abstract: UNASSIGNED: Currently, the lack of awareness of deficits, i.e., @entity4 , is a major obstacle in the healthcare circuit that delays the diagnosis of @entity2 ( @entity2 ). However, a clear framework is lacking in the literature related to this phenomenon in terms of its definition, mechanisms, and objects. The aim of this study is to assess the different levels of @entity1 using a prediction-performance procedure and to identify the potential correlates of these levels. A  sample of @entity0 with probable @entity2 was divided into three groups according to the severity of @entity3 (mild (MiD), moderate (MoD), and moderately severe ( @entity5 ) @entity3 ), ranked according to the results of the Mini-Mental State Examination. We observed the following three scores: the real score, the prediction score, and the @entity4 score. These scores were calculated based on the prediction-performance task MISAwareness from the @entity3 Rating Scale for cognitive processes (i.e., Attention, Initiation, Conceptualization, Construction, and Memory). We obtained a strong plateau effect between the MiD and MoD groups for @entity4 scores for actual performance or prediction for both the level of overall functioning and for specific processes. The sole exception was the result for memory processes. Moreover, the profiles of the @entity0 ' responses on the Memory subscale were substantially different and, indeed, opposite from those for the other processes. The main results confirm the multidimensionality of @entity4 and its variability with the stage of @entity3 and specifically implicate memory processes that indicate a cleavage between memory and other cognitive functions.

title: Heterogeneity of @entity1 and  its Variation with the Severity of  @entity3 in @entity0 with XXXX .

answer: @entity2


abstract: UNASSIGNED: Currently, the lack of awareness of deficits, i.e., @entity4 , is a major obstacle in the healthcare circuit that delays the diagnosis of @entity2 ( @entity2 ). However, a clear framework is lacking in the literature related to this phenomenon in terms of its definition, mechanisms, and objects. The aim of this study is to assess the different levels of @entity1 using a prediction-performance procedure and to identify the potential correlates of these levels. A  sample of @entity0 with probable @entity2 was divided into three groups according to the severity of @entity3 (mild (MiD), moderate (MoD), and moderately severe ( @entity5 ) @entity3 ), ranked according to the results of the Mini-Mental State Examination. We observed the following three scores: the real score, the prediction score, and the @entity4 score. These scores were calculated based on the prediction-performance task MISAwareness from the @entity3 Rating Scale for cognitive processes (i.e., Attention, Initiation, Conceptualization, Construction, and Memory). We obtained a strong plateau effect between the MiD and MoD groups for @entity4 scores for actual performance or prediction for both the level of overall functioning and for specific processes. The sole exception was the result for memory processes. Moreover, the profiles of the @entity0 ' responses on the Memory subscale were substantially different and, indeed, opposite from those for the other processes. The main results confirm the multidimensionality of @entity4 and its variability with the stage of @entity3 and specifically implicate memory processes that indicate a cleavage between memory and other cognitive functions.

title: Heterogeneity of @entity1 and  its Variation with the Severity of  XXXX in @entity0 with @entity2 .

answer: @entity3


abstract: UNASSIGNED: Currently, the lack of awareness of deficits, i.e., @entity4 , is a major obstacle in the healthcare circuit that delays the diagnosis of @entity2 ( @entity2 ). However, a clear framework is lacking in the literature related to this phenomenon in terms of its definition, mechanisms, and objects. The aim of this study is to assess the different levels of @entity1 using a prediction-performance procedure and to identify the potential correlates of these levels. A  sample of @entity0 with probable @entity2 was divided into three groups according to the severity of @entity3 (mild (MiD), moderate (MoD), and moderately severe ( @entity5 ) @entity3 ), ranked according to the results of the Mini-Mental State Examination. We observed the following three scores: the real score, the prediction score, and the @entity4 score. These scores were calculated based on the prediction-performance task MISAwareness from the @entity3 Rating Scale for cognitive processes (i.e., Attention, Initiation, Conceptualization, Construction, and Memory). We obtained a strong plateau effect between the MiD and MoD groups for @entity4 scores for actual performance or prediction for both the level of overall functioning and for specific processes. The sole exception was the result for memory processes. Moreover, the profiles of the @entity0 ' responses on the Memory subscale were substantially different and, indeed, opposite from those for the other processes. The main results confirm the multidimensionality of @entity4 and its variability with the stage of @entity3 and specifically implicate memory processes that indicate a cleavage between memory and other cognitive functions.

title: Heterogeneity of @entity1 and  its Variation with the Severity of  @entity3 in XXXX with @entity2 .

answer: @entity0


abstract: UNASSIGNED: @entity9 ( @entity9 ) accounts for approximately 15-20% of all @entity3 worldwide. While the majority of SCDs occur in adults, @entity0 , and adults <35 years (<1%) may also be affected. Currently the most effective strategy for both primary and secondary prevention of @entity9 is the @entity5 ( @entity5 ). However, identification of @entity0 who will benefit from @entity5 implantation remains challenging. @entity8 ( @entity8 ) is the most frequent imaging parameter used to select @entity0 for @entity5 implantation for primary prevention. However, @entity8 has shown to be suboptimal for prediction of benefit. Non-invasive cardiac imaging permits characterization of the arrhythmogenic substrate, including dispersion of electromechanical activation, presence of @entity4 , and cardiac innervation status. The arrhythmogenic substrate may change across the different underlying diseases. While in @entity4 , differentiation and characterization of @entity10 core and peri- @entity10 zone have been shown to refine the risk stratification of @entity0 , in non-ischemic @entity4 , the substrate may be more heterogeneous and tissue characterization assessing focal and diffuse @entity2 and @entity1 processes may be more relevant. Furthermore, in channelopathies, assessment of mechanical dispersion between @entity4 may identify the @entity0 with increased risk of @entity7 . Finally, potential triggers of @entity7 such as @entity6 can be evaluated. The role of noninvasive imaging in the risk stratification of @entity9 and the selection of candidates for @entity5 will be discussed in this article.

title: Noninvasive imaging markers associated with XXXX .

answer: @entity9


abstract: CONTEXT: Exercise could be beneficial for @entity3 survivors. However, no systematic review across @entity1 stages and treatment types addressing potential benefits and harms exists to date. OBJECTIVE: To assess the effects of exercise on @entity1 -specific quality of life and adverse events in @entity3 trials. EVIDENCE ACQUISITION: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, AMED, CINAHL, PsycINFO, SPORTDiscus, and PEDro. We also searched grey literature databases, including trial registers. Searches were from database inception to March 2015. Standardised mean differences (SMDs) were calculated for meta-analysis. EVIDENCE SYNTHESIS: We included 16 randomised controlled trials (RCTs) involving 1574 @entity0 with @entity3 . Follow-up varied from 8 wk to 12 mo. RCTs involved @entity0 with stage I-IV @entity1 . A high risk of bias was frequently due to problematic intervention adherence. Seven trials involving 912 @entity0 measured @entity1 -specific quality of life. Pooling of the data from these seven trials revealed no significant effect on this outcome ( @entity7 0.13, 95% confidence interval [CI] -0.08 to 0.34, median follow-up 12 wk). Sensitivity analysis of studies that were judged to be of high quality indicated a moderate positive effect estimate ( @entity7 0.33, 95% CI 0.08-0.58; median follow-up 12 wk). Similar beneficial effects were seen for @entity1 , submaximal @entity4 , and lower body strength. We found no evidence of benefit for disease progression, @entity2 , or sexual function. There were no deaths attributable to exercise interventions. Other serious adverse events (eg, @entity5 ) were equivalent to those seen in controls. CONCLUSIONS: These results support the hypothesis that exercise interventions improve @entity1 -specific quality of life, @entity1 , submaximal @entity4 , and lower body strength. @entity0 SUMMARY: This review shows that exercise/physical activity interventions can improve quality of life, @entity6 , @entity4 , and function for @entity0 with @entity3 .

title: Exercise for @entity0 with XXXX : A Systematic Review and Meta-analysis.

answer: @entity3


abstract: CONTEXT: Exercise could be beneficial for @entity3 survivors. However, no systematic review across @entity1 stages and treatment types addressing potential benefits and harms exists to date. OBJECTIVE: To assess the effects of exercise on @entity1 -specific quality of life and adverse events in @entity3 trials. EVIDENCE ACQUISITION: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, AMED, CINAHL, PsycINFO, SPORTDiscus, and PEDro. We also searched grey literature databases, including trial registers. Searches were from database inception to March 2015. Standardised mean differences (SMDs) were calculated for meta-analysis. EVIDENCE SYNTHESIS: We included 16 randomised controlled trials (RCTs) involving 1574 @entity0 with @entity3 . Follow-up varied from 8 wk to 12 mo. RCTs involved @entity0 with stage I-IV @entity1 . A high risk of bias was frequently due to problematic intervention adherence. Seven trials involving 912 @entity0 measured @entity1 -specific quality of life. Pooling of the data from these seven trials revealed no significant effect on this outcome ( @entity7 0.13, 95% confidence interval [CI] -0.08 to 0.34, median follow-up 12 wk). Sensitivity analysis of studies that were judged to be of high quality indicated a moderate positive effect estimate ( @entity7 0.33, 95% CI 0.08-0.58; median follow-up 12 wk). Similar beneficial effects were seen for @entity1 , submaximal @entity4 , and lower body strength. We found no evidence of benefit for disease progression, @entity2 , or sexual function. There were no deaths attributable to exercise interventions. Other serious adverse events (eg, @entity5 ) were equivalent to those seen in controls. CONCLUSIONS: These results support the hypothesis that exercise interventions improve @entity1 -specific quality of life, @entity1 , submaximal @entity4 , and lower body strength. @entity0 SUMMARY: This review shows that exercise/physical activity interventions can improve quality of life, @entity6 , @entity4 , and function for @entity0 with @entity3 .

title: Exercise for XXXX with @entity3 : A Systematic Review and Meta-analysis.

answer: @entity0


abstract: Dystrophinopathies are due to mutations in the @entity10 gene on chromosome Xp21.1 and comprise the allelic entities @entity9 ( @entity9 ), @entity9 ( @entity9 ) and @entity13 ( @entity13 ). In all three entities, the heart is affected to various degrees, depending on the stage of the disease and the type of the mutation (cardiac involvement, CI). The pathoanatomic evidence of CI in dystrophinopathies is the replacement of myocardium by connective tissue or fat. In @entity9 / @entity9 , the left ventricular posterobasal and lateral walls are most extensively affected, sparing the right ventricle and the atrium. Degree and dynamics of CI vary among the three entities. In @entity9 / @entity9 , CI usually remains subclinical in the early stages of the disease. Typical initial manifestations of CI in @entity9 / @entity9 are @entity12 , tall R1 in V1, prominent Q in I, aVL, V6 or in II, III, and aVF, @entity8 and possibly @entity11 . Initially, echocardiography is normal or shows regional wall motion abnormalities in areas of @entity1 . With spreading of @entity1 , @entity7 and @entity5 additionally occur. In the final stages of the disease, systolic function may lead to @entity4 and @entity6 . Subclinical or clinical CI is present in about 90% of the @entity9 / @entity9 @entity0 but is the cause of @entity2 in only 20% of the @entity9 and 50% of the @entity9 @entity0 . @entity13 is a rapidly progressive, almost exclusively @entity3 , starting in teenage males as @entity4 due to dilative @entity3 ( @entity3 ), leading to @entity2 from intractable @entity4 within 1-2 years after diagnosis. Therapy of @entity5 and @entity3 in all three disorders follows the established cardiological recommendations. Due to its protective effect, ACE inhibitors are recommended already at the early stages of the disease. Beta-blockers may be an additional option if indicated.

