abstract: AIM OF THE STUDY: To develop a clinically relevant and qualitative brain magnetic resonance imaging (MRI) scoring system for acute stage @entity1 @entity2 @entity0 . METHODS: Consecutive @entity1 post- @entity2 @entity0 were prospectively enrolled. Routine brain MRI sequences were scored by two independent and blinded experts. Predefined brain regions were qualitatively scored on diffusion-weighted imaging (DWI) sequences according to the severity of the abnormality on a scale from 0 to 4. The mean score provided by the raters determined poor outcome defined under the Cerebral Performance Categories 3, 4, or 5. DWI scans were repeated after @entity4 ( @entity4 ). The same qualitative scoring system was applied and results were compared to the initial scores. RESULTS: Out of 24 recruited @entity0 , 19 with brain MRI scans were included. Of the 19 included @entity0 , seven showed a good outcome at hospital discharge and 12 @entity0 showed poor neurologic outcome. Median time from the arrest to the initial DWI was 166min (IQR 114-240min). At 100% specificity, the overall, cortex, and cortex plus deep grey nuclei scores predicted poor @entity0 outcome with a sensitivity of 91.7-100% (95% CI). Follow-up DWI scans after @entity4 showed worse results than initial scans. CONCLUSION: A qualitative MRI scoring system effectively assessed the severity of @entity3 following @entity2 . The scoring system may provide useful prognostic information in @entity1 @entity2 @entity0 .

title: Efficacy of diffusion-weighted magnetic resonance imaging performed before @entity4 in predicting clinical outcome in @entity1 XXXX .

answer: @entity2


abstract: BACKGROUND: The significance of pre-arrest factors in out-of-hospital @entity7 (OHCA) witnessed by emergency medical services (EMS) is not well established. The purpose of this study was to assess the association between prodromal symptoms and pre-arrest clinical observations on the arresting rhythm and survival in EMS witnessed OHCA. METHODS: Between 1st January 2003 and 31st December 2011, 1056 adult EMS witnessed arrests of a presumed cardiac aetiology were identified from the Victorian Ambulance Cardiac Arrest Registry. Pre-arrest prodromal features and clinical characteristics were extracted from the @entity0 care record. Backward elimination logistic regression was used to identify pre-arrest factors associated with an initial shockable rhythm and survival to hospital discharge. RESULTS: The median age was 73.0 years, 690 (65.3%) were male, and the rhythm of arrest was shockable in 465 (44.0%) cases. The most commonly reported prodromal symptoms prior to arrest were @entity4 (48.8%), dyspnoea (41.8%) and altered consciousness (37.8%). An unrecordable systolic blood pressure was observed in 34.4%, a respiratory rate <13 or >24min(-1) was present in 43.1%, and 45.5% had a Glasgow @entity5 score <15. In the multivariable analysis, the following pre-arrest factors were significantly associated with survival: age, public location, aged care facility, @entity4 , arm or shoulder @entity2 , dyspnoea, @entity8 , @entity3 , @entity6 , pulse rate, systolic blood pressure, respiratory rate, Glasgow @entity5 score, @entity1 and inotrope administration. CONCLUSION: Pre-arrest factors are strongly associated with the arresting rhythm and survival following EMS witnessed OHCA. Potential opportunities to improve outcomes exist by way of early recognition and management of @entity0 at risk of OHCA.

title: The significance of pre-arrest factors in out-of-hospital XXXX witnessed by emergency medical services: A report from the Victorian Ambulance Cardiac Arrest Registry.

answer: @entity7


abstract: PURPOSE: The purpose of this study was to evaluate functional outcomes of reverse shoulder arthroplasty (RSA) in @entity0 with acute @entity1 and sequelae of the @entity2 . METHODS: Thirty-seven @entity0 were treated with RSA for acute @entity1 and sequelae of a @entity2 . The average age was 73  years (range 50-87 years). Twenty-one @entity0 had had no previous surgery, seven @entity0 had acute @entity1 and 14 @entity0 had chronic @entity1 . Sixteen @entity0 had had previous surgery. Active range of motion and Constant score were evaluated at a minimum follow-up of two  years. RESULTS: Active elevation was 102  , external rotation 24  , and internal rotation was up to L4 in all @entity0 . In the group of @entity0 without previous surgery treated with RSA, elevation was 116  , external rotation 24  , and internal rotation up to L3. In the group of @entity0 with previous surgery treated with RSA, elevation was 84  , external rotation 19  , and internal rotation up to L4. In the group of @entity0 with acute @entity1 treated with RSA, elevation was 124  , external rotation 28  , and internal rotation up to L4. In the group of @entity0 with chronic or sequel of the @entity1 treated with RSA elevation was 114   , external rotation 28  , and internal rotation up to L3. Constant score in all @entity0 was 54. Constant score in @entity0 without previous surgery treated with RSA was 68 and with previous surgery it was 42. CONCLUSION: @entity0 without previous surgery treated with RSA for @entity1 had better functional results than @entity0 who had undergone previous surgery.

title: Reverse shoulder arthroplasty in acute XXXX provides better results than in revision procedures for @entity1 sequelae.

answer: @entity1


abstract: PURPOSE: The purpose of this study was to evaluate functional outcomes of reverse shoulder arthroplasty (RSA) in @entity0 with acute @entity1 and sequelae of the @entity2 . METHODS: Thirty-seven @entity0 were treated with RSA for acute @entity1 and sequelae of a @entity2 . The average age was 73  years (range 50-87 years). Twenty-one @entity0 had had no previous surgery, seven @entity0 had acute @entity1 and 14 @entity0 had chronic @entity1 . Sixteen @entity0 had had previous surgery. Active range of motion and Constant score were evaluated at a minimum follow-up of two  years. RESULTS: Active elevation was 102  , external rotation 24  , and internal rotation was up to L4 in all @entity0 . In the group of @entity0 without previous surgery treated with RSA, elevation was 116  , external rotation 24  , and internal rotation up to L3. In the group of @entity0 with previous surgery treated with RSA, elevation was 84  , external rotation 19  , and internal rotation up to L4. In the group of @entity0 with acute @entity1 treated with RSA, elevation was 124  , external rotation 28  , and internal rotation up to L4. In the group of @entity0 with chronic or sequel of the @entity1 treated with RSA elevation was 114   , external rotation 28  , and internal rotation up to L3. Constant score in all @entity0 was 54. Constant score in @entity0 without previous surgery treated with RSA was 68 and with previous surgery it was 42. CONCLUSION: @entity0 without previous surgery treated with RSA for @entity1 had better functional results than @entity0 who had undergone previous surgery.

title: Reverse shoulder arthroplasty in acute @entity1 provides better results than in revision procedures for XXXX sequelae.

answer: @entity1


abstract: To investigate the seasonal variations in ambulatory blood pressure patterns, 24-h blood pressure was measured every 15 minutes noninvasively in ten young normotensive @entity0 . Urine was collected every 4 hours. The examinations were repeated in spring, summer, autumn, and winter in a standardized living environment. The 24-h average @entity1 did not differ significantly among the seasons. Similarly, there were no significant differences in the average values of either daytime or nighttime blood pressure. In contrast, the average pulse rate during nighttime was significantly higher in winter than in summer (64 +/- 2 beats/min vs. 59 +/- 2 beats/min, p < 0.05). The variabilities of either blood pressure or pulse rate did not change significantly among the seasons. The mesors and acrophases of both @entity1 , determined by a single cosinor method, were not significantly different among the seasons. On the other hand, the acrophase of pulse rate appeared significantly later in winter (16:19) compared with those in spring (14:54), summer (14:42), and autumn (14:21). Urine volume and urinary excretion of @entity2 were significantly greater in winter than in summer. These results indicate that the 24-h pattern of blood pressure is reproducible and shows no seasonal difference in young normotensive @entity0 .

title: Seasonal variation in 24-h blood pressure pattern of young normotensive XXXX .

answer: @entity0


abstract: STUDY DESIGN: Case report. BACKGROUND: A case of an athlete with @entity2 has not been previously reported although there have been a number of case reports and case series of non-athletes with @entity2 . This case study reports motor control intervention for an amateur baseball pitcher with @entity1 of the right trapezius who lost pitching control after changing his pitching technique. The subject was able to restore ball control during overhead throwing after physiotherapy. CASE DESCRIPTION: The subject of this case report was a 20-year-old amateur male baseball pitcher, who presented with long-standing @entity1 of the right trapezius and a six month history of loss of ball control with shoulder @entity0 during pitching. He was seen for a second opinion following unsuccessful conservative management and underwent physiotherapy to restore his ball control during pitching. Restriction of cervical rotation range of motion and decreased position sense during shoulder abduction and external rotation were revealed in the physical examination. Proprioceptive exercise was commenced with and without visual feedback to acquire a reproducible abduction angle in the cocking phase of a baseball pitch. His pitching form was modified to ensure his arm was being raised effectively in the cocking phase. Pitching drills that were utilized were targeted motor control of the upper quarter, and were progressed in steps. Cervical joint mobilization was undertaken to allow adequate range of motion for visualization of the target while pitching. OUTCOMES: His position sense and cervical range of motion were restored. His pitching control was restored with conservative therapy on by the eighth week of intervention. DISCUSSION: The subject was able to return to competitive level of amateur baseball with accurate ball control. This case report demonstrates that achievement of control of a skilled upper quarter activity, such as baseball pitching, is possible with conservative management even in the presence of paralysis of trapezius, a major contributor to the movement. LEVEL OF EVIDENCE: 4 (single case report).

title: Motor control training for an amateur baseball pitcher with XXXX of trapezius: a case report.

answer: @entity1


abstract: PURPOSE: To describe the initial and follow-up CT features of @entity3 associated with anti-synthetase syndrome ( @entity7 ). MATERIALS AND METHODS: Two independent thoracic radiologists retrospectively analysed thin-section CT images obtained at diagnosis of @entity7 in 33 @entity0 (17 positive for anti-Jo1, 13 for anti-PL12, and three for anti-PL7 antibodies). They evaluated the pattern, distribution and extent of the @entity4 . They also evaluated the change in findings during follow-up (median 27 months; range 13-167 months) in 26 @entity0 . RESULTS: At diagnosis, ground-glass opacities (100%), reticulations (87%) and traction @entity6 (76%) were the most common CT findings. Consolidations were present in 45% of @entity0 . A @entity3 ( @entity3 ), @entity5 ( @entity5 ) or mixed @entity1 pattern were observed in 15 out of 33 (45%), seven out of 33 (21%) and eight out of 33 (24%) @entity0 , respectively, whereas the CT pattern was indeterminate in three @entity0 . During follow-up, consolidations decreased or disappeared in 11 out of 12 @entity0 (92%), among which seven within the first 6 months, but honeycombing progressed or appeared in ten out of 26 @entity0 (38%) and overall disease extent increased in nine out of 26 @entity0 (35%). CONCLUSION: CT features at diagnosis of @entity7 mainly suggest @entity3 and @entity5 , isolated or in combination. Consolidations decrease or disappear in most cases but the disease may progress to @entity2 in more than one third of @entity0 .

title: XXXX in anti-synthetase syndrome: Initial and follow-up CT findings.

