abstract: OBJECTIVE: This prospective study was to observe the correlation between the @entity1 's height of single implant-supported maxillary central incisor and the distance from the base of the contact point to the alveolar bone crest. METHODS: 56 @entity0 involved in single implant-supported maxillary central incisor were included in this study. The distances from the base of the contact point to the alveolar bone crest in the digital periapical film of maxillary central incisor were measured using the software Planmeca Dimaxis Version 3.3.2. The time of measurements were as follows: The pre-surgical and post-surgical periods, before and after the crown installation, the follow-up examination of more than 0.5 year. To analyze the factor of influencing distance, and the correlation between the distance and the height of @entity2 during the whole restored period. Correlation analysis between the distance and the height of @entity2 during the whole restoration was done by the statistical software SPSS 12.0. RESULTS: The results demonstrated that the ratio of esthetic papilla can achieve 54.5% at the crown installation and 95.5% at the follow-up examination when the distance was between 3 mm and 5 mm. When the distance was between 5 mm and 6 mm, they dropped to 30.0% and 75.0%, respectively. However, when the distance increased to above 7 mm, the papilla could hardly be in an esthetic outcome. There was a significant change of the distance was found during the periods from the post-surgery to pre-restoration, and the scope of the changes was between -0.13 mm and 0.46 mm. A negative correlation was found between the distance and the index of papilla. The correlation coefficient r was -0.715 (P < 0.01). CONCLUSION: It is proposed that the pre-surgery distance of maxillary central incisor from the base of the contact point to the alveolar bone crest can be used as one of the important reference indexes to assess and predict the height conditions of @entity2 .

title: [Assessment research on the inter-proximal XXXX height of single implant-supported maxillary central incisor].

answer: @entity1


abstract: PURPOSE: @entity1 represent a heterogeneous group of primary high-grade @entity4 , and the optimal postoperative treatment remains controversial. In this report, we present our institutional data on the clinical outcomes of @entity3 ( @entity3 ) plus temozolomide ( @entity3  +  TMZ) for @entity1 , stratified by histology and 1p/19q codeletion. METHODS AND MATERIALS: A single-institution retrospective review was conducted of @entity0 with supratentorial @entity7 ( @entity7 ), mixed @entity2 ( @entity2 ), and @entity2 ( @entity2 ). After surgery, @entity3 was delivered at a median total dose of 60  Gy (range, 31.6-63  Gy) in daily fractions. All @entity0 received standard concurrent TMZ, with or without adjuvant TMZ. Histological/molecular subtypes were defined as codeleted @entity7 / @entity2 , non-codeleted @entity7 / @entity2 , and @entity2 . RESULTS: From 2000 to 2012, 111 cases met study criteria and were evaluable. Codeleted @entity7 / @entity2 had superior @entity5 ( @entity5 ) to non-codeleted @entity7 / @entity2 (91% vs 68% at 5  years, respectively, P=.02), whereas progression-free survival (PFS) was not significantly different (70% vs 46% at 5  years, respectively, P=.10). @entity2 had inferior @entity5 to non-codeleted @entity7 / @entity2 (37% vs 68% at 5  years, respectively, P=.007) and inferior PFS (27% vs 46%, respectively, P=.03). On multivariate analysis, age, performance status, and histological or molecular subtype were independent predictors for both PFS and @entity5 . Compared to historical controls, @entity3  +  TMZ provided comparable @entity5 to @entity3 with procarbazine, lomustine, and vincristine ( @entity3  +  @entity6 ) for codeleted @entity7 / @entity2 , superior @entity5 to @entity3 alone for non-codeleted @entity7 / @entity2 , and similar @entity5 to @entity3 alone for @entity2 . CONCLUSIONS: @entity3  +  TMZ may be a promising treatment for both codeleted and non-codeleted @entity7 / @entity2 , but its role for @entity2 remains unclear.

title: Impact of 1p/19q codeletion and histology on outcomes of XXXX treated with @entity3 and temozolomide.

answer: @entity1


abstract: PURPOSE: @entity1 represent a heterogeneous group of primary high-grade @entity4 , and the optimal postoperative treatment remains controversial. In this report, we present our institutional data on the clinical outcomes of @entity3 ( @entity3 ) plus temozolomide ( @entity3  +  TMZ) for @entity1 , stratified by histology and 1p/19q codeletion. METHODS AND MATERIALS: A single-institution retrospective review was conducted of @entity0 with supratentorial @entity7 ( @entity7 ), mixed @entity2 ( @entity2 ), and @entity2 ( @entity2 ). After surgery, @entity3 was delivered at a median total dose of 60  Gy (range, 31.6-63  Gy) in daily fractions. All @entity0 received standard concurrent TMZ, with or without adjuvant TMZ. Histological/molecular subtypes were defined as codeleted @entity7 / @entity2 , non-codeleted @entity7 / @entity2 , and @entity2 . RESULTS: From 2000 to 2012, 111 cases met study criteria and were evaluable. Codeleted @entity7 / @entity2 had superior @entity5 ( @entity5 ) to non-codeleted @entity7 / @entity2 (91% vs 68% at 5  years, respectively, P=.02), whereas progression-free survival (PFS) was not significantly different (70% vs 46% at 5  years, respectively, P=.10). @entity2 had inferior @entity5 to non-codeleted @entity7 / @entity2 (37% vs 68% at 5  years, respectively, P=.007) and inferior PFS (27% vs 46%, respectively, P=.03). On multivariate analysis, age, performance status, and histological or molecular subtype were independent predictors for both PFS and @entity5 . Compared to historical controls, @entity3  +  TMZ provided comparable @entity5 to @entity3 with procarbazine, lomustine, and vincristine ( @entity3  +  @entity6 ) for codeleted @entity7 / @entity2 , superior @entity5 to @entity3 alone for non-codeleted @entity7 / @entity2 , and similar @entity5 to @entity3 alone for @entity2 . CONCLUSIONS: @entity3  +  TMZ may be a promising treatment for both codeleted and non-codeleted @entity7 / @entity2 , but its role for @entity2 remains unclear.

title: Impact of 1p/19q codeletion and histology on outcomes of @entity1 treated with XXXX and temozolomide.

answer: @entity3


abstract: A method is described for the simultaneous determination of major glucocorticoids in @entity0 plasma, that is, @entity2 , @entity7 and @entity3 , which includes @entity6 by high-pressure liquid chromatography and measurement using a UV detector (254 nm). Chromatography on the Zorbax CN column is carried out with the eluent system, that is, @entity4 / @entity5 (=87/13 v/v). First, @entity1 was selected as the best internal standard under the previously mentioned conditions. The calibration curves for the glucocorticoids were all clearly linear. The recoveries for each 5 ng of added @entity2 , @entity7 and @entity3 were 96.7 +/- 3.2%, 100.4 +/- 2.3% and 96.1 +/- 2.2%, respectively. The reproducibility of @entity2 was good and its coefficient of variation of intraassay was small (2.7%), whereas such coefficient was not so in @entity7 (7.7%) and @entity3 (7.3%). This appears to be due to low concentrations of @entity7 and @entity3 in the plasma. Specificity of this method to each glucocorticoid was ascertained using plasma from adrenalectomized wethers. In addition, the correlation coefficient between measurements of @entity2 by radioimmunoassay and those by this method was 0.978. In conclusion, the method described in this paper appears to be satisfactory for the simultaneous quantification of plasma glucocorticoids.

title: [Simultaneous determination of glucocorticoids in XXXX plasma by high-pressure liquid chromatography].

answer: @entity0


abstract: RATIONALE AND OBJECTIVES: To assess the sensitivity and utility of multiphase pulsed arterial @entity5 labeling (PASL) in detecting dynamic changes of cerebral perfusion in the presence of a @entity3 ( @entity3 ) severe @entity1 . MATERIALS AND METHODS: Seventeen @entity0 with severe stenoses in unilateral M1 segment of @entity3 were involved in this study. All @entity0 underwent multiphase PASL imaging. Bilateral basal ganglia were drawn by hand as regions of interest (ROIs) on eight-phase images of each @entity0 . The signal intensities of ROIs were measured and the @entity2 ( @entity2 ) were acquired through postprocessing on a magnetic resonance workstation. Whether there was a significant difference in the peak signal intensities of ROIs between the narrowed and normal sides was determined by the paired samples t test. RESULTS: Three types of @entity2 were observed: eight cases with platform type, five cases with two-peak type, and four cases with single-peak type. There was a significant difference in the peak signal intensities of ROIs between the narrowed and normal sides. CONCLUSIONS: Different types of @entity2 represent different cerebral hemodynamic changes. Multiphase PASL can sensitively detect the dynamic characteristics of cerebral perfusion and provide important dynamic perfusion information for clinical treatment of @entity4 .

title: Multiphase Arterial XXXX Labeling Assessment of Cerebral Perfusion Changes Associated with @entity3 .

answer: @entity5


abstract: RATIONALE AND OBJECTIVES: To assess the sensitivity and utility of multiphase pulsed arterial @entity5 labeling (PASL) in detecting dynamic changes of cerebral perfusion in the presence of a @entity3 ( @entity3 ) severe @entity1 . MATERIALS AND METHODS: Seventeen @entity0 with severe stenoses in unilateral M1 segment of @entity3 were involved in this study. All @entity0 underwent multiphase PASL imaging. Bilateral basal ganglia were drawn by hand as regions of interest (ROIs) on eight-phase images of each @entity0 . The signal intensities of ROIs were measured and the @entity2 ( @entity2 ) were acquired through postprocessing on a magnetic resonance workstation. Whether there was a significant difference in the peak signal intensities of ROIs between the narrowed and normal sides was determined by the paired samples t test. RESULTS: Three types of @entity2 were observed: eight cases with platform type, five cases with two-peak type, and four cases with single-peak type. There was a significant difference in the peak signal intensities of ROIs between the narrowed and normal sides. CONCLUSIONS: Different types of @entity2 represent different cerebral hemodynamic changes. Multiphase PASL can sensitively detect the dynamic characteristics of cerebral perfusion and provide important dynamic perfusion information for clinical treatment of @entity4 .