title: The heart in XXXX dystrophinopathies.

answer: @entity0


abstract: In cadaveric liver transplantation, the Milan criteria have been accepted as the selection criteria for @entity3 ( @entity3 ) @entity0 in considering organ allocation. However, the situation is different in living-donor liver transplantation (LDLT), in which the donor has a strong preference for altruism. The authors describe herein their experience with LDLT for @entity3 @entity0 using their @entity0 selection criteria. From February 1999 to March 2002, right lobe LDLT was performed in 56 @entity0 with @entity3 . The authors' exclusion criteria included only those with extrahepatic @entity1 or vascular invasion detected during preoperative evaluation. Thirty @entity0 (54%) were in @entity2 , node, @entity1 stage IVa and 25 @entity0 (45%) did not meet the Milan criteria at the time of LDLT. The follow-up period was 1 to 39 months (median, 11 months). The overall survival rates at 1 and 3 years were 73% and 55%, respectively, and the latter was significantly lower than that of adult right lobe LDLT without @entity3 (71% at 3 years). Fourteen @entity0 died because of @entity4 without @entity2 recurrence. Thirty-six @entity0 survived without recurrence and six @entity0 had recurrence. Among the six @entity0 with recurrence, four had survived for 11 to 36 months after LDLT. In the analysis of @entity0 who survived longer than 3 months after transplantation, 19 of 20 within the Milan criteria survived without recurrence. However, 15 of 20 @entity0 beyond the criteria also survived without recurrence for 3 to 33 months (median, 12 months) and three of five @entity0 with recurrence were alive for 11 to 36 months (median, 20 months). Histopathologic grading and microscopic portal venous invasion had significant negative impact on @entity2 recurrence. LDLT was an effective treatment for uncontrollable @entity3 . Because many @entity0 who did not meet the Milan criteria survived without @entity2 recurrence after transplantation, different @entity0 selection criteria are necessary in LDLT to save those with advanced @entity3 .

title: Living-donor liver transplantation for XXXX .

answer: @entity3


abstract: PURPOSE OF REVIEW: This review analyses the recently published literature focusing on nutritional assessment in intensive care unit @entity0 . The metabolic response to nutritional intervention is difficult to evaluate in critically ill @entity0 whose body weight is influenced largely by massive fluid administration or losses. Visceral protein plasma levels have been proposed for this purpose, because they reflect hepatic synthesis in response to nutrient supply. However, in acute inflammatory states, liver activity is converted to the synthesis of acute-phase response proteins, resulting in a dramatic drop in visceral proteins, despite nutritional support. RECENT FINDINGS: The data regarding visceral protein levels were examined in relation to nutritional supplementation, and compared with other nutritional parameters and clinical outcomes. @entity3 and @entity1 -binding protein levels seem to be the most sensitive to nutritional intervention. They are also the earliest to rise at the decrease of acute-phase protein levels, therefore representing a good index of the reversing reprioritization of hepatic protein synthesis. An inconsistent relationship was found between visceral protein plasma levels and clinical outcome in intensive care unit @entity0 , probably because of the difficulty in demonstrating clearly a beneficial effect of nutritional supplementation in highly catabolic conditions. SUMMARY: In the acute stage of @entity2 , the bi-weekly measurement of @entity3 together with acute-phase response protein plasma levels seems to be a 'window' on the metabolic condition (anabolism versus catabolism). However, only in the presence of stable inflammatory parameters do @entity3 levels reflect the adequacy of nutritional coverage.

title: The role of visceral proteins in the nutritional assessment of intensive care unit XXXX .

answer: @entity0


abstract: PURPOSE: Spontaneous dissection of the carotid and vertebral arteries represents a rare pathology. Its pathogenesis, probably multi-factorial, can be related to neck @entity3 and to a genetic basis, extensively demonstrated in the cases of association with type IV @entity10 , @entity9 , @entity6 , @entity12 and @entity11 . Onset symptoms include neck, @entity4 and @entity1 . @entity2 has been also described. The aim of this study was to evaluate MR angiography and MR findings in a population of @entity0 with @entity8 . MATERIALS AND METHODS: We reviewed the MR angiography and MR exams of 15 @entity0 (10 males, 5 females, average age 42.0, age range 30-55) with carotid and/or @entity8 ; the serial MR follow-up studies were also examined. RESULTS: Twelve internal carotid arteries (ICA) showed the presence of an @entity5 ; three of these showed complete occlusion. In two @entity0 both ICA were involved. Six vertebral arteries (VA) showed @entity5 (only one @entity0 suffered from both CI and VA dissection); in one case there was also a @entity7 of the VA. Follow-up studies showed vessel lumen re-opening in 5/11 ICA (one @entity0 underwent vascular stent positioning) and in 3/6 VA. CONCLUSIONS: The present study confirms the usefulness of MR angiography and MR in the diagnosis and follow-up of @entity0 with @entity8 .

title: Carotid and XXXX : Magnetic Resonance findings in 15 cases.

answer: @entity8


abstract: BACKGROUND: Prompt recognition of invasive @entity2 ( @entity4 ) after heart transplantation is essential for achieving a successful outcome. However, the significance of the isolation of from respiratory specimens in heart transplant recipients is not established. METHODS: From 1990 to 1999, we analyzed first respiratory specimens with spp. growth from heart transplant @entity0 in our institution. All specimens were cultured in both fungal and conventional media. Diagnosis of proven and probable @entity4 or colonization was made according to criteria of the Mycoses Study Group. RESULTS: During the 10-year study period, spp. was recovered from 30 episodes from 27 heart transplant recipients (incidence: 10.5%). Three episodes were classified as indeterminate and were included in the analysis in a double way, first considering them as true positives and afterward as true negatives, so ranges were obtained. After applying diagnostic criteria, 18 of 30 episodes were proven or probable @entity4 , and 9 episodes were colonizations. Accordingly, 7 to 8% of heart transplant recipients suffered an @entity4 , and the overall positive predictive value ( @entity3 ) was 60% to 70%. When analyzed by species, the @entity3 of recovering was 78% to 91%, whereas it was 0% for other species. The @entity3 increased to 88% to 100% when was recovered from a respiratory specimen other than sputum and decreased to 50% to 67% when it was recovered from sputum. The sensitivities of fungal and conventional media for the recovery of spp. were 95% to 100% and 33% to 38%, respectively. CONCLUSION: The isolation of from the respiratory tract of a heart transplant recipient is highly predictive of @entity1 .

title: The isolation of Aspergillus fumigatus from respiratory tract specimens in heart transplant recipients is highly predictive of XXXX .

answer: @entity1


abstract: OBJECTIVES: To test the validity of the comparative audit tool of POSSUM (Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity) against a cohort of 92 consecutive laryngectomies at a major tertiary referral centre for @entity1 . The major outcome measurements were 30-day mortality rates, formation of a pharyngo-cutaneous @entity2 , and length of hospital stay. METHODS: By means of a prospective and retrospective case note analysis. RESULTS: No significant difference between the mean POSSUM morbidity scores of those @entity0 who did, or did not develop a @entity2 , was found (p=0.535, 95% C.I. -4.36 to 8.33). No significant correlation was observed between POSSUM predicted morbidity and bed occupancy [r=0.137 (95% C.I. -0.070 to 0.334)]. The Portsmouth POSSUM equation for mortality however did accurately predict the mortality rate (observed to expected ratio of 1.05). CONCLUSION: The authors propose that whilst there are many similar factors linked to mortality between cohorts of general surgical and head and neck @entity0 , there are several highly specific risk factors in open surgery of the upper aero-digestive tract in the head and neck which are linked with wound breakdown and morbidity which are omitted from the POSSUM scoring system. The authors warn against the use of this comparative audit tool in its current state for such surgical procedures and recommend the creation of a specific POSSUM for @entity1 surgery.

title: Is POSSUM predictive of morbidity and mortality in laryngectomy XXXX ?

answer: @entity0


abstract: BACKGROUND: Damage to the airway epithelium is one prominent feature of the damage seen in chronic @entity4 . Cortico- @entity2 induce apoptosis in inflammatory cells, which in part explains their ability to suppress @entity1 . However, corticosteroid therapy does not necessarily reverse the epithelial damage seen in asthmatic airways. OBJECTIVE: We hypothesized that @entity3 might induce airway epithelial cell apoptosis as one potential explanation for this persistent damage. METHODS: BALB/c @entity0 were treated with 1 mg/kg @entity5 by means of intraperitoneal injection for 3 days to 4 weeks. Additional @entity0 were sensitized and challenged with @entity7 and then followed for 14 days with or without @entity5 treatment starting on day 4 after challenge. Apoptosis was measured by using terminal deoxynucleotidyl transferase-mediated @entity6 nick end labeling and immunohistochemistry for the @entity9 cleavage product of @entity8 polymerase. Shed epithelial cells were counted in bronchoalveolar lavage fluid. RESULTS: In a time-dependent manner @entity5 treatment increased epithelial cell apoptosis and shedding into the airway lumen. This was not associated with any change in the abundance of the apoptotic regulator @entity10 . In animals sensitized and challenged with @entity7 , treatment with 1 mg/kg @entity5 starting 4 days after challenge reversed the inflammatory changes but did not reverse either epithelial cell shedding or apoptosis seen after allergen challenge. CONCLUSION: Corticosteroids might induce apoptotic cell death of airway epithelium in vivo and fail to mitigate epithelial cell shedding and apoptosis elicited by means of allergen challenge. This raises the possibility that at least one of the major components of chronic airway damage in @entity4 , epithelial shedding, might in part result from a major therapy used for disease control.

title: Corticosteroid-induced apoptosis in @entity0 airway epithelium: effect in normal airways and after allergen-induced XXXX .

answer: @entity1


abstract: BACKGROUND: Damage to the airway epithelium is one prominent feature of the damage seen in chronic @entity4 . Cortico- @entity2 induce apoptosis in inflammatory cells, which in part explains their ability to suppress @entity1 . However, corticosteroid therapy does not necessarily reverse the epithelial damage seen in asthmatic airways. OBJECTIVE: We hypothesized that @entity3 might induce airway epithelial cell apoptosis as one potential explanation for this persistent damage. METHODS: BALB/c @entity0 were treated with 1 mg/kg @entity5 by means of intraperitoneal injection for 3 days to 4 weeks. Additional @entity0 were sensitized and challenged with @entity7 and then followed for 14 days with or without @entity5 treatment starting on day 4 after challenge. Apoptosis was measured by using terminal deoxynucleotidyl transferase-mediated @entity6 nick end labeling and immunohistochemistry for the @entity9 cleavage product of @entity8 polymerase. Shed epithelial cells were counted in bronchoalveolar lavage fluid. RESULTS: In a time-dependent manner @entity5 treatment increased epithelial cell apoptosis and shedding into the airway lumen. This was not associated with any change in the abundance of the apoptotic regulator @entity10 . In animals sensitized and challenged with @entity7 , treatment with 1 mg/kg @entity5 starting 4 days after challenge reversed the inflammatory changes but did not reverse either epithelial cell shedding or apoptosis seen after allergen challenge. CONCLUSION: Corticosteroids might induce apoptotic cell death of airway epithelium in vivo and fail to mitigate epithelial cell shedding and apoptosis elicited by means of allergen challenge. This raises the possibility that at least one of the major components of chronic airway damage in @entity4 , epithelial shedding, might in part result from a major therapy used for disease control.

