abstract: UNASSIGNED: A 12 yr old castrated male domestic longhair underwent renal transplantation for treatment of chronic @entity7 . Full-thickness intestinal biopsies obtained prior to transplantation revealed mild @entity6 . Twelve months following transplantation, the @entity0 underwent surgery for resection of a mesenteric mass causing @entity3 . The mesenteric mass was resected and an intestinal resection and @entity1 was performed. Extended-spectrum-b-lactamase producing @entity9 was cultured from the resected tissue and urinary tract. Bacterial rods were noted to be circulating in the bloodstream, causing @entity2 . Despite aggressive treatment of the @entity3 and @entity2 using surgical debridement, drain placement, aggressive antibiotic therapy with IV meropenem, and vasopressor support, the @entity0 succumbed to persistent @entity4 and suffered @entity5 . Extended-spectrum-b-lactamase-producing bacteria are of growing concern in @entity0 and veterinary medicine, maintaining susceptibility often only to @entity8 and @entity10 antibiotics. Resistance to even those antibiotics is emerging. Veterinary @entity0 with a history of antibiotic therapy, central venous or urinary catheterization, immunosuppression, enteric surgery, and an extended stay in the intensive care unit may be predisposed.

title: @entity2 and Infection due to ESBL-producing XXXX Following Feline Renal Allograft Transplantation.

answer: @entity9


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Propolis has been used as a folk medicine for centuries around the world due to its wide spectrum of biological activities. The red propolis, a new Brazilian variety of this apimaterial, has presented an unusual chemical composition, including @entity8 such as @entity9 and @entity10 . Since both the green and red varieties of propolis are traditionally used as medicine and commercialized with no label differentiation, the study of the activities of red propolis extract has become important in order to clarify whether this product has the same activities as commercial ones. In this work, we demonstrated the potential action of the @entity6 ( @entity6 ) and its biomarker, @entity9 , as antinociceptive and anti-inflammatory drugs on experimental models. MATERIALS AND METHODS: The @entity6 was chemically characterised by HPLC/DAD analyses. The biological activities of the @entity6 (3, 10, and 30mg/kg) and @entity9 (10mg/kg) were evaluated using the antinociceptive ( @entity5 , @entity4 , and @entity7 injections) and anti-inflammatory (carrageenan-induced hindpaw @entity0 and @entity3 ) models in @entity1 after oral administration. The open field test was also performed. RESULTS: @entity9 , one of the main biomarker of red propolis, was identified in the @entity6 (21.62mg/g). Pretreatment with the @entity6 (10 and 30mg/kg) and @entity9 (10mg/kg) produced reduction (P<0.001) in the number of abdominal writhes, but the @entity6 was more effective (P<0.001) than @entity9 . In the @entity4 test, all @entity6 doses (3, 10, and 30mg/kg, P<0.001) inhibited the late phase ( @entity2 ) of @entity4 -induced licking, but the @entity2 was observed only when the higher doses (10 and 30mg/kg; P<0.05) were used. @entity9 caused inhibition (P<0.001) only in the second phase of @entity4 -induced nociception similarly at all @entity6 doses in the same phase of the test. The responses in @entity7 -induced model presented crescent inhibition (P<0.05) with 10 and 30mg/kg of @entity6 . Also, @entity9 inhibited (P<0.001) the nociception induced by @entity7 similarly to 30mg/kg of @entity6 . There were no significant differences in the open field test after @entity6 administration, but @entity9 decrease the spontaneous motor behaviour. Regarding the anti-inflammatory assessment, the @entity6 (10 and 30mg/kg, P<0.05) and @entity9 (P<0.001) treatments caused a significant inhibition of the @entity0 response. All doses of @entity6 (3, 10, and 30mg/kg, P<0.05) and @entity9 (P<0.001) also inhibited the carrageenan-induced leukocyte migration. In both cases, the results for the @entity6 at 30mg/kg and @entity9 were similar. CONCLUSIONS: The @entity6 and @entity9 presented significant anti-inflammatory activity. Moreover, the @entity6 presented antinociceptive action on inflammatory and @entity2 without motor side effects, possibly due to the action of other constituents present in the extract. These results, together, support the popular usage of this natural product.

title: Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and XXXX in rodents.

answer: @entity9


abstract: Fifty-eight @entity0 underwent unilateral vertebral arterial reconstructions over a 16-year period. Thirty-four underwent carotid operations as well. The first 18 @entity0 underwent vertebral arterial reconstructions in conjunction with carotid endarterectomy as mandated in the Joint Study of Extracranial @entity6 as a Cause of Stoke. The next 40 underwent vertebral procedures for either brain stem symptoms alone, or for combined cerebral cortical and stem symptoms for specific indications after @entity3 had been corrected, but symptoms failed to subside. The surgical procedure consisted of subclavian- @entity12 except in one @entity0 who underwent a subclavian distal-vertebral bypass graft to the level of the second cervical vertebral body. @entity10 occurred as a major symptom in 16 and was controlled by either carotid and vertebral or vertebral artery operation alone except in four who also required cardiac pacemakers and one who needed correction of @entity7 . The long-term follow-up reveals that the @entity2 rate per average year for the first 14 years of follow-up was 1.2% per @entity0 year with only five @entity2 having occurred in 410 @entity0 years of follow-up and 70% of the @entity0 having sustained no new @entity1 at the fourteenth year. Survival, however, was 45% at the fourteenth year with most @entity4 caused by @entity8 . The surgical procedure of @entity12 is indicated when bilateral vertebral arterial flow-obstructing lesions are found in @entity0 with @entity11 including @entity10 and @entity10 if @entity3 have been corrected and symptoms persist. The surgical procedure can be performed with a high degree of safety. The differential diagnosis of @entity10 and @entity10 in this age group should include, in @entity13 , transient @entity9 , @entity7 , and @entity5 .

title: Cervical XXXX for @entity11 .

answer: @entity12


abstract: Fifty-eight @entity0 underwent unilateral vertebral arterial reconstructions over a 16-year period. Thirty-four underwent carotid operations as well. The first 18 @entity0 underwent vertebral arterial reconstructions in conjunction with carotid endarterectomy as mandated in the Joint Study of Extracranial @entity6 as a Cause of Stoke. The next 40 underwent vertebral procedures for either brain stem symptoms alone, or for combined cerebral cortical and stem symptoms for specific indications after @entity3 had been corrected, but symptoms failed to subside. The surgical procedure consisted of subclavian- @entity12 except in one @entity0 who underwent a subclavian distal-vertebral bypass graft to the level of the second cervical vertebral body. @entity10 occurred as a major symptom in 16 and was controlled by either carotid and vertebral or vertebral artery operation alone except in four who also required cardiac pacemakers and one who needed correction of @entity7 . The long-term follow-up reveals that the @entity2 rate per average year for the first 14 years of follow-up was 1.2% per @entity0 year with only five @entity2 having occurred in 410 @entity0 years of follow-up and 70% of the @entity0 having sustained no new @entity1 at the fourteenth year. Survival, however, was 45% at the fourteenth year with most @entity4 caused by @entity8 . The surgical procedure of @entity12 is indicated when bilateral vertebral arterial flow-obstructing lesions are found in @entity0 with @entity11 including @entity10 and @entity10 if @entity3 have been corrected and symptoms persist. The surgical procedure can be performed with a high degree of safety. The differential diagnosis of @entity10 and @entity10 in this age group should include, in @entity13 , transient @entity9 , @entity7 , and @entity5 .

title: Cervical @entity12 for XXXX .

answer: @entity11


abstract: PURPOSE: The aim of this study was to characterize treatment patterns and oncologic outcomes in @entity0 with low-volume lymph node @entity1 ( @entity2 cells [ITCs] and micrometastasis [MM]) discovered during sentinel lymph node (SLN) mapping for @entity3 . METHODS: We identified @entity3 cases treated surgically from September 2005 to April 2013 in which SLN mapping was performed. MM was defined as @entity2 within a lymph node measuring >0.2  mm but <2.0  mm, and ITCs were those measuring  <=0.2  mm. RESULTS: Overall, 844 @entity0 , with a median age of 61  years (range 30-90), met the inclusion criteria. Histology was as follows: endometrioid, 724 (85.8  %) @entity0 ; serous, 104 (12.3  %) @entity0 ; and clear cell, 16 (1.9  %) @entity0 . The median number of lymph nodes resected was six (range 0-60), and the median number of SLNs was two (range 0-15). Overall, 753 (89.2  %) @entity0 were node-negative, 23 (2.7  %) had ITCs only, 21 (2.5  %) had MM only, and 47 (5.6  %) had macrometastasis. Adjuvant chemotherapy was administered to 106 (14  %) of 753 node-negative @entity0 , 19 (83  %) of 23 @entity0 with ITCs, 17 (81  %) of 21 @entity0 with MM, and 42 (89  %) of 47 with macrometastasis. Median follow-up was 26  months (range 0-108). Three-year recurrence-free survival was as follows: node-negative @entity0 , 90  % (  1.5); ITCs only, 86  % (  9.4); MM only, 86  % (  9.7); and macrometastasis, 71  % (  7.2) [p  <  0.001]. CONCLUSIONS: @entity0 with ITCs and MM frequently received adjuvant chemotherapy and had improved oncologic outcomes in comparison to those with macrometastasis to the lymph nodes. Further prospective study is needed to determine optimal post-resection management in @entity0 with ITCs or MM alone.

title: Low-Volume Lymph Node XXXX Discovered During Sentinel Lymph Node Mapping for @entity3 .

answer: @entity1


abstract: PURPOSE: The aim of this study was to characterize treatment patterns and oncologic outcomes in @entity0 with low-volume lymph node @entity1 ( @entity2 cells [ITCs] and micrometastasis [MM]) discovered during sentinel lymph node (SLN) mapping for @entity3 . METHODS: We identified @entity3 cases treated surgically from September 2005 to April 2013 in which SLN mapping was performed. MM was defined as @entity2 within a lymph node measuring >0.2  mm but <2.0  mm, and ITCs were those measuring  <=0.2  mm. RESULTS: Overall, 844 @entity0 , with a median age of 61  years (range 30-90), met the inclusion criteria. Histology was as follows: endometrioid, 724 (85.8  %) @entity0 ; serous, 104 (12.3  %) @entity0 ; and clear cell, 16 (1.9  %) @entity0 . The median number of lymph nodes resected was six (range 0-60), and the median number of SLNs was two (range 0-15). Overall, 753 (89.2  %) @entity0 were node-negative, 23 (2.7  %) had ITCs only, 21 (2.5  %) had MM only, and 47 (5.6  %) had macrometastasis. Adjuvant chemotherapy was administered to 106 (14  %) of 753 node-negative @entity0 , 19 (83  %) of 23 @entity0 with ITCs, 17 (81  %) of 21 @entity0 with MM, and 42 (89  %) of 47 with macrometastasis. Median follow-up was 26  months (range 0-108). Three-year recurrence-free survival was as follows: node-negative @entity0 , 90  % (  1.5); ITCs only, 86  % (  9.4); MM only, 86  % (  9.7); and macrometastasis, 71  % (  7.2) [p  <  0.001]. CONCLUSIONS: @entity0 with ITCs and MM frequently received adjuvant chemotherapy and had improved oncologic outcomes in comparison to those with macrometastasis to the lymph nodes. Further prospective study is needed to determine optimal post-resection management in @entity0 with ITCs or MM alone.

