abstract: STUDY DESIGN: This retrospective study evaluates two groups of @entity0 with @entity5 and @entity4 , treated with two different surgical stabilization methods. OBJECTIVE: To determine whether fixation to the sacropelvis is always necessary for adequate stabilization of @entity5 in @entity4 . SUMMARY OF BACKGROUND DATA: Pelvic fixation is generally recommended for @entity5 in @entity4 . Recent studies describe a more selective approach toward lumbar or pelvic fixation. Pelvic fixation is reserved for larger curves and established pelvic tilt. METHODS: Fifty cases of @entity4 , operated in two different centers and followed up for a minimum of 3 years, were reviewed. In the first group (Oswestry), 31 @entity0 had fixation to the pelvis, using standard Luque instrumentation and pelvic fixation. The Galveston technique was used in 9 cases and L-rod configuration in 22 cases. In the second group (Nottingham), 19 cases had fixation to L5 using pedicle screws in the lumbar spine and sublaminar wires in the thoracic spine. These cases were operated on early, usually shortly after becoming wheelchair dependent. RESULTS: In the pelvic fixation group, the mean age at the time of surgery was 14 years, and forced vital capacity was 44%. The mean Cobb angle and @entity3 were 48 degrees and 19.8 degrees at the time of surgery, 16.7 degrees and 7.2 degrees immediately after surgery, and 22 degrees and 11.6 degrees at the final follow-up (mean 4.6 years), respectively. The mean @entity1 was 4.1 L, and the average hospital stay was 17 days. There were five major complications, including a deep wound @entity2 in one case, revision of instrumentation prominence at the proximal end in two cases, and loosening of pelvic fixation in two cases. In the lumbar fixation group, the mean age at the time of surgery was 11.7 years, and forced vital capacity was 58%. The mean Cobb angle and @entity3 were 19.8 degrees and 9 degrees at the time of surgery, 3.2 degrees and 2.2 degrees immediately after surgery, and 5.2 degrees and 2.9 degrees at the final follow-up (mean 3.5 years), respectively. The mean estimated @entity1 (3.3 L) and mean hospital stay (7.7 days) were much less compared with the pelvic fixation group. @entity3 was corrected and maintained below 10 degrees in all but two cases, who had an initial @entity3 exceeding 20 degrees. One @entity0 had instrumentation failure at the proximal end, and one had a deep wound @entity2 . CONCLUSION: Lumbar fixation to L5 is adequate if the surgery is performed early, soon after becoming wheelchair bound, and with smaller curves and minimal @entity3 . Use of pedicle screws in lumbar spine provides a solid foundation to maintain the correction over the period of relatively short life expectancy of these @entity0 . Pelvic fixation may be necessary in older @entity0 , who have larger curves and established @entity3 . In the presence of deteriorating lung function, this is associated with a greater morbidity and higher complication rate.

title: Pelvic or lumbar fixation for the surgical management of XXXX in @entity4 .

answer: @entity5


abstract: STUDY DESIGN: This retrospective study evaluates two groups of @entity0 with @entity5 and @entity4 , treated with two different surgical stabilization methods. OBJECTIVE: To determine whether fixation to the sacropelvis is always necessary for adequate stabilization of @entity5 in @entity4 . SUMMARY OF BACKGROUND DATA: Pelvic fixation is generally recommended for @entity5 in @entity4 . Recent studies describe a more selective approach toward lumbar or pelvic fixation. Pelvic fixation is reserved for larger curves and established pelvic tilt. METHODS: Fifty cases of @entity4 , operated in two different centers and followed up for a minimum of 3 years, were reviewed. In the first group (Oswestry), 31 @entity0 had fixation to the pelvis, using standard Luque instrumentation and pelvic fixation. The Galveston technique was used in 9 cases and L-rod configuration in 22 cases. In the second group (Nottingham), 19 cases had fixation to L5 using pedicle screws in the lumbar spine and sublaminar wires in the thoracic spine. These cases were operated on early, usually shortly after becoming wheelchair dependent. RESULTS: In the pelvic fixation group, the mean age at the time of surgery was 14 years, and forced vital capacity was 44%. The mean Cobb angle and @entity3 were 48 degrees and 19.8 degrees at the time of surgery, 16.7 degrees and 7.2 degrees immediately after surgery, and 22 degrees and 11.6 degrees at the final follow-up (mean 4.6 years), respectively. The mean @entity1 was 4.1 L, and the average hospital stay was 17 days. There were five major complications, including a deep wound @entity2 in one case, revision of instrumentation prominence at the proximal end in two cases, and loosening of pelvic fixation in two cases. In the lumbar fixation group, the mean age at the time of surgery was 11.7 years, and forced vital capacity was 58%. The mean Cobb angle and @entity3 were 19.8 degrees and 9 degrees at the time of surgery, 3.2 degrees and 2.2 degrees immediately after surgery, and 5.2 degrees and 2.9 degrees at the final follow-up (mean 3.5 years), respectively. The mean estimated @entity1 (3.3 L) and mean hospital stay (7.7 days) were much less compared with the pelvic fixation group. @entity3 was corrected and maintained below 10 degrees in all but two cases, who had an initial @entity3 exceeding 20 degrees. One @entity0 had instrumentation failure at the proximal end, and one had a deep wound @entity2 . CONCLUSION: Lumbar fixation to L5 is adequate if the surgery is performed early, soon after becoming wheelchair bound, and with smaller curves and minimal @entity3 . Use of pedicle screws in lumbar spine provides a solid foundation to maintain the correction over the period of relatively short life expectancy of these @entity0 . Pelvic fixation may be necessary in older @entity0 , who have larger curves and established @entity3 . In the presence of deteriorating lung function, this is associated with a greater morbidity and higher complication rate.

title: Pelvic or lumbar fixation for the surgical management of @entity5 in XXXX .

answer: @entity4


abstract: OBJECTIVE: Recent clinical studies suggested that intrapartum maternal fever is a strong independent risk factor for neonatal @entity3 . With use of a well-studied @entity1 model of neonatal @entity2 , this study investigated the hypothesis that intraischemic @entity5 accelerates and worsens @entity8 in immature animals and examined whether apoptotic cell death machinery is involved in the underlying mechanisms. STUDY DESIGN: Seven-day-old @entity1 underwent a combination of left common carotid artery ligation and exposure to 8% @entity0 for 15 minutes (n = 32 @entity1 ). During the 15-minute @entity6 insult, body temperature was elevated to 40 degrees C in 16 animals ( @entity6 ), and was maintained at 37 degrees C in 16 animals (normothermic @entity6 insult group). Then both groups were placed in the same chamber in a water bath at 37 degrees C for 24 hours and finally returned to the mothers. @entity11 activity was assessed 36 hours after the @entity2 . One week later, @entity10 immunostaining was used to examine @entity7 . RESULTS: Intraischemic @entity5 was shown to activate the @entity9 activity 36 hours after @entity6 - @entity2 while @entity9 was activated insignificantly in the normothermic @entity6 insult group at that time. The @entity6 also showed a reduced @entity10 -positive area 7 days after @entity6 - @entity2 compared with that in the normothermia group. CONCLUSION: @entity5 during @entity6 - @entity2 makes the immature brain inordinately susceptible to @entity2 and causes @entity8 , even if @entity2 is so mild that it causes no or @entity4 by itself. This effect may be mediated by the escalation of the apoptotic cell death pathway in the immature animal.

title: Effects of XXXX on @entity3 in the immature @entity1 : its influence on @entity11 protease.

answer: @entity5


abstract: OBJECTIVE: Recent clinical studies suggested that intrapartum maternal fever is a strong independent risk factor for neonatal @entity3 . With use of a well-studied @entity1 model of neonatal @entity2 , this study investigated the hypothesis that intraischemic @entity5 accelerates and worsens @entity8 in immature animals and examined whether apoptotic cell death machinery is involved in the underlying mechanisms. STUDY DESIGN: Seven-day-old @entity1 underwent a combination of left common carotid artery ligation and exposure to 8% @entity0 for 15 minutes (n = 32 @entity1 ). During the 15-minute @entity6 insult, body temperature was elevated to 40 degrees C in 16 animals ( @entity6 ), and was maintained at 37 degrees C in 16 animals (normothermic @entity6 insult group). Then both groups were placed in the same chamber in a water bath at 37 degrees C for 24 hours and finally returned to the mothers. @entity11 activity was assessed 36 hours after the @entity2 . One week later, @entity10 immunostaining was used to examine @entity7 . RESULTS: Intraischemic @entity5 was shown to activate the @entity9 activity 36 hours after @entity6 - @entity2 while @entity9 was activated insignificantly in the normothermic @entity6 insult group at that time. The @entity6 also showed a reduced @entity10 -positive area 7 days after @entity6 - @entity2 compared with that in the normothermia group. CONCLUSION: @entity5 during @entity6 - @entity2 makes the immature brain inordinately susceptible to @entity2 and causes @entity8 , even if @entity2 is so mild that it causes no or @entity4 by itself. This effect may be mediated by the escalation of the apoptotic cell death pathway in the immature animal.

title: Effects of @entity5 on @entity3 in the immature @entity1 : its influence on XXXX protease.

answer: @entity11


abstract: OBJECTIVE: Recent clinical studies suggested that intrapartum maternal fever is a strong independent risk factor for neonatal @entity3 . With use of a well-studied @entity1 model of neonatal @entity2 , this study investigated the hypothesis that intraischemic @entity5 accelerates and worsens @entity8 in immature animals and examined whether apoptotic cell death machinery is involved in the underlying mechanisms. STUDY DESIGN: Seven-day-old @entity1 underwent a combination of left common carotid artery ligation and exposure to 8% @entity0 for 15 minutes (n = 32 @entity1 ). During the 15-minute @entity6 insult, body temperature was elevated to 40 degrees C in 16 animals ( @entity6 ), and was maintained at 37 degrees C in 16 animals (normothermic @entity6 insult group). Then both groups were placed in the same chamber in a water bath at 37 degrees C for 24 hours and finally returned to the mothers. @entity11 activity was assessed 36 hours after the @entity2 . One week later, @entity10 immunostaining was used to examine @entity7 . RESULTS: Intraischemic @entity5 was shown to activate the @entity9 activity 36 hours after @entity6 - @entity2 while @entity9 was activated insignificantly in the normothermic @entity6 insult group at that time. The @entity6 also showed a reduced @entity10 -positive area 7 days after @entity6 - @entity2 compared with that in the normothermia group. CONCLUSION: @entity5 during @entity6 - @entity2 makes the immature brain inordinately susceptible to @entity2 and causes @entity8 , even if @entity2 is so mild that it causes no or @entity4 by itself. This effect may be mediated by the escalation of the apoptotic cell death pathway in the immature animal.

title: Effects of @entity5 on XXXX in the immature @entity1 : its influence on @entity11 protease.

