abstract: AIMS: In 2011, we demonstrated that an individualized health management system employing advanced medical information technology, designated ubiquitous (u)-healthcare, was helpful in achieving glycemic control without @entity5 in @entity0 with @entity1 . Following this, we generated a new multidisciplinary u-healthcare system by upgrading our clinical decision support system (CDSS) rule engine and integrating a physical activity-monitoring device and dietary feedback into a comprehensive package. METHODS: In a randomized, controlled clinical trial, @entity0 with @entity2 2 @entity1 aged over 60  years were assigned randomly to a self-monitored blood @entity3 (SMBG) group (N  =  50) or u-healthcare group (N  =  50) for 6  months. The primary endpoint was the proportion of @entity0 achieving glycated hemoglobin (HbA1c) <7  % without @entity5 . Changes in body composition and lipid profiles were also investigated. The u-healthcare group was educated to use a specially designed glucometer and an activity monitor that automatically transferred test results to a hospital-based server. An automated CDSS rule engine generated and sent @entity0 -specific messages about @entity3 , diet, and physical activity to their mobile phones and a Web site. RESULTS: After 6  months of follow-up, the HbA1c level was significantly decreased in the u-healthcare group [8.0      0.7  % (64.2      8.8  mmol/mol) to 7.3      0.9  % (56.7      9.9  mmol/mol)] compared with the SMBG group [8.1      0.8  % (64.9      9.1  mmol/mol) to 7.9      1.2  % (63.2      12.3  mmol/mol)] (P  <  0.01). The proportion of @entity0 with @entity4 c  <  7  % without @entity5 was greater in the u-healthcare group (26  %) than in the SMBG group (12  %; P  <  0.05). Body fat mass decreased and lipid profiles improved in the u-healthcare group but not in the SMBG group. CONCLUSION: This u-healthcare service provided effective management for older @entity0 with @entity2 2 @entity1 (ClinicalTrial.Gov: NCT01137058).

title: Multifactorial intervention in @entity1 care using real-time monitoring and tailored feedback in @entity2 2 XXXX .

answer: @entity1


abstract: OBJECTIVES: evaluation of a centralised collection of clinical data (Service) within @entity1 screening programmes in Piedmont based on a hub_spoke model and its impact on process indicators. DESIGN: assessment of an organisational intervention, through a non-controlled pre-post design. SETTING AND @entity0 : organised screening programmes within the Piedmont Region, divided into 9 departments. MAIN OUTCOME MEASURES: clinical data (extracted from medical charts for mammography screening and from excision histology reports for cervical screening) obtained through the Service were quantified and their completeness was assessed. The Service impact on the detection rate (DR) was evaluated, comparing the DR pre- (2005-2008) and post-Service (2009- 2012) within breast screening; the DR was computed through histological diagnosis made during colposcopy (pre-Service method) or through the worst diagnosis between the latter and that reported from excision histology (post-Service method) within cervical screening (data available for department 1, year 2013). Some hints on @entity0 resources employed in pre- and post-Service periods were reported. RESULTS: within mammography screening, the Service obtained 53.1% of extra-department medical charts and 45.8% of extra-region ones; the percentage of missing diagnoses changed from 5.5% (pre- Service) to 3.7% (post-Service). The age standardised DR for @entity1 in the post-Service period is 1.3 times the DR of the pre-Service period per 1,000 screening tests. Within cervical screening, 51.7% of histological reports was recorded. Crude DR for high-grade lesions changed from 3.9 (pre-Service) to 4.7 (post-Service) per 1,000 screened @entity0 . The system centralisation did not imply an increase in the dedicated personnel. CONCLUSION: the Service is an operational core which coordinates the collection of clinical data, impacting on process indicators without an increase in @entity0 resources at departmental level.

title: [Introduction of a centralised system (Service) for collecting clinical data in XXXX screening programmes in Piedmont (Northern Italy): a pre-post assessment of a hub_spoke model].

answer: @entity1


abstract: INTRODUCTION: We report a case of @entity7 that was initially diagnosed as an ectopic pregnancy with a concomitant invasive @entity9 . CASE PRESENTATION: A 35-year-old @entity0 , gravida 4 para 3, presented to an outside hospital with @entity11 and @entity10 . Diagnosed with ectopic pregnancy, the @entity0 was brought to the operating room. Examination under anesthesia revealed a fungating cervical mass. A biopsy was obtained, but dilatation and curettage was deemed too dangerous. The @entity0 was empirically treated with @entity8 . The gynecology team at Einstein was contacted when the cervical biopsy returned as poorly differentiated @entity5 . The @entity0 was taken to the operating room by a gynecologic oncologist for a staging procedure, further cervical biopsy, and a failed attempt at dilatation and curettage. Pathology showed invasive poorly differentiated @entity3 with focal areas of squamous differentiation, extensive @entity6 , @entity2 , and @entity4 . The @entity0 began chemotherapy with plans for radiation therapy. The b @entity0 chorionic gonadotropin (b-hCG) levels continued to plateau. The case was brought to the @entity1 board and the potential for a @entity7 was then raised. The slides were reviewed and restained. With this information the diagnosis of @entity7 was made. The chemotherapy was adjusted and the b-hCG began to fall. DISCUSSION: The case demonstrates the importance of trending b-hCG levels in the absence of a pathology report confirming products of conception. This case also demonstrates the importance of interdisciplinary discussion and review of cases to provide quality care.

title: A Case of XXXX Initially Diagnosed as an Ectopic Pregnancy With a Concomitant @entity9 [199].

answer: @entity7


abstract: INTRODUCTION: We report a case of @entity7 that was initially diagnosed as an ectopic pregnancy with a concomitant invasive @entity9 . CASE PRESENTATION: A 35-year-old @entity0 , gravida 4 para 3, presented to an outside hospital with @entity11 and @entity10 . Diagnosed with ectopic pregnancy, the @entity0 was brought to the operating room. Examination under anesthesia revealed a fungating cervical mass. A biopsy was obtained, but dilatation and curettage was deemed too dangerous. The @entity0 was empirically treated with @entity8 . The gynecology team at Einstein was contacted when the cervical biopsy returned as poorly differentiated @entity5 . The @entity0 was taken to the operating room by a gynecologic oncologist for a staging procedure, further cervical biopsy, and a failed attempt at dilatation and curettage. Pathology showed invasive poorly differentiated @entity3 with focal areas of squamous differentiation, extensive @entity6 , @entity2 , and @entity4 . The @entity0 began chemotherapy with plans for radiation therapy. The b @entity0 chorionic gonadotropin (b-hCG) levels continued to plateau. The case was brought to the @entity1 board and the potential for a @entity7 was then raised. The slides were reviewed and restained. With this information the diagnosis of @entity7 was made. The chemotherapy was adjusted and the b-hCG began to fall. DISCUSSION: The case demonstrates the importance of trending b-hCG levels in the absence of a pathology report confirming products of conception. This case also demonstrates the importance of interdisciplinary discussion and review of cases to provide quality care.

title: A Case of @entity7 Initially Diagnosed as an Ectopic Pregnancy With a Concomitant XXXX [199].

answer: @entity9


abstract: 1. @entity4 nucleotide transhydrogenase from @entity1 was purified with a scaled-up procedure. In a typical purification 500 ml cell-free extract from 200 g cells is loaded on an Ado-2',5'-P2--Sepharose 4B affinity column (20 ml bed volume). After washing, the enzyme is desorbed with @entity5 at neutral pH and further purified by Sephadex G-200 gel chromatography. The enzyme (10--12 mg) is obtained in 40--60% yield and is homogeneous as judged by @entity3 gel electrophoresis in the presence of @entity0 . 2. The homogeneity of the purified enzyme is also apparent from electron microscopy studies, where the enzyme appears as a polydisperse set of polymers without contaminating structures and from fluorescence lifetime studies by the method of single-photon counting. The @entity2 fluorescence appears to decay with a single lifetime tau = 2.5 ns. The polymeric nature of transhydrogenase can be aptly demonstrated by density gradient centrifugation in the presence of KBr. After centrifuging for 50 h at 160 000 X g and 10 degrees C the enzyme is concentrated in a narrow fluorescent band with buoyant density rho b = 1.305 g cm-3. 3. The arrangement of subunits in the transhydrogenase polymer has been derived from optical diffraction studies of electron micrographs. The polymers are built up from a linear assembly of tetramers. Four subunits are placed in a rhomb with sides of 13.5 mm and an angle of 45 degrees (135 degrees) between the sides. A second tetramer is located staggered on top of the first one. Since a variety of other studies have indicated that the polymers dissociate into octamers under alkaline conditions [Voordouw, G. et al. (1979 Eur. J. Biochem. 98,447--454] we conclude that this smallest functional unit is build up from two tetramers.

title: Pyridine nucleotide transhydrogenase from XXXX . Improved purification, physical properties and subunit arrangement in purified polymers.

answer: @entity1


abstract: INTRODUCTION: @entity4 is common with a prevalence of 15% among adult @entity0 in the United States. We sought to identify key presenting characteristics for @entity2 in @entity0 as a primary source of chronic @entity5 . METHODS: We performed a retrospective cohort study from March 2009 to February 2014 of females with chronic @entity5 referred by their gynecologist to a surgeon specializing in @entity3 . Standardized preoperative questionnaires and an examination targeting @entity2 were completed. @entity0 with a high heightened suspicion for groin @entity3 underwent surgical exploration and repair along with concomitant gynecologic procedures if indicated. RESULTS: Of the 38 @entity0 referred and evaluated, 19 (50%) were considered candidates for groin exploration. Sixteen of the 18 (88.9%) @entity0 who underwent surgical exploration were confirmed to have @entity2 , which were subsequently repaired. No single preoperative historical factor or subjective @entity1 complaint was predictive of a @entity3 . Point tenderness at the internal inguinal ring was the only significant finding among those with proven @entity3 (P=.009, odds ratio 25). Among those who underwent repair, preoperative @entity1 scores significantly decreased from 7.2 of 10 to 3.1 of 10 within 2 weeks of surgery (P<.001). CONCLUSION: @entity2 represent a known cause of chronic @entity5 in @entity0 . Tenderness at the internal inguinal ring is strongly associated with the diagnosis of occult @entity2 in such @entity0 . With such a dramatic and rapid improvement in @entity1 that appears to be long-lasting, collaboration between gynecologists and @entity3 specialists may improve care for @entity0 with chronic @entity5 .

title: Inguinal @entity3 as a Cause of XXXX : A Key Sign to Make the Diagnosis [215].

