abstract: AIM: The objective of our study was to assess diagnostic value of three-dimensional (3D) vectorcardiographic (VCG) parameters in detecting @entity1 ( @entity1 ) in @entity2 ( @entity2 ) with and without @entity3 ( @entity3 ). METHODS: The study group of 62 @entity0 with @entity2 was stratified on the basis of color Doppler echocardiographic findings into three subgroups: non- @entity1 (n = 23), @entity1 without @entity3 (n = 22), and @entity1 with @entity3 (n = 17). Pairwise differences between the subgroups were evaluated by one-way analysis of variance, and Pearson correlation analysis was used to evaluate the significance of the correlations between pulmonary arterial systolic pressure (PASP) and various VCG parameters. RESULTS: The azimuth of the QRS vector decreased from -24   in the non- @entity1 group to -62   in @entity1 without @entity3 and to -140   in @entity1 with @entity3 (P < 0.01 for pairwise differences between all three groups). Similar significant decrease was observed for the azimuth of the ventricular gradient (VG) vector. Spatial QRS/ @entity4 increased from 69   in the non- @entity1 group to 115   in @entity1 without @entity3 (P < 0.01). In the @entity1 group with @entity3 , QRS/ @entity4 was 94   (P < 0.05 for difference from the non- @entity1 group). There was a significant correlation between PASP and QRS/ @entity4 (r = 0.89, P < 0.05) and between PASP and the azimuth of the VG vector (r = 0.86, P < 0.05). PASP increase from linear regression model was 0.8 mmHg for a QRS/ @entity4 increase by 10   and 1.3 mmHg for each 10   increase in the azimuth of the VG vector. CONCLUSION: 3DVCG parameters are potentially useful for predicting PASP in @entity2 @entity0 , and possibly also for differentiation between @entity2 @entity0 with @entity1 and @entity3 from those without @entity3 .

title: Prediction of Pulmonary Arterial Hypertension in XXXX from Three-Dimensional Vectorcardiographic Parameters.

answer: @entity2


abstract: BACKGROUND: The most common monogenic form of @entity1 is caused by mutations in the @entity4 ( @entity4 ) gene. More than 150 mutations have been reported in the @entity4 gene, the majority being point mutations. Most individuals with @entity4 gene mutations have early-onset @entity1 , @entity6 , and increased longitudinal growth. METHODS: A 9-year-old Caucasian @entity0 was referred to genetics for @entity1 , food-seeking behavior, and @entity3 . History and physical exam were not consistent with @entity5 , but revealed @entity2 . Owing to significant @entity1 and @entity6 , a @entity5 methylation test and a microarray were requested. RESULTS: Methlylation testing for @entity5 was normal. Microarray analysis revealed two changes: (1) A 2.6-Mb deletion at chromosome 18q21.31 was identified and contained several OMIM genes, including the @entity4 gene, and (2) an 0.87-Mb duplication at chromosome region 16p13.3 was found and contained one gene. Parental samples revealed that the @entity0 's father had the same deletion and duplication. This case appears to be the first with a deletion of 18q21.31 encompassing the @entity4 gene presenting with features of @entity6 and @entity1 . CONCLUSIONS: Haploinsufficiency of the @entity4 gene either through whole gene deletion or nonsense or missense mutations is associated with a significant risk of @entity1 . The case emphasizes both the role of the @entity4 gene in @entity1 as well as the importance of looking for chromosomal microdeletions/duplications as a cause of @entity1 in @entity0 with @entity2 or @entity3 .

title: Deletion of the XXXX Gene in a 9-Year-Old Obese @entity0 .

answer: @entity4


abstract: BACKGROUND: The most common monogenic form of @entity1 is caused by mutations in the @entity4 ( @entity4 ) gene. More than 150 mutations have been reported in the @entity4 gene, the majority being point mutations. Most individuals with @entity4 gene mutations have early-onset @entity1 , @entity6 , and increased longitudinal growth. METHODS: A 9-year-old Caucasian @entity0 was referred to genetics for @entity1 , food-seeking behavior, and @entity3 . History and physical exam were not consistent with @entity5 , but revealed @entity2 . Owing to significant @entity1 and @entity6 , a @entity5 methylation test and a microarray were requested. RESULTS: Methlylation testing for @entity5 was normal. Microarray analysis revealed two changes: (1) A 2.6-Mb deletion at chromosome 18q21.31 was identified and contained several OMIM genes, including the @entity4 gene, and (2) an 0.87-Mb duplication at chromosome region 16p13.3 was found and contained one gene. Parental samples revealed that the @entity0 's father had the same deletion and duplication. This case appears to be the first with a deletion of 18q21.31 encompassing the @entity4 gene presenting with features of @entity6 and @entity1 . CONCLUSIONS: Haploinsufficiency of the @entity4 gene either through whole gene deletion or nonsense or missense mutations is associated with a significant risk of @entity1 . The case emphasizes both the role of the @entity4 gene in @entity1 as well as the importance of looking for chromosomal microdeletions/duplications as a cause of @entity1 in @entity0 with @entity2 or @entity3 .

title: Deletion of the @entity4 Gene in a 9-Year-Old Obese XXXX .

answer: @entity0


abstract: UNASSIGNED: The genome of the @entity2 apicoplast, which has a higher copy number compared with current targets for molecular diagnosis of @entity0 , appears to be a suitable target for detection of submicroscopic infections that are capable of sustaining transmission. Novel primers targeting a conserved segment of the apicoplast (PFC10_AP 0010:rRNA) were designed and used in a number of different high throughput platforms such as single-step PCR (ssPCR), nested PCR (nPCR) and loop-mediated isothermal amplification (LAMP) for parasite detection. Replicates of ten-fold serial dilutions of @entity2 DNA, with equivalent parasite density ranges of 200 000 to 0.2 parasites/ L, were used to determine the limit of detection and repeatability of each assay. A panel of 184 archived DNA samples extracted from either @entity1 whole blood or dried blood spots, from across West Africa and South East Asia was used to determine the diagnostic performance of the assays. All assays amplified the 2 parasites/ L dilution except the ssPCR, which amplified two of the three replicates. Using an 18S rRNA PCR as reference, the sensitivity was 98% (95% CI 93-100%) for the LAMP assay, 87% (95% CI 79-93%) for ssPCR and 100% (95% CI 97-100%) for nPCR. Specificity was 91% (95% CI 83-96%) for LAMP, 82% (95% CI 72-90%) for ssPCR and 66% (95% CI 54-76%) for nPCR. The apicoplast genome-based nPCR detected more positive samples overall than the reference method. Discrepant samples were confirmed as true positives using a probe-based real-time quantitative PCR assay. The results show that the apicoplast genome is a suitable target for molecular diagnosis of @entity0 .

title: Validation of an apicoplast genome target for the detection of XXXX species using polymerase chain reaction and loop mediated isothermal amplification.

answer: @entity2


abstract: OBJECTIVE: To examine geographic and facility variation in cognitive and motor functional outcomes after postacute inpatient rehabilitation in @entity0 with @entity1 . DESIGN: Retrospective cohort design using Centers for Medicare and Medicaid Services ( @entity2 ) claims files. Records from 1209 rehabilitation facilities in 298 hospital referral regions (HRRs) were examined. @entity0 records were analyzed using linear mixed models. Multilevel models were used to calculate the variation in outcomes attributable to facilities and geographic regions. SETTING: Inpatient rehabilitation units and facilities. @entity0 : @entity0 (N=145,460) with @entity1 discharged from inpatient rehabilitation from 2006 through 2009. INTERVENTION: Not applicable. MAIN OUTCOME MEASURES: Cognitive and motor functional status at discharge measured by items in the @entity2 Inpatient Rehabilitation Facility- @entity0 Assessment Instrument. RESULTS: Variation profiles indicated that 19.1% of rehabilitation facilities were significantly below the mean functional status rating (mean    SD, 81.58  22.30), with 221 facilities (18.3%) above the mean. Total discharge functional status ratings varied by 3.57 points across regions. Across facilities, functional status values varied by 29.2 points, with a 9.1-point difference between the top and bottom deciles. Variation in discharge motor function attributable to HRR was reduced by 82% after controlling for cluster effects at the facility level. CONCLUSIONS: Our findings suggest that variation in motor and cognitive function at discharge after postacute rehabilitation in @entity0 with @entity1 is accounted for more by facility than geographic location.

title: Geographic and Facility Variation in Inpatient XXXX Rehabilitation: Multilevel Analysis of Functional Status.

answer: @entity1


abstract: BACKGROUND: We aimed to determine the incidence, predictors, clinical characteristics, management, and outcomes of @entity5 ( @entity5 ) after transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: This multicenter registry included 53 @entity0 (mean age, 79  8 years; @entity0 , 57%) who suffered @entity5 after TAVI of 7944 @entity0 after a mean follow-up of 1.1  1.2 years (incidence, 0.67%, 0.50% within the first year after TAVI). Mean time from TAVI was 6 months (interquartile range, 1-14 months). Orotracheal intubation (hazard ratio, 3.87; 95% confidence interval, 1.55-9.64; P=0.004) and the self-expandable CoreValve system (hazard ratio, 3.12; 95% confidence interval, 1.37-7.14; P=0.007) were associated with @entity5 (multivariate analysis including 3067 @entity0 with individual data). The most frequent causal microorganisms were coagulase-negative staphylococci (24%), followed by @entity4 (21%) and enterococci (21%). @entity1 were present in 77% of @entity0 (transcatheter valve leaflets, 39%; stent frame, 17%; mitral valve, 21%). At least 1 complication of @entity5 occurred in 87% of @entity0 ( @entity3 in 68%). However, only 11% of @entity0 underwent valve intervention (valve explantation and valve-in-valve procedure in 4 and 2 @entity0 , respectively). The mortality rate in hospital was 47.2% and increased to 66% at the 1-year follow-up. @entity5 complications such as @entity3 (P=0.037) and @entity2 (P=0.002) were associated with increased in-hospital mortality. CONCLUSIONS: The incidence of @entity5 at 1 year after TAVI was 0.50%, and the risk increased with the use of orotracheal intubation and a self-expandable valve system. Staphylococci and enterococci were the most common agents. Although most @entity0 presented at least 1 complication of @entity5 , valve intervention was performed in a minority of @entity0 , and nearly half of the @entity0 died during the hospitalization period.

title: XXXX after transcatheter aortic valve implantation: results from a large multicenter registry.

answer: @entity5


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a @entity5 most often caused by mutations in different genes. It is characterized by hypocalcaemia with inappropriately low @entity6 levels. Knowledge about this group of @entity0 , including their mortality and morbidity, is very sparse. The aim was to identify all @entity0 diagnosed with nonsurgical @entity4 in Denmark and assess their mortality and risk of complications. Through registers and review of individual @entity0 hospital charts we identified all @entity0 diagnosed with nonsurgical @entity4 in Denmark between 1977 and 2012. We assessed their mortality and morbidity by comparing them with a group of age- and gender-matched population-based controls. We identified a total of 180 @entity0 with nonsurgical @entity4 among whom 123 (68%) were alive at the date of follow-up (prevalence of 2.3/100,000 inhabitants). Compared with controls, mortality was not increased, but @entity0 had a significantly increased risk of @entity2 (hazard ratio [HR] 6.01), cardiovascular diseases (HR 1.91), neuropsychiatric complications (HR 2.45), infections (HR 1.94), seizures (HR 10.05), @entity3 (HR 4.21), and @entity1 at the upper extremities (HR 1.93). In contrast @entity0 had significantly reduced risk of malignant diseases (HR 0.44). In conclusion, nonsurgical @entity4 is a rare disease associated with a number of complications that should be considered when taking care of these @entity0 .    2015 American Society for Bone and Mineral Research.

