abstract: GOAL: We aimed to summarize pooled rebleeding rates of angioectasia after therapeutic endoscopy, and compare these to historical control (no intervention) rates. BACKGROUND: Obscure @entity2 continues to be challenging to diagnose and treat; in America, @entity1 are the most common cause. Technology advances led to higher diagnostic yield for these lesions; however, therapeutic impact of endoscopy remains unclear. STUDY: A PubMed search (June 1, 2006 to September 19, 2013) with 2 independent reviews sought articles reporting rebleeding rates of symptomatic angioectasia without therapy (natural history) and after endoscopic treatment. This study list was added to studies in the 2007 American Gastroenterological Association systematic review. Data on number of @entity0 who underwent endoscopic therapy, type of therapy used, number of @entity0 who experienced rebleeding, and follow-up time were extracted. Rebleeding data were pooled and weighted averages were reported with 95% confidence intervals (CI). RESULTS: Twenty-four articles (n=490 @entity0 ) with data on endoscopic therapy for angioectasia and 6 natural history cohorts (n=130) receiving no therapy for angioectasia were eligible. Of the endoscopic therapy @entity0 , 121 at push enteroscopy and 427 at balloon-assisted enteroscopy; 209/490 (42.7%; 95% CI, 38%-47%) rebled. Of the control (no therapy) @entity0 , 64/130 (49.2%; 95% CI, 40%-58%) rebled. Number needed to treat is estimated at 15 to 16. CONCLUSIONS: Rebleeding rate after endoscopic therapy for symptomatic @entity1 may be comparable to that expected without therapy. Endoscopic therapy may be ineffective; if effective, the needed to treat is estimated to be high. Controlled studies, with intervention-stratified and etiology-stratified outcomes are needed.

title: Is Endoscopic Therapy Effective for Angioectasia in Obscure XXXX ?: A Systematic Review of the Literature.

answer: @entity2


abstract: OBJECTIVES: Healing is an event that is fundamental to the success of total knee arthroplasty. The aims of the present study were to compare the rates of complications related to wound healing between two groups of volunteers submitted to total knee arthroplasty and to evaluate the effects of postoperative @entity1 supplementation by means of a nasal catheter. METHOD: A total of 109 @entity0 who underwent total knee arthroplasty were randomized into two groups, namely, groups that did and did not receive postoperative @entity1 supplementation via a nasal catheter. The surgical wound was monitored every day during the hospital stay and on the 7th, 14th, 21st, 30th and 42nd postoperative days. Characteristics related to healing were observed, including @entity4 , dehiscence, @entity2 , phlyctenules and deep and superficial infection. RESULTS: There were no cases of @entity3 . @entity4 was statistically correlated with the total number of complications in the groups, with @entity1 demonstrated to be a protective factor against @entity4 . Approximately 30% of the @entity0 who exhibited @entity4 had other complications, independent of @entity1 supplementation. CONCLUSION: @entity1 supplementation following total knee arthroplasty was shown to be effective in diminishing @entity4 around the operative wound. The development of @entity4 was a precursor to other complications, irrespective of whether @entity1 supplementation was used.

title: Effect of postoperative use of nasal XXXX catheter supplementation in wound healing following total knee arthroplasty.

answer: @entity1


abstract: UNASSIGNED: Background and aims As @entity4 is the goal of treatment in @entity1 , defining a faecal (f-) calprotectin cut-off level for @entity4 is crucial. Previous studies have presented different cut-off levels. The aim of this study was to investigate the ability of two f-calprotectin assays to differentiate @entity4 from @entity3 in @entity2 . Methods Sixty-two @entity0 with @entity2 underwent colonoscopy for classification of @entity3 (Mayo endoscopic subscore). The @entity0 also submitted a faecal sample for f-calprotectin analysis using two different ELISA assays, Calpro ELISA and B  hlmann ELISA. Results The two assays correlated significantly, with a Spearman rank correlation coefficient of 0.86. Both assays showed significantly different f-calprotectin levels in @entity0 with a Mayo endoscopic subscore of 0 ( @entity4 ) and 1-3 (inflamed mucosa) (p < 0.001). Using ROC curve analyses we selected the best cut-off levels for both assays with responding sensitivity and specificity (presented with 95% confidence intervals); Calpro ELISA cut-off 61  g/g, sensitivity 84.1 % (75.0-93.2%), specificity 83.3 % (74.0-92.6%), and B  hlmann ELISA cut-off 96  g/g, sensitivity 90.9 % (83.7-98.1%), specificity 83.3 % (74.0-92.6%). Defining @entity4 as a Mayo endoscopic subscore  <= 1, cut-off levels increased; Calpro ELISA cut-off 110  g/g, sensitivity 80.0 % (70-90%), specificity 66.6 % (54.9-78.3%), and B  hlmann ELISA cut-off 259   g/g, sensitivity 83.3 % (74-92.6%), specificity 71.9 % (60.7-83.1%). Conclusions The study demonstrates the need for assay specific cut-off levels in clinical practice, as the f-calprotectin cut-off level for endoscopic disease activity differed in these two assays.

title: Prediction of endoscopic disease activity in XXXX by two different assays for faecal calprotectin.

answer: @entity2


abstract: The potencies of four @entity1 antagonists ( @entity3 , @entity7 , @entity4 and @entity6 ) at inhibiting uterine contractions in vivo have been assessed in the conscious ovariectomized, post-partum @entity0 . Their selectivities for this action, relative to their effects on blood pressure and heart rate, have been compared with @entity5 . All compounds produced a dose-dependent inhibition of intra-uterine pressure cycles. The rank order of potency was @entity5 greater than @entity3 greater than @entity6 = @entity7 greater than @entity4 . All compounds produced a dose-dependent fall of mean blood pressure. The rank order of potency was @entity5 greater than @entity3 greater than @entity7 greater than @entity4 greater than @entity6 . @entity5 and @entity3 produced a @entity2 , which was very marked with @entity5 . @entity7 , @entity4 and @entity6 induced a moderate @entity2 at low doses but temporary cessation of heart beat occurred at high doses. @entity3 and @entity6 , like @entity5 , exhibited some selectivity for inhibition of uterine contractions relative to their cardiovascular actions. @entity7 and @entity4 showed no selectivity for the uterus.

title: The potencies and selectivities of four XXXX antagonists as inhibitors of uterine contractions in the @entity0 in vivo.

answer: @entity1


abstract: The potencies of four @entity1 antagonists ( @entity3 , @entity7 , @entity4 and @entity6 ) at inhibiting uterine contractions in vivo have been assessed in the conscious ovariectomized, post-partum @entity0 . Their selectivities for this action, relative to their effects on blood pressure and heart rate, have been compared with @entity5 . All compounds produced a dose-dependent inhibition of intra-uterine pressure cycles. The rank order of potency was @entity5 greater than @entity3 greater than @entity6 = @entity7 greater than @entity4 . All compounds produced a dose-dependent fall of mean blood pressure. The rank order of potency was @entity5 greater than @entity3 greater than @entity7 greater than @entity4 greater than @entity6 . @entity5 and @entity3 produced a @entity2 , which was very marked with @entity5 . @entity7 , @entity4 and @entity6 induced a moderate @entity2 at low doses but temporary cessation of heart beat occurred at high doses. @entity3 and @entity6 , like @entity5 , exhibited some selectivity for inhibition of uterine contractions relative to their cardiovascular actions. @entity7 and @entity4 showed no selectivity for the uterus.

title: The potencies and selectivities of four @entity1 antagonists as inhibitors of uterine contractions in the XXXX in vivo.

answer: @entity0


abstract: The cardiovascular effects of @entity7 and @entity2 were compared in the anaesthetized and conscious @entity0 by the use of intravenous infusions over the dose range 3 X 10(-9) - 10(-7)mol kg-1 min-1. In the anaesthetized @entity0 , @entity7 produced a dose-related @entity1 due to @entity5 and a small rise in heart rate and contractility. By contrast, @entity2 did not significantly reduce blood pressure but produced a larger dose-related increase in contractility. At the highest infusion rate (10(-7)mol kg-1 min-1) blood pressure and heart rate were increased by @entity2 . @entity7 dilated the renal and mesenteric vascular beds with a potency similar to that of @entity2 . Femoral vascular responses produced by both agents were inconsistent but the highest infusion rate of @entity2 did produce vasoconstriction. With the aid of selective receptor antagonists ( @entity4 , @entity3 and @entity6 ) the vasodepressor activity of @entity7 was shown to be mediated by stimulation of DA2-, beta- and DA1-receptors. The cardiac stimulation and renal vasodilatation produced by both compounds were due to stimulation of beta-adrenoceptors and DA1-receptors respectively. In the conscious @entity0 , intravenous infusion of @entity7 caused a dose-related @entity1 , renal vasodilatation and an increase in cardiac contractility and heart rate. @entity2 also increased cardiac contractility, and renal blood flow due to renal vasodilatation but without affecting heart rate. At the highest infusion rate, blood pressure was increased. @entity7 and @entity2 produced a similar incidence of panting and repetitive licking at 3 X 10(-8)mol kg-1 min-1 and emesis at 10(-7)mol kg-1 min-1, due to stimulation of @entity2 receptors in the chemoreceptor trigger zone. @entity7 produces a different cardiovascular profile from @entity2 in the anaesthetized and conscious @entity0 . Both compounds reduce renal vascular resistance, but in contrast to @entity2 , @entity7 reduces afterload and produces only mild inotropic stimulation. These differences reflect contrasting activity at adrenoceptors.

title: The effects of XXXX on the cardiovascular system of the @entity0 .

answer: @entity7


abstract: The cardiovascular effects of @entity7 and @entity2 were compared in the anaesthetized and conscious @entity0 by the use of intravenous infusions over the dose range 3 X 10(-9) - 10(-7)mol kg-1 min-1. In the anaesthetized @entity0 , @entity7 produced a dose-related @entity1 due to @entity5 and a small rise in heart rate and contractility. By contrast, @entity2 did not significantly reduce blood pressure but produced a larger dose-related increase in contractility. At the highest infusion rate (10(-7)mol kg-1 min-1) blood pressure and heart rate were increased by @entity2 . @entity7 dilated the renal and mesenteric vascular beds with a potency similar to that of @entity2 . Femoral vascular responses produced by both agents were inconsistent but the highest infusion rate of @entity2 did produce vasoconstriction. With the aid of selective receptor antagonists ( @entity4 , @entity3 and @entity6 ) the vasodepressor activity of @entity7 was shown to be mediated by stimulation of DA2-, beta- and DA1-receptors. The cardiac stimulation and renal vasodilatation produced by both compounds were due to stimulation of beta-adrenoceptors and DA1-receptors respectively. In the conscious @entity0 , intravenous infusion of @entity7 caused a dose-related @entity1 , renal vasodilatation and an increase in cardiac contractility and heart rate. @entity2 also increased cardiac contractility, and renal blood flow due to renal vasodilatation but without affecting heart rate. At the highest infusion rate, blood pressure was increased. @entity7 and @entity2 produced a similar incidence of panting and repetitive licking at 3 X 10(-8)mol kg-1 min-1 and emesis at 10(-7)mol kg-1 min-1, due to stimulation of @entity2 receptors in the chemoreceptor trigger zone. @entity7 produces a different cardiovascular profile from @entity2 in the anaesthetized and conscious @entity0 . Both compounds reduce renal vascular resistance, but in contrast to @entity2 , @entity7 reduces afterload and produces only mild inotropic stimulation. These differences reflect contrasting activity at adrenoceptors.

