemic @entity6 , whereas strong cytoplasmic @entity9 positivity correlated with CNS involvement (P  =  0.003 and P  =  0.039). Immunoelectron microscopy revealed a nuclear @entity3 staining in reactive lymph node, compared with cytoplasmic and membranous localization seen in CNS @entity4 . We found that @entity1 presented a @entity3 profile different from @entity2 . Our findings give new information on the CNS tropism of @entity6 and, if confirmed, may contribute to more effective targeting of CNS prophylaxis among @entity0 with @entity6 .

title: Similar @entity3 profiles in XXXX with central nervous system involvement - possible biomarkers for @entity0 selection for central nervous system prophylaxis, a retrospective study.

answer: @entity4


abstract: Central nervous system (CNS) relapse occurs in around 5% of @entity6 ( @entity6 ) cases. No biomarkers to identify high-risk @entity0 have been discovered. We evaluated the expression of lymphocyte-guiding chemokine receptors in systemic and CNS @entity4 . Immunohistochemical staining for @entity3 , @entity9 , @entity7 , @entity5 , and @entity8 was performed on 89 tissue samples, including cases of @entity1 ( @entity1 ), secondary @entity1 (sCNSL), and systemic @entity6 . Also, 10 reactive lymph node samples were included. Immunoelectron microscopy was performed on two PCNSLs, one sCNSL, one systemic @entity6 , and one reactive lymph node samples, and staining was performed for @entity3 , @entity9 , @entity5 , and @entity8 . Chi-square test was used to determine correlations between clinical parameters, diagnostic groups, and @entity3 expression. Strong nuclear @entity3 positivity correlated with systemic @entity6 , whereas strong cytoplasmic @entity9 positivity correlated with CNS involvement (P  =  0.003 and P  =  0.039). Immunoelectron microscopy revealed a nuclear @entity3 staining in reactive lymph node, compared with cytoplasmic and membranous localization seen in CNS @entity4 . We found that @entity1 presented a @entity3 profile different from @entity2 . Our findings give new information on the CNS tropism of @entity6 and, if confirmed, may contribute to more effective targeting of CNS prophylaxis among @entity0 with @entity6 .

title: Similar @entity3 profiles in @entity4 with central nervous system involvement - possible biomarkers for XXXX selection for central nervous system prophylaxis, a retrospective study.

answer: @entity0


abstract: PURPOSE: To define the socioeconomic and demographic determinants for self-rated health and happiness for Turkish elderly (>= 60) using the World Values Survey (WVS) database. METHODS: WVS data for @entity1 covering 23 years (1990-2013) with five separate cross-sections (1990, 1996, 2001, 2007, 2013) were pooled for analysis (n=870). Dependent variables were self-rated health (SRH) and perception of happiness.Their relation with age, sex, number of @entity0 , marital status, income, education, employment status and class perception were evaluated. Chi-square and logistic regression analysis were used. Regression coefficients and their standard errors were derived to calculate odds ratios. RESULTS: Mean age was 66.96  5.78 (60-91), 58.16% were male and 76.32% were married. The majority (61.10%) was at lowest income level and 80.60% had education attainment at primary level or below. Very happy/quite happy were 81.77% while only 46.59% perceived their health as very good/good. The crisis year (2001) increased the risk of bad self-rated health 4.4 times, being a @entity0 2.0 times, while being a widow had a 2.3-fold, low-income 3.0-fold effect. The odds for unhappy status was increased 4.3 times at low-income levels and 8.4 times for the divorced/separate living partners. @entity2 state improved after crisis period. CONCLUSION: SRH and happiness of Turkish elderly bare demographic and socioeconomic inequalities. The inexistence of a partner, being a @entity0 , low-income level and major threats for it, like economic crisis, are important drivers for elderly health and happiness. To improve well-being of elderly, better social policies for income is essential and at economic crisis times, support policies should be prioritized for vulnerable groups, including elderly.

title: Demographic and socioeconomic inequalities for self-rated health and happiness in elderly: The situation for XXXX regarding World Values Survey between 1990 and 2013.

answer: @entity1


abstract: AIM: Surgery remains the gold standard treatment for @entity0 with stable @entity2 ( @entity2 ). In an attempt to guide operative selection, we report our series of penile-straightening procedures for @entity2 , using a surgical algorithm that recommended tunica albuginea plication (TAP), partial plaque excision and grafting (PEG) or inflatable penile prosthesis (IPP) placement. With this study, we attempt to further refine surgical approach, define realistic surgical outcomes, and help establish reasonable postoperative expectations for treatment of @entity2 . METHODS: We retrospectively reviewed all @entity0 who underwent surgery for @entity2 at our institution between 2007 and 2013. Work-up involved a history, physical exam, and a duplex ultrasound. Several questionnaires were employed to assess bother and distress associated with @entity2 . Objective outcomes and @entity0 satisfaction were assessed postoperatively. Primary outcomes include postoperative @entity0 satisfaction with @entity3 , curvature, and ability to engage in intercourse. Secondary outcomes include comparing emotional, relationship, and @entity1 to severity of disease. RESULTS: A total of 390 @entity0 underwent penile-straightening procedures for correction of @entity2 . Of these @entity0 , 29%, (n   =   114) underwent TAP, 41% (n   =   159) PEG, and 30% (N   =   114) IPP. Mean follow-up was 17 months. The three surgical modalities showed no significant difference in satisfaction with @entity3 , presence of bothersome residual curve, or ability to engage in intercourse. Preoperatively, 80% of @entity0 reported a negative effect of @entity2 on their emotional status. Postoperatively, 88.4% of @entity0 were able to engage in penetrative intercourse, while only 70% were satisfied with @entity3 and 84.9% were satisfied with curvature correction. CONCLUSION: @entity0 experience with @entity3 , ability to engage in intercourse, and residual bothersome curve was not statistically different across the three groups, supporting the use of this surgical algorithm. The majority of @entity0 with @entity2 experience some @entity1 , which may compromise @entity0 satisfaction. Papagiannopoulos D, Yura E, and Levine L. Examining postoperative outcomes after employing a surgical algorithm for management of @entity2 : A single-institution retrospective review. J Sex Med **;**:**-**.

