abstract: BACKGROUND: In pediatric @entity0 , anterior cruciate ligament (ACL) reconstruction is controversial; however, delaying surgery until skeletal maturity is complete may increase the risk of secondary meniscal and articular @entity2 . PURPOSE: To assess the risk of meniscal and @entity1 with delay of ACL reconstruction. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Records were reviewed in @entity0 younger than 17 years (median age, 14 years) who had ACL reconstruction. @entity0 were consecutively enrolled and assigned to 1 of 3 surgical groups based on timing of surgery: acute (<6 weeks after surgery), subacute (6-12 weeks), or chronic (>3 months). The type and grade of @entity1 was documented according to the International Society of Arthroscopy, Knee Surgery, and Orthopaedic Sports Medicine (ISAKOS) meniscal classification criteria. International Cartilage Repair Society (ICRS) criteria were used to document location and grade of @entity1 . Associations between @entity0 characteristics and @entity1 were tested using rank sum and chi-square tests. Regression analyses were conducted to model incidence and severity of lateral and medial meniscal tears. There were 130 @entity0 who had 135 ACL reconstructions between the years of 2000 and 2012. RESULTS: Sixty-two @entity1 were treated acutely, 37 were subacute, and 36 were chronic. @entity1 (n = 112) included 70 lateral and 42 medial tears. Time to surgery had bivariate association with lateral and medial meniscal tears (P = .016 and .007, respectively). Independent risk factors for incidence of lateral meniscal tears were younger age (P = .028) and return to sports activities before surgery (P = .007). @entity0 with 1 episode of instability had 3-fold higher odds of higher grade lateral meniscal tear (95% CI, 1.30-7.60). Compared with acute reconstruction, subacute and chronic reconstruction @entity0 had 1.45 and 2.82 times higher odds, respectively, of lateral meniscal tear severity (P = .12). Independent risk factors for incidence of medial meniscal tears were female sex (P = .03), older age (P = .01), and any episode of instability (P = .01). Adjusted odds ratio for medial meniscal tear was 4.7 for an instability episode (vs no episode; P = .01). Adjusted odds ratio for increased severity of medial meniscal tears included any instability episode, 5.6 (P < .01); playing sports before reconstruction, 15.2 (P < .01); and time to surgery greater than 3 months, 4.3 (P = .046). Seventeen @entity0 had 23 @entity1 . The risk factors for @entity1 included increased time to surgery (P = .005) and any instability episode (P = .001). For increased grade of @entity1 , risk factors were time to surgery (P  <= .001) and any instability episode (P = .003). CONCLUSION: Delayed ACL reconstruction increased the risks of secondary meniscal and @entity1 in this population of pediatric @entity0 .

title: Correlation of Meniscal and Articular Cartilage Injuries in XXXX and Adolescents With Timing of Anterior Cruciate Ligament Reconstruction.

answer: @entity0


abstract: UNASSIGNED: @entity10 @ @entity5 magnetic nanoparticles modified by grafting @entity11 oligomer (FSPV) was fabricated as a novel adsorbent to remove Hg(II) from water. Fourier transform infra-red spectroscopy confirmed the successful grafting of oligomer, and thermogravimetric analysis showed FSPV had a high grafting yield with organic content of 22.8%. Transmission electron microscopy image displayed that FSPV particles were polymer-coated spheres with size of 10-20  nm. With saturation magnetization of 44.7 @entity7 /g, FSPV particles could be easily separated from water with a simple magnetic process in 5  min. The Hg(II) adsorption capacity of FSPV was found to be 346  mg/g at pH 7 and 25    C in 10  mM @entity3 . Moreover, the removal of Hg(II) by FSPV was not obviously affected by solution pH (from 4 to 10) or humic acid (up to 8  mg/L as TOC). The presence of seven common ions including Na(+), K(+), @entity0 , @entity2 , Cl(-), @entity9 , and @entity1 (up to 100  mM ionic strength) slightly increased the adsorption of Hg(II) by FSPV. X-ray photoelectron spectroscopy analysis revealed that the N atom of the @entity8 ring was responsible for the bonding with Hg(II), whereas the bonding of Hg with N did not result in cleavage of Hg-Cl bond in @entity4 and HgClOH. The regeneration of Hg(II)-loaded FSPV could be achieved with 0.5  M @entity6 rapidly in 10  min, and the removal of Hg(II) maintained above 94% in five consecutive adsorption-desorption cycles. Therefore, FSPV could serve as a promising adsorbent for Hg(II) removal from water.

title: Removal of Hg(II) by @entity11 -grafted XXXX @ @entity5 magnetic nanoparticles.

answer: @entity10


abstract: UNASSIGNED: @entity10 @ @entity5 magnetic nanoparticles modified by grafting @entity11 oligomer (FSPV) was fabricated as a novel adsorbent to remove Hg(II) from water. Fourier transform infra-red spectroscopy confirmed the successful grafting of oligomer, and thermogravimetric analysis showed FSPV had a high grafting yield with organic content of 22.8%. Transmission electron microscopy image displayed that FSPV particles were polymer-coated spheres with size of 10-20  nm. With saturation magnetization of 44.7 @entity7 /g, FSPV particles could be easily separated from water with a simple magnetic process in 5  min. The Hg(II) adsorption capacity of FSPV was found to be 346  mg/g at pH 7 and 25    C in 10  mM @entity3 . Moreover, the removal of Hg(II) by FSPV was not obviously affected by solution pH (from 4 to 10) or humic acid (up to 8  mg/L as TOC). The presence of seven common ions including Na(+), K(+), @entity0 , @entity2 , Cl(-), @entity9 , and @entity1 (up to 100  mM ionic strength) slightly increased the adsorption of Hg(II) by FSPV. X-ray photoelectron spectroscopy analysis revealed that the N atom of the @entity8 ring was responsible for the bonding with Hg(II), whereas the bonding of Hg with N did not result in cleavage of Hg-Cl bond in @entity4 and HgClOH. The regeneration of Hg(II)-loaded FSPV could be achieved with 0.5  M @entity6 rapidly in 10  min, and the removal of Hg(II) maintained above 94% in five consecutive adsorption-desorption cycles. Therefore, FSPV could serve as a promising adsorbent for Hg(II) removal from water.

title: Removal of Hg(II) by @entity11 -grafted @entity10 @ XXXX magnetic nanoparticles.

answer: @entity5


abstract: UNASSIGNED: @entity10 @ @entity5 magnetic nanoparticles modified by grafting @entity11 oligomer (FSPV) was fabricated as a novel adsorbent to remove Hg(II) from water. Fourier transform infra-red spectroscopy confirmed the successful grafting of oligomer, and thermogravimetric analysis showed FSPV had a high grafting yield with organic content of 22.8%. Transmission electron microscopy image displayed that FSPV particles were polymer-coated spheres with size of 10-20  nm. With saturation magnetization of 44.7 @entity7 /g, FSPV particles could be easily separated from water with a simple magnetic process in 5  min. The Hg(II) adsorption capacity of FSPV was found to be 346  mg/g at pH 7 and 25    C in 10  mM @entity3 . Moreover, the removal of Hg(II) by FSPV was not obviously affected by solution pH (from 4 to 10) or humic acid (up to 8  mg/L as TOC). The presence of seven common ions including Na(+), K(+), @entity0 , @entity2 , Cl(-), @entity9 , and @entity1 (up to 100  mM ionic strength) slightly increased the adsorption of Hg(II) by FSPV. X-ray photoelectron spectroscopy analysis revealed that the N atom of the @entity8 ring was responsible for the bonding with Hg(II), whereas the bonding of Hg with N did not result in cleavage of Hg-Cl bond in @entity4 and HgClOH. The regeneration of Hg(II)-loaded FSPV could be achieved with 0.5  M @entity6 rapidly in 10  min, and the removal of Hg(II) maintained above 94% in five consecutive adsorption-desorption cycles. Therefore, FSPV could serve as a promising adsorbent for Hg(II) removal from water.

title: Removal of Hg(II) by XXXX -grafted @entity10 @ @entity5 magnetic nanoparticles.

answer: @entity11


abstract: BACKGROUND: Crossed cerebello-cerebral diaschisis (CCCD) conventionally refers to decreased resting cerebral activity caused by injury to the contralateral cerebellum. We investigated whether functional activation of a contralesional cerebral cortical region controlling a specific task is reduced during task performance in a @entity0 with a @entity2 . We also examined functional compensation by the corresponding ipsilesional cerebral cortex. It was hypothesized that dysfunction of the primary sensorimotor cortex ( @entity3 ) contralateral to the @entity2 would be detected together with a compensatory increase in neural activity of the ipsilesional @entity3 . To test these possibilities, we conducted non-invasive functional neuroimaging techniques for bilateral @entity3 during hand grasping, a task known to activate predominantly the @entity3 contralateral to the grasping hand. Activity in @entity3 during hand grasping was measured electrophysiologically by magnetoencephalography and hemodynamically by near-infrared spectroscopy in an adult with mild @entity5 associated with a large injury of the right cerebellum due to resection of a @entity1 in early childhood. RESULTS: During left hand grasping, increased neural activity was detected predominantly in the right @entity3 , the typical developmental pattern. In contrast, neural activity increased in the bilateral @entity3 with slight right-side dominance during right (ataxic) hand grasping. CONCLUSIONS: This study reported a case that implied functional CCCD and compensatory neural activity in the @entity3 during performance of a simple hand motor task in an adult with @entity2 and mild hemiataxia 24  years prior to the study without rehabilitative interventions. This suggests that @entity2 in early childhood may result in persistent functional abnormalities in the cerebrum into adulthood. Therapeutic treatments that target functional CCCD and interhemispheric compensation might be effective for treating @entity4 due to @entity2 .

title: Implied functional crossed cerebello-cerebral diaschisis and interhemispheric compensation during hand grasping more than 20  years after XXXX in early childhood.

answer: @entity2


abstract: PURPOSE: To assess the value of oral effervescent powder (EP) for evaluation of esophageal distension, and for detection and staging of @entity2 with contrast-enhanced CT. MATERIALS AND METHODS: 84 @entity0 without esophageal pathology and 52 @entity0 with histological confirmed diagnosis of @entity2 were included in this prospective IRB-approved study. Half of the @entity0 in both groups received EP prior to CT. Esophageal distension was assessed by planimetry of the inner (IA) and outer area (OA). Two blinded readers evaluated the datasets separately with regard to diagnosis of @entity2 (yes/no) and staging (T0-T4), if applicable. Distension results were compared (t-Test). In @entity0 with @entity1 sensitivity, specificity, NPV and @entity3 were calculated. CT staging results were compared to histopathology (Cohen-k). RESULTS: IA and IA/OA were significantly larger after EP as compared to the group without EP (p<0.05). Sensitivity, specificity, NPV and @entity3 for @entity1 detection @entity1 were as follows: 78%/78%, 98%/98%, 95%/95%, 87%/87% with EP; 60%/68%, 98%/98%, 94%/94%, 80%/83% without EP. Staging with EP was good (k=0.84/0.67) and moderate without EP (k=0.58/0.59). CONCLUSIONS: Administration of EP prior to CT results in good distension of the esophagus, and improves detection and staging of @entity2 , as compared to control studies without EP.

title: Value of oral effervescent powder administration for multidetector CT evaluation of XXXX .