title: Multiphase Arterial @entity5 Labeling Assessment of Cerebral Perfusion Changes Associated with XXXX .

answer: @entity3


abstract: UNASSIGNED: The demand for vaccines against @entity1 has enforced the research and development of @entity4 -like particle (VLP) based vaccine candidates in recent years. Significant progress has been made in increasing VLP titres during upstream processing in bacteria, @entity2 and insect cells. Considering downstream processing, the separation of host cell impurities is predominantly achieved by time-intensive ultracentrifugation processes or numerous chromatography and filtration steps. In this work, we evaluate the potential of an alternative separation technology for VLPs: aqueous two-phase extraction ( @entity6 ). The benefits of @entity6 have been demonstrated for various biomolecules, but capacity and separation efficiency were observed to be low for large biomolecules such as VLPs or viruses. Both performance parameters were examined in detail in a case study on @entity0 B19 parvovirus-like particles derived from Spodoptera frugiperda Sf9 insect cells. A solubility-guided approach enabled the design of @entity3 ( @entity5 ) salt aqueous two-phase systems with a high capacity of up to 4.1mg/mL VLPs. Unique separation efficiencies were obtained by varying the molecular weight of @entity5 , the pH value and by using neutral salt additives. Further improvement of the separation of host cell impurities was achieved by multi-stage @entity6 on a centrifugal partition chromatography (CPC) device in 500mL scale. While single-stage @entity6 enabled a DNA clearance of 99.6%, multi-stage @entity6 improved the separation of host cell proteins (HCPs). The HPLC purity ranged from 16.8% (100% VLP recovery) for the single-stage @entity6 to 69.1% (40.1% VLP recovery) for the multi-stage @entity6 . An alternative two-step downstream process is presented removing the ATPS forming polymer, cell debris and 99.77% DNA with a HPLC purity of 90.6% and a VLP recovery of 63.9%.

title: Downstream processing of XXXX -like particles: Single-stage and multi-stage aqueous two-phase extraction.

answer: @entity4


abstract: BACKGROUND _ AIMS: The beneficial effect of nonselective beta-blockers (NSBB) has recently been questioned in @entity0 with end-stage @entity1 . We analysed the impact of NSBB on outcomes in severe @entity2 ( @entity2 ). METHODS: This study was based on a prospective database of @entity0 with severe, biopsy-proven @entity2 . @entity0 admitted from July, 2006 to July, 2014 were retrospectively studied. @entity0 were divided into two groups (with and without NSBB) and assessed for the occurrence of @entity3 ( @entity3 ) and transplant-free mortality during a 168-day follow-up period. RESULTS: One hundred thirty-nine @entity0 were included, the mean Maddrey score was 71      34 and 86 @entity0 (61.9%) developed @entity3 . Forty-eight @entity0 (34.5%) received NSBB. The overall 168-day transplant-free mortality was 50.5% (95%CI, 41.3-60.0%). The overall 168-day cumulative incidence of @entity3 was 61.9% (95%CI, 53.2-69.4%). When compared, @entity0 with NSBB had a lower heart rate (65      13 vs 92      12, P  <  0.0001) and a lower mean arterial pressure (MAP, 78      3 vs 87      5, P  <  0.0001). @entity0 with NSBB had comparable MELD scores, Maddrey scores, and medical histories. The 168-day transplant-free mortality was 56.8% (95%CI, 41.3-69.7%) in @entity0 with NSBB and 46.7% (95%CI, 35.0-57.6%) without NSBB (P  =  0.25). The 168-day cumulative incidence of @entity3 was 89.6% (95%CI, 74.9-95.9%) with NSBB compared to 50.4% (95%CI: 39.0-60.7) for no NSBB (P  =  0.0001). The independent factors predicting @entity3 were a higher MELD score and the presence of NSBB. CONCLUSIONS: The use of NSBB in @entity0 with severe @entity2 is independently associated with a higher cumulative incidence of @entity3 .

title: The use of beta-blockers is associated with the occurrence of @entity3 in severe XXXX .

answer: @entity2


abstract: BACKGROUND _ AIMS: The beneficial effect of nonselective beta-blockers (NSBB) has recently been questioned in @entity0 with end-stage @entity1 . We analysed the impact of NSBB on outcomes in severe @entity2 ( @entity2 ). METHODS: This study was based on a prospective database of @entity0 with severe, biopsy-proven @entity2 . @entity0 admitted from July, 2006 to July, 2014 were retrospectively studied. @entity0 were divided into two groups (with and without NSBB) and assessed for the occurrence of @entity3 ( @entity3 ) and transplant-free mortality during a 168-day follow-up period. RESULTS: One hundred thirty-nine @entity0 were included, the mean Maddrey score was 71      34 and 86 @entity0 (61.9%) developed @entity3 . Forty-eight @entity0 (34.5%) received NSBB. The overall 168-day transplant-free mortality was 50.5% (95%CI, 41.3-60.0%). The overall 168-day cumulative incidence of @entity3 was 61.9% (95%CI, 53.2-69.4%). When compared, @entity0 with NSBB had a lower heart rate (65      13 vs 92      12, P  <  0.0001) and a lower mean arterial pressure (MAP, 78      3 vs 87      5, P  <  0.0001). @entity0 with NSBB had comparable MELD scores, Maddrey scores, and medical histories. The 168-day transplant-free mortality was 56.8% (95%CI, 41.3-69.7%) in @entity0 with NSBB and 46.7% (95%CI, 35.0-57.6%) without NSBB (P  =  0.25). The 168-day cumulative incidence of @entity3 was 89.6% (95%CI, 74.9-95.9%) with NSBB compared to 50.4% (95%CI: 39.0-60.7) for no NSBB (P  =  0.0001). The independent factors predicting @entity3 were a higher MELD score and the presence of NSBB. CONCLUSIONS: The use of NSBB in @entity0 with severe @entity2 is independently associated with a higher cumulative incidence of @entity3 .

title: The use of beta-blockers is associated with the occurrence of XXXX in severe @entity2 .

answer: @entity3


abstract: The substantia nigra pars reticulata (SNPR) has previously been shown to undergo tissue @entity1 following @entity2 induced by @entity8 in the @entity0 . Even if the @entity0 is ventilated, the SNPR develops @entity1 if the @entity4 period lasts more than 30 min. @entity0 brains were frozen in situ after 20 and 60 min of @entity5 activity and after 60 min of @entity5 activity followed by 60 min recovery. Labile energy metabolites were then analyzed in the SNPR and in the periaqueductal grey matter (PAG, control region). In the PAG, the metabolite changes during @entity2 were similar to those reported for cerebral cortex and hippocampus. Measurements showed an unchanged @entity6 content and energy charge (97% and 98% of control, respectively) and an accumulation of @entity7 to 9.2 +/- 0.6 mumol/g in the 60-min group. In the PAG, all metabolites measured had returned to control values after 60 min of recovery. In the SNPR, the perturbation of the energy metabolites was much more pronounced during @entity2 . The concentration of @entity6 decreased to 75 +/- 3%, the energy charge to 91% +/- 12% and the adenylate pool to 86.7 +/- 5.7% of control. @entity7 accumulated to concentrations of 16.1 +/- 1.8 mumol/g and 24.9 +/- 2.3 mumol/g in the 20-min and 60-min groups, respectively. The concentration of @entity7 was still increased above control after 60 min recovery, whereas the concentration of @entity6 and the energy charge were lower than control. The findings demonstrate that sustained and intense neuronal activation can cause @entity3 and thereby lead to @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Metabolic alterations underlying the development of @entity1 in the substantia nigra in XXXX .

answer: @entity2


abstract: The substantia nigra pars reticulata (SNPR) has previously been shown to undergo tissue @entity1 following @entity2 induced by @entity8 in the @entity0 . Even if the @entity0 is ventilated, the SNPR develops @entity1 if the @entity4 period lasts more than 30 min. @entity0 brains were frozen in situ after 20 and 60 min of @entity5 activity and after 60 min of @entity5 activity followed by 60 min recovery. Labile energy metabolites were then analyzed in the SNPR and in the periaqueductal grey matter (PAG, control region). In the PAG, the metabolite changes during @entity2 were similar to those reported for cerebral cortex and hippocampus. Measurements showed an unchanged @entity6 content and energy charge (97% and 98% of control, respectively) and an accumulation of @entity7 to 9.2 +/- 0.6 mumol/g in the 60-min group. In the PAG, all metabolites measured had returned to control values after 60 min of recovery. In the SNPR, the perturbation of the energy metabolites was much more pronounced during @entity2 . The concentration of @entity6 decreased to 75 +/- 3%, the energy charge to 91% +/- 12% and the adenylate pool to 86.7 +/- 5.7% of control. @entity7 accumulated to concentrations of 16.1 +/- 1.8 mumol/g and 24.9 +/- 2.3 mumol/g in the 20-min and 60-min groups, respectively. The concentration of @entity7 was still increased above control after 60 min recovery, whereas the concentration of @entity6 and the energy charge were lower than control. The findings demonstrate that sustained and intense neuronal activation can cause @entity3 and thereby lead to @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Metabolic alterations underlying the development of XXXX in the substantia nigra in @entity2 .