answer: @entity3


abstract: OBJECTIVE: Recent clinical studies suggested that intrapartum maternal fever is a strong independent risk factor for neonatal @entity3 . With use of a well-studied @entity1 model of neonatal @entity2 , this study investigated the hypothesis that intraischemic @entity5 accelerates and worsens @entity8 in immature animals and examined whether apoptotic cell death machinery is involved in the underlying mechanisms. STUDY DESIGN: Seven-day-old @entity1 underwent a combination of left common carotid artery ligation and exposure to 8% @entity0 for 15 minutes (n = 32 @entity1 ). During the 15-minute @entity6 insult, body temperature was elevated to 40 degrees C in 16 animals ( @entity6 ), and was maintained at 37 degrees C in 16 animals (normothermic @entity6 insult group). Then both groups were placed in the same chamber in a water bath at 37 degrees C for 24 hours and finally returned to the mothers. @entity11 activity was assessed 36 hours after the @entity2 . One week later, @entity10 immunostaining was used to examine @entity7 . RESULTS: Intraischemic @entity5 was shown to activate the @entity9 activity 36 hours after @entity6 - @entity2 while @entity9 was activated insignificantly in the normothermic @entity6 insult group at that time. The @entity6 also showed a reduced @entity10 -positive area 7 days after @entity6 - @entity2 compared with that in the normothermia group. CONCLUSION: @entity5 during @entity6 - @entity2 makes the immature brain inordinately susceptible to @entity2 and causes @entity8 , even if @entity2 is so mild that it causes no or @entity4 by itself. This effect may be mediated by the escalation of the apoptotic cell death pathway in the immature animal.

title: Effects of @entity5 on @entity3 in the immature XXXX : its influence on @entity11 protease.

answer: @entity1


abstract: INTRODUCTION: @entity3 is a single-agent @entity1 , which is the major cause of @entity2 around the world. Approximately one third of the world's population is infected with @entity3 ( @entity3 ) bacilli and at risk of developing active @entity3 . The purpose of this study was determined the impact of education based on health belief model in promoting behavior of smear-positive @entity4 among @entity0 in Chabahar city, Iran. MATERIAL AND METHODS: Of the 80 smear-positive @entity4 who referred to health centers in Chabahar voluntarily participated in this interventional study. The data collected using questionnaire based on health belief model. The data were analyzed by using paired t-test, independent t-test, pearson correlation and chi-square test with SPSS 16. RESULTS: The cognitive skills were increased significantly from 6.10 to 6.88 after intervention. All behavioral skills were increased significantly from 2.08 to 2.88 after implementing the intervention. Perceived severity was increased from11.08to12.19 significantly. Percepted benefits were enhanced significantly from 11.48 to 12.23. Mean percepted barrier was decreased significantly from 17.52 to 16.68. CONCLUSION: Findings demonstrated that implementing educational intervention programs can increase the level of knowledge and behavior of @entity0 regarding smear- positive @entity4 initiatives.

title: Impact of Educational Intervention on @entity0 Behavior with Smear-positive XXXX : A Study Using the Health Belief Model.

answer: @entity4


abstract: INTRODUCTION: @entity3 is a single-agent @entity1 , which is the major cause of @entity2 around the world. Approximately one third of the world's population is infected with @entity3 ( @entity3 ) bacilli and at risk of developing active @entity3 . The purpose of this study was determined the impact of education based on health belief model in promoting behavior of smear-positive @entity4 among @entity0 in Chabahar city, Iran. MATERIAL AND METHODS: Of the 80 smear-positive @entity4 who referred to health centers in Chabahar voluntarily participated in this interventional study. The data collected using questionnaire based on health belief model. The data were analyzed by using paired t-test, independent t-test, pearson correlation and chi-square test with SPSS 16. RESULTS: The cognitive skills were increased significantly from 6.10 to 6.88 after intervention. All behavioral skills were increased significantly from 2.08 to 2.88 after implementing the intervention. Perceived severity was increased from11.08to12.19 significantly. Percepted benefits were enhanced significantly from 11.48 to 12.23. Mean percepted barrier was decreased significantly from 17.52 to 16.68. CONCLUSION: Findings demonstrated that implementing educational intervention programs can increase the level of knowledge and behavior of @entity0 regarding smear- positive @entity4 initiatives.

title: Impact of Educational Intervention on XXXX Behavior with Smear-positive @entity4 : A Study Using the Health Belief Model.

answer: @entity0


abstract: The ability to pump and manipulate fluid at the micron-scale is a basic requirement for microfluidic platforms. Many current manipulation methods, however, require expensive and bulky external supporting equipment, which are not typically compatible for portable applications. We have developed a contactless metal electro-osmotic micropump capable of pumping conductive buffers. The pump operates using two pairs of @entity0 metal electrodes, which are activated using an external voltage source and separated from a main flow channel by a thin micron-scale @entity1 ( @entity2 ) membrane. The thin contactless membrane allows for field penetration and electro-osmotic flow within the microchannel, but eliminates electrode damage and sample contamination commonly associated with traditional DC electro-osmotic pumps that utilize electrodes in direct contact with the working fluid. Our previous work has demonstrated the effectiveness of this method in pumping deionized water. However, due to the high resistivity of @entity2 , this method proved difficult to apply towards manipulating conductive buffers. To overcome this limitation, we fabricated conductive @entity3 (CB) powder directly into the contactless @entity2 membranes. The increased electrical conductivity of the contactless @entity2 membrane significantly increased micropump performance. Using a microfluidic T-channel device and an electro-osmotic flow model, we determined the influence that CB has on pump pressure for CB weight percents varying between 0 and 20. The results demonstrate that the CB increases pump pressure by two orders of magnitude and enables effective operations with conductive buffers.

title: Contactless microfluidic pumping using microchannel-integrated XXXX composite membranes.

answer: @entity3


abstract: Background. In March 2010, ANSM (Agence Nationale de S  curit   du Medicament), the French Medical Regulatory Authority, withdrew Poly Implant Proth  se (PIP) breast implants from the market due to the use of non-medical-grade @entity4 gel. The aim of this study was to compare the removal rate (and reasons thereof) of breast implants produced by different manufacturers before the ANSM alert. Materials and Methods. From October 2006 to January 2010, 652 @entity1 received 944 implants after @entity0 surgery at the Gustave Roussy @entity2 Center, Paris (France). The complications and removal rates of the different implant brands used (PIP, Allergan, and P  rouse) were evaluated and compared. Results. PIP implants represented 50.6% of the used implants, Allergan 33.4%, and P  rouse 16%. The main reasons for implant removal were @entity1 dissatisfaction due to aesthetic problems (43.2%), @entity3 (22.2%), and capsular contracture (13.6%). Two years after implantation, 82% of P  rouse implants, 79% of PIP, and 79% of Allergan were still in situ. There was no difference in removal rate among implant brands. Conclusion. Before the ANSM alert concerning the higher rupture rate of PIP breast implants, our implant removal rate did not predict PIP implant failure related to the use of nonapproved @entity4 gel.

title: Comparison of the Explantation Rate of Poly Implant Proth  se, Allergan, and P  rouse XXXX Breast Implants within the First Four Years after Reconstructive Surgery before the Poly Implant Proth  se Alert by the French Regulatory Authority.

answer: @entity4


abstract: There is a worsening epidemic of @entity2 and @entity0 in the world. Life style interventions including dietary changes and increase in exercise can improve @entity4 metabolism and health in general. However, standard exercise programs are strenuous, time-consuming, and thus have low long-term compliance issues. We tested the feasibility of using high frequency, low amplitude whole body vibration (WBV) therapy to improve @entity4 metabolism in young type 2 @entity0 (T2DM) @entity1 . We also aimed to investigate the postulated anti-inflammatory and cytoprotective properties of WBV. Male db/db and db/m @entity1 were exposed to high frequency, low-amplitude WBV. Outcome parameters comprised of body weight, hemoglobin A1c (HbA1c) level, as well as interleukin (IL)-17 (a marker of helper T cells), @entity8 ( @entity8 ; a marker of regulatory T cells), and @entity6 (an index of DNA injury) expression. Furthermore, a 24  h metabolic cage study was carried out immediately after the WBV protocol and fluid intake, urine excretion and urine osmolality were determined. WBV did not affect body weight but improved HbA1c levels in db/db @entity1 . Vibrated db/db @entity1 demonstrated less fluid intake and urine excretion but better urinary concentrating ability than their non-vibrated controls. Pro-inflammatory changes were significantly reduced, as indicated by reduced @entity5 but increased @entity8 expression. WBV reduced @entity6 in db/db @entity1 suggestive of cytoprotective effect. However, WBV was largely without significant effects on assessed parameters in db/m @entity1 . Collectively, our findings suggest that daily, short duration WBV may improve glycemic control, @entity9 , @entity7 , and urine osmolality in T2DM in association with reduced @entity3 . Thus, WBV may be a viable adjunctive treatment strategy in T2DM.

title: Whole body vibration therapy: a novel potential treatment for XXXX .

answer: @entity0


abstract: Recent developments in molecular cytogenetics allow the detection of genomic rearrangements at an unprecedented level leading to discoveries of previously unknown chromosomal imbalances (zygotic and post-zygotic/mosaic). These can be accompanied by a different kind of pathological genome variations, i.e. @entity4 ( @entity6 ) manifested as structural chromosomal rearrangements and low-level mosaic @entity5 . Fortunately, combining whole-genome and single-cell molecular cytogenetic techniques with bioinformatics offers an opportunity to link genomic changes to specific molecular or cellular pathology. High-resolution chromosomal SNP microarray analysis was performed to study the genome of a 15-month-aged @entity0 presented with @entity1 , @entity3 , feeding problems, @entity7 , @entity2 , and eye pathology. In addition, somatic @entity6 ( @entity6 ) were analyzed by fluorescence in situ hybridization (FISH). Interstitial 5p13.3p13.2 duplication was revealed in the index @entity0 . Moreover, @entity6 manifested almost exclusively as chromosome losses and gains ( @entity5 ) was detected. Using bioinformatic analysis of SNP array data and FISH results, @entity6 association with the genomic imbalance resulted from the duplication was proposed. The duplication was demonstrated to encompass genes implicated in cell cycle, programmed cell death, chromosome segregation and genome stability maintenance pathways as shown by an interactomic analysis. Genotype-phenotype correlations were observed, as well. To the best our knowledge, identical duplications have not been reported in the available literature. Apart from genotype-phenotype correlations, it was possible to propose a link between the duplication and @entity6 ( @entity5 ). This case study demonstrates that combining SNP array genomic analysis, bioinformatics and molecular cytogenetic evaluation of somatic genome variations is able to provide a view on cellular and molecular pathology in a personalized manner. Therefore, one can speculate that similar approaches targeting both interindividual and intercellular genomic variations could be useful for a better understanding of disease mechanisms and disease-related biological processes.

title: 5p13.3p13.2 duplication associated with @entity1 , @entity3 and @entity4 manifested as low-level XXXX .