title: Low-Volume Lymph Node @entity1 Discovered During Sentinel Lymph Node Mapping for XXXX .

answer: @entity3


abstract: UNASSIGNED: Background and purpose - Treatment of @entity4 ( @entity4 ) with @entity5 ( @entity5 ) consists of injection followed by finger manipulation. We used a modified method, injecting a higher dose than recommended on the label into several parts of the cord, which allows treatment of @entity3 in 1 session and may increase efficacy. We studied the occurrence of @entity1 and short-term outcome with this procedure. @entity0 and methods - We studied 164 consecutive hands with @entity4 , palpable cord, and extension deficit of >=  20   in the metacarpophalangeal (MCP) and/or proximal interphalangeal (PIP) joint (mean @entity0 age 70 years, 82% @entity0 ). A hand surgeon injected all the content of 1 @entity5 vial (approximately 0.80 mg) into multiple spots in the cord and performed finger extension under local anesthesia after 1 or 2 days. A nurse recorded @entity1 on a diagram and conducted a standard telephone follow-up within 4 weeks. A hand therapist measured joint @entity3 before injection and at a median of 23 (IQR: 7-34) days after finger extension. Results - A skin tear occurred in 66 hands (40%). The largest diameter of the tear was  <= 5 mm in 30 hands and > 10 mm in 14 hands. Hands with skin tear had greater mean pretreatment MCP extension deficit than those without tear: 59   (SD 26) as opposed to 32   (SD 23). Skin tear occurred in 21 of 24 hands with MCP @entity3 of >=  75  . All tears healed with open-wound treatment. No @entity2 occurred. Mean improvement in total (MCP + PIP) extension deficit was 55   (SD 28). Interpretation - Skin tears occurred in 40% of hands treated with collagenase injections, but only a fifth of them were larger than 1 cm. Tears were more likely in hands with severe @entity3 . All tears healed without complications. Short-term @entity3 reduction was good.

title: Collagenase treatment of XXXX using a modified injection method.

answer: @entity4


abstract: UNASSIGNED: The aim of this study was to investigate the effect of two kinds of given diets on growth, on some carcass characteristics and on the major meat nutrients of local Algerian @entity1 breed. The investigated @entity1 breed called "Hamra" is one of the most famous breeds in Algeria. Among one 106 animals, 40 @entity1 were selected according to their age, similar livestock characteristics and body weight. The samples were divided into two equal groups: control and experimental @entity1 according to their live weight; 24.63        0.47 and 24.35        0.64  kg, respectively. Both groups were fed with two varieties of concentrate diets: @entity3 diet based for the first group of control @entity1 (n   =   20) and @entity3 substituted by @entity2 (Variety Sa  da 183) for the second experimental group @entity1 (n   =   20). Both diets were supplemented with 200  g straw of @entity2 /animal/ration. The chemical analysis of diets showed an elevated crude fibre content in the commercial concentrate. However, the experimental concentrate contained higher amounts of @entity0 . After 59  days of fattening, no significant difference was found among the two studied groups on the growth performance (p   >   0.05), showing the same final body weight. In contrast, a significant difference was found (p    <=   0.001) in relation to the cost of the given diet. This could affect the price of the produced meat. At 37.85        0.78  kg live weight, 10 @entity1 fed with experimental concentrate were slaughtered. The dressing percentage was 46.65  %, with 2.49  % of carcass shrink. Furthermore, an interesting percentage of total muscle was obtained (63.73  %) with a good carcass conformation scoring 9.56. Compared to other breed @entity1 , Hamra carcass could be considered as the most valuable one economically.

title: Partial substitution of XXXX for @entity3 : effect on "Hamra" lamb growth performance, carcass and meat characteristics.

answer: @entity2


abstract: UNASSIGNED: The aim of this study was to investigate the effect of two kinds of given diets on growth, on some carcass characteristics and on the major meat nutrients of local Algerian @entity1 breed. The investigated @entity1 breed called "Hamra" is one of the most famous breeds in Algeria. Among one 106 animals, 40 @entity1 were selected according to their age, similar livestock characteristics and body weight. The samples were divided into two equal groups: control and experimental @entity1 according to their live weight; 24.63        0.47 and 24.35        0.64  kg, respectively. Both groups were fed with two varieties of concentrate diets: @entity3 diet based for the first group of control @entity1 (n   =   20) and @entity3 substituted by @entity2 (Variety Sa  da 183) for the second experimental group @entity1 (n   =   20). Both diets were supplemented with 200  g straw of @entity2 /animal/ration. The chemical analysis of diets showed an elevated crude fibre content in the commercial concentrate. However, the experimental concentrate contained higher amounts of @entity0 . After 59  days of fattening, no significant difference was found among the two studied groups on the growth performance (p   >   0.05), showing the same final body weight. In contrast, a significant difference was found (p    <=   0.001) in relation to the cost of the given diet. This could affect the price of the produced meat. At 37.85        0.78  kg live weight, 10 @entity1 fed with experimental concentrate were slaughtered. The dressing percentage was 46.65  %, with 2.49  % of carcass shrink. Furthermore, an interesting percentage of total muscle was obtained (63.73  %) with a good carcass conformation scoring 9.56. Compared to other breed @entity1 , Hamra carcass could be considered as the most valuable one economically.

title: Partial substitution of @entity2 for XXXX : effect on "Hamra" lamb growth performance, carcass and meat characteristics.

answer: @entity3


abstract: BACKGROUND: @entity5 ( @entity5 ) is a serious and rare condition that often presents a complex surgical challenge. We reviewed the evolution of surgical approaches to the management of @entity5 at a single institution. METHODS: We conducted a retrospective clinical review of all @entity0 who underwent surgical repair of @entity5 at our institution. From January 1992 to January 2014, a total of 30 @entity0 (median age 92 days; range 3 days-1.7 years) underwent surgery for @entity5 at our institution. Techniques included slide tracheoplasty (n = 16), tracheal resection (n = 10), pericardial patch tracheoplasty (n = 3), and costal cartilage tracheoplasty (n = 1). Twenty-two (73%) @entity0 had associated @entity1 , including 18 (60%) with @entity3 sling. Five (17%) @entity0 had associated @entity3 . All procedures were performed via a median sternotomy with cardiopulmonary bypass. RESULTS: Median postoperative length of stay was 25 days (range, 5-431 days). Late airway reintervention was required in seven (26%), including two (15%) @entity0 after slide tracheoplasty, two (22%) posttracheal resection, and two (100%) post pericardial patch tracheoplasty. The one @entity0 who underwent costal cartilage tracheoplasty required multiple reinterventions. Overall mortality was 13% (n = 4), two @entity2 occurred post slide tracheoplasty, one @entity2 occurred after tracheal resection, and one after pericardial patch tracheoplasty, respectively. CONCLUSION: Slide tracheoplasty is the procedure of choice for repair of @entity5 , while tracheal resection is a viable option for @entity0 with discreet, short-segment @entity4 .

title: Evolution of Surgical Approaches in the Management of XXXX : Single-Center Experience.

answer: @entity5


abstract: INTRODUCTION: @entity6 ( @entity6 ) is the interruption of the continuity of the esophagus, with or without persistent communication with the @entity4 . Recent advances in surgical techniques have made possible correction with minimally invasive surgery (MIS). OBJECTIVE: To evaluate the management of thoracoscopic technique in the treatment of @entity6 . @entity0 AND METHOD: Retrospective analysis of medical records in two centers was carried out between 2007 and 2012. Variables such as gestational age, gender, weight, type of @entity6 , @entity2 were recorded. RESULTS: Twenty @entity0 , 15 of them with type III @entity6 , 4 with type I and one unclassifiable, were part of the study. 13 @entity0 underwent ligation, cut of @entity7 and end to end @entity1 . Two underwent laparoscopic gastrostomy and @entity3 ligation. One @entity0 required conversion and underwent esophagostomy plus gastrostomy. 4 @entity0 without @entity3 required laparoscopic gastrostomy and aspiration of the proximal esophagus to be able to perform esophageal @entity1 . In the postoperative period, pleural drainage and a transanastomotic feeding tube were installed. Seven @entity0 required esophageal dilations and 4 @entity0 developed @entity5 due to reflux. Two had recurrent @entity3 , one with spontaneous resolution and another with endoscopic resolution. Three @entity0 died: two of them due to pathologies not related to surgery and one as a result of limitation of therapeutic effort after @entity3 patency. DISCUSSION: @entity6 repair with MIS is a safe and effective option with excellent exposure and visualization of anatomic landmarks and little associated morbidity.

title: [Thoracoscopic repair of @entity6 with and without XXXX ].

answer: @entity7


abstract: INTRODUCTION: @entity6 ( @entity6 ) is the interruption of the continuity of the esophagus, with or without persistent communication with the @entity4 . Recent advances in surgical techniques have made possible correction with minimally invasive surgery (MIS). OBJECTIVE: To evaluate the management of thoracoscopic technique in the treatment of @entity6 . @entity0 AND METHOD: Retrospective analysis of medical records in two centers was carried out between 2007 and 2012. Variables such as gestational age, gender, weight, type of @entity6 , @entity2 were recorded. RESULTS: Twenty @entity0 , 15 of them with type III @entity6 , 4 with type I and one unclassifiable, were part of the study. 13 @entity0 underwent ligation, cut of @entity7 and end to end @entity1 . Two underwent laparoscopic gastrostomy and @entity3 ligation. One @entity0 required conversion and underwent esophagostomy plus gastrostomy. 4 @entity0 without @entity3 required laparoscopic gastrostomy and aspiration of the proximal esophagus to be able to perform esophageal @entity1 . In the postoperative period, pleural drainage and a transanastomotic feeding tube were installed. Seven @entity0 required esophageal dilations and 4 @entity0 developed @entity5 due to reflux. Two had recurrent @entity3 , one with spontaneous resolution and another with endoscopic resolution. Three @entity0 died: two of them due to pathologies not related to surgery and one as a result of limitation of therapeutic effort after @entity3 patency. DISCUSSION: @entity6 repair with MIS is a safe and effective option with excellent exposure and visualization of anatomic landmarks and little associated morbidity.

title: [Thoracoscopic repair of XXXX with and without @entity7 ].