title: The Epidemiology of Nonsurgical XXXX in Denmark: A Nationwide Case Finding Study.

answer: @entity4


abstract: Influence of the Dietary level of @entity2 on the @entity3 utritional Status of the Lactating @entity0 and the litter. Seven Groups of female @entity0 which had given birth to the litters of 8 youngs (or litters adjusted to 8 youngs) were fed diets containing respectively 0.5, 1, 2, 4, 8, 16 or 32 mg/kg of @entity2 . Eighteen days after littering, the @entity2 content was measured in female tissues (blood, liver, carcass) or in those of the youngs (liver, carcass). Besides, the @entity2 content in the stomach of the youngs was measured, 3, 7 and 14 days after birth. 1. In the females there are linear or cubic relationships between the @entity2 content in the tissues and the log-concentration of the vitamin in the diet. In the liver and the carcass, it seems that the vitamin level in the tissues reaches a plateau when the dietary level is below 1 mg/kg or above 16 mg/kg. 2. On day 7th or 14th the gastric vitamin content (milk) in the youngs gradually increases, as the dietary @entity1 supply does, and especially on day 14th when the dietary level of @entity2 is 2 mg/kg or higher. 3. In the youngs, the organ @entity2 contents markedly increase when the dietary supply rises from 1 to 8 mg/kg. Below 1 mg/kg and beyond 8 mg/kg there is a plateau. 4. These results suggest that the @entity2 fixation in the offspring tissues occurs prior to the fixation in the lactating mother. The priority would be proved by the fast increase of the milk content in @entity2 during the 2nd week when the vitamin dietary supply rises.

title: [Vitamin B1 nutritional status of the lactating XXXX and her litter as a function of the dietary level of thiamine].

answer: @entity0


abstract: BACKGROUND: Present limitations in primary and secondary prevention of @entity1 mean that many @entity0 with @entity1 present with advanced retinal complications, often requiring surgery (vitrectomy). OBJECTIVES: To determine the outcomes of vitrectomy for advanced @entity1 and to examine context-specific risk factors that may influence outcomes and decisions affecting resource allocation. METHODS: This was a retrospective cohort study of 124 vitrectomies with up to 6 months' follow-up. RESULTS: Visual acuity was 6/60 or worse in the better eye in 23.4% of @entity0 at presentation. The mean visual acuity of the listed eye was 2/60. The fellow eye was considered inoperable in 20.2% of cases. Visual function declined significantly in 26.2% of @entity0 while awaiting surgery. The average waiting time until surgery was 2.9 months (range 1 day - 9 months). Epiretinal membranes were present in 93.6% of cases, and posterior iatrogenic breaks occurred in 49.2%. Silicone oil was used in 24.2%. Visual acuity improved in 54.9%, was unchanged in 30.1%, and worsened in 14.0% of cases at 6 months. @entity0 with poorer vision at surgery were more likely to improve (odds ratio 2.15; p=0.048). Factors associated with a worse visual outcome were increased age at surgery (p=0.042) and posterior iatrogenic @entity3 (p=0.007). @entity2 was not associated with worse visual outcomes. CONCLUSION: Vitrectomy improved or stabilised vision in 85.0% of cases, although outcomes were unpredictable. A long waiting time to surgery contributed to @entity0 morbidity. The presence of @entity2 did not predict poorer visual outcomes.

title: Outcomes of vitrectomy for advanced XXXX at Groote Schuur Hospital, Cape Town, South Africa.

answer: @entity1


abstract: STUDY DESIGN: Prospective, randomized trial. PURPOSE: The treatment of @entity2 ( @entity2 ) with two-level fusion has been associated with a reasonable rate of complications. The aim of the present study was to compare (Hybrid) stand-alone @entity3 ( @entity3 ) at L5/S1 with total disc replacement at L4/5 (TDR) as an alternative surgical strategy to (Fusion) 2-level circumferential fusion employing @entity5 ( @entity5 ) with transpedicular stabilization at L4-S1. METHODS: A total of 62 @entity0 with symptomatic @entity2 of segments L5/S1 (Modic >= 2  ) and L4/5 (Modic  <=2  ; positive discography) were enrolled; 31 were treated with Hybrid and 31 with Fusion. Preoperatively, at 0, 12, and a mean follow-up of 37  months, clinical (ODI, VAS) and radiological evaluations (plain/extension-flexion radiographs evaluated for implant failure, fusion, global and segmental @entity4 , and ROM) were performed. RESULTS: In 26 of 31 Hybrid and 24 of 31 Fusion @entity0 available at the final follow-up, we found a significant clinical improvement compared to preoperatively. Hybrid @entity0 had significantly lower VAS scores immediately postoperatively and at follow-up compared to Fusion @entity0 . The complication rates were low and similar between the groups. Lumbar @entity4 increased in both groups. The increase was mainly located at L4-S1 in the Hybrid group and at L1-L4 in the Fusion group. Hybrid @entity0 presented with increased ROM at L4/5 and L3/4, and Fusion @entity0 presented with increased ROM at L3/4, with significantly greater ROM at L3/4 compared to Hybrid @entity0 at follow-up. CONCLUSIONS: Hybrid surgery is a viable surgical alternative for the presented indication. Approach-related inferior @entity1 and the balanced @entity4 resulted in superior clinical outcomes compared to two-level circumferential fusion with @entity5 .

title: @entity3 and total disc replacement versus 2-level circumferential fusion with XXXX : a prospective, randomized, clinical and radiological trial.

answer: @entity5


abstract: STUDY DESIGN: Prospective, randomized trial. PURPOSE: The treatment of @entity2 ( @entity2 ) with two-level fusion has been associated with a reasonable rate of complications. The aim of the present study was to compare (Hybrid) stand-alone @entity3 ( @entity3 ) at L5/S1 with total disc replacement at L4/5 (TDR) as an alternative surgical strategy to (Fusion) 2-level circumferential fusion employing @entity5 ( @entity5 ) with transpedicular stabilization at L4-S1. METHODS: A total of 62 @entity0 with symptomatic @entity2 of segments L5/S1 (Modic >= 2  ) and L4/5 (Modic  <=2  ; positive discography) were enrolled; 31 were treated with Hybrid and 31 with Fusion. Preoperatively, at 0, 12, and a mean follow-up of 37  months, clinical (ODI, VAS) and radiological evaluations (plain/extension-flexion radiographs evaluated for implant failure, fusion, global and segmental @entity4 , and ROM) were performed. RESULTS: In 26 of 31 Hybrid and 24 of 31 Fusion @entity0 available at the final follow-up, we found a significant clinical improvement compared to preoperatively. Hybrid @entity0 had significantly lower VAS scores immediately postoperatively and at follow-up compared to Fusion @entity0 . The complication rates were low and similar between the groups. Lumbar @entity4 increased in both groups. The increase was mainly located at L4-S1 in the Hybrid group and at L1-L4 in the Fusion group. Hybrid @entity0 presented with increased ROM at L4/5 and L3/4, and Fusion @entity0 presented with increased ROM at L3/4, with significantly greater ROM at L3/4 compared to Hybrid @entity0 at follow-up. CONCLUSIONS: Hybrid surgery is a viable surgical alternative for the presented indication. Approach-related inferior @entity1 and the balanced @entity4 resulted in superior clinical outcomes compared to two-level circumferential fusion with @entity5 .

title: XXXX and total disc replacement versus 2-level circumferential fusion with @entity5 : a prospective, randomized, clinical and radiological trial.

answer: @entity3


abstract: Sixteen socially phobic outpatients underwent a 4-week course of social skills training that attempted to maximize rehearsal in real-life settings. The therapy was largely conducted by nonprofessional volunteers after a 2-hour training workshop. It consisted of multiple role-played practice in the clinic, followed immediately by rehearsal in a real-life setting in the company of a nonprofessional therapist and a fellow @entity0 . Subsequently, @entity0 were randomly paired to perform further rehearsals between sessions. Drug therapy was controlled by double blind assignment to @entity3 or inert placebo throughout the course of treatment. Measures of specific fears, generalized social @entity1 , self-image, and global tension and @entity1 were administered 1 month before treatment, immediately before and after treatment, and at 6 months follow-up. During a 4-week drug-free period prior to active treatment no improvement was noted on any measures. After the 4-week treatment period significant improvement had occurred on all outcome measures. @entity3 and placebo subgroups showed very similar results. Treatment gains were sustained at follow-up. It was concluded that repeated behavior rehearsal, both in the clinic and in real life is a cost-effective treatment procedure for many @entity2 . The approach is straightforward and can be applied by nonprofessionals, including the @entity0 themselves, after limited training and with minimal supervision.

title: The treatment of XXXX . Real-life rehearsal with nonprofessional therapists.

answer: @entity2


abstract: OBJECTIVE: Current @entity1 ( @entity1 ) screening recommendations in preterm @entity0 often include a repeat @entity1 , regardless of initial findings. The objective of this study is to determine the rate of subsequent severe @entity3 ( @entity3 ), @entity5 ( @entity5 ), or @entity6 ( @entity6 ) among @entity0   <   30 weeks gestation (EGA) with a normal @entity1 at day of life (DOL) 4-10. METHODS: Retrospectively collected data were analyzed for all @entity0   <   30 weeks EGA cared for in one NICU from 1 January 2010 to 31 August 2014. @entity0 with severe @entity2 were excluded. We reviewed the first three @entity7 and last documented @entity1 . Severe @entity3 was defined as   >   Papile grade 2 and significant interval @entity1 change was defined as development of severe @entity3 , @entity6 , or @entity5 . RESULTS: Of the 383 @entity0 who had an initial screening @entity1 between DOL 4 and 10, 258 (67%) were initially normal and repeat screening was performed in 228 of these. None developed severe @entity3 on follow-up @entity1 . One @entity0 developed @entity5 secondary to @entity4 , and one developed echogenicity concerning for @entity6 that later resolved. CONCLUSIONS: Among very preterm @entity0 with a normal @entity1 between DOL 4 and 10, routine follow-up @entity1 is unlikely to identify a significant change.

title: Do normal head ultrasounds need repeating in XXXX less than 30 weeks gestation?

answer: @entity0


abstract: In a consecutive series of 219 @entity0 with a @entity6 of the anterior part of the circle of Willis, 119 @entity0 (54%) made a good recovery and 67 (31%) died. Of 53 @entity0 who did not have surgery, six (11%) made a good recovery and 37 (70%) died. Urgent surgery with evacuation of an associated significant @entity7 was performed in 30 @entity0 ; nine (30%) made a good recovery and 15 (50%) died. Delayed surgery was performed in 55 @entity0 of whom 42 (76%) made a good recovery and two (4%) died. Early intracranial operation (within 48 to 60 hours after @entity3 ( @entity3 )) was performed in 81 @entity0 who were in Grades I to III prior to surgery. Sixty @entity0 (74%) made a good recovery, and eight died within a month. Five @entity0 were severely disabled and died 2 to 8 months after @entity3 and surgery. In 17 @entity0 , although the immediate postoperative course was uneventful, evidence of @entity9 developed 4 to 13 days after the bleed and resulted in @entity2 in eight @entity0 . A poor outcome was correlated with a history of elevated blood pressure before @entity3 . Seven @entity0 , of whom six were @entity0 of @entity0 -bearing age, demonstrated pronounced @entity8 on postoperative angiography; nevertheless, they remained well and free from @entity1 symptoms after surgery. Early operation combined with removal of @entity3 and rinsing the basal cisterns does not eliminate the risk of delayed @entity9 . Such early surgery, however, improves overall outcome by preventing recurrent @entity4 , and may also reduce the frequency of @entity5 .