answer: @entity4


abstract: INTRODUCTION: @entity4 is common with a prevalence of 15% among adult @entity0 in the United States. We sought to identify key presenting characteristics for @entity2 in @entity0 as a primary source of chronic @entity5 . METHODS: We performed a retrospective cohort study from March 2009 to February 2014 of females with chronic @entity5 referred by their gynecologist to a surgeon specializing in @entity3 . Standardized preoperative questionnaires and an examination targeting @entity2 were completed. @entity0 with a high heightened suspicion for groin @entity3 underwent surgical exploration and repair along with concomitant gynecologic procedures if indicated. RESULTS: Of the 38 @entity0 referred and evaluated, 19 (50%) were considered candidates for groin exploration. Sixteen of the 18 (88.9%) @entity0 who underwent surgical exploration were confirmed to have @entity2 , which were subsequently repaired. No single preoperative historical factor or subjective @entity1 complaint was predictive of a @entity3 . Point tenderness at the internal inguinal ring was the only significant finding among those with proven @entity3 (P=.009, odds ratio 25). Among those who underwent repair, preoperative @entity1 scores significantly decreased from 7.2 of 10 to 3.1 of 10 within 2 weeks of surgery (P<.001). CONCLUSION: @entity2 represent a known cause of chronic @entity5 in @entity0 . Tenderness at the internal inguinal ring is strongly associated with the diagnosis of occult @entity2 in such @entity0 . With such a dramatic and rapid improvement in @entity1 that appears to be long-lasting, collaboration between gynecologists and @entity3 specialists may improve care for @entity0 with chronic @entity5 .

title: Inguinal XXXX as a Cause of @entity4 : A Key Sign to Make the Diagnosis [215].

answer: @entity3


abstract: UNASSIGNED: Data regarding availability of @entity8 ( @entity7 ) and its impact on the stabilization, transport, critical care course, and surgical outcome of @entity0 with ductal-dependent @entity2 in the current pediatric healthcare environment are unknown. We sought to determine the proportion of hospitals in Texas that stock @entity7 and to investigate associations between @entity7 availability and clinical outcomes. All birth institutions listed with the Texas Department of Health and @entity0 Services were contacted to determine @entity7 availability as of 2011. Outcomes of all @entity0 admitted to our institution from 2007 to 2012 who received @entity7 for @entity1 were evaluated. @entity7 was stocked in 50  % (n  =  139) of hospitals that performed deliveries in Texas in 2011 representing 79.1  % (303, 481) of births. Hospitals that did not stock @entity7 had less annual births and were located a further distance from a center that provided pediatric cardiac surgical services. @entity0 born at a hospital that did not stock @entity7 had significantly greater serum @entity4 and @entity5 (p  =  0.002) and serum @entity4 on admission (p  <  0.001). The @entity7 availability was not associated with hospital length of stay, postoperative length of stay, or mortality. When stratifying in TGA and @entity6 subgroups, lack of @entity7 availability remained associated with higher @entity5 , higher @entity4 , lower @entity3 , and lower pH. @entity7 is not universally available in all healthcare institutions providing obstetrical services. Lack of availability of @entity7 at an outlying hospital was associated with increased morbidity, but was not associated with mortality or length of stay.

title: Prostaglandin Availability and Association with Outcomes for @entity0 with XXXX .

answer: @entity2


abstract: UNASSIGNED: Data regarding availability of @entity8 ( @entity7 ) and its impact on the stabilization, transport, critical care course, and surgical outcome of @entity0 with ductal-dependent @entity2 in the current pediatric healthcare environment are unknown. We sought to determine the proportion of hospitals in Texas that stock @entity7 and to investigate associations between @entity7 availability and clinical outcomes. All birth institutions listed with the Texas Department of Health and @entity0 Services were contacted to determine @entity7 availability as of 2011. Outcomes of all @entity0 admitted to our institution from 2007 to 2012 who received @entity7 for @entity1 were evaluated. @entity7 was stocked in 50  % (n  =  139) of hospitals that performed deliveries in Texas in 2011 representing 79.1  % (303, 481) of births. Hospitals that did not stock @entity7 had less annual births and were located a further distance from a center that provided pediatric cardiac surgical services. @entity0 born at a hospital that did not stock @entity7 had significantly greater serum @entity4 and @entity5 (p  =  0.002) and serum @entity4 on admission (p  <  0.001). The @entity7 availability was not associated with hospital length of stay, postoperative length of stay, or mortality. When stratifying in TGA and @entity6 subgroups, lack of @entity7 availability remained associated with higher @entity5 , higher @entity4 , lower @entity3 , and lower pH. @entity7 is not universally available in all healthcare institutions providing obstetrical services. Lack of availability of @entity7 at an outlying hospital was associated with increased morbidity, but was not associated with mortality or length of stay.

title: Prostaglandin Availability and Association with Outcomes for XXXX with @entity2 .

answer: @entity0


abstract: UNASSIGNED: @entity4 is considered to be one of the most @entity2 in the world. Severity of the disease between males and females is very important in clinical research areas. In this study, we investigated the impact of sex differences in brain response to @entity3 with @entity11 . Male and female C57Bl/6 @entity0 were infected with @entity11 -infected erythrocytes. The @entity3 induced a significant change in weight loss in males (-7.2  %        0.5) than females (-4.9  %        0.6). The maximum @entity12 reached about 15  % at day 9 postinfection. Also, @entity11 @entity3 caused histopathological changes in the brain of @entity0 . These changes were in the form of @entity1 , @entity5 , and structural changes in Purkinje cells. In addition, @entity11 was able to induce a marked oxidative damage in @entity0 brain. The @entity3 induced a significant increase in male brain @entity10 than females while the brain catalase level was significantly increased in infected females than infected males. Moreover, the change in brain neurotransmitters, @entity7 , @entity9 , @entity8 , and @entity6 , was more in infected males than infected females. At the molecular level, @entity11 was able to induce upregulations of Adam23, Cabp1, Cacnb4, Glrb, and Vdac3-mRNA in the brain of @entity0 . These genes were significantly upregulated in infected males than in infected females. In general, @entity11 could induce structural, biochemical, and molecular alterations in @entity0 brain. Severity of these alterations was different according to sex of @entity0 .

title: Impact of sex differences in brain response to @entity3 with XXXX .

answer: @entity11


abstract: UNASSIGNED: @entity4 is considered to be one of the most @entity2 in the world. Severity of the disease between males and females is very important in clinical research areas. In this study, we investigated the impact of sex differences in brain response to @entity3 with @entity11 . Male and female C57Bl/6 @entity0 were infected with @entity11 -infected erythrocytes. The @entity3 induced a significant change in weight loss in males (-7.2  %        0.5) than females (-4.9  %        0.6). The maximum @entity12 reached about 15  % at day 9 postinfection. Also, @entity11 @entity3 caused histopathological changes in the brain of @entity0 . These changes were in the form of @entity1 , @entity5 , and structural changes in Purkinje cells. In addition, @entity11 was able to induce a marked oxidative damage in @entity0 brain. The @entity3 induced a significant increase in male brain @entity10 than females while the brain catalase level was significantly increased in infected females than infected males. Moreover, the change in brain neurotransmitters, @entity7 , @entity9 , @entity8 , and @entity6 , was more in infected males than infected females. At the molecular level, @entity11 was able to induce upregulations of Adam23, Cabp1, Cacnb4, Glrb, and Vdac3-mRNA in the brain of @entity0 . These genes were significantly upregulated in infected males than in infected females. In general, @entity11 could induce structural, biochemical, and molecular alterations in @entity0 brain. Severity of these alterations was different according to sex of @entity0 .

title: Impact of sex differences in brain response to XXXX with @entity11 .

answer: @entity3


abstract: PURPOSE: @entity2 ( @entity2 ) are rare @entity1 that occur in @entity0 aged between 1 and 24  months. The @entity1 in general has a favorable prognosis after surgical resection. There are no treatment algorithms, however, for @entity0 with multiple intracranial and intraspinal presentations. CASE REPORT: In an 11-month-old @entity0 with a history of nystagmus, magnetic resonance imaging (MRI) demonstrated contrast-enhancing lesions in the suprasellar region, the cerebellar vermis, and the spinal axis. The @entity1 in the cerebellar vermis was removed via a suboccipital midline approach. The histological examination revealed a @entity5 ( @entity5 ) WHO grade I. Postoperatively, it was decided to adopt a wait-and-see strategy. Further development, up to 16  months after surgery, was unremarkable. Follow-up MRI showed no recurrence of the @entity4 , mild progress of the @entity1 , and significant regression of the @entity1 . CONCLUSION: @entity5 is a rare mostly benign @entity3 found in @entity0 . The final diagnosis always relies on histology. Surgical resection is the recommended therapy for symptomatic @entity1 ; however, more experience is needed to develop treatment recommendations for multiple-site @entity1 .

title: XXXX with multiple intracranial and intraspinal localizations at presentation.

answer: @entity5


abstract: In the haploid genome of @entity0 there are two genes coding for the r-protein @entity3 . It is not known if they are located on the same chromosome. cDNA clones deriving from the transcripts of the two genes have been isolated from an oocyte messenger cDNA bank showing that they are both expressed. We have studied the structure of one of the @entity3 genes by Electron Microscopy, restriction mapping and sequencing. An allelic form of the @entity3 gene was also isolated. It contains a large deletion covering the 5' end region up to the middle of the third intron. The 5' end of the @entity0 @entity3 gene was compared to that of the corresponding gene in the closely related species @entity2 and found to be highly conserved. The @entity3 gene has multiple initiation sites, but the large majority of the transcripts start in the middle of a @entity1 tract not preceded by a canonical TATA box as in other eukaryotic housekeeping genes. The @entity0 L1 and @entity3 genes have a common decanucleotide in the first exon in the same position with regard to the initiator ATG which just precedes the first intron. The decanucleotide shows homology with the @entity0 18S rRNA.

title: Sequences coding for the ribosomal protein L14 in XXXX and @entity2 ; homologies in the 5' untranslated region are shared with other r-protein mRNAs.

answer: @entity0


abstract: In the haploid genome of @entity0 there are two genes coding for the r-protein @entity3 . It is not known if they are located on the same chromosome. cDNA clones deriving from the transcripts of the two genes have been isolated from an oocyte messenger cDNA bank showing that they are both expressed. We have studied the structure of one of the @entity3 genes by Electron Microscopy, restriction mapping and sequencing. An allelic form of the @entity3 gene was also isolated. It contains a large deletion covering the 5' end region up to the middle of the third intron. The 5' end of the @entity0 @entity3 gene was compared to that of the corresponding gene in the closely related species @entity2 and found to be highly conserved. The @entity3 gene has multiple initiation sites, but the large majority of the transcripts start in the middle of a @entity1 tract not preceded by a canonical TATA box as in other eukaryotic housekeeping genes. The @entity0 L1 and @entity3 genes have a common decanucleotide in the first exon in the same position with regard to the initiator ATG which just precedes the first intron. The decanucleotide shows homology with the @entity0 18S rRNA.

title: Sequences coding for the ribosomal protein L14 in @entity0 and XXXX ; homologies in the 5' untranslated region are shared with other r-protein mRNAs.

