abstract: Bacteria are known to cope with environmental changes by using alternative sigma factors binding to RNA polymerase core enzyme. Sigma factor is one of the targets to modify transcription regulation in bacteria and to influence production capacities. In this study, the effect of overexpressing each annotated sigma factor gene in @entity3 WT was assayed using an @entity1 inducible plasmid system and different @entity1 concentrations. It was revealed that growth was severely decreased when sigD or sigH were overexpressed with @entity1 concentrations higher than 50  M. Overexpression of sigH led to an obvious phenotypic change, a yellow-colored supernatant. High performance liquid chromatography analysis revealed that @entity2 was excreted to the medium when sigH was overexpressed and DNA microarray analysis confirmed increased expression of @entity2 biosynthesis genes. In addition, genes for enzymes related to the @entity6 pathway and for enzymes dependent on @entity5 ( @entity5 ), @entity4 ( @entity4 ), or @entity0 as cofactor were upregulated when sigH was overexpressed. To test if sigH overexpression can be exploited for production of @entity2 -derived @entity5 or @entity4 , the endogenous gene for bifunctional @entity2 kinase/ @entity5 adenyltransferase was co-expressed with sigH from a plasmid. Balanced expression of sigH and ribF improved accumulation of @entity2 (19.8    0.3  M) and allowed for its conversion to @entity5 (33.1    1.8  M) in the supernatant. While a proof-of-concept was reached, conversion was not complete and titers were not high. This study revealed that inducible and gradable overexpression of sigma factor genes is an interesting approach to switch gene expression profiles and to discover untapped potential of bacteria for chemical production.

title: Exploring the role of sigma factor gene expression on production by @entity3 : sigma factor H and XXXX as example.

answer: @entity5


abstract: Bacteria are known to cope with environmental changes by using alternative sigma factors binding to RNA polymerase core enzyme. Sigma factor is one of the targets to modify transcription regulation in bacteria and to influence production capacities. In this study, the effect of overexpressing each annotated sigma factor gene in @entity3 WT was assayed using an @entity1 inducible plasmid system and different @entity1 concentrations. It was revealed that growth was severely decreased when sigD or sigH were overexpressed with @entity1 concentrations higher than 50  M. Overexpression of sigH led to an obvious phenotypic change, a yellow-colored supernatant. High performance liquid chromatography analysis revealed that @entity2 was excreted to the medium when sigH was overexpressed and DNA microarray analysis confirmed increased expression of @entity2 biosynthesis genes. In addition, genes for enzymes related to the @entity6 pathway and for enzymes dependent on @entity5 ( @entity5 ), @entity4 ( @entity4 ), or @entity0 as cofactor were upregulated when sigH was overexpressed. To test if sigH overexpression can be exploited for production of @entity2 -derived @entity5 or @entity4 , the endogenous gene for bifunctional @entity2 kinase/ @entity5 adenyltransferase was co-expressed with sigH from a plasmid. Balanced expression of sigH and ribF improved accumulation of @entity2 (19.8    0.3  M) and allowed for its conversion to @entity5 (33.1    1.8  M) in the supernatant. While a proof-of-concept was reached, conversion was not complete and titers were not high. This study revealed that inducible and gradable overexpression of sigma factor genes is an interesting approach to switch gene expression profiles and to discover untapped potential of bacteria for chemical production.

title: Exploring the role of sigma factor gene expression on production by XXXX : sigma factor H and @entity5 as example.

answer: @entity3


abstract: The site of outflow resistance leading to elevated intraocular pressure in primary @entity2 is believed to be located in the region of Schlemm's canal inner wall endothelium, its basement membrane and the adjacent juxtacanalicular tissue. Evidence also suggests collector channels and intrascleral vessels may have a role in intraocular pressure in both normal and @entity1 eyes. Traditional imaging modalities limit the ability to view both proximal and distal portions of the trabecular outflow pathway as a single unit. In this study, we examined the effectiveness of three-dimensional micro-computed tomography (3D micro-CT) as a potential method to view the trabecular outflow pathway. Two normal @entity0 eyes were used: one immersion fixed in 4% @entity3 and one with anterior chamber perfusion at 10  mmHg followed by perfusion fixation in 4% @entity3 /2% @entity4 . Both eyes were postfixed in 1% @entity5 and scanned with 3D micro-CT at 2   m or 5   m voxel resolution. In the immersion fixed eye, 24 collector channels were identified with an average orifice size of 27.5      5   m. In comparison, the perfusion fixed eye had 29 collector channels with a mean orifice size of 40.5      13   m. Collector channels were not evenly dispersed around the circumference of the eye. There was no significant difference in the length of Schlemm's canal in the immersed versus the perfused eye (33.2 versus 35.1  mm). Structures, locations and size measurements identified by 3D micro-CT were confirmed by correlative light microscopy. These findings confirm 3D micro-CT can be used effectively for the non-invasive examination of the trabecular meshwork, Schlemm's canal, collector channels and intrascleral vasculature that comprise the distal outflow pathway. This imaging modality will be useful for non-invasive study of the role of the trabecular outflow pathway as a whole unit.

title: Imaging the aqueous humor outflow pathway in XXXX eyes by three-dimensional micro-computed tomography (3D micro-CT).

answer: @entity0


abstract: OBJECTIVES: To identify circumstances surrounding the onset of @entity2 and common risk factors in @entity0 with @entity3 ( @entity3 ) and to suggest an alternative or complement to the pharmacologic approach by evaluating the need for a prospective study based on the impact of a targeted therapeutic education on risk management of @entity2 in this population. DESIGN: Retrospective study. SETTING: Hospital and Rehabilitation Center Setting. @entity0 : @entity0 (n=7) and @entity0 (n=25; N=32; with >= 1 @entity2 after the initial @entity3 that occurred at home or in a hospital setting; mean    SD age, 53  12y at the time of clinical review) with bone mineral density (BMD) measurements. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Demographics, main circumstances of onset, and complications of @entity2 , as well as transversal bone mineral density evaluation. RESULTS: Nine @entity0 had more than 1 @entity2 and 23 @entity0 had only 1 @entity2 (total, 43 @entity2 ; mean age at onset of @entity2 , 49  12y; median time since injury, 13.9y; mean delay in diagnosis, 6.5  15d). @entity2 occurred mostly in the lower limbs. The circumstances of onset of these @entity2 were different and very stereotyped. In 3 cases, no @entity1 was reported. The most frequent mechanisms identified were forced maneuvers by the @entity0 or a third party and falls. In 10 cases, the @entity2 occurred during a wheelchair transfer with forced maneuver or a fall from the wheelchair. Twenty-five @entity0 were confined to bed after the @entity2 (mean duration of bed confinement, 18  28d; range, 0-120d). Postfracture follow-up showed that for 43 cases of @entity2 , 19 had at least 1 orthopedic complication, 15 had local complications, and 23 had general complications. @entity0 (23 of 32) benefited from dual-energy X-ray absorptiometry to assess BMD a few months or years after the @entity2 (mean femoral neck BMD, 0.574  0.197g/cm  ; mean femoral neck T score, -3.8  1.5). CONCLUSION: With this retrospective analysis of common risk factors and circumstances of onset of secondary @entity2 , there is a clear future for a prospective study to evaluate the impact of targeted therapeutic education on risk factors for secondary @entity2 in @entity0 with @entity3 .

title: Osteoporosis in @entity0 with XXXX : the need for a targeted therapeutic education.

answer: @entity3


abstract: OBJECTIVES: To identify circumstances surrounding the onset of @entity2 and common risk factors in @entity0 with @entity3 ( @entity3 ) and to suggest an alternative or complement to the pharmacologic approach by evaluating the need for a prospective study based on the impact of a targeted therapeutic education on risk management of @entity2 in this population. DESIGN: Retrospective study. SETTING: Hospital and Rehabilitation Center Setting. @entity0 : @entity0 (n=7) and @entity0 (n=25; N=32; with >= 1 @entity2 after the initial @entity3 that occurred at home or in a hospital setting; mean    SD age, 53  12y at the time of clinical review) with bone mineral density (BMD) measurements. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Demographics, main circumstances of onset, and complications of @entity2 , as well as transversal bone mineral density evaluation. RESULTS: Nine @entity0 had more than 1 @entity2 and 23 @entity0 had only 1 @entity2 (total, 43 @entity2 ; mean age at onset of @entity2 , 49  12y; median time since injury, 13.9y; mean delay in diagnosis, 6.5  15d). @entity2 occurred mostly in the lower limbs. The circumstances of onset of these @entity2 were different and very stereotyped. In 3 cases, no @entity1 was reported. The most frequent mechanisms identified were forced maneuvers by the @entity0 or a third party and falls. In 10 cases, the @entity2 occurred during a wheelchair transfer with forced maneuver or a fall from the wheelchair. Twenty-five @entity0 were confined to bed after the @entity2 (mean duration of bed confinement, 18  28d; range, 0-120d). Postfracture follow-up showed that for 43 cases of @entity2 , 19 had at least 1 orthopedic complication, 15 had local complications, and 23 had general complications. @entity0 (23 of 32) benefited from dual-energy X-ray absorptiometry to assess BMD a few months or years after the @entity2 (mean femoral neck BMD, 0.574  0.197g/cm  ; mean femoral neck T score, -3.8  1.5). CONCLUSION: With this retrospective analysis of common risk factors and circumstances of onset of secondary @entity2 , there is a clear future for a prospective study to evaluate the impact of targeted therapeutic education on risk factors for secondary @entity2 in @entity0 with @entity3 .

title: Osteoporosis in XXXX with @entity3 : the need for a targeted therapeutic education.

answer: @entity0


abstract: BACKGROUND/OBJECTIVES: There are increasing evidences suggesting that chemotherapeutic agents can enhance the cytotoxic T lymphocytes (CTLs) antitumor effect, but the precise mechanism is not fully explained. This study aims to investigate whether @entity2 ( @entity7 ) can sensitize @entity4 cells to the CTLs antitumor response, and explore the potential mechanism. METHODS: Cell counting kit-8 assays (CCK-8) were performed to determine the @entity1 cell proliferation. Flow cytometric analysis was conducted to analyze maturation of DCs and the expression of Fas. An @entity5 FITC Apoptosis Detection Kit was performed to detect @entity1 cell apoptosis. CytoTox 96 Nonradioactive @entity3 assays were used to determine T cell-mediated @entity1 cell lysis. RESULTS: First, it was demonstrated that Bacillus Calmette Gu  rin (BCG) could be used to induce effective CTLs antitumor response. Then, @entity7 inhibited the growth of @entity0 cells, induced apoptosis and upregulated the Fas expression even at a low concentration. When antagonistic anti-Fas mAb ZB4 was preincubated with @entity7 -treated @entity0 cells, the lysis induced by CTLs was reduced. Moreover, agonistic anti-Fas mAb @entity6 induced more apoptosis of @entity7 -treated @entity0 cells. CONCLUSION: Our results show that @entity7 sensitizes @entity4 cells to the CTLs antitumor response, and the sensitization is associated with upregulation of Fas on @entity4 cells.

title: @entity2 sensitizes XXXX cells to the CTLs antitumor  response induced by BCG-stimulated dendritic cells via  a  Fas-dependent pathway.

