abstract: BACKGROUND: The aim of this study was to compare the effectiveness of pars plana vitrectomy ( @entity6 ) and removal of the internal limiting membrane (ILM) with three, monthly, intravitreal bevacizumab (IVB) injections for refractory @entity4 . MATERIALS AND METHODS: This was a prospective, randomized, comparative, interventional study. Forty-four @entity0 were enrolled and randomized in two groups. Twenty-two eyes enrolled in Group I received three IVB injections at monthly interval. Twenty-two eyes were enrolled in Group II which underwent @entity6 with ILM removal. The primary outcomes measured were: (1) Best corrected logMAR visual acuity (BCVA) using Snellen's visual acuity chart. (2) Central macular thickness (CMT) on optical coherence tomography. The secondary outcome measures were: Complication rates like (1) progression of @entity2 , (2) high intraocular pressure needing further treatment/procedure, (3) development of @entity3 related to the procedure employed, (4) @entity5 and (5) severe @entity1 / @entity7 . RESULTS: In Group I (IVB): 3 (13.6%) eyes showed no change in BCVA; 3 (13.6%) eyes reported decrease in BCVA and 16 (72.8%) eyes showed improvement in BCVA; (P = 0.0181). In Group II ( @entity6 ): 4 (18.2%) eyes showed no change in BCVA; 5 (22.7%) eyes showed decrease and 13 (59.1%) eyes showed improvement in BCVA (P = 0.0281). Mean decrease in CMT in IVB group was 108.45  , whereas mean decrease in CMT in @entity6 group was 161.36  . No major complications were seen in either group. CONCLUSION: Posttreatment decrease in CMT was more in @entity6 group and vision improvement more in IVB group. However, no statistically significant difference between the two methods was found.

title: Pars plana vitrectomy versus three intravitreal injections of bevacizumab for nontractional XXXX . A prospective, randomized comparative study.

answer: @entity4


abstract: UNASSIGNED: A meaningful analysis in research requires robust, valid data. Paper diaries allow the collection of data from individuals over time but are notorious for poor compliance and validity. @entity1 -technology is a novel method for data collection in medical research. Time-tagged @entity1 are transferred directly to an electronic file. We used @entity1 to collect symptoms and peak flow rate (PEFR) meter readings from 32 @entity0 with @entity2 . Parents responded first to five @entity1 daily for 7 days during an asymptomatic period and then for 14 days during a cold. Compliance with use of PEFR meter and @entity1 system were assessed. Digital PEFR meters enabled data download at the end of the study to confirm validity of transmitted data. Parents of 24 @entity0 provided feedback about this data collection tool. Mean (  SD) " @entity1 -diary and PEFR-meter compliance" were 96% (  8) and 84% (  21) during baseline and 91% (  12) and 82% (  20) during cold respectively. Correctly reported PEFR values were found in 65.5% of all cases, in 8.3% PEFR values sent were "self-invented" and 2.4% of values were missing. All of the 22 parents completing the baseline questionnaire were happy to use @entity1 for this study. Of the 20 parents completing the follow up questionnaire, 95% (19/20) found the system user-friendly, 55% (11/20) would be more likely to participate in studies if they were using @entity1 data collection and 25% (5/20) were "sometimes unhappy" about receiving messages. This real-time capture of data is well accepted and could avoid some of the pitfalls of backfilled paper diaries. Pediatr Pulmonol.    2015 Wiley Periodicals, Inc.

title: The validity and acceptability of a text-based monitoring system for pediatric XXXX studies.

answer: @entity2


abstract: PURPOSE: Primary @entity3 remains a @entity1 . Gene-expression phenotypes (GEPs) in @entity2 have potential to provide clinically relevant disease stratification for improved prognosis and treatment prediction, given appropriate clinical and methodologic validation. EXPERIMENTAL DESIGN: 2,395 transcriptional @entity2 profiles were assembled from 17 public cohorts and classified by a nearest centroid @entity4 classifier into three subtypes: terminal respiratory unit (TRU), proximal-proliferative, and proximal-inflammatory, and additionally scored by five transcriptional metagenes representing different biologic processes, including proliferation. Prognostic- and chemotherapy-predictive associations of the subtypes were analyzed by univariate and multivariate analysis using overall survival or distant metastasis-free survival as endpoints. RESULTS: Overall, GEPs were associated with @entity0 outcome in both univariate and multivariate analyses, although not in all individual cohorts. The prognostically relevant division was between TRU- and non-TRU-classified cases, with expression of proliferation-associated genes as a key prognostic component. In contrast, @entity4 classification was not predictive of adjuvant chemotherapy response. @entity4 classification showed stability to random perturbations of genes or samples and alterations to classification procedures (typically <10% of cases/cohort switching subtype). High classification variability (>20% of cases switching subtype) was observed when removing larger or entire fractions of a single subtype, due to gene-centering shifts not addressable by the classifier. CONCLUSIONS: In a large-scale evaluation, we show that GEPs add prognostic value to standard clinicopathologic variables in @entity3 . Subject to classifier refinement and confirmation in prospective cohorts, GEPs have potential to affect the prognostication of @entity2 @entity0 through a molecularly driven disease stratification. Clin Cancer Res; 1-12.   2015 AACR.

title: Prognostic and Chemotherapy Predictive Value of Gene-Expression Phenotypes in Primary XXXX .

answer: @entity3


abstract: AIMS: Pre-test probability assessment is key in the approach to suspected @entity1 ( @entity1 ). However, most @entity0 with @entity3 -compatible symptoms are classified at low probability, warranting further evaluation for decision on aortic imaging. White blood cell count, platelet count and @entity2 explore pathophysiological pathways mobilized in @entity1 and are routinely assayed in the workup of @entity1 . However, the diagnostic performance of these variables for @entity1 , alone and as a bundle, is unknown. We tested the hypothesis that white blood cell count, platelet count and/or @entity2 at presentation may be applied as additional tools to standard clinical evaluation for pre-test risk assessment in @entity0 at low probability of @entity3 . METHODS AND RESULTS: This was a retrospective observational study conducted on consecutive @entity0 managed in our Emergency Department from 2009 to 2014 for suspected @entity3 . White blood cell count, platelet count and @entity2 were assayed during evaluation in the Emergency Department. The final diagnosis was obtained by computed tomography angiography. The pre-test probability of @entity3 was defined according to guidelines. Of 1210 @entity0 with suspected @entity3 , 1006 (83.1%) were classified at low probability, and 271 (22.4%) were diagnosed with @entity3 . Within @entity0 at low probability, presence of at least one alteration among white blood cell count >9*10(3)/  l, platelet count <200*10(3)/  l and @entity2 <350 mg/dl was associated with a sensitivity of 95.5% (89.7-98.5%) and a specificity of 18.3% (15.6-21.2%). In @entity0 at low probability, white blood cell count >9*10(3)/  l and platelet count <200*10(3)/  l were found as independent predictors of @entity3 beyond established clinical risk markers. Within @entity0 at low probability, the estimated risk of @entity3 based on the number of alterations amongst white blood cell count >9*10(3)/  l and platelet count <200*10(3)/  l was 2.7% (1.2-5.7%) with zero alterations, 11.3% (8.8-14.3%) with one alteration and 31.9% (24.8-40%) with two alterations (p<0.001). CONCLUSION: In addition to standard clinical evaluation, white blood cell count and platelet count may be used in @entity0 at low pre-test probability to fine-tune risk assessment of @entity3 .

title: White blood cell and platelet count as adjuncts to standard clinical evaluation for risk assessment in @entity0 at low probability of XXXX .

answer: @entity1


abstract: AIMS: Pre-test probability assessment is key in the approach to suspected @entity1 ( @entity1 ). However, most @entity0 with @entity3 -compatible symptoms are classified at low probability, warranting further evaluation for decision on aortic imaging. White blood cell count, platelet count and @entity2 explore pathophysiological pathways mobilized in @entity1 and are routinely assayed in the workup of @entity1 . However, the diagnostic performance of these variables for @entity1 , alone and as a bundle, is unknown. We tested the hypothesis that white blood cell count, platelet count and/or @entity2 at presentation may be applied as additional tools to standard clinical evaluation for pre-test risk assessment in @entity0 at low probability of @entity3 . METHODS AND RESULTS: This was a retrospective observational study conducted on consecutive @entity0 managed in our Emergency Department from 2009 to 2014 for suspected @entity3 . White blood cell count, platelet count and @entity2 were assayed during evaluation in the Emergency Department. The final diagnosis was obtained by computed tomography angiography. The pre-test probability of @entity3 was defined according to guidelines. Of 1210 @entity0 with suspected @entity3 , 1006 (83.1%) were classified at low probability, and 271 (22.4%) were diagnosed with @entity3 . Within @entity0 at low probability, presence of at least one alteration among white blood cell count >9*10(3)/  l, platelet count <200*10(3)/  l and @entity2 <350 mg/dl was associated with a sensitivity of 95.5% (89.7-98.5%) and a specificity of 18.3% (15.6-21.2%). In @entity0 at low probability, white blood cell count >9*10(3)/  l and platelet count <200*10(3)/  l were found as independent predictors of @entity3 beyond established clinical risk markers. Within @entity0 at low probability, the estimated risk of @entity3 based on the number of alterations amongst white blood cell count >9*10(3)/  l and platelet count <200*10(3)/  l was 2.7% (1.2-5.7%) with zero alterations, 11.3% (8.8-14.3%) with one alteration and 31.9% (24.8-40%) with two alterations (p<0.001). CONCLUSION: In addition to standard clinical evaluation, white blood cell count and platelet count may be used in @entity0 at low pre-test probability to fine-tune risk assessment of @entity3 .

title: White blood cell and platelet count as adjuncts to standard clinical evaluation for risk assessment in XXXX at low probability of @entity1 .

answer: @entity0


abstract: PURPOSE: Long-standing fistulizing and stenotic proctitis (LFSP) in @entity2 ( @entity2 ) indicates the end stage of the disease. Definitive diversion such as proctectomy is considered to be the only surgical option. The impact of intersphincteric sphincter-sparing anterior rectal resection (IAR) as an alternative to proctectomy is unclear. The aim of this study was to evaluate feasibility, morbidity, outcome, and quality of life (QL) in @entity0 with LFSP undergoing intended IAR. @entity0 AND METHODS: Out of a single institution database, 15 @entity0 with LFSP intended for surgery from 856 @entity0 with @entity2 were selected for follow-up analyses. RESULTS: In 12/15 cases, IAR was carried out while 3/15 @entity0 underwent primary proctectomy due to @entity1 (n   =   2) or due to @entity0 's wish (n   =   1). In one case, IAR revealed @entity1 , which led to secondary proctectomy. In @entity0 with IAR, complete healing of @entity4 and @entity5 was observed in 46  % (n   =   5) while 36  % (n   =   4) of @entity0 showed relapse of @entity4 and 18  % (n   =   2) developed @entity3 . Ileostomy closure was performed in seven @entity0 from which six @entity0 remained stoma free. QL and @entity6 measured by standardized scoring systems were unchanged while stool frequency was reduced after IAR in @entity0 with ileostomy closure. The rate of @entity1 in this cohort was 20  % (n   =   3). CONCLUSION: LFSP in @entity2 was associated with 20  % of malignant transformation. Although IAR fails to improve QL, it is a suitable procedure for the treatment of @entity4 and @entity5 associated with acceptable healing rates and can avoid a permanent stoma.