answer: @entity2


abstract: OBJECTIVE: @entity3 ( @entity3 ) is a life-threatening and morbid pathology. This study aimed to investigate the efficacy of an early thrombolysis procedure using a rotator thrombolysis device. METHODS: Sixty-seven @entity0 with acute proximal @entity3 were enrolled in the study. @entity0 ' data were recorded retrospectively. Initially, an infrarenal retrievable vena cava filter was placed through the femoral vein. Then, a rotator thrombolysis device and a thrombolytic agent injection were applied to the occluded segments of the deep veins by puncturing the popliteal vein. RESULTS: The identified reasons were @entity2 (43.3%), pregnancy (20.9%), undiagnosed (11.9%), major surgical operation (10.5%), immobilization (7.5%), and @entity1 (5.9%). Immediate total recanalization was conducted in all @entity0 , and the leg diameters returned to normal ranges in the early postoperative period. Hospital mortality or severe complications were not detected. CONCLUSION: New thrombolytic devices seem to reduce in-hospital mortality risks and may potentially decrease post-thrombotic morbidity.

title: Pharmacomechanical thrombolysis with a rotator thrombolysis device in iliofemoral XXXX .

answer: @entity3


abstract: Allergen immunotherapy results in protection against allergen challenge and in the production of allergen specific antibodies. We investigated the reaction to @entity2 sting exposure and its relationship to the subclass of IgG-antibodies produced. 23 @entity0 who had a history of @entity1 to @entity2 stings were given 2-5 years courses of venom immunotherapy. 19 individuals tolerated a sting challenge 1, 2, and 3 years after the start of treatment, and after immunotherapy was discontinued. Four @entity0 with persisting systemic reactions and 6 @entity2 keepers served as controls. All detectable IgG-antibodies were restricted to subclass 1 and 4. In successfully treated @entity0 the mean rise of IgG-subclass was 273%, and of IgG4 703%, compared to pretreatment levels. IgG4-antibodies were maintained at high levels in protected individuals when immunotherapy was discontinued. On the contrary, in non-protected individuals low IgG4-levels were observed. Specific IgG4-antibodies most closely reflect clinical protection from stings provided by immunotherapy or a repeated antigenic stimulation.

title: [The key role of IgG4 subclass antibodies in the development of protection against XXXX to insect stings].

answer: @entity1


abstract: A major challenge in @entity2 ( @entity1 ) control is early and accurate diagnosis of sputum smear negative @entity2 (SSN-PTB). The @entity0 with SSN-PTB have to wait for a longer period of time before receiving proper treatment than sputum smear positive @entity2 (SSP-PTB) @entity0 due to delay in diagnosis. The purpose of this study is to discover potential serum protein biomarkers for SSN-PTB. Surface-enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF MS) combined with weak cation exchange (WCX) magnetic beads was used to screen serum samples from SSN-PTB @entity0 (N = 66), SSP-PTB @entity0 (N = 49), and healthy volunteers (N = 80). The serum protein profiles were analyzed with Biomarker Wizard system. A classification model was established using Biomarker Pattern Software (BPS). Fifty-eight protein peaks were identified to exhibit significant differences between SSN-PTB, SSP-PTB and healthy control groups (P < 0.05), among which 6 peaks were found to be down-regulated, while 10 peaks were up-regulated gradually in the healthy control, SSN-PTB, and SSP-PTB groups. Twenty-three discriminating m/z peaks were detected between SSN-PTB @entity0 and healthy controls (P < 0.01, Fold >=  1.5). The classification tree combined with three protein peaks (2747.0, 4480.0, and 9410.1 Da) could distinguish SSN-PTB @entity0 from healthy controls with a sensitivity of 83.33% and a specificity of 82.50%. Early diagnosis of SSN-PTB disease is critical in order to reduce morbidity and mortality associated with @entity1 . The study will help to clarify the role of differential proteins in the pathogenesis of @entity1 .

title: Comparative proteomic analysis of serum diagnosis patterns of sputum smear-positive XXXX based on magnetic bead separation and mass spectrometry analysis.

answer: @entity2


abstract: BACKGROUND: The presence of @entity2 in the kidney is extremely rare. We report a case of @entity2 in @entity1 incidentally found in a malfunctioning kidney removed because of xanthogranulomatous @entity4 . CASE PRESENTATION: A 53-year-old Chinese premenopausal @entity0 presented with intermittent right flank @entity3 for many years. Imaging studies revealed a contracted non-functioning right kidney and a @entity5 . The contracted kidney was considered to have resulted from chronic @entity4 . The abscess was drained. The @entity0 subsequently underwent a right nephrectomy. Histology revealed @entity1 in addition to xanthogranulomatous @entity4 and a @entity5 . No evidence of @entity2 was identified at the pelvic site. The @entity0 was symptom-free after operation. CONCLUSION: Endometriosis is a common benign condition in @entity0 of reproductive age that is characterized by the presence of endometrial glands and stroma outside the uterine cavity, which affects either genital or extragenital sites. Involvement of the urinary tract is rare. Among the urinary tract @entity2 , only a few cases involve the kidney. @entity1 is difficult to diagnose; a final diagnosis relies on the pathohistologic findings. Treatment involves hormonal manipulation or a hysterectomy with bilateral salpingo-oophorectomy. Whether a nephrectomy required depends on the level of renal function. Although extremely rare, renal @entity2 should be part of the differential diagnostic spectrum when a contracted, @entity1 is present. Early diagnosis might have prevented an unnecessary nephrectomy in cases of uncomplicated renal @entity2 .

title: Endometriosis in a kidney with focal xanthogranulomatous XXXX and a @entity5 .

answer: @entity4


abstract: BACKGROUND: The presence of @entity2 in the kidney is extremely rare. We report a case of @entity2 in @entity1 incidentally found in a malfunctioning kidney removed because of xanthogranulomatous @entity4 . CASE PRESENTATION: A 53-year-old Chinese premenopausal @entity0 presented with intermittent right flank @entity3 for many years. Imaging studies revealed a contracted non-functioning right kidney and a @entity5 . The contracted kidney was considered to have resulted from chronic @entity4 . The abscess was drained. The @entity0 subsequently underwent a right nephrectomy. Histology revealed @entity1 in addition to xanthogranulomatous @entity4 and a @entity5 . No evidence of @entity2 was identified at the pelvic site. The @entity0 was symptom-free after operation. CONCLUSION: Endometriosis is a common benign condition in @entity0 of reproductive age that is characterized by the presence of endometrial glands and stroma outside the uterine cavity, which affects either genital or extragenital sites. Involvement of the urinary tract is rare. Among the urinary tract @entity2 , only a few cases involve the kidney. @entity1 is difficult to diagnose; a final diagnosis relies on the pathohistologic findings. Treatment involves hormonal manipulation or a hysterectomy with bilateral salpingo-oophorectomy. Whether a nephrectomy required depends on the level of renal function. Although extremely rare, renal @entity2 should be part of the differential diagnostic spectrum when a contracted, @entity1 is present. Early diagnosis might have prevented an unnecessary nephrectomy in cases of uncomplicated renal @entity2 .

title: Endometriosis in a kidney with focal xanthogranulomatous @entity4 and a XXXX .

answer: @entity5


abstract: Recent data indicate that the prevalence and incidence of @entity3 are high among the elderly, many of whom will have concomitant neurodegenerative, cerebrovascular, or @entity1 . The aim of this study is to evaluate the clinical characteristics of elderly @entity0 with @entity3 in China. We retrospectively reviewed the clinical records of 104 outpatients over 50 years of age (average: 63.8 years). The results showed that in the total 104 outpatients, 53 @entity0 and 51 @entity0 were studied. Twenty-seven (26.0%) @entity0 had @entity6 , and 15 (14.4%) @entity0 were considered cryptogenic. Sixty-two (59.6%) @entity0 had remote @entity3 . According to the known etiological factors, @entity2 (53.2%) is the most common underlying cause, followed by @entity5 (16.1%), primary or metastatic @entity1 (16.1%), and others (14.5%). The most common type of @entity4 in the group studied was partial @entity4 (51.9%), followed by generalized @entity4 (37.5%). Forty-three @entity0 (41.3%) were used combination medication and 61 @entity0 (58.7%) were used single medication. In conclusions, this study provides important data for clinical and research purposes in China. Further research is indicated to confirm the clinical findings of the elderly @entity0 with @entity3 by a larger epidemiological study.

title: Evaluation of clinical features of elderly XXXX in China.

answer: @entity3


abstract: @entity3 is an uncommon disorder of postero-medial proximal tibial physis. Blount described infantile and adolescent types. This study aims to describe using femur, @entity4 to treat infantile @entity3 . From May 1992 to May 2005, 7 @entity0 of @entity3 (3 males, 4 females) were included, whose age was range from 17 to 62 months. Femorotibial angle (FTA) was 31    6   (range from 27   to 41  ). Metaphyseal-diaphyseal angle (MDA) was 16    4   (range from 13   to 24  ). The femoral vara angle was 10    4   (range from 2   to 23  ). According to Langenskiold's classification, 3 @entity0 were in stage II, 7 @entity0 in stage III, and 2 @entity0 in stage IV. Five cases were affected bilateral and 2 unilaterally, treated by famur, @entity4 , and a hip spica cast were used for 6 weeks after operation. Results indicated that all @entity0 were followed up 3 to 16 years. FTA, MDA and femur diaphysis were measured, FTA was 2    7  valgus (from 4   vara to 13   valgus). MDA was 1    2  valgus (range from 0   to 12  ). Femoral diaphyseal angle was 1    3  valgus (range from 3   vara to 7   valgus). Six @entity0 could walk without any knee @entity2 , except for 1 @entity0 with @entity1 feels his left genu uncomfortable after long time stand or work. His MDA was 12  , and FAT was -4  . In conclusion, femur, @entity4 are useful for correction of @entity3 . Recurrence and complication are less than those reported for @entity3 .

title: Melt-metaphyseal and diphyseal osteotomy for correction of infantile XXXX : a long-term follow-up study.

answer: @entity3


abstract: This study aims to explore the mechanism of immunosuppressants combined with cord blood (IS + CBI) for severe @entity1 . Selecting 30 @entity0 with SAA and all treated with IS + @entity5 (newly diagnosed group). 23 @entity0 who were treated effectively (effective group) while 7 cases were treated invalidly (invalid group). Another 20 healthy individuals were selected as control group. To detect the expression levels of @entity2 , @entity4 and other cytokines by ELISA method in each group. To detect the engraftment of cord blood stem cells by using short tandem repeat-polymerase chain reaction (STR-PCR) method. 1. @entity2 , @entity4 and other cytokines expressions in newly diagnosed group were significantly higher than in the control group. 2. After 6 months, the level in effective group was significantly lower than pretherapy (P < 0.05).The level in invalid group had no obvious difference than pretherapy. 3. After 1 month and 3 months of treatment, a small amount of engraftment was found in effective group. After 6 months, implant rejection was showed. No effective engraftment was observed in invalid group. 1. @entity2 , @entity4 cells in SAA @entity0 increased which might positively correlated with the progression of @entity3 . During the treatment of IS + CBI, there is a bridging mechanism between the early stage of engraftment and the advanced stage of immunosuppressant adjustment. The first 3 months after treatment, it relies on the engraftment of cord blood stem cells to promote hematopoietic recovery and 3 months later, it relies on immunosuppressants to maintain normal hematopoietic function.