title: The effects of @entity7 on the cardiovascular system of the XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity5 ( @entity5 ) is a benign intraventricular @entity1 , usually located near the foramen of Monro. It is almost always associated with @entity4 ( @entity4 ). SGCTs may obstruct cerebrospinal fluid (CSF) pathways. Rarely, they may secrete a protein-rich exudate, causing communicating @entity2 . Surgery is indicated for symptomatic lesions or growing asymptomatic lesions. The operative approach to @entity5 has shifted from simple shunt placement to a more aggressive approach, leading to early attempts at gross total resection. Recently, the @entity6 inhibitor @entity3 has been approved for treating @entity5 . In this article, we present two cases of recurrent shunt malfunctions in adult @entity4 @entity0 with protein-secreting SGCTs. We describe the complexity of treating such @entity0 with an emphasis on the role @entity6 inhibitors may have in their management. We also review the literature on surgical management of @entity5 -related @entity2 .

title: Persistent communicating @entity2 in adult XXXX @entity0 : a possible therapeutic role for @entity3 .

answer: @entity4


abstract: UNASSIGNED: @entity5 ( @entity5 ) is a benign intraventricular @entity1 , usually located near the foramen of Monro. It is almost always associated with @entity4 ( @entity4 ). SGCTs may obstruct cerebrospinal fluid (CSF) pathways. Rarely, they may secrete a protein-rich exudate, causing communicating @entity2 . Surgery is indicated for symptomatic lesions or growing asymptomatic lesions. The operative approach to @entity5 has shifted from simple shunt placement to a more aggressive approach, leading to early attempts at gross total resection. Recently, the @entity6 inhibitor @entity3 has been approved for treating @entity5 . In this article, we present two cases of recurrent shunt malfunctions in adult @entity4 @entity0 with protein-secreting SGCTs. We describe the complexity of treating such @entity0 with an emphasis on the role @entity6 inhibitors may have in their management. We also review the literature on surgical management of @entity5 -related @entity2 .

title: Persistent communicating @entity2 in adult @entity4 @entity0 : a possible therapeutic role for XXXX .

answer: @entity3


abstract: UNASSIGNED: @entity5 ( @entity5 ) is a benign intraventricular @entity1 , usually located near the foramen of Monro. It is almost always associated with @entity4 ( @entity4 ). SGCTs may obstruct cerebrospinal fluid (CSF) pathways. Rarely, they may secrete a protein-rich exudate, causing communicating @entity2 . Surgery is indicated for symptomatic lesions or growing asymptomatic lesions. The operative approach to @entity5 has shifted from simple shunt placement to a more aggressive approach, leading to early attempts at gross total resection. Recently, the @entity6 inhibitor @entity3 has been approved for treating @entity5 . In this article, we present two cases of recurrent shunt malfunctions in adult @entity4 @entity0 with protein-secreting SGCTs. We describe the complexity of treating such @entity0 with an emphasis on the role @entity6 inhibitors may have in their management. We also review the literature on surgical management of @entity5 -related @entity2 .

title: Persistent communicating XXXX in adult @entity4 @entity0 : a possible therapeutic role for @entity3 .

answer: @entity2


abstract: UNASSIGNED: @entity5 ( @entity5 ) is a benign intraventricular @entity1 , usually located near the foramen of Monro. It is almost always associated with @entity4 ( @entity4 ). SGCTs may obstruct cerebrospinal fluid (CSF) pathways. Rarely, they may secrete a protein-rich exudate, causing communicating @entity2 . Surgery is indicated for symptomatic lesions or growing asymptomatic lesions. The operative approach to @entity5 has shifted from simple shunt placement to a more aggressive approach, leading to early attempts at gross total resection. Recently, the @entity6 inhibitor @entity3 has been approved for treating @entity5 . In this article, we present two cases of recurrent shunt malfunctions in adult @entity4 @entity0 with protein-secreting SGCTs. We describe the complexity of treating such @entity0 with an emphasis on the role @entity6 inhibitors may have in their management. We also review the literature on surgical management of @entity5 -related @entity2 .

title: Persistent communicating @entity2 in adult @entity4 XXXX : a possible therapeutic role for @entity3 .

answer: @entity0


abstract: UNASSIGNED: The use of saline water in urban areas for non-potable purposes to cope with fresh water scarcity, intrusion of saline water, and disposal of industrial saline wastewater into the sewerage lead to elevated salinity levels in wastewaters. Consequently, saline wastewater is generated, which needs to be treated before its discharge into surface water bodies. The objective of this research was to study the effects of salinity on the aerobic metabolism of @entity1 -accumulating organisms (PAO), which belong to the microbial populations responsible for enhanced biological @entity2 removal (EBPR) in activated sludge systems. In this study, the short-term impact (hours) of salinity (as @entity0 ) was assessed on the aerobic metabolism of a PAO culture, enriched in a sequencing batch reactor (SBR). All aerobic PAO metabolic processes were drastically affected by elevated salinity concentrations. The aerobic maintenance energy requirement increased, when the salinity concentration rose up to a threshold concentration of 2  % salinity (on a W/V basis as @entity0 ), while above this concentration, the maintenance energy requirements seemed to decrease. All initial rates were affected by salinity, with the @entity3 - and PO4-uptake rates being the most sensitive. A salinity increase from 0 to 0.18  % caused a 25, 46, and 63  % inhibition of the O2, PO4, and @entity3 -uptake rates. The stoichiometric ratios of the aerobic conversions confirmed that growth was the process with the highest inhibition, followed by poly-P and glycogen formation. The study indicates that shock loads of 0.18  % salt, which corresponds to the use or intrusion of about 5  % seawater may severely affect the EBPR process already in wastewater treatment plants not exposed regularly to high salinity concentrations.

title: Impact of salinity on the aerobic metabolism of XXXX -accumulating organisms.

answer: @entity1


abstract: UNASSIGNED: To facilitate assimilation of glutamine, different Na-dependent glutamine absorptive pathways are present in the @entity1 small intestine, specifically B0AT1 in villus and @entity2 in crypt cell brush border membrane. Further, both are uniquely regulated in the chronically inflamed intestine. B0AT1 is inhibited secondary to reduced number of brush border membrane (BBM) co-transporters while @entity2 is stimulated secondary to an increased affinity for glutamine. These unique changes are reversible by treatment with a broad spectrum immune modulator such as glucocorticoids. However, whether inducible nitric oxide (iNO), known to be elevated in the mucosa of the chronically inflamed intestine, may be responsible for these co-transporter alterations is not known. In the present study, treatment of chronically inflamed @entity1 with L-NIL, a selective inhibitor of iNO synthase, reversed the inhibition of B0AT1 in villus and the stimulation of @entity2 in crypt cells. At the level of the co-transporter in the brush border membrane, inhibition of iNO production reversed the inhibition of villus B0AT1 by restoring the co-transporter numbers while the stimulation of crypt @entity2 was reversed back to normal by restoring its affinity for glutamine. Western blot analyses of BBM proteins also confirmed the kinetic studies. Thus, L-NIL treatment restores the uniquely altered Na-glutamine co-transporters in the enterocytes of chronically inflamed intestine. All these data indicate that iNO functions as an upstream immune modulator directly regulating glutamine assimilation during chronic @entity0 .

title: Inducible nitric oxide regulates intestinal glutamine assimilation during chronic XXXX .

answer: @entity0


abstract: OBJECTIVE: This study describes the presentation of first @entity6 and compares outcomes of first @entity3 with other @entity6 with attention to otologic findings. STUDY DESIGN: Case series with chart review. SETTING: Pediatric tertiary care facility. METHODS: Surgical databases were queried to identify @entity0 with @entity6 . Descriptive analysis defined sample characteristics. Risk estimates were calculated using Fisher's exact test. RESULTS: Queries identified 126 subjects: 27 (21.4%) had first @entity6 , 80 (63.4%) had second, and 19 (15.1%) had third or fourth. @entity0 with first anomalies often presented with otologic complications, including @entity4 (22.2%), @entity2 media (25.9%), and @entity5 (14.8%). Of 80 @entity0 with second @entity6 , only 3 (3.8%) had @entity2 . Compared with @entity0 with second anomalies, @entity0 with first anomalies had a greater risk of requiring primary incision and drainage: 16 (59.3%) vs 2 (2.5%) (relative risk [RR], 3.5; 95% confidence interval [CI], 2.4-5; P < .0001). They were more likely to have persistent disease after primary excision: 7 (25.9%) vs 2 (2.5%) (RR, 3; 95% CI, 1.9-5; P = .0025). They were more likely to undergo additional surgery: 8 (29.6%) vs 3 (11.1%) (RR, 2.9; 95% CI, 1.8-4.7; P = .0025). Of 7 persistent first anomalies, 6 (85.7%) were medial to the facial nerve, and 4 (57.1%) required ear-specific surgery for management. CONCLUSIONS: @entity0 with first @entity6 often present with otologic complaints. They are at increased risk of persistent disease, @entity1 lie medial to the facial nerve. They may require ear-specific surgery such as tympanoplasty.

title: First XXXX : Otologic Manifestations and Treatment Outcomes.

answer: @entity6


abstract: UNASSIGNED: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve @entity2 and decrease @entity1 . Several clinical studies have reported that NSAIDs inhibit @entity9 ( @entity9 ) enzymes. Therefore, we evaluated the inhibitory potential of 15 NSAIDs on the activities of six @entity9 isoforms (i.e., @entity10 , 1A3, 1A4, 1A6, 1A9, and 2B7) in @entity0 liver microsomes (HLMs). Among the 15 NSAIDs tested here, @entity11 and @entity5 inhibited all UGTs tested in this study. @entity8 and @entity12 inhibited @entity18 activity (IC50    =   73.8    M and 0.38    M, respectively) and @entity4 selectively inhibited @entity16 activity (IC50    =   53.1    M), whereas it did not inhibit the other UGTs tested (IC50    >   200    M). Diflunisal inhibited the @entity10 (IC50    =   33.0    M) and @entity18 (IC50    =   19.4    M). @entity3 , @entity17 , @entity7 , @entity13 , @entity14 , @entity15 , @entity6 , and sulindac showed negligible inhibitory effects on the six UGTs (IC50    >   100    M). These results suggest that some NSAIDs have the potential to inhibit UGTs in vitro. This article is protected by copyright. All rights reserved.

title: Screening of non-steroidal anti-inflammatory drugs for inhibitory effects on the activities of six UDP-glucuronosyltransferases ( XXXX , 1A3, 1A4, 1A6, 1A9, and 2B7) using LC-MS/MS.