answer: @entity6


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: @entity0 cases numbers are increasing worldwide positioning this disease as the second cause of mortality for both sexes. Medicinal plants have been used in the fight against @entity0 as the basis for drug discovery and nowadays more than 70% of anticancer drugs have a natural origin. Mexico is regarded for its cultural and biological diversity, which is reflected in the vast traditional knowledge of herbal remedies. In this review we examined herbal remedies employed in @entity1 ( @entity1 ). AIM OF THE STUDY: The goal of this work was to gather scientific reports of plants used in Mexican traditional medicine for @entity1 treatment. MATERIALS AND METHODS: We performed a search on scientific literature databases using as keywords: " @entity4 ", " @entity3 ", " @entity2 ", studies "in vitro and in vivo", in combination with "Mexican medicinal plants" or "Mexican herbal remedies". The selection criteria of cytotoxic activity for extracts or pure compounds was based on the National @entity0 Institute of USA recommendations of effective dose 50 (ED50) of <=20 g/mL and <=4 g/mL, respectively. RESULTS: In this review we report 25 botanic families and 39 species of plants used for the treatment of @entity4 in Mexico with evidence in studies in vitro and in vivo. CONCLUSIONS: Medicinal plants are still a great source of novel chemical structures with antineoplastic potential as it is proven in this work. The selection criteria and activity was narrowed for methodological purposes, nevertheless, drug discovery of natural origin continues to be a highly attractive R_D strategy.

title: Medicinal plants used in Mexican traditional medicine for the treatment of XXXX .

answer: @entity1


abstract: INTRODUCTION: Primary @entity1 of lung (PSGTTL) are rare intra-thoracic malignant @entity1 . Their description in literature is largely limited to a few case series/case reports. We herewith present our surgical experience of and review its clinical presentation, management options and survival outcomes. METHODS: This retrospective analysis of prospectively maintained computerized data-base of @entity0 was conducted in a tertiary teaching oncology centre in North India. The case records of all the @entity0 who underwent surgery for PSGTTL were reviewed. Details concerning the clinical presentation, preoperative therapy, operative procedure, histopathological examination, @entity2 and outcome were retrieved from the case records. RESULTS: There were seven @entity0 who underwent surgery for PSGTTL during the period from January 2012 to December 2014. Hemoptysis (n = 6, 85.7%) and dyspnoea (n = 6, 85.7%) were common presenting clinical features. Fiber-optic bronchoscopy revealed endobronchial growth in all @entity0 - five @entity0 had growth in left main bronchus while one each had growth in right main bronchus and right intermediate bronchus. Biopsy confirmed adenoid cystic carcinoma in 4 (57.1%) and muco-epidermoid carcinoma in 3 (42.9%) @entity0 . All but one had R'0' resection - pneumonectomy in five and bilobectomy in one @entity0 ; one @entity0 was found to be unresectable in view of dense adhesions between lung and heart. Median pathological tumor size was 3.5 cm; none of the @entity0 was found to have metastatic spread to lymph nodes. Overall, six @entity0 are alive after a median follow up of 5 months (range 1-30). CONCLUSION: Radical surgery to achieve R'0' resection is the main stay of treatment of PSGTTL to achieve prolonged survival.

title: Surgical experience of primary XXXX of lung: A case series.

answer: @entity1


abstract: @entity5 are a common form of @entity3 of the lymphatic vessels, mainly in the head and neck region. Most cases are progressive evolution and require a multidisciplinary approach. Currently, the first therapeutic option is sclerotherapy, leaving surgery for the treatment of remaining lesions. OBJECTIVE: To present a case of @entity6 (LM) treated with sclerotherapy, surgery and orthodontics in a 15-year follow up. CASE REPORT: A one-year-old female @entity0 who consulted health professionals due to a progressive volume increase of the soft parts of her right cheek. The imaging study confirmed the diagnosis of @entity1 . It was managed with @entity2 sclerotherapy and @entity4 . At 2 years of age, the @entity0 response was considered adequate; an intralesional submandibular surgical excision was then performed, with partial resection of the lesion. The biopsy confirmed the diagnosis of microcystic LM. Six months after, a re-resection was planned using the same approach and removing the remaining lesion, with favorable development until the age of 9 years when the @entity0 required surgery and orthodontic management due to intraoral recurrence. No major developments until the age of 13 when a new orthodontic surgery and handling are planned to perform right oral commissure suspension. CONCLUSION: LM management by sclerotherapy, surgery, and orthodontics has shown the advantages of a multidisciplinary long-term treatment in this case.

title: [Mixed XXXX : Case report].

answer: @entity6


abstract: BACKGROUND: The objective of this meta-analysis was to evaluate the risk of @entity1 in @entity0 who received renin-angiotensin system (RAS) inhibitors. METHODS: A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception through November, 2014. Studies that reported relative risks, odd ratios or hazard ratios comparing the @entity1 risk in @entity0 who received angiotensin-converting-enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) vs. those who did not were included. We performed the prespecified sensitivity analysis including only only studies with confounder adjusted analysis. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. RESULTS: Seven studies (2 cohort and 5 cross-sectional studies) with 29   061 @entity0 were included in the analysis to assess the risk of @entity1 and the RAS inhibitors use. The pooled RR of @entity1 in @entity0 receiving ACEIs was 1.56 (95% CI, 1.40-1.73, I(2)   =   17%). When meta-analysis was limited only to studies with confounder adjusted analysis, the pooled RR of @entity1 in @entity0 using ACEIs was 1.57 (95% CI, 1.43-1.73, I(2)   =   0%) The pooled RR of @entity1 in @entity0 receiving ARBs was 1.60 (95% CI, 1.27-2.00, I(2)   =   39%). The meta-analysis of studies with confounder adjusted analysis demonstrated the pooled RR of @entity1 in @entity0 using ARBs of 1.59 (95% CI, 1.38-1.83, I(2)   =   0%). CONCLUSIONS: Our meta-analysis demonstrates an association between @entity1 and the use of RAS inhibitors. Hematological parameters should be monitored in @entity0 treated with RAS inhibitors.

title: XXXX : a systematic review and meta-analysis.

answer: @entity1


abstract: OBJECTIVE The Dynesys, a @entity7 ( @entity7 ) system, was introduced to overcome the drawbacks of fusion procedures. Nevertheless, the theoretical advantages of @entity7 over fusion have not been clearly confirmed. The aim of this study was to compare clinical and radiological outcomes of @entity0 who underwent @entity7 using the Dynesys system with those who underwent @entity8 ( @entity8 ). METHODS The authors searched PubMed, Embase, Web of Science, and the Cochrane Database. Studies that reported outcomes of @entity0 who underwent @entity7 or @entity8 for the treatment of @entity2 were included. The primary efficacy end points were perioperative outcomes. The secondary efficacy end points were changes in the @entity6 visual analog scale (VAS) scores and in range of motion (ROM) at the treated and adjacent segments. A meta-analysis was performed to calculate @entity4 ( @entity4 ), 95% confidence intervals, Q statistics, and I(2) values. Forest plots were constructed for each analysis group. RESULTS Of the 274 retrieved articles, 7 (which involved 506 @entity0 [Dynesys, 250; @entity8 , 256]) met the inclusion criteria. The Dynesys group showed a competitive advantage in mean surgery duration (20.73 minutes, 95% CI 8.76-32.70 minutes), @entity3 (81.87 ml, 95% CI 45.11-118.63 ml), and length of hospital stay (1.32 days, 95% CI 0.23-2.41 days). Both the Dynesys and @entity8 groups experienced improved ODI and VAS scores after 2 years of follow-up. Regarding the ODI and VAS scores, no statistically significant difference was noted according to surgical procedure (ODI: WMD 0.12, 95% CI -3.48 to 3.72; back @entity1 VAS score: WMD -0.15; 95% CI -0.56 to 0.26; leg @entity1 VAS score: WMD -0.07; 95% CI -0.47 to 0.32). The mean ROM at the adjacent segment increased in both groups, and there was no substantial difference between them (WMD 1.13; 95% CI -0.33 to 2.59). Although the United States is the biggest market for Dynesys, no eligible study from the United States was found, and 4 of 8 enrolled studies were performed in China. The results must be interpreted with caution because of publication bias. During Dynesys implantation, surgeons have to decide the length of the spacer and cord pretension. These values are debatable and can vary according to the surgeon's experience and the @entity0 's condition. Differences between the surgical procedures were not considered in this study. CONCLUSIONS Fusion still remains the method of choice for @entity5 and gross instability. However, @entity2 with or without Grade I spondylolisthesis, particularly in @entity0 who require a quicker recovery, will likely constitute the main indication for @entity7 using the Dynesys system.

title: Dynamic stabilization using the Dynesys system versus @entity8 for the treatment of XXXX : a clinical and radiological outcomes-based meta-analysis.

answer: @entity2


abstract: OBJECTIVE The Dynesys, a @entity7 ( @entity7 ) system, was introduced to overcome the drawbacks of fusion procedures. Nevertheless, the theoretical advantages of @entity7 over fusion have not been clearly confirmed. The aim of this study was to compare clinical and radiological outcomes of @entity0 who underwent @entity7 using the Dynesys system with those who underwent @entity8 ( @entity8 ). METHODS The authors searched PubMed, Embase, Web of Science, and the Cochrane Database. Studies that reported outcomes of @entity0 who underwent @entity7 or @entity8 for the treatment of @entity2 were included. The primary efficacy end points were perioperative outcomes. The secondary efficacy end points were changes in the @entity6 visual analog scale (VAS) scores and in range of motion (ROM) at the treated and adjacent segments. A meta-analysis was performed to calculate @entity4 ( @entity4 ), 95% confidence intervals, Q statistics, and I(2) values. Forest plots were constructed for each analysis group. RESULTS Of the 274 retrieved articles, 7 (which involved 506 @entity0 [Dynesys, 250; @entity8 , 256]) met the inclusion criteria. The Dynesys group showed a competitive advantage in mean surgery duration (20.73 minutes, 95% CI 8.76-32.70 minutes), @entity3 (81.87 ml, 95% CI 45.11-118.63 ml), and length of hospital stay (1.32 days, 95% CI 0.23-2.41 days). Both the Dynesys and @entity8 groups experienced improved ODI and VAS scores after 2 years of follow-up. Regarding the ODI and VAS scores, no statistically significant difference was noted according to surgical procedure (ODI: WMD 0.12, 95% CI -3.48 to 3.72; back @entity1 VAS score: WMD -0.15; 95% CI -0.56 to 0.26; leg @entity1 VAS score: WMD -0.07; 95% CI -0.47 to 0.32). The mean ROM at the adjacent segment increased in both groups, and there was no substantial difference between them (WMD 1.13; 95% CI -0.33 to 2.59). Although the United States is the biggest market for Dynesys, no eligible study from the United States was found, and 4 of 8 enrolled studies were performed in China. The results must be interpreted with caution because of publication bias. During Dynesys implantation, surgeons have to decide the length of the spacer and cord pretension. These values are debatable and can vary according to the surgeon's experience and the @entity0 's condition. Differences between the surgical procedures were not considered in this study. CONCLUSIONS Fusion still remains the method of choice for @entity5 and gross instability. However, @entity2 with or without Grade I spondylolisthesis, particularly in @entity0 who require a quicker recovery, will likely constitute the main indication for @entity7 using the Dynesys system.

title: Dynamic stabilization using the Dynesys system versus XXXX for the treatment of @entity2 : a clinical and radiological outcomes-based meta-analysis.