title: Mechanism of immunosuppressants combined with cord blood for severe XXXX .

answer: @entity1


abstract: OBJECTIVE: To compare the efficacy of diffusion-weighted (DW) magnetic resonance (MR) imaging and Doppler ultrasonography (US) by using quantitative markers in acute unilateral obstruction due to @entity1 . METHODS: This prospective study included 28 @entity0 with unilateral @entity2 and 18 healthy control subjects. In Doppler US and DW MR imaging, resistive index (RI) and apparent diffusion coefficient (ADC) values were measured respectively. The results were compared in @entity0 and in control subjects. Paired samples test, two-tailed unpaired Student's t test and Spearman analysis were performed for statistical analysis. RESULTS: The mean RI in the 28 obstructed kidneys was significantly higher than the mean RI in unobstructed kidneys and in control subjects (P < 0.05). The ADC of obstructed kidneys in the cortex was significantly lower than the ADC of the contralateral unobstructed kidneys (P < 0.05). The ADC of unobstructed kidneys was significantly higher than the ADC of control subjects in the cortex (P < 0.05). RI and ADC values yielded no significant correlation. CONCLUSION: Doppler US and DW MR imaging provide accurate and noninvasive diagnosis, Doppler US may be preferred as it is a more practical technique compared to DW MR imaging in the evaluation of acute @entity2 due to @entity1 .

title: Diffusion-weighted MR imaging and Doppler ultrasonography in the evaluation of renal parenchyma in acute XXXX .

answer: @entity2


abstract: Enzymatic modification of @entity0 by nucleotidyltransferases, acetyltransferases and/or phosphotransferases accounts for the majority of @entity5 -resistant @entity4 isolates. In this study, we investigated the relationship between @entity5 resistance and the presence of @entity5 -modifying enzymes in @entity4 clinical isolate groups with different resistance profiles. Thirty-two clinical A. baumannii isolates were included in this study. @entity4 isolates were divided into 4 groups according to results of susceptibility testing. The presence of genes encoding the following @entity5 -modifying enzymes; aph (3')-V1, aph (3')-Ia, aac (3)-Ia, aac (3) IIa, aac (6')-Ih, aac (6')-Ib and ant (2')-Ia responsible for resistance was investigated by PCR in all strains. The acetyltransferase (aac (6')-Ib, aac (3)-Ia) and phosphotransferase (aph (3')-Ia) gene regions were identified in the first group, which comprised nine @entity3 , @entity2 , and @entity1 -resistant isolates. The acetyltransferase (aac (6')-Ib, aac (3)-Ia), phosphotransferase (aph (3')-VI) and nucleotidyltransferase (ant2-Ia) gene regions were identified in the second group, which was composed of nine @entity3 -resistant, @entity2 -resistant and @entity1 -sensitive isolates. The acetyltransferase (aac (3)-Ia) and phosphotransferase (aph (3')-Ia) regions were identified in the fourth group, which comprised eight @entity3 -sensitive, @entity2 -sensitive and @entity1 -resistant isolates. Modifying enzyme gene regions were not detected in the third group, which was composed of six @entity3 , @entity2 and @entity1 -sensitive isolates. Our data are consistent with previous reports, with the exception of four isolates. Both acetyltransferases and phosphotransferases were widespread in A. baumannii clinical isolates in our study. However, the presence of the enzyme alone is insufficient to explain the resistance rates. Therefore, the association between the development of resistance and the presence of the enzyme and other components should be investigated further.

title: Modifying enzymes related @entity5 : analyses of resistant XXXX isolates.

answer: @entity4


abstract: Enzymatic modification of @entity0 by nucleotidyltransferases, acetyltransferases and/or phosphotransferases accounts for the majority of @entity5 -resistant @entity4 isolates. In this study, we investigated the relationship between @entity5 resistance and the presence of @entity5 -modifying enzymes in @entity4 clinical isolate groups with different resistance profiles. Thirty-two clinical A. baumannii isolates were included in this study. @entity4 isolates were divided into 4 groups according to results of susceptibility testing. The presence of genes encoding the following @entity5 -modifying enzymes; aph (3')-V1, aph (3')-Ia, aac (3)-Ia, aac (3) IIa, aac (6')-Ih, aac (6')-Ib and ant (2')-Ia responsible for resistance was investigated by PCR in all strains. The acetyltransferase (aac (6')-Ib, aac (3)-Ia) and phosphotransferase (aph (3')-Ia) gene regions were identified in the first group, which comprised nine @entity3 , @entity2 , and @entity1 -resistant isolates. The acetyltransferase (aac (6')-Ib, aac (3)-Ia), phosphotransferase (aph (3')-VI) and nucleotidyltransferase (ant2-Ia) gene regions were identified in the second group, which was composed of nine @entity3 -resistant, @entity2 -resistant and @entity1 -sensitive isolates. The acetyltransferase (aac (3)-Ia) and phosphotransferase (aph (3')-Ia) regions were identified in the fourth group, which comprised eight @entity3 -sensitive, @entity2 -sensitive and @entity1 -resistant isolates. Modifying enzyme gene regions were not detected in the third group, which was composed of six @entity3 , @entity2 and @entity1 -sensitive isolates. Our data are consistent with previous reports, with the exception of four isolates. Both acetyltransferases and phosphotransferases were widespread in A. baumannii clinical isolates in our study. However, the presence of the enzyme alone is insufficient to explain the resistance rates. Therefore, the association between the development of resistance and the presence of the enzyme and other components should be investigated further.

title: Modifying enzymes related XXXX : analyses of resistant @entity4 isolates.

answer: @entity5


abstract: This case report describes the symptoms and clinical course of a 35-year-old female @entity0 who was diagnosed with a temporo-sphenoidal encephalocele. It is characterized by herniation of cerebral tissue of the temporal lobe through a defect of the skull base localized in the middle fossa. At the time of first presentation the @entity0 complained about recurrent nasal discharge of clear fluid which had begun some weeks earlier. She also reported that three months earlier she had for the first time suffered from a generalized @entity1 . In a first therapeutic attempt an endoscopic endonasal approach to the sphenoid sinus was performed. An attempt to randomly seal the suspicious area failed. After frontotemporal craniotomy, it was possible to localize the encephalocele and the underlying bone defect. The herniated brain tissue was resected and the dural defect was closed with fascia of the temporalis muscle. In summary, the combination of recurrent @entity2 and a first-time @entity1 should alert specialists of otolaryngology, neurology and neurosurgery of a temporo-sphenoidal encephalocele as a possible cause. Treatment is likely to require a neurosurgical approach.

title: @entity2 and XXXX caused by temporo-sphenoidal encephalocele.

answer: @entity1


abstract: This case report describes the symptoms and clinical course of a 35-year-old female @entity0 who was diagnosed with a temporo-sphenoidal encephalocele. It is characterized by herniation of cerebral tissue of the temporal lobe through a defect of the skull base localized in the middle fossa. At the time of first presentation the @entity0 complained about recurrent nasal discharge of clear fluid which had begun some weeks earlier. She also reported that three months earlier she had for the first time suffered from a generalized @entity1 . In a first therapeutic attempt an endoscopic endonasal approach to the sphenoid sinus was performed. An attempt to randomly seal the suspicious area failed. After frontotemporal craniotomy, it was possible to localize the encephalocele and the underlying bone defect. The herniated brain tissue was resected and the dural defect was closed with fascia of the temporalis muscle. In summary, the combination of recurrent @entity2 and a first-time @entity1 should alert specialists of otolaryngology, neurology and neurosurgery of a temporo-sphenoidal encephalocele as a possible cause. Treatment is likely to require a neurosurgical approach.

title: XXXX and @entity1 caused by temporo-sphenoidal encephalocele.

answer: @entity2


abstract: UNASSIGNED: @entity2 is a principal motivator of @entity0 molestation, incurring great emotional and financial burdens on victims and society. Even among pedophiles who never commit any offense, the condition requires lifelong suppression and control. Previous comparison using voxel-based morphometry (VBM) of MR images from a large sample of pedophiles and controls revealed group differences in white matter. The present study therefore sought to verify and characterize white matter involvement using diffusion tensor imaging (DTI), which better captures the microstructure of white matter than does VBM. Pedophilic sex offenders (n  =  24) were compared with healthy, age-matched controls with no criminal record and no indication of @entity2 (n  =  32). White matter microstructure was analyzed with Tract-Based Spatial Statistics, and the trajectories of implicated fiber bundles were identified by probabilistic tractography. Groups showed significant, highly focused differences in DTI parameters which related to @entity0 ' genital responses to sexual depictions of @entity0 , but not to measures of psychopathy or to childhood histories of physical @entity1 , or neglect. Some previously reported gray matter differences were suggested under highly liberal statistical conditions (p uncorrected  <  .005), but did not survive ordinary statistical correction (whole brain per voxel false discovery rate of 5  %). These results confirm that @entity2 is characterized by neuroanatomical differences in white matter microstructure, over and above any neural characteristics attributable to psychopathy and childhood adversity, which show neuroanatomic footprints of their own. Although some gray matter structures were implicated previously, only few have emerged reliably.

title: Diffusion Tensor Imaging of XXXX .

answer: @entity2


abstract: INTRODUCTION: @entity3 is one cause of posterior reversible @entity2 syndrome. @entity3 and @entity4 have only been reported in a few individual case reports. CASE DESCRIPTION: A 51-year-old @entity0 presented with @entity3 @entity2 . T2-weighted images from magnetic resonance imaging showed hyperintense lesions in both occipital and parietal lobes. Diffusion-weighted imaging showed that this represented cytotoxic @entity1 and perfusion magnetic resonance imaging revealed reduced blood volume and flow. The magnetic resonance imaging was repeated 5 months later and subtotal regression of theT2-hyperintensity had occurred. However, small bilateral @entity5 were seen on T1-weighted images. Perfusion magnetic resonance imaging presented reduced blood volume and flow on the right side. DISCUSSION AND EVALUATION: The @entity0 in this report had posterior reversible @entity2 syndrome caused by @entity3 @entity2 . Magnetic resonance imaging of the brain showed bilateral cytotoxic @entity1 that partially resolved and resulted in small @entity5 . The imaging findings are compatible with posterior reversible @entity2 syndrome with subtotal resolution and @entity5 evolution. CONCLUSION: The case report suggests that the presence of @entity3 @entity2 and posterior reversible @entity2 syndrome should alert clinicians and lead to prompt treatment in order to prevent @entity2 .