answer: @entity2


abstract: UNASSIGNED: There is increasing emphasis on the use of biomarkers of adverse outcomes in safety assessment and translational research. We evaluated serum biomarkers and targeted metabolite profiles after exposure to pesticides ( @entity2 , @entity3 , @entity7 , @entity9 , @entity10 , @entity1 ) with different @entity6 . Adult male Long-Evans @entity0 were evaluated after single exposure to vehicle or one of two doses of each pesticide at the time of peak effect. The doses were selected to produce similar magnitude of behavioral effects across chemicals. Serum or plasma was analyzed using commercial cytokine/protein panels and targeted metabolomics. Additional studies of @entity1 used lower doses (lacking behavioral effects), singly or for 14days, and included additional markers of exposure and biological activity. Biomarker profiles varied in the number of altered analytes and patterns of change across pesticide classes, and discriminant analysis could separate treatment groups from control. Low doses of @entity1 produced greater effects when given for 14days compared to a single dose. Changes in thyroid hormones and relative amounts of @entity1 and its @entity8 metabolite also differed between the dosing regimens. Most cytokine changes reflected alterations in inflammatory responses, hormone levels, and products of phospholipid, @entity5 , and @entity4 metabolism. These findings demonstrate distinct blood-based analyte profiles across pesticide classes, dose levels, and exposure duration. These results show promise for detailed analyses of these biomarkers and their linkages to biological pathways.

title: Assessment of serum biomarkers in XXXX after exposure to pesticides of different chemical classes.

answer: @entity0


abstract: OBJECTIVE: To describe the extent to which adherence to Consolidated Standards of Reporting Trials (CONSORT) statement in @entity0 ( @entity0 ) in adult @entity1 ( @entity1 ) has improved over time. DATA SOURCES: MEDLINE, PsycINFO, and CINAHL databases were searched from inception to September  2013. STUDY SELECTION: Primary report of @entity0 in adult @entity1 . The quality of reporting on CONSORT checklist items was examined and compared over time. Study selection was conducted by 2 researchers independently. Any disagreements were solved by discussion. DATA EXTRACTION: Two reviewers independently conducted data extraction based on a set of structured data extraction forms. Data regarding the publication years, size, locations, participation centers, intervention types, intervention groups, and CONSORT checklist items were extracted from the including trials. DATA SYNTHESIS: Of 105 trials reviewed, 38.1%, 5.7%, and 32.4% investigated drugs, surgical procedures, and rehabilitations as the intervention of interest, respectively. Among reports published between the 2 periods 2002 and 2010 (n=51) and 2011 and September 2013 (n=16), the median sample sizes were 99 and 118; 39.2% and 37.5% of all reports detailed implementation of the randomization process; 60.8% and 43.8% provided information on the method of allocation concealment; 56.9% and 31.3% stated how blinding was achieved; 15.7% and 43.8% reported information regarding trial registration; and only 2.0% and 6.3% stated where the full trial protocol could be accessed, all respectively. CONCLUSIONS: Reporting of several important methodological aspects of @entity0 conducted in adult @entity1 populations improved over the years; however, the quality of reporting remains below an acceptable level. The small sample sizes suggest that many @entity0 are likely underpowered. Further improvement is recommended in designing and reporting @entity0 .

title: Randomized Controlled Trials in Adult XXXX : A Review of Compliance to CONSORT Statement.

answer: @entity1


abstract: Our experience with primary open reduction with rigid internal fixation of 50 open @entity1 is presented. Twenty-seven @entity0 had associated major @entity3 . Twenty @entity1 were articular and 26 involved 3rd-degree wounds. The infection rate of 4%. A system of staged sequential debridement and wound management is presented. The authors believe this system has contributed to the low infection rate. No secondary amputations occurred. Eighty-two per cent of the @entity0 had good functional results using Charnley's criteria. Fatal post-traumatic @entity2 did not occur. The authors feel that early definitive @entity1 care employing rigid fixation which avoids casts, and allows improved wound management and early mobilization of the @entity3 @entity0 , has decreased the cardiopulmonary and metabolic consequences commonly associated with @entity3 @entity0 care.

title: Primary open reduction and internal fixation of open XXXX .

answer: @entity1


abstract: UNASSIGNED: Each year in the United States, nearly 500,000 @entity0 a year are born prematurely. Babies born before 35 weeks gestation are often placed on ventilators and/or given supplemental @entity2 . This increase in @entity2 , while critical for survival, can cause long-term damage to lungs, retinas and brains. In particular, @entity3 causes apoptosis in neurons and alters glial activity. @entity5 ( @entity5 ) and @entity4 ( @entity4 ) are members of the neurotrophin family of proteins that function to promote the growth, differentiation and development of the nervous system. We hypothesized that @entity3 can alter the regulation of these genes and by doing so adversely affect the development of the brain. We predicted that @entity1 exposed to hyperoxic conditions would have differences in @entity5 and @entity4 mRNA expression and relative level of methylated promoter regions coinciding with differences in the relative levels of @entity6 and @entity7 mRNA expression. To test this hypothesis, newborn C57Bl/6 @entity1 and their littermates were placed in hyperoxic or normoxic conditions from postnatal day 7 to 12. There were significant decreases in @entity5 mRNA expression in the prefrontal cortex following @entity3 , but a significant increase in the isocortex. @entity4 mRNA expression was significantly increased in both the isocortex and prefrontal cortex following @entity3 . @entity6 mRNA expression was significantly decreased in the isocortex but significantly increased in the prefrontal following @entity3 . Together these data suggest that short-term exposure to hyperoxic conditions can affect the regulation and expression of @entity5 and @entity4 potentially leading to alterations in neural development.

title: Neonatal XXXX induces alterations in neurotrophin gene expression.

answer: @entity3


abstract: UNASSIGNED: Few studies have investigated the effects of interictal @entity1 discharges on the cardiac autonomic system. This study reports the case of a 37-year-old @entity0 with refractory generalised @entity1 , who recently reported an increase in frequency of nocturnal @entity2 , not responding to treatment. During the nocturnal video study, in non-rapid eye movements sleep, we recorded 106 generalised sharp- and polyspike-waves lasting for 3 to 7 seconds, associated with @entity5 and @entity4 , without behavioural changes and without increase in deltoid muscle activity. The @entity4 had a duration of between 3 and 8 seconds. In one case, a 7 second @entity4 was associated with a tonic-clonic generalised @entity2 . A 24-hour electrocardiographic study revealed a @entity5 and a Wenckebach @entity3 . Heart rate analysis at the time of the interictal @entity1 discharges revealed an abrupt increase in the RR interval, occurring simultaneously with the onset of interictal @entity1 discharges and followed by a return to values below baseline value. A cardiac pacemaker was installed with a reduction of @entity4 length during the interictal @entity1 discharges. Our findings indicate, for the first time, the role of interictal generalised discharges in EEG-related @entity4 and @entity5 . These data support the hypothesis that some @entity0 with @entity1 may be predisposed to disturbances of the autonomic cardiac system.

title: XXXX and @entity4 during generalised interictal EEG discharges.

answer: @entity5


abstract: UNASSIGNED: Few studies have investigated the effects of interictal @entity1 discharges on the cardiac autonomic system. This study reports the case of a 37-year-old @entity0 with refractory generalised @entity1 , who recently reported an increase in frequency of nocturnal @entity2 , not responding to treatment. During the nocturnal video study, in non-rapid eye movements sleep, we recorded 106 generalised sharp- and polyspike-waves lasting for 3 to 7 seconds, associated with @entity5 and @entity4 , without behavioural changes and without increase in deltoid muscle activity. The @entity4 had a duration of between 3 and 8 seconds. In one case, a 7 second @entity4 was associated with a tonic-clonic generalised @entity2 . A 24-hour electrocardiographic study revealed a @entity5 and a Wenckebach @entity3 . Heart rate analysis at the time of the interictal @entity1 discharges revealed an abrupt increase in the RR interval, occurring simultaneously with the onset of interictal @entity1 discharges and followed by a return to values below baseline value. A cardiac pacemaker was installed with a reduction of @entity4 length during the interictal @entity1 discharges. Our findings indicate, for the first time, the role of interictal generalised discharges in EEG-related @entity4 and @entity5 . These data support the hypothesis that some @entity0 with @entity1 may be predisposed to disturbances of the autonomic cardiac system.

title: @entity5 and XXXX during generalised interictal EEG discharges.

answer: @entity4


abstract: In 38 conscious @entity1 divided into seven groups, acute unilateral @entity3 was induced by 1 hour of @entity4 while the contralateral kidney remained intact. @entity0 was monitored up to 144 hours after @entity2 and revealed a typical course of @entity3 with oligoanuria persisting for more than 48 hours. Urinary osmolality and @entity7 concentration became plasma isotonic after release of @entity4 and approximated control values on day 6 after @entity2 . In nine @entity1 , the i.v. infusion of @entity9 before (6 microgram/min/100 g body wt) and after (12 microgram/min/100 g body wt) @entity4 protected the @entity2 kidney from oligoanuria with endogenous @entity6 clearance of 0.42 +/- 0.11 ml/min/g kidney wt 5 hours after @entity2 . Tubular absorption of @entity7 and water was at least partially preserved 36 hours after @entity2 when infusion of @entity9 was stopped. The loop diuretic significantly (P less than 0.01) increased total urinary @entity10 (PG) E2 excretion before and after @entity4 ; and 5 hours after @entity2 , @entity8 excretion from the @entity2 kidney significantly exceeded that from the intact kidney (P less than 0.05). @entity11 (1 mg/100 g body wt) administered in six animals markedly suppressed control @entity8 excretion (P less than 0.05) as well as the @entity9 -induced rise in urinary PG excretion before and after @entity2 but did not modify the protective effect of the diuretic in this experimental model. Inhibition of PG synthesis, however, reduced urinary flow rate and @entity7 and @entity5 excretion of the contralateral intact kidney and almost completely prevented its compensatory rise in @entity6 clearance. The results indicate that mechanisms other than the intrarenal prostaglandin system must be considered to mediate the protective effects of @entity9 in acute @entity3 .

title: @entity10 -independent protection by XXXX from oliguric @entity3 in conscious @entity1 .

answer: @entity9


abstract: In 38 conscious @entity1 divided into seven groups, acute unilateral @entity3 was induced by 1 hour of @entity4 while the contralateral kidney remained intact. @entity0 was monitored up to 144 hours after @entity2 and revealed a typical course of @entity3 with oligoanuria persisting for more than 48 hours. Urinary osmolality and @entity7 concentration became plasma isotonic after release of @entity4 and approximated control values on day 6 after @entity2 . In nine @entity1 , the i.v. infusion of @entity9 before (6 microgram/min/100 g body wt) and after (12 microgram/min/100 g body wt) @entity4 protected the @entity2 kidney from oligoanuria with endogenous @entity6 clearance of 0.42 +/- 0.11 ml/min/g kidney wt 5 hours after @entity2 . Tubular absorption of @entity7 and water was at least partially preserved 36 hours after @entity2 when infusion of @entity9 was stopped. The loop diuretic significantly (P less than 0.01) increased total urinary @entity10 (PG) E2 excretion before and after @entity4 ; and 5 hours after @entity2 , @entity8 excretion from the @entity2 kidney significantly exceeded that from the intact kidney (P less than 0.05). @entity11 (1 mg/100 g body wt) administered in six animals markedly suppressed control @entity8 excretion (P less than 0.05) as well as the @entity9 -induced rise in urinary PG excretion before and after @entity2 but did not modify the protective effect of the diuretic in this experimental model. Inhibition of PG synthesis, however, reduced urinary flow rate and @entity7 and @entity5 excretion of the contralateral intact kidney and almost completely prevented its compensatory rise in @entity6 clearance. The results indicate that mechanisms other than the intrarenal prostaglandin system must be considered to mediate the protective effects of @entity9 in acute @entity3 .