answer: @entity4


abstract: BACKGROUND/OBJECTIVES: There are increasing evidences suggesting that chemotherapeutic agents can enhance the cytotoxic T lymphocytes (CTLs) antitumor effect, but the precise mechanism is not fully explained. This study aims to investigate whether @entity2 ( @entity7 ) can sensitize @entity4 cells to the CTLs antitumor response, and explore the potential mechanism. METHODS: Cell counting kit-8 assays (CCK-8) were performed to determine the @entity1 cell proliferation. Flow cytometric analysis was conducted to analyze maturation of DCs and the expression of Fas. An @entity5 FITC Apoptosis Detection Kit was performed to detect @entity1 cell apoptosis. CytoTox 96 Nonradioactive @entity3 assays were used to determine T cell-mediated @entity1 cell lysis. RESULTS: First, it was demonstrated that Bacillus Calmette Gu  rin (BCG) could be used to induce effective CTLs antitumor response. Then, @entity7 inhibited the growth of @entity0 cells, induced apoptosis and upregulated the Fas expression even at a low concentration. When antagonistic anti-Fas mAb ZB4 was preincubated with @entity7 -treated @entity0 cells, the lysis induced by CTLs was reduced. Moreover, agonistic anti-Fas mAb @entity6 induced more apoptosis of @entity7 -treated @entity0 cells. CONCLUSION: Our results show that @entity7 sensitizes @entity4 cells to the CTLs antitumor response, and the sensitization is associated with upregulation of Fas on @entity4 cells.

title: XXXX sensitizes @entity4 cells to the CTLs antitumor  response induced by BCG-stimulated dendritic cells via  a  Fas-dependent pathway.

answer: @entity2


abstract: MicroRNAs (miRs) are noncoding RNAs that regulate gene expression at the post-transcriptional level. In animals, the target sites of a @entity6 are generally located in the 3' untranslated regions (UTRs) of messenger RNAs. However, how the target sites change during evolution is largely unknown. @entity7 and @entity7 as are known to regulate the expression of two @entity5 genes, @entity2 and @entity3 , in @entity0 . We have therefore studied the evolutionary changes of these two @entity6 genes and their target sites of the @entity5 genes in @entity0 , other insect species, and Daphnia. Our homology search identified a single copy of each @entity6 gene located in the same genomic position of the @entity5 gene cluster in all species examined. The seed @entity1 sequence was also the same for all species. Searching for the target sites in all @entity5 genes, we found several target sites of @entity7 and @entity7 as in @entity4 in addition to @entity2 and @entity3 in most insect species examined. Our phylogenetic analysis of target sites in @entity2 , @entity3 , and @entity4 showed that the old target sites, which existed before the divergence of the 12 @entity0 species, have been well maintained in most species under purifying selection. By contrast, new target sites, which were generated during @entity0 evolution, were often lost in some species and mostly located in unalignable regions of the 3' UTRs. These results indicate that these regions can be a potential source of generating new target sites, which results in multiple target genes for each @entity6 in animals.

title: Evolutionary changes of the target sites of two microRNAs encoded in the XXXX gene cluster of @entity0 and other insect species.

answer: @entity5


abstract: MicroRNAs (miRs) are noncoding RNAs that regulate gene expression at the post-transcriptional level. In animals, the target sites of a @entity6 are generally located in the 3' untranslated regions (UTRs) of messenger RNAs. However, how the target sites change during evolution is largely unknown. @entity7 and @entity7 as are known to regulate the expression of two @entity5 genes, @entity2 and @entity3 , in @entity0 . We have therefore studied the evolutionary changes of these two @entity6 genes and their target sites of the @entity5 genes in @entity0 , other insect species, and Daphnia. Our homology search identified a single copy of each @entity6 gene located in the same genomic position of the @entity5 gene cluster in all species examined. The seed @entity1 sequence was also the same for all species. Searching for the target sites in all @entity5 genes, we found several target sites of @entity7 and @entity7 as in @entity4 in addition to @entity2 and @entity3 in most insect species examined. Our phylogenetic analysis of target sites in @entity2 , @entity3 , and @entity4 showed that the old target sites, which existed before the divergence of the 12 @entity0 species, have been well maintained in most species under purifying selection. By contrast, new target sites, which were generated during @entity0 evolution, were often lost in some species and mostly located in unalignable regions of the 3' UTRs. These results indicate that these regions can be a potential source of generating new target sites, which results in multiple target genes for each @entity6 in animals.

title: Evolutionary changes of the target sites of two microRNAs encoded in the @entity5 gene cluster of XXXX and other insect species.

answer: @entity0


abstract: PURPOSE: To compare percutaneous transpedicular vertebroplasty using @entity1 cement (CPC) versus conservative treatment for @entity6 . METHODS: Eight @entity0 and 28 @entity0 aged 61 to 99 (mean, 80) years with @entity6 underwent percutaneous transpedicular vertebroplasty using CPC. During the same period, 6 @entity0 and 32 @entity0 aged 53 to 93 (mean, 77) years underwent conservative treatment. The indication for vertebroplasty was a @entity2 , with @entity8 of the vertebral body shown on flexion and extension lateral radiographs. @entity3 without @entity8 despite deformity were treated conservatively. RESULTS: In the vertebroplasty group, all @entity0 benefited from reduced back @entity2 immediately after surgery, and @entity2 relief was maintained at the latest follow-up. However, correction loss continued until one month after the operation. The mean visual analogue score for @entity2 decreased significantly from preoperation to one day after surgery (9.3 vs. 6.2, p=0.02), and further decreased to 2.8 (p = 0.04) on day 3 or 4 when ambulation began, and to 1.5 at the one month follow-up and 1.4 at the final follow-up (mean, 14 months). The mean duration of analgesic treatment was significantly shorter in the vertebroplasty than conservatively treated group (10.2 vs. 63.5 days). All @entity0 in the vertebroplasty group achieved bone union, with no adjacent @entity3 . However, in @entity0 having conservative treatment, there were 2 adjacent @entity3 and 4 @entity5 , and the collapse continued for several months. CONCLUSION: Percutaneous transpedicular vertebroplasty using CPC achieves immediate @entity2 relief and reduces the risk of @entity4 and @entity5 among elderly @entity0 with @entity7 .

title: Percutaneous vertebroplasty for osteoporotic compression fractures using XXXX cement.

answer: @entity1


abstract: AIM: The aim of this study was to evaluate functional and prognostic benefits of Doppler ultrasonography (DU), @entity0 ( @entity0 ), and magnetic resonance urography (MRU) during diagnosis and follow-up of @entity3 ( @entity3 ) and to examine apoptosis rates caused by @entity3 in an experimental @entity1 model. METHOD: Twenty-four @entity1 were divided randomly into two groups. The left kidneys of 15 @entity1 from the first group underwent Ulm-Miller surgery to create @entity3 , whereas the left kidneys of nine @entity1 from the second group underwent sham surgery. A pressure flow study (Whitaker's test) was done during postoperative week 6. Based on the Whitaker test, the DU, @entity0 , and MRU findings were compared. The number of apoptotic renal cells was counted after death. RESULT: The Whitaker test run during postoperative week 6 revealed @entity2 in 15 @entity1 from group 1; the nine @entity1 of the sham group had no @entity2 . Sensitivity and specificity of @entity0 were 93.3 and 88.8 %, respectively, and those of MRU were 93.3 and 88.8 %, respectively. The postoperative mean RI values were significantly higher than the preoperative values, associated with sensitivity of 86.6 % and specificity of 77.5 % for detecting @entity3 . @entity0 , MRU, and RI could not predict @entity3 in one (8 %), one (8 %), and two (16 %) kidneys, respectively. Likelihood ratio (LR) was 8.4 for MRU and scintigraphy, while for RI, LR was 3.9. Pathology specimens revealed that all kidneys with @entity3 underwent apoptosis, and the number of apoptotic cells was significantly higher on the @entity3 -created side than on the contralateral and in the sham group (p < 0.05). No test predicted all apoptosis related to @entity3 . CONCLUSION: The RI, @entity0 , and DMRU results correlated with the pressure flow results for detecting @entity3 . No single radiological technique predicted all initial @entity3 -created kidneys that concluded with apoptosis. Further studies are required to seek with better methods for diagnosing an obstruction or to define a combination of radiological techniques aiding in the management decision.

title: Current radiological techniques used to evaluate unilateral partial ureteral obstruction: an experimental XXXX study.

answer: @entity1


abstract: PURPOSE: To present the management and outcomes of blebitis in @entity0 who underwent EX-PRESS @entity2 ( @entity2 ) implantation. DESIGN: Retrospective case series. @entity0 : The study included 5 @entity0 who developed blebitis following EX-PRESS @entity2 implantation. METHODS: Charts of all @entity0 who underwent EX-PRESS @entity2 implantation at the @entity2 Center of San Francisco between 2007 and 2013 were reviewed. Five @entity0 with blebitis were identified and their clinical course was recorded. MAIN OUTCOME MEASURES: Clinical course of blebitis. RESULTS: Of 325 eyes that underwent EX-PRESS @entity2 implantation, 5 eyes (1.5%) with blebitis were identified. The mean interval between EX-PRESS @entity2 surgery and blebitis was 2.3  0.8 years. Four of the 5 eyes with blebitis had potential risk factors for @entity1 ; 1 had chronic @entity5 , 2 had contact lens use, and one had 2 episodes of @entity4 before blebitis. All @entity0 were treated with topical antibiotics; in addition, 3 received oral antibiotics and 1 received intravitreal antibiotics. None of the @entity0 developed @entity3 . One @entity0 had recurrent blebitis, which was treated with topical, oral, and intravitreal antibiotics. None of the @entity0 had the device removed. The mean follow-up time after blebitis was 16.8  8.9 months (range, 10 to 32 mo). CONCLUSIONS: This case series suggests that blebitis after EX-PRESS @entity2 implanted under a scleral flap may be treated without removal of the device. Further study is required to determine the optimal method of treating this condition.

title: Blebitis After EX-PRESS XXXX Implantation-A Case Series.

answer: @entity2


abstract: BACKGROUND: @entity1 @entity0 have a significantly higher risk of developing a @entity2 ( @entity2 ) compared to non- @entity1 @entity0 and yet studies suggest @entity2 risk among @entity1 @entity0 varies widely. Recently, predictive models capable of risk-stratifying a broad range of @entity1 outpatients have been developed. Using the Khorana model a score of 2 was intermediate-high risk for @entity2 as reported by Ay and colleagues. However, validation in a broader population and methods to implement this model seamlessly into clinical practice are lacking. OBJECTIVE: To create and assess the feasibility of an innovative computerized Care Process Management System (CPMS) that would automatically access electronic medical records to calculate in real-time the risk of @entity2 in @entity0 with active @entity1 using an established @entity2 risk scoring system. METHODS: A prospective observational study of all newly referred @entity1 @entity0 at the Ottawa @entity1 care provider for 1.2 million inhabitants, was conducted. RESULTS: 699 new referrals were determined to have a @entity1 diagnosis for the first time as identified by the computer software and qualified for our study and 580 were eligible. In total 25% had intermediate-high risk for @entity2 and during the 3-month follow up period, 16 of the 143 (11%) developed a @entity2 which further validates the Khorana model for identifying intermediate-high risk @entity0 . Of the 437 @entity0 in the low risk group 19 (4%) developed a @entity2 . CONCLUSION: Newly diagnosed @entity1 @entity0 can be readily stratified into intermediate-high and low risk of @entity2 using our novel CPMS system. This innovative tool can be used to facilitate customized management decisions regarding @entity2 prophylaxis for intermediate-high risk @entity0 based their individual risk factors.