title: XXXX and @entity4 .

answer: @entity3


abstract: INTRODUCTION: @entity3 is one cause of posterior reversible @entity2 syndrome. @entity3 and @entity4 have only been reported in a few individual case reports. CASE DESCRIPTION: A 51-year-old @entity0 presented with @entity3 @entity2 . T2-weighted images from magnetic resonance imaging showed hyperintense lesions in both occipital and parietal lobes. Diffusion-weighted imaging showed that this represented cytotoxic @entity1 and perfusion magnetic resonance imaging revealed reduced blood volume and flow. The magnetic resonance imaging was repeated 5 months later and subtotal regression of theT2-hyperintensity had occurred. However, small bilateral @entity5 were seen on T1-weighted images. Perfusion magnetic resonance imaging presented reduced blood volume and flow on the right side. DISCUSSION AND EVALUATION: The @entity0 in this report had posterior reversible @entity2 syndrome caused by @entity3 @entity2 . Magnetic resonance imaging of the brain showed bilateral cytotoxic @entity1 that partially resolved and resulted in small @entity5 . The imaging findings are compatible with posterior reversible @entity2 syndrome with subtotal resolution and @entity5 evolution. CONCLUSION: The case report suggests that the presence of @entity3 @entity2 and posterior reversible @entity2 syndrome should alert clinicians and lead to prompt treatment in order to prevent @entity2 .

title: @entity3 and XXXX .

answer: @entity4


abstract: UNASSIGNED: Endovascular treatment for superior sagittal sinus (SSS) @entity3 is not always successful because of difficult access and @entity2 . We report the first two cases of @entity0 with @entity1 at the SSS that was not recanalized by anticoagulation, mechanical thrombectomy, or thrombolysis, but was successfully treated by stent placement. Case 1 was a 37-year-old @entity0 with bilateral @entity5 . Digital subtraction angiography showed obstruction of the sinus from the SSS to the right transverse sinus. Recanalization was achieved by selective thrombolysis using urokinase followed by balloon angioplasty, but re-occlusion occurred on the next day of treatment. Repeated endovascular treatment including balloon angioplasty, @entity3 aspiration and thrombolysis using recombinant tissue plasminogen activator failed to achieve recanalization. We thus placed intracranial stents in the SSS, which did achieve recanalization. Case 2 was a 69-year-old @entity0 with a small @entity4 in the left parietal lobe. Digital subtraction angiography showed @entity1 from the SSS to the bilateral transverse sinuses. Recanalization was not achieved by balloon angioplasty, @entity3 aspiration and selective thrombolysis. We thus placed intracranial stents in the SSS, which did achieve recanalization. Postoperative course was uneventful in both cases and venous sinus patency was confirmed by venography >1.5 years after treatment. When conventional endovascular strategies have been unsuccessful, placement of intracranial stents, which can easily gain access to the distal part of the SSS as compared with carotid stents, may be a useful treatment option for the acute sinus @entity3 in this region.

title: Stenting for XXXX in the superior sagittal sinus.

answer: @entity1


abstract: BACKGROUND: The Functioning Assessment Short Test (FAST) was developed for the clinical evaluation of functional impairment of @entity0 suffering from @entity1 . The aim of this study was to validate the Finnish version of FAST. METHODS: Translation and back-translation of FAST were performed. Fifty @entity0 with the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (DSM-IV) bipolar type I and II were interviewed at the @entity1 Research and Treatment Centre, City of Helsinki, Finland. @entity0 completed the FAST, the Social and Occupational Functioning Assessment Scale (SOFAS) of DSM-IV, and the Sheehan Disability Scale (SDS) as part of the assessment. Internal consistency and correlations between FAST and SOFAS and SDS were analysed. Twenty-five @entity0 participated in a reliability assessment carried out 1 week apart by a different rater. RESULTS AND DISCUSSION: The internal consistency coefficient obtained was very good, with a Cronbach alpha of 0.870. Reliability of FAST was also found excellent (correlation between two measures r   =   0.896, p   <   0.001). A highly significant negative correlation between FAST and SOFAS scores was found (r   =   -0.723, p   <   0.001). FAST and SDS were also highly significantly correlated (r   =   0.742, p   <   0.001). CONCLUSIONS: The psychometric validity and reliability of FAST in the Finnish sample of @entity0 with @entity1 types I and II were good.

title: Validity and reliability of the Finnish version of the Functioning Assessment Short Test (FAST) in XXXX .

answer: @entity1


abstract: BACKGROUND: @entity6 ( @entity6 ) or @entity9 is a severe complication of advanced @entity7 ( @entity7 ) and dialysis. Few effective treatments are available and the mortality rate is high. We report 4 cases in which @entity10 therapy was rapidly effective. CASES: @entity10 therapy was given to 4 Caucasian @entity0 (3 females and 1 male aged 49 to 91 years) with @entity6 . The causes of end-stage @entity7 were nephroangiosclerosis (n=2) and @entity8 (n=2). The lesions developed 1 to 6.5 years after the initiation of hemodialysis and involved the lower limbs in 2 @entity0 , the fingers in 1 @entity0 , and a breast in the remaining @entity0 . They were responsible for @entity3 and @entity1 in all 4 @entity0 . Local superinfection occurred in 3 @entity0 . Intravenous @entity10 was given in a dosage of 12.5 to 25g after each hemodialysis session, for 12 to 24 weeks. The @entity3 and @entity2 resolved fully in all 4 @entity0 . The side effects consisted of @entity4 and @entity5 (n=2) and a moderate blood pressure decrease (n=1). No recurrences were noted during the follow-up of 5 to 17 months after treatment discontinuation. CONCLUSION: The findings from this small case-series suggest that @entity10 may hold promise for the treatment of @entity6 .

title: XXXX is effective in @entity6 complicating chronic hemodialysis.

answer: @entity10


abstract: BACKGROUND: @entity6 ( @entity6 ) or @entity9 is a severe complication of advanced @entity7 ( @entity7 ) and dialysis. Few effective treatments are available and the mortality rate is high. We report 4 cases in which @entity10 therapy was rapidly effective. CASES: @entity10 therapy was given to 4 Caucasian @entity0 (3 females and 1 male aged 49 to 91 years) with @entity6 . The causes of end-stage @entity7 were nephroangiosclerosis (n=2) and @entity8 (n=2). The lesions developed 1 to 6.5 years after the initiation of hemodialysis and involved the lower limbs in 2 @entity0 , the fingers in 1 @entity0 , and a breast in the remaining @entity0 . They were responsible for @entity3 and @entity1 in all 4 @entity0 . Local superinfection occurred in 3 @entity0 . Intravenous @entity10 was given in a dosage of 12.5 to 25g after each hemodialysis session, for 12 to 24 weeks. The @entity3 and @entity2 resolved fully in all 4 @entity0 . The side effects consisted of @entity4 and @entity5 (n=2) and a moderate blood pressure decrease (n=1). No recurrences were noted during the follow-up of 5 to 17 months after treatment discontinuation. CONCLUSION: The findings from this small case-series suggest that @entity10 may hold promise for the treatment of @entity6 .

title: @entity10 is effective in XXXX complicating chronic hemodialysis.

answer: @entity6


abstract: A report is given of 87 pregnancies in hyperprolactinaemic @entity0 treated with @entity4 . The high @entity5 level in 11 cases was caused by hypophyseal @entity2 . If the plasma @entity5 level exceeded 5000 mU/l during pregnancy, @entity4 was administered until delivery. If the initial @entity5 value was over 1000 mU/l, the @entity5 level was measured during pregnancy, delivery and the lactational period. After weaning, the @entity5 level was again elevated in the majority of cases. During pregnancy, delivery and lactation, complications which differed significantly from the usual were not observed, pregnancy and nursing took place normally. Breast feeding was not contraindicated in any of the cases. Among the newborns, adaptation disturbances and @entity1 , showed the usual frequency. In the authors' opinion pregnancies which occur during the treatment of hyperprolactinaemic @entity0 need increased care. Complications during pregnancy, delivery and nursing period were not more frequently observed either in the mother or the newborn. The @entity3 did not deteriorate during gestation and lactation, but its normalization can not be expected.

title: Pregnancy, delivery and lactation in hyperprolactinaemic XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity1 pose a growing epidemiological and health problem worldwide. @entity2 are the leading cause of @entity4 among @entity0 with @entity10 . Increased risk of @entity9 in these @entity0 results from the occurrence of traditional and non-traditional risk factors. The aim of this study was to assess the relationship between selected risk factors for @entity2 (age, sex, @entity11 , @entity3 , etc.), intima-media thickness and coronary artery @entity6 score in @entity0 with @entity10 stages 2, 3 and 4. This study included 60 @entity0 with @entity10 divided into 3 groups on the basis of disease stage and control group consisting of 20 individuals without diagnosed @entity10 and @entity2 . Blood analysis and blood pressure measurements were taken. All @entity0 underwent carotid artery ultrasound with the assessment of the intima-media thickness, and heart CT scan in order to assess the index of @entity7 . Logistic regression analysis revealed statistically significant correlation between blood vessels @entity8 and age-the increase in age by 1  year was associated with the increase in the risk of @entity7 by 6.7  %. The increase in IMT by about 0.1  mm raises the risk of @entity8 by about 2  %. Second logistic regression model revealed that one-year increase in age was associated with an increase in the risk of intima-media thickening by 6.5  %. Occurrence of @entity3 was associated with a ninefold increase in intima-media thickening risk in comparison with @entity0 with normal blood pressure. To sum up, age and @entity3 were associated with the growth of IMT in CKD @entity0 , while age and exposure to @entity5 smoke were associated with the increase in coronary artery @entity6 score. The relationship between thickening of IMT and the increase in @entity8 index in @entity0 was also observed in study group.

title: Assessment of the relationship between selected cardiovascular risk factors and the indices of intima-media thickness and coronary artery @entity6 score in various stages of XXXX .

answer: @entity10


abstract: UNASSIGNED: @entity1 pose a growing epidemiological and health problem worldwide. @entity2 are the leading cause of @entity4 among @entity0 with @entity10 . Increased risk of @entity9 in these @entity0 results from the occurrence of traditional and non-traditional risk factors. The aim of this study was to assess the relationship between selected risk factors for @entity2 (age, sex, @entity11 , @entity3 , etc.), intima-media thickness and coronary artery @entity6 score in @entity0 with @entity10 stages 2, 3 and 4. This study included 60 @entity0 with @entity10 divided into 3 groups on the basis of disease stage and control group consisting of 20 individuals without diagnosed @entity10 and @entity2 . Blood analysis and blood pressure measurements were taken. All @entity0 underwent carotid artery ultrasound with the assessment of the intima-media thickness, and heart CT scan in order to assess the index of @entity7 . Logistic regression analysis revealed statistically significant correlation between blood vessels @entity8 and age-the increase in age by 1  year was associated with the increase in the risk of @entity7 by 6.7  %. The increase in IMT by about 0.1  mm raises the risk of @entity8 by about 2  %. Second logistic regression model revealed that one-year increase in age was associated with an increase in the risk of intima-media thickening by 6.5  %. Occurrence of @entity3 was associated with a ninefold increase in intima-media thickening risk in comparison with @entity0 with normal blood pressure. To sum up, age and @entity3 were associated with the growth of IMT in CKD @entity0 , while age and exposure to @entity5 smoke were associated with the increase in coronary artery @entity6 score. The relationship between thickening of IMT and the increase in @entity8 index in @entity0 was also observed in study group.

