abstract: The frequency of peripheral @entity3 in the upper extremities is much less than in the lower extremities. Diagnosis and surgical treatment are important because upper extremity @entity4 can cause severe decreases in function and lead to the loss of an arm or of fingers. We performed aneurysmal resection together with saphenous vein graft interpositioning in 9 @entity0 with a diagnosis of post-traumatic @entity6 from January 1995 through February 2003. Of these @entity0 , 7 were @entity0 (77%). The mean age was 38.2 years (range, 26-46 years. Four @entity0 had gunshot wounds (44%) and 5 had stab wounds (56%). The mean duration from injury to hospital admission was 26.7 months (range, 17 months-7 years). All @entity0 underwent color-flow arterial Doppler ultrasonography and selective upper extremity digital subtraction angiography. In all @entity0 , we performed aneurysmal resection and saphenous vein graft interpositioning. There was no instance of @entity2 or @entity1 extremity loss. @entity0 were discharged from the hospital a mean of 3.2 days after surgery (range, 2-6 days). Early and late graft patency rates were 100%. We followed the @entity0 ' cases for a mean of 3.4 years (range, 1 month-7 years). Very rarely, post-traumatic upper extremity @entity5 after a long period of time. Diagnosis is very easy with a review of the @entity0 's history and a physical examination; surgical reconstruction is the preferred treatment for such @entity0 .

title: Post-traumatic XXXX and its surgical treatment.

answer: @entity6


abstract: A clinical study was performed investigating the ability of intravenous @entity4 to cause @entity5 for @entity3 stimuli presented during surgical removal of third molars. Various stimuli were presented prior to and after administration of a sufficient quantity of @entity4 to produce profound sedation. Recall was then tested immediately after, one day, and one week following the surgery. The study found that @entity4 produces at least 20 minutes of profound @entity5 for all stimuli in 93 +/- 6% of individuals. However, little correlation was found between the dose of @entity4 and the duration of @entity5 . Anesthesia literally means the loss of sensation. In the clinical dental situation, the principle sensation lost, when using either regional or general anesthesia, is @entity2 perception. Although prevention of @entity2 sensation is the primary reason @entity0 request local anesthesia prior to invasive dental care, for many @entity0 , control of @entity2 only partially prepares them to receive dental care. These @entity0 request the adjunctive use of sedation or general anesthesia, not for @entity2 control, but rather requiring periodontal or oral/maxillofacial surgery in which such factors as the sight and taste of blood, the noise of bone-cutting equipment, or the pressure placed on the jaws is not eliminated by local anesthetics. Although effective anxiolytic oral, inhalational, or parenteral agents have been available for several decades, @entity0 still usually retain their memory of events occurring during their dental care, particularly @entity1 -provoking events. This memory of the uncomfortable portions of dental care stimulates additional @entity1 so that @entity0 may procrastinate when dental care is necessary.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Intensity and duration of XXXX from intravenous @entity4 given for sedation.

answer: @entity5


abstract: A clinical study was performed investigating the ability of intravenous @entity4 to cause @entity5 for @entity3 stimuli presented during surgical removal of third molars. Various stimuli were presented prior to and after administration of a sufficient quantity of @entity4 to produce profound sedation. Recall was then tested immediately after, one day, and one week following the surgery. The study found that @entity4 produces at least 20 minutes of profound @entity5 for all stimuli in 93 +/- 6% of individuals. However, little correlation was found between the dose of @entity4 and the duration of @entity5 . Anesthesia literally means the loss of sensation. In the clinical dental situation, the principle sensation lost, when using either regional or general anesthesia, is @entity2 perception. Although prevention of @entity2 sensation is the primary reason @entity0 request local anesthesia prior to invasive dental care, for many @entity0 , control of @entity2 only partially prepares them to receive dental care. These @entity0 request the adjunctive use of sedation or general anesthesia, not for @entity2 control, but rather requiring periodontal or oral/maxillofacial surgery in which such factors as the sight and taste of blood, the noise of bone-cutting equipment, or the pressure placed on the jaws is not eliminated by local anesthetics. Although effective anxiolytic oral, inhalational, or parenteral agents have been available for several decades, @entity0 still usually retain their memory of events occurring during their dental care, particularly @entity1 -provoking events. This memory of the uncomfortable portions of dental care stimulates additional @entity1 so that @entity0 may procrastinate when dental care is necessary.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Intensity and duration of @entity5 from intravenous XXXX given for sedation.

answer: @entity4


abstract: OBJECTIVE: To study the incidence of @entity1 in a defined population in Finland. METHODS: We collected data for the year 2000 on a population of 87,000 inhabitants of Kuopio, Finland, of whom 20% were < 16 years of age. Information about the study was given through a local newspaper, and subjects attended one health center and 2 local hospitals for study. Inclusion criteria were that subjects have at least one peripheral joint with @entity3 or signs of @entity1 in sacroiliac, glenohumeral, or hip joints on the first visit. Incidence rates were calculated according to the diagnosis on the first visit, except for @entity0 , for whom diagnoses were established after 3 months' followup. RESULTS: A total of 188 adult incident cases (138 @entity0 , 50 @entity0 ) and 11 @entity0 (8 @entity0 , 3 @entity0 ) satisfied the inclusion criteria. The incidence of all @entity4 was 230/100,000 (95% confidence interval 198.9-263.9) for the whole population; 271/100,000 (95% CI 233.7-312.7) for adults and 64/100,000 (95% CI 31.7-113.8) for @entity0 . Among adults the annual incidence of @entity2 ( @entity2 ), @entity6 ( @entity6 ), @entity8 ( @entity8 ), @entity4 ( @entity4 ), other @entity9 ( @entity9 ), connective tissue disease (CTD), @entity4 , @entity10 , and undifferentiated @entity4 were 36, 7, 23, 10, 13, 9, 19, 7, and 149/100,000, respectively. The mean age at diagnosis was 49.4 +/- 16.3 years for all cases of @entity4 among adults, about the same for both @entity0 and @entity0 . The mean age at diagnosis was 59.7 years in @entity2 , 31.5 years in @entity6 , 48.7 years in @entity8 , 38.0 years in @entity4 , 36.5 years in other @entity9 , 36.1 years in CTD, 65.0 years in @entity4 , 53.3 years in @entity10 , and 48.3 years in undifferentiated @entity4 . Four of 11 @entity0 had @entity7 ( @entity7 ). The incidence of @entity7 was 23/100,000 in the population < 16 years of age. Of the remaining cases, 3 children had antibodies against @entity5 and 4 had a transient monoarthritis. CONCLUSION: The overall incidence of @entity4 among adults was slightly higher than previously reported from Finland. The incidence rates in the @entity0 population are in agreement with previous figures. These data are useful in planning the provision of health care.

title: Total incidence and distribution of @entity1 in a defined population: results from the Kuopio 2000 XXXX survey.

answer: @entity4


abstract: OBJECTIVE: To study the incidence of @entity1 in a defined population in Finland. METHODS: We collected data for the year 2000 on a population of 87,000 inhabitants of Kuopio, Finland, of whom 20% were < 16 years of age. Information about the study was given through a local newspaper, and subjects attended one health center and 2 local hospitals for study. Inclusion criteria were that subjects have at least one peripheral joint with @entity3 or signs of @entity1 in sacroiliac, glenohumeral, or hip joints on the first visit. Incidence rates were calculated according to the diagnosis on the first visit, except for @entity0 , for whom diagnoses were established after 3 months' followup. RESULTS: A total of 188 adult incident cases (138 @entity0 , 50 @entity0 ) and 11 @entity0 (8 @entity0 , 3 @entity0 ) satisfied the inclusion criteria. The incidence of all @entity4 was 230/100,000 (95% confidence interval 198.9-263.9) for the whole population; 271/100,000 (95% CI 233.7-312.7) for adults and 64/100,000 (95% CI 31.7-113.8) for @entity0 . Among adults the annual incidence of @entity2 ( @entity2 ), @entity6 ( @entity6 ), @entity8 ( @entity8 ), @entity4 ( @entity4 ), other @entity9 ( @entity9 ), connective tissue disease (CTD), @entity4 , @entity10 , and undifferentiated @entity4 were 36, 7, 23, 10, 13, 9, 19, 7, and 149/100,000, respectively. The mean age at diagnosis was 49.4 +/- 16.3 years for all cases of @entity4 among adults, about the same for both @entity0 and @entity0 . The mean age at diagnosis was 59.7 years in @entity2 , 31.5 years in @entity6 , 48.7 years in @entity8 , 38.0 years in @entity4 , 36.5 years in other @entity9 , 36.1 years in CTD, 65.0 years in @entity4 , 53.3 years in @entity10 , and 48.3 years in undifferentiated @entity4 . Four of 11 @entity0 had @entity7 ( @entity7 ). The incidence of @entity7 was 23/100,000 in the population < 16 years of age. Of the remaining cases, 3 children had antibodies against @entity5 and 4 had a transient monoarthritis. CONCLUSION: The overall incidence of @entity4 among adults was slightly higher than previously reported from Finland. The incidence rates in the @entity0 population are in agreement with previous figures. These data are useful in planning the provision of health care.

title: Total incidence and distribution of XXXX in a defined population: results from the Kuopio 2000 @entity4 survey.

answer: @entity1


abstract: The study examined perceptions, practices and norms underlying sexuality and gender relations that constrain the prevention and control of STIs and @entity2 / @entity3 . It was carried out among the Igbo of Awka and Agulu in Anambra State of Nigeria. Both quantitative and qualitative methods were used for data collection. Findings indicate that cultural practices that encourage the establishment of @entity1 by @entity0 persist in the study communities. Some married @entity0 who are not able to achieve pregnancy with their husbands get involved in such networks to have @entity0 . Some parents who do not have male @entity0 encourage their unmarried daughters to have @entity0 out of wedlock so as to perpetuate the lineage. Inequality in gender relations and fear of repercussions constrain @entity0 from negotiating safe sex. Sexuality education is, therefore, necessary to improve the knowledge base, perceptions and sexual behaviours of the study communities. @entity0 should be empowered to make informed decisions about sexuality and childbearing. Male responsibility in reproductive health should also be encouraged.

title: Gender issues in the prevention and control of STIs and @entity2 / XXXX : lessons from Awka and Agulu, Anambra State, Nigeria.

answer: @entity3


abstract: The study examined perceptions, practices and norms underlying sexuality and gender relations that constrain the prevention and control of STIs and @entity2 / @entity3 . It was carried out among the Igbo of Awka and Agulu in Anambra State of Nigeria. Both quantitative and qualitative methods were used for data collection. Findings indicate that cultural practices that encourage the establishment of @entity1 by @entity0 persist in the study communities. Some married @entity0 who are not able to achieve pregnancy with their husbands get involved in such networks to have @entity0 . Some parents who do not have male @entity0 encourage their unmarried daughters to have @entity0 out of wedlock so as to perpetuate the lineage. Inequality in gender relations and fear of repercussions constrain @entity0 from negotiating safe sex. Sexuality education is, therefore, necessary to improve the knowledge base, perceptions and sexual behaviours of the study communities. @entity0 should be empowered to make informed decisions about sexuality and childbearing. Male responsibility in reproductive health should also be encouraged.