title: XXXX -independent protection by @entity9 from oliguric @entity3 in conscious @entity1 .

answer: @entity10


abstract: In 38 conscious @entity1 divided into seven groups, acute unilateral @entity3 was induced by 1 hour of @entity4 while the contralateral kidney remained intact. @entity0 was monitored up to 144 hours after @entity2 and revealed a typical course of @entity3 with oligoanuria persisting for more than 48 hours. Urinary osmolality and @entity7 concentration became plasma isotonic after release of @entity4 and approximated control values on day 6 after @entity2 . In nine @entity1 , the i.v. infusion of @entity9 before (6 microgram/min/100 g body wt) and after (12 microgram/min/100 g body wt) @entity4 protected the @entity2 kidney from oligoanuria with endogenous @entity6 clearance of 0.42 +/- 0.11 ml/min/g kidney wt 5 hours after @entity2 . Tubular absorption of @entity7 and water was at least partially preserved 36 hours after @entity2 when infusion of @entity9 was stopped. The loop diuretic significantly (P less than 0.01) increased total urinary @entity10 (PG) E2 excretion before and after @entity4 ; and 5 hours after @entity2 , @entity8 excretion from the @entity2 kidney significantly exceeded that from the intact kidney (P less than 0.05). @entity11 (1 mg/100 g body wt) administered in six animals markedly suppressed control @entity8 excretion (P less than 0.05) as well as the @entity9 -induced rise in urinary PG excretion before and after @entity2 but did not modify the protective effect of the diuretic in this experimental model. Inhibition of PG synthesis, however, reduced urinary flow rate and @entity7 and @entity5 excretion of the contralateral intact kidney and almost completely prevented its compensatory rise in @entity6 clearance. The results indicate that mechanisms other than the intrarenal prostaglandin system must be considered to mediate the protective effects of @entity9 in acute @entity3 .

title: @entity10 -independent protection by @entity9 from oliguric XXXX in conscious @entity1 .

answer: @entity3


abstract: In 38 conscious @entity1 divided into seven groups, acute unilateral @entity3 was induced by 1 hour of @entity4 while the contralateral kidney remained intact. @entity0 was monitored up to 144 hours after @entity2 and revealed a typical course of @entity3 with oligoanuria persisting for more than 48 hours. Urinary osmolality and @entity7 concentration became plasma isotonic after release of @entity4 and approximated control values on day 6 after @entity2 . In nine @entity1 , the i.v. infusion of @entity9 before (6 microgram/min/100 g body wt) and after (12 microgram/min/100 g body wt) @entity4 protected the @entity2 kidney from oligoanuria with endogenous @entity6 clearance of 0.42 +/- 0.11 ml/min/g kidney wt 5 hours after @entity2 . Tubular absorption of @entity7 and water was at least partially preserved 36 hours after @entity2 when infusion of @entity9 was stopped. The loop diuretic significantly (P less than 0.01) increased total urinary @entity10 (PG) E2 excretion before and after @entity4 ; and 5 hours after @entity2 , @entity8 excretion from the @entity2 kidney significantly exceeded that from the intact kidney (P less than 0.05). @entity11 (1 mg/100 g body wt) administered in six animals markedly suppressed control @entity8 excretion (P less than 0.05) as well as the @entity9 -induced rise in urinary PG excretion before and after @entity2 but did not modify the protective effect of the diuretic in this experimental model. Inhibition of PG synthesis, however, reduced urinary flow rate and @entity7 and @entity5 excretion of the contralateral intact kidney and almost completely prevented its compensatory rise in @entity6 clearance. The results indicate that mechanisms other than the intrarenal prostaglandin system must be considered to mediate the protective effects of @entity9 in acute @entity3 .

title: @entity10 -independent protection by @entity9 from oliguric @entity3 in conscious XXXX .

answer: @entity1


abstract: INTRODUCTION: @entity1 remains a major concern for @entity0 undergoing radical prostatectomy. Its prevalence can reach 20% in the late postoperative period. MATERIALS AND METHODS: This clinical study investigated the differences of a dynamic evaluation of the urethra and pelvic floor contraction using perineal ultrasound in @entity0 without prostate surgery and in @entity0 submitted to radical prostatectomy with and without stress @entity1 . Ninety two male @entity0 were included, which 70% of them underwent radical prostatectomy (RP) for more than one year. Thirty one @entity0 with clinically @entity1 were compared by two-dimensional (2D) perineal ultrasound to 34 @entity0 without @entity1 and to 27 @entity0 without surgery in two centers in Brazil. RESULTS: Our results showed that the continent group presented the urethral angle at rest significantly lower than the prostate group (p = 0.0002). We also observed that the incontinent group showed the displacement of the anterior bladder neck during contraction significantly lower than the continent group (p = 0.008). CONCLUSIONS: We found that the continent group presented the urethral angle at rest significantly lower than the prostate group. The incontinent group also showed the anterior bladder neck displacement during contraction significantly lower than the continent group. It was more evident when the severe incontinent group and the continent group were compared.

title: Parameters of two-dimensional perineal ultrasonography for evaluation of XXXX after Radical Prostatectomy.

answer: @entity1


abstract: UNASSIGNED: Eutectic Mixture of Local Anaesthetics (EMLA) is recommended for use off-label as a treatment for @entity4 ( @entity4 ). Other topical anaesthetics are available, some of which have been evaluated against oral treatments. The purpose of this systematic review was to evaluate the evidence from @entity1 ( @entity1 ) for topical anaesthetics in the management of @entity4 . Bibliographic databases including MEDLINE were searched to August 2014. The primary outcome was intra-vaginal ejaculatory latency time (IELT). Methodological quality of @entity1 was assessed. IELT and other outcomes were pooled across @entity1 in a meta-analysis. Between-trial heterogeneity was assessed. Nine @entity1 were included. Seven were of unclear methodological quality. Pooled evidence (two @entity1 , 43 @entity0 ) suggests that EMLA is significantly more effective than placebo at increasing IELT (P < 0.00001). Individual RCT evidence also suggests that Topical Eutectic-like Mixture for @entity4 (TEMPE) spray and @entity5 gel are both significantly more effective than placebo (P = 0.003; P < 0.00001); and @entity5 gel is significantly more effective than @entity6 or @entity2 (P = 0.01; P = 0.0001). TEMPE spray is associated with significantly more adverse events than placebo (P = 0.003). More systemic adverse events are reported with @entity3 , @entity6 and @entity2 than with @entity5 gel. Diverse methods of assessing sexual satisfaction and ejaculatory control with topical anaesthetics are reported and evidence is conflicting. Topical anaesthetics appear more effective than placebo, @entity2 and @entity6 at increasing IELT in @entity0 with @entity4 . However, the methodological quality of the existing RCT evidence base is uncertain.

title: Topical anaesthetics for XXXX : a systematic review and meta-analysis.

answer: @entity4


abstract: OBJECTIVE: The @entity0 Health Questionnaire-15 (PHQ-15) is a frequently used questionnaire to assess somatic symptom burden. Recently, the Somatic Symptom Scale-8 (SSS-8) has been published as a short version of the PHQ-15. This study examines whether the instruments' psychometric properties and estimates of symptom burden are comparable. METHODS: Psychosomatic outpatients (N=131) completed the PHQ-15, the SSS-8 and other questionnaires (PHQ-9, GAD-7, WI-7, SF-12). Item characteristics and measures of reliability, validity, and symptom severity were determined and compared. RESULTS: The reliabilities of the PHQ-15 and SSS-8 were a=0.80 and a=0.76, respectively and both scales were highly correlated (r=0.83). The item characteristics were comparable. Both instruments showed the same pattern of correlations with measures of @entity2 , @entity1 , health @entity1 and health-related quality of life (r=0.32 to 0.61). On both scales a 1-point increase was associated with a 3% increase in health care use. The percentile distributions of the PHQ-15 and the SSS-8 were similar. Using the same thresholds for somatic symptom severity (5, 10, and 15 points), both instruments identified nearly identical subgroups of @entity0 with respect to health related quality of life. CONCLUSION: The PHQ-15 and the SSS-8 showed similar reliability and validity but the comparability of severity classifications needs further evaluation in other populations. Until then we recommend the use of the previously established thresholds. Overall, the SSS-8 performed well as a short version of the PHQ-15 which makes it preferable for assessment in time restricted settings.

title: Assessing somatic symptom burden: A psychometric comparison of the XXXX Health Questionnaire-15 (PHQ-15) and the Somatic Symptom Scale-8 (SSS-8).

answer: @entity0


abstract: INTRODUCTION: Free-text fields in injury surveillance databases can provide detailed information beyond routinely coded data. Additional data, such as exposures and covariates can be identified from narrative text and used to conduct case-control studies. METHODS: To illustrate this, we developed a text-search algorithm to identify helmet status (worn, not worn, use unknown) in the U.S. National Electronic Injury Surveillance System (NEISS) narratives for bicycling and other sports injuries from 2005 to 2011. We calculated adjusted odds ratios (ORs) for @entity1 associated with helmet use, with non- @entity1 representing controls. For bicycling, we validated ORs against published estimates. ORs were calculated for other sports and we examined factors associated with helmet reporting. RESULTS: Of 105,614 bicycling injury narratives reviewed, 14.1% contained sufficient helmet information for use in the case-control study. The adjusted ORs for @entity1 associated with helmet-wearing were smaller than, but directionally consistent, with previously published estimates (e.g., 1999 Cochrane Review). ORs illustrated a protective effect of helmets for other sports as well (less than 1). CONCLUSIONS: This exploratory analysis illustrates the potential utility of relatively simple text-search algorithms to identify additional variables in surveillance data. Limitations of this study include possible selection bias and the inability to identify individuals with @entity2 . A similar approach can be applied to study other injuries, conditions, risks, or protective factors. This approach may serve as an efficient method to extend the utility of @entity0 to conduct epidemiological research.

title: Making the most of XXXX : using narrative text to identify exposure information in case-control studies.

answer: @entity0


abstract: AIMS: Myocardial perfusion and @entity1 scores obtained from @entity2 ( @entity2 ) have strong independent prognostic value in elderly individuals without known @entity4 ( @entity4 ). Herein we aimed to assess their independent diagnostic value and accuracy for @entity4 while considering different thresholds of @entity5 . METHODS: We estimated the @entity3 ( @entity3 ), summed stress score (SSS) and summed difference score (SDS) in 322 elderly individuals (mean age 72  7 years, 68% @entity0 ) who underwent coronary angiography following an @entity2 . Abnormal perfusion at stress was defined as an SSS greater than 3, and @entity1 as an SDS of at least 2, and further categorized as mild (2-4), moderate (5-7) or severe (>7). Multivariate logistic regressions were used to establish the independent diagnostic value and accuracy of @entity2 parameters. RESULTS: @entity4 was diagnosed in 182 individuals (56%). In multivariate analysis accounting for clinical variables associated with @entity4 including the Framingham risk score, both @entity3 [odds ratio (OR) 1.09, 95% confidence interval (CI) 1.01-1.18, P=0.03] and SSS (OR 1.10, 95% CI 1.04-1.16, P=0.0006) and SDS (OR 1.12, 95% CI 1.04-1.21, P=0.003) were independently associated with @entity4 . An SSS greater than 3 was also independently associated with @entity4 (OR 2.51, 95% CI 1.43-4.39, P=0.0013), whereas an SDS of 2 or greater was not (OR 1.62, 95% CI 0.89-2.93, P=0.12), but only when at least 5 (OR 2.31, 95% CI 1.32-4.03, P=0.003). The probability of @entity4 was proportional to the amount of @entity5 in those with an SSS greater than 3, and lower and comparable in those with an SSS of at least 3 or an SSS greater than 3 with SDS of 1 or less (P=0.19). Increasing the threshold of @entity5 determined a decrease in sensitivity and increase in specificity of @entity2 for both diagnosis and severity of @entity4 . CONCLUSION: We established the diagnostic value and accuracy of continuous scores and thresholds of abnormal myocardial perfusion and @entity1 previously validated in prognostic studies. Their more widespread use could potentially improve the diagnostic yield of coronary angiography in elderly individuals with suspected @entity4 .

