abstract: BACKGROUND/OBJECTIVES: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in @entity0 . We hypothesized that a combination of extracts from grape seed and skin (330   mg), green tea (100   mg), @entity9 (60   mg) and a blend of @entity6 , @entity10 and bilberry (60   mg) would reduce blood pressure (BP) in @entity1 subjects. SUBJECTS/METHODS: Eighteen individuals meeting BP requirements (   130   mm   Hg systolic or    85   mm   Hg diastolic) and criteria for @entity2 were enrolled in a double-blinded, placebo-controlled, crossover trial (ClinicalTrials.gov, NCT01106170). The 28-day placebo and supplement arms were separated by a 2-week washout period, and 14   -h daytime ambulatory BP was assessed at baseline and at the end point of each arm. RESULTS: BP was not altered after placebo. After supplement treatment, diastolic pressure was reduced by 4.4   mm   Hg (P=0.024, 95% CI, 0.6-8.1), systolic pressure was unchanged and mean arterial pressure trended (P=0.052) toward reduction. Serum angiotensin-converting enzyme activity was similar between placebo and supplement arms, but urinary @entity4 and @entity8 concentrations were significantly increased (P=0.022) after supplementation. @entity0 aortic endothelial cells treated with metabolites of the @entity11 used in the @entity0 supplement trial had a significant increase (P=0.005) in insulin-stimulated eNOS phosphorylation and greater (P<0.001) accumulation of @entity7 / @entity5 . CONCLUSIONS: Our clinical and in vitro data support the theory that this combination of @entity11 reduced diastolic pressure by potentiating eNOS activation and @entity3 production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP.

title: A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of XXXX subjects.

answer: @entity1


abstract: BACKGROUND: There is limited knowledge of how co-morbidities influence survival after surgery for @entity1 . This population-based cohort study investigated how Charlson co-morbidity index and specific co-morbidities influenced all-cause and disease-specific mortality. METHODS: Data from all @entity0 who underwent @entity1 surgery in Sweden in 1987-2010, with follow-up until 2012, came from histopathology records, operation charts and nationwide registers. Associations between co-morbidities (Charlson co-morbidity index) and mortality were analysed using Cox proportional hazard regression with adjustment for potential confounding, and presented as hazard ratio (HR) with 95 per cent c.i. RESULTS: Among 1822 @entity0 there were 1474 deaths (80  9 per cent), of which 1139 (77  3 per cent) occurred between 91 days and 5 years after surgery. Overall all-cause mortality was increased in @entity0 with a Charlson score of 2 or more (HR 1  24, 95 per cent c.i. 1  08 to 1  42), and those with a history of @entity6 (HR 1  23, 1  01 to 1  49) or @entity7 (HR 1  31, 1  04 to 1  67). @entity0 with @entity8 had increased overall all-cause mortality if they had been diagnosed with @entity1 (HR 1  36, 1  09 to 1  71), whereas those with @entity4 did not. A Charlson score of 1 or exposure to the co-morbidity groups peripheral @entity5 , @entity2 , connective tissue disease, @entity9 , @entity3 did not increase mortality. The disease-specific results were generally similar to the all-cause mortality data. CONCLUSION: Co-morbidity with a Charlson score of 2 or more, previous @entity6 and @entity7 were associated with increased mortality after @entity1 surgery undertaken with curative intent.

title: Impact of co-morbidity on mortality after XXXX surgery.

answer: @entity1


abstract: BACKGROUND: @entity3 positron emission tomography (FDG-PET) is valuable in staging of @entity2 . However, FDG-PET may falsely upstage @entity0 leading to incorrect exclusion from surgical treatment. This study was performed to determine the false-positive rate and possible causes. METHODS: The rate of false-positive lesions on FDG-PET was documented in 86 out of a group of 98 @entity0 . Lesions were defined as false positive when pathological examination was negative or as absence of @entity1 activity within 6 months of follow-up. To evaluate the influence of a learning curve on the false-positive rate, the PET scans were revised recently. RESULTS: False-positive lesions were found in 13 @entity0 (13 of 86; 15%). FDG-PET incorrectly revealed only locoregional node metastases in 5 @entity0 in whom surgery with curative intent was performed. Ten lesions in the other 8 @entity0 were classified as distant organ or as nonregional node metastases (M1a/1b). Finally, 5 @entity0 upstaged to M1a/1b underwent a curative resection. The number of false-positive lesions decreased from 16 to 5 (6%) after revision. CONCLUSIONS: Proper interpretation of FDG-PET in staging @entity2 is impeded by false-positive results. Even after completion of the learning curve, positive FDG-PET findings still have to be confirmed by additional investigations.

title: Pitfalls of positive findings in staging XXXX with @entity3 positron emission tomography.

answer: @entity2


abstract: BACKGROUND: @entity3 positron emission tomography (FDG-PET) is valuable in staging of @entity2 . However, FDG-PET may falsely upstage @entity0 leading to incorrect exclusion from surgical treatment. This study was performed to determine the false-positive rate and possible causes. METHODS: The rate of false-positive lesions on FDG-PET was documented in 86 out of a group of 98 @entity0 . Lesions were defined as false positive when pathological examination was negative or as absence of @entity1 activity within 6 months of follow-up. To evaluate the influence of a learning curve on the false-positive rate, the PET scans were revised recently. RESULTS: False-positive lesions were found in 13 @entity0 (13 of 86; 15%). FDG-PET incorrectly revealed only locoregional node metastases in 5 @entity0 in whom surgery with curative intent was performed. Ten lesions in the other 8 @entity0 were classified as distant organ or as nonregional node metastases (M1a/1b). Finally, 5 @entity0 upstaged to M1a/1b underwent a curative resection. The number of false-positive lesions decreased from 16 to 5 (6%) after revision. CONCLUSIONS: Proper interpretation of FDG-PET in staging @entity2 is impeded by false-positive results. Even after completion of the learning curve, positive FDG-PET findings still have to be confirmed by additional investigations.

title: Pitfalls of positive findings in staging @entity2 with XXXX positron emission tomography.

answer: @entity3


abstract: OBJECTIVE: To compare the efficacy of handrubbing with an @entity1 based solution versus conventional handwashing with antiseptic soap in reducing hand contamination during routine @entity0 care. DESIGN: Randomised controlled trial during daily nursing sessions of 2 to 3 hours. SETTING: Three intensive care units in a French university hospital. @entity0 : 23 healthcare workers. INTERVENTIONS: Handrubbing with @entity1 based solution (n=12) or handwashing with antiseptic soap (n=11) when hand hygiene was indicated before and after @entity0 care. Imprints taken of fingertips and palm of dominant hand before and after hand hygiene procedure. Bacterial counts quantified blindly. MAIN OUTCOME MEASURES: Bacterial reduction of hand contamination. RESULTS: With handrubbing the median percentage reduction in bacterial contamination was significantly higher than with handwashing (83% v 58%, P=0.012), with a median difference in the percentage reduction of 26% (95% confidence interval 8% to 44%). The median duration of hand hygiene was 30 seconds in each group. CONCLUSIONS: During routine @entity0 care handrubbing with an @entity1 based solution is significantly more efficient in reducing hand contamination than handwashing with antiseptic soap.

title: Efficacy of handrubbing with XXXX based solution versus standard handwashing with antiseptic soap: randomised clinical trial.

answer: @entity1


abstract: OBJECTIVES: African Americans with @entity6 receive cardiac catheterization less frequently than whites. The objective was to determine if such disparities extend to acute evaluation and non interventional treatment. METHODS: Data on adults with @entity4 (N = 7,935) presenting to eight emergency departments (EDs) were evaluated from the Internet Tracking Registry of Acute @entity1 . Groups were selected from final ED diagnosis: 1) @entity3 ( @entity3 ), n = 400; 2) unstable @entity5 /non-ST-elevation @entity3 (UA/NSTEMI), n = 1,153; and 3) nonacute coronary syndrome @entity4 (non-ACS @entity7 ), n = 6,382. American College of Cardiology/American Heart Association guidelines for @entity3 and UA/NSTEMI were used to evaluate racial disparities with logistic regression models. Odds ratios (ORs) were adjusted for age, gender, guideline publication, and insurance status. Non-ACS @entity7 @entity0 were assessed by comparing electrocardiographic (ECG)/laboratory evaluation, medical treatment, admission rates, and invasive and noninvasive testing for @entity2 ( @entity2 ). RESULTS: African Americans with UA/NSTEMI received glycoprotein IIb/IIIa receptor inhibitors less often than whites (OR, 0.41; 95% CI = 0.19 to 0.91). African Americans with non-ACS @entity7 underwent ECG/laboratory evaluation, medical treatment, and invasive and noninvasive testing for @entity2 less often than whites (p < 0.05). Other nonwhites with non-ACS @entity7 were admitted and received invasive testing for @entity2 less often than whites (p < 0.01). African Americans and other nonwhites with @entity3 underwent catheterization less frequently than whites (OR, 0.45; 95% CI = 0.29 to 0.71 and OR, 0.40; 95% CI = 0.17 to 0.92, respectively). A similar disparity in catheterization was noted in UA/NSTEMI therapy (OR, 0.53; 95% CI = 0.40 to 0.68 and OR, 0.68; 95% CI = 0.47 to 0.99). CONCLUSIONS: Racial disparities in acute @entity4 management extend beyond cardiac catheterization. Poor compliance with recommended treatments for ACS may be an explanation.

title: The impact of race on the acute management of XXXX .

answer: @entity4


abstract: OBJECTIVE: To evaluate @entity4 after transpupillary thermotherapy used as the sole treatment for @entity3 . DESIGN: Prospective noncomparative interventional case series. @entity0 : Forty-five eyes of 45 @entity0 affected by malignant @entity3 treated with transpupillary thermotherapy alone with more than 1 year of follow-up. INTERVENTION: Transpupillary thermotherapy was performed through a panfunduscopic contact lens using an 810-nm diode laser. MAIN OUTCOME MEASURES: Dynamic/static @entity5 and @entity6 angiography were performed at scheduled intervals (24 hours, at 3-month intervals during the first year, and every 6 months thereafter) after transpupillary thermotherapy. Visual acuity, clinical evaluation, fundus photographs, and ultrasonographic examination were also performed. RESULTS: The mean follow-up was 30.5 months (range, 12-54 months). Changes in the choroidal circulation were always confined within the treatment margins (except in one case) and characterized by occlusion of choriocapillaris (100%), patent medium and/or large choroidal vessels (76%), @entity2 (11%), and progressive @entity7 (42%). Forty-one cases (91%) showed persistent clinical regression, and four cases (9%) recurred; recurrent cases showed @entity2 . CONCLUSIONS: Transpupillary thermotherapy is suggested as a new single therapeutic modality in the treatment of selected @entity3 , but more precise eligibility criteria and longer follow-up are mandatory. Patent choroidal circulation, @entity7 , and @entity2 after transpupillary thermotherapy might be helpful to detect recurrent @entity1 .

title: Choroidal vascular changes after transpupillary thermotherapy for XXXX .