title: Gender issues in the prevention and control of STIs and XXXX / @entity3 : lessons from Awka and Agulu, Anambra State, Nigeria.

answer: @entity2


abstract: BACKGROUND: Success in the treatment of @entity6 during infancy depends on an accurate early diagnosis and a correct therapeutic management. Current available resources can be divided into pharmacologic, endovascular, surgical, and laser. Results are variable, and complications should always be kept in mind. METHODS: We reviewed all @entity0 with @entity6 who suffered from major complications directly due to the treatment during the past five years. RESULTS: 1. A @entity0 with an upper @entity14 following treatment with interferon after no response to @entity4 . A long-term severe neutropoenia forced to an early surgical excision of the lesion. 2. A @entity0 suffering from an orbitary @entity11 with severe exoftalmus was treated with interferon because of a @entity3 -resistance. A @entity5 due to interferon reverted after treatment was discontinued. 3. In a @entity0 with a Blue-Rubber @entity15 , extended @entity10 was performed. She developed @entity1 of the left leg and a permanent @entity13 . 4. In a @entity0 with an @entity12 on the right leg and gluteous, a femoral artery endoprosthesis was placed because of a @entity7 . She underwent a total excision of the @entity8 and developed a recurrent @entity2 related to a femoral @entity9 . Finally a foot amputation was needed. 5. A @entity0 with a Kaposi-like @entity17 who was following a high-dose prolonged @entity3 therapy died because of a @entity16 related to a severe immunosuppression. CONCLUSIONS: Treatment of @entity6 during childhood need an early accurate diagnosis. If a right therapeutic sequence is not performed, useful drugs can turn into inefficient or dangerous. Most treatment complications in these @entity0 can be avoided.

title: [Severe complications in the treatment of XXXX ].

answer: @entity6


abstract: 1. @entity3 is a multifactorial, inflammatory disease of the arterial vessel wall that is promoted by various well-defined risk factors. Although numerous genes, expressed in different vascular and inflammatory cells, have been implicated in this disease, it is widely appreciated that most of the genes and gene products vital for initiation and progression of @entity3 are unknown. 2. We follow two strategies in an attempt to make up for the void of essential knowledge. First, we study candidate genes that have not been implied in @entity0 @entity3 before, notably the differentiation factor @entity2 A. 3. Second, we performed a genome-wide search by differential display reverse transcription-polymerase chain reaction. This study indicated potential involvement of the @entity5 orphan receptor transcription factor in @entity4 ( @entity4 ) (patho)physiology. 4. To reveal functional involvement of these proteins in @entity4 during @entity3 , we performed experiments with @entity1 models, adjusted either to the characteristics of a secreted protein or to that of an intracellular transcription factor. 5. The secreted protein @entity2 A was studied in @entity1 infected systemically with recombinant adenoviral vehicles, resulting in predominant hepatic expression and subsequent high protein levels in the circulation. 6. To study the role of @entity5 in @entity3 , we generated @entity1 in which promoter sequences were applied that direct expression of the transgenes to @entity4 of the arterial tree. 7. Two approaches were taken to induce the formation of @entity4 -rich lesions: (i) activation of femoral artery @entity4 by placement of a loosely fitting cuff; and (ii) ligation of the carotid artery. 8. The aim of the present review is to illustrate the different approaches that can be taken to assess the potential relevance of genes in @entity3 in carefully selected @entity1 models. 9. Based on the results described, we propose that both @entity2 A and @entity5 prevent excessive @entity4 proliferation.

title: @entity2 and XXXX orphan receptor: two 'atheroprotective' genes as evidenced in dedicated @entity1 models.

answer: @entity5


abstract: 1. @entity3 is a multifactorial, inflammatory disease of the arterial vessel wall that is promoted by various well-defined risk factors. Although numerous genes, expressed in different vascular and inflammatory cells, have been implicated in this disease, it is widely appreciated that most of the genes and gene products vital for initiation and progression of @entity3 are unknown. 2. We follow two strategies in an attempt to make up for the void of essential knowledge. First, we study candidate genes that have not been implied in @entity0 @entity3 before, notably the differentiation factor @entity2 A. 3. Second, we performed a genome-wide search by differential display reverse transcription-polymerase chain reaction. This study indicated potential involvement of the @entity5 orphan receptor transcription factor in @entity4 ( @entity4 ) (patho)physiology. 4. To reveal functional involvement of these proteins in @entity4 during @entity3 , we performed experiments with @entity1 models, adjusted either to the characteristics of a secreted protein or to that of an intracellular transcription factor. 5. The secreted protein @entity2 A was studied in @entity1 infected systemically with recombinant adenoviral vehicles, resulting in predominant hepatic expression and subsequent high protein levels in the circulation. 6. To study the role of @entity5 in @entity3 , we generated @entity1 in which promoter sequences were applied that direct expression of the transgenes to @entity4 of the arterial tree. 7. Two approaches were taken to induce the formation of @entity4 -rich lesions: (i) activation of femoral artery @entity4 by placement of a loosely fitting cuff; and (ii) ligation of the carotid artery. 8. The aim of the present review is to illustrate the different approaches that can be taken to assess the potential relevance of genes in @entity3 in carefully selected @entity1 models. 9. Based on the results described, we propose that both @entity2 A and @entity5 prevent excessive @entity4 proliferation.

title: XXXX and @entity5 orphan receptor: two 'atheroprotective' genes as evidenced in dedicated @entity1 models.

answer: @entity2


abstract: 1. @entity3 is a multifactorial, inflammatory disease of the arterial vessel wall that is promoted by various well-defined risk factors. Although numerous genes, expressed in different vascular and inflammatory cells, have been implicated in this disease, it is widely appreciated that most of the genes and gene products vital for initiation and progression of @entity3 are unknown. 2. We follow two strategies in an attempt to make up for the void of essential knowledge. First, we study candidate genes that have not been implied in @entity0 @entity3 before, notably the differentiation factor @entity2 A. 3. Second, we performed a genome-wide search by differential display reverse transcription-polymerase chain reaction. This study indicated potential involvement of the @entity5 orphan receptor transcription factor in @entity4 ( @entity4 ) (patho)physiology. 4. To reveal functional involvement of these proteins in @entity4 during @entity3 , we performed experiments with @entity1 models, adjusted either to the characteristics of a secreted protein or to that of an intracellular transcription factor. 5. The secreted protein @entity2 A was studied in @entity1 infected systemically with recombinant adenoviral vehicles, resulting in predominant hepatic expression and subsequent high protein levels in the circulation. 6. To study the role of @entity5 in @entity3 , we generated @entity1 in which promoter sequences were applied that direct expression of the transgenes to @entity4 of the arterial tree. 7. Two approaches were taken to induce the formation of @entity4 -rich lesions: (i) activation of femoral artery @entity4 by placement of a loosely fitting cuff; and (ii) ligation of the carotid artery. 8. The aim of the present review is to illustrate the different approaches that can be taken to assess the potential relevance of genes in @entity3 in carefully selected @entity1 models. 9. Based on the results described, we propose that both @entity2 A and @entity5 prevent excessive @entity4 proliferation.

title: @entity2 and @entity5 orphan receptor: two 'atheroprotective' genes as evidenced in dedicated XXXX models.

answer: @entity1


abstract: AIMS: The relationship between @entity6 polymorphisms at positions 16 and 27, and the acute systemic @entity6 effects of inhaled @entity8 is unclear. We therefore elected to evaluate the influence of common homozygous @entity6 haplotypes on the acute systemic @entity6 effects following inhaled @entity8 in @entity3 subjects. METHODS: An initial database search of 531 @entity3 subjects identified the two commonest homozygous haplotypes at positions 16 and 27 to be @entity2 16-Gln27 (12%) and @entity9 16- @entity1 27 (19%). After a 1-week washout period where all @entity6 agonists were withdrawn, 16 Caucasian subjects ( @entity2 16-Gln27: n = 8 and Gly16- @entity1 27: n = 8) were given a single dose of inhaled @entity8 (1200 microg), followed by serial blood sampling for serum @entity4 , along with measurements of diastolic blood pressure and heart rate, at 5-min intervals for 20 min. RESULTS: The two groups were well matched for age, sex, FEV1, and inhaled @entity0 dose. Baseline values for serum @entity4 , diastolic blood pressure and heart rate were not significantly different comparing @entity2 16-Gln27 vs Gly16- @entity1 27. The mean +/- SEM maximum serum @entity4 change from baseline over 20 min was significantly greater (P = 0.04) for @entity2 16-Gln27: -0.37 +/- 0.05 mmol l(-1) vs Gly16- @entity1 27: -0.23 +/- 0.04 mmol l(-1); 95% CI for difference: -0.01 to -0.28 mmol l(-1). The maximum diastolic blood pressure change from baseline over 20 min was significantly greater (P = 0.0008) for @entity2 16-Gln27: -13 +/- 1 mmHg vs Gly16- @entity1 27: -4 +/- 2 mmHg; 95% CI for difference: -5, 14 mmHg. There was no significant difference comparing the maximum heart rate change from baseline for @entity2 16-Gln27: 10 +/- 3 beats @entity5 ) vs Gly16- @entity1 27: 10 +/- 3 beats @entity5 ). CONCLUSIONS: Caucasian @entity3 subjects with the @entity2 16-Gln27 haplotype exhibited a greater systemic response to inhaled @entity8 , compared with those with the @entity9 16- @entity1 27 haplotype. The attenuated @entity6 response in the Gly16-Glu27 haplotype would be in keeping with increased susceptibility to prior down-regulation by endogenous @entity7 .

title: Acute systemic effects of inhaled XXXX in @entity3 subjects expressing common homozygous @entity6 haplotypes at positions 16 and 27.

answer: @entity8


abstract: AIMS: The relationship between @entity6 polymorphisms at positions 16 and 27, and the acute systemic @entity6 effects of inhaled @entity8 is unclear. We therefore elected to evaluate the influence of common homozygous @entity6 haplotypes on the acute systemic @entity6 effects following inhaled @entity8 in @entity3 subjects. METHODS: An initial database search of 531 @entity3 subjects identified the two commonest homozygous haplotypes at positions 16 and 27 to be @entity2 16-Gln27 (12%) and @entity9 16- @entity1 27 (19%). After a 1-week washout period where all @entity6 agonists were withdrawn, 16 Caucasian subjects ( @entity2 16-Gln27: n = 8 and Gly16- @entity1 27: n = 8) were given a single dose of inhaled @entity8 (1200 microg), followed by serial blood sampling for serum @entity4 , along with measurements of diastolic blood pressure and heart rate, at 5-min intervals for 20 min. RESULTS: The two groups were well matched for age, sex, FEV1, and inhaled @entity0 dose. Baseline values for serum @entity4 , diastolic blood pressure and heart rate were not significantly different comparing @entity2 16-Gln27 vs Gly16- @entity1 27. The mean +/- SEM maximum serum @entity4 change from baseline over 20 min was significantly greater (P = 0.04) for @entity2 16-Gln27: -0.37 +/- 0.05 mmol l(-1) vs Gly16- @entity1 27: -0.23 +/- 0.04 mmol l(-1); 95% CI for difference: -0.01 to -0.28 mmol l(-1). The maximum diastolic blood pressure change from baseline over 20 min was significantly greater (P = 0.0008) for @entity2 16-Gln27: -13 +/- 1 mmHg vs Gly16- @entity1 27: -4 +/- 2 mmHg; 95% CI for difference: -5, 14 mmHg. There was no significant difference comparing the maximum heart rate change from baseline for @entity2 16-Gln27: 10 +/- 3 beats @entity5 ) vs Gly16- @entity1 27: 10 +/- 3 beats @entity5 ). CONCLUSIONS: Caucasian @entity3 subjects with the @entity2 16-Gln27 haplotype exhibited a greater systemic response to inhaled @entity8 , compared with those with the @entity9 16- @entity1 27 haplotype. The attenuated @entity6 response in the Gly16-Glu27 haplotype would be in keeping with increased susceptibility to prior down-regulation by endogenous @entity7 .

