abstract: BACKGROUND: @entity4 is a common @entity1 in the pediatric population, accounting for 25% of all childhood @entity2 and relatively uncommon in adults. This review was to investigate treatment outcome and prognostic factors after treatment of @entity4 . MATERIALS AND METHODS: A total of 53 @entity0 with histological confirmed @entity4 cases treated at our institute between 2006 and 2012 were included in the study. Demographic variables, clinical variables, radiological findings and treatment details with respect to age, sex, signs and symptoms, location of @entity1 , extent of surgical resection, histopathology type, radiotherapy dose, follow-up period and outcomes were recorded. Survival was analyzed by using these parameters. RESULTS: Thirty-one (58.5%) @entity0 were pediatric (<14 years), and 22 (41.5%) @entity0 were adults (>= 14 years). Duration of symptoms were <3 months in 19 (36%) and more than 3 months in 34 (64%) @entity0 . @entity1 resection was performed in all @entity0 with gross total resection in 8 (15%) @entity0 , near total resection in 34 (64%) @entity0 and subtotal resection in 11 (21%) @entity0 . All @entity0 underwent postoperative craniospinal irradiation (CSI) delivering a median craniospinal dose of 36 Gy with additional boosts to the posterior fossa up to 54 Gy. Median overall survival was 50 months for the total group whereas 36 months for pediatric age group and 70 months for adult group. @entity3 histology showed an improved outcome compared with other histologies with a median survival of 71 months compared with that of classical @entity4 histology being 36 months and other histologies shown a median survival of 34 only. CONCLUSIONS: Treatment of @entity4 with surgery and CSI yields long survival rates in both @entity0 and adults. Adult age group and desmoplastic histology were associated with a favorable outcome.

title: @entity4 : A common XXXX : Prognostic factors and predictors of outcome.

answer: @entity1


abstract: Studies of tissue cell locomotion in culture have revealed much about cell motility, but whether behaviour in vitro resembles movement of the same cells in the animal is not clear. To investigate this, I compared the locomotion and cell-substratum contacts of epidermal cells from @entity0 tadpoles, migrating from explants on glass and plastic, with the same cells spreading in vivo during wound closure. Time-lapse cinemicrography showed that in both cases, cells spread by extending broad lamellipodia across the substratum, and did not form microspikes, filopodia, or @entity3 . The net rate of translocation was significantly slower in vitro, however, because cells both @entity4 slower and spent more time stationary or withdrawing, compared with cells in situ. The increased fluctuation seemed in part due to greater @entity2 within the expanding sheet in vitro, since when @entity2 was reduced, for example by wounding, the cells spread with less fluctuation and at a greater rate (6.5 micrometers/min compared with 0.77 micrometers/min). Micromanipulation showed that cells adhered to the substratum, both in situ and in vitro, by a broad contact where @entity1 ( @entity1 ) of sectioned material showed the cells to be less than 30 nm from the substratum. A similar separation was observed beneath cells in vitro when viewed in life with interference-reflexion optics (IRM). A few focal contacts (adhesion plaques) were also seen with IRM and @entity1 of cells in vitro, but were not seen with @entity1 of cells in situ. Submarginal as well as marginal basal cells of the advancing sheet adhere and spread on the substratum in both situations, whereas cells of the outer layer are passive. Hence, the overall pattern of migration of these cells is similar in vitro and in situ; the differences in rates of movement may be explained in part by the different degree of @entity2 in the epithelium under the 2 conditions.

title: Locomotion and cell-substratum contacts of XXXX epidermal cells in vitro and in situ.

answer: @entity0


abstract: The only established role for complement in mediating immunologic @entity0 involves elaboration of leukochemotactic factors and neutrophil-dependent @entity0 . In the passive @entity3 (PHN) model of experimental @entity0 , @entity1 injected with sheep antibody to @entity1 proximal tubular brush border antigen (Fx1A) form subepithelial deposits of sheep IgG and @entity1 complement (C3), and develop heavy @entity2 after 5 d without glomerular inflammatory changes. To study the role of complement in mediating @entity2 in PHN, 16 @entity1 were treated daily with cobra venom factor from before antibody injection to maintain C3 levels at < 10% of pretreatment values and compared to 16 untreated controls. @entity2 at 5 d was abolished in C3-depleted @entity1 (4 +/- 1, controls 70 +/- 15 mg/d, P < 0.001), although renal deposition of 125I-labeled antibody ws the same in both groups (188 +/- 35 vs. 191 +/- 22 microgram IgG/2 kidneys, P > 0.5). Nephritogenic doses of both the noncomplement-fixing F(ab')2 portion and the gamma 2 subclass of anti-Fx1A IgG produced subepithelial deposits of immunoglobulin without C3, but @entity2 did not occur despite glomerular deposition of up to 70 microgram/2 kidneys of gamma 2. However, glomerular deposition of as little as 60 microgram of gamma 1 produced C3 fixation in vivo and heavy @entity2 . No neutrophil exudate could be detected histologically in PHN from the time of antibody injection through development of @entity2 . @entity2 in five PHN @entity1 depleted of neutrophils to < 200/mm3 with antineutrophil serum was not reduced compared to six controls with normal neutrophil counts (34 +/- 9.6 vs. 25 +/- 10.4 mg/d, P > 0.5). These results demonstrate that @entity2 in the PHN model of @entity0 is complement-dependent and strongly suggest a neutrophil-independent mechanism. Thus a new role for the complement system in mediating immunologic @entity0 is identified.

title: A new role for complement in experimental XXXX in @entity1 .

answer: @entity0


abstract: The only established role for complement in mediating immunologic @entity0 involves elaboration of leukochemotactic factors and neutrophil-dependent @entity0 . In the passive @entity3 (PHN) model of experimental @entity0 , @entity1 injected with sheep antibody to @entity1 proximal tubular brush border antigen (Fx1A) form subepithelial deposits of sheep IgG and @entity1 complement (C3), and develop heavy @entity2 after 5 d without glomerular inflammatory changes. To study the role of complement in mediating @entity2 in PHN, 16 @entity1 were treated daily with cobra venom factor from before antibody injection to maintain C3 levels at < 10% of pretreatment values and compared to 16 untreated controls. @entity2 at 5 d was abolished in C3-depleted @entity1 (4 +/- 1, controls 70 +/- 15 mg/d, P < 0.001), although renal deposition of 125I-labeled antibody ws the same in both groups (188 +/- 35 vs. 191 +/- 22 microgram IgG/2 kidneys, P > 0.5). Nephritogenic doses of both the noncomplement-fixing F(ab')2 portion and the gamma 2 subclass of anti-Fx1A IgG produced subepithelial deposits of immunoglobulin without C3, but @entity2 did not occur despite glomerular deposition of up to 70 microgram/2 kidneys of gamma 2. However, glomerular deposition of as little as 60 microgram of gamma 1 produced C3 fixation in vivo and heavy @entity2 . No neutrophil exudate could be detected histologically in PHN from the time of antibody injection through development of @entity2 . @entity2 in five PHN @entity1 depleted of neutrophils to < 200/mm3 with antineutrophil serum was not reduced compared to six controls with normal neutrophil counts (34 +/- 9.6 vs. 25 +/- 10.4 mg/d, P > 0.5). These results demonstrate that @entity2 in the PHN model of @entity0 is complement-dependent and strongly suggest a neutrophil-independent mechanism. Thus a new role for the complement system in mediating immunologic @entity0 is identified.

title: A new role for complement in experimental @entity0 in XXXX .

answer: @entity1


abstract: OBJECTIVES: Re-expansion @entity1 (RPO) sometimes occurs after minimally invasive cardiac surgery (MICS) with single-lung ventilation. However, it has not been widely recognized as a serious complication. The aim of this study is to evaluate the occurrence rate and risk factors of RPO. METHODS: A total of 381 consecutive @entity0 who underwent MICS with right mini-thoracotomy from March 2005 to October 2013 were retrospectively reviewed. RESULTS: RPO was observed in 8 (2.1%) @entity0 . In the preoperative data, greater percentages of preoperative use of @entity2 or immunosuppressant were found in @entity0 with RPO (25% [2/8] vs 1% [4/373]; P = 0.0056). In the operative data, significantly longer operation, cardiopulmonary bypass (CPB) and aortic cross-clamping (ACC) times as well as greater percentages of second CPB run were found in @entity0 with RPO (388    80 vs 272    61 min; P < 0.0002, 253    79 vs 158    50 min; P = 0.0009, 162    65 vs 108    38 min; P = 0.020 and 38% [3/8] vs 1.3% [5/373]; P < 0.0003). The overall 30-day mortality rate was 0.8% (3/381) and the 30-day mortality rate of @entity0 with RPO was 12.5% (1/8). Significantly prolonged initial ventilation time, intensive care unit and postoperative hospital stay were observed in @entity0 with RPO (P = 0.0022, <0.0001 and 0.0003, respectively). Multivariate logistic analysis detected preoperative use of @entity2 or immunosuppressant and prolonged ACC time (>= 156 min) as independent risk factors for RPO after MICS (odds ratio [OR]: 87.6 [95% confidence interval, CI: 4.1-2463.8]; P = 0.006 and OR: 36.0 [95% CI: 4.8-731.4]; P < 0.001). CONCLUSIONS: RPO should be recognized as one of the most serious complications after MICS with right mini-thoracotomy. More accurate risk factors of prolonged lung malperfusion and @entity2 use on RPO after MICS should be investigated.

title: Re-expansion XXXX after minimally invasive cardiac surgery with right mini-thoracotomy   .

answer: @entity1


abstract: Histochemical analyses @entity3 (ER) and @entity7 ( @entity8 ) receptors in @entity0 were statistically correlated with results of dextran-coated charcoal (DDC) and @entity6 gradient assays. Correlated for ER was 91% of 363 cases, and for @entity8 88% of 255 specimens. @entity0 ER/ @entity8 positivity by histochemistry correlated with a favorable clinical response to endocrine therapies in 72% of 25 cases, while ER/ @entity8 negativity correlated with a lack of response in 96% of 22 cases with @entity2 . Nuclear ER/ @entity8 correlated with a poor response to therapy in 8 of 12 @entity1 . An in vitro technique to detect nuclear translocation of ER revealed two groups of ER positive cases, with 11 of 17 exhibiting translocation and 6 not displaying translocation. In @entity4 , 72% of 65 @entity1 were positive for ER and/or @entity5 receptor. Comparison of specimens obtained without and with electrocautery revealed a preponderance of nuclear binding in the latter, suggesting heat-induced nuclear translocation of receptor. @entity9 , a naturally fluorescent, entirely unaltered @entity3 was also used for histochemical detection of ER. Results correlated with ER by DCC in 87% of 61 @entity0 . @entity9 was additionally used to visually observe receptor and nuclear translocation of ER in intact whole cells in culture.

title: Histochemical analyses of steroid hormone receptors in XXXX .