title: Examining Postoperative Outcomes after Employing a Surgical Algorithm for Management of XXXX : A Single-Institution Retrospective Review.

answer: @entity2


abstract: BACKGROUND: @entity3 (MSP) in @entity0 can be due to non-inflammatory conditions, such as the @entity6 ( @entity6 ) or idiopathic MSP (IMSP). Aim of the study was to evaluate type and persistence of MSP in a cohort of schoolchildren with MSP followed for 3  years, in order to identify the main risk factors. METHODS: Healthy schoolchildren, aged 8-13 years, underwent a general and rheumatologic examination, focusing on presence of chronic MSP, defined as continuous or recurrent @entity1 lasting more than 3  months and heavily interfering with daily life activities, presence of generalized joint @entity5 , the body mass index and the pubertal stage. All symptomatic subjects were re-evaluated 3  years later with the same methods. RESULTS: Seventy of the 88 symptomatic subjects of the initial cohort of 289 were re-evaluated 3  years later. Of these, 38 (54.3  %) still presented MSP, including 19 with @entity6 and 19 with IMSP. Main symptoms were lower limbs @entity4 and @entity2 . MSP persisted more in females than in males (p   =   0.038) and in pubertal rather than pre-pubertal subjects (p   =   0.022); these subjects recovered significantly more both from @entity6 (p   =   0.004) and IMSP (p   =   0.016). Gender did not influence the distribution of MSP according to pubertal stage. CONCLUSIONS: Female gender, @entity6 and pubertal stage are important risk factors for persistence of MSP. Further studies are needed to evaluate the natural history of MSP towards adulthood and the role of the pubertal age.

title: XXXX in schoolchildren across puberty: a 3-year follow-up study.

answer: @entity3


abstract: UNASSIGNED: We report our initial clinical experience for image quality and diagnostic performance of a @entity3 ( @entity3 , Philips Healthcare) compared with an analog PET with time-of-flight (GeminiTF PET/CT, Philips Healthcare). METHODS: Twenty-one oncologic @entity0 , mean age 58, first underwent clinical FDG PET/CT on the GeminiTF. The scanner table was then withdrawn while the @entity0 remained on the table, and the @entity3 was inserted between the GeminiTF PET and CT scanner. The @entity0 were scanned for a second time using the same PET field of view with CT from GeminiTF for attenuation correction. Two readers reviewed the two sets of PET/CT images for overall image quality, lesion conspicuity and sharpness. They counted the number of suspicious, FDG avid lesions and provided the TNM staging for the five @entity0 referred for initial staging. Standardized uptake values (SUV) and SUV gradients as a measure of lesion sharpness were obtained. RESULTS: @entity3 showed better image quality compared with GeminiTF. In side-by-side comparison using a 5-point scale, lesion conspicuity (4.3    0.6), lesion sharpness (4.3    0.6) and diagnostic confidence (3.4    0.7) were better with @entity3 compared with GeminiTF, P < 0.01. In 52 @entity2 , lesion maximum SUV was 36% higher with @entity3 than with GeminiTF, lesion-to-blood pool SUV ratio was 59% higher and SUV gradient was 51% higher, with good correlation between the two scanners. Lesions < 1.5 cm showed a greater increase in SUV from GeminiTF to @entity3 compared to those >=  1.5 cm. @entity3 showed additional eight suspicious lesions in 5 of 21 @entity0 that were not seen at GeminiTF. In the 15 restaging @entity0 , the true negative rate was 100% and true positive rate was 78% for both scanners. In the five @entity0 for initial staging, @entity3 lead to upstaging in two @entity0 and showed the same staging in the other three @entity0 compared with GeminiTF. CONCLUSION: @entity3 provides better image quality, diagnostic confidence and accuracy compared with GeminiTF. It may be most beneficial in detecting small @entity1 lesions and disease staging.

title: Image quality and diagnostic performance of a digital PET prototype in XXXX with oncologic diseases: Initial experience and comparison with analog PET.

answer: @entity0


abstract: AIM: The prediction of return of spontaneous circulation (ROSC) during resuscitation of @entity0 suffering of @entity3 (CA) is particularly challenging. Regional cerebral @entity1 saturation (rSO2) monitoring through near-infrared spectrometry is feasible during CA and could provide guidance during resuscitation. METHODS: We conducted a systematic review and meta-analysis on the value of rSO2 in predicting ROSC both after @entity2 ( @entity2 ) or out-of-hospital (OH) CA. Our search included MEDLINE (PubMed) and EMBASE, from inception until April 4th, 2015. We included studies reporting values of rSO2 at the beginning of and/or during resuscitation, according to the achievement of ROSC. RESULTS: A total of nine studies with 315 @entity0 (119 achieving ROSC, 37.7%) were included in the meta-analysis. The majority of those @entity0 had an OHCA (n=225, 71.5%; IHCA: n=90, 28.5%). There was a significant association between higher values of rSO2 and ROSC, both in the overall calculation (standardized mean difference, SMD -1.03; 95%CI -1.39,-0.67; p<0.001), and in the subgroups analyses (rSO2 at the beginning of resuscitation: SMD -0.79; 95%CI -1.29,-0.30; p=0.002; averaged rSO2 value during resuscitation: SMD -1.28; 95%CI -1.74,-0.83; p<0.001). CONCLUSIONS: Higher initial and average regional cerebral @entity1 saturation values are both associated with greater chances of achieving ROSC in @entity0 suffering of CA. A note of caution should be made in interpreting these results due to the small number of @entity0 and the heterogeneity in study design: larger studies are needed to clinically validate cut-offs for guiding cardiopulmonary resuscitation.

title: Cerebral oximetry and return of spontaneous circulation after XXXX : A systematic review and meta-analysis.