title: Acute systemic effects of inhaled @entity8 in @entity3 subjects expressing common homozygous XXXX haplotypes at positions 16 and 27.

answer: @entity6


abstract: AIMS: The relationship between @entity6 polymorphisms at positions 16 and 27, and the acute systemic @entity6 effects of inhaled @entity8 is unclear. We therefore elected to evaluate the influence of common homozygous @entity6 haplotypes on the acute systemic @entity6 effects following inhaled @entity8 in @entity3 subjects. METHODS: An initial database search of 531 @entity3 subjects identified the two commonest homozygous haplotypes at positions 16 and 27 to be @entity2 16-Gln27 (12%) and @entity9 16- @entity1 27 (19%). After a 1-week washout period where all @entity6 agonists were withdrawn, 16 Caucasian subjects ( @entity2 16-Gln27: n = 8 and Gly16- @entity1 27: n = 8) were given a single dose of inhaled @entity8 (1200 microg), followed by serial blood sampling for serum @entity4 , along with measurements of diastolic blood pressure and heart rate, at 5-min intervals for 20 min. RESULTS: The two groups were well matched for age, sex, FEV1, and inhaled @entity0 dose. Baseline values for serum @entity4 , diastolic blood pressure and heart rate were not significantly different comparing @entity2 16-Gln27 vs Gly16- @entity1 27. The mean +/- SEM maximum serum @entity4 change from baseline over 20 min was significantly greater (P = 0.04) for @entity2 16-Gln27: -0.37 +/- 0.05 mmol l(-1) vs Gly16- @entity1 27: -0.23 +/- 0.04 mmol l(-1); 95% CI for difference: -0.01 to -0.28 mmol l(-1). The maximum diastolic blood pressure change from baseline over 20 min was significantly greater (P = 0.0008) for @entity2 16-Gln27: -13 +/- 1 mmHg vs Gly16- @entity1 27: -4 +/- 2 mmHg; 95% CI for difference: -5, 14 mmHg. There was no significant difference comparing the maximum heart rate change from baseline for @entity2 16-Gln27: 10 +/- 3 beats @entity5 ) vs Gly16- @entity1 27: 10 +/- 3 beats @entity5 ). CONCLUSIONS: Caucasian @entity3 subjects with the @entity2 16-Gln27 haplotype exhibited a greater systemic response to inhaled @entity8 , compared with those with the @entity9 16- @entity1 27 haplotype. The attenuated @entity6 response in the Gly16-Glu27 haplotype would be in keeping with increased susceptibility to prior down-regulation by endogenous @entity7 .

title: Acute systemic effects of inhaled @entity8 in XXXX subjects expressing common homozygous @entity6 haplotypes at positions 16 and 27.

answer: @entity3


abstract: PURPOSE: Our aim was to morphologically investigate the occurrence of fibroblasts, chondrocytes, and blood vessels in the tissue of the @entity2 ( @entity2 ) disc, the intermediate zone, and the posterior disc attachment region in control autopsy specimens and to compare the results with those observed in corresponding tissues from @entity0 with @entity2 internal derangement. @entity0 AND METHODS: First, 20 bilateral @entity2 disc specimens from selected autopsy cases were analyzed by conventional morphometry. Thus, the volume density of fibroblasts, chondrocytes, and blood vessels was determined. Second, the obtained results from the right joint of the autopsy disc specimens were compared with 12 @entity2 disc specimens obtained at surgery from @entity0 with internal derangement. RESULTS: The tissue compartments of interest (disc, intermediate zone, and posterior disc attachment region) were identified unequivocally in all specimens. None of the autopsy cases showed any significant difference between the right and @entity3 or related to gender. The only variable that differed between autopsy and @entity0 specimens was volume density of blood vessels, which was higher in @entity0 specimens. CONCLUSIONS: We found that the volume density of blood vessels was significantly higher in the posterior disc attachment region in @entity0 specimens than in autopsy controls. Whether this reflects a role for vessels in the pathogenesis of @entity2 internal derangement or merely is a reaction to another @entity1 remains to be settled. In both the autopsy control and @entity0 specimens, chondrocytes and fibroblasts were characteristic for disc respective posterior disc attachment region. Thus it appears that the occurrence of these cells can be used to distinguish @entity2 disc from posterior disc attachment in small biopsy specimens.

title: Characterization of tissue components in the XXXX disc and posterior disc attachment region: internal derangement and control autopsy specimens compared by morphometry.

answer: @entity2


abstract: A Japanese @entity0 aged 13 years with @entity13 anti-neutrophil cytoplasmic antibodies(MPO-ANCA)-associated @entity7 (GN) progressed to @entity4 after 7 years' clinical observation. She had been suffering from @entity1 flare associated with serum MPO-ANCA elevation(i.e. 153 EU/ml, 208 EU/ml and 358 EU/ml, maximum at each of the episodes, normal < 10 EU/ml). Each flare was treated successfully with @entity6 combined with @entity8 and @entity5 . However, her renal function gradually deteriorated, and peritoneal dialysis( @entity11 ) was initiated 7 years after the onset of the disease. During the clinical course, no extrarenal manifestations were observed. Due to subsidence of the serum MPO-ANCA titer(10 EU/ml) after starting @entity11 , @entity6 and @entity5 were tapered thereafter. Her daily urine volume was preserved at approximately 600 ml at that time. She suddenly developed @entity9 with severe @entity3 , @entity10 and @entity2 4 months after discontinuation of immunosuppressive therapy. The serum titer of MPO-ANCA increased to 100 EU/ml. These clinical observation suggests that disease flare may occur in selected @entity0 with MPO-ANCA-associated GN, who develop @entity4 requiring @entity11 . Although recurrent flare associated with an increased serological activity in a proportion of @entity0 with @entity12 who have received dialysis has been reported to date, to our knowledge, a similar clinical observation in the MPO-ANCA-associated GN has not been reported. Selected @entity0 with the disease should be followed with close observation after undergoing dialysis.

title: [A case of ANCA-associated XXXX without extrarenal symptoms with disease flare after starting dialysis].

answer: @entity7


abstract: BACKGROUND: Prosthetic or pericardial patches used for the closure of @entity1 are associated with infrequent but definite problems. As an alternative, we used a right atrial free-wall patch in 12 @entity0 , 7-54 years of age. METHODS AND RESULTS: The presence of a large secundum @entity1 (n=2). associated mitral @entity3 (n=7), primum @entity2 (n=1) necessitated the use of a patch. The mitral valve was repaired in 9 @entity0 (including 2 with a primum defect). One @entity0 with a primum defect who was in congestive @entity4 preoperatively died after 3 weeks due to refractory @entity5 . The remaining @entity0 were discharged 5 to 7 days post procedure. No flow was detected across the septal patch on predischarge echocardiography. One @entity0 underwent reoperation for failed mitral valve repair one month postprocedure. At reoperation, the patch was found to be intact with normal texture and without any suture dehiscence. Histopathological examination of the explanted patch revealed viable endothellum and subendothelial muscle on both surfaces of the patch. Follow-up ranged from 6 to 36 months. Echocardiography performed after 6 to 32 months post procedure showed an intact patch with no residual defect. All the @entity0 are in sinus rhythm. Holter monitoring performed in 6 @entity0 was normal in all of them. Electrophysiological study was performed in 2 @entity0 using a mapping catheter 4 and 6 months post-procedure, respectively, and recorded normal atrial potentials from the site of the patch. CONCLUSIONS: The use of an autologous free right atrial wall as a patch for @entity1 closure is a viable option.

title: Autologous right atrial patch for closure of XXXX .

answer: @entity1


abstract: AIMS: Blood transfusions are often given to surgical @entity0 . This study was designed to assess whether @entity2 ( @entity2 ) reduces exposure to allogeneic blood, affects clinical outcome and hospital stay, and is feasible in colorectal surgery. METHODS: All ASA 1 and 11 @entity0 undergoing colectomies performed between 1997 and 1999 were identified retrospectively from our @entity1 database to ascertain our current peri and postoperative transfusion practice. Twenty-six selected @entity0 subsequently underwent @entity2 during colectomy surgery. The number of @entity0 and units transfused were identified. RESULTS: One hundred and twenty-three of 317 (39%) @entity0 identified from our @entity1 database were transfused a total of 328 units (median 2, range 1-7). Of the 26 @entity0 undergoing @entity2 , 4 (15%) were transfused a total of 13 units (median 3, range 2-5). The reduction in number of @entity0 transfused was statistically significant (P=0.017). @entity2 increased anaesthetic time by a median of 19 min. There were no complications associated with @entity2 and the median hospital stay was 9 days (range 6-13). CONCLUSIONS: In this pilot study of selected @entity0 , @entity2 is a feasible and effective method of reducing allogeneic blood exposure in major colorectal surgery. A prospective randomised controlled trial is now urgently required.

title: XXXX in colorectal surgery.

answer: @entity2


abstract: @entity7 is a relatively common oral lesion that, in a varying proportion of cases, undergoes malignant transformation. The aim of this review was to assess the effectiveness of treatments for @entity8 . Randomized controlled trials (RCTs) enrolling @entity0 with a diagnosis of @entity7 were identified by searching biomedical databases, hand-searching relevant oral medicine journals, and contacting oral medicine experts through a European mailing list. The methodological quality of included studies was assessed on the basis of the method of allocation concealment, blindness of the study, and loss of @entity0 . Data were analyzed by calculating relative risk. @entity1 , demonstrated by histopathological examination, was the main outcome considered. Secondary outcomes included clinical resolution of the lesion and variation in @entity3 severity. Six RCTs were included in the review. @entity2 and @entity6 were tested in four RCTs; the other agents tested were @entity4 , mixed tea, and beta carotene. Malignant transformation was recorded in just two studies: none of the treatments tested showed a benefit when compared with placebo. Treatment with @entity5 and @entity2 or @entity6 was associated with better rates of clinical remission, compared with placebo or absence of treatment. Whenever reported, a high rate of relapse was a common finding. Side effects of variable severity were often described; however, interventions were well accepted by @entity0 since drop-out rates were similar between treatment and control groups. It is noteworthy that the possible effectiveness of surgical interventions, including laser therapy and cryotherapy, has apparently never been studied by means of an RCT. To date, in conclusion, there is no evidence of effective treatment in preventing @entity1 . Treatments may be effective in the resolution of lesion; however, relapses and adverse effects are common.