answer: @entity0


abstract: BACKGROUND: The objective of the study was to explore the expression features of serum miR-338-5p and soluble @entity1 (sBAFF) in renal transplant recipients. METHODS: Follow-up renal transplant recipients (n  = 49) were enrolled in this study (male/female: 38/11). Healthy volunteers were controlled; 2  mL of peripheral blood from each subject was collected. Total RNA was extracted from serum by use of the miRNeasy Serum/Plasma Kit (QIAGEN), and miR-338-5p was amplified by means of quantitative real-time reverse transcriptase-polymerase chain reaction. sBAFF was detected by means of enzyme-linked immunoassay. LABScreen Mix ( @entity2 ) (One Lambda) was used to test the level of anti-human leukocyte antigen (HLA) I antibody (Ab), anti-HLA II Ab, and anti-major histocompatibility complex class I chain-related A ( @entity0 ) Ab. All data are shown as mean    SD and were analyzed by use of SPSS software 17.0. RESULTS: Compared with healthy volunteers, serum miR-338-5p in recipients was statistically downregulated (2.79    2.5 versus 0.09    0.12, P  < .001); sBAFF in recipients was significantly upregulated (1321    950  pg/mL versus 534    327  pg/mL, P  < .01); serum anti-HLAII Ab, anti- @entity0 Ab, and anti-HLA+ @entity0 Abs all statistically increased in recipients (P  < .05). Spearman correlation analysis showed that miR-338-5p was significantly negatively correlated with sBAFF (r  =  -0.51, P  < .001) and anti-HLA II antibody with mean fluorescence intensity value >1000 (r  =  -0.322, P  < .05). Analysis results also suggested that sBAFF was significantly negatively correlated with anti- @entity0 Ab, with mean fluorescence intensity value >1000 (r  =  -0.579, P  < .05). CONCLUSIONS: miR-338-5p is closely correlated with the procedure of renal allograft antibody-mediated rejection.

title: Serum miR-338-5p, Soluble XXXX , Allo-Antibodies, and Renal Transplantation.

answer: @entity1


abstract: The mechanisms responsible for the development of a @entity0 (most commonly due to staphylococci) in the vicinity of an implanted foreign body have been studied recently by several investigators. Thus, we have been able to demonstrate that the phagocytic function of residential polymorphonuclear leukocytes (PMN) is deficient in the presence of a foreign body. Others have shown that in the presence of foreign surfaces, microorganisms produce extracellular amorphous material, the pathogenic role of which is still to be defined. In the present study we use a novel assay system to demonstrate that @entity2 Wood 46, after attachment to polymethylmethacrylate ( @entity4 ), shows increased resistance to the phagocytic-bactericidal action of normal PMN. The first step of this assay involves the reproducible attachment of @entity1 -labeled bacteria to @entity4 cover slips. During the second step, attached bacteria were exposed to @entity3 peritoneal exudate PMN. In the third and final step, attached @entity2 cells were removed from the cover slips using a procedure harmless to the bacteria. The extent of bacterial detachment was estimated by radioactive counts and their viability by standard colony counts. Whereas bacteria that were attached artificially and rapidly by centrifugation and immediately exposed to PMN were killed in the phagocytic assay, bacteria adhering spontaneously to the cover slips for a prolonged period of time were more resistant to the killing action of the phagocytes. The spontaneous adherence of @entity2 to @entity4 renders it poorly susceptible to the killing action of PMN.

title: Attachment of XXXX to polymethylmethacrylate increases its resistance to phagocytosis in @entity0 .

answer: @entity2


abstract: The mechanisms responsible for the development of a @entity0 (most commonly due to staphylococci) in the vicinity of an implanted foreign body have been studied recently by several investigators. Thus, we have been able to demonstrate that the phagocytic function of residential polymorphonuclear leukocytes (PMN) is deficient in the presence of a foreign body. Others have shown that in the presence of foreign surfaces, microorganisms produce extracellular amorphous material, the pathogenic role of which is still to be defined. In the present study we use a novel assay system to demonstrate that @entity2 Wood 46, after attachment to polymethylmethacrylate ( @entity4 ), shows increased resistance to the phagocytic-bactericidal action of normal PMN. The first step of this assay involves the reproducible attachment of @entity1 -labeled bacteria to @entity4 cover slips. During the second step, attached bacteria were exposed to @entity3 peritoneal exudate PMN. In the third and final step, attached @entity2 cells were removed from the cover slips using a procedure harmless to the bacteria. The extent of bacterial detachment was estimated by radioactive counts and their viability by standard colony counts. Whereas bacteria that were attached artificially and rapidly by centrifugation and immediately exposed to PMN were killed in the phagocytic assay, bacteria adhering spontaneously to the cover slips for a prolonged period of time were more resistant to the killing action of the phagocytes. The spontaneous adherence of @entity2 to @entity4 renders it poorly susceptible to the killing action of PMN.

title: Attachment of @entity2 to polymethylmethacrylate increases its resistance to phagocytosis in XXXX .

answer: @entity0


abstract: The charts of 36 @entity0 , 27 males and 9 females, with @entity2 diagnosed at the Hadassah University Hospital between 1967-1977 were reviewed. The @entity0 ranged in age from two months to 80 years and 25 @entity0 (69%) were older than 40 years. The diagnosis was initially suggested by liver scan in 18 @entity0 (50%), and was first made at autopsy in six (17%). The time-lapse between the onset of illness and diagnosis ranged from one day to 13 months, with a bimodal distribution. Large solitary abscesses were diagnosed later than small multiple abscesses. Ten @entity0 (28%) were admitted with fever as the only sign of illness; specific signs and laboratory evidence of liver involvement often occurred late in the course of the disease. In 15 @entity0 (42%), the etiology was regarded as amebic. In @entity0 with pyogenic abscesses, the most commonly isolated organisms belonged to the normal bowel flora and @entity1 was present in 62% (13/21) of these @entity0 . The overall mortality rate was 31%. This survey stresses the need for an increased awareness of the subtle presentation of @entity2 .

title: XXXX at the Hadassah University during years 1967-77.

answer: @entity2


abstract: OBJECTIVE: To calculate dose delivered to the lumbosacral plexus (LSP) with cervical brachytherapy using 3-dimensional imaging, and to compare this with the position of the tandem in the pelvis using bony landmarks. We also report long-term LSP @entity3 outcomes. METHODS AND MATERIALS: Treatment planning images from 55 @entity0 treated with tandem and ring brachytherapy from October 2009 through November 2012 were reviewed. The LSP was contoured on planning computed tomographic scans to calculate dose received.Lumbosacral plexus dose was studied as a function of tandem distance from the sacrum and pubic symphysis (STratio) measured on digitally reconstructed radiographs. @entity0 and implant characteristics were included as covariates on LSP dose. Clinical follow up on LSP @entity3 was recorded. RESULTS: @entity0 were prescribed 550 to 700 cGy using computed tomography-based imaged-guided brachytherapy for 4 to 5 fractions. The maximum dose to 2 cc (D2cc) of LSP ranged from 44 to 287 cGy per implant. The median D2cc was 118 cGy, corresponding to 18% of prescription dose. @entity0 with an STratio less than 0.33 (closer to the sacrum) and at least 0.33 had median LSP doses of 138 and 98 cGy, respectively. Lumbosacral plexus dose did not change significantly with body mass index, uterus position, or @entity1 stage. Two @entity0 reported symptoms of @entity4 , with a median follow-up of 14.7 months. CONCLUSIONS: The mean D2cc per fraction to the LSP is roughly 20% of the prescribed high dose-rate and varies with the position of the tandem from the sacrum. The dose threshold for radiation-induced @entity2 of the LSP remains undefined.

title: Dose Delivered to the Lumbosacral Plexus From High-Dose-Rate Brachytherapy for XXXX .

answer: @entity1


abstract: AIMS AND BACKGROUND: The main objective of this study is to evaluate outcomes of bladder preservation treatment for @entity0 with @entity3 . METHODS AND STUDY DESIGN: 38 @entity0 with histologically proven @entity3 treated at our department between January 2008 and December 2013 were analyzed retrospectively. Age, gender, pathology, stage, 3-year overall survival, 3-year disease-free survival, radiotherapy (RT) dose, genitourinary and gastrointestinal @entity2 scores and response evaluation of the @entity0 were recorded. 3-year overall survival and 3-year disease-free survivals were calculated by Kaplan-Meier method along with the analysis of gender, pathology, stage and therapy response of the study group. RESULTS: 33 @entity0 (86.8%) were managed with concomitant chemoradiotherapy whereas 5 @entity0 (13.2%) received only radiation therapy due to @entity1 . 6 (15.8%) out of 38 @entity0 had partial response (PR) and remaining 32 (84.2%) @entity0 experienced complete response (CR). The PR group underwent salvage cystectomy and CR group had been followed-up after radical radiotherapy. Mean age of the group was 70.9 (range 45-90) years. 26 of all @entity0 were male (68.4%) and 12 were female (31.6%). Mean follow-up time after completion of radiotherapy was 24.7 months (range 12-40). Mean RT dose was 64 Gy (range 60-66). 3-year overall survival was 64% and 3-year disease free survival was 73%. CONCLUSIONS: Bladder preserving approach is an alternative definitive therapy solution to radical cystectomy in the treatment of @entity3 with less morbidity, preserved natural bladder, and high quality of life.

title: Outcomes of trimodality approach in the management of T2N0M0 XXXX .

answer: @entity3


abstract: UNASSIGNED: @entity5 have been identified as the primary cause of injury in 5% of U.S. military personnel evacuated from Operations Iraqi Freedom and Enduring Freedom. Severe burn-associated @entity6 is typically treated with opioids such as @entity15 , @entity11 , and @entity7 . Side effects of opioids include @entity13 , @entity8 , decrease in motor and cognitive function, as well as the development of @entity14 , tolerance and @entity9 . These effects have led us to search for novel analgesics for the treatment of burn-associated @entity6 in wounded combat service members. @entity10 ( @entity17 ) is a selective voltage-gated @entity12 channel blocker currently in clinical trials as an analgesic. A phase 3 clinical trial for @entity1 -related @entity6 has been completed and phase 3 clinical trials on chemotherapy-induced @entity2 are planned. It has also been shown in @entity3 to inhibit the development of chemotherapy-induced @entity2 . @entity17 was originally identified as a neurotoxin in marine animals but has now been shown to be safe in @entity0 at therapeutic doses. The antinociceptive effects of @entity17 are thought to be due to inhibition of @entity16 ion influx required for initiation and conduction of nociceptive impulses. One @entity17 sensitive @entity12 channel, @entity18 , has been shown to be essential in lowering the @entity6 threshold after @entity5 . To date, the analgesic effect of @entity17 has not been tested in burn-associated @entity6 . Male @entity4 were subjected to a full thickness @entity5 on the right hind paw. @entity17 (8 g/kg) was administered once a day systemically by subcutaneous injection beginning 3 days post @entity5 and continued through 7 days post @entity5 . Thermal @entity14 and mechanical @entity14 were assessed 60 and 120min post injection on each day of @entity17 treatment. @entity17 significantly reduced thermal @entity14 at all days tested and had a less robust, but statistically significant suppressive effect on mechanical @entity14 . These results suggest that systemic @entity17 may be an effective, rapidly acting analgesic for battlefield @entity5 and has the potential for replacing or reducing the need for opioid analgesics.

title: XXXX suppresses thermal @entity14 and mechanical @entity14 in a @entity4 full thickness @entity5 pain model.