answer: @entity3


abstract: UNASSIGNED: The use of engineered nano-sized materials led to revolutionary developments in many industrial applications and in the medical field. These materials, however, also may cause @entity1 . In addition to size, surface properties and shape were identified as relevant parameters for cell damage. @entity0 may occur as disruption of membrane integrity, induction of apoptosis and by organelle damage. Generation of oxidative stress may serve as an indicator for @entity1 . Effects occurring upon short contact of particles with cells, for instance in the @entity4 , could be identified according to increases of intracellular [ @entity2 ] levels, which are caused by variety of toxic stimuli. Negatively charged, neutral and positively charged @entity3 particles of different sizes were used to study the role of size and surface properties on viability, membrane disruption, apoptosis, lysosome function, intracellular [ @entity2 ] levels and generation of oxidative stress. @entity5 particles served to test this hypothesis. Twenty nm @entity3 particles as well as 12 nm and 40 nm @entity5 particles caused membrane damage and apoptosis with no preference of the surface charge. Only 20 nm plain and @entity6 functionalized @entity3 particles cause oxidative stress and only the plain particles lysosomal damage. A potential role of surface charge was identified for 200 nm @entity3 particles, where only the @entity7 particles caused lysosomal damage. Increases in intracellular [ @entity2 ] levels and @entity1 after 24 h was often linked but determination of intracellular [ @entity2 ] levels could serve to characterize further the type of membrane damage.    2015 The Authors. Journal of Applied Toxicology Published by John Wiley _ Sons Ltd.

title: Intracellular calcium levels as screening tool for nanoparticle XXXX .

answer: @entity1


abstract: UNASSIGNED: Physiological stimuli such as thrombin, or pathological stimuli such as @entity5 ( @entity6 ), activate platelets circulating in blood. Once activated, platelets bind to monocytes via @entity8 - @entity4 interactions, but also release the stored contents of their granules. These platelet releasates, in addition to direct platelet binding, activate monocytes and facilitate their recruitment to @entity1 sites. Consequently, understanding the changes platelet releasates induce in monocyte membrane proteins is critical. We studied the glyco-proteome changes of @entity2 monocytic cells affected by @entity6 - or thrombin-induced platelet releasates. We employed lectin affinity chromatography combined with filter aided sample preparation to improve glyco- and membrane protein coverage. Using SILAC, we quantified 1,715 proteins, including 852 membrane and 500 glycoproteins, identifying the up-regulation of multiple proteins involved in monocyte extracellular matrix binding and transendothelial migration. Flow cytometry validated expression changes of integrin a5, integrin b1, @entity3 and @entity4 . The observed increase in monocyte adhesion to fibronectin was determined to be mediated by the up-regulation of @entity9 ( @entity9 , or integrin a5b1) via a @entity8 - @entity4 independent mechanism. This novel aspect could be validated on @entity7 + @entity0 primary monocytes, highlighting the benefits of the improved enrichment method regarding high membrane protein coverage and reliable quantification.

title: Quantitative Glycoproteomic Analysis identifies Platelet-induced Increase of Monocyte Adhesion via the Up-regulation of XXXX .

answer: @entity9


abstract: OBJECTIVE: Our objective was to present normative data from 70-year-olds on the Integrated Visual and Auditory Continuous Performance Test ( @entity4 ), a computerized measure of attention and response control. METHOD: 640 @entity0 (330 @entity0 and 310 @entity0 ), all aged 70  years, completed the @entity4 , as well as the Mini-Mental State Examination and the Geriatric Depression Scale. RESULTS: Data were stratified by education and gender. Education differences were found in 11 of 22 @entity4 scales. Minor gender differences were found in six scales for the high-education group, and two scales for the low-education group. Comparisons of healthy @entity0 and @entity0 with @entity2 , @entity3 , or @entity1 showed only minor differences. Correlations among @entity4 scales were strong (all r   >   .34, p   <   .001), and those with the widely used Mini-Mental State Examination were weaker (all r   <   .21, p   <   .05). Skewed distributions of normative data from primary @entity4 scales measuring response inhibition (Prudence) and inattention (Vigilance) represent a weakness of this test. CONCLUSIONS: This study provides @entity4 norms for 70-year-olds stratified by education and gender, increasing the usability of this instrument when testing @entity0 near this age. The data presented here show some major differences from original @entity4 norms, and explanations for these differences are discussed. Explanations include the broad age-range used in the original @entity4 norms (66-99  years of age) and the passage of 15  years since the original norms were collected.

title: Attention in Older Adults: A Normative Study of the Integrated Visual and Auditory Continuous Performance Test for XXXX Aged 70 Years.

answer: @entity0


abstract: BACKGROUND: Sternotomy for @entity3 ( @entity3 ) is associated with greater morbidity than a cervical approach to thyroidectomy. We sought to identify predictors for sternotomy as a surgical approach for the removal of @entity3 and analyzed the preoperative and postoperative characteristics of @entity0 with @entity3 compared with those with large goiters contained entirely within the neck or a cervical @entity2 . METHODS: A retrospective review of a surgical database was performed. We included @entity0 with large (>100  g) thyroids or @entity3 , regardless of size. Between 1995 and 2013, 220 @entity0 met these criteria. Comparisons were made between @entity0 who had an @entity3 and @entity0 who had a cervical @entity2 with particular focus on those who required sternotomy. RESULTS: Of the 220 @entity0 , 127 @entity0 (58%) had @entity3 , of whom 7 (5.5%) required sternotomy. All @entity0 who underwent sternotomy underwent preoperative computed tomography scanning and were more likely to have preoperative symptoms of chest pressure and voice complaints and have extension of the thyroid gland below the aortic arch. Sternotomy took an average of 2  hours longer than a cervical incision, was associated with significantly more @entity1 (600 versus 190  mL, P  =  0.04), and a longer length of stay (3.1 versus 1.8  d, P  =  0.03) than cervical thyroidectomy. CONCLUSIONS: Sternotomy for @entity3 is rare. All @entity0 necessitating sternotomy had extension below the aortic arch and were more likely to present complaining of chest pressure and voice issues.

title: XXXX : when is a sternotomy required?