answer: @entity8


abstract: BACKGROUND: Type 2 @entity1 is a major challenge for Canadian public health authorities, and regular physical activity is a key factor in the management of this disease. Given that fewer than half of @entity0 with @entity2 2 @entity1 in Canada are sufficiently active to meet the recommendations, effective programs targeting the adoption of regular physical activity (PA) are in demand for this population. Many researchers argue that Web-based, tailored interventions targeting PA are a promising and effective avenue for sedentary populations like Canadians with @entity2 2 @entity1 , but few have described the detailed development of this kind of intervention. OBJECTIVE: This paper aims to describe the systematic development of the Web-based, tailored intervention, Diab  te en Forme, promoting regular aerobic PA among adult Canadian francophones with @entity2 2 @entity1 . This paper can be used as a reference for health professionals interested in developing similar interventions. We also explored the integration of theoretical components derived from the I-Change Model, Self-Determination Theory, and Motivational Interviewing, which is a potential path for enhancing the effectiveness of tailored interventions on PA adoption and maintenance. METHODS: The intervention development was based on the program-planning model for tailored interventions of Kreuter et al. An additional step was added to the model to evaluate the intervention's usability prior to the implementation phase. An 8-week intervention was developed. The key components of the intervention include a self-monitoring tool for PA behavior, a weekly action planning tool, and eight tailored motivational sessions based on attitude, self-efficacy, intention, @entity2 of motivation, PA behavior, and other constructs and techniques. Usability evaluation, a step added to the program-planning model, helped to make several improvements to the intervention prior to the implementation phase. RESULTS: The intervention development cost was about CDN  59,700 and took approximately 54 full-time weeks. The intervention officially started on September 29, 2014. Out of 2300 potential @entity0 targeted for the tailored intervention, approximately 530 @entity0 visited the website, 170 @entity0 completed the registration process, and 83 corresponded to the selection criteria and were enrolled in the intervention. CONCLUSIONS: Usability evaluation is an essential step in the development of a Web-based tailored intervention in order to make pre-implementation improvements. The effectiveness and relevance of the theoretical framework used for the intervention will be analyzed following the process and impact evaluation. Implications for future research are discussed.

title: Development of a fully automated, web-based, tailored intervention promoting regular physical activity among insufficiently active adults with XXXX 2 @entity1 : integrating the I-change model, self-determination theory, and motivational interviewing components.

answer: @entity2


abstract: BACKGROUND: Type 2 @entity1 is a major challenge for Canadian public health authorities, and regular physical activity is a key factor in the management of this disease. Given that fewer than half of @entity0 with @entity2 2 @entity1 in Canada are sufficiently active to meet the recommendations, effective programs targeting the adoption of regular physical activity (PA) are in demand for this population. Many researchers argue that Web-based, tailored interventions targeting PA are a promising and effective avenue for sedentary populations like Canadians with @entity2 2 @entity1 , but few have described the detailed development of this kind of intervention. OBJECTIVE: This paper aims to describe the systematic development of the Web-based, tailored intervention, Diab  te en Forme, promoting regular aerobic PA among adult Canadian francophones with @entity2 2 @entity1 . This paper can be used as a reference for health professionals interested in developing similar interventions. We also explored the integration of theoretical components derived from the I-Change Model, Self-Determination Theory, and Motivational Interviewing, which is a potential path for enhancing the effectiveness of tailored interventions on PA adoption and maintenance. METHODS: The intervention development was based on the program-planning model for tailored interventions of Kreuter et al. An additional step was added to the model to evaluate the intervention's usability prior to the implementation phase. An 8-week intervention was developed. The key components of the intervention include a self-monitoring tool for PA behavior, a weekly action planning tool, and eight tailored motivational sessions based on attitude, self-efficacy, intention, @entity2 of motivation, PA behavior, and other constructs and techniques. Usability evaluation, a step added to the program-planning model, helped to make several improvements to the intervention prior to the implementation phase. RESULTS: The intervention development cost was about CDN  59,700 and took approximately 54 full-time weeks. The intervention officially started on September 29, 2014. Out of 2300 potential @entity0 targeted for the tailored intervention, approximately 530 @entity0 visited the website, 170 @entity0 completed the registration process, and 83 corresponded to the selection criteria and were enrolled in the intervention. CONCLUSIONS: Usability evaluation is an essential step in the development of a Web-based tailored intervention in order to make pre-implementation improvements. The effectiveness and relevance of the theoretical framework used for the intervention will be analyzed following the process and impact evaluation. Implications for future research are discussed.

title: Development of a fully automated, web-based, tailored intervention promoting regular physical activity among insufficiently active adults with @entity2 2 XXXX : integrating the I-change model, self-determination theory, and motivational interviewing components.

answer: @entity1


abstract: OBJECTIVE: To examine the effect of exercise therapy on the walking ability of individuals with @entity1 . DATA SOURCES: @entity2 ( @entity2 ) were identified by searching through PubMed, Cochrane Central Register of Controlled Trials, Physiotherapy Evidence Database, and Cumulative Index to Nursing and Allied Health Literature. All literature published to October 2014 were included in the search. REVIEW METHODS: Data were collected from @entity2 that compared the effects of exercise therapy on walking ability with the effects of no intervention or psychoeducational intervention in @entity0 with @entity1 . The outcome data on the total distance walked (6-minute walk test); the amount of time spent walking (the time to walk arbitrary distances); and gait velocity were obtained and analysed. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated. RESULTS: Twenty-eight @entity2 were identified. Meta-analysis provided very-low-quality evidence that exercise therapy increased the total distance walked in the 6-minute walk test, in comparison with the effects of the control interventions ( @entity3 = 0.44, 95% CI 0.27 to 0.60). Meta-analysis also provided low- or moderate-quality evidence that the amount of time spent walking and gait velocity were improved more by exercise therapy than by the control interventions (the amount of time spent walking: @entity3 = -0.50, 95% CI -0.70 to -0.30; gait velocity: @entity3 = 1.78, 95% CI 0.98 to 2.58). CONCLUSION: In individuals with @entity1 , exercise therapy can improve the amount of time spent walking, gait velocity, and maybe the total distance walked.

title: Effects of exercise therapy on walking ability in individuals with XXXX : A systematic review and meta-analysis of randomised controlled trials.

answer: @entity1


abstract: UNASSIGNED: Reduced @entity2 ( @entity2 ) levels and higher soluble fms-like @entity1 kinase (sFlt-1) levels in mothers during pregnancy may have persistent effects on vascular structures in their offspring. We examined whether angiogenic factors during pregnancy also affect childhood retinal microvasculature in a population-based prospective cohort study among 3505 mothers and their @entity0 . We measured maternal @entity2 and sFlt-1 in the first and second trimester of pregnancy. At the age of 6, we measured childhood retinal arteriolar and venular calibers from digitized retinal photographs. We performed multiple linear regression models, taking maternal and childhood sociodemographic and lifestyle-related characteristics, birth characteristics, and childhood current body mass index and blood pressure into account. We observed that first trimester maternal @entity2 and sFlt-1 levels were not associated with childhood retinal arteriolar caliber. Lower second trimester maternal @entity2 levels, but not sFlt-1 levels, were associated with narrower childhood retinal arteriolar caliber (difference: -0.09 SD score [95% confidence interval, -0.16 to 0.01], per SD score decrease in @entity2 ). This association was not explained by maternal and childhood sociodemographic and lifestyle-related characteristics, birth characteristics, or childhood current body mass index and blood pressure. Maternal @entity2 and sFlt-1 levels in the first or second trimester were not associated with childhood retinal venular caliber. Our results suggest that lower maternal second trimester @entity2 levels affect the microvascular development in the offspring, leading to narrower retinal arteriolar caliber in childhood. Further studies are needed to confirm these findings and to explore the underlying mechanisms and long-term cardiovascular consequences.

title: Influence of Maternal Angiogenic Factors During Pregnancy on Microvascular Structure in School-Age XXXX .

answer: @entity0


abstract: A large-scale trial of methods of early detection of @entity0 has been started in Great Britain. This non-randomized trial aims to compare @entity0 mortality over several years among @entity1 aged 45-64 years who have been offered various services for early detection of @entity0 . A quantitative assessment of benefits (lives saved) and costs (unnecessary surgery, radiation hazard, and use of health service resources) will be made. A total population of over 250,000 @entity1 living in eight districts is being studied in the trial. In two districts the @entity1 are invited for annual screening by clinical examination and mammography; in two other districts they are invited to teaching sessions to learn breast self-examination. The remaining four districts, with a population of 120,000 @entity1 , serve as a comparison and have no extra services beyond conventional diagnostic facilities. A register of all breast histology among these @entity1 has been set up, and, for those who have @entity0 , details of diagnosis, treatment and annual follow-up are recorded. All changes to the population are noted, and the cause of all @entity3 recorded. Factors influencing acceptance of early detection programmes, and the sensitivity and specificity of different screening methods are being studied. Mortality rates from @entity0 in the three types of population (screening, self-examination and comparison groups) will be the main index of effectiveness, but other questions relative to evaluation of screening, such as lead-time natural history of pre-invasive @entity2 , and identification of high-risk @entity1 , will also be assessed.

title: [Evaluation of early detection of XXXX in Great Britain (author's transl)].

answer: @entity0


abstract: OBJECTIVE: We report our experience in providing palliative radiotherapy (RT) to @entity0 with @entity2 ( @entity2 ). Our hypofractionated regimen, "0-7-21", treats @entity0 with 24   Gy in three fractions. METHODS: @entity0 , disease and response data were retrieved for candidates of 0-7-21 from 2005 to 2012. Primary end points included symptom and @entity1 size responses to RT based on response evaluation criteria in solid @entity1 (RECIST) guidelines. Secondary end points included progression-free survival (PFS) within the irradiated field, @entity4 ( @entity4 ) and symptomatic PFS (SPFS), calculated using Kaplan-Meier method and adverse events. Cox proportional hazards regression and logistic regression were used to investigate for prognostic factors. RESULTS: A total of 110 @entity0 were included. Among the @entity0 , 40% and 31% had complete response for symptoms and @entity1 size, respectively; 42% and 50% had partial response for symptoms and @entity1 size, respectively; and 15% had stability of symptoms and @entity1 size. Median 6-month @entity4 was 51%, and PFS within the irradiated field was 39%. Planning target volume was predictive of @entity4 (p   <   0.001), PFS (p   <   0.001) and SPFS (p   <   0.005), while higher TNM stage was associated with poorer @entity1 response (p   =   0.02). CONCLUSION: 0-7-21 is an effective and well-tolerated palliative RT regimen for @entity0 with HNC. There was excellent symptom and local control with acceptable @entity3 profile in these @entity0 . ADVANCES IN KNOWLEDGE: This is the first study to describe the outcomes of 0-7-21 in treating advanced @entity2 . The positive results suggest that 0-7-21 provides excellent palliation with minimal @entity3 , with significantly less on-treatment time than current published palliative RT regimen.

title: 0-7-21 hypofractionated palliative radiotherapy: an effective treatment for advanced XXXX .