answer: @entity3


abstract: OBJECTIVE: To analyze the data on @entity0 operated on for @entity8 ( @entity7 ) with (Group I) or without (Group II) a correct @entity7 diagnosis and preoperative anti- @entity7 treatment. METHODS: Between 1980 and 1997, 144 resections for @entity7 (Groups I+II) were performed. The 80 @entity0 in Group I underwent therapeutic resections: 32 cases involved recurrent @entity10 or @entity9 , three involved post- @entity7 bronchiectasis, 13 involved progression of @entity10 or @entity9 , and 32 involved persistent @entity9 after 6 months of anti- @entity7 therapy. The 64 @entity0 in Group II were operated on for a suspicion of @entity1 in 49 cases, for cavitary lesions with haemophthysis in six cases, for @entity2 in seven cases, and for recurrent hydrothorax in two cases. RESULTS: Groups I and II included 0 and five pneumonectomies, 32 and 29 lobectomies, 48 and 20 wedge resections, 0 and nine videothoracoscopic biopsies, and 0 and one hilar lymphadenectomy, respectively. In Groups I and II, the mean duration of postoperative hospitalization was 13.2 and 10.4 days, and the frequency of @entity3 was 11.25 and 4.6%, respectively. The incidence of @entity6 was 1.25 and 0%, the mortality was 0 and 3.1%, and the morbidity was 53.7 and 35.9% in Groups I and II, respectively. Two @entity0 with active disease died in Group II. Pathology demonstrated that the frequency of acid-fast bacilli in Groups I and II was 40 and 25%, respectively. CONCLUSIONS: @entity0 without a correct preoperative @entity7 diagnosis underwent more extensive parenchyma resection. @entity5 increased when acid-fast bacilli were present. The lack of preoperative anti- @entity7 treatment did not involve a higher risk of minor complications, but @entity4 occurred only in this group.

title: Surgical intervention for XXXX : analysis of indications and perioperative data relating to diagnostic and therapeutic resections.

answer: @entity8


abstract: OBJECTIVE: We evaluated the results of surgical treatment postinfarction @entity2 , with preoperative modeling of an optimal left ventricle volume. METHODS: From January 1998 to December 2000, 41 @entity0 underwent left ventricular (LV) @entity2 repair. There were 39 @entity0 and two @entity0 , with a mean age 45.6+/-6.2 years. With echocardiography study, an optimal end-diastolic volume of LV was modeled on the basis of the proper @entity1 index and the contractile ejection fraction (EF). A permissible area of @entity2 resection was calculated by using a difference between the initial and the projected surface area of LV. The patch position and sizes were measured preoperatively. Ventricular reconstruction was performed by using linear plasty in eight @entity0 , septal plasty of the Stoney et al. technique in 14 @entity0 , and endoventriculoplasty of the Dor et al. technique in 19 @entity0 . RESULTS: The mean NYHA functional class decreased from 2.9+/-0.6 to 1.6+/-0.7 postoperatively. The improvement of LV contracting function made itself evident in a decreased end-diastolic volume from 216+/-98 to 158+/-35 ml, and end-systolic volume from 133+/-85 to 80+/-34 ml postoperatively. The mean EF increased from 38+/-11 to 49+/-9% after operation. We noted that preoperative contractile EF corresponded with postoperative EF (49.8+/-11% and 49.3+/-9%, respectively). The projected optimal end-diastolic volume of LV estimated before operation agreed with postoperative data (152+/-33 ml and 158+/-35 ml, respectively). The hospital mortality rate was 7.3%. CONCLUSIONS: Preoperative modeling of an optimal LV volume allows for the estimation of a permissible area of @entity2 resection, the position and sizes of the patch, as well as for the prevention of an excessive reduction of the LV cavity after @entity2 repair.

title: Preoperative modeling of an optimal left ventricle volume for surgical treatment of XXXX .

answer: @entity2


abstract: @entity3 and changes in serum osmolarity are consequences of 0.9% @entity5 ( @entity5 ) solution administration. We sought to determine if these physiologic changes influence @entity0 outcome. @entity0 undergoing aortic reconstructive surgery were enrolled and were randomly assigned to receive lactated Ringer's (LR) solution (n = 33) or @entity5 (n = 33) in a double-blinded fashion. Anesthetic and fluid management were standardized. Multiple measures of outcome were monitored. The @entity5 @entity0 developed a hyperchloremic @entity3 and received more @entity4 therapy (30 +/- 62 mL in the @entity5 group versus 4 +/- 16 mL in the LR group; mean +/- SD), which was given if the base deficit was greater than -5 mEq/L. The @entity5 @entity0 also received a larger volume of platelet transfusion (478 +/- 302 mL in the @entity5 group versus 223 +/- 24 mL in the LR group; mean +/- SD). When all blood products were summed, the @entity5 group received significantly more blood products (P = 0.02). There were no differences in duration of mechanical ventilation, intensive care unit stay, hospital stay, and incidence of complications. When @entity5 was used as the primary intraoperative solution, significantly more @entity3 was seen on completion of surgery. This @entity3 resulted in no apparent change in outcome but required larger amounts of @entity4 to achieve predetermined measurements of base deficit and was associated with the use of larger amounts of blood products. These changes should be considered when choosing fluids for surgical procedures involving extensive @entity1 and requiring extensive fluid administration. IMPLICATIONS: Predominant use of 0.9% saline solution in major surgery has little impact on outcome as assessed by duration of mechanical ventilation, intensive care unit stay, hospital stay, and @entity2 , but it does appear to be associated with increased perioperative @entity1 .

title: Normal saline versus lactated Ringer's solution for intraoperative fluid management in XXXX undergoing abdominal aortic aneurysm repair: an outcome study.

answer: @entity0


abstract: PURPOSE: @entity0 with relapsed @entity3 have poor prognosis and short survival. Our aim was to determine the efficacy of nonablative allogeneic stem-cell transplantation in @entity0 with relapsed @entity3 . @entity0 AND METHODS: Eighteen @entity0 were treated in one of two consecutive trials. Thirteen @entity0 underwent a conditioning regimen of @entity8 (30 mg/m2 daily for 3 days), @entity1 (750 mg/m2 daily for 3 days), and high-dose rituximab. For the remaining five @entity0 , the conditioning regimen consisted of @entity2 (25 mg/m2 daily for 4 days), @entity8 (30 mg/m2 daily for 2 days), and @entity7 (1,000 mg/m2 daily for 2 days). @entity4 and @entity5 were used for graft-versus-host disease prophylaxis. RESULTS: The median age was 56.5 years. @entity0 underwent a median of three prior chemotherapy regimens. Prior autologous transplantation failed in five (28%) @entity0 and 16 (89%) had chemosensitive disease. Donor cell engraftment occurred in all @entity0 . Eight @entity0 (44%) required no platelet or RBC transfusion, and @entity6 of greater than grade 2 did not develop in any @entity0 . The day-100 mortality was 0%. Complete remission (CR) occurred in 17 @entity0 . Three @entity0 progressed, and one was reinduced into continuous CR with donor lymphocyte infusion. With a median follow-up period of 26 months, the actuarial probability of current-event-free-survival at 3 years was 82% (95% CI, 65% to 99%). CONCLUSION: Our data suggest that nonablative allogeneic transplantation is a safe and potentially effective strategy for @entity0 with relapsed and chemosensitive @entity3 .

title: Nonablative allogeneic stem-cell transplantation for advanced/recurrent XXXX .

answer: @entity3


abstract: @entity5 (CST) is a sleep-modulating peptide found exclusively in the brain. Although CST is closely related to @entity2 (SST) and binds to SST receptors, CST has effects on sleep and neuronal activity in cortex and hippocampus that differ from SST. To uncover the cellular mechanisms affected by CST, we studied the electrophysiological postsynaptic effects of CST and assessed its interaction with SST on hippocampal @entity1 pyramidal neurons. CST altered intrinsic membrane properties and occluded SST effects, indicating that both peptides similarly augment the sustained K+ M- and leak-currents (IM and IK(L)). In the presence of SST, however, CST elicited an additional inwardly rectifying component in the hyperpolarized range. This effect was unaffected by @entity3 , used to block K+ currents, but was completely prevented by the selective h-current (Ih) blocker @entity4 . CST, but not SST, selectively increased Ih in a concentration-dependent manner by augmenting its maximum conductance. CST did not shift the Ih activation curve, and the peptide effect was unaffected by a membrane-permeable analog of @entity0 . We conclude that CST and SST similarly increase K+ conductances in hippocampal neurons, most likely by activating SST receptors. However, CST additionally augments Ih, a voltage-dependent current that plays a key role in the modulation of synaptic integration and regulates oscillatory activity. Our results indicate that CST targets a specific conductance unaffected by SST to modulate cellular mechanisms implicated in sleep regulation.

title: The sleep-modulating peptide XXXX augments the h-current in hippocampal neurons.

answer: @entity5


abstract: Telomerase-deficient mutants of @entity0 can survive death by senescence by using one of two homologous recombination pathways. The @entity1 pathway amplifies the subtelomeric Y' sequences, while the @entity3 pathway amplifies the telomeric TG(1-3) repeats. Here we show that telomerase-negative cells require @entity4 (the major B-type cyclin in this organism), in association with @entity2 ( @entity2 ), to generate postsenescence survivors at a normal rate. The @entity3 pathway was more sensitive to the absence of @entity4 than the @entity1 pathway. We also report that telomerase @entity3 @entity1 triple mutants still generated postsenescence survivors. This novel @entity3 - and @entity1 -independent pathway of telomeric recombination also appeared to be controlled by @entity4 . In telomerase-positive cells, a synthetic growth defect between mutations in @entity4 and @entity3 or in its partners in the conserved MRX complex, @entity5 and @entity6 , was observed. This genetic interaction was independent of @entity5 nuclease activity but was dependent on a DNA repair function. The present data reveal an unexpected role of @entity2 / @entity4 in telomeric recombination during telomerase-independent maintenance of telomeres. They also uncover a functional interaction between @entity2 / @entity4 and MRX during the control of the mitotic cell cycle.

title: Mitotic cyclins regulate telomeric recombination in telomerase-deficient XXXX cells.

answer: @entity0


abstract: The signaling molecule @entity1 (NO) could engage multiple pathways to influence cellular function. Unraveling their relative biological importance has been difficult because it has not been possible to administer NO under the steady-state conditions that are normally axiomatic for analyzing ligand-receptor interactions and downstream signal transduction. To address this problem, we devised a chemical method for generating constant NO concentrations, derived from balancing NO release from a @entity5 donor with NO consumption by a sink. On theoretical grounds, @entity3 ( @entity3 ) was selected as the sink. The mixture additionally contained urate to convert an unwanted product of the reaction ( @entity4 ) into @entity2 ions. The method enabled NO concentrations covering the physiological range (0-100 nM) to be formed within approximately 1 s. Moreover, the concentrations were sufficiently stable over at least several minutes to be useful for biological purposes. When applied to the activation of guanylyl cyclase-coupled NO receptors, the method gave an EC50 of 1.7 nM NO for the protein purified from @entity0 lung, which is lower than estimated previously using a biological NO sink (red blood cells). The corresponding values for the alpha1beta1 and alpha2beta1 isoforms were 0.9 nM and 0.5 nM, respectively. The slopes of the concentration-response curves were more shallow than before (Hill coefficient of 1 rather than 2), questioning the need to consider the binding of more than one NO molecule for receptor activation. The discrepancies are ascribable to limitations of the earlier method. Other biological problems can readily be addressed by adaptations of the new method.