title: Corticosteroid-induced apoptosis in XXXX airway epithelium: effect in normal airways and after allergen-induced @entity1 .

answer: @entity0


abstract: @entity2 ( @entity2 ) are the most abundant heat stress-induced proteins in plants. In @entity1 , there are at least seven members of class-I @entity2 . A 1.6-kb DNA fragment was isolated from the EcoRI-digested @entity1 genomic library probed with the cDNA pTS1 encoding a 16.9-kDa class-I @entity2 . This fragment was composed of 365-bp tandem direct repeats (DRs) and 441-bp near perfect long terminal inverted repeats (LTIRs). The DRs contain 123-bp regions with 99% @entity0 identity to the 5' coding region of the Oshsp16.9B gene. Two putative pseudogenes were deduced from the DRs. Using the LTIR as a specific probe, Southern-blotting analysis showed that there was a single copy of this 1.6-kb DNA fragment in the @entity1 genome. By genomic walking, we located this fragment in proximity 5'-upstream of the Oshsp16.9B gene that was mapped on chromosome 1 with other two class-I @entity2 genes, Oshsp16.9A and Oshsp16.9C. By comparative analysis of the @entity0 sequences of class-I @entity2 genes clustered on chromosome 1 between Tainung No. 67 and Nipponbare cultivars, we confirmed our mapping results of these genes and only the promoter region of Oshsp16.9B was different. However, we found that the expression profile of Oshsp16.9B upon different heat stresses in Nipponbare was not significantly different relative to that in Tainung No. 67.

title: Characterization of a unique genomic clone located 5' upstream of the Oshsp16.9B gene on chromosome 1 in XXXX ( @entity1 . cv Tainung No. 67).

answer: @entity1


abstract: @entity2 ( @entity2 ) are the most abundant heat stress-induced proteins in plants. In @entity1 , there are at least seven members of class-I @entity2 . A 1.6-kb DNA fragment was isolated from the EcoRI-digested @entity1 genomic library probed with the cDNA pTS1 encoding a 16.9-kDa class-I @entity2 . This fragment was composed of 365-bp tandem direct repeats (DRs) and 441-bp near perfect long terminal inverted repeats (LTIRs). The DRs contain 123-bp regions with 99% @entity0 identity to the 5' coding region of the Oshsp16.9B gene. Two putative pseudogenes were deduced from the DRs. Using the LTIR as a specific probe, Southern-blotting analysis showed that there was a single copy of this 1.6-kb DNA fragment in the @entity1 genome. By genomic walking, we located this fragment in proximity 5'-upstream of the Oshsp16.9B gene that was mapped on chromosome 1 with other two class-I @entity2 genes, Oshsp16.9A and Oshsp16.9C. By comparative analysis of the @entity0 sequences of class-I @entity2 genes clustered on chromosome 1 between Tainung No. 67 and Nipponbare cultivars, we confirmed our mapping results of these genes and only the promoter region of Oshsp16.9B was different. However, we found that the expression profile of Oshsp16.9B upon different heat stresses in Nipponbare was not significantly different relative to that in Tainung No. 67.

title: Characterization of a unique genomic clone located 5' upstream of the Oshsp16.9B gene on chromosome 1 in @entity1 ( XXXX . cv Tainung No. 67).

answer: @entity1


abstract: BACKGROUND: The application of a single allergen specific IgE (sIgE) cut point, such as 0.35 kU/L, to determine sensitization for all allergens may be suboptimal. OBJECTIVES: To analyze self-reported symptoms suggestive of @entity1 and cat @entity2 in relation to the test performance characteristics of low level, but reliably detectable, sIgE and to compare these cut points to the traditional 0.35-kU/L cut point. METHODS: Interviews and blood samples were collected among 564 young adult @entity0 of a general risk birth cohort. Data collected from the @entity0 ' parents were analyzed as validation populations. A history of symptoms consistent with @entity2 on exposure to pets was obtained by standardized questionnaire. Allergen sIgE levels for @entity1 and cat were evaluated with Pharmacia @entity3 . Receiver operating characteristic curves were constructed and the performance characteristics of the traditional sIgE cut point of 0.35 kU/L were compared with cut points as low as 0.1 kU/L. RESULTS: Using the Youden J criteria, based on the highest sum of sensitivity and specificity for a diagnostic test, cut points of 0.12 kU/L for cat and 0.2 kU/L for @entity1 were identified as performing optimally among the @entity0 population. In 2 validation populations, consisting of the @entity0 ' mothers and fathers, the performance of these alternative cut points were superior or similar to the traditional 0.35-kU/L sIgE level. CONCLUSIONS: Accurately measured sIgE at levels approaching the lower limit of detection of current assays may be useful in confirming sensitization. Optimal clinical application of these tests will continue to require careful integration of the result and the strength of the @entity0 's history.

title: Analysis of allergen specific IgE cut points to cat and XXXX in the Childhood Allergy Study.

answer: @entity1


abstract: OBJECTIVES: To report 3 cases @entity13 ( @entity13 ) that developed in @entity0 suffering from @entity7 ( @entity7 ) and to review previously reported cases. METHODS: We describe 3 @entity0 diagnosed with @entity7 who developed severe @entity13 that presented as @entity12 . A retrospective review of the literature was performed using the PubMed database. RESULTS: The first @entity0 presented with rapidly progressive @entity4 and then with 2 episodes of @entity6 . She was partially refractory to treatment with @entity5 and @entity8 but responded promptly to treatment with rituximab. The second @entity0 suffered from 2 episodes of @entity6 ; the first responded to intravenous @entity5 , but the second was fatal despite aggressive immune suppression with @entity5 and @entity8 . The third @entity0 presented with a clinical picture compatible with @entity1 ( @entity1 ) but was later diagnosed with crescentic GN and subsequently died from probable @entity6 . Thirty-seven cases of @entity13 in @entity7 @entity0 have been described in the English literature. Clinical manifestations include rapidly progressive GN, @entity6 , @entity2 , and @entity10 . In contrast to @entity1 that usually develops early in the course of @entity7 , ANCA-associated GN in @entity7 @entity0 occurred later, after several years of illness. @entity3 , @entity11 , and @entity9 that are the hallmark of @entity1 were observed only in a minority of @entity13 cases. Almost all cases of @entity13 in @entity7 were positive for MPO-ANCA. CONCLUSIONS: @entity13 in the setting of @entity7 is a diagnostic challenge. Differential diagnosis from @entity1 is crucial as treatment approach for these conditions completely differs. High doses of @entity5 and immune suppression are advocated in severe @entity13 . In resistant cases, treatment with rituximab may be considered.

title: Anti-neutrophil antibody associated vasculitis in XXXX .

answer: @entity7


abstract: OBJECTIVE: To report the magnetic resonance (MR) imaging findings of enlarged veins in the spinoglenoid notch as a cause of @entity4 . DESIGN AND @entity0 : Six @entity0 presented to MR imaging for evaluation of chronic @entity1 . Clinical information and MR imaging studies were reviewed. The spinoglenoid notch vascular structures were compared with measurements made in 10 age-matched controls. RESULTS: Spinoglenoid notch vascular structures measured in 10 asymptomatic age-matched control @entity0 ranged from 1 to 4 mm in diameter with an average of 2.2 mm. The six study @entity0 had vascular structures that ranged from 6 to 10 mm in diameter with an average of 8.4 mm. @entity2 and @entity3 of the infraspinatus muscle was noted as an associated finding at MR imaging in all six @entity0 . Surgery was performed in three of the six @entity0 , at which time a venous varix was identified in the spinoglenoid notch in all three @entity0 . CONCLUSION: We describe distended veins in the spinoglenoid notch. These may be readily apparent at MR imaging and should be distinguished from @entity4 in the absence of labral tears, especially if percutaneous aspiration of a ganglion cyst is entertained.

title: Enlarged spinoglenoid notch veins causing XXXX .

answer: @entity4


abstract: The impact of @entity2 ( @entity7 ) and @entity8 in pediatrics has markedly increased during the last few decades. Critical periods in the development of the central nervous system need special attention in @entity0 with these disorders. Early diagnosis and treatment are important in order to prevent @entity5 and serious handicaps in some of these @entity0 . Certain @entity0 with @entity2 lack early clinical symptoms or have so non-specific signs that permanent @entity1 are present when the @entity0 are finally diagnosed. One way to identify these @entity0 is by means of mass screening. A blood sample is then collected from every newborn @entity0 and analyzed for abnormal levels of metabolites or hormones. It is possible to detect at least thirty different disorders in this way. In most European countries screening programmes involve @entity4 ( @entity4 ) and @entity9 . The prognosis for these @entity0 has improved dramatically after the introduction of screening. The Swedish neonatal metabolic screening programme was started in 1965 by screening for @entity4 . Subsequently, screening for @entity6 and @entity9 was added. The result of the screening programme 1965-1985 is as follows: (table; see text) The main benefit of early detection and treatment of @entity0 with @entity4 , @entity9 and @entity6 is the prevention of @entity5 and other handicaps. Recently nationwide pilot screening for @entity3 ( @entity10 ) was started.

title: Neonatal screening for XXXX .

answer: @entity2


abstract: BACKGROUND AND AIMS: The Barcelona Clinic @entity2 (BCLC) staging system is the algorithm most widely used to manage @entity0 with @entity3 ( @entity3 ). We aimed to investigate the extent to which the BCLC recommendations effectively guide clinical practice and assess the reasons for any deviation from the recommendations. MATERIAL AND METHODS: The first-line treatments assigned to @entity0 included in the prospective Bern @entity3 cohort were analyzed. RESULTS: Among 223 @entity0 included in the cohort, 116 were not treated according to the BCLC algorithm. Eighty percent of the @entity0 in BCLC stage 0 (very early @entity3 ) and 60% of the @entity0 in BCLC stage A (early @entity3 ) received recommended curative treatment. Only 29% of the BCLC stage B @entity0 (intermediate @entity3 ) and 33% of the BCLC stage C @entity0 (advanced @entity3 ) were treated according to the algorithm. Eighty-nine percent of the BCLC stage D @entity0 (terminal @entity3 ) were treated with best supportive care, as recommended. In 98 @entity0 (44%) the performance status was disregarded in the stage assignment. CONCLUSION: The management of @entity3 in clinical practice frequently deviates from the BCLC recommendations. Most of the curative therapy options, which have well-defined selection criteria, were allocated according to the recommendations, while the majority of the palliative therapy options were assigned to @entity0 with @entity1 stages not aligned with the recommendations. The only parameter which is subjective in the algorithm, the performance status, is also the least respected.

title: Treatment allocation in XXXX : Assessment of the BCLC algorithm.