title: Systematic review of randomized trials for the treatment of XXXX .

answer: @entity7


abstract: To investigate effects by @entity6 on pancreatic A-cell secretion and intermediary metabolism, isolated pancreatic islets from normal and @entity5 treated @entity2 (A-cell rich islets) were incubated in the presence of @entity1 (5.5 mM) +/- @entity6 (10 mM). @entity4 significantly enhanced glucagon release from 297 +/- 54 to 528 +/- 53 pg/micrograms DNA/h in normal islets and from 553 +/- 31 to 806 +/- 50 pg/micrograms DNA/h in A-cell rich islets. All results were expressed on the basis of islet DNA concentration, being 66 +/- 4 ng DNA per normal islet and @entity0 ng DNA per A-cell rich islet. Simultaneously, @entity4 suppressed @entity1 oxidation to 64 per cent in normal islets and to 47 per cent of basal oxidation in A-cell rich islets. Islet content of @entity3 was also reduced by @entity4 to about 60 per cent in A-cell rich islets, but not significantly changed in normal islets. @entity4 oxidation, at 5.5 mM- @entity1 , was considerably higher in A-cell rich islets (911 +/- 65 pmol/micrograms DNA/h) than in normal islets (313 +/- 52 pmol/micrograms DNA/h). Addition of porcine insulin (25 mU/ml) counteracted these effects by @entity4 , i.e. suppressed glucagon release but increased @entity1 oxidation and @entity3 content of the A-cell rich islets. The present findings demonstrate that @entity4 stimulates glucagon release and is readily metabolized by the A-cells. Furthermore, the regulation of glucagon secretion by @entity4 appears to be reciprocally related to factors affecting @entity1 metabolism and @entity3 -levels in the A-cell.

title: Evidence for metabolic regulation of pancreatic glucagon secretion by XXXX .

answer: @entity6


abstract: @entity4 (TC) of the rotator cuff is a transient @entity1 with a high rate of spontaneous resorption of the deposit. Therefore, primary treatment should be conservative. In cases of persistent @entity2 despite conservative treatment, extracorporeal shock wave therapy (ESWT) can be performed as an alternative minimally invasive method. Various short-term studies have demonstrated the efficiency of ESWT for TC. To evaluate the short- and long-term results, complications, and the number of operations avoided by ESWT, a prospective study with 115 @entity0 was performed over a period of 4 years. The @entity0 had received high-energy ESWT once (group A: n = 56) or twice (group B: n = 59). Six months after therapy, 47% in group A and 77% in group B showed evidence of disappearance or disintegration of the @entity3 deposits. @entity2 relief was achieved in 45% of group A and 53% of group B. Four years after treatment, 20% of the @entity0 had undergone surgery on the involved shoulder. Of the remaining @entity0 , 59% (68 @entity0 ) were seen for follow-up. Subjectively, 78% of group A and 87% of group B judged the treatment to be successful. X-ray examination revealed complete or partial resorption of the @entity3 deposit in 93% in both groups. The Constant score increased from 45 before treatment to 88 in group A and 85 in group B after treatment. ESWT was successful for about 70% of the treated @entity0 with no long-term complications seen.

title: [Extracorporeal shockwave therapy (ESWT) in XXXX calcarea of the rotator cuff. Long-term results and efficacy].

answer: @entity4


abstract: AIMS: The frequency of the Taq I A alleles (A1 and A2) of the D2 @entity2 receptor ( @entity4 ) gene was examined in Caucasian @entity3 ( @entity3 ) @entity0 and controls. RESULTS: In 91 @entity3 @entity0 , the frequency of the A1 allele was higher (P = 6.12 x 10(-3)) than in the 51 controls. In the 38 @entity3 harmful drinkers (>or=60 g @entity1 /day), A1 allelic frequency was higher (P = 3.91 x 10(-2)) than in the 53 non-harmful drinkers (<60 g @entity1 /day), the former being also higher (P = 3.76 x 10(-4)) than in controls. However, there was no difference between non-harmful drinkers and controls. Based on @entity4 allelic association, the 35 @entity3 @entity0 with the A1(+) (A1A1, A1A2) allele consumed more than twice the daily amount of @entity1 than the 56 @entity0 with the A1(-) (A2A2) allele (P = 1.94 x 10(-3)). When the hourly rate of @entity1 consumed was compared, A1(+) allelic @entity0 consumed twice the rate of the A1(-) allelic @entity0 (P < 10(-7)). CONCLUSION: The @entity4 A1 allele was associated with @entity3 . However, this association was found only in the harmful drinkers. @entity3 @entity0 with the A1(+) allele consumed more @entity1 than @entity0 with the A1(-) allele. The importance of determining @entity1 consumption in @entity4 association studies with @entity3 is suggested.

title: Harmful drinking in military veterans with @entity3 : association with the D2 XXXX receptor A1 allele.

answer: @entity2


abstract: AIMS: The frequency of the Taq I A alleles (A1 and A2) of the D2 @entity2 receptor ( @entity4 ) gene was examined in Caucasian @entity3 ( @entity3 ) @entity0 and controls. RESULTS: In 91 @entity3 @entity0 , the frequency of the A1 allele was higher (P = 6.12 x 10(-3)) than in the 51 controls. In the 38 @entity3 harmful drinkers (>or=60 g @entity1 /day), A1 allelic frequency was higher (P = 3.91 x 10(-2)) than in the 53 non-harmful drinkers (<60 g @entity1 /day), the former being also higher (P = 3.76 x 10(-4)) than in controls. However, there was no difference between non-harmful drinkers and controls. Based on @entity4 allelic association, the 35 @entity3 @entity0 with the A1(+) (A1A1, A1A2) allele consumed more than twice the daily amount of @entity1 than the 56 @entity0 with the A1(-) (A2A2) allele (P = 1.94 x 10(-3)). When the hourly rate of @entity1 consumed was compared, A1(+) allelic @entity0 consumed twice the rate of the A1(-) allelic @entity0 (P < 10(-7)). CONCLUSION: The @entity4 A1 allele was associated with @entity3 . However, this association was found only in the harmful drinkers. @entity3 @entity0 with the A1(+) allele consumed more @entity1 than @entity0 with the A1(-) allele. The importance of determining @entity1 consumption in @entity4 association studies with @entity3 is suggested.

title: Harmful drinking in military veterans with XXXX : association with the D2 @entity2 receptor A1 allele.

answer: @entity3


abstract: Within the Italian CNR Biomedical Technology programmes a large multicentre clinical trial on @entity5 -expressing @entity4 has been carried out. F(ab')2 fragments of anti- @entity5 monoclonal antibody (MAb) FO23C5, radiolabelled with either 131I or 111In, were supplied to 10 different Italian nuclear medicine departments. Over 500 @entity1 with @entity0 have been investigated. The results obtained in our nuclear medicine department are reported here. In @entity3 group, the 131I compound showed better results except in liver metastases detected only in 28/57 @entity1 . In the @entity2 group, very satisfactory results were achieved in primary @entity3 and local or systemic recurrences: 111In tracer was preferentially used. In the @entity0 group immunoscintigraphy proved to be helpful in differential diagnosis of @entity3 . Significant improvements of diagnostic sensitivity were achieved in @entity3 @entity1 by means of i.p. administration. Finally, 12 @entity1 with advanced disease were given different 131I radioiodinated MAbs (100 mCi average dose). Administration route was either i.v. (3 cases) or i.p. (9 cases). Clinical and instrumental evidence of complete (1) or partial (7) response was observed in 8 @entity1 .

title: Antibody-guided diagnosis: an Italian experience on XXXX -expressing @entity3 .

answer: @entity5


abstract: Within the Italian CNR Biomedical Technology programmes a large multicentre clinical trial on @entity5 -expressing @entity4 has been carried out. F(ab')2 fragments of anti- @entity5 monoclonal antibody (MAb) FO23C5, radiolabelled with either 131I or 111In, were supplied to 10 different Italian nuclear medicine departments. Over 500 @entity1 with @entity0 have been investigated. The results obtained in our nuclear medicine department are reported here. In @entity3 group, the 131I compound showed better results except in liver metastases detected only in 28/57 @entity1 . In the @entity2 group, very satisfactory results were achieved in primary @entity3 and local or systemic recurrences: 111In tracer was preferentially used. In the @entity0 group immunoscintigraphy proved to be helpful in differential diagnosis of @entity3 . Significant improvements of diagnostic sensitivity were achieved in @entity3 @entity1 by means of i.p. administration. Finally, 12 @entity1 with advanced disease were given different 131I radioiodinated MAbs (100 mCi average dose). Administration route was either i.v. (3 cases) or i.p. (9 cases). Clinical and instrumental evidence of complete (1) or partial (7) response was observed in 8 @entity1 .

title: Antibody-guided diagnosis: an Italian experience on @entity5 -expressing XXXX .

answer: @entity3


abstract: Established treatments for @entity7 act ei-ther on hyperproliferation, @entity0 , aberrant epidermal differentiation or a combination of these aspects of the disease. Potential new drugs for treatment of @entity7 or other @entity1 in epidermal differentiation can be identified by high-throughput screening of large compound libraries using surrogate markers for the disease. Here we describe a screening model to detect pharmacologically active drugs in two keratinocyte-based, 96-well culture models that use expression of @entity12 ( @entity12 ) and @entity13 ( @entity13 )/elafin as markers for normal and psoriatic differentiation, respectively, and allow multiple parameters to be determined from a single well. In this model we tested a number of compounds in a pharmacological range from 10(-7) to 10(-5) M, including known antipsoriatic drugs, and experimental drugs that are potentially useful in the treatment of @entity7 . @entity8 , @entity11 and the @entity4 mitogen-activated protein (MAP) kinase inhibitor @entity15 displayed a strong inhibitory effect on @entity13 expression while @entity2 , @entity3 , the @entity10 derivative @entity9 and the @entity4 MAP kinase inhibitor @entity5 showed only moderate inhibition. @entity6 and @entity14 did not affect the expression of @entity13 . With respect to @entity12 expression, @entity8 , @entity9 , @entity5 and @entity15 exhibited strong inhibition while @entity11 showed only moderate suppression of this normal differentiation marker. Expression levels of @entity12 were not significantly affected by @entity3 , @entity6 , @entity2 or @entity14 . This model system parallels most, but not all, findings on the in vitro effect of known antipsoriatic drugs on keratinocytes. In addition, the model identifies @entity4 MAP kinase inhibitors as potent suppressors of differentiation-associated gene expression. Although further delineation and validation of this model is required, we conclude that the system is amenable to down-scaling and application as a high-throughput screen for differentiation-modifying compounds.

title: A simple technique for high-throughput screening of drugs that modulate normal and XXXX -like differentiation in cultured human keratinocytes.