title: Sphincter-sparing intersphincteric rectal resection as an alternative to proctectomy in long-standing fistulizing and stenotic XXXX ?

answer: @entity2


abstract: AIM: The aim of the present study was to evaluate the relationship between pit and fissure sealants and the prevention of @entity1 in permanent molars of @entity0 in China. METHODS: The Cochrane Handbook for Systematic Reviews of Interventions was followed. Articles published in English and Chinese from 2002 to 2013 were selected. All these studies were randomized clinical trials related to pit and fissure sealants on caries prevention. Data were analyzed using Software Review Manager 5.1. RESULTS: A search of the four largest Chinese medical literature databases and the PubMed/Medline database yielded a total of 397 clinical research studies about the effects of pit and fissure sealants on the prevention of @entity1 ; 20 original research studies were selected. In this meta-analysis, a total of 12  187 @entity0 were included. Statistical analyses demonstrated a significant association between pit and fissure sealants and @entity1 prevention for a 6-month follow-up period (combined odds ratio  =  0.06, 95% CI: 0.01, 0.32, P  <  0.0001). For other follow ups, there was a trend in pit and fissure sealants preventing the occurrence of @entity1 . CONCLUSION: Current clinical evidence suggests that pit and fissure sealants are effective for @entity1 prevention. Sealants should be placed as part of an overall caries prevention approach. Further research with larger sample sizes and rigorously-designed clinical trials are required to corroborate the current results.

title: Systemic review of the prevention of pit and fissure caries of permanent molars by resin sealants in XXXX in China.

answer: @entity0


abstract: BACKGROUND: Ankle and hindfoot arthrodesis is often supplemented with autograft to promote bony union. Autograft harvest can lead to increased perioperative morbidity. Purified recombinant @entity0 platelet-derived growth factor BB homodimer (rhPDGF-BB) has stimulated bone formation in mandibular defects and hindfoot fusion. This randomized controlled trial evaluated the efficacy and safety of rhPDGF-BB combined with an injectable, osteoconductive @entity2 ( @entity3 )-collagen matrix versus autograft in ankle and hindfoot fusions. METHODS: Seventy-five @entity0 requiring ankle or hindfoot fusion were randomized 5:1 for rhPDGF-BB/ @entity3 -collagen (treatment, n = 63) or autograft (control, n = 12). Prospective analysis included 142 autograft control subjects from another clinical trial with identical study protocols. Standardized operative and postoperative protocols were used. @entity0 underwent standard internal fixation augmented with autograft or 0.3 mg/mL rhPDGF-BB/ @entity3 -collagen. Radiologic, clinical, and quality-of-life outcomes were assessed over 52 weeks. Primary outcome was joint fusion (50% or more osseous bridging on computed tomography) at 24 weeks. Secondary outcomes included radiographs, clinical healing status, visual analog scale @entity1 score, American Orthopaedic Foot _ Ankle Society Ankle-Hindfoot Scale score, Foot Function Index score, and Short Form-12 score. Noninferiority P values were calculated. RESULTS: Complete fusion of all involved joints at 24 weeks as indicated by computed tomography was achieved in 53 of 63 (84%) rhPDGF-BB/ @entity3 -collagen-treated @entity0 and 100 of 154 (65%) autograft-treated @entity0 (P < .001). Mean time to fusion was 14.3    8.9 weeks for rhPDGF-BB/ @entity3 -collagen @entity0 versus 19.7    11.5 weeks for autograft @entity0 (P < .01). Clinical success at 52 weeks was achieved in 57 of 63 (91%) rhPDGF-BB/ @entity3 -collagen @entity0 and 120 of 154 (78%) autograft @entity0 (P < .001). Safety-related outcomes were equivalent. Autograft controls had 2 bone graft harvest infections. CONCLUSIONS: Application of rhPDGF-BB/ @entity3 -collagen was a safe, effective alternative to autograft for ankle and hindfoot fusions, eliminating the @entity1 and morbidity associated with autograft harvesting. LEVEL OF EVIDENCE: Therapeutic Level I, prospective randomized study.

title: Prospective Randomized Controlled Trial of Hindfoot and Ankle Fusions Treated With rhPDGF-BB in Combination With a XXXX -Collagen Matrix.

answer: @entity3


abstract: BACKGROUND AND OBJECTIVES: Despite the exponential increase in the use of laparoscopic inguinal herniorrhaphy, overall recurrence rates have remained unchanged. Therefore, a growing number of @entity0 are presenting with recurrent @entity4 after conventional anterior and laparoscopic repairs have failed. This study reports our experience with @entity2 ( @entity2 ) intraperitoneal onlay mesh (IPOM) repair of these @entity4 . METHODS: @entity0 referred with two or more recurrences of @entity1 underwent @entity2 -IPOM from November 1, 2009, to June 24, 2014. A 2.5-cm infraumbilical incision was made, and an @entity2 port was placed intraperitoneally. Modified dissection techniques were used: chopstick and inline dissection, 5.5-mm/52-cm/30   angled laparoscope, and conventional straight dissecting instruments. The peritoneum was incised above the pubic symphysis, and dissection was continued laterally and proximally, raising the inferior flap below the previous extraperitoneal mesh while reducing any direct, indirect, femoral, or @entity3 before placement of antiadhesive mesh, which was fixed to the pubic ramus, as well as superiorly, with nonabsorbable tacks before the inferior border was fixed with fibrin sealant. The inferior peritoneal flap was then tacked back onto the mesh. RESULTS: Nine male @entity0 underwent @entity2 -IPOM. Their mean age was 53 years and mean body mass index was 26.8 kg/m(2). Mean mesh size was 275 cm(2). Mean operation time was 125 minutes, with a hospital stay of 1 day. The umbilical scar length was 23 mm at the 6-week follow-up. There were no intra-/postoperative complications, port-site @entity4 , @entity5 , or recurrence of the @entity4 during a mean follow-up of 24 months. CONCLUSION: @entity1 recurring after two or more failed conventional anterior and laparoscopic repairs can be safely and efficiently treated with @entity2 -IPOM.

title: Single-port onlay mesh repair of recurrent XXXX after failed anterior and laparoscopic repairs.

answer: @entity1


abstract: OBJECTIVE: @entity7 ( @entity7 ) can cause @entity4 in the assessment of ventricular function with scintigraphy even in the absence of @entity5 and @entity1 . Fragmented QRS (fQRS) is associated with various @entity2 . In this study, we aimed to determine the correlation between paradoxical septal motion and fQRS after coronary artery bypass grafting (CABG). METHODS: We retrospectively reviewed the hospital records showing scintigraphic images and electrocardiograms (ECG) of the @entity0 who had undergone CABG. The @entity0 were classified based on the evaluation of motion and thickening of the septal wall. The @entity0 with regular thickening of the septal wall and abnormal motion were classified as @entity7 (+) group. The @entity0 with normal motion and thickening of the septal wall were classified as @entity7 (-) group. fQRS complexes are defined as various RSR patterns either with or without Q-waves on a 12-lead resting ECG. RESULTS: @entity7 was found to be more common in fQRS @entity0 (p  <  0.001). @entity7 was seen in 91.4  % of cases with fQRS and in 79.8  % of cases without fQRS. No significant differences were found in the phase analysis parameters. A correlation was found between septal wall motion values and the presence of fQRS (r  =  0.197, p  =  0.012). CONCLUSION: fQRS was associated with @entity7 . fQRS may cause @entity7 in @entity0 with CABG without @entity3 due to a @entity6 . @entity7 and fQRS are predictive of cardiac mortality. @entity0 diagnosed with @entity7 and fQRS, should be monitored closely.

title: Relationship between fragmented QRS and paradoxical septal motion in coronary artery bypass graft XXXX .

answer: @entity0


abstract: UNASSIGNED: This study aimed to estimate the between- (HTP) and within- (TP) herd true prevalence distribution of @entity2 . @entity1 in dairy @entity0 herds participating in the Danish MAP control programme. All herds enrolled in the programme between 2011 and 2013 were included in the analysis, and one annual milk-ELISA test of all lactating @entity0 present in such herds was considered. A Bayesian latent class model was used to obtain HTP and TP posterior distributions for each year. The model adjusts for uncertainty in age-specific test sensitivity and prior prevalence estimates. Bayesian posterior probabilities were computed in order to compare prevalence between the years. A total of 665,700 samples were included in the study, from 221,914, 224,040, and 220,466 @entity0 sourced from 1138, 1112, and 1059 herds in years 2011, 2012, and 2013, respectively. In that period, HTP estimates of 0.92 (95% posterior probability interval (PPI), 0.87-0.96), 0.78 (95% PPI, 0.74-0.83), and 0.75 (95% PPI, 0.71-0.78) were recorded, respectively. Low TP were observed, with population mean estimates of 0.08 (95% PPI, 0.07-0.08), 0.07 (95% PPI, 0.07-0.08), and 0.07 (95% PPI, 0.06-0.07) for the three consecutive years. Statistically-important differences were recorded for HTP and population mean TP estimates between years, indicating a trend for a decreasing level of @entity3 at both herd and animal level. Model results showed that @entity3 was widespread among the Dairy @entity0 herds participating in the Danish control programme, though in general it was kept at very low levels.

title: Within- and between-herd prevalence variation of XXXX . paratuberculosis infection among control programme herds in Denmark (2011-2013).

answer: @entity2


abstract: AIMS: The @entity1 metabolic and proliferative indices in predicting @entity6 ( @entity6 ) @entity0 ' prognosis is unclear. We correlated @entity7 18 @entity2 (FDG)-positron emission tomography (PET) value and Ki67 index to @entity0 ' survival, taking into account @entity1 heterogeneity, disease characteristics and genetic aberrations. METHODS AND RESULTS: A series of 383 NSCLCs was arranged into tissue microarrays and Ki67 staining was analysed by immunohistochemistry. The maximum standardized uptake (SUV(MAX) ) value detected by @entity2 -PET analysis was calculated over a region of interest. @entity5 had higher proliferative and metabolic activities than @entity3 , and the two measures were correlated significantly. The hot-spot Ki67 value was correlated with @entity0 ' survival and the cut-off to discriminate @entity0 in the survival risk groups was 20%. Ki67 hot-spot values were greater in @entity4 kinase (ALK) rearranged @entity1 . @entity3 showed the highest intratumour heterogeneity in proliferative activity and the hot-spot Ki67 value predicted only the prognosis of @entity0 in this group. Although @entity1 metabolic activity was not associated with @entity0 ' prognosis, a SUV(MAX) > 2 was related to nodal metastases, @entity1 size and grade. CONCLUSIONS: Our results highlight how @entity1 heterogeneity influences evaluation of prognostic biomarkers. Our data support Ki67 evaluation to estimate @entity6 @entity0 ' prognosis, particularly for @entity3 .

title: Analysis of XXXX heterogeneity, proliferative and 18F-FDG PET indices reveals Ki67 prognostic role in @entity3 .