answer: @entity10


abstract: From a study of 69 @entity0 with @entity4 using digitised vectorcardiograms, it is suggested that the following features are evidence of a ventricular origin. 1. Anterior QRS predominantly in the left anterior quadrant. 2. Slow initial tangential QRS velocity greater than or equal to 20 ms in the presence of an anterior QRS monophasic loop. 3. QRS totally in the right posterior quadrant. 4. In the presence of a QRS in the left posterior quadrant slow anterior QRS initial forces lasting greater than or equal 20 ms in the horizontal plane. The following features are suggestive of a ventricular origin. 1. Slow initial tangential QRS velocity greater than or equal to 20 ms in the presence of an anterior QRS loop resembling @entity2 ( @entity2 ). 2. Anterior monophasic QRS loop with counterclockwise rotation. 3. Slow initial QRS forces posteriorly (TV of first 40 ms less than 10 mV . s-1) in the presence of a QRS loop in the left posterior quadrant. 4. A vertical right QRS @entity5 greater than or equal to +60 degrees in the presence of a @entity2 ( @entity2 ) loop in the horizontal plane and any @entity5 greater than or equal to +90 degrees less than or equal to -160 degrees. The importance of three simultaneous perpendicular leads for recording or @entity3 is stressed. In addition vectorcardiograms have clearly separated multifocal @entity4 from multiformity, fusion beats with and without aberration, and bundle branch @entity4 . It is suggested that further study of the QRS waveform at the initiation and termination of @entity4 will elucidate the mechanisms and types of @entity1 .

title: Vectorcardiographic analysis of XXXX .

answer: @entity4


abstract: @entity3 -induced @entity2 ( @entity2 ) was evaluated at 20 min and 1, 3, 4.5, 5.5, 7, and 9 h postexposure (acute dose, @entity3 , 3.3 mmol/kg) in concanavalin A (Con A)- and lipopolysaccharide (LPS)-stimulated @entity0 peripheral blood lymphocytes (PBL). In both Con A- and LPS-stimulated PBL, @entity2 responses peaked between 4.5 and 5.5 h postinjection, a time which corresponds to complete biotransformation of @entity3 . Peak induced SCEs for Con A- and LPS-stimulated PBL were 6.43 and 7.44, respectively. @entity2 responses were also evaluated in Con A- and LPS-stimulated PBL at 3 and 24 h following the last of a series of two, four, or six i.p. injections of @entity3 (3.3 mmol/kg) given every other day. Dose-related increases (presumably reflecting the accumulation of unrepaired @entity2 -inducing damage) in SCEs were observed at both times following two and four injections of @entity3 . However, following six injections a decrease in @entity2 response and increased @entity1 were observed. Persistence of @entity2 -inducing DNA lesions was observed in blood, spleen, and parathymic node lymphocytes following the last of a series of 12 i.p. injections (three times weekly) of @entity3 (2.2 mmol/kg). With the exception of LPS-stimulated blood lymphocytes, exposed blood and spleen Con A- and LPS-stimulated lymphocyte populations contained a significantly higher number of high-frequency cells than did their respective controls at 16 weeks postexposure. The gradual return of @entity2 levels to base-line values appears to be primarily a consequence of slow population turnover. Parathymic node lymphocytes exhibited elevated @entity2 responses (2 times base-line levels) for up to 4 weeks postexposure.

title: Long-term persistence of XXXX -induced sister chromatid exchanges in @entity0 lymphocytes.

answer: @entity3


abstract: @entity3 -induced @entity2 ( @entity2 ) was evaluated at 20 min and 1, 3, 4.5, 5.5, 7, and 9 h postexposure (acute dose, @entity3 , 3.3 mmol/kg) in concanavalin A (Con A)- and lipopolysaccharide (LPS)-stimulated @entity0 peripheral blood lymphocytes (PBL). In both Con A- and LPS-stimulated PBL, @entity2 responses peaked between 4.5 and 5.5 h postinjection, a time which corresponds to complete biotransformation of @entity3 . Peak induced SCEs for Con A- and LPS-stimulated PBL were 6.43 and 7.44, respectively. @entity2 responses were also evaluated in Con A- and LPS-stimulated PBL at 3 and 24 h following the last of a series of two, four, or six i.p. injections of @entity3 (3.3 mmol/kg) given every other day. Dose-related increases (presumably reflecting the accumulation of unrepaired @entity2 -inducing damage) in SCEs were observed at both times following two and four injections of @entity3 . However, following six injections a decrease in @entity2 response and increased @entity1 were observed. Persistence of @entity2 -inducing DNA lesions was observed in blood, spleen, and parathymic node lymphocytes following the last of a series of 12 i.p. injections (three times weekly) of @entity3 (2.2 mmol/kg). With the exception of LPS-stimulated blood lymphocytes, exposed blood and spleen Con A- and LPS-stimulated lymphocyte populations contained a significantly higher number of high-frequency cells than did their respective controls at 16 weeks postexposure. The gradual return of @entity2 levels to base-line values appears to be primarily a consequence of slow population turnover. Parathymic node lymphocytes exhibited elevated @entity2 responses (2 times base-line levels) for up to 4 weeks postexposure.

title: Long-term persistence of @entity3 -induced sister chromatid exchanges in XXXX lymphocytes.

answer: @entity0


abstract: The @entity3 composition and antioxidant properties of three Lysimachia species (L. nummularia L., L. vulgaris L. and @entity8 L.) and their column chromatographic fractions were investigated. The antioxidant activity of herb extracts and 54 different column chromatographic fractions was evaluated using in vitro DPPH and @entity6 decolorization tests. The total @entity3 content was determined by spectrophotometric methods. The phenolic compounds of extracts of different Lysimachia species and their bioactive fractions were characterized by online chromatographic methods. For identification of the compounds, UV spectral data, accurate molecular mass and formula, as well as @entity0 and fragmentation patterns given by LC-DAD-ESI/ @entity0 / @entity0 and LC-ESI- TOF analyses were used. Quantification of the compounds was performed by LC-DAD using an external standard method. In the extracts, @entity5 derivatives, @entity4 , free flavonoid aglycones, and 11 various flavonoid glycosides were identified. @entity2 composition of Lysimachia extracts showed significant differences. @entity8 extracts had the strongest DPPH and @entity6 + radical scavenger activity (IC50=43.3  g/mL and 21.3  g/mL), due to their high @entity7 and @entity1 - @entity9 content. Correlation between @entity3 content and radical scavenging activity of each column chromatographic fractions is also included.

title: XXXX composition and antioxidant capacity of three Lysimachia species.

answer: @entity3


abstract: OBJECTIVE: To investigate the clinical relationship between @entity4 and @entity1 with chronic rhinosinusitis with or without @entity3 . METHOD: Two hundred @entity0 were divided into A and B two groups. Group A of 110 @entity0 was diagnosed @entity4 . Group B of 90 @entity0 was diagnosed @entity2 with or without @entity3 . Serums sIgE was detected with EUROIMMUN, and observe the recurrence rate of @entity2 with or without @entity3 @entity0 who accept operation treatment and observe the incidence of @entity4 superinduced @entity2 with or without @entity3 . RESULT: The total positive rate of group A sIgE was 89.09%. The total positive rate of group B sIgE was 74.44%. The postoperative recurrence rate of sIgE positive group was 58.21% and the postoperative recurrence rate of sIgE negative group was 8.70% in the group B. In the group A, the positive rate of serums sIgE in @entity4 with @entity2 with or without @entity3 (37.27%) was 97.56%, while the positive rate of serums sIgE in @entity4 without @entity2 (62.73%) was 79.71%, there is a significant difference in @entity4 with or without @entity2 (  2 = 6.96, P < 0.01). CONCLUSION: There is a certain correlation between @entity4 and @entity1 with @entity2 with or without @entity3 . Therefore, through avoiding allergen exposure, the treatment of @entity4 can effectively control recurrence rate of @entity2 and @entity3 .

title: [The clinical relationship between @entity1 with or without XXXX ].

answer: @entity3


abstract: OBJECTIVE: To investigate the clinical relationship between @entity4 and @entity1 with chronic rhinosinusitis with or without @entity3 . METHOD: Two hundred @entity0 were divided into A and B two groups. Group A of 110 @entity0 was diagnosed @entity4 . Group B of 90 @entity0 was diagnosed @entity2 with or without @entity3 . Serums sIgE was detected with EUROIMMUN, and observe the recurrence rate of @entity2 with or without @entity3 @entity0 who accept operation treatment and observe the incidence of @entity4 superinduced @entity2 with or without @entity3 . RESULT: The total positive rate of group A sIgE was 89.09%. The total positive rate of group B sIgE was 74.44%. The postoperative recurrence rate of sIgE positive group was 58.21% and the postoperative recurrence rate of sIgE negative group was 8.70% in the group B. In the group A, the positive rate of serums sIgE in @entity4 with @entity2 with or without @entity3 (37.27%) was 97.56%, while the positive rate of serums sIgE in @entity4 without @entity2 (62.73%) was 79.71%, there is a significant difference in @entity4 with or without @entity2 (  2 = 6.96, P < 0.01). CONCLUSION: There is a certain correlation between @entity4 and @entity1 with @entity2 with or without @entity3 . Therefore, through avoiding allergen exposure, the treatment of @entity4 can effectively control recurrence rate of @entity2 and @entity3 .

title: [The clinical relationship between XXXX with or without @entity3 ].

answer: @entity1


abstract: The purpose of this study was to determine the contribution of muscle afferents and central command in regulating sympathetic nerve activity during static exercise in @entity0 . In 20 healthy subjects, we recorded heart rate, arterial pressure, and efferent sympathetic nerve activity in the leg during arm exercise. Microelectrodes were inserted percutaneously into a fascicle of the peroneal nerve to measure sympathetic discharge to muscle. Measurements were obtained in nine subjects during sustained handgrip (30% maximal @entity2 ) followed by relaxation or by arrested circulation of the forearm. Heart rate and arterial pressure increased during the first and second minutes of handgrip. Muscle sympathetic nerve activity increased from 261 +/- 46 to 504 +/- 97 units (mean +/- SE; units = burst frequency X amplitude; P less than 0.05) during the second minute of handgrip. During @entity1 following handgrip, heart rate returned promptly to control, whereas arterial pressure and muscle sympathetic nerve activity (631 +/- 115 units) remained elevated. In contrast, muscle sympathetic nerve activity returned toward control during relaxation without arrested circulation. These data indicate that muscle sympathetic nerve activity is increased by stimulation of chemically sensitive muscle afferents. To determine the influence of central command on muscle sympathetic nerve activity, we compared responses during an involuntary and a @entity2 , each at 20% maximal @entity2 . Both maneuvers raised arterial pressure, but heart rate increased only during @entity2 . More importantly, muscle sympathetic nerve activity rose during involuntary contraction, but fell during voluntary effort.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in XXXX .

answer: @entity0


abstract: Thirty consecutive @entity0 with far-advanced @entity1 affecting the esophagus and gastroesophageal junction underwent palliative endoscopic neodymium-YAG laser therapy. No @entity0 were excluded from treatment, regardless of age, extent of disease, or performance status. Sessions were performed every other day and concluded when an endoscope could be easily passed beyond the previously obstructed area. Treatment was completed in 3.3 sessions (seven days). Luminal patency was achieved in 97%, but did not always equate with functional success. Seventy percent (21 @entity0 ) were able to ingest all necessary calories and leave hospital for home (functional success). Reasons for discrepancy between technical success and functional success included radiation-induced @entity5 , @entity4 , @entity2 load and debility, and treatment complications. Endoscopic laser therapy of far-advanced esophageal or gastroesophageal junction @entity3 was almost always technically feasible, with relatively low morbidity. While technical success could not always be equated with functional success, therapy was "completely" functionally successful in 70% of @entity0 with @entity6 . Poor performance status at accession correlated best with poor functional outcome.