answer: @entity2


abstract: BACKGROUND: Recombinant bone morphogenetic protein two (rhBMP2) has been utilised for a variety of clinical applications in orthopaedic surgery and dental procedures. Despite its widespread use, concerns have been raised regarding its short half-life and transient bioactivity in vivo. Recent investigation aimed at developing rhBMP2 synthesized from a shorter polypeptide chain (108 @entity3 ) has been undertaken. METHODS: The osteopromotive properties of @entity2 were investigated on cell behaviour. Five concentrations of rhBMP2_108 including 10, 50, 100, 200 and 500  ng/ml were compared to a commercially available rhBMP2 (100  ng/ml). Each of the working concentrations of rhBMP2_108 were investigated on MC3T3-E1 osteoblasts for their ability to induce osteoblast recruitment, proliferation and differentiation as assessed by @entity1 ( @entity1 ) staining, @entity0 staining, and real-time PCR for genes encoding @entity1 , @entity5 ( @entity5 ), collagen-1 (COL-1) and @entity4 . RESULTS: The results demonstrate that all concentrations of rhBMP2_108 significantly improved cell recruitment and proliferation of osteoblasts at 5  days post seeding. Furthermore, rhBMP2_108 had the most pronounced effects on osteoblast differentiation. It was found that rhBMP2_108 had over a four fold significant increase in @entity1 activity at seven and 14  days post-seeding and the concentrations ranging from 50 to 200  ng/ml demonstrated the most pronounced effects. Analysis of real-time PCR for genes encoding @entity1 , @entity5 , COL-1 and @entity4 further confirmed dose-dependant increases at 14  days post-seeding. Furthermore, @entity0 staining demonstrated a concentration dependant increase in staining at 14  days. CONCLUSION: The results from the present study demonstrate that this shorter polypeptide chain of rhBMP2_108 is equally as bioactive as commercially available rhBMP2 for the recruitment of progenitor cells by facilitating their differentiation towards the osteoblast lineage. Future in vivo study are necessary to investigate its bioactivity.

title: Characterization of a shorter recombinant polypeptide chain of XXXX on osteoblast behaviour.

answer: @entity2


abstract: Conventional @entity1 manure treatment is performed by anaerobic digestion, but @entity0 is not treated. Microbial Fuel Cells (MFCs) allow organic matter and @entity0 removal with concomitant electricity production. MFC microbiomes treating industrial wastewaters as @entity1 manure have not been characterized. In this study, a multidisciplinary approach allowed microbiome relation with nutrient removal capacity and electricity production. Two different MFC configurations ( @entity3 ) were used to treat @entity1 manure. In C-1, the nitrification and denitrification processes took place in different compartments, while in @entity3 , simultaneous nitrification-denitrification occurred in the cathode. Clostridium disporicum and @entity2 were identified in the anode compartments of both systems. C. disporicum was related to the degradation of complex organic matter compounds and @entity2 to electricity production. Different nitrifying bacteria populations were identified in both systems because of the different operational conditions. The highest microbial diversity was detected in cathode compartments of both configurations, including members of Bacteroidetes, Chloroflexiaceae and Proteobacteria. These communities allowed similar removal rates of organic matter (2.02-2.09kg CODm(-3)d(-1)) and @entity0 (0.11-0.16kgNm(-3)d(-1)) in both systems. However, they differed in the generation of electric energy (20 and 2mWm(-3) in C-1 and @entity3 , respectively).

title: Microbiome characterization of MFCs used for the treatment of XXXX manure.

answer: @entity1


abstract: BACKGROUND: We sought to determine the incidence of @entity1 due to surgical compromise of the coronary ostia in @entity2 . The mechanism of coronary ostium blockage was also investigated. METHODS: A retrospective review was conducted of prospectively collected clinical data and autopsy findings in 322 @entity0 who died in hospital after @entity2 with or without concomitant procedures in a single institution from January 1998 to March 2013. RESULTS: Over the 15-year period, more than 17 surgeons performed 7507 aortic valve replacements with or without other procedures. The mean age of the @entity0 was 70.8        11.78 years and 63% were male. Bioprosthetic valves were used in 75%, mechanical valves in 24.7%, and homografts in only 0.3%. Early mortality for all @entity0 (combined, emergency, and redo procedures) was 4.29% (mean logistic EuroSCORE 10.7). There were 322 deaths after procedures involving the aortic valve. Autopsy examinations were carried out in all @entity0 and showed that 3.4% (n   =   11) of deaths were at least partly attributed to encroachment on one or both coronary ostia. Causes of ostial compromise included the valve sutures, the valve sewing ring, and the aortotomy suture line. CONCLUSIONS: Coronary ostial compromise in @entity2 is a very rare but real problem occurring in at least 0.15% of aortic valve replacements and contributing to or directly causing one in every 29 @entity2 deaths. Surgeons should have a high level of awareness of the risk of this rare but fatal and avoidable complication.

title: Coronary ostial compromise in XXXX : An avoidable complication.

answer: @entity2


abstract: OBJECTIVE: Surgical detethering is a traditional treatment for symptomatic @entity6 . However, such complications as @entity11 and @entity1 are common. Homogeneous spinal-shortening axial decompression (HSAD) is a modified procedure of monosegmental @entity10 and it is a novel surgical alternative of reducing neural tension indirectly. The objective was to evaluate the surgical outcomes of HSAD for @entity6 . METHODS: The surgical outcomes were examined for 15 consecutive @entity0 with @entity6 undergoing HSAD from April 2010 to July 2014. Improvements of neurological symptoms including @entity9 , @entity7 and/or gait abnormalities, @entity8 , @entity5 and @entity4 were evaluated. RESULTS: Their average follow-up period was 21.5 months. The length of spinal column shortening was 17.2    2.9 mm. @entity9 (n = 9) was the most common residual deficit. All 9 @entity0 with @entity7 reported improvements, although deficits persisted at the last follow-up. All @entity0 with @entity2 improved and 4 (50.0%) noted complete resolution of preoperative @entity7 . All @entity0 reported immediate low-back or lower-extremity @entity3 relief after HSAD. One @entity0 reported improved sexual functioning and regained complete erectile capabilities. Two @entity0 (11%) experienced less satisfactory symptomatic or functional benefit from HSAD. However, the main objective of surgery was to prevent further worsening of neurological status. Complete bone union at osteotomy site was noted in all cases at the last follow-up. CONCLUSION: As a novel surgical option for @entity6 , HSAD may avoid such complications as @entity11 or @entity1 commonly encountered during traditional detethering surgery. All @entity0 gain satisfactory functional outcomes without complications compared to their preoperative symptoms.

title: [Homogeneous spinal-shortening axial decompression procedure for XXXX ].

answer: @entity6


abstract: OBJECTIVE: To investigate incidence and clinical features of multiple organ involvement in Chinese @entity0 with @entity6 . METHODS: We collected 151 @entity0 of 31 families with @entity6 , all of whom were confirmed by classic pathology, @entity7 A activity or @entity8 mutation from the year of 2011 to 2014 in Department of Neurology, Peking University First Hospital. The clinical data included incidence and onset of @entity2 , @entity1 , @entity5 , @entity4 and @entity3 . We calculate the incidence of these symptoms and analyze their gender difference using chi-square with SPSS 17.0 software. RESULTS: Among 31 families with @entity6 , 151 @entity0 (82 males and 69 females) were affected, including 91 @entity0 (60.26%) with @entity2 , 62 @entity0 (41.06%) with @entity1 , 33 @entity0 (21.85%) with @entity5 , 33 @entity0 (21.85%) with @entity4 , and 21 @entity0 (13.91%) with @entity3 . The peak incidence of @entity2 was from 10 to 20 years old, followed by @entity1 from 30 to 40 years old, @entity5 and @entity3 from 40 to 50 years old. There is no peak period for @entity4 . Except for males with higher incidence of @entity1 than females (P < 0.05), there were no gender difference in the incidence of other organ involvement. CONCLUSION: The incidence and onset of multiple organ dysfunction in Chinese @entity0 with @entity6 displayed special regularity. Gender difference appeared only in @entity1 .

title: [Investigation of multiple organ involvement in XXXX ].

answer: @entity6


abstract: UNASSIGNED: The GHEP-ISFG Working Group has recognized the importance of assisting DNA laboratories to gain expertise in handling DVI or missing @entity0 identification ( @entity1 ) projects which involve the need for large-scale genetic profile comparisons. Eleven laboratories participated in a DNA matching exercise to identify victims from a hypothetical conflict with 193 missing @entity0 . The post mortem database was comprised of 87 skeletal remain profiles from a secondary mass grave displaying a minimal number of 58 individuals with evidence of commingling. The reference database was represented by 286 family reference profiles with diverse pedigrees. The goal of the exercise was to correctly discover re-associations and family matches. The results of direct matching for commingled remains re-associations were correct and fully concordant among all laboratories. However, the kinship analysis for missing @entity0 identifications showed variable results among the @entity0 . There was a group of laboratories with correct, concordant results but nearly half of the others showed discrepant results exhibiting likelihood ratio differences of several degrees of magnitude in some cases. Three main errors were detected: (a) some laboratories did not use the complete reference family genetic data to report the match with the remains, (b) the identity and/or non-identity hypotheses were sometimes wrongly expressed in the likelihood ratio calculations, and (c) many laboratories did not properly evaluate the prior odds for the event. The results suggest that large-scale profile comparisons for @entity1 is a challenge for forensic genetics laboratories and the statistical treatment of DNA matching and the Bayesian framework should be better standardized among laboratories.

title: GHEP-ISFG collaborative simulated exercise for XXXX : Lessons learned about large-scale profile database comparisons.

answer: @entity1


abstract: PURPOSE: To describe the retinal manifestations in @entity5 ( @entity5 ) related to an @entity1 by the @entity7 ). METHODS: Retrospective case series of @entity0 with @entity5 with retinal findings. RESULTS: A total of 175 @entity0 were diagnosed with @entity5 in Martinique between 1983 and 2013. Three of them showed intraocular findings related to @entity5 . They were bilateral @entity6 associated with intermediate @entity4 . In two cases, the @entity5 diagnosis was known. In the third, @entity2 angiography was remarkable for @entity6 although fundus examination was unremarkable. The @entity5 cells were found in the blood of this @entity0 . Despite chemotherapy, infiltrates progressed from the retinal periphery to the posterior pole in two @entity0 , thus reducing visual acuity to light perception. They were associated with @entity3 . CONCLUSION: Retinal involvement in @entity5 is very rare. It can occur at any point during the natural course of the disease. @entity7 carriers should benefit from a regular ophthalmic examination, and a @entity2 angiography must be performed in all @entity0 with @entity7 with vitreous cells. The presence of @entity6 must raise suspicion for @entity5 in a @entity0 with @entity7 .

title: RETINAL MANIFESTATIONS IN ADULT T-CELL LEUKEMIA/LYMPHOMA RELATED TO INFECTION BY THE XXXX .