answer: @entity5


abstract: Recent developments in molecular cytogenetics allow the detection of genomic rearrangements at an unprecedented level leading to discoveries of previously unknown chromosomal imbalances (zygotic and post-zygotic/mosaic). These can be accompanied by a different kind of pathological genome variations, i.e. @entity4 ( @entity6 ) manifested as structural chromosomal rearrangements and low-level mosaic @entity5 . Fortunately, combining whole-genome and single-cell molecular cytogenetic techniques with bioinformatics offers an opportunity to link genomic changes to specific molecular or cellular pathology. High-resolution chromosomal SNP microarray analysis was performed to study the genome of a 15-month-aged @entity0 presented with @entity1 , @entity3 , feeding problems, @entity7 , @entity2 , and eye pathology. In addition, somatic @entity6 ( @entity6 ) were analyzed by fluorescence in situ hybridization (FISH). Interstitial 5p13.3p13.2 duplication was revealed in the index @entity0 . Moreover, @entity6 manifested almost exclusively as chromosome losses and gains ( @entity5 ) was detected. Using bioinformatic analysis of SNP array data and FISH results, @entity6 association with the genomic imbalance resulted from the duplication was proposed. The duplication was demonstrated to encompass genes implicated in cell cycle, programmed cell death, chromosome segregation and genome stability maintenance pathways as shown by an interactomic analysis. Genotype-phenotype correlations were observed, as well. To the best our knowledge, identical duplications have not been reported in the available literature. Apart from genotype-phenotype correlations, it was possible to propose a link between the duplication and @entity6 ( @entity5 ). This case study demonstrates that combining SNP array genomic analysis, bioinformatics and molecular cytogenetic evaluation of somatic genome variations is able to provide a view on cellular and molecular pathology in a personalized manner. Therefore, one can speculate that similar approaches targeting both interindividual and intercellular genomic variations could be useful for a better understanding of disease mechanisms and disease-related biological processes.

title: 5p13.3p13.2 duplication associated with XXXX , @entity3 and @entity4 manifested as low-level @entity5 .

answer: @entity1


abstract: Recent developments in molecular cytogenetics allow the detection of genomic rearrangements at an unprecedented level leading to discoveries of previously unknown chromosomal imbalances (zygotic and post-zygotic/mosaic). These can be accompanied by a different kind of pathological genome variations, i.e. @entity4 ( @entity6 ) manifested as structural chromosomal rearrangements and low-level mosaic @entity5 . Fortunately, combining whole-genome and single-cell molecular cytogenetic techniques with bioinformatics offers an opportunity to link genomic changes to specific molecular or cellular pathology. High-resolution chromosomal SNP microarray analysis was performed to study the genome of a 15-month-aged @entity0 presented with @entity1 , @entity3 , feeding problems, @entity7 , @entity2 , and eye pathology. In addition, somatic @entity6 ( @entity6 ) were analyzed by fluorescence in situ hybridization (FISH). Interstitial 5p13.3p13.2 duplication was revealed in the index @entity0 . Moreover, @entity6 manifested almost exclusively as chromosome losses and gains ( @entity5 ) was detected. Using bioinformatic analysis of SNP array data and FISH results, @entity6 association with the genomic imbalance resulted from the duplication was proposed. The duplication was demonstrated to encompass genes implicated in cell cycle, programmed cell death, chromosome segregation and genome stability maintenance pathways as shown by an interactomic analysis. Genotype-phenotype correlations were observed, as well. To the best our knowledge, identical duplications have not been reported in the available literature. Apart from genotype-phenotype correlations, it was possible to propose a link between the duplication and @entity6 ( @entity5 ). This case study demonstrates that combining SNP array genomic analysis, bioinformatics and molecular cytogenetic evaluation of somatic genome variations is able to provide a view on cellular and molecular pathology in a personalized manner. Therefore, one can speculate that similar approaches targeting both interindividual and intercellular genomic variations could be useful for a better understanding of disease mechanisms and disease-related biological processes.

title: 5p13.3p13.2 duplication associated with @entity1 , @entity3 and XXXX manifested as low-level @entity5 .

answer: @entity4


abstract: Recent developments in molecular cytogenetics allow the detection of genomic rearrangements at an unprecedented level leading to discoveries of previously unknown chromosomal imbalances (zygotic and post-zygotic/mosaic). These can be accompanied by a different kind of pathological genome variations, i.e. @entity4 ( @entity6 ) manifested as structural chromosomal rearrangements and low-level mosaic @entity5 . Fortunately, combining whole-genome and single-cell molecular cytogenetic techniques with bioinformatics offers an opportunity to link genomic changes to specific molecular or cellular pathology. High-resolution chromosomal SNP microarray analysis was performed to study the genome of a 15-month-aged @entity0 presented with @entity1 , @entity3 , feeding problems, @entity7 , @entity2 , and eye pathology. In addition, somatic @entity6 ( @entity6 ) were analyzed by fluorescence in situ hybridization (FISH). Interstitial 5p13.3p13.2 duplication was revealed in the index @entity0 . Moreover, @entity6 manifested almost exclusively as chromosome losses and gains ( @entity5 ) was detected. Using bioinformatic analysis of SNP array data and FISH results, @entity6 association with the genomic imbalance resulted from the duplication was proposed. The duplication was demonstrated to encompass genes implicated in cell cycle, programmed cell death, chromosome segregation and genome stability maintenance pathways as shown by an interactomic analysis. Genotype-phenotype correlations were observed, as well. To the best our knowledge, identical duplications have not been reported in the available literature. Apart from genotype-phenotype correlations, it was possible to propose a link between the duplication and @entity6 ( @entity5 ). This case study demonstrates that combining SNP array genomic analysis, bioinformatics and molecular cytogenetic evaluation of somatic genome variations is able to provide a view on cellular and molecular pathology in a personalized manner. Therefore, one can speculate that similar approaches targeting both interindividual and intercellular genomic variations could be useful for a better understanding of disease mechanisms and disease-related biological processes.

title: 5p13.3p13.2 duplication associated with @entity1 , XXXX and @entity4 manifested as low-level @entity5 .

answer: @entity3


abstract: The role of telomerase activity in @entity1 progression of @entity5 is not well understood. Therefore, we investigated 72 @entity5 of different histological subtypes for an association between telomeric lengths and telomerase activity, and assessed the association between the catalytic subunit @entity0 telomerase reverse transcriptase ( @entity6 ) and its activator @entity3 . Telomeric repeat fragment lengths were determined using radioactive DNA-fingerprint analysis with the telomere-specific probe (TTAGGG)(3), whereas telomerase activity was ascertained using the non-radioactive TRAP-assay. To evaluate the expression of @entity6 and @entity3 , we applied real-time RT-PCR using a LightCycler. Eight @entity1 were investigated by microdissection. The @entity4 -proliferation index and @entity6 and @entity3 protein expression were determined immunohistochemically. Genetic alterations showed a high degree of @entity1 specificity. Highly malignant myxoid/round cell @entity5 showed the longest telomeres, the strongest telomerase activity, and the highest @entity6 and @entity3 expression levels compared with the pure myxoid variants (p < 0.001), which are of low malignancy. @entity5 was characterized by zero or low @entity6 and @entity3 expression and telomerase activity, but long telomeres, underlining their different pathogenetic pathway. Elevated gene expression was accompanied by protein immunopositivity. @entity4 -proliferation index did not correlate with other molecular markers. We conclude that @entity6 and @entity3 expression are associated with telomerase activity in @entity5 . Elevated @entity6 and @entity3 expression as well as high telomerase activity play a role in the @entity1 progression of this @entity2 type. Nevertheless, each histological subtype of @entity5 is defined by a specific molecular pattern. Telomerase activation is the most common pathway in @entity5 maintaining telomeric length.

title: Elevated telomerase activity, XXXX -, and @entity6 mRNA expression: association with @entity1 progression in @entity1 .

answer: @entity3


abstract: The role of telomerase activity in @entity1 progression of @entity5 is not well understood. Therefore, we investigated 72 @entity5 of different histological subtypes for an association between telomeric lengths and telomerase activity, and assessed the association between the catalytic subunit @entity0 telomerase reverse transcriptase ( @entity6 ) and its activator @entity3 . Telomeric repeat fragment lengths were determined using radioactive DNA-fingerprint analysis with the telomere-specific probe (TTAGGG)(3), whereas telomerase activity was ascertained using the non-radioactive TRAP-assay. To evaluate the expression of @entity6 and @entity3 , we applied real-time RT-PCR using a LightCycler. Eight @entity1 were investigated by microdissection. The @entity4 -proliferation index and @entity6 and @entity3 protein expression were determined immunohistochemically. Genetic alterations showed a high degree of @entity1 specificity. Highly malignant myxoid/round cell @entity5 showed the longest telomeres, the strongest telomerase activity, and the highest @entity6 and @entity3 expression levels compared with the pure myxoid variants (p < 0.001), which are of low malignancy. @entity5 was characterized by zero or low @entity6 and @entity3 expression and telomerase activity, but long telomeres, underlining their different pathogenetic pathway. Elevated gene expression was accompanied by protein immunopositivity. @entity4 -proliferation index did not correlate with other molecular markers. We conclude that @entity6 and @entity3 expression are associated with telomerase activity in @entity5 . Elevated @entity6 and @entity3 expression as well as high telomerase activity play a role in the @entity1 progression of this @entity2 type. Nevertheless, each histological subtype of @entity5 is defined by a specific molecular pattern. Telomerase activation is the most common pathway in @entity5 maintaining telomeric length.

title: Elevated telomerase activity, @entity3 -, and XXXX mRNA expression: association with @entity1 progression in @entity1 .

answer: @entity6


abstract: The role of telomerase activity in @entity1 progression of @entity5 is not well understood. Therefore, we investigated 72 @entity5 of different histological subtypes for an association between telomeric lengths and telomerase activity, and assessed the association between the catalytic subunit @entity0 telomerase reverse transcriptase ( @entity6 ) and its activator @entity3 . Telomeric repeat fragment lengths were determined using radioactive DNA-fingerprint analysis with the telomere-specific probe (TTAGGG)(3), whereas telomerase activity was ascertained using the non-radioactive TRAP-assay. To evaluate the expression of @entity6 and @entity3 , we applied real-time RT-PCR using a LightCycler. Eight @entity1 were investigated by microdissection. The @entity4 -proliferation index and @entity6 and @entity3 protein expression were determined immunohistochemically. Genetic alterations showed a high degree of @entity1 specificity. Highly malignant myxoid/round cell @entity5 showed the longest telomeres, the strongest telomerase activity, and the highest @entity6 and @entity3 expression levels compared with the pure myxoid variants (p < 0.001), which are of low malignancy. @entity5 was characterized by zero or low @entity6 and @entity3 expression and telomerase activity, but long telomeres, underlining their different pathogenetic pathway. Elevated gene expression was accompanied by protein immunopositivity. @entity4 -proliferation index did not correlate with other molecular markers. We conclude that @entity6 and @entity3 expression are associated with telomerase activity in @entity5 . Elevated @entity6 and @entity3 expression as well as high telomerase activity play a role in the @entity1 progression of this @entity2 type. Nevertheless, each histological subtype of @entity5 is defined by a specific molecular pattern. Telomerase activation is the most common pathway in @entity5 maintaining telomeric length.

title: Elevated telomerase activity, @entity3 -, and @entity6 mRNA expression: association with XXXX progression in @entity1 .