answer: @entity1


abstract: UNASSIGNED: Previous research has suggested that @entity0 meeting criteria for @entity1 ( @entity1 ) display altered self-related information processing. However, experimental studies on dysfunctional self-referential information processing in @entity1 are rare. In this study, @entity1 @entity0 (N = 30) and healthy control @entity0 (N = 30) judged positive, neutral, and negative words in terms of emotional valence. Referential processing was manipulated by a preceding self-referential pronoun, an other-referential pronoun, or no referential context. Subsequently, @entity0 and @entity0 completed a free recall and recognition task. @entity1 @entity0 judged positive and neutral words as more negative than healthy control @entity0 when the words had self-reference or no reference. In @entity1 @entity0 , these biases were significantly correlated with self-reported attributional style, particularly for negative events, but unrelated to measures of depressive mood. However, @entity1 @entity0 did not differ from healthy control @entity0 in a subsequent free recall task and a recognition task. Our findings point to a negative evaluation bias for positive, self-referential information in @entity1 . This bias did not affect the storage of information in memory, but may be related to self-attributions of negative events in everyday life in @entity1 .

title: Negative Evaluation Bias for Positive Self-Referential Information in XXXX .

answer: @entity1


abstract: In growing animals, requirements for many nutrients (and energy) are determined by the retention of these nutrients. During growth, this retention changes in an absolute way and also between nutrients and energy, resulting in changing nutrient requirements. The objective of this study was to describe the changes in chemical composition in male growing @entity0 . The serial slaughter technique was used to determine the composition of @entity3 , lipid, ash, and water in feather-free body (FFB) and feathers in male @entity0 offered feed ad libitum from 1 to 15 wk of age. Allometric relations were used to describe changes in body composition. The feather content in the body decreased from 6% at 1 wk of age to less than 3% at 15 wk of age. The water and protein content in FFB decreased with increasing FFB mass, with allometric scalars (b) of, respectively, 0.967 and 0.970, whereas the lipid content increased with increasing FFB mass (b = 1.388). The water, protein, and ash content in fat-free FFB was constant and represented, respectively, 71.6, 24.2, and 4.2% of the fat-free FFB mass. The @entity2 content of FFB protein was relatively constant and only the @entity4 content decreased between 1 and 15 wk of age, whereas the Ile content increased. Feathers were mostly composed of protein, and the protein content did not change during growth. During growth, the Lys, Met, Trp, His, Tyr, @entity5 , and @entity1 contents in feather protein decreased, whereas the @entity4 , @entity6 , and Ser contents increased. The contribution of feathers to whole-body @entity2 retention ranged from 5% for His to 33% for @entity4 . On average, the weight gain of FFB contained 21.3% protein and 12.7% lipid, corresponding to an energy content of 10.1 kJ/g. The weight gain of feathers contained 87.4% protein, corresponding to an energy content of 20.4 kJ/g. The results of the present study can be used in a factorial approach to determine nutrient requirements in growing @entity0 .

title: Changes in chemical composition in male XXXX during growth.

answer: @entity0


abstract: The medical consequences of elevated @entity1 are widely known, as are the medical regimens to control and manage it. At the same time, elevated @entity1 is bereft of bodily signs. Being symptomless places the condition in a no @entity0 's land: @entity0 with elevated @entity1 are assessed as medically sick but their bodies signal wellness. In this article I refer to this ambiguous grey area, betwixt and between being healthy and being sick, as liminal space . The aim of this article is to show how @entity0 manage the symptomless condition of elevated @entity1 in liminal space. Particular attention is paid to everyday medical reasoning in that space. Based on interviews with @entity0 with elevated @entity1 , I show that medical regimens are 'up against' - challenged by - a variety of competing conditions in everyday life, illustrating ambiguity. Facing this dilemma between medicine and everyday life, they ongoingly need to navigate - edit, modify, adjust - medical regimens against everyday conditions. This navigating work can be seen as ritualized strategies to sort ambiguity. @entity0 with elevated @entity1 do not so much act 'against medical regimens' as they simultaneously need to take account of other matters they are up against in trying to stay healthy. Medical regimens are sometimes central, sometimes peripheral. Adapting medical regimens to the situation at hand, @entity0 continuously comply with medical regimens, producing and reproducing medical regimens in moral contexts of everyday life.

title: 'I take a small amount of the real product': Elevated XXXX and everyday medical reasoning in liminal space.

answer: @entity1


abstract: PURPOSE: To evaluate the impact of a proactive surveillance program on functional access rate at the time of first dialysis. METHODS: In January 2010, a proactive surveillance program to intercept failures to mature was set up at the University Hospitals Leuven. @entity0 receiving an @entity3 ( @entity3 ) for pre-dialysis @entity2 between January 2010 and May 2013 were retrospectively analyzed. The primary end-point was a functional @entity3 at first dialysis. Also, @entity3 - associated complications and reinterventions were analyzed. Furthermore, primary, assisted primary and secondary patency rates were estimated using Kaplan-Meier survival curves. RESULTS: One hundred sixty-four @entity0 were included in the study. @entity0 were followed until first dialysis. Median follow-up time was 287 days (interquartile range, 108-551 days). During follow-up, 40 @entity0 (24.4%) needed one or more additional interventions, resulting in 60 reinterventions. Ten @entity0 needed dialysis within the minimal accepted maturation period of the @entity3 (4 weeks). Of the 154 @entity0 who could await the maturation period of the @entity3 , 145 (94.2%) appeared ready for use at the time of dialysis or at the end of the study period. In 34 of them (22%), this was thanks to one or more interventions during follow-up. CONCLUSIONS: A dedicated surveillance program of @entity0 with AVFs in the pre-dialysis stadium detects failure to mature. Close @entity4 and proactive intervention can aid the @entity0 in his own " @entity1 first" project.

title: Proactive surveillance approach to guarantee a functional XXXX at first dialysis is worth.

answer: @entity3


abstract: OBJECTIVE: The objective of this study was to assess the outcomes of the prenatal diagnosis of @entity4 in fetuses referred for prenatal imaging with a finding of @entity3 . MATERIALS AND METHODS: This study is a retrospective review of fetuses with a diagnostic code of @entity4 from a larger prospective study. Four hundred twenty-five pregnant @entity0 with 433 fetuses referred for @entity3 were imaged with ultrasound and MRI between July 1, 2003, and May 15, 2009. Four to six radiologists independently reviewed sonographic and MR images and recorded lateral ventricular diameters at the atrium and frontal horns, ventricular configuration, and the presence of @entity1 . Final prenatal ultrasound, MRI, and overall diagnoses were decided by consensus. Fetuses with a diagnostic code of @entity4 were identified, and birth outcome, autopsy findings, postnatal imaging, and postnatal follow-up examinations were obtained. The analysis of covariance, controlling for gestational age, was used to compare ventricular dimensions between fetuses with @entity4 and fetuses with isolated @entity3 . Interrater agreement for the detection of @entity4 was assessed with kappa statistics. Interrater agreement and intrarater agreement for frontal horn measurements were assessed by variance components analysis. RESULTS: Twenty-three fetuses had @entity4 and 229 had isolated @entity3 . Atrial and frontal horn diameters, adjusted for gestational age, were 77% and 98% larger, respectively, in fetuses with @entity4 than in fetuses with isolated @entity3 (p < 0.0001). Before the consensus conference, agreement among ultrasound readers was moderate (k = 0.54) and among MR readers, good (k = 0.69). Additional CNS findings were seen on MRI in 12 of 23 fetuses (52%). Eleven pregnancies with @entity4 underwent termination and 12 progressed to livebirth; of the 12 livebirths, three neonates died. Neurodevelopmental follow-up was abnormal in all surviving @entity0 . CONCLUSION: A septal leaflet abnormality in the setting of @entity3 is most frequently associated with other @entity1 and is associated with @entity2 .

title: Outcome of fetuses with cerebral XXXX and septum pellucidum leaflet abnormalities.

answer: @entity3


abstract: BACKGROUND AND AIMS: Risk factors for @entity3 ( @entity3 ) are not well understood. The aim of this systematic review was to assess if @entity1 , smoking, @entity2 use, and family history of @entity0 are risk factors for @entity3 . METHODS: MEDLINE and abstracts from the European and North American @entity0 Societies (ENETS and NANETS) were searched for studies published until October 2013. Eligible studies were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. RESULTS: Five studies evaluating 4 individual populations were included (study accrual period 2000-2011) into the meta-analysis, involving 827 cases (range 160-309 per study) and 2,407 controls (range 233-924 per study). All studies had a case-control design and described regional series. The pooled adjusted odds ratio was 2.74 (95% CI: 1.63-4.62; p < 0.01; I(2) = 60.4%) for history of @entity1 , 1.21 (95% CI: 0.92-1.58; p = 0.18; I(2) = 45.8%) for ever smoking, 1.37 (95% CI: 0.99-1.91; p = 0.06; I(2) = 0.0%) for heavy smoking, 1.09 (95% CI: 0.64-1.85; p = 0.75; I(2) = 85.2%) for ever @entity2 use, 2.72 (95% CI: 1.25-5.91; p = 0.01; I(2) = 57.8%) for heavy @entity2 use, and 2.16 (95% CI: 1.64-2.85; p < 0.01; I(2) = 0.0%) for first-degree family history of @entity0 . CONCLUSIONS: @entity1 and first-degree family history of @entity0 are associated with an increased risk of @entity4 . There was also a trend for diagnosis of @entity4 associated with heavy smoking. @entity2 use may be a risk factor for @entity4 , but there was considerable heterogeneity in the meta-analysis. These results suggest the need for a larger, homogeneous, international study for the clarification of risk factors for the occurrence of @entity4 .    2015 S. Karger AG, Basel.