title: Implementation and validation of a risk stratification method at The Ottawa Hospital to guide thromboprophylaxis in XXXX @entity0 at intermediate-high risk for venous thrombosis.

answer: @entity1


abstract: BACKGROUND: @entity1 @entity0 have a significantly higher risk of developing a @entity2 ( @entity2 ) compared to non- @entity1 @entity0 and yet studies suggest @entity2 risk among @entity1 @entity0 varies widely. Recently, predictive models capable of risk-stratifying a broad range of @entity1 outpatients have been developed. Using the Khorana model a score of 2 was intermediate-high risk for @entity2 as reported by Ay and colleagues. However, validation in a broader population and methods to implement this model seamlessly into clinical practice are lacking. OBJECTIVE: To create and assess the feasibility of an innovative computerized Care Process Management System (CPMS) that would automatically access electronic medical records to calculate in real-time the risk of @entity2 in @entity0 with active @entity1 using an established @entity2 risk scoring system. METHODS: A prospective observational study of all newly referred @entity1 @entity0 at the Ottawa @entity1 care provider for 1.2 million inhabitants, was conducted. RESULTS: 699 new referrals were determined to have a @entity1 diagnosis for the first time as identified by the computer software and qualified for our study and 580 were eligible. In total 25% had intermediate-high risk for @entity2 and during the 3-month follow up period, 16 of the 143 (11%) developed a @entity2 which further validates the Khorana model for identifying intermediate-high risk @entity0 . Of the 437 @entity0 in the low risk group 19 (4%) developed a @entity2 . CONCLUSION: Newly diagnosed @entity1 @entity0 can be readily stratified into intermediate-high and low risk of @entity2 using our novel CPMS system. This innovative tool can be used to facilitate customized management decisions regarding @entity2 prophylaxis for intermediate-high risk @entity0 based their individual risk factors.

title: Implementation and validation of a risk stratification method at The Ottawa Hospital to guide thromboprophylaxis in @entity1 XXXX at intermediate-high risk for venous thrombosis.

answer: @entity0


abstract: UNASSIGNED: @entity8 has potent antileukemia activity and its inclusion in reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (HSCT) for acute @entity3 could potentially improve outcomes. We conducted a phase II study of @entity4 (.8 mg/kg i.v. twice daily on days  -5,  -4,  -3, and  -2) with @entity8 (40 mg/m(2) i.v. daily on days  -5,  -4,  -3, and  -2) conditioning before allogeneic 8/8 HLA-matched related or unrelated HSCT. The primary endpoint was donor neutrophil engraftment by day  +40. Secondary endpoints included nonrelapse mortality (NRM), @entity5 ( @entity5 ), progression-free survival (PFS), and @entity2 ( @entity2 ). Thirty-four @entity0 ( @entity7 [ @entity7 ], n  = 25; @entity6 , n  = 5; and @entity1 , n  = 4) were enrolled. Day 40+ engraftment with donor chimerism was achieved in 33 of 34 @entity0 with 1 @entity0 dying before count recovery. Day 100 and 1-year NRM were 5.9% (95% confidence interval [CI], 1.0 to 17.4) and 24% (95% CI, 11 to 39), respectively. The 2-year relapse rate was 26% (95% CI, 13 to 42). Cumulative incidences of acute and chronic @entity5 were 21% and 44%, respectively. The 2-year PFS was 50% (95% CI, 32 to 65) and @entity2 was 56% (95% CI, 38 to 71). For @entity0 with @entity7 in first complete remission, 2-year PFS and @entity2 were both 82% (95% CI, 55 to 94). RIC with @entity4 and @entity8 leads to successful engraftment with acceptable rates of NRM and @entity5 .

title: Phase II Trial of Reduced-Intensity XXXX / @entity8 Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation for @entity0 with @entity7 , @entity6 , and @entity1 .

answer: @entity4


abstract: UNASSIGNED: @entity8 has potent antileukemia activity and its inclusion in reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (HSCT) for acute @entity3 could potentially improve outcomes. We conducted a phase II study of @entity4 (.8 mg/kg i.v. twice daily on days  -5,  -4,  -3, and  -2) with @entity8 (40 mg/m(2) i.v. daily on days  -5,  -4,  -3, and  -2) conditioning before allogeneic 8/8 HLA-matched related or unrelated HSCT. The primary endpoint was donor neutrophil engraftment by day  +40. Secondary endpoints included nonrelapse mortality (NRM), @entity5 ( @entity5 ), progression-free survival (PFS), and @entity2 ( @entity2 ). Thirty-four @entity0 ( @entity7 [ @entity7 ], n  = 25; @entity6 , n  = 5; and @entity1 , n  = 4) were enrolled. Day 40+ engraftment with donor chimerism was achieved in 33 of 34 @entity0 with 1 @entity0 dying before count recovery. Day 100 and 1-year NRM were 5.9% (95% confidence interval [CI], 1.0 to 17.4) and 24% (95% CI, 11 to 39), respectively. The 2-year relapse rate was 26% (95% CI, 13 to 42). Cumulative incidences of acute and chronic @entity5 were 21% and 44%, respectively. The 2-year PFS was 50% (95% CI, 32 to 65) and @entity2 was 56% (95% CI, 38 to 71). For @entity0 with @entity7 in first complete remission, 2-year PFS and @entity2 were both 82% (95% CI, 55 to 94). RIC with @entity4 and @entity8 leads to successful engraftment with acceptable rates of NRM and @entity5 .

title: Phase II Trial of Reduced-Intensity @entity4 / XXXX Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation for @entity0 with @entity7 , @entity6 , and @entity1 .

answer: @entity8


abstract: UNASSIGNED: @entity8 has potent antileukemia activity and its inclusion in reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (HSCT) for acute @entity3 could potentially improve outcomes. We conducted a phase II study of @entity4 (.8 mg/kg i.v. twice daily on days  -5,  -4,  -3, and  -2) with @entity8 (40 mg/m(2) i.v. daily on days  -5,  -4,  -3, and  -2) conditioning before allogeneic 8/8 HLA-matched related or unrelated HSCT. The primary endpoint was donor neutrophil engraftment by day  +40. Secondary endpoints included nonrelapse mortality (NRM), @entity5 ( @entity5 ), progression-free survival (PFS), and @entity2 ( @entity2 ). Thirty-four @entity0 ( @entity7 [ @entity7 ], n  = 25; @entity6 , n  = 5; and @entity1 , n  = 4) were enrolled. Day 40+ engraftment with donor chimerism was achieved in 33 of 34 @entity0 with 1 @entity0 dying before count recovery. Day 100 and 1-year NRM were 5.9% (95% confidence interval [CI], 1.0 to 17.4) and 24% (95% CI, 11 to 39), respectively. The 2-year relapse rate was 26% (95% CI, 13 to 42). Cumulative incidences of acute and chronic @entity5 were 21% and 44%, respectively. The 2-year PFS was 50% (95% CI, 32 to 65) and @entity2 was 56% (95% CI, 38 to 71). For @entity0 with @entity7 in first complete remission, 2-year PFS and @entity2 were both 82% (95% CI, 55 to 94). RIC with @entity4 and @entity8 leads to successful engraftment with acceptable rates of NRM and @entity5 .

title: Phase II Trial of Reduced-Intensity @entity4 / @entity8 Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation for @entity0 with @entity7 , @entity6 , and XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity8 has potent antileukemia activity and its inclusion in reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (HSCT) for acute @entity3 could potentially improve outcomes. We conducted a phase II study of @entity4 (.8 mg/kg i.v. twice daily on days  -5,  -4,  -3, and  -2) with @entity8 (40 mg/m(2) i.v. daily on days  -5,  -4,  -3, and  -2) conditioning before allogeneic 8/8 HLA-matched related or unrelated HSCT. The primary endpoint was donor neutrophil engraftment by day  +40. Secondary endpoints included nonrelapse mortality (NRM), @entity5 ( @entity5 ), progression-free survival (PFS), and @entity2 ( @entity2 ). Thirty-four @entity0 ( @entity7 [ @entity7 ], n  = 25; @entity6 , n  = 5; and @entity1 , n  = 4) were enrolled. Day 40+ engraftment with donor chimerism was achieved in 33 of 34 @entity0 with 1 @entity0 dying before count recovery. Day 100 and 1-year NRM were 5.9% (95% confidence interval [CI], 1.0 to 17.4) and 24% (95% CI, 11 to 39), respectively. The 2-year relapse rate was 26% (95% CI, 13 to 42). Cumulative incidences of acute and chronic @entity5 were 21% and 44%, respectively. The 2-year PFS was 50% (95% CI, 32 to 65) and @entity2 was 56% (95% CI, 38 to 71). For @entity0 with @entity7 in first complete remission, 2-year PFS and @entity2 were both 82% (95% CI, 55 to 94). RIC with @entity4 and @entity8 leads to successful engraftment with acceptable rates of NRM and @entity5 .

title: Phase II Trial of Reduced-Intensity @entity4 / @entity8 Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation for @entity0 with XXXX , @entity6 , and @entity1 .

answer: @entity7


abstract: UNASSIGNED: @entity8 has potent antileukemia activity and its inclusion in reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (HSCT) for acute @entity3 could potentially improve outcomes. We conducted a phase II study of @entity4 (.8 mg/kg i.v. twice daily on days  -5,  -4,  -3, and  -2) with @entity8 (40 mg/m(2) i.v. daily on days  -5,  -4,  -3, and  -2) conditioning before allogeneic 8/8 HLA-matched related or unrelated HSCT. The primary endpoint was donor neutrophil engraftment by day  +40. Secondary endpoints included nonrelapse mortality (NRM), @entity5 ( @entity5 ), progression-free survival (PFS), and @entity2 ( @entity2 ). Thirty-four @entity0 ( @entity7 [ @entity7 ], n  = 25; @entity6 , n  = 5; and @entity1 , n  = 4) were enrolled. Day 40+ engraftment with donor chimerism was achieved in 33 of 34 @entity0 with 1 @entity0 dying before count recovery. Day 100 and 1-year NRM were 5.9% (95% confidence interval [CI], 1.0 to 17.4) and 24% (95% CI, 11 to 39), respectively. The 2-year relapse rate was 26% (95% CI, 13 to 42). Cumulative incidences of acute and chronic @entity5 were 21% and 44%, respectively. The 2-year PFS was 50% (95% CI, 32 to 65) and @entity2 was 56% (95% CI, 38 to 71). For @entity0 with @entity7 in first complete remission, 2-year PFS and @entity2 were both 82% (95% CI, 55 to 94). RIC with @entity4 and @entity8 leads to successful engraftment with acceptable rates of NRM and @entity5 .

title: Phase II Trial of Reduced-Intensity @entity4 / @entity8 Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation for @entity0 with @entity7 , XXXX , and @entity1 .