answer: @entity1


abstract: The role of telomerase activity in @entity1 progression of @entity5 is not well understood. Therefore, we investigated 72 @entity5 of different histological subtypes for an association between telomeric lengths and telomerase activity, and assessed the association between the catalytic subunit @entity0 telomerase reverse transcriptase ( @entity6 ) and its activator @entity3 . Telomeric repeat fragment lengths were determined using radioactive DNA-fingerprint analysis with the telomere-specific probe (TTAGGG)(3), whereas telomerase activity was ascertained using the non-radioactive TRAP-assay. To evaluate the expression of @entity6 and @entity3 , we applied real-time RT-PCR using a LightCycler. Eight @entity1 were investigated by microdissection. The @entity4 -proliferation index and @entity6 and @entity3 protein expression were determined immunohistochemically. Genetic alterations showed a high degree of @entity1 specificity. Highly malignant myxoid/round cell @entity5 showed the longest telomeres, the strongest telomerase activity, and the highest @entity6 and @entity3 expression levels compared with the pure myxoid variants (p < 0.001), which are of low malignancy. @entity5 was characterized by zero or low @entity6 and @entity3 expression and telomerase activity, but long telomeres, underlining their different pathogenetic pathway. Elevated gene expression was accompanied by protein immunopositivity. @entity4 -proliferation index did not correlate with other molecular markers. We conclude that @entity6 and @entity3 expression are associated with telomerase activity in @entity5 . Elevated @entity6 and @entity3 expression as well as high telomerase activity play a role in the @entity1 progression of this @entity2 type. Nevertheless, each histological subtype of @entity5 is defined by a specific molecular pattern. Telomerase activation is the most common pathway in @entity5 maintaining telomeric length.

title: Elevated telomerase activity, @entity3 -, and @entity6 mRNA expression: association with @entity1 progression in XXXX .

answer: @entity1


abstract: @entity5 -gel-derived @entity4 coatings are known to promote bonelike @entity2 formation on their surfaces in vitro and in vivo. @entity2 integrates into bone tissue. In some clinical applications, the surface of an implant is simultaneously interfaced with soft and hard tissues, so it should match the properties of both. A new method is introduced for treating the coatings locally in a controlled manner. The local densification of sol-gel-derived titania coatings on @entity3 substrates with a @entity1 laser was studied in terms of the in vitro @entity0 -inducting properties. @entity1 -laser-treated multilayer coatings were compared with furnace-fired coatings prepared with the same recipe and previously shown to be bioactive. Additionally, local areas of furnace-fired multilayer coatings (previously shown to be bioactive in vitro) were further laser-treated to achieve various properties in the same implant. Topological surface properties were examined with atomic force microscopy. The formation of @entity2 was studied with Fourier transform infrared and scanning electron microscopy energy-dispersive X-ray analysis. The results show that @entity0 formation can be adjusted locally by laser treatment. @entity0 is a bonelike @entity2 . The local treatment of sol-gel-derived coatings with a @entity1 laser is a promising technique for creating implants with various properties to interface different tissues and a possible way of coating implants that do not tolerate furnace firing.

title: Local induction of XXXX formation on @entity4 coatings on @entity3 via surface treatment with a @entity1 laser.

answer: @entity0


abstract: @entity5 -gel-derived @entity4 coatings are known to promote bonelike @entity2 formation on their surfaces in vitro and in vivo. @entity2 integrates into bone tissue. In some clinical applications, the surface of an implant is simultaneously interfaced with soft and hard tissues, so it should match the properties of both. A new method is introduced for treating the coatings locally in a controlled manner. The local densification of sol-gel-derived titania coatings on @entity3 substrates with a @entity1 laser was studied in terms of the in vitro @entity0 -inducting properties. @entity1 -laser-treated multilayer coatings were compared with furnace-fired coatings prepared with the same recipe and previously shown to be bioactive. Additionally, local areas of furnace-fired multilayer coatings (previously shown to be bioactive in vitro) were further laser-treated to achieve various properties in the same implant. Topological surface properties were examined with atomic force microscopy. The formation of @entity2 was studied with Fourier transform infrared and scanning electron microscopy energy-dispersive X-ray analysis. The results show that @entity0 formation can be adjusted locally by laser treatment. @entity0 is a bonelike @entity2 . The local treatment of sol-gel-derived coatings with a @entity1 laser is a promising technique for creating implants with various properties to interface different tissues and a possible way of coating implants that do not tolerate furnace firing.

title: Local induction of @entity0 formation on @entity4 coatings on XXXX via surface treatment with a @entity1 laser.

answer: @entity3


abstract: @entity5 -gel-derived @entity4 coatings are known to promote bonelike @entity2 formation on their surfaces in vitro and in vivo. @entity2 integrates into bone tissue. In some clinical applications, the surface of an implant is simultaneously interfaced with soft and hard tissues, so it should match the properties of both. A new method is introduced for treating the coatings locally in a controlled manner. The local densification of sol-gel-derived titania coatings on @entity3 substrates with a @entity1 laser was studied in terms of the in vitro @entity0 -inducting properties. @entity1 -laser-treated multilayer coatings were compared with furnace-fired coatings prepared with the same recipe and previously shown to be bioactive. Additionally, local areas of furnace-fired multilayer coatings (previously shown to be bioactive in vitro) were further laser-treated to achieve various properties in the same implant. Topological surface properties were examined with atomic force microscopy. The formation of @entity2 was studied with Fourier transform infrared and scanning electron microscopy energy-dispersive X-ray analysis. The results show that @entity0 formation can be adjusted locally by laser treatment. @entity0 is a bonelike @entity2 . The local treatment of sol-gel-derived coatings with a @entity1 laser is a promising technique for creating implants with various properties to interface different tissues and a possible way of coating implants that do not tolerate furnace firing.

title: Local induction of @entity0 formation on @entity4 coatings on @entity3 via surface treatment with a XXXX laser.

answer: @entity1


abstract: @entity5 -gel-derived @entity4 coatings are known to promote bonelike @entity2 formation on their surfaces in vitro and in vivo. @entity2 integrates into bone tissue. In some clinical applications, the surface of an implant is simultaneously interfaced with soft and hard tissues, so it should match the properties of both. A new method is introduced for treating the coatings locally in a controlled manner. The local densification of sol-gel-derived titania coatings on @entity3 substrates with a @entity1 laser was studied in terms of the in vitro @entity0 -inducting properties. @entity1 -laser-treated multilayer coatings were compared with furnace-fired coatings prepared with the same recipe and previously shown to be bioactive. Additionally, local areas of furnace-fired multilayer coatings (previously shown to be bioactive in vitro) were further laser-treated to achieve various properties in the same implant. Topological surface properties were examined with atomic force microscopy. The formation of @entity2 was studied with Fourier transform infrared and scanning electron microscopy energy-dispersive X-ray analysis. The results show that @entity0 formation can be adjusted locally by laser treatment. @entity0 is a bonelike @entity2 . The local treatment of sol-gel-derived coatings with a @entity1 laser is a promising technique for creating implants with various properties to interface different tissues and a possible way of coating implants that do not tolerate furnace firing.

title: Local induction of @entity0 formation on XXXX coatings on @entity3 via surface treatment with a @entity1 laser.

answer: @entity4


abstract: BACKGROUND/AIM: Prediction and prevention of @entity1 remain great challenge. It is important to include in everyday medical practice determination of certain markers that could help identifying pregnant @entity0 with @entity1 . Insulinlike growth factor (IGF) is involved in the control mechanism of fetal and placental growth and development. The aim of this study was to examine the presence of @entity3 ( @entity3 ) in cervicovaginal secretion of pregnant @entity0 with symptoms of @entity1 , but with apparently intact fetal membranes and to point out a possible application of the strip test for detection of phlGFBP-1 in diagnosis of preterm premature rupture of total membranes (PPROM) in everyday medical practice. METHODS: The study was performed at the Department for Obstetrics and Gynecology, Clinical Center of Vojvodina between October 2008 and May 2009. The study included 54 pregnant @entity0 between 20-35 @entity2 ( @entity2 ), divided into two groups: the study group (16 pregnant @entity0 with symptoms of @entity1 that gave birth before 37 @entity2 ) and the control group (38 pregnant @entity0 with the normal course of pregnancy that gave birth on term). In cervicovaginal secretion of the examined pregnant @entity0 the level of @entity3 was determined by the immunochromatographic assay with monoclonal antibodies 6303 as a detecting antibody (Actim PROM test, Medix Biochemica, Kauniainen, Finland). RESULTS: Gestational age (GA) at delivery in the study group was 32.6 @entity2 and in the control group it was 38.4 @entity2 . Weight of newborns in the study group was 2,021 g and in the control group 3,430 g. IGFBP test was positive in 15 @entity0 (93.75%) of the study group, while in the control group it was positive only in 1 @entity0 (2.63%). CONCLUSION: Test on phIGFBP-1 in cervicovaginal mucus was positive in 93.75% @entity0 with @entity1 , suggesting that this test could be used in diagnosis of silent rupture of fetal membranes and in prediction of @entity1 .

title: The role of insulin-like growth factor in prediction and prevention of XXXX .

answer: @entity1


abstract: While attempting to find a suitable crosslinking reagent for biopolymers, a naturally occurring @entity4 (PA) obtained from grape seeds was selected to fix biological tissues. The @entity0 and crosslinking rate, reflected by the in vitro and in vivo degradation of fixed matrices has been studied. The shrinkage temperature of the fixed @entity1 pericardium increased from 66 to 86 degrees C. A @entity0 assay using fibroblast cultures revealed that PA is approximately 120 times less toxic than @entity3 (GA), a currently used tissue stabilizer. In vitro degradation studies showed that fixed tissue was resistant to digestion by bacterial collagenase. Crosslinks between PA and tissues can be stabilized by decreasing the dielectric constant of the solution during storage. After subcutaneous implantation for periods ranging between 3 and 6 weeks, we found no apparent degradation of the GA- or PA-fixed tissues, whereas fresh tissue controls rapidly disintegrated. Beyond 6 weeks PA crosslinks began to degrade. More fibroblasts migrated and proliferated inside the PA-fixed implants compared with GA counterparts. Tissues crosslinked with PA manifested an enhanced collagen expression and deposition and did not calcify after implantation. GA, on the other hand, even after thorough rinsing continued to be cytotoxic, inhibited collagen synthesis and encouraged @entity2 . Collagen matrices crosslinked with PA are expected to be of value in the design of matrices that will encourage cell ingrowth and proliferation, which are temporary in nature, and that are intended to regenerate or replace missing tissues, which can delay the biogradation of collagen. As such they should be of significant value in the emerging field of tissue engineering.

title: XXXX : a natural crosslinking reagent for stabilizing collagen matrices.