answer: @entity6


abstract: AIMS: The @entity1 metabolic and proliferative indices in predicting @entity6 ( @entity6 ) @entity0 ' prognosis is unclear. We correlated @entity7 18 @entity2 (FDG)-positron emission tomography (PET) value and Ki67 index to @entity0 ' survival, taking into account @entity1 heterogeneity, disease characteristics and genetic aberrations. METHODS AND RESULTS: A series of 383 NSCLCs was arranged into tissue microarrays and Ki67 staining was analysed by immunohistochemistry. The maximum standardized uptake (SUV(MAX) ) value detected by @entity2 -PET analysis was calculated over a region of interest. @entity5 had higher proliferative and metabolic activities than @entity3 , and the two measures were correlated significantly. The hot-spot Ki67 value was correlated with @entity0 ' survival and the cut-off to discriminate @entity0 in the survival risk groups was 20%. Ki67 hot-spot values were greater in @entity4 kinase (ALK) rearranged @entity1 . @entity3 showed the highest intratumour heterogeneity in proliferative activity and the hot-spot Ki67 value predicted only the prognosis of @entity0 in this group. Although @entity1 metabolic activity was not associated with @entity0 ' prognosis, a SUV(MAX) > 2 was related to nodal metastases, @entity1 size and grade. CONCLUSIONS: Our results highlight how @entity1 heterogeneity influences evaluation of prognostic biomarkers. Our data support Ki67 evaluation to estimate @entity6 @entity0 ' prognosis, particularly for @entity3 .

title: Analysis of @entity6 heterogeneity, proliferative and 18F-FDG PET indices reveals Ki67 prognostic role in XXXX .

answer: @entity3


abstract: AIMS: To evaluate the maintenance of efficacy and safety of insulin glargine 300 U/ml ( @entity4 -300) versus glargine 100 U/ml ( @entity4 -100) in @entity0 with @entity1 ( @entity1 ) using basal plus meal-time insulin for 12 months in the EDITION 1 trial. METHODS: EDITION 1 was a multicentre, randomized, open-label, two-arm, phase IIIa study. @entity0 completing the initial 6-month treatment period continued to receive @entity4 -300 or @entity4 -100, as previously randomized, once daily for a further 6-month open-label extension phase. Changes in glycated haemoglobin (HbA1c) and fasting plasma @entity2 concentrations, insulin dose, hypoglycaemic events and body weight were assessed. RESULTS: Of 807 @entity0 enrolled in the initial phase, 89% (359/404) assigned to @entity4 -300 and 88% (355/403) assigned to @entity4 -100 completed 12 months. Glycaemic control was sustained in both groups (mean HbA1c: @entity4 -300, 7.24%; @entity4 -100, 7.42%), with more sustained @entity3 c reduction for @entity4 -300 at 12 months: least squares mean difference @entity4 -300 vs @entity4 -100: HbA1c -0.17 [95% confidence interval (CI) -0.30 to -0.05]%. The mean daily basal insulin dose at 12 months was 1.03 U/kg for @entity4 -300 and 0.90 U/kg for @entity4 -100. Lower percentages of @entity0 had >= 1 confirmed [ <=3.9 mmol/l ( <=70 mg/dl)] or severe hypoglycaemic event with @entity4 -300 than @entity4 -100 at any time of day [24 h; 86 vs 92%; relative risk 0.94 (95% CI 0.89-0.99)] and during the night [54 vs 65%; relative risk 0.84 (95% CI 0.75-0.94)], while the annualized rates of such hypoglycaemic events were similar. No between-treatment differences in adverse events were apparent. CONCLUSION: During 12 months of treatment of @entity1 requiring basal and meal-time insulin, glycaemic control was better sustained and fewer individuals reported hypoglycaemia with @entity4 -300 than with @entity4 -100. The mean basal insulin dose was higher with @entity4 -300 compared with @entity4 -100, but total numbers of hypoglycaemic events and overall tolerability did not differ between treatments.

title: One-year sustained glycaemic control and less hypoglycaemia with new insulin glargine 300 U/ml compared with 100 U/ml in @entity0 with type 2 XXXX using basal plus meal-time insulin: the EDITION 1 12-month randomized trial, including 6-month extension.

answer: @entity1


abstract: AIMS: To evaluate the maintenance of efficacy and safety of insulin glargine 300 U/ml ( @entity4 -300) versus glargine 100 U/ml ( @entity4 -100) in @entity0 with @entity1 ( @entity1 ) using basal plus meal-time insulin for 12 months in the EDITION 1 trial. METHODS: EDITION 1 was a multicentre, randomized, open-label, two-arm, phase IIIa study. @entity0 completing the initial 6-month treatment period continued to receive @entity4 -300 or @entity4 -100, as previously randomized, once daily for a further 6-month open-label extension phase. Changes in glycated haemoglobin (HbA1c) and fasting plasma @entity2 concentrations, insulin dose, hypoglycaemic events and body weight were assessed. RESULTS: Of 807 @entity0 enrolled in the initial phase, 89% (359/404) assigned to @entity4 -300 and 88% (355/403) assigned to @entity4 -100 completed 12 months. Glycaemic control was sustained in both groups (mean HbA1c: @entity4 -300, 7.24%; @entity4 -100, 7.42%), with more sustained @entity3 c reduction for @entity4 -300 at 12 months: least squares mean difference @entity4 -300 vs @entity4 -100: HbA1c -0.17 [95% confidence interval (CI) -0.30 to -0.05]%. The mean daily basal insulin dose at 12 months was 1.03 U/kg for @entity4 -300 and 0.90 U/kg for @entity4 -100. Lower percentages of @entity0 had >= 1 confirmed [ <=3.9 mmol/l ( <=70 mg/dl)] or severe hypoglycaemic event with @entity4 -300 than @entity4 -100 at any time of day [24 h; 86 vs 92%; relative risk 0.94 (95% CI 0.89-0.99)] and during the night [54 vs 65%; relative risk 0.84 (95% CI 0.75-0.94)], while the annualized rates of such hypoglycaemic events were similar. No between-treatment differences in adverse events were apparent. CONCLUSION: During 12 months of treatment of @entity1 requiring basal and meal-time insulin, glycaemic control was better sustained and fewer individuals reported hypoglycaemia with @entity4 -300 than with @entity4 -100. The mean basal insulin dose was higher with @entity4 -300 compared with @entity4 -100, but total numbers of hypoglycaemic events and overall tolerability did not differ between treatments.

title: One-year sustained glycaemic control and less hypoglycaemia with new insulin glargine 300 U/ml compared with 100 U/ml in XXXX with type 2 @entity1 using basal plus meal-time insulin: the EDITION 1 12-month randomized trial, including 6-month extension.

answer: @entity0


abstract: @entity0 become @entity4 more frequently than @entity0 , a consistent pattern across cultures. @entity2 plays a key role in initiating @entity4 among a subset of individuals, and @entity4 also has inflammatory consequences. Notably, @entity0 experience higher levels of @entity2 and greater autoimmune disease risk compared to @entity0 . In the current review, we explore the bidirectional relationship between @entity2 and @entity4 and describe how this link may be particularly relevant for @entity0 . Compared to @entity0 , @entity0 may be more vulnerable to @entity2 -induced mood and behavior changes. For example, transient elevations in @entity2 prompt greater feelings of loneliness and social disconnection for @entity0 than for @entity0 , which can contribute to the onset of @entity4 . @entity0 also appear to be disproportionately affected by several factors that @entity2 , including prior @entity4 , somatic symptomatology, interpersonal stressors, childhood adversity, @entity1 , and physical inactivity. @entity3 and @entity1 , both of which elevate @entity4 risk, are also more strongly tied to @entity2 for @entity0 than for @entity0 . Taken together, these findings suggest that @entity0 's susceptibility to @entity2 and its mood effects may contribute to sex differences in @entity4 . @entity4 continues to be a leading cause of disability worldwide, with @entity0 experiencing greater risk than @entity0 . Due to the @entity4 connection, these patterns may promote additional health risks for @entity0 . Considering the impact of @entity2 on @entity0 's mental health may foster a better understanding of sex differences in @entity4 , as well as the selection of effective @entity4 treatments.

title: Sex Differences in XXXX : Does @entity2 Play a Role?

answer: @entity4


abstract: @entity0 become @entity4 more frequently than @entity0 , a consistent pattern across cultures. @entity2 plays a key role in initiating @entity4 among a subset of individuals, and @entity4 also has inflammatory consequences. Notably, @entity0 experience higher levels of @entity2 and greater autoimmune disease risk compared to @entity0 . In the current review, we explore the bidirectional relationship between @entity2 and @entity4 and describe how this link may be particularly relevant for @entity0 . Compared to @entity0 , @entity0 may be more vulnerable to @entity2 -induced mood and behavior changes. For example, transient elevations in @entity2 prompt greater feelings of loneliness and social disconnection for @entity0 than for @entity0 , which can contribute to the onset of @entity4 . @entity0 also appear to be disproportionately affected by several factors that @entity2 , including prior @entity4 , somatic symptomatology, interpersonal stressors, childhood adversity, @entity1 , and physical inactivity. @entity3 and @entity1 , both of which elevate @entity4 risk, are also more strongly tied to @entity2 for @entity0 than for @entity0 . Taken together, these findings suggest that @entity0 's susceptibility to @entity2 and its mood effects may contribute to sex differences in @entity4 . @entity4 continues to be a leading cause of disability worldwide, with @entity0 experiencing greater risk than @entity0 . Due to the @entity4 connection, these patterns may promote additional health risks for @entity0 . Considering the impact of @entity2 on @entity0 's mental health may foster a better understanding of sex differences in @entity4 , as well as the selection of effective @entity4 treatments.

title: Sex Differences in @entity4 : Does XXXX Play a Role?

answer: @entity2


abstract: BACKGROUND: @entity0 with medical conditions may present with @entity1 symptoms, which may lead to worse physical health care. Here we present the case of a @entity0 with @entity5 masked by @entity1 symptoms after a stressful event. CASE REPORT: A 29-year-old female medical student presented to the @entity3 ( @entity3 ) complaining about the feeling of " @entity6 " after an argument with her boyfriend earlier the same day. She did not report other symptoms or @entity2 . Careful physical examination, initially impeded by the @entity0 's agitation, revealed pulseless extremities. Blood gas analysis showed @entity4 . Transthoracic echocardiography and computed tomography ultimately led to the correct diagnosis: Stanford Type-A aortic dissection. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Medical conditions requiring acute diagnostic work-up and therapy may present with @entity1 symptoms. Increased awareness and the use of standardized operating procedures in the @entity3 may prevent fatal misdiagnoses in these @entity0 .

title: Aortic Dissection Presenting as " XXXX ".

answer: @entity6


abstract: Step-reduction (SR) in older adults results in @entity3 and an attenuated rise in postprandial muscle protein synthesis (MPS): anabolic resistance. Knowing that @entity4 ( @entity4 ) can enhance MPS, we examined whether @entity4 could enhance MPS following 2  weeks of SR. In addition, as we postulated that SR may impair feeding-induced vasodilation limiting nutrient delivery to muscle, we also examined whether @entity5 ( @entity5 ), as an @entity1 and @entity2 precursor, could attenuate muscle anabolic resistance accompanying SR. We used a unilateral leg model to compare older subjects' who had undergone SR to a loaded condition of SR plus @entity4 (SR  +  @entity4 ). Thirty older @entity0 (70      1  years) underwent 14  days of SR (<1500  steps/day) with supplementation of either 5  g/day @entity5 or @entity6 placebo. Throughout SR, subjects performed unilateral low-load @entity4 thrice weekly. We assessed muscle protein synthesis in the postabsorptive and postprandial state (20  g whey isolate plus 15  g @entity6 or as micellar-whey with 5  g @entity5 or 15  g @entity6 , n  =  10/group). As MPS was similar after ingestion of either whey isolate, micellar-whey, or micellar-whey  +  @entity5 data related to different dietary groups were collapsed to compare SR and SR  +  @entity4 legs. Subjects' daily steps were reduced by 80      2% during SR (P  <  0.001) compared with baseline. Leg fat-free mass decreased with SR (-124      61  g) and increased in the SR  +  @entity4 (+126      68  g; P  =  0.003). Myofibrillar FSR was lower (P  <  0.0001) in the SR as compared with the SR  +  @entity4 leg in the postabsorptive (0.026      0.001%/h vs. 0.045      0.001%/h) and postprandial states (0.055      0.002%/h vs. 0.115      0.003%/h). We conclude that low-load @entity4 , but not supplementation with @entity5 , can attenuate the deleterious effects of SR in aging muscle.