answer: @entity3


abstract: UNASSIGNED: In this paper, based on the Flemish biomonitoring programs, we describe the associations between internal exposure to organochlorine pollutants and to @entity5 (measured in 2004-2005 for adults aged 50-65 years) and self-reported health status obtained through a questionnaire in November 2011. Dioxin-like activity in serum showed a significant positive association with risk of @entity1 for @entity0 . After adjustment for confounders and covariates, the odds ratio for an exposure equal to the 90th percentile was 2.4 times higher than for an exposure equal to the 10th percentile. For both @entity0 and @entity0 @entity8 -like activity and serum @entity9 (HCB) showed a significant positive association with risk of @entity2 and of @entity3 . Detailed analysis suggested that an increase in BMI might be part of the mechanism through which @entity9 contributes to @entity2 and @entity3 . Serum @entity7 ( @entity7 ) concentration showed a significant positive association with @entity2 and @entity3 in @entity0 , but not in women. Serum polychlorinated biphenyl ( @entity6 ) 118 showed a significant positive association with @entity2 in both @entity0 and @entity0 , and after adjustment for correlated exposures, also with @entity3 in @entity0 . Urinary @entity5 concentrations showed a significant positive association with @entity3 . Urinary @entity5 concentrations were (in 2004-2005) significantly higher in @entity0 who felt in less than good health (in 2011) than in @entity0 who felt in very good health. After adjustment for correlated exposures (to HCB, @entity7 and @entity10 ) marker @entity4 showed a significant negative association with @entity2 and @entity3 . Serum @entity7 showed in @entity0 a significant negative association with risk of diseases based on atheromata. Our findings suggest that exposure to pollutants can lead to an important increase in the risk of diseases such as @entity1 , @entity2 and @entity3 . Some pollutants may possibly also decrease the risk of some health problems, although this requires confirmation by other approaches.

title: Internal exposure to organochlorine pollutants and XXXX and self-reported health status: A prospective study.

answer: @entity5


abstract: @entity0 @entity3 is thought to develop through progressive stages from @entity8 to @entity9 , @entity5 , @entity11 , and finally invasive @entity1 . In this study, we used tissue microdissection to examine loss of heterozygosity of chromosomes 3p21, 5q21, and 9p21 at each stage of the epithelial progression to invasive @entity1 . Forty-eight premalignant/malignant bronchial sites were biopsied from 13 @entity0 (including 9 subjects without @entity1 ) using fluorescence bronchoscopy. Eighteen sites with moderate/severe @entity5 in 6 @entity0 were subjected to bronchoscopic and molecular follow-up during a 3-month to 2-year period. Seven separate cases of advanced @entity6 were also analyzed. From the baseline biopsies, the prevalence of 3p and 9p deletions increased significantly from no deletion in the @entity7 /metaplasia samples (n = 9) to 37 and 31% of the informative cases, respectively, in the @entity5 samples (n = 29), to 100 and 83%, respectively, for the @entity4 in situ (n = 6), and 100% in the invasive @entity1 (n = 11). Chromosome 5q deletion was significantly more frequent in invasive @entity1 (70% of the informative cases) as compared to @entity11 (40%), @entity5 (33%), and @entity7 /metaplasia samples (11%). The number of chromosome alterations also increased significantly from the lowest to the highest grade lesions, showing evidence of accumulation of @entity2 from one group to another. The molecular follow-up analysis showed that the same genomic alteration can persist in a given @entity12 bronchial area for several months or years, and that the persistence or the regression of the @entity2 is well correlated with the evolution of the disease on follow-up. Our results suggest that molecular analysis of bronchial biopsies obtained by fluorescence bronchoscopy may be a very useful means to study the natural history of preinvasive @entity10 and the outcome of interventions, such as with chemopreventive treatment.

title: Evidence of cumulative gene losses with progression of XXXX of the bronchus.

answer: @entity4


abstract: BACKGROUND: Affective disturbances involving alterations of mood, @entity1 and @entity0 may be early symptoms of medical illnesses. The aim of this paper was to provide a systematic review of the literature with qualitative data synthesis. METHODS: MEDLINE, PsycINFO, EMBASE, Cochrane, and ISI Web of Science were systematically searched from inception to February 2014. Search terms were 'prodrome/early symptom', combined using the Boolean 'AND' operator with ' @entity1 / @entity3 / @entity2 /hypomania/ @entity0 /irritable mood/hostility', combined with the Boolean 'AND' operator with 'medical illness/medical disorder'. PRISMA guidelines were followed. RESULTS: A total of 21 studies met the inclusion criteria and were analyzed. @entity3 was found to be the most common affective prodrome of medical disorders and was consistently reported in @entity5 , @entity8 , @entity10 , @entity6 , @entity4 , @entity9 , and @entity7 . @entity2 , @entity1 and @entity0 were less frequent. CONCLUSIONS: Physicians may not pursue medical workup of cases that appear to be @entity0 in nature. They should be alerted that disturbances in mood, @entity1 and @entity0 may antedate the appearance of a medical disorder.

title: Mood and XXXX as early manifestations of medical illness: a systematic review.

answer: @entity1


abstract: Forty male and 40 female @entity0 were randomly assigned to 1 of 4 experimental groups. Half of the animals of each gender were exercised by jumping (weighted by a vest with up to 70% body weight) to a height of 16 cm 20 times X d-1 (30 s between jumps) 5 d X wk-1 for 8 wk. Half of the exercised animals and half of the sedentary animals were injected with the anabolic @entity1 durabolin (0.2 mg in 0.1 ml @entity3 seed oil) 6 d X wk-1 for the last 3 wk of the 8-wk exercise program. The other animals were injected with 0.1 ml of @entity3 seed oil (as a placebo) on the same schedule. At the end of the 8-wk program, blood was drawn from the right atria of the anesthetized animals. Plasmas were analyzed for total @entity2 (TC) and high density lipoprotein @entity2 (HDL-C) concentrations. Low density lipoprotein @entity2 (LDL-C) concentration was estimated as the difference between these two parameters (TC - HDL-C). A three-factor analysis of variance (2 X 2 X 2) demonstrated that there was a significant (P less than 0.05) gender effect (males greater than females), but no @entity1 or exercise main effects for TC. There were significant (P less than 0.05) @entity1 and exercise main effects for both HDL-C and estimated LDL-C, as well as a significant gender main effect for estimated LDL-C (but not HDL-C).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effects of exercise and anabolic steroids on total and lipoprotein XXXX concentrations in male and female @entity0 .

answer: @entity2


abstract: Forty male and 40 female @entity0 were randomly assigned to 1 of 4 experimental groups. Half of the animals of each gender were exercised by jumping (weighted by a vest with up to 70% body weight) to a height of 16 cm 20 times X d-1 (30 s between jumps) 5 d X wk-1 for 8 wk. Half of the exercised animals and half of the sedentary animals were injected with the anabolic @entity1 durabolin (0.2 mg in 0.1 ml @entity3 seed oil) 6 d X wk-1 for the last 3 wk of the 8-wk exercise program. The other animals were injected with 0.1 ml of @entity3 seed oil (as a placebo) on the same schedule. At the end of the 8-wk program, blood was drawn from the right atria of the anesthetized animals. Plasmas were analyzed for total @entity2 (TC) and high density lipoprotein @entity2 (HDL-C) concentrations. Low density lipoprotein @entity2 (LDL-C) concentration was estimated as the difference between these two parameters (TC - HDL-C). A three-factor analysis of variance (2 X 2 X 2) demonstrated that there was a significant (P less than 0.05) gender effect (males greater than females), but no @entity1 or exercise main effects for TC. There were significant (P less than 0.05) @entity1 and exercise main effects for both HDL-C and estimated LDL-C, as well as a significant gender main effect for estimated LDL-C (but not HDL-C).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effects of exercise and anabolic steroids on total and lipoprotein @entity2 concentrations in male and female XXXX .

answer: @entity0


abstract: The incidence of @entity3 is increasing. Approximately 20% of @entity0 present with untreatable, disseminated disease. The remaining 80% are generally treated by intended curative resection. Unfortunately, about 40% of the Dukes B2 and C @entity0 will develop recurrent disease. Of these @entity0 , about one third will develop hepatic @entity1 , one fifth @entity4 , one fifth @entity5 , one tenth retroperitoneal @entity1 , and one twentieth anastomotic recurrences. @entity2 @entity0 may have pelvic recurrence rates as high as one third. Unfortunately, only about one fifth of the Dukes B2 and C @entity0 will initially develop recurrences at only one site and are, thus, potentially curable. Indeed, when considering all @entity3 @entity0 , resectable recurrences will be detected in the liver in only 2%, regional recurrences in about 10%, in the lungs in 2%, anastomotic recurrences in less than 1%, and in the ovaries in 1%. In general, long-term survival can be achieved in about 30% of these @entity0 with salvage surgery. The goal of intensive follow-up programs has been to identify these sole site recurrences at an earlier, asymptomatic stage and thereby improve survival. Unfortunately this laudable goal has not been achieved. Intensive (and expensive) follow-up programs consistently achieve long-term survival in 0% to 4% of @entity0 . Reliance on symptoms, however, achieves remarkably similar end results.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Sensitivity versus cost effectiveness in postoperative follow-up for XXXX .

answer: @entity3


abstract: UNASSIGNED: The objective of the present study was to evaluate whether integrated @entity3 -PET/MRI can improve the diagnostic workup in @entity0 with cardiac masses. METHODS: Twenty @entity0 were prospectively assessed using integrated cardiac @entity3 -PET/MRI: 16 @entity0 with cardiac masses of unknown identity and four @entity0 with @entity2 after surgical therapy. All scans were performed on an integrated 3-T PET/MR device (mMR Biograph, Siemens Healthcare, Erlangen, Germany). The MR protocol consisted of HASTE, cine and T2-weighted images as well as T1-weighted images before and after injection of @entity7 . PET data acquisition was performed simultaneously to the MR scan after injection of 199  58 MBq @entity3 . @entity0 were prepared with a high-fat, low- @entity5 diet in a period of 24 hours before the examination and 50 IU/kg of unfractionated heparin were administered intravenously 15 minutes prior the @entity3 injection. RESULTS: Cardiac masses were diagnosed as follows: 3 x metastases, 1 x direct tumor infiltration via pulmonary vein, 2 x local relapse of @entity1 after surgery, 1 @entity6 , 2 x scar/patch tissue after surgery of @entity1 , 4 x @entity8 , 1 x fibroelastoma, 3 x caseous calcification of mitral annulus (CCMA), 3 x @entity4 . SUVmax in malignant lesions was significantly higher than in non-malignant cases (13.2  6.2 vs. 2.3  1.2, P = 0.0004). Using a threshold of >=  5.2, SUVmax was found to yield 100% sensitivity and 92% specificity for the differentiation between malignant and non-malignant cases. T2-weighted hyperintensity and contrast-enhancement both yielded 100% sensitivity, but a weak specificity of 54% and 46%, respectively. Morphologic tumor features as assessed by cine MRI yielded 86% sensitivity and 92% specificity. Consent reading using all available MR features yielded 100% sensitivity and 92% specificity. A Boolean 'AND' combination of SUVmax >=  5.2 with consent MRI reading improved sensitivity and specificity to 100%. CONCLUSION: In selected @entity0 , @entity3 -PET/MRI can improve the noninvasive diagnosis and follow-up of cardiac masses.