answer: @entity3


abstract: BACKGROUND: Controversy exists over optimal timing of tracheostomy in @entity0 with @entity5 after @entity1 . The study aimed to determine whether the timing of tracheostomy affects mortality in this population. METHODS: The 2008-2011 National Trauma Data Bank was queried to identify @entity1 @entity0 without concomitant @entity2 who required tracheostomy for @entity5 between hospital days 4 and 21. Restricted cubic spline analysis was performed to evaluate the relationship between tracheostomy timing and the odds of inhospital mortality. The cohort was stratified based on this analysis. Unadjusted characteristics and outcomes were compared. Multivariable logistic regression was used to evaluate the effect of tracheostomy timing on mortality after adjustment for age, gender, race, payor status, level of @entity1 center, injury severity score, presentation @entity3 scale, and @entity4 and abdominal abbreviated injury score. RESULTS: There were 9662 @entity0 included in the study. Restricted cubic spline analysis demonstrated a nonlinear relationship between timing of tracheostomy and mortality, with higher odds of mortality occurring with tracheostomy placement within 10  d of admission compared with later time points. The cohort was therefore stratified into early and delayed tracheostomy groups relative to this time point. The resulting groups contained 5402 (55.9%) and 4260 (44.1%) @entity0 , respectively. After multivariable adjustment, the delayed tracheostomy group continued to have significantly reduced odds of mortality (Adjusted odds ratio, 0.82, 95% confidence interval, 0.71-0.95, C-statistic, 0.700). CONCLUSIONS: Among non-head injured @entity1 @entity0 with prolonged @entity5 , tracheostomy placement within 10  d of admission may result in increased mortality compared with later time points.

title: Optimal timing of tracheostomy after @entity1 without associated XXXX .

answer: @entity2


abstract: BACKGROUND: Controversy exists over optimal timing of tracheostomy in @entity0 with @entity5 after @entity1 . The study aimed to determine whether the timing of tracheostomy affects mortality in this population. METHODS: The 2008-2011 National Trauma Data Bank was queried to identify @entity1 @entity0 without concomitant @entity2 who required tracheostomy for @entity5 between hospital days 4 and 21. Restricted cubic spline analysis was performed to evaluate the relationship between tracheostomy timing and the odds of inhospital mortality. The cohort was stratified based on this analysis. Unadjusted characteristics and outcomes were compared. Multivariable logistic regression was used to evaluate the effect of tracheostomy timing on mortality after adjustment for age, gender, race, payor status, level of @entity1 center, injury severity score, presentation @entity3 scale, and @entity4 and abdominal abbreviated injury score. RESULTS: There were 9662 @entity0 included in the study. Restricted cubic spline analysis demonstrated a nonlinear relationship between timing of tracheostomy and mortality, with higher odds of mortality occurring with tracheostomy placement within 10  d of admission compared with later time points. The cohort was therefore stratified into early and delayed tracheostomy groups relative to this time point. The resulting groups contained 5402 (55.9%) and 4260 (44.1%) @entity0 , respectively. After multivariable adjustment, the delayed tracheostomy group continued to have significantly reduced odds of mortality (Adjusted odds ratio, 0.82, 95% confidence interval, 0.71-0.95, C-statistic, 0.700). CONCLUSIONS: Among non-head injured @entity1 @entity0 with prolonged @entity5 , tracheostomy placement within 10  d of admission may result in increased mortality compared with later time points.

title: Optimal timing of tracheostomy after XXXX without associated @entity2 .

answer: @entity1


abstract: UNASSIGNED: The @entity1 bean (Vigna umbellata) root apex specifically secretes @entity2 through expression activation of Vigna umbellata Multidrug and Toxic Compound Extrusion 1 (VuMATE1) under @entity3 ( @entity5 ) stress. However, the underlying mechanisms regulating VuMATE1 expression remain unknown. We isolated and characterized a gene encoding Sensitive to Proton Rhizotoxicity1 (STOP1)-like protein, VuSTOP1, from @entity1 bean. The role of VuSTOP1 in regulating VuMATE1 expression was investigated using the @entity0 one-hybrid assay. We characterized the function of VuSTOP1 in @entity5   - and @entity4 -tolerance using in planta complementation assays. We demonstrated that VuSTOP1 has transactivation potential. We found that VuSTOP1 expression is inducible by @entity5 and @entity4 stress. However, although VuSTOP1 binds to the promoter of VuMATE1, the inconsistent tissue localization patterns of VuSTOP1 and VuMATE1 preclude VuSTOP1 as the major factor regulating VuMATE1 expression. In addition, when a protein translation inhibitor increased expression of VuSTOP1, VuMATE1 expression was inhibited. In planta complementation assay demonstrated that VuSTOP1 could fully restore expression of genes involved in @entity4 tolerance, but could only partially restore expression of AtMATE. We conclude that VuSTOP1 plays a major role in @entity4 tolerance, but only a minor role in @entity5 tolerance. The differential transcriptional regulation of VuSTOP1 and VuMATE1 reveals a complex regulatory system controlling VuMATE1 expression.

title: Characterization of an inducible C2 H2 -type zinc finger transcription factor VuSTOP1 in @entity1 bean (Vigna umbellata) reveals differential regulation between low pH and XXXX tolerance mechanisms.