title: Results of early operations for XXXX .

answer: @entity6


abstract: BACKGROUND: The purpose of the study was to define the most appropriate management of the @entity2 ( @entity2 ) in young adults. METHODS: A retrospective study was performed on @entity0 with @entity2 <30 years old. The data collected included initial treatment, @entity1 margins, reconstruction, and follow-up. @entity0 evaluated speech, chewing, swallowing, and facial appearance after definitive treatment. RESULTS: Thirteen @entity0 were identified with recurrent solid/multicystic disease requiring further treatment. Definitive treatment involved segmental mandibulectomy and reconstruction with free fibular flap in all @entity0 . Seven @entity0 had immediate reconstruction (group A) and 6 had secondary (group B). Mandibular resection was planned at least 2 cm beyond the radiological limit, free margins were achieved in all @entity0 , and all flaps were transplanted successfully. In group A, functional score was 13.7    0.45 and facial appearance score was 4.5    0.49, whereas in group B were 11.16    0.37 and 3.3    0.5, respectively (both p < .05). CONCLUSION: Aggressive resection of the @entity2 and immediate reconstruction is strongly advised.    2015 Wiley Periodicals, Inc. Head Neck 38: E1947-E1954, 2016.

title: Recurrent XXXX in young adults.

answer: @entity2


abstract: OBJECTIVE: Recent reviews on the sentinel lymph node (SLN) procedure in cervical @entity1 have shown that bilateral SLN detection and ultra staging are safe and superior options compared to a unilateral detection, frozen section and H_E analysis. So far, nobody identified a subgroup of @entity0 in whom a SLN procedure may replace pelvic lymph node dissection (PLND). METHODS: We searched PubMed, Embase, CINAHL and Cochrane from inception up to November 26, 2014. Studies reporting SLN detection, and/or histological outcome of the SLN were included. Methodological quality was assessed with the Quality Assessment of Diagnostic Accuracy Studies tool by two independent reviewers. Data to complete 2*2 contingency tables were obtained, and @entity0 -, study- and technique characteristics were extracted. Results were pooled and plotted in forest plots. RESULTS: Forty-seven studies (4130 @entity0 ) were analyzed. Pooled data of diagnostic accuracy on ultra staging (18 studies; 1275 @entity0 ) showed a sensitivity of 94% (95% CI 80-99%) and negative predictive values ranging between 91 and 100%. After ultra staging, 19 false negative results remained. Prerequisites such as early FIGO stage ( @entity3 , @entity2 , IIA @entity1 size <40mm), no suspicious pre-, and per-operative lymph nodes, and bilateral negative SLNs after ultra staging resulted in 1 remaining false negative result among 1257 @entity0 (0.08%). Pooled data on a combined tracer in early @entity1 @entity0 with @entity1 size <20mm (6 studies; 276 @entity0 ) resulted in 87% bilateral SLN detection. CONCLUSIONS: Early @entity1 @entity0 (FIGO @entity3 , @entity2 , IIA @entity1 size <40mm) who have no suspicious pre-, and per-operative lymph nodes, and have bilateral negative SLNs after ultra staging, have a residual risk of 0.08% (1/1257) on occult metastases. On the basis of these results we recommend not to perform a full PLND in these @entity0 .

title: The sentinel node procedure in early XXXX , taking the next step; a diagnostic review.

answer: @entity1


abstract: Currently there is no predictor for survival after adjuvant @entity6 in @entity0 with @entity2 ( @entity2 ) who have undergone curative resection. Thirty-eight @entity0 who underwent curative resection of @entity2 received adjuvant @entity6 therapy between August 2009 and March 2012. Clinicopathological parameters including @entity0 factors, @entity1 factors, liver background, and inflammatory factors (before surgery and dynamic changes after @entity6 therapy) were evaluated to identify predictors for @entity5 ( @entity5 ) and @entity5 ( @entity5 ). The recurrence rate, mortality rate, and clinicopathological data were also compared. Increased NLR after @entity6 (HR  =  3.199, 95  % CI 1.365-7.545, P  =  0.008), increased GGT after @entity6 (HR  =  3.204, 95  % CI 1.333-7.700, P  =  0.009), and the presence of @entity4 (HR  =  2.381, 95  % CI 1.064-5.328, P  =  0.035) were risk factors related to @entity5 . By contrast, increased NLR after @entity6 was the only independent risk factor related to @entity5 (HR  =  4.647, 95  % CI 1.266-17.053, P  =  0.021). @entity0 with increased NLR or increased GGT after @entity6 had a higher incidence of recurrence and @entity3 . @entity0 who had increased NLR tended to have higher preoperative levels of NLR and GGT. There were no differences in clinicopathological factors in @entity0 with increased GGT and decreased GGT. In conclusion, increased NLR predicted a worse @entity5 and @entity5 in @entity0 with @entity2 who underwent curative resection with adjuvant @entity6 therapy. Increased GGT predicted a worse @entity5 . NLR and GGT can be monitored dynamically before and after @entity6 therapy.

title: Adjuvant @entity6 therapy in XXXX with resected @entity2 : evaluation of predictive factors.

answer: @entity0


abstract: Currently there is no predictor for survival after adjuvant @entity6 in @entity0 with @entity2 ( @entity2 ) who have undergone curative resection. Thirty-eight @entity0 who underwent curative resection of @entity2 received adjuvant @entity6 therapy between August 2009 and March 2012. Clinicopathological parameters including @entity0 factors, @entity1 factors, liver background, and inflammatory factors (before surgery and dynamic changes after @entity6 therapy) were evaluated to identify predictors for @entity5 ( @entity5 ) and @entity5 ( @entity5 ). The recurrence rate, mortality rate, and clinicopathological data were also compared. Increased NLR after @entity6 (HR  =  3.199, 95  % CI 1.365-7.545, P  =  0.008), increased GGT after @entity6 (HR  =  3.204, 95  % CI 1.333-7.700, P  =  0.009), and the presence of @entity4 (HR  =  2.381, 95  % CI 1.064-5.328, P  =  0.035) were risk factors related to @entity5 . By contrast, increased NLR after @entity6 was the only independent risk factor related to @entity5 (HR  =  4.647, 95  % CI 1.266-17.053, P  =  0.021). @entity0 with increased NLR or increased GGT after @entity6 had a higher incidence of recurrence and @entity3 . @entity0 who had increased NLR tended to have higher preoperative levels of NLR and GGT. There were no differences in clinicopathological factors in @entity0 with increased GGT and decreased GGT. In conclusion, increased NLR predicted a worse @entity5 and @entity5 in @entity0 with @entity2 who underwent curative resection with adjuvant @entity6 therapy. Increased GGT predicted a worse @entity5 . NLR and GGT can be monitored dynamically before and after @entity6 therapy.

title: Adjuvant XXXX therapy in @entity0 with resected @entity2 : evaluation of predictive factors.

answer: @entity6


abstract: Currently there is no predictor for survival after adjuvant @entity6 in @entity0 with @entity2 ( @entity2 ) who have undergone curative resection. Thirty-eight @entity0 who underwent curative resection of @entity2 received adjuvant @entity6 therapy between August 2009 and March 2012. Clinicopathological parameters including @entity0 factors, @entity1 factors, liver background, and inflammatory factors (before surgery and dynamic changes after @entity6 therapy) were evaluated to identify predictors for @entity5 ( @entity5 ) and @entity5 ( @entity5 ). The recurrence rate, mortality rate, and clinicopathological data were also compared. Increased NLR after @entity6 (HR  =  3.199, 95  % CI 1.365-7.545, P  =  0.008), increased GGT after @entity6 (HR  =  3.204, 95  % CI 1.333-7.700, P  =  0.009), and the presence of @entity4 (HR  =  2.381, 95  % CI 1.064-5.328, P  =  0.035) were risk factors related to @entity5 . By contrast, increased NLR after @entity6 was the only independent risk factor related to @entity5 (HR  =  4.647, 95  % CI 1.266-17.053, P  =  0.021). @entity0 with increased NLR or increased GGT after @entity6 had a higher incidence of recurrence and @entity3 . @entity0 who had increased NLR tended to have higher preoperative levels of NLR and GGT. There were no differences in clinicopathological factors in @entity0 with increased GGT and decreased GGT. In conclusion, increased NLR predicted a worse @entity5 and @entity5 in @entity0 with @entity2 who underwent curative resection with adjuvant @entity6 therapy. Increased GGT predicted a worse @entity5 . NLR and GGT can be monitored dynamically before and after @entity6 therapy.

title: Adjuvant @entity6 therapy in @entity0 with resected XXXX : evaluation of predictive factors.

answer: @entity2


abstract: Induction chemotherapy has many benefits of in locally advanced @entity1 (LARC); one of these is the better control of distant failure. Hyperfractionated radiotherapy (HFRT) is new approach still on evaluation in preoperative setting of @entity1 . We aimed to evaluate the efficacy of induction FOLFOX followed by HFRT in LARC. From September 2011 to December 2013, 27 @entity0 with LARC were enrolled in this prospective, phase I-II study. Induction FOLFOX bolus was given for two cycles followed by HFRT (1.5  Gy twice day for 30 fractions over 3  weeks for a total of 45  Gy). @entity3 ( @entity3 ) bolus was administrated during first and last 3  days of radiotherapy. Surgical resection was performed in 4-5  weeks further and followed by adjuvant FOLFOX bolus regimen. Twenty-one (77.8  %) @entity0 were males and 22. 2  % of @entity0 were females, and the median age at diagnosis was 46  years. Low sited @entity1 was the most presenting site (55.6  %). Clinically positive lymph nodes were presented in 70.4  % of @entity0 . Twenty @entity0 (74.1  %) underwent sphincter sparing procedure. Pathological complete response (pCR) was achieved in seven @entity0 (25.9  %). Tumor and nodal downstaging were recorded in (70.3  %) and (42.1  %) of @entity0 , respectively. Acute and late @entity2 were in acceptable range. Two-year disease-free survival was 70.2  %, and overall survival was 87.5  %. Induction FOLFOX followed by HFRT and concurrent @entity3 improves pCR in LARC, and this combination was feasible with acceptable @entity2 . Further evaluations are mandatory for this new approach.

title: Induction FOLFOX followed by preoperative hyperfractionated radiotherapy plus bolus XXXX in locally advanced rectal carcinoma: single arm phase I-II study.