title: Diagnostic value of XXXX severity at myocardial perfusion imaging in elderly @entity0 with suspected coronary disease.

answer: @entity1


abstract: AIMS: Myocardial perfusion and @entity1 scores obtained from @entity2 ( @entity2 ) have strong independent prognostic value in elderly individuals without known @entity4 ( @entity4 ). Herein we aimed to assess their independent diagnostic value and accuracy for @entity4 while considering different thresholds of @entity5 . METHODS: We estimated the @entity3 ( @entity3 ), summed stress score (SSS) and summed difference score (SDS) in 322 elderly individuals (mean age 72  7 years, 68% @entity0 ) who underwent coronary angiography following an @entity2 . Abnormal perfusion at stress was defined as an SSS greater than 3, and @entity1 as an SDS of at least 2, and further categorized as mild (2-4), moderate (5-7) or severe (>7). Multivariate logistic regressions were used to establish the independent diagnostic value and accuracy of @entity2 parameters. RESULTS: @entity4 was diagnosed in 182 individuals (56%). In multivariate analysis accounting for clinical variables associated with @entity4 including the Framingham risk score, both @entity3 [odds ratio (OR) 1.09, 95% confidence interval (CI) 1.01-1.18, P=0.03] and SSS (OR 1.10, 95% CI 1.04-1.16, P=0.0006) and SDS (OR 1.12, 95% CI 1.04-1.21, P=0.003) were independently associated with @entity4 . An SSS greater than 3 was also independently associated with @entity4 (OR 2.51, 95% CI 1.43-4.39, P=0.0013), whereas an SDS of 2 or greater was not (OR 1.62, 95% CI 0.89-2.93, P=0.12), but only when at least 5 (OR 2.31, 95% CI 1.32-4.03, P=0.003). The probability of @entity4 was proportional to the amount of @entity5 in those with an SSS greater than 3, and lower and comparable in those with an SSS of at least 3 or an SSS greater than 3 with SDS of 1 or less (P=0.19). Increasing the threshold of @entity5 determined a decrease in sensitivity and increase in specificity of @entity2 for both diagnosis and severity of @entity4 . CONCLUSION: We established the diagnostic value and accuracy of continuous scores and thresholds of abnormal myocardial perfusion and @entity1 previously validated in prognostic studies. Their more widespread use could potentially improve the diagnostic yield of coronary angiography in elderly individuals with suspected @entity4 .

title: Diagnostic value of @entity1 severity at myocardial perfusion imaging in elderly XXXX with suspected coronary disease.

answer: @entity0


abstract: UNASSIGNED: The increased awareness of the potential role played by @entity4 in the appearance of @entity2 in renal @entity0 has produced research efforts aimed at discovering possible pathogenic links. Accordingly, the diagnostic significance of the classic bone markers of @entity3 and of the new markers in the setting of @entity7 ( @entity7 ) needs to be re-evaluated along with increasing information. In this article we include @entity11 and some of the noncollagenous bone proteins that are gaining experimental and clinical significance in @entity7 . Among classic markers of @entity12 and of @entity1 , we analyzed @entity6 , alkaline phosphatase, @entity13 -resistant acid phosphatase, and bone collagen-derived peptides. We underlined, for each, the relevance of parent proteins (peptides or isoforms) that affect assay methods and, eventually, the diagnostic or prognostic significance. Also, we considered their relationship with @entity2 . Among the numerous noncollagenous bone proteins, we examined @entity14 ( @entity14 ), osteocalcin (OC), @entity9 , and the small integrin-binding ligand N-linked glycoprotein family. For @entity14 and OC we report the relevant involvement with the process of calcification ( @entity14 ) and with @entity5 and energy metabolism (OC). Both of these proteins require @entity8 to become active and this is a specific problem in renal @entity0 who frequently are deficient of this @entity10 . Finally, recent acquisitions on the fascinating family of the small integrin-binding ligand N-linked glycoprotein proteins are recapitulated briefly to underline their potential clinical interest and their complex involvement with all aspects of @entity7 . Their diagnostic role in clinical practice awaits further studies.

title: News on Biomarkers in XXXX .

answer: @entity7


abstract: @entity8 is a rare disease with unknown cause. It is characterized by marked @entity7 in the gastrointestinal tract. There are few reports that include detailed endoscopic findings of @entity8 in the small intestine. A 48-year-old @entity0 complaining of @entity3 was admitted to our hospital. A complete blood count showed @entity7 , and @entity4 showed @entity7 . Abdominal computed tomography indicated @entity2 , wall thickening of the small intestine, and @entity4 . Capsule endoscopy revealed @entity5 , @entity2 , @entity1 , and aperistalsis in the upper jejunum, together with circumferential @entity6 and @entity6 in the ileum. Double-balloon enteroscopy revealed a 10-cm segmental mucosal @entity1 and @entity5 in the ileum. In one segment, there were several circumferential @entity6 . These lesions included both small round @entity6 and large @entity6 with @entity1 . Histological examination revealed infiltration of eosinophils into biopsy specimens of the ileum. The @entity0 was diagnosed with @entity8 . The @entity0 recovered after rehydration therapy. After 9  months, capsule endoscopy revealed no @entity6 or @entity1 . In this report, we describe the findings of capsule endoscopy and double-balloon enteroscopy in a case of @entity8 .

title: Novel findings of capsule endoscopy and double-balloon enteroscopy in a case of XXXX .

answer: @entity8


abstract: INTRODUCTION: @entity3 ( @entity3 ) is associated with poor perinatal outcomes. Screening and prevention tools for @entity3 , such as uterine artery Doppler imaging and @entity2 , underperform in high-risk groups, compared with general antenatal populations. There is a paucity of sensitive screening tests for the early prediction of @entity3 in high-risk pregnancies. MATERIALS AND METHODS: This was a prospective observational study based in a dedicated antenatal @entity1 clinic at a tertiary UK hospital. We assessed maternal demographic and central hemodynamic variables as predictors for @entity3 in a group of @entity0 at high risk for @entity4 due to chronic @entity1 (n = 55) or a history of @entity1 in a previous pregnancy (n = 71). Outcome variables were birthweight z-score as well as development of @entity3 (defined as birthweight below the 5th or 3rd centile). Maternal hemodynamics were assessed using a noninvasive transthoracic bioreactance monitor ( @entity5 NICOM). RESULTS: The mean gestation at presentation was 13.6 (range: 8.5-19.5) weeks. Sixteen @entity0 delivered babies below the 5th centile. Ten of these were below the 3rd centile. Independent predictors of birthweight z-score were body surface area, peripheral vascular resistance and white ethnicity (R(2) = 0.26, p < 0.0001). Independent predictors of @entity3 were maternal height and cardiac output. The area under the receiver operator characteristic curve for prediction of @entity3 was 0.915 (95% CI 0.859-0.972) and 0.9079 (95% CI 0.823-0.990) for @entity3 below the 5th and 3rd centiles, respectively. CONCLUSION: In @entity0 with chronic @entity1 or a history of @entity1 in a previous pregnancy, maternal size and cardiac output at booking provide a sensitive screening tool for @entity3 .

title: Maternal demographics and hemodynamics for the prediction of fetal growth restriction at booking, in pregnancies at high risk for XXXX .

answer: @entity4


abstract: UNASSIGNED: Purpose To investigate the possibility of using @entity3 ( @entity4 )-enhanced molecular magnetic resonance (MR) imaging and optical imaging to identify the true margins of @entity1 . Materials and Methods The animal protocol was approved by the institutional animal care and use committee. Thirty-six @entity2 with @entity1 were randomized into six groups of six @entity2 . Five groups were euthanized 15, 30, 60, 120, and 240 minutes after intravenous administration of 6 mg/kg of @entity4 , while one group received only saline solution as a control group. After craniotomy, optical imaging and T1-weighted MR imaging were performed to identify the @entity0 margins. One-way analysis of variance was used to compare optical photon intensity and MR imaging signal-to-noise ratios. Histologic analysis was performed to confirm the intracellular uptake of @entity4 by @entity0 cells and to correlate the @entity0 margins delineated on both optical and MR images. Results Both optical imaging and T1-weighted MR imaging showed @entity0 margins. The highest optical photon intensity (2.6 * 10(8) photons per second per mm(2)    2.3 * 10(7); analysis of variance, P < .001) and MR signal-to-noise ratio (77.61    2.52; analysis of variance, P = .006) were reached at 15-30 minutes after administration of @entity4 , with continued @entity0 visibility at 2-4 hours. Examination with confocal microscopy allowed confirmation that the fluorescence of optical images and MR imaging T1 enhancement exclusively originated from @entity4 that accumulated in the cytoplasm of @entity0 cells. Conclusion @entity4 -enhanced optical and MR imaging can allow determination of @entity0 margins at the optimal time of 15-120 minutes after administration of @entity4 . Clinical application of these results may @entity1 in a hybrid surgical setting in which intraoperative optical and MR imaging are available. (  ) RSNA, 2015.

title: @entity1 : XXXX -enhanced Molecular MR Imaging and Optical Imaging for Potential Intraoperative Delineation of Tumor Margins.

answer: @entity3


abstract: UNASSIGNED: Purpose To investigate the possibility of using @entity3 ( @entity4 )-enhanced molecular magnetic resonance (MR) imaging and optical imaging to identify the true margins of @entity1 . Materials and Methods The animal protocol was approved by the institutional animal care and use committee. Thirty-six @entity2 with @entity1 were randomized into six groups of six @entity2 . Five groups were euthanized 15, 30, 60, 120, and 240 minutes after intravenous administration of 6 mg/kg of @entity4 , while one group received only saline solution as a control group. After craniotomy, optical imaging and T1-weighted MR imaging were performed to identify the @entity0 margins. One-way analysis of variance was used to compare optical photon intensity and MR imaging signal-to-noise ratios. Histologic analysis was performed to confirm the intracellular uptake of @entity4 by @entity0 cells and to correlate the @entity0 margins delineated on both optical and MR images. Results Both optical imaging and T1-weighted MR imaging showed @entity0 margins. The highest optical photon intensity (2.6 * 10(8) photons per second per mm(2)    2.3 * 10(7); analysis of variance, P < .001) and MR signal-to-noise ratio (77.61    2.52; analysis of variance, P = .006) were reached at 15-30 minutes after administration of @entity4 , with continued @entity0 visibility at 2-4 hours. Examination with confocal microscopy allowed confirmation that the fluorescence of optical images and MR imaging T1 enhancement exclusively originated from @entity4 that accumulated in the cytoplasm of @entity0 cells. Conclusion @entity4 -enhanced optical and MR imaging can allow determination of @entity0 margins at the optimal time of 15-120 minutes after administration of @entity4 . Clinical application of these results may @entity1 in a hybrid surgical setting in which intraoperative optical and MR imaging are available. (  ) RSNA, 2015.