title: Integrated XXXX -PET/MRI in the assessment of cardiac masses: A pilot study.

answer: @entity3


abstract: The @entity0 metallothionein ( @entity6 ) IB gene ( @entity5 ) is located in a region of @entity0 DNA containing at least four tandemly arranged @entity6 genes. As deduced from its sequence, @entity5 is likely to encode a functional protein. However, the predicted @entity3 sequence differed from the @entity6 -I @entity3 sequence in four positions. Most remarkable was the presence of an additional @entity2 . Like other @entity6 genes, @entity5 has at least two copies of the metal-responsive element upstream from the transcription initiation site. These elements probably are responsible for the metal responsiveness of the @entity5 promoter, leading to inducible expression of fused heterologous genes. Unlike the @entity6 -IIA and @entity6 -IA genes described previously, which are expressed in many different cell types, a high level of expression of the endogenous @entity5 gene could be detected only in @entity0 @entity1 and @entity4 cell lines. Therefore, this is the first @entity6 gene described which exhibits tissue specificity of expression. This specificity is controlled by a cis-acting mechanism involving methylation, since incubation of nonexpressing cells with an inhibitor of DNA methylation led to activation of the @entity5 gene. In support of this notion, we found that the 5' flanking region of the @entity5 gene was highly methylated in HeLa cells, a nonexpressing cell type, but it was not methylated in a @entity1 (expressing) cell line.

title: Structure and tissue-specific expression of the @entity0 XXXX gene.

answer: @entity5


abstract: The @entity0 metallothionein ( @entity6 ) IB gene ( @entity5 ) is located in a region of @entity0 DNA containing at least four tandemly arranged @entity6 genes. As deduced from its sequence, @entity5 is likely to encode a functional protein. However, the predicted @entity3 sequence differed from the @entity6 -I @entity3 sequence in four positions. Most remarkable was the presence of an additional @entity2 . Like other @entity6 genes, @entity5 has at least two copies of the metal-responsive element upstream from the transcription initiation site. These elements probably are responsible for the metal responsiveness of the @entity5 promoter, leading to inducible expression of fused heterologous genes. Unlike the @entity6 -IIA and @entity6 -IA genes described previously, which are expressed in many different cell types, a high level of expression of the endogenous @entity5 gene could be detected only in @entity0 @entity1 and @entity4 cell lines. Therefore, this is the first @entity6 gene described which exhibits tissue specificity of expression. This specificity is controlled by a cis-acting mechanism involving methylation, since incubation of nonexpressing cells with an inhibitor of DNA methylation led to activation of the @entity5 gene. In support of this notion, we found that the 5' flanking region of the @entity5 gene was highly methylated in HeLa cells, a nonexpressing cell type, but it was not methylated in a @entity1 (expressing) cell line.

title: Structure and tissue-specific expression of the XXXX @entity5 gene.

answer: @entity0


abstract: BACKGROUND AND AIM: Disturbances in intestinal motility have been described since XIX century, with a not very well understood pathogenesis and few therapeutic approaches. Considering chewing as an important stimulus to promote intestinal motility we designed this study to assess the efficacy of chewing gum to improve the @entity1 , and the clinical relevance of this intervention. METHODS: Were included @entity0 who underwent for elective left hemicolectomy during January 2007 to December 2008. The @entity0 were randomly assigned to receive chewing gum or nothing during the post-surgery period. The main outcomes assessed were duration of @entity1 , and reduction in hospitalization days. RESULTS: During the period of the study were included 32 @entity0 , were included mainly @entity0 (11 and 9 in treated and control @entity0 , respectively). The first defecation after surgery procedure occurs at (44.2    17.6 h) in the treated group and (55.5    14.8 h) in the control group (p = 0.05). In the same way oral tolerance was achieved faster in the treated group (p= 0.05). The hospital stay duration was not different among treated and not treated @entity0 . CONCLUSIONS: The use of chewing gum in @entity0 after elective left hemicolectomy, reduce the duration of the @entity1 . However, this does not reduce the hospital stay duration.

title: [Usefulness of chewing gum for the resolution of XXXX in left colon resections].

answer: @entity1


abstract: Molecular signatures in @entity3 ( @entity3 ) have been described that correlate with clinical outcome and response to therapy. The Proneural (PN) and @entity2 ( @entity2 ) signatures have been identified most consistently, but others including Classical (CLAS) have also been reported. The molecular signatures have been detected by array techniques at RNA and DNA level, but these methods are costly and cannot take into account individual contributions of different cells within a @entity1 . Therefore, the aim of this study was to investigate whether subclasses of newly diagnosed GBMs could be assessed and assigned by application of standard pathology laboratory procedures. 123 newly diagnosed GBMs were analyzed for the @entity1 cell expression of 23 pre-identified proteins and @entity4 amplification, together allowing for the subclassification of 65% of the @entity1 . Immunohistochemistry (IHC)-based profiling was found to be analogous to transcription-based profiling using a 9-gene transcriptional signature for PN and @entity2 subclasses. Based on these data a novel, minimal IHC-based scheme for subclass assignment for GBMs is proposed. Positive staining for IDH1R132H can be used for PN subclass assignment, high @entity4 expression for the CLAS subtype and a combined high expression of @entity5 , @entity6 and/or @entity7 for the @entity2 subclass. The application of the proposed scheme was evaluated in an independent @entity1 set, which resulted in similar subclass assignment rates as those observed in the training set. The IHC-based subclassification scheme proposed in this study therefore could provide very useful in future studies for stratification of individual @entity0 samples.

title: Subclassification of Newly Diagnosed XXXX through an Immunohistochemical Approach.

answer: @entity3


abstract: @entity1 sensor prolyl hydroxylases (PHDs) play important roles in the regulation of HIF-a and cell metabolisms. This study was designed to investigate the direct role of @entity8 in high fat-diet (HFD)-induced @entity3 . In HFD fed @entity0 , @entity8 expression was increased without significant changes in @entity10 and @entity9 levels in the heart. This was accompanied by a significant upregulation of @entity6 ( @entity6 ) and NF-kB. To explore the role of @entity8 in HFD-induced @entity3 , @entity8 conditional knockout @entity0 were fed a HFD for 16 weeks. Intriguingly, knockout of @entity8 significantly reduced @entity6 and NF-kb expression in HFD @entity0 hearts. Moreover, knockout of @entity8 inhibited @entity5 and @entity7 expression, and reduced cell apoptosis and macrophage infiltration in HFD @entity0 . This was accompanied by a significant improvement of cardiac function. Most importantly, conditional knockout of @entity8 at late stage in HFD @entity0 significantly improved @entity4 tolerance and reversed @entity3 . Our studies demonstrate that @entity8 activity is a critical contributor to the HFD-induced @entity3 . Inhibition of @entity8 attenuates HFD-induced @entity3 by a mechanism involving suppression of @entity6 /NF-kb pathway and @entity2 .

title: Conditional knockout of prolyl hydroxylase domain protein 2 attenuates high fat-diet-induced XXXX in @entity0 .

answer: @entity3


abstract: @entity1 sensor prolyl hydroxylases (PHDs) play important roles in the regulation of HIF-a and cell metabolisms. This study was designed to investigate the direct role of @entity8 in high fat-diet (HFD)-induced @entity3 . In HFD fed @entity0 , @entity8 expression was increased without significant changes in @entity10 and @entity9 levels in the heart. This was accompanied by a significant upregulation of @entity6 ( @entity6 ) and NF-kB. To explore the role of @entity8 in HFD-induced @entity3 , @entity8 conditional knockout @entity0 were fed a HFD for 16 weeks. Intriguingly, knockout of @entity8 significantly reduced @entity6 and NF-kb expression in HFD @entity0 hearts. Moreover, knockout of @entity8 inhibited @entity5 and @entity7 expression, and reduced cell apoptosis and macrophage infiltration in HFD @entity0 . This was accompanied by a significant improvement of cardiac function. Most importantly, conditional knockout of @entity8 at late stage in HFD @entity0 significantly improved @entity4 tolerance and reversed @entity3 . Our studies demonstrate that @entity8 activity is a critical contributor to the HFD-induced @entity3 . Inhibition of @entity8 attenuates HFD-induced @entity3 by a mechanism involving suppression of @entity6 /NF-kb pathway and @entity2 .

title: Conditional knockout of prolyl hydroxylase domain protein 2 attenuates high fat-diet-induced @entity3 in XXXX .

answer: @entity0


abstract: BACKGROUND: To investigate lifetime history of interpersonal abuse and risk of @entity1 in socio-economically distinct populations in the same city. METHODS: We examined associations of physical and @entity2 with the risk of @entity1 in two cohorts in the Boston area, including 2128 @entity0 recruited from a large urban- and suburban-managed care organization (Project Viva) and 1509 @entity0 recruited primarily from urban community health centres (Project ACCESS). Protocols for the studies were designed in parallel to allow us to merge data to enhance ethnic and socio-economic diversity in the combined sample. In mid-pregnancy, the Personal Safety Questionnaire and Edinburgh Postnatal Depression Scale (EPDS) were administered in both cohorts. An EPDS score >=  13 indicated probable @entity1 . Logistic regression was used to estimate the odds ratio (OR) of @entity1 associated with lifetime abuse history. RESULTS: Project ACCESS @entity0 were twice as likely as Project Viva @entity0 to report symptoms consistent with @entity1 : 22% of Project ACCESS @entity0 had EPDS scores >=  13, compared with 11% of Project Viva @entity0 . Fifty-seven percent of @entity0 in ACCESS and 46% in Viva reported lifetime physical and/or @entity2 . In merged analysis, @entity0 reporting lifetime physical or @entity2 had an OR for mid-pregnancy @entity1 of 1.63 [95% confidence interval (95% CI): 1.29-2.07], adjusted for age and race/ethnicity. Lifetime histories of physical abuse [OR 1.48 (95% CI 1.15-1.90)] and @entity2 [OR 1.68 (95% CI 1.24-2.28)] were independently associated with @entity1 . When @entity0 /teen, pre-pregnancy adult and pregnancy life periods were considered simultaneously, abuse in childhood was independently associated with an OR of 1.23 (95% CI 1.00-1.59), pre-pregnancy adult abuse with an OR of 1.70 (95% CI 1.31-2.21) and abuse during pregnancy with an OR of 1.77 (95% CI 1.14-2.74). Further adjustment for childhood socio-economic position made no material difference, and there were no clear interactions between abuse and adult socio-economic position. CONCLUSIONS: Physical and @entity2 histories were positively associated with @entity1 in two economically and ethnically distinct populations. Stronger associations with recent abuse may indicate that the association of abuse with @entity1 wanes with time or may result from less accurate recall of remote events.

title: Lifetime maternal experiences of abuse and risk of XXXX in two demographically distinct populations in Boston.