answer: @entity3


abstract: UNASSIGNED: The @entity1 bean (Vigna umbellata) root apex specifically secretes @entity2 through expression activation of Vigna umbellata Multidrug and Toxic Compound Extrusion 1 (VuMATE1) under @entity3 ( @entity5 ) stress. However, the underlying mechanisms regulating VuMATE1 expression remain unknown. We isolated and characterized a gene encoding Sensitive to Proton Rhizotoxicity1 (STOP1)-like protein, VuSTOP1, from @entity1 bean. The role of VuSTOP1 in regulating VuMATE1 expression was investigated using the @entity0 one-hybrid assay. We characterized the function of VuSTOP1 in @entity5   - and @entity4 -tolerance using in planta complementation assays. We demonstrated that VuSTOP1 has transactivation potential. We found that VuSTOP1 expression is inducible by @entity5 and @entity4 stress. However, although VuSTOP1 binds to the promoter of VuMATE1, the inconsistent tissue localization patterns of VuSTOP1 and VuMATE1 preclude VuSTOP1 as the major factor regulating VuMATE1 expression. In addition, when a protein translation inhibitor increased expression of VuSTOP1, VuMATE1 expression was inhibited. In planta complementation assay demonstrated that VuSTOP1 could fully restore expression of genes involved in @entity4 tolerance, but could only partially restore expression of AtMATE. We conclude that VuSTOP1 plays a major role in @entity4 tolerance, but only a minor role in @entity5 tolerance. The differential transcriptional regulation of VuSTOP1 and VuMATE1 reveals a complex regulatory system controlling VuMATE1 expression.

title: Characterization of an inducible C2 H2 -type zinc finger transcription factor VuSTOP1 in XXXX bean (Vigna umbellata) reveals differential regulation between low pH and @entity3 tolerance mechanisms.

answer: @entity1


abstract: UNASSIGNED: @entity2 nanoparticles (AgNPs) were extensively used in various fields, particularly in medicine as an antimicrobial agent. The unavoidable and extensive usage of AgNPs in turn accumulates in the environment. Plants are the essential base of ecosystem and are ready to disturb by environmental pollutants. Therefore, in the present study, we have planned to evaluate the impact of biologically synthesized AgNPs on the essential food crop Chinese cabbage (Brassica rapa ssp. pekinensis). The effects of AgNP-induced plant morphological and physiological changes were investigated in different concentrations (100, 250, and 500  mg/L). The results of morphological features showed that AgNPs at lower concentrations (100  mg/L) exhibit growth-stimulating activity, whereas at higher concentrations (250 and 500  mg/L), particularly, 500  mg/L exhibited growth-suppressing activities which are in terms of reduced root, shoot growth, and fresh biomass. The increased reactive @entity0 species (ROS) generation, @entity3 production, @entity4 biosynthesis, and decreased @entity1 content were also more obviously present at higher concentrations of AgNPs. The concentration-dependent DNA damage was observed in the AgNP-treated plants. The molecular responses of AgNPs indicate that most of the genes related to secondary metabolism ( @entity5 , @entity4 ) and antioxidant activities were induced at higher concentrations of AgNP treatment. The dose-dependent phytotoxicity effects of AgNPs were also observed. Taken together, the highest concentration of AgNPs (500  mg/L) could induce growth-suppressing activities via the induction of ROS generation and other molecular changes in B. rapa seedlings.

title: Impact of biologically synthesized XXXX nanoparticles on the growth and physiological responses in Brassica rapa ssp. pekinensis.

answer: @entity2


abstract: AIM: Fibrocystic mastosis (FCM) is defined by the totality of dystrophic changes of the mammary tissue, the grouping in the form of @entity4 of epithelial, cystic, metaplastic and hyperplastic alterations. A very good estimation of the @entity2 risk is related specifically to the microscopic aspect. Other factors, the family history as well as the presence of an inherited gene determining the increase in the risk of @entity0 are also considered. But, if a @entity1 known with @entity8 has not undergone any biopsy, then it is impossible to calculate the specific individual risk of developing @entity2 . MATERIAL AND METHODS: The data collected as a study material and considered refer to: the total num- ber of cases investigated and diagnosed with @entity8 , the annual distribution of this disease cases, the distribution of the cases according to age groups, admission reasons, clinical examination, personal pathologic history clinically significant for the basic disease (the main diagnosis), the family medical history significant for the basic disease, the anatomopathological diagnosis. RESULTS: Between 2004 and 2006, at "Cuza Vod  " Obstetrics and Gynecology Hospital of Ia  i, a maximum number of cases is noticed in 2006, when there were 147 cases, and the lowest number of cases was in 2005. There was high frequency of the anatomopathological examinations that highlighted the presence of @entity3 (both proliferative and non-proliferative), and the second most often diagnosis is @entity7 . Though @entity8 is not clearly defined, it is still admitted that in order to support this diagnosis it is first compulsory to exclude @entity2 . CONCLUSIONS: Only in 5% of the @entity1 with @entity8 cellular changes can be revealed in the form of @entity6 , which are a risk factor for @entity2 . The lesion that delimits @entity2 from non- @entity2 is @entity5 in situ. An incidence of over 20% is present in the countries that use mammographic screening programmes, mammographic surveillance programmes and programmes for the guided localization of nonpalpable lesions of the mammary gland.

title: Benign breast disease and the risk of XXXX in the next 15 years.

answer: @entity0


abstract: The @entity3 functions as the major refractive interface for vision and protects the internal eye from insult. Current understanding of innate immune responses to @entity4 derives from a synthesis of in vitro and in vivo analyses. However, monolayer cell cultures and @entity1 models do not accurately duplicate all aspects of innate immunity in @entity0 @entity0 . Here, we describe a three-dimensional culture system that incorporates @entity0 cells and extracellular matrix to more completely simulate the @entity0 @entity3 for studies of @entity4 . @entity0 corneal stromal fibroblasts were mixed with type I collagen in 3- m pore size transwell inserts, and overlayed with Matrigel to simulate a @entity0 corneal stroma and epithelial basement membrane. These were then infected with a @entity3 -tropic adenovirus, and exposed on their inferior side to leukocytes derived from @entity0 peripheral blood. Subsequent analyses were performed with histology, confocal microscopy, ELISA, and fluorescence-activated cell sorting (FACS). @entity6 , a neutrophil chemokine shown previously as the first cytokine induced in @entity4 of @entity0 corneal cells, increased upon @entity8 of facsimiles in a dose-responsive fashion. @entity7 -positive cells infiltrated infected corneal facsimiles in a sub-Matrigel location, possibly due to @entity6 colocalization with heparan @entity5 , a Matrigel constituent. Cellular infiltration was significantly inhibited by treatment with chemical inhibitors of p38 MAPK and Src kinase, both constituents of a signaling cascade previously suggested to regulate @entity2 after @entity8 . FACS analysis determined that both virus and corneal fibroblasts were necessary for the induction of leukocyte migration into the facsimiles. The corneal facsimile, literally a @entity3 in a test tube, permits mechanistic studies on @entity0 tissue in a highly tractable system.