title: XXXX : @entity3 -enhanced Molecular MR Imaging and Optical Imaging for Potential Intraoperative Delineation of Tumor Margins.

answer: @entity1


abstract: UNASSIGNED: Objective: The aim of the present study is to investigate the effect of Nissen fundoplication to the pacemaker cells of an intestinal system and the serotonin receptors on an ICC membrane. Methods: Sixteen adult male @entity0 were taken into study. @entity0 were divided in to the following two groups. Nissen fundoplication was performed to study group (Group 1) and no surgical procedures were applied to control group (group 2). The @entity0 who were subjected to surgery and the @entity0 without surgery were sacrificed on to postoperative 14 days. Specimens for the pathologic analysis were obtained from upper esophagus (group A) and esophagogastric junction (EGJ) (group B). Distribution of ICC and @entity2 were evaluated separately. Results: There was a significant difference (p  =  0.01, p  =  0.02, respectively) regarding number of cells stained with CD117 between the group 1B-2B and group 2A-2B. Also there was a significant difference between (p  =  0.01, p  =  0.01 respectively) number of cells stained with @entity2 in groups 1A-1B and 2A-2B. However, no correlation was detected between group 1B-2B for @entity2 . Conclusion: A reduction in the number of ICC was observed in esophagogastric junctions of the fundoplication group but @entity2 distribution did not show a significant difference. A decrease in the number of ICC may be effective at postfundoplication @entity1 .

title: Evaluation of the relation between interstitial cells of cajal (CD117) and serotonin receptor ( @entity2 ) with postfundoplication XXXX .

answer: @entity1


abstract: UNASSIGNED: Objective: The aim of the present study is to investigate the effect of Nissen fundoplication to the pacemaker cells of an intestinal system and the serotonin receptors on an ICC membrane. Methods: Sixteen adult male @entity0 were taken into study. @entity0 were divided in to the following two groups. Nissen fundoplication was performed to study group (Group 1) and no surgical procedures were applied to control group (group 2). The @entity0 who were subjected to surgery and the @entity0 without surgery were sacrificed on to postoperative 14 days. Specimens for the pathologic analysis were obtained from upper esophagus (group A) and esophagogastric junction (EGJ) (group B). Distribution of ICC and @entity2 were evaluated separately. Results: There was a significant difference (p  =  0.01, p  =  0.02, respectively) regarding number of cells stained with CD117 between the group 1B-2B and group 2A-2B. Also there was a significant difference between (p  =  0.01, p  =  0.01 respectively) number of cells stained with @entity2 in groups 1A-1B and 2A-2B. However, no correlation was detected between group 1B-2B for @entity2 . Conclusion: A reduction in the number of ICC was observed in esophagogastric junctions of the fundoplication group but @entity2 distribution did not show a significant difference. A decrease in the number of ICC may be effective at postfundoplication @entity1 .

title: Evaluation of the relation between interstitial cells of cajal (CD117) and serotonin receptor ( XXXX ) with postfundoplication @entity1 .

answer: @entity2


abstract: BACKGROUND: We previously reported that the peripheral regulatory T cells (pTregs) generated 'on-demand' in the retina were crucial to retinal immune privilege, and in vitro analysis of retinal dendritic cells (DC) showed they possessed antigen presenting cell (APC) activity that promoted development of the Tregs and effector T cells (Teffs). Here, we expanded these findings by examining whether locally generated, locally acting pTregs were protective against spontaneous @entity1 and @entity1 mediated by @entity6 ( @entity6 ). We also examined the APC capacity of retinal DC in vivo. METHODS: Transgenic (Tg) @entity0 expressing @entity5 ( @entity5 ) and/or green fluorescent protein (GFP) under control of the endogenous @entity2 promoter (GFP only in FG @entity0 , GFP and @entity5 in FDG @entity0 ) or the @entity4 promoter (GFP and @entity5 in CDG @entity0 ) were used in conjunction with Tg @entity0 expressing beta-galactosidase (bgal) as retinal neo-self antigen and bgal-specific TCR Tg @entity0 (BG2). Retinal T cell responses were assayed by flow cytometry and retinal @entity1 assessed by histological examination. RESULTS: Local depletion of the Tregs enhanced actively induced experimental autoimmune @entity3 to the highly expressed retinal self-antigen @entity6 in FDG @entity0 and spontaneous @entity1 in bgal-FDG-BG2 @entity0 , but not in @entity0 lacking autoreactive T cells or their target antigen in the retina. The presence of retinal bgal downregulated the generation of antigen-specific Teffs and pTregs within the retina in response to local bgal challenge. Retinal DC depletion prevented generation of Tregs and Teffs within retina after bgal injection. Microglia remaining after DC depletion did not make up for loss of DC-dependent antigen presentation. CONCLUSIONS: Our results suggest that local retinal Tregs protect against spontaneous organ-specific @entity1 and that T cell responses within the retina require the presence of local DC.

title: Retinal antigen-specific regulatory T cells protect against spontaneous and induced XXXX and require local dendritic cells.

answer: @entity1


abstract: UNASSIGNED: Data on treatments and specific outcomes of primary @entity1 ( @entity1 ) >= 10cm are limited. We here report the treatments and survival outcomes concerning a subgroup of primary @entity1 .Data of 83 consecutive @entity0 with primary @entity1 >= 10cm in a single institution were retrospectively collected. Fifty-eight @entity0 underwent surgery before @entity4 mesylate (IM) treatment (Group A), 10 underwent surgical resection following IM therapy (Group B), whereas 15 @entity0 took IM as drug therapy alone (Group C).The baseline clinical characteristics were similar among the 3 groups. However, a lower proportion in Group A had metastatic disease at the time of diagnosis or surgery compared with Groups B and C (8.6% vs 40.0% vs 40.0%, P<0.05). The median follow-up duration was 21.5 months. No statistically significant differences were observed on progression-free survival (PFS) among the groups. However, @entity0 in Group B showed significantly better @entity2 ( @entity2 ) compared with those in Group C (P=0.044). Multivariate analysis showed that @entity0 treated with adjuvant IM were associated with better PFS (hazard ratio [HR] 3.01; 95% confidence interval [CI] 1.13-7.97; P=0.027) and @entity2 (HR 29.11; 95% CI 3.32-125.36; P=0.004). The subgroup with mitotic count >10/50 @entity3 ( @entity3 ) showed worse PFS (HR 3.50; 95% CI 1.19-10.25; P=0.022) and @entity2 (HR 20.04; 95% CI 1.67-143.79; P=0.018) than that of mitotic count  <=5/50 @entity3 .Clinical treatment patterns for primary @entity1 are different, and the outcomes of different interventions vary. The optimal treatments for these subgroup of @entity0 still require further long-term investigation. Moreover, mitotic count and adjuvant IM are closely associated with PFS and @entity2 in @entity1 .

title: Treatment and Prognoses in XXXX With Primary Gastrointestinal Stromal Tumors >= 10cm: A Single-Institution Experience in China.

answer: @entity0


abstract: OBJECTIVE: The aim of the present study is to highlight the beneficial effects of yoga practice on bio-parameters, such as oxidative stress, antioxidant components, immune functions, and secretion of stress hormones, in healthy young @entity0 . STUDY DESIGN: This study was conducted on healthy volunteers recruited from among university students, who were divided into two groups: a control (no yoga intervention, n=13) group and a yoga (n=12) group. Yoga practice was with an instructor for 90 minutes once a week spread over 12 weeks, with recommendations to practice daily at home for 40 minutes with the help of a @entity3 . The yoga program consisted of yoga body poses (asanas), exercises involving awareness, @entity6 of breath (pranayama), and meditational practices. Whole blood samples were collected when the volunteers had fasted for 8 hours at 0 and 12 weeks. The oxidative stress/antioxidant components, immune-related cytokines, and stress hormones were evaluated in serum or plasma. RESULTS: Serum levels of @entity2 , @entity8 , and lipid @entity5 were significantly decreased by yoga practice (p<0.05 or p=0.01), whereas serum total @entity4 ( @entity7 ) contents, activities of @entity7 -peroxidase, and @entity7 -s-transferase were remarkably increased after yoga practice compared with the control group (p<0.05 or p=0.01). Yoga practice also significantly increased immune-related cytokines, such as interleukin-12, and interferon-y, in serum (p<0.05 or p=0.01). Yoga practice significantly reduced the plasma levels of adrenalin (p<0.05) and increased plasma levels of @entity1 compared with the control group (p<0.05). CONCLUSIONS: Regular yoga practice remarkably attenuated oxidative stress and improved antioxidant levels of the body. Moreover, yoga beneficially affected stress hormone releases as well as partially improved immune function.

title: Regular Yoga Practice Improves Antioxidant Status, Immune Function, and Stress Hormone Releases in Young Healthy XXXX : A Randomized, Double-Blind, Controlled Pilot Study.

answer: @entity0


abstract: Importance: @entity5 ( @entity5 ) has been reported to be associated with a general reduced risk of @entity2 . These studies were mainly carried out in Western populations and little was known about associations in East Asians. Objective: To analyze the association between @entity5 and risk of @entity2 . Design, Setting, and @entity0 : In this cohort study, the data were obtained from the Taiwan National Health Insurance Research Database, which contained information on approximately 24.7 million insured individuals. The cohort included individuals with newly diagnosed as having @entity5 between 2004 and 2010. An age- and sex-matched systematic random-sampling method was used for subject selection in the reference non- @entity5 cohort. Multivariate Cox proportional hazard regression analysis was used to determine the effects of @entity5 on the risks of @entity2 , as shown by hazard ratios (HRs) with 95% CIs. Main Outcomes and Measures: The Taiwan Population Census and National Cancer Registry Databases were used to identify @entity0 with @entity2 . The last follow-up date was December 31, 2012. Results: In 62   023 @entity0 with @entity5 , the HR for all subsequent @entity2 combined was 1.58 (95% CI, 1.50-1.65). Of the 19 types of @entity2 , @entity5 was not associated with @entity12 . Increased HRs were found in the remaining 16 @entity2 , including malignant @entity8 (HR, 3.42; 95% CI, 1.84-6.38), @entity10 (esophageal [HR, 1.81; 95% CI, 1.28-2.57], stomach [HR, 1.59; 95% CI, 1.30-1.94], colorectal [HR, 1.47; 95% CI, 1.31-1.65], liver [HR, 1.89; 95% CI, 1.67-2.14]; gallbladder [HR, 1.73; 95% CI, 1.16-2.57], and pancreas [HR, 1.48; 95% CI, 1.09-2.02]) (P   <   .05 for all comparisons), @entity1 (HR, 1.56; 95% CI, 1.38-1.76), some hormone-related @entity2 (uterine [HR, 1.83; 95% CI, 1.12-3.01], cervical [HR, 1.36; 95% CI, 1.05-1.76], and prostate [HR, 1.80; 95% CI, 1.52-2.13; P   <   .05 for all comparisons), @entity11 (kidney and @entity3 ; HRs, 1.59 and 1.99, respectively; P   <   .001 for both comparisons), @entity7 (HR, 1.62; 95% CI, 1.31-2.01), @entity6 (HR, 2.75; 95% CI, 1.35-5.59), and other @entity9 (HR, 1.81; 95% CI, 1.46-2.23). For @entity4 , the highest HR resided in the 50- to 59-year-old group (HR, 2.57; 95% CI, 1.7-3.89). Conclusions and Relevance: Our study concludes that @entity5 is is associated with most @entity2 in Taiwan. Further studies are needed to clarify whether our findings can be applied to other East Asian populations. The differences between our study and most previous cohorts suggest the importance of ethnicity and environmental exposures in disease pathogenesis.