answer: @entity3


abstract: PURPOSE: To evaluate the effectiveness of acellular @entity2 pericardium grafts (Normal GEN  ) used as scaffolds for conjunctival reconstruction. METHOD: The acellular @entity2 pericardium graft and the amnion graft were implanted into the bulbar conjunctival defects of adult @entity0 . Conjunctival samples of implanted materials and @entity1 controls were observed at day 3, 7, 14, 21, 28, and 56 postoperatively. Histological examination was observed at day 14, 28, and 56 of surgery, including @entity3 - @entity4 staining, periodic acid-Schiff staining, and Masson's trichrome staining, while immunofluorescent microscopy was observed at 14  days and 28  days after surgery. Results were compared among the Normal GEN  , amnion, and @entity1 controls. RESULTS: All three groups showed complete conjunctival reconstruction. Wounds that were not grafted closed by formation of conjunctival scar characterized by a linear array of densely packed collagen fibers in Tenon's capsule. Subepithelial tissue in the grafted groups comprised a loosely organized network of randomly oriented collagen that resembled that of the normal bulbar conjunctiva. However, there was a dense layer of aligned collagen between the conjunctival Tenon's capsule and the sclera in the NormalGEN   group, about 250   m in thickness. CONCLUSIONS: Implantation of the NormalGEN   graft promoted the formation of conjunctiva as a kind of scaffold both in structure and in function. It had more advantageous mechanical properties than the amnion, strong and elastic, during the period of conjunctival reconstruction.

title: Conjunctival structural and functional reconstruction using acellular XXXX pericardium graft (Normal GEN  ) in @entity0 .

answer: @entity2


abstract: PURPOSE: To evaluate the effectiveness of acellular @entity2 pericardium grafts (Normal GEN  ) used as scaffolds for conjunctival reconstruction. METHOD: The acellular @entity2 pericardium graft and the amnion graft were implanted into the bulbar conjunctival defects of adult @entity0 . Conjunctival samples of implanted materials and @entity1 controls were observed at day 3, 7, 14, 21, 28, and 56 postoperatively. Histological examination was observed at day 14, 28, and 56 of surgery, including @entity3 - @entity4 staining, periodic acid-Schiff staining, and Masson's trichrome staining, while immunofluorescent microscopy was observed at 14  days and 28  days after surgery. Results were compared among the Normal GEN  , amnion, and @entity1 controls. RESULTS: All three groups showed complete conjunctival reconstruction. Wounds that were not grafted closed by formation of conjunctival scar characterized by a linear array of densely packed collagen fibers in Tenon's capsule. Subepithelial tissue in the grafted groups comprised a loosely organized network of randomly oriented collagen that resembled that of the normal bulbar conjunctiva. However, there was a dense layer of aligned collagen between the conjunctival Tenon's capsule and the sclera in the NormalGEN   group, about 250   m in thickness. CONCLUSIONS: Implantation of the NormalGEN   graft promoted the formation of conjunctiva as a kind of scaffold both in structure and in function. It had more advantageous mechanical properties than the amnion, strong and elastic, during the period of conjunctival reconstruction.

title: Conjunctival structural and functional reconstruction using acellular @entity2 pericardium graft (Normal GEN  ) in XXXX .

answer: @entity0


abstract: OBJECTIVE: To determine if the characteristics of @entity0 with @entity2 changed as minimally invasive modalities for diagnosis and surgical treatment were integrated to our clinical practice. MATERIALS AND METHODS: The pathologic reports of all @entity0 diagnosed with @entity2 in 1990 (220 @entity0 ) and 1996 (386 @entity0 ) were reviewed. The respective medical records were reviewed for anthropomorphic factors, bleeding pattern, diagnosis, and modality of surgical removal. Comparisons of dichotomous data and analysis of nominal variables with two or more categories were carried out with the chi(2) test. RESULTS: Differences in @entity0 characteristics or pattern of bleeding were minimal. In both groups, @entity2 were more frequent in @entity0 with @entity1 , reaching almost 80%. Diagnostic and therapeutic modalities were significantly different in 1990 vs. 1996. Diagnosis by ultrasound increased fivefold (3.6 vs. 16.8%) and operative hysteroscopy increased threefold (6.4 vs. 19.7). The frequency of incidental diagnosis of @entity2 at the time of hysterectomy decreased significantly. The most frequent modality of surgery done in 1990 was dilatation and curettage (44.6%), followed in frequency by endometrial biopsy and abdominal hysterectomy. In contrast, the most frequent modality in 1996 was hysteroscopic resection (36.8%), followed by dilatation and curettage (12.8%). CONCLUSIONS: The introduction of minimally invasive methods of diagnosis and treatment of @entity2 has not changed the overall @entity0 population with this lesion.

title: Does the introduction of new technology change population demographics? Minimally invasive technologies and XXXX .

answer: @entity2


abstract: @entity4 is a slowly developing but very common @entity1 in males that may be amenable to preventive strategies that are not toxic. Chinese red @entity6 @entity7 (RYR), a food herb made by fermenting Monascus purpureus Went @entity6 on white @entity7 , contains a mixture of eight different monacolins that inhibit cholesterogenesis in addition to red pigments with antioxidant properties. Monacolin K is identical to lovastatin (LV), but LV unlike RYR can be used in individuals intolerant to statins due to @entity9 . Both LV and RYR inhibit de novo cholesterogenesis, which is critical to the growth of @entity1 cells. Long-term use of statin drugs has been associated with a reduced risk of @entity4 . We have previously shown that RYR inhibited @entity5 -dependent and @entity5 receptor-overexpressing @entity5 -independent @entity4 cell proliferation in vitro. This study was designed to determine whether RYR and @entity4 growth in @entity8 @entity2 . RYR significantly reduced @entity1 volumes of @entity5 -dependent and @entity5 -independent prostate xenograft @entity1 compared with animals receiving vehicle alone (P < 0.05). Inhibition by RYR was greater than that observed with LV at the dose found in RYR, showing that other compounds in RYR contributed to the antiproliferative effect. There was a significant correlation of @entity1 volume to serum @entity3 (P < 0.001). RYR decreased gene expression of @entity5 synthesizing enzymes (HSD3B2, AKR1C3, and SRD5A1) in both type of @entity1 (P < 0.05). Clinical studies of RYR for @entity4 prevention in the increasing population of @entity0 undergoing active surveillance should be considered.

title: Chinese red XXXX @entity7 @entity4 growth in @entity8 @entity2 .

answer: @entity6


abstract: @entity4 is a slowly developing but very common @entity1 in males that may be amenable to preventive strategies that are not toxic. Chinese red @entity6 @entity7 (RYR), a food herb made by fermenting Monascus purpureus Went @entity6 on white @entity7 , contains a mixture of eight different monacolins that inhibit cholesterogenesis in addition to red pigments with antioxidant properties. Monacolin K is identical to lovastatin (LV), but LV unlike RYR can be used in individuals intolerant to statins due to @entity9 . Both LV and RYR inhibit de novo cholesterogenesis, which is critical to the growth of @entity1 cells. Long-term use of statin drugs has been associated with a reduced risk of @entity4 . We have previously shown that RYR inhibited @entity5 -dependent and @entity5 receptor-overexpressing @entity5 -independent @entity4 cell proliferation in vitro. This study was designed to determine whether RYR and @entity4 growth in @entity8 @entity2 . RYR significantly reduced @entity1 volumes of @entity5 -dependent and @entity5 -independent prostate xenograft @entity1 compared with animals receiving vehicle alone (P < 0.05). Inhibition by RYR was greater than that observed with LV at the dose found in RYR, showing that other compounds in RYR contributed to the antiproliferative effect. There was a significant correlation of @entity1 volume to serum @entity3 (P < 0.001). RYR decreased gene expression of @entity5 synthesizing enzymes (HSD3B2, AKR1C3, and SRD5A1) in both type of @entity1 (P < 0.05). Clinical studies of RYR for @entity4 prevention in the increasing population of @entity0 undergoing active surveillance should be considered.

title: Chinese red @entity6 XXXX @entity4 growth in @entity8 @entity2 .

answer: @entity7


abstract: @entity4 is a slowly developing but very common @entity1 in males that may be amenable to preventive strategies that are not toxic. Chinese red @entity6 @entity7 (RYR), a food herb made by fermenting Monascus purpureus Went @entity6 on white @entity7 , contains a mixture of eight different monacolins that inhibit cholesterogenesis in addition to red pigments with antioxidant properties. Monacolin K is identical to lovastatin (LV), but LV unlike RYR can be used in individuals intolerant to statins due to @entity9 . Both LV and RYR inhibit de novo cholesterogenesis, which is critical to the growth of @entity1 cells. Long-term use of statin drugs has been associated with a reduced risk of @entity4 . We have previously shown that RYR inhibited @entity5 -dependent and @entity5 receptor-overexpressing @entity5 -independent @entity4 cell proliferation in vitro. This study was designed to determine whether RYR and @entity4 growth in @entity8 @entity2 . RYR significantly reduced @entity1 volumes of @entity5 -dependent and @entity5 -independent prostate xenograft @entity1 compared with animals receiving vehicle alone (P < 0.05). Inhibition by RYR was greater than that observed with LV at the dose found in RYR, showing that other compounds in RYR contributed to the antiproliferative effect. There was a significant correlation of @entity1 volume to serum @entity3 (P < 0.001). RYR decreased gene expression of @entity5 synthesizing enzymes (HSD3B2, AKR1C3, and SRD5A1) in both type of @entity1 (P < 0.05). Clinical studies of RYR for @entity4 prevention in the increasing population of @entity0 undergoing active surveillance should be considered.

title: Chinese red @entity6 @entity7 @entity4 growth in @entity8 XXXX .

answer: @entity2


abstract: @entity4 is a slowly developing but very common @entity1 in males that may be amenable to preventive strategies that are not toxic. Chinese red @entity6 @entity7 (RYR), a food herb made by fermenting Monascus purpureus Went @entity6 on white @entity7 , contains a mixture of eight different monacolins that inhibit cholesterogenesis in addition to red pigments with antioxidant properties. Monacolin K is identical to lovastatin (LV), but LV unlike RYR can be used in individuals intolerant to statins due to @entity9 . Both LV and RYR inhibit de novo cholesterogenesis, which is critical to the growth of @entity1 cells. Long-term use of statin drugs has been associated with a reduced risk of @entity4 . We have previously shown that RYR inhibited @entity5 -dependent and @entity5 receptor-overexpressing @entity5 -independent @entity4 cell proliferation in vitro. This study was designed to determine whether RYR and @entity4 growth in @entity8 @entity2 . RYR significantly reduced @entity1 volumes of @entity5 -dependent and @entity5 -independent prostate xenograft @entity1 compared with animals receiving vehicle alone (P < 0.05). Inhibition by RYR was greater than that observed with LV at the dose found in RYR, showing that other compounds in RYR contributed to the antiproliferative effect. There was a significant correlation of @entity1 volume to serum @entity3 (P < 0.001). RYR decreased gene expression of @entity5 synthesizing enzymes (HSD3B2, AKR1C3, and SRD5A1) in both type of @entity1 (P < 0.05). Clinical studies of RYR for @entity4 prevention in the increasing population of @entity0 undergoing active surveillance should be considered.

title: Chinese red @entity6 @entity7 XXXX growth in @entity8 @entity2 .