title: Novel model of innate immunity in XXXX .

answer: @entity4


abstract: The wide-ranging field of cognition enhancing research along with its ethics as it stands today is summarized. In the forefront are potentially novel drugs and non-pharmacological treatments for @entity1 across many different @entity2 . Today's research will bring new drugs to @entity0 tomorrow, and tomorrow's research will bring new molecular targets to clinical development that should be cognitive domain-specific. There is the likelihood that special populations may be better treated and that personalized medicine for @entity1 could become a reality. It is conceivable that with the current research effort, cognition enhancing drugs will become available to wide-ranging populations of @entity0 with @entity2 and to those that are healthy. In some cultures, there is a push in society to be more intelligent or have more cognitive prowess. Thus, the ethical use of cognitive enhancing drugs should be an area of debate and communication. Neuroethics is a growing field and it intends to bring together key contributors such as physicians, disease experts, regulatory officials, and policy makers to discuss how such medicines can or should be made available. Together with this, one has to consider the possibility that no single medicine or technology will have a great impact on cognition and, therefore, combination therapy of drugs plus other approaches like exercise or transcranial direct-current stimulation may be the path forward. This is another area of scientific inquiry and debate, and the results should be fruitful and helpful to @entity0 . The science of cognition is advancing at a rapid rate, and communication of its progress along with the development of rational and ethical policies for use of @entity1 will be beneficial.

title: Closing thoughts for XXXX .

answer: @entity1


abstract: BACKGROUND: The optimal method for obtaining good blood @entity3 control in noncritically ill @entity0 undergoing peripheral vascular surgery remains a topic of debate for surgeons, endocrinologists, and others involved in the care of @entity0 with @entity5 and @entity1 . A prospective trial was performed to evaluate the impact of routine use of a @entity3 management service (GMS) on glycemic control within 24 hours of lower-extremity revascularization (LER). METHODS: In an interrupted time-series design ( @entity6 , 2011-April 30, 2012), surgeon-directed diabetic care (Baseline phase) to routine GMS involvement (Intervention phase) was compared following LER. GMS assumed responsibility for @entity3 management through discharge. The main outcome measure was glycemic control, assessed by (1) mean hospitalization @entity3 and (2) the percentage of recorded @entity3 values within target range. Statistical process control charts were used to assess the impact of the intervention. RESULTS: Clinically important differences in @entity0 demographics were noted between groups; the 19 @entity0 in the Intervention arm had worse @entity4 than the 19 @entity0 in the Baseline arm (74% critical limb @entity2 versus 58%; p = .63). Routine use of GMS significantly reduced mean hospitalization @entity3 (191 mg/dL Baseline versus 150 mg/dL Intervention, p < .001). Further, the proportion of @entity3 values in target range increased (48% Baseline versus 78% Intervention, p = .05). Following removal of GMS involvement, measures of glycemic control did not significantly decrease for the 19 postintervention @entity0 . CONCLUSIONS: Routine involvement of GMS improved glycemic control in @entity0 undergoing LER. Future work is needed to examine the impact of improved glycemic control on clinical outcomes following LER.

title: Use of a XXXX management service improves glycemic control following vascular surgery: an interrupted time-series study.

answer: @entity3


abstract: This prospective epidemiological study of a population of hospital laboratory workers, exposed to @entity0 routinely, studied the prevalence of the presence of @entity2 antigen and antibody (HBsAg and HBsAb, respectively) over a 26-month period among these workers. Tests of liver functions, including measurement of serum @entity3 , were also performed. 111 were studied once and 199 employees were measured at least 2 times. Though the prevalence of antigen for @entity0 was 1.7% and that for antibody was 23.9%, the rate of @entity0 attack was only 3% per year, a percentage consistent with the expected sporadic occurrence of @entity4 in such a population. Attempts were made to isolate risk factors. The following were determined: 1) exposure to body fluids, 2) exposure to body tissue, and 3) increasing duration of employment. Sex was not found to be a significant difference. When information on prior transfusion or attack of @entity0 was elicited from the study population, those with 1 or the other showed a much higher prevalence of Hb marker; this prevalence of marker @entity0 had occurred in the past. However, the clinical significance of a positive HB marker with or without other risk factors (including @entity1 ingestion and use of oral contraceptives) was negligible. It was found that the prevalence figures of @entity0 antibody underestimate the incidence of @entity0 . Liver function tests were routinely normal in all cases (i.e., with or without previous @entity0 or presence of antibody or marker) except where @entity0 was present. The spread of @entity0 among laboratory personnel is not considered a great public health hazard.

title: XXXX antigen and antibody and tests of liver function: a prospective study of 310 hospital laboratory workers.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: Aqueductal @entity1 volume from phase-contrast MR imaging has been proposed for predicting shunt response in normal pressure @entity3 . However, this biomarker has remained controversial in use and has a lack of validation with invasive intracranial monitoring. We studied how @entity1 compares with intracranial pressure scores in the presurgical work-up and clinical score, ventricular volume, and aqueduct area and assessed the @entity0 's response to shunting. MATERIALS AND METHODS: Phase-contrast MR imaging was performed in 21 @entity0 with probable idiopathic normal pressure @entity3 . @entity0 were selected for shunting on the basis of pathologically @entity2 pulsatility. @entity0 with shunts were offered a second MR imaging after 12 months. Ventricular volume and transverse aqueductal area were calculated, as well as clinical symptom score. RESULTS: No correlations between @entity1 and preoperative scores of mean intracranial pressure or mean wave amplitudes were observed. Preoperative @entity1 was not different between @entity0 with shunts and conservatively treated @entity0 (P = .69) but was correlated with ventricular volume (R = 0.60, P = .004) and aqueductal area (R = 0.58, P = .006) but not with the severity or duration of clinical symptoms. After shunting, @entity1 (P = .006) and ventricular volume (P = .002) were reduced. A clinical improvement was seen in 16 of 17 @entity0 who had shunts (94%). CONCLUSIONS: Aqueductal @entity1 volume does not reflect intracranial pressure pulsatility or symptom score, but rather aqueduct area and ventricular volume. The results do not support the use of @entity1 for selecting @entity0 for shunting.