title: Low-load resistance training during step-reduction attenuates declines in muscle mass and strength and enhances anabolic sensitivity in older XXXX .

answer: @entity0


abstract: Cottonseed contains 16% seed oil and 23% seed protein by weight. High levels of @entity3 provides a degree of stability to the oil, while the presence of bound @entity2 in proteins considerably changes their properties, including their biological value. This study uses genetic principles to identify genomic regions associated with seed oil, protein and fibre content in @entity0 cultivars. @entity0 association mapping panel representing the US germplasm were genotyped using amplified fragment length polymorphism markers, yielding 234 polymorphic DNA fragments. Phenotypic analysis showed high genetic variability for the seed traits, seed oil range from 6.47-25.16%, protein from 1.85-28.45% and fibre content from 15.88-37.12%. There were negative correlations between seed oil and protein content.With reference to genetic diversity, the average estimate of FST was 8.852 indicating a low level of genetic differentiation among subpopulations. The AMOVA test revealed that variation was 94% within and 6% among subpopulations. Bayesian population structure identified five subpopulations and was in agreement with their geographical distribution. Among the mixed models analysed, @entity1 ( @entity1 ) identified 21 quantitative trait loci for lint percentage and seed quality traits, such as seed protein and oil. Establishing genetic diversity, population structure and marker trait associations for the seed quality traits could be valuable in understanding the genetic relationships and their utilization in breeding programmes.

title: Genetic diversity, population structure and marker trait associations for seed quality traits in XXXX ( @entity0 ).

answer: @entity0


abstract: Cottonseed contains 16% seed oil and 23% seed protein by weight. High levels of @entity3 provides a degree of stability to the oil, while the presence of bound @entity2 in proteins considerably changes their properties, including their biological value. This study uses genetic principles to identify genomic regions associated with seed oil, protein and fibre content in @entity0 cultivars. @entity0 association mapping panel representing the US germplasm were genotyped using amplified fragment length polymorphism markers, yielding 234 polymorphic DNA fragments. Phenotypic analysis showed high genetic variability for the seed traits, seed oil range from 6.47-25.16%, protein from 1.85-28.45% and fibre content from 15.88-37.12%. There were negative correlations between seed oil and protein content.With reference to genetic diversity, the average estimate of FST was 8.852 indicating a low level of genetic differentiation among subpopulations. The AMOVA test revealed that variation was 94% within and 6% among subpopulations. Bayesian population structure identified five subpopulations and was in agreement with their geographical distribution. Among the mixed models analysed, @entity1 ( @entity1 ) identified 21 quantitative trait loci for lint percentage and seed quality traits, such as seed protein and oil. Establishing genetic diversity, population structure and marker trait associations for the seed quality traits could be valuable in understanding the genetic relationships and their utilization in breeding programmes.

title: Genetic diversity, population structure and marker trait associations for seed quality traits in @entity0 ( XXXX ).

answer: @entity0


abstract: BACKGROUND: Data comparing different braces for @entity2 ( @entity2 ) are scant. The @entity4 criteria represent some guidelines for comparing results from different studies, but controlled studies are much more reliable. Recently, super-rigid braces have been introduced in clinical practice with the aim of replacing Risser and EDF casts. The aim of the present study is to compare the short-term radiographic results of two super-rigid braces, the ART and the SPORT (Sforzesco) brace. METHODS: A group of consecutive @entity0 with Cobb >40  , Risser 0-4, age >10 treated with the ART brace for 6 months were matched with a group of similar @entity0 taken from a prospective database of @entity0 treated with the Sforzesco brace. @entity0 were matched according to Cobb severity, pattern and localization of the curve. All @entity0 had a full-time brace prescription (23-24 hours per day) and an indication to perform scoliosis-specific exercises and were assessed radiographically both immediately in the brace and after 6 months of treatment out of brace. Curves were analyzed according to the pattern and localization taking into consideration both the in-brace correction and the 6-month out-of-brace results. STATISTICAL ANALYSIS: t-test, ANOVA, linear regression, alpha set at 0.05. RESULTS: Twenty-six @entity0 were included in the ART brace group, and 26 in the Sforzesco brace group. At baseline, no differences were noted for gender (3 males for each group), age (14.1        0.3 for ART vs 13.9        0.3 for Sforzesco), @entity5 (11.8        3.2 vs 11.5        4.2 for @entity1 curves and 7.8        4.0 vs 7.1        6.1 for lumbar/thoracolumbar), Cobb angle (44.8        2 vs 45.5        2 for @entity1 ; 43.8        2 vs 46.0        2 for lumbar/thoracolumbar) or Risser sign (median 2 for both groups). The in-brace correction was slightly better for the ART brace, but didn't reach statistical significance (24.3        8.5 vs 28.0        6.8 for @entity1 ; 23.7        10.4 vs 29.9        4.2 for lumbar/thoracolumbar). At 6  months, results were similar both for @entity1 (34.4        10.4 vs34.8        6.8) and for lumbar/thoracolumbar (32.8        10.8 vs 36.6        5.2). Also, with regard to the pattern, results were similar for double major and for @entity1 , while there were not enough data for single lumbar to make a comparison. No differences for @entity5 were found (7.8        3.2 vs 8.6        2.9 for @entity1 ; 4.3        3.4 vs 4.3        3.7 for lumbar/thoracolumbar). CONCLUSION: These two super-rigid braces showed similar short-term results, despite the better in-brace correction for lumbar curves shown by the ART brace. According to our data, the asymmetric design showed results similar to the symmetric one. After these preliminary data, further studies are needed to check end growth results and the impact of compliance, @entity3 of curve, exercise and assessing quality of life.

title: SOSORT Award Winner 2015: a multicentre study comparing the SPoRT and ART braces effectiveness according to the SOSORT- XXXX recommendations.

answer: @entity4


abstract: BACKGROUND: Bone marrow is a valuable source of mesenchymal stem cells (MSCs) that can be used in regenerative medicine. MSCs are able to differentiate into cells from all three germ layers under specific conditions. The aim of the current work was to study the differentiation of @entity0 MSCs (rMSCs) into neuron-like cells. NEW METHOD: We investigated how the antidepressants @entity3 , @entity4 , @entity1 and @entity5 affect the differentiation of rMSCs. Furthermore, we present differentiation cocktails using a cortex astrocyte-conditioned medium (CACM) separately or in conjunction with each of the antidepressants and investigated their additive effect on the efficiency of differentiation. We also observed how various differentiation conditions affect the number of primary @entity2 per cell. RESULTS: Gene expression for an early neuronal marker (b-III-tubulin) and markers that are typical for adult neurons such as Th, @entity6 and @entity7 were observed. The @entity8 and @entity6 gene expression were up-regulated, Th decreased slightly and @entity7 was down-regulated after differentiation We observed a two-fold higher percentage of b-III-tubulin positive cells after treatment with antidepressants and two-fold increase of neuron-like cells after using CACM with @entity3 or @entity1 simultaneously. Differentiation using @entity3 or in conjunction with CACM and @entity4 or @entity1 simultaneously increased the number of cell dendrites. COMPARISON WITH EXISTING METHODS: The results that were obtained are completely new and need further investigations in the nearest future. CONCLUSIONS: These results suggest that antidepressants improve differentiation efficiency of rMSCs and may be useful in the preparation of rMSCs for transplantation. Differentiation efficiency is higher after long-term exposure to antidepressants, than after a 24-h exposure. Nearly additive effect of CACM and @entity3 or @entity1 suggests a beneficial role of antidepressants after transplantation.

title: Affect of antidepressants on the in vitro differentiation of XXXX bone marrow mesenchymal stem cells into neuronal cells.

answer: @entity0


abstract: Purpose. To evaluate the repeatability of measurement of @entity1 ( @entity1 ) by spectral domain optical coherence (SD-OCT) in premature @entity0 and compare it to @entity1 measurement by ultrasonic pachymetry (USP). Methods. Three @entity1 measurements of the left eyes of 50 premature @entity0 were obtained by SD-OCT using the iVue system. 10 @entity1 measurements of each 28 left eyes of 28 @entity0 were obtained by USP using the Pacscan 300P system. Bland-Altman plots were developed and the limit of agreement (LoA) was determined to compare the mean of the SD-OCT and USP measurements. Results. No statistically significant difference was found among the 3 @entity1 measurements by SD-OCT. Both USP and SD-OCT have been performed for only left eyes of 28 of the 50 babies. Those results have been compared with each other. A statistically significant difference was found between the mean @entity1 measurements by SD-OCT and USP (p < 0.05). The LoA between the SD-OCT and USP measurements ranged from 11.4 to -64.1. Conclusions. @entity1 can be measured using the iVue SD-OCT system with a high level of repeatability. Although measurement of @entity1 by SD-OCT and USP is highly correlated, the 2 systems cannot be used interchangeably in premature @entity0 .

title: Comparison of Measurement of Central Corneal Thickness with Spectral Domain Optical Coherence Tomography and Standard Ultrasonic Pachymeter in Premature XXXX .

answer: @entity0


abstract: BACKGROUND: @entity6 ( @entity6 ) can arise directly from peritoneum (primary) or from regional spread of gastrointestinal and gynecological @entity1 . It is often considered a terminal event. @entity4 /HIPEC procedure provides encouraging outcomes in select sub-set of @entity0 with @entity6 . In this study we present our initial experience of this combined procedure from a tertiary @entity1 care center in India. MATERIALS AND METHODS: Between January 2014 to January 2015, 13 @entity0 underwent @entity4 + HIPEC procedure at our center. Preoperative assessment for cytoreduction was done using contrast CT-scan of the abdomen and staging laparoscopy. All procedures were performed by the same surgical team. After cytoreduction, HIPEC was performed by closed method. RESULTS: Median @entity0 age was 52 and median PCI was 13.5 (5-21). @entity2 were commonest origin of @entity6 in our series. All @entity0 had a complete cytoreduction with a median operative time of 8.3 hours. @entity3 was the commonest adverse event. In the immediate postoperative period, major complications were observed in 23% (3/13) of our @entity0 (1. @entity8 . @entity5 and liver function derangement 3. @entity7 which required a re-operation. Median hospital stay was 12 days (range 9-45 days) and there was no perioperative mortality. CONCLUSION: Our initial results indicate that @entity4 + HIPEC procedure can be performed with acceptable morbidity and no mortality. Appropriate case selection by a multi-disciplinary team is vital to achieve complete cytoreduction and optimize outcomes.

title: Preliminary Experience and Morbidity Analysis of Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy ( XXXX /HIPEC) from a Tertiary @entity1 Center in India.