answer: @entity7


abstract: Deformities of the lower extremities are often a combination of angular and rotational components. The rotational component of @entity1 may be difficult to measure using plain radiography. Based on the current study, the computed tomography rotational malalignment test was developed. Evaluation of lower extremity alignment was done on 56 @entity0 . Rotational malalignment was diagnosed in 14 limbs of nine @entity0 . In all @entity0 , correction of angular and @entity4 was done simultaneously using an Ilizarov external fixator. The frame included a standard angular distraction system and a derotation block interconnected via an additional empty ring. In all cases, successful correction of angular and @entity4 was achieved. The @entity2 was eliminated in all seven @entity0 having preexisting chronic @entity2 . There were no cases of @entity3 or nonunion. This simple and reliable method allowed precise analysis of the deformity in the transverse plane. Preoperative frame construction incorporating the derotational module decreased the time of the operation and allowed one-stage correction of rotational and @entity1 without additional manipulations.

title: Correction of combined angular and XXXX by the Ilizarov method.

answer: @entity4


abstract: We report the clinicopathologic features of 24 uterine primary and metastatic @entity13 with fibromyxoid features (ESS-F) and smooth muscle differentiation (ESS-SM) ( @entity13 variants). Two groups of @entity4 were retrieved from the surgical pathology files at Memorial Sloan-Kettering Cancer Center: 1) gynecologic mesenchymal neoplasms with striking smooth muscle or fibroblastic differentiation that did not meet the clinical or histologic criteria for @entity7 or other established neoplasms containing smooth muscle; and 2) metastatic lesions showing ovoid and spindle cell morphology, involving lung, originally diagnosed as @entity6 , low-grade smooth @entity14 , @entity15 , @entity11 , and benign metastasizing @entity10 . We identified 12 @entity0 with 30 @entity4 ; 24 were available for review. The mean age was 51 years (range 21-74 years). Follow-up >1 year was available for eight @entity0 , with a mean time of 8.5 years. Each @entity0 had a uterine primary and 10 experienced @entity2 . Mean time to recurrence was 6.8 years. Sites of @entity2 included lung, retroperitoneum, right atrium/inferior vena cava, colon, and ovaries. No @entity0 died of disease, but in many cases the follow-up period ended with the discovery of a @entity2 . Four @entity0 were originally diagnosed with @entity13 , but other presenting diagnoses included benign metastasizing @entity10 , @entity1 , smooth @entity14 of uncertain or low malignant potential, and @entity12 . On review each @entity0 had at least one @entity4 (primary and/or @entity2 ) that was determined to be an @entity13 variant. Review diagnoses were as follows: @entity13 (nonvariant), ESS-F, and ESS-SM. Eight of 10 @entity4 with available slides were endometrial stomal @entity5 variants (six ESS-F and two ESS-SM). When these variant features were present, they comprised between 50% and 100% of the @entity4 . The variant histology @entity4 exhibited prominent spiral arterioles, perivascular @entity3 , and stromal cell condensation around blood vessels. All @entity2 but one were @entity4 ; eight were ESS-F and five were ESS-SM. Four @entity2 did not resemble the uterine primary. @entity9 marked smooth muscle mostly but not specifically. h-Caldesmon marked smooth muscle exclusively. Endometrial stromal cells as well as some fibroblasts and smooth muscle cells expressed @entity8 . We conclude that the presence of even focal endometrial stromal differentiation in an invasive uterine mesenchymal lesion with a predominant low-grade smooth muscle, fibroblastic, and/or myxoid phenotype should permit classification as low-grade @entity5 -they should be considered @entity13 .

title: @entity13 with unusual histologic features: a report of 24 primary and XXXX emphasizing fibroblastic and smooth muscle differentiation.

answer: @entity2


abstract: We report the clinicopathologic features of 24 uterine primary and metastatic @entity13 with fibromyxoid features (ESS-F) and smooth muscle differentiation (ESS-SM) ( @entity13 variants). Two groups of @entity4 were retrieved from the surgical pathology files at Memorial Sloan-Kettering Cancer Center: 1) gynecologic mesenchymal neoplasms with striking smooth muscle or fibroblastic differentiation that did not meet the clinical or histologic criteria for @entity7 or other established neoplasms containing smooth muscle; and 2) metastatic lesions showing ovoid and spindle cell morphology, involving lung, originally diagnosed as @entity6 , low-grade smooth @entity14 , @entity15 , @entity11 , and benign metastasizing @entity10 . We identified 12 @entity0 with 30 @entity4 ; 24 were available for review. The mean age was 51 years (range 21-74 years). Follow-up >1 year was available for eight @entity0 , with a mean time of 8.5 years. Each @entity0 had a uterine primary and 10 experienced @entity2 . Mean time to recurrence was 6.8 years. Sites of @entity2 included lung, retroperitoneum, right atrium/inferior vena cava, colon, and ovaries. No @entity0 died of disease, but in many cases the follow-up period ended with the discovery of a @entity2 . Four @entity0 were originally diagnosed with @entity13 , but other presenting diagnoses included benign metastasizing @entity10 , @entity1 , smooth @entity14 of uncertain or low malignant potential, and @entity12 . On review each @entity0 had at least one @entity4 (primary and/or @entity2 ) that was determined to be an @entity13 variant. Review diagnoses were as follows: @entity13 (nonvariant), ESS-F, and ESS-SM. Eight of 10 @entity4 with available slides were endometrial stomal @entity5 variants (six ESS-F and two ESS-SM). When these variant features were present, they comprised between 50% and 100% of the @entity4 . The variant histology @entity4 exhibited prominent spiral arterioles, perivascular @entity3 , and stromal cell condensation around blood vessels. All @entity2 but one were @entity4 ; eight were ESS-F and five were ESS-SM. Four @entity2 did not resemble the uterine primary. @entity9 marked smooth muscle mostly but not specifically. h-Caldesmon marked smooth muscle exclusively. Endometrial stromal cells as well as some fibroblasts and smooth muscle cells expressed @entity8 . We conclude that the presence of even focal endometrial stromal differentiation in an invasive uterine mesenchymal lesion with a predominant low-grade smooth muscle, fibroblastic, and/or myxoid phenotype should permit classification as low-grade @entity5 -they should be considered @entity13 .

title: XXXX with unusual histologic features: a report of 24 primary and @entity2 emphasizing fibroblastic and smooth muscle differentiation.

answer: @entity13


abstract: Rare reports describe high molecular weight cytokeratin (clone 34betaE12) antibody cross-reactivity in scattered @entity2 ( @entity2 ) cells, yet most often not in a true basal cell distribution. There are no data specifically describing 34betaE12 reactivity in basal cells in @entity2 . From August 10, 1995 to May 1, 2000, a total of 3198 consult prostate needle biopsies with @entity2 and a 34betaE12 immunoperoxidase stain were reviewed at our institution. Thirty-six cases (1.1%), which on @entity3 and @entity4 stain were unequivocal @entity1 , had at least focal 34betaE12 positivity in a basal cell distribution. Twenty-five had original diagnostic slides for review. All @entity1 were Gleason score 6. The mean number of @entity1 glands per case was 36.9 (10-108) with an average of 39% of glands (1-100%) showing 34betaE12 reactivity. Twenty-one cases had patchy staining in a basal cell distribution with one other case showing continuous staining. An additional case showed mainly @entity1 cell reactivity with rare basal cell staining. The final two cases showed a zonal staining pattern with small glands toward one side of the lesion showing basal cells [one with @entity6 ( @entity6 ); one without @entity6 ]. @entity6 was present in 16 of 25 (64%) cases adjacent to @entity2 . The mean number of @entity6 glands was 1.36 (1-6). In cases with @entity6 the mean ratio of @entity2 was 6.8 (0.5-13.0). In 12 cases in which the lesion was still present on deeper sectioning, we were able to confirm in nine cases the presence of basal cells using antibodies to @entity5 , another marker for prostatic basal cells. Four of the 25 @entity0 underwent radical prostatectomy; all showed Gleason score 6 @entity2 . Three radical prostatectomies demonstrated 34betaE12 reactivity: two with patchy staining in a basal cell distribution and one with mainly @entity1 cell staining. Adjacent @entity6 was present in all three radical prostatectomy specimens. Rare lesions with the appearance of @entity2 show 34betaE12 staining in a basal cell distribution either from retention of basal cells by early invasive @entity1 or from @entity6 outpouching. The lack of adjacent @entity6 in some cases and the large ratio of small atypical glands to @entity6 glands argue against @entity6 outpouching as the sole explanation. In cases with adjacent @entity6 a comparison of the proximity and number of the small, atypical, infiltrative appearing glands to @entity6 is helpful. The diagnosis of @entity2 in the face of positive 34betaE12 basal cell staining should be made with extreme caution, only in the face of unequivocal @entity1 on the @entity3 and @entity4 stain.

title: Can basal cells be seen in XXXX ?: an immunohistochemical study using high molecular weight cytokeratin (clone 34betaE12) antibody.

answer: @entity2


abstract: OBJECTIVE: For clarification of the direct relationship between the reactivation of herpes simplex virus and the development of @entity3 , a detection of the virus genome by @entity1 diagnostics and a quantitative analysis of its time-course change are both needed. The authors detected the HSV genome in specimens from @entity0 with @entity3 , quantified its number of copies, and examined time-course changes. SUBJECTS AND METHODS: The subjects were 16 @entity0 with @entity3 . The tear fluid and saliva from the submandibular gland and the parotid gland were separately collected from the affected and unaffected sides twice or more. A total of 244 specimens were subjected to extraction of @entity1 , polymerase chain reaction, and microplate hybridization. RESULTS: @entity2 @entity1 was detected in 38 specimens (11.8%) from 5 @entity0 (31%). The high detection (28.5%) was obtained within 2 weeks after onset. Detection at 3 weeks and later (2.8%) was significantly lower ( < 0.05). In three cases, @entity1 was also found on the unaffected side in the initial phase of the disease, but detection on that side (18.9%) was significantly lower than on the affected side (83.8%) ( < 0.01). The number of copies of the @entity2 genome was large on the affected side and early after the onset of the disease. CONCLUSIONS: The reactivation of @entity2 on the affected side is involved as a pathogenic factor of @entity3 . A reactivation of @entity2 may be generated even on the unaffected side in the early phase of the disease. Herpes simplex virus @entity1 was not detected in any of the examined specimens collected from the remaining 11 cases. The need for constant study to clarify other causative factors of @entity3 remains.

title: Secretion and dynamics of herpes simplex virus in tears and saliva of @entity0 with XXXX .

answer: @entity3


abstract: OBJECTIVE: For clarification of the direct relationship between the reactivation of herpes simplex virus and the development of @entity3 , a detection of the virus genome by @entity1 diagnostics and a quantitative analysis of its time-course change are both needed. The authors detected the HSV genome in specimens from @entity0 with @entity3 , quantified its number of copies, and examined time-course changes. SUBJECTS AND METHODS: The subjects were 16 @entity0 with @entity3 . The tear fluid and saliva from the submandibular gland and the parotid gland were separately collected from the affected and unaffected sides twice or more. A total of 244 specimens were subjected to extraction of @entity1 , polymerase chain reaction, and microplate hybridization. RESULTS: @entity2 @entity1 was detected in 38 specimens (11.8%) from 5 @entity0 (31%). The high detection (28.5%) was obtained within 2 weeks after onset. Detection at 3 weeks and later (2.8%) was significantly lower ( < 0.05). In three cases, @entity1 was also found on the unaffected side in the initial phase of the disease, but detection on that side (18.9%) was significantly lower than on the affected side (83.8%) ( < 0.01). The number of copies of the @entity2 genome was large on the affected side and early after the onset of the disease. CONCLUSIONS: The reactivation of @entity2 on the affected side is involved as a pathogenic factor of @entity3 . A reactivation of @entity2 may be generated even on the unaffected side in the early phase of the disease. Herpes simplex virus @entity1 was not detected in any of the examined specimens collected from the remaining 11 cases. The need for constant study to clarify other causative factors of @entity3 remains.