answer: @entity3


abstract: CONTEXT: Episodic @entity3 is a relevant aspect in @entity0 with @entity1 . OBJECTIVES: The aim of this study was to assess the different aspects of this clinical phenomenon. METHODS: A consecutive sample of @entity0 with @entity1 admitted to different settings for a period of six months was surveyed. The presence of background @entity3 and episodic @entity3 , their intensity (numerical scale 0-10), and drugs used for treatment were collected. Factors inducing episodic @entity3 and its influence on daily activities were investigated. RESULTS: Of 921 @entity0 , 29.3% (n  =  269) had @entity3 and 134 @entity0 (49.8%) were receiving drugs for background @entity3 . In the multivariate analysis, the risk of @entity3 increased with @entity2 , although it decreased in @entity0 receiving disease-oriented therapy and @entity0 with @entity4 . The prevalence of episodic @entity3 was 70.9% (n  =  188), and its mean intensity was 7.1 (SD 1.6). The mean  duration of untreated episodic @entity3 was 19.9  minutes (SD 35.3); 41% of these @entity0 were receiving drugs  for episodic @entity3 . The majority of episodic @entity3 events (88.2%) were triggered by activity. In the multivariate analysis, higher Karnofsky Performance Status levels were significantly related to episodic @entity3 , although @entity0 receiving disease-oriented therapy were less likely to have episodic @entity3 . CONCLUSION: This study showed that episodic @entity3 frequently occurs in @entity0 with @entity3 in the advanced stage of disease, has a severe intensity, and is characterized by rapid onset and short duration, which require rapid measures.

title: Epidemiology and Characteristics of Episodic Breathlessness in XXXX @entity0 : An Observational Study.

answer: @entity1


abstract: CONTEXT: Episodic @entity3 is a relevant aspect in @entity0 with @entity1 . OBJECTIVES: The aim of this study was to assess the different aspects of this clinical phenomenon. METHODS: A consecutive sample of @entity0 with @entity1 admitted to different settings for a period of six months was surveyed. The presence of background @entity3 and episodic @entity3 , their intensity (numerical scale 0-10), and drugs used for treatment were collected. Factors inducing episodic @entity3 and its influence on daily activities were investigated. RESULTS: Of 921 @entity0 , 29.3% (n  =  269) had @entity3 and 134 @entity0 (49.8%) were receiving drugs for background @entity3 . In the multivariate analysis, the risk of @entity3 increased with @entity2 , although it decreased in @entity0 receiving disease-oriented therapy and @entity0 with @entity4 . The prevalence of episodic @entity3 was 70.9% (n  =  188), and its mean intensity was 7.1 (SD 1.6). The mean  duration of untreated episodic @entity3 was 19.9  minutes (SD 35.3); 41% of these @entity0 were receiving drugs  for episodic @entity3 . The majority of episodic @entity3 events (88.2%) were triggered by activity. In the multivariate analysis, higher Karnofsky Performance Status levels were significantly related to episodic @entity3 , although @entity0 receiving disease-oriented therapy were less likely to have episodic @entity3 . CONCLUSION: This study showed that episodic @entity3 frequently occurs in @entity0 with @entity3 in the advanced stage of disease, has a severe intensity, and is characterized by rapid onset and short duration, which require rapid measures.

title: Epidemiology and Characteristics of Episodic Breathlessness in @entity1 XXXX : An Observational Study.

answer: @entity0


abstract: UNASSIGNED: The primary aim of the study was to evaluate the incidence of de novo major involvement during follow-up in a cohort of @entity0 with @entity2 ( @entity2 ); the secondary aim was to analyse the epidemiological profile and the long-term outcome of those @entity0 who developed new major involvement. Among our cohort of 120 @entity2 @entity0 , we evaluated all subjects who had no major organ involvement during the early years of their disease; specifically, at disease onset, the 52  % of the cohort presented a prevalent mucocutaneous involvement. The primary outcomes were represented by the following: Hatemi et al. (Rheum Dis Clin North Am 39(2):245-61, 2013) the incidence of de novo major involvement during the follow-up and Hatemi et al. (Clin Exp Rheumatol 32(4 Suppl 84):S112-22, 2014) the use of immunosuppressive drugs during the follow-up. We have defined the development of de novo major involvement during the follow-up as the occurrence of severe ocular, vascular or CNS involvement after a latency period from the diagnosis of at least 3  years. Among 62 @entity0 characterized by a mild onset of disease, we observed that after at least 3  years from the diagnosis, 21 @entity2 @entity0 (34  %) still developed serious morbidities. Specifically, three @entity0 developed ocular involvement, nine @entity0 developed @entity1 and nine @entity0 presented vascular involvement. Comparing main epidemiological and clinical findings of the two groups, we observed that @entity0 who developed de novo major involvement were more frequently males and younger; furthermore, 95  % of these @entity0 were characterized by a young onset of disease (p   <   0.001). Being free of major organ complication in the first years of @entity2 is not necessary a sign of a favourable outcome. Globally, the development of de novo major involvement during the coursfce of @entity2 suggests that a tight control is strongly recommended during the course of the disease.

title: Development of de novo major involvement during follow-up in XXXX .

answer: @entity2


abstract: 1. The ionic currents in slow fibres isolated from @entity0 soleus muscle have been studied under voltage-clamp conditions with a double @entity1 -gap method and the results are compared to those obtained from fast fibres isolated from the iliacus muscle. 2. The mean value of the resting potential in slow fibres is -70 mV. a value 8 mV more positive that the mean resting potential of fast fibres (-78 mV). 3. In slow muscle, a fast inward current which is blocked by @entity2 and which depends on external @entity3 concentration is presumed to be carried by @entity3 ions. The characteristics of this current, which are time- and voltage-dependent, are similar to those of the iliacus fibres. From a holding potential at -86 mV, this inward current is maximal (2.6 mA/cm2 +/- 0.3) at +49.1 mV +/- 1.5 (mean +/- S.E. of mean), reverses at +127.3 mV +/- 2.2 (mean +/- S.E. of mean), and its half inactivation occurs at +23.2 mV +/- 0.8 (mean +/- S.E. of mean). 4. The delayed outward current in slow fibres is unchanged by exposure to @entity5 free solution and has a time course very different from that found in fast fibres. This current reaches an initial peak in 5-10 msec and a second peak or steady level after 40-150 msec. The decay of the outward current is also very different, being ten times slower than that in fast fibres (1500-3000 msec). 5. Analysis of the tail currents reveals the existence of two components of delayed current in slow fibres. The faster component reverses at a potential of 11.3 mV +/- 0.9 (mean +/- S.E. of mean) positive to the holding potential (equivalent to a membrane potential of about -75 mV), in contrast to a reversal potential of 35.4 mV +/- 2.5 (mean +/- S.E. of mean) positive to the holding potential for the slower component (equivalent to a membrane potential of about -51 mV. 6. In L- @entity4 solution the characteristics of the inward-going rectification are the same in the two types of muscle.

title: Ionic currents in slow twitch skeletal muscle in the XXXX .

answer: @entity0


abstract: 1. The role of the @entity3 in the regulation of intragastric pressure was investigated by quantifying the effect of nerve section on the response to a standard fluid inflation of the stomach. An opportunity was also taken to compare the responses to a step and physiological ramp inflation of the same volume (50 ml). 2. The peak pressure at the end ot the step inflation (13.6 +/- 1.0 cm @entity1 ) was twice that for a ramp inflation (6.2 +/- 0.4 cm @entity1 ). 5 min after the peak the pressures were similar (4.8 +/- 0.3 cm @entity1 ; 4.7 +/- 0.3 cm @entity1 ) for both. 3. Vagotomy produced a significant increase in the intragastric pressure response for both the peak and plateau levels of the step and ramp inflations. 4. @entity2 produced a statistically significant decrease in the pressure response to both step and ramp inflation. 5. Splanchnic nerve section produced an increase in the intragastric pressure response to both step and ramp inflations although the values failed to reach the 5% significance level. However, following vagotomy or @entity2 , section of the splanchnic nerves produced a statistically significant increase in the pressure response to inflation. 6. These results indicate that the vagal cholinergic excitatory and vagal non-cholinergic, non-adrenergic inhibitory fibres are activated at physiological levels of @entity0 and play a role in the regulation of intragastric pressure. The splanchnic nerves also play a role although in the intact animal they are suppressed by the action of the vagus nerve.

title: The role of the XXXX in the regulation of intragastric pressure in the ferret.

answer: @entity3


abstract: @entity1 ( @entity1 ) is a @entity3 characterized by abnormal expansion of mast cells (MCs) in visceral organs. The skin is involved in most cases. In adult @entity0 the transforming KIT mutation @entity5 is usually present and confers resistance against @entity4 . Therefore, @entity4 is not recommended for @entity0 with KIT @entity5 + @entity1 . Nonetheless, @entity4 may work in @entity0 with @entity1 lacking KIT @entity5 . However, little is known about long-term efficacy and safety of this drug in @entity1 . We report on a 62-year-old female @entity0 with indolent @entity1 (ISM) who suffered from severe debilitating skin involvement despite therapy with anti-mediator-type drugs, @entity6 and ultraviolet-A-radiation. Although multifocal MC infiltrates were detected in the bone marrow by immunohistochemistry, no KIT mutation was found by sequencing analysis. In 2003, treatment with @entity4 (induction, 400 mg/day; maintenance, 200 mg/day) was initiated. During therapy, @entity2 and tryptase levels decreased. Treatment was well tolerated without any side effects. After 10 years, @entity2 have disappeared and the tryptase level is within normal range. This case-study confirms the long-term efficacy and safety of @entity4 in @entity0 with @entity1 lacking activating KIT mutations. @entity4 should be considered in select cases of @entity1 in whom MCs exhibit wild-type KIT.

title: Long-lasting complete response to XXXX in a @entity0 with systemic mastocytosis exhibiting wild type KIT.

answer: @entity4


abstract: @entity1 ( @entity1 ) is a @entity3 characterized by abnormal expansion of mast cells (MCs) in visceral organs. The skin is involved in most cases. In adult @entity0 the transforming KIT mutation @entity5 is usually present and confers resistance against @entity4 . Therefore, @entity4 is not recommended for @entity0 with KIT @entity5 + @entity1 . Nonetheless, @entity4 may work in @entity0 with @entity1 lacking KIT @entity5 . However, little is known about long-term efficacy and safety of this drug in @entity1 . We report on a 62-year-old female @entity0 with indolent @entity1 (ISM) who suffered from severe debilitating skin involvement despite therapy with anti-mediator-type drugs, @entity6 and ultraviolet-A-radiation. Although multifocal MC infiltrates were detected in the bone marrow by immunohistochemistry, no KIT mutation was found by sequencing analysis. In 2003, treatment with @entity4 (induction, 400 mg/day; maintenance, 200 mg/day) was initiated. During therapy, @entity2 and tryptase levels decreased. Treatment was well tolerated without any side effects. After 10 years, @entity2 have disappeared and the tryptase level is within normal range. This case-study confirms the long-term efficacy and safety of @entity4 in @entity0 with @entity1 lacking activating KIT mutations. @entity4 should be considered in select cases of @entity1 in whom MCs exhibit wild-type KIT.

title: Long-lasting complete response to @entity4 in a XXXX with systemic mastocytosis exhibiting wild type KIT.

answer: @entity0


abstract: STUDY OBJECTIVE: This systematic review aims to summarise the association between @entity4 ( @entity4 ) and @entity5 ( @entity5 ). DESIGN: MeSH terms and free text searches were performed on MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception to April 2015. Zetoc and OpenGrey databases were queried for grey literature, and lastly, hand searches were carried out. Study selection and quality assessment were conducted by two authors. One author carried out data extraction, which was checked by other authors. The relationships between @entity4 index (AHI), @entity3 desaturation index (ODI), time spent under 90% @entity3 saturation (% @entity2 <90), and minimum and mean @entity3 saturation ( @entity6 ) on @entity5 were examined. MEASUREMENT AND RESULTS: Two longitudinal and ten cross-sectional studies were included for our narrative synthesis, and seven studies for meta-analysis. Studies that performed multi-variable analysis demonstrated significant associations between @entity4 (assessed using either @entity4 index or ODI) and @entity5 in @entity1 ( @entity1 ). This was confirmed by meta-analysis (pooled OR 1.73, 95% CI: 1.13-2.64). There was some evidence to suggest that % @entity2 <90 may have an association with @entity5 . There was insufficient evidence to conclude on the relationship between minimum and mean @entity3 saturation on @entity5 . There was no evidence available on the associations between @entity4 and other respiratory parameters in type 1 @entity1 populations. CONCLUSION: There is moderate evidence that @entity4 is associated with @entity5 in @entity0 with @entity1 . Large prospective studies with long-term follow up are needed to assess the possible bi-directional mechanisms between @entity4 and @entity5 .