title: Association Between XXXX and Risk of Cancer in Taiwan.

answer: @entity5


abstract: OBJECTIVE: The goal of this systematic review was to reach scientific generalizations regarding the assessment of risk for pressure @entity2 based on the results of previous studies that made use of the Braden Scale. DATA SOURCES: This research was performed by using a retrospective screening of studies relevant to the subject. In @entity1 , the first validity and reliability study for the Braden Scale was performed by O  uz and Olgun in 1998. For this reason, the authors' research was conducted between @entity3 , 2012, and August 4, 2012, as a systematic review analysis by evaluating studies in @entity1 that made use of the Braden Scale between 1998 and 2012. Screening was performed by using different combinations of 8 keywords in Turkish and English to scan a total of 10 national and international databases. A total of 2375 studies were evaluated, and 16 studies were included and considered within the context of this research. RESULTS AND CONCLUSIONS: It was determined that the studies considered within the context of the current research were conducted between 1998 and 2012; 5 of these studies were experimental and 11 were descriptive; the sample size varied between 22 and 422; the majority were performed in intensive care units; and the study samples were mostly composed of @entity0 . The Braden Scale was used in these studies for forming samples by identifying high-risk @entity0 . Two studies evaluated the reliability of the Braden Scale, whereas 7 other studies calculated the reliability coefficient. Only 1 study included results for sensitivity, specificity, positive predictive value, and negative predictive value (which represent the predictive criteria of assessment tools). Four studies indicated cutoff values, which varied between 14 and 18. A general evaluation of these studies' results revealed limited evidence of effective risk assessment by the Braden Scale.

title: The Use of the Braden Scale in Assessing Pressure Ulcers in XXXX : A Systematic Review.

answer: @entity1


abstract: UNASSIGNED: In this paper, we present a unified modeling framework to combine aggregated data from @entity2 ( @entity2 ) with individual @entity0 data (IPD) from observational studies. Rather than simply pooling the available evidence into an overall treatment effect, adjusted for potential confounding, the intention of this work is to explore treatment effects in specific @entity0 populations reflected by the IPD. In this way, by collecting IPD, we can potentially gain new insights from @entity2 ' results, which cannot be seen using only a meta-analysis of @entity2 . We present a new Bayesian hierarchical meta-regression model, which combines submodels, representing different types of data into a coherent analysis. Predictors of baseline risk are estimated from the individual data. Simultaneously, a bivariate random effects distribution of baseline risk and treatment effects is estimated from the combined individual and aggregate data. Therefore, given a subgroup of interest, the estimated treatment effect can be calculated through its correlation with baseline risk. We highlight different types of model parameters: those that are the focus of inference (e.g., treatment effect in a subgroup of @entity0 ) and those that are used to adjust for biases introduced by data collection processes (e.g., internal or external validity). The model is applied to a case study where @entity2 ' results, investigating efficacy in the treatment of @entity1 , are extrapolated to groups of @entity0 treated in medical routine and who were enrolled in a prospective cohort study. Copyright    2015 John Wiley _ Sons, Ltd.

title: Bayesian evidence synthesis for exploring generalizability of treatment effects: a case study of combining randomized and non-randomized results in XXXX .

answer: @entity1


abstract: Judged @entity1 and its justifiability were examined with caricature cartoons and films of @entity0 doing comparable things. Effects of viewer gender, interactant gender, and facial expression were examined. Facial expression strongly affected both types of judgment, viewer gender had no influence, and interactant gender contributed slightly. Real-cartoon differences were significant, but accounted for little variance. Major response patterns were similar for films of @entity0 and cartoons. In two developmental studies, only facial expression influenced judgments of friendliness-hostility in cartoons, but condemnation of @entity1 decreased as viewer age increased. Results with films of real @entity0 followed those for cartoons. Facial expression influenced judged @entity1 , but only viewer age affected judged justifiability. Cross-experiment comparisons revealed that facial expression and the facial expression X real-cartoon interaction yielded major differences on both dependent variables. Subject and interactant gender were not significant for major dependent variables. Results of the developmental studies were similar to adults' suggesting that for judgments of simple aggressive acts, sex makes no difference, but facial expression does make a difference.

title: Does sex make a difference? Gender, age, and stimulus realism in perception and evaluation of XXXX .

answer: @entity1


abstract: The @entity4 is an @entity3 found in long-distance runners. It is characterized by @entity2 on the outer aspect of the knee in close relation to the lateral femoral epicondyle. It is usually poorly localized, is aggravated by running long distances or excessive striding, and is more severe running downhill. It may be prevented by walking with a stiff knee. In a series of 100 consecutive knees, including 6 @entity0 with the syndrome in both knees (age range, 19 to 48 years; average, 31 years), of which 73 were available for follow-up evaluation, only 30 @entity0 were resolved on the initial regimen of a single injection of local @entity1 and reduction in the training program. Twenty-one @entity0 had two injections and 8 @entity0 required the third injection. The remaining 14 @entity0 were placed on a regimen of total rest from running for 4 to 6 weeks. Nine @entity0 returned to training and had no recurrence of @entity2 . Five @entity0 consented to surgery and returned to long-distance running between 2 and 7 weeks later. The syndrome apparently has a higher incidence in areas where long-distance running is the vogue, such as, South Africa, or where the climate is cool and running surfaces are slippery.

title: XXXX in runners.

answer: @entity4


abstract: OBJECTIVE: To determine the psychometric properties of the Neck Bournemouth Questionnaire in @entity0 with @entity1 , using Rasch analysis. METHODS: A sample of 161 subjects with @entity1 was assessed with the Neck Bournemouth Questionnaire. Before performing Rasch analysis, we examined the structure of the scale with factor analysis. The goodness-of-fit of the data to the model, thresholds ordering, unidimensionality, local independence of the items, differential item functioning, @entity0 separation index, and mean @entity0 's location were assessed. RESULTS: Both exploratory and confirmatory factor analyses supported the presence of 2 factors. Only Factor 1 needed a modification (item 7 removal) in order to achieve the fit to the Rasch model (  2   =   10.65, df 8, p   =   0.22). The @entity0 separation index was 0.80 and the mean location of @entity0 0.48 (standard deviation (SD) 1.02). @entity2 (items 4 and 5) fitted the model without modifications (  2   =   3.86, df 4, p   =   0.42). Its @entity0 separation index and mean @entity0 's location were, respectively, 0.77 and -0.71 (SD 1.57). CONCLUSION: The Neck Bournemouth Questionnaire with the purposed modification may provide useful clinical profiles and change scores of subjects with @entity1 for research purposes.

title: Rasch analysis of the Neck Bournemouth Questionnaire to measure disability related to XXXX .

answer: @entity1


abstract: BACKGROUND AND PURPOSE: @entity2 ( @entity2 ) are a group of rare @entity6 . The identification of specific antibodies directed to @entity4 ( @entity4 -IgG) led to the distinction from @entity1 . However, up to 25% of the clinically diagnosed NMO @entity0 are seronegative for @entity4 -IgG. A subgroup of these @entity0 might be identified by antibodies directed to @entity3 ( @entity3 -IgG). Our objective was to investigate whether the clinical characteristics of these @entity0 differ. METHODS: Using a cell-based assay, samples of 61 @entity4 -IgG seronegative @entity0 and 41 @entity4 -IgG seropositive @entity0 with clinically NMOSD were analysed for the presence of @entity3 -IgG. Clinical characteristics of the @entity4 -IgG, @entity3 -IgG seropositive and double seronegative NMOSD @entity0 were compared. RESULTS: Twenty of the 61 @entity4 -IgG seronegative @entity0 tested @entity3 -IgG seropositive (33%). @entity3 -IgG seropositive @entity0 were more frequently males in contrast to @entity4 -IgG seropositive @entity0 (55% vs. 15%, P < 0.01) and Caucasians (90% vs. 63%, P = 0.03). They more frequently presented with coincident @entity7 and transverse @entity5 (40% vs. 12%, P = 0.02) and had a monophasic disease course (70% vs. 29%, P < 0.01). @entity4 -IgG seropositive @entity0 were 2.4 times more likely to suffer from relapses compared with @entity3 -IgG seropositive @entity0 (relative risk 2.4, 95% confidence interval 1.2-4.7). @entity4 -IgG seropositive @entity0 had higher Expanded Disability Status Scale levels at last follow-up (P < 0.01). CONCLUSION: Antibodies directed to @entity3 identify a subgroup of @entity4 -IgG seronegative NMO @entity0 with generally a favourable monophasic disease course.

title: @entity2 : comparison of clinical and magnetic resonance imaging characteristics of XXXX -IgG versus @entity3 -IgG seropositive cases in the Netherlands.

answer: @entity4


abstract: BACKGROUND AND PURPOSE: @entity2 ( @entity2 ) are a group of rare @entity6 . The identification of specific antibodies directed to @entity4 ( @entity4 -IgG) led to the distinction from @entity1 . However, up to 25% of the clinically diagnosed NMO @entity0 are seronegative for @entity4 -IgG. A subgroup of these @entity0 might be identified by antibodies directed to @entity3 ( @entity3 -IgG). Our objective was to investigate whether the clinical characteristics of these @entity0 differ. METHODS: Using a cell-based assay, samples of 61 @entity4 -IgG seronegative @entity0 and 41 @entity4 -IgG seropositive @entity0 with clinically NMOSD were analysed for the presence of @entity3 -IgG. Clinical characteristics of the @entity4 -IgG, @entity3 -IgG seropositive and double seronegative NMOSD @entity0 were compared. RESULTS: Twenty of the 61 @entity4 -IgG seronegative @entity0 tested @entity3 -IgG seropositive (33%). @entity3 -IgG seropositive @entity0 were more frequently males in contrast to @entity4 -IgG seropositive @entity0 (55% vs. 15%, P < 0.01) and Caucasians (90% vs. 63%, P = 0.03). They more frequently presented with coincident @entity7 and transverse @entity5 (40% vs. 12%, P = 0.02) and had a monophasic disease course (70% vs. 29%, P < 0.01). @entity4 -IgG seropositive @entity0 were 2.4 times more likely to suffer from relapses compared with @entity3 -IgG seropositive @entity0 (relative risk 2.4, 95% confidence interval 1.2-4.7). @entity4 -IgG seropositive @entity0 had higher Expanded Disability Status Scale levels at last follow-up (P < 0.01). CONCLUSION: Antibodies directed to @entity3 identify a subgroup of @entity4 -IgG seronegative NMO @entity0 with generally a favourable monophasic disease course.

title: @entity2 : comparison of clinical and magnetic resonance imaging characteristics of @entity4 -IgG versus XXXX -IgG seropositive cases in the Netherlands.