answer: @entity4


abstract: @entity4 is a slowly developing but very common @entity1 in males that may be amenable to preventive strategies that are not toxic. Chinese red @entity6 @entity7 (RYR), a food herb made by fermenting Monascus purpureus Went @entity6 on white @entity7 , contains a mixture of eight different monacolins that inhibit cholesterogenesis in addition to red pigments with antioxidant properties. Monacolin K is identical to lovastatin (LV), but LV unlike RYR can be used in individuals intolerant to statins due to @entity9 . Both LV and RYR inhibit de novo cholesterogenesis, which is critical to the growth of @entity1 cells. Long-term use of statin drugs has been associated with a reduced risk of @entity4 . We have previously shown that RYR inhibited @entity5 -dependent and @entity5 receptor-overexpressing @entity5 -independent @entity4 cell proliferation in vitro. This study was designed to determine whether RYR and @entity4 growth in @entity8 @entity2 . RYR significantly reduced @entity1 volumes of @entity5 -dependent and @entity5 -independent prostate xenograft @entity1 compared with animals receiving vehicle alone (P < 0.05). Inhibition by RYR was greater than that observed with LV at the dose found in RYR, showing that other compounds in RYR contributed to the antiproliferative effect. There was a significant correlation of @entity1 volume to serum @entity3 (P < 0.001). RYR decreased gene expression of @entity5 synthesizing enzymes (HSD3B2, AKR1C3, and SRD5A1) in both type of @entity1 (P < 0.05). Clinical studies of RYR for @entity4 prevention in the increasing population of @entity0 undergoing active surveillance should be considered.

title: Chinese red @entity6 @entity7 @entity4 growth in XXXX @entity2 .

answer: @entity8


abstract: Per-partum @entity2 is a frequent situation facing the pediatrician in the maternity ward. The question is to decide which @entity0 require care in a specialized unit. If transfer is decided, the @entity0 must be referred to an appropriate pediatric unit (intensive care or neonatal unit). Cases of severe @entity2 are exceptional. Intermediary situations are however much more frequent and raise difficult evaluation problems due to the lack of any specific test. The pediatrician must rely on a combination of elements from the clinical presentation, the medical history, the clinical course, and laboratory tests. Different elements suggest a prudent approach with referral to a pediatric unit. These elements include: imperfect clinical recovery (5-min Agpar <7), major intensive care at delivery (intubation, ventilation, vasoactive agents), @entity4 or first hour blood tests (cord pH<7, base deficit 12, cord or blood @entity3 9 mmol/l). Obstetrical circumstances which led to per-partum @entity2 must be well identified because those interrupting placental flow ( @entity7 , @entity9 ) suggest prudence is necessary even if the @entity0 appears to have recovered well. All @entity6 ( @entity8 , prematurity, @entity5 ) increase the risk of rapid decompensation and may argue for hospitalization. Likewise, if even minimal signs of neurological, respiratory or @entity1 are present from birth to two hours, surveillance in a specialized unit is required, the level depending on local facilities. Certain situations nevertheless always require referral to a pediatric intensive care unit: use of vasoactive drugs, respiratory distress, abnormal neurological exam, poor recovery (5-min Agpar <4).Finally, it must be remembered that per-partum @entity2 is rarely predictable and can occur any at any time of day or night. The pediatrician must also train other delivery room personnel, including the midwives, in intensive care techniques.

title: [Orientation after peripartum asphyxia in the maternity ward: which XXXX should be transferred to pediatric care units?].

answer: @entity0


abstract: This review considers the esophagectomy techniques in the treatment of @entity4 and provides the guidelines for optimizing the @entity0 ' chances at cure, minimizing the risk of mediastinal enteric leak (which carries a mortality rate as high as 50%) and minimizing associated @entity3 . The 4 most commonly used routes for resection and replacement include a transhiatal, transthoracic (Ivor-Lewis), tri-incisional (right chest then simultaneous abdominal and left neck), and left chest (distal @entity1 ). Each of these techniques will be described as will the use of colon and jejunum for esophageal replacement. The healthy stomach is the preferred conduit for esophageal replacement. The stomach is well vascularized, easily reaches to the neck, and requires only a single @entity2 for re-establishing intestinal continuity. When the stomach is not available (usually because of prior surgery or disease) the choice of conduits include colon and jejunum. With respect to minimally invasive esophagectomy for @entity4 , several groups have significant experience with this and report excellent results. This is an evolving technique but holds much promise for improving the quality of life of @entity0 with @entity1 without compromising their survival. In locally advanced middle third @entity1 , thoracotomy and dissection under direct vision's desirable and improves the safety of the operation. The same may apply to @entity1 receiving neoadjuvant therapy. For @entity1 of the distal esophagus, transhiatal, tri-incisional, and Ivor-Lewis resection are probably equally as safe, and appear to result in equivalent long-term survival. An intrathoracic @entity5 is disastrous, carrying a mortality rate of up to 50%. Any surgeon who performs esophagectomy with an intrathoracic @entity2 must do so with a low incidence of leakage, certainly under 5%. Consideration should be given to a cervical placement if there are factors increasing the risk such as the use of induction therapy.

title: Esophagectomy for XXXX .

answer: @entity4


abstract: BACKGROUND: @entity7 is an independent predictor of future @entity5 . MATERIAL/METHODS: We evaluated the relationship between @entity6 ( @entity6 ) in brachial artery and coronary risk factors in 93 @entity0 (70 males, mean age: 62    8 years) with ACS treated with primary angioplasty (PCI). The @entity0 were divided into 2 subgroups: 43 @entity0 with @entity1 ( @entity10 ) and 50 non- @entity1 (non- @entity10 ). @entity0 were examined on the 3rd day after ACS and after 6 months. @entity6 on the 3rd day were significantly lower in @entity10 than in non- @entity10 (5.8    2.2% vs. 8.8    4.9%, p=0.0007) and after 6 months (6.2    2.6% vs. 9.4    4.4%, p<0.0001). It was also observed that the improvement of @entity6 in both groups after a 6-month follow-up inversely correlated with the increase of left ventricular end-diastolic volume (LVEDV) (r=-0.41, p<0.001). RESULTS: There was an inverse relationship between @entity6 and age (r=-0.26, p<0.01), BMI (r=-0.26, p<0,005), total @entity3 (r=-0.56, p<0.001) and LDL @entity3 (r=-0.53, p<0.001). There was no relationship between @entity9 , @entity2 and history of smoking. In the @entity10 group, @entity6 negatively correlated with HbA1c (r=-0.68, p<0.001). @entity4 rate was significantly higher in the @entity10 group (19% vs. 6%, p<0.001) but there was no relationship between @entity6 and @entity4 . CONCLUSIONS: Impaired @entity6 is more significant in @entity1 than in non- @entity1 @entity0 with ACS. Lack of improvement of @entity6 after @entity8 can be a predictor of detrimental left ventricular remodeling in @entity0 with ACS.

title: Endothelial function and left ventricular remodeling in @entity1 and non- XXXX @entity0 after @entity8 .

answer: @entity1


abstract: BACKGROUND: @entity7 is an independent predictor of future @entity5 . MATERIAL/METHODS: We evaluated the relationship between @entity6 ( @entity6 ) in brachial artery and coronary risk factors in 93 @entity0 (70 males, mean age: 62    8 years) with ACS treated with primary angioplasty (PCI). The @entity0 were divided into 2 subgroups: 43 @entity0 with @entity1 ( @entity10 ) and 50 non- @entity1 (non- @entity10 ). @entity0 were examined on the 3rd day after ACS and after 6 months. @entity6 on the 3rd day were significantly lower in @entity10 than in non- @entity10 (5.8    2.2% vs. 8.8    4.9%, p=0.0007) and after 6 months (6.2    2.6% vs. 9.4    4.4%, p<0.0001). It was also observed that the improvement of @entity6 in both groups after a 6-month follow-up inversely correlated with the increase of left ventricular end-diastolic volume (LVEDV) (r=-0.41, p<0.001). RESULTS: There was an inverse relationship between @entity6 and age (r=-0.26, p<0.01), BMI (r=-0.26, p<0,005), total @entity3 (r=-0.56, p<0.001) and LDL @entity3 (r=-0.53, p<0.001). There was no relationship between @entity9 , @entity2 and history of smoking. In the @entity10 group, @entity6 negatively correlated with HbA1c (r=-0.68, p<0.001). @entity4 rate was significantly higher in the @entity10 group (19% vs. 6%, p<0.001) but there was no relationship between @entity6 and @entity4 . CONCLUSIONS: Impaired @entity6 is more significant in @entity1 than in non- @entity1 @entity0 with ACS. Lack of improvement of @entity6 after @entity8 can be a predictor of detrimental left ventricular remodeling in @entity0 with ACS.

title: Endothelial function and left ventricular remodeling in XXXX and non- @entity1 @entity0 after @entity8 .

answer: @entity1


abstract: BACKGROUND: @entity7 is an independent predictor of future @entity5 . MATERIAL/METHODS: We evaluated the relationship between @entity6 ( @entity6 ) in brachial artery and coronary risk factors in 93 @entity0 (70 males, mean age: 62    8 years) with ACS treated with primary angioplasty (PCI). The @entity0 were divided into 2 subgroups: 43 @entity0 with @entity1 ( @entity10 ) and 50 non- @entity1 (non- @entity10 ). @entity0 were examined on the 3rd day after ACS and after 6 months. @entity6 on the 3rd day were significantly lower in @entity10 than in non- @entity10 (5.8    2.2% vs. 8.8    4.9%, p=0.0007) and after 6 months (6.2    2.6% vs. 9.4    4.4%, p<0.0001). It was also observed that the improvement of @entity6 in both groups after a 6-month follow-up inversely correlated with the increase of left ventricular end-diastolic volume (LVEDV) (r=-0.41, p<0.001). RESULTS: There was an inverse relationship between @entity6 and age (r=-0.26, p<0.01), BMI (r=-0.26, p<0,005), total @entity3 (r=-0.56, p<0.001) and LDL @entity3 (r=-0.53, p<0.001). There was no relationship between @entity9 , @entity2 and history of smoking. In the @entity10 group, @entity6 negatively correlated with HbA1c (r=-0.68, p<0.001). @entity4 rate was significantly higher in the @entity10 group (19% vs. 6%, p<0.001) but there was no relationship between @entity6 and @entity4 . CONCLUSIONS: Impaired @entity6 is more significant in @entity1 than in non- @entity1 @entity0 with ACS. Lack of improvement of @entity6 after @entity8 can be a predictor of detrimental left ventricular remodeling in @entity0 with ACS.

title: Endothelial function and left ventricular remodeling in @entity1 and non- @entity1 @entity0 after XXXX .