title: A new and simple method for delivering clamped XXXX concentrations in the physiological range: application to activation of guanylyl cyclase-coupled @entity1 receptors.

answer: @entity1


abstract: The signaling molecule @entity1 (NO) could engage multiple pathways to influence cellular function. Unraveling their relative biological importance has been difficult because it has not been possible to administer NO under the steady-state conditions that are normally axiomatic for analyzing ligand-receptor interactions and downstream signal transduction. To address this problem, we devised a chemical method for generating constant NO concentrations, derived from balancing NO release from a @entity5 donor with NO consumption by a sink. On theoretical grounds, @entity3 ( @entity3 ) was selected as the sink. The mixture additionally contained urate to convert an unwanted product of the reaction ( @entity4 ) into @entity2 ions. The method enabled NO concentrations covering the physiological range (0-100 nM) to be formed within approximately 1 s. Moreover, the concentrations were sufficiently stable over at least several minutes to be useful for biological purposes. When applied to the activation of guanylyl cyclase-coupled NO receptors, the method gave an EC50 of 1.7 nM NO for the protein purified from @entity0 lung, which is lower than estimated previously using a biological NO sink (red blood cells). The corresponding values for the alpha1beta1 and alpha2beta1 isoforms were 0.9 nM and 0.5 nM, respectively. The slopes of the concentration-response curves were more shallow than before (Hill coefficient of 1 rather than 2), questioning the need to consider the binding of more than one NO molecule for receptor activation. The discrepancies are ascribable to limitations of the earlier method. Other biological problems can readily be addressed by adaptations of the new method.

title: A new and simple method for delivering clamped @entity1 concentrations in the physiological range: application to activation of guanylyl cyclase-coupled XXXX receptors.

answer: @entity1


abstract: OBJECTIVES: The lack of agreement regarding assessment methods is responsible for the variability in the reported rate of occurrence of @entity4 after @entity1 . The aim of this study was to assess the sensitivity of different tests of neglect after right hemisphere @entity1 . METHODS: Two hundred and six subacute right hemisphere @entity1 @entity0 were given a test battery including a preliminary assessment of @entity3 and of visual extinction, a clinical assessment of gaze orientation and of personal neglect, and paper and pencil tests of @entity4 in the peripersonal space. @entity0 were compared with a previously reported control group. A subgroup of @entity0 (n=69) received a behavioural assessment of neglect in daily life situations. RESULTS: The most sensitive paper and pencil measure was the starting point in the cancellation task. The whole battery was more sensitive than any single test alone. About 85% of @entity0 presented some degree of neglect on at least one measure. An important finding was that behavioural assessment of neglect in daily life was more sensitive than any other single measure of neglect. Behavioural neglect was considered as moderate to severe in 36% of cases. A factorial analysis revealed that paper and pencil tests were related to two underlying factors. Dissociations were found between extrapersonal neglect, personal neglect, @entity3 , and extinction. Anatomical analyses showed that neglect was more common and severe when the posterior association cortex was damaged. CONCLUSIONS: The automatic rightward orientation bias is the most sensitive clinical measure of neglect. Behavioural assessment is more sensitive than any single paper and pencil test. The results also support the assumption that neglect is a @entity2 .

title: Sensitivity of clinical and behavioural tests of @entity4 after right hemisphere XXXX .

answer: @entity1


abstract: OBJECTIVES: The lack of agreement regarding assessment methods is responsible for the variability in the reported rate of occurrence of @entity4 after @entity1 . The aim of this study was to assess the sensitivity of different tests of neglect after right hemisphere @entity1 . METHODS: Two hundred and six subacute right hemisphere @entity1 @entity0 were given a test battery including a preliminary assessment of @entity3 and of visual extinction, a clinical assessment of gaze orientation and of personal neglect, and paper and pencil tests of @entity4 in the peripersonal space. @entity0 were compared with a previously reported control group. A subgroup of @entity0 (n=69) received a behavioural assessment of neglect in daily life situations. RESULTS: The most sensitive paper and pencil measure was the starting point in the cancellation task. The whole battery was more sensitive than any single test alone. About 85% of @entity0 presented some degree of neglect on at least one measure. An important finding was that behavioural assessment of neglect in daily life was more sensitive than any other single measure of neglect. Behavioural neglect was considered as moderate to severe in 36% of cases. A factorial analysis revealed that paper and pencil tests were related to two underlying factors. Dissociations were found between extrapersonal neglect, personal neglect, @entity3 , and extinction. Anatomical analyses showed that neglect was more common and severe when the posterior association cortex was damaged. CONCLUSIONS: The automatic rightward orientation bias is the most sensitive clinical measure of neglect. Behavioural assessment is more sensitive than any single paper and pencil test. The results also support the assumption that neglect is a @entity2 .

title: Sensitivity of clinical and behavioural tests of XXXX after right hemisphere @entity1 .

answer: @entity4


abstract: @entity14 also known as histiocytic necrotizing @entity10 is a rare cervical inflammatory @entity10 that is most commonly seen in young Asian @entity0 . It is mainly characterized by lymphadenopathy, @entity7 , @entity3 , nocturnal sweats, @entity8 , @entity4 , and @entity13 , and commonly follows a self-limited course. The differential diagnosis is challenging as many other conditions such as @entity6 , @entity1 , @entity5 and infectious lymphadenopathies can present in a similar way. We present an unusual case of @entity14 masquerading as metastatic @entity9 of the thyroid. A 30-year-old young female presented, 2 months post-partum, with complaints of @entity12 and @entity3 . A computed tomography scan showed enlarged right-sided lymph nodes and a thyroid nodule. Subsequent biopsy of a thyroid nodule revealed @entity11 and reactive @entity2 in one of the lymph nodes. She underwent an elective total thyroidectomy, central node dissection and a right modified lymph node dissection for enlarged lymph nodes. Her recovery was uneventful and the pathology report was consistent with a @entity9 of the thyroid with one lymph node positive for @entity1 and several other lymph nodes showing histiocytic necrotizing @entity10 . This coexistence of @entity14 with localized metastatic @entity11 is unusual and presents an interesting, challenging, and complex management dilemma.

title: XXXX Masquerading as Metastatic @entity9 of the Thyroid.

answer: @entity14


abstract: @entity14 also known as histiocytic necrotizing @entity10 is a rare cervical inflammatory @entity10 that is most commonly seen in young Asian @entity0 . It is mainly characterized by lymphadenopathy, @entity7 , @entity3 , nocturnal sweats, @entity8 , @entity4 , and @entity13 , and commonly follows a self-limited course. The differential diagnosis is challenging as many other conditions such as @entity6 , @entity1 , @entity5 and infectious lymphadenopathies can present in a similar way. We present an unusual case of @entity14 masquerading as metastatic @entity9 of the thyroid. A 30-year-old young female presented, 2 months post-partum, with complaints of @entity12 and @entity3 . A computed tomography scan showed enlarged right-sided lymph nodes and a thyroid nodule. Subsequent biopsy of a thyroid nodule revealed @entity11 and reactive @entity2 in one of the lymph nodes. She underwent an elective total thyroidectomy, central node dissection and a right modified lymph node dissection for enlarged lymph nodes. Her recovery was uneventful and the pathology report was consistent with a @entity9 of the thyroid with one lymph node positive for @entity1 and several other lymph nodes showing histiocytic necrotizing @entity10 . This coexistence of @entity14 with localized metastatic @entity11 is unusual and presents an interesting, challenging, and complex management dilemma.

title: @entity14 Masquerading as Metastatic XXXX of the Thyroid.

answer: @entity9


abstract: OBJECTIVE: This investigation explored the relationship of coping responses and parental history of @entity1 to task-induced blood pressure changes. MATERIALS AND METHODS: The sample consisted of 215 black college student volunteers (median age = 25.95 y). During the speaking task, @entity0 responded to standardized questions about perceptions of intra-ethnic and inter-ethnic group racism. Systolic blood pressure and diastolic blood pressure were measured via an automated blood pressure monitor. Usual ways of coping with intra-ethnic group racism were assessed with the @entity2 Scale, and parental history of @entity1 (PHH) was self-reported by @entity0 . RESULTS: Findings from the final step of hierarchical general linear models indicated that the main effect of emotion-focused coping was negatively associated with diastolic blood pressure (p = 0.02) and systolic blood pressure (p = 0.002) changes. Further, these analyses revealed that PHH interacted: (1) with the coping responses of planning (p = 0.007) and denial (p = 0.002) to predict changes in systolic blood pressure and (2) with the planning coping response to predict diastolic blood pressure changes (p = 0.02). The direction of these effects indicated that among @entity0 who were high in these coping responses, @entity0 who also had a positive PHH had larger blood pressure changes. Regression analyses also revealed that PHH interacted with the cognitive coping response (p = 0.01) to predict changes in systolic blood pressure. The direction of this effect indicated that among @entity0 who were low in this coping response, @entity0 who also had a positive PHH had larger systolic blood pressure changes. CONCLUSION: This study highlights the importance of examining the joint contribution of biological and psychosocial parameters to blood pressure reactivity in blacks.

title: Parental history of XXXX and coping responses predict blood pressure changes in black college volunteers undergoing a speaking task about perceptions of racism.

answer: @entity1


abstract: Exercise training decreases blood viscosity in athletes parallel with metabolic improvements mostly characterized by an @entity4 . @entity0 with @entity3 exhibit a host of @entity2 that may also benefit from regular training. However, the hemorheologic aspects of training in such subjects are not known and we aimed at characterizing them. SUBJECTS: Thirty-two @entity1 insulin resistant subjects were tested before and after 2 months. Twenty-one of them were trained (3x45 min/wk) at a level defined by exercise calorimetry and corresponding to the power at which lipid oxidation reaches a maximum (LIPOX(max )) and eleven served as controls. The two groups were matched for age and body mass index. There was no weight change in controls while the 2 months training period decreased weight by 2.5 kg (p<0.02). This change was totally explained by a loss in fat mass (-2.7 kg, p<0.02) while fat free mass remained unchanged. Blood rheology was unchanged in the control group while training improved plasma viscosity @entity6 (pl) (before: 1.43+/-0.03 mPa.s; after: 1.35+/-0.03 mPa.s, p<0.02). There was no change in either hematocrit, @entity5 or red cell aggregation. The balance of substrates oxidation shifted towards a higher use of lipids (point of crossover where subjects oxidize 70% @entity7 30% lipids: before 39.3+/-6.9 watts; after 70.8+/-6 watts, p<0.001; point where lipid oxidation is maximal (LIPOX(max )) before: 16.5+/-1.4 watts; after: 21.4+/-1.3 watts, p<0.001) and V(O(2max )) increased by 74% (p<0.01). Consistent with observations in athletes, the metabolic and ergometric improvements induced by training reduces @entity6 (pl) in sedentary, insulin resistant @entity0 , but at those low levels training does not appear to induce "autohemodilution" (as reflected by hematocrit) neither it improves red cell deformability or aggregation. The reliability of @entity6 (pl) as simple and unexpensive marker of efficiency of training in insulin resistant @entity0 should be further evaluated.

title: Regular exercise (3x45 min/wk) decreases plasma viscosity in sedentary XXXX , insulin resistant @entity0 parallel to an improvement in fitness and a shift in substrate oxidation balance.