title: Endoscopic laser therapy for XXXX affecting the esophagus and gastroesophageal junction. Analysis of technical and functional efficacy.

answer: @entity1


abstract: AIM: @entity1 ( @entity1 ) are used to manage acute @entity3 and facilitate brain relaxation after @entity2 ( @entity2 ). We conducted a retrospective study on the relationship between @entity5 drainage volume and requirement and timing (early vs. late) for ventriculoperitoneal shunt (VPS) placement after EVD removal. We also sought to examine what factors were associated with volume of @entity5 drainage. METHODS: We performed a retrospective analysis of @entity2 @entity0 who had an EVD placed between January 2008 and June 2012 at Massachusetts General Hospital. Clinical and laboratory variables were abstracted from the medical record. RESULTS: Of 97 @entity0 , 19 failed an EVD clamp trial and had an early VPS placed and 10 had their EVD removed but subsequently required late VPS placement. Average @entity5 drainage volume per day was highest in @entity0 who required early VPS (median of 201cc, interquartile range (IQR) 186---236) compared to those who did not require a VPS (median of 162cc, IQR 131---202) and those who required late VPS (median of 151cc, IQR 121---171) (p=0.002). There was a significant relationship between average @entity5 drainage volume per day and age (p=0.005) and sonographic @entity4 (p=0.006). After multivariate analysis, there was a significant relationship between VPS placement/timing and age (p=0.03) and average @entity5 output/day (p=<0.0001), and a trend towards significance with sonographic @entity4 (p=0.06). CONCLUSION: High @entity5 output is associated with early VPS placement. Prospective research on targeted @entity5 drainage volume is warranted.

title: A retrospective analysis of cerebrospinal fluid drainage volume in XXXX and the need for early or late ventriculoperitoneal shunt placement.

answer: @entity2


abstract: UNASSIGNED: The aim of this study was the evaluation of @entity9 inside the Albanian population, its clinical, cytological and genetic characteristics, the accompanying pathologies, and the efficacy of the treatment with the @entity8 . We performed a retrospective analysis of 59 @entity0 suffering from this syndrome (aging from 5 to 23 years old). The diagnosis of female @entity0 suffering from @entity9 is delayed, with a mean age at the moment of diagnosis of 13.74 years (5-23 years). The main reason for seeking medical advice was the @entity4 or a delayed puberty. Available data for 52 @entity0 showed that the most frequent accompanying pathologies were the following: @entity7 (59%), @entity5 (43%), renal pathologies (41%), @entity3 (4.3%) and @entity1 (3.3%). Follow-up for the growth rate was possible for 52 @entity0 out of the total of 59 @entity0 . Twenty-five of the female @entity0 suffering @entity9 and forming part of our study sample were treated with @entity8 for a period averaging 3 years and 4 months. A variety of reasons was identified as responsible for the missed treatment in 27 @entity0 . We saw an enhanced growth (in terms of body height) within the treated subgroup, when compared with the untreated subgroup (27 @entity0 ), especially during the first 3 years of the follow-up. No side effects of this treatment were reported. Both groups of @entity0 initiated as well a sexual hormone therapy ( @entity2 and @entity6 ) for inducing puberty at the age of 12 years. Further work is needed for an early diagnosis of this syndrome, the prompt treatment with @entity8 and the monitoring of accompanying disorders. This will ensure a better quality of life and an improvement of the longevity of @entity0 suffering from the @entity9 .

title: XXXX in Albania and the efficacy of its treatment with @entity8 .

answer: @entity9


abstract: UNASSIGNED: The aim of this study was the evaluation of @entity9 inside the Albanian population, its clinical, cytological and genetic characteristics, the accompanying pathologies, and the efficacy of the treatment with the @entity8 . We performed a retrospective analysis of 59 @entity0 suffering from this syndrome (aging from 5 to 23 years old). The diagnosis of female @entity0 suffering from @entity9 is delayed, with a mean age at the moment of diagnosis of 13.74 years (5-23 years). The main reason for seeking medical advice was the @entity4 or a delayed puberty. Available data for 52 @entity0 showed that the most frequent accompanying pathologies were the following: @entity7 (59%), @entity5 (43%), renal pathologies (41%), @entity3 (4.3%) and @entity1 (3.3%). Follow-up for the growth rate was possible for 52 @entity0 out of the total of 59 @entity0 . Twenty-five of the female @entity0 suffering @entity9 and forming part of our study sample were treated with @entity8 for a period averaging 3 years and 4 months. A variety of reasons was identified as responsible for the missed treatment in 27 @entity0 . We saw an enhanced growth (in terms of body height) within the treated subgroup, when compared with the untreated subgroup (27 @entity0 ), especially during the first 3 years of the follow-up. No side effects of this treatment were reported. Both groups of @entity0 initiated as well a sexual hormone therapy ( @entity2 and @entity6 ) for inducing puberty at the age of 12 years. Further work is needed for an early diagnosis of this syndrome, the prompt treatment with @entity8 and the monitoring of accompanying disorders. This will ensure a better quality of life and an improvement of the longevity of @entity0 suffering from the @entity9 .

title: @entity9 in Albania and the efficacy of its treatment with XXXX .

answer: @entity8


abstract: UNASSIGNED: Due to numerous industrial applications, lead has caused widespread pollution in the environment; it seems that the central nervous system (CNS) is the main target for lead in the @entity0 body. Oxidative stress and programmed cell death in the CNS have been assumed as two mechanisms related to @entity5 of lead. Cerium oxide (CeO2) and yttrium oxide (Y2O3) nanoparticles have recently shown antioxidant effects, particularly when used together, through scavenging the amount of reactive oxygen species (ROS) required for cell apoptosis. We looked into the neuroprotective effects of the combinations of these nanoparticles against acute lead-induced @entity5 in @entity1 hippocampus. We used five groups in this study: control, lead, CeO2 nanoparticles + lead, Y2O3 nanoparticles + lead, and CeO2 and Y2O3 nanoparticles + lead. Nanoparticles of CeO2 (1000  mg/kg) and Y2O3 (230  mg/kg) were administered intraperitoneally during 2  days prior to intraperitoneal injection of the lead (25  mg/kg for 3  days). At the end of the treatments, oxidative stress markers, antioxidant enzymes activity, and apoptosis indexes were investigated. The results demonstrated that pretreatments with CeO2 and/or Y2O3 nanoparticles recovered lead-caused oxidative stress markers (ROS, lipid peroxidation, and total thiol molecules) and apoptosis indexes ( @entity4 / @entity3 and @entity6 protein expression). Besides, these nanoparticles reduced the activities of lead-induced superoxide dismutase and @entity7 as well as the ADP/ATP ratio. Interestingly, the best recovery resulted from the compound of these nanoparticles. Based on these outcomes, it appears that this combination may potentially be beneficial for protection against lead-caused acute @entity2 in the brain through improving the oxidative stress-mediated programmed cell death pathway.

title: Cerium and Yttrium Oxide Nanoparticles Against Lead-Induced Oxidative Stress and Apoptosis in XXXX Hippocampus.

answer: @entity1


abstract: AIM: Telomerase is a ribonucleoprotein that maintains telomere length. Telomeres and telomerase are involved in cellular ageing and have been connected to some aging @entity2 , like @entity1 . Telomerase dysfunction could be the main underlying mechanism in this connection but this point is still unclear. The aim of this article is to investigate the possible influence of cellular ageing, measured by two telomerase polymorphisms, @entity7 --63G>A ( @entity9 ) and @entity6 --1327C>T ( @entity8 ), on the whole spectrum of acute @entity4 . METHODS: We studied 150 middle aged @entity0 admitted for an @entity5 . Cardiovascular risk factors prevalence was collected at admission. Severity variables analyzed were Killip class and number of vessels affected. Telomerase polymorphisms were studied by real time PCR in DNA samples extracted from peripheral blood leukocytes. Clinical follow up had been developed for more than 600 days and a prognostic combined event was defined. RESULTS: C allele of @entity6 polymorphism was more prevalent among @entity3 @entity0 (OR: 3.19; 95% CI: 1.37-7.42; p= 0.006). None of polymorphisms showed any prognostic value or relation to @entity4 severity. CONCLUSION: Telomerase dysfunction could be involved in @entity3 prevalence. This finding could support new screening strategies in high risk population. The two telomerase polymorphisms analyzed did not show any prognostic value or connection to @entity4 severity. However, further studies are required to determine the molecular mechanisms responsible for cellular ageing in @entity5 .

title: The role of the @entity7 -63g>a and @entity6 -1327c>t telomerase polymorphisms in the study of @entity0 with XXXX .

answer: @entity5


abstract: AIM: Telomerase is a ribonucleoprotein that maintains telomere length. Telomeres and telomerase are involved in cellular ageing and have been connected to some aging @entity2 , like @entity1 . Telomerase dysfunction could be the main underlying mechanism in this connection but this point is still unclear. The aim of this article is to investigate the possible influence of cellular ageing, measured by two telomerase polymorphisms, @entity7 --63G>A ( @entity9 ) and @entity6 --1327C>T ( @entity8 ), on the whole spectrum of acute @entity4 . METHODS: We studied 150 middle aged @entity0 admitted for an @entity5 . Cardiovascular risk factors prevalence was collected at admission. Severity variables analyzed were Killip class and number of vessels affected. Telomerase polymorphisms were studied by real time PCR in DNA samples extracted from peripheral blood leukocytes. Clinical follow up had been developed for more than 600 days and a prognostic combined event was defined. RESULTS: C allele of @entity6 polymorphism was more prevalent among @entity3 @entity0 (OR: 3.19; 95% CI: 1.37-7.42; p= 0.006). None of polymorphisms showed any prognostic value or relation to @entity4 severity. CONCLUSION: Telomerase dysfunction could be involved in @entity3 prevalence. This finding could support new screening strategies in high risk population. The two telomerase polymorphisms analyzed did not show any prognostic value or connection to @entity4 severity. However, further studies are required to determine the molecular mechanisms responsible for cellular ageing in @entity5 .

title: The role of the @entity7 -63g>a and XXXX -1327c>t telomerase polymorphisms in the study of @entity0 with @entity5 .

answer: @entity6


abstract: AIM: Telomerase is a ribonucleoprotein that maintains telomere length. Telomeres and telomerase are involved in cellular ageing and have been connected to some aging @entity2 , like @entity1 . Telomerase dysfunction could be the main underlying mechanism in this connection but this point is still unclear. The aim of this article is to investigate the possible influence of cellular ageing, measured by two telomerase polymorphisms, @entity7 --63G>A ( @entity9 ) and @entity6 --1327C>T ( @entity8 ), on the whole spectrum of acute @entity4 . METHODS: We studied 150 middle aged @entity0 admitted for an @entity5 . Cardiovascular risk factors prevalence was collected at admission. Severity variables analyzed were Killip class and number of vessels affected. Telomerase polymorphisms were studied by real time PCR in DNA samples extracted from peripheral blood leukocytes. Clinical follow up had been developed for more than 600 days and a prognostic combined event was defined. RESULTS: C allele of @entity6 polymorphism was more prevalent among @entity3 @entity0 (OR: 3.19; 95% CI: 1.37-7.42; p= 0.006). None of polymorphisms showed any prognostic value or relation to @entity4 severity. CONCLUSION: Telomerase dysfunction could be involved in @entity3 prevalence. This finding could support new screening strategies in high risk population. The two telomerase polymorphisms analyzed did not show any prognostic value or connection to @entity4 severity. However, further studies are required to determine the molecular mechanisms responsible for cellular ageing in @entity5 .