answer: @entity4


abstract: Study of the histology, histochemistry, and fine structure of caudal epidermal regeneration in @entity3 through restoration of a scaled form reveals that the processes involved resemble those known in lizards. Following establishment of a @entity2 ( @entity2 ), subjacent scale neogenesis involves epidermal downgrowths into the dermis. Although the process is extremely slow, and most new scales do not overlap, their epidermal coverings reestablish epidermal generation (EG) formation. As in lizards, the flat, alpha-keratogenic, @entity2 cells contain lipids as revealed by their affinity for @entity4 . A few mucous cells that store large PAS-positive mucus-like granules also occur in @entity2 . During differentiation of @entity2 cells, among the bundles of 70-nm tonofilaments are many lamellar bodies (LBs) and mucous granules (MGs) that discharge their contents into the cytoplasm and extracellular spaces producing a strongly PAS-positive keratinized tissue. @entity1 with mucus is a primitive characteristic for amniote vertebrates, probably related to functions as a barrier to cutaneous water loss (CWL). As scale neogenesis begins, beneath the superficial @entity2 appear 3-5 layers of irregularly shaped cells. These contain tonofilament bundles surrounded by small, round keratohyalin-like granules (KHLGs) and a keratinized matrix with beta-keratin packets and a 3-5-nm thick keratin granulation. This mixture of alpha- and beta-keratogenic capacities resembles that seen in the innermost cells of a normal @entity3 epidermal generation. As in the latter, but in contrast to both normal and regenerating lizard epidermis, no definable shedding complex with interdigitating clear layer and oberhautchen cells occurs (Alibardi and Maderson, 2003). The tortuous boundaries, and merging beta-keratin packets, identify subjacent keratinizing cells as precursors of the typical stratified, squamous beta-layer seen in long-term regenerated caudal skin wherein the entire vertical sequence of epidermal layers resembles that of normal scales. The sequence of events in caudal epidermal regeneration in @entity0 resembles that documented for lizards. Observed differences between posttrauma scale neogenesis and scale embryogenesis are responses to functional problems involved in, respectively, restoring, or forming, a barrier to CWL while accommodating rapid somatic growth.

title: Observations on the histochemistry and ultrastructure of regenerating caudal epidermis of the XXXX @entity3 (Sphenodontida, Lepidosauria, Reptilia).

answer: @entity3


abstract: Study of the histology, histochemistry, and fine structure of caudal epidermal regeneration in @entity3 through restoration of a scaled form reveals that the processes involved resemble those known in lizards. Following establishment of a @entity2 ( @entity2 ), subjacent scale neogenesis involves epidermal downgrowths into the dermis. Although the process is extremely slow, and most new scales do not overlap, their epidermal coverings reestablish epidermal generation (EG) formation. As in lizards, the flat, alpha-keratogenic, @entity2 cells contain lipids as revealed by their affinity for @entity4 . A few mucous cells that store large PAS-positive mucus-like granules also occur in @entity2 . During differentiation of @entity2 cells, among the bundles of 70-nm tonofilaments are many lamellar bodies (LBs) and mucous granules (MGs) that discharge their contents into the cytoplasm and extracellular spaces producing a strongly PAS-positive keratinized tissue. @entity1 with mucus is a primitive characteristic for amniote vertebrates, probably related to functions as a barrier to cutaneous water loss (CWL). As scale neogenesis begins, beneath the superficial @entity2 appear 3-5 layers of irregularly shaped cells. These contain tonofilament bundles surrounded by small, round keratohyalin-like granules (KHLGs) and a keratinized matrix with beta-keratin packets and a 3-5-nm thick keratin granulation. This mixture of alpha- and beta-keratogenic capacities resembles that seen in the innermost cells of a normal @entity3 epidermal generation. As in the latter, but in contrast to both normal and regenerating lizard epidermis, no definable shedding complex with interdigitating clear layer and oberhautchen cells occurs (Alibardi and Maderson, 2003). The tortuous boundaries, and merging beta-keratin packets, identify subjacent keratinizing cells as precursors of the typical stratified, squamous beta-layer seen in long-term regenerated caudal skin wherein the entire vertical sequence of epidermal layers resembles that of normal scales. The sequence of events in caudal epidermal regeneration in @entity0 resembles that documented for lizards. Observed differences between posttrauma scale neogenesis and scale embryogenesis are responses to functional problems involved in, respectively, restoring, or forming, a barrier to CWL while accommodating rapid somatic growth.

title: Observations on the histochemistry and ultrastructure of regenerating caudal epidermis of the @entity3 XXXX (Sphenodontida, Lepidosauria, Reptilia).

answer: @entity3


abstract: The development of @entity1 after open heart surgery is associated with a high mortality. Thirteen @entity0 were treated with @entity4 ( @entity4 ) for @entity1 following open heart surgery since April 1999 to December 2001. The indication of @entity4 was blood purification in 8 @entity0 and water balance control in 5 @entity0 . Two @entity0 with hemodialysis (HD) before operation returned to usual HD early after operation, and discharged. One @entity0 died of severe @entity6 , and another @entity0 died of @entity2 and @entity7 . In these 2 @entity0 , @entity4 could not withdrawn. Seven @entity0 weaned from @entity4 1 to 19 days after operation. Five of 7 @entity0 discharged, but 2 @entity0 died of @entity3 4 month after operation. The remaining 2 @entity0 could not wean from @entity4 , and were introduced HD. Only 1 of 13 @entity0 had @entity5 tendency ( @entity8 ). @entity4 did not influence the hemodynamic state and was very effective for the treatment of @entity1 in many @entity0 .

title: [Analysis of XXXX after open heart surgery].

answer: @entity4


abstract: @entity4 -like lesions were induced in @entity1 by immunizing them with type II collagen. After seven months' immunization, the @entity1 were killed and processed for histologic study. We found @entity2 in the bony cochlea, vestibule, semicircular canal, and in the regions near the oval window and round window. The @entity2 in the otic capsules were similar to @entity0 @entity4 and were characterized by the following types of microscopic appearances. 1) The classic type showed enlarged vascular spaces with congestion, macrophages, fibroblasts, and sometimes osteoclasts. 2) The fibrotic type showed vascular spaces filled with fibrous tissues. 3) The osteoporotic type had a porous appearance and was devoid of content. 4) The @entity3 type showed bone spaces partially or entirely being replaced by new bone with blue mantles and a mosaic appearance. Some @entity2 showed a mixture of the above types. The findings suggest that this animal model may provide important information to help understand the process of @entity0 @entity4 .

title: Type II collagen-induced XXXX -like lesions in @entity1 .

answer: @entity4


abstract: @entity4 -like lesions were induced in @entity1 by immunizing them with type II collagen. After seven months' immunization, the @entity1 were killed and processed for histologic study. We found @entity2 in the bony cochlea, vestibule, semicircular canal, and in the regions near the oval window and round window. The @entity2 in the otic capsules were similar to @entity0 @entity4 and were characterized by the following types of microscopic appearances. 1) The classic type showed enlarged vascular spaces with congestion, macrophages, fibroblasts, and sometimes osteoclasts. 2) The fibrotic type showed vascular spaces filled with fibrous tissues. 3) The osteoporotic type had a porous appearance and was devoid of content. 4) The @entity3 type showed bone spaces partially or entirely being replaced by new bone with blue mantles and a mosaic appearance. Some @entity2 showed a mixture of the above types. The findings suggest that this animal model may provide important information to help understand the process of @entity0 @entity4 .

title: Type II collagen-induced @entity4 -like lesions in XXXX .

answer: @entity1


abstract: BACKGROUND: Higher levels of lipoprotein(a) confer an increased risk for @entity4 ( @entity4 ). @entity9 genotype ( @entity9 ) also plays a role, the @entity9 epsilon 4 allele being associated with @entity4 . Furthermore, higher Lp(a) concentrations are correlated with @entity9 epsilon 4 allele presence. The study was performed to investigate the relationship of Lp(a) and @entity9 with the functional status of coronary arteries as evaluated by @entity3 . @entity0 AND METHODS: We studied 70 @entity0 (27 F and 43 M; mean age: 55 +/- 6 yrs.) consecutively referred for @entity4 , and 50 normal sex and age-matched controls. Total @entity2 , LDL- @entity2 , HDL- @entity2 , @entity7 , @entity8 , @entity5 , Lp(a) levels (ELISA), Lp(a) isoforms (Immuno Blotting) and @entity9 (PCR) were measured in all subjects. Only @entity4 @entity0 underwent a myocardial tomographic stress thallium scintigraphy (201Tl-SPECT); the SPECT pattern was classified as follows: no perfusion defects (unstable angina group = 1), reversible defects at stress images ( @entity1 group = 2), fixed defects ( @entity6 group = 3). RESULTS: Lp(a) medians were significantly higher than controls in group 1 (p < 0.05), 2 (p < 0.001) and 3 (p = 0.00). Low molecular weight isoforms (B, S1, S2) were significantly more frequent in all @entity4 - @entity0 vs. controls (p < 0.05), whereas @entity9 genotypes did not differ among controls and @entity0 . Multiple regression analysis showed family history (p < 0.001) to be the only independent predictive variable of @entity4 severity correlated to the scintigraphic pattern. CONCLUSION: Among the considered biological parameters in our @entity0 only Lp(a) plasma levels are related to the entity of @entity1 cardiac wall damage as evaluated by 201Tl-SPECT.

title: Correlation of lipoprotein(a) levels and myocardial stress thallium scintigraphy pattern in different entities of XXXX severity.

answer: @entity4


abstract: UNASSIGNED: In @entity1 @entity0 , oral nutrition is the preferred route of feeding since it is a significant part of the @entity0 's daily routine and contributes to the @entity0 's autonomy. It represents a privileged time to spend with family and friends, avoiding the tendency for isolation in these @entity0 . The acknowledgement that the prescribed diet is individualized, adapted and adequate to individual needs empowers the @entity0 with a feeling of control, and thus it is also a highly effective approach of psychological modulation. All these factors may potentially contribute to improve the @entity0 's quality of life and may modulate treatment morbidity. The referral to a nutrition professional responsible for the individualized dietary counseling should always be based on evidence-based decision-making plans. The implementation of individualized nutritional counseling should consider the common causes for a poor nutritional intake in elderly @entity1 @entity0 . A proper approach through counseling requires professionals with specific experience in both nutrition and oncology. Oral nutritional supplements are a simple and practical way to meet nutritional requirements when normal food intake is compromised. Ideally, oral nutritional supplements should be in addition to and not instead of meals. Supplements should be administered at a time which does not interfere with the appetite of the @entity0 . The administration after the meal theoretically potentiates the anabolic effect on protein metabolism. Supplements with high energy density (>1 kcal/ml) or enriched with x03C9;-3 @entity2 are probably the most effective.

title: Nutrition in XXXX .

answer: @entity1


abstract: PURPOSE: The purpose of this study was to compare the clinical outcomes between the groups using Ray-Tracing ( @entity3 ) and Monte-Carlo (MC) calculation algorithms for stereotactic body radiotherapy (SBRT) of @entity1 . MATERIALS AND METHODS: Thirty-five @entity0 received SBRT with CyberKnife for 47 primary or metastatic @entity1 . @entity3 was used for 22 targets in 12 @entity0 , and MC for 25 targets in 23 @entity0 . Total dose of 48 to 60 Gy was prescribed in 3 to 5 fractions on median 80% isodose line. The response rate, local control rate, and @entity4 were compared between @entity3 and MC groups. RESULTS: The response rate was lower in the @entity3 group (77.3%) compared to the MC group (100%) (p = 0.008). The response rates showed an association with the mean dose to the gross @entity2 volume, which the doses were re-calculated with MC algorithm in both groups. However, the local control rate and @entity4 did not differ between the groups. CONCLUSIONS: The clinical outcome and @entity4 of lung SBRT between the @entity3 and MC groups were similar except for the response rate when the same apparent doses were prescribed. The lower response rate in the @entity3 group, however, did not compromise the local control rates. As such, reducing the prescription dose for MC algorithm may be performed but done with caution.