answer: @entity1


abstract: Exercise training decreases blood viscosity in athletes parallel with metabolic improvements mostly characterized by an @entity4 . @entity0 with @entity3 exhibit a host of @entity2 that may also benefit from regular training. However, the hemorheologic aspects of training in such subjects are not known and we aimed at characterizing them. SUBJECTS: Thirty-two @entity1 insulin resistant subjects were tested before and after 2 months. Twenty-one of them were trained (3x45 min/wk) at a level defined by exercise calorimetry and corresponding to the power at which lipid oxidation reaches a maximum (LIPOX(max )) and eleven served as controls. The two groups were matched for age and body mass index. There was no weight change in controls while the 2 months training period decreased weight by 2.5 kg (p<0.02). This change was totally explained by a loss in fat mass (-2.7 kg, p<0.02) while fat free mass remained unchanged. Blood rheology was unchanged in the control group while training improved plasma viscosity @entity6 (pl) (before: 1.43+/-0.03 mPa.s; after: 1.35+/-0.03 mPa.s, p<0.02). There was no change in either hematocrit, @entity5 or red cell aggregation. The balance of substrates oxidation shifted towards a higher use of lipids (point of crossover where subjects oxidize 70% @entity7 30% lipids: before 39.3+/-6.9 watts; after 70.8+/-6 watts, p<0.001; point where lipid oxidation is maximal (LIPOX(max )) before: 16.5+/-1.4 watts; after: 21.4+/-1.3 watts, p<0.001) and V(O(2max )) increased by 74% (p<0.01). Consistent with observations in athletes, the metabolic and ergometric improvements induced by training reduces @entity6 (pl) in sedentary, insulin resistant @entity0 , but at those low levels training does not appear to induce "autohemodilution" (as reflected by hematocrit) neither it improves red cell deformability or aggregation. The reliability of @entity6 (pl) as simple and unexpensive marker of efficiency of training in insulin resistant @entity0 should be further evaluated.

title: Regular exercise (3x45 min/wk) decreases plasma viscosity in sedentary @entity1 , insulin resistant XXXX parallel to an improvement in fitness and a shift in substrate oxidation balance.

answer: @entity0


abstract: OBJECTIVES/HYPOTHESIS: This study examined the role of the pulsed-dye laser (PDL) at 585 nm coupled with @entity4 at therapeutic (5.0 mg/kg) and nontherapeutic (0.5 mg/kg) doses to delay the progression of @entity0 with a two-hit approach. The existing vasculature is selectively targeted by the laser, whereas @entity4 inhibits future angiogenesis. STUDY DESIGN: Randomized, prospective study in a @entity1 model. METHODS: Twenty-five athymic @entity1 were inoculated with oral @entity3 on six flank sites and randomly divided into five groups: 1) control subjects, 2) treatment with 0.5 mg/kg @entity4 ( @entity2 0.5), 3) treatment with 5.0 mg/kg @entity4 ( @entity2 5.0), 4) treatment with @entity2 0.5 + PDL, and 5) treatment with @entity2 5.0 + PDL. The PDL groups received irradiation after inoculation. The @entity4 was administered daily. The @entity0 were counted and measured for 14 days. RESULTS: The control group developed visible @entity0 in 50% of the inoculation sites at 3 days compared with 3 days ( @entity2 0.5) and 4 days ( @entity2 5.0) for the @entity4 groups and 9 days ( @entity2 0.5 + PDL) and 10 days ( @entity2 5.0 + PDL) for the laser treatment groups. There was no @entity0 growth until day 7 in the @entity2 5.0 + PDL group. The @entity0 volume was statistically different between the treatment groups. CONCLUSION: This study demonstrated the superiority of a single treatment with the PDL coupled with @entity4 to delay the progression of @entity0 when compared with treatment with @entity4 alone, thus introducing a novel strategy in @entity0 control.

title: Pulsed-dye laser and XXXX delay progression of oral squamous cell carcinoma: a @entity1 model.

answer: @entity4


abstract: OBJECTIVES/HYPOTHESIS: This study examined the role of the pulsed-dye laser (PDL) at 585 nm coupled with @entity4 at therapeutic (5.0 mg/kg) and nontherapeutic (0.5 mg/kg) doses to delay the progression of @entity0 with a two-hit approach. The existing vasculature is selectively targeted by the laser, whereas @entity4 inhibits future angiogenesis. STUDY DESIGN: Randomized, prospective study in a @entity1 model. METHODS: Twenty-five athymic @entity1 were inoculated with oral @entity3 on six flank sites and randomly divided into five groups: 1) control subjects, 2) treatment with 0.5 mg/kg @entity4 ( @entity2 0.5), 3) treatment with 5.0 mg/kg @entity4 ( @entity2 5.0), 4) treatment with @entity2 0.5 + PDL, and 5) treatment with @entity2 5.0 + PDL. The PDL groups received irradiation after inoculation. The @entity4 was administered daily. The @entity0 were counted and measured for 14 days. RESULTS: The control group developed visible @entity0 in 50% of the inoculation sites at 3 days compared with 3 days ( @entity2 0.5) and 4 days ( @entity2 5.0) for the @entity4 groups and 9 days ( @entity2 0.5 + PDL) and 10 days ( @entity2 5.0 + PDL) for the laser treatment groups. There was no @entity0 growth until day 7 in the @entity2 5.0 + PDL group. The @entity0 volume was statistically different between the treatment groups. CONCLUSION: This study demonstrated the superiority of a single treatment with the PDL coupled with @entity4 to delay the progression of @entity0 when compared with treatment with @entity4 alone, thus introducing a novel strategy in @entity0 control.

title: Pulsed-dye laser and @entity4 delay progression of oral squamous cell carcinoma: a XXXX model.

answer: @entity1


abstract: OBJECTIVE/HYPOTHESIS: To reconcile conflicting reports and opinions of the value of @entity3 studies for @entity0 undergoing tonsillectomy. STUDY DESIGN: Meta-analysis: Articles were identified by MEDLINE search, references from review articles, textbook chapter, and retrieved reports. Independent observers selected prospective trials of @entity0 undergoing tonsillectomy or adenoidectomy and tonsillectomy. Retrospective studies meeting other inclusion and exclusion criteria were included for sensitivity analyses of results. METHODS: Data were abstracted from studies for an end point of @entity1 with normal and @entity2 tests. Four prospective studies met all inclusion and exclusion criteria. These four studies were used in the data synthesis. An additional eight retrospective studies met all other criteria and were used in the sensitivity analysis. RESULTS: Pooled analysis of 3384 @entity0 revealed a rate of 3.3% (95% confidence interval [CI], 2.5%-4.1%) for post-tonsillectomy @entity1 in @entity0 with normal coagulation studies. A rate of 8.7% (95% CI, 1.5%-15.9%) was obtained for @entity1 in @entity0 with @entity2 studies. No significant rate difference in post-tonsillectomy @entity1 was demonstrated. CONCLUSION: There is no difference in the rate of post-tonsillectomy @entity1 in @entity0 with @entity2 studies as compared with @entity0 with normal coagulation studies obtained preoperatively.

title: XXXX : a meta-analysis.

answer: @entity1


abstract: BACKGROUND: @entity2 prevalence is an important determinant of the health demand that completes information provided by @entity1 incidence. Current estimations established from data for the years 1985 and 1995 can be used to establish a precise description of changing healthcare needs for @entity2 . METHOD: Prevalence estimates method were based on incidence data computed on the regional scale by the FRANCIM network and mortality data provided by INSERM. We used the relationship that exists between the net risk of @entity1 , the net risk of dying of the given @entity1 and the age-specific prevalence of @entity1 . RESULTS: In 1995, the prevalence of @entity0 who had a diagnosis of @entity2 amounted to 200 000 @entity0 . The estimated number of prevalent cases was never lower than 3500 in any region and in 7 regions this number was higher than 10 000. From 1985 to 1995, there has been an increase of 35% in the prevalence rates. CONCLUSION: The evaluation of the number of @entity0 who have had a diagnosis of @entity2 provides knowledge for health care planning. Such information on the regional scale is very useful for the health organisation (SROS). This geographical level induces difficulties not encountered at the national level.

title: [Estimate of regional prevalence of XXXX in France].

answer: @entity2


abstract: PURPOSE: To evaluate survival, @entity0 , @entity1 @entity2 , and prediction of local recurrence after percutaneous ultrasonographically (US) guided radiofrequency (RF) thermal ablation with electrodes perfused continuously with isotonic saline. MATERIALS AND METHODS: VX2 @entity4 were implanted in 31 @entity3 according to a standardized protocol. After 21 days, 16 animals were treated percutaneously with RF ablation. Four animals died of complications related to anesthesia, and 12 animals were evaluated. All animals were followed for 110 days and monitored with computed tomography (CT) and US at 1, 7, and 30 days. A control group of 15 animals did not receive treatment. Autopsy was performed at the end of scheduled follow-up or immediately after @entity5 . For survival analysis, the Kaplan-Meier method was used; for nominal data, the Fisher exact test was used. RESULTS: In comparison to controls, animals in the treatment group showed significantly prolonged survival (P <.001). Eight of 12 animals (67%) treated with RF ablation survived to 110 days, while none of the controls did so. @entity0 developed in all controls (100%) and in eight of 12 treated animals (67%) (P =.001). In comparison with controls, animals that developed @entity0 despite treatment also showed significantly prolonged survival (P =.02). Local recurrence was observed in three of 12 animals (25%) in the treatment group. CT and US performed 1 week after treatment did not allow prediction of local recurrence. CONCLUSION: RF ablation of @entity4 with perfused needle applicators prolongs survival in the VX2 @entity3 @entity4 model, regardless of whether complete remission is achieved. In comparison with controls, RF ablation results in a lower frequency of @entity0 .

title: Percutaneous US-guided radiofrequency ablation with perfused needle applicators: improved survival with the VX2 @entity1 model in XXXX .

answer: @entity3


abstract: PURPOSE: To evaluate survival, @entity0 , @entity1 @entity2 , and prediction of local recurrence after percutaneous ultrasonographically (US) guided radiofrequency (RF) thermal ablation with electrodes perfused continuously with isotonic saline. MATERIALS AND METHODS: VX2 @entity4 were implanted in 31 @entity3 according to a standardized protocol. After 21 days, 16 animals were treated percutaneously with RF ablation. Four animals died of complications related to anesthesia, and 12 animals were evaluated. All animals were followed for 110 days and monitored with computed tomography (CT) and US at 1, 7, and 30 days. A control group of 15 animals did not receive treatment. Autopsy was performed at the end of scheduled follow-up or immediately after @entity5 . For survival analysis, the Kaplan-Meier method was used; for nominal data, the Fisher exact test was used. RESULTS: In comparison to controls, animals in the treatment group showed significantly prolonged survival (P <.001). Eight of 12 animals (67%) treated with RF ablation survived to 110 days, while none of the controls did so. @entity0 developed in all controls (100%) and in eight of 12 treated animals (67%) (P =.001). In comparison with controls, animals that developed @entity0 despite treatment also showed significantly prolonged survival (P =.02). Local recurrence was observed in three of 12 animals (25%) in the treatment group. CT and US performed 1 week after treatment did not allow prediction of local recurrence. CONCLUSION: RF ablation of @entity4 with perfused needle applicators prolongs survival in the VX2 @entity3 @entity4 model, regardless of whether complete remission is achieved. In comparison with controls, RF ablation results in a lower frequency of @entity0 .