answer: @entity1


abstract: Chemical investigation of Guarea kunthiana fruits, guided by their effect on the reproductive cycle of engorged females of the @entity0 tick Rhipicephalus (Boophilus) microplus-a major economic problem to the livestock industry worldwide-led to isolation of 3b-O-tigloylmelianol, a new protolimonoid, from the bioactive @entity3 phase obtained by partitioning the crude @entity2 extract. An adult immersion test was performed. The compound strongly inhibited egg-laying and hatchability (99.2% effectiveness at a 0.01% concentration). @entity4 , isolated from the same phase, yielded unremarkable results in the adult immersion test. From the @entity1 phase, melianol, @entity5 , meliantriol, and a new protolimonoid, 3b-O-tigloylmeliantriol, were isolated, all of which, in the same manner as @entity4 , exhibited unremarkable results in the test. The structures of new and known compounds were mostly established by 1D- and 2D-NMR analyses and mass spectrometry data. This is the first report on the bioactivity of protolimonoids on the reproductive cycle of engorged females of R. (B.) microplus. 3b-O-Tigloylmelianol proved a promising candidate for the development of a biocontrol agent against the @entity0 tick investigated, as an alternative to environmentally hazardous synthetic acaricides.

title: 3b-O-Tigloylmelianol from Guarea kunthiana: A New Potential Agent to Control Rhipicephalus (Boophilus) microplus, a XXXX Tick of Veterinary Significance.

answer: @entity0


abstract: Diverse microarray and sequencing technologies have been widely used to characterize molecular changes in malignant epithelial cells in salivary neoplasms. Such gene expression studies to identify markers and targets in @entity1 cells are, however, compromised by the cellular heterogeneity of these @entity1 and by the difficulties to accrue matching controls representing normal salivary glands. Seventeen samples of primary @entity2 along with tissue from six normal major salivary glands were microdissected from @entity4 -embedded tissue. Pools of RNA from highly enriched preparations of these cell types were subjected to expression profiling using a whole-transcriptome shotgun sequencing experiment. In parallel, extracted genomic DNA was used for the 50 gene hotspot panel sequenome. @entity5 mutations in three @entity0 (18%), @entity7 mutations in one @entity0 (6%), but no @entity8 , MET, @entity9 , or @entity3 mutations. Using strict and conservative criteria, 220 differentially expressed transcripts were found, with 36% up- and 64% downregulated. The transcripts were annotated using NCBI Entrez Gene, and computationally analyzed with the Ingenuity Pathway Analysis program. From these significantly changed expressions, the analysis identified 26 @entity1 -related transcripts and 16 transcripts related to @entity6 overlapping with three @entity1 -related genes. These 220 differentially expressed genes including microRNAs provide here a sufficiently large set to specifically @entity2 and to identify novel and potentially important targets for diagnosis, prognosis, and therapy of this @entity1 .

title: Global transcriptome and sequenome analysis of formalin-fixed XXXX specimens.

answer: @entity2


abstract: The present paper describes a case of shoe @entity3 from DMF identified by the Poison Control Centre of Milan (PCCM), Italy, in 2009. A 35 year old @entity0 was affected by irritant reactions while wearing shoes contaminated with @entity4 . Exposure to these shoes was limited to a 8 hour period and was not repeated. In the following days the @entity0 suffered feet blistering and swelling limited to the area in contact with shoe vamp. Topical application of @entity2 did not prevent development of @entity1 . After 20 days from exposure, the lesions were healed but the skin remained red, dry and very sensitive. Chemical analyses of shoes quantified an average concentration of DMF of 383 mg/kg. The @entity0 refused to be patch tested. The observation here reported confirm that DMF should be considered a possible causal agent in shoe @entity3 . Documentation of cases exposed to this chemical provide a relevant support to characterize clinical manifestations and to identifying contaminated articles.

title: A case of XXXX to dimethylfumarate in shoes identified in Italy.

answer: @entity3


abstract: The relationship within @entity1 ( @entity1 ) pairs is based on pair-bond formation. This pair-bond is important for the successful rearing of the young and for the enhancement of reproductive success. Female marmosets bear twins which are carried mainly by males starting on the first day after the birth of the @entity0 . Little is known, however, about the patterns of sociosexual interaction between callitrichid pairs and how these interactions change after the arrival of offspring. To evaluate the effect of parturition on these interactions, three @entity2 of @entity1 were observed for four weeks before and four weeks after the birth of @entity0 . The animals were kept in individual outdoor cages of the Nucleo de Primatologia, under environmental conditions. The time spent in proximity was mainly attributable to the initiative of females before parturition and the initiative of males after the offspring arrived. Males were groomed more before than after the birth of @entity0 . In contrast, the amount of grooming received by females was the same in the two situations. These observations suggest that the relationship within pairs of @entity1 is slightly modified by the birth of @entity0 and indicates that males and females could be using different strategies to enhance their reproductive success.

title: The effect of parturition on the interactions within pairs of XXXX ( @entity1 ).

answer: @entity1


abstract: The relationship within @entity1 ( @entity1 ) pairs is based on pair-bond formation. This pair-bond is important for the successful rearing of the young and for the enhancement of reproductive success. Female marmosets bear twins which are carried mainly by males starting on the first day after the birth of the @entity0 . Little is known, however, about the patterns of sociosexual interaction between callitrichid pairs and how these interactions change after the arrival of offspring. To evaluate the effect of parturition on these interactions, three @entity2 of @entity1 were observed for four weeks before and four weeks after the birth of @entity0 . The animals were kept in individual outdoor cages of the Nucleo de Primatologia, under environmental conditions. The time spent in proximity was mainly attributable to the initiative of females before parturition and the initiative of males after the offspring arrived. Males were groomed more before than after the birth of @entity0 . In contrast, the amount of grooming received by females was the same in the two situations. These observations suggest that the relationship within pairs of @entity1 is slightly modified by the birth of @entity0 and indicates that males and females could be using different strategies to enhance their reproductive success.

title: The effect of parturition on the interactions within pairs of @entity1 ( XXXX ).

answer: @entity1


abstract: Adequate @entity0 ( @entity1 ) levels play a vital role in membrane excitability, cell contractility and metabolism, being a key nutrient for sustaining appropriate muscular contraction and performance levels in athletes. Phase angle (PhA), assessed by bioimpedance analysis (BIA), has been reported to be positively associated with most nutritional markers and is an indicator of membrane integrity and water distribution between intra- and extracellular spaces. The aim of the present study was to verify the association between @entity1 status and PhA as a predictor of cellular health, in a sample of judo athletes from a period of weight stability to prior to competition. Judo athletes (n  =  20) from the national team were evaluated on two occasions: during a period when body weight was stable (M1), and prior to competition (M2). Changes between these occasions were calculated as M2-M1. PhA was obtained by bioelectrical impedance spectroscopy at a frequency of 50 KHz. @entity1 was measured in serum and red blood cells (RBC) by atomic absorption spectrophotometry, and @entity1 in the diet was assessed from a 24-h diet record over a seven-day period, after an assessment of body composition. Mean PhA did not differ from M1 to M2. However, individual changes in PhA were positively associated with individual changes in serum (r  =  0.62, p  =  0.004) and RBC @entity1 (r  =  0.45, p  =  0.048). This association was independent of weight changes between assessments, but when adjusted for @entity1 intake changes, only the association between PhA and serum @entity1 remained significant. These results highlight that in elite athletes PhA may be an indirect indicator of muscular function.

title: XXXX and phase angle: a prognostic tool for monitoring cellular integrity in judo athletes.

answer: @entity0


abstract: @entity17 is a @entity16 caused by @entity18 that usually attacks mammals, such as @entity14 , @entity13 and @entity6 . The parasites can infect @entity0 via freshwater plants contaminated with encysted metacercariae. In the acute phase, which involves @entity2 , the disease may present with @entity12 , mild @entity4 and @entity8 . In the chronic phase, the parasites settle into the biliary tracts, and then cause @entity5 and @entity15 . Sometimes, the disease may mimic @entity1 , creating a mass appearance. Endoscopic retrograde cholangiopancreatography (ERCP) is an important diagnostic and treatment method because it allows simultaneous diagnosis and treatment. Here, we present a 44-year-old female @entity0 who presented to our hospital with complaints of @entity12 , @entity9 , @entity10 , @entity11 and @entity7 . After diagnostic investigations with laboratory and imaging methods, she was initially hospitalized with a preliminary diagnosis of @entity3 ( @entity3 ). However, after a full work-up, the @entity0 was diagnosed with @entity18 via ERCP and parasites were extracted with ERCP at the same time and then treated with a single dose of @entity19 10 mg/kg. Two months later, the clinical status of the @entity0 had improved markedly, with resolution of all symptoms and all laboratory and imaging tests returning to within normal limits.

title: An incidental case of XXXX mimicking @entity3 .

answer: @entity17


abstract: @entity17 is a @entity16 caused by @entity18 that usually attacks mammals, such as @entity14 , @entity13 and @entity6 . The parasites can infect @entity0 via freshwater plants contaminated with encysted metacercariae. In the acute phase, which involves @entity2 , the disease may present with @entity12 , mild @entity4 and @entity8 . In the chronic phase, the parasites settle into the biliary tracts, and then cause @entity5 and @entity15 . Sometimes, the disease may mimic @entity1 , creating a mass appearance. Endoscopic retrograde cholangiopancreatography (ERCP) is an important diagnostic and treatment method because it allows simultaneous diagnosis and treatment. Here, we present a 44-year-old female @entity0 who presented to our hospital with complaints of @entity12 , @entity9 , @entity10 , @entity11 and @entity7 . After diagnostic investigations with laboratory and imaging methods, she was initially hospitalized with a preliminary diagnosis of @entity3 ( @entity3 ). However, after a full work-up, the @entity0 was diagnosed with @entity18 via ERCP and parasites were extracted with ERCP at the same time and then treated with a single dose of @entity19 10 mg/kg. Two months later, the clinical status of the @entity0 had improved markedly, with resolution of all symptoms and all laboratory and imaging tests returning to within normal limits.

title: An incidental case of @entity17 mimicking XXXX .

answer: @entity3


abstract: The construction of a transcriptional map for @entity0 chromosome 21 requires the generation of a specific catalogue of genes, together with corresponding mapping information. Towards this goal, we conducted a pilot study on a pool of random chromosome 21 cosmids representing 2 Mb of non-contiguous DNA. Exon-amplification and cDNA selection methods were used in combination to extract the coding content from these cosmids, and to derive expressed sequences libraries. These libraries and the source cosmid library were arrayed at high density for hybridisation screening. A strategy was used which related data obtained by multiple hybridisations of clones originating from one library, screened against the other libraries. In this way, it was possible to integrate the information with the physical map and to compare the gene recovery rate of each technique. cDNAs and exons were grouped into bins delineated by EcoRI cosmid fragments, and a subset of 91 cDNAs and 29 exons have been sequenced. These sequences defined 79 non-overlapping potential coding segments distributed in 24 transcriptional units, which were mapped along 21q. Northern blot analysis performed for a subset of cDNAs indicated the existence of a cognate transcript. Comparison to databases indicated three segments matching to known chromosome 21 genes: @entity9 , @entity8 and @entity6 and six segments matching to unmapped anonymous expressed sequence tags (ESTs). At the translated @entity1 level, strong homologies to known proteins were found with @entity2 -binding transporters of the ABC family and the dihydroorotase domain of @entity7 synthetases. These data strongly suggest that bona fide partial genes have been isolated. Several of the newly isolated transcriptional units map to clinically important regions, in particular those involved in @entity4 , progressive @entity5 and @entity3 . The study presented here illustrates the complementarity of exon-amplification and cDNA selection techniques for generating a large resource of new expressed landmarks, which contribute to the construction of a chromosome 21 transcript map.