answer: @entity8


abstract: BACKGROUND: @entity7 is an independent predictor of future @entity5 . MATERIAL/METHODS: We evaluated the relationship between @entity6 ( @entity6 ) in brachial artery and coronary risk factors in 93 @entity0 (70 males, mean age: 62    8 years) with ACS treated with primary angioplasty (PCI). The @entity0 were divided into 2 subgroups: 43 @entity0 with @entity1 ( @entity10 ) and 50 non- @entity1 (non- @entity10 ). @entity0 were examined on the 3rd day after ACS and after 6 months. @entity6 on the 3rd day were significantly lower in @entity10 than in non- @entity10 (5.8    2.2% vs. 8.8    4.9%, p=0.0007) and after 6 months (6.2    2.6% vs. 9.4    4.4%, p<0.0001). It was also observed that the improvement of @entity6 in both groups after a 6-month follow-up inversely correlated with the increase of left ventricular end-diastolic volume (LVEDV) (r=-0.41, p<0.001). RESULTS: There was an inverse relationship between @entity6 and age (r=-0.26, p<0.01), BMI (r=-0.26, p<0,005), total @entity3 (r=-0.56, p<0.001) and LDL @entity3 (r=-0.53, p<0.001). There was no relationship between @entity9 , @entity2 and history of smoking. In the @entity10 group, @entity6 negatively correlated with HbA1c (r=-0.68, p<0.001). @entity4 rate was significantly higher in the @entity10 group (19% vs. 6%, p<0.001) but there was no relationship between @entity6 and @entity4 . CONCLUSIONS: Impaired @entity6 is more significant in @entity1 than in non- @entity1 @entity0 with ACS. Lack of improvement of @entity6 after @entity8 can be a predictor of detrimental left ventricular remodeling in @entity0 with ACS.

title: Endothelial function and left ventricular remodeling in @entity1 and non- @entity1 XXXX after @entity8 .

answer: @entity0


abstract: OBJECTIVE: This study examined the risk factors for @entity1 and the efficacy of prophylactic cerclage in @entity0 who had undergone cervical conization due to @entity2 before pregnancy. METHODS: We reviewed the medical records of all @entity0 who gave live singleton births between May 1996 and April 2009, after having cervical conization. Delivery before 37 gestational weeks was considered as @entity1 . The pregnancy outcomes were analyzed with independent sample t-test, chi-square test, and multiple logistic regression using the SPSS ver. 12.0. RESULTS: Sixty five cases were found. The mean gestational age at delivery was 37 weeks (SD, 3.5). Eighteen @entity0 (27.7%) had @entity3 . The type of conization, the volume of the specimen, and second trimester cervical length were related to @entity1 (p <=0.001, p=0.019, p <=0.001, respectively). In multivariate analysis, only mid-trimester cervical length was statistically significant for @entity1 (p=0.012; odds ratio, 0.194; confidence interval, 0.055 to 0.693). Six out of 65 @entity0 had undergone prophylactic cerclage, and three (50%) of them had preterm births, while 15 (25%) @entity0 without cerclage had preterm births. CONCLUSION: The type of conization, the volume of specimen, and second trimester cervical length may be the risk factors for @entity1 in @entity0 who have a prior history of cervical conization. Prophylactic cerclage may not be helpful in preventing @entity1 , therefore more careful consideration should be paid in deciding cerclage after conization during prenatal counseling.

title: Pregnancy outcome after cervical conization: risk factors for XXXX and the efficacy of prophylactic cerclage.

answer: @entity3


abstract: Holtzman male @entity0 were given four injections of saline or @entity2 at 31 micrograms/kg or 46 micrograms/kg. The injections were given every 3 days during a 2-week period. Tail vein blood samples, drawn 24 hr before the first injection and 24 hr after the last injection, were analyzed for @entity1 ( @entity1 ) inhibition. For the low and high @entity2 groups, whole blood @entity1 was inhibited 20 and 24%, respectively, while plasma @entity1 was inhibited 17 and 25%, respectively. Parallel saline injections produced a small inhibition of whole blood @entity1 and an increase in activity (negative inhibition) of plasma @entity1 . During the second week of @entity2 administration @entity0 began training on a discriminated shock avoidance task. The seven animals administered 46 micrograms/kg @entity2 did not learn the lever-pressing avoidance response during a period of 120 days. Five of eight saline @entity0 and four of seven 31 micrograms/kg @entity2 @entity0 learned the avoidance response. There was no significant difference between learners relative to rate of learning of the avoidance task. All of the @entity0 learned to escape the shocks. These data indicate that subchronic @entity2 inhibits learning of new behaviors by @entity0 .

title: Effects of subchronic administration of XXXX on acquisition of avoidance-escape behavior by @entity0 .

answer: @entity2


abstract: Holtzman male @entity0 were given four injections of saline or @entity2 at 31 micrograms/kg or 46 micrograms/kg. The injections were given every 3 days during a 2-week period. Tail vein blood samples, drawn 24 hr before the first injection and 24 hr after the last injection, were analyzed for @entity1 ( @entity1 ) inhibition. For the low and high @entity2 groups, whole blood @entity1 was inhibited 20 and 24%, respectively, while plasma @entity1 was inhibited 17 and 25%, respectively. Parallel saline injections produced a small inhibition of whole blood @entity1 and an increase in activity (negative inhibition) of plasma @entity1 . During the second week of @entity2 administration @entity0 began training on a discriminated shock avoidance task. The seven animals administered 46 micrograms/kg @entity2 did not learn the lever-pressing avoidance response during a period of 120 days. Five of eight saline @entity0 and four of seven 31 micrograms/kg @entity2 @entity0 learned the avoidance response. There was no significant difference between learners relative to rate of learning of the avoidance task. All of the @entity0 learned to escape the shocks. These data indicate that subchronic @entity2 inhibits learning of new behaviors by @entity0 .

title: Effects of subchronic administration of @entity2 on acquisition of avoidance-escape behavior by XXXX .

answer: @entity0


abstract: STUDY OBJECTIVE: To determine the effects of @entity3 ( @entity4 ) on heart rate and PR, @entity5 in @entity0 with longstanding @entity6 ( @entity6 ). DESIGN: Randomized, active-treatment-controlled, dose level-blinded study, with allocation concealed. SETTING: University-affiliated, tertiary care medical center. @entity0 : Sixty otherwise healthy male and female outpatients with traumatic @entity6 of more than 1 year's duration. Intervention. Oral administration and dose titration to tolerance of an immediate-release formulation of @entity4 . MEASUREMENTS AND MAIN RESULTS: The PR interval, heart rate, QT interval, and QTc interval obtained from standard 12-lead electrocardiograms (ECGs) at baseline (before administration of @entity4 ) and after 1 month of treatment were compared. The QTc intervals were derived by using Bazett's formula (equation) incorporated into standard computerized analyses of 12-lead ECG printouts. The paired t test was performed to test for the significance of differences between means and variances. No statistically significant differences were noted in heart rate or between ECG time intervals measured at baseline and after 1 month of treatment with @entity4 among all @entity0 with @entity6 or between subgroups stratified by injury level ( @entity7 , @entity2 ) or sex. CONCLUSION: During the 1-month period that @entity4 was administered, the heart rate and PR, @entity5 all remained unchanged and stayed well within normal range in comparison to literature-derived control values. @entity3 does not appear to influence the length of cardiac time intervals or heart rate and, hence, is unlikely to cause potentially life-threatening @entity1 when administered long-term and taken orally in dosages of up to 30 mg/day. Specifically, cardiac repolarization (QTc interval) is unaffected in @entity0 with @entity6 who continuously receive @entity4 for up to 1 month.

title: Effects of XXXX on cardiac repolarization, PR interval, and heart rate in @entity0 with @entity6 .

answer: @entity3


abstract: STUDY OBJECTIVE: To determine the effects of @entity3 ( @entity4 ) on heart rate and PR, @entity5 in @entity0 with longstanding @entity6 ( @entity6 ). DESIGN: Randomized, active-treatment-controlled, dose level-blinded study, with allocation concealed. SETTING: University-affiliated, tertiary care medical center. @entity0 : Sixty otherwise healthy male and female outpatients with traumatic @entity6 of more than 1 year's duration. Intervention. Oral administration and dose titration to tolerance of an immediate-release formulation of @entity4 . MEASUREMENTS AND MAIN RESULTS: The PR interval, heart rate, QT interval, and QTc interval obtained from standard 12-lead electrocardiograms (ECGs) at baseline (before administration of @entity4 ) and after 1 month of treatment were compared. The QTc intervals were derived by using Bazett's formula (equation) incorporated into standard computerized analyses of 12-lead ECG printouts. The paired t test was performed to test for the significance of differences between means and variances. No statistically significant differences were noted in heart rate or between ECG time intervals measured at baseline and after 1 month of treatment with @entity4 among all @entity0 with @entity6 or between subgroups stratified by injury level ( @entity7 , @entity2 ) or sex. CONCLUSION: During the 1-month period that @entity4 was administered, the heart rate and PR, @entity5 all remained unchanged and stayed well within normal range in comparison to literature-derived control values. @entity3 does not appear to influence the length of cardiac time intervals or heart rate and, hence, is unlikely to cause potentially life-threatening @entity1 when administered long-term and taken orally in dosages of up to 30 mg/day. Specifically, cardiac repolarization (QTc interval) is unaffected in @entity0 with @entity6 who continuously receive @entity4 for up to 1 month.

title: Effects of @entity3 on cardiac repolarization, PR interval, and heart rate in @entity0 with XXXX .

answer: @entity6


abstract: STUDY OBJECTIVE: To determine the effects of @entity3 ( @entity4 ) on heart rate and PR, @entity5 in @entity0 with longstanding @entity6 ( @entity6 ). DESIGN: Randomized, active-treatment-controlled, dose level-blinded study, with allocation concealed. SETTING: University-affiliated, tertiary care medical center. @entity0 : Sixty otherwise healthy male and female outpatients with traumatic @entity6 of more than 1 year's duration. Intervention. Oral administration and dose titration to tolerance of an immediate-release formulation of @entity4 . MEASUREMENTS AND MAIN RESULTS: The PR interval, heart rate, QT interval, and QTc interval obtained from standard 12-lead electrocardiograms (ECGs) at baseline (before administration of @entity4 ) and after 1 month of treatment were compared. The QTc intervals were derived by using Bazett's formula (equation) incorporated into standard computerized analyses of 12-lead ECG printouts. The paired t test was performed to test for the significance of differences between means and variances. No statistically significant differences were noted in heart rate or between ECG time intervals measured at baseline and after 1 month of treatment with @entity4 among all @entity0 with @entity6 or between subgroups stratified by injury level ( @entity7 , @entity2 ) or sex. CONCLUSION: During the 1-month period that @entity4 was administered, the heart rate and PR, @entity5 all remained unchanged and stayed well within normal range in comparison to literature-derived control values. @entity3 does not appear to influence the length of cardiac time intervals or heart rate and, hence, is unlikely to cause potentially life-threatening @entity1 when administered long-term and taken orally in dosages of up to 30 mg/day. Specifically, cardiac repolarization (QTc interval) is unaffected in @entity0 with @entity6 who continuously receive @entity4 for up to 1 month.

title: Effects of @entity3 on cardiac repolarization, PR interval, and heart rate in XXXX with @entity6 .