title: XXXX : Comparisons with Intracranial Pressure Scores in Idiopathic Normal Pressure Hydrocephalus.

answer: @entity1


abstract: PURPOSE: To evaluate the chondrogenic potential of platelet concentrates on @entity0 subchondral mesenchymal progenitor cells (MPCs) as assessed by histomorphometric analysis of proteoglycans and type II collagen. Furthermore, the migratory and proliferative effect of platelet concentrates were assessed. METHODS: Platelet-rich plasma (PRP) was prepared using preparation kits ( @entity1 [ @entity1 ] Kit [Arthrex, Naples, FL]; Regen ACR-C Kit [Regen Lab, Le Mont-Sur-Lausanne, Switzerland]; and Dr.PRP Kit [Rmedica, Seoul, Republic of Korea]) by apheresis (PRP-A) and by centrifugation ( @entity2 ). In contrast to clinical application, freeze-and-thaw cycles were subsequently performed to activate platelets and to prevent medium coagulation by residual fibrinogen in  vitro. MPCs were harvested from the cortico-spongious bone of femoral heads. Chondrogenic differentiation of MPCs was induced in high-density pellet cultures and evaluated by histochemical staining of typical cartilage matrix components. Migration of MPCs was assessed using a chemotaxis assay, and proliferation activity was measured by DNA content. RESULTS: MPCs cultured in the presence of 5% @entity1 , Regen, or Dr.PRP formed fibrous tissue, whereas MPCs stimulated with 5% PRP-A or @entity2 developed compact and dense cartilaginous tissue rich in type II collagen and proteoglycans. All platelet concentrates significantly ( @entity1 , P  = .00041; Regen, P  = .00029; Dr.PRP, P  = .00051; PRP-A, P < .0001; and @entity2 , P < .0001) stimulated migration of MPCs. All platelet concentrates but one (Dr.PRP, P  = .63) showed a proliferative effect on MPCs, as shown by significant increases ( @entity1 , P  = .027; Regen, P  = .0029; PRP-A, P  = .00021; and @entity2 , P  = .00069) in DNA content. CONCLUSIONS: Platelet concentrates obtained by different preparation methods exhibit different potentials to stimulate chondrogenic differentiation, migration, and proliferation of MPCs. Platelet concentrates obtained by commercially available preparation kits failed to induce chondrogenic differentiation of MPCs, whereas highly standardized PRP preparations did induce such differentiation. These findings suggest differing outcomes with PRP treatment in stem cell-based cartilage repair. CLINICAL RELEVANCE: Our findings may help to explain the variability of results in studies examining the use of PRP clinically.

title: Platelet-Rich Plasma Preparation Types Show Impact on Chondrogenic Differentiation, Migration, and Proliferation of XXXX Subchondral Mesenchymal Progenitor Cells.

answer: @entity0


abstract: BACKGROUND AND AIMS: Recognition of different genetic variants underlying development of @entity1 would make it possible to administer individual symptomatic treatment as well as early prophylactics of @entity1 . The aim of the study was to evaluate frequency of polymorphism 326A/T of gene @entity5 and assessment of its relations with the clinical parameters of osseous turnover and degree of @entity1 . METHODS: The study included 800 @entity0 at the postmenopausal (505) and reproductive (295) age throughout Wielkopolska region in Poland. The postmenopausal group included @entity0 with @entity1 and @entity3 and the healthy ones. @entity0 at the reproductive age were healthy. Frequency of the tested gene polymorphism was evaluated in the group where @entity2 was marked and in the control group. RESULTS: The analysis of the polymorphism @entity6 of gene @entity5 showed that in healthy postmenopausal female with genotype @entity4 birth weight, @entity2 L2-L4 YA (%) and @entity2 L2-L4 AM (%) were significantly higher ( @entity2 -bone mineral density; L2-L4-- lumbar vertebrae no 2, 4; YA--peak adult bone mass; AM--age-matched bone mass). In @entity0 with @entity2 L2-L4 YA (%) and @entity2 L2-L4 AM (%) were significantly higher in @entity0 with genotype @entity4 , but @entity2 L2-L4 was significantly higher in @entity0 with genotype TT. In @entity0 with @entity1 with genotype @entity4 T-score was significantly higher, but @entity2 L2-L4 and @entity2 L2-L4 YA (%) were significantly lower in this group. @entity2 L2-L4 AM (%) was significantly higher in @entity0 with @entity4 genotype. CONCLUSION: In @entity0 with @entity1 and @entity3 homozygous @entity4 genotype may predispose to lower @entity2 in the lumbar spine.

title: XXXX Polymorphism and its Relations to Bone Mineral Density in @entity0 .

answer: @entity5


abstract: BACKGROUND AND AIMS: Recognition of different genetic variants underlying development of @entity1 would make it possible to administer individual symptomatic treatment as well as early prophylactics of @entity1 . The aim of the study was to evaluate frequency of polymorphism 326A/T of gene @entity5 and assessment of its relations with the clinical parameters of osseous turnover and degree of @entity1 . METHODS: The study included 800 @entity0 at the postmenopausal (505) and reproductive (295) age throughout Wielkopolska region in Poland. The postmenopausal group included @entity0 with @entity1 and @entity3 and the healthy ones. @entity0 at the reproductive age were healthy. Frequency of the tested gene polymorphism was evaluated in the group where @entity2 was marked and in the control group. RESULTS: The analysis of the polymorphism @entity6 of gene @entity5 showed that in healthy postmenopausal female with genotype @entity4 birth weight, @entity2 L2-L4 YA (%) and @entity2 L2-L4 AM (%) were significantly higher ( @entity2 -bone mineral density; L2-L4-- lumbar vertebrae no 2, 4; YA--peak adult bone mass; AM--age-matched bone mass). In @entity0 with @entity2 L2-L4 YA (%) and @entity2 L2-L4 AM (%) were significantly higher in @entity0 with genotype @entity4 , but @entity2 L2-L4 was significantly higher in @entity0 with genotype TT. In @entity0 with @entity1 with genotype @entity4 T-score was significantly higher, but @entity2 L2-L4 and @entity2 L2-L4 YA (%) were significantly lower in this group. @entity2 L2-L4 AM (%) was significantly higher in @entity0 with @entity4 genotype. CONCLUSION: In @entity0 with @entity1 and @entity3 homozygous @entity4 genotype may predispose to lower @entity2 in the lumbar spine.