title: Model for a transcript map of XXXX chromosome 21: isolation of new coding sequences from exon and enriched cDNA libraries.

answer: @entity0


abstract: BACKGROUND:    Acute @entity7 frequently causes @entity0 hospitalization. Studies on different viruses or viral genomic load and disease severity or treatment effect have had conflicting results. We aimed to investigate whether the presence or concentration of individual or multiple viruses were associated with disease severity in @entity3 and to evaluate whether detected viruses modified the response to inhaled racemic @entity5 . METHODS:    Nasopharyngeal aspirates were collected from 363 @entity0 with @entity3 in a randomized, controlled trial that compared inhaled racemic @entity5 versus saline. Virus genome was identified and quantified by polymerase chain reaction analyses. Severity was assessed on the basis of the length of stay and the use of supportive care. RESULTS:    @entity8 (83%) and @entity0 rhinovirus (34%) were most commonly detected. Seven other viruses were present in 8%-15% of the @entity0 . Two or more viruses (maximum, 7) were detected in 61% of the @entity0 . @entity4 was not associated with disease severity. A high genomic load of @entity8 was associated with a longer length of stay and with an increased frequency of @entity1 and ventilatory support use. Treatment effect of inhaled @entity5 was not modified by virus type, load or @entity2 . DISCUSSION:    In @entity0 hospitalized with @entity3 , disease severity was not associated with specific viruses or the total number of viruses detected. A high @entity6 genomic load was associated with more-severe disease. CLINICAL TRIALS REGISTRATION:    NCT00817466 and EudraCT 2009-012667-34.

title: Virus Type and Genomic Load in Acute XXXX : Severity and Treatment Response With Inhaled @entity5 .

answer: @entity7


abstract: BACKGROUND:    Acute @entity7 frequently causes @entity0 hospitalization. Studies on different viruses or viral genomic load and disease severity or treatment effect have had conflicting results. We aimed to investigate whether the presence or concentration of individual or multiple viruses were associated with disease severity in @entity3 and to evaluate whether detected viruses modified the response to inhaled racemic @entity5 . METHODS:    Nasopharyngeal aspirates were collected from 363 @entity0 with @entity3 in a randomized, controlled trial that compared inhaled racemic @entity5 versus saline. Virus genome was identified and quantified by polymerase chain reaction analyses. Severity was assessed on the basis of the length of stay and the use of supportive care. RESULTS:    @entity8 (83%) and @entity0 rhinovirus (34%) were most commonly detected. Seven other viruses were present in 8%-15% of the @entity0 . Two or more viruses (maximum, 7) were detected in 61% of the @entity0 . @entity4 was not associated with disease severity. A high genomic load of @entity8 was associated with a longer length of stay and with an increased frequency of @entity1 and ventilatory support use. Treatment effect of inhaled @entity5 was not modified by virus type, load or @entity2 . DISCUSSION:    In @entity0 hospitalized with @entity3 , disease severity was not associated with specific viruses or the total number of viruses detected. A high @entity6 genomic load was associated with more-severe disease. CLINICAL TRIALS REGISTRATION:    NCT00817466 and EudraCT 2009-012667-34.

title: Virus Type and Genomic Load in Acute @entity7 : Severity and Treatment Response With Inhaled XXXX .

answer: @entity5


abstract: OBJECTIVES: The multidisciplinary clinic (MDC) has become the standard of care for individuals with @entity1 ( @entity1 ) in the United States, yet many @entity0 choose not to receive care at MDCs. We undertook a qualitative study of individuals with @entity1 to explore @entity0 ' perceptions of this form of service delivery. METHODS: @entity0 completed an online survey that posed open-ended questions about their attitudes and behaviors surrounding MCDs. Qualitative analysis was performed whereby response data was evaluated and grouped into themes. RESULTS: The unique aspect of MDCs most commonly cited by @entity0 was integrated care. Other reasons for attending MDC included those common to specialist centers, such as expertise, access to clinical trials, and participation in research. Perceived disadvantages unique to the MDC model were long and tiring visits. In common with many specialist centers, long travel times were cited as a disadvantage of MDCs. CONCLUSIONS: This information provides a foundation for improving @entity1 care. For those able to travel, the MDC model has much to offer, but @entity0 ' time should be respected. For those @entity0 who cannot travel, alternative models of care should be devised to provide integrated care, clinical expertise, and access to research.

title: A Qualitative Study of XXXX Clinic Use in the United States.

answer: @entity1


abstract: AIMS: Calcific @entity5 ( @entity5 ) is purportedly associated with less @entity4 burden in @entity0 than in @entity0 . We sought to examine sex-related differences and correlates of surgically excised aortic valve weight (AVW) in pure @entity5 . METHODS AND RESULTS: Clinical and echocardiographic characteristics of 888 consecutive @entity0 who underwent aortic valve replacement for severe @entity5 were correlated to AVW, and in 126 @entity0 , AVW was also correlated to computed tomography aortic valve @entity4 (AVC) score. @entity0 and @entity0 had similar indexed valve area (0.42    0.09 vs. 0.42    0.07 cm (2)/m(2), P = 0.95) and mean systolic gradient (53    15 vs. 52    13 mmHg, P = 0.11), but @entity0 had higher New York Heart Association class (2.63    0.70 vs. 2.50    0.70, P = 0.01) and less prevalent @entity3 (38 vs. 52%, P < 0.0001). Aortic valve weight was lower in @entity0 (1.94    0.88 vs. 3.08    1.32 g, P < 0.0001) even when indexed to body surface area (1.09    0.48 vs. 1.48    0.62 g/m(2), P < 0.0001) or left ventricular outflow tract (LVOT) area (0.54    0.23 vs. 0.71    0.29 g/cm(2), P < 0.0001). Using multivariate analysis, male sex (P < 0.0001), bicuspid valve (P < 0.0001), and larger LVOT area (P < 0.0001) were the major determinants of increased AVW, along with current cigarette smoking (P = 0.007). @entity1 (P = 0.004) and @entity2 (P = 0.03) were independently associated with lower AVW. Aortic valve @entity4 correlated well with AVW (r = 0.81, P < 0.0001) and was lower in @entity0 than in @entity0 (2520    1199 vs. 3606    1632 arbitrary units, P < 0.0001). CONCLUSIONS: Despite the same degree of @entity5 severity, @entity0 have less AVC and lower AVW compared with @entity0 , irrespective of valve morphology. Aortic valve @entity4 is correlated to excised AVW. @entity2 , @entity1 , and current cigarette smoking were independently associated with AVW.

title: Sex-related differences in calcific aortic stenosis: correlating clinical and echocardiographic characteristics and computed tomography aortic valve XXXX score to excised aortic valve weight.

answer: @entity4


abstract: AIMS: The right ventricle (RV) remodels early after @entity3 ( @entity3 ) in @entity2 ( @entity2 ) @entity0 . Previously reported preoperative thresholds to achieve early postoperative RV normalization were consistently close to 80 mL/m(2) for end-systolic volume ( @entity6 ) and 160 mL/m(2) for end-diastolic volume (EDV). Our objective was to determine whether these thresholds were also associated with mid-to-late RV normalization and clinical events. METHODS AND RESULTS: Out of a multicentre cohort of 157 @entity2 @entity0 who had undergone @entity3 , in 65 @entity0 (62% male, age 29    8 years, homograft in 98%) cardiovascular magnetic resonance (CMR) imaging was performed preoperatively and >3 years (6.3 years, interquartile range: 4.9-9.5) postoperatively. Mid-to-late haemodynamic outcome was classified as: 'RV normalization' [RV ejection fraction (EF) > 48% and RV EDV < 108 mL/m(2)] in 14 of 65 (22%) @entity0 , 'intermediate' in 34 of 65 (52%) @entity0 , and 'suboptimal' (RV EF < 45% and RV EDV > 120 mL/m(2)) in 17 of 65 (26%) @entity0 . Preoperative RV @entity6 < 80 mL/m(2) was strongly associated with favourable mid-to-late haemodynamic outcome in a proportional odds model [common odds ratio (OR): 0.04 for worse class, 95% confidence interval (CI): 0.01-0.17]. During 7.8    4.0 years follow-up after @entity3 , adverse clinical events ( @entity1 , sustained @entity5 , or @entity4 ) occurred in 18 of 106 (17%) @entity0 with preoperative CMR available. @entity0 with preoperative RV @entity6 > 95 mL/m(2) were at increased risk for unfavourable mid-to-late haemodynamic outcome (common OR: 25.5, 95% CI: 5.35-122) and events (hazard ratio: 2.89, 95% CI: 1.03-8.11). CONCLUSION: In @entity2 @entity0 who had undergone @entity3 , the best preoperative threshold to achieve mid-to-late RV normalization was RV @entity6 < 80 mL/m(2). @entity0 with preoperative RV @entity6 > 95 mL/m(2) were at increased risk for suboptimal haemodynamic outcome and adverse clinical events. Our findings may assist in timing of @entity3 .

title: Preoperative thresholds for mid-to-late haemodynamic and clinical outcomes after @entity3 in XXXX .

answer: @entity2


abstract: AIMS: The right ventricle (RV) remodels early after @entity3 ( @entity3 ) in @entity2 ( @entity2 ) @entity0 . Previously reported preoperative thresholds to achieve early postoperative RV normalization were consistently close to 80 mL/m(2) for end-systolic volume ( @entity6 ) and 160 mL/m(2) for end-diastolic volume (EDV). Our objective was to determine whether these thresholds were also associated with mid-to-late RV normalization and clinical events. METHODS AND RESULTS: Out of a multicentre cohort of 157 @entity2 @entity0 who had undergone @entity3 , in 65 @entity0 (62% male, age 29    8 years, homograft in 98%) cardiovascular magnetic resonance (CMR) imaging was performed preoperatively and >3 years (6.3 years, interquartile range: 4.9-9.5) postoperatively. Mid-to-late haemodynamic outcome was classified as: 'RV normalization' [RV ejection fraction (EF) > 48% and RV EDV < 108 mL/m(2)] in 14 of 65 (22%) @entity0 , 'intermediate' in 34 of 65 (52%) @entity0 , and 'suboptimal' (RV EF < 45% and RV EDV > 120 mL/m(2)) in 17 of 65 (26%) @entity0 . Preoperative RV @entity6 < 80 mL/m(2) was strongly associated with favourable mid-to-late haemodynamic outcome in a proportional odds model [common odds ratio (OR): 0.04 for worse class, 95% confidence interval (CI): 0.01-0.17]. During 7.8    4.0 years follow-up after @entity3 , adverse clinical events ( @entity1 , sustained @entity5 , or @entity4 ) occurred in 18 of 106 (17%) @entity0 with preoperative CMR available. @entity0 with preoperative RV @entity6 > 95 mL/m(2) were at increased risk for unfavourable mid-to-late haemodynamic outcome (common OR: 25.5, 95% CI: 5.35-122) and events (hazard ratio: 2.89, 95% CI: 1.03-8.11). CONCLUSION: In @entity2 @entity0 who had undergone @entity3 , the best preoperative threshold to achieve mid-to-late RV normalization was RV @entity6 < 80 mL/m(2). @entity0 with preoperative RV @entity6 > 95 mL/m(2) were at increased risk for suboptimal haemodynamic outcome and adverse clinical events. Our findings may assist in timing of @entity3 .