title: The role of the XXXX -63g>a and @entity6 -1327c>t telomerase polymorphisms in the study of @entity0 with @entity5 .

answer: @entity7


abstract: AIM: Telomerase is a ribonucleoprotein that maintains telomere length. Telomeres and telomerase are involved in cellular ageing and have been connected to some aging @entity2 , like @entity1 . Telomerase dysfunction could be the main underlying mechanism in this connection but this point is still unclear. The aim of this article is to investigate the possible influence of cellular ageing, measured by two telomerase polymorphisms, @entity7 --63G>A ( @entity9 ) and @entity6 --1327C>T ( @entity8 ), on the whole spectrum of acute @entity4 . METHODS: We studied 150 middle aged @entity0 admitted for an @entity5 . Cardiovascular risk factors prevalence was collected at admission. Severity variables analyzed were Killip class and number of vessels affected. Telomerase polymorphisms were studied by real time PCR in DNA samples extracted from peripheral blood leukocytes. Clinical follow up had been developed for more than 600 days and a prognostic combined event was defined. RESULTS: C allele of @entity6 polymorphism was more prevalent among @entity3 @entity0 (OR: 3.19; 95% CI: 1.37-7.42; p= 0.006). None of polymorphisms showed any prognostic value or relation to @entity4 severity. CONCLUSION: Telomerase dysfunction could be involved in @entity3 prevalence. This finding could support new screening strategies in high risk population. The two telomerase polymorphisms analyzed did not show any prognostic value or connection to @entity4 severity. However, further studies are required to determine the molecular mechanisms responsible for cellular ageing in @entity5 .

title: The role of the @entity7 -63g>a and @entity6 -1327c>t telomerase polymorphisms in the study of XXXX with @entity5 .

answer: @entity0


abstract: Histomorphometric changes in the trabecular structure of the principal compressive stress region in the femur in @entity0 with @entity2 and @entity1 of the femoral neck are described. Femoral heads were obtained from @entity0 who had surgery for the treatment of @entity3 or total hip replacement for advanced @entity2 . Blocks from the principal compressive region of a coronal slice were sampled systematically to prepare 10 microns sections for automated analysis. There was no significant difference in the mineral bone content of the osteoarthritic (OA) and @entity3 ( @entity3 ) cases or between males and females for each group. The regression of mineralized bone on age was significant for OA data, showing a decrease in mineralized bone volume with age, whereas there was no significant relationship for the @entity3 data. Surface density was significantly lower in the OA group than in the @entity3 group despite the fact there is no difference in the mineralized bone. The regression of surface density on age was not statistically significant in both groups, although regression of surface density on the mineralized bone was significant for both groups and demonstrated that OA cases generated less surface than @entity3 cases for the same amount of mineralized bone volume. The trabeculae in OA were significantly thicker than in @entity3 , and spacing in OA was significantly greater than in @entity3 . The regression of trabecular thickness and spacing on age was not significant for either OA or @entity3 . For OA, thickness and spacing showed a significant regression on the mineralized bone volume, positive and negative, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Histomorphometric changes in the trabecular structure of a selected stress region in the femur in @entity0 with XXXX and @entity1 of the femoral neck.

answer: @entity2


abstract: Histomorphometric changes in the trabecular structure of the principal compressive stress region in the femur in @entity0 with @entity2 and @entity1 of the femoral neck are described. Femoral heads were obtained from @entity0 who had surgery for the treatment of @entity3 or total hip replacement for advanced @entity2 . Blocks from the principal compressive region of a coronal slice were sampled systematically to prepare 10 microns sections for automated analysis. There was no significant difference in the mineral bone content of the osteoarthritic (OA) and @entity3 ( @entity3 ) cases or between males and females for each group. The regression of mineralized bone on age was significant for OA data, showing a decrease in mineralized bone volume with age, whereas there was no significant relationship for the @entity3 data. Surface density was significantly lower in the OA group than in the @entity3 group despite the fact there is no difference in the mineralized bone. The regression of surface density on age was not statistically significant in both groups, although regression of surface density on the mineralized bone was significant for both groups and demonstrated that OA cases generated less surface than @entity3 cases for the same amount of mineralized bone volume. The trabeculae in OA were significantly thicker than in @entity3 , and spacing in OA was significantly greater than in @entity3 . The regression of trabecular thickness and spacing on age was not significant for either OA or @entity3 . For OA, thickness and spacing showed a significant regression on the mineralized bone volume, positive and negative, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Histomorphometric changes in the trabecular structure of a selected stress region in the femur in @entity0 with @entity2 and XXXX of the femoral neck.

answer: @entity1


abstract: Histomorphometric changes in the trabecular structure of the principal compressive stress region in the femur in @entity0 with @entity2 and @entity1 of the femoral neck are described. Femoral heads were obtained from @entity0 who had surgery for the treatment of @entity3 or total hip replacement for advanced @entity2 . Blocks from the principal compressive region of a coronal slice were sampled systematically to prepare 10 microns sections for automated analysis. There was no significant difference in the mineral bone content of the osteoarthritic (OA) and @entity3 ( @entity3 ) cases or between males and females for each group. The regression of mineralized bone on age was significant for OA data, showing a decrease in mineralized bone volume with age, whereas there was no significant relationship for the @entity3 data. Surface density was significantly lower in the OA group than in the @entity3 group despite the fact there is no difference in the mineralized bone. The regression of surface density on age was not statistically significant in both groups, although regression of surface density on the mineralized bone was significant for both groups and demonstrated that OA cases generated less surface than @entity3 cases for the same amount of mineralized bone volume. The trabeculae in OA were significantly thicker than in @entity3 , and spacing in OA was significantly greater than in @entity3 . The regression of trabecular thickness and spacing on age was not significant for either OA or @entity3 . For OA, thickness and spacing showed a significant regression on the mineralized bone volume, positive and negative, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Histomorphometric changes in the trabecular structure of a selected stress region in the femur in XXXX with @entity2 and @entity1 of the femoral neck.

answer: @entity0


abstract: BACKGROUND AND OBJECTIVES: Although resection of @entity2 with en bloc nephrectomy confers the potential benefit of improved @entity1 control, little has been published about the long-term post-operative renal function of these @entity0 . METHODS: Retrospective review of 54 @entity0 undergoing nephrectomy for @entity2 was performed. Clinicopathologic and treatment characteristics, pre- and post-operative @entity5 ( @entity6 ) values, and estimated glomerular filtration rates (eGFR) were recorded. The primary outcome measure was progression of @entity4 ( @entity4 ) stage. RESULTS: Median preoperative eGFR was 85   ml/min. Post-nephrectomy, median nadir eGFR was 44   ml/min, rebounding to 62   ml/min at median follow-up of 50 months. Of 49 @entity0 with preoperative eGFR >= 60   ml/min ( @entity4 stage 1,2), 51% preserved eGFR >= 60 postoperatively, whereas 49% progressed to @entity4 stage 3 (eGFR 30-59). Independent risk factors for progression of @entity4 stage were age and preoperative eGFR. Eleven @entity0 died of recurrent disease, whereas no @entity0 died of @entity3 ( @entity3 ) or required dialysis. CONCLUSIONS: Although progression of @entity4 stage occurs in nearly one-half of @entity0 followed for more than 4 years after nephrectomy for @entity2 , no @entity0 progressed to @entity3 or had a limitation in systemic therapy options, even with progression to @entity4 stage 3. J. Surg. Oncol. 2015 111:98-102.    2015 Wiley Periodicals, Inc.

title: Post-operative renal function following nephrectomy as part of en bloc resection of XXXX ( @entity2 ).

answer: @entity2


abstract: BACKGROUND AND OBJECTIVES: Although resection of @entity2 with en bloc nephrectomy confers the potential benefit of improved @entity1 control, little has been published about the long-term post-operative renal function of these @entity0 . METHODS: Retrospective review of 54 @entity0 undergoing nephrectomy for @entity2 was performed. Clinicopathologic and treatment characteristics, pre- and post-operative @entity5 ( @entity6 ) values, and estimated glomerular filtration rates (eGFR) were recorded. The primary outcome measure was progression of @entity4 ( @entity4 ) stage. RESULTS: Median preoperative eGFR was 85   ml/min. Post-nephrectomy, median nadir eGFR was 44   ml/min, rebounding to 62   ml/min at median follow-up of 50 months. Of 49 @entity0 with preoperative eGFR >= 60   ml/min ( @entity4 stage 1,2), 51% preserved eGFR >= 60 postoperatively, whereas 49% progressed to @entity4 stage 3 (eGFR 30-59). Independent risk factors for progression of @entity4 stage were age and preoperative eGFR. Eleven @entity0 died of recurrent disease, whereas no @entity0 died of @entity3 ( @entity3 ) or required dialysis. CONCLUSIONS: Although progression of @entity4 stage occurs in nearly one-half of @entity0 followed for more than 4 years after nephrectomy for @entity2 , no @entity0 progressed to @entity3 or had a limitation in systemic therapy options, even with progression to @entity4 stage 3. J. Surg. Oncol. 2015 111:98-102.    2015 Wiley Periodicals, Inc.

title: Post-operative renal function following nephrectomy as part of en bloc resection of @entity2 ( XXXX ).

answer: @entity2


abstract: OBJECTIVES: This study aims to investigate demographic features, type and localization of foreign bodies, mean hospitalization duration, and peri- and @entity1 ratios of @entity0 with @entity4 . @entity0 AND METHODS: Seventy @entity0 (23 males, 47 females; mean age 32  14.5 months; range 3 months to 10 years) who were diagnosed with @entity4 in our clinic between January 2007 and August 2010, and performed rigid bronchoscopy under general anesthesia were included in this study. RESULTS: Main findings were cough, wheezing, and witnessed @entity3 . No foreign body was detected in 14 @entity0 (20%). Foreign bodies in 56 @entity0 (80%) were successfully removed. Foreign bodies were located in the left bronchial tree in 23 @entity0 (41%), right bronchial tree in 18 @entity0 (32%), @entity2 in four @entity0 (7%), bilateral bronchial tree in three @entity0 (5%), carina in two @entity0 (3%), subglottic region in two @entity0 (3%), pyriform sinus in two @entity0 (2%), laryngeal ventricle in one @entity0 (1.7%), and right vocal cord in one @entity0 (1.7%). Foreign bodies were hard-shelled nuts in 23 @entity0 (41%), beans in 14 @entity0 (25%), plastic materials in 11 @entity0 (19%), and other bodies in eight @entity0 (14%). CONCLUSION: Foreign body @entity3 is a risky condition particularly for @entity0 under the age of four. Bronchoscopy is still the most commonly used and reliable diagnosis and treatment method. Foreign body @entity3 should be kept in mind in @entity0 with persistent cough, wheezing, and unilateral pulmonary findings in radiologic imaging.