answer: @entity4


abstract: BACKGROUND: @entity6 ( @entity6 ) can arise directly from peritoneum (primary) or from regional spread of gastrointestinal and gynecological @entity1 . It is often considered a terminal event. @entity4 /HIPEC procedure provides encouraging outcomes in select sub-set of @entity0 with @entity6 . In this study we present our initial experience of this combined procedure from a tertiary @entity1 care center in India. MATERIALS AND METHODS: Between January 2014 to January 2015, 13 @entity0 underwent @entity4 + HIPEC procedure at our center. Preoperative assessment for cytoreduction was done using contrast CT-scan of the abdomen and staging laparoscopy. All procedures were performed by the same surgical team. After cytoreduction, HIPEC was performed by closed method. RESULTS: Median @entity0 age was 52 and median PCI was 13.5 (5-21). @entity2 were commonest origin of @entity6 in our series. All @entity0 had a complete cytoreduction with a median operative time of 8.3 hours. @entity3 was the commonest adverse event. In the immediate postoperative period, major complications were observed in 23% (3/13) of our @entity0 (1. @entity8 . @entity5 and liver function derangement 3. @entity7 which required a re-operation. Median hospital stay was 12 days (range 9-45 days) and there was no perioperative mortality. CONCLUSION: Our initial results indicate that @entity4 + HIPEC procedure can be performed with acceptable morbidity and no mortality. Appropriate case selection by a multi-disciplinary team is vital to achieve complete cytoreduction and optimize outcomes.

title: Preliminary Experience and Morbidity Analysis of Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy ( @entity4 /HIPEC) from a Tertiary XXXX Center in India.

answer: @entity1


abstract: To test the activity and @entity2 of new @entity6 analogs, a series of Phase II disease-oriented studies were performed in @entity1 with @entity0 previously untreated with @entity3 . All drugs were administered every 3 weeks, and the doses in mg/m2 were as follows: @entity3 and @entity4 75 i.v., @entity8 35 i.v., @entity7 13 i.v. and 45 p.o. When @entity4 was tested vs @entity3 , both response rate (13 of 21 or 62% vs 11 of 21 or 52%) and median response duration (11 months vs 13 months) were comparable. In 24 @entity1 , @entity8 yielded complete plus partial response in 21% with a median duration of 15 months. In 27 @entity1 given @entity7 intravenously the response rate was 11% for 4 months and the corresponding findings when the drug was administered orally to 25 @entity1 were 24% for 8 months. Acute @entity2 manifestations were lower following treatment with all three analogs compared to @entity3 . @entity5 , as documented by echocardiography, systolic time interval and left ventricular ejection fraction was virtually absent following therapy with @entity4 and @entity7 . After a median cumulative dose of 600 mg/m2 for @entity3 -treated @entity1 there was a significant fall in LVEF compared to basal values. Similar findings were observed after a median cumulative dose of 210 mg/m2 for @entity8 . We conclude that @entity4 is as effective as @entity3 but comparatively less @entity2 when administered at the same dose schedule. At the doses and schedules utilized in this study, @entity8 and @entity7 resulted less active in @entity0 .

title: New @entity6 analogs in XXXX .

answer: @entity0


abstract: To test the activity and @entity2 of new @entity6 analogs, a series of Phase II disease-oriented studies were performed in @entity1 with @entity0 previously untreated with @entity3 . All drugs were administered every 3 weeks, and the doses in mg/m2 were as follows: @entity3 and @entity4 75 i.v., @entity8 35 i.v., @entity7 13 i.v. and 45 p.o. When @entity4 was tested vs @entity3 , both response rate (13 of 21 or 62% vs 11 of 21 or 52%) and median response duration (11 months vs 13 months) were comparable. In 24 @entity1 , @entity8 yielded complete plus partial response in 21% with a median duration of 15 months. In 27 @entity1 given @entity7 intravenously the response rate was 11% for 4 months and the corresponding findings when the drug was administered orally to 25 @entity1 were 24% for 8 months. Acute @entity2 manifestations were lower following treatment with all three analogs compared to @entity3 . @entity5 , as documented by echocardiography, systolic time interval and left ventricular ejection fraction was virtually absent following therapy with @entity4 and @entity7 . After a median cumulative dose of 600 mg/m2 for @entity3 -treated @entity1 there was a significant fall in LVEF compared to basal values. Similar findings were observed after a median cumulative dose of 210 mg/m2 for @entity8 . We conclude that @entity4 is as effective as @entity3 but comparatively less @entity2 when administered at the same dose schedule. At the doses and schedules utilized in this study, @entity8 and @entity7 resulted less active in @entity0 .

title: New XXXX analogs in @entity0 .

answer: @entity6


abstract: OBJECTIVE: Two cases of @entity1 are presented. Their diagnoses and management are discussed and contrasted. METHODS: Case report and literature review. RESULTS: @entity0 1 is a 58year old male presenting with five years of progressive @entity6 , @entity5 , and globus sensation. Clinical exam and imaging study showed a 3.5cm hypodense laryngeal mass, and he underwent transoral robotic-assisted surgery for complete excision. Final pathology revealed @entity8 . @entity0 2 is a 79year old female presenting with one year of non-progressive @entity4 . Clinical examination and imaging study revealed a 1.8cm hypodense laryngeal mass. Transoral endoscopic complete excision of the submucosal mass was performed. Final pathology revealed @entity3 . CONCLUSION: @entity7 and @entity3 may present with similar symptomatology, clinical, and imaging findings. Pathology evaluation is of utmost importance for definitive diagnosis. Therefore, diagnosis and treatment of @entity2 are best accomplished with complete excision of the mass.

title: @entity3 and XXXX : case reports and literature review.

answer: @entity7


abstract: OBJECTIVE: Two cases of @entity1 are presented. Their diagnoses and management are discussed and contrasted. METHODS: Case report and literature review. RESULTS: @entity0 1 is a 58year old male presenting with five years of progressive @entity6 , @entity5 , and globus sensation. Clinical exam and imaging study showed a 3.5cm hypodense laryngeal mass, and he underwent transoral robotic-assisted surgery for complete excision. Final pathology revealed @entity8 . @entity0 2 is a 79year old female presenting with one year of non-progressive @entity4 . Clinical examination and imaging study revealed a 1.8cm hypodense laryngeal mass. Transoral endoscopic complete excision of the submucosal mass was performed. Final pathology revealed @entity3 . CONCLUSION: @entity7 and @entity3 may present with similar symptomatology, clinical, and imaging findings. Pathology evaluation is of utmost importance for definitive diagnosis. Therefore, diagnosis and treatment of @entity2 are best accomplished with complete excision of the mass.

title: XXXX and @entity7 : case reports and literature review.

answer: @entity3


abstract: BACKGROUND: Differentiating between malignant and benign biliary lesions is critical in clinical practice but is difficult. OBJECTIVE: To systematically evaluate the diagnostic performance of single-operator peroral cholangioscopy on indeterminate biliary lesions. DESIGN: A systematic review and meta-analysis. @entity0 : @entity0 with indeterminate biliary lesions or equivocal ERCP findings. MAIN OUTCOME MEASUREMENTS: The diagnostic performance of single-operator peroral cholangioscopy on  indeterminate biliary lesions. The area under the summary receiver-operating characteristic curve was used as the main indicator for the overall diagnostic performance of single-operator peroral cholangioscopy visual  impression (VI) and SpyBite biopsy (SB). The sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were also synthesized. RESULTS: A total of 8 studies met the inclusion criteria, involving 335 @entity0 who had data on VI and 337 who had  data on SB. The area under the curve values on the summary receiver-operating characteristic curve of single-operator peroral cholangioscopy VI and SB were 0.94 (95% confidence interval [CI], 0.92-0.96) and 0.93 (95% CI,  0.90-0.95) respectively. The combined sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were 90% (95% CI, 73%-97%), 87% (95% CI, 76%-94%), 7.1 (95% CI, 3.8-13.3), 0.12 (95% CI, 0.04-0.33) for VI  and 69% (95% CI, 57%-79%), 98% (95% CI, 92%-99%), 30.1 (95% CI, 8.5-106.9), and 0.32 (95% CI, 0.23-0.44) for  SB, respectively. LIMITATIONS: Small number of included studies; comparison with ERCP could not be made. CONCLUSION: Single-operator peroral cholangioscopy is a good tool for differentiating @entity2 . VI is useful for detecting malignant lesion, whereas SB is better at confirming a malignant diagnosis, but VI is not perfect in excluding @entity1 , nor is SB, and their negative results should be interpreted with caution.

title: Is single-operator peroral cholangioscopy a useful tool for the diagnosis of indeterminate XXXX ? A systematic review and meta-analysis.

answer: @entity2


abstract: PURPOSE: To investigate the relationship between @entity1 caused by cranial nerve seven (CN VII) palsy. METHODS: A prospective case series of 60 consecutive @entity0 with unilateral @entity2 was evaluated for @entity1 . According to the House-Brackmann scale, @entity0 were divided into complete or incomplete blinking group, with the incomplete group further subdivided to early, middle or late stage according to the @entity2 duration. Schirmer's I test, tear break-up time (BUT), @entity3 , @entity4 , ability and quality of meibum expression were evaluated. Unaffected contralateral eyes were used as control for comparison. RESULTS: A paired sample t-test between affected and unaffected eyes demonstrated a significant difference for BUT, @entity3 , @entity4 , ability and quality of meibum expression in the incomplete blinking group. However, only BUT showed significant difference between affected and unaffected eyes in complete blinking group. Furthermore, we showed that @entity2 duration was related to the incidence of @entity1 . Significant difference was demonstrated between the affected and unaffected eyes for @entity3 , @entity4 , ability and quality of meibum expression in the middle and late stage, but not early stage. CONCLUSIONS: These findings suggest that the inability to blink completely induced by @entity2 for more than one week might contribute to the development of @entity1 . Clinical optimization of blinking may ameliorate @entity1 symptom and benefit @entity2 @entity0 .

title: Incomplete Blinking May Attribute to the Development of XXXX .

answer: @entity1


abstract: UNASSIGNED: Approximately 20% to 30% of @entity0 with @entity5 ( @entity5 ) have asymmetric @entity4 ( @entity4 ) and LV outflow tract obstruction (LVOTO). The role of surgical myectomy in such @entity0 is unknown. We sought to compare clinical features and outcomes of @entity0 with @entity5 and LVOTO with age- and gender-matched @entity0 with nonsyndromic, obstructive @entity3 ( @entity3 ) after myectomy. Two cohorts were selected and retrospectively analyzed using Mayo Clinic databases from 1996 to 2014. Subjects included @entity0 with @entity5 with @entity4 and LVOTO and nonsyndromic controls with obstructive @entity3 . Twenty-three @entity0 with @entity5 and @entity4 were identified, of whom 12 (8 males) underwent myectomy (10 septal and 2 combined septal/apical) for severe LVOTO (10 pediatric and 2 adults; 13    10  year old [range 1 to 39]). Similar echocardiographic improvements were noted in both groups. There were no perioperative @entity1 . Residual gradients were slightly higher in @entity0 with @entity5 . No improvement was noted in left atrial volume after myectomy in @entity0 with @entity5 . At early follow-up, the majority showed improvement in the New York Heart Association class (88% in @entity5 vs 82% in @entity3 , median of 6 and 2  months, respectively). At late follow-up (median of 7  years), the survival rate was 92% in @entity5 and 100% in @entity3 . In @entity0 with @entity5 with @entity4 and symptomatic LVOTO, myectomy reduces both gradient and the New York Heart Association class, similar to @entity0 with @entity3 . Residual gradients were slightly higher, and left @entity2 persisted in @entity0 with @entity5 . In conclusion, myectomy should be considered in @entity0 older than 1 year with @entity5 and symptomatic LVOTO.