title: Secretion and dynamics of herpes simplex virus in tears and saliva of XXXX with @entity3 .

answer: @entity0


abstract: OBJECTIVE: The role of iliac artery angioplasty and stenting (IAS) for the treatment of limb-threatening @entity1 is not defined. IAS has been used primarily for @entity0 with disabling @entity5 . Because poorer results have been shown in @entity0 with critical @entity1 after iliac artery angioplasty, the purpose of this study was to estimate the influence of risk factors on the outcome of iliac angioplasty and stent placement in @entity0 with limb-threatening @entity1 . METHODS: During a 5-year period (from 1996 to 2001), 85 iliac angioplasty and stent placement procedures (107 stents) were performed in 31 @entity0 and 43 @entity0 with limb-threatening @entity1 . @entity0 with @entity5 were specifically excluded. The criteria prepared by the Ad Hoc Committee on Reporting Standards (Society for Vascular Surgery/International Society for Cardiovascular Surgery) were followed to define the variables. The TransAtlantic InterSociety Consensus classification was used to characterize the type of @entity2 . Both univariate (Kaplan-Meier [KM]) and multivariate analyses (Cox proportional hazards model) were used to determine the association between variables, cumulative patency, limb salvage, and survival. RESULTS: Indications for iliac angioplasty with stenting were @entity3 (56%) and tissue loss (44%). Primary stenting was performed in 36 @entity0 (42%). Stents were placed selectively after iliac angioplasty mainly for residual stenosis or pressure gradient (43%). Overall, primary stent patency rate was 90% at 1 year, 74% at 3 years, and 69% at 5 years. Primary stent patency rate was significantly reduced in @entity0 compared with @entity0 (KM, log-rank test, P <.001). Primary patency rates at 1, 3, and 5 years were 79%, 57%, and 38% for @entity0 and 92%, 88%, and 88% for @entity0 . Primary stent patency rate also was significantly reduced in @entity0 with @entity4 ( @entity6 level, >1.6 mg/dL; KM, log-rank test, P <.001). Cox regression analysis identified female gender (relative risk, 5.1; 95% CI, 1.8 to 7.9; P =.002) and @entity4 (relative risk, 6.6; 95% CI, 1.6 to 14.2; P =.01) as independent predictors of decreased primary stent patency. No independent predictors for limb salvage and survival were identified. CONCLUSION: @entity0 undergoing iliac angioplasty and stenting for limb-threatening @entity1 have significantly reduced primary stent patency rates and may need additional procedures to obtain satisfactory clinical improvement and limb salvage. @entity0 with @entity4 and critical @entity1 also have reduced primary stent patency rates after IAS. Limb salvage, as shown in this study, is not affected by previous iliac stent failure.

title: Predictors for adverse outcome after iliac angioplasty and stenting for limb-threatening XXXX .

answer: @entity1


abstract: BACKGROUND: Induced @entity3 (suspended animation) could provide valuable time to repair major @entity4 if safely induced in @entity0 with @entity1 . We report a novel method of doing this in a @entity5 model of uncontrolled lethal @entity2 (ULH) that resulted in preservation of learning ability and memory. METHODS: Yorkshire @entity5 (100 to 125 lb) underwent ULH before rapid intra-aortic infusion of a hypothermic (4 degrees C), @entity7 (70 mEq/L) organ preservation solution by a left thoracotomy. Cooling continued until core temperature reached 10 degrees C, and this was maintained for 60 minutes using low-flow cardiopulmonary bypass. @entity4 were repaired during this state of suspended animation, which was then reversed, and the animals were observed for 6 weeks. Cognitive functions were tested by training animals to retrieve food from color-coded boxes. Postoperatively, the ability to remember this task and a 75-point objective neurologic scale were used to test neurologic function. In experiment I, ULH was caused by lacerating thoracic aorta (n = 9). Five preoperatively untrained animals were trained to perform the task and compared with control animals (n = 15), and 4 preoperatively trained animals were tested for memory retention postoperatively. In experiment II, ULH was induced by creating an iliac artery and @entity1 (n = 15). Animals were kept in shock for 15, 30, and 60 minutes before the induction of @entity6 . RESULTS: In experiment I, surviving animals (7/9) were neurologically intact, and their capacity to learn new skills was no different than for control animals. All pretrained animals demonstrated complete memory retention. In experiment II, survival with 15, 30, and 60 minutes of shock were 80%, 60%, and 80%, respectively. All animals (except 1) in the 60-minute group were neurologically intact and displayed normal learning capacity. CONCLUSIONS: Induction of hypothermic @entity3 (by thoracotomy) for repair of complex @entity1 is feasible with preservation of normal neurologic function, even after extended periods of shock from an intra-abdominal source of uncontrolled @entity2 .

title: Learning and memory is preserved after induced asanguineous XXXX in a @entity5 model of traumatic exsanguination.

answer: @entity3


abstract: BACKGROUND: Induced @entity3 (suspended animation) could provide valuable time to repair major @entity4 if safely induced in @entity0 with @entity1 . We report a novel method of doing this in a @entity5 model of uncontrolled lethal @entity2 (ULH) that resulted in preservation of learning ability and memory. METHODS: Yorkshire @entity5 (100 to 125 lb) underwent ULH before rapid intra-aortic infusion of a hypothermic (4 degrees C), @entity7 (70 mEq/L) organ preservation solution by a left thoracotomy. Cooling continued until core temperature reached 10 degrees C, and this was maintained for 60 minutes using low-flow cardiopulmonary bypass. @entity4 were repaired during this state of suspended animation, which was then reversed, and the animals were observed for 6 weeks. Cognitive functions were tested by training animals to retrieve food from color-coded boxes. Postoperatively, the ability to remember this task and a 75-point objective neurologic scale were used to test neurologic function. In experiment I, ULH was caused by lacerating thoracic aorta (n = 9). Five preoperatively untrained animals were trained to perform the task and compared with control animals (n = 15), and 4 preoperatively trained animals were tested for memory retention postoperatively. In experiment II, ULH was induced by creating an iliac artery and @entity1 (n = 15). Animals were kept in shock for 15, 30, and 60 minutes before the induction of @entity6 . RESULTS: In experiment I, surviving animals (7/9) were neurologically intact, and their capacity to learn new skills was no different than for control animals. All pretrained animals demonstrated complete memory retention. In experiment II, survival with 15, 30, and 60 minutes of shock were 80%, 60%, and 80%, respectively. All animals (except 1) in the 60-minute group were neurologically intact and displayed normal learning capacity. CONCLUSIONS: Induction of hypothermic @entity3 (by thoracotomy) for repair of complex @entity1 is feasible with preservation of normal neurologic function, even after extended periods of shock from an intra-abdominal source of uncontrolled @entity2 .

title: Learning and memory is preserved after induced asanguineous @entity3 in a XXXX model of traumatic exsanguination.

answer: @entity5


abstract: OBJECTIVE: To investigate the initial energy level required for electrical cardioversion of @entity1 ( @entity1 ). METHODS: We studied @entity0 undergoing electrical cardioversion in the 1st Multicenter Trial of SOCESP. @entity0 were divided into 2 groups according to the initial energy level of electrical cardioversion: 100J and >/=150J. We compared the efficacy of the initial and final shock of the procedure, the number of shocks administered, and the cumulative energy levels. RESULTS: Eight-six @entity0 underwent electrical cardioversion. In 53 @entity0 (62%), cardioversion was started with 100J, and in 33 @entity0 (38%), cardioversion was started with >/=150J. Groups did not differ regarding clinical features and therapeutical interventions. A tendency existed towards greater efficacy of the @entity2 in @entity0 who received >/=150J (61% vs. 42% in the 100J group, p=0.08). The number of shocks was smaller in the >/=150J group (1.5+/-0.7 vs. 2.1+/-1.3, p=0.04). No difference existed regarding the final efficacy of electrical cardioversion and total cumulative energy levels in both groups. In the subgroup of @entity0 with recent-onset @entity1 (</=48h), the cumulative energy level was lower in the 100J group (240+/-227J vs. 324+/-225J, p=0.03). CONCLUSION: @entity0 who were given initial energy of >/=150J received fewer counter shocks with a tendency toward greater success than those @entity0 who were given 100J; however, in @entity0 with recent-onset @entity1 , the average cumulative energy level was lower in the 100J group. These data suggest that electrical cardioversion should be initiated with energy levels >/=150J in @entity0 with chronic @entity1 .

title: Initial energy for external electrical cardioversion of XXXX .

answer: @entity1


abstract: BACKGROUND: @entity1 has been used for over 20 years as an antiandrogen in the treatment of @entity4 and @entity3 . No long-term studies of the safety of @entity1 used in this manner have been published. We present a study of the long-term safety and tolerance of @entity1 in 91 @entity0 with @entity4 who were followed for up to 8 years. METHODS: A survey questionnaire was sent to 210 @entity0 , and a comparison chart review of all @entity0 to whom the survey was sent was made. RESULTS: Ninety-one completed surveys were analyzed, comprising 506 @entity0 -years of followup and 200 @entity0 -years of @entity1 exposure. Mean treatment length was 28.5 months (range = 0.5-122 months). During the 8-year followup period, there were no cases of serious illness attributable to @entity1 use. Side effects were present in 59% and resulted in cessation of the drug in 15%. Diuretic effect and @entity2 were the most common adverse effects. CONCLUSIONS: After 200 @entity0 -years of exposure to @entity1 and 506 @entity0 -years of followup over 8 years, no serious illnesses thought to be attributed to @entity1 were reported. The long-term use of @entity1 in the treatment of @entity4 in @entity0 appears to be safe. Side effects, however, are common, although not usually a cause for stopping the drug.

title: Long-term safety of XXXX in @entity4 : results of an 8-year followup study.

answer: @entity1


abstract: BACKGROUND: @entity1 has been used for over 20 years as an antiandrogen in the treatment of @entity4 and @entity3 . No long-term studies of the safety of @entity1 used in this manner have been published. We present a study of the long-term safety and tolerance of @entity1 in 91 @entity0 with @entity4 who were followed for up to 8 years. METHODS: A survey questionnaire was sent to 210 @entity0 , and a comparison chart review of all @entity0 to whom the survey was sent was made. RESULTS: Ninety-one completed surveys were analyzed, comprising 506 @entity0 -years of followup and 200 @entity0 -years of @entity1 exposure. Mean treatment length was 28.5 months (range = 0.5-122 months). During the 8-year followup period, there were no cases of serious illness attributable to @entity1 use. Side effects were present in 59% and resulted in cessation of the drug in 15%. Diuretic effect and @entity2 were the most common adverse effects. CONCLUSIONS: After 200 @entity0 -years of exposure to @entity1 and 506 @entity0 -years of followup over 8 years, no serious illnesses thought to be attributed to @entity1 were reported. The long-term use of @entity1 in the treatment of @entity4 in @entity0 appears to be safe. Side effects, however, are common, although not usually a cause for stopping the drug.