title: Percutaneous US-guided radiofrequency ablation with perfused needle applicators: improved survival with the VX2 XXXX model in @entity3 .

answer: @entity1


abstract: STUDY DESIGN: A cross-sectional survey of 806 pupils in Odense, Denmark was performed. This survey included @entity0 and adolescents ages 8 to 10 and 14 to 16 years obtained through two-stage cluster sampling from schools stratified according to school type, location, and socioeconomic character of the uptake area. OBJECTIVES: To establish the 1-month prevalence of neck, middle back, and @entity3 and the consequences this disorder may have in relation to age and gender. SUMMARY OF BACKGROUND DATA: The @entity2 and the variety of age groups included in previous studies make it difficult to draw clear conclusions about the onset of @entity1 for various spinal regions in the young. METHODS: Information on back @entity1 within the preceding month, obtained through a standardized interview of 481 @entity0 and 325 adolescents, was categorized according to area of @entity1 , age, and gender. The consequences of back @entity1 also were studied. RESULTS: The 1-month prevalence of back @entity1 was 39%. @entity1 is most common in childhood, whereas @entity1 and @entity1 are equally common in adolescence. Neck @entity1 and @entity1 in more than one area of the spine are rare in both age groups. No gender differences were found. Of those who had back @entity1 , 38% also reported some type of consequence, usually either visits to a medical physician or diminished physical activities. CONCLUSIONS: For clinical and research purposes, @entity4 , @entity2 , and @entity3 in childhood should be regarded as three specific entities. In future research the data for different age groups should be reported separately.

title: XXXX reporting pattern in a Danish population-based sample of @entity0 and adolescents.

answer: @entity2


abstract: STUDY DESIGN: A cross-sectional survey of 806 pupils in Odense, Denmark was performed. This survey included @entity0 and adolescents ages 8 to 10 and 14 to 16 years obtained through two-stage cluster sampling from schools stratified according to school type, location, and socioeconomic character of the uptake area. OBJECTIVES: To establish the 1-month prevalence of neck, middle back, and @entity3 and the consequences this disorder may have in relation to age and gender. SUMMARY OF BACKGROUND DATA: The @entity2 and the variety of age groups included in previous studies make it difficult to draw clear conclusions about the onset of @entity1 for various spinal regions in the young. METHODS: Information on back @entity1 within the preceding month, obtained through a standardized interview of 481 @entity0 and 325 adolescents, was categorized according to area of @entity1 , age, and gender. The consequences of back @entity1 also were studied. RESULTS: The 1-month prevalence of back @entity1 was 39%. @entity1 is most common in childhood, whereas @entity1 and @entity1 are equally common in adolescence. Neck @entity1 and @entity1 in more than one area of the spine are rare in both age groups. No gender differences were found. Of those who had back @entity1 , 38% also reported some type of consequence, usually either visits to a medical physician or diminished physical activities. CONCLUSIONS: For clinical and research purposes, @entity4 , @entity2 , and @entity3 in childhood should be regarded as three specific entities. In future research the data for different age groups should be reported separately.

title: @entity2 reporting pattern in a Danish population-based sample of XXXX and adolescents.

answer: @entity0


abstract: In the @entity1 , @entity3 and @entity2 are described as alarm substances. We asked whether both substances have a similar role by testing the effect of their exposure on the appetitive proboscis extension reflex and on the aversive stinging reflex. In the appetitive context of @entity0 stimulation no differences were found between @entity3 and @entity2 . Small amounts of @entity3 or @entity2 (3 microl of 1:9 dilution) yielded a response similar to that of a non-exposed control. Larger amounts of both substances (125 microl of 1:9 dilutions) as well as mixtures led to a decrease of responsiveness to @entity0 . In the aversive context of electrical stimulation, significant differences between @entity3 and @entity2 were found. Exposure to a small amount of @entity3 (3 microl of 1:9 dilution) or to a large amount of @entity2 (125 microl of 1:9 dilution) led to an increase of responsiveness to the electric shock. Larger quantities of @entity3 (125 microl of 1:9 dilution) decreased the responsiveness to the shock. @entity2 never decreased the responsiveness to the shock. Our results indicate that @entity3 and @entity2 have different functions even if both are capable of evoking deterrent responses in a defensive context.

title: Different functions of two alarm substances in the XXXX .

answer: @entity1


abstract: OBJECTIVE: There has been little research into @entity1 . While, Peji   carried out a study some 50 years ago, and Grymer more recently suggested that some @entity2 could be inherited, both studies lack a precise definition of the types of @entity2 which were investigated. The aim of this paper is to investigate the hypothetic influence of heredity on the onset of particular types of @entity2 . The authors investigated a very particular and well defined type of @entity2 after Mladina's classification. METHODS: The authors studied a group of 22 @entity0 among 779 @entity0 aged 7-14, selected at random, suffering from @entity2 and their 44 parents. They were examined by means of anterior rhinoscopy by two the same ENT specialists in rhinology. The control group consisted of 24 @entity0 with a straight nasal septum of the same age and sex distribution and their 48 parents. The results were compared using Fisher's exact probability test. RESULTS: In the studied group @entity2 was found in 21 out of 22 both fathers and mothers of these @entity0 . Type 6 was not found in any of 48 parents of @entity0 with no @entity2 . CONCLUSIONS: There is a high positive correlation between the appearance of @entity2 in both mothers and fathers of @entity0 with this @entity2 . The high correlation in the incidence of type 6 @entity2 in mothers and their @entity0 and in fathers and their @entity0 suggests that this type of @entity2 is inherited. Most authors hold that only @entity2 result from inheritance factors, while @entity2 result from environmental factors, that is, from injury to the nose and the central massif of the face. However, our study of type 6 deformities shows that certain types of @entity2 can be inherited.

title: Are some septal XXXX revisited.

answer: @entity1


abstract: OBJECTIVE: Facial nerve (FN) anomalies are exceedingly rare. The association between a @entity3 and an anomalous @entity5 has never been touched deeply in the literature. The aim of this study is to report @entity5 in @entity0 presenting with @entity3 ( @entity3 ) and/or @entity5 . METHODS: A retrospective chart review over 10 years from two academic tertiary referral centers. Eight @entity0 were diagnosed with @entity5 in association with @entity3 . The age ranged from 7 months to 13 years. RESULTS: Five @entity0 had conductive @entity3 (CCHL). Two had congenital @entity4 (CSNHL). The eighth @entity0 had a @entity3 ( @entity3 ). Surgical findings for @entity0 with conductive @entity3 included @entity5 passing @entity1 (OW) (two @entity0 ), @entity5 covering head of stapes (three @entity0 ), deformed stapes (two @entity0 ), deformed incus (two @entity0 ), and absent incus (one @entity0 ). Radiological findings for @entity0 with congenital @entity4 and @entity3 include, @entity2 (one @entity0 ), dilated vestibule and superior semicircular canal (one @entity0 ), and absent internal auditory canal (IAC) (two @entity0 ). For @entity0 with conductive @entity3 , the radiological findings consistency demonstrates a soft tissue opacification in the middle ear. CONCLUSIONS: @entity3 may be associated with @entity5 . Pediatric otolaryngologists should be cautious when exploring @entity0 with conductive @entity3 .

title: @entity5 in association with XXXX .

answer: @entity3


abstract: OBJECTIVE: Facial nerve (FN) anomalies are exceedingly rare. The association between a @entity3 and an anomalous @entity5 has never been touched deeply in the literature. The aim of this study is to report @entity5 in @entity0 presenting with @entity3 ( @entity3 ) and/or @entity5 . METHODS: A retrospective chart review over 10 years from two academic tertiary referral centers. Eight @entity0 were diagnosed with @entity5 in association with @entity3 . The age ranged from 7 months to 13 years. RESULTS: Five @entity0 had conductive @entity3 (CCHL). Two had congenital @entity4 (CSNHL). The eighth @entity0 had a @entity3 ( @entity3 ). Surgical findings for @entity0 with conductive @entity3 included @entity5 passing @entity1 (OW) (two @entity0 ), @entity5 covering head of stapes (three @entity0 ), deformed stapes (two @entity0 ), deformed incus (two @entity0 ), and absent incus (one @entity0 ). Radiological findings for @entity0 with congenital @entity4 and @entity3 include, @entity2 (one @entity0 ), dilated vestibule and superior semicircular canal (one @entity0 ), and absent internal auditory canal (IAC) (two @entity0 ). For @entity0 with conductive @entity3 , the radiological findings consistency demonstrates a soft tissue opacification in the middle ear. CONCLUSIONS: @entity3 may be associated with @entity5 . Pediatric otolaryngologists should be cautious when exploring @entity0 with conductive @entity3 .

title: XXXX in association with @entity3 .

answer: @entity5


abstract: The object of this report is to review the clinical outcomes of aortic valve-sparing operations in @entity0 with @entity4 . From May 1988 to June 2000, 120 @entity0 with @entity4 with or without @entity2 underwent aortic valve-sparing operations. There were 83 @entity0 and 37 @entity0 whose mean age was 46 years (range 16 to 72 years). Forty-eight @entity0 had the @entity7 , and 22 had either @entity9 . Reconstruction of the aortic root was performed using the technique of reimplanation of the aortic valve in 64 @entity0 and the remodeling of the aortic root in 56. The mean follow-up was 35 months (range 2 to 145 months), and it was complete. Aortic valve function was assessed by echocardiography. There were 2 operative and 5 late deaths. The 10-year survival for @entity0 with @entity4 was 88% +/- 4%. Two @entity0 have required aortic root replacement: one on the first postoperative day because of severe @entity2 and one paraplegic @entity0 12 years after surgery because of @entity5 with @entity8 . Both @entity0 survived reoperation. The 10-year freedom from aortic root reoperation was 99% +/- 1%. Three @entity0 suffered transient @entity1 attacks. The 10-year freedom from @entity6 events was 89% +/- 5%. Seven @entity0 had moderate @entity2 at the latest echocardiographic study. The 10-year freedom from severe or moderate @entity2 was 83% +/- 8%. Aortic valve-sparing operations have provided excellent clinical outcomes and few @entity3 . The function of the reconstructed aortic root remains unchanged in most @entity0 during the first decade of follow-up.

title: Aortic valve-sparing operations for XXXX .

answer: @entity4


abstract: OBJECTIVE: To compare the inspiratory volume pressure (VP) curves of the respiratory system (rs) produced by static occlusion (OCC) and dynamic low constant flow inflation (LCFI) methods using a new device in @entity1 ( @entity1 ) @entity0 . SETTING: A multidisciplinary 24-bed ICU in a tertiary university hospital. @entity0 : Eleven intubated and mechanically ventilated @entity0 with @entity1 . MEASUREMENTS AND RESULTS: OCC and LCFI methods were performed using the same ventilator, which had been specifically implemented for this purpose. LCFI of 5, 10, and 15 l/min and OCC were applied in a random order at zero end-expiratory positive pressure. Airway pressure was measured both proximal (P(ao)) and distal (P(tr)) to the endotracheal tube. @entity2 ( @entity2 ) and maximal slope (C(max,rs)) were estimated using unbiased iterative linear regressions. @entity2 (rs) was obtained in all @entity0 under LCFI and in nine @entity0 under OCC. With LCFI of 5, 10, 15 l/min and OCC the average @entity2 (rs) values were 12.2 +/- 3.9, 12.9 +/- 4, 14.3 +/- 3.4, and 11.9 cm @entity3 for P(ao) and 11.9 +/- 3.9, 11.5 +/- 3.3, 12.5 +/- 3.4 and 11.8 +/- 4.4 for P(tr), respectively. Only the mean values of @entity2 (rs) for P(ao) with LCFI at 15 l/min were significantly different from those obtained for OCC. The C(max,rs) values found with the two methods were similar. CONCLUSIONS: An LCFI less than or equal to 10 l/min seems to be a quick, safe, and reliable method to determine @entity2 (rs) and C(max,rs) at the bedside.