title: Comparing the clinical outcomes in stereotactic body radiotherapy for XXXX between Ray-Tracing and Monte-Carlo algorithms.

answer: @entity1


abstract: @entity2 ( @entity2 ) is believed to originate from a naive B cell. However, we recently demonstrated that a subset of @entity2 displayed mutated V(H) genes. We also reported restricted use of certain V(H) genes. To assess the prognostic impact of these new findings, we performed V(H) gene analysis of 110 @entity0 , revealing that 18 (16%) @entity0 had mutated and 92 (84%) @entity0 had unmutated V(H) genes. Because the mutation rate was low in the mutated group (2.2%-6.7%), further investigation of the germline V(H) gene in T cells from 5 @entity0 with mutated V(H) genes was carried out; results showed that the unrearranged V(H) gene was identical to the published sequence. These data confirm that the base pair substitutions within the rearranged V(H) genes represent hypermutations, and indicate germinal center exposure. However, V(H) gene mutation status did not correlate with prognosis because there was no difference in clinical outcome between the unmutated and mutated groups. The most frequently used V(H) genes were V(H)3-21 (21 @entity0 ) and V(H)4-34 (19 @entity0 ). A novel finding was that V(H)3-21(+) @entity2 almost exclusively expressed lambda light chains and displayed highly restricted use of the V(lambda)3-19 gene. V(H)3-21(+) @entity0 had longer median survival than the remaining @entity0 (53 vs 34 months; P =.03), but they tended to be younger at diagnosis. The combined use of V(H)3-21/V(lambda)3-19 suggests a possible role for antigen(s) in the pathogenesis of these @entity1 and indicates that V(H)3-21(+) @entity0 constitute a new @entity2 entity.

title: Mutated VH genes and preferential VH3-21 use define new subsets of XXXX .

answer: @entity2


abstract: OBJECTIVE: Perturbations in emotional conflict adaptation, an implicit regulatory process, have been observed in adult @entity2 . However, findings remain inconsistent and restricted to adults. The current study compares conflict adaptation in youth and adults, with and without @entity2 . We predicted conflict adaptation would be present in the healthy but not the anxious groups. METHODS: In a clinic setting, 111 @entity0 (27 healthy youth, 22 anxious youth, 41 healthy adults, and 21 anxious adults) completed emotional and nonemotional conflict tasks. Groups did not differ (all p's >0.1) on intelligence quotient (IQ), gender, and socioeconomic status; age did not differ between healthy and anxious subjects in either age cohort. Separate four way mixed-design analyses of variance were conducted to test hypotheses regarding the influence of diagnosis, age group, and task type on accuracy (percent correct) and @entity1 ( @entity1 ) for conflict adaptation (incongruent trials preceded by incongruent vs. congruent trials) and conflict detection (incongruent vs. congruent trials). RESULTS: Measures of conflict adaptation did not interact with diagnosis or age. There was a significant main effect of conflict adaptation across the overall sample in the expected direction for accuracy, but not @entity1 . The well-replicated conflict detection effect also did emerge across tasks, with slower @entity1 and lower accuracy for incongruent than for congruent trials. These effects were greater for the emotional than for nonemotional tasks. Finally, there were age differences in accuracy-based conflict detection specific to the emotional task, for which the size of the effect was larger for youth than for adults. CONCLUSIONS: The current study of youth and adults did not replicate prior behavioral findings of failure to engage conflict adaptation in @entity2 . Therefore, more work is needed before widely adopting conflict adaptation paradigms as a standard neurocognitive marker for @entity2 .

title: Emotional and Nonemotional Conflict Processing in Pediatric and Adult XXXX .

answer: @entity2


abstract: PURPOSE: We investigated the cumulative probability of @entity3 remission and relapse in an adult population with @entity2 and frequent @entity3 . In addition, we determined clinical predictors of remission and relapse in this population. METHODS: IN 2003, we identified 246 @entity0 at a single center with @entity2 defined as at least one @entity3 per month and failure of at least two antiepileptic drugs. These @entity0 were followed prospectively (cohort design). We examined the cumulative probability of @entity3 remission and relapse in this population using Kaplan-Meier methodology. Clinical predictors of remission and relapse were also evaluated using Cox regression analysis. KEY FINDINGS: The estimated cumulative probability of 12-month @entity3 remission was 34.6% at 7 years in the entire population and 33.4% when limited to those without surgery. The risk for relapse after a 12-month period of @entity3 remission was 71.2% at 5 years. Negative predictors of @entity3 remission included @entity1 , @entity5 , duration of intractability, and number of antiepileptic drugs failed. @entity4 was the only negative predictor of relapse. SIGNIFICANCE: Among @entity0 with @entity2 , 5% per year enter @entity3 remission even with a follow-up of 6 years. However, a substantial proportion of these @entity0 relapse after the first year following a remission. The large proportion of @entity0 entering a significant remission gives these @entity0 hope; however, caution should be advised when discussing the likelihood of future @entity3 .

title: Remission and relapse in a XXXX population followed prospectively.

answer: @entity2


abstract: PURPOSE: Evidence from the pediatric population exists for the efficacy of ketogenic diets in reducing @entity3 frequency in @entity0 with intractable @entity1 . Recent evidence suggests that a Modified Atkins Diet may be a beneficial form of cotherapy for adult @entity0 with pharmacoresistant @entity1 . METHODS: A prospective, open-label study was performed of adults > 18 years of age with pharmacoresistant @entity1 . Carbohydrates were restricted to 20 g/day. Fluids and calories from protein and fat were allowed ad libitum. KEY FINDINGS:     Eighteen @entity0 , ages 18-55 years, were initially enrolled. Using an intent-to-treat analysis, 12% had a >50% @entity3 reduction after 3 months; 28% after 6 months, and 21% after 12 months. Response at 3 months predicted response at 12 months in 79% of @entity0 . The mean decrease in weight was 10.9 kg and the mean decrease in body mass index (BMI) was 3.8, p = 0.01. Fourteen of 18 @entity0 (78%) completed 12 months of this diet. @entity0 experienced a decrease in @entity4 from (mean) 1.22 to 0.9 mm (p = 0.02). SIGNIFICANCE: The Modified Atkins Diet demonstrates modest efficacy as cotherapy for some adults with pharmacoresistant @entity1 and may be also helpful for @entity2 . Financial and logistical barriers were significant factors for those who declined enrollment and for those who discontinued the study.

title: Efficacy and tolerability of the modified Atkins diet in adults with pharmacoresistant XXXX : a prospective observational study.

answer: @entity1


abstract: We have made use of isogeneic anti-idiotopic (anti-Id) monoclonal antibodies (mAb to modify experimental autoimmune @entity3 (EAMG) in Lewis @entity0 . High-avidity anti-Id mAb HC-4A (Kd = 0.1 nM) and HC-29 (Kd = 0.1 nM) were produced against an anti- @entity2 receptor (anti- @entity4 ) Lewis- @entity0 mAb 132A (Kd = 0.34 nM) that is capable of inducing passive-transfer EAMG. mAb HC-4A and HC-29 define separate framework Id cross-reactive with anti- @entity4 mAb recognizing different @entity4 epitopes. Animals were preinjected i.p. with either anti-Id mAb or with control mAb and then were actively immunized 2 wk later with purified @entity4 . All animals had elevated total serum anti- @entity4 antibody titers, despite the absence of @entity1 or decremental electromyographic findings. Animals preinjected with control mAb developed serum anti- @entity4 titers of 1.34 +/- 0.29 microM (mean +/- SEM) and reduced muscle @entity4 content to 30 percent of normal. Animals injected with 0.5 mg/kg of either anti-Id had significantly lower serum anti- @entity4 titers, 0.55 +/- 0.1, p less than 0.05, and normal muscle @entity4 content. Both the 132A Id and the anti-Id complementary to 132A were detected in the serum of all of the animals preinjected with this dose of either anti-Id HC-29 or HC-4A, whereas both were detected in a much smaller percentage of the animals receiving control mAb. These results show that pretreatment with anti-Id not only perturbs this Id-anti-Id network, but also suppresses the overall polyclonal anti- @entity4 response with resultant protection of actively immunized animals from EAMG.

title: Suppression of development of experimental autoimmune XXXX with isogeneic monoclonal anti-idiotopic antibody.

answer: @entity3


abstract: UNASSIGNED: OBJECT The association between age and outcomes following @entity6 treatment with flow diverters such as the Pipeline Embolization Device (PED) have not been well established. Using the International Retrospective Study of the Pipeline Embolization Device (IntrePED) registry, the authors assessed the age-related clinical outcomes of @entity0 undergoing @entity6 with the PED. METHODS @entity0 with @entity6 in the IntrePED registry were divided into 4 age groups:  <= 50, 51-60, 61-70, and > 70 years old. The rates of the following postoperative complications were compared between age groups using chi-square tests: spontaneous @entity4 , @entity7 ( @entity7 ), @entity3 , parent @entity8 , @entity2 , @entity1 , @entity1 , combined @entity1 and mortality, and all-cause mortality. The association between age and these complications was tested in a multivariate logistic regression analysis adjusted for sex, number of PEDs, and @entity6 size, location, and type. RESULTS Seven hundred eleven @entity0 with 820 @entity6 were included in this study. Univariate analysis demonstrated no significant difference in @entity7 rates across age groups (lowest 1.0% for @entity0  <= 50 years old and highest 5.0% for @entity0 > 70 years old, p = 0.097). There was no difference in @entity3 rates (lowest 3.6% for @entity0  <= 50 years old and highest 6.0% for @entity0 50-60 years old, p = 0.73). Age > 70 years old was associated with higher rates of @entity1 ; @entity0 > 70 years old had @entity1 rates of 7.4% compared with 3.3% for @entity0 61-70 years old, 2.7% for @entity0 51-60 years old, and 0.5% for @entity0  <= 50 years old (p = 0.006). On multivariate logistic regression analysis, increasing age was associated with higher odds of combined @entity1 and mortality (odds ratio 1.02, 95% confidence interval 1.00-1.05; p = 0.03). CONCLUSIONS Increasing age is associated with higher @entity1 and mortality after Pipeline embolization of @entity5 . However, the overall complication rates of PED treatment in this group of highly selected elderly @entity0 (> 70 years) were acceptably low, suggesting that age alone should not be considered an exclusion criterion when considering treatment of @entity5 with the PED.

title: Age-related outcomes following intracranial XXXX treatment with the Pipeline Embolization Device: a subgroup analysis of the IntrePED registry.