title: Preoperative thresholds for mid-to-late haemodynamic and clinical outcomes after XXXX in @entity2 .

answer: @entity3


abstract: BACKGROUND AND PURPOSE: Administering postoperative radiotherapy (PORT) is associated with improved survival and slower disease progression in select @entity2 @entity0 . Predictive factors for PORT refusal have not been described in this population. MATERIALS AND METHODS: Retrospective analysis of 6127 @entity2 @entity0 who received or refused PORT in the National @entity1 Database (2003-2006) was performed. Statistical analysis included Chi-square, multivariable logistic regression, Kaplan-Meier, and Cox proportional hazards analysis. RESULTS: In total, 247 @entity0 (4.0%) refused PORT. Three-year overall survival was 62.8% versus 53.4% for those who received and refused PORT, respectively. PORT refusers were more likely to have negative nodes than those who underwent PORT (37.4% versus 20.1%, p<.001). In multivariate analysis, predictive factors for refusing PORT included living far from the treatment facility (OR 1.92), having negative nodes (OR 2.14), and Charlson score of    2 (OR 2.14) (all p   .001). PORT refusal was associated with increased mortality (hazard ratio 1.20, p=.044). CONCLUSIONS: A significant proportion of @entity2 @entity0 refused PORT; this was associated with compromised overall survival. Predictive factors for PORT refusal included socioeconomic, demographic, and pathologic variables. Elucidating root causes of refusal may lead to interventions that improve long-term outcomes.

title: Refusal of postoperative radiotherapy and its association with survival in XXXX .

answer: @entity2


abstract: BACKGROUND _ AIMS: Ghrelin is a gastric hormone circulating in acylated (AG) and unacylated (UG) forms, and higher plasma @entity2 ( @entity2 ) and UG may be cross-sectionally associated with lower @entity3 resistance in @entity1 @entity0 . The potential value of ghrelin forms in predicting @entity3 resistance and its time-related changes in community-based population cohorts remains unknown. METHODS: We measured @entity2 , AG and calculated UG ( @entity2 -AG) in 716 individuals from the North-East-Italy MoMa study (age: 55      9 years, BMI: 29      5  kg/m(2), M/F:349/367) to test the hypothesis that circulating @entity2 and UG, but not AG are negatively associated with @entity3 resistance (HOMA). We further hypothesized that baseline @entity2 and UG negatively predict 5-year HOMA changes in a 350-individual subgroup. RESULTS: Baseline @entity2 and UG were associated negatively with HOMA after adjusting for gender and body mass index (BMI). Baseline gender- and BMI-adjusted @entity2 and UG were also negatively associated with HOMA at 5-year follow-up (n  =  350), and changes in @entity2 and UG were negatively associated with changes in HOMA (P  <  0.05) after adjustment for anthropometric and metabolic confounders. No statistically significant correlations were observed between AG and baseline or 5-year HOMA. CONCLUSIONS: In a North-East Italy community-based population cohort, plasma @entity2 and UG but not AG are negatively associated with HOMA. @entity2 and UG and their changes also independently predict 5-year HOMA changes. @entity2 and UG are therefore novel potential modulators of @entity3 resistance and may contribute to predict its time-related changes in @entity0 .

title: Plasma total and unacylated ghrelin predict 5-year changes in XXXX resistance.

answer: @entity3


abstract: IMPORTANCE: Detecting progression of @entity1 is often challenging. OBJECTIVE: To test the feasibility of using frequency-domain optical coherence tomography (FD-OCT) and a region-of-interest (ROI) approach to measure progressive changes in @entity1 . DESIGN, SETTING, AND @entity0 : Among a group of @entity0 in an institutional @entity3 practice who were likely to show @entity3 progression, eyes with a history of an @entity2 ( @entity2 ) confirmed by stereophotography were followed up with FD-OCT cube scans of the optic disc. All @entity0 underwent FD-OCT scans on at least 2 occasions separated by at least 1 year (mean, 3.45 years; range, 1.42-6.39 years). Because we were not studying the effects of an optic @entity2 , no constraint was placed on the time between the documentation of an optic @entity2 and the first scan used in the analysis. MAIN OUTCOMES AND MEASURES: After en face images of the FD-OCT scan were aligned based on the blood vessels, circumpapillary images were derived for an annulus 100   m in width, and the retinal nerve fiber layer (RNFL) thickness profiles were plotted for the first and last visits. The ROI width associated with the optic @entity2 was defined as the region of the RNFL profile below the 1% CI based on healthy norms. The change in the ROI width was compared with the change in the global RNFL thickness, which was obtained by averaging the circumpapillary RNFL thickness. RESULTS: The change in the ROI width (mean [SD], 8.0   [6.4  ]; 95% CI, 4.9   to 11.1  ; range, -0.7   to 19.3  ) was significant (P   <   .001, 2-tailed t test) while the change in the global thickness (mean [SD], 2.40 [5.87]  m; 95% CI, -0.48 to 5.28  m) was not significant (P   >   .12, 2-tailed t test). Although 15 of the 16 ROIs increased in width between visits, only 11 showed a decrease in the global RNFL thickness. CONCLUSIONS AND RELEVANCE: For detecting progression of local RNFL damage in @entity0 with @entity3 , an OCT ROI approach appears superior to the OCT global RNFL thickness measure typically used.

title: A Region-of-Interest Approach for Detecting Progression of XXXX With Optical Coherence Tomography.

answer: @entity1


abstract: OBJECTIVES/HYPOTHESIS: To evaluate the short-term voice outcomes of vocal fold augmentation using fat compared to calcium hydroxylapatite product Radiesse Voice (Merz Aesthetics). STUDY DESIGN: Retrospective study design. METHODS: Sixty-six consecutive @entity0 with @entity3 were recruited, including the final 33 @entity0 treated with fat and all 33 @entity0 treated with calcium hydroxylapatite product. Before April 2011, fat augmentation was the standard treatment; from April 2011, only @entity1 hydroxylapatite product was used. For all subjects, videolaryngostroboscopic evaluation, s/z ratios, and @entity2 index (VHI) were analyzed. METHODS: Treatment outcomes were evaluated 3 months after the augmentation. Two @entity0 augmented with fat (both after 6 months), versus four augmented with @entity1 hydroxylapatite product (mean after 7 months), needed reintervention. Mean VHI decreased from 18 points in the fat augmentation group compared to 17 points in the @entity1 hydroxylapatite group. Mean s/z ratio changed -0.33 in the fat augmentation group compared to -0.46 in the @entity1 hydroxylapatite group. CONCLUSION: This retrospective cohort demonstrates that there are no short-term differences in VHI outcome or number of reinterventions for augmentation with fat compared to calcium hydroxylapatite product Radiesse Voice (Merz Aesthetics). LEVEL OF EVIDENCE: Level 4. Laryngoscope, 2014.

title: Comparison of voice outcome after vocal fold augmentation with fat or XXXX hydroxylapatite.

answer: @entity1


abstract: The ability of small @entity5 -positive (SACHE) cells to incorporate tritiated @entity4 ( @entity1 ) was studied in the bone marrow of @entity0 made acutely @entity2 by injection of guinea pig antimouse platelet serum (APS) and in control @entity0 injected with normal guinea pig serum (NS). @entity1 was administered in vivo, and bone marrow was collected at various time points thereafter. The initial @entity3 ( @entity3 ) for both groups was about 30%. After four hours, the @entity3 increased and reached peak values at 48 hours, but was lower in @entity2 animals. The lower peak @entity3 in APS-treated animals may be the result of both a faster rate of influx of unlabeled cells into the @entity5 ( @entity5 ) positive cell compartment and efflux of more heavily labeled, and probably polyploid, SACHE cells into the compartment of recognizable megakaryocytes. In both groups the increasing @entity3 occurred concomitantly with a decreasing mean grain count. This may indicate cellular division by some fraction of SACHE cells. Heterogeneity in nuclear morphology was also demonstrated, and the frequency of individual morphologies was altered in APS-treated animals. In addition, cells that incorporated @entity1 were larger than those that did not. This group of small cells appears to represent a pivotal point in megakaryocytopoiesis in which the switch from mitosis to endomitosis is occurring.

title: Megakaryocytopoiesis: incorporation of tritiated @entity4 by small XXXX -positive cells in @entity0 bone marrow during antibody-induced @entity2 .

answer: @entity5


abstract: The ability of small @entity5 -positive (SACHE) cells to incorporate tritiated @entity4 ( @entity1 ) was studied in the bone marrow of @entity0 made acutely @entity2 by injection of guinea pig antimouse platelet serum (APS) and in control @entity0 injected with normal guinea pig serum (NS). @entity1 was administered in vivo, and bone marrow was collected at various time points thereafter. The initial @entity3 ( @entity3 ) for both groups was about 30%. After four hours, the @entity3 increased and reached peak values at 48 hours, but was lower in @entity2 animals. The lower peak @entity3 in APS-treated animals may be the result of both a faster rate of influx of unlabeled cells into the @entity5 ( @entity5 ) positive cell compartment and efflux of more heavily labeled, and probably polyploid, SACHE cells into the compartment of recognizable megakaryocytes. In both groups the increasing @entity3 occurred concomitantly with a decreasing mean grain count. This may indicate cellular division by some fraction of SACHE cells. Heterogeneity in nuclear morphology was also demonstrated, and the frequency of individual morphologies was altered in APS-treated animals. In addition, cells that incorporated @entity1 were larger than those that did not. This group of small cells appears to represent a pivotal point in megakaryocytopoiesis in which the switch from mitosis to endomitosis is occurring.

title: Megakaryocytopoiesis: incorporation of tritiated @entity4 by small @entity5 -positive cells in @entity0 bone marrow during antibody-induced XXXX .

answer: @entity2


abstract: The ability of small @entity5 -positive (SACHE) cells to incorporate tritiated @entity4 ( @entity1 ) was studied in the bone marrow of @entity0 made acutely @entity2 by injection of guinea pig antimouse platelet serum (APS) and in control @entity0 injected with normal guinea pig serum (NS). @entity1 was administered in vivo, and bone marrow was collected at various time points thereafter. The initial @entity3 ( @entity3 ) for both groups was about 30%. After four hours, the @entity3 increased and reached peak values at 48 hours, but was lower in @entity2 animals. The lower peak @entity3 in APS-treated animals may be the result of both a faster rate of influx of unlabeled cells into the @entity5 ( @entity5 ) positive cell compartment and efflux of more heavily labeled, and probably polyploid, SACHE cells into the compartment of recognizable megakaryocytes. In both groups the increasing @entity3 occurred concomitantly with a decreasing mean grain count. This may indicate cellular division by some fraction of SACHE cells. Heterogeneity in nuclear morphology was also demonstrated, and the frequency of individual morphologies was altered in APS-treated animals. In addition, cells that incorporated @entity1 were larger than those that did not. This group of small cells appears to represent a pivotal point in megakaryocytopoiesis in which the switch from mitosis to endomitosis is occurring.