title: Inspiratory pressure-volume curves obtained using automated low constant flow inflation and automated occlusion methods in XXXX @entity0 with a new device.

answer: @entity1


abstract: OBJECTIVE: To compare the inspiratory volume pressure (VP) curves of the respiratory system (rs) produced by static occlusion (OCC) and dynamic low constant flow inflation (LCFI) methods using a new device in @entity1 ( @entity1 ) @entity0 . SETTING: A multidisciplinary 24-bed ICU in a tertiary university hospital. @entity0 : Eleven intubated and mechanically ventilated @entity0 with @entity1 . MEASUREMENTS AND RESULTS: OCC and LCFI methods were performed using the same ventilator, which had been specifically implemented for this purpose. LCFI of 5, 10, and 15 l/min and OCC were applied in a random order at zero end-expiratory positive pressure. Airway pressure was measured both proximal (P(ao)) and distal (P(tr)) to the endotracheal tube. @entity2 ( @entity2 ) and maximal slope (C(max,rs)) were estimated using unbiased iterative linear regressions. @entity2 (rs) was obtained in all @entity0 under LCFI and in nine @entity0 under OCC. With LCFI of 5, 10, 15 l/min and OCC the average @entity2 (rs) values were 12.2 +/- 3.9, 12.9 +/- 4, 14.3 +/- 3.4, and 11.9 cm @entity3 for P(ao) and 11.9 +/- 3.9, 11.5 +/- 3.3, 12.5 +/- 3.4 and 11.8 +/- 4.4 for P(tr), respectively. Only the mean values of @entity2 (rs) for P(ao) with LCFI at 15 l/min were significantly different from those obtained for OCC. The C(max,rs) values found with the two methods were similar. CONCLUSIONS: An LCFI less than or equal to 10 l/min seems to be a quick, safe, and reliable method to determine @entity2 (rs) and C(max,rs) at the bedside.

title: Inspiratory pressure-volume curves obtained using automated low constant flow inflation and automated occlusion methods in @entity1 XXXX with a new device.

answer: @entity0


abstract: BACKGROUND: To evaluate outcome and prognostic factors in Saudi Arabian @entity0 with metastatic @entity2 and @entity3 of bone (PMES) at diagnosis. PROCEDURE: Ninety-nine of 304 (33%) consecutive @entity0 with @entity2 and @entity3 of bone registered at our centre from 1975 to 1998, had metastatic disease at registration and 93 were available for analysis. The maximum x-axis diameter of the @entity1 was used as the measure of @entity1 size. Usually a trial of systemic treatment was undertaken before a decision was made on local treatment. Standard chemotherapy regimens were used in all treated @entity0 . Forty-one (44%) @entity0 did not receive radical local treatment due to an inadequate response to chemotherapy, or a decision not to undertake more than palliative treatment. Radical treatment of the primary site was radiation alone 41 (79%), resection alone 7 (13%), and resection and radiation 4 (8%). RESULTS: The 5-year survival rates were 9% for all 93 evaluable @entity0 , 16% for 52 @entity0 who received chemotherapy and radical local treatment, 0% for 41 @entity0 who received lesser treatment, 19% for 43 @entity0 with lung metastases alone, and 0% (P = 0.002) for 50 @entity0 with other sites involved. For 60 @entity0 with imaging data, 5-year survivals were 34 and 0% when the maximum transverse diameter of the @entity1 was < 10 cm (N = 20) and > or = 10 cm (N = 40), respectively. CONCLUSIONS: Small @entity1 size and the presence of lung metastases alone were the only significant favorable prognostic factors. Earlier diagnosis will be the basis for better results.

title: Metastatic @entity2 / XXXX of bone at diagnosis: prognostic factors--a report from Saudi Arabia.

answer: @entity3


abstract: BACKGROUND: To evaluate outcome and prognostic factors in Saudi Arabian @entity0 with metastatic @entity2 and @entity3 of bone (PMES) at diagnosis. PROCEDURE: Ninety-nine of 304 (33%) consecutive @entity0 with @entity2 and @entity3 of bone registered at our centre from 1975 to 1998, had metastatic disease at registration and 93 were available for analysis. The maximum x-axis diameter of the @entity1 was used as the measure of @entity1 size. Usually a trial of systemic treatment was undertaken before a decision was made on local treatment. Standard chemotherapy regimens were used in all treated @entity0 . Forty-one (44%) @entity0 did not receive radical local treatment due to an inadequate response to chemotherapy, or a decision not to undertake more than palliative treatment. Radical treatment of the primary site was radiation alone 41 (79%), resection alone 7 (13%), and resection and radiation 4 (8%). RESULTS: The 5-year survival rates were 9% for all 93 evaluable @entity0 , 16% for 52 @entity0 who received chemotherapy and radical local treatment, 0% for 41 @entity0 who received lesser treatment, 19% for 43 @entity0 with lung metastases alone, and 0% (P = 0.002) for 50 @entity0 with other sites involved. For 60 @entity0 with imaging data, 5-year survivals were 34 and 0% when the maximum transverse diameter of the @entity1 was < 10 cm (N = 20) and > or = 10 cm (N = 40), respectively. CONCLUSIONS: Small @entity1 size and the presence of lung metastases alone were the only significant favorable prognostic factors. Earlier diagnosis will be the basis for better results.

title: Metastatic XXXX / @entity3 of bone at diagnosis: prognostic factors--a report from Saudi Arabia.

answer: @entity2


abstract: PURPOSE: Examination of the aetiology, clinical characteristics and the final results for contusion @entity1 of the eyeball. MATERIAL AND METHODS: Retrospective examination of the clinical documentation for 247 @entity0 (260 eyes of which 219 male and 41 female), treated in Emergency Eye Clinic during the period 1994-1996. The @entity0 are separated in groups by their age. DISCUSSION AND RESULTS: Contusion @entity1 are more frequent in @entity0 and @entity0 aged up to 50 years old. The @entity1 are caused by different factors but these having housework and criminal character prevail. The eyeball is with not damaged entity in 225 eyes (86.54%) and with damaged entity in 35 eyes (13.46%). @entity2 are observed in 11 @entity0 . The clinical characteristics show simultaneous injury of the front protection elements and the eyeball. More often all tissues and areas of the eye are damaged. Serious damages in the area of iris-lens diaphragm, vitreous and retina are observed. The final visual acuity in 178 eyes (68.48%) is between 20/40 and 20/20. CONCLUSION: The contusion @entity1 are more frequent in @entity0 and young @entity0 . The @entity1 caused by factors having housework and criminal character prevail. Usually all tissues and areas of the eye are damaged. The final visual acuity of the most of the eyes is between 20/40 and 20/20.

title: [Contusion eye XXXX : etiology, clinical characteristics and final results].

answer: @entity1


abstract: OBJECTIVE: Post-movement beta synchronization is an increase in EEG beta power after movement termination. Its characteristics in @entity4 are not well described. @entity1 shows unique clinical, anatomical and biochemical features. In our study we examined the relation between the laterality of @entity3 and size of post-movement beta synchronisation in @entity3 dominant @entity1 . METHODS: In a self-paced movement paradigm we measured movement duration and analyzed EEG power changes at movement-reactive beta frequencies. RESULTS: Movement duration was significantly longer in @entity2 - @entity0 than in controls (0.49 +/- 0.170 s, 0.35 +/- 0.087 s, p = 0.013, Mann-Whitney test). There was no difference between the two hands in the control group (0.36 +/- 0.078 s, 0.34 +/- 0.099 s, p = 0.207, Wilcoxon-test), while @entity2 @entity0 performed longer movement with their left hand (0.52 +/- 0.195 s, 0.46 +/- 0.148 s, p = 0.049, Wilcoxon), unrelated to the side of @entity3 . In controls, post-movement beta synchronisation contralateral to the movement was not significantly different after right and left hand movement (108.1 +/- 68.21% and 92.1 +/- 23.43%, p = 0.78 Wilcoxon). In @entity2 @entity0 post-movement beta synchronisation was significantly smaller contralateral to the @entity4 (36.9 +/- 47.79%, 104.7 +/- 91.42%, p = 0.012, Wilcoxon-test). The post-movement beta synchronisation showed anterior shifting in @entity2 - @entity0 . CONCLUSIONS: In @entity3 dominant @entity1 the asymmetric decrease of post-move beta synchronisation is related to the laterality of @entity3 rather than @entity5 . Analysis of this phenomena might provide further insight to the pathophysiology of @entity1 .

title: [Electrophysiologic investigation of cerebral cortex in the subtypes of XXXX ].

answer: @entity1


abstract: AIM OF THE STUDY: To report our experience of total pancreatectomy (TP) in ten @entity0 with mucinous @entity4 (MPT), to discuss pre and peroperative investigations in the management of MPT, and operative, functional and carcinologic results after TP. @entity0 AND METHODS: This retrospective study from January 1985 to January 2001 included ten @entity0 , 5 @entity0 and 5 @entity0 (mean aged: 64 years). Six @entity0 underwent one step TP for @entity1 ( @entity1 ) in 5 cases, and multifocal @entity6 in one case. Four @entity0 underwent a second step TP for @entity1 recurrence (2 @entity1 , and 2 @entity5 ) which occurred 12 to 121 months post operatively (mean: 49 months). RESULTS: Post TP @entity2 was controlled by insulinotherapy (3 injections a day), except in one @entity0 who needed insulin administration through a pump. One @entity0 , with @entity5 , died from @entity1 recurrence 18 months after TP and 140 months after the initial pancreaticoduodenectomy. One @entity0 died from @entity3 34 months postoperatively. The 8 other @entity0 were alive with a mean follow-up of 33 months (range 11-61 months). CONCLUSION: Curative surgery for mucinous @entity1 of the pancreas may require TP, which is indicated preoperatively according to imaging, or intraoperatively following surgical findings and frozen section of the pancreatic margin. Totalization of a previous partial pancreatectomy is mandatory in case of @entity1 persistence or recurrence in the pancreatic remnant. @entity2 can be managed successfully by a specialized team.

title: [Total pancreatectomy for mucinous XXXX ].