title: The Association between Obstructive Sleep Apnea on XXXX : A Systematic Review and Meta-Analysis.

answer: @entity5


abstract: STUDY OBJECTIVES: Recent studies have suggested that structural @entity4 may be linked with alterations in the @entity5 ( @entity5 ). This study compared cortical thickness and structural connectivity linked to the @entity5 in @entity0 with persistent @entity1 (PI) and @entity2 ( @entity2 ). METHODS: The current study used a clinical subsample from the longitudinal community-based Korean Genome and Epidemiology Study (KoGES). Cortical thickness and structural connectivity linked to the @entity5 in @entity0 with persistent @entity1 symptoms (PIS; n = 57) were compared to @entity2 ( @entity2 ; n = 40). All @entity0 underwent MRI acquisition. Based on literature review, we selected cortical regions corresponding to the @entity5 . A seed-based structural covariance analysis measured cortical thickness correlation between each seed region of the @entity5 and other cortical areas. Association of cortical thickness and covariance with sleep quality and neuropsychological assessments were further assessed. RESULTS: Compared to @entity2 , cortical thinning was found in PIS in the anterior cingulate cortex, precentral cortex, and lateral prefrontal cortex. Decreased structural connectivity between anterior and posterior regions of the @entity5 was observed in the PIS group. Decreased structural covariance within the @entity5 was associated with higher PSQI scores. Cortical thinning in the lateral frontal lobe was related to poor performance in executive function in PIS. CONCLUSION: Disrupted structural covariance network in PIS might reflect malfunctioning of antero-posterior disconnection of the @entity5 during the wake to sleep transition that is commonly found during normal sleep. The observed structural network alteration may further implicate commonly observed sustained sleep @entity3 in @entity1 .

title: Cortical Thinning and Altered Cortico-Cortical Structural Covariance of the Default Mode Network in @entity0 with XXXX .

answer: @entity1


abstract: STUDY OBJECTIVES: Recent studies have suggested that structural @entity4 may be linked with alterations in the @entity5 ( @entity5 ). This study compared cortical thickness and structural connectivity linked to the @entity5 in @entity0 with persistent @entity1 (PI) and @entity2 ( @entity2 ). METHODS: The current study used a clinical subsample from the longitudinal community-based Korean Genome and Epidemiology Study (KoGES). Cortical thickness and structural connectivity linked to the @entity5 in @entity0 with persistent @entity1 symptoms (PIS; n = 57) were compared to @entity2 ( @entity2 ; n = 40). All @entity0 underwent MRI acquisition. Based on literature review, we selected cortical regions corresponding to the @entity5 . A seed-based structural covariance analysis measured cortical thickness correlation between each seed region of the @entity5 and other cortical areas. Association of cortical thickness and covariance with sleep quality and neuropsychological assessments were further assessed. RESULTS: Compared to @entity2 , cortical thinning was found in PIS in the anterior cingulate cortex, precentral cortex, and lateral prefrontal cortex. Decreased structural connectivity between anterior and posterior regions of the @entity5 was observed in the PIS group. Decreased structural covariance within the @entity5 was associated with higher PSQI scores. Cortical thinning in the lateral frontal lobe was related to poor performance in executive function in PIS. CONCLUSION: Disrupted structural covariance network in PIS might reflect malfunctioning of antero-posterior disconnection of the @entity5 during the wake to sleep transition that is commonly found during normal sleep. The observed structural network alteration may further implicate commonly observed sustained sleep @entity3 in @entity1 .

title: Cortical Thinning and Altered Cortico-Cortical Structural Covariance of the Default Mode Network in XXXX with @entity1 .

answer: @entity0


abstract: OBJECTIVES: To evaluate the efficacy of short-duration, open-ended ureteral catheter drainage as a replacement to indwelling stent, and to study the effect of @entity3 on stent-induced @entity1 and storage symptoms following uncomplicated ureteroscopic removal of stones. DESIGN: Prospective randomised study. SETTING: School of Medical Sciences and Research, Sharda University, Greater Noida, India. @entity0 : @entity0 who underwent ureteroscopic removal of stones for lower ureteral stones between November 2011 and January 2014 were randomly assigned into three groups. @entity0 in group 1 (n=33) were stented with 5-French double J stent for 2 weeks. @entity0 in group 2 (n=35) were administered tablet @entity3 0.4 mg once daily for 2 weeks in addition to stenting, and those in group 3 (n=31) underwent 5-French open-ended ureteral catheter drainage for 48 hours. MAIN OUTCOME MEASURES: All @entity0 were evaluated for @entity2 using visual analogue scale scores at days 1, 2, 7, and 14, and for storage (irritative) bladder symptoms using International Prostate Symptom Score on days 7 and 14, and for quality-of-life score (using International Prostate Symptom Score) at day 14. RESULTS: Of the 99 @entity0 , visual analogue scale scores were significantly lower for groups 2 and 3 (P<0.0001). The International Prostate Symptom Scores for all parameters were lower in @entity0 from groups 2 and 3 compared to group 1 both at days 7 and 14 (P<0.0001). Analgesic requirements were similar in all three groups. CONCLUSION: Open-ended ureteral catheter drainage is equally effective and better tolerated than routine stenting following uncomplicated ureteroscopic removal of stones. @entity3 reduces storage symptoms and improves quality of life after ureteral stenting.

title: Comparison of efficacy and tolerance of short-duration open-ended ureteral catheter drainage and XXXX administration to indwelling double J stents following ureteroscopic removal of stones.

answer: @entity3


abstract: OBJECTIVE: A growing body of evidence supports an association between @entity4 and @entity2 . Coronary artery bypass grafting surgery is a treatment modality for suitable @entity0 with @entity3 ; however, patency rates of saphenous vein grafts (SVGs) are low. In this study we aimed to determine the association between @entity4 levels and the SVG disease. METHODS: The study population included 180 @entity0 who had undergone a primary coronary artery bypass grafting surgery with at least one SVG and later had a control angiography because of clinical indications. @entity0 were divided into two groups: 100 @entity0 with SVG disease and 80 of them with patent SVG. RESULTS: The mean age of 180 @entity0 was 57.4  8.8 years, and 64.4% of the study population were @entity0 . The total number of SVGs was 364, and the mean number of SVGs to each @entity0 was 2.02  0.61. @entity4 levels were higher in the patent SVG group than in the SVG disease group (36.2  10.7 and 21.1  10.4, respectively; P<0.001). @entity5 levels were significantly higher in the SVG disease group (8.3 vs. 6.5   mg/dl, P=0.001). In a multivariate regression analysis, current smoking, @entity1 , target artery diameter less than 1.5   mm, bypass time duration, and @entity4 levels remained as independent factors associated with SVG disease. CONCLUSION: Lower @entity4 levels are associated with occlusion of SVGs in @entity0 with @entity3 .

title: The relationship between XXXX levels and saphenous vein graft patency.

answer: @entity4


abstract: UNASSIGNED: Acne treatment by a mid-infrared laser may be unsatisfactory due to deeply situated acne-affected sebaceous glands which serve as its target. Skin manipulation by vacuum and contact cooling may improve laser-skin interaction, reduce @entity2 sensation, and increase overall safety and efficacy. To evaluate the safety and efficacy of acne treatment using an integrated cooling-vacuum-assisted 1540-nm erbium:glass laser, a prospective interventional study was conducted. It included 12 @entity0 (seven @entity0 and five @entity0 ) suffering from mild-to-moderate @entity3 . The device utilizes a mid-infrared 1540-nm laser (Alma Lasers Ltd. Caesarea, Israel), which is integrated with combined cooling-vacuum-assisted technology. An @entity1 is initially manipulated upon contact by a vacuum-cooling-assisted tip, followed by three to four stacked laser pulses (500-600  mJ, 4  mm spot size, and frequency of 2  Hz). @entity0 underwent four to six treatment sessions with a 2-week interval and were followed- @entity4  months after the last treatment. Clinical photographs were taken by high-resolution digital camera before and after treatment. Clinical evaluation was performed by two independent dermatologists, and results were graded on a scale of 0 (exacerbation) to 4 (76-100  % improvement). @entity0 ' and physicians' satisfaction was also recorded. @entity2 perception and adverse effects were evaluated as well. All @entity0 demonstrated a moderate to significant improvement (average score of 3.6 and 2.0 within 1 and 3  months, respectively, following last treatment session). No side effects, besides a transient erythema, were observed. Cooling-vacuum-assisted 1540-nm laser is safe and effective for the treatment of @entity3 .

title: Integrated cooling-vacuum-assisted 1540-nm erbium:glass laser is effective in treating mild-to-moderate XXXX .

answer: @entity3


abstract: BACKGROUND: Our previous in vitro studies have demonstrated dose-dependent effects of @entity5 ligands on hepatocyte cell death and proliferation. In the current study, we sought to determine if @entity5 ligand concentration is responsible for the divergent effects of these mediators on @entity2 after @entity1 /reperfusion injury and partial hepatectomy. METHODS: @entity0 models of partial @entity1 /reperfusion injury and hepatectomy were used to study the effect of @entity5 ligands on @entity2 . RESULTS: We found that hepatic expression of the @entity5 ligands, @entity4 ( @entity4 ) and keratinocyte-derived chemokine (KC), was significantly increased after both I/R injury and partial hepatectomy. However, expression of these ligands after I/R injury was 30-100-fold greater than after hepatectomy. Interestingly, the same pattern of expression was found in @entity3 following I/R injury with expression significantly greater in the @entity3 . In both systems, lower ligand expression was associated with increased hepatocyte proliferation and @entity2 in a @entity5 -dependent fashion. To confirm that these effects were related to ligand concentration, we administered exogenous @entity4 and KC to @entity0 undergoing partial hepatectomy. @entity0 received a "high" dose that replicated serum levels found after I/R injury and a "low" dose that was similar to that found after hepatectomy. @entity0 receiving the "high" dose had reduced levels of hepatocyte proliferation and regeneration whereas the "low" dose promoted hepatocyte proliferation and regeneration. CONCLUSIONS: Together, these data demonstrate that concentrations of CXC chemokines regulate the hepatic proliferative response and subsequent @entity2 .

title: CXC chemokines function as a rheostat for hepatocyte proliferation and XXXX .