title: [Foreign body XXXX : an urgent airway condition].

answer: @entity3


abstract: Concerns remain over the ability to stent across of the lower esophageal sphincter (LES) for @entity4 and the effects of gastroesophageal (GE) reflux. Thus, the aim of this study was to demonstrate minimal quality-of-life (QOL) side effects in @entity0 undergoing esophageal stenting across the LES. An Institutional Review Board-approved prospective clinical trial evaluated the results of the Gastrointestinal Symptom questionnaire that includes a @entity3 ( @entity3 ) assessment ( @entity3 -HRQL) and a @entity5 assessment. Consecutive @entity0 were enrolled in this clinical trial, with 81 per cent male, 19 per cent female, median age of 62 years, with @entity4 as their diagnosis. The median @entity5 score was 3 (only liquids can be tolerated) prestent and was improved to a median score of 0 (ability to eat all foods) poststent (P = 0.01). The median @entity3 score was 0 (none) prestent and did not change with a median score of 0 (none) poststent (P = 0.2). All @entity3 -related questions were unchanged prestent and poststent in all categories, specifically: frequency of @entity3 , time of day of reflux, @entity2 behind breastbone, and @entity2 medications. There was also no difference in regurgitation frequency (median prestent 1 vs poststent 0, P = 0.08), texture (prestent 2 [semisolid] vs poststent 1 [liquid]). There was only a statistical change in the ability to belch (prestent 0 [no ability] to poststent 1 [ability]), P = 0.02) and the ability to vomit. Esophageal stenting across the GE junction for @entity5 relief in @entity1 does not adversely effect a @entity0 's QOL in regard to reflux-related symptoms.

title: Gastroesophageal Reflux Disease-related Symptom Assessment in Subjects with XXXX Receiving Esophageal Stents.

answer: @entity1


abstract: OBJECTIVE: The contribution contains a comparison of the history data of adolescent @entity0 hospitalized at the Department of @entity0 Psychiatry, @entity0  s Faculty Hospital in Bratislava with the diagnoses of @entity4 ( @entity4 ), @entity2 ( @entity2 ) and with @entity5 ( @entity5 ). BACKGROUND: @entity4 is rarely recorded and little documented by the age of 18. The etiology of this disorder is still relatively unclear. METHODS: The data collection was carried out from @entity0 hospitalized between January 1, 2001 and December 31, 2012. We recorded data from 20 @entity0 hospitalized with @entity4 , 50 @entity0 hospitalized with @entity2 , and 50 @entity0 hospitalized with @entity5 . We collected and compared the data on family history, perinatal complications, early psychomotor development, data on psychical problems before their hospitalization, and presence of unfavorable life situations in their childhood. CONCLUSION: The data of adolescents with @entity4 are more similar to the data of @entity0 with @entity2 than @entity0 with @entity5 in terms of the burden of family history, the frequency of complications during pregnancy and delivery, and the frequency of the subsequent early @entity6 . In terms of unfavorable life situations and @entity3 for which they were monitored in a @entity1 ward before their hospitalization with @entity4 , their data are more similar to those of @entity0 with @entity5 than with @entity2 (Tab. 3, Fig. 1, Ref. 21). KEYWORDS: adolescent, @entity5 , psychoactive drugs, substance-induced @entity4 , early onset @entity2 .

title: Comparison of history of adolescents with substance-induced @entity4 , early onset XXXX and @entity5 .

answer: @entity2


abstract: OBJECTIVE: The contribution contains a comparison of the history data of adolescent @entity0 hospitalized at the Department of @entity0 Psychiatry, @entity0  s Faculty Hospital in Bratislava with the diagnoses of @entity4 ( @entity4 ), @entity2 ( @entity2 ) and with @entity5 ( @entity5 ). BACKGROUND: @entity4 is rarely recorded and little documented by the age of 18. The etiology of this disorder is still relatively unclear. METHODS: The data collection was carried out from @entity0 hospitalized between January 1, 2001 and December 31, 2012. We recorded data from 20 @entity0 hospitalized with @entity4 , 50 @entity0 hospitalized with @entity2 , and 50 @entity0 hospitalized with @entity5 . We collected and compared the data on family history, perinatal complications, early psychomotor development, data on psychical problems before their hospitalization, and presence of unfavorable life situations in their childhood. CONCLUSION: The data of adolescents with @entity4 are more similar to the data of @entity0 with @entity2 than @entity0 with @entity5 in terms of the burden of family history, the frequency of complications during pregnancy and delivery, and the frequency of the subsequent early @entity6 . In terms of unfavorable life situations and @entity3 for which they were monitored in a @entity1 ward before their hospitalization with @entity4 , their data are more similar to those of @entity0 with @entity5 than with @entity2 (Tab. 3, Fig. 1, Ref. 21). KEYWORDS: adolescent, @entity5 , psychoactive drugs, substance-induced @entity4 , early onset @entity2 .

title: Comparison of history of adolescents with substance-induced XXXX , early onset @entity2 and @entity5 .

answer: @entity4


abstract: OBJECTIVE: The contribution contains a comparison of the history data of adolescent @entity0 hospitalized at the Department of @entity0 Psychiatry, @entity0  s Faculty Hospital in Bratislava with the diagnoses of @entity4 ( @entity4 ), @entity2 ( @entity2 ) and with @entity5 ( @entity5 ). BACKGROUND: @entity4 is rarely recorded and little documented by the age of 18. The etiology of this disorder is still relatively unclear. METHODS: The data collection was carried out from @entity0 hospitalized between January 1, 2001 and December 31, 2012. We recorded data from 20 @entity0 hospitalized with @entity4 , 50 @entity0 hospitalized with @entity2 , and 50 @entity0 hospitalized with @entity5 . We collected and compared the data on family history, perinatal complications, early psychomotor development, data on psychical problems before their hospitalization, and presence of unfavorable life situations in their childhood. CONCLUSION: The data of adolescents with @entity4 are more similar to the data of @entity0 with @entity2 than @entity0 with @entity5 in terms of the burden of family history, the frequency of complications during pregnancy and delivery, and the frequency of the subsequent early @entity6 . In terms of unfavorable life situations and @entity3 for which they were monitored in a @entity1 ward before their hospitalization with @entity4 , their data are more similar to those of @entity0 with @entity5 than with @entity2 (Tab. 3, Fig. 1, Ref. 21). KEYWORDS: adolescent, @entity5 , psychoactive drugs, substance-induced @entity4 , early onset @entity2 .

title: Comparison of history of adolescents with substance-induced @entity4 , early onset @entity2 and XXXX .

answer: @entity5


abstract: INTRODUCTION: Recent studies have shown that @entity0 with @entity3 ( @entity3 ) experience a @entity1 mood during the episode. However, little evidence has been found of possible mood congruency effects on memory, which are probably masked by the massive anterograde @entity2 . An implicit assessment could provide a means of settling this question. METHODS: First, we measured @entity0 ' emotional states on psychopathological scales. Second, we administered a lexical decision task to assess three priming effects: Semantic priming (SP; table-chair), emotional priming (EP; murder-garbage), and emotional plus semantic priming (ESP; cemetery-coffin). RESULTS: @entity0 displayed a more depressed mood than controls. For @entity0 , we found a SP effect in the ESP condition and a striking inhibition effect (i.e., negative target recognized more slowly when preceded by a negative prime rather than a neutral one) in the EP condition. For controls, a priming effect was found in the SP and ESP conditions, but not the EP condition. Finally, whereas the priming effect was greater in SP than in the other two conditions for controls, for @entity0 it was the EP condition that stood out from the other two, being the only condition that led to an inhibition effect. CONCLUSIONS: We highlighted a mood congruency effect in @entity3 which could impel @entity0 to focus their attention on negative information. While the negative valence of items always led to a slowdown in reaction times for both @entity0 and controls, attesting to a negativity bias, this bias was greater in @entity0 , leading to an inhibition effect.

title: Influence of @entity1 in  XXXX .

answer: @entity3


abstract: INTRODUCTION: Recent studies have shown that @entity0 with @entity3 ( @entity3 ) experience a @entity1 mood during the episode. However, little evidence has been found of possible mood congruency effects on memory, which are probably masked by the massive anterograde @entity2 . An implicit assessment could provide a means of settling this question. METHODS: First, we measured @entity0 ' emotional states on psychopathological scales. Second, we administered a lexical decision task to assess three priming effects: Semantic priming (SP; table-chair), emotional priming (EP; murder-garbage), and emotional plus semantic priming (ESP; cemetery-coffin). RESULTS: @entity0 displayed a more depressed mood than controls. For @entity0 , we found a SP effect in the ESP condition and a striking inhibition effect (i.e., negative target recognized more slowly when preceded by a negative prime rather than a neutral one) in the EP condition. For controls, a priming effect was found in the SP and ESP conditions, but not the EP condition. Finally, whereas the priming effect was greater in SP than in the other two conditions for controls, for @entity0 it was the EP condition that stood out from the other two, being the only condition that led to an inhibition effect. CONCLUSIONS: We highlighted a mood congruency effect in @entity3 which could impel @entity0 to focus their attention on negative information. While the negative valence of items always led to a slowdown in reaction times for both @entity0 and controls, attesting to a negativity bias, this bias was greater in @entity0 , leading to an inhibition effect.

title: Influence of XXXX in  @entity3 .

answer: @entity1


abstract: INTRODUCTION: Performance status (PS) is the only known clinical predictor of outcome in @entity0 with advanced @entity5 ( @entity5 ), although pharmacogenomic markers may also correlate with outcome. The aim of our study was to correlate clinical and pharmacogenomic measures with overall survival. METHODS: This was an IRB approved, retrospective study in which the medical records of 50 @entity0 with advanced @entity5 from 1998-2008 were reviewed, and gender, race, PS, and chemotherapy regimens were documented. Stromal expression of pharmacogenomic markers ( @entity2 , @entity6  , pAKT, and @entity4 ) was measured. Clinical factors and pharmacogenomics markers were compared to overall survival using a Cox proportional hazards model. RESULTS: Forty @entity0 received @entity3 -based therapy. Median age was 65 years. Improved PS, female gender, and @entity1 therapy were significantly associated with longer overall survival (P = 0.004, P = 0.04, and P = 0.003, respectively). Age was not associated with survival. Caucasians had better overall survival in comparison to African Americans with median survival of 14.8 months versus 10.4 months (P = 0.1). @entity0 treated with @entity3 -based therapy had better survival of 15 months versus 8 months for non- @entity3 based therapy (P = 0.01). There was no significant association between any of the pharmacogenomics markers and overall survival other than in @entity0 treated with @entity3 , in whom @entity6 negativity was strongly associated with longer survival (P = 0.007). CONCLUSION: @entity6 negativity with @entity3 therapy, @entity1 therapy, good PS, and female gender all correlated with improved overall survival in @entity0 with advanced @entity5 .

title: The use of pharmacogenomics for selection of therapy in XXXX .