answer: @entity0


abstract: AIM OF STUDY: The study aimed to examine the knowledge and practice of @entity0 screening amongst Public Health nurses who are @entity1 educators. METHOD: A self-administered questionnaire was sent to all 447 nurses in the Public Health Service to assess their knowledge and practice of @entity0 screening. Response rate was 96.4%. Knowledge scores ranged from 0-17 with one point given to a correct knowledge question, zero for wrong answer. RESULTS: Median knowledge score was nine and 58.3% of nurses scored > or = 9. Statistically significant factors influencing knowledge scores were related to the nursing profession, namely nursing qualifications, current nursing post and current workplace. 76.2% of Nursing Officers/Higher Nursing Officers and 74.5% of midwives had knowledge scores > or = 9 compared with 57.3% of staff nurses and 40.8% of assistant nurses (p < 0.01). 60.1% of nurses who were taught breast-self examination scored > or = 9 (p < 0.05). As for practice, 93.7% of nurses did breast-self-examination, 54.1% had clinical breast examination in the past one year and 50.2% had mammogram done. On multivariate analysis, significant factors affecting practice of clinical breast examination were marital status (Prevalence Rate Ratio 1.94, 95% Confidence Interval 1.20-3.15), doctor's gender ( @entity3 .35, CI 1.04-1.75) and those affecting mammogram were age group ( @entity3 .78, CI 1.27-2.48), marital status ( @entity3 .63, CI 1.03-2.59), history of @entity2 ( @entity3 .51, CI 1.06-2.16). CONCLUSIONS: The majority of nurses had certain misconceptions in the knowledge of @entity0 and @entity0 screening. A higher proportion of nurses in the Family Health Service had higher knowledge scores than other nurses in the Public Health Service. Most of the nurses did breast-self-examination. Having ever married and the availability of a female doctor influenced the nurses attending clinical breast examination. Nurses who were > or = 50 years old, ever married and those with a positive history of @entity2 were more likely to have mammography done.

title: Knowledge and practice of XXXX screening amongst public health nurses in Singapore.

answer: @entity0


abstract: BACKGROUND: The limitation of clinical-epidemiological know-how and evidence regarding therapeutic efficiency in @entity1 among the elderly and extremely elderly @entity0 has given rise to an excessive variety of practices in clinical care of these @entity0 in the Spanish health system. The Spanish Society of Psychogeriatrics (SEPG) has raised the question of the need to unify criteria through a structured approach based on professional consensus. OBJECTIVES: To develop an expert consensus of clinical recommendations to improve the clinical treatment of @entity1 in elderly @entity0 in Spain, sponsored by the Spanish Society of Psychogeriatrics (SEPG). METHODS: Modified Delphi Consensus, in two rounds. The study was conducted in four phases: 1) constitution of a Scientific Committee, project promoter and responsible for bibliographic review and formulation of recommendations for discussion 2) constitution of a multicenter Panel of Experts with representatives from this specialist field 3) postal survey comprised of two rounds, with interim processing of opinions and a report for the experts and 4) discussion of results during an on-site meeting of the Scientific Committee. RESULTS: The survey evaluation was completed by 61 experts consulted, in two rounds. In the first round, consensus was reached in 39 of the 54 questions analyzed. Following interaction by the panel, this consensus was increased to a total of 46 survey items (85% of the proposed contents). It was impossible to obtain a sufficiently unanimous consensus on the remaining 8 questions, either due to differences of opinion among the professionals or a lack of established criterion in most of the experts. CONCLUSIONS: A full list of criteria and clinical recommendations for the purpose of rationalizing the treatment of @entity1 in elderly @entity0 and reducing excessive variability in clinical practice is presented. The recommendations are qualified in accordance with the degree of consensus of the professionals endorsing them and can be considered valid until new scientific information becomes available that justifies their review.

title: Consensus of the SEPG on XXXX in the elderly.

answer: @entity1


abstract: @entity4 resistance to antimicrobial agents is an important factor compromising the efficacy of treatment. Therefore the aims of our study were: to determine the prevalence of @entity4 resistance to @entity5 , @entity3 , @entity1 and @entity2 in @entity0 prior to eradication therapy, to compare different methods of susceptibility testing and to detect mutations responsible for @entity5 resistance. During 1996-2000, 259 @entity4 strains were isolated from antral gastric biopsies. Susceptibility to antimicrobials was determined by the agar dilution method and the Etest. Mutations in the 23S rRNA gene associated with @entity5 resistance were analysed by PCR-RFLP and direct sequencing. Overall, ninety-six strains (37%) were resistant to @entity3 , 50 strains (19.3%) were resistant to @entity5 , and 20 strains (7.7%) were simultaneously resistant to both drugs. All cultured isolates were sensitive to @entity1 and only one isolate (0.4%) was resistant to @entity2 . The agar dilution method and the Etest showed a perfect category correlation for @entity5 and 4% discrepancies for @entity3 . Primary resistance to @entity5 was mainly associated with an @entity6 mutation in the 23S rRNA gene of @entity4 . The study highlights the high prevalence of @entity4 primary resistance to @entity5 in Polish @entity0 , which implies a need for pretreatment susceptibility testing.

title: Primary resistance of XXXX @entity4 to antimicrobial agents in Polish @entity0 .

answer: @entity4


abstract: @entity4 resistance to antimicrobial agents is an important factor compromising the efficacy of treatment. Therefore the aims of our study were: to determine the prevalence of @entity4 resistance to @entity5 , @entity3 , @entity1 and @entity2 in @entity0 prior to eradication therapy, to compare different methods of susceptibility testing and to detect mutations responsible for @entity5 resistance. During 1996-2000, 259 @entity4 strains were isolated from antral gastric biopsies. Susceptibility to antimicrobials was determined by the agar dilution method and the Etest. Mutations in the 23S rRNA gene associated with @entity5 resistance were analysed by PCR-RFLP and direct sequencing. Overall, ninety-six strains (37%) were resistant to @entity3 , 50 strains (19.3%) were resistant to @entity5 , and 20 strains (7.7%) were simultaneously resistant to both drugs. All cultured isolates were sensitive to @entity1 and only one isolate (0.4%) was resistant to @entity2 . The agar dilution method and the Etest showed a perfect category correlation for @entity5 and 4% discrepancies for @entity3 . Primary resistance to @entity5 was mainly associated with an @entity6 mutation in the 23S rRNA gene of @entity4 . The study highlights the high prevalence of @entity4 primary resistance to @entity5 in Polish @entity0 , which implies a need for pretreatment susceptibility testing.

title: Primary resistance of @entity4 XXXX to antimicrobial agents in Polish @entity0 .

answer: @entity4


abstract: @entity4 resistance to antimicrobial agents is an important factor compromising the efficacy of treatment. Therefore the aims of our study were: to determine the prevalence of @entity4 resistance to @entity5 , @entity3 , @entity1 and @entity2 in @entity0 prior to eradication therapy, to compare different methods of susceptibility testing and to detect mutations responsible for @entity5 resistance. During 1996-2000, 259 @entity4 strains were isolated from antral gastric biopsies. Susceptibility to antimicrobials was determined by the agar dilution method and the Etest. Mutations in the 23S rRNA gene associated with @entity5 resistance were analysed by PCR-RFLP and direct sequencing. Overall, ninety-six strains (37%) were resistant to @entity3 , 50 strains (19.3%) were resistant to @entity5 , and 20 strains (7.7%) were simultaneously resistant to both drugs. All cultured isolates were sensitive to @entity1 and only one isolate (0.4%) was resistant to @entity2 . The agar dilution method and the Etest showed a perfect category correlation for @entity5 and 4% discrepancies for @entity3 . Primary resistance to @entity5 was mainly associated with an @entity6 mutation in the 23S rRNA gene of @entity4 . The study highlights the high prevalence of @entity4 primary resistance to @entity5 in Polish @entity0 , which implies a need for pretreatment susceptibility testing.

title: Primary resistance of @entity4 @entity4 to antimicrobial agents in Polish XXXX .

answer: @entity0


abstract: Using 13 @entity0 undergoing operation of the bile duct, @entity3 ( @entity4 ) transport into the bile and the gallbladder tissue was investigated. One gram of @entity4 was administered through drip infusion over 30 minutes every 12 hours. @entity4 concentration in bile was measured for samples surgically collected about 103 minutes (75-141 minutes) after the start of @entity4 administration. @entity4 concentrations in bile samples collected from gallbladder were found to be as high as 326.6 +/- 432.3 micrograms/ml in @entity0 with neither @entity1 nor @entity2 , indicating sufficient @entity4 transport. When @entity2 were present, @entity4 concentrations were very low, or moderately @entity1 was also present. Changes in @entity4 concentration were then measured over 6 hours after administration in @entity0 with an external biliary fistula every other day for a period of 7 days, from the first postoperation day. As for horal changes, @entity4 concentration reached its peak in 2 hours after the start of administration in most cases. Maximum @entity4 concentrations in @entity0 without @entity1 were high, ranging from 313.3 to 1,232.3 micrograms/ml (mean, 641.2 micrograms/ml), and @entity4 was found at 4.0-76.6 micrograms/ml (mean, 37.4 micrograms/ml), even after 6 hours. As for diurnal changes, @entity4 was determined to be sufficiently transported into the bile from the first postoperation day. Although @entity4 concentrations tended to be lower on the fifth postoperation day than on other days, there was no statistical significance in differences in daily concentrations examined. @entity4 concentrations in gallbladder tissues were determined to be 22.7 4/- 32.1 micrograms/g, and they decreased over time exponentially.

title: [ XXXX transport into the bile, especially in the intra- and postoperative periods].

answer: @entity3


abstract: BACKGROUND: The relative effectiveness of flexible sigmoidoscopy compared with colonoscopy to screen for @entity2 depends on the magnitude of the association between findings in the proximal and distal colon and the false-negative rate of screening sigmoidoscopy for proximal @entity1 . To address this, we performed a systematic review and meta-analysis of screening colonoscopy studies. METHODS: Published studies through July 31, 2000, of asymptomatic @entity0 undergoing screening colonoscopy were identified from the MEDLINE database. We generated pooled estimates of the odds ratio for the association between findings in the distal and proximal colon and the prevalence of isolated proximal @entity4 . RESULTS: Using the sigmoid-descending colon junction to identify the beginning of the distal colon, the pooled odds ratio for the association between distal @entity5 and any proximal @entity1 was 2.40 (95% confidence interval [CI], 1.42-4.05). Diminutive distal @entity5 were also associated with proximal @entity1 (odds ratio, 2.36; 95% CI, 1.30-4.29). @entity3 were not associated with proximal @entity1 (odds ratio, 1.44; 95% CI, 0.79-2.62). The prevalence of isolated advanced proximal @entity1 in the 3 studies was 2%, 3%, and 5%. Using the sigmoid-descending colon junction to identify the beginning of the distal colon yields a pooled estimate of isolated proximal @entity1 of 16.3% (95% CI, 13.6%-19.1%). CONCLUSIONS: Distal @entity5 , including diminutive distal @entity5 , are associated with an increased prevalence of @entity1 . Two percent to 5% of @entity0 undergoing screening colonoscopy may have isolated advanced proximal @entity1 . Even more @entity0 may have isolated nonadvanced proximal @entity1 .

title: Detection of proximal XXXX with screening sigmoidoscopy: a systematic review and meta-analysis of screening colonoscopy.