title: @entity1 , Smoking, @entity2 Use, and Family History of Cancer as Risk Factors for XXXX : A Systematic Review and Meta-Analysis.

answer: @entity3


abstract: BACKGROUND AND AIMS: Risk factors for @entity3 ( @entity3 ) are not well understood. The aim of this systematic review was to assess if @entity1 , smoking, @entity2 use, and family history of @entity0 are risk factors for @entity3 . METHODS: MEDLINE and abstracts from the European and North American @entity0 Societies (ENETS and NANETS) were searched for studies published until October 2013. Eligible studies were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. RESULTS: Five studies evaluating 4 individual populations were included (study accrual period 2000-2011) into the meta-analysis, involving 827 cases (range 160-309 per study) and 2,407 controls (range 233-924 per study). All studies had a case-control design and described regional series. The pooled adjusted odds ratio was 2.74 (95% CI: 1.63-4.62; p < 0.01; I(2) = 60.4%) for history of @entity1 , 1.21 (95% CI: 0.92-1.58; p = 0.18; I(2) = 45.8%) for ever smoking, 1.37 (95% CI: 0.99-1.91; p = 0.06; I(2) = 0.0%) for heavy smoking, 1.09 (95% CI: 0.64-1.85; p = 0.75; I(2) = 85.2%) for ever @entity2 use, 2.72 (95% CI: 1.25-5.91; p = 0.01; I(2) = 57.8%) for heavy @entity2 use, and 2.16 (95% CI: 1.64-2.85; p < 0.01; I(2) = 0.0%) for first-degree family history of @entity0 . CONCLUSIONS: @entity1 and first-degree family history of @entity0 are associated with an increased risk of @entity4 . There was also a trend for diagnosis of @entity4 associated with heavy smoking. @entity2 use may be a risk factor for @entity4 , but there was considerable heterogeneity in the meta-analysis. These results suggest the need for a larger, homogeneous, international study for the clarification of risk factors for the occurrence of @entity4 .    2015 S. Karger AG, Basel.

title: @entity1 , Smoking, XXXX Use, and Family History of Cancer as Risk Factors for @entity3 : A Systematic Review and Meta-Analysis.

answer: @entity2


abstract: BACKGROUND AND AIMS: Risk factors for @entity3 ( @entity3 ) are not well understood. The aim of this systematic review was to assess if @entity1 , smoking, @entity2 use, and family history of @entity0 are risk factors for @entity3 . METHODS: MEDLINE and abstracts from the European and North American @entity0 Societies (ENETS and NANETS) were searched for studies published until October 2013. Eligible studies were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. RESULTS: Five studies evaluating 4 individual populations were included (study accrual period 2000-2011) into the meta-analysis, involving 827 cases (range 160-309 per study) and 2,407 controls (range 233-924 per study). All studies had a case-control design and described regional series. The pooled adjusted odds ratio was 2.74 (95% CI: 1.63-4.62; p < 0.01; I(2) = 60.4%) for history of @entity1 , 1.21 (95% CI: 0.92-1.58; p = 0.18; I(2) = 45.8%) for ever smoking, 1.37 (95% CI: 0.99-1.91; p = 0.06; I(2) = 0.0%) for heavy smoking, 1.09 (95% CI: 0.64-1.85; p = 0.75; I(2) = 85.2%) for ever @entity2 use, 2.72 (95% CI: 1.25-5.91; p = 0.01; I(2) = 57.8%) for heavy @entity2 use, and 2.16 (95% CI: 1.64-2.85; p < 0.01; I(2) = 0.0%) for first-degree family history of @entity0 . CONCLUSIONS: @entity1 and first-degree family history of @entity0 are associated with an increased risk of @entity4 . There was also a trend for diagnosis of @entity4 associated with heavy smoking. @entity2 use may be a risk factor for @entity4 , but there was considerable heterogeneity in the meta-analysis. These results suggest the need for a larger, homogeneous, international study for the clarification of risk factors for the occurrence of @entity4 .    2015 S. Karger AG, Basel.

title: XXXX , Smoking, @entity2 Use, and Family History of Cancer as Risk Factors for @entity3 : A Systematic Review and Meta-Analysis.

answer: @entity1


abstract: INTRODUCTION: Intubation injury resulting in laryngeal pathology is recognised as a possible complication of @entity3 , yet few published studies have examined such pathology and its relation to voice outcomes. This study reports on the results of prospective laryngeal function examinations of a cohort of very preterm @entity0 , all of whom presented with significant @entity4 at school age. MATERIALS AND METHODS: The laryngeal pathology of 20 very preterm @entity0 , born between 23 and 29 weeks gestation, was examined under halogen and stroboscopic conditions. Laryngeal structure and function were assessed using a rigid laryngoscope or a flexible nasendoscope. The approach was selected based on the age and/or likely compliance of the @entity0 . RESULTS: Nineteen @entity0 were found to have structural laryngeal pathology. Fourteen @entity0 presented with a chink to the posterior glottis and all demonstrated at least a mild degree of @entity5 . Other common findings were arytenoid prolapse and vocal fold immobility. More isolated findings included @entity2 , @entity1 and growth on the vocal folds. One @entity0 who presented with structural laryngeal pathology was never intubated. DISCUSSION: Supraglottic hyperfunction was common to all @entity0 , regardless of the nature and extent of underlying structural laryngeal pathology. Posterior glottic chink was the most common pattern of incomplete vocal fold closure. These data support the hypothesis that very preterm @entity0 adopt supraglottic tightening to compensate for underlying laryngeal pathology. The mechanism underlying laryngeal damage in the @entity0 who was not intubated is unclear. CONCLUSIONS: Voice quality of very preterm @entity0 is affected by both laryngeal structure and function. A trial of behavioural voice treatment is recommended to evaluate any therapeutic response in this population.

title: Laryngeal pathology at school age following very XXXX .

answer: @entity3


abstract: OBJECTIVE: To study the feasibility, safety and validity of percutaneous angioplasty and stenting (PTAS) for symptomatic @entity6 of basilar artery. METHODS: The results of treatment and follow-up of 40 cases with symptomatic @entity6 of basilar artery performed PTAS from August 2003 to December 2009 were studied retrospectively, who had either recurrent transient @entity2 attacks (TIAs) or obvious @entity2 symptoms and resistant to medical therapy. RESULTS: PTAS were successfully performed in all the 40 cases and the post-operative average residual stenosis descended to 14%    11% from pre-operative 82%    14%. After operation the @entity0 were administrated with antiplatelet drugs. After procedure the clinic symptoms and signs of @entity2 were improved obviously in 38 cases and deteriorated in 2 cases whose CT scanning showed that the range of @entity7 in brain stem enlarged. The symptoms improved after treatment but 2 @entity0 had @entity1 . No @entity5 occurred in the group. During the follow-up for 2 months to 7 years, transcranial doppler ultrasonography in 26 cases demonstrated the blood flow was faster than normal in 2 cases, and digital subtraction angiography (DSA) in 6 cases showed @entity3 in 1 case. The second stent was implanted because of the symptomatic restenosis. In another case the follow-up DSA showed @entity4 in-stent but there was no @entity2 of post circulation because the generation of anastomoses. CONCLUSIONS: PTAS is a feasible, safe and effective therapeutic method for the @entity0 with symptomatic @entity6 of basilar artery. Further study in large number of @entity0 is needed for long-term outcome.

title: [Clinical study on endovascular treatment for symptomatic XXXX of basilar artery].

answer: @entity6


abstract: OBJECTIVE: To investigate the value of protective stoma in intersphincteric resection (ISR) for ultra-low @entity1 . METHODS: Clinical data of 56 ultra-low @entity1 @entity0 without involvement of external anal sphincter treated during January 1999 to July 2009 with trans-anal ISR plus trans-abdominal total mesorectum excision and coloanal @entity2 were retrospectively analyzed. The @entity0 were divided into two groups based on whether they received protective ostomy: ostomy group (16 cases) and ostomy-free group (40 cases). The @entity3 as well as anal functional restoration were compared between the two groups. RESULTS: Sixteen cases (32.1%) of the 56 @entity0 received protective stoma. The complication rate of @entity2 and anus complication rate in the ostomy-free group were significantly higher than those in ostomy group [35.0% (14/40) and 40.0% (16/40) vs. 1/16 and 1/16; P < 0.05]. In the ostomy-free group, one @entity0 developed @entity5 dehiscence and @entity1 recurrence, the @entity0 was given permanent colostomy, and the other three @entity0 with lesions in the @entity2 and @entity6 and secondary surgical treatment, with a reoperation rate of 10.0% (4/40). The anal function of @entity0 in the two groups were both decreased after the operation. The rate of @entity0 got Kirwan grade I anal sphincter function in the 3rd, 6th and 12th month after protective stoma operation was 11/16, 13/15 and 11/13 in the ostomy group, respectively; and those were 30.0%, 37.5% and 45.0% in the ostomy-free group, respectively. Anal function was significantly better in the ostomy group than that in the ostomy-free group during the same postoperative period (P < 0.05). CONCLUSION: Protective stoma can avoid @entity5 following ISR for ultra-low @entity1 , and alleviate the suffering of anal @entity4 in the early postoperative period, and is conducive to the restoration of anal function.

title: [Value of protective stoma in intersphincteric resection for ultra-low XXXX ].