answer: @entity5


abstract: BACKGROUND: @entity6 testis is a rare entity, and there are only few reports on the malignant transformation of a @entity9 to @entity7 in the literature. In this report, we describe the @entity2 testis with distant lung @entity1 associated with trisomy 17 and a coexisting @entity8 in the thyroid. CASE REPORT: A 56-year-old @entity0 presented after a left orchiectomy for an undescended left testicle. Pathologic examination identified a monodermal @entity3 composed of @entity4 and associated with a 1.7-cm @entity7 . Further evaluation showed a pulmonary mass on a chest CT scan. Total thyroidectomy revealed a 0.5-mm focus of @entity7 , and removal of the lung mass confirmed metastatic @entity7 . Array-comparative genomic hybridization of both @entity2 showed trisomy 17 in the @entity6 testes and the lung @entity1 . The @entity0 responded well to radioactive @entity5 ablation and has no evidence of @entity2 3 years later. CONCLUSION: To our knowledge, this is the first case of @entity7 in @entity6 testes metastatic to the lung. It highlights the difficulties in treating these @entity0 . Surgery to remove @entity2 foci, followed by radioactive @entity5 ablation, resulted in an excellent response in our @entity0 . Interestingly, trisomy 17, which has so far been observed only in noninvasive thyroid nodules, was associated with pulmonary @entity1 in our @entity0 .

title: XXXX in @entity6 testis with malignant transformation in the lung associated with trisomy 17 successfully treated with total thyroidectomy and radioiodine ablation.

answer: @entity7


abstract: BACKGROUND: @entity6 testis is a rare entity, and there are only few reports on the malignant transformation of a @entity9 to @entity7 in the literature. In this report, we describe the @entity2 testis with distant lung @entity1 associated with trisomy 17 and a coexisting @entity8 in the thyroid. CASE REPORT: A 56-year-old @entity0 presented after a left orchiectomy for an undescended left testicle. Pathologic examination identified a monodermal @entity3 composed of @entity4 and associated with a 1.7-cm @entity7 . Further evaluation showed a pulmonary mass on a chest CT scan. Total thyroidectomy revealed a 0.5-mm focus of @entity7 , and removal of the lung mass confirmed metastatic @entity7 . Array-comparative genomic hybridization of both @entity2 showed trisomy 17 in the @entity6 testes and the lung @entity1 . The @entity0 responded well to radioactive @entity5 ablation and has no evidence of @entity2 3 years later. CONCLUSION: To our knowledge, this is the first case of @entity7 in @entity6 testes metastatic to the lung. It highlights the difficulties in treating these @entity0 . Surgery to remove @entity2 foci, followed by radioactive @entity5 ablation, resulted in an excellent response in our @entity0 . Interestingly, trisomy 17, which has so far been observed only in noninvasive thyroid nodules, was associated with pulmonary @entity1 in our @entity0 .

title: @entity7 in XXXX testis with malignant transformation in the lung associated with trisomy 17 successfully treated with total thyroidectomy and radioiodine ablation.

answer: @entity6


abstract: Although the association between @entity0 and @entity2 is well-known, the underlying mechanism remains elusive. Previously, we have shown that 3 week fat feeding in @entity1 produces greater visceral adiposity, @entity2 , @entity4 and elevated renal sympathetic nerve activity (RSNA) compared to @entity1 on a normal diet. Because hyperinsulinaemia, hyperleptinemia, and dyslipidaemia are independent cardiovascular risk factors associated with @entity2 we compared plasma @entity6 , leptin, and lipid profiles in male New Zealand White @entity1 fed a normal fat diet (NFD 4.3% fat, n = 11) or high fat diet (HFD 13.4% fat, n = 13) at days 1, 2, 3 and weeks 1, 2, 3 of the diet. Plasma concentrations of diacylglyceride (DG), triacylglyceride (TG), @entity5 and @entity7 (CE) were obtained after analysis by liquid chromatography mass spectrometry. Plasma @entity6 and @entity3 increased within the first 3 days of the diet in HFD @entity1 (P < 0.05) and remained elevated at week 1 (P < 0.05). Blood pressure and heart rate (HR) followed a similar pattern. By contrast, in both groups, plasma leptin levels remained unchanged during the first few days (P > 0.05), increasing by week 3 in fat fed animals alone (P < 0.05). Concentrations of total DG, TG, CE, and @entity5 at week 3 did not differ between groups (P > 0.05). Our data show plasma @entity6 increases rapidly following consumption of a HFD and suggests that it may play a role in the rapid rise of blood pressure. Dyslipidaemia does not appear to contribute to the @entity2 in this animal model.

title: Short term fat feeding rapidly increases plasma XXXX but does not result in dyslipidaemia.

answer: @entity6


abstract: BACKGROUND: Delayed onset @entity4 (DOMS) occurs following unaccustomed or intense bouts of exercise. Previous research has demonstrated that that preconditioning with low load exercise or heat relieves @entity4 . However, actively warming up the muscles with exercise may be an effective alternative. OBJECTIVES: This study compared preconditioning effect of light load eccentric exercise and heat using microwave diathermy on markers of @entity1 in collegiate males. @entity0 AND METHODS: Thirty six sedentary collegiate males were randomly assigned into two experimental groups: 10% Eccentric exercise group (10% ECC group) and Microwave diathermy group (MWD group). Both the groups performed 30 repetitions of maximal eccentric exercise (Max-ECC) of the elbow flexors. The 10% ECC group performed light load eccentric exercise (10% ECC), five sets, six repetitions using a dumbbell set at 10% of maximal voluntary isometric contraction strength (MVC), 2 days prior to Max-ECC. The MWD group received heat using microwave diathermy (150 watts, 20 minutes) one day prior to Max-ECC. Changes in MVC, range of motion (ROM), upper arm circumference, soreness, were assessed before and 24-72 hours after whereas serum @entity3 kinase activity and @entity2 dehydrogenase (LDH) activity up to 48 hours following the Max-ECC were compared between groups by a mixed model ANOVA. RESULTS: No significant difference (P > 0.05) were found between the groups for changes in all variables post Max-ECC, except for LDH activity showing significant interaction effect (P = 0.04). CONCLUSIONS: Preconditioning with light load eccentric exercise and heat using microwave diathermy treatment did not differ in their effects on @entity1 markers after Max-ECC. However, with time their effects on LDH activity were found to be different.

title: Effect of preconditioning by light load eccentric exercise versus heat on markers of XXXX in collegiate males.

answer: @entity1


abstract: This retrospective cohort study of 1,345 male employees with potential for exposure to @entity2 analyzes @entity1 incidence and mortality from 1956 to 1976. Expected numbers based on company and national rates have been computed on @entity0 -years. The analyses consider calendar time, payroll classification, occupation, duration of exposure, severity of exposure, and latency. Overall, 25 cases of @entity1 occurred, with 20.5 expected based on company rates. Of these, eight were @entity1 cases, with 4.4 expected. Excesses were found primarily during the 1970-76 time period among wage roll employees who had worked during plant start-up. A trend toward increased risks was seen with increased duration and severity of exposure. Twenty @entity1 deaths were found, with 17.4 expected according to company rates. Since many @entity1 cases were recently diagnosed and are living, it may be premature to evaluate mortality statistics. These findings, coupled with results from tests in laboratory animals, raise the serious suspicion that @entity2 may be a @entity0 carcinogen.

title: Epidemiologic study of workers exposed to XXXX .

answer: @entity2


abstract: PURPOSE OF THE STUDY The aim of the study is to present the technique of pedicle subtraction osteotomy (PSO) of the seventh cervical vertebra (C7) for correction of @entity5 of the cervicothoracic junction (C/Th) in @entity0 with severe @entity4 ( @entity4 ).. MATERIAL AnD METHODS The PSO technique for correction of @entity5 of the C/Th spine was used in fie @entity0 with the aim to restore their ability of horizontal vision. The follow-up in all @entity0 lasted two years at least. Clinical assessment of treatment results was based on the @entity0 ' neurological status and their satisfaction with the correction achieved. Improvement in a vertical 2) line of sight was evaluated using the angle measured between the forehead-chin line and the vertical ( @entity7 angle) in a lateral view photograph of the standing @entity0 . The achieved correction of @entity2 was assessed by comparing the pre-operative Cobb's angle between the second cervical and the fourth thoracic vertebra with the post-operative one. RESULTS The average operative time was 4 hours (range, 3.5 to 5 h). The average @entity3 was 1600 ml (range, 800 to 2100 ml). On the average, the @entity7 angle was reduced by 45.2   and Cobb's angle was corrected) by 54.6  . All @entity0 were satisfid with the degree of correction achieved and reported alleviation of @entity6 . none of the @entity0 showed any signifiant loss of @entity1 at two-year follow-up. DISCUSSIOn The theoretical and technical principles of corrective osteotomy at the C7 level performed for @entity5 of the spine at the C/Th junction are presented in our group of @entity0 . Our results give support to the superiority of instrumented PSO used currently over the previous techniques. In accordance with the relevant literature data, attention is drawn to a relatively higher risk of this procedure in comparison with corrective surgery performed at the other spinal levels. COnCLUSIOnS Corrective osteotomy of a @entity5 at the C/Th spine level in @entity4 @entity0 involves a complex reconstructive surgical procedure. The PSO technique reduces the risk of injury to the visceral structures ventral to the spine, and provides optimal conditions for bone healing at the site of vertebral body resection. If the @entity0 heals well, a successful PSO procedure will markedly improve the quality of his/her life. Key words: corrective osteotomy, cervicothoracic, kyphosis, @entity4 .

title: [Correction of @entity2 of the cervical spine in XXXX using pedicle subtraction osteotomy of the seventh cervical vertebra].

answer: @entity4


abstract: PURPOSE OF THE STUDY The aim of the study is to present the technique of pedicle subtraction osteotomy (PSO) of the seventh cervical vertebra (C7) for correction of @entity5 of the cervicothoracic junction (C/Th) in @entity0 with severe @entity4 ( @entity4 ).. MATERIAL AnD METHODS The PSO technique for correction of @entity5 of the C/Th spine was used in fie @entity0 with the aim to restore their ability of horizontal vision. The follow-up in all @entity0 lasted two years at least. Clinical assessment of treatment results was based on the @entity0 ' neurological status and their satisfaction with the correction achieved. Improvement in a vertical 2) line of sight was evaluated using the angle measured between the forehead-chin line and the vertical ( @entity7 angle) in a lateral view photograph of the standing @entity0 . The achieved correction of @entity2 was assessed by comparing the pre-operative Cobb's angle between the second cervical and the fourth thoracic vertebra with the post-operative one. RESULTS The average operative time was 4 hours (range, 3.5 to 5 h). The average @entity3 was 1600 ml (range, 800 to 2100 ml). On the average, the @entity7 angle was reduced by 45.2   and Cobb's angle was corrected) by 54.6  . All @entity0 were satisfid with the degree of correction achieved and reported alleviation of @entity6 . none of the @entity0 showed any signifiant loss of @entity1 at two-year follow-up. DISCUSSIOn The theoretical and technical principles of corrective osteotomy at the C7 level performed for @entity5 of the spine at the C/Th junction are presented in our group of @entity0 . Our results give support to the superiority of instrumented PSO used currently over the previous techniques. In accordance with the relevant literature data, attention is drawn to a relatively higher risk of this procedure in comparison with corrective surgery performed at the other spinal levels. COnCLUSIOnS Corrective osteotomy of a @entity5 at the C/Th spine level in @entity4 @entity0 involves a complex reconstructive surgical procedure. The PSO technique reduces the risk of injury to the visceral structures ventral to the spine, and provides optimal conditions for bone healing at the site of vertebral body resection. If the @entity0 heals well, a successful PSO procedure will markedly improve the quality of his/her life. Key words: corrective osteotomy, cervicothoracic, kyphosis, @entity4 .