answer: @entity10


abstract: UNASSIGNED: @entity5 have been identified as the primary cause of injury in 5% of U.S. military personnel evacuated from Operations Iraqi Freedom and Enduring Freedom. Severe burn-associated @entity6 is typically treated with opioids such as @entity15 , @entity11 , and @entity7 . Side effects of opioids include @entity13 , @entity8 , decrease in motor and cognitive function, as well as the development of @entity14 , tolerance and @entity9 . These effects have led us to search for novel analgesics for the treatment of burn-associated @entity6 in wounded combat service members. @entity10 ( @entity17 ) is a selective voltage-gated @entity12 channel blocker currently in clinical trials as an analgesic. A phase 3 clinical trial for @entity1 -related @entity6 has been completed and phase 3 clinical trials on chemotherapy-induced @entity2 are planned. It has also been shown in @entity3 to inhibit the development of chemotherapy-induced @entity2 . @entity17 was originally identified as a neurotoxin in marine animals but has now been shown to be safe in @entity0 at therapeutic doses. The antinociceptive effects of @entity17 are thought to be due to inhibition of @entity16 ion influx required for initiation and conduction of nociceptive impulses. One @entity17 sensitive @entity12 channel, @entity18 , has been shown to be essential in lowering the @entity6 threshold after @entity5 . To date, the analgesic effect of @entity17 has not been tested in burn-associated @entity6 . Male @entity4 were subjected to a full thickness @entity5 on the right hind paw. @entity17 (8 g/kg) was administered once a day systemically by subcutaneous injection beginning 3 days post @entity5 and continued through 7 days post @entity5 . Thermal @entity14 and mechanical @entity14 were assessed 60 and 120min post injection on each day of @entity17 treatment. @entity17 significantly reduced thermal @entity14 at all days tested and had a less robust, but statistically significant suppressive effect on mechanical @entity14 . These results suggest that systemic @entity17 may be an effective, rapidly acting analgesic for battlefield @entity5 and has the potential for replacing or reducing the need for opioid analgesics.

title: @entity10 suppresses thermal XXXX and mechanical @entity14 in a @entity4 full thickness @entity5 pain model.

answer: @entity14


abstract: UNASSIGNED: @entity5 have been identified as the primary cause of injury in 5% of U.S. military personnel evacuated from Operations Iraqi Freedom and Enduring Freedom. Severe burn-associated @entity6 is typically treated with opioids such as @entity15 , @entity11 , and @entity7 . Side effects of opioids include @entity13 , @entity8 , decrease in motor and cognitive function, as well as the development of @entity14 , tolerance and @entity9 . These effects have led us to search for novel analgesics for the treatment of burn-associated @entity6 in wounded combat service members. @entity10 ( @entity17 ) is a selective voltage-gated @entity12 channel blocker currently in clinical trials as an analgesic. A phase 3 clinical trial for @entity1 -related @entity6 has been completed and phase 3 clinical trials on chemotherapy-induced @entity2 are planned. It has also been shown in @entity3 to inhibit the development of chemotherapy-induced @entity2 . @entity17 was originally identified as a neurotoxin in marine animals but has now been shown to be safe in @entity0 at therapeutic doses. The antinociceptive effects of @entity17 are thought to be due to inhibition of @entity16 ion influx required for initiation and conduction of nociceptive impulses. One @entity17 sensitive @entity12 channel, @entity18 , has been shown to be essential in lowering the @entity6 threshold after @entity5 . To date, the analgesic effect of @entity17 has not been tested in burn-associated @entity6 . Male @entity4 were subjected to a full thickness @entity5 on the right hind paw. @entity17 (8 g/kg) was administered once a day systemically by subcutaneous injection beginning 3 days post @entity5 and continued through 7 days post @entity5 . Thermal @entity14 and mechanical @entity14 were assessed 60 and 120min post injection on each day of @entity17 treatment. @entity17 significantly reduced thermal @entity14 at all days tested and had a less robust, but statistically significant suppressive effect on mechanical @entity14 . These results suggest that systemic @entity17 may be an effective, rapidly acting analgesic for battlefield @entity5 and has the potential for replacing or reducing the need for opioid analgesics.

title: @entity10 suppresses thermal @entity14 and mechanical XXXX in a @entity4 full thickness @entity5 pain model.

answer: @entity14


abstract: UNASSIGNED: @entity5 have been identified as the primary cause of injury in 5% of U.S. military personnel evacuated from Operations Iraqi Freedom and Enduring Freedom. Severe burn-associated @entity6 is typically treated with opioids such as @entity15 , @entity11 , and @entity7 . Side effects of opioids include @entity13 , @entity8 , decrease in motor and cognitive function, as well as the development of @entity14 , tolerance and @entity9 . These effects have led us to search for novel analgesics for the treatment of burn-associated @entity6 in wounded combat service members. @entity10 ( @entity17 ) is a selective voltage-gated @entity12 channel blocker currently in clinical trials as an analgesic. A phase 3 clinical trial for @entity1 -related @entity6 has been completed and phase 3 clinical trials on chemotherapy-induced @entity2 are planned. It has also been shown in @entity3 to inhibit the development of chemotherapy-induced @entity2 . @entity17 was originally identified as a neurotoxin in marine animals but has now been shown to be safe in @entity0 at therapeutic doses. The antinociceptive effects of @entity17 are thought to be due to inhibition of @entity16 ion influx required for initiation and conduction of nociceptive impulses. One @entity17 sensitive @entity12 channel, @entity18 , has been shown to be essential in lowering the @entity6 threshold after @entity5 . To date, the analgesic effect of @entity17 has not been tested in burn-associated @entity6 . Male @entity4 were subjected to a full thickness @entity5 on the right hind paw. @entity17 (8 g/kg) was administered once a day systemically by subcutaneous injection beginning 3 days post @entity5 and continued through 7 days post @entity5 . Thermal @entity14 and mechanical @entity14 were assessed 60 and 120min post injection on each day of @entity17 treatment. @entity17 significantly reduced thermal @entity14 at all days tested and had a less robust, but statistically significant suppressive effect on mechanical @entity14 . These results suggest that systemic @entity17 may be an effective, rapidly acting analgesic for battlefield @entity5 and has the potential for replacing or reducing the need for opioid analgesics.

title: @entity10 suppresses thermal @entity14 and mechanical @entity14 in a @entity4 full thickness XXXX pain model.

answer: @entity5


abstract: UNASSIGNED: @entity5 have been identified as the primary cause of injury in 5% of U.S. military personnel evacuated from Operations Iraqi Freedom and Enduring Freedom. Severe burn-associated @entity6 is typically treated with opioids such as @entity15 , @entity11 , and @entity7 . Side effects of opioids include @entity13 , @entity8 , decrease in motor and cognitive function, as well as the development of @entity14 , tolerance and @entity9 . These effects have led us to search for novel analgesics for the treatment of burn-associated @entity6 in wounded combat service members. @entity10 ( @entity17 ) is a selective voltage-gated @entity12 channel blocker currently in clinical trials as an analgesic. A phase 3 clinical trial for @entity1 -related @entity6 has been completed and phase 3 clinical trials on chemotherapy-induced @entity2 are planned. It has also been shown in @entity3 to inhibit the development of chemotherapy-induced @entity2 . @entity17 was originally identified as a neurotoxin in marine animals but has now been shown to be safe in @entity0 at therapeutic doses. The antinociceptive effects of @entity17 are thought to be due to inhibition of @entity16 ion influx required for initiation and conduction of nociceptive impulses. One @entity17 sensitive @entity12 channel, @entity18 , has been shown to be essential in lowering the @entity6 threshold after @entity5 . To date, the analgesic effect of @entity17 has not been tested in burn-associated @entity6 . Male @entity4 were subjected to a full thickness @entity5 on the right hind paw. @entity17 (8 g/kg) was administered once a day systemically by subcutaneous injection beginning 3 days post @entity5 and continued through 7 days post @entity5 . Thermal @entity14 and mechanical @entity14 were assessed 60 and 120min post injection on each day of @entity17 treatment. @entity17 significantly reduced thermal @entity14 at all days tested and had a less robust, but statistically significant suppressive effect on mechanical @entity14 . These results suggest that systemic @entity17 may be an effective, rapidly acting analgesic for battlefield @entity5 and has the potential for replacing or reducing the need for opioid analgesics.

title: @entity10 suppresses thermal @entity14 and mechanical @entity14 in a XXXX full thickness @entity5 pain model.

answer: @entity4


abstract: UNASSIGNED: Current @entity2 guidelines advocate strategies encouraging healthy lifestyle behaviours. So far, there is a paucity of studies for the efficacy of such multifaceted programmes. The aim of this study is to investigate the efficacy of an 8-week health-promotion programme for lowering blood pressure (BP) in @entity6 and @entity2 @entity0 in the community. This was a quasi-experimental study using wait-list controls of 548 @entity0 . The intervention group was administered with an 8-week health-promotion intervention. Measurements included home BP, smoking, body mass index (BMI), perceived stress, @entity4 , @entity3 and Health Locus of Control. After adjusting for confounders, the intervention group had a significant @entity5 ( @entity8 ; mean -2.62   mm   Hg, 95% confidence interval (CI): -1.29 to -3.96) and @entity5 ( @entity5 ; mean -1.0, 95% CI: -0.93 to -1.9) compared with controls. In all, 14.9% of @entity0 in the intervention group had >10   mm   @entity7 reduction in @entity8 vs 4.4% in the control group (P<0.001, numbers needed to treat (NNT)=10). With regards to @entity5 , 21.7% of @entity0 in the intervention group had >5   mm   Hg reduction vs 12.5% in the control group (P=0.01, NNT=11). In terms of effect size, moderate-to-large improvements of BMI, perceived stress, @entity3 , @entity4 , external and chance Health Locus of Control were recorded. Changes in @entity8 and @entity5 were attributed to BMI and depressive symptom reductions, respectively. Comprehensive non-pharmaceutical programmes for BP management are strongly encouraged. Their long-term benefits on @entity1 and mortality remain to be established by future research.Journal of @entity0 @entity2 advance online publication, 1 October 2015; doi:10.1038/jhh.2015.99.

title: A HEALth Promotion and STRESS Management Program (HEAL-STRESS study) for XXXX and @entity2 @entity0 : a quasi-experimental study in Greece.

answer: @entity6


abstract: UNASSIGNED: Current @entity2 guidelines advocate strategies encouraging healthy lifestyle behaviours. So far, there is a paucity of studies for the efficacy of such multifaceted programmes. The aim of this study is to investigate the efficacy of an 8-week health-promotion programme for lowering blood pressure (BP) in @entity6 and @entity2 @entity0 in the community. This was a quasi-experimental study using wait-list controls of 548 @entity0 . The intervention group was administered with an 8-week health-promotion intervention. Measurements included home BP, smoking, body mass index (BMI), perceived stress, @entity4 , @entity3 and Health Locus of Control. After adjusting for confounders, the intervention group had a significant @entity5 ( @entity8 ; mean -2.62   mm   Hg, 95% confidence interval (CI): -1.29 to -3.96) and @entity5 ( @entity5 ; mean -1.0, 95% CI: -0.93 to -1.9) compared with controls. In all, 14.9% of @entity0 in the intervention group had >10   mm   @entity7 reduction in @entity8 vs 4.4% in the control group (P<0.001, numbers needed to treat (NNT)=10). With regards to @entity5 , 21.7% of @entity0 in the intervention group had >5   mm   Hg reduction vs 12.5% in the control group (P=0.01, NNT=11). In terms of effect size, moderate-to-large improvements of BMI, perceived stress, @entity3 , @entity4 , external and chance Health Locus of Control were recorded. Changes in @entity8 and @entity5 were attributed to BMI and depressive symptom reductions, respectively. Comprehensive non-pharmaceutical programmes for BP management are strongly encouraged. Their long-term benefits on @entity1 and mortality remain to be established by future research.Journal of @entity0 @entity2 advance online publication, 1 October 2015; doi:10.1038/jhh.2015.99.