title: Surgical Ventricular Septal Myectomy for XXXX With Noonan Syndrome and Symptomatic Left Ventricular Outflow Tract Obstruction.

answer: @entity0


abstract: UNASSIGNED: The changing landscape of health care as a result of the @entity0 Protection and Affordable Care Act (ACA) may provide new opportunities for @entity2 ( @entity2 ). The purpose of this study was to survey @entity2 in the United States on their knowledge and attitudes of the ACA and assess their perceptions of job growth under the law. A random sample of 220 (36% response rate) certified @entity2 completed a 53-item cross sectional survey administered online through Qualtrics. Findings were compared to public opinion on health care reform. @entity2 are highly favorable of the law (70%) compared to the general public (23%). A total of 85% of respondents were able to list a provision of the ACA, and most (81%) thought the ACA would be successful at increasing insured Americans. Over half (64.6%) believe job opportunities will increase. Those who viewed the law favorably were significantly more likely to score better on a knowledge scale related to the ACA. @entity2 understand publicized provisions but are uncertain about common myths and specific provisions related to Title IV, "Prevention of @entity1 and Improving Public Health." Directed and continuing education to @entity2 regarding the ACA is warranted.

title: Health Education Specialists' Knowledge, Attitudes, and Perceptions of the XXXX Protection and Affordable Care Act.

answer: @entity0


abstract: OBJECTIVES: Sudden unexplained @entity1 in @entity0 is a tragic and traumatic event, often worsened when the cause of @entity1 cannot be determined. This work aimed to investigate the presence of putative pathogenic genetic variants in a broad spectrum of @entity2 , @entity5 and @entity4 associated genes that may have increased these @entity0 's vulnerability to @entity3 . DESIGN: We performed molecular autopsy of 41 cases of sudden unexplained @entity1 in @entity0 and @entity0 through massive parallel sequencing of up to 86 @entity3 -related genes. Multiple in silico analyses were conducted together with a thorough review of the literature in order to prioritise the putative pathogenic variants. RESULTS: A total of 63 variants in 35 cases were validated. The largest proportion of these variants is located within @entity2 genes although this would have been more expected of @entity5 gene variants. Subtle microscopic features of heart tissue may indicate the presence of an early onset @entity2 as a predisposing condition to sudden unexpected @entity1 in some individuals. CONCLUSIONS: Next-generation sequencing technologies reveal the existence of a wide spectrum of rare and novel genetic variants in sarcomere genes, compared with that of cardiac ion channels, in sudden unexplained @entity1 in @entity0 and @entity0 . Our findings encourage further investigation of the role of early onset @entity2 and other diseases involving @entity2 in these deaths. Early detection of variants in these individuals could help to unmask subtle forms of disease within their relatives, who would eventually benefit from better counselling about their genetic history.

title: Broad-based molecular autopsy: a potential tool to investigate the involvement of subtle cardiac conditions in sudden unexpected XXXX in infancy and early childhood.

answer: @entity1


abstract: BACKGROUND: @entity5 affecting the aorta are a common condition associated with high mortality as a result of aortic dissection or @entity4 . Investigations of the pathogenic mechanisms involved in syndromic types of @entity9 , such as Marfan and Loeys-Dietz syndromes, have revealed an important contribution of disturbed transforming growth factor (TGF)-b signaling. OBJECTIVES: This study sought to discover a novel gene causing @entity6 in order to unravel the underlying pathogenesis. METHODS: We combined genome-wide linkage analysis, exome sequencing, and candidate gene Sanger sequencing in a total of 470 index cases with @entity9 . Extensive cardiological examination, including physical examination, electrocardiography, and transthoracic echocardiography was performed. In adults, imaging of the entire aorta using computed tomography or magnetic resonance imaging was done. RESULTS: Here, we report on 43 @entity0 from 11 families with syndromic presentations of @entity6 caused by @entity8 mutations. We demonstrate that @entity8 mutations are associated with significant @entity1 , including @entity9 , and @entity3 . Other systemic features overlap clinically with Loeys-Dietz, Shprintzen-Goldberg, and @entity7 , including @entity10 , @entity15 , skeletal overgrowth, cervical spine instability and @entity2 . In line with previous observations in aortic wall tissues of @entity0 with mutations in effectors of @entity11 signaling ( @entity14 , @entity13 , and @entity12 ), we confirm a paradoxical up-regulation of both canonical and noncanonical @entity11 signaling in association with up-regulation of the expression of @entity11 ligands. CONCLUSIONS: Our findings emphasize the broad clinical variability associated with @entity8 mutations and highlight  the  importance of early recognition of the disease because of high cardiovascular risk.

title: Mutations in a @entity11 Ligand, @entity8 , Cause  XXXX and  Dissections.

answer: @entity6


abstract: BACKGROUND: @entity5 affecting the aorta are a common condition associated with high mortality as a result of aortic dissection or @entity4 . Investigations of the pathogenic mechanisms involved in syndromic types of @entity9 , such as Marfan and Loeys-Dietz syndromes, have revealed an important contribution of disturbed transforming growth factor (TGF)-b signaling. OBJECTIVES: This study sought to discover a novel gene causing @entity6 in order to unravel the underlying pathogenesis. METHODS: We combined genome-wide linkage analysis, exome sequencing, and candidate gene Sanger sequencing in a total of 470 index cases with @entity9 . Extensive cardiological examination, including physical examination, electrocardiography, and transthoracic echocardiography was performed. In adults, imaging of the entire aorta using computed tomography or magnetic resonance imaging was done. RESULTS: Here, we report on 43 @entity0 from 11 families with syndromic presentations of @entity6 caused by @entity8 mutations. We demonstrate that @entity8 mutations are associated with significant @entity1 , including @entity9 , and @entity3 . Other systemic features overlap clinically with Loeys-Dietz, Shprintzen-Goldberg, and @entity7 , including @entity10 , @entity15 , skeletal overgrowth, cervical spine instability and @entity2 . In line with previous observations in aortic wall tissues of @entity0 with mutations in effectors of @entity11 signaling ( @entity14 , @entity13 , and @entity12 ), we confirm a paradoxical up-regulation of both canonical and noncanonical @entity11 signaling in association with up-regulation of the expression of @entity11 ligands. CONCLUSIONS: Our findings emphasize the broad clinical variability associated with @entity8 mutations and highlight  the  importance of early recognition of the disease because of high cardiovascular risk.

title: Mutations in a XXXX Ligand, @entity8 , Cause  @entity6 and  Dissections.

answer: @entity11


abstract: BACKGROUND: @entity5 affecting the aorta are a common condition associated with high mortality as a result of aortic dissection or @entity4 . Investigations of the pathogenic mechanisms involved in syndromic types of @entity9 , such as Marfan and Loeys-Dietz syndromes, have revealed an important contribution of disturbed transforming growth factor (TGF)-b signaling. OBJECTIVES: This study sought to discover a novel gene causing @entity6 in order to unravel the underlying pathogenesis. METHODS: We combined genome-wide linkage analysis, exome sequencing, and candidate gene Sanger sequencing in a total of 470 index cases with @entity9 . Extensive cardiological examination, including physical examination, electrocardiography, and transthoracic echocardiography was performed. In adults, imaging of the entire aorta using computed tomography or magnetic resonance imaging was done. RESULTS: Here, we report on 43 @entity0 from 11 families with syndromic presentations of @entity6 caused by @entity8 mutations. We demonstrate that @entity8 mutations are associated with significant @entity1 , including @entity9 , and @entity3 . Other systemic features overlap clinically with Loeys-Dietz, Shprintzen-Goldberg, and @entity7 , including @entity10 , @entity15 , skeletal overgrowth, cervical spine instability and @entity2 . In line with previous observations in aortic wall tissues of @entity0 with mutations in effectors of @entity11 signaling ( @entity14 , @entity13 , and @entity12 ), we confirm a paradoxical up-regulation of both canonical and noncanonical @entity11 signaling in association with up-regulation of the expression of @entity11 ligands. CONCLUSIONS: Our findings emphasize the broad clinical variability associated with @entity8 mutations and highlight  the  importance of early recognition of the disease because of high cardiovascular risk.

title: Mutations in a @entity11 Ligand, XXXX , Cause  @entity6 and  Dissections.

answer: @entity8


abstract: STUDY DESIGN: A retrospective study. OBJECTIVE: To evaluate the surgical outcomes of posterior @entity4 resection and short segment fusion with segmental pedicle screw fixation in @entity3 in @entity0 younger than 10 years. SUMMARY OF BACKGROUND DATA: This is the first long-term follow-up on surgical outcomes of posterior @entity4 resection and short segment fusion using segmental pedicle screw fixation in @entity0 younger than 10 years with @entity3 . METHODS: @entity0 with @entity3 (n = 18) younger than 10 years at the time of the surgery were treated by posterior @entity4 resection and bilateral pedicle screw fixation. The mean age at the time of surgery was 6.6 years (range, 2.6-9.8 yr). They were retrospectively studied with a mean follow-up of 11.4 years (range, 7.1-17.3 yr). RESULTS: The mean Cobb angle of the main curve was 34.4   before surgery, 8.6   after surgery, and 12.9   at last follow-up. In the compensatory cranial curve, the preoperative Cobb angle of 14.5   was corrected to 5.9   postoperatively and was 8.4   at last follow-up. In the compensatory caudal curve, the preoperative Cobb angle of 17.4   improved to 4   postoperatively and 6.6   at last follow-up. There were no crankshaft phenomena and no clinical and radiographical features suggestive of @entity2 during follow-up. There were no major @entity1 related to the pedicle screws. CONCLUSION: Posterior @entity4 resection after pedicle screw fixation in @entity3 is a safe and effective procedure that can achieve rigid fixation and deformity correction and restore spinal balance. This study showed that early posterior @entity4 resection of @entity3 before structural changes occur above or below can reduce fusion length, prevent curve progression, and effectively achieve a more satisfactory correction without hazardous iatrogenic @entity2 , crankshaft phenomena, or @entity1 . LEVEL OF EVIDENCE: 3.

title: Posterior Hemivertebra Resection and Short Segment Fusion With Pedicle Screw Fixation for XXXX in @entity0 Younger Than 10 Years: Greater Than 7-Year Follow-up.