answer: @entity1


abstract: Pathological studies would aid in finding the real causes of @entity3 and in outlining adequate strategies for treatment regarding @entity0 with poor clinical outcome of influenza A H1N1 @entity10 flu. We describe the autopsy findings of six cases of influenza A H1N1 @entity10 flu. The lungs in these cases had an @entity12 with hyaline membranes. Immunohistochemistry for influenza was positive only in lungs (in pneumocytes, in macrophages, in some multinucleate cells in alveoli, and in blood vessel walls) of two cases. @entity7 was observed in four of the cases and focally in one case. Focal @entity11 was observed in one case. Coagulation @entity8 ( @entity2 ) were observed in the pancreas of two cases and in the spleen of two cases. Our results indicate that there was marked replication of the virus in alveoli in the more recently infected cases, which could explain the extensive @entity1 . In our cases, there were important vascular phenomena that resulted in @entity5 and @entity6 , but without marked @entity9 and coagulation cascade disruptions. This would be attributed to hemodynamic disruption. However, it is possible that the @entity5 in the brain are due to @entity4 or to an increase of endothelial permeability.

title: Pathology of the XXXX -origin influenza A (H1N1) flu.

answer: @entity10


abstract: BACKGROUND: Pancreatic body and tail ductal @entity5 are often diagnosed with local vascular invasion of the @entity9 ( @entity9 ) and its various branches. With such involvement, these @entity1 have traditionally been considered unresectable. The modified Appleby procedure allows for margin negative resection of some such locally advanced @entity1 . This procedure involves distal pancreatectomy with en bloc splenectomy and @entity9 resection and relies on the presence of collateral arterial circulation via an intact pancreaticoduodenal arcade and the gastroduodenal artery to maintain prograde hepatic arterial perfusion. When the resultant collateral circulation is inadequate to provide sufficient hepatic and gastric arterial inflow, @entity6 ( @entity6 ) is necessary to "supercharge" the inflow. Herein, we review all reported cases of @entity6 with modified Appleby procedures that we have identified in the literature, and we report our experience of three recent cases with @entity6 including two cases with arterial bypasses not requiring interposition grafting. METHODS: Perioperative and oncologic outcomes from our Institutional Review Board-approved database of pancreatic resections at the Thomas Jefferson University were reviewed. Additionally, PubMed search for cases of distal or total pancreatectomy with @entity9 resection and concurrent @entity6 was performed. RESULTS: From the literature, 12 reports involving 28 @entity0 were identified of distal and total pancreatectomy with @entity6 after @entity9 resection. The most common @entity6 in the literature, performed in 12 @entity0 , was a bypass from the aorta to the @entity3 ( @entity3 ) using a variety of interposition conduits. In our institutional experience, @entity0 #1 had a primary side-to-end aorto- @entity3 bypass, @entity0 #2 had a primary end-to-end bypass of the transected distal @entity3 in the setting a replaced left hepatic artery, and @entity0 #3 required an aortic to proper hepatic artery bypass with saphenous vein graft and portal venous reconstruction. All @entity0 recovered from their operations without @entity2 complications, and they are currently 16, 15, and 13  months post-op, respectively. CONCLUSIONS: The criteria for resectability in @entity0 with locally advanced pancreatic body and tail @entity1 are expanding due to increasing experience with @entity6 in the setting of the modified Appleby procedure. When performing @entity6 , primary arterial re- @entity4 may be considered preferable to interposition grafting as it decreases the potential for the infectious and @entity7 complications associated with conduits and it reduces the number of vascular anastomoses from two to one. Consideration must also be given to normal variant anatomy of the hepatic circulation during operative planning as the origin of the left gastric artery is resected with the @entity9 . The modified Appleby procedure with @entity6 , when used in appropriately selected @entity0 , offers the potential for safe, margin negative resection of locally advanced @entity8 .

title: Modified Appleby Procedure with Arterial Reconstruction for Locally Advanced XXXX : A Literature Review and Report of Three Unusual Cases.

answer: @entity8


abstract: INTRODUCTION: We reviewed the functional outcome of 68 @entity0 with open @entity1 managed in an orthoplastic specialist centre. MATERIALS AND METHODS: @entity0 managed at Frenchay Hospital over a 6 year period were divided into 3 groups: group P were @entity0 initially seen and managed at Frenchay Hospital (an orthoplastic specialist centre), group S were @entity0 stabilised at a different unit and referred for definitive management, while group R were @entity0 managed in a different unit and referred following complications. Injuries were graded using the AO score and outcome was measured using the Enneking score (both validated). RESULTS: 19 @entity0 (group P, mean age: 43 years), 26 @entity0 (group S, mean age: 41 years) and 23 @entity0 (group R, mean age: 41.9 years) made the cohort. 82.4% @entity0 required free tissue transfer. Mean AO scores of groups P, S and R were 11.5, 12.3 and 9.7 (p+0.03). Mean number of procedures for P, S and R were 2.6, 3.5 and 4.2 (p=0.0006). Mean follow up time was 55.5, 61.0 and 57.0 weeks respectively (p=0.72). Mean Enneking scores for groups P, S and R were 63.3, 74.8 and 73.5 (p=0.16). CONCLUSION: @entity0 from groups S and R underwent more procedures. However, a similar outcome can be achieved, highlighting the importance of managing such injuries in an orthoplastic specialist centre.

title: Outcome of the management of open XXXX in an ortho-plastic specialist centre.

answer: @entity1


abstract: BACKGROUND: We assessed whether the iScore could predict the need for poststroke institutional care. METHODS: @entity0 with acute @entity3 living in Dijon, France, were recorded between 2006 and 2011, using a population-based @entity1 registry. The iScore was calculated for each @entity0 . A logistic regression model was used to assess the performance of the iScore for predicting the need for placement in a care institution. The discrimination and calibration of the model were assessed using the c statistic and the Hosmer-Lemeshow goodness-of-fit test, respectively. RESULTS: Of the 1199 @entity0 recorded, 124 were excluded because of early @entity2 and 95 because of missing for variables included in the iScore. Of the remaining 980 @entity0 , 522 (53.3%) returned home and 458 (46.7%) required placement in a care institution. The median iScore was 123 (interquartile range, 97-148), and the proportion of @entity0 who required placement in a care institution increased with each quintile of risk score. The discrimination of the model was good with a c statistic of .75 (95% confidence interval, .72-.78), as was calibration (P  =  .35). CONCLUSIONS: The iScore could be useful for predicting the need for placement in a care institution  in @entity3 @entity0 . Further studies are required to confirm this finding.

title: iScore for Predicting Institutional Care after XXXX . A Population-Based Study.

answer: @entity3


abstract: UNASSIGNED: The objective of the present work was to study syntopy of the @entity0 using block-preparations of the posterior cranial fossa, variants of its branching-off from the vertebro-basiliar basin (VBB), and peculiar features of its anatomical structure. A total of 12 block-preparations of the posterior cranial fossa were available for the investigation. They were preliminarily stained with red latex and fixed in a three-point system. These procedures were followed by retrosigmoid craniotomy, opening of dura mater in the supero-lateral part of the cerebellomedulllary cistern, traction of the cerebellum, and blunt separation of the basiliar artery (BA). Variants of @entity1 from @entity1 were studied. It was shown that the @entity1 in 100% of the cases. The latter artery formed a loop in 14% of the cases (3 ears). The average diameter of the labyrinth artery was 0.32 mm and its mean area 0.06 sq.cm. The @entity0 branched off from the posterior para-stem segment of the @entity1 in 42.6% of the cases (9 ears), and from the anterior para-stem segment of @entity1 in 14.2% of the cases (3 ears). Within the conventional   rhombus  , the @entity0 was straight in 76.2% of the cases (16 ears) and arc-shaped in 23.8% (4 ears).

title: [The specific features of the anatomical structure of the XXXX (an anatomical and topographical study)].

answer: @entity0


abstract: A 61-year-old and right handed @entity0 was admitted to our department on August 11, 1980. The @entity0 had three month history of focal fits, progressive @entity4 , and motor dominant @entity5 . The neuroradiological examination revealed a space taking lesion at the left frontoparietal area, which showed a small @entity1 stain with early filled draining vein on the left carotid angiogram, and iso-high dense mass with marked contrast enhancement on the CT scan. The EEG findings showed polymorphous delta rhythm in the left frontal and parietal areas. On August 28, total @entity1 was performed. The @entity1 was a intracerebral, fibrous @entity6 without involvement of the pia and dura mater. The removed @entity1 was measured approximately 6 X 5 X 4 cm in size, and consistence of the @entity1 was mostly elastic hard and partially soft and hemorrhagic. Histologically, the @entity1 composed of an admixture of bizarre histiocytes and fibroblasts, multinucleated giant cells, xanthoma cells and siderophages, with @entity2 . After surgery, no distinct lesion was demonstrated on the whole body CT scan and garium and @entity3 scintigram in the abdomen and the lung. The right @entity4 and @entity5 were improved gradually, and the @entity0 discharged on December 20, 1980. We discussed the origin of this @entity1 , and angiographic and CT scan findings on the literature.

title: [Intracerebral XXXX --report of a case].