answer: @entity7


abstract: The feasibility of laparoscopic surgery for peritoneal @entity1 is still controversial. A 42-year-old male presenting with bloody stool underwent small intestinal fiberscopic examination. The biopsied specimens pathologically demonstrated @entity3 of the upper jejunum. Laparoscopy revealed a 10-mm nodule in the omentum. Laparoscopic partial jejunal resection with regional lymph node dissection was performed with combined resection of the nodule without conversion. No other @entity2 was detected. The resected specimen contained an irregular @entity2 measuring 52 x 33 mm. Microscopic examination revealed that the mass and peritoneal nodule comprised moderately differentiated @entity3 . After surgery, the @entity0 was treated with @entity7 /bolus and infusional 5- @entity5 / @entity4 for 6 months. Eleven months after surgery, a solitary peritoneal recurrence developed near the camera port site. Six months later, positron emission tomography, computer tomography, and exploratory laparotomy revealed multiple peritoneal recurrences. The @entity0 was then treated with @entity7 /bolus and infusional @entity5 / @entity6 . Three months and 6 months later partial remission and complete response, respectively were sequentially induced. The @entity0 is alive 3 years and 9 months after initial surgery without any @entity2 recurrence. To our knowledge, this is the first report to demonstrate laparoscopic surgery combined with chemotherapy regimens, which induced a successful complete response.

title: Impact of laparoscopic surgery on survival of @entity0 with XXXX and peritoneal @entity1 .

answer: @entity3


abstract: The feasibility of laparoscopic surgery for peritoneal @entity1 is still controversial. A 42-year-old male presenting with bloody stool underwent small intestinal fiberscopic examination. The biopsied specimens pathologically demonstrated @entity3 of the upper jejunum. Laparoscopy revealed a 10-mm nodule in the omentum. Laparoscopic partial jejunal resection with regional lymph node dissection was performed with combined resection of the nodule without conversion. No other @entity2 was detected. The resected specimen contained an irregular @entity2 measuring 52 x 33 mm. Microscopic examination revealed that the mass and peritoneal nodule comprised moderately differentiated @entity3 . After surgery, the @entity0 was treated with @entity7 /bolus and infusional 5- @entity5 / @entity4 for 6 months. Eleven months after surgery, a solitary peritoneal recurrence developed near the camera port site. Six months later, positron emission tomography, computer tomography, and exploratory laparotomy revealed multiple peritoneal recurrences. The @entity0 was then treated with @entity7 /bolus and infusional @entity5 / @entity6 . Three months and 6 months later partial remission and complete response, respectively were sequentially induced. The @entity0 is alive 3 years and 9 months after initial surgery without any @entity2 recurrence. To our knowledge, this is the first report to demonstrate laparoscopic surgery combined with chemotherapy regimens, which induced a successful complete response.

title: Impact of laparoscopic surgery on survival of @entity0 with @entity3 and peritoneal XXXX .

answer: @entity1


abstract: The feasibility of laparoscopic surgery for peritoneal @entity1 is still controversial. A 42-year-old male presenting with bloody stool underwent small intestinal fiberscopic examination. The biopsied specimens pathologically demonstrated @entity3 of the upper jejunum. Laparoscopy revealed a 10-mm nodule in the omentum. Laparoscopic partial jejunal resection with regional lymph node dissection was performed with combined resection of the nodule without conversion. No other @entity2 was detected. The resected specimen contained an irregular @entity2 measuring 52 x 33 mm. Microscopic examination revealed that the mass and peritoneal nodule comprised moderately differentiated @entity3 . After surgery, the @entity0 was treated with @entity7 /bolus and infusional 5- @entity5 / @entity4 for 6 months. Eleven months after surgery, a solitary peritoneal recurrence developed near the camera port site. Six months later, positron emission tomography, computer tomography, and exploratory laparotomy revealed multiple peritoneal recurrences. The @entity0 was then treated with @entity7 /bolus and infusional @entity5 / @entity6 . Three months and 6 months later partial remission and complete response, respectively were sequentially induced. The @entity0 is alive 3 years and 9 months after initial surgery without any @entity2 recurrence. To our knowledge, this is the first report to demonstrate laparoscopic surgery combined with chemotherapy regimens, which induced a successful complete response.

title: Impact of laparoscopic surgery on survival of XXXX with @entity3 and peritoneal @entity1 .

answer: @entity0


abstract: BACKGROUND/AIMS: Age, sex, gene and life style are modulating risks for @entity3 . Although @entity1 intake may impact on @entity4 , clear association has not been established yet. We aimed to investigate effects of @entity1 consumption on the characteristics of @entity4 . METHODS: @entity0 who underwent colonoscopic polypectomy of @entity4 in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The @entity1 drinking @entity0 were subdivided into normal or abnormal laboratory group, and @entity5 group. RESULTS: 212 @entity0 with @entity4 were analyzed; advanced @entity2 and multiple @entity2 were found in 68 (32.0%) and 79 (37.2%) @entity0 . When compared to the nondrinker group (120/212 @entity0 ), the @entity1 drinker group (92/212 @entity0 ) represented significantly high odds ratios (ORs) for advanced @entity2 (OR, 2.697; P=0.002), and multiple @entity2 (OR, 1.929; P=0.039). Among @entity1 drinker (92 @entity0 ), the ORs of advanced @entity2 were 6.407 (P=0.003) in @entity5 group (17 @entity0 ), 3.711 (P=0.002) in the @entity1 drinker with abnormal lab (24 @entity0 ), and 2.184 (P=0.034), in the @entity1 drinker with normal lab (51 @entity0 ) compared to nondrinker group. CONCLUSIONS: This study showed that @entity1 drinking may influence on the development of advanced @entity4 and multiplicity. Especially in the group with @entity5 and with abnormal lab presented significantly higher ORs of advanced @entity2 .

title: @entity1 drinking increased the risk of advanced XXXX .

answer: @entity4


abstract: BACKGROUND/AIMS: Age, sex, gene and life style are modulating risks for @entity3 . Although @entity1 intake may impact on @entity4 , clear association has not been established yet. We aimed to investigate effects of @entity1 consumption on the characteristics of @entity4 . METHODS: @entity0 who underwent colonoscopic polypectomy of @entity4 in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The @entity1 drinking @entity0 were subdivided into normal or abnormal laboratory group, and @entity5 group. RESULTS: 212 @entity0 with @entity4 were analyzed; advanced @entity2 and multiple @entity2 were found in 68 (32.0%) and 79 (37.2%) @entity0 . When compared to the nondrinker group (120/212 @entity0 ), the @entity1 drinker group (92/212 @entity0 ) represented significantly high odds ratios (ORs) for advanced @entity2 (OR, 2.697; P=0.002), and multiple @entity2 (OR, 1.929; P=0.039). Among @entity1 drinker (92 @entity0 ), the ORs of advanced @entity2 were 6.407 (P=0.003) in @entity5 group (17 @entity0 ), 3.711 (P=0.002) in the @entity1 drinker with abnormal lab (24 @entity0 ), and 2.184 (P=0.034), in the @entity1 drinker with normal lab (51 @entity0 ) compared to nondrinker group. CONCLUSIONS: This study showed that @entity1 drinking may influence on the development of advanced @entity4 and multiplicity. Especially in the group with @entity5 and with abnormal lab presented significantly higher ORs of advanced @entity2 .

title: XXXX drinking increased the risk of advanced @entity4 .

answer: @entity1


abstract: Mesenchymal stem cells (MSCs) have been proposed as a potential therapeutic tool for @entity5 ( @entity5 ) and systemic administration of these cells has been tested in preclinical and clinical studies. However, no information on survival and actual capacity of MSCs to reach the brain has been provided. In this study, we evaluated homing of intraarterially infused @entity1 MSCs (rMSCs) in the brain of @entity1 bearing a @entity8 ( @entity8 )-induced lesion of the nigrostriatal tract, to establish whether the toxin-induced damage is sufficient to grant MSC passage across the blood-brain barrier (BBB) or if a transient BBB disruption is necessary. The rMSC distribution in peripheral organs and the effects of cell infusion on neurodegenerative process and @entity2 were also investigated. rMSCs were infused 14 days after @entity8 injection. A hyperosmolar solution of @entity7 was used to transiently permeabilize the BBB. @entity4 was assessed by adjusting step test and response to @entity9 . Animals were sacrificed 7 and 28 days after cell infusion. Our work shows that appreciable delivery of rMSCs to the brain of @entity8 -lesioned animals can be obtained only after @entity7 pretreatment. A notable percentage of infused cells accumulated in peripheral organs. Infusion of rMSCs did not modify the progression of @entity8 -induced @entity0 at the stepping test, but induced progressive normalization of the pathological response (contralateral turning) to @entity9 administration. These findings suggest that many aspects should be further investigated before considering any translation of MSC systemic administration into the clinical setting for @entity5 treatment. SIGNIFICANCE: This study demonstrates that mesenchymal stem cells infused through the carotid artery do not efficiently cross the blood-brain barrier in @entity1 with a @entity6 , unless a permeabilizing agent (e.g., @entity7 ) is used. The infusion did not reduce the @entity6 and associated @entity3 , but abolished the motor abnormalities these animals typically show when challenged with a dopaminergic agonist. Therefore, although arterially infused mesenchymal stem cells did not show neurorestorative effects in this study's @entity5 model, they appeared to normalize the pathological responsiveness of striatal neurons to dopaminergic stimulation. This capability should be further explored in future studies.

title: Intracarotid Infusion of Mesenchymal Stem Cells in an Animal Model of XXXX , Focusing on Cell Distribution and Neuroprotective and Behavioral Effects.

answer: @entity5


abstract: UNASSIGNED: @entity3 miyamotoi, a member of the relapsing @entity0 group borreliae, was first isolated in Japan and subsequently found in Ixodes ticks in North America, Europe and Russia. Currently, there are three types of B. miyamotoi: Asian or Siberian (transmitted mainly by @entity2 ), European (Ixodesricinus) and American (Ixodesscapularis and Ixodespacificus). Despite the great genetic distances between B. miyamotoi types, isolates within a type are characterised by an extremely low genetic variability. In particular, strains of B. miyamotoi of Asian type, isolated in Russia from the Baltic sea to the Far East, have been shown to be identical based on the analysis of several conventional genetic markers, such as 16S rRNA, flagellin, outer membrane protein p66 and glpQ genes. Thus, protein or rRNA - coding genes were shown not to be informative enough in studying genetic diversity of B. miyamotoi within a type. In the present paper, we have attempted to design a new multilocus technique based on eight non-coding intergenic spacers (3686bp in total) and have applied it to the analysis of intra-type genetic variability of   . miyamotoi detected in different regions of Russia and from two tick species, @entity2 and Ixodespavlovskyi. However, even though potentially the most variable loci were selected, no genetic variability between studied DNA samples was found, except for one @entity1 substitution in two of them. The sequences obtained were identical to those of the reference strain FR64b. Analysis of the data obtained with the GenBank sequences indicates a highly homogeneous genetic background of B. miyamotoi from the Baltic Sea to the Japanese Islands. In this paper, a hypothesis of clonal expansion of B. miyamotoi is discussed, as well as possible mechanisms for the rapid dissemination of one B. miyamotoi clone over large distances.