title: Assessment of the relationship between selected cardiovascular risk factors and the indices of intima-media thickness and coronary artery XXXX score in various stages of @entity10 .

answer: @entity6


abstract: In the paper presented here the following parameters on the skin of pure-bred @entity0 inbred @entity0 were investigated during the early postnatal maturation period: DNA-content (according to Burton 1956), @entity1 -content (according to Strauch 1965), beta-glucuronidase activity (according to Fishman 1974), partly also protein-content (according to Lowry 1951). At the same time, we tested if a single i.p. injection of @entity2 , applied exactly at the same time of the day 24 h preceding the killing, has an influence on the above mentioned quantities in comparison to the control group (possibly dosage-dependent). In the observation period (2nd, 4th, 6th, 9th, and 14th day) a linear, statistically significant increase of the @entity1 -content could be stated on the skin. After an initial increase up to the 4th day of life the DNA-content significantly decreases during the following postnatal maturation period until the 14th day. These results could be obtained both in the control groups, and in the animals treated with different dosages of @entity2 . It is of importance that these parameters (especially the cell and the DNA-content respectively) were not statistically significantly changed by pretreatment with the glucocorticoid at any day investigated. The total activity of the further tested lysosomal indicator-enzyme beta-glucuronidase increases during the postnatal maturation period up to its maximum on the 9th day of life before it decreases till the 14th day. The applied dosages of the glucucorticoid led to a general increase of the enzyme activity, which, however, was only exceptionally statistically significant. This enzyme induction could also by discussed in terms of a maturation acceleration. Dosage-dependent differences could partly be demonstrated.

title: [The influence of a single glucocorticoid administration on the DNA and the XXXX -content as well as on the beta-glucuronidase activity of @entity0 skin during postnatal development (author's transl)].

answer: @entity1


abstract: In the paper presented here the following parameters on the skin of pure-bred @entity0 inbred @entity0 were investigated during the early postnatal maturation period: DNA-content (according to Burton 1956), @entity1 -content (according to Strauch 1965), beta-glucuronidase activity (according to Fishman 1974), partly also protein-content (according to Lowry 1951). At the same time, we tested if a single i.p. injection of @entity2 , applied exactly at the same time of the day 24 h preceding the killing, has an influence on the above mentioned quantities in comparison to the control group (possibly dosage-dependent). In the observation period (2nd, 4th, 6th, 9th, and 14th day) a linear, statistically significant increase of the @entity1 -content could be stated on the skin. After an initial increase up to the 4th day of life the DNA-content significantly decreases during the following postnatal maturation period until the 14th day. These results could be obtained both in the control groups, and in the animals treated with different dosages of @entity2 . It is of importance that these parameters (especially the cell and the DNA-content respectively) were not statistically significantly changed by pretreatment with the glucocorticoid at any day investigated. The total activity of the further tested lysosomal indicator-enzyme beta-glucuronidase increases during the postnatal maturation period up to its maximum on the 9th day of life before it decreases till the 14th day. The applied dosages of the glucucorticoid led to a general increase of the enzyme activity, which, however, was only exceptionally statistically significant. This enzyme induction could also by discussed in terms of a maturation acceleration. Dosage-dependent differences could partly be demonstrated.

title: [The influence of a single glucocorticoid administration on the DNA and the @entity1 -content as well as on the beta-glucuronidase activity of XXXX skin during postnatal development (author's transl)].

answer: @entity0


abstract: Environmental standards for @entity3 ( @entity4 , @entity3 ) are currently being considered by regulatory agencies worldwide. Among these are limits for tap water, soil at industrial sites, residential soil, fish, ambient air, and @entity2 ash. Thus far, in the United States, no standards have been promulgated but a few have been suggested. This paper critically evaluates several aspects of previously proposed approaches to setting limits for @entity3 in residential soil and soil within industrial sites. Factors and assumptions which significantly affect the predicted degree of hazard associated with exposure to soil contaminated with low levels of @entity4 are discussed. This paper shows how different, more justifiable assumptions than those used by the Centers for Disease Control (CDC) regarding the quantities of soil typically consumed by @entity0 , @entity3 's nongenotoxicity, dermal exposure to soil, the concentration of airborne soil particles, @entity4 's bioavailability in soil, and extrapolation of the dose response curve can profoundly affect the results of the risk assessment and, subsequently, the magnitude of the recommended limits. Two case studies which quantitatively illustrate the effect of these assumptions on the risk estimates are presented. Non-U.S. regulatory agencies have considered @entity3 's nongenotoxicity in estimating that the virtually safe dose (VSD) or acceptable daily dose for @entity4 is approximately 10 pg/kg/day (10,000 fg/kg/day). These approaches are compared and contrasted with the method used by the United States EPA whose risk estimates are higher and whose VSD is approximately 1,000-fold lower. Alternative approaches to interpreting the @entity1 data indicate that a VSD of 130 pg/kg/day is more scientifically justified than risks estimated using standard approaches. This assessment indicates that a soil concentration of @entity3 considerably in excess of 1 ppb should be acceptable for residential and nonresidential areas.

title: A critical examination of assumptions used in risk assessments of XXXX contaminated soil.

answer: @entity4


abstract: In @entity2 ( @entity2 ), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with @entity3 , is evident in distinct brain regions. Staging of tau pathology by postmortem analysis of @entity2 subjects suggests a sequence of initiation and subsequent spread of neurofibrillary tau tangles along defined brain anatomical pathways. Further, the severity of @entity1 correlates with the degree and extent of tau pathology. In this study, we demonstrate that phospho-tau (p-tau) antibodies, @entity8 and @entity7 , can prevent the induction of tau pathology in primary neuron cultures. The impact of passive immunotherapy on the formation and spread of tau pathology, as well as functional deficits, was subsequently evaluated with these antibodies in two distinct transgenic @entity0 @entity4 models. The rTg4510 transgenic @entity0 is characterized by inducible over-expression of @entity5 mutant tau, and exhibits robust age-dependent brain tau pathology. Systemic treatment with @entity8 and @entity7 from 3 to 6 months of age led to a significant decline in brain and CSF p-tau levels. In a second model, injection of preformed tau fibrils (PFFs) comprised of recombinant tau protein encompassing the microtubule-repeat domains into the cortex and hippocampus of young @entity6 mutant tau over-expressing @entity0 (PS19) led to robust tau pathology on the ipsilateral side with evidence of spread to distant sites, including the contralateral hippocampus and bilateral entorhinal cortex 4 weeks post-injection. Systemic treatment with @entity7 led to a significant decline in the spread of tau pathology in this model. The reduction in tau species after p-tau antibody treatment was associated with an improvement in novel-object recognition memory test in both models. These studies provide evidence supporting the use of tau immunotherapy as a potential treatment option for @entity2 and other @entity4 .

title: Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct @entity0 XXXX models.

answer: @entity4


abstract: In @entity2 ( @entity2 ), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with @entity3 , is evident in distinct brain regions. Staging of tau pathology by postmortem analysis of @entity2 subjects suggests a sequence of initiation and subsequent spread of neurofibrillary tau tangles along defined brain anatomical pathways. Further, the severity of @entity1 correlates with the degree and extent of tau pathology. In this study, we demonstrate that phospho-tau (p-tau) antibodies, @entity8 and @entity7 , can prevent the induction of tau pathology in primary neuron cultures. The impact of passive immunotherapy on the formation and spread of tau pathology, as well as functional deficits, was subsequently evaluated with these antibodies in two distinct transgenic @entity0 @entity4 models. The rTg4510 transgenic @entity0 is characterized by inducible over-expression of @entity5 mutant tau, and exhibits robust age-dependent brain tau pathology. Systemic treatment with @entity8 and @entity7 from 3 to 6 months of age led to a significant decline in brain and CSF p-tau levels. In a second model, injection of preformed tau fibrils (PFFs) comprised of recombinant tau protein encompassing the microtubule-repeat domains into the cortex and hippocampus of young @entity6 mutant tau over-expressing @entity0 (PS19) led to robust tau pathology on the ipsilateral side with evidence of spread to distant sites, including the contralateral hippocampus and bilateral entorhinal cortex 4 weeks post-injection. Systemic treatment with @entity7 led to a significant decline in the spread of tau pathology in this model. The reduction in tau species after p-tau antibody treatment was associated with an improvement in novel-object recognition memory test in both models. These studies provide evidence supporting the use of tau immunotherapy as a potential treatment option for @entity2 and other @entity4 .

title: Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct XXXX @entity4 models.

answer: @entity0


abstract: OBJECTIVE: Variants in @entity6 are associated with Lewy Body (LB) pathology. We investigated whether variants in other @entity2 ( @entity2 ) genes also contribute to disease pathogenesis. METHODS: We performed a genetic analysis of four @entity2 genes including @entity6 , @entity4 , @entity9 , and @entity8 in 231 brain autopsies. Brain autopsies included neuropathologically defined @entity7 without @entity0 ( @entity0 ) changes (n = 59), @entity0 without significant LB pathology (n = 71), @entity0 and lewy body variant (ADLBV) (n = 68), and control brains without LB or @entity0 neuropathology (n = 33). Sequencing of @entity4 , @entity9 , @entity8 and @entity6 followed by 'gene wise' genetic association analysis was performed. To determine the functional effect, a biochemical analysis of @entity6 in a subset of brains was also performed. GCase activity was measured in a subset of brain samples (n = 64) that included @entity7 brains, with or without @entity6 mutations, and control brains. A lipidomic analysis was also performed in brain autopsies (n = 67) which included @entity7 (n = 34), ADLBV (n = 3), @entity0 (n = 4), @entity1 (n = 9) and control brains (n = 17), comparing @entity6 mutation carriers to non-carriers. RESULTS: In a 'gene-wise' analysis, variants in @entity6 , @entity9 and @entity8 were significantly associated with LB pathology (p range: 0.03-4.14 x10-5). Overall, the mean levels of GCase activity were significantly lower in @entity6 mutation carriers compared to non-carriers (p<0.001). A significant increase and accumulation of several species for the lipid classes, @entity3 and @entity5 , was observed in @entity7 brains carrying @entity6 mutations compared to controls (p range: p<0.05-p<0.01). INTERPRETATION: Our study indicates that variants in @entity6 , @entity9 and @entity8 are associated with LB pathology. Biochemical data comparing @entity6 mutation carrier to non-carriers support these findings, which have important implications for biomarker development and therapeutic strategies.