title: A HEALth Promotion and STRESS Management Program (HEAL-STRESS study) for @entity6 and XXXX @entity0 : a quasi-experimental study in Greece.

answer: @entity2


abstract: UNASSIGNED: Current @entity2 guidelines advocate strategies encouraging healthy lifestyle behaviours. So far, there is a paucity of studies for the efficacy of such multifaceted programmes. The aim of this study is to investigate the efficacy of an 8-week health-promotion programme for lowering blood pressure (BP) in @entity6 and @entity2 @entity0 in the community. This was a quasi-experimental study using wait-list controls of 548 @entity0 . The intervention group was administered with an 8-week health-promotion intervention. Measurements included home BP, smoking, body mass index (BMI), perceived stress, @entity4 , @entity3 and Health Locus of Control. After adjusting for confounders, the intervention group had a significant @entity5 ( @entity8 ; mean -2.62   mm   Hg, 95% confidence interval (CI): -1.29 to -3.96) and @entity5 ( @entity5 ; mean -1.0, 95% CI: -0.93 to -1.9) compared with controls. In all, 14.9% of @entity0 in the intervention group had >10   mm   @entity7 reduction in @entity8 vs 4.4% in the control group (P<0.001, numbers needed to treat (NNT)=10). With regards to @entity5 , 21.7% of @entity0 in the intervention group had >5   mm   Hg reduction vs 12.5% in the control group (P=0.01, NNT=11). In terms of effect size, moderate-to-large improvements of BMI, perceived stress, @entity3 , @entity4 , external and chance Health Locus of Control were recorded. Changes in @entity8 and @entity5 were attributed to BMI and depressive symptom reductions, respectively. Comprehensive non-pharmaceutical programmes for BP management are strongly encouraged. Their long-term benefits on @entity1 and mortality remain to be established by future research.Journal of @entity0 @entity2 advance online publication, 1 October 2015; doi:10.1038/jhh.2015.99.

title: A HEALth Promotion and STRESS Management Program (HEAL-STRESS study) for @entity6 and @entity2 XXXX : a quasi-experimental study in Greece.

answer: @entity0


abstract: OBJECT Structural spinal surgery yields improvement in @entity2 and disability for selected @entity0 with @entity4 , spondylolisthesis, or a herniated @entity5 . A significant fraction of @entity0 exhibit persistent postoperative @entity1 (PPNP) despite technically appropriate intervention, and such @entity0 can benefit from @entity3 ( @entity3 ) to alleviate suffering. The complication profile of this therapy has not been systematically assessed and, thus, was the goal of this review. METHODS A comprehensive literature search was performed to identify prospective cohorts of @entity0 who had PPNP following structurally corrective lumbar spinal surgery and who underwent @entity3 device implantation. Data about study design, technique of @entity3 lead introduction, and complications encountered were collected and analyzed. Comparisons of complication incidence were performed between percutaneously and surgically implanted systems, with the level of significance set at 0.05. RESULTS Review of 11 studies involving 542 @entity0 formed the basis of this work: 2 randomized controlled trials and 9 prospective cohorts. Percutaneous implants were used in 4 studies and surgical implants were used in 4 studies; in the remainder, the types were undefined. Lead migration occurred in 12% of cases, @entity2 at the site of the implantable pulse generator occurred in 9% of cases, and wound-related complications occurred in 5% of cases; the latter 2 occurred more frequently among surgically implanted devices. CONCLUSIONS Spinal cord stimulation can provide for improved @entity2 and suffering and for decreased narcotic medication use among @entity0 with PPNP after lumbar spinal surgery. This study reviewed the prospective studies forming the evidence base for this therapy, to summarize the complications encountered and, thus, best inform @entity0 and clinicians considering its use. There is a significant rate of minor complications, many of which require further surgical intervention to manage, including lead migration or implant infection, although such complications do not directly threaten @entity0 life or function.

title: Complications related to the use of XXXX for managing persistent postoperative @entity1 after lumbar spinal surgery.

answer: @entity3


abstract: OBJECT Structural spinal surgery yields improvement in @entity2 and disability for selected @entity0 with @entity4 , spondylolisthesis, or a herniated @entity5 . A significant fraction of @entity0 exhibit persistent postoperative @entity1 (PPNP) despite technically appropriate intervention, and such @entity0 can benefit from @entity3 ( @entity3 ) to alleviate suffering. The complication profile of this therapy has not been systematically assessed and, thus, was the goal of this review. METHODS A comprehensive literature search was performed to identify prospective cohorts of @entity0 who had PPNP following structurally corrective lumbar spinal surgery and who underwent @entity3 device implantation. Data about study design, technique of @entity3 lead introduction, and complications encountered were collected and analyzed. Comparisons of complication incidence were performed between percutaneously and surgically implanted systems, with the level of significance set at 0.05. RESULTS Review of 11 studies involving 542 @entity0 formed the basis of this work: 2 randomized controlled trials and 9 prospective cohorts. Percutaneous implants were used in 4 studies and surgical implants were used in 4 studies; in the remainder, the types were undefined. Lead migration occurred in 12% of cases, @entity2 at the site of the implantable pulse generator occurred in 9% of cases, and wound-related complications occurred in 5% of cases; the latter 2 occurred more frequently among surgically implanted devices. CONCLUSIONS Spinal cord stimulation can provide for improved @entity2 and suffering and for decreased narcotic medication use among @entity0 with PPNP after lumbar spinal surgery. This study reviewed the prospective studies forming the evidence base for this therapy, to summarize the complications encountered and, thus, best inform @entity0 and clinicians considering its use. There is a significant rate of minor complications, many of which require further surgical intervention to manage, including lead migration or implant infection, although such complications do not directly threaten @entity0 life or function.

title: Complications related to the use of @entity3 for managing persistent postoperative XXXX after lumbar spinal surgery.

answer: @entity1


abstract: OBJECTIVE: Perioperative complications in @entity0 undergoing transcatheter @entity5 remain a major issue affecting outcome. Because preoperative risk adjustment remains challenging and a valid scoring system is missing, we sought to determine the incidence of peri- and postprocedural complications of transapical (TA) or transaortic (TAO) access to define the influence of specific complications on early safety, 30-day mortality, and 1-year survival. Furthermore, we aimed to develop a risk-stratification model to allow an estimation of the perioperative risk and the 1-year survival rate, based on the individual preoperative condition of each @entity0 . METHODS: We performed an outcome analysis of 230 consecutive @entity0 who underwent @entity5 via transapical or transaortic access between 2008 and 2012, with regard to Valve @entity6 , including univariate and multivariable regression analysis, to develop a risk-stratification model. RESULTS: Thirty-day mortality was 12.7%. Estimated 1-year survival was 0.69 (95% confidence interval [CI], 0.631-0.757), and 3-year survival was 0.554 (95% CI, 0.474-0.634). Univariate logistic regression analysis revealed a significant influence on 30-day mortality in case of life-threatening @entity2 (16.1-fold), abdominal complications (8.5-fold), and @entity4 (3.2-fold). Pacemaker implantation (odds ratio, 1.55; 95% CI, 0.42-5.81; P  =  .512) was not a significant predictor. Concerning use of intraprocedural hemodynamic bridging therapy via cardiopulmonary bypass (CPB), Cox regression analysis revealed no significant survival difference after 1  year. A preoperative risk-stratification model for 1-year survival revealed that a logistic European System for Cardiac Operative Risk Evaluation score >20%, preoperative existing @entity1 , and prior @entity3 appeared to be significant predictors for diminished survival. CONCLUSIONS: Concerning intraprocedural complications, CPB support for hemodynamic stabilization is a safe treatment option. Therefore, the heart team approach with CPB standby represents a life-saving option. Attention should also be drawn to  specialized and individual postoperative care, because nonprocedure-specific complications clearly affect postoperative short- and long-term outcome. In addition, the risk-stratification model might facilitate preoperative decision making.

title: Focus on the surgical approach to transcatheter XXXX : Complications, outcome, and preoperative risk adjustment.

answer: @entity5


abstract: PURPOSE: To evaluate risk factors for deterioration of lower urinary tract symptoms (LUTS) in elderly @entity0 in a community-based, prospective longitudinal cohort study. METHODS: In a suburban area in Korea, 1,514 subjects aged >= 45 years were randomly selected by systematic sampling. A total of 918 elderly subjects were enrolled in this in-depth clinical study in 2004. Of these, 547 @entity0 were followed up for 3 years and the data was analyzed in 2014. Standard questionnaires were administered face-to-face by trained interviewers. After excluding @entity0 , 224 male @entity0 with complete data including transrectal ultrasonography were included in the final analysis. LUTS were diagnosed using the International Prostate Symptom Score (IPSS) questionnaire. Symptom deterioration was defined as a score of >= 8 points during the 3-year follow-up period. RESULTS: LUTS prevalence increased to 13.1% and the mean IPSS increased by 2.6 points during the 3-year period. After adjusting for confounders, a smoking history of >= 50 pack-years was an independent risk factor for deterioration of LUTS and storage subsymptoms compared with no history of smoking (3.1 and 5.1 odds, respectively). Physical activity had a protective effect on voiding subsymptoms. However, high protein diet and @entity1 intake were not associated with LUTS deterioration. CONCLUSIONS: The LUTS prevalence among elderly @entity0 living in a suburban area increased to 13.1% and the IPSS increased by 2.6 points during the 3-year period. A history of heavy smoking, low physical activity, and high protein intake were associated with LUTS deterioration. However, there was no significant association between @entity1 intake and LUTS deterioration.

title: XXXX , Smoking, Physical Activity, Protein, and Lower Urinary Tract Symptoms: Prospective Longitudinal Cohort.

answer: @entity1


abstract: BACKGROUND: Unplanned care interruption (UCI) challenges effective @entity2 treatment. We determined the frequency and risk factors for UCI in Nigeria. METHODS: We conducted a retrospective-cohort study of adults initiating antiretroviral therapy (ART) between January 2009 and December 2011. At censor, @entity0 were defined as in care, UCI, or inactive. Associations between baseline factors and UCI rates were quantified using Poisson regression. RESULTS: Among 2,496 @entity0 , 44 % remained in care, 35 % had >= 1 UCI, and 21 % became inactive. UCI rates were higher in the first year on ART (39/100PY), than the second (19/100PY), third (16/100PY), and fourth (14/100PY) years (p   <   0.001). In multivariate analysis, baseline @entity1   >   350/uL ( @entity3 3.21, p   <   0.0001), being a student ( @entity3 1.95, p   <   0.0001), and less education ( @entity3 1.58, p   =   0.001) increased risk for UCI. Fifty-five percent of @entity0 with UCI and viral load data had @entity2 viral load   >   1,000 copies/ml upon return to care. DISCUSSION: UCI were observed in over one-third of @entity0 treated, and were most common in the first year on ART. High baseline @entity1 count at ART initiation was the greatest predictor of subsequent UCI. CONCLUSIONS: Interventions focused on the first year on ART are needed to improve continuity of @entity2 care.