title: Long-term safety of @entity1 in XXXX : results of an 8-year followup study.

answer: @entity4


abstract: Tissue weights and immunoreactive (IR) content and concentration of @entity4 , @entity2 , and vasopressin were assayed for senescent change in anterior pituitary, neurointermediate pituitary, @entity1 , hippocampus, striatum, dorsolateral cortex, and pons-medulla, as well as residual brain samples remaining after the other dissections. Groups of naive male C57BL/6J @entity0 , 8-12 months old and 28-32 months old, served as subjects. Old @entity0 exhibited significant decline in anterior pituitary and hippocampus weight. Significant increases with age were found in pons-medulla weight. @entity3 -endorphin content decreased in @entity1 and neurointermediate pituitary. IR @entity2 decreased in striatum and dorsolateral cortex. IR vasopressin content increased in @entity1 and residual brain. Assays were replicated in later experiments using additional subjects, for total Ns of up to 54 @entity0 . Although significant overall results were always consistent in direction from replication to replication, the magnitude of age change exhibited considerable variability. Such results suggest that single experiments on age changes in neuropeptides, particularly those giving negative results, should be carefully scrutinized and replicated before their acceptance as evidence for a transmitter's stability or instability throughout the lifespan.

title: Senescent change in tissue weight and immunoreactive XXXX , @entity2 , and vasopressin in eight regions of C57BL/6J @entity0 brain and pituitary.

answer: @entity4


abstract: Tissue weights and immunoreactive (IR) content and concentration of @entity4 , @entity2 , and vasopressin were assayed for senescent change in anterior pituitary, neurointermediate pituitary, @entity1 , hippocampus, striatum, dorsolateral cortex, and pons-medulla, as well as residual brain samples remaining after the other dissections. Groups of naive male C57BL/6J @entity0 , 8-12 months old and 28-32 months old, served as subjects. Old @entity0 exhibited significant decline in anterior pituitary and hippocampus weight. Significant increases with age were found in pons-medulla weight. @entity3 -endorphin content decreased in @entity1 and neurointermediate pituitary. IR @entity2 decreased in striatum and dorsolateral cortex. IR vasopressin content increased in @entity1 and residual brain. Assays were replicated in later experiments using additional subjects, for total Ns of up to 54 @entity0 . Although significant overall results were always consistent in direction from replication to replication, the magnitude of age change exhibited considerable variability. Such results suggest that single experiments on age changes in neuropeptides, particularly those giving negative results, should be carefully scrutinized and replicated before their acceptance as evidence for a transmitter's stability or instability throughout the lifespan.

title: Senescent change in tissue weight and immunoreactive @entity4 , XXXX , and vasopressin in eight regions of C57BL/6J @entity0 brain and pituitary.

answer: @entity2


abstract: Tissue weights and immunoreactive (IR) content and concentration of @entity4 , @entity2 , and vasopressin were assayed for senescent change in anterior pituitary, neurointermediate pituitary, @entity1 , hippocampus, striatum, dorsolateral cortex, and pons-medulla, as well as residual brain samples remaining after the other dissections. Groups of naive male C57BL/6J @entity0 , 8-12 months old and 28-32 months old, served as subjects. Old @entity0 exhibited significant decline in anterior pituitary and hippocampus weight. Significant increases with age were found in pons-medulla weight. @entity3 -endorphin content decreased in @entity1 and neurointermediate pituitary. IR @entity2 decreased in striatum and dorsolateral cortex. IR vasopressin content increased in @entity1 and residual brain. Assays were replicated in later experiments using additional subjects, for total Ns of up to 54 @entity0 . Although significant overall results were always consistent in direction from replication to replication, the magnitude of age change exhibited considerable variability. Such results suggest that single experiments on age changes in neuropeptides, particularly those giving negative results, should be carefully scrutinized and replicated before their acceptance as evidence for a transmitter's stability or instability throughout the lifespan.

title: Senescent change in tissue weight and immunoreactive @entity4 , @entity2 , and vasopressin in eight regions of C57BL/6J XXXX brain and pituitary.

answer: @entity0


abstract: It is believed that sexual activity increases the need to sleep in many species. However, the relationship between copulatory activity and sleep has been poorly studied. Several studies have observed variations in the sleep of female @entity2 and @entity0 as a function of their reproductive state. These effects have been correlated with the effects of female @entity3 hormones, but not with sexual activity. The aim of the present study was to evaluate the sleep-wake pattern of male @entity2 immediately after different conditions of copulatory activity. Sexually experienced male @entity2 were chronically implanted with a standard set of electrodes for sleep recording. After a control sleep recording of 8 h, the males were randomly assigned to one of the following experimental conditions: 30 min in the presence of an ovariectomized (OVX) @entity2 ; 30 min in the presence of an intact non-receptive female (NRF); with a receptive female until reaching one ejaculation (1E); and with a receptive female until reaching three ejaculations (3E). In addition, after 10 days, males were randomly exposed to one of the following copulatory conditions during 4 h: to remain in the presence of an OVX @entity2 ; to remain in the presence of an NRF female, and with receptive females until reaching sexual satiety (SS). Male sexual behavior was assessed just after the onset of the dark period, and sleep recordings were obtained during 8 h immediately after experimental testing. Both the three ejaculations group (3E) in the first experiment and the sexual satiety group (SS) in the second experiment showed enhanced percentages of time spent in @entity1 ( @entity1 ) II and a shorter latency to the first @entity1 II episode than in the control group or under basal conditions. In addition, neither the presence of a non-receptive female or an OVX female, nor sexual behavior until reaching one ejaculation induced any effect on the sleep stages. These findings suggest that the increase in @entity1 II induced by both 3E and SS may be governed by some specific mechanism that is essentially independent of physical exercise or stress. Copulatory activity might be the source of neurohormonal processes that induce sleep and may involve the participation of @entity5 , @entity4 or other endogenous regulators of sleep and wakefulness. Nevertheless, the precise mechanism by which the sexual behavior increases @entity1 is still to be determined.

title: Copulatory activity increases slow-wave sleep in the male XXXX .

answer: @entity2


abstract: @entity6 is an independent @entity1 factor. There are several factors including aging that contribute to the development of @entity6 . Nevertheless, the exact mechanisms causing this condition are still debated. We hypothesize that the age-related decrease in @entity5 levels may be consequential in @entity6 . Recently, we found that plasma @entity2 (Hcy) levels are increased in pinealectomized (PINX) @entity0 and @entity5 reverses this increase. The aim of the present study was to determine if there is a circadian rhythm of plasma Hcy in @entity0 and to examine the effect of pinealectomy on this cycle. Plasma Hcy levels demonstrated a 24-hr rhythm with a peak at 02:00 hr and a nadir at 14:00 hr in both control and PINX @entity0 . Pinealectomy did not change the phase of the rhythm or the nocturnal elevation of plasma Hcy, but it did significantly increase mean plasma Hcy levels compared with those in controls and in @entity0 that were sham pinealectomized (sPINX) (P < 0.05). @entity5 decreases plasma Hcy levels while causing an increase in total @entity3 (tGSH). In conclusion, we speculate that decreasing levels of @entity5 during aging lead to @entity6 and a decrease in t @entity4 and the latter may be one of the factors causing @entity6 in the elderly population.

title: Effects of pinealectomy on the levels and the circadian rhythm of plasma XXXX in @entity0 .

answer: @entity2


abstract: @entity6 is an independent @entity1 factor. There are several factors including aging that contribute to the development of @entity6 . Nevertheless, the exact mechanisms causing this condition are still debated. We hypothesize that the age-related decrease in @entity5 levels may be consequential in @entity6 . Recently, we found that plasma @entity2 (Hcy) levels are increased in pinealectomized (PINX) @entity0 and @entity5 reverses this increase. The aim of the present study was to determine if there is a circadian rhythm of plasma Hcy in @entity0 and to examine the effect of pinealectomy on this cycle. Plasma Hcy levels demonstrated a 24-hr rhythm with a peak at 02:00 hr and a nadir at 14:00 hr in both control and PINX @entity0 . Pinealectomy did not change the phase of the rhythm or the nocturnal elevation of plasma Hcy, but it did significantly increase mean plasma Hcy levels compared with those in controls and in @entity0 that were sham pinealectomized (sPINX) (P < 0.05). @entity5 decreases plasma Hcy levels while causing an increase in total @entity3 (tGSH). In conclusion, we speculate that decreasing levels of @entity5 during aging lead to @entity6 and a decrease in t @entity4 and the latter may be one of the factors causing @entity6 in the elderly population.

title: Effects of pinealectomy on the levels and the circadian rhythm of plasma @entity2 in XXXX .

answer: @entity0


abstract: Alterations of cell cycle-regulated genes play an important role in the process of @entity2 , and some of them are thought to be prognostic factors in @entity3 . The expressions of @entity4 , @entity5 , @entity6 and @entity7 proteins were evaluated immunohistochemically in 144 @entity0 who underwent curative esophagectomy without any adjuvant therapy before surgery. @entity4 overexpression was observed in 99 (69%) out of the 144 @entity0 . No significant correlation was noted between @entity4 and any other gene expression. @entity5 expression was observed in 12 (8.3%) out of all cases. A negative correlation was recognized between @entity5 and @entity7 expression (P=0.0004). @entity6 expression was observed in 130 (90.3%) out of all cases, whereas @entity6 expression was not observed in 11 out of the 12 @entity0 with @entity5 -positive @entity1 . A negative correlation was also found between @entity5 and @entity6 (P < 0.0001). A positive correlation was noted between @entity6 and @entity7 expression (P=0.0009). The cumulative survival rate of @entity0 without @entity6 expression was significantly lower than that of @entity0 with positive expression (P=0.003). In the multivariate survival analysis, @entity6 expression was an independent prognostic factor. In 98% of all @entity0 with @entity3 , impairment of the G1 checkpoint is due to a loss of function by @entity5 , @entity6 or @entity7 , which showed a negative correlation in each factor. In addition, aberrant expression of @entity6 is useful as a prognostic factor in @entity3 .

title: Cell cycle-regulated factors in XXXX .