answer: @entity6


abstract: UNASSIGNED: @entity8 has potent antileukemia activity and its inclusion in reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (HSCT) for acute @entity3 could potentially improve outcomes. We conducted a phase II study of @entity4 (.8 mg/kg i.v. twice daily on days  -5,  -4,  -3, and  -2) with @entity8 (40 mg/m(2) i.v. daily on days  -5,  -4,  -3, and  -2) conditioning before allogeneic 8/8 HLA-matched related or unrelated HSCT. The primary endpoint was donor neutrophil engraftment by day  +40. Secondary endpoints included nonrelapse mortality (NRM), @entity5 ( @entity5 ), progression-free survival (PFS), and @entity2 ( @entity2 ). Thirty-four @entity0 ( @entity7 [ @entity7 ], n  = 25; @entity6 , n  = 5; and @entity1 , n  = 4) were enrolled. Day 40+ engraftment with donor chimerism was achieved in 33 of 34 @entity0 with 1 @entity0 dying before count recovery. Day 100 and 1-year NRM were 5.9% (95% confidence interval [CI], 1.0 to 17.4) and 24% (95% CI, 11 to 39), respectively. The 2-year relapse rate was 26% (95% CI, 13 to 42). Cumulative incidences of acute and chronic @entity5 were 21% and 44%, respectively. The 2-year PFS was 50% (95% CI, 32 to 65) and @entity2 was 56% (95% CI, 38 to 71). For @entity0 with @entity7 in first complete remission, 2-year PFS and @entity2 were both 82% (95% CI, 55 to 94). RIC with @entity4 and @entity8 leads to successful engraftment with acceptable rates of NRM and @entity5 .

title: Phase II Trial of Reduced-Intensity @entity4 / @entity8 Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation for XXXX with @entity7 , @entity6 , and @entity1 .

answer: @entity0


abstract: UNASSIGNED: @entity1 ( @entity1 ) is an endemic type of @entity2 with a high rate of cervical lymph node @entity0 . An increasing number of studies have shown that microRNAs (miRNAs) play a key role in the development and progression of @entity1 . miR-338-3p has been demonstrated as an anti-oncogene in different @entity1 . The aim of the present study was to investigate the potential role of miR  -338-3p in the development and progression of @entity1 . Compared with normal samples, our data showed that miR-338-3p were downregulated in @entity1 tissues and cells. The luciferase assay demonstrated that @entity5 was a direct target of miR-338-3p. We also found that miR-338-3p regulated the expression levels of @entity5 , respectively. Overexpression of miR-338-3p in @entity1 cells significantly inhibited cell proliferation, and migration. Conversely, miR-338-3p knockdown in cells with lower endogenous expression levels significantly reduced antitumor behavior. Furthermore, enforced expression of miR-338-3p led to a decline in ERK phosphorylation as well as inhibited the @entity3 induced epithelial to mesenchymal transition. Cells pre-transfected with miR-338-3p can overcome @entity3 -mediated @entity4 resistance. Taken together, we found that miR-338-3p directly targeted @entity5 , and we provide insight into @entity1 initiation and progression, possibly representing a novel therapeutic target.

title: MicroRNA-338 inhibits migration and proliferation by targeting XXXX -induced factor 1a in nasopharyngeal carcinoma.

answer: @entity3


abstract: BACKGROUND: Distinguishing stable supination-external rotation (SER) 2 from unstable SER 4 @entity2 , using standard radiographs, is controversial. Examination under anaesthesia (EUA), @entity3 ( @entity3 ) and weight-bearing (WB) radiographs can aid surgical decision-making. We evaluated the effect of three methods of fracture stability assessment. METHODS: Radiographs and case-notes of 312 consecutive @entity0 with @entity4 /4 fractures were reviewed. We recorded ankle stability assessment (plain film (PF) and EUA vs. @entity3 vs. WB radiographs), management (conservative vs. operative), unplanned surgery and complications. RESULTS: Forty five percent assessed with @entity3 underwent surgery (6% for PF/EUA, 4% for WB; P=0.0001). Amongst @entity3 @entity0 , 11% underwent additional surgery (0.1% PF/EUA, 0% WB; P=0.0001). Complications occurred in 2% of the WB group (8% for PF/EUA, 22% for @entity3 ; P=0.007). CONCLUSION: This study associates @entity3 assessment with higher rates of surgery and complications. Subsequent studies may determine the longer term effect stability assessments have on post-traumatic @entity1 .

title: The effect of different methods of stability assessment on fixation rate and complications in supination external rotation (SER) 2/4 XXXX .

answer: @entity2


abstract: PURPOSE: Acupuncture has been used as a complementary medical treatment for @entity5 and other types of @entity3 . The objective of this review is to assess the effectiveness of acupuncture in the treatment of @entity5 in @entity1 with @entity0 who were treated with aromatase inhibitors (AIs). METHODS: A literature search was performed, without language restrictions, of 10 databases from their inception through February 2014. The literature reviewed included randomized clinical trials (RCTs) and clinical trials that compared real versus sham acupuncture for the treatment of @entity2 ( @entity2 ). The methodologic quality of these trials was assessed by using the modified Jadad Quality Scale. Meta-analytic software (RevMan 5.0) was used to analyze the data. RESULTS: Five To compare the effects of real versus sham acupuncture, five RCTs were assessed by meta-analysis and quality analysis. Three of the RCTs reported favorable effects with regard to use of acupuncture in reducing @entity3 and joint-related symptoms, while the other two RCTs did not. The meta-analysis showed trends toward reduced @entity3 and @entity4 in @entity1 given acupuncture compared with those who received sham treatment (n=82; @entity3 , mean difference: -2.07 [95% confidence interval (CI), -4.72 to 0.57]; p=0.12; @entity4 , mean difference: -86.10 [95% CI, -249.11 to 76.92]; p=0.30), although these differences were not statistically significant. CONCLUSIONS: Acupuncture has been reported as a safe and promising treatment for @entity2 , but the present analysis indicated that the effects were not statistically significant. Other outcome measurements, such as imaging studies, would be worth including in future studies to further confirm the efficacy of acupuncture in @entity2 .

title: Acupuncture for Treating Aromatase Inhibitor-Related @entity5 in XXXX : A Systematic Review and Meta-Analysis.

answer: @entity0


abstract: PURPOSE: Acupuncture has been used as a complementary medical treatment for @entity5 and other types of @entity3 . The objective of this review is to assess the effectiveness of acupuncture in the treatment of @entity5 in @entity1 with @entity0 who were treated with aromatase inhibitors (AIs). METHODS: A literature search was performed, without language restrictions, of 10 databases from their inception through February 2014. The literature reviewed included randomized clinical trials (RCTs) and clinical trials that compared real versus sham acupuncture for the treatment of @entity2 ( @entity2 ). The methodologic quality of these trials was assessed by using the modified Jadad Quality Scale. Meta-analytic software (RevMan 5.0) was used to analyze the data. RESULTS: Five To compare the effects of real versus sham acupuncture, five RCTs were assessed by meta-analysis and quality analysis. Three of the RCTs reported favorable effects with regard to use of acupuncture in reducing @entity3 and joint-related symptoms, while the other two RCTs did not. The meta-analysis showed trends toward reduced @entity3 and @entity4 in @entity1 given acupuncture compared with those who received sham treatment (n=82; @entity3 , mean difference: -2.07 [95% confidence interval (CI), -4.72 to 0.57]; p=0.12; @entity4 , mean difference: -86.10 [95% CI, -249.11 to 76.92]; p=0.30), although these differences were not statistically significant. CONCLUSIONS: Acupuncture has been reported as a safe and promising treatment for @entity2 , but the present analysis indicated that the effects were not statistically significant. Other outcome measurements, such as imaging studies, would be worth including in future studies to further confirm the efficacy of acupuncture in @entity2 .

title: Acupuncture for Treating Aromatase Inhibitor-Related XXXX in @entity0 : A Systematic Review and Meta-Analysis.

answer: @entity5


abstract: OBJECTIVE: To evaluate whether the use of intraoperative @entity4 ( @entity5 ) during @entity1 surgery may reduce the incidence of @entity3 ( @entity3 ). DESIGN: A retrospective study. SETTING: An academic hospital. @entity0 : Data were collected from 1,207 adult @entity0 who underwent resection for non-small-cell @entity1 between January 2004 and December 2012. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: All @entity0 had a general balanced anesthetic technique, and @entity4 use was at the discretion of the anesthesiologist. Data analysis was done utilizing the Wilcoxon rank sum tests and Chi-square tests to compare continuous variables and categoric variables between the 2 groups, respectively. Multivariate logistic analysis with backward selection was fitted to find out factors for @entity3 incidence. Overall, 8.1% of the @entity0 developed @entity3 during their hospital stay. There were no statistically significant differences in demographic, perioperative variables, and the incidence of @entity3 between @entity0 who did and did not receive @entity5 . A logistic regression model was fitted to determine factors independently associated with @entity3 . Factors that were independently associated with @entity3 included body mass index, American Society of Anesthesiologists 3-4, @entity2 , smoking status, and thoracotomy procedure. DISCUSSION: The authors hypothesized that @entity5 use would be associated with a decreased incidence of @entity3 in thoracic surgery; however, they were unable to prove this hypothesis. Their results did demonstrate that there are 5 factors independently associated with @entity3 .

title: The Use of Intraoperative XXXX is Not Associated With a Reduction in Acute Kidney Injury After Lung Cancer Surgery.

answer: @entity4


abstract: OBJECTIVE AND IMPORTANCE: Traumatic @entity1 present diagnostic and therapeutic challenges. Owing to their fragile nature, endovascular intervention has become the first-line treatment; however, direct surgery has an advantage in certain cases. CLINICAL PRESENTATION: A 34-year-old @entity0 in @entity5 was admitted after a motor vehicle accident. Brain computed tomographic scans revealed deep bifrontal, left intraventricular, and @entity3 . Three-dimensional computed tomographic angiography and digital subtraction angiography revealed an @entity2 arising from the left pericallosal artery. INTERVENTION: A massive @entity7 prompted us to perform emergency surgical intervention. We immediately removed the @entity6 and extirpated the @entity2 . After @entity6 evacuation via the interhemispheric approach, a pulsating red sphere projecting from the pericallosal artery, with no obvious solid wall or neck, was encountered. While retracting the frontal lobe, it suddenly ruptured. Under temporary trapping of the parent artery, the point of @entity4 was identified. No @entity2 wall or fibrous tissue was present, whereas a 1.5-mm laceration was observed at the pericallosal artery close to its branching point. The laceration was sutured with 10-0 nylon. Postoperative digital subtraction angiography confirmed patency of the pericallosal artery. CONCLUSIONS: Although recent technologic advances of intravascular surgery have enabled successful treatment of @entity8 , open surgical intervention still has some advantages of providing definitive hemostasis, allowing for parent artery reconstruction, and facilitating mass reduction. The case in the current study was quite unusual in that angiographic @entity2 had disrupted easily, leaving @entity9 . This finding implies the probability of unavoidable parent artery occlusion when endovascular treatment is applied.

title: Surgical Repair of Lacerated Anterior Cerebral Artery Presented With Massive XXXX .