title: [Correction of XXXX of the cervical spine in @entity4 using pedicle subtraction osteotomy of the seventh cervical vertebra].

answer: @entity2


abstract: Graph theory-based analysis has been widely employed in brain imaging studies, and altered topological properties of brain connectivity have emerged as important features of @entity2 such as @entity1 . However, most previous studies have focused on graph metrics of stationary brain graphs, ignoring that brain connectivity exhibits fluctuations over time. Here we develop a new framework for accessing dynamic graph properties of time-varying functional brain connectivity in resting-state fMRI data and apply it to healthy controls (HCs) and @entity0 with @entity1 (SZs). Specifically, nodes of brain graphs are defined by @entity3 ( @entity3 ) identified by group independent component analysis (ICA). Dynamic graph metrics of the time-varying brain connectivity estimated by the correlation of sliding time-windowed ICA time courses of @entity3 are calculated. First- and second-level connectivity states are detected based on the correlation of nodal connectivity strength between time-varying brain graphs. Our results indicate that SZs show decreased variance in the dynamic graph metrics. Consistent with prior stationary functional brain connectivity works, graph measures of identified first-level connectivity states show lower values in SZs. In addition, more first-level connectivity states are disassociated with the second-level connectivity state which resembles the stationary connectivity pattern computed by the entire scan. Collectively, the findings provide new evidence about altered dynamic brain graphs in @entity1 , which may underscore the abnormal brain performance in this @entity2 .

title: Assessing dynamic brain graphs of time-varying connectivity in fMRI data: application to healthy controls and @entity0 with XXXX .

answer: @entity1


abstract: Graph theory-based analysis has been widely employed in brain imaging studies, and altered topological properties of brain connectivity have emerged as important features of @entity2 such as @entity1 . However, most previous studies have focused on graph metrics of stationary brain graphs, ignoring that brain connectivity exhibits fluctuations over time. Here we develop a new framework for accessing dynamic graph properties of time-varying functional brain connectivity in resting-state fMRI data and apply it to healthy controls (HCs) and @entity0 with @entity1 (SZs). Specifically, nodes of brain graphs are defined by @entity3 ( @entity3 ) identified by group independent component analysis (ICA). Dynamic graph metrics of the time-varying brain connectivity estimated by the correlation of sliding time-windowed ICA time courses of @entity3 are calculated. First- and second-level connectivity states are detected based on the correlation of nodal connectivity strength between time-varying brain graphs. Our results indicate that SZs show decreased variance in the dynamic graph metrics. Consistent with prior stationary functional brain connectivity works, graph measures of identified first-level connectivity states show lower values in SZs. In addition, more first-level connectivity states are disassociated with the second-level connectivity state which resembles the stationary connectivity pattern computed by the entire scan. Collectively, the findings provide new evidence about altered dynamic brain graphs in @entity1 , which may underscore the abnormal brain performance in this @entity2 .

title: Assessing dynamic brain graphs of time-varying connectivity in fMRI data: application to healthy controls and XXXX with @entity1 .

answer: @entity0


abstract: PURPOSE: To report a rare case of painful @entity3 after lateral medullary @entity9 and probe its underlying pathogenesis on the basis of neuroimaging and electrophysiological study. CASE REPORT: A 45-year-old @entity0 presented acute onset of unsteady gait followed by paroxysmal and @entity2 in the distribution of ophthalmic branch of left trigeminal nerve in 2 days. Neurological examinations showed @entity8 in the distribution of mandibular branch of left trigeminal nerve and @entity10 . Muscle powers and deep tendon reflexes were normal. Brain magnetic resonance imaging revealed @entity9 within the left cerebellum and middle portion of dorsolateral medulla. @entity12 at the root entry zone of trigeminal nerve was excluded. Painful @entity3 secondary to lateral medullary @entity9 was diagnosed. Ancillary blink reflex study 3 days after the @entity5 event showed abnormal late responses (R2), either ipsilateral or contralateral, after stimulation of left supraorbital nerve, suggesting left medullary lesion. Followup study 3 weeks later demonstrated normalization in absolute latencies of bilateral late responses, in line with remission of @entity6 paroxysms on low-dose @entity11 treatment. CONCLUSION: Painful @entity3 attributed to lateral medullary @entity9 is a unique disease entity. Ophthalmic branch involvement, coexisting @entity4 , absence of triggers, and rapid evolvement and remission are its characteristics. Our neuroimaging study delineated @entity7 pathology within descending tract and spinal nucleus of trigeminal nerve. Serial electrophysiological studies provide evidences supporting ephaptic transmission as the main pathogenesis concordant with dynamics of @entity1 and therapeutic implications.

title: A Rare Case of Painful XXXX Secondary to Lateral Medullary Infarct: Neuroimaging and Electrophysiological Studies.

answer: @entity3


abstract: BACKGROUND: In @entity2 in situ of the breast (DCIS), histologic diagnosis obtained before the definitive treatment is related to the risk of underestimation if the presence of @entity1 is found postoperatively. These @entity0 need a second operation to assess the nodal status. We evaluated the upstaging rate in @entity0 with mass-forming DCIS. METHODS: Sixty-three @entity0 with pure DCIS presenting as sonographic mass lesion underwent vacuum-assisted or core-needle biopsy and subsequent surgery. Rates of postoperative upstaging to @entity1 were calculated and compared with clinical character and size of DCIS. RESULTS: Median age of @entity0 (range) was 63  years (27-88) while median diameter of DCIS was 11  mm (6-60). Fifty-six percent of DCIS were upstaged. @entity0 age did not differ significantly between groups with and without final invasion (median, mean, SD): 63, 61.4, 12.5 vs 62, 61.2, 10.6  years, respectively (P   =   0.659). The difference of DCIS size between these groups was statistically important (median, mean, SD): 13, 17.3, 11.4 vs 9.5, 9.8, 3.2  mm, respectively (P   =   0.0003). Mass size and palpability were significant risk factors (P   <   0.001 and P   <   0.01, respectively). Rate of underestimation for mass with diameter  <=10  mm, 10-20  mm and >20  mm was 37, 64 and 91  %, respectively. CONCLUSIONS: DCIS diagnosed on minimal-invasive biopsy of even small sonographic mass is of high risk for the upstaging to @entity1 after final surgical excision. In these @entity0 , subsequent intervention is needed for nodal status assessment. They are good candidates for the sentinel node biopsy during the breast operation to avoid multi-step surgery.

title: Preoperatively diagnosed ductal cancers in situ of the breast presenting as even small masses are of high risk for the XXXX foci in postoperative specimen.

answer: @entity1


abstract: The relationship between cell swelling and plasma membrane disruption has been evaluated in thin @entity1 incubated in oxygenated or anoxic Krebs-Ringer phosphate media. Electron microscopy and measurements of inulin-diffusible space were used to monitor plasma membrane integrity. Inulin is excluded from the intracellular space of intact cells; therefore, an increase in tissue inulin content is an excellent marker of loss of plasma membrane integrity. Cell volume was increased during exposure of aerobic slices to @entity3 media, but the inulin-diffusible space was not increased and electron micrographs showed no detectable plasma membrane alterations. Likewise, during @entity2 , no evidence of plasma membrane damage was observed. Incubation in anoxic @entity3 media for 60 minutes resulted in a larger increase in cell volume than under aerobic conditions, but plasma membrane integrity was maintained. @entity3 (300 minutes) produced no further change in tissue water, but the inulin-diffusible space was increased and electron micrographs revealed breaks in the plasma membranes primarily in association with large subsarcolemmal blebs. Likewise, @entity1 incubated in isotonic anoxic media for 240 minutes and @entity3 anoxic media for 60 minutes had an increased inulin-diffusible space and the ultrastructural appearance was similar. This ultrastructural appearance is indistinguishable from that observed in myocytes lethally injured by @entity0 . Measurements of tissue osmolarity during total @entity0 showed that osmotically induced cell swelling could occur in @entity0 prior to the onset of plasma membrane disruption. Our results indicate that cell swelling per se is incapable of rupturing plasma membranes; however, after prolonged periods of @entity4 , the plasma membrane or its cytoskeletal scaffold become injured, which allows the membrane to rupture if the cell is swollen, as might occur during @entity0 or reperfusion.

title: Volume regulation and plasma membrane injury in aerobic, anaerobic, and XXXX in vitro. Effects of osmotic cell swelling on plasma membrane integrity.

answer: @entity0


abstract: BACKGROUND: Tympanometry and pneumatic otoscopy are recommended for diagnosis of @entity3 media, but are not frequently used by general practitioners (GPs). We examined how, after targeted short training, GP diagnosis and management of @entity1 was changed by the addition of these techniques to non-pneumatic otoscopy. We further explored factors influencing the uptake of these techniques. METHODS: Between 2011 and 2012, we used a crossover experimental design to determine associations between tympanometry and pneumatic otoscopy and the GP diagnosis and management of @entity1 in @entity0 aged 6  months to 6  years. GPs recorded a diagnosis and management plan after examining ears using non-pneumatic otoscopy, and another after using either tympanometry or pneumatic otoscopy. We compared diagnosis, prescription of oral antibiotics and planned GP follow-up at these two steps between the tympanometry and pneumatic otoscopy groups. We interviewed @entity0 about their views regarding these techniques and analysed these data thematically. RESULTS: Thirteen GPs recorded 694 ear examinations on 347 @entity0 : 347 examinations with non-pneumatic otoscopy; then 196 using tympanometry; and 151 using pneumatic otoscopy. Tympanometry was more likely to be associated with changes in diagnosis (   (2)   =   28.64, df 1, p   <   0.001) and planned GP follow-up (   (2)   =   9.24, df 1, p   <   0.01) than pneumatic otoscopy. Change in oral antibiotic prescription was no different between the two techniques. GPs preferred tympanometry to pneumatic otoscopy, but cost was a barrier to ongoing use. Pneumatic otoscopy was considered the more difficult skill. GPs were not convinced that the increased detection of @entity2 afforded by tympanometry and pneumatic otoscopy resulted in benefit to general practice @entity0 . CONCLUSION: Tympanometry was more likely than pneumatic otoscopy to change GP diagnoses and follow-up plans of @entity1 . Tympanometry may require less training than pneumatic otoscopy. GPs preferred tympanometry due to ease of use and interpretation; however, perceived high cost inhibited their intent to use it in the future. Training, cost and perceived lack of @entity0 benefit are barriers to the use of tympanometry and pneumatic otoscopy in general practice.

title: The effect and acceptability of tympanometry and pneumatic otoscopy in general practitioner diagnosis and management of XXXX .

answer: @entity1