answer: @entity2


abstract: BACKGROUND: @entity3 ( @entity3 ) is the preferred study of choice for pectoralis major @entity2 . Because this is a rare injury, no large case series have evaluated the efficacy of @entity3 for diagnosing and characterizing pectoralis major @entity2 . We hypothesized that @entity3 would be accurate for diagnosis of the location and grade of pectoralis major tears. METHODS: The study included 36 operative cases of pectoralis major @entity2 with detailed descriptions of tear location and grade and satisfactory preoperative MRIs. Two musculoskeletal fellowship-trained radiologists interpreted the MRIs, which were then compared with the operative findings for location: @entity0 or myotendinous junction, and tear grade (G): G2 (incomplete high grade partial tear) or G3 (complete tear). The sensitivity, specificity, positive predictive value, and negative predictive value were calculated. RESULTS: The @entity3 sensitivity was 1.00 for diagnosing complete G3 tears at the sternal head and clavicular head in acute @entity2 . The sensitivity of @entity3 for diagnosing @entity0 at the sternal and clavicular heads was 0.93 and 0.90, respectively. The sensitivity of @entity3 in diagnosing myotendinous and G2 tears diminishes, but specificity and negative predictive value remain high for sternal and clavicular @entity1 . CONCLUSIONS: Our data support the use of @entity3 in diagnosing the tear grade and location of pectoralis major @entity2 , particularly for acute, tendon-bone, and G3 tears. The diagnostic accuracy of @entity3 decreases when chronic tears are evaluated. @entity3 remains a useful adjunct in diagnosing and guiding treatment of pectoralis major @entity2 .

title: Accuracy of magnetic resonance imaging in predicting the intraoperative tear characteristics of pectoralis major XXXX .

answer: @entity2


abstract: BACKGROUND: One quarter of @entity3 @entity0 will present with liver @entity1 at the time of diagnosis. Recent studies have shown that simultaneous resections are safe and feasible for stage IV @entity4 . Limited data are available for simultaneous surgery in @entity2 @entity0 . METHODS: One hundred ninety-eight @entity0 underwent surgical treatment for @entity2 . In 145 (73%) @entity0 , a simultaneous procedure was performed. Fifty-three (27%) @entity0 underwent staged liver resection. A subpopulation of 69 (35%) @entity0 underwent major liver resection (3  segments or more) and 30 (44%) @entity0 with simultaneous surgery. RESULTS: The demographics of the 2 groups were similar. Complication rates were comparable for simultaneous or staged resections, even in the group subjected to major liver resection. Total hospital stay was significantly shorter for the simultaneously resected @entity0 (P < .01). CONCLUSIONS: Simultaneous resection of rectal primaries and liver metastases is a safe procedure in carefully selected @entity0 at high-volume institutions, even if major liver resections are required.

title: Simultaneous resection for XXXX with synchronous liver metastasis is a safe procedure.

answer: @entity2


abstract: AIM: To study a role of long-term stress and endothelial function in the development of @entity5 ( @entity5 ) in young @entity0 . MATERIAL AND METHODS: Authors examined 75 male @entity0 , aged from 17 to 28 years, with @entity5 including 41 @entity0 without clinically evident symptoms of @entity4 (group I) and 34 @entity0 with high level of @entity4 (group II). A comparison group consisted of 21 healthy volunteers. The level of @entity2 was assessed using the Spilberger-Khanin Inventory and the functional state of endothelium with the use of endothelium-dependent vasodilatation (EDV). Standard bicycle physical exercise (PE) test was performed. RESULTS: Correlations between state and trait @entity2 in all groups were shown. In group II, these values were maximal thus demonstrating marked @entity2 . In EDV and PE tests, @entity0 of group I had general reactivity of the vascular wall, while @entity0 of group II showed opposite reactions, either increase or decrease in the brachial artery diameter. This instability may result from the increased liability of the sympathetic part of the autonomic nervous system in stress conditions. CONCLUSION: Long-term stress causes vascular @entity3 in young @entity0 with @entity5 that increases the severity of clinical manifestations of the disease and leads to the increased risk of @entity1 .

title: [A role of long-term stress and functional properties of the endothelium in the development of XXXX ].

answer: @entity5


abstract: UNASSIGNED: Poor insight has a negative impact on the outcome in @entity2 ; consequently, poor insight is a logical target for treatment. However, neither medication nor psychosocial interventions have been demonstrated to improve poor insight. A method originally designed for @entity1 @entity0 to improve their illness management, Guided Self-Determination (GSD), has been adapted for use in @entity0 with @entity2 (GSD-SZ). The purpose of this study was to investigate the effect on insight of GSD-SZ as a supplement to treatment as usual ( @entity3 ) as compared to @entity3 alone in outpatients diagnosed with @entity2 . The design was an open randomized trial. The primary hypothesis was cognitive insight would improve in those @entity0 who received GSD-SZ+ @entity3 as assessed by the BCIS. We additionally explored whether the intervention led to changes in clinical insight, self-perceived recovery, self-esteem, social functioning and symptom severity. Assessments were conducted at baseline, and at 3-, 6- and 12-month follow-up. Analysis was based on the principles of intention to treat and potential confounders were taken into account through applying a multivariate approach. A total of 101 @entity0 were randomized to GSD-SZ+ @entity3 (n=50) or to @entity3 alone (n=51). No statistically significant differences were found on the cognitive insight. However, at 12-month follow-up, clinical insight (measured by G12 from the Positive and Negative Syndrome Scale), symptom severity, and social functioning had statistically significantly improved in the intervention group as compared to the control group. "Improving insight in @entity0 diagnosed with @entity2 ", NCT01282307, http://clinicaltrials.gov/.

title: Effects on cognitive and clinical insight with the use of Guided Self-Determination in outpatients with XXXX : A randomized open trial.

answer: @entity2


abstract: UNASSIGNED: Experiences of violence may have considerable psychosocial and health implications. A violence screening tool was implemented in the German Health Interview and Examination Survey for Adults ( @entity2 ) to depict the perpetrators' and victims' point of view. The study @entity0 were between 18 and 64 years old (n   =   5939). The aim of this article is to assess the percentage of @entity0 who experienced physical and @entity1 in the last 12 months or who suffered negative effects on their quality of life as a consequence or who were perpetrators of multiple acts of violence. The characteristics of victims, offenders, and their conflict partners are described. Furthermore, specific constellations of violence experience with regard to health-related quality of life are described. Finally, the association between being a victim of violence and different factors is estimated.In total, 2.7   % of @entity0 and 4.3   % of @entity0 reported multiple experiences of physical violence in the last 12 months or having their lives negatively impacted as a consequence of violence. Experience of @entity1 was reported by 18.9   % of @entity0 and 15.4   % of @entity0 . @entity0 are more likely than @entity0 to be both perpetrator and victim within the family. @entity0 are more likely than @entity0 to be both the perpetrator and victim outside of the family environment. Regardless of whether they are the victim or perpetrator of violence, the psychological well-being is significantly worse than those of @entity0 who did not experience violence. Experience of violence in childhood and adolescence increases the risk of becoming victim or perpetrator of violence later on in life. The findings presented here describe the psychological and physical experience of violence as one part of violence committed in the whole population. Some prevention advice is also presented.

title: [Prevalence of experience of physical and @entity1 in the general population in the past 12 months : Results of the German Health Interview and Examination Survey for Adults ( XXXX )].

answer: @entity2


abstract: UNASSIGNED: Experiences of violence may have considerable psychosocial and health implications. A violence screening tool was implemented in the German Health Interview and Examination Survey for Adults ( @entity2 ) to depict the perpetrators' and victims' point of view. The study @entity0 were between 18 and 64 years old (n   =   5939). The aim of this article is to assess the percentage of @entity0 who experienced physical and @entity1 in the last 12 months or who suffered negative effects on their quality of life as a consequence or who were perpetrators of multiple acts of violence. The characteristics of victims, offenders, and their conflict partners are described. Furthermore, specific constellations of violence experience with regard to health-related quality of life are described. Finally, the association between being a victim of violence and different factors is estimated.In total, 2.7   % of @entity0 and 4.3   % of @entity0 reported multiple experiences of physical violence in the last 12 months or having their lives negatively impacted as a consequence of violence. Experience of @entity1 was reported by 18.9   % of @entity0 and 15.4   % of @entity0 . @entity0 are more likely than @entity0 to be both perpetrator and victim within the family. @entity0 are more likely than @entity0 to be both the perpetrator and victim outside of the family environment. Regardless of whether they are the victim or perpetrator of violence, the psychological well-being is significantly worse than those of @entity0 who did not experience violence. Experience of violence in childhood and adolescence increases the risk of becoming victim or perpetrator of violence later on in life. The findings presented here describe the psychological and physical experience of violence as one part of violence committed in the whole population. Some prevention advice is also presented.

title: [Prevalence of experience of physical and XXXX in the general population in the past 12 months : Results of the German Health Interview and Examination Survey for Adults ( @entity2 )].

answer: @entity1


abstract: UNASSIGNED:     Introduction: Intraperitoneal @entity2 is a potential option for the treatment of @entity0 ( @entity0 )-associated @entity0 caused by microorganisms resistant to commonly used antibiotics. However, the stability of @entity2 must be assessed in the @entity0 solution before evaluating its safety and therapeutic efficacy in @entity0 -associated @entity0 . The objective of this study was to investigate the stability of @entity2 in 3 types of @entity0 solutions at different temperatures for various time points.     Methods: A total of 27 @entity0 bags (9 @entity0 bags for each type of @entity0 solution; 1.5% @entity1 , 7.5% icodextrin, and 1.5% @entity1 pH neutral) containing 2  g/mL of @entity2 were prepared and stored at either 4, 25, @entity3 . An aliquot was withdrawn immediately before (0 hour) and after pre-defined time points. Each sample was analyzed in duplicate for the concentration of @entity2 using a stability-indicating high-performance liquid chromatography (HPLC) technique. Samples were also assessed for pH, color changes, and evidence of precipitation immediately after preparation and on each day of analysis.     Results: @entity2 in all 3 types of @entity0 solutions retained more than 90% of its initial concentration for at least 216, 72, and 8hours at 4, 25, and 37  C, respectively. There was no evidence of precipitation at any time under the tested storage conditions. The pH and color of @entity2 admixed @entity0 solutions stored at 4, 25, and 37  C remained essentially unchanged for 336, 96, and 48hours respectively.     Conclusion: The results obtained from the study provide a platform for future clinical studies aiming to determine the safety and therapeutic efficacy of intraperitoneally administered @entity2 for the treatment of @entity0 -associated @entity0 .