answer: @entity2


abstract: The aim of this study was to establish an immunoprofile of @entity3 ( @entity3 ) and @entity4 ( @entity4 ), and to explore as first time in literature the possible correlation between maspin, @entity2 -1, @entity7 protein and angiogenesis in these @entity0 . For SCCs, the histological grade of differentiation was also taken into account. The angiogenesis was quantified in 38 randomly selected cases of SCCs and 17 BCCc, respectively, using the antibodies @entity6 ( @entity6 -A) and @entity5 , while the microvessel density (MVD) was evaluated with the CD31. RESULTS: In SCCs, maspin cytoplasm to nuclear shift was an indicator of a deeper tissue invasion and dedifferentiation in the invasion front. The poorly differentiated cases, compared to G1  G2-SCCs, expressed more frequent the markers @entity7 (30.77% vs. 8%) and @entity6 (53.85% vs. 32%), regardless the MVD. However, the @entity7 positivity was more frequent in BCCs than SCCs (52.94% vs. 15.79%). All of the @entity7 -positive @entity1 were located in the head and neck area. @entity2 -1 marked 21.05% of SCCs and 5.88% of BCCs, being directly correlated with @entity5 positivity. Eccrine glands and hair follicles also expressed @entity2 -1. CONCLUSIONS: In cutaneous SCCs located in the head and neck area, sun-dependent @entity7  @entity6 interaction seems to be responsible by @entity0 dedifferentiation, whereas maspin cytoplasm to nuclear shift might indicate a high degree of invasiveness. This is the first report about @entity2 -1 positivity in BCCs and eccrine glands, the significance of this pattern being unknown.

title: Correlation of angiogenesis with other immunohistochemical markers in cutaneous basal and XXXX .

answer: @entity3


abstract: Histone deacetylases (HDACs) regulate a broad range of biological processes through removal of acetyl groups from histones as well as non-histone proteins. Our previous studies showed that @entity4 and @entity5 are bound to promoters of key renal developmental regulators and that HDAC activity is required for embryonic kidney gene expression. However, the existence of many HDAC isoforms in embryonic kidneys raises questions concerning the possible specificity or redundancy of their functions. We report here that targeted deletion of both the @entity4 and @entity5 genes from the ureteric bud (UB) cell lineage of @entity2 causes bilateral @entity1 . One copy of either @entity4 or @entity5 is sufficient to sustain normal renal development. In addition to defective cell proliferation and survival, genome-wide transcriptional profiling revealed that the canonical Wnt signaling pathway is specifically impaired in UB( @entity4 ,2-/-) kidneys. Our results also demonstrate that loss of @entity4 and @entity5 in the UB epithelium leads to marked hyperacetylation of the @entity0 suppressor protein @entity3 on lysine 370, 379 and 383; these post-translational modifications are known to boost @entity3 stability and transcriptional activity. Genetic deletion of @entity3 partially rescues the development of UB( @entity4 ,2-/-) kidneys. Together, these data indicate that @entity4 and @entity5 are crucial for kidney development. They perform redundant, yet essential, cell lineage-autonomous functions via @entity3 -dependent and -independent pathways.

title: Histone deacetylase 1 and 2 regulate Wnt and XXXX pathways in the ureteric bud epithelium.

answer: @entity3


abstract: UNASSIGNED: Midline shift following severe @entity2 (sTBI) detected on computed tomography (CT) scans is an established predictor of poor outcome. We hypothesized that lateral ventricular volume (LVV) asymmetry is an earlier sign of developing asymmetric intracranial pathology than midline shift. This retrospective analysis was performed on data from 84 adults with blunt sTBI requiring a ventriculostomy who presented to a Level I @entity1 center. Seventy-six @entity0 underwent serial CTs within 3   h and an average of three scans within the first 10   d of sTBI. Left and right LVVs were quantified by computer-assisted manual volumetric measurements. LVV ratios (LVR) were determined on the admission CT to evaluate ventricular asymmetry. The relationship between the admission LVR value and subsequent midline shift development was tested using receiver operating characteristic (ROC) analysis, and odds ratio (OR) and relative risk tests. Sixty @entity0 had no >5   mm midline shift on the initial admission scan. Of these, 15 @entity0 developed it subsequently (16 @entity0 already had >5   mm midline shift on admission scans). For >5   mm midline shift development, admission LVR of >1.67 was shown to have a sensitivity of 73.3% and a specificity of 73.3% (area under the curve=0.782; p<0.0001). LVR of >1.67 as exposure yielded an OR of 7.56 (p<0.01), and a risk ratio of 4.42 (p<0.01) for midline shift development as unfavorable outcome. We propose that LVR captures LVV asymmetry and is not only related to, but also predicts the development of midline shift already at admission CT examination. Lateral ventricles may have a higher "compliance" than midline structures to developing asymmetric brain pathology. LVR analysis is simple, rapidly accomplished and may allow earlier interventions to attenuate midline shift and potentially improve ultimate outcomes.

title: Lateral Ventricle Volume Asymmetry Predicts Midline Shift in Severe XXXX .

answer: @entity2


abstract: 17 @entity0 (13 males and 4 females) were examined for side effects due to long-term treatment with @entity9 ( @entity6 ) with emphasis on alterations in @entity2 . 16 @entity0 were @entity1 , one @entity0 was diagnosed @entity5 e causa dubia. The age range was 25-68 years, with an average of 38.2 years. The daily @entity6 dose varied from 225 to 800 mg with a total intake during the trial period of 149.1-891.6 g yielding an average of 479.8 g. The treatment period varied from 20 to 51 months, with an average of 35.9 months. None of the @entity0 had to discontinue the treatment because of side effects. The laboratory data including hematological, and nephrological parameters revealed no significant changes related to @entity6 treatment within the treatment period. No changes were observed in ECG. 12 @entity0 experienced side effects, 8 of them receiving concomitant psycholeptic medication. 9 @entity0 complained of temporary fatigue and 5 of these experienced continuous drowsiness. There were 8 cases of @entity8 and two cases of increased appetite. One @entity0 developed light @entity4 and one @entity0 @entity3 . @entity6 is known to be an effective anti- @entity5 drug, but due to reports of @entity7 in 16 Finnish @entity0 the drug was withdrawn from the Danish market in 1975 although later its use was merely restricted to special cases. This study does not indicate that @entity6 contains greater risk of clinical side effects than commonly used psycholeptic drugs.

title: Evaluation of side effects due to XXXX in long-term treatment of @entity5 .

answer: @entity6


abstract: 17 @entity0 (13 males and 4 females) were examined for side effects due to long-term treatment with @entity9 ( @entity6 ) with emphasis on alterations in @entity2 . 16 @entity0 were @entity1 , one @entity0 was diagnosed @entity5 e causa dubia. The age range was 25-68 years, with an average of 38.2 years. The daily @entity6 dose varied from 225 to 800 mg with a total intake during the trial period of 149.1-891.6 g yielding an average of 479.8 g. The treatment period varied from 20 to 51 months, with an average of 35.9 months. None of the @entity0 had to discontinue the treatment because of side effects. The laboratory data including hematological, and nephrological parameters revealed no significant changes related to @entity6 treatment within the treatment period. No changes were observed in ECG. 12 @entity0 experienced side effects, 8 of them receiving concomitant psycholeptic medication. 9 @entity0 complained of temporary fatigue and 5 of these experienced continuous drowsiness. There were 8 cases of @entity8 and two cases of increased appetite. One @entity0 developed light @entity4 and one @entity0 @entity3 . @entity6 is known to be an effective anti- @entity5 drug, but due to reports of @entity7 in 16 Finnish @entity0 the drug was withdrawn from the Danish market in 1975 although later its use was merely restricted to special cases. This study does not indicate that @entity6 contains greater risk of clinical side effects than commonly used psycholeptic drugs.

title: Evaluation of side effects due to @entity6 in long-term treatment of XXXX .

answer: @entity5


abstract: While inventoring the local malacological fauna and evaluating the density of species acting as intermediate hosts of @entity0 schistosomes it has been shown that Bulinus truncatus is predominant in the study area. Bulinus globosus is scarcely encountered. Biomphalaria pfeifferi is only found in the Mayo Guerleo, in irrigation canals and draining ditches. But B. globosus and B. pfeifferi have not yet invaded the recent aquatic network and are not found in the lake nor in the newly created irrigation systems. Snails shedding cercariae of @entity4 and @entity1 have been collected in the area. Bulinus forskalii is found in all types of permanent of temporary waterbodies but S. intercalatum has not yet been reported from North-Cameroon. Lymnaea natalensis, the intermediate host of Fasciola gigantica, is found in the lake and in the canals, in the Mayo Guerleo and in the Toupasko pool. The @entity2 field does not form by itself a favorable environment for snails to develop in it. Spots where transmission occurare more often in the area the secondary of tertiary irrigation canals and the brains. The ditches obstructed by plants are the places where the snails are developing best. Bulinus spp. are found in large numbers in the lowest parts of the aquatic network and they accumulate there to survive drought conditions in the mud. The recently built irrigation systems are not massively invaded by the snails yet and the prevalence of @entity3 in the area correspond to the distribution of the intermediate hosts of schistosomes and to the density of the snails populations.

title: [Epidemiologic study of XXXX @entity3 in the @entity2 fields of Yagoua (North Cameroon) II. Distribution and ecology of intermediate hosts].

answer: @entity4


abstract: While inventoring the local malacological fauna and evaluating the density of species acting as intermediate hosts of @entity0 schistosomes it has been shown that Bulinus truncatus is predominant in the study area. Bulinus globosus is scarcely encountered. Biomphalaria pfeifferi is only found in the Mayo Guerleo, in irrigation canals and draining ditches. But B. globosus and B. pfeifferi have not yet invaded the recent aquatic network and are not found in the lake nor in the newly created irrigation systems. Snails shedding cercariae of @entity4 and @entity1 have been collected in the area. Bulinus forskalii is found in all types of permanent of temporary waterbodies but S. intercalatum has not yet been reported from North-Cameroon. Lymnaea natalensis, the intermediate host of Fasciola gigantica, is found in the lake and in the canals, in the Mayo Guerleo and in the Toupasko pool. The @entity2 field does not form by itself a favorable environment for snails to develop in it. Spots where transmission occurare more often in the area the secondary of tertiary irrigation canals and the brains. The ditches obstructed by plants are the places where the snails are developing best. Bulinus spp. are found in large numbers in the lowest parts of the aquatic network and they accumulate there to survive drought conditions in the mud. The recently built irrigation systems are not massively invaded by the snails yet and the prevalence of @entity3 in the area correspond to the distribution of the intermediate hosts of schistosomes and to the density of the snails populations.

title: [Epidemiologic study of @entity4 @entity3 in the XXXX fields of Yagoua (North Cameroon) II. Distribution and ecology of intermediate hosts].

answer: @entity2


abstract: While inventoring the local malacological fauna and evaluating the density of species acting as intermediate hosts of @entity0 schistosomes it has been shown that Bulinus truncatus is predominant in the study area. Bulinus globosus is scarcely encountered. Biomphalaria pfeifferi is only found in the Mayo Guerleo, in irrigation canals and draining ditches. But B. globosus and B. pfeifferi have not yet invaded the recent aquatic network and are not found in the lake nor in the newly created irrigation systems. Snails shedding cercariae of @entity4 and @entity1 have been collected in the area. Bulinus forskalii is found in all types of permanent of temporary waterbodies but S. intercalatum has not yet been reported from North-Cameroon. Lymnaea natalensis, the intermediate host of Fasciola gigantica, is found in the lake and in the canals, in the Mayo Guerleo and in the Toupasko pool. The @entity2 field does not form by itself a favorable environment for snails to develop in it. Spots where transmission occurare more often in the area the secondary of tertiary irrigation canals and the brains. The ditches obstructed by plants are the places where the snails are developing best. Bulinus spp. are found in large numbers in the lowest parts of the aquatic network and they accumulate there to survive drought conditions in the mud. The recently built irrigation systems are not massively invaded by the snails yet and the prevalence of @entity3 in the area correspond to the distribution of the intermediate hosts of schistosomes and to the density of the snails populations.