answer: @entity4


abstract: OBJECTIVES: In the primary treatment of @entity0 , postoperative radiotherapy is performed in high-risk @entity1 after mastectomy and in @entity1 who received breast conserving surgery. In a retrospective analysis, our mono-institutional results of postoperative irradiation have been evaluated. @entity1 AND METHODS: Between 1992 and 1996, 500 @entity1 have been irradiated after surgery for primary @entity0 . Of these, 489 @entity1 had no initial metastases. 89 @entity1 with loco-regional disease had a mastectomy, 400 @entity1 were irradiated after breast conserving surgery. Radiotherapy at the chest wall was performed with 50 Gy and 2 Gy fractions. After microscopically incomplete resection, an electron boost of 10 Gy was given. The ipsilateral lymph nodes were irradiated with 50 Gy when there was extensive lymph node involvement or invasion of @entity2 in the axillary fat tissue. RESULTS: The 5-year local control rate after mastectomy was 97.4% and 91.2% after breast conserving surgery. The only statistically significant risk factor for local failure was microscopically incomplete resection. The corresponding 5-year local control rates for microscopically incomplete and complete resections were 76.4% and 92.7% (p = 0.01). The risk of local relapse was increased with both marginal invasive and marginal DCIS-tissue. 86.6% of local relapses were in the same quadrant. CONCLUSIONS: High-risk @entity1 after mastectomy and @entity1 with breast conserving surgery achieve a high local control rate with postoperative irradiation. After microscopically incomplete resection, there is an increased risk for local relapse.

title: Microscopic residual disease is a risk factor in the primary treatment of XXXX .

answer: @entity0


abstract: DnaK is essential for starvation-induced resistance to heat, oxidation, and reductive division in @entity2 . Studies reported here indicate that DnaK is also required for starvation-induced osmotolerance, catalase activity, and the production of the RpoS-controlled Dps (PexB) protein. Because these dnaK mutant phenotypes closely resemble those of rpoS (sigma38) mutants, the relationship between DnaK and RpoS was evaluated directly during growth and starvation at 30 degrees C in strains with genetically altered DnaK content. A starvation-specific effect of DnaK on RpoS abundance was observed. During @entity1 starvation, @entity3 reduced RpoS levels threefold, while DnaK excess increased RpoS levels nearly twofold. Complementation of the dnaK mutation restored starvation-induced RpoS levels to normal. @entity3 had no effect on the cellular concentration of DnaK, revealing an epistatic relationship between DnaK and RpoS. Protein half-life studies conducted at the onset of starvation indicate that @entity3 significantly destabilized RpoS. RpoH (sigma32) suppressors of the dnaK mutant with restored levels of RpoS and dnaK rpoS double mutants were used to show that DnaK plays both an independent and an RpoS-dependent role in starvation-induced thermotolerance. The results suggest that DnaK coordinates sigma factor levels in @entity0 -starved @entity2 .

title: Roles of DnaK and RpoS in starvation-induced thermotolerance of XXXX .

answer: @entity2


abstract: INTRODUCTION: @entity4 of the spine (SEHS) is an extremely rare entity. @entity0 known to have @entity1 or on anticoagulant drugs are the most affected. It is generally caused by a @entity3 plexus secondary to minor @entity6 such as cough, peridural catheter insertion... Early diagnosis and treatment showed to have the best outcome. CASES REPORT: We report 3 cases of spontaneous @entity4 in @entity0 treated by @entity5 , which occurred without any provocative factor. All 3 @entity0 were treated with decompressive laminectomy. DISCUSSION: We described the MRI findings and discussed the spontaneity of the entity. Our present case studies and the review of the literature showed that early diagnosis and management of SEHS can lead to improvement of the neurological state and avoid definitive motor and sensitive deficit. CONCLUSION: This rare entity should be suspected in every acute medullary syndrome with @entity2 . In order to decrease the sequelae, neurologically unstable @entity0 should benefit from early diagnosis and urgent surgical decompression.

title: XXXX of the spine associated with oral anticoagulants: 3 Case Studies.

answer: @entity4


abstract: OBJECTIVES: To study the clinicopathological and immunohistochemical features of @entity4 ( @entity4 ) in Kuwait. MATERIALS AND METHODS: @entity5 - and eosin-stained sections of primary @entity2 were reviewed. Immunohistochemical staining was performed using a panel of antibodies to determine muscle and neural differentiation, the incidence of @entity7 and @entity6 expression, as well as @entity3 and cytokeratin expression. Each stain was interpreted as negative or positive. The staining intensity of positive cases was graded as weak, moderate or strong. RESULTS: The age range was 25-80 with an average age of 54 and a male:female ratio of 3:2. The stomach was the most common site for these @entity1 , followed by the small intestine. Histologically, 46% were classified as malignant and 54% were benign. Most of the @entity1 occurred in males, particularly in the stomach or small intestine. There was no significant difference in @entity0 age between @entity1 . The most sensitive markers were muscle-specific actin for muscle differentiation and glial fibrillary acidic protein for neural differentiation. @entity7 expression was seen in 81% and @entity6 in 54% of all @entity1 . CONCLUSIONS: The results of this study show that the stomach is the most common site for these @entity1 , that @entity1 are more likely to occur in the small intestine than in the stomach, and that there is no difference between benign and @entity1 with regard to age. Our findings are comparable to those of other workers, although our male:female ratio was slightly higher.

title: XXXX : clinicopathological and immunohistochemical features.

answer: @entity4


abstract: @entity3 with the characteristic features of @entity4 ( @entity4 ) occasionally develops in @entity0 with @entity5 ( @entity5 ), and has been called @entity6 with @entity4 features. In such cases, large @entity1 cells have the morphological and immunophenotypic features of classical Hodgkin and Reed-Sternberg (H-RS) cells. However, it is not known whether the H-RS cells arise from transformation of the underlying @entity5 cells or from a different pathological process. We report herein a study of the clonal relationship between the @entity5 cells and the H-RS cells in three cases of @entity6 with @entity4 features by using a single cell assay. We isolated single @entity5 cells and H-RS cells from immunostained tissue sections by micromanipulation. The @entity7 ( @entity7 ) complementarity determining region (CDR) III of each cell was amplified by the polymerase chain reaction (PCR). The products were then compared by gel electrophoresis and @entity2 sequencing. The @entity7 CDRIII sequences from the H-RS cells were identical to those from the @entity5 cells in two cases. In one case, the clonal relationship between the two types of cells could not be determined because PCR products could not be obtained from any of the H-RS cells. This study shows that the H-RS cells and the @entity5 cells belong to the same clonal population in some cases of @entity6 with @entity4 features. Furthermore, our findings indicate that mature B cells can undergo transformation to cells with the features of H-RS cells, in association with a cellular background typical of @entity4 . This study also supports recent findings suggesting that the H-RS cells in classical @entity4 are derived from transformed B cells.

title: Origin of the Hodgkin/Reed-Sternberg cells in XXXX with "Hodgkin's transformation".

answer: @entity5


abstract: PURPOSE: @entity3 leads to @entity2 and subsequent decreases in contractile function in vivo and in vitro. We determined whether there were regional differences in bladder wall properties and in vitro contractile responses after 2 weeks of @entity3 . MATERIALS AND METHODS: Male @entity0 underwent cystometry. The bladder was then filled to 40 ml. and the surface was marked with 2-zero silk knots placed approximately 1 cm. apart. The distance between the knots was measured at 20, 40 and 80 ml. The animals then underwent the creation of surgical obstruction. After 2 weeks the obstruction was removed. Cystometry and measurements were repeated and strips were obtained from defined dorsal and ventral areas. Contractile responses to electrical field stimulation, @entity1 , @entity5 and @entity4 were determined and compared with strips from unobstructed controls. RESULTS: In vivo expansion during @entity2 occurred evenly throughout the bladder wall in controls and the contractile response to all stimuli was similar in ventral and dorsal strips. After 2 weeks of @entity3 the upper dome expanded to a significantly higher degree than the lower bladder body. The response to all stimuli was significantly reduced after @entity3 and there was a significantly decreased response to all stimuli in dorsal compared with ventral strips. Strips from the dorsal midline showed a relaxation response to electrical field stimulation at low frequencies, whereas all ventral strips contracted. CONCLUSIONS: Functional remodeling after @entity3 is a process that does not occur to the same extent throughout the bladder. The obstructed bladder is an inhomogeneous organ with significant regional differences in mechanical and pharmacological properties.

title: Regional differences in @entity2 and in vitro contractility after outlet obstruction in the XXXX .

answer: @entity0


abstract: PURPOSE: @entity3 leads to @entity2 and subsequent decreases in contractile function in vivo and in vitro. We determined whether there were regional differences in bladder wall properties and in vitro contractile responses after 2 weeks of @entity3 . MATERIALS AND METHODS: Male @entity0 underwent cystometry. The bladder was then filled to 40 ml. and the surface was marked with 2-zero silk knots placed approximately 1 cm. apart. The distance between the knots was measured at 20, 40 and 80 ml. The animals then underwent the creation of surgical obstruction. After 2 weeks the obstruction was removed. Cystometry and measurements were repeated and strips were obtained from defined dorsal and ventral areas. Contractile responses to electrical field stimulation, @entity1 , @entity5 and @entity4 were determined and compared with strips from unobstructed controls. RESULTS: In vivo expansion during @entity2 occurred evenly throughout the bladder wall in controls and the contractile response to all stimuli was similar in ventral and dorsal strips. After 2 weeks of @entity3 the upper dome expanded to a significantly higher degree than the lower bladder body. The response to all stimuli was significantly reduced after @entity3 and there was a significantly decreased response to all stimuli in dorsal compared with ventral strips. Strips from the dorsal midline showed a relaxation response to electrical field stimulation at low frequencies, whereas all ventral strips contracted. CONCLUSIONS: Functional remodeling after @entity3 is a process that does not occur to the same extent throughout the bladder. The obstructed bladder is an inhomogeneous organ with significant regional differences in mechanical and pharmacological properties.

title: Regional differences in XXXX and in vitro contractility after outlet obstruction in the @entity0 .

answer: @entity2


abstract: AIM: To investigate the relationship between sense of coherence, @entity7 and health related quality of life in @entity1 ( @entity1 ). METHODS: This cross-sectional study enrolled a consecutive sample of 147 @entity1 (aged 45.1    14.1 years; 57.1% female) @entity0 recruited from a tertiary gastroenterology service. Sixty-four @entity0 met diagnostic criteria for @entity2 , while eighty-three @entity0 had @entity3 . Socio-demographic data (education, age, race, gender, gross monthly income and marital status), disease-related variables (illness activity, relapse rate in past 2 years, history of surgery and time since diagnosis), sense of coherence (Antonovsky's SOC scale), @entity8 ( @entity4 and @entity6 Scale) and @entity5 ( @entity5 ; WHOQOL-Bref) were assessed. Hierarchical multiple regression analyses were performed to identify factors that are independently associated with @entity7 and @entity5 in @entity0 with @entity1 and to provide indications for possible moderating or mediating effects. In addition, formal moderation and mediation analyses (Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC, @entity8 . RESULTS: Lower SOC scores (std beta= -0.504; P < 0.001), female gender (std beta = 0.176; P = 0.021) and White race (std beta = 0.164; P = 0.033) were independently associated with higher levels of @entity6 , while lower levels of SOC (std beta = -0.438; P < 0.001) and higher relapse rate (std beta = 0.161; P = 0.033) were independently associated with more severe @entity4 . A significant interaction between time since diagnosis and SOC was found with regard to the severity of @entity6 or @entity4 , as the interaction term (time since diagnosis X SOC) had beta coefficients of -0.191 (P = 0.009) and -0.172 (P = 0.026), respectively. Lower levels of @entity4 (std beta = -0.369; P < 0.001), higher levels of SOC (std beta = 0.231; P = 0.016) and non-White race (std beta = -0.229; P = 0.006), i.e., mixed-race, which represented the reference category, were independently associated with higher levels of overall @entity5 . @entity4 symptoms were the most potent independent correlate of most aspects of @entity5 . In addition, @entity4 mediated the association between SOC and satisfaction with health, as well as its relationship with physical, mental, and social relations @entity5 . @entity6 also mediated the association between SOC and mental @entity5 . CONCLUSION: Our data indicated that SOC is an important construct, as it influences @entity7 and has significant albeit indirect effects on several @entity5 domains in @entity1 .