title: STABILITY OF XXXX IN DIFFERENT TYPES OF PERITONEAL DIALYSIS SOLUTIONS.

answer: @entity2


abstract: UNASSIGNED: Elastic light single-scattering spectroscopy system (ELSSS) is a biomedical tool which is used for detection of cancerous tissues ex-vivo. ELSSS spectra depend primarily on the size of scatterers in the tissue and are not directly related to changes in the absorption which are caused by variations of the biological macromolecules. In the present study, we aimed to detect @entity1 in the pelvic lymph node by using combination of Principal Components Analysis (PCA) and @entity3 ( @entity3 ). Single-scattering spectra in the 450-750nm wavelength regions were obtained from the total of 83 reactive lymph node and 12 metastatic lymph node samples from 10 @entity2 @entity0 . The ELSSS spectral data were compared against the "gold standard" histopathology results. Data analyses were done via using PCA, followed by @entity3 . Receiver Operating Characteristic (ROC) curve analysis was employed for differentiating performance. The classification based on discriminant score provided sensitivity of 100% and specificity of 96.4%, in differentiating non-metastatic (reactive) from metastatic pelvic lymph nodes, with a Positive Predictive Value ( @entity4 ) of 0.8, a Negative Predictive Value (NPV) of 0.99 and the area under the ROC curve (AUC) of 0.99, respectively. In this study, it was shown that ELSSS system can accurately distinguish reactive and metastatic pelvic lymph nodes of @entity2 with high @entity4 and NPV. It can be concluded that diagnostic accuracy of ELSSS system allows detecting metastatic tissues during operation.

title: Diagnosis of pelvic lymph node @entity1 in XXXX using single optical fiber probe.

answer: @entity2


abstract: UNASSIGNED: Elastic light single-scattering spectroscopy system (ELSSS) is a biomedical tool which is used for detection of cancerous tissues ex-vivo. ELSSS spectra depend primarily on the size of scatterers in the tissue and are not directly related to changes in the absorption which are caused by variations of the biological macromolecules. In the present study, we aimed to detect @entity1 in the pelvic lymph node by using combination of Principal Components Analysis (PCA) and @entity3 ( @entity3 ). Single-scattering spectra in the 450-750nm wavelength regions were obtained from the total of 83 reactive lymph node and 12 metastatic lymph node samples from 10 @entity2 @entity0 . The ELSSS spectral data were compared against the "gold standard" histopathology results. Data analyses were done via using PCA, followed by @entity3 . Receiver Operating Characteristic (ROC) curve analysis was employed for differentiating performance. The classification based on discriminant score provided sensitivity of 100% and specificity of 96.4%, in differentiating non-metastatic (reactive) from metastatic pelvic lymph nodes, with a Positive Predictive Value ( @entity4 ) of 0.8, a Negative Predictive Value (NPV) of 0.99 and the area under the ROC curve (AUC) of 0.99, respectively. In this study, it was shown that ELSSS system can accurately distinguish reactive and metastatic pelvic lymph nodes of @entity2 with high @entity4 and NPV. It can be concluded that diagnostic accuracy of ELSSS system allows detecting metastatic tissues during operation.

title: Diagnosis of pelvic lymph node XXXX in @entity2 using single optical fiber probe.

answer: @entity1


abstract: AIM: @entity1 is a known cardiac toxin and heavy consumption can lead to @entity2 ( @entity2 ). However, the relationship between moderate @entity1 consumption and risk for @entity2 , in either @entity0 or @entity0 , remains unclear. METHODS AND RESULTS: We examined 14 629 @entity0 of the @entity3 Risk in Communities (ARIC) study (54    6 years, 55% @entity0 ) without prevalent @entity2 at baseline (1987-89) who were followed for 24    1 years. Self-reported @entity1 consumption was assessed as the number of drinks/week (1 drink = 14 g of @entity1 ) at baseline, and updated cumulative average @entity1 intake was calculated over 8.9    0.3 years. Using multivariable Cox proportional hazards models, we examined the relation of @entity1 intake with incident @entity2 and assessed whether associations were modified by sex. Overall, most @entity0 were abstainers (42%) or former drinkers (19%), with 25% reporting up to 7 drinks per week, 8% reporting >= 7 to 14 drinks per week, and 3% reporting >= 14-21 and >= 21 drinks per week, respectively. Incident @entity2 occurred in 1271 @entity0 and 1237 @entity0 . @entity0 consuming up to 7 drinks/week had reduced risk of @entity2 relative to abstainers (hazard ratio, HR 0.80, 95% CI 0.68-0.94, P = 0.006); this effect was less robust in @entity0 (HR 0.84, 95% CI 0.71-1.00, P = 0.05). In the higher drinking categories, the risk of @entity2 was not significantly different from abstainers, either in @entity0 or in @entity0 . CONCLUSION: In the community, @entity1 consumption of up to 7 drinks/week at early-middle age is associated with lower risk for future @entity2 , with a similar but less definite association in @entity0 than in @entity0 . These findings suggest that despite the dangers of heavy drinking, modest @entity1 consumption in early-middle age may be associated with a lower risk for @entity2 .

title: XXXX consumption and risk of @entity2 : the @entity3 Risk in Communities Study.

answer: @entity1


abstract: AIM: @entity1 is a known cardiac toxin and heavy consumption can lead to @entity2 ( @entity2 ). However, the relationship between moderate @entity1 consumption and risk for @entity2 , in either @entity0 or @entity0 , remains unclear. METHODS AND RESULTS: We examined 14 629 @entity0 of the @entity3 Risk in Communities (ARIC) study (54    6 years, 55% @entity0 ) without prevalent @entity2 at baseline (1987-89) who were followed for 24    1 years. Self-reported @entity1 consumption was assessed as the number of drinks/week (1 drink = 14 g of @entity1 ) at baseline, and updated cumulative average @entity1 intake was calculated over 8.9    0.3 years. Using multivariable Cox proportional hazards models, we examined the relation of @entity1 intake with incident @entity2 and assessed whether associations were modified by sex. Overall, most @entity0 were abstainers (42%) or former drinkers (19%), with 25% reporting up to 7 drinks per week, 8% reporting >= 7 to 14 drinks per week, and 3% reporting >= 14-21 and >= 21 drinks per week, respectively. Incident @entity2 occurred in 1271 @entity0 and 1237 @entity0 . @entity0 consuming up to 7 drinks/week had reduced risk of @entity2 relative to abstainers (hazard ratio, HR 0.80, 95% CI 0.68-0.94, P = 0.006); this effect was less robust in @entity0 (HR 0.84, 95% CI 0.71-1.00, P = 0.05). In the higher drinking categories, the risk of @entity2 was not significantly different from abstainers, either in @entity0 or in @entity0 . CONCLUSION: In the community, @entity1 consumption of up to 7 drinks/week at early-middle age is associated with lower risk for future @entity2 , with a similar but less definite association in @entity0 than in @entity0 . These findings suggest that despite the dangers of heavy drinking, modest @entity1 consumption in early-middle age may be associated with a lower risk for @entity2 .

title: @entity1 consumption and risk of XXXX : the @entity3 Risk in Communities Study.

answer: @entity2


abstract: AIM: @entity1 is a known cardiac toxin and heavy consumption can lead to @entity2 ( @entity2 ). However, the relationship between moderate @entity1 consumption and risk for @entity2 , in either @entity0 or @entity0 , remains unclear. METHODS AND RESULTS: We examined 14 629 @entity0 of the @entity3 Risk in Communities (ARIC) study (54    6 years, 55% @entity0 ) without prevalent @entity2 at baseline (1987-89) who were followed for 24    1 years. Self-reported @entity1 consumption was assessed as the number of drinks/week (1 drink = 14 g of @entity1 ) at baseline, and updated cumulative average @entity1 intake was calculated over 8.9    0.3 years. Using multivariable Cox proportional hazards models, we examined the relation of @entity1 intake with incident @entity2 and assessed whether associations were modified by sex. Overall, most @entity0 were abstainers (42%) or former drinkers (19%), with 25% reporting up to 7 drinks per week, 8% reporting >= 7 to 14 drinks per week, and 3% reporting >= 14-21 and >= 21 drinks per week, respectively. Incident @entity2 occurred in 1271 @entity0 and 1237 @entity0 . @entity0 consuming up to 7 drinks/week had reduced risk of @entity2 relative to abstainers (hazard ratio, HR 0.80, 95% CI 0.68-0.94, P = 0.006); this effect was less robust in @entity0 (HR 0.84, 95% CI 0.71-1.00, P = 0.05). In the higher drinking categories, the risk of @entity2 was not significantly different from abstainers, either in @entity0 or in @entity0 . CONCLUSION: In the community, @entity1 consumption of up to 7 drinks/week at early-middle age is associated with lower risk for future @entity2 , with a similar but less definite association in @entity0 than in @entity0 . These findings suggest that despite the dangers of heavy drinking, modest @entity1 consumption in early-middle age may be associated with a lower risk for @entity2 .

title: @entity1 consumption and risk of @entity2 : the XXXX Risk in Communities Study.