answer: @entity3


abstract: STUDY DESIGN: A retrospective study. OBJECTIVE: To evaluate the surgical outcomes of posterior @entity4 resection and short segment fusion with segmental pedicle screw fixation in @entity3 in @entity0 younger than 10 years. SUMMARY OF BACKGROUND DATA: This is the first long-term follow-up on surgical outcomes of posterior @entity4 resection and short segment fusion using segmental pedicle screw fixation in @entity0 younger than 10 years with @entity3 . METHODS: @entity0 with @entity3 (n = 18) younger than 10 years at the time of the surgery were treated by posterior @entity4 resection and bilateral pedicle screw fixation. The mean age at the time of surgery was 6.6 years (range, 2.6-9.8 yr). They were retrospectively studied with a mean follow-up of 11.4 years (range, 7.1-17.3 yr). RESULTS: The mean Cobb angle of the main curve was 34.4   before surgery, 8.6   after surgery, and 12.9   at last follow-up. In the compensatory cranial curve, the preoperative Cobb angle of 14.5   was corrected to 5.9   postoperatively and was 8.4   at last follow-up. In the compensatory caudal curve, the preoperative Cobb angle of 17.4   improved to 4   postoperatively and 6.6   at last follow-up. There were no crankshaft phenomena and no clinical and radiographical features suggestive of @entity2 during follow-up. There were no major @entity1 related to the pedicle screws. CONCLUSION: Posterior @entity4 resection after pedicle screw fixation in @entity3 is a safe and effective procedure that can achieve rigid fixation and deformity correction and restore spinal balance. This study showed that early posterior @entity4 resection of @entity3 before structural changes occur above or below can reduce fusion length, prevent curve progression, and effectively achieve a more satisfactory correction without hazardous iatrogenic @entity2 , crankshaft phenomena, or @entity1 . LEVEL OF EVIDENCE: 3.

title: Posterior Hemivertebra Resection and Short Segment Fusion With Pedicle Screw Fixation for @entity3 in XXXX Younger Than 10 Years: Greater Than 7-Year Follow-up.

answer: @entity0


abstract: UNASSIGNED: @entity1 ( @entity1 ) uses heat generated by magnetic nanoparticles exposed to alternating magnetic fields to cause a temperature increase in @entity0 to the @entity1 range (43-47   C), inducing @entity0 cell death. As with all @entity0 , one of the most significant challenges with @entity1 is achieving high nanoparticle accumulation at the @entity0 site. This motivates development of synthesis strategies that maximize the rate of energy dissipation of @entity2 magnetic nanoparticles, preferable due to their intrinsic biocompatibility. This has led to development of synthesis strategies that, although attractive from the point of view of chemical elegance, may not be suitable for scale-up to quantities necessary for clinical use. On the other hand, to date the aqueous co-precipitation synthesis, which readily yields gram quantities of nanoparticles, has only been reported to yield sufficiently high specific absorption rates after laborious size selective fractionation. This work focuses on improvements to the aqueous co-precipitation of @entity2 nanoparticles to increase the specific absorption rate (SAR), by optimizing synthesis conditions and the subsequent peptization step. Heating efficiencies up to 1,048 W/gFe (36.5 kA/m, 341 kHz; @entity4 .3 nH  m(2)  kg(-1)) were obtained, which represent one of the highest values reported for @entity2 particles synthesized by co-precipitation without size-selective fractionation. Furthermore, particles reached SAR values of up to 719 W/gFe (36.5 kA/m, 341 kHz; @entity3 .6 nH  m(2)  kg(-1)) when in a solid matrix, demonstrating they were capable of significant rates of energy dissipation even when restricted from physical rotation. Reduction in energy dissipation rate due to immobilization has been identified as an obstacle to clinical translation of @entity1 . Hence, particles obtained with the conditions reported here have great potential for application in nanoscale thermal @entity0 therapy.

title: Optimization of synthesis and peptization steps to obtain XXXX nanoparticles with high energy dissipation rates.

answer: @entity2


abstract: BACKGROUND: @entity4 presents as small circumscribed ivory-like lumps on the skull vault. Although not rare, its diagnosis can be challenging for dermatologists. OBJECTIVE: To clarify the clinical characteristics of @entity4 by reviewing 10 cases. METHODS: Ten @entity0 diagnosed with @entity4 at the Department of Dermatology, Kyungpook National University Hospital, between January 2011 and August 2014 were enrolled. We retrospectively reviewed medical records and analyzed demographic and clinical characteristics including sex, age, sites, number of lesions, symptoms, duration, histopathological finding, radiological findings, and treatment. RESULTS: All @entity0 presented with an asymptomatic small circumscribed hard lump fixed to a bony structure. There were 9 female and 1 male @entity0 , and the mean age was 54 years (range, 28~61 years). The most common site was the forehead, and disease duration ranged from 2 weeks to more than 20 years. The differential diagnosis included @entity1 , @entity3 , @entity2 . Simple radiography, ultrasonography, and computed tomography (CT) were used to make a confirmative diagnosis. Histopathological findings showed lamellated bony structures with poor vascularization. Ostectomy was performed for 5 @entity0 , and no recurrence was detected within an average of 13.4 months after treatment. CONCLUSION: This review characterized @entity4 . Surgical excision is a useful therapeutic modality after CT-based diagnosis. Further studies with more @entity0 are required to confirm the findings.

title: XXXX : A Review of Ten Cases.

answer: @entity4


abstract: BACKGROUND: To address the question of how much chest-wall (CW) resections and prosthetic reconstructions influence functional outcome. METHODS: We retrospectively reviewed 175 @entity0 who underwent surgery for CW @entity1 . The clinical, histological, surgical, oncological, and functional factors were analyzed. RESULTS: We performed: 75 rib resections; 20 sternal resections; 15 combined resections; and 27 lung resections. In 39 cases (22.2%) CW was stabilized with non-rigid prosthesis (Vicryl-mesh: 8 @entity0 ; Goretex-mesh: 31 @entity0 ). @entity2 occurred in 22 cases (12.6%): a correlation with lung resection was evidenced by multivariate analysis (P = 0.025). Five-year survival for primary and secondary @entity1 was 50% and 36%, respectively: multivariate analysis (P = 0.048) showed a worse survival in @entity0 only. In the prosthesis subset, pulmonary function tested as percentage of forced expiratory volume in one second (%FEV1) (pre: 87.1    18.9%; post: 82.3    23.0%, P = ns), percentage of forced vital capacity (pre: 94.1    19.3%; post: 82.0    21.6%, P = ns), diffusing capacity of the lungs for @entity4 (pre: 15.7    7.4; post: 12.1    4.1, P = ns) and paO2 (pre: 82.6    10.9   mmHg; post: 83.9    7.3   mmHg, P = ns) was slightly modified from pre to postoperative. Interestingly, the decline of FEV1% was lower in the prosthesis-subset (4.1    15.9%) compared with the subgroup who did not undergo prosthetic stabilization (17.5    16.2%), but this difference was not statistically significant (P = ns). CONCLUSION: Because of the low decrease of lung parameters, CW prosthetic reconstruction could be helpful for avoiding postoperative worsening of functional outcome, mostly in @entity0 with pre-existing @entity3 .

title: XXXX and prosthetic reconstruction: A comparative analysis on functional outcome.

answer: @entity1


abstract: Modern warfare has caused a large number of severe @entity3 , many of which become infected. In more recent conflicts, a pattern of @entity6 with @entity9 and @entity10 -resistant @entity7 has emerged. We attempted to recreate this pattern in an animal model to evaluate the role of vascularity in contaminated @entity11 . Historically, it has been observed that infected bones frequently appear hypovascular, but vascularity in association with @entity1 has not been examined in animal models. Adult @entity0 underwent femur @entity4 and @entity2 followed by stabilization and bacterial contamination with A. baumannii complex and @entity10 -resistant @entity7 . Vascularity and perfusion were assessed by microCT angiography and SPECT scanning, respectively, at 1, 2 and 4 weeks after injury. Quantitative bacterial cultures were also obtained. Multi-bacterial @entity5 were successfully created, with @entity10 -resistant @entity7 predominating. There was overall increase in blood flow to injured limbs that was markedly greater in bacteria-inoculated limbs. Vessel volume was greater in the infected group. @entity8 was seen in both groups, but was greater in the infected group. In this animal model, @entity11 had greater perfusion and vascularity than non-infected limbs.

title: XXXX and @entity3 : a murine model.

answer: @entity11


abstract: Modern warfare has caused a large number of severe @entity3 , many of which become infected. In more recent conflicts, a pattern of @entity6 with @entity9 and @entity10 -resistant @entity7 has emerged. We attempted to recreate this pattern in an animal model to evaluate the role of vascularity in contaminated @entity11 . Historically, it has been observed that infected bones frequently appear hypovascular, but vascularity in association with @entity1 has not been examined in animal models. Adult @entity0 underwent femur @entity4 and @entity2 followed by stabilization and bacterial contamination with A. baumannii complex and @entity10 -resistant @entity7 . Vascularity and perfusion were assessed by microCT angiography and SPECT scanning, respectively, at 1, 2 and 4 weeks after injury. Quantitative bacterial cultures were also obtained. Multi-bacterial @entity5 were successfully created, with @entity10 -resistant @entity7 predominating. There was overall increase in blood flow to injured limbs that was markedly greater in bacteria-inoculated limbs. Vessel volume was greater in the infected group. @entity8 was seen in both groups, but was greater in the infected group. In this animal model, @entity11 had greater perfusion and vascularity than non-infected limbs.

title: @entity11 and XXXX : a murine model.

answer: @entity3


abstract: BACKGROUND: Lumbar spinal stenosis is a @entity1 and debilitating condition resulting in healthcare costs totaling tens of billions of dollars annually. Initial treatment consists of conservative care modalities such as physical therapy, NSAIDs, opioids, and @entity2 injections. @entity0 refractory to these therapies can undergo decompressive surgery, which has good long-term efficacy but is more traumatic and can be associated with high post-operative adverse event (AE) rates. Interspinous spacers have been developed to offer a less-invasive alternative. The objective of this study was to compare the costs and quality adjusted life years (QALYs) gained of conservative care (CC) and decompressive surgery (DS) to a new minimally-invasive interspinous spacer. METHODS: A Markov model was developed evaluating 3 strategies of care for @entity3 . If initial therapies failed, the model moved @entity0 to more invasive therapies. Data from the Superion FDA clinical trial, a prospective spinal registry, and the literature were used to populate the model. Direct medical care costs were modeled from 2014 Medicare reimbursements for healthcare services. QALYs came from the SF-12 PCS and @entity4 components. The analysis used a 2-year time horizon with a 3% discount rate. RESULTS: CC had the lowest cost at  10,540, while Spacers and DS were nearly identical at about  13,950. CC also had the lowest QALY increase (0.06), while Spacers and DS were again nearly identical (.28). The incremental cost-effectiveness ratios (ICER) for Spacers compared to CC was  16,300 and for DS was  15,200. CONCLUSIONS: Both the Spacer and DS strategies are far below the commonly cited  50,000/QALY threshold and produced several times the QALY increase versus CC, suggesting that surgical care provides superior value (cost / effectiveness) versus sustained conservative care in the treatment of @entity3 .

title: Cost-effectiveness of three treatment strategies for XXXX : Conservative care, laminectomy, and the Superion interspinous spacer.

answer: @entity3


abstract: Object. This retrospective review was conducted to determine the surgical treatment principle for @entity1 ( @entity1 ) @entity0 with @entity3 ( @entity3 ). Methods. Thirteen @entity0 with @entity3 , including 5 @entity1 @entity0 , received preoperative computed tomography- (CT-) based @entity2 ( @entity2 ) in C1 lateral mass-C2 pedicle screw-rod system fixation (LC1-PC2 fixation). These 13 @entity0 were analyzed for 52 screws inserted into C1 and C2. We defined these @entity0 as non- @entity1 group (8 @entity0 , 32 screws) and @entity1 group (5 @entity0 , 20 screws). The neurological status for @entity1 group was evaluated using the Ranawat classification. The causes of @entity3 , surgical indications, complications, surgical method revolution, and CT-based navigation application are discussed. Results. None of the 13 @entity0 expressed neurological function deterioration. The non- @entity1 group screw accuracy was 100%. In the @entity1 group, 1 @entity1 @entity0 developed left C2 screw loosening at 1(+) months after operation due to screw malposition. The screw accuracy for this group was 95%. Conclusions. Higher intraoperative surgical complication rate was described in @entity1 @entity0 . Preoperative CT-based @entity2 in LC1-PC2 fixation can provide good neurological function and screw accuracy results. However, for higher screw accuracy in @entity1 @entity0 , intraoperative CT-based @entity2 application may be considered.