answer: @entity6


abstract: INTRODUCTION: @entity5 is a rare malignant cutaneous @entity2 that is locally invasive and frequently metastasizes to lymph nodes, liver, lungs, bone and brain. The incidence of @entity5 has increased in the past three decades. CASE PRESENTATION: A 65-year-old Caucasian @entity0 presented with a sudden onset of severe @entity3 and a three-month history of balance disturbance. Magnetic resonance imaging revealed a large meningeal @entity1 . The radiologic workup showed retroperitoneal and inguinal lymph node @entity1 . Biopsy of the inguinal lymph nodes showed @entity5 . Biopsy from three different suspected @entity4 revealed no @entity5 , and the primary @entity5 remained unknown. @entity1 , new axillary lymph node @entity1 , and intraspinal (epidural and intradural) @entity1 were detected within six, seven and eight months, respectively, from the start of symptoms despite treating the intracranial @entity1 with gamma knife and the abdominal @entity1 with surgical dissection and external radiotherapy. This indicates the aggressive nature of the disease. CONCLUSION: To the best of our knowledge, this is the first report in the literature of an intracranial meningeal @entity1 of @entity5 treated with gamma knife and of intraspinal intradural @entity5 . Despite good initial response to radiotherapy, recurrence and occurrence of new @entity1 are common in @entity5 .

title: Extensive central nervous system XXXX : a case report and review of the literature.

answer: @entity5


abstract: BACKGROUND: The prevalence of peanut @entity2 appears to have increased in recent decades. Other than a family history of peanut @entity2 and the presence of atopy, there are no known risk factors. METHODS: We used data from the Avon Longitudinal Study of Parents and @entity0 , a geographically defined cohort study of 13,971 preschool @entity0 , to identify those with a convincing history of peanut @entity2 and the subgroup that reacted to a double-blind peanut challenge. We first prospectively collected data on the whole cohort and then collected detailed information retrospectively by interview from the parents of @entity0 with peanut reactions and of @entity0 from two groups of controls (a random sample from the cohort and a group of @entity0 whose mothers had a history of @entity1 and who had had @entity1 themselves in the first six months of life). RESULTS: Forty-nine @entity0 had a history of peanut @entity2 ; peanut @entity2 was confirmed by peanut challenge in 23 of 36 @entity0 tested. There was no evidence of prenatal sensitization from the maternal diet, and peanut-specific IgE was not detectable in the cord blood. @entity4 was independently associated with intake of soy milk or soy formula (odds ratio, 2.6; 95 percent confidence interval, 1.3 to 5.2), @entity3 and skin creases (odds ratio, 2.6; 95 percent confidence interval, 1.4 to 5.0), and oozing, crusted @entity3 (odds ratio, 5.2; 95 percent confidence interval, 2.7 to 10.2). Analysis of interview data showed a significant independent relation of @entity4 with the use of skin preparations containing peanut oil (odds ratio, 6.8; 95 percent confidence interval, 1.4 to 32.9). CONCLUSIONS: Sensitization to peanut protein may occur in @entity0 through the application of peanut oil to inflamed skin. The association with soy protein could arise from cross-sensitization through common epitopes. Confirmation of these risk factors in future studies could lead to new strategies to prevent sensitization in @entity0 who are at risk for subsequent peanut @entity2 .

title: Factors associated with the development of XXXX in childhood.

answer: @entity4


abstract: UNASSIGNED: So far, associations between serotonergic neurotransmission pathways and suicidality have been reported. The aim of our study was to investigate the role of genetic polymorphisms and gene-gene interactions of the 5- @entity2 and the 5- @entity4 gene on suicide risk and/or a personal history of suicide attempts. A total of 374 major @entity1 @entity0 , adequately treated with antidepressants for at least 4 weeks, were collected in the context of a European multicentre study on treatment-resistant @entity1 . We assessed suicidality using the Mini International Neuropsychiatric Interview and the Hamilton Rating Scale for @entity1 (HAM-D). Treatment response was defined as HAM-D <=17 and remission as HAM-D <=7 after 4 weeks of adequate antidepressant treatment. The 5- @entity2 @entity6 ( @entity8 ) single @entity3 polymorphism (SNP) and the 5- @entity4 @entity7 , @entity5 , @entity9 and @entity10 SNPs were selected for genotyping. Using logistic regression analyses, no association (P<0.05) could be found between any SNP and neither suicide risk nor personal history of suicide attempts. Interactions between 5HTR1A @entity6 and 5HTR2A @entity5 in suicide risk, and 5 @entity2 @entity6 and 5 @entity4 @entity9 in a personal history of suicide attempts have been reported (P=0.027 and 0.036, respectively); however, the results did not survive multiple testing correction. In conclusion, our study shows no association between 5HTR1A or 5 @entity4 gene polymorphisms and both current suicide risk and personal history of suicide attempts. In addition, epistatic effects of 5HTR1A and 5 @entity4 genes on suicidal behaviour were not significant, although sample size limitations do not allow definitive conclusions.

title: The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in XXXX @entity0 with insufficient response to treatment - a European multicentre study.

answer: @entity1


abstract: UNASSIGNED: So far, associations between serotonergic neurotransmission pathways and suicidality have been reported. The aim of our study was to investigate the role of genetic polymorphisms and gene-gene interactions of the 5- @entity2 and the 5- @entity4 gene on suicide risk and/or a personal history of suicide attempts. A total of 374 major @entity1 @entity0 , adequately treated with antidepressants for at least 4 weeks, were collected in the context of a European multicentre study on treatment-resistant @entity1 . We assessed suicidality using the Mini International Neuropsychiatric Interview and the Hamilton Rating Scale for @entity1 (HAM-D). Treatment response was defined as HAM-D <=17 and remission as HAM-D <=7 after 4 weeks of adequate antidepressant treatment. The 5- @entity2 @entity6 ( @entity8 ) single @entity3 polymorphism (SNP) and the 5- @entity4 @entity7 , @entity5 , @entity9 and @entity10 SNPs were selected for genotyping. Using logistic regression analyses, no association (P<0.05) could be found between any SNP and neither suicide risk nor personal history of suicide attempts. Interactions between 5HTR1A @entity6 and 5HTR2A @entity5 in suicide risk, and 5 @entity2 @entity6 and 5 @entity4 @entity9 in a personal history of suicide attempts have been reported (P=0.027 and 0.036, respectively); however, the results did not survive multiple testing correction. In conclusion, our study shows no association between 5HTR1A or 5 @entity4 gene polymorphisms and both current suicide risk and personal history of suicide attempts. In addition, epistatic effects of 5HTR1A and 5 @entity4 genes on suicidal behaviour were not significant, although sample size limitations do not allow definitive conclusions.

title: The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in @entity1 XXXX with insufficient response to treatment - a European multicentre study.

answer: @entity0


abstract: AIM: No tools are currently available in France, for the detection of @entity3 without @entity2 (high functioning @entity3 and @entity4 here referred as TED SDI). Use of screening tests by first-line clinicians would allow better detection of @entity0 who are likely to display such difficulties and to improve @entity0 ' care. In England, 3 questionnaires have been evaluated: Autism Spectrum Quotient (AQ), Empathy Quotient (EQ), and Systemizing Quotient (SQ). This is the translation and evaluation of 3 questionnaires in France for TED SDI and control adolescents. METHODS: The translation of the questionnaires into French required two simultaneous translations, two back-translations and two consensus meetings. This is a cross-sectional study comparing scores obtained with the three AQ, EQ and SQ questionnaires. These questionnaires were completed by the parents of four groups of adolescents 11-18 years: 100 TED SDI adolescents (50 with IQ >=  85 and 50 with 70 <=IQ<85), 50 adolescents with another @entity1 (TP) and 200 control adolescents (T). RESULTS: 580 questionnaires have been sent to 40 recruiting centres. By the 28th of February, 2010, 277 completed questionnaires were received completed (TED SDI: 70 (70%); TP: 25 (50%) et T: 182 (91%)). In the control group, 92 @entity0 (mean 14.4  1.7 years) and 66 @entity0 (14.5  1.7 years) were recruited. In the TED SDI group, 4 @entity0 (14.3  2.4 years) and 42 @entity0 (14.5  1.7 years) were recruited. One @entity0 (81) and 6 @entity0 (72.2  7.7) have an IQ between 70 and 85, and 3 @entity0 (95.3  4.2) and 36 @entity0 (102.9  12) have an IQ higher than 85. In the TP group, 9 @entity0 (15.9  1.7 years) and 4 @entity0 (15.8  1.9 years) were recruited. CONCLUSION: The aim of this study is to make the AQ, EQ and SQ questionnaires available in French for French speaking clinicians. This study will allow a rigorous evaluation of the usefulness of the AQ questionnaire in the screening of TED SDI in adolescents.

title: [French version of screening questionnaire for high-functioning XXXX or @entity4 in adolescent: Autism Spectrum Quotient, Empathy Quotient and Systemizing Quotient. Protocol and questionnaire translation].

answer: @entity3


abstract: AIM: No tools are currently available in France, for the detection of @entity3 without @entity2 (high functioning @entity3 and @entity4 here referred as TED SDI). Use of screening tests by first-line clinicians would allow better detection of @entity0 who are likely to display such difficulties and to improve @entity0 ' care. In England, 3 questionnaires have been evaluated: Autism Spectrum Quotient (AQ), Empathy Quotient (EQ), and Systemizing Quotient (SQ). This is the translation and evaluation of 3 questionnaires in France for TED SDI and control adolescents. METHODS: The translation of the questionnaires into French required two simultaneous translations, two back-translations and two consensus meetings. This is a cross-sectional study comparing scores obtained with the three AQ, EQ and SQ questionnaires. These questionnaires were completed by the parents of four groups of adolescents 11-18 years: 100 TED SDI adolescents (50 with IQ >=  85 and 50 with 70 <=IQ<85), 50 adolescents with another @entity1 (TP) and 200 control adolescents (T). RESULTS: 580 questionnaires have been sent to 40 recruiting centres. By the 28th of February, 2010, 277 completed questionnaires were received completed (TED SDI: 70 (70%); TP: 25 (50%) et T: 182 (91%)). In the control group, 92 @entity0 (mean 14.4  1.7 years) and 66 @entity0 (14.5  1.7 years) were recruited. In the TED SDI group, 4 @entity0 (14.3  2.4 years) and 42 @entity0 (14.5  1.7 years) were recruited. One @entity0 (81) and 6 @entity0 (72.2  7.7) have an IQ between 70 and 85, and 3 @entity0 (95.3  4.2) and 36 @entity0 (102.9  12) have an IQ higher than 85. In the TP group, 9 @entity0 (15.9  1.7 years) and 4 @entity0 (15.8  1.9 years) were recruited. CONCLUSION: The aim of this study is to make the AQ, EQ and SQ questionnaires available in French for French speaking clinicians. This study will allow a rigorous evaluation of the usefulness of the AQ questionnaire in the screening of TED SDI in adolescents.

title: [French version of screening questionnaire for high-functioning @entity3 or XXXX in adolescent: Autism Spectrum Quotient, Empathy Quotient and Systemizing Quotient. Protocol and questionnaire translation].