answer: @entity7


abstract: OBJECTIVE: To investigate the clinical features and outcome of outpatient-based physiotherapy (manual stretch) of @entity3 ( @entity3 ) with @entity1 limitation (>= 10  ) according to whether the finding on ultrasonography (US) is normal or abnormal. DESIGN: Case-control study. SETTING: Institutional practice. @entity0 : A total of 149 @entity0 with @entity3 who met eligibility criteria were included: age at presentation  <=6 months, limitation of passive @entity2 (  ROT) or lateral flexion (  LAT) >= 10  , and completion of our outpatient-based physiotherapy program. INTERVENTIONS: @entity0 were allocated to the US-normal or US-abnormal group. @entity0 underwent physiotherapy and were followed-up monthly until   ROT and   LAT were  <=5   or did not respond to treatment. MAIN OUTCOME MEASUREMENTS: Baseline characteristics, initial   ROT and   LAT, age at presentation, treatment durations, and success rates of physiotherapy were compared between 2 groups. Treatment duration was adjusted for initial   ROT,   LAT, and age at presentation using analysis of covariance. RESULTS: Mean initial   ROT and   LAT in US-abnormal (28.5  ; 17.0  ) were greater than in US-normal (7.9  , P < .001; 12.3  , P = .001, respectively). Mean age at presentation was older in US-normal (3.8 months) than in US-abnormal (1.8 months, P < .001). Treatment duration was shorter in the US-normal (5.1 weeks) than US-abnormal (14.9 weeks, P < .001). Adjusted treatment duration was also shorter in US-normal (9.7 weeks) than US-abnormal (13.8 weeks, P < .05). The success rates of physiotherapy were 95% in US-abnormal and 100% in US-normal. Two of 6 treatment failures in the US-abnormal group underwent surgery. CONCLUSIONS: In @entity3 with @entity1 limitation (>= 10  ), @entity0 in the US-normal group demonstrated lesser @entity1 limitation and older age at presentation than US-abnormal. It seems that US-normal showed shorter treatment duration irrespective of severity of neck motion limitation and age at presentation. Additionally, manual stretching applied before 6 months of age appears to show generally good outcome regardless of US findings.

title: A Clinical Comparative Study of Ultrasound-Normal Versus Ultrasound-Abnormal XXXX .

answer: @entity3


abstract: AIM: To report on a possible relationship between the use of dental floss or superfloss and the development of @entity3 . MATERIALS AND METHODS: Ten @entity0 with progressive @entity3 with an intensive oral hygiene protocol, which consisted of extensive professional supra- and submucosal cleaning, and not responding to this therapy were scheduled for examination. Plaque and @entity1 indices and probing depth measurements were assessed, and radiographic examination was performed every two years. RESULTS: In all ten cases, remnants of dental floss were found around the neck and coronal part of a dental implant. After careful removal of these floss remnants and implant cleansing, a significant improvement in the peri-implant conditions in nine of ten cases was noted. In one case, peri-implant probing depth decreased substantially. However, @entity1 on probing was still present. In vitro testing yielded that the application of various types of dental floss on the exposed rough implant surfaces may easily lead to tearing of floss fibers. This may result in the deposition of floss remnants on rough implant surfaces, which, in turn, may lead to the development of plaque-related peri-implant inflammation and, subsequently, @entity2 . CONCLUSION: In case of exposed rough surfaces of the dental implant, the peri-implant conditions may be jeopardized by the application of dental floss, and hence, the utilization of interproximal brushes or toothpicks may be preferred for daily home care practices.

title: Dental floss as a possible risk for the development of XXXX : an observational study of 10 cases.

answer: @entity3


abstract: Recent studies support the use of @entity3 -based therapies in light chain @entity4 ( @entity4 ). We performed a retrospective analysis of the safety, efficacy and long-term survival (median follow-up 3 years) after @entity3 -based treatment in 28 consecutive @entity0 with de novo @entity4 deemed ineligible at initial presentation. The first 14 @entity0 received @entity3 and @entity1 (VD), and the second 14 @entity0 received @entity2 , @entity3 and @entity1 (CVD; CyBorD). Both regimens were well tolerated with no treatment-related mortality. The overall hematological response (HR) rate was 93% in both the groups. Median time to response was shorter in the CVD group (39 days vs 96 days in the VD group; P=0.002). Hematological and organ responses induced with @entity3 -based therapy enabled 8 (33%) of initially transplant ineligible @entity0 to undergo autologous hematopoietic stem cell transplantation (AHCT), including 4 @entity0 with cardiac stage III or IV. Seven of the eight @entity0 (88%) who underwent subsequent AHCT achieved sustained HR at a median of 33 months posttransplant. These data suggest that @entity3 -based induction followed by AHCT is a viable therapeutic strategy for transplant-ineligible @entity4 . Larger, multicenter prospective trials are necessary to confirm our findings.

title: XXXX -based induction for transplant ineligible @entity4 and feasibility of later transplantation.

answer: @entity3


abstract: Recent studies support the use of @entity3 -based therapies in light chain @entity4 ( @entity4 ). We performed a retrospective analysis of the safety, efficacy and long-term survival (median follow-up 3 years) after @entity3 -based treatment in 28 consecutive @entity0 with de novo @entity4 deemed ineligible at initial presentation. The first 14 @entity0 received @entity3 and @entity1 (VD), and the second 14 @entity0 received @entity2 , @entity3 and @entity1 (CVD; CyBorD). Both regimens were well tolerated with no treatment-related mortality. The overall hematological response (HR) rate was 93% in both the groups. Median time to response was shorter in the CVD group (39 days vs 96 days in the VD group; P=0.002). Hematological and organ responses induced with @entity3 -based therapy enabled 8 (33%) of initially transplant ineligible @entity0 to undergo autologous hematopoietic stem cell transplantation (AHCT), including 4 @entity0 with cardiac stage III or IV. Seven of the eight @entity0 (88%) who underwent subsequent AHCT achieved sustained HR at a median of 33 months posttransplant. These data suggest that @entity3 -based induction followed by AHCT is a viable therapeutic strategy for transplant-ineligible @entity4 . Larger, multicenter prospective trials are necessary to confirm our findings.

title: @entity3 -based induction for transplant ineligible XXXX and feasibility of later transplantation.

answer: @entity4


abstract: OBJECTIVE: To assess the diagnostic accuracy of recommendations for self-monitoring blood pressure (BP) for diagnosing @entity1 in primary care. METHODS: Two hundred and forty-seven consecutive @entity0 with raised (>= 130mmHg systolic) BP measured by their general practitioner from four primary care practices in the United Kingdom underwent 28 days of self-monitoring followed by 24-h ambulatory BP monitoring (ABPM). Diagnostic accuracy of the first 7 days of self-monitored BP (minimum 4 days, discarding readings on day 1) in detecting @entity1 with ambulatory blood pressure was taken as reference. RESULTS: Two hundred and three @entity0 were included, 109 (53.7%) of whom were diagnosed with @entity1 using daytime ambulatory BP. The average of days 2-7 self-monitored BP correctly classified 150 of 203 @entity0 [sensitivity 93.6%, 95% confidence interval (CI) 87.2-97.4%; specificity 51.1%, 95% CI 40.5-61.5%). However, the average of days 2-5 self-monitoring correctly classified 152 of 203 @entity0 due to better specificity (53.2%, 95% CI 42.6-63.6%). In sensitivity analysis, diagnostic accuracy was not improved by inclusion of readings beyond day 5, and inclusion of readings taken on day 1 had no impact on diagnostic accuracy. Self-monitoring in the clinic was more accurate than readings taken by the general practitioner, but not self-monitoring outside of the clinic. CONCLUSION: @entity1 can be ruled out in the majority of @entity0 with elevated clinic BP using the average of the first 5 consecutive days of self-monitored BP, supporting lower limits for self-monitoring readings in current guidelines. Performing readings beyond day 5 and including readings taken on the first day had no clinical impact on diagnostic accuracy.

title: Accuracy of self-monitored blood pressure for diagnosing XXXX in primary care.

answer: @entity1


abstract: BACKGROUND/AIMS: This multicenter and single arm phase II clinical trial was performed to examine the safety and efficacy of modified FOLFOX6 (mFOLFOX6) as adjuvant treatment after resection of liver metastases from @entity2 . METHODOLOGY: @entity0 who had undergone R0-1 resection of liver metastases were assigned to 12 cycles of mFOLFOX6. The primary end point was disease-free survival (DFS). RESULTS: We enrolled 49 cases and analyzed adverse events in 48 cases, since in one @entity0 @entity1 recurred before starting treatment. As to the relative dose intensity, @entity9 was 78.8%, and @entity7 was 75.9%. Adverse events of Grade 3 and above includ- ed 18 cases of @entity8 (37.5%), 4 cases of @entity3 (8.3%), 4 cases of @entity6 (8.3%) and 4 cases of @entity4 (8.3%), and there were no cases of @entity10 caused by adverse events. The most difference of adverse event compared with MOSAIC trial (Multicenter International Study of @entity7 / @entity9 -LV in the Adjuvant Treatment of @entity5 ) was @entity6 . The 2-year DFS was 59.2% (95% CI: 36.7-78.4) in the 49 enrolled cases. CONCLUSION: mFOLFOX6 after hepatectomy was tolerable. And mFOLFOX6 also seemed to improve DFS. mFOLFOX is one of the options for such @entity0 and appears promising as an adjuvant treatment.

title: Feasibility Assessment of Modified FOLFOX-6 as adjuvant treatment after resection of liver metastases from XXXX : analyses of a multicenter phase II clinical trial (Miyagi-HBPCOG Trial-001).

answer: @entity2


abstract: BACKGROUND: Little is known of the epidemiology of @entity5 in sub-Saharan Africa. We performed a population-based survey in Zambia using methods previously tested in multiple other countries. METHODS: This cross-sectional survey was conducted by visiting households unannounced, using cluster-randomized sampling, in the mostly urban Lusaka Province and mostly rural Southern Province. Within clusters, households were selected randomly, as was one adult member (18-65 years old) of each selected household. A structured questionnaire, translated into the local languages, was administered face-to-face by trained interviewers. Demographic enquiry was followed by diagnostic questions based on @entity2 . A random sub-sample of @entity0 were invited for subsequent physician-interview to validate the diagnostic part of the questionnaire. RESULTS: Of 1,134 eligible household members contacted, 1,085 (450 male, 887 urban) consented to interview (refusal rate 4.3%). Others who had been selected but remained unavailable on three visits were not counted as refusals since their reasons were unknown, but gave rise to gender biases, being mostly male in urban areas and mostly female in rural areas. Statistical correction was applied. Adjusted for gender and habitation (urban/rural), the 1-year prevalence of any @entity1 was 61.6%, of @entity4 22.9%, of @entity3 ( @entity3 ) 22.8%, of @entity1 on >= 15 days/month 11.5% and of probable medication-overuse @entity1 (pMOH) 7.1%. The adjusted point-prevalence of any @entity1 ( @entity1 yesterday) was 19.1%. There was a small proportion (5.3%) of unclassified @entity1 , some of which may have been secondary. The overwhelmingly strong association was between urban dwelling and pMOH (OR: 8.6; P=0.0001), with an urban prevalence of 14.5% (gender-adjusted). Validation of the questionnaire was limited by @entity0 ' reluctance to present for physician review, substantial delays in doing so and major self-selection bias among those who did. These were unavoidable problems in resource-limited Zambia. CONCLUSIONS: @entity5 , common in high-income countries, are at least as prevalent in Zambia, a sub-Saharan African country. The selectively urban problem of pMOH seems likely to reflect ready availability of non-prescription analgesics, without easy access to professional health care for @entity1 or any focused public-health education regarding correct usage of analgesics or the dangers of their overuse.

title: The epidemiology of XXXX in Zambia: a population-based door-to-door survey.