title: High rates of unplanned interruptions from XXXX care early after antiretroviral therapy initiation in Nigeria.

answer: @entity2


abstract: UNASSIGNED: @entity7 resistance (IR) and @entity2 are associated with an increased risk of @entity3 and may contribute to @entity4 . The earliest sign of @entity4 is impaired left ventricular (LV) diastolic function, which may be evident in @entity1 @entity0 and adolescents. However, the precise metabolic basis of the impaired LV diastolic function remains unknown. The aims of this study were to evaluate cardiac structure and LV diastolic function by tissue Doppler imaging in overweight and @entity1 and to assess the relative individual contributions of adiposity, IR, and @entity2 to alterations in cardiac structure and function. We studied 35 OW (body mass index standard deviation score 2.0    0.8; non-IR n  = 19, IR n  = 16) and 34 non-OW youth (body mass index standard deviation score 0.1    0.7). LV diastolic function was reduced in OW youth compared with non-OW controls, as indicated by lower peak myocardial relaxation velocities (p <0.001) and greater filling pressures (p <0.001). OW youth also had greater LV mass index (p <0.001), left atrial volume index, and LV interventricular septal thickness (LV-IVS; both p  = 0.02). IR-OW youth had the highest LV filling pressures, LV-IVS, and relative wall thickness (all p <0.05). Homeostasis model of assessment- @entity7 resistance and @entity6 were negative determinants of peak myocardial relaxation velocity and positive predictors of filling pressure. @entity5 was a negative determinant of LV-IVS, independent of @entity1 . In conclusion, OW youth with IR and @entity2 are more likely to have adverse changes to cardiovascular structure and function which may predispose to premature @entity3 in adulthood.

title: Relation of Reduced Preclinical Left Ventricular Diastolic Function and Cardiac Remodeling in Overweight Youth to XXXX Resistance and @entity2 .

answer: @entity7


abstract: UNASSIGNED: @entity7 resistance (IR) and @entity2 are associated with an increased risk of @entity3 and may contribute to @entity4 . The earliest sign of @entity4 is impaired left ventricular (LV) diastolic function, which may be evident in @entity1 @entity0 and adolescents. However, the precise metabolic basis of the impaired LV diastolic function remains unknown. The aims of this study were to evaluate cardiac structure and LV diastolic function by tissue Doppler imaging in overweight and @entity1 and to assess the relative individual contributions of adiposity, IR, and @entity2 to alterations in cardiac structure and function. We studied 35 OW (body mass index standard deviation score 2.0    0.8; non-IR n  = 19, IR n  = 16) and 34 non-OW youth (body mass index standard deviation score 0.1    0.7). LV diastolic function was reduced in OW youth compared with non-OW controls, as indicated by lower peak myocardial relaxation velocities (p <0.001) and greater filling pressures (p <0.001). OW youth also had greater LV mass index (p <0.001), left atrial volume index, and LV interventricular septal thickness (LV-IVS; both p  = 0.02). IR-OW youth had the highest LV filling pressures, LV-IVS, and relative wall thickness (all p <0.05). Homeostasis model of assessment- @entity7 resistance and @entity6 were negative determinants of peak myocardial relaxation velocity and positive predictors of filling pressure. @entity5 was a negative determinant of LV-IVS, independent of @entity1 . In conclusion, OW youth with IR and @entity2 are more likely to have adverse changes to cardiovascular structure and function which may predispose to premature @entity3 in adulthood.

title: Relation of Reduced Preclinical Left Ventricular Diastolic Function and Cardiac Remodeling in Overweight Youth to @entity7 Resistance and XXXX .

answer: @entity2


abstract: UNASSIGNED: Noroviruses are the main cause of severe @entity3 , which results in estimated 200,000 @entity2 each year, primarily in @entity0 in the developing world. Genogroup II.4 (GII.4) strains are responsible for the majority of norovirus outbreaks. Enterovirus 71 (EV71), the leading causative agent of hand, foot @entity4 , has recently been prevalent in Asia-Pacific regions, resulting in significant morbidity and mortality in young @entity0 . However, no vaccine is commercially available for either norovirus GII.4 or EV71. Recombinant virus-like particles (VLPs) derived from either GII.4 or EV71 have been shown to be promising monovalent vaccine candidates. In this study, we investigate the possibility to formulate a VLP-based bivalent vaccine for both norovirus GII.4 and EV71. The GII.4- and EV71-VLPs were produced in a baculovirus-insect cell expression system. A bivalent combination vaccine comprised of GII.4 and EV71 VLPs was formulated and compared with monovalent GII.4- and EV71-VLPs for their immunogenicity in @entity1 . We found that the bivalent vaccine elicited durable antibody responses toward both GII.4 and EV71, and the antibody titers were comparable to that induced by the monovalent vaccines, indicating there is no immunological interference between the two antigens in the combination vaccine. More significantly, the bivalent vaccine-immunized @entity1 sera could efficiently neutralize EV71 infection and block GII.4-VLP binding to mucin. Together, our results demonstrate that the experimental combination vaccine comprised of GII.4 and EV71-VLPs is able to induce a balanced protective antibody response, and therefore strongly support further preclinical and clinical development of such a bivalent VLP vaccine targeting both norovirus GII.4 and EV71.

title: A bivalent virus-like particle based vaccine induces a balanced antibody response against both enterovirus 71 and norovirus in XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity1 may be present at the time type 2 @entity1 is diagnosed, and initial screening encompassing an eye examination performed by an ophthalmologist or optometrist is therefore recommended. However, proper screening for @entity3 may be challenging in many parts of the world. We hypothesized that simple, commonly available @entity0 characteristics can be used to identify @entity0 at high risk for having @entity3 . We investigated data from multiple years extracted from the National Health and Nutrition Examination Survey which holds information about blood @entity2 and eye examinations. Individuals with hitherto undiagnosed @entity1 were classified according to the presence or absence of @entity3 . Linear classification was used to predict which @entity0 had @entity3 at the time of diagnosis. A total of 266 individuals with undiagnosed @entity1 were identified from the cohorts. Of these, 222 individuals had no sign of @entity3 , whereas 44 had mild or moderate @entity3 . Using information regarding HbA1c, BMI, waist circumference, age, systolic blood pressure, urinary albumin, and urinary @entity4 , we were able to construct a model that predicts the presence of @entity3 with a positive predictive value of 22% and a negative predictive value of 99%. Only one true positive (1/44) with mild @entity3 was falsely classified. A classification model using readily available @entity0 information and routine biochemical measures can be used to identify @entity0 at high risk of having @entity3 at the time their @entity1 is diagnosed. The model may be used to identify high-risk @entity0 for @entity3 screening.

title: A classification model for predicting eye disease in newly diagnosed @entity0 with type 2 XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity1 may be present at the time type 2 @entity1 is diagnosed, and initial screening encompassing an eye examination performed by an ophthalmologist or optometrist is therefore recommended. However, proper screening for @entity3 may be challenging in many parts of the world. We hypothesized that simple, commonly available @entity0 characteristics can be used to identify @entity0 at high risk for having @entity3 . We investigated data from multiple years extracted from the National Health and Nutrition Examination Survey which holds information about blood @entity2 and eye examinations. Individuals with hitherto undiagnosed @entity1 were classified according to the presence or absence of @entity3 . Linear classification was used to predict which @entity0 had @entity3 at the time of diagnosis. A total of 266 individuals with undiagnosed @entity1 were identified from the cohorts. Of these, 222 individuals had no sign of @entity3 , whereas 44 had mild or moderate @entity3 . Using information regarding HbA1c, BMI, waist circumference, age, systolic blood pressure, urinary albumin, and urinary @entity4 , we were able to construct a model that predicts the presence of @entity3 with a positive predictive value of 22% and a negative predictive value of 99%. Only one true positive (1/44) with mild @entity3 was falsely classified. A classification model using readily available @entity0 information and routine biochemical measures can be used to identify @entity0 at high risk of having @entity3 at the time their @entity1 is diagnosed. The model may be used to identify high-risk @entity0 for @entity3 screening.

title: A classification model for predicting eye disease in newly diagnosed XXXX with type 2 @entity1 .

answer: @entity0


abstract: BACKGROUND: @entity3 is a frequent finding in critically ill @entity1 @entity0 for whom indications of platelet transfusions are unclear. We herein addressed the current practices in platelet transfusion and the risk of @entity2 in @entity1 @entity0 with hypoproliferative @entity3 in the intensive care unit (ICU). METHODS: A retrospective monocenter study over a 7-year period was conducted in a medical ICU. Adult @entity0 with @entity3 , and who received at least one platelet concentrate during their ICU stay, were included. RESULTS: 296 @entity0 were included and received a total of 904 platelet transfusions, for prophylactic indications in 300 (33.2  %) episodes, for securing an invasive procedure in 257 (28.4  %), and for treatment of minor to major @entity2 manifestations in 347 (38.4  %). Most prophylactic transfusions (80  %) were performed at platelet count thresholds below 10-20  *  10(9)/L. Platelet increments were generally low in all three indications, 10 (interquartile range 2-25), 11 (2-25), and 8 (0-21)  *  10(9)/L, respectively. A total of 97 major ICU-acquired @entity2 events occurred in 40 @entity0 . About half of those @entity2 episodes (54.7  %) occurred at platelet counts below 20  *  10(9)/L. However, neither low admission platelet count nor low nadir platelet counts were predictive of ICU-acquired @entity2 . The in-ICU mortality rate tended to be higher in @entity0 with severe ICU-acquired @entity2 events (50 vs. 36  %). CONCLUSIONS: Most prophylactic platelet transfusions were given using thresholds of 10-20  *  10(9)/L in critically ill @entity1 @entity0 . The individual risk of ICU-acquired severe @entity2 appears hardly predictable with the depth of @entity3 .

title: Platelet transfusions in @entity1 @entity0 with hypoproliferative XXXX in the intensive care unit.

answer: @entity3


abstract: BACKGROUND: @entity3 is a frequent finding in critically ill @entity1 @entity0 for whom indications of platelet transfusions are unclear. We herein addressed the current practices in platelet transfusion and the risk of @entity2 in @entity1 @entity0 with hypoproliferative @entity3 in the intensive care unit (ICU). METHODS: A retrospective monocenter study over a 7-year period was conducted in a medical ICU. Adult @entity0 with @entity3 , and who received at least one platelet concentrate during their ICU stay, were included. RESULTS: 296 @entity0 were included and received a total of 904 platelet transfusions, for prophylactic indications in 300 (33.2  %) episodes, for securing an invasive procedure in 257 (28.4  %), and for treatment of minor to major @entity2 manifestations in 347 (38.4  %). Most prophylactic transfusions (80  %) were performed at platelet count thresholds below 10-20  *  10(9)/L. Platelet increments were generally low in all three indications, 10 (interquartile range 2-25), 11 (2-25), and 8 (0-21)  *  10(9)/L, respectively. A total of 97 major ICU-acquired @entity2 events occurred in 40 @entity0 . About half of those @entity2 episodes (54.7  %) occurred at platelet counts below 20  *  10(9)/L. However, neither low admission platelet count nor low nadir platelet counts were predictive of ICU-acquired @entity2 . The in-ICU mortality rate tended to be higher in @entity0 with severe ICU-acquired @entity2 events (50 vs. 36  %). CONCLUSIONS: Most prophylactic platelet transfusions were given using thresholds of 10-20  *  10(9)/L in critically ill @entity1 @entity0 . The individual risk of ICU-acquired severe @entity2 appears hardly predictable with the depth of @entity3 .