title: [Epidemiologic study of @entity4 XXXX in the @entity2 fields of Yagoua (North Cameroon) II. Distribution and ecology of intermediate hosts].

answer: @entity3


abstract: Milk intake and nipple @entity1 were studied in the natural suckling situation after gastrointestinal preloading. @entity0 pups, deprived of their dam for 9 hr at 1, 10, or 20 days of age, were preloaded by gavage with volumes ranging from 2 to 16% of their body weight and returned to suckle. Preloads of artificial bitch's milk decreased the intake of mother's milk in a volume-related manner at all ages. At 1 and 10 days 4% preloads decreased milk intake without affecting @entity1 ; larger preloads of 8 and 16% decreased intake and reduced the incidence of attachment. At 20 days of age small and large preloads decreased both incidence of attachment and milk intake. Preloads up to 8% of body weight had no effect on latency to attach at any age. Complete subdiaphragmatic bilateral vagotomy increased milk intake of 7-9 day-old pups fed automatically through an @entity2 in a nonsuckling situation. Vagotomy combined with spinal cordotomy (T2-T3) resulted in a synergistic @entity3 and massive distension of the upper GI tract. The results indicate that suckling @entity0 can control their intake of mother's milk while remaining attached to a nipple as early as 1 day of age. The suppression of ingestion in response to GI filling appears to be mediated by visceral afferent activity. Conversely, @entity1 are less affected by GI fill. This suggests that @entity1 and @entity1 have different controls during the 1st 10 days of postnatal development.

title: Differential effects of upper gastrointestinal fill on milk ingestion and nipple attachment in the suckling XXXX .

answer: @entity0


abstract: BACKGROUND: @entity4 (CA) has been widely applied in medicine and food preservation. However, whether and how CA regulates plant physiology is largely unknown. To address these gaps, the present study investigated the beneficial effect of CA on root branching and its possible biochemical mechanism. RESULTS: The @entity1 ( @entity1 ) formation of pepper seedlings could be markedly induced by CA at specific concentrations without any inhibitory effect on primary root (PR) growth. CA could induce the generation of endogenous @entity2 ( @entity3 ) by increasing the activity of @entity0 desulfhydrase in roots. By fluorescently tracking endogenous @entity3 in situ, it could be clearly observed that @entity3 accumulated in the outer layer cells of the PR where LRs emerge. @entity5 ( @entity3 donor) treatment induced @entity1 formation, while @entity6 ( @entity3 scavenger) showed an adverse effect. The addition of @entity6 mitigated the CA-induced increase in endogenous @entity3 level, which in turn counteracted the inducible effect of CA on @entity1 formation. CONCLUSION: CA showed great potential in promoting @entity1 formation, which was mediated by endogenous @entity3 . These results not only shed new light on the application of CA in agriculture but also extend the knowledge of @entity3 signaling in the regulation of root branching.    2015 Society of Chemical Industry.

title: @entity4 promotes root branching by regulating endogenous XXXX .

answer: @entity2


abstract: BACKGROUND: @entity4 (CA) has been widely applied in medicine and food preservation. However, whether and how CA regulates plant physiology is largely unknown. To address these gaps, the present study investigated the beneficial effect of CA on root branching and its possible biochemical mechanism. RESULTS: The @entity1 ( @entity1 ) formation of pepper seedlings could be markedly induced by CA at specific concentrations without any inhibitory effect on primary root (PR) growth. CA could induce the generation of endogenous @entity2 ( @entity3 ) by increasing the activity of @entity0 desulfhydrase in roots. By fluorescently tracking endogenous @entity3 in situ, it could be clearly observed that @entity3 accumulated in the outer layer cells of the PR where LRs emerge. @entity5 ( @entity3 donor) treatment induced @entity1 formation, while @entity6 ( @entity3 scavenger) showed an adverse effect. The addition of @entity6 mitigated the CA-induced increase in endogenous @entity3 level, which in turn counteracted the inducible effect of CA on @entity1 formation. CONCLUSION: CA showed great potential in promoting @entity1 formation, which was mediated by endogenous @entity3 . These results not only shed new light on the application of CA in agriculture but also extend the knowledge of @entity3 signaling in the regulation of root branching.    2015 Society of Chemical Industry.

title: XXXX promotes root branching by regulating endogenous @entity2 .

answer: @entity4


abstract: PURPOSE: To report the initial experience, clinical outcomes, and safety profile of 27 gauge pars plana vitrectomy ( @entity7 ) in eyes with @entity4 . DESIGN: Multicenter, retrospective, interventional case series. METHODS: setting: Private practice and tertiary care settings. STUDY POPULATION: Eyes undergoing 27 gauge @entity7 for a vitreoretinal surgery indication. INTERVENTION: Three-port, transconjunctival 27 gauge @entity7 . MAIN OUTCOME MEASURES: Change in visual acuity and occurrence of @entity1 with minimum follow-up of 90  days. RESULTS: Ninety-five eyes met the inclusion criteria. Surgical indications included epiretinal membrane (n  = 26), @entity5 (n  = 14), full-thickness macular hole (n  = 11), @entity5 with (n  = 7) or without (n  = 9) proliferative @entity6 (PVR), @entity2 (n  = 10), vitreous opacities (n  = 8), @entity9 (n  = 4), sub-silicone oil retinal detachment (n  = 3), retained lens material (n  = 1), submacular @entity2 (n  = 1), and aqueous misdirection (n  = 1). Mean logMAR visual acuity improved from 1.08    0.71 (20/240 Snellen equivalent) preoperatively to 0.53    0.65 (20/67 Snellen equivalent) postoperatively (P < .001). Mean follow-up was 144  days (median 127  days, range 90-254  days). There were no intraoperative complications and no case required conversion to 20, 23, or 25 gauge instrumentation. A total of 3 sclerotomy sites (1.1%) were sutured at the conclusion of surgery. @entity1 included transient @entity8 in 8 eyes (8.4%), transient @entity10 in 5 eyes (5.3%), and @entity2 in 5 eyes (5.3%). No cases of @entity0 , sclerotomy-related @entity3 , or @entity5 were encountered in the follow-up period. CONCLUSION: The 27 gauge @entity7 was well tolerated with low rates of @entity1 across varied surgical indications.

title: Outcomes of 27 Gauge Microincision Vitrectomy Surgery for XXXX .

answer: @entity4


abstract: OBJECTIVE: The objective of this study was to determine the incidence of and specific preoperative and intraoperative risk factors for @entity5 ( @entity5 ) in electively treated vascular surgery @entity0 . METHODS: Between March 2010 and November 2013, all vascular surgery @entity0 were included in a prospective database. Various preoperative, intraoperative, and postoperative risk factors were collected during hospitalization. The primary outcome variable was the incidence of @entity5 . Secondary outcome variables were any surgical complication, hospital length of stay, and mortality. RESULTS: In total, 566 @entity0 were prospectively evaluated; 463 @entity0 were 60  years or older at the time of surgery and formed our study cohort. The median age was 72  years (interquartile range, 66-77), and 76.9% were male. Twenty-two @entity0 (4.8%) developed @entity5 . Factors that differed significantly by univariate analysis included current smoking (P  = .001), increased comorbidity (P  = .001), @entity3 (P  = .003), @entity1 (P  = .001), @entity2 (P  < .001), open aortic surgery or amputation surgery (P  < .001), elevated C-reactive protein level (P  < .001), and @entity4 (P  < .001). Multivariate logistic regression analysis revealed preoperative @entity2 (odds ratio [OR], 16.4; 95% confidence interval [CI], 4.7-57.0), open aortic surgery or amputation surgery (OR, 14.0; 95% CI, 3.9-49.8), current smoking (OR, 10.5; 95% CI, 2.8-40.2), @entity3 (OR, 7.6; 95% CI, 1.9-30.5) and age >= 80  years (OR, 7.3; 95% CI, 1.8-30.1) to be independent predictors of the occurrence of @entity5 . The combination of these parameters allows us to predict @entity6 with a sensitivity of 86% and a specificity of 92%. The area under the curve of the corresponding receiver operating characteristics was 0.93. @entity6 was associated with longer hospital length of stay (P  < .001), more frequent and increased intensive care unit stays (P  = .008 and P  = .003, respectively), more surgical complications (P  < .001), more postdischarge institutionalization (P  < .001), and higher 1-year mortality rates (P  = .0026). CONCLUSIONS: In vascular surgery @entity0 , preoperative @entity2 and open aortic or amputation surgery were highly significant risk factors for the occurrence of @entity5 . In addition, @entity5 was significantly associated with a higher mortality and more institutionalization. @entity0 with these risk factors should be considered for high-standard @entity6 care to improve these outcomes.

title: Predicting XXXX after vascular surgical procedures.

answer: @entity5


abstract: KEY POINTS: Physical inactivity increases the risk of @entity1 and may alter sympathetic nervous system control of vascular resistance. Hindlimb unweighting (HU), a rodent model of physical inactivity, has been shown to diminish sympathetic vasoconstrictor responsiveness and reduce NO synthase expression in isolated skeletal muscle blood vessels. Our understanding of the effects of HU on sympathetic vascular regulation in vivo is very limited. The present findings demonstrate that HU did not alter sympathetic vasoconstrictor responsiveness and NO-mediated inhibition of sympathetic vasoconstriction in resting and contracting skeletal muscle. This study suggests that short-term physical inactivity does not alter in vivo sympathetic vascular control in the skeletal muscle vascular bed at rest and during contraction. ABSTRACT: We tested the hypothesis that physical inactivity would increase sympathetic vasoconstrictor responsiveness and diminish NO-mediated inhibition of sympathetic vasoconstriction in resting and contracting skeletal muscle. @entity0 (n  =  33) were randomly assigned to sedentary time control (S) or hindlimb unweighted (HU) groups for 21  days. Following the intervention, @entity0 were anaesthetized and instrumented for measurement of arterial blood pressure and femoral artery blood flow and stimulation of the lumbar sympathetic chain. The percentage change of femoral vascular conductance (%FVC) in response to sympathetic chain stimulation delivered at 2 and 5  Hz was determined at rest and during triceps surae muscle contraction before (control) and after NO synthase blockade with @entity4 (5  mg  kg  i.v.). Sympathetic vasoconstrictor responsiveness was not different (P  >  0.05) in S and HU @entity0 at rest (S, 2  Hz, -26      8% and 5  Hz, -46      12%; and HU, 2  Hz, -29      9% and 5  Hz, -51      10%) and during contraction (S, 2  Hz, -10      7% and 5  Hz, -23      11%; and HU, 2  Hz, -9      5% and 5  Hz, -22      7%). @entity2 synthase blockade caused a similar increase (P  >  0.05) in sympathetic vasoconstrictor responsiveness in HU and S @entity0 at rest (S, 2  Hz, -41      7% and 5  Hz, -58      8%; and HU, 2  Hz, -43      6% and 5  Hz, -63      8%) and during muscle contraction (S, 2  Hz, -15      6% and 5  Hz, -31      11%; and HU, 2  Hz, -12      5% and 5  Hz, -29      8%). Skeletal muscle NO synthase expression and @entity3 -mediated vasodilatation were also not different between HU and S @entity0 . These data suggest that HU does not alter sympathetic vasoconstrictor responsiveness and NO-mediated inhibition of sympathetic vasoconstriction in resting and contracting skeletal muscle.