answer: @entity5


abstract: PURPOSE: To investigate changes in cytokine levels in tears of type 2 @entity1 with or without @entity7 . METHODS: Tears were collected from 15 type 2 @entity1 without @entity7 (DNR), 15 @entity0 with @entity7 (DR), and 15 age and gender matched non- @entity1 controls. Tear concentrations of 27 cytokines were measured by multiplex bead immunoassay. Cytokine differences between groups, ratios of type-1 T helper ( @entity9 )/type-2 T helper (Th2) cytokines and anti-angiogenic/pro-angiogenic cytokines were analyzed statistically. RESULTS: The most abundant cytokine detected in tears was @entity3 ( @entity3 ). In comparison with controls, @entity3 and @entity11 ( @entity11 ) levels were significantly elevated in DR (p=0.016 and 0.036, respectively) and DNR groups (p=0.021 and 0.026, respectively). @entity8 ( @entity8 ) levels were significantly increased in DNR (p=0.016). @entity9 /Th2 cytokines @entity4 ( @entity4 )/ @entity2 and @entity10 / @entity2 ratios were significantly increased in DR compared to controls (p=0.037 and 0.031, respectively). Anti-angiogenic/angiogenic cytokines @entity4 / @entity11 and @entity12 / @entity11 ratios in DR and DNR were significantly decreased compared to controls (p<0.05). @entity12 / @entity6 and IL-12p70/ @entity6 ratios were also significantly decreased in DR compared to controls (p=0.02 and 0.045, respectively). No significant correlation was demonstrated between tear cytokine concentrations and glycosylated hemoglobin (HbA1c) or fasting plasma @entity5 (FPG). CONCLUSIONS: @entity1 tears exhibited elevated levels of @entity3 and @entity11 . The @entity9 /Th2 cytokine balance may shift to a predominantly @entity9 state in DR @entity0 . Pro-angiogenic cytokines are more highly represented than anti-angiogenic cytokines in the tears of @entity1 @entity0 .

title: Changes to tear cytokines of type 2 XXXX @entity0 with or without @entity7 .

answer: @entity1


abstract: PURPOSE: To investigate changes in cytokine levels in tears of type 2 @entity1 with or without @entity7 . METHODS: Tears were collected from 15 type 2 @entity1 without @entity7 (DNR), 15 @entity0 with @entity7 (DR), and 15 age and gender matched non- @entity1 controls. Tear concentrations of 27 cytokines were measured by multiplex bead immunoassay. Cytokine differences between groups, ratios of type-1 T helper ( @entity9 )/type-2 T helper (Th2) cytokines and anti-angiogenic/pro-angiogenic cytokines were analyzed statistically. RESULTS: The most abundant cytokine detected in tears was @entity3 ( @entity3 ). In comparison with controls, @entity3 and @entity11 ( @entity11 ) levels were significantly elevated in DR (p=0.016 and 0.036, respectively) and DNR groups (p=0.021 and 0.026, respectively). @entity8 ( @entity8 ) levels were significantly increased in DNR (p=0.016). @entity9 /Th2 cytokines @entity4 ( @entity4 )/ @entity2 and @entity10 / @entity2 ratios were significantly increased in DR compared to controls (p=0.037 and 0.031, respectively). Anti-angiogenic/angiogenic cytokines @entity4 / @entity11 and @entity12 / @entity11 ratios in DR and DNR were significantly decreased compared to controls (p<0.05). @entity12 / @entity6 and IL-12p70/ @entity6 ratios were also significantly decreased in DR compared to controls (p=0.02 and 0.045, respectively). No significant correlation was demonstrated between tear cytokine concentrations and glycosylated hemoglobin (HbA1c) or fasting plasma @entity5 (FPG). CONCLUSIONS: @entity1 tears exhibited elevated levels of @entity3 and @entity11 . The @entity9 /Th2 cytokine balance may shift to a predominantly @entity9 state in DR @entity0 . Pro-angiogenic cytokines are more highly represented than anti-angiogenic cytokines in the tears of @entity1 @entity0 .

title: Changes to tear cytokines of type 2 @entity1 @entity0 with or without XXXX .

answer: @entity7


abstract: PURPOSE: To investigate changes in cytokine levels in tears of type 2 @entity1 with or without @entity7 . METHODS: Tears were collected from 15 type 2 @entity1 without @entity7 (DNR), 15 @entity0 with @entity7 (DR), and 15 age and gender matched non- @entity1 controls. Tear concentrations of 27 cytokines were measured by multiplex bead immunoassay. Cytokine differences between groups, ratios of type-1 T helper ( @entity9 )/type-2 T helper (Th2) cytokines and anti-angiogenic/pro-angiogenic cytokines were analyzed statistically. RESULTS: The most abundant cytokine detected in tears was @entity3 ( @entity3 ). In comparison with controls, @entity3 and @entity11 ( @entity11 ) levels were significantly elevated in DR (p=0.016 and 0.036, respectively) and DNR groups (p=0.021 and 0.026, respectively). @entity8 ( @entity8 ) levels were significantly increased in DNR (p=0.016). @entity9 /Th2 cytokines @entity4 ( @entity4 )/ @entity2 and @entity10 / @entity2 ratios were significantly increased in DR compared to controls (p=0.037 and 0.031, respectively). Anti-angiogenic/angiogenic cytokines @entity4 / @entity11 and @entity12 / @entity11 ratios in DR and DNR were significantly decreased compared to controls (p<0.05). @entity12 / @entity6 and IL-12p70/ @entity6 ratios were also significantly decreased in DR compared to controls (p=0.02 and 0.045, respectively). No significant correlation was demonstrated between tear cytokine concentrations and glycosylated hemoglobin (HbA1c) or fasting plasma @entity5 (FPG). CONCLUSIONS: @entity1 tears exhibited elevated levels of @entity3 and @entity11 . The @entity9 /Th2 cytokine balance may shift to a predominantly @entity9 state in DR @entity0 . Pro-angiogenic cytokines are more highly represented than anti-angiogenic cytokines in the tears of @entity1 @entity0 .

title: Changes to tear cytokines of type 2 @entity1 XXXX with or without @entity7 .

answer: @entity0


abstract: STUDY OBJECTIVE: The adaptive value of the endogenous circadian clock arises from its ability to synchronize (i.e., entrain) to external light-dark (LD) cycles at an appropriate phase. Studies have suggested that advanced circadian phase alignment might result from shortening of the period length of the clock. Here we explore mechanisms that contribute to an early activity phase in @entity3 ( @entity3 ) @entity1 . METHODS: We investigated circadian rhythms of wheel-running activity in C57BL/6J (B6), @entity3 and 2 strains of B6. @entity3 congenic @entity1 , which carry @entity3 segments introgressed in a B6 genome. RESULTS: When entrained, all @entity3 @entity1 initiate daily activity several hours earlier than normal @entity1 . This difference could not be explained by alterations in the endogenous period, as activity onset did not correlate with period length. However, the photic phase-shifting responses in these @entity1 were phase-lagged by 3 hours relative to their activity. Attenuated light masking responses were also found in @entity3 @entity1 , which allow for activity normally inhibited by light. A previously identified quantitative trait locus (QTL), @entity4 , which contributes to the early activity trait, was confirmed and refined here using two B6. @entity3 congenic strains. Surprisingly, these B6. @entity3 @entity1 exhibited longer rather than shorter endogenous periods, further demonstrating that the advanced phase in these @entity1 is not due to alterations in period. CONCLUSIONS: @entity3 @entity1 have an advanced activity phase similar to @entity0 @entity2 . This advanced phase is not due to its shorter period length or smaller light-induced phase shifts, but appears to be related to both light masking and altered coupling of the circadian pacemaker with various outputs. Lastly, a QTL influencing this trait was confirmed and narrowed using congenic @entity1 as a first step toward gene identification.

title: Behavioral and genetic dissection of a @entity1 model for XXXX .

answer: @entity2


abstract: STUDY OBJECTIVE: The adaptive value of the endogenous circadian clock arises from its ability to synchronize (i.e., entrain) to external light-dark (LD) cycles at an appropriate phase. Studies have suggested that advanced circadian phase alignment might result from shortening of the period length of the clock. Here we explore mechanisms that contribute to an early activity phase in @entity3 ( @entity3 ) @entity1 . METHODS: We investigated circadian rhythms of wheel-running activity in C57BL/6J (B6), @entity3 and 2 strains of B6. @entity3 congenic @entity1 , which carry @entity3 segments introgressed in a B6 genome. RESULTS: When entrained, all @entity3 @entity1 initiate daily activity several hours earlier than normal @entity1 . This difference could not be explained by alterations in the endogenous period, as activity onset did not correlate with period length. However, the photic phase-shifting responses in these @entity1 were phase-lagged by 3 hours relative to their activity. Attenuated light masking responses were also found in @entity3 @entity1 , which allow for activity normally inhibited by light. A previously identified quantitative trait locus (QTL), @entity4 , which contributes to the early activity trait, was confirmed and refined here using two B6. @entity3 congenic strains. Surprisingly, these B6. @entity3 @entity1 exhibited longer rather than shorter endogenous periods, further demonstrating that the advanced phase in these @entity1 is not due to alterations in period. CONCLUSIONS: @entity3 @entity1 have an advanced activity phase similar to @entity0 @entity2 . This advanced phase is not due to its shorter period length or smaller light-induced phase shifts, but appears to be related to both light masking and altered coupling of the circadian pacemaker with various outputs. Lastly, a QTL influencing this trait was confirmed and narrowed using congenic @entity1 as a first step toward gene identification.

title: Behavioral and genetic dissection of a XXXX model for @entity2 .

answer: @entity1


abstract: OBJECTIVE: The physiological persistence of fetal cells in the circulation and tissue of a previously pregnant @entity0 is called fetal cell microchimerism (FCM). It has been hypothesized to play a role in @entity1 ; however, only limited data are available regarding its role in @entity2 ( @entity2 ). DESIGN: Circulating FCM was analyzed in a large series of previously pregnant @entity0 with @entity4 ( @entity4 ), @entity3 ( @entity3 ), or no disease (healthy controls (HCs)). To exclude the possible bias related to placental factors, the polymorphic pattern of human leukocyte antigen-G ( @entity5 ) gene, which is known to be involved in the tolerance of fetal cells by the maternal immune system, was investigated. METHODS: FCM was evaluated by PCR in the peripheral blood, and the Y chromosome was identified by fluorescence in situ hybridization in some @entity4 tissues. @entity5 polymorphism typing was assessed by real-time PCR. RESULTS: FCM was significantly more frequent in HC (63.6%) than in @entity4 (33.3%) or @entity3 (27.8%) @entity0 (P=0.0004 and P=0.001 respectively). A quantitative analysis confirmed that circulating male DNA was more abundant in HC than it was in @entity4 or @entity3 . Microchimeric cells were documented in vessels and in thyroid follicles. In neither @entity4 / @entity3 @entity0 nor HC @entity0 was the @entity5 typing different between FCM-positive and FCM-negative cases. CONCLUSION: The higher prevalence of FCM in HC as compared to @entity4 and @entity3 @entity0 suggests that it plays a possible protective role in @entity2 . Placental factors have been excluded as determinants of the differences found. The vascular and tissue localization of microchimeric cells further highlights the ability of those cells to migrate to damaged tissues.

title: Fetal cell microchimerism: a protective role in XXXX .