title: Platelet transfusions in XXXX @entity0 with hypoproliferative @entity3 in the intensive care unit.

answer: @entity1


abstract: BACKGROUND: @entity3 is a frequent finding in critically ill @entity1 @entity0 for whom indications of platelet transfusions are unclear. We herein addressed the current practices in platelet transfusion and the risk of @entity2 in @entity1 @entity0 with hypoproliferative @entity3 in the intensive care unit (ICU). METHODS: A retrospective monocenter study over a 7-year period was conducted in a medical ICU. Adult @entity0 with @entity3 , and who received at least one platelet concentrate during their ICU stay, were included. RESULTS: 296 @entity0 were included and received a total of 904 platelet transfusions, for prophylactic indications in 300 (33.2  %) episodes, for securing an invasive procedure in 257 (28.4  %), and for treatment of minor to major @entity2 manifestations in 347 (38.4  %). Most prophylactic transfusions (80  %) were performed at platelet count thresholds below 10-20  *  10(9)/L. Platelet increments were generally low in all three indications, 10 (interquartile range 2-25), 11 (2-25), and 8 (0-21)  *  10(9)/L, respectively. A total of 97 major ICU-acquired @entity2 events occurred in 40 @entity0 . About half of those @entity2 episodes (54.7  %) occurred at platelet counts below 20  *  10(9)/L. However, neither low admission platelet count nor low nadir platelet counts were predictive of ICU-acquired @entity2 . The in-ICU mortality rate tended to be higher in @entity0 with severe ICU-acquired @entity2 events (50 vs. 36  %). CONCLUSIONS: Most prophylactic platelet transfusions were given using thresholds of 10-20  *  10(9)/L in critically ill @entity1 @entity0 . The individual risk of ICU-acquired severe @entity2 appears hardly predictable with the depth of @entity3 .

title: Platelet transfusions in @entity1 XXXX with hypoproliferative @entity3 in the intensive care unit.

answer: @entity0


abstract: UNASSIGNED: @entity4 is a food-borne @entity5 induced by the @entity3 @entity6 , and has been recognized as the main cause leading to @entity0 @entity2 . @entity0 usually acquire @entity1 by digestion of infected Pomacea canaliculata and Achatina fulica, the most predominant intermediate hosts found in China. This meta-analysis was aimed to assess the prevalence of A. cantonensis @entity1 among these two snails in China in the past 10  years. Data were systematically collected in electronic databases such as PubMed, Web of Science, ScienceDirect, CNKI, SinoMed, VIP, CSCD, and Wanfang from 2005 to 2015. Thirty-eight studies with a total of 41,299 P. canaliculata and 21,138 Ac. fulica were included in the present study. The overall @entity1 rate of A. cantonensis in China was estimated to be 7.6  % (95  % confidential interval (CI)   =   0.063 to 0.090) in P. canaliculata and 21.5  % in Ac. fulica (95  % CI   =   0.184 to 0.245), respectively. No significant difference was observed in prevalence rates among publication year and sample size for both snails. Also, it was found that the prevalence in Ac. fulica is significantly higher than that in P. canaliculata (odds ratio (OR)   =   3.946, 95  % CI   =   3.070 to 5.073). The present study reveals that snail @entity1 with A. cantonensis is clearly prevalent in China. Further studies are required to improve strategies for control of @entity1 , particularly those of Ac. fulica, and to detect further factors and conditions such as geographic region, temperatures, and diagnosis method.

title: XXXX in the vector snails Pomacea canaliculata and Achatina fulica in China: a meta-analysis.

answer: @entity6


abstract: BACKGROUND: @entity3 is a chronic inflammatory process involving the immune system and formation of reactive @entity1 species (ROS). We investigated changes of mononuclear blood cells and ROS production in relation to the walking distance of @entity0 with @entity2 during home-based exercise training. METHODS: Forty @entity0 with @entity2 were asked to perform a home-based exercise training for a mean time of 12  months. ROS formation was measured using the @entity11 analogue @entity14 . Peripheral blood leucocytes [monocytes, polymorphonuclear neutrophils (PMN) and dendritic cells (DC)] were analysed by flow cytometry and analysed for the expression of major inflammatory surface molecules. RESULTS: At follow-up, @entity0 showed an increased walking distance and reduced ROS production upon stimulation with a @entity9 derivative (PDBu) (p  <  0.01). Monocytes changed their inflammatory phenotype towards an increased anti-inflammatory @entity10 (++) @entity8 (-) subpopulation (p  <  0.0001). Adhesion molecules @entity12 , @entity5 and @entity13 on monocytes and PMN decreased (all p  <  0.01). On DC expression of HLA-DR, @entity7 or @entity6 decreased at follow-up. Inflammatory markers like @entity4 , C-reactive protein or soluble @entity13 (sTREM-1) decreased over the observation period. Finally, we found a close relation of sTREM-1 with the walking distance, @entity4 and ROS production. CONCLUSIONS: We observed an amelioration of the proinflammatory phenotype on monocytes, DC and PMN, as well as a reduced ROS production in PAD @entity0 under home-based exercise, paralleled by an increased walking distance. Our data suggest that a reduced inflammatory state might be achieved by regular walking exercise, possibly in a dimension proportionately to changes in walking distance.

title: Change of walking distance in XXXX : impact on inflammation, oxidative stress and mononuclear cells: a pilot study.

answer: @entity2


abstract: PURPOSE: @entity5 is common after cardiac surgery and is associated with adverse consequences, including @entity2 . Identification of vulnerable older adults might allow for early implementation of @entity5 -prevention strategies. Brain MRI findings provide insight into structural brain changes that may identify vulnerable @entity0 . The purpose of this study was to examine the association between brain MRI characteristics potentially associated with @entity5 vulnerability and the development of @entity4 in a nested cohort of @entity0 undergoing cardiac surgery. METHODS: We identified 79 cardiac surgery @entity0 who had brain MRI imaging after cardiac surgery, as part of an ongoing randomized trial evaluating the efficacy of blood pressure management based on cerebral autoregulation monitoring versus standard management for improving neurological outcomes. Cerebral lateral ventricular size, cortical sulcal width, and @entity1 ( @entity1 ) on brain MRI scans were graded on a validated 0 to 9 scale, and categorized into tertiles. New @entity6 were characterized as present or absent. @entity5 was assessed using a validated chart-review. Neuropsychological testing performed before surgery was used to establish preoperative cognitive baseline. Multivariable logistic regression was used to assess the independent association between MRI characteristics and @entity4 . FINDINGS: The average age of @entity0 was 70.1    7.8 years old, and 72% were male. Twenty-eight of 79 (35.4%) @entity0 developed @entity4 . @entity0 with @entity5 had higher unadjusted ventricular size (median 4 vs. 3, P = 0.003), and there was a trend towards higher sulcal sizes and @entity1 grades. Increasing tertiles of ventricular size (Odds Ratio [OR] 3.59; 95% Confidence Interval [CI] 1.59-8.12; P = 0.002) and sulcal size (OR 2.15; 95%CI 1.13-4.12; P = 0.02) were associated with @entity4 , with a trend for tertiles of @entity1 grade (OR 1.91; 95%CI 0.99-3.68; P = 0.05). In multivariable models adjusted for logistic EuroSCORE, baseline cognitive status, bypass time, and any @entity4 , each tertile of ventricular size was associated with increased odds of @entity4 (OR 3.23 per tertile increase in ventricular size; 95%CI 1.21-8.60; P = 0.02). There were no differences in odds of @entity5 by tertiles of sulcal grade, tertiles of white matter grade, or presence of new @entity6 , in adjusted models. IMPLICATIONS: Increased brain ventricular size was independently associated with @entity5 after cardiac surgery. These results suggest that @entity3 may contribute to increased vulnerability for @entity4 . Baseline brain MRIs may be useful in identifying cardiac surgery @entity0 at high risk for @entity4 , who might benefit from targeted perioperative approaches to prevent @entity5 . ClinicalTrials.gov identifier: NCT00981474.

title: The Association of Brain MRI Characteristics and XXXX in Cardiac Surgery @entity0 .

answer: @entity4


abstract: PURPOSE: @entity5 is common after cardiac surgery and is associated with adverse consequences, including @entity2 . Identification of vulnerable older adults might allow for early implementation of @entity5 -prevention strategies. Brain MRI findings provide insight into structural brain changes that may identify vulnerable @entity0 . The purpose of this study was to examine the association between brain MRI characteristics potentially associated with @entity5 vulnerability and the development of @entity4 in a nested cohort of @entity0 undergoing cardiac surgery. METHODS: We identified 79 cardiac surgery @entity0 who had brain MRI imaging after cardiac surgery, as part of an ongoing randomized trial evaluating the efficacy of blood pressure management based on cerebral autoregulation monitoring versus standard management for improving neurological outcomes. Cerebral lateral ventricular size, cortical sulcal width, and @entity1 ( @entity1 ) on brain MRI scans were graded on a validated 0 to 9 scale, and categorized into tertiles. New @entity6 were characterized as present or absent. @entity5 was assessed using a validated chart-review. Neuropsychological testing performed before surgery was used to establish preoperative cognitive baseline. Multivariable logistic regression was used to assess the independent association between MRI characteristics and @entity4 . FINDINGS: The average age of @entity0 was 70.1    7.8 years old, and 72% were male. Twenty-eight of 79 (35.4%) @entity0 developed @entity4 . @entity0 with @entity5 had higher unadjusted ventricular size (median 4 vs. 3, P = 0.003), and there was a trend towards higher sulcal sizes and @entity1 grades. Increasing tertiles of ventricular size (Odds Ratio [OR] 3.59; 95% Confidence Interval [CI] 1.59-8.12; P = 0.002) and sulcal size (OR 2.15; 95%CI 1.13-4.12; P = 0.02) were associated with @entity4 , with a trend for tertiles of @entity1 grade (OR 1.91; 95%CI 0.99-3.68; P = 0.05). In multivariable models adjusted for logistic EuroSCORE, baseline cognitive status, bypass time, and any @entity4 , each tertile of ventricular size was associated with increased odds of @entity4 (OR 3.23 per tertile increase in ventricular size; 95%CI 1.21-8.60; P = 0.02). There were no differences in odds of @entity5 by tertiles of sulcal grade, tertiles of white matter grade, or presence of new @entity6 , in adjusted models. IMPLICATIONS: Increased brain ventricular size was independently associated with @entity5 after cardiac surgery. These results suggest that @entity3 may contribute to increased vulnerability for @entity4 . Baseline brain MRIs may be useful in identifying cardiac surgery @entity0 at high risk for @entity4 , who might benefit from targeted perioperative approaches to prevent @entity5 . ClinicalTrials.gov identifier: NCT00981474.