title: Hindlimb unweighting does not alter vasoconstrictor responsiveness and XXXX -mediated inhibition of sympathetic vasoconstriction.

answer: @entity2


abstract: Twenty-eight @entity0 (22 @entity0 , six @entity0 ) underwent transsphenoidal microsurgery for suspected @entity4 -secreting @entity2 . @entity3 was present in 19 of the 22 @entity0 , and @entity5 , in 21 of the 22 @entity0 and two of the six @entity0 . @entity4 values preoperatively ranged from 62 to 38,130 ng/ml, and the mean percentage decrease in serum @entity4 ( @entity4 ) after surgery was 80% (range: 38% to 99%). Twenty @entity0 had microadenomas ( @entity1 less than 10 mm), and seven had macroadenomas (greater than 10 mm). Although no @entity1 was found in one patient, her serum @entity4 fell from 65 to 24 ng/ml postoperatively. Surgical results depended upon both the initial @entity4 level and the @entity1 size. All eight @entity0 with @entity1 of less than 10 mm and @entity4 levels of less than 200 ng/ml had normal postoperative @entity4 values, whereas serum @entity4 returned to normal in only four of eleven @entity0 with microadenomas but with preoperative @entity4 of greater than 200 ng/ml. None of the five @entity0 with macroadenomas in who serum @entity4 had been measured preoperatively had normalization of serum @entity4 postoperatively, including one @entity0 with a preoperative level of less than 200 ng/ml. Menses resumed in 11 of 18 @entity0 ; @entity5 improved in six of 11 subjects, and nine pregnancies have occurred. Analysis of these data, as well as those of 12 published series, suggests that both @entity1 size and the preoperative serum @entity4 level are important factors in predicting the success of surgical therapy. Longitudinal follow-up is imperative to determine which @entity0 are truly cured.

title: Transsphenoidal surgery for XXXX -secreting @entity2 : a study of 28 cases and review of the literature.

answer: @entity4


abstract: Twenty-eight @entity0 (22 @entity0 , six @entity0 ) underwent transsphenoidal microsurgery for suspected @entity4 -secreting @entity2 . @entity3 was present in 19 of the 22 @entity0 , and @entity5 , in 21 of the 22 @entity0 and two of the six @entity0 . @entity4 values preoperatively ranged from 62 to 38,130 ng/ml, and the mean percentage decrease in serum @entity4 ( @entity4 ) after surgery was 80% (range: 38% to 99%). Twenty @entity0 had microadenomas ( @entity1 less than 10 mm), and seven had macroadenomas (greater than 10 mm). Although no @entity1 was found in one patient, her serum @entity4 fell from 65 to 24 ng/ml postoperatively. Surgical results depended upon both the initial @entity4 level and the @entity1 size. All eight @entity0 with @entity1 of less than 10 mm and @entity4 levels of less than 200 ng/ml had normal postoperative @entity4 values, whereas serum @entity4 returned to normal in only four of eleven @entity0 with microadenomas but with preoperative @entity4 of greater than 200 ng/ml. None of the five @entity0 with macroadenomas in who serum @entity4 had been measured preoperatively had normalization of serum @entity4 postoperatively, including one @entity0 with a preoperative level of less than 200 ng/ml. Menses resumed in 11 of 18 @entity0 ; @entity5 improved in six of 11 subjects, and nine pregnancies have occurred. Analysis of these data, as well as those of 12 published series, suggests that both @entity1 size and the preoperative serum @entity4 level are important factors in predicting the success of surgical therapy. Longitudinal follow-up is imperative to determine which @entity0 are truly cured.

title: Transsphenoidal surgery for @entity4 -secreting XXXX : a study of 28 cases and review of the literature.

answer: @entity2


abstract: PURPOSE: MR safety at 7 Tesla relies on accurate numerical simulations of transmit electromagnetic fields to fully assess local specific absorption rate (SAR) safety. Numerical simulations for SAR safety are currently performed using models of healthy @entity0 . These simulations might not be useful for estimating SAR in @entity0 who have large lesions with potentially abnormal dielectric properties, e.g., @entity2 . THEORY AND METHODS: In this study, @entity2 @entity0 models are constructed based on scans of four @entity0 with high grade @entity2 . Dielectric properties for the modeled @entity1 are assigned based on electrical properties tomography data for the same @entity0 . Simulations were performed to determine SAR. RESULTS: Local SAR increases in the @entity1 by as much as 30%. However, the location of the maximum 10-gram averaged SAR typically occurs outside of the @entity1 , and thus does not increase. In the worst case, if the @entity1 model is moved to the location of maximum electric field intensity, then we do observe an increase in the estimated peak 10-gram SAR directly related to the @entity1 . CONCLUSION: Peak local SAR estimation made on the results of a healthy @entity0 model simulation may underestimate the true peak local SAR in a @entity2 @entity0 . Magn Reson Med, 2015.    2015 Wiley Periodicals, Inc.

title: Local specific absorption rate in XXXX at 7 tesla.

answer: @entity2


abstract: UNASSIGNED: Background. In 2002, the Danish @entity2 Society opened a rehabilitation centre in which @entity2 @entity1 were offered a free, six-day, multidimensional residential course. Our previous studies of the effects of this course at one and six months of follow-up showed no positive effect on distress. We investigated long-term effects at 12 months of follow-up and whether subgroups with fewer psychosocial resources received more benefit from the intervention than @entity1 with better resources. Material and methods. In two Danish counties, 507 @entity1 with @entity0 diagnosed within the past two years who had completed primary treatment were randomised to a six-day, multidimensional residential rehabilitation course or to standard care. Of these, 208 @entity1 received the allocated intervention and 244 received the allocated control condition and were included in the analyses. @entity1 in both groups completed questionnaires at baseline and at one, six and 12 months of follow-up, including the 'Profile of Mood States short form', the 'General Self-efficacy' scale and a question on emotional support. At 12 months of follow-up, 179 @entity1 in the intervention group and 195 in the control group provided data. Results. No effect of the intervention was found on distress at 12 months of follow-up, even in subgroups with fewer psychosocial resources at baseline, i.e. greater baseline distress, poorer self-efficacy and less emotional support. Conclusion. Multidimensional rehabilitation programmes may not be effective in the treatment of distress. During the past few decades, studies of psychotherapy or psycho-education in @entity2 @entity1 have shown small to moderate effects. More focused rehabilitation programmes may be more effective.

title: Distress after a XXXX rehabilitation course. Main effects and effect modification in a randomised trial at 12 months of follow-up.

answer: @entity2


abstract: Salt treatment of the cytoplasmic @entity0 -receptor complex from @entity2 oviduct induces a strong affinity of the complex for DNA-cellulose and @entity3 . This process is called activation. Binding to heparin- and lysozyme-sepharose is also observed with the untreated complex. But, the salt treatment, additional binding of the complex to these adsorbents is seen. The increased ability of the complex to bind to polyanions and polycations is destroyed by mild trypsination. The binding to the hydrophobic adsorbent is not affected by this treatment. Neither a change of the sedimentation constant nor of the size of the receptor protein is observed after salt treatment in the cold. After binding of the salt-activated @entity0 -receptor complex to DNA-cellulose in the cold, an increase of its sedimentation constant and its size, as measured by density-gradient centrifugation and agarose gel chromatography, resp., becomes apparent. A similar phenomenon is observed after binding to DEAE-cellulose and to some extent after binding to heparin-sepharose. The nuclear complex seems to have the same sedimentation constant as the cytoplasmic complex eluted from DNA-cellulose. The sedimentation constant of the nuclear complex is not changed after DNA-cellulose chromatography. The cytoplasmic @entity1 -receptor complex from the same tissue, i.e. the oviduct, does not show any change of size. Thus the well-known process of transformation can now be separated into 2 steps. (1) Activation of the @entity0 -receptor complex for its binding to various adsorbents in vitro and probably to its acceptor site(s) in vivo. (2) Increase of receptor size. This second step seems to be a special property of the @entity0 -receptor complex. Its physiological significance is unclear.

title: Transformation of the estrogen-receptor complex from XXXX oviduct in 2 steps.

answer: @entity2


abstract: OBJECTIVE: Isolation of specific bacteria from @entity0 intestinal microflora to convert naringin to naringenin efficiently. METHODS: Fresh @entity0 feces from healthy individual was cultured in an anaerobic chamber for 24 h before being diluted and spread on agar medium. We cultured and incubated each single colony with the substrate naringin. The biotransformation of naringin by each single colony was detected by high-performance liquid chromatography (HPLC). We identified the isolated bacteria based on the analyses of 16S rDNA sequence and biochemical traits. We also studied the bioconversion kinetics of the bacteria. RESULTS: Four bacterial strains, named @entity1 -JLD3, @entity1 , @entity1 -JLD104 and @entity1 -JLD109, capable of biotransforming naringin to naringenin, were isolated and identified as Blautia sp. @entity1 -JLD3, Enterococcus sp. @entity1 , Bacteroides sp. @entity1 -JLD104 and @entity2 . @entity1 -JLD109 respectively based on the 16S rDNA sequence analysis, bacterial cell morphology, and biochemical traits. Study on biotransforming kinetics showed that all the four isolated bacterial strains were able to convert naringin (0.2 mmol/L) to naringenin within 12 h. The maximal concentration of the substrate naringin that strain @entity1 -JLD3, strain @entity1 , strain @entity1 -JLD104 and strain @entity1 -JLD109 could biotransform efficiently were 0. 2 mmol/L (the average biotransforming rate was 66. 67%), 0.8 mmol/L (the average biotransforming rate was 86.49%), 0. 2 mmol/L (the average biotransforming rate was 73.68%) and 1.6 mmol/L (the average biotransforming rate was 93.20%), respectively. CONCLUSION: The four bacterial strains were capable of biotransforming naringin to naringenin, among which @entity2 . @entity1 -JLD109 has the highest naringin biotransforming capacity.

title: [Isolation, identification and naringin biotransforming properties of naringinase producing bacteria isolated from XXXX intestinal microflora].

answer: @entity0


abstract: OBJECTIVE: @entity3 is one of the most serious diseases and a common problem in various stages marine culture including @entity5 culture of southern China. The isolation and identification of pathogenic bacteria from @entity5 will be useful for monitoring of drug resistance and controlling the outbreak and spread of @entity3 in @entity5 . The purpose of this study was to characterize the pathogen of @entity5 . METHODS: The pathogenic bacteria separated from the liver and kidney of diseased fish were identified through pure culture, artificial @entity1 , automatic tests in bacteriology automatic identification, drug sensitive tests, morphometry, and physiological and biochemical determination. RESULTS: The strains were characterized and identified as @entity6 . Two strain were selected for virulence tests and all the moribund/dead fish exhibited @entity3 as that observed in natural outbreak. Drug sensitive tests show that @entity6 was highly resistant to 3 agents including @entity0 , whereas sensitive to 5 agents including @entity4 . Histopathological changes were mainly shown as @entity2 as a result of inflammatory cell infiltration in the diseased tissue. CONCLUSION: The biochemical, physiological tests confirm that @entity6 is the pathogen causing @entity5 vibriosis. The multi-drug resistance among @entity6 suggests strengthened monitoring of outbreaks of @entity6 caused disease in @entity5 culture.

title: [Biological characteristics and histopathological observation of XXXX from diseased fish].

answer: @entity6