title: Multilocus spacer analysis revealed highly homogeneous genetic background of Asian type of XXXX miyamotoi.

answer: @entity3


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a mosquito-transmitted Flavivirus belonging to the Japanese @entity1 antigenic complex of the Flaviviridae family. Its spread in the Mediterranean basin and the Balkans poses a significant risk to @entity0 health and forces public health officials to constantly monitor the virus transmission to ensure prompt application of preventive measures. In this context, predictive tools indicating the areas and periods at major risk of @entity3 transmission are of paramount importance. Spatial analysis approaches, which use environmental and climatic variables to find suitable habitats for @entity3 spread, can enhance predictive techniques. Using the Mahalanobis Distance statistic, areas ecologically most suitable for sustaining @entity3 transmission were identified in the Mediterranean basin and Central Europe. About 270 @entity0 and @entity2 clinical cases notified in Italy, Greece, Portugal, Morocco, and Tunisia, between 2008 and 2012, have been considered. The environmental variables included in the model were altitude, slope, night time Land Surface Temperature, Normalized Difference Vegetation Index, Enhanced Vegetation Index, and daily temperature range. Seasonality of mosquito population has been modelled and included in the analyses to produce monthly maps of suitable areas for @entity4 . Between May and July, the most suitable areas are located in Tunisia, Libya, Egypt, and North Cyprus. Summer/Autumn months, particularly between August and October, characterize the suitability in Italy, France, Spain, the Balkan countries, Morocco, North Tunisia, the Mediterranean coast of Africa, and the Middle East. The persistence of suitable conditions in December is confined to the coastal areas of Morocco, Tunisia, Libya, Egypt, and Israel.

title: Spatio-Temporal Identification of Areas Suitable for XXXX in the Mediterranean Basin and Central Europe.

answer: @entity4


abstract: UNASSIGNED: @entity4 ( @entity4 ) increases vulnerability for @entity5 ( @entity5 ). @entity4 is also associated with increased risk for developing @entity6 ( @entity6 ). Research has also documented a significant link between @entity5 and @entity6 ; however, there is a paucity of information examining this relationship among veterans with @entity4 -related @entity5 . In particular, we sought to examine whether comorbid @entity6 - @entity5 compared with veterans with @entity5 and no @entity6 resulted in increased @entity5 and @entity3 symptomatology. We also examined @entity2 , previous @entity4 , and demographic factors to determine what-if any-factors were associated with comorbid @entity6 diagnosis. Using data from a recently conducted randomized clinical trial, we examined electronic medical records of the local Veterans Affairs Medical Center. Data from 90 veterans with @entity4 -related @entity5 were obtained. More than 22% (n = 20) of the sample had a historical diagnosis of @entity6 . @entity0 were administered measures to assess @entity2 symptomatology ( @entity5 and @entity3 ), @entity1 -related negative cognitions (NCs), and previous sexual traumatization (e.g., childhood and civilian sexual exposure). An analysis of variance was conducted, which found that veterans with comorbid @entity4 -related @entity5 and @entity6 had significantly greater @entity5 criterion B (avoidance) symptoms, @entity3 symptomatology, and NC scores than @entity0 without comorbid @entity6 . In addition, a binary stepwise logistic regression found that veterans' @entity6 was also positively associated with NCs about self and the world; however, self-blame, @entity3 , @entity5 , sociodemographic variables (e.g., gender, age), and previous sexual traumatizations were not significant predictors. Implications are discussed with regard to clinical care and future research directions.

title: XXXX and @entity4 : Analysis of Previous Traumatization and Current Psychiatric Presentation.

answer: @entity6


abstract: UNASSIGNED: @entity4 ( @entity4 ) increases vulnerability for @entity5 ( @entity5 ). @entity4 is also associated with increased risk for developing @entity6 ( @entity6 ). Research has also documented a significant link between @entity5 and @entity6 ; however, there is a paucity of information examining this relationship among veterans with @entity4 -related @entity5 . In particular, we sought to examine whether comorbid @entity6 - @entity5 compared with veterans with @entity5 and no @entity6 resulted in increased @entity5 and @entity3 symptomatology. We also examined @entity2 , previous @entity4 , and demographic factors to determine what-if any-factors were associated with comorbid @entity6 diagnosis. Using data from a recently conducted randomized clinical trial, we examined electronic medical records of the local Veterans Affairs Medical Center. Data from 90 veterans with @entity4 -related @entity5 were obtained. More than 22% (n = 20) of the sample had a historical diagnosis of @entity6 . @entity0 were administered measures to assess @entity2 symptomatology ( @entity5 and @entity3 ), @entity1 -related negative cognitions (NCs), and previous sexual traumatization (e.g., childhood and civilian sexual exposure). An analysis of variance was conducted, which found that veterans with comorbid @entity4 -related @entity5 and @entity6 had significantly greater @entity5 criterion B (avoidance) symptoms, @entity3 symptomatology, and NC scores than @entity0 without comorbid @entity6 . In addition, a binary stepwise logistic regression found that veterans' @entity6 was also positively associated with NCs about self and the world; however, self-blame, @entity3 , @entity5 , sociodemographic variables (e.g., gender, age), and previous sexual traumatizations were not significant predictors. Implications are discussed with regard to clinical care and future research directions.

title: @entity6 and XXXX : Analysis of Previous Traumatization and Current Psychiatric Presentation.

answer: @entity4


abstract: PURPOSE: Non-traumatic spontaneous @entity5 of the rectus abdominal muscle is not considered a critical condition. Nevertheless, it can be a serious complication in some @entity0 due to continuous and/or consistent @entity2 . The most frequent cause of spontaneous rectus @entity1 is the anticoagulation therapy. The natural history of rectus @entity1 usually leads to a positive outcome and can be spontaneously self-limited only by conservative therapy. Nevertheless, in some @entity0 , despite a correct and early medical therapy, the continuous @entity2 requests a more radical handling. Up to now, the surgical @entity5 evacuation and the bonding of blood vessels were considered the most appropriate treatment, while at present, the percutaneous management by means of selective catheters and embolization of the @entity2 vessel is considered to be the most used option. Our purpose is to report our experience in the @entity1 treatment in the elderly @entity0 . MATERIALS AND METHODS: From the data base and medical reports of the hospital, we selected 144 medical reports. We focused on those cases that showed the following criteria: @entity0 with rectus @entity1 undergoing anticoagulation therapy and/or non-traumatic spontaneous @entity5 and with persistent @entity2 revealed on CT examination despite a pharmacological treatment aimed to timely reverse @entity3 . These criteria were found in 18 @entity0 : 15 females and 3 males, with a median age of 73 (range 64-81). In all @entity0 , the diagnosis had been confirmed by an abdominal CT in emergency setting, performed before and after contrast medium intravenous administration. Because of clinical conditions, all @entity0 had been moved on the angiographic room for diagnostic arteriography and embolization. The criteria for this treatment were @entity4 and the continuous @entity2 despite the correct medical therapy. RESULTS: CT imaging detected rectus @entity1 in 18/18 @entity0 and active @entity2 in 7/18 @entity0 . Selective catheterization was applied to all 18 @entity0 ; arteriographic study confirmed the information of the CT study in all of the seven @entity0 . The inferior epigastric artery was the main cause of the @entity2 in all 18 @entity0 . In 14 @entity0 , one single vessel was responsible for the @entity2 , while in the other four @entity0 , more than one vessel were involved: In two @entity0 , we also found the involvement of the superior epigastric artery; while the other two @entity0 showed also the involvement of the deep iliac circumflex artery. The material for embolization was compatible coils with micro-catheters in 17/18 @entity0 , and glue for 1/18 @entity0 . CONCLUSIONS: @entity0 with large rectus @entity1 , which have not yet recovered with conservative therapy, should then consider undergoing endovascular treatment. This procedure is highly recommended in @entity0 with other coexisting pathologies that could eventually lead to a fatal outcome. It is difficult to determine when surgery is necessary when there is very poor data provided by scientific literature review, so the decision to use surgery can be suggested when embolization is unsuccessful or when it is necessary to evacuate a complex huge fluid mass in peritoneal cavity.

title: Endovascular management of the rectus XXXX .

answer: @entity1


abstract: A new micellar electrokinetic chromatography (MEKC) method was developed and validated for the analysis of @entity4 and @entity3 in @entity0 urine samples. In this study, vortex-assisted liquid-liquid extraction (VALLE) coupled with field-amplified sample injection and sweeping was employed for biological sample clean-up and sensitivity enhancement in MEKC. After VALLE, the urine samples were analyzed by MEKC. @entity7 buffer (60mmolL(-1), pH 2.0) containing 40% (v/v) @entity2 was first filled into an uncoated fused- @entity6 capillary (56cm, 50  m i.d.). The pretreated urine sample was loaded by electrokinetic injection (10kV, 250s). The stacking and separation were performed using @entity7 buffer (30mmolL(-1), pH 3.0) containing 30% (v/v) @entity2 and 50mmolL(-1) @entity5 ( @entity1 ) at -25kV. Detection was carried out at 195 and 214nm for @entity4 and @entity3 , respectively. The suggested method is linear (r(2)>= 0.997) over a dynamic range of 0.005-1  gmL(-1) in urine. The intra- and inter-day relative standard deviation and relative error values of the method were below 20%, which shows good precision and accuracy. Finally, this method was successfully applied to the analysis of real urine samples.

title: Vortex-assisted liquid-liquid extraction combined with field-amplified sample injection and sweeping micellar electrokinetic chromatography for improved determination of b-blockers in XXXX urine.

answer: @entity0


abstract: @entity0 black-streaked dwarf disease, caused by @entity2 ), is transmitted by @entity1 ( @entity1 Fall  n, SBPH) and causes severe yield loss in epidemic years in China and other East Asian countries. Breeding for resistance to @entity2 is a promising strategy to control the disease. We identified Tetep that showed resistance to @entity2 using a field test and artificial inoculation test. An evaluation of the resistance mechanism revealed that Tetep was resistant to @entity2 but not to SBPH. Genetic analysis showed that the resistance of Tetep to @entity2 was controlled by quantitative trait loci (QTLs). Three new QTLs for @entity2 resistance were identified in this study, i.e., qRBSDV-3, qRBSDV-10 and qRBSDV-11. The LOD scores of qRBSDV-3, qRBSDV-10 and qRBSDV-11 were 4.07, 2.24 and 2.21, accounting for 17.5%, 0.3% and 12.4% of the total phenotypic variation, respectively. All the resistance loci identified in this study were associated with virus resistance genes. The alleles for enhancing resistance on chromosomes 3 and 11 originated from Tetep, whereas the other allele on chromosome 10 originated from a susceptible parent. The identified new resistance QTLs in this study are useful resources for efficiently breeding resistant @entity0 cultivars to @entity2 .

title: Genetic analysis and molecular mapping of QTLs for resistance to XXXX black-streaked dwarf disease in @entity0 .