title: The Association of Brain MRI Characteristics and @entity4 in Cardiac Surgery XXXX .

answer: @entity0


abstract: OBJECTIVE: Clinical studies of @entity0 with @entity2 have been challenged by insufficient numbers at individual centres to draw valid conclusions. Our objective was to assess the feasibility of conducting a definitive multi-centre randomised controlled trial (RCT) to determine whether a five-day regimen of post-operative antibiotics, in comparison to a 24-hour regimen, decreases surgical site infections in @entity0 undergoing endoprosthetic reconstruction for lower extremity primary @entity1 . METHODS: We performed a pilot international multi-centre RCT. We used central randomisation to conceal treatment allocation and sham antibiotics to blind @entity0 , surgeons, and data collectors. We determined feasibility by measuring @entity0 enrolment, completeness of follow-up, and protocol deviations for the antibiotic regimens. RESULTS: We screened 96 @entity0 and enrolled 60 @entity0 (44 @entity0 and 16 @entity0 ) across 21 sites from four countries over 24 months (mean 2.13 @entity0 per site per year, standard deviation 2.14). One @entity0 was lost to follow-up and one withdrew consent. Complete data were obtained for 98% of eligible @entity0 at two weeks, 83% at six months, and 73% at one year (the remainder with partial data or pending queries). In total, 18 @entity0 missed at least one dose of antibiotics or placebo post-operatively, but 93% of all post-operative doses were administered per protocol. CONCLUSIONS: It is feasible to conduct a definitive multi-centre RCT of post-operative antibiotic regimens in @entity0 with @entity2 , but further expansion of our collaborative network will be critical. We have demonstrated an ability to coordinate in multiple countries, enrol @entity0 , maintain protocol adherence, and minimise losses to follow-up. Cite this article: Bone Joint Res;4:154-162.

title: Prophylactic antibiotic regimens in XXXX surgery (PARITY): a pilot multicentre randomised controlled trial.

answer: @entity1


abstract: OBJECTIVE: To investigate the effect of hormonal androgenic treatment on antim  llerian hormone ( @entity1 ) serum levels in female-to-male (FtM) transsexual @entity0 . @entity7 ( @entity7 ) is associated with elevated @entity1 levels. Some hypothesize that the high @entity1 level is a consequence of @entity3 -induced excessive development of small antral follicles. However, this role of @entity8 is not yet clear. DESIGN: Observational, prospective, cohort study. SETTING: Tertiary academic medical center. @entity0 (S): Twenty-two FtM transsexual @entity0 , healthy native females receiving cross-sex hormone therapy/androgenic treatment. INTERVENTION(S): Androgenic treatment with @entity2 (T) and an aromatase inhibitor while endogenous hormone secretion was suppressed with the use of a GnRH agonist. MAIN OUTCOME MEASURE(S): @entity9 concentrations were measured before and after androgenic treatment (administration of T and aromatase inhibitor). Measured hormones: @entity1 , inhibin B, T, @entity5 , @entity6 , E2, @entity4 , LH, and FSH. RESULT(S): @entity1 concentrations were significantly lower after androgenic treatment (4.4    4.4   g/L vs. 1.4    2.1   g/L). Androgenic treatment resulted in a strong suppression of @entity1 secretion over a relative short period of 16  weeks. CONCLUSION(S): Our data underscore the likely important role of @entity8 in the dynamics of folliculogenesis. It challenges the idea that @entity8 induce high @entity1 levels, which is gaining more interest nowadays as an important particular @entity7 feature. This strong decline furthermore indicates that @entity1 must be interpreted in the context of other reproductive endocrine conditions. CLINICAL TRIAL REGISTRATION NUMBER: NTR2493.

title: Antim  llerian hormone levels decrease in female-to-male transsexual @entity0 using XXXX as cross-sex therapy.

answer: @entity2


abstract: OBJECTIVE: To investigate the effect of hormonal androgenic treatment on antim  llerian hormone ( @entity1 ) serum levels in female-to-male (FtM) transsexual @entity0 . @entity7 ( @entity7 ) is associated with elevated @entity1 levels. Some hypothesize that the high @entity1 level is a consequence of @entity3 -induced excessive development of small antral follicles. However, this role of @entity8 is not yet clear. DESIGN: Observational, prospective, cohort study. SETTING: Tertiary academic medical center. @entity0 (S): Twenty-two FtM transsexual @entity0 , healthy native females receiving cross-sex hormone therapy/androgenic treatment. INTERVENTION(S): Androgenic treatment with @entity2 (T) and an aromatase inhibitor while endogenous hormone secretion was suppressed with the use of a GnRH agonist. MAIN OUTCOME MEASURE(S): @entity9 concentrations were measured before and after androgenic treatment (administration of T and aromatase inhibitor). Measured hormones: @entity1 , inhibin B, T, @entity5 , @entity6 , E2, @entity4 , LH, and FSH. RESULT(S): @entity1 concentrations were significantly lower after androgenic treatment (4.4    4.4   g/L vs. 1.4    2.1   g/L). Androgenic treatment resulted in a strong suppression of @entity1 secretion over a relative short period of 16  weeks. CONCLUSION(S): Our data underscore the likely important role of @entity8 in the dynamics of folliculogenesis. It challenges the idea that @entity8 induce high @entity1 levels, which is gaining more interest nowadays as an important particular @entity7 feature. This strong decline furthermore indicates that @entity1 must be interpreted in the context of other reproductive endocrine conditions. CLINICAL TRIAL REGISTRATION NUMBER: NTR2493.

title: Antim  llerian hormone levels decrease in female-to-male transsexual XXXX using @entity2 as cross-sex therapy.

answer: @entity0


abstract: UNASSIGNED: @entity1 can be viewed as an early manifestation of @entity3 . Environmental exposures including @entity0 , diet, nutrient balance, microbial colonisation and toxin exposures can directly and indirectly influence immune programming in both pregnancy and the postnatal period. The intrauterine microclimate is critical for @entity3 to sustain viable pregnancy, but appears susceptible to environmental conditions. Targeting aspects of the modern environment that promote aberrant patterns of immune response is logical for interventions aimed at primary prevention of @entity1 . Defining the mechanisms that underpin both natural and therapeutic acquisition of @entity3 in childhood will provide insights into the drivers of persistent @entity3 . In this review we summarise evidence that @entity2 is a consequence of intrauterine and early life @entity3 , with specific focus on contributing environmental risk factors occurring preconception, in utero and in the early postnatal period. We explore the immunological mechanisms which underpin tolerance and persistence of @entity1 during childhood. It is likely that future investigations within these two domains will ultimately provide a road map for the primary prevention of @entity1 . This article is protected by copyright. All rights reserved.

title: Mechanisms of XXXX - Environmental and genetic determinants for the development of @entity2 .

answer: @entity1


abstract: UNASSIGNED: @entity1 can be viewed as an early manifestation of @entity3 . Environmental exposures including @entity0 , diet, nutrient balance, microbial colonisation and toxin exposures can directly and indirectly influence immune programming in both pregnancy and the postnatal period. The intrauterine microclimate is critical for @entity3 to sustain viable pregnancy, but appears susceptible to environmental conditions. Targeting aspects of the modern environment that promote aberrant patterns of immune response is logical for interventions aimed at primary prevention of @entity1 . Defining the mechanisms that underpin both natural and therapeutic acquisition of @entity3 in childhood will provide insights into the drivers of persistent @entity3 . In this review we summarise evidence that @entity2 is a consequence of intrauterine and early life @entity3 , with specific focus on contributing environmental risk factors occurring preconception, in utero and in the early postnatal period. We explore the immunological mechanisms which underpin tolerance and persistence of @entity1 during childhood. It is likely that future investigations within these two domains will ultimately provide a road map for the primary prevention of @entity1 . This article is protected by copyright. All rights reserved.

title: Mechanisms of @entity1 - Environmental and genetic determinants for the development of XXXX .

answer: @entity2


abstract: UNASSIGNED: Low-grade cribriform @entity6 (LGCCC) is a @entity2 . LGCCC occurs rarely, with the parotid gland being the most commonly afflicted site. Few cases arise in other sites. The present study reports a case of LGCCC that occurred at the palatal gland of the hard palate. A 56-year-old female was referred to Saitama Medical University Hospital (Moroyama, Saitama, Japan) due to an intraoral mass. Since cytological examination and biopsy led to a diagnosis favoring a @entity2 , but with uncertain malignant potential, the @entity2 was resected with a safe surgical margin. The specimen was thoroughly examined. Microscopically, there was a well-demarcated, unilocular cyst with the lumen lined by @entity2 cells. The @entity2 cells were arranged in tubular, cribriform and solid structures in the area of the intracystic mass lesions. Nuclear atypia was inconspicuous, although mitotic figures were observed throughout the @entity2 . Neither local nor perineural invasion was present. On immunohistochemistry, the @entity2 cells were diffusely positive for @entity5 protein. Myoepithelial markers, calponin and @entity4 , highlighted the cells rimming the @entity3 . The final histopathological diagnosis was of LGCCC. The @entity2 was completely resected. At 1 year post-resection, the @entity0 exhibited no recurrence or distant @entity1 . LGCCC is regarded as clinically indolent. However, there is little literature available to aid with prognosis prediction due to the rarity of LGCCC cases. Thus, greater experience and longer follow-up periods are necessary to find the optimal/curative treatment for @entity0 with LGCCC and to clarify the pathophysiology.

title: Low-grade cribriform XXXX of the palatal gland: A case report.

answer: @entity6


abstract: Patulin (PAT), a mycotoxin contaminant of apples and apple products, has been implicated in nephrotoxicity. PAT depletes glutathione (GSH) and elevates reactive oxygen species (ROS). The antioxidant (AO) response is activated by Nuclear erythroid 2-related factor ( @entity5 ) and enhanced by @entity7 ( @entity7 ). The effects of PAT on these molecules have yet to be examined. We investigated the effects of PAT on AO response survival pathways in @entity0 embryonic kidney cells (HEK293). PAT @entity1 on HEK293 cells was evaluated (MTT assay; 24  h; [0-100   M]) to determine an IC50. GSH levels were measured using luminometry. Intracellular ROS was evaluated by flow cytometry. Protein expression of @entity6 , @entity5 , @entity7 and @entity4 was quantified by western blotting and gene expression of @entity3 , @entity2 was evaluated by qPCR. PAT caused a dose dependent decrease in HEK293 cell viability and a significant increase in levels of intracellular ROS (p  =  0.0006). A significant increase in protein expression (p  =  0.029) was observed. PAT increased gene expression of @entity3 and @entity2 (p  =  0.0043), however, gene expression of GPx was significantly reduced (p  =  0.0043). These results show the up-regulation of @entity5 mediated AO mechanisms in response to PAT @entity1 .

title: Patulin triggers XXXX -mediated survival mechanisms in kidney cells.