title: Gene-wise association of variants in four XXXX genes in neuropathologically confirmed lewy body disease.

answer: @entity2


abstract: Plants have evolved with intricate mechanisms to cope with multiple environmental stresses. To adapt with biotic and abiotic stresses, plant responses involve changes at the cellular and molecular levels. The current study was designed to investigate the effects of combinations of different environmental stresses on the transcriptome level of @entity1 genome using public microarray databases. We investigated the role of cyclopentenones in mediating plant responses to environmental stress through TGA (TGACG motif-binding factor) transcription factor, independently from jasmonic acid. Candidate genes were identified by comparing plants inoculated with @entity2 or treated with heat, salt or osmotic stress with non-inoculated or non-treated tissues. About 2.5% heat-, 19% salinity- and 41% osmotic stress-induced genes were commonly upregulated by @entity2 -treatment; and 7.6%, 19% and 48% of genes were commonly downregulated by @entity2 -treatment, respectively. Our results indicate that plant responses to biotic and abiotic stresses are mediated by several common regulatory genes. Comparisons between transcriptome data from @entity1 stressed-plants support our hypothesis that some molecular and biological processes involved in biotic and abiotic stress response are conserved. Thirteen of the common regulated genes to abiotic and biotic stresses were studied in detail to determine their role in plant resistance to @entity2 . Moreover, a T-DNA insertion mutant of the Responsive to Dehydration gene (rd20), encoding for a member of the caleosin (lipid surface protein) family, showed an enhanced sensitivity to @entity2 @entity0 and drought. Overall, the overlapping of plant responses to abiotic and biotic stresses, coupled with the sensitivity of the rd20 mutant, may provide new interesting programs for increased plant resistance to multiple environmental stresses, and ultimately increases its chances to survive. Future research directions towards a better dissection of the potential crosstalk between @entity2 , abiotic stress, and oxylipin signaling are of our particular interest.

title: Identification of XXXX candidate genes in response to biotic and abiotic stresses using comparative microarrays.

answer: @entity1


abstract: OBJECTIVE: Evidence suggests that an acute systemic inflammatory response is invoked after consumption of a high-energy meal. Postprandial regulation of @entity3 , an adipose tissue-derived, anti-inflammatory hormone, and the gelatinases, @entity4 and @entity5 , endopeptidases implicated in a diverse range of inflammatory processes, remain inconclusive. The aim of this study was to assess the postprandial effect of a high-energy (1212  kcal) meal on plasma @entity3 , @entity4 and @entity5 activity, @entity2 , insulin, @entity6 , total @entity1 , high-density lipoprotein @entity1 , and the differential effects on these parameters depending on whether the test meal was high fat (HF; 46  g fat, 1210  kcal) or isoenergetic and low fat (LF; 15  g fat, 1214  kcal energy). METHODS: Test meals were consumed by 17 lean, healthy @entity0 on two separate occasions with blood samples collected by venipuncture at baseline (0  h) and 1 and 3  h after consumption of each test meal. RESULTS: At baseline, no significant difference was seen in the parameters between the two groups, except for @entity4 , @entity5 , and total @entity1 . Over the 3-h postprandial period, no significant differential effect of the HF versus the LF test meal was observed on @entity3 , @entity4 , @entity5 , or on metabolic markers other than @entity6 , which increased significantly in response to the HF test meal (time  *  treatment, P  =  0.002). When analyzed independent of time, @entity4 (treatment, P  =  0.006), @entity5 (treatment, P  =  0.022), and @entity2 (treatment, P  =  0.026) were lower after consumption of the HF meal compared with the LF test meal. When analyzed independent of treatment, @entity3 increased over the 3-h postprandial period (time, P  =  0.031), but there was no change in @entity4 or @entity5 (time, P  =  0.503 and P  =  0.525, respectively). Over the 3-h postprandial period, insulin (time, P  <  0.001) and total @entity1 (time, P  =  0.002) increased, whereas @entity2 (time, P  <  0.001) and high-density lipoprotein @entity1 (time, P  <  0.001) decreased. CONCLUSION: No differential effects of a HF versus a LF isoenergetic meal were seen on postprandial @entity3 or the gelatinases. @entity3 increased in response to a high-energy meal independent of treatment, and the gelatinases were lower in response to the HF versus the LF isoenergetic meal, independent of time point. Given the considerable amount of time that @entity0 spend in the postprandial state, additional research is necessary to further understand inflammatory changes in this state.

title: Postprandial XXXX and gelatinase response to a high-fat versus an isoenergetic low-fat meal in lean, healthy @entity0 .

answer: @entity3


abstract: OBJECTIVE: Evidence suggests that an acute systemic inflammatory response is invoked after consumption of a high-energy meal. Postprandial regulation of @entity3 , an adipose tissue-derived, anti-inflammatory hormone, and the gelatinases, @entity4 and @entity5 , endopeptidases implicated in a diverse range of inflammatory processes, remain inconclusive. The aim of this study was to assess the postprandial effect of a high-energy (1212  kcal) meal on plasma @entity3 , @entity4 and @entity5 activity, @entity2 , insulin, @entity6 , total @entity1 , high-density lipoprotein @entity1 , and the differential effects on these parameters depending on whether the test meal was high fat (HF; 46  g fat, 1210  kcal) or isoenergetic and low fat (LF; 15  g fat, 1214  kcal energy). METHODS: Test meals were consumed by 17 lean, healthy @entity0 on two separate occasions with blood samples collected by venipuncture at baseline (0  h) and 1 and 3  h after consumption of each test meal. RESULTS: At baseline, no significant difference was seen in the parameters between the two groups, except for @entity4 , @entity5 , and total @entity1 . Over the 3-h postprandial period, no significant differential effect of the HF versus the LF test meal was observed on @entity3 , @entity4 , @entity5 , or on metabolic markers other than @entity6 , which increased significantly in response to the HF test meal (time  *  treatment, P  =  0.002). When analyzed independent of time, @entity4 (treatment, P  =  0.006), @entity5 (treatment, P  =  0.022), and @entity2 (treatment, P  =  0.026) were lower after consumption of the HF meal compared with the LF test meal. When analyzed independent of treatment, @entity3 increased over the 3-h postprandial period (time, P  =  0.031), but there was no change in @entity4 or @entity5 (time, P  =  0.503 and P  =  0.525, respectively). Over the 3-h postprandial period, insulin (time, P  <  0.001) and total @entity1 (time, P  =  0.002) increased, whereas @entity2 (time, P  <  0.001) and high-density lipoprotein @entity1 (time, P  <  0.001) decreased. CONCLUSION: No differential effects of a HF versus a LF isoenergetic meal were seen on postprandial @entity3 or the gelatinases. @entity3 increased in response to a high-energy meal independent of treatment, and the gelatinases were lower in response to the HF versus the LF isoenergetic meal, independent of time point. Given the considerable amount of time that @entity0 spend in the postprandial state, additional research is necessary to further understand inflammatory changes in this state.

title: Postprandial @entity3 and gelatinase response to a high-fat versus an isoenergetic low-fat meal in lean, healthy XXXX .

answer: @entity0


abstract: Fifty-five @entity0 with superior sulcus syndrome were treated at the UCLA Medical Center and Wadsworth VA Hospital (Los Angeles) between 1956 and 1985. Twenty-eight underwent surgery, six of whom were found unresectable at the time of thoracotomy. Twenty-one of 22 in the resected group received preoperative irradiation. Twenty-seven @entity0 received radiation only. Surgical morbidity was 21%, and there were two in-hospital deaths. Five-year survival for extended resection @entity0 was 34%. The radiation only group had no 5-year survivors. Factors associated with a worse prognosis include positive margins, @entity2 , and vertebral body involvement. The best results for superior @entity1 are obtained by preoperative irradiation followed by en bloc resection of the @entity1 . In the event complete resection is impossible, radiation has a role in palliation of @entity3 with occasional prolonged survival.

title: Factors affecting survival in superior XXXX .

answer: @entity1


abstract: Eleven @entity0 with primary @entity2 (CNS) were treated at the Medical College of Wisconsin Affiliated Hospitals between 1964 and 1984. Three @entity0 had a prior history of immunosuppressive therapy following renal transplantation. All @entity0 had biopsy-proven disease and 10 of the 11 were treated with external radiation therapy. The doses to the @entity1 ranged from 34 to 59.4 Gray (Gy). Actuarial (life-table) survival rate was 82% at 1 year and 43% at 3 years. No recurrence was seen after 13 months. Eighty-six reports totaling 693 cases of primary @entity3 of the CNS were found in the literature. Of these, 308 cases were treated with a combination of surgery and irradiation. Overall survival at 5 years for those @entity0 who received more than 50 Gy compared with less than 50 Gy to the @entity1 was 42.3% versus 12.8% (p less than 0.05). Twenty-one @entity0 survived longer than 5 years. Late relapse was notable, with 10 (47.6%) of 21 @entity1 recurring between 5 and 12.5 years after diagnosis. Based on this review, a minimum of 50 Gy radiation to the @entity1 is recommended. While no statement regarding the efficacy of craniospinal irradiation or chemotherapy can be made in view of the small numbers, the use of craniospinal irradiation and/or systemic chemotherapy should be considered for future trials.

title: Primary XXXX . Results of treatment of 11 cases and review of the literature.

answer: @entity2


abstract: @entity3 ( @entity3 ) is an unusual but serious complication of heparin therapy. Twenty-five @entity0 (13 @entity0 and 12 @entity0 ) had @entity3 and @entity1 1 to 10 days (mean, 6.3 days) after the start of heparin administration. The vessels in the affected extremity had been entered for catheterization, arteriography, or passage of a balloon counterpulsation device in 19 of the 25 @entity0 . In vitro @entity4 with heparin was seen in all @entity0 . Additional studies were performed to see whether other lots or sources of heparin also produced in vitro aggregation. Four separate lots of beef lung heparin, commercial heparin from porcine intestinal mucosa, and two types of low molecular weight heparin were all highly stimulatory in this system. However, @entity5 , a heparinoid, did not induce aggregation in any of 13 @entity0 plasmas tested. Inhibition of @entity4 by @entity2 was also examined. @entity2 abolished in vitro aggregation in 9 of 16 cases and decreased the degree of aggregation from 85% to 55% (p = 0.02) in the remaining seven cases. We conclude that in @entity0 with @entity3 @entity4 is equally induced by beef lung, porcine intestinal, and some forms of low molecular weight heparin. @entity5 does not stimulate @entity4 in plasma from these @entity0 in vitro. Finally, there may be a role for @entity2 in treating @entity0 with @entity3 .

title: XXXX : a serious clinical problem and potential solution.