title: Megakaryocytopoiesis: incorporation of tritiated XXXX by small @entity5 -positive cells in @entity0 bone marrow during antibody-induced @entity2 .

answer: @entity4


abstract: The ability of small @entity5 -positive (SACHE) cells to incorporate tritiated @entity4 ( @entity1 ) was studied in the bone marrow of @entity0 made acutely @entity2 by injection of guinea pig antimouse platelet serum (APS) and in control @entity0 injected with normal guinea pig serum (NS). @entity1 was administered in vivo, and bone marrow was collected at various time points thereafter. The initial @entity3 ( @entity3 ) for both groups was about 30%. After four hours, the @entity3 increased and reached peak values at 48 hours, but was lower in @entity2 animals. The lower peak @entity3 in APS-treated animals may be the result of both a faster rate of influx of unlabeled cells into the @entity5 ( @entity5 ) positive cell compartment and efflux of more heavily labeled, and probably polyploid, SACHE cells into the compartment of recognizable megakaryocytes. In both groups the increasing @entity3 occurred concomitantly with a decreasing mean grain count. This may indicate cellular division by some fraction of SACHE cells. Heterogeneity in nuclear morphology was also demonstrated, and the frequency of individual morphologies was altered in APS-treated animals. In addition, cells that incorporated @entity1 were larger than those that did not. This group of small cells appears to represent a pivotal point in megakaryocytopoiesis in which the switch from mitosis to endomitosis is occurring.

title: Megakaryocytopoiesis: incorporation of tritiated @entity4 by small @entity5 -positive cells in XXXX bone marrow during antibody-induced @entity2 .

answer: @entity0


abstract: OBJECTIVE: To investigate the effect of serum @entity2 (E2) levels on the day of @entity0 chorionic gonadotropin ( @entity4 ) administration on the outcome of controlled @entity1 (COH) in both long @entity5 ( @entity3 ) agonist and @entity3 antagonist protocols. MATERIALS AND METHODS: This study included 212 in vitro fertilization-embryo transfer (IVF-ET) cycles performed with either long @entity3 agonist or @entity3 antagonist protocols were classified into three groups according to serum E2 levels measured on the day of @entity4 injection: < 2,000 pg/ml, 2,000-4,000 pg/ml, and > 4,000 pg/ml. The three groups were compared according to age, number of retrieved oocytes, number of transferred embryos, and pregnancy rates for each of the stimulation protocols. RESULTS: The long and antagonist protocols were performed in 130 and 82 cycles, respectively. The pregnancy rates were 21.5% (28/130) and 23.2% (19/82) in the long- and antagonist-protocol groups, respectively. Serum E2 levels were measured on the day of @entity4 administration as < 2,000 pg/ml in 65 cycles, 2,000-4,000 pg/ml in 76 cycles, and > 4,000 pg/ml in 71 cycles. The number of retrieved oocytes increased in parallel to serum E2 levels (p = 0.001). However, there was no significant difference among groups in the pregnancy rates (p = 0.116). Similarly, the number of retrieved oocytes increased in parallel to serum E2 levels in both of the protocol groups (p value was 0.001 in both long @entity3 agonist and antagonist protocols), but there was no correlation between the pregnancy rates and serum E2 levels (p value of long @entity3 agonist protocol was 0.254 and thep value of antagonist group was 0.349). CONCLUSION: The serum E2 level on the day of @entity4 administration does not predict the pregnancy outcome in IVF with either long @entity3 agonist or @entity3 antagonist protocols.

title: Does the XXXX level on the day of @entity0 chorionic gonadotropin administration predict the clinical outcome of controlled @entity1 ?

answer: @entity2


abstract: OBJECTIVE: To investigate the effect of serum @entity2 (E2) levels on the day of @entity0 chorionic gonadotropin ( @entity4 ) administration on the outcome of controlled @entity1 (COH) in both long @entity5 ( @entity3 ) agonist and @entity3 antagonist protocols. MATERIALS AND METHODS: This study included 212 in vitro fertilization-embryo transfer (IVF-ET) cycles performed with either long @entity3 agonist or @entity3 antagonist protocols were classified into three groups according to serum E2 levels measured on the day of @entity4 injection: < 2,000 pg/ml, 2,000-4,000 pg/ml, and > 4,000 pg/ml. The three groups were compared according to age, number of retrieved oocytes, number of transferred embryos, and pregnancy rates for each of the stimulation protocols. RESULTS: The long and antagonist protocols were performed in 130 and 82 cycles, respectively. The pregnancy rates were 21.5% (28/130) and 23.2% (19/82) in the long- and antagonist-protocol groups, respectively. Serum E2 levels were measured on the day of @entity4 administration as < 2,000 pg/ml in 65 cycles, 2,000-4,000 pg/ml in 76 cycles, and > 4,000 pg/ml in 71 cycles. The number of retrieved oocytes increased in parallel to serum E2 levels (p = 0.001). However, there was no significant difference among groups in the pregnancy rates (p = 0.116). Similarly, the number of retrieved oocytes increased in parallel to serum E2 levels in both of the protocol groups (p value was 0.001 in both long @entity3 agonist and antagonist protocols), but there was no correlation between the pregnancy rates and serum E2 levels (p value of long @entity3 agonist protocol was 0.254 and thep value of antagonist group was 0.349). CONCLUSION: The serum E2 level on the day of @entity4 administration does not predict the pregnancy outcome in IVF with either long @entity3 agonist or @entity3 antagonist protocols.

title: Does the @entity2 level on the day of @entity0 chorionic gonadotropin administration predict the clinical outcome of controlled XXXX ?

answer: @entity1


abstract: OBJECTIVE: To investigate the effect of serum @entity2 (E2) levels on the day of @entity0 chorionic gonadotropin ( @entity4 ) administration on the outcome of controlled @entity1 (COH) in both long @entity5 ( @entity3 ) agonist and @entity3 antagonist protocols. MATERIALS AND METHODS: This study included 212 in vitro fertilization-embryo transfer (IVF-ET) cycles performed with either long @entity3 agonist or @entity3 antagonist protocols were classified into three groups according to serum E2 levels measured on the day of @entity4 injection: < 2,000 pg/ml, 2,000-4,000 pg/ml, and > 4,000 pg/ml. The three groups were compared according to age, number of retrieved oocytes, number of transferred embryos, and pregnancy rates for each of the stimulation protocols. RESULTS: The long and antagonist protocols were performed in 130 and 82 cycles, respectively. The pregnancy rates were 21.5% (28/130) and 23.2% (19/82) in the long- and antagonist-protocol groups, respectively. Serum E2 levels were measured on the day of @entity4 administration as < 2,000 pg/ml in 65 cycles, 2,000-4,000 pg/ml in 76 cycles, and > 4,000 pg/ml in 71 cycles. The number of retrieved oocytes increased in parallel to serum E2 levels (p = 0.001). However, there was no significant difference among groups in the pregnancy rates (p = 0.116). Similarly, the number of retrieved oocytes increased in parallel to serum E2 levels in both of the protocol groups (p value was 0.001 in both long @entity3 agonist and antagonist protocols), but there was no correlation between the pregnancy rates and serum E2 levels (p value of long @entity3 agonist protocol was 0.254 and thep value of antagonist group was 0.349). CONCLUSION: The serum E2 level on the day of @entity4 administration does not predict the pregnancy outcome in IVF with either long @entity3 agonist or @entity3 antagonist protocols.

title: Does the @entity2 level on the day of XXXX chorionic gonadotropin administration predict the clinical outcome of controlled @entity1 ?

answer: @entity0


abstract: OBJECTIVE: To discuss the clinical significance of the @entity2 for femoral lesser trochanteric fragment in treating the femoral comminuted intertrochanteric @entity1 . METHODS: From January 2012 to December 2013,32 @entity0 with intertrochanteric @entity1 were treated by surgery, and self-designed reduction fixators were used in the @entity0 for the fixation of @entity3 . There were 11 males and 21 females, ranging in age from 45 to 81 years old with an average of 64 years old. According to the Evans typing, 12 cases were type II, 13 cases were type III and 7 cases were type IV. Simple lag screw fixed in 19 cases and steel wire fixed in 13 cases. Hip joint function was evaluated according Harris score and the complications such as coxa adducta,cutting of femoral head and neck,implants breakage were observed. RESULTS: Thirty-two @entity0 were followed up from 9 to 24 months with an average of 13 months. Coxa adducta occurred in 1 case,no cutting of femoral head and neck occurred and implants breakage were found. The mean Harris score was 91.80    3.05 in 32 @entity0 . CONCLUSION: The reconstruction and fixation for the posterior medial bone cortex continuity is a key factor on affect the stability of femoral intertrochanteric @entity1 . Self-designed reduction fixators can effective reduce and fix the @entity3 , it has advantage of fast @entity2 , and simple operation.

title: [Design of the reduction fixator and its clinical application in treating @entity1 of XXXX ].

answer: @entity3


abstract: OBJECTIVE: To discuss the clinical significance of the @entity2 for femoral lesser trochanteric fragment in treating the femoral comminuted intertrochanteric @entity1 . METHODS: From January 2012 to December 2013,32 @entity0 with intertrochanteric @entity1 were treated by surgery, and self-designed reduction fixators were used in the @entity0 for the fixation of @entity3 . There were 11 males and 21 females, ranging in age from 45 to 81 years old with an average of 64 years old. According to the Evans typing, 12 cases were type II, 13 cases were type III and 7 cases were type IV. Simple lag screw fixed in 19 cases and steel wire fixed in 13 cases. Hip joint function was evaluated according Harris score and the complications such as coxa adducta,cutting of femoral head and neck,implants breakage were observed. RESULTS: Thirty-two @entity0 were followed up from 9 to 24 months with an average of 13 months. Coxa adducta occurred in 1 case,no cutting of femoral head and neck occurred and implants breakage were found. The mean Harris score was 91.80    3.05 in 32 @entity0 . CONCLUSION: The reconstruction and fixation for the posterior medial bone cortex continuity is a key factor on affect the stability of femoral intertrochanteric @entity1 . Self-designed reduction fixators can effective reduce and fix the @entity3 , it has advantage of fast @entity2 , and simple operation.

title: [Design of the reduction fixator and its clinical application in treating XXXX of @entity3 ].

answer: @entity1


abstract: This study sought to characterize @entity0 with @entity8 seen at one tertiary referral center by reviewing medical records of @entity0 with a confirmed diagnosis between January 1, 1976 and September 1, 1992. One hundred sixty-five cases were identified. The mean age at diagnosis was 57 yr (SD 15). The female-to-male ratio was 1.1:1.0. Ninety-two percent of @entity0 were white. Seventy-seven percent of cases were unsuspected before diagnosis, and 16% were diagnosed at autopsy. The most common associated conditions were @entity2 , analgesic abuse, @entity7 , @entity1 , and @entity6 . There was considerable overlap in the presence of these conditions, with two or more identified in 36% of @entity0 . In addition, 11% of @entity0 had none of these well-recognized risks. Other diagnoses in this group included @entity3 , @entity5 , and @entity4 . A decline in case numbers of approximately 50% was demonstrated over the last 10 yr studied. This period was associated with a 57% reduction in the number of excretory urograms carried out, suggesting that changes in diagnostic imaging preference may have contributed. Vital status and renal outcome data after diagnosis were obtained in 93% of cases. Of those diagnosed while living, survival was lowest among @entity1 @entity0 . Ten-year survival for nondiabetics was not significantly different from the expected survival of an age- and sex-matched cohort. The overall risk for requiring renal replacement therapy after the diagnosis of @entity8 in surviving @entity0 was low (7% of 136 @entity0 at risk).(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX necrosis--a sixteen-year clinical experience.