answer: @entity5


abstract: BACKGROUND AND OBJECTIVES: The main cause of serious @entity2 is a Gram-negative pathogen known as @entity3 ( @entity3 ). Carbapenems are widely used as an appropriate treatment for these @entity1 , however resistance to these agents has been observed and is increasing. Metallo beta-lactamase (MBLs) enzyme is one of the main causes of resistance to @entity5 . In the current study the frequency and production of VIM1 and @entity6 by @entity4 -resistant @entity3 isolates of @entity0 hospitalized in Imam Reza hospital were evaluated. MATERIALS AND METHODS: In this study, 131 clinical samples were collected from @entity0 hospitalized in Imam Reza hospital in Mashhad during a 15-month period from May 2011 to November 2012. After verification of P. aeruginosa isolates, antibiotic resistance patterns of isolates were determined for 14 antibiotics by Kirby-Bauer standard disk diffusion according to the CLSI guidelines. Combined-disk test was used for phenotypic determination of MBLs-producing isolates and after DNA extraction, genotypic determination of VIM1 and @entity6 metallo beta-lactamase genes was carried out using Multiplex-PCR. RESULTS: Of 63 @entity4 -resistant isolates (48.5%), 56 (88.8%) were MBL-producing in phenotypic assessments. Also amongst @entity4 -resistant isolates, the frequency of VIM1 and @entity6 genes were 58.7 and 3.17%, respectively. CONCLUSION: The results of the current study along with the results of the other conducted studies in Iran in recent years demonstrate that the average resistance to @entity4 in @entity3 isolates was 51.3% which has increased in comparison with the results in 2006 (32.9%). It was also determined that the frequency of VIM1 gene was more than @entity6 gene. In phenotypic assessment by using CD method, 49.6% of isolates were determined as MBLs-producing. The sensitivity and specificity of this method were verified in comparison with the results of PCR test.

title: Study on XXXX resistance and prevalence of blaVIM1 and blaVIM2 metallo-beta lactamases among clinical isolates of @entity3 from Mashhad, Northeast of Iran.

answer: @entity4


abstract: BACKGROUND AND OBJECTIVES: The main cause of serious @entity2 is a Gram-negative pathogen known as @entity3 ( @entity3 ). Carbapenems are widely used as an appropriate treatment for these @entity1 , however resistance to these agents has been observed and is increasing. Metallo beta-lactamase (MBLs) enzyme is one of the main causes of resistance to @entity5 . In the current study the frequency and production of VIM1 and @entity6 by @entity4 -resistant @entity3 isolates of @entity0 hospitalized in Imam Reza hospital were evaluated. MATERIALS AND METHODS: In this study, 131 clinical samples were collected from @entity0 hospitalized in Imam Reza hospital in Mashhad during a 15-month period from May 2011 to November 2012. After verification of P. aeruginosa isolates, antibiotic resistance patterns of isolates were determined for 14 antibiotics by Kirby-Bauer standard disk diffusion according to the CLSI guidelines. Combined-disk test was used for phenotypic determination of MBLs-producing isolates and after DNA extraction, genotypic determination of VIM1 and @entity6 metallo beta-lactamase genes was carried out using Multiplex-PCR. RESULTS: Of 63 @entity4 -resistant isolates (48.5%), 56 (88.8%) were MBL-producing in phenotypic assessments. Also amongst @entity4 -resistant isolates, the frequency of VIM1 and @entity6 genes were 58.7 and 3.17%, respectively. CONCLUSION: The results of the current study along with the results of the other conducted studies in Iran in recent years demonstrate that the average resistance to @entity4 in @entity3 isolates was 51.3% which has increased in comparison with the results in 2006 (32.9%). It was also determined that the frequency of VIM1 gene was more than @entity6 gene. In phenotypic assessment by using CD method, 49.6% of isolates were determined as MBLs-producing. The sensitivity and specificity of this method were verified in comparison with the results of PCR test.

title: Study on @entity4 resistance and prevalence of blaVIM1 and blaVIM2 metallo-beta lactamases among clinical isolates of XXXX from Mashhad, Northeast of Iran.

answer: @entity3


abstract: UNASSIGNED: During the last decades, @entity0 and @entity1 have become important global health problems, and the belief that @entity0 is protective against @entity1 has recently come into question. In fact, some recent epidemiologic and clinical studies have shown that a high level of fat mass might be a risk factor for @entity1 and @entity3 . Several potential mechanisms have been proposed to explain the complex relationship between adipose tissue and bone. Indeed, adipose tissue secretes various molecules, named adipokines, which are thought to have effects on metabolic, skeletal and cardiovascular systems. Moreover, fat tissue is one of the major sources of aromatase, an enzyme that synthesizes @entity2 from @entity4 precursors, hormones that play a pivotal role in the maintenance of skeletal homeostasis, protecting against @entity1 . Moreover, bone cells express several specific hormone receptors and recent observations have shown that bone-derived factors, such as osteocalcin and @entity6 , affect body weight control and @entity5 homeostasis. Thus, the skeleton is considered an endocrine target organ and an endocrine organ itself, likely influencing other organs as well. Finally, adipocytes and osteoblasts originate from a common progenitor, a pluripotential mesenchymal stem cell, which has an equal propensity for differentiation into adipocytes or osteoblasts (or other lines) under the influence of several cell-derived transcription factors. This review will highlight recent insights into the relationship between fat and bone, evaluating both potential positive and negative influences between adipose and bone tissue. It will also focus on the hypothesis that @entity1 might be considered the @entity0 of bone.

title: The XXXX of bone.

answer: @entity0


abstract: OBJECTIVES: Valid screening tools are needed to identify Indian @entity0 and adolescents with mental health problems, both for clinical or research purposes. The present study validated the Strengths and Difficulties Questionnaire (SDQ) in Malayalam across different informants and sub-scales. METHODS: A sample of 150 @entity0 and adolescents seen in a @entity1 clinic for @entity0 in Kerala, India was compared to a community sample of 1984 @entity0 from six surrounding urban and rural districts. @entity0 in clinic and community samples were screened with the parent-report SDQ; those over 11 y completed the self-report SDQ. The community sample was also screened with the teacher-report SDQ and the clinical sample received formal diagnoses from a @entity0 psychiatrist blind to SDQ scores. The discriminative validity of the SDQ was investigated using Receiver Operator Characteristic (ROC) curves and by assessing Area Under the Curve (AUC). RESULTS: The SDQ discriminated reliably between clinical and community samples for the SDQ total score and its subscales. Within the clinic sample, 49  % of @entity0 qualified for more than one broad diagnostic grouping. The SDQ discriminated between diagnostic categories in the clinic sample, but did so most effectively for @entity2 . Based on the cut-offs that generated the highest combined value of sensitivity and specificity, the estimated rate of @entity1 in the community sample was 13.6  % (parent-report) and 7.3  % (self-report). CONCLUSIONS: The SDQ is a useful screening tool for @entity0 and @entity1 for Malayalam speakers in Kerala, India.

title: Validating Screening Tool in Malayalam for XXXX .

answer: @entity1


abstract: In most cases of @entity3 , demyelinization processes on the nerve lead to considerable decreases in the nerve conduction velocity. It has up to now been possible to substantiate the therapeutic success of neurotropic vitamins only by more or less subjective parameters obtained from numerous studies. In the present investigation of 33 diabetics with @entity2 it was possible to show that the nerve conduction velocity is a parameter which can be measured objectively for the monitoring of the development of @entity1 . The increases in the nerve conduction velocity, which had decreased prior to the beginning of treatment, coincided closely with clinical evaluations. The therapeutic use of Neurobion was assessed on the basis of this criterion. The dosage plan for hospitalized @entity0 differed from that for outpatients. In the case of inpatients who received high doses of vitamins, it was possible to substantiate the effect of Neurobion significantly in statistical terms by means of the corresponding increases in the nerve conduction velocity. There were different therapeutic results in both groups of @entity0 . The outpatients receiving smaller single doses as well as a smaller total dose of Neurobion could not be treated as successfully as the inpatient. This dose effect that is apparent must be substantiated by further investigations in this area.

title: Influence of neurotropic vitamins on the nerve conduction velocity in XXXX .

answer: @entity3


abstract: INTRODUCTION: To describe the unique MRI findings of superior cervical ganglia (SCG) that may help differentiate them from retropharyngeal lymph nodes (RPLNs). METHODS: A retrospective review of post-treatment @entity4 @entity0 from 1999 to 2012 identified three @entity0 previously irradiated for @entity4 that were suspected of having recurrent @entity1 in retropharyngeal lymph nodes during surveillance MRI. Subsequent surgical exploration revealed enlarged SCG only; no retropharyngeal @entity1 was found. A cadaveric head specimen was also imaged with a 3T MRI before and after dissection. In addition, SCG were also harvested from three cadaveric specimens and subjected to histologic analysis. RESULTS: The SCG were found at the level of the C2 vertebral body, medial to the @entity3 . They were ovoid on axial images and fusiform and elongated with tapered margins in the coronal plane. T2-weighted (T2W) signal was hyperintense. No central elevated T1-weighted (T1W) signal was seen within the ganglia in non-fat-saturated sequences to suggest the presence of a fatty hilum. Enhancement after @entity2 was present. A central "black dot" was seen on axial T2W and post-contrast images in two of the three SCG demonstrated. Histology showed the central black line was comprised of venules and interlacing neurites within the central portion of the ganglion. CONCLUSIONS: The SCG can be mistaken for enlarged RPLNs in post-treatment @entity4 @entity0 . However, there are features which can help differentiate them from RPLNs, preventing unnecessary therapy. These imaging findings have not been previously described.

title: Superior cervical ganglion mimicking retropharyngeal adenopathy in head and neck cancer XXXX : MRI features with anatomic, histologic, and surgical correlation.

answer: @entity0


abstract: UNASSIGNED: @entity2 ( @entity2 ) is the most common form of @entity3 in the elderly. The recent evidence in @entity2 research suggests that alterations in the microRNA (miRNA) could contribute to risk for the disease. However, little is understood about the roles of miRNAs in @entity1 of early @entity2 ( @entity2 ). Here, we used 5-month-old APP/ @entity4 @entity0 , which mimic many of the salient features of the early stage of @entity2 pathological process, to further investigate the roles of miRNAs in synaptic loss involved in learning and memory. We used miRNA expression microarrays on RNA extracted from the hippocampus of 5-month-old APP/ @entity4 @entity0 and wild type @entity0 . Real-time reverse transcription PCR was conducted to verify the candidate miRNAs discovered by microarray analysis. The data showed that @entity5 was increased significantly in the hippocampus of 5-month-old APP/ @entity4 @entity0 , which were concomitant with that APP/ @entity4 @entity0 at the same age displayed a significant synaptic loss and @entity1 . Bioinformatic analysis predicted that neuritin ( @entity6 ) mRNA is targeted by @entity5 . Overexpression of @entity5 lowers the levels of neuritin and synaptic proteins expression in primary hippocampal neurons damage induced by Ab25-35. And the expression of @entity5 was also up-regulated in the hippocampal neurons from APP/ @entity4 @entity0 compared with WT littermates. In contrast, suppression of @entity5 by @entity5 inhibitor significantly results in higher levels of neuritin and synaptic proteins expression. Taken together, @entity5 is involved in @entity1 in 5-month-old APP/ @entity4 @entity0 through regulation of neuritin.

title: MicroRNA-574 is involved in XXXX in 5-month-old APP/ @entity4 @entity0 through regulation of neuritin.

answer: @entity1