title: @entity5 Polymorphism and its Relations to Bone Mineral Density in XXXX .

answer: @entity0


abstract: PURPOSE: A head-to-head comparison of two clinical correlation models with a focus on geometrical accuracy for internal @entity2 motion estimation during real-time @entity2 tracking (RTTT). METHODS AND MATERIALS: Both the CyberKnife (CK) and the Vero systems perform RTTT with a correlation model that is able to describe hysteresis in the breathing motion. The CK dual-quadratic (DQ) model consists of two polynomial functions describing the trajectory of the @entity2 for inhale and exhale breathing motion, respectively. The Vero model is based on a two-dimensional (2D) function depending on position and speed of the external breathing signal to describe a closed-loop @entity2 trajectory. In this study, 20 s of internal motion data, using an 11 Hz (on average) full fluoroscopy (FF) sequence, was used for training of the CK and Vero models. Further, a subsampled set of 15 internal @entity2 positions (15p) equally spread over the different phases of the breathing motion was used for separate training of the CK DQ model. Also a linear model was trained using 15p and FF @entity2 motion data. Fifteen liver and @entity1 @entity0 , treated on the Vero system with RTTT, were retrospectively evaluated comparing the CK FF, CK 15p and Vero FF models using an in-house developed simulator. The distance between estimated target position and the @entity2 position localized by X-ray imaging was measured in the beams-eye view ( @entity3 ) to calculate the 95th percentile @entity3 modeling errors (ME(95, @entity3 )). Additionally, the percentage of ME(95, @entity3 ) smaller than 5 mm (P(5mm)) was determined for all correlation models. RESULTS: In general, no significant difference (p>0.05, paired t-test) was found between the CK FF and Vero models. Based on @entity0 -specific evaluation of the geometrical accuracy of the linear, CK DQ and Vero correlation models, no statistical necessity (p>0.05, two-way ANOVA) of including hysteresis in correlation models was proven, although during inhale breathing motion, the linear model resulted in a decreased P(5mm) with 5-6% compared to both the DQ CK and Vero models. CONCLUSION: Dual-quadratic CyberKnife and 2D Vero correlation models were interchangeable in terms of geometrical accuracy with the CK linear ME(95, @entity3 )=4.1 mm, CK dual-quadratic ME(95, @entity3 )=3.9 mm and Vero ME(95, @entity3 )=3.7 mm, when modeled with FF sequence. CK DQ modeling based on 15p acquired in 20 s may lead to problems for internal motion estimation.

title: A comparison of two clinical correlation models used for real-time XXXX tracking of semi-periodic motion: A focus on geometrical accuracy in lung and liver cancer @entity0 .

answer: @entity2


abstract: PURPOSE: A head-to-head comparison of two clinical correlation models with a focus on geometrical accuracy for internal @entity2 motion estimation during real-time @entity2 tracking (RTTT). METHODS AND MATERIALS: Both the CyberKnife (CK) and the Vero systems perform RTTT with a correlation model that is able to describe hysteresis in the breathing motion. The CK dual-quadratic (DQ) model consists of two polynomial functions describing the trajectory of the @entity2 for inhale and exhale breathing motion, respectively. The Vero model is based on a two-dimensional (2D) function depending on position and speed of the external breathing signal to describe a closed-loop @entity2 trajectory. In this study, 20 s of internal motion data, using an 11 Hz (on average) full fluoroscopy (FF) sequence, was used for training of the CK and Vero models. Further, a subsampled set of 15 internal @entity2 positions (15p) equally spread over the different phases of the breathing motion was used for separate training of the CK DQ model. Also a linear model was trained using 15p and FF @entity2 motion data. Fifteen liver and @entity1 @entity0 , treated on the Vero system with RTTT, were retrospectively evaluated comparing the CK FF, CK 15p and Vero FF models using an in-house developed simulator. The distance between estimated target position and the @entity2 position localized by X-ray imaging was measured in the beams-eye view ( @entity3 ) to calculate the 95th percentile @entity3 modeling errors (ME(95, @entity3 )). Additionally, the percentage of ME(95, @entity3 ) smaller than 5 mm (P(5mm)) was determined for all correlation models. RESULTS: In general, no significant difference (p>0.05, paired t-test) was found between the CK FF and Vero models. Based on @entity0 -specific evaluation of the geometrical accuracy of the linear, CK DQ and Vero correlation models, no statistical necessity (p>0.05, two-way ANOVA) of including hysteresis in correlation models was proven, although during inhale breathing motion, the linear model resulted in a decreased P(5mm) with 5-6% compared to both the DQ CK and Vero models. CONCLUSION: Dual-quadratic CyberKnife and 2D Vero correlation models were interchangeable in terms of geometrical accuracy with the CK linear ME(95, @entity3 )=4.1 mm, CK dual-quadratic ME(95, @entity3 )=3.9 mm and Vero ME(95, @entity3 )=3.7 mm, when modeled with FF sequence. CK DQ modeling based on 15p acquired in 20 s may lead to problems for internal motion estimation.

title: A comparison of two clinical correlation models used for real-time @entity2 tracking of semi-periodic motion: A focus on geometrical accuracy in lung and liver cancer XXXX .

answer: @entity0