answer: @entity4


abstract: BACKGROUND: @entity4 ( @entity4 ), requiring dialysis ( @entity4 -d), develops in 1-5% of @entity0 undergoing cardiac surgery and is associated with higher in-hospital mortality. Age is one of the known risk factors for the development of @entity4 . As the ageing population is increasing, the nephrologist will be faced with a large population of elderly @entity0 requiring dialysis following cardiac surgery. The aim of our study was to evaluate the influence of age on and the risk factors for in-hospital mortality. METHODS: Eighty-two @entity0 with @entity4 following cardiac surgery and requiring dialysis between January 1997 and October 2001 were included. Two groups of @entity0 were studied: the younger population (<70 years, 42 @entity0 , mean age 59+/-10) and an elderly population (>/=70 years, 40 @entity0 , mean age 76+/-4). Severity of disease was evaluated using the @entity3 ( @entity3 ), the Liano score and the SHARF (Stuivenberg Hospital Acute @entity1 ) score. RESULTS: Overall mortality in the population with @entity4 -d was 56.1%. No difference in mortality rate was found between the younger (61.9%) and elderly @entity0 group (50.0%). The two groups were very similar in baseline and procedural characteristics with exception of body weight (P=0.02) and preoperative glomerular filtration rate (P=0.0001). No significant difference was found in the scoring systems between the old and the young ( @entity3 P=0.52; Liano P=0.96; SHARF T0 P=0.06; SHARF @entity5 =0.15). Mortality in the elderly was significantly correlated with @entity2 before starting renal replacement therapy (RRT) (P=0.002), mechanical ventilation (P=0.002), presence of @entity1 ( @entity1 ) (P=0.0001) and higher scores in the severity models ( @entity3 : P=0.01; Liano: P<0.0001 and SHARF: P<0.0001). CONCLUSION: The outcome in the elderly requiring dialysis due to @entity4 post-cardiac surgery is comparable with the outcome in a younger population. No significant difference was found in severity of disease between the elderly and the younger. Variables predicting mortality in the elderly are the presence of @entity1 , mechanical ventilation and @entity2 24 h before starting RRT. These findings indicate that at the time the nephrologist is called for an elderly @entity0 requiring dialysis due to @entity4 following cardiac surgery, age per se is not a reason to withhold RRT.

title: Outcome in a post-cardiac surgery population with XXXX requiring dialysis: does age make a difference?

answer: @entity4


abstract: PURPOSE:    To evaluate retrospectively the efficiency of our rehabilitation programme for @entity0 with @entity6 . In total, 49 @entity0 were examined, 21 female and 28 male, the youngest in their late teens. @entity6 is generally characterised by @entity2 , @entity4 , and @entity7 . @entity0 are usually considerably adverse to any form of physical exercise, and despite hormonal therapy, weight control in adult @entity0 can be difficult. METHODS:    Four times a year, disease-specific residential programmes were organised, each lasting 4 weeks. The @entity0 were restricted to a 1500 Kcal diet. In addition, they were required to do 6.5   h of physical exercise daily, stamina being built up by using music therapy, psychomotor therapy, education and entertainment activities. RESULTS: BMI decreased by 2.1 average points in every residential session. For three @entity0 who attended our treatments regularly, a reduction of 8.9 points over 6 years was recorded. An attendance of at least three sessions per year seemed to be necessary to substantially reduce weight. CONCLUSIONS: A multidisciplinary approach and a daily calorie-counted diet can lead to significant @entity3 in teenage and adult @entity6 @entity0 . This approach would also be suitable in treating @entity0 with other @entity1 with @entity5 .

title: Specific treatment of XXXX through cyclical rehabilitation programmes.

answer: @entity6


abstract: Three lactating Holstein @entity1 , averaging 510 kg and fitted with T-type duodenal cannulae in the proximal duodenum, were in a 3 X 3 Latin-square experiment to measure digestion in forestomachs and whole tract of feed @entity3 and neutral detergent fiber components as influenced by frequency of feeding. @entity1 were fed one diet containing 65% chopped grass legume hay, 26% cracked @entity4 , and 8% @entity2 meal. Mixed ration was fed either once daily, four times daily, or the concentrate portion of the diet was fed once daily and the forage portion four times. Ytterbium, as @entity6 , was included with diets to allow calculation of flow rates of @entity0 . Assayed ratios of @entity3 to @entity5 in ruminal bacteria and duodenal digesta or fecal bacteria and feces were used to calculate duodenal and fecal bacterial @entity3 flows respectively. Ratios of @entity3 to @entity5 in ruminal and fecal bacteria averaged 4.15 and 2.38 g/mmol. Apparent digestibility of organic matter in the forestomachs and whole tract averaged 43.7 and 66.4%. Forestomach and whole tract digestibility of cellulose, hemicellulose, and lignin averaged 56.1, 52.0, 14.7, and 58.7, 58.5, and 16.8. Bacterial @entity3 flows averaged 255 and 91 g/day at the duodenum and in the feces. Bacterial @entity3 yield in the rumen averaged 36.6 g/kg organic matter apparently digested in the forestomachs. Frequency of feeding had no effect on almost all measures and components of rumen and whole tract metabolism and digestion. For these intakes, frequency of feeding had little effect on feed intake and nutrient utilization.

title: Forestomach and whole tract digestibility for lactating dairy XXXX as influenced by feeding frequency.

answer: @entity1


abstract: In adults untreated @entity2 ( @entity2 ) is associated with a wide variety of malignant complications. The overall mortality in @entity2 is approximately twice that of the general population. The excess @entity4 are due mainly to @entity6 . In Europe, only 26 cases of @entity2 and @entity1 in @entity0 have been published. There is evidence that @entity1 and @entity2 in @entity0 are underreported. We report a case of @entity10 in a @entity0 who developed @entity2 . As a neonate the @entity0 had been successfully operated for @entity11 . Gluten was introduced in his diet at age of 12 months. He developed @entity5 , @entity8 . Up to the age of 16 months he had lost 1500 g and @entity9 was diagnosed (IgAEMA titre 1:50 and in the duodenal biopsy specimen there was crypt hyperplastic total @entity3 ). Symptoms improved rapidly when gluten-free diet was initiated, and 4 years later, clinical and serological findings were normal. @entity10 accounts for 6% to 7% of all childhood @entity1 . There are no reports in MEDLINE about @entity2 in @entity0 who have been operated for the @entity1 . This seemed intriguing because prevalence of @entity7 calculated for Europe varies between 1/100 and 1/300.

title: [Cancer in @entity0 with celiac disease. XXXX in a @entity0 operated for @entity10 ].

answer: @entity7


abstract: In adults untreated @entity2 ( @entity2 ) is associated with a wide variety of malignant complications. The overall mortality in @entity2 is approximately twice that of the general population. The excess @entity4 are due mainly to @entity6 . In Europe, only 26 cases of @entity2 and @entity1 in @entity0 have been published. There is evidence that @entity1 and @entity2 in @entity0 are underreported. We report a case of @entity10 in a @entity0 who developed @entity2 . As a neonate the @entity0 had been successfully operated for @entity11 . Gluten was introduced in his diet at age of 12 months. He developed @entity5 , @entity8 . Up to the age of 16 months he had lost 1500 g and @entity9 was diagnosed (IgAEMA titre 1:50 and in the duodenal biopsy specimen there was crypt hyperplastic total @entity3 ). Symptoms improved rapidly when gluten-free diet was initiated, and 4 years later, clinical and serological findings were normal. @entity10 accounts for 6% to 7% of all childhood @entity1 . There are no reports in MEDLINE about @entity2 in @entity0 who have been operated for the @entity1 . This seemed intriguing because prevalence of @entity7 calculated for Europe varies between 1/100 and 1/300.

title: [Cancer in @entity0 with celiac disease. @entity7 in a @entity0 operated for XXXX ].

answer: @entity10


abstract: In adults untreated @entity2 ( @entity2 ) is associated with a wide variety of malignant complications. The overall mortality in @entity2 is approximately twice that of the general population. The excess @entity4 are due mainly to @entity6 . In Europe, only 26 cases of @entity2 and @entity1 in @entity0 have been published. There is evidence that @entity1 and @entity2 in @entity0 are underreported. We report a case of @entity10 in a @entity0 who developed @entity2 . As a neonate the @entity0 had been successfully operated for @entity11 . Gluten was introduced in his diet at age of 12 months. He developed @entity5 , @entity8 . Up to the age of 16 months he had lost 1500 g and @entity9 was diagnosed (IgAEMA titre 1:50 and in the duodenal biopsy specimen there was crypt hyperplastic total @entity3 ). Symptoms improved rapidly when gluten-free diet was initiated, and 4 years later, clinical and serological findings were normal. @entity10 accounts for 6% to 7% of all childhood @entity1 . There are no reports in MEDLINE about @entity2 in @entity0 who have been operated for the @entity1 . This seemed intriguing because prevalence of @entity7 calculated for Europe varies between 1/100 and 1/300.

title: [Cancer in XXXX with celiac disease. @entity7 in a @entity0 operated for @entity10 ].

answer: @entity0


abstract: In adults untreated @entity2 ( @entity2 ) is associated with a wide variety of malignant complications. The overall mortality in @entity2 is approximately twice that of the general population. The excess @entity4 are due mainly to @entity6 . In Europe, only 26 cases of @entity2 and @entity1 in @entity0 have been published. There is evidence that @entity1 and @entity2 in @entity0 are underreported. We report a case of @entity10 in a @entity0 who developed @entity2 . As a neonate the @entity0 had been successfully operated for @entity11 . Gluten was introduced in his diet at age of 12 months. He developed @entity5 , @entity8 . Up to the age of 16 months he had lost 1500 g and @entity9 was diagnosed (IgAEMA titre 1:50 and in the duodenal biopsy specimen there was crypt hyperplastic total @entity3 ). Symptoms improved rapidly when gluten-free diet was initiated, and 4 years later, clinical and serological findings were normal. @entity10 accounts for 6% to 7% of all childhood @entity1 . There are no reports in MEDLINE about @entity2 in @entity0 who have been operated for the @entity1 . This seemed intriguing because prevalence of @entity7 calculated for Europe varies between 1/100 and 1/300.

title: [Cancer in @entity0 with celiac disease. @entity7 in a XXXX operated for @entity10 ].

answer: @entity0


abstract: 1. The ability of the @entity0 to tolerate excess @entity3 has been investigated by subjecting @entity0 to an intravenous infusion of a 10% solution of @entity3 .2. Inulin and diodrast clearances failed to show any consistent changes in glomerular filtration rate but the effective renal plasma flow was slightly more. Plasma levels of @entity2 and @entity4 increased by 20-25% and @entity1 decreased by 30%. Urinary levels for @entity2 and @entity4 showed a corresponding increase and @entity1 excretion was reduced.3. The rates of re-absorption of @entity2 and @entity4 from the renal tubules were found to be proportional to their rates of filtration at the glomerulus, but this ratio was reduced after the hypertonic saline infusion. No such correlation could be established for @entity1 .4. Osmolar clearances indicated that continued re-absorption of osmotically free water from the kidney tubular fluid occurred during and after the hypertonic saline. Excretion of urine, hyperosmotic to plasma, was thus maintained and water conservation supported.5. Possible renal mechanisms associated with these effects are discussed.

title: The effect of an intravenous infusion of hypertonic saline on renal mechanisms and on electrolyte changes in XXXX .

answer: @entity0