answer: @entity3


abstract: BACKGROUND: Knowledge of the occurrence of @entity3 ( @entity3 ) and their allergens in domestic locations is important when planning intervention. OBJECTIVE: The aim of this study was to describe the distribution of HDMs and their allergens before intervention in multiple locations in the homes of newly diagnosed @entity1 @entity0 with a known high @entity4 concentration in their mattress dust. METHODS: Dust was collected from ten locations in the homes of eight @entity1 @entity0 . Dust was analysed for allergen content with ELISAs for Der f 1, Der @entity2 ; and @entity3 were counted. Total allergen concentrations ( micro g @entity4 dust) were expressed as the sum of Der f 1, Der @entity2 . RESULTS: On mattresses the median concentration was 86 micro g @entity4 dust (range 30-288) and 188 mites/g dust (range 12-1910). @entity4 exceeded 10 micro g/g dust in mattresses (8/8), duvets/pillows (3/8), a bedroom carpet (1/1), a living room carpet (1/6), upholstered furniture (2/8) and a curtain (1/5). Uncarpeted floors, upholstered furniture, bookshelves and walls had significantly lower @entity4 concentration than the mattresses. The relative contribution of Der @entity2 , Der f 1 or Der m 1 to @entity4 was related to homes, rather than to the location. Der m 1 only occurred in minute amounts. CONCLUSION: For @entity3 intervention, our results indicate that priority should be given to the removal of allergens from mattresses, and in addition from carpets, duvets/pillows and upholstered furniture. Dust from walls, uncarpeted floors, bookshelves and curtains appear to contribute insignificantly to the domestic @entity3 allergen load.

title: House dust mites and their allergens at selected locations in the homes of house dust mite-allergic XXXX .

answer: @entity0


abstract: Intradermal skin testing is widely used to determine the causative drugs of presumed anaphylactic anaesthetic reactions. This paper sets out to evaluate the usefulness of skin tests, both intradermal and prick testing, in the prediction of anaesthetic reactions. The muscle relaxant drugs @entity1 and @entity2 were chosen for study since they are known to produce a high incidence of minor histaminoid reactions. A trial was conducted in 22 female @entity0 about to undergo elective gynaecological surgery for non-malignant conditions. In intradermal tests, positive wheal and flare reactions to one or other relaxant (diluted 1 in 1,000) occurred in 17 @entity0 and reactions to both drugs in 11 @entity0 . Despite this high incidence of positive reactions, none of the @entity0 had received either drug previously, a view confirmed by the negative results of prick testing. Likewise, when anaesthetized for surgery using @entity2 or @entity1 allocated randomly, the minor histaminoid manifestations observed showed no correlation whatsoever with the intradermal tests results. The results of the trial, combined with external reports to this centre, indicate that intradermal testing of anaesthetic drugs, particularly muscle relaxants, produces a high incidence of false positive results. This probably reflects their pharmacological activity rather than antigenicity. It is recommended, therefore, that skin testing should be reserved for situations in which there are strong indications from laboratory tests, backed by case history, of immune sensitization.

title: Skin testing in the investigation of reactions to intravenous anaesthetic drugs. A prospective trial of @entity2 and XXXX .

answer: @entity1


abstract: Intradermal skin testing is widely used to determine the causative drugs of presumed anaphylactic anaesthetic reactions. This paper sets out to evaluate the usefulness of skin tests, both intradermal and prick testing, in the prediction of anaesthetic reactions. The muscle relaxant drugs @entity1 and @entity2 were chosen for study since they are known to produce a high incidence of minor histaminoid reactions. A trial was conducted in 22 female @entity0 about to undergo elective gynaecological surgery for non-malignant conditions. In intradermal tests, positive wheal and flare reactions to one or other relaxant (diluted 1 in 1,000) occurred in 17 @entity0 and reactions to both drugs in 11 @entity0 . Despite this high incidence of positive reactions, none of the @entity0 had received either drug previously, a view confirmed by the negative results of prick testing. Likewise, when anaesthetized for surgery using @entity2 or @entity1 allocated randomly, the minor histaminoid manifestations observed showed no correlation whatsoever with the intradermal tests results. The results of the trial, combined with external reports to this centre, indicate that intradermal testing of anaesthetic drugs, particularly muscle relaxants, produces a high incidence of false positive results. This probably reflects their pharmacological activity rather than antigenicity. It is recommended, therefore, that skin testing should be reserved for situations in which there are strong indications from laboratory tests, backed by case history, of immune sensitization.

title: Skin testing in the investigation of reactions to intravenous anaesthetic drugs. A prospective trial of XXXX and @entity1 .

answer: @entity2


abstract: The gut immune system is an essential part of the barrier function of the gut. At weaning, major changes can be expected in the number and subset composition of lymphocytes in the small intestine since the gut is exposed to a wide variety of food and microbial antigens, especially when @entity0 milk is gradually replaced by weaning foods. The purpose of this study was to evaluate the changes in small intestine lymphocyte subsets in @entity1 during weaning. BALB/c male @entity1 at weaning (3 wk old) were fed a nonpurified diet for 18 d and were killed at different times (0, 4, 7, 12 and 18 d). Lymphocyte populations from lamina propria (LPL), Peyer's patches (PPL) and intestinal epithelium (IEL) were isolated. The expression of different antigens ( @entity5 , @entity2 , @entity3 , @entity4 , @entity7 and @entity6 ) in those lymphocyte populations was analyzed by flow cytometry. The percentages of cells expressing T-cell antigens, such as @entity5 , were significantly higher in LPL during weaning compared to d 0. The percentages of cells expressing @entity3 and @entity4 increased in both IEL and LPL. However, the percentage of @entity2 + cells tended (P = 0.07) to decrease in IEL and to increase in LPL. The percentages of cells expressing B-cell antigens, such as @entity7 or @entity6 R in PPL increased. Changes in the specific phenotypes of intestinal lymphocyte populations at weaning are apparently related to the maturation of the intestinal immune system during early life. Thus, B cells increase in PPL and T cell increase in IEL and LPL.

title: Absolute counts and distribution of lymphocyte subsets in small intestine of BALB/c XXXX change during weaning.

answer: @entity1


abstract: To evaluate functional recovery in 20 consecutive @entity0 with @entity1 who received recombinant tissue-type plasminogen activator, serial two-dimensional echocardiograms were performed before and immediately after @entity4 administration and at 1 and 10 days postinfarction. @entity4 was administered intravenously (17 @entity0 ) or by intracoronary infusion (3 @entity0 ) after angiographic confirmation of total occlusion. Reperfusion, documented by angiography, occurred in 13 of the 20 @entity0 . The mean time from onset of @entity2 to thrombolysis was 5.1 +/- 1.1 hours. Echocardiograms were evaluated for regional function with a visual semiquantitative scoring system by two independent observers who had no knowledge of @entity0 identity, temporal sequence, therapy or effect of therapy. There was no immediate or 24 hour improvement in wall motion. At day 10 compared with pretreatment, 28 of 33 reperfused @entity3 zone segments versus 6 of 20 nonreperfused @entity3 segments demonstrated improved wall motion (p = 0.01). This improvement did not relate to time from onset of @entity2 to successful thrombolysis. Of reperfused @entity3 zone segments in the distribution of coronary artery balloon dilation, 19 of 23 segments exhibited improvement versus 7 of 17 (reperfused, no angioplasty) and 6 of 20 (nonreperfused, no angioplasty) segments (p = 0.001). Infarct zone segments reperfused at the time of ongoing @entity2 demonstrated functional recovery compared with segments reperfused in the absence of @entity2 (18 of 23 versus 10 of 20, respectively; p = 0.05). Thus, in this uncontrolled series, there was echocardiographically detectable improvement in function of reperfused @entity3 segments 10 days after coronary thrombolysis with recombinant @entity4 .

title: Regional wall motion improvement after coronary thrombolysis with recombinant XXXX : importance of coronary angioplasty.

answer: @entity4


abstract: In this study the relationship between @entity5 and the following factors was studied: Clinical findings, frequency and duration of absenteeism, social situation, @entity6 . The sample studied included 220 @entity0 (participation frequency 86%) between the ages of 16-65 who had either acutely declared themselves unable to work because of @entity5 (acute @entity0 , n = 50) or who had been ill because of @entity5 for one month (subacute @entity0 , n = 50) or for three months (chronic @entity0 , n = 70). A control group (n = 50) consisting of @entity0 who had not been absent at all from work the last year was also included. Information regarding the @entity0 ' socio-economic situation, previous and present illnesses, further sick-listing during the one year follow-up period and the duration of absenteeism was obtained from the records of the Department of Health Insurance. The median age for @entity0 (68%) in the four different groups was 46, 46, 46 and 48.5, respectively. The corresponding figures for @entity0 were 50, 33, 33 and 49 years. Twenty percent were of foreign extraction. The proportion of foreigners in the group of non- @entity0 (n=33) was higher (39%) and in this group there was a significantly greater frequency of previous episodes of ill health of short duration (less than or equal to 7 days + no certificate of ill health). Despite a careful clinical examination it was not possible to find any objective signs amongst 51% (86) of the @entity0 . These @entity0 exhibited normal motion of the back, normal musculature, no signs of neurologic involvement, negative straight-leg-raising test, no fixed @entity2 position and no @entity2 during percussion or palpation despite the fact they had subjective symptoms. The proportion of @entity0 without objective findings increased with increased duration of absenteeism. Forty percent of the acute back @entity0 displayed no objective findings. The corresponding figures for the subacute and chronic back @entity0 groups were 34% and 70%, respectively. In the group without objective findings but with @entity4 (greater than 3 months) there was an increased frequency of Waddell's non-organic signs compared with the group with objective findings. Psychological and social problems increased with increasing duration of absenteeism. There were significantly more @entity0 with @entity1 , signs of @entity3 and early retirement in the three months group compared to the remaining groups.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Acute, subacute and chronic XXXX : clinical symptoms, absenteeism and working environment.

answer: @entity5


abstract: AIM: To examine cardiovascular health benefits of foods containing a whole @entity2 extract. METHODS: The study design was a randomized, placebo-controlled crossover trial of consuming soy-based milk and yoghurt (treatment) or equivalent dairy products (control) for 5 weeks each. Twenty-six mildly hypercholesterolaemic and/or @entity0 volunteers were recruited from the community as study volunteers, of which 23 completed. Main outcome measures included clinic and ambulatory blood pressure, arterial compliance, lipids, @entity4 and @entity6 in fasted blood and 24-hour urinary @entity5 excretion. Nutrient intakes were assessed initially and after each 5-week period. Multiple regression analyses were used to determine predictor variables in statistical models; order effects were tested by repeated measures ANOVA. Changes in Lp(a) were determined by Wilcoxon signed ranks tests; other differences between treatment and control were assessed by t tests. RESULTS: Plasma and urinary @entity6 were markedly increased by whole soy supplementation but there were no overall differences in plasma lipids, blood pressure or arterial compliance between the soy and dairy diets. However, in 8 equol-positive subjects (equol detected in either plasma or urine), retrospective analysis revealed significant reductions in total @entity1 (8.5%), LDL @entity1 (10%), LDL:HDL ratio (13.5%), plasma @entity3 (21%) and lipoprotein(a) (11%) with the soy diet. These reductions were independent of changes in polyunsaturated fat and other macronutrient intakes. CONCLUSIONS: Regular consumption of whole @entity2 milk and yogurt products had no effect on plasma lipids, blood pressure or arterial compliance in at-risk subjects, despite substantially increasing @entity5 levels in blood and urine. Retrospective analysis suggests that improvement of plasma lipids may have been limited to equol-positive subjects.

title: Limited lipid-lowering effects of regular consumption of whole XXXX foods.

answer: @entity2