answer: @entity3


abstract: BACKGROUND AND PURPOSE: @entity2 ( @entity2 ) are a group of rare @entity6 . The identification of specific antibodies directed to @entity4 ( @entity4 -IgG) led to the distinction from @entity1 . However, up to 25% of the clinically diagnosed NMO @entity0 are seronegative for @entity4 -IgG. A subgroup of these @entity0 might be identified by antibodies directed to @entity3 ( @entity3 -IgG). Our objective was to investigate whether the clinical characteristics of these @entity0 differ. METHODS: Using a cell-based assay, samples of 61 @entity4 -IgG seronegative @entity0 and 41 @entity4 -IgG seropositive @entity0 with clinically NMOSD were analysed for the presence of @entity3 -IgG. Clinical characteristics of the @entity4 -IgG, @entity3 -IgG seropositive and double seronegative NMOSD @entity0 were compared. RESULTS: Twenty of the 61 @entity4 -IgG seronegative @entity0 tested @entity3 -IgG seropositive (33%). @entity3 -IgG seropositive @entity0 were more frequently males in contrast to @entity4 -IgG seropositive @entity0 (55% vs. 15%, P < 0.01) and Caucasians (90% vs. 63%, P = 0.03). They more frequently presented with coincident @entity7 and transverse @entity5 (40% vs. 12%, P = 0.02) and had a monophasic disease course (70% vs. 29%, P < 0.01). @entity4 -IgG seropositive @entity0 were 2.4 times more likely to suffer from relapses compared with @entity3 -IgG seropositive @entity0 (relative risk 2.4, 95% confidence interval 1.2-4.7). @entity4 -IgG seropositive @entity0 had higher Expanded Disability Status Scale levels at last follow-up (P < 0.01). CONCLUSION: Antibodies directed to @entity3 identify a subgroup of @entity4 -IgG seronegative NMO @entity0 with generally a favourable monophasic disease course.

title: XXXX : comparison of clinical and magnetic resonance imaging characteristics of @entity4 -IgG versus @entity3 -IgG seropositive cases in the Netherlands.

answer: @entity2


abstract: INTRODUCTION: The treatment of massive @entity1 with an associated @entity2 is controversial; however, surgical thrombectomy with extracorporeal circulation (ECC) is an option for treatment. It is difficult to remove all @entity0 material. Theoretically, retrograde blood perfusion through the lungs may be beneficial. OBJECTIVES: To investigate whether retrograde blood perfusion through the lungs during a thrombectomy is beneficial. METHODS: Twelve @entity3 were prepared for ECC. Repetitive injections of preformed blood thrombi into the right atrium resulted in @entity2 . ECC was established after 10minutes of @entity2 , and after a sternotomy, the main pulmonary artery was incised and as much thrombotic material as possible was removed from the pulmonary arteries. The @entity3 were randomised to ECC for one hour either with or without retrograde perfusion in the pulmonary circulation. After one hour, the released material was removed from the pulmonary arteries, and the incision was sutured. The @entity3 were weaned from the ECC. After sacrificing the @entity3 , they were autopsied with special attention to the amount of remaining thrombi. Additional histological analyses were performed with special attention to microembolisms, atelectases, and signs of @entity4 . RESULTS: All of the @entity3 were weaned from the ECC. The amount of the embolic material removed varied considerably, as did the amount removed after the retrograde or antegrade perfusion, and there was no significant difference between the two treatment modalities. There were no signs of @entity4 in the lungs. CONCLUSIONS: Retrograde lung perfusion was not generally beneficial in the treatment of massive @entity1 in this setup; however, it may be an option if only a modest amount of material is accessible in the pulmonary artery.

title: Retrograde lung perfusion in the treatment of massive XXXX . A randomised porcine study.

answer: @entity1


abstract: Asphyxiating @entity5 is an uncommon condition with multiple organ afectation and high neonatal mortality. It presents with @entity4 , short extremities, narrow thorax. With growth, there is respiratory improvement, but emergence of @entity1 . OBJECTIVE: to describe the long-term evolution of 8 @entity0 of a pediatric hospital. METHODS: we retrospectively evaluated age at diagnosis, sex, anthropometric variables, complications and radiology. RESULTS: male/female 6/2. Median age at diagnosis: 2.54 years. EVOLUTION: 8/8 respiratory compromise, 3/8 kidney, liver 2/8, 1/8 ophthalmologic, cardiac 1/8. Median height at diagnosis -1.76 DS, normal postnatal growth and body proportions. Radiology: 8/8 narrow chest and brachyphalangia in hands. 5/8 acetabular abnormalities. DISCUSSION: for surveillance it is recommended to monitor @entity2 . The pediatrician should suspect this entity in a newborn with @entity3 .

title: [Clinical, radiological and auxologic long-term evolution of 8 @entity0 with asphyxiating XXXX ].

answer: @entity5


abstract: Asphyxiating @entity5 is an uncommon condition with multiple organ afectation and high neonatal mortality. It presents with @entity4 , short extremities, narrow thorax. With growth, there is respiratory improvement, but emergence of @entity1 . OBJECTIVE: to describe the long-term evolution of 8 @entity0 of a pediatric hospital. METHODS: we retrospectively evaluated age at diagnosis, sex, anthropometric variables, complications and radiology. RESULTS: male/female 6/2. Median age at diagnosis: 2.54 years. EVOLUTION: 8/8 respiratory compromise, 3/8 kidney, liver 2/8, 1/8 ophthalmologic, cardiac 1/8. Median height at diagnosis -1.76 DS, normal postnatal growth and body proportions. Radiology: 8/8 narrow chest and brachyphalangia in hands. 5/8 acetabular abnormalities. DISCUSSION: for surveillance it is recommended to monitor @entity2 . The pediatrician should suspect this entity in a newborn with @entity3 .

title: [Clinical, radiological and auxologic long-term evolution of 8 XXXX with asphyxiating @entity5 ].

answer: @entity0


abstract: BACKGROUND: Vaccination against @entity6 is recommended in @entity0 with @entity4 ( @entity4 ). However, so far, no systematic review has summarized the available evidence on the effectiveness and safety of @entity6 vaccination in this @entity0 group. METHODS: We conducted a systematic review and meta-analysis and assessed the quality of evidence using the GRADE methodology. We searched MEDLINE, EMBASE, Cochrane Library databases, ClinicalTrials.gov, and reference lists for studies on efficacy, effectiveness, and/or safety of seasonal @entity6 vaccination in @entity0 with @entity4 receiving dialysis. All reported clinical outcomes were considered, including all-cause mortality, @entity2 , @entity2 , all-cause hospitalization, hospitalization due to @entity1 , hospitalization due to @entity9 , @entity5 , or @entity3 , hospitalization due to @entity8 , ICU admission, and @entity6 . RESULTS: Five observational studies and no randomized-controlled trial were identified. In four studies, risk of bias was high regarding all reported outcomes. Strong residual confounding was likely to be present in one study reporting on three outcomes, as indicated by significant protective effects of vaccination outside @entity6 seasons. Therefore, the statistically significant protective effects on all-cause mortality ( @entity10 ( @entity10 ), 32%; 95% CI, 24-39%), @entity2 ( @entity10 , 16%; 95% CI, 1-29%), hospitalization due to @entity1 ( @entity10 , 14%; 95% CI, 7-20%), ICU admission ( @entity10 , 81%; 95% CI, 63-86%), and @entity6 ( @entity10 , 12%; 95% CI, 10-14%) have to be taken with caution. According to GRADE, the quality of the body of evidence was considered very low for all outcomes. No study reported on laboratory-confirmed @entity7 or on safety endpoints. CONCLUSIONS: Evidence on the protective effects of @entity6 vaccination in @entity0 with @entity4 is limited and of very low quality. Since @entity10 estimates in the available literature are prone to unmeasured confounding, studies using randomization or quasi-experimental designs are needed to determine the extent by which vaccination prevents @entity6 and related clinical outcomes in this at-risk population. However, given the high rates of health-endangering events in these @entity0 , even a low @entity10 can be considered as sufficient to recommend annual @entity6 vaccination.

title: Influenza vaccination in @entity0 with XXXX : systematic review and assessment of quality of evidence related to vaccine efficacy, effectiveness, and safety.

answer: @entity4


abstract: BACKGROUND: Vaccination against @entity6 is recommended in @entity0 with @entity4 ( @entity4 ). However, so far, no systematic review has summarized the available evidence on the effectiveness and safety of @entity6 vaccination in this @entity0 group. METHODS: We conducted a systematic review and meta-analysis and assessed the quality of evidence using the GRADE methodology. We searched MEDLINE, EMBASE, Cochrane Library databases, ClinicalTrials.gov, and reference lists for studies on efficacy, effectiveness, and/or safety of seasonal @entity6 vaccination in @entity0 with @entity4 receiving dialysis. All reported clinical outcomes were considered, including all-cause mortality, @entity2 , @entity2 , all-cause hospitalization, hospitalization due to @entity1 , hospitalization due to @entity9 , @entity5 , or @entity3 , hospitalization due to @entity8 , ICU admission, and @entity6 . RESULTS: Five observational studies and no randomized-controlled trial were identified. In four studies, risk of bias was high regarding all reported outcomes. Strong residual confounding was likely to be present in one study reporting on three outcomes, as indicated by significant protective effects of vaccination outside @entity6 seasons. Therefore, the statistically significant protective effects on all-cause mortality ( @entity10 ( @entity10 ), 32%; 95% CI, 24-39%), @entity2 ( @entity10 , 16%; 95% CI, 1-29%), hospitalization due to @entity1 ( @entity10 , 14%; 95% CI, 7-20%), ICU admission ( @entity10 , 81%; 95% CI, 63-86%), and @entity6 ( @entity10 , 12%; 95% CI, 10-14%) have to be taken with caution. According to GRADE, the quality of the body of evidence was considered very low for all outcomes. No study reported on laboratory-confirmed @entity7 or on safety endpoints. CONCLUSIONS: Evidence on the protective effects of @entity6 vaccination in @entity0 with @entity4 is limited and of very low quality. Since @entity10 estimates in the available literature are prone to unmeasured confounding, studies using randomization or quasi-experimental designs are needed to determine the extent by which vaccination prevents @entity6 and related clinical outcomes in this at-risk population. However, given the high rates of health-endangering events in these @entity0 , even a low @entity10 can be considered as sufficient to recommend annual @entity6 vaccination.

title: Influenza vaccination in XXXX with @entity4 : systematic review and assessment of quality of evidence related to vaccine efficacy, effectiveness, and safety.

answer: @entity0


abstract: BACKGROUND: The study aim was to determine the association between @entity0 's objectively assessed moderate-to-vigorous physical activity (MVPA) and @entity1 ( @entity1 ) and independently mobile trips (IM) during out-of-school hours. METHODS: @entity0 aged 9 to 13 years (n = 254) were recruited from 9 schools in Auckland, New Zealand between 2011 and 2012. @entity0 completed travel diaries and wore accelerometers for 7 days. Parents provided demographic information. Geographic information systems-derived distance to school was calculated. Accelerometer data were extracted for out of school hours only. Percentage of time spent in MVPA (%MVPA), @entity1 , and IM were calculated. Generalized estimating equations were used to determine the relationship between daily %MVPA and @entity1 and between daily %MVPA and IM, accounting for age, sex, ethnicity, distance to school, day of the week, and numeric day of data collection. RESULTS: A significant positive relationship was observed between %MVPA and both @entity1 and IM. For every unit increase in the daily percentage of trips made that were @entity1 or IM, we found an average increase of 1.28% (95% CI 0.87%, 1.70%) and 1.15% (95% CI 0.71%, 1.59%) time in MVPA, respectively. CONCLUSION: @entity0 's @entity1 and IM are associated with increased MVPA during out-of-school hours.