title: Associations of sense of coherence with XXXX and quality of life in @entity1 .

answer: @entity7


abstract: AIM: To investigate the relationship between sense of coherence, @entity7 and health related quality of life in @entity1 ( @entity1 ). METHODS: This cross-sectional study enrolled a consecutive sample of 147 @entity1 (aged 45.1    14.1 years; 57.1% female) @entity0 recruited from a tertiary gastroenterology service. Sixty-four @entity0 met diagnostic criteria for @entity2 , while eighty-three @entity0 had @entity3 . Socio-demographic data (education, age, race, gender, gross monthly income and marital status), disease-related variables (illness activity, relapse rate in past 2 years, history of surgery and time since diagnosis), sense of coherence (Antonovsky's SOC scale), @entity8 ( @entity4 and @entity6 Scale) and @entity5 ( @entity5 ; WHOQOL-Bref) were assessed. Hierarchical multiple regression analyses were performed to identify factors that are independently associated with @entity7 and @entity5 in @entity0 with @entity1 and to provide indications for possible moderating or mediating effects. In addition, formal moderation and mediation analyses (Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC, @entity8 . RESULTS: Lower SOC scores (std beta= -0.504; P < 0.001), female gender (std beta = 0.176; P = 0.021) and White race (std beta = 0.164; P = 0.033) were independently associated with higher levels of @entity6 , while lower levels of SOC (std beta = -0.438; P < 0.001) and higher relapse rate (std beta = 0.161; P = 0.033) were independently associated with more severe @entity4 . A significant interaction between time since diagnosis and SOC was found with regard to the severity of @entity6 or @entity4 , as the interaction term (time since diagnosis X SOC) had beta coefficients of -0.191 (P = 0.009) and -0.172 (P = 0.026), respectively. Lower levels of @entity4 (std beta = -0.369; P < 0.001), higher levels of SOC (std beta = 0.231; P = 0.016) and non-White race (std beta = -0.229; P = 0.006), i.e., mixed-race, which represented the reference category, were independently associated with higher levels of overall @entity5 . @entity4 symptoms were the most potent independent correlate of most aspects of @entity5 . In addition, @entity4 mediated the association between SOC and satisfaction with health, as well as its relationship with physical, mental, and social relations @entity5 . @entity6 also mediated the association between SOC and mental @entity5 . CONCLUSION: Our data indicated that SOC is an important construct, as it influences @entity7 and has significant albeit indirect effects on several @entity5 domains in @entity1 .

title: Associations of sense of coherence with @entity7 and quality of life in XXXX .

answer: @entity1


abstract: It has been estimated that more than 30 million of @entity0 suffer from the symptoms in the lower urinary tract caused by @entity1 . According to data from literature the term @entity1 should be reserved only for histological diagnosis. The paper presents contemporary approaches to diagnostics and non-surgical, i.e. conservative modalities of the therapy. These modalities include: follow up of the @entity0 , medicamentous therapy and non-surgical invasive therapies. Medicamentous therapy implies phytotherapy, inhibitors of @entity2 and antagonists of Alpha-adrenergic receptors. Non-surgical invasive therapies include: balloon dilatation, ureteral stents and thermotherapy. The paper indicates the place of certain options related to the conservative treatment of @entity1 . A fact that only 10% of these @entity0 are treated surgically means that majority of them need other, i.e. conservative therapy. New achievements in the treatment of @entity1 have aroused new hope for @entity0 suffering from this disease.

title: [Modern approach to conservative treatment of XXXX ].

answer: @entity1


abstract: BACKGROUND: The increased health risks associated with @entity2 have been found to occur in Asians at lower body mass indices (BMIs). To determine the optimal cut-off values for overweight or @entity2 in Taiwan, we examined the relationships between four anthropometric indices and @entity3 factors. METHODS: The data were collected from four health-screening centers from 1998 to 2000 in Taiwan. Included were 55 563 subjects (26 359 @entity0 and 29 204 @entity0 , mean age=37.3+/-10.9 and 37.0+/-11.1 y, respectively). None had known major @entity6 or were taking medication. Individual body weight, height, waist circumference (WC), and a series of tests related to @entity3 (blood pressure, fasting plasma @entity7 , @entity8 , total @entity5 , low- and high-density lipoprotein @entity5 ) were assessed and their relationships were examined. Receiver operating characteristic (ROC) analysis was used to find out the optimal cut-off values of various anthropometric indices to predict @entity4 , @entity1 and @entity9 . RESULTS: Of the four anthropometric indices we studied, waist-to-height ratio (WHtR) in @entity0 was found to have the largest areas under the ROC curve ( @entity0 =0.755, 95% CI 0.748-0.763) relative to at least one risk factor (ie @entity4 or @entity1 or @entity9 ). The optimal cut-off values for overweight or @entity2 from our study in @entity0 and @entity0 showed that BMIs of 23.6 and 22.1 kg/m(2), WCs of 80.5 and 71.5 cm, waist-to-hip ratios (WHpR) of 0.85 and 0.76, and WHtR of 0.48 and 0.45, respectively, may be more appropriate in Taiwan. CONCLUSIONS: WHtR may be a better indicator for screening overweight- or @entity2 -related CVD risk factors than the other three indexes (BMI, WC and WHpR) in Taiwan. Our study also supported the hypothesis that the cut-off values using BMI and WC to define @entity2 should be much lower in Taiwan than in Western countries.

title: Optimal cut-off values for @entity2 : using simple anthropometric indices to predict XXXX factors in Taiwan.

answer: @entity3


abstract: BACKGROUND: The increased health risks associated with @entity2 have been found to occur in Asians at lower body mass indices (BMIs). To determine the optimal cut-off values for overweight or @entity2 in Taiwan, we examined the relationships between four anthropometric indices and @entity3 factors. METHODS: The data were collected from four health-screening centers from 1998 to 2000 in Taiwan. Included were 55 563 subjects (26 359 @entity0 and 29 204 @entity0 , mean age=37.3+/-10.9 and 37.0+/-11.1 y, respectively). None had known major @entity6 or were taking medication. Individual body weight, height, waist circumference (WC), and a series of tests related to @entity3 (blood pressure, fasting plasma @entity7 , @entity8 , total @entity5 , low- and high-density lipoprotein @entity5 ) were assessed and their relationships were examined. Receiver operating characteristic (ROC) analysis was used to find out the optimal cut-off values of various anthropometric indices to predict @entity4 , @entity1 and @entity9 . RESULTS: Of the four anthropometric indices we studied, waist-to-height ratio (WHtR) in @entity0 was found to have the largest areas under the ROC curve ( @entity0 =0.755, 95% CI 0.748-0.763) relative to at least one risk factor (ie @entity4 or @entity1 or @entity9 ). The optimal cut-off values for overweight or @entity2 from our study in @entity0 and @entity0 showed that BMIs of 23.6 and 22.1 kg/m(2), WCs of 80.5 and 71.5 cm, waist-to-hip ratios (WHpR) of 0.85 and 0.76, and WHtR of 0.48 and 0.45, respectively, may be more appropriate in Taiwan. CONCLUSIONS: WHtR may be a better indicator for screening overweight- or @entity2 -related CVD risk factors than the other three indexes (BMI, WC and WHpR) in Taiwan. Our study also supported the hypothesis that the cut-off values using BMI and WC to define @entity2 should be much lower in Taiwan than in Western countries.

title: Optimal cut-off values for XXXX : using simple anthropometric indices to predict @entity3 factors in Taiwan.

answer: @entity2


abstract: BACKGROUND: Intrahepatic biliary mucinous @entity1 are rare @entity4 and account for less than 5% of @entity7 . Accurate preoperative diagnosis is difficult and the outcome differs among various treatment modalities.The aim of this study is to investigate the clinico-radiological characteristics of @entity6 and to establish eligible diagnostic and treatment suggestions. METHODS: Nineteen @entity0 with intrahepatic @entity9 and two @entity0 with @entity8 were retrospectively reviewed. Their clinico-radiological variables and survival outcome were analyzed. RESULTS: Of the 19 @entity0 with @entity9 , 16 (84.2  %) were female. 11 (57.9  %) @entity0 had symptoms before operation with the most common presenting symptom being @entity5 . Among the @entity0 with available data, serum and cystic fluid CA 19-9 levels were invariably elevated and the CA 19-9 level in the cystic fluid was significantly higher than that in the serum. Loculations (84.2  %) and septations (63.2  %) were the most common radiologic findings. For treatment, 11 (57.9  %) @entity0 received radical resection by either enucleation or hepatic resection, while the remaining 8 (42.1  %) @entity0 underwent only fenestration of @entity3 . Radical resection provided a significantly better clinical outcome than fenestration in terms of @entity1 recurrence (p   =   0.018). The only two male @entity0 with @entity8 received radical hepatic resection and achieved a @entity2 .5  months and 33  months, respectively. CONCLUSION: Intrahepatic biliary mucinous @entity1 are rare and preoperative diagnosis is difficult. Internal septations and loculations on radiologic examinations should raise some suspicion of this diagnosis. Complete @entity1 excision is the standard treatment that may provide @entity0 with better long term results after the operation.

title: Intrahepatic biliary mucinous XXXX : clinicoradiological characteristics and surgical results.

answer: @entity1


abstract: UNASSIGNED: Aging leads to a gradual decline in the fidelity of cerebral blood flow (CBF) responses to neuronal activation, resulting in an increased risk for @entity1 and @entity3 . However, it is currently unknown when age-related @entity4 starts or which vascular components and functions are first affected. The aim of this study was to examine the function of microcirculation throughout aging in @entity0 . Microcirculation was challenged by inhalation of 5% and 10% @entity5 or by forepaw stimulation in 6-week, 8-month, and 12-month-old FVB/ @entity0 . The resulting dilation of pial vessels and increase in CBF was measured by intravital fluorescence microscopy and laser Doppler fluxmetry, respectively. Neurovascular coupling and astrocytic endfoot @entity2 were measured in acute brain slices from 18-month-old @entity0 . We did not reveal any changes in CBF after @entity5 reactivity up to an age of 12 months. However, direct visualization of pial vessels by in vivo microscopy showed a significant, age-dependent loss of @entity5 reactivity starting at 8 months of age. At the same age neurovascular coupling was also significantly affected. These results suggest that aging does not affect cerebral vessel function simultaneously, but starts in pial microvessels months before global changes in CBF are detectable.Journal of Cerebral Blood Flow _ Metabolism advance online publication, 10 June 2015; doi:10.1038/jcbfm.2015.107.

title: Dysfunction of XXXX cerebral arteries during early aging.

answer: @entity0