answer: @entity0


abstract: @entity0 black-streaked dwarf disease, caused by @entity2 ), is transmitted by @entity1 ( @entity1 Fall  n, SBPH) and causes severe yield loss in epidemic years in China and other East Asian countries. Breeding for resistance to @entity2 is a promising strategy to control the disease. We identified Tetep that showed resistance to @entity2 using a field test and artificial inoculation test. An evaluation of the resistance mechanism revealed that Tetep was resistant to @entity2 but not to SBPH. Genetic analysis showed that the resistance of Tetep to @entity2 was controlled by quantitative trait loci (QTLs). Three new QTLs for @entity2 resistance were identified in this study, i.e., qRBSDV-3, qRBSDV-10 and qRBSDV-11. The LOD scores of qRBSDV-3, qRBSDV-10 and qRBSDV-11 were 4.07, 2.24 and 2.21, accounting for 17.5%, 0.3% and 12.4% of the total phenotypic variation, respectively. All the resistance loci identified in this study were associated with virus resistance genes. The alleles for enhancing resistance on chromosomes 3 and 11 originated from Tetep, whereas the other allele on chromosome 10 originated from a susceptible parent. The identified new resistance QTLs in this study are useful resources for efficiently breeding resistant @entity0 cultivars to @entity2 .

title: Genetic analysis and molecular mapping of QTLs for resistance to @entity0 black-streaked dwarf disease in XXXX .

answer: @entity0


abstract: PURPOSE: To evaluate an @entity2 for @entity3 . METHODS: Nine @entity0 (5 @entity0 and 4 @entity0 aged 6 to 13 years) with @entity3 were treated with @entity2 . Magnetic resonance imaging of the elbow showed the proximal radioulnar joint on the anterior-lateral side of the ulna rather than on the lateral side in @entity0 with @entity3 . On the basis of this finding, we performed an osteotomy on the ulna and laterally rotated the proximal radioulnar joint achieving radial head reduction and restoring the anatomical relationship between the radial head and the capitellum. Clinical and radiographical evaluation of the elbow was performed before surgery and at postoperative follow-up. RESULTS: All @entity0 were followed for 13 to 45 months after surgery. Elbow radiography showed that the radiocapitellar joint was reduced in all @entity0 at the last follow-up visit and that the carrying angle was decreased relative to that in the preoperative condition. Elbow stability and the range of @entity4 were improved at the last follow-up. We did not observe ulnar osteotomy site nonunion or @entity1 in these @entity0 . Furthermore, @entity3 did not recur. CONCLUSIONS: At early follow-up, @entity2 was a safe and effective method for the treatment of @entity3 . TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.

title: Ulnar Rotation Osteotomy for Congenital XXXX .

answer: @entity3


abstract: UNASSIGNED: The objective of this study was to investigate the relationship between IGFs produced in the liver and skeletal muscle with @entity1 previously observed in a line of GH-transgenic @entity2 . In this sense, we evaluated the expression of genes related to the IGF system in liver and muscle of transgenics, as well as the main intracellular signaling pathways used by GH/IGF axis. Our results showed an increase in expression of @entity3 , @entity4 , and @entity5 genes in the liver. Moreover, there was a decrease in the expression of @entity6 and an increase in muscle igf2r of transgenics, indicating a negative response of muscle tissue with respect to excess circulating IGFs. Muscle IGFs expression analyses revealed a significant increase only for @entity5 , accompanied by a parallel induction of @entity8 gene. The presence of @entity8 may potentiate the @entity4 action in muscle cells differentiation. Regarding JAK/ @entity9 -related genes, we observed an alteration in the expression profile of both @entity7 and @entity10 in transgenic fish liver. No changes were observed in the muscle, suggesting that both tissues respond differently to GH-transgenesis. Western blotting analyses indicated an imbalance between the phosphorylation levels of the proliferative (MEK/ERK) and @entity0 (PI3K/Akt) pathways, in favor of the latter. In summary, the results of this study suggest that the @entity0 caused by GH-transgenesis in @entity2 may be due to circulating IGFs produced by the liver, with an important participation of muscle @entity5 . This group of IGFs appears to be favoring the @entity0 intracellular pathway in muscle tissue of transgenic @entity2 .

title: Expression profile of IGF paralog genes in liver and muscle of a GH-transgenic XXXX .

answer: @entity2


abstract: A few reports have provided histopathological insight into @entity3 developing after antitumor chemotherapy. In general, @entity5 is a commonly observed finding in @entity0 with severe @entity3 . We herein report a novel pathological finding that may characterize the histopathological change occurring in @entity0 with @entity3 after chemotherapy for @entity1 . Lung biopsy or autopsy was performed in 7 @entity0 with @entity3 that developed during or after chemotherapy between 2006 and 2013 to examine the pulmonary vascular changes or to determine the cause of @entity4 . Pathological findings included in situ @entity6 in the small pulmonary arteries in 4 of 7 @entity0 . In 2 of 4 @entity0 , @entity3 was controlled by anticoagulants and antithrombotic agents. One @entity0 who had organized thrombi attained spontaneous remission with @entity2 therapy. The other @entity0 died of sudden @entity7 during chemotherapy. Autopsy showed complete occlusion of the peripheral small pulmonary arteries and veins by thrombi. These results demonstrate that in situ @entity6 in the small pulmonary arteries could cause @entity3 after chemotherapy.

title: In situ @entity6 of small pulmonary arteries in XXXX developing after chemotherapy for @entity1 .

answer: @entity3


abstract: A few reports have provided histopathological insight into @entity3 developing after antitumor chemotherapy. In general, @entity5 is a commonly observed finding in @entity0 with severe @entity3 . We herein report a novel pathological finding that may characterize the histopathological change occurring in @entity0 with @entity3 after chemotherapy for @entity1 . Lung biopsy or autopsy was performed in 7 @entity0 with @entity3 that developed during or after chemotherapy between 2006 and 2013 to examine the pulmonary vascular changes or to determine the cause of @entity4 . Pathological findings included in situ @entity6 in the small pulmonary arteries in 4 of 7 @entity0 . In 2 of 4 @entity0 , @entity3 was controlled by anticoagulants and antithrombotic agents. One @entity0 who had organized thrombi attained spontaneous remission with @entity2 therapy. The other @entity0 died of sudden @entity7 during chemotherapy. Autopsy showed complete occlusion of the peripheral small pulmonary arteries and veins by thrombi. These results demonstrate that in situ @entity6 in the small pulmonary arteries could cause @entity3 after chemotherapy.

title: In situ @entity6 of small pulmonary arteries in @entity3 developing after chemotherapy for XXXX .

answer: @entity1


abstract: A few reports have provided histopathological insight into @entity3 developing after antitumor chemotherapy. In general, @entity5 is a commonly observed finding in @entity0 with severe @entity3 . We herein report a novel pathological finding that may characterize the histopathological change occurring in @entity0 with @entity3 after chemotherapy for @entity1 . Lung biopsy or autopsy was performed in 7 @entity0 with @entity3 that developed during or after chemotherapy between 2006 and 2013 to examine the pulmonary vascular changes or to determine the cause of @entity4 . Pathological findings included in situ @entity6 in the small pulmonary arteries in 4 of 7 @entity0 . In 2 of 4 @entity0 , @entity3 was controlled by anticoagulants and antithrombotic agents. One @entity0 who had organized thrombi attained spontaneous remission with @entity2 therapy. The other @entity0 died of sudden @entity7 during chemotherapy. Autopsy showed complete occlusion of the peripheral small pulmonary arteries and veins by thrombi. These results demonstrate that in situ @entity6 in the small pulmonary arteries could cause @entity3 after chemotherapy.

title: In situ XXXX of small pulmonary arteries in @entity3 developing after chemotherapy for @entity1 .

answer: @entity6


abstract: A case of 19-year-old male @entity0 reported with the chief complaint of slowly growing diffuse @entity1 over the right part of the face from last 6 months. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Radiographic examination (orthopantograph and 3DCT) showed large multilocular radiolucency in right maxilla with generalized @entity5 . Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 15-30 nuclei. Based on clinical, radiological, and histopathological findings provisional diagnosis of @entity9 was made. Blood tests after histopathology demonstrated elevated serum @entity7 level and alkaline phosphatase level. Immunoassay of @entity8 ( @entity8 ) level was found to be highly elevated. Radiographic examination of long bones like humerus and femur, mandible, and skull was also done which showed @entity3 . Considering the clinical, radiographic, histopathological, and blood investigation findings, final diagnosis of @entity2 of maxilla was made. The @entity0 underwent partial parathyroidectomy under general anaesthesia to control @entity6 . Surgical @entity3 was done by curettage. The @entity0 has been followed up for 1 year with no @entity4 and the lesion healed uneventfully.

title: @entity9 : first expression of XXXX .

answer: @entity6


abstract: A case of 19-year-old male @entity0 reported with the chief complaint of slowly growing diffuse @entity1 over the right part of the face from last 6 months. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Radiographic examination (orthopantograph and 3DCT) showed large multilocular radiolucency in right maxilla with generalized @entity5 . Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 15-30 nuclei. Based on clinical, radiological, and histopathological findings provisional diagnosis of @entity9 was made. Blood tests after histopathology demonstrated elevated serum @entity7 level and alkaline phosphatase level. Immunoassay of @entity8 ( @entity8 ) level was found to be highly elevated. Radiographic examination of long bones like humerus and femur, mandible, and skull was also done which showed @entity3 . Considering the clinical, radiographic, histopathological, and blood investigation findings, final diagnosis of @entity2 of maxilla was made. The @entity0 underwent partial parathyroidectomy under general anaesthesia to control @entity6 . Surgical @entity3 was done by curettage. The @entity0 has been followed up for 1 year with no @entity4 and the lesion healed uneventfully.

title: XXXX : first expression of @entity6 .

answer: @entity9


abstract: BACKGROUND/AIMS: The role of Billroth I (BI) subtotal gastrectomy (SG) for @entity2 ( @entity2 ) remains controversial in Western countries. The aim of the study is to critically analyze the long term outcomes of this procedure in a large single-institution experience. METHODOLOGY: Between 1990 and 2004, 158 @entity0 underwent BI SG for @entity2 at the Regina Elena Cancer Institute of Rome. Evaluation focused on @entity1 recurrence of the @entity2 , functional outcome and endoscopic findings. RESULTS: Actuarial survival rate 10 years after resection in stage I-II was 70.7 per cent. After curative resection, primary @entity2 occurred in one @entity0 seven years after resection (0.7 per cent), whereas two @entity0 had early recurrence (1.4 per cent) one and three years postoperatively. There were no oesophageal @entity1 . In survivors, Visick grades I and II achieved 95 per cent, and postoperative endoscopy showed no evidence of mucosal changes in 85 per cent of the @entity0 . Twelve per cent of the @entity0 took acid blocker regularly, however, the incidence of functional failure was 5 per cent. CONCLUSIONS: In selected @entity0 , Billroth I subtotal gastrectomy is a safe and effective procedure that provides long-term survival and very good functional outcome.

title: XXXX : long term outcomes of Billroth I reconstruction at a single European institute.

answer: @entity2