answer: @entity2


abstract: BACKGROUND: The demand for scientific biodiversity data is increasing, but taxonomic expertise is often limited or not available. DNA sequencing is a potential remedy to overcome this taxonomic impediment. Mitochondrial DNA is most commonly used, e.g., for species identification ("DNA barcoding"). Here, we present the first study in arthropods based on a near-complete species sampling of a family-level taxon from the entire Australian region. We aimed to assess how reliably mtDNA data can capture species diversity when many sister species pairs are included. Then, we contrasted phylogenetic subsampling with the hitherto more commonly applied geographical subsampling, where sister species are not necessarily captured. METHODOLOGY/PRINCIPAL FINDINGS: We sequenced 800 bp @entity1 for 1,439 individuals including 260 Australian species (78% species coverage). We used clustering with thresholds of 1 to 10% and general mixed Yule Coalescent (GMYC) analysis for the estimation of species @entity0 . The performance metrics used were taxonomic accuracy and agreement between the morphological and molecular species @entity0 estimation. Clustering (at the 3% level) and GMYC reliably estimated species diversity for single or multiple geographic regions, with an error for larger clades of lower than 10%, thus outperforming parataxonomy. However, the rates of error were higher for some individual genera, with values of up to 45% when very recent species formed nonmonophyletic clusters. Taxonomic accuracy was always lower, with error rates above 20% and a larger variation at the genus level (0 to 70%). S  rensen similarity indices calculated for morphospecies, 3% clusters and GMYC entities for different pairs of localities was consistent among methods and showed expected decrease over distance. CONCLUSION/SIGNIFICANCE: @entity1 sequence data are a powerful tool for large-scale species @entity0 estimation, with a great potential for use in ecology and b-diversity studies and for setting conservation priorities. However, error rates can be high in individual lineages.

title: Mitochondrial XXXX sequence data reliably uncover patterns of insect diversity but suffer from high lineage-idiosyncratic error rates.

answer: @entity1


abstract: OBJECTIVE: To analyze the causes of the @entity6 and @entity2 of free flaps used for reconstruction of defects following @entity4 resection and the managements of these issues. METHODS: A total of 850 cases with @entity4 who underwent free flap reconstruction from October 2010 to April 2014 were studied retrospectively. The risks for @entity6 and @entity2 were analyzed with one-factor analysis and multivariate analysis. RESULTS: The total success rate of 95.1% (808/850) for the free flap reconstruction was obtained. Twelve flaps due to poor blood supply indicated during operation were replaced by other free flaps. Among 73 flaps with @entity6 , 31 flaps were salvaged by surgical exploration and subcutaneous injection of low molecular heparin @entity7 . Obesity, smoking, preoperative radiotherapy and surgeon's experience, rather than age, @entity3 and @entity1 , were the risk factors of @entity2 . Two-vein @entity5 had a higher success rate than one-vein @entity5 . CONCLUSIONS: The @entity2 rate of free flaps can be reduced by the choice of suitable flaps, subtly preparation of flaps, carefully vascular @entity5 , and prompt perioperative managements. The two-vein @entity5 is recommended. @entity1 , @entity3 and elderly @entity0 are not the contraindications for free flap reconstruction.

title: [Analysis of the causes of flap XXXX after head and neck reconstruction].

answer: @entity2


abstract: INTRODUCTION: @entity1 chemotherapy in the United States has been delivered mostly in an office-based setting since the late 1980s. However, in the past 5 years, more @entity0 have been treated in hospitals as a result of reimbursement changes. Intraperitoneal (IP) chemotherapy for @entity2 has been similarly affected. This report examines changes in care of @entity0 treated with IP chemotherapy in an office- versus hospital-based setting. METHODS: Over 10 years, 140 @entity0 with @entity2 were identified as candidates for IP chemotherapy. Of these @entity0 , 92 were treated in an oncology-dedicated infusion center in the office of a physicians' group; 48 were treated in a local hospital. Location was determined based on insurance coverage and reimbursement. Data collected included demographics, number of treatment cycles completed, length of each treatment, and adverse events. RESULTS: The age and ethnicity of @entity0 treated in the office versus hospital were similar. All six doses of intravenous IP chemotherapy were completed by 73 (79%) of 92 @entity0 treated in the office versus 23 (48%) of 48 @entity0 treated in the hospital (P < .001). The time of each infusion was longer in the hospital-versus office-based setting (P < .001). There were more adverse events associated with treatment in the hospital. CONCLUSION: IP chemotherapy is associated with worse outcomes in the hospital- compared with office-based setting. The reason seems to involve a relative lack of resources directed specifically to chemotherapy administration. If current reimbursement trends continue, this could result in decreased survival for @entity0 with @entity2 .

title: Impact of shifting from office- to hospital-based treatment facilities on the administration of intraperitoneal chemotherapy for XXXX .

answer: @entity2


abstract: OBJECTIVE: To explore the computed tomographic (CT) and pathological findings of small @entity6 and improve its understanding. METHODS: A total of 20 @entity0 with bile duct non-dilatation peripheral small @entity6 were retrospectively analyzed. All of them were examined by plain and enhanced CT and pathological studies. RESULTS: CT plain scan:there were 15 cases of low-density lesions with fibers and @entity2 tissue and surviving @entity1 tissue in peripheral or central portions. There were 4 cases of lesions with mixed high and low densities. Abundant @entity2 tissues were found with a rare vascular distribution.Or abundant fibers and connective tissues around @entity1 were manifested as @entity3 .One lesion showed equal density with abundant @entity2 tissue and fibrous connective tissue with @entity5 tissue; dynamic contrast-enhanced CT: (1) there were 6 cases of lesion with peripheral thin ring-enhanced and @entity1 margin of viable @entity1 tissue. And internal @entity1 was fibrous tissue; (2) there were 7 cases of lesions with peripheral thick ring-enhanced and enhanced portion was surviving @entity1 tissue, no enhanced central portion was mainly @entity2 tissue mixed with little fibrous tissue; (3) there were 2 cases of @entity1 without enhancement. There were significant @entity4 and @entity2 with few surviving @entity1 cells in @entity1 and normal liver tissue; (4) there were 5 cases of lesions with heterogeneous enhancement and the heterogeneous enhancement portion was surviving @entity1 tissue and little fibrous connective tissue. And some @entity2 tissue remained; (5) only one case had overall enhancement of same-sized @entity1 cells without @entity2 . CONCLUSION: CT scanning of peripheral small @entity3 lacks distinguishing characteristics. However the findings of contrast-enhanced CT have certain characteristics. Due to different pathological types, each attribute has corresponding characteristic with different pathological features.

title: [Comparison study of small peripheral XXXX with computed tomographic and pathological findings].

answer: @entity6


abstract: INTRODUCTION: When occurring in childhood, @entity6 joint is responsible for complex @entity1 , including mandibular growth deficiency. We present a case of temporomandibular joint @entity4 associated with severe mandibular asymmetry treated by mandibular bone distraction performed under computer assistance. OBSERVATION: A 27-year-old @entity0 presented with a severe @entity5 consisting in @entity2 of the left hemi-mandible and maxilla. Mouth opening was non-existent. The CT-scan showed a left @entity6 . A left mandibular distraction was decided. The distraction characteristics (choice and positioning of the distractor, @entity3 and amount of distraction) were determined preoperatively on the 3D CT-scan. The planning has been transferred to a navigation console (Kolibri(  ), Brainlab(  )). A combined intraoral and cutaneous was performed. Navigation allowed for an appropriate placement of the osteotomy line and fixation of the distractor. Distraction was started at the 5th postoperative day at the rate of 1mm per day and lasted 25 days without complication. DISCUSSION: 3D planning allows for better indication setting, better preparation of the procedure, reducing complications and operative time. It may help as an educational tool for young surgeons and for a better understanding from the @entity0 . Navigation is an accurate method for the transfer of the planning in the operation room.

title: [3D mandibular distraction planification in a case of severe XXXX ].

answer: @entity6


abstract: Background. The aim was to examine the association of @entity2 with fish eating habits, in elderly individuals. Methods. From June to October of 2009, we studied 330 @entity0 and 343 @entity0 , aged 65 to 100 years, permanent inhabitants of Ikaria Island. Among several characteristics, @entity2 was assessed with the Geriatric @entity2 scale (GDS range 0-15), while dietary habits through a valid semiquantitative food frequency questionnaire. Results. @entity0 had significantly higher values of the GDS compared to @entity0 (4.8    3.5 versus 3.3    3.1, P = .001). @entity0 in the upper tertile of @entity2 scale ate less frequent fish and consumed higher quantities of @entity1 , compared to those in the lowest tertile (all P < .05). Regarding fish consumption, 50% of the individuals reported consuming 1-2 times weekly, 32% 3 to 5 times weekly, 11% 2-3 times monthly, while the rest reported rare (4.5%) and everyday (1.2%) consumption. Logistic regression showed that increased fish consumption (>3 times/week versus never/rare) was inversely associated with the odds of having GDS greater the median value (i.e., 4) (odds      ratio = 0.34, 95% CI: 0.19, 0.61), after controlling for several cofounders. Conclusion. Frequent fish consumption in elderly seems to moderate @entity2 mood.

title: Fish Consumption Moderates Depressive Symptomatology in Elderly XXXX and @entity0 from the IKARIA Study.

answer: @entity0


abstract: Background. The aim was to examine the association of @entity2 with fish eating habits, in elderly individuals. Methods. From June to October of 2009, we studied 330 @entity0 and 343 @entity0 , aged 65 to 100 years, permanent inhabitants of Ikaria Island. Among several characteristics, @entity2 was assessed with the Geriatric @entity2 scale (GDS range 0-15), while dietary habits through a valid semiquantitative food frequency questionnaire. Results. @entity0 had significantly higher values of the GDS compared to @entity0 (4.8    3.5 versus 3.3    3.1, P = .001). @entity0 in the upper tertile of @entity2 scale ate less frequent fish and consumed higher quantities of @entity1 , compared to those in the lowest tertile (all P < .05). Regarding fish consumption, 50% of the individuals reported consuming 1-2 times weekly, 32% 3 to 5 times weekly, 11% 2-3 times monthly, while the rest reported rare (4.5%) and everyday (1.2%) consumption. Logistic regression showed that increased fish consumption (>3 times/week versus never/rare) was inversely associated with the odds of having GDS greater the median value (i.e., 4) (odds      ratio = 0.34, 95% CI: 0.19, 0.61), after controlling for several cofounders. Conclusion. Frequent fish consumption in elderly seems to moderate @entity2 mood.

title: Fish Consumption Moderates Depressive Symptomatology in Elderly @entity0 and XXXX from the IKARIA Study.

answer: @entity0


abstract: AIM: Increased serum levels of the activated aspartic lysosomal endopeptidase @entity5 ( @entity5 ) have been found in @entity0 with @entity3 ( @entity3 ). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of @entity4 . This study aimed to evaluate the role of serum @entity5 activity in the development of @entity4 in @entity0 with @entity3 ( @entity3 ). @entity0 AND METHODS: Eighty-eight consecutive @entity0 (79.5   % @entity0 , mean age 57.4        10.2  years) with @entity3 were included in this study. Serum @entity5 activity was measured directly after primary percutaneous coronary intervention (PCI), before discharge, and at the 6-month follow-up. @entity0 were monitored for major adverse cardiovascular events (MACE), defined as hospitalization due to cardiovascular causes, recurrent nonfatal @entity3 , unplanned PCI, new-onset @entity4 , and @entity1 . RESULTS: Serum @entity5 activity was significantly higher in @entity0 with @entity3 after PCI and during follow-up (FU) than that in age-matched controls (16.2        7.5 and 29.8        8.9 vs. 8.5        4.2 RFU; p   <   0.001 for each time point). At the 6-month follow-up, serum @entity5 activity in these @entity0 was inversely related to new-onset @entity2 compared with @entity0 with preserved and improved LVEF after treatment (23.1        3.2 vs. 28.8        7.0 and 29.7        5.0 RFU respectively, p   <   0.01). @entity0 suffering from MACE during a follow-up period of 6  months had lower serum levels of activated @entity5 than those without any MACE (23.8        4.6 vs 29.6        6.9 RFU; p   <   0.001). CONCLUSIONS: Serum @entity5 activity as a marker of healthy endogenous phagocytosis and remodeling was impaired in @entity0 with new-onset @entity2 , and lower levels of serum @entity5 were associated with MACE at the 6-month post-MI follow-up.