answer: @entity5


abstract: Thirty-four heifers (24 Holstein, 8 Ayrshire, 2 Jersey) and 12 Holstein steer @entity0 were grouped into 23 blocks of 2 animals each according to breed, sex, and body weight. Animals in each block were randomly assigned to control or treated groups. The treated group received an anthelmintic bolus containing morantel tartrate before they were permitted access to pasture. A 2.6 ha pasture was divided in half with a double fence; the resulting two pastures had separate feed and water troughs. Steer @entity0 were slaughtered upon termination of the trial to ascertain @entity1 burdens. Two worm-free tracer @entity0 were placed on each pasture every 2 mo and slaughtered after 4 wk of grazing to determine parasite infectivity of pastures. Herbage samples were obtained monthly and analyzed for infective larvae. The trial was conducted for 141 d during the grazing season. Treatment resulted in 90% reduction in infective larvae on pasture, 74% reduction in fecal worm-eggs, 91% reduction in adult worm burdens, and a trend toward reduced worm burdens in tracer @entity0 by 52%. An overall average daily gain of .68 and .88 kg was obtained for control and treated animals. Reproductive data for the heifers remaining in the herd from the trial showed that treatment resulted in 44 less days to first breeding.

title: Efficacy of morantel tartrate in a sustained release bolus on the control of subclinical XXXX in first-year grazing dairy replacements.

answer: @entity1


abstract: BACKGROUND: Since the 1960s, group A streptococcus (GAS) has accounted for less than 1% of cases of community-acquired @entity3 . During the @entity8 decades there has been a resurgence of @entity1 , but no large study of @entity7 has been performed. METHODS: To determine the clinical and epidemiologic features of @entity7 , we conducted prospective, population-based surveillance of all @entity1 in residents of Ontario from January 1, 1992, through December 31, 1999. RESULTS: Of 2079 cases of @entity1 , 222 (11%) represented @entity7 . The incidence of @entity7 ranged from 0.16 per 100 000 in 1992 to 0.35 per 100 000 in 1999. Most cases were community acquired (81%). Forty-four percent of nursing home-acquired cases occurred during outbreaks. The case fatality rate was 38% for @entity7 , compared with 12% for the entire cohort with @entity1 and 26% for @entity0 with @entity2 . The presence of streptococcal @entity4 (odds ratio, 19; 95% confidence interval, 8.4-42; P =.001) and increasing age (odds ratio per decade, 1.45; 95% confidence interval, 1.2-1.7; P<.001) were associated with fatal outcome. Time to @entity5 was rapid, with a median of 2 days despite antimicrobial therapy and supportive measures. CONCLUSIONS: Group @entity6 is a common form of @entity1 but remains an uncommon cause of community-acquired @entity3 . Progression is rapid despite appropriate therapy. The incidence is similar to, and the case fatality rate higher than, that of @entity2 .

title: Clinical and epidemiologic features of group a XXXX in Ontario, Canada.

answer: @entity6


abstract: BACKGROUND: Autologous blood therapy ( @entity4 ) is used for treating @entity3 ( @entity3 ) in some European countries and is promoted on internet sites for this condition. However, there is little evidence from rigorous clinical trials to suggest that it is effective. OBJECTIVES: To test the effectiveness of @entity4 for the symptomatic treatment of @entity0 with @entity3 . METHODS: Fifty subjects responded to press advertisements, and 31 were randomized within strata of severity at recruitment. @entity0 were included into a double-blind, placebo-controlled trial and received @entity4 or placebo once weekly for 5 weeks. Assessments were performed at baseline, at weekly intervals and after a 5-week follow up. The Six Area, Six Sign @entity3 (SASSAD) severity index was predefined as the primary outcome measure. The Dermatology Life Quality Index and @entity0 ratings of @entity2 , @entity1 and skin appearance on 100-mm visual analogue scales were defined as secondary outcome measures. Success of @entity0 blinding and adverse events were assessed. RESULTS: Data were analysed on an intention-to-treat basis. Analysis of covariance suggested a significant differential change of the SASSAD score between baseline and the end of the follow-up period in favour of @entity4 . The mean reduction in SASSAD score was 13.5 points (95% confidence interval, CI 6.6-20.4, P < 0.001) over and above placebo; the corresponding value at the end of treatment was 9.6 (95% CI 4.2-14.9, P = 0.001). No clear significant intergroup differences in any of the secondary outcome measures were found. Six @entity0 in the @entity4 group and seven in the placebo group reported minor and transient adverse events. CONCLUSIONS: These data suggest that, according to the SASSAD score, @entity4 has beneficial effects in the treatment of @entity3 , although this was not confirmed by the @entity0 -rated assessments. The improvement in observer-rated skin condition suggested by this study needs confirmation in larger trials.

title: Randomized, double-blind, placebo-controlled trial of autologous blood therapy for XXXX .

answer: @entity3


abstract: Nodular sclerotic change in @entity1 ( @entity1 ) is not a well-recognized event. @entity3 is reported in three @entity0 with @entity1 : a 33-year-old @entity0 with a left subclavian mass, a 29-year-old @entity0 with a mass on the left crus and a 31-year-old @entity0 with a mass on the left cheek. Histologically, lesions consisted of two types of feature, one type being typical of @entity1 and the other being rich in collagen. In the first @entity0 , each type formed a distinct compartment, each of which contained scattered cells containing melanin pigment. In the second @entity0 , foci with typical @entity1 histology were distributed within the collagen-rich area and also formed a substantial compartment in the periphery of the lesion, with pigmented cells being distributed mainly in and around the cellular area. In the third @entity0 , the collagenous area occupied about half of the lesion. There was no pigmentation. In all three cases the collagen-rich area contained sparsely distributed fibroblast-like cells that stained positive with @entity2 . @entity3 in @entity1 could cause substantial difficulty in diagnosis if the biopsy material were partial and small. The clinical history and knowledge about the existence of this kind of histological variation in @entity1 are important.

title: Nodular sclerotic change in XXXX : a potential diagnostic problem.

answer: @entity1


abstract: The value of @entity5 positron emission tomography/computed tomography (FDG PET/CT) in the detection of @entity4 ( @entity4 ) differs among the studies. This study aimed to evaluate the role of @entity7 -FDG PET/CT in @entity4 . Fifty-one @entity0 (19 @entity0 , 32 @entity0 ) with @entity2 confirmed by histopathology from an unknown @entity3 were included in this study. @entity0 received 370 MBq of @entity5 intravenously, and PET/CT was performed at 60 minutes after injection. Primary @entity3 sites were detected in 5 of 51 @entity0 (9.6%): in 2 @entity0 with @entity1 , in 1 @entity0 with @entity6 , in 1 @entity0 with @entity4 , and in 1 @entity0 with @entity4 . No @entity3 was discovered in the remaining 46 @entity0 (90.4%) during the follow-up. The sensitivity, specificity, and accuracy of @entity7 -FDG PET/CT were 100%, 80.4%, and 82.4%. The positive and negative predictive values were 35.7 and 100%, respectively. Based on the data presented, @entity7 -FDG PET/CT has a clinical implicative value in detecting the @entity3 of @entity4 . PET/CT can be useful to rule out the possibility of detecting the @entity3 during the follow-up.

title: Clinical implication of @entity5 PET/CT in XXXX .

answer: @entity4


abstract: The value of @entity5 positron emission tomography/computed tomography (FDG PET/CT) in the detection of @entity4 ( @entity4 ) differs among the studies. This study aimed to evaluate the role of @entity7 -FDG PET/CT in @entity4 . Fifty-one @entity0 (19 @entity0 , 32 @entity0 ) with @entity2 confirmed by histopathology from an unknown @entity3 were included in this study. @entity0 received 370 MBq of @entity5 intravenously, and PET/CT was performed at 60 minutes after injection. Primary @entity3 sites were detected in 5 of 51 @entity0 (9.6%): in 2 @entity0 with @entity1 , in 1 @entity0 with @entity6 , in 1 @entity0 with @entity4 , and in 1 @entity0 with @entity4 . No @entity3 was discovered in the remaining 46 @entity0 (90.4%) during the follow-up. The sensitivity, specificity, and accuracy of @entity7 -FDG PET/CT were 100%, 80.4%, and 82.4%. The positive and negative predictive values were 35.7 and 100%, respectively. Based on the data presented, @entity7 -FDG PET/CT has a clinical implicative value in detecting the @entity3 of @entity4 . PET/CT can be useful to rule out the possibility of detecting the @entity3 during the follow-up.

title: Clinical implication of XXXX PET/CT in @entity4 .

answer: @entity5


abstract: A group of 168 families who lived in a peri-urban slum in Santiago were surveyed for 9 months. All of them had a @entity0 under 7 years of age. Medical activities and data collection were carried out at a Field Station and by means of twice-weekly visits to each home, at which time cases of @entity1 were recorded and investigated. Faecal samples for bacteriological, parasitological and rotavirus studies were obtained during each episode. The characteristics of clinical course, hygienic practices in the family, and monthly anthropometric measurements of @entity0 and toddlers were also recorded. The mean monthly incidence of @entity1 was 7.1 episodes per 100 @entity0 . Of the episodes, 44.2% were associated with pathogenic bacteria, 14.4% with rotavirus, 38.4% with parasites and in 27.9% no enteropathogens were identified. It was found that adequate hygienic habits were not associated with a decreased risk of developing @entity1 and that about 60% of @entity0 did not have @entity1 throughout the study period. The nutritional status was adequate in most cases: weight-for-age was below the 5th percentile in 11.5% of subjects and the height-for-age was normal in all. No moderate or severe cases of @entity2 were detected.

title: Acute diarrhoeal disease in XXXX under 7 years of age in a peri-urban slum of Santiago, Chile.

answer: @entity0


abstract: OBJECT: The dynamics of fluid flow in normal pressure @entity2 (NPH) are poorly understood. Normally, @entity3 flows out of the brain through the ventricles. However, @entity1 during NPH may be caused by @entity3 backflow into the brain through the ventricles. A previous study showed this reversal of flow; in the present study, the authors provide additional clinical data obtained in @entity0 with NPH and supplement these data with computer simulations to better understand the @entity3 flow and ventricular wall displacement and emphasize its clinical implications. METHODS: Three NPH @entity0 and 1 @entity0 with @entity2 underwent cine phase-contrast MR imaging (cine MR imaging) for measurement of @entity3 flow and ventricle wall movement during the cardiac cycle. These data were compared to data previously obtained in 8 healthy volunteers. The @entity3 flow measurements were obtained at the outlet of the aqueduct of Sylvius. Calculation of the ventricular wall movement was determined from the complete set of cine MR images obtained axially at the middle of the lateral ventricle. The data were obtained before and after @entity3 removal with a ventriculoperitoneal shunt with an adjustable valve. To supplement the clinical data, a computational model was used to predict the transmural pressure and flow. RESULTS: In healthy volunteers, net @entity3 aqueductal flow was 1.2 ml/minute in the craniocaudal direction. In @entity0 with NPH, the net @entity3 flow was in the opposite direction--the caudocranial direction--before shunt placement. After shunting, the magnitude of the abnormal fluid flow decreased or reversed, with the flow resembling the normal flow patterns observed in healthy volunteers. CONCLUSIONS: The authors' MR imaging-based measurements of the @entity3 flow direction and lateral ventricle volume size change and the results of computer modeling of fluid dynamics lead them to conclude that the directional pattern and magnitude of @entity3 flow in @entity0 with NPH may be an indication of the disease state. This has practical implications for shunt design and understanding the mechanisms that produce @entity2 .

title: Ventricle wall movements and cerebrospinal fluid flow in XXXX .

answer: @entity2