answer: @entity8


abstract: BACKGROUND: Percutaneous (minimally invasive) suturing is a promising option for @entity6 ( @entity6 ) repair with low rerupture and infection rates. @entity2 are the major problem to avoid with the technique. A new device was therefore designed for suturing the @entity6 , resulting in channel-assisted minimally invasive repair (CAMIR). The purpose of this study was to compare the clinical and functional outcomes of CAMIR with traditional open techniques. METHOD: Eighty two @entity0 with @entity5 were included: 41 for CAMIR, 41 for open repair. All @entity0 followed a standardized rehabilitation protocol. Follow-ups were at 12 and 24  months after surgery. Functional evaluation was based on the clinical American Orthopaedic Foot _ Ankle Society score associated with @entity1 (sural nerve), @entity4 circumference, range of motion (ROM), and isometric testing. RESULTS: There was no difference between groups regarding plantar flexor strength, ankle ROM, or @entity4 circumference. CAMIR significantly decreased the operative time compared to open repair (17 vs. 56  min, P   <   0.0001). Mean scar length was greater in the open repair group (10 vs. 2  cm, P   <   0.0001). There were no wound complications in the CAMIR group but four in the open repair group (P   <   0.0001). No @entity7 , rerupture, or @entity3 occurred. CONCLUSION: CAMIR and open repair yielded essentially identical clinical and functional outcomes. @entity3 can be minimized using CAMIR by carefully placing the suture channel with a stab incision and special trocar based on a modified Bunnell suture technique.

title: Channel-assisted minimally invasive repair of acute XXXX .

answer: @entity5


abstract: OBJECTIVE: To report the type and prevalence of obstetric lacerations in a primigravid @entity0 population after term spontaneous vaginal delivery without episiotomy. We examined the characteristics of lacerations in @entity0 with postpartum @entity2 or @entity3 . STUDY DESIGN: This was a retrospective cohort of primiparous @entity0 who spontaneously delivered in the residents' service at a large urban hospital under the supervision of Ob/Gyn faculty. Data was extracted from medical records using discharge diagnosis codes. Postpartum medical records and diagnostic codes of all @entity0 with lacerations and postpartum @entity2 were reviewed. The study was IRB approved. RESULTS: A cohort of 1617 primiparous @entity0 with spontaneous vaginal delivery met the inclusion criteria. No tears were recorded in 836 @entity0 (51.7%), first-degree tears in 413 cases (25.5%), second-degree tears in 271 cases (16.8%), third-degree tears in 58 cases (3.6%), fourth-degree in 21 cases (1.3%), and 18 cases (1.1%) were not further classified. Only 51 @entity0 (3.2%) with first- and second-degree lacerations had postpartum complications, and merely 6 (0.4%) had @entity1 and 6 (0.4%) had @entity2 . However, 4 of those @entity0 (33.3%) required vulvoplasty for @entity2 . CONCLUSION: Almost half of @entity0 with spontaneous vaginal delivery without episiotomy experienced some @entity4 . A first degree was documented in >25% of cases; however, <10% of those subsequently had complaints of @entity1 or @entity2 .

title: XXXX and postpartum @entity2 .

answer: @entity4


abstract: OBJECTIVE: To report the type and prevalence of obstetric lacerations in a primigravid @entity0 population after term spontaneous vaginal delivery without episiotomy. We examined the characteristics of lacerations in @entity0 with postpartum @entity2 or @entity3 . STUDY DESIGN: This was a retrospective cohort of primiparous @entity0 who spontaneously delivered in the residents' service at a large urban hospital under the supervision of Ob/Gyn faculty. Data was extracted from medical records using discharge diagnosis codes. Postpartum medical records and diagnostic codes of all @entity0 with lacerations and postpartum @entity2 were reviewed. The study was IRB approved. RESULTS: A cohort of 1617 primiparous @entity0 with spontaneous vaginal delivery met the inclusion criteria. No tears were recorded in 836 @entity0 (51.7%), first-degree tears in 413 cases (25.5%), second-degree tears in 271 cases (16.8%), third-degree tears in 58 cases (3.6%), fourth-degree in 21 cases (1.3%), and 18 cases (1.1%) were not further classified. Only 51 @entity0 (3.2%) with first- and second-degree lacerations had postpartum complications, and merely 6 (0.4%) had @entity1 and 6 (0.4%) had @entity2 . However, 4 of those @entity0 (33.3%) required vulvoplasty for @entity2 . CONCLUSION: Almost half of @entity0 with spontaneous vaginal delivery without episiotomy experienced some @entity4 . A first degree was documented in >25% of cases; however, <10% of those subsequently had complaints of @entity1 or @entity2 .

title: @entity4 and postpartum XXXX .

answer: @entity2


abstract: Twenty-four @entity0 aged 3 months to 18 years (median, 12 years) were treated for @entity10 at the @entity0 's Hospital of Philadelphia Cancer Research Center from 1958 through 1984. Sixteen @entity0 had @entity9 ( @entity9 ). The @entity1 arose in an extremity or in the trunk (15 @entity0 ), the retroperitoneum-pelvis (6), or other sites (3). Twelve @entity0 underwent grossly complete excision of localized @entity4 ; of them, five had no known @entity2 and seven had proven microscopic @entity3 . Ten of the remaining 12 @entity0 had grossly visible, residual localized disease, and two had lung metastases. After operation, nine were treated on a protocol with local radiation therapy (4000-6000 rad) plus @entity7 , @entity8 , and @entity6 with or without @entity5 ( @entity5 ). The other 15 were treated variably. At 3 years, the proportion of @entity1 -free survivors was 9 of 24 (37.5%). The significant favorable factors were the initial surgical removal of all gross @entity1 (9 of 12 with @entity1 excision were @entity1 -free survivors at 3 years compared to none of 12 with gross residual @entity4 ; P less than 0.01), and a @entity1 mitotic rate under one per high-power field. No significant correlation was found between @entity1 -free survival expectancy and age, race, sex, the presence of @entity9 , the site and size of the @entity1 , or use of the chemoradiotherapy regimen. More effective treatment programs are needed for @entity0 with @entity10 , especially for those with unresectable @entity1 .

title: Treatment of @entity0 with XXXX . Experience at the @entity0 's Hospital of Philadelphia, 1958-1984.

answer: @entity10


abstract: Twenty-four @entity0 aged 3 months to 18 years (median, 12 years) were treated for @entity10 at the @entity0 's Hospital of Philadelphia Cancer Research Center from 1958 through 1984. Sixteen @entity0 had @entity9 ( @entity9 ). The @entity1 arose in an extremity or in the trunk (15 @entity0 ), the retroperitoneum-pelvis (6), or other sites (3). Twelve @entity0 underwent grossly complete excision of localized @entity4 ; of them, five had no known @entity2 and seven had proven microscopic @entity3 . Ten of the remaining 12 @entity0 had grossly visible, residual localized disease, and two had lung metastases. After operation, nine were treated on a protocol with local radiation therapy (4000-6000 rad) plus @entity7 , @entity8 , and @entity6 with or without @entity5 ( @entity5 ). The other 15 were treated variably. At 3 years, the proportion of @entity1 -free survivors was 9 of 24 (37.5%). The significant favorable factors were the initial surgical removal of all gross @entity1 (9 of 12 with @entity1 excision were @entity1 -free survivors at 3 years compared to none of 12 with gross residual @entity4 ; P less than 0.01), and a @entity1 mitotic rate under one per high-power field. No significant correlation was found between @entity1 -free survival expectancy and age, race, sex, the presence of @entity9 , the site and size of the @entity1 , or use of the chemoradiotherapy regimen. More effective treatment programs are needed for @entity0 with @entity10 , especially for those with unresectable @entity1 .

title: Treatment of XXXX with @entity10 . Experience at the @entity0 's Hospital of Philadelphia, 1958-1984.

answer: @entity0


abstract: Twenty-four @entity0 aged 3 months to 18 years (median, 12 years) were treated for @entity10 at the @entity0 's Hospital of Philadelphia Cancer Research Center from 1958 through 1984. Sixteen @entity0 had @entity9 ( @entity9 ). The @entity1 arose in an extremity or in the trunk (15 @entity0 ), the retroperitoneum-pelvis (6), or other sites (3). Twelve @entity0 underwent grossly complete excision of localized @entity4 ; of them, five had no known @entity2 and seven had proven microscopic @entity3 . Ten of the remaining 12 @entity0 had grossly visible, residual localized disease, and two had lung metastases. After operation, nine were treated on a protocol with local radiation therapy (4000-6000 rad) plus @entity7 , @entity8 , and @entity6 with or without @entity5 ( @entity5 ). The other 15 were treated variably. At 3 years, the proportion of @entity1 -free survivors was 9 of 24 (37.5%). The significant favorable factors were the initial surgical removal of all gross @entity1 (9 of 12 with @entity1 excision were @entity1 -free survivors at 3 years compared to none of 12 with gross residual @entity4 ; P less than 0.01), and a @entity1 mitotic rate under one per high-power field. No significant correlation was found between @entity1 -free survival expectancy and age, race, sex, the presence of @entity9 , the site and size of the @entity1 , or use of the chemoradiotherapy regimen. More effective treatment programs are needed for @entity0 with @entity10 , especially for those with unresectable @entity1 .

title: Treatment of @entity0 with @entity10 . Experience at the XXXX 's Hospital of Philadelphia, 1958-1984.

answer: @entity0


abstract: More than 1000 cells of a spontaneously transformed line of BALB/3T3 cells are required to initiate @entity0 in half the @entity1 inoculated s.c., although the cells clone with an efficiency approaching 100% in culture. The cells of two @entity0 with prolonged latent periods, initiated by 2 X 10(4) and 5 X 10(3) cells, were chosen for detailed clonal analysis in culture. The cells from the @entity0 grew very poorly in culture in the first passages, but with increasing speed and efficiency in later passages. Cells derived directly from the two @entity0 cloned in agar with an efficiency of 0.01 and 0.002%. The growth rates on plastic of the rare successful clones derived from agar were generally low but extremely varied. Some clones lost the capacity for multiplication in a few passages, while others persisted but fluctuated unpredictably in growth rate in the early passages. The graded increase in growth rate of the uncloned @entity0 cell populations was probably the result of selection of the more rapidly growing clones. One of the slower-growing clones was subcloned. About half of the subclones grew at a slower rate than the parental clone. These, however, increased progressively in growth rate over six successive weekly passages, suggesting the occurrence of a gradual physiological adaptation. We conclude that selection of fast-growing clones contributes a major part of the gradually improving growth of @entity0 cell populations in culture, but that a physiological adaptation extending over many cell generations makes a significant contribution. The mechanism in either case is unknown, and indeed there may not be a unique mechanism in the scientifically rigorous sense.

title: Selection and adaptation for rapid growth in culture of cells from delayed sarcomas in XXXX .

answer: @entity1