title: Role of @entity5 activation in major adverse cardiovascular events and new-onset XXXX after @entity3 .

answer: @entity4


abstract: AIM: Increased serum levels of the activated aspartic lysosomal endopeptidase @entity5 ( @entity5 ) have been found in @entity0 with @entity3 ( @entity3 ). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of @entity4 . This study aimed to evaluate the role of serum @entity5 activity in the development of @entity4 in @entity0 with @entity3 ( @entity3 ). @entity0 AND METHODS: Eighty-eight consecutive @entity0 (79.5   % @entity0 , mean age 57.4        10.2  years) with @entity3 were included in this study. Serum @entity5 activity was measured directly after primary percutaneous coronary intervention (PCI), before discharge, and at the 6-month follow-up. @entity0 were monitored for major adverse cardiovascular events (MACE), defined as hospitalization due to cardiovascular causes, recurrent nonfatal @entity3 , unplanned PCI, new-onset @entity4 , and @entity1 . RESULTS: Serum @entity5 activity was significantly higher in @entity0 with @entity3 after PCI and during follow-up (FU) than that in age-matched controls (16.2        7.5 and 29.8        8.9 vs. 8.5        4.2 RFU; p   <   0.001 for each time point). At the 6-month follow-up, serum @entity5 activity in these @entity0 was inversely related to new-onset @entity2 compared with @entity0 with preserved and improved LVEF after treatment (23.1        3.2 vs. 28.8        7.0 and 29.7        5.0 RFU respectively, p   <   0.01). @entity0 suffering from MACE during a follow-up period of 6  months had lower serum levels of activated @entity5 than those without any MACE (23.8        4.6 vs 29.6        6.9 RFU; p   <   0.001). CONCLUSIONS: Serum @entity5 activity as a marker of healthy endogenous phagocytosis and remodeling was impaired in @entity0 with new-onset @entity2 , and lower levels of serum @entity5 were associated with MACE at the 6-month post-MI follow-up.

title: Role of XXXX activation in major adverse cardiovascular events and new-onset @entity4 after @entity3 .

answer: @entity5


abstract: AIM: Increased serum levels of the activated aspartic lysosomal endopeptidase @entity5 ( @entity5 ) have been found in @entity0 with @entity3 ( @entity3 ). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of @entity4 . This study aimed to evaluate the role of serum @entity5 activity in the development of @entity4 in @entity0 with @entity3 ( @entity3 ). @entity0 AND METHODS: Eighty-eight consecutive @entity0 (79.5   % @entity0 , mean age 57.4        10.2  years) with @entity3 were included in this study. Serum @entity5 activity was measured directly after primary percutaneous coronary intervention (PCI), before discharge, and at the 6-month follow-up. @entity0 were monitored for major adverse cardiovascular events (MACE), defined as hospitalization due to cardiovascular causes, recurrent nonfatal @entity3 , unplanned PCI, new-onset @entity4 , and @entity1 . RESULTS: Serum @entity5 activity was significantly higher in @entity0 with @entity3 after PCI and during follow-up (FU) than that in age-matched controls (16.2        7.5 and 29.8        8.9 vs. 8.5        4.2 RFU; p   <   0.001 for each time point). At the 6-month follow-up, serum @entity5 activity in these @entity0 was inversely related to new-onset @entity2 compared with @entity0 with preserved and improved LVEF after treatment (23.1        3.2 vs. 28.8        7.0 and 29.7        5.0 RFU respectively, p   <   0.01). @entity0 suffering from MACE during a follow-up period of 6  months had lower serum levels of activated @entity5 than those without any MACE (23.8        4.6 vs 29.6        6.9 RFU; p   <   0.001). CONCLUSIONS: Serum @entity5 activity as a marker of healthy endogenous phagocytosis and remodeling was impaired in @entity0 with new-onset @entity2 , and lower levels of serum @entity5 were associated with MACE at the 6-month post-MI follow-up.

title: Role of @entity5 activation in major adverse cardiovascular events and new-onset @entity4 after XXXX .

answer: @entity3


abstract: AIMS: The typical ultrasound features of @entity5 are considered to be the well-defined contour, the regular, sometimes lobulated shape, homogeneous structure and poor vascularization. The goal of our study was to verify the validity of these features and to identify a typical sonoelastographic pattern for @entity5 . @entity0 AND METHODS: Between April 2007 and February 2010, 70 salivary gland masses were examined prospectively (58 in the parotid gland, 12 in the submandibular gland). The following features were targeted: size, limits, contour, structure, echogenicity, vascularization, elasticity/stiffness. RESULTS: Of the 70 @entity1 , 32 (45.7%) were @entity5 , 12 (17.1%) Warthin @entity1 , 9 (12.8%) other @entity1 , 13 (18.5%) primary @entity1 , 3 metastases from @entity3 , and 1 @entity4 . Among @entity5 , 15 (46.9%) were inhomogeneous, 7 (21.9%) contained @entity2 areas and 14 (43.7%) were well-vascularized. The lobulated contour was identified in 14 @entity5 (43.7%), no other @entity1 presented this type of contour, but it was identified in 2 @entity1 (15.3%). On sonoelastography, most @entity5 were heterogeneous. The elastic component represented more than 50% of the @entity1 tissue in 22 cases (68.7%). This aspect was also identified for 6 @entity1 (46.1%). CONCLUSIONS: Our results demonstrate that features such as heterogeneous structure, rich vascularization and intra-tumoral @entity2 may be identified in a significant number of @entity5 . The most specific element in our group was the presence of a lobulated contour, which was not seen in any other @entity1 , but may rarely appear in certain @entity1 . The elastographic aspect was heterogeneous for most @entity1 , but the elastic composition identified in most @entity5 was also present in a significant proportion of @entity1 . Therefore, a typical sonoelastographic pattern for @entity5 could not be identified.

title: Ultrasonographic and sonoelastographic features of XXXX of the salivary glands.

answer: @entity5


abstract: Working with animals on agricultural operations is hazardous for youths. This study evaluated the associations between activities and @entity0 related to specific animal types. A case-control study within the Regional Rural Injury Study II included 425 youths (less than 20 years of age) with @entity0 related to their operation and 1,886 controls (randomly selected youths). Exposures of interest were collected for the months prior to injury events for cases and randomly selected months for controls, based on an injury incidence algorithm. Multivariate logistic regression characterized associations between specific animal-related activities and injury outcomes among youths who reported working with the same animals. Large proportions of cases and controls, respectively, worked with beef @entity1 (47%, 28%), followed by @entity2 (28%, 14%), and dairy @entity1 (22%, 12%). Feeding was the primary activity associated with animals; over 80% of cases and controls were involved in this activity during relevant exposure months, followed by milking (63%, 44%) among those working with dairy @entity1 and herding (81%, 61%) among beef @entity1 workers. Elevated risk of dairy @entity1 -related injury was associated with milking (odds ratio [OR]: 2.5; 95% confidence interval [CI]: 1.0-6.6) whereas beef @entity1 -related @entity0 were associated with calving (OR: 4.2; 95% CI: 2.1-8.6) and footwork (OR: 2.2; 95% CI: 1.0-4.9). Among youths working with animals, explicit activities can be identified that are associated with animal-specific @entity0 . The identification of relevant hazardous tasks is necessary for the development of effective prevention measures.

title: Animal-related activities as risk factors for XXXX among youth on agricultural operations.

answer: @entity0


abstract: BACKGROUND: @entity0 who have suffered from @entity3 have a high risk of recurrent vascular events. Predictive models based on classical risk factors typically have limited prognostic value. Given that @entity3 has a heritable component, genetic information might improve performance of these risk models. Our aim was to develop and compare two models: one containing traditional vascular risk factors, the other also including genetic information. METHODS AND RESULTS: We studied 1020 @entity0 with @entity3 and genotyped them with the Illumina Immunochip. Median follow-up time was 6.5 years; the annual incidence of new @entity1 events (primary outcome, n=198) was 3.0%. The prognostic model based on classical vascular risk factors had an area under the receiver operating characteristics curve (AUC-ROC) of 0.65 (95% confidence interval 0.61-0.69). When we added a genetic risk score based on prioritized SNPs from a genome-wide association study of @entity2 (using summary statistics from the METASTROKE study which included 12389 cases and 62004 controls), the AUC-ROC remained the same. Similar results were found for the secondary outcome @entity2 . CONCLUSIONS: We found no additional value of genetic information in a prognostic model for the risk of @entity1 events in @entity0 with @entity3 of arterial origin. This is consistent with a complex, polygenic architecture, where many genes of weak effect likely act in concert to influence the heritable risk of an individual to develop (recurrent) vascular events. At present, genetic information cannot help clinicians to distinguish @entity0 at high risk for recurrent vascular events.

title: No Additional Prognostic Value of Genetic Information in the Prediction of Vascular Events after XXXX of Arterial Origin: The PROMISe Study.

answer: @entity3


abstract: Dental @entity0 arises from exposed dentin following bacterial, chemical, or mechanical erosion of enamel and/or recession of gingiva. Thus, dentin tissue and more specifically patent dentinal tubules represent the first structure involved in dentin sensitivity. Interestingly, the architecture of dentin could allow for the transfer of information to the underlying dental pulp via odontoblasts (dentin-forming cells), via their apical extension bathed in the dentinal fluid running in the tubules, or via a dense network of trigeminal sensory axons intimately related to odontoblasts. Therefore, external stimuli causing dentinal fluid movements and odontoblasts and/or nerve complex responses may represent a unique mechanosensory system bringing a new role for odontoblasts as sensor cells. How cells sense signals and how the latter are transmitted to axons represent the main questions to be resolved. However, several lines of evidence have demonstrated that odontoblasts express mechano- and/or thermosensitive transient receptor potential ion channels ( @entity2 , @entity4 , @entity3 , @entity6 , @entity8 , @entity5 , @entity7 ) that are likely to sense heat and/or cold or movements of dentinal fluid within tubules. Added to this, voltage-gated @entity1 channels confer excitable properties of odontoblasts in vitro in response to injection of depolarizing currents. In vivo, @entity1 channels co-localize with nerve terminals at the apical pole of odontoblasts and correlate with the spatial distribution of stretch-activated @entity5 channels. This highlights the terminal web as the pivotal zone of the pulp/dentin complex for sensing external stimuli. Crosstalk between odontoblasts and axons may take place by the release of mediators in the gap space between odontoblasts and axons in view of evidence for nociception-transducing receptors on trigeminal afferent fibers and expression of putative effectors by odontoblasts. Finally, how axons are guided to the target cells and which kind of signaling molecules are involved is extensively discussed in this review.

title: Topical review. Dental XXXX and odontoblasts: facts and hypotheses.

answer: @entity0