title: XXXX 's Out-of-School Independently Mobile Trips, Active Travel, and Physical Activity: A Cross-Sectional Examination from the Kids in the City Study.

answer: @entity0


abstract: UNASSIGNED: Cytotoxic anticancer chemotherapy affects pituitary-testicular hormonal axis in @entity0 and in animals. This study investigated the effects on Leydig cells of three cycles of @entity6 , @entity7 and @entity4 (0.75, 7.5, and 1.5mg/kg, respectively; @entity9 ) chemotherapy in @entity1 testis. The chemotherapy has induced @entity5 of and degenerative changes in Leydig cells at the end of @entity9 exposure, which remained so even after a recovery time of 63 days. The increased testicular oxidative stress at the end of the chemotherapy returned to normal level after the recovery time. The chemotherapy has stimulated the transcription of @entity10 ( @entity10 ), @entity12 ( @entity12 ), cytochrome P450 @entity2 side-chain cleavage ( @entity8 ), @entity13 , and inhibited that of 17b-hydroxysteroid dehydrogenase ( @entity14 ) and @entity11 in association with increased @entity2 and decreased @entity3 levels. Even after the recovery time, the chemotherapy still had inhibitory effects on the transcription of all of the above genes in addition to luteinizing hormone receptor and @entity15 , but not on the @entity12 gene. The @entity2 and @entity3 levels also did not show any significant differences with the control group. The decreased @entity3 level at the end of chemotherapy was probably due to inhibition of @entity15 and @entity14 genes. In conclusion, clinically relevant dose-levels and treatment protocols of @entity9 chemotherapy adversely affect Leydig cell function. The @entity9 chemotherapy inhibits the transcription of steroidogenic enzymes and that these effects sustain over an extended period of time without returning to normal levels.

title: Effects of @entity6 , @entity7 and XXXX treatment on Leydig cell structure and transcription of steroidogenic enzymes in @entity1 testis.

answer: @entity4


abstract: UNASSIGNED: Cytotoxic anticancer chemotherapy affects pituitary-testicular hormonal axis in @entity0 and in animals. This study investigated the effects on Leydig cells of three cycles of @entity6 , @entity7 and @entity4 (0.75, 7.5, and 1.5mg/kg, respectively; @entity9 ) chemotherapy in @entity1 testis. The chemotherapy has induced @entity5 of and degenerative changes in Leydig cells at the end of @entity9 exposure, which remained so even after a recovery time of 63 days. The increased testicular oxidative stress at the end of the chemotherapy returned to normal level after the recovery time. The chemotherapy has stimulated the transcription of @entity10 ( @entity10 ), @entity12 ( @entity12 ), cytochrome P450 @entity2 side-chain cleavage ( @entity8 ), @entity13 , and inhibited that of 17b-hydroxysteroid dehydrogenase ( @entity14 ) and @entity11 in association with increased @entity2 and decreased @entity3 levels. Even after the recovery time, the chemotherapy still had inhibitory effects on the transcription of all of the above genes in addition to luteinizing hormone receptor and @entity15 , but not on the @entity12 gene. The @entity2 and @entity3 levels also did not show any significant differences with the control group. The decreased @entity3 level at the end of chemotherapy was probably due to inhibition of @entity15 and @entity14 genes. In conclusion, clinically relevant dose-levels and treatment protocols of @entity9 chemotherapy adversely affect Leydig cell function. The @entity9 chemotherapy inhibits the transcription of steroidogenic enzymes and that these effects sustain over an extended period of time without returning to normal levels.

title: Effects of @entity6 , XXXX and @entity4 treatment on Leydig cell structure and transcription of steroidogenic enzymes in @entity1 testis.

answer: @entity7


abstract: UNASSIGNED: Cytotoxic anticancer chemotherapy affects pituitary-testicular hormonal axis in @entity0 and in animals. This study investigated the effects on Leydig cells of three cycles of @entity6 , @entity7 and @entity4 (0.75, 7.5, and 1.5mg/kg, respectively; @entity9 ) chemotherapy in @entity1 testis. The chemotherapy has induced @entity5 of and degenerative changes in Leydig cells at the end of @entity9 exposure, which remained so even after a recovery time of 63 days. The increased testicular oxidative stress at the end of the chemotherapy returned to normal level after the recovery time. The chemotherapy has stimulated the transcription of @entity10 ( @entity10 ), @entity12 ( @entity12 ), cytochrome P450 @entity2 side-chain cleavage ( @entity8 ), @entity13 , and inhibited that of 17b-hydroxysteroid dehydrogenase ( @entity14 ) and @entity11 in association with increased @entity2 and decreased @entity3 levels. Even after the recovery time, the chemotherapy still had inhibitory effects on the transcription of all of the above genes in addition to luteinizing hormone receptor and @entity15 , but not on the @entity12 gene. The @entity2 and @entity3 levels also did not show any significant differences with the control group. The decreased @entity3 level at the end of chemotherapy was probably due to inhibition of @entity15 and @entity14 genes. In conclusion, clinically relevant dose-levels and treatment protocols of @entity9 chemotherapy adversely affect Leydig cell function. The @entity9 chemotherapy inhibits the transcription of steroidogenic enzymes and that these effects sustain over an extended period of time without returning to normal levels.

title: Effects of XXXX , @entity7 and @entity4 treatment on Leydig cell structure and transcription of steroidogenic enzymes in @entity1 testis.

answer: @entity6


abstract: UNASSIGNED: Cytotoxic anticancer chemotherapy affects pituitary-testicular hormonal axis in @entity0 and in animals. This study investigated the effects on Leydig cells of three cycles of @entity6 , @entity7 and @entity4 (0.75, 7.5, and 1.5mg/kg, respectively; @entity9 ) chemotherapy in @entity1 testis. The chemotherapy has induced @entity5 of and degenerative changes in Leydig cells at the end of @entity9 exposure, which remained so even after a recovery time of 63 days. The increased testicular oxidative stress at the end of the chemotherapy returned to normal level after the recovery time. The chemotherapy has stimulated the transcription of @entity10 ( @entity10 ), @entity12 ( @entity12 ), cytochrome P450 @entity2 side-chain cleavage ( @entity8 ), @entity13 , and inhibited that of 17b-hydroxysteroid dehydrogenase ( @entity14 ) and @entity11 in association with increased @entity2 and decreased @entity3 levels. Even after the recovery time, the chemotherapy still had inhibitory effects on the transcription of all of the above genes in addition to luteinizing hormone receptor and @entity15 , but not on the @entity12 gene. The @entity2 and @entity3 levels also did not show any significant differences with the control group. The decreased @entity3 level at the end of chemotherapy was probably due to inhibition of @entity15 and @entity14 genes. In conclusion, clinically relevant dose-levels and treatment protocols of @entity9 chemotherapy adversely affect Leydig cell function. The @entity9 chemotherapy inhibits the transcription of steroidogenic enzymes and that these effects sustain over an extended period of time without returning to normal levels.

title: Effects of @entity6 , @entity7 and @entity4 treatment on Leydig cell structure and transcription of steroidogenic enzymes in XXXX testis.

answer: @entity1


abstract: A 47-year-old female @entity0 with @entity3 underwent endoscopic injection sclerotherapy for esophageal varices 13  years ago. The @entity0 had no past history of hysterectomy or any other @entity5 . She was admitted to our hospital because of persistent @entity4 and exacerbation of @entity1 . A contrast-enhanced computed tomography scan revealed marked dilation of not only the inferior mesenteric vein, but also the left ovarian vein, the uterine vein and the internal iliac vein. A celiac arteriography showed that the blood in the splenic vein was flowing almost totally hepatofugally into the dilated inferior mesenteric vein. An ovarian venography demonstrated knob-shaped dilation of the left ovarian vein draining into the left internal iliac vein. A proximally wedged left ovarian venography visualized the right ovarian vein and the right internal iliac vein with contrast medium via a palisade venous plexus from the dilated uterine and ovarian veins. @entity2 ( @entity2 ) was performed to increase platelet count and to reduce splenic venous blood flow into the ovarian vein. Following the @entity2 , the platelet count increased, and the blood flow in the dilated ovarian vein and uterine vein diminished. In addition, the portal blood flow became hepatopetal, and remarkably increased. There has as yet been no case report in which @entity4 developed in @entity0 with @entity3 without any past history of hysterectomy or other @entity5 . The present case report may be warranted in view of the rarity of the condition.

title: XXXX in a @entity0 with @entity3 without a past history of laparotomy: successful treatment with partial splenic artery embolization.

answer: @entity4


abstract: A 47-year-old female @entity0 with @entity3 underwent endoscopic injection sclerotherapy for esophageal varices 13  years ago. The @entity0 had no past history of hysterectomy or any other @entity5 . She was admitted to our hospital because of persistent @entity4 and exacerbation of @entity1 . A contrast-enhanced computed tomography scan revealed marked dilation of not only the inferior mesenteric vein, but also the left ovarian vein, the uterine vein and the internal iliac vein. A celiac arteriography showed that the blood in the splenic vein was flowing almost totally hepatofugally into the dilated inferior mesenteric vein. An ovarian venography demonstrated knob-shaped dilation of the left ovarian vein draining into the left internal iliac vein. A proximally wedged left ovarian venography visualized the right ovarian vein and the right internal iliac vein with contrast medium via a palisade venous plexus from the dilated uterine and ovarian veins. @entity2 ( @entity2 ) was performed to increase platelet count and to reduce splenic venous blood flow into the ovarian vein. Following the @entity2 , the platelet count increased, and the blood flow in the dilated ovarian vein and uterine vein diminished. In addition, the portal blood flow became hepatopetal, and remarkably increased. There has as yet been no case report in which @entity4 developed in @entity0 with @entity3 without any past history of hysterectomy or other @entity5 . The present case report may be warranted in view of the rarity of the condition.

title: @entity4 in a @entity0 with XXXX without a past history of laparotomy: successful treatment with partial splenic artery embolization.

answer: @entity3


abstract: A 47-year-old female @entity0 with @entity3 underwent endoscopic injection sclerotherapy for esophageal varices 13  years ago. The @entity0 had no past history of hysterectomy or any other @entity5 . She was admitted to our hospital because of persistent @entity4 and exacerbation of @entity1 . A contrast-enhanced computed tomography scan revealed marked dilation of not only the inferior mesenteric vein, but also the left ovarian vein, the uterine vein and the internal iliac vein. A celiac arteriography showed that the blood in the splenic vein was flowing almost totally hepatofugally into the dilated inferior mesenteric vein. An ovarian venography demonstrated knob-shaped dilation of the left ovarian vein draining into the left internal iliac vein. A proximally wedged left ovarian venography visualized the right ovarian vein and the right internal iliac vein with contrast medium via a palisade venous plexus from the dilated uterine and ovarian veins. @entity2 ( @entity2 ) was performed to increase platelet count and to reduce splenic venous blood flow into the ovarian vein. Following the @entity2 , the platelet count increased, and the blood flow in the dilated ovarian vein and uterine vein diminished. In addition, the portal blood flow became hepatopetal, and remarkably increased. There has as yet been no case report in which @entity4 developed in @entity0 with @entity3 without any past history of hysterectomy or other @entity5 . The present case report may be warranted in view of the rarity of the condition.

title: @entity4 in a XXXX with @entity3 without a past history of laparotomy: successful treatment with partial splenic artery embolization.

answer: @entity0