title: The Surgical Treatment Principles of @entity3 Focusing on XXXX .

answer: @entity1


abstract: Object. This retrospective review was conducted to determine the surgical treatment principle for @entity1 ( @entity1 ) @entity0 with @entity3 ( @entity3 ). Methods. Thirteen @entity0 with @entity3 , including 5 @entity1 @entity0 , received preoperative computed tomography- (CT-) based @entity2 ( @entity2 ) in C1 lateral mass-C2 pedicle screw-rod system fixation (LC1-PC2 fixation). These 13 @entity0 were analyzed for 52 screws inserted into C1 and C2. We defined these @entity0 as non- @entity1 group (8 @entity0 , 32 screws) and @entity1 group (5 @entity0 , 20 screws). The neurological status for @entity1 group was evaluated using the Ranawat classification. The causes of @entity3 , surgical indications, complications, surgical method revolution, and CT-based navigation application are discussed. Results. None of the 13 @entity0 expressed neurological function deterioration. The non- @entity1 group screw accuracy was 100%. In the @entity1 group, 1 @entity1 @entity0 developed left C2 screw loosening at 1(+) months after operation due to screw malposition. The screw accuracy for this group was 95%. Conclusions. Higher intraoperative surgical complication rate was described in @entity1 @entity0 . Preoperative CT-based @entity2 in LC1-PC2 fixation can provide good neurological function and screw accuracy results. However, for higher screw accuracy in @entity1 @entity0 , intraoperative CT-based @entity2 application may be considered.

title: The Surgical Treatment Principles of XXXX Focusing on @entity1 .

answer: @entity3


abstract: INTRODUCTION: Genes that regulate the @entity6 metabolism pathways are potential targets for research in the antidepressant treatment response. This study was intended to determine whether antidepressant responses to selective @entity2 reuptake inhibitors (SSRIs) are associated with genetic polymorphisms of the @entity5 or @entity7 gene in Chinese @entity1 ( @entity1 ) @entity0 . METHODS: A total of 290 @entity1 @entity0 were recruited and received a 6-week SSRIs randomized double-blinded treatment. Allele, genotype, and haplotype frequencies were compared between responders and nonresponders in @entity6 genes. RESULTS: Genotype frequency of the @entity9 polymorphism in the @entity4 gene was significantly different between responders and nonresponders after false discovery rate correction (P   =   0.042). The frequency of the @entity4 @entity9 CG genotype was significantly higher (P   =   0.003) in responders (51.4%) than in nonresponders (35.8%), and @entity0 with the CG genotype showed an 81.7% response rate. In comparison, the response rates were 73.9% and 52.2% in @entity0 with the GG genotype and the CC genotype, respectively. The frequencies of the @entity4 @entity9 CC and GG genotypes were significantly lower (P   =   0.003) in responders (7.7%, 40.9%) than in the nonresponders (19.4%, 44.8%). No significant difference was found between two groups either in genotype or allele frequencies of single nucleotide polymorphisms in the TPH, @entity10 , @entity8 , or @entity3 genes. No significant difference was found between two groups in TPH, @entity10 , @entity8 , @entity3 , orDRD4 gene haplotypes. DISCUSSION: Polymorphisms of the @entity4 gene appear to be associated with SSRI treatment response in Chinese @entity1 @entity0 .

title: XXXX pathway polymorphisms and antidepressant response.

answer: @entity6


abstract: BACKGROUND: @entity1 ( @entity1 ) is known to be associated with the emergence of inspiratory crackles and enhanced transmission of artificial sounds from the airway opening to the chest wall. Recently, we described the effect of @entity1 on the basic flow-induced breath sounds, separated from the crackles. In this study, we investigated the effects of positive end-expiratory pressure (PEEP) on these noncrackling basic lung sounds augmented during @entity1 . METHODS: Lung sounds were recorded in six anesthetized, intubated, and mechanically ventilated @entity3 at three locations bilaterally on the chest wall. Recordings were obtained before and after induction of @entity2 with @entity5 and during application of incremental positive end-expiratory pressure. RESULTS: @entity5 injections caused severe @entity4 predominately in the dependent-lung regions. Inspiratory spectral power of breath sounds increased in all lung regions over a frequency band from 150 to 1,200 Hz, with further power augmentation in @entity0 at higher frequencies. Incremental positive end-expiratory pressure reversed the spectral power augmentation seen with @entity1 , reducing it to pre-injury levels with PEEP of 10 and 15 cmH2O in all lung regions at all frequencies. The application of positive end-expiratory pressure to normal lungs attenuated spectral power slightly and only over a band from 150 to 1,200 Hz. CONCLUSIONS: We confirm a gravity-related spectral amplitude increase of basic flow-induced breath sounds recorded over lung regions affected by permeability-type @entity4 and show that such changes are reversible by alveolar recruitment with PEEP.

title: Effect of PEEP on breath sound power spectra in experimental XXXX .

answer: @entity2


abstract: PURPOSE: To examine the effect of physical activity on the physical and psychosocial symptoms of @entity1 survivors. METHODS: A longitudinal design was used in this study. @entity0 were recruited from the chest and surgical departments of medical centers in Taiwan. The instruments used were the Godin Leisure-Time Exercise Questionnaire and the Taiwanese version of the M.D. Anderson Symptom Inventory. RESULTS: In total, 185 survivors were followed up for 6  months (response rate 66  %). Disturbed sleep was the most prevalent symptom in the @entity0 . A generalized estimating equation (GEE) method was employed to analyze the relationships among intensity of physical activity, symptom severity, and symptom interference in the daily life of the @entity0 . Regarding symptom severity, significant differences were observed in @entity2 , drowsiness, and disturbed sleep between the @entity0 who engaged in moderate physical activity and those who did not engage in any physical activity. Regarding symptom interference, the @entity0 who engaged in light physical activity experienced a significantly lower level of symptom interference than did those with a sedentary lifestyle. CONCLUSION: This is the first study to explore the role of physical activity in alleviating symptoms in @entity1 survivors by using the GEE method. The results suggest that physical activity plays an essential role in alleviating the physical and @entity1 survivors.

title: Longitudinal study on the impact of physical activity on the symptoms of XXXX survivors.

answer: @entity1


abstract: UNASSIGNED: Mosquitoes spread lethal diseases like @entity1 and @entity2 to @entity0 . Considering mosquito vector control as one of the best alternatives to reduce new infections, here we have analyzed the effect of purified pigment prodigiosin extracted from @entity5 (NMCC 75) against larval and pupal stages of @entity4 and Anopheles stephensi mosquitoes. Mosquito larvicidal activities of purified prodigiosin revealed LC50 values of 14        1.2, 15.6        1.48, 18        1.3, 21        0.87     g/ml against early IInd, IIIrd, IVth instar and pupal stages of Ae.  aegypti, respectively. LC50 values for An.  stephensi were found to be 19.7        1.12, 24.7        1.47, 26.6        1.67, 32.2        1.79     g/ml against early IInd, IIIrd, IVth instar and pupae of An.  stephensi, respectively. Further investigations toward understanding modes of action revealed variations in the activities of esterases, @entity3 esterases, phosphatases, proteases and total proteins in the fourth instar larvae of Ae.  aegypti indicating intrinsic difference in biochemical features due to @entity7 treatment. Although there was no inhibition of enzymes like catalase and oxidase but may have profound inhibitory effect on carbonic anhydrase or @entity6 -V-ATPase which is indicated by change in the pH of midgut and caeca of mosquito larvae. This reduced pH may be possibly due to the proton pump inhibitory activity of prodigiosin. Pure prodigiosin can prove to be an important molecule for mosquito control at larval and pupal stages of Ae.  aegypti and An.  stephensi. This is the first report on the mosquito pupaecidal activity of prodigiosin and its possible mechanism of action.

title: Mosquito larvicidal and pupaecidal potential of prodigiosin from XXXX and understanding its mechanism of action.

answer: @entity5


abstract: BACKGROUND: Intraoperative frozen section analysis of the surgical margins during breast-conserving surgery (BCS) for @entity0 can reliably achieve clear surgical margins and prevent re-operations. The aim of this study was to assess intraoperative entire-circumferential frozen section analysis (IEFSA) of the lumpectomy margins during BCS. METHODS: A total of 1029 @entity1 who underwent BCS with IEFSA between June 2007 and July 2013 were available for assessment. The inner surfaces of the shaved lumpectomy margins were examined as frozen sections during BCS. The margins were defined as positive when the @entity2 cells were present within 5  mm from the edge of the outermost margins of the specimens. RESULTS: Out of 1029 @entity1 , 312 @entity1 (30.3  %) had positive margins after the initial lumpectomy and underwent additional resections during BCS. Fourteen @entity1 (1.4  %) underwent mastectomy following the results of additional resections during the first surgery. Of 1015 @entity1 who completed BCS, 60 @entity1 (5.9  %) were found to have positive margins in the final pathology. One @entity1 (0.1  %) underwent re-operation after BCS while the residual diseases of the other 59 @entity1 were judged to be minimal. Of the 312 @entity1 who were judged to have positive margins after the initial lumpectomy with IEFSA, 53 @entity1 (16.9  %) were found to have negative margins in the final pathology. At a median follow-up time of 54.1  months, one @entity1 (0.1  %) had a recurrence of @entity0 in the preserved breast. CONCLUSION: IEFSA is useful for preventing the need for re-operation and local recurrence after BCS.

title: Efficacy of intraoperative entire-circumferential frozen section analysis of lumpectomy margins during breast-conserving surgery for XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity2 is farmed globally under diverse uncontrollable environments. Fish with low macroenvironmental sensitivity ( @entity1 ) of growth is important to thrive and grow under these uncontrollable environments. The @entity1 may evolve as a correlated response to selection for growth in one environment when the genetic correlation between @entity1 and growth is nonzero. The aims of this study were to quantify additive genetic variance for @entity1 of body weight (BW), defined as the slope of reaction norm across breeding environment (BE) and production environment (PE), and to estimate the genetic correlation (rg(int, sl)) between BW and @entity1 . To estimate heritable variance of @entity1 , the coheritability of @entity1 was derived using selection index theory. The BW records from 43,040 @entity2 performing either in freshwater or seawater were analysed using a reaction norm model. High additive genetic variance for @entity1 (9584) was observed, inferring that genetic changes in @entity1 can be expected. The coheritability for @entity1 was either -0.06 (intercept at PE) or -0.08 (intercept at BE), suggesting that BW observation in either PE or BE results in low accuracy of selection for @entity1 . Yet, the rg(int, sl) was negative (-0.41 to -0.33) indicating that selection for BW in one environment is expected to result in more sensitive fish. To avoid an increase of @entity1 while selecting for BW, it is possible to have equal @entity0 in BW in both environments so that @entity1 is maintained stable.

title: Genetics of Growth Reaction Norms in Farmed XXXX .

answer: @entity2