answer: @entity3


abstract: Cordyceps sinensis, a caterpillar entomopathogenic fungus-host larva complex, is a rare medicinal herb found in the Qinghai-Tibetan Plateau and its surrounding @entity2 areas. The alternation of generations in the life cycle, whatever the fungus or its host insect, requires special growth conditions. However, it is difficult to simulate the growth conditions of @entity3 , which hinders its artificial cultivation. In this work, the life cycle from the host larva to @entity3 was observed in an indoor-cultivation laboratory at 4,200 m a.s.l. on Sejila Mountain, Tibet. Comparative examinations between indoor-cultivated and wild @entity3 demonstrated that the indoor-cultivated @entity3 preferred to germinate multiple long, slim stromata at diverse positions on dead larvae, including but not limited to their heads. Their @entity0 composition shows a significant difference in the levels of @entity1 ( @entity4 ). In indoor-cultivated @entity3 , @entity4 constituted 24.59% and 49.43%, respectively, of neutral and polar lipids; meanwhile, in wild @entity3 , @entity4 represented 34.34% and 61.25% of neutral and polar lipids, respectively. These observations and @entity0 data suggest that environmental factors, particularly temperature, soil pressure and light intensity, strongly affect the growth of @entity3 . Our new findings may provide important information for improving techniques for the large-scale artificial cultivation of @entity3 .

title: Morphological Observations and XXXX Composition of Indoor-Cultivated Cordyceps sinensis at a High-Altitude Laboratory on Sejila Mountain, Tibet.

answer: @entity0


abstract: BACKGROUND: @entity0 ( @entity0 ) is the most common form of @entity1 with a genetic predisposition. The relationship between polymorphisms in @entity4 or @entity2 promoter region and @entity0 has been addressed in many case-control studies, but the published results were not consistent. METHODS: A meta-analysis assessing the association between five single nucleotide polymorphisms (SNPs) (in @entity4 promoter: @entity5 and @entity6 ; in @entity2 promoter: @entity3 , @entity7 and @entity8 ) and the risk of @entity0 was performed based on included studies from literature research. In fixed effect model or random effect model, the Mantel-Haenszel (M-H) pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to evaluate the genetic association. Stratification analysis was also conducted to test the association within Asian or Caucasian populations. RESULTS: Twenty five case-control studies within multiple populations were identified and no publish bias was observed. Significant association was detected between @entity0 risk and @entity4 @entity6 in Caucasian (GA+AA vs. GG, OR=0.587, 95% CI=0.437-0.788, P < 0.001). For other SNPs and in other ethnic populations, no statistic evidence was detected for significant association between them and the development of @entity0 . CONCLUSIONS: This meta-analysis suggested a genetic association between one of @entity4 polymorphism ( @entity6 ) and the risk of @entity0 only in Caucasian population. The significant heterogeneity for this locus might imply the different @entity0 genetic basis among different populations.

title: Association of XXXX and @entity2 promoter polymorphisms and primary open-angle glaucoma: a meta-analysis.

answer: @entity4


abstract: BACKGROUND: @entity0 ( @entity0 ) is the most common form of @entity1 with a genetic predisposition. The relationship between polymorphisms in @entity4 or @entity2 promoter region and @entity0 has been addressed in many case-control studies, but the published results were not consistent. METHODS: A meta-analysis assessing the association between five single nucleotide polymorphisms (SNPs) (in @entity4 promoter: @entity5 and @entity6 ; in @entity2 promoter: @entity3 , @entity7 and @entity8 ) and the risk of @entity0 was performed based on included studies from literature research. In fixed effect model or random effect model, the Mantel-Haenszel (M-H) pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to evaluate the genetic association. Stratification analysis was also conducted to test the association within Asian or Caucasian populations. RESULTS: Twenty five case-control studies within multiple populations were identified and no publish bias was observed. Significant association was detected between @entity0 risk and @entity4 @entity6 in Caucasian (GA+AA vs. GG, OR=0.587, 95% CI=0.437-0.788, P < 0.001). For other SNPs and in other ethnic populations, no statistic evidence was detected for significant association between them and the development of @entity0 . CONCLUSIONS: This meta-analysis suggested a genetic association between one of @entity4 polymorphism ( @entity6 ) and the risk of @entity0 only in Caucasian population. The significant heterogeneity for this locus might imply the different @entity0 genetic basis among different populations.

title: Association of @entity4 and XXXX promoter polymorphisms and primary open-angle glaucoma: a meta-analysis.

answer: @entity2


abstract: This study is to explore and evaluate the efficacy and safety of local thrombolytic therapy in superior sagittal sinus in @entity0 with severe @entity2 during puerperium, as well as the efficacy and safety of anti-platelet aggregation treatment for preventing recurrence. Twelve @entity0 during postpartum period with @entity2 were received local thrombolytic therapy by placing a micro-catheter at the distal end of superior sagittal sinus from January 2008 to December 2013. All the @entity0 accepted mechanical @entity3 maceration before local intrasinus thrombolytic therapy, and were treated with low molecular weight heparin in the acute phase. After local thrombolytic therapy, anti-platelet aggregation treatment was performed for 6 months. Follow-up data included lumber puncture, fundus examination and magnetic resonance venography (MRV) once per half year for 6-70 months. At discharge, the intracranial pressure of 12 @entity0 reduced to below 200 mmH2O. DSA or MRV confirmed that superior sagittal sinus of 9 @entity0 were smooth. The cortex venous and deep venous were recovered to normal. Superior sagittal sinus of 3 @entity0 recanalized partly. Cortex venous and deep venous was compensated. The follow-up study indicated that no @entity3 and new @entity1 occurred among all @entity0 . Local thrombolytic treatment is safe and effective in @entity0 with severe @entity2 during puerperium. The collateral circulation compensation is the main recovery factor. And it is also safe and effective for anti-platelet aggregation treatment to prevent recurrence of @entity2 .

title: Local thrombolytic therapy in severe XXXX during puerperium.

answer: @entity2


abstract: Painful peripheral neuropathy due to the antiretroviral therapy used to treat @entity2 is one of the most prevalent side effects occurring in at least 30% of @entity0 living with this infection. We have evaluated the electrophysiological and behavioral effects of @entity5 and ddC on peripheral large and small nerve fibers in male @entity1 treated with @entity5 (Sprague-Dawley, 50 mg/kg, twice within 1 week), ddC ( @entity1 , 50 mg/kg, 3 times per week for 3 weeks), or vehicle. The effect of the interventions was assessed using behavioral measures of mechanical sensitivity, conventional nerve conduction studies, and microneurographic single nerve @entity3 recordings. To mimic as much as possible the @entity0 clinical condition, all treated animals were included in the study. No statistically significant differences were observed in behavioral parameters of mechanical sensitivity. Nerve conduction studies did not reveal any significant change in the @entity4 -treated group. In contrast, we observed electrophysiological evidence of significant demyelinating neuropathy 1 week after the start of @entity5 treatment. Additionally, spontaneous activity in mechanoinsensitive C-nociceptors was observed in both drug-treated groups. No relationship could be established between measures of spontaneous activity in C-nociceptors and the results of the behavioral tests. Our results show that both models of antiretroviral-induced neuropathy differ in their effects on peripheral nerves. However, both groups present abnormal spontaneous activity in mechanoinsensitive C-nociceptors that can be used as a model for pharmacological intervention.

title: Behavioral and electrophysiological abnormalities in two XXXX models of antiretroviral drug-induced neuropathy.

answer: @entity1


abstract: BACKGROUND: Alerts embedded in electronic health records (EHRs) are designed to improve processes at the point of care. OBJECTIVE: The aim of this study was to determine if an EHR alert-at @entity2 ( @entity2 ) triage-increases the @entity2 triage nurse's utilization of triage protocols. METHODS: @entity2 triage nurses were randomized to receive either a passive EHR alert or no intervention for @entity0 with the following complaints: minor @entity1 with extremity injuries or female @entity0 with @entity3 . The EHR alert notified the nurse that the @entity0 was eligible for diagnostic testing: radiographs for @entity0 with injured extremities or urinalysis for female @entity0 with @entity3 . RESULTS: Twenty-eight nurses triaged 20,410 @entity0 in the 6 months before the intervention and 19,157 in the 6 months after the intervention. Before the intervention, the urinalysis protocol was implemented in 101/624 (16.2%) @entity0 triaged by the intervention group and 116/711 (16.3%) triaged by the control group. After the intervention, the urinalysis protocol was implemented in 146/530 (27.6%) @entity0 triaged by the intervention group and 174/679 (25.6%) triaged by the control group. Before the intervention, the radiograph protocol was implemented in 58/774 (7.5%) @entity0 triaged by the intervention group and 45/684 (6.6%) triaged by the control group. After the intervention, the radiograph protocol was implemented in 78/614 (12.7%) @entity0 triaged by the intervention group and 79/609 (13.0%) triaged by the control group. CONCLUSION: The use of a passive EHR alert to promote @entity2 triage protocols showed little benefit. Before the widespread implementation of EHR alerts for @entity0 care, rigorous studies are required to determine the best alert methods and the impacts of such interventions.

title: Electronic alerts for triage protocol compliance among XXXX triage nurses: a randomized controlled trial.

answer: @entity2


abstract: UNASSIGNED: OBJECT Symptomatic pediatric @entity2 ( @entity2 ) is most often treated with @entity5 ( @entity5 ), but controversy exists over whether the dura needs to be opened during @entity5 . While dural opening as a part of @entity5 has been suggested to result in a higher rate of resolution of @entity1 , it has also been shown to lead to more frequent complications. In this paper, the authors present the largest reported series of outcomes after @entity5 without dural opening surgery, as well as identify risk factors for recurrence. METHODS The authors performed a retrospective review of 156 consecutive pediatric @entity0 in whom the senior authors performed @entity5 without dural opening from 2003 to 2013. @entity0 demographics, clinical symptoms and signs, radiographic findings, intraoperative ultrasound results, and neuromonitoring findings were reviewed. Univariate and multivariate regression analyses were performed to determine risk factors for recurrence of symptoms and the need for reoperation. RESULTS Over 90% of @entity0 had a good clinical outcome, with improvement or resolution of their symptoms at last follow-up (mean 32 months). There were no major complications. The mean length of hospital stay was 2.0 days. In a multivariate regression model, partial @entity3 laminectomy was an independent risk factor associated with reoperation (p = 0.037). Motor weakness on presentation was also associated with reoperation but only with trend-level significance (p = 0.075). No @entity0 with < 8 mm of @entity4 required reoperation. CONCLUSIONS The vast majority (> 90%) of @entity0 with symptomatic @entity2 will have improvement or resolution of symptoms after a @entity5 without dural opening. A non-dural opening approach avoids major complications. While no @entity0 with @entity4 < 8 mm required reoperation, @entity0 with @entity4 at or below @entity3 have a higher risk for failure when this approach is used.

title: Outcomes after suboccipital decompression without dural opening in @entity0 with XXXX .

answer: @entity2