answer: @entity3


abstract: UNASSIGNED: Leptin exerts both stimulatory and inhibitory effects on the ovulatory process. In this study, we investigated whether these opposite effects involve changes in the oxidative status in response to different levels of leptin. To this end, we performed both in vivo and in vitro assays using ovaries of immature @entity0 primed with gonadotropins to induce ovulation. Superoxide dismutase (SOD) and catalase ( @entity4 ) activity, lipid peroxidation, glutathione (GSH) content, and reactive oxygen species (ROS) were studied as oxidative damage-related parameters. The expression of @entity1 , @entity2 , and @entity3 were measured by western blot as apoptosis-related biomarkers. The acute treatment with leptin, which inhibits ovulation, decreased SOD activity and increased active @entity3 expression. No differences were found in @entity4 activity, lipid peroxidation, or total GSH. In contrast, the daily administration of leptin, which induces ovulation, decreased GSH content, ROS levels, and @entity2 and active @entity3 expression, but caused no changes in other parameters. In addition, the daily administration of leptin induced follicular growth, measured by the number of antral follicles in ovarian sections. Using ovarian explant cultures, we found increased @entity1 expression and decreased SOD activity at low and high concentrations of leptin respectively. Thus, leptin can modulate the oxidative status of the ovarian tissue, during the ovulatory process, by acting on different targets according to its circulating levels. At low concentration, leptin seems to play a protective role against the oxidative stress, whereas at high concentrations, this protein seems to be involved in cell death.

title: Regulation of the ovarian oxidative status by leptin during the ovulatory process in XXXX .

answer: @entity0


abstract: OBJECTIVES: The computer-assisted version of a self-triage tool (ca-ISET) for an ophthalmic @entity1 ( @entity1 ) was developed to increase the validity of the triage procedure when trained @entity1 staff is absent. METHODS: We tested whether sensitivity, specificity, Negative Predictive Value (NPV) and Positive Predictive Value ( @entity2 ) of the ca-ISET deviated from regular triage. @entity0 >= 18 years visiting the @entity1 of the Rotterdam Eye Hospital in the Netherlands were invited to participate in this prospective study. This @entity1 focuses on eye-related problems. @entity0 recruitment was carried out during working hours. The ca-ISET is a touch operated software application and the algorithm of the triage is based in the Manchester triage system. For all @entity0 three triage scores were determined by (1) the @entity0 using the ca-ISET; (2) triage by a regular, trained triage assistant and (3) triage by one physician who was specially trained in ophthalmic triage. The diagnosis of the physician was chosen as the reference standard to define criterion validity. The order of triage administration was alternated per @entity0 . Only cases with triage scores from the two triage systems and the reference standard were included. The outcome variables, four triage colours, were transformed into a binary score: high urgent and low urgent. The difference between the ca-ISET and regular triage in terms of sensitivity, specificity, NPV and @entity2 was tested by Z-scores. RESULTS: Of 247 eligible @entity0 , data was elicited from 189 @entity0 (average age 54 years, range 18-89). The sensitivity of the ca-ISET (0.89, CI: 0.75-0.96) did not differ from the sensitivity of the regular triage (0.69, CI: 0.53-0.82, Z=1.74, p=0.08). The ca-ISET was less specific (0.78, CI: 0.71-0.84) than the regular triage (0.92, CI=0.86-0.95, Z=3.04, p=0.00). We found no significant difference between the ca-ISET and regular triage for @entity2 (Z=0.19, p=0.85) and NPV (Z=0.03, p=0.98). CONCLUSIONS: The sensitivity, @entity2 and NPV of the ca-ISET does not differ from the sensitivity of the regular triage, while the ca-ISET retained a reasonable level of specificity. Therefore the ca-ISET can be recommended as a tool for ophthalmic emergency departments, and could be used when trained @entity1 staff is absent.

title: Criterion validity of a computer-assisted instrument of self-triage (ca-ISET) compared to the validity of regular triage in an ophthalmic XXXX .

answer: @entity1


abstract: OBJECTIVES: @entity3 has been found to co-occur with psychosocial job stress. However, different conceptualizations of job stress exist, each emphasizing different aspects of the work environment, and it is unknown which of these aspects show the strongest associations with @entity3 . Further, these associations may differ for white-collar vs. blue-collar job types, but this has not been tested. The present study examined the independent and combined contributions of Effort-RewardImbalance (ERI), Job-Demand-Control (JDC) and Organizational Justice (OJ) to @entity3 symptoms among white- and blue-collar workers. METHODS: @entity0 of a cross-sectional study (n=1634) completed validated questionnaires measuring ERI, JDC, and OJ, and reported the frequency of @entity2 during the previous year at four anatomical locations (lower back, neck or shoulder, arms and hands, and knees/feet). @entity2 reports were summarized into a single @entity1 ( @entity1 ). Analyses were stratified for white- and blue-collar workers. RESULTS: Among white-collar workers, ERI and OJ were independently associated with @entity1 . In addition to these additive effects, significant 2-way and 3-way interactions indicated a synergistic effect of job stressors in relation to reported @entity2 . In blue-collar workers, ERI and JDC independently associated with @entity1 , and a significant 3-way interaction was observed showing that the combination of job stressors exceeded an additive effect. CONCLUSION: ERI influences @entity2 symptoms in both occupational groups. OJ was independent significant predictor only among white-collar workers, whereas JDC had additive predictive utility exclusively among blue-collar workers. Simultaneous exposure to multiple job stress factors appeared to synergize @entity2 symptom reporting.

title: Three job stress models and their relationship with XXXX in blue- and white-collar workers.

answer: @entity3


abstract: To date limited data are available to predict the progression to end-stage @entity2 ( @entity2 ) with subsequent @entity1 (non- @entity4 ), need for heart transplantation, or @entity4 ( @entity4 ) in @entity0 with @entity3 ( @entity3 ). We aimed to determine predictors of long-term outcome in @entity0 with @entity3 . A total of 112 @entity0 (median 14.1, IQR 7.8-16.6  years) were followed up for the median of 6.5  years for the development of morbidity and mortality, including arrhythmic and @entity2 -related secondary end points. @entity2 end point included @entity2 or heart transplant, and arrhythmic end point included resuscitated @entity5 , appropriate @entity6 discharge, or @entity4 . Overall, 23 (21  %) @entity0 reached the pre-defined composite primary end point. At 10-year follow-up, the event-free survival rate was 76  %. Thirteen @entity0 (12  %) reached the secondary arrhythmic end point, and 10 @entity0 (9  %) reached the secondary @entity2 end point. In multivariate model, prior @entity5 (r  =  0.658), @entity7 (r  =  0.262), and NSVT (r  =  0.217) were independent predictors of the arrhythmic secondary end point, while @entity2 (r  =  0.440), LV posterior wall thickness (r  =  0.258), LA size (r  =  0.389), and decreased early transmitral flow velocity (r  =  0.202) were all independent predictors of the secondary @entity2 end point. There are differences in the risk factors for @entity4 and for @entity2 in childhood @entity3 . Only prior @entity5 , @entity7 , and NSVT predicted arrhythmic outcome in @entity0 aged <18  years. LA size, LV posterior wall thickness, and decreased early transmitral flow velocity were strong independent predictors of @entity2 -related events.

title: Predictors of Long-Term Outcome in @entity0 with XXXX .

answer: @entity3


abstract: To date limited data are available to predict the progression to end-stage @entity2 ( @entity2 ) with subsequent @entity1 (non- @entity4 ), need for heart transplantation, or @entity4 ( @entity4 ) in @entity0 with @entity3 ( @entity3 ). We aimed to determine predictors of long-term outcome in @entity0 with @entity3 . A total of 112 @entity0 (median 14.1, IQR 7.8-16.6  years) were followed up for the median of 6.5  years for the development of morbidity and mortality, including arrhythmic and @entity2 -related secondary end points. @entity2 end point included @entity2 or heart transplant, and arrhythmic end point included resuscitated @entity5 , appropriate @entity6 discharge, or @entity4 . Overall, 23 (21  %) @entity0 reached the pre-defined composite primary end point. At 10-year follow-up, the event-free survival rate was 76  %. Thirteen @entity0 (12  %) reached the secondary arrhythmic end point, and 10 @entity0 (9  %) reached the secondary @entity2 end point. In multivariate model, prior @entity5 (r  =  0.658), @entity7 (r  =  0.262), and NSVT (r  =  0.217) were independent predictors of the arrhythmic secondary end point, while @entity2 (r  =  0.440), LV posterior wall thickness (r  =  0.258), LA size (r  =  0.389), and decreased early transmitral flow velocity (r  =  0.202) were all independent predictors of the secondary @entity2 end point. There are differences in the risk factors for @entity4 and for @entity2 in childhood @entity3 . Only prior @entity5 , @entity7 , and NSVT predicted arrhythmic outcome in @entity0 aged <18  years. LA size, LV posterior wall thickness, and decreased early transmitral flow velocity were strong independent predictors of @entity2 -related events.

title: Predictors of Long-Term Outcome in XXXX with @entity3 .

answer: @entity0


abstract: BACKGROUND: @entity4 is one of the main risk factors cause @entity2 . It's of great significance to establish an @entity4 animal model that can mimic the characteristics and nature course of @entity0 @entity0 . Therefore, a @entity6 model was induced by high-fat diet to monitor their lipid profile and @entity1 ( @entity1 ) of artery walls and study @entity4 progression. METHODS: Fifty male @entity6 were enrolled in this study. All of these monkeys were aged 7 to 14 years with BMI >30 kg/m2. They were fed with high-fat diet containing 10% of fat for the first 48 weeks. Use ultrasound to measure the @entity1 at bilateral common carotid arteries and their bifurcations and aorta (AO) of the monkeys, and screen out the individuals with thickened @entity1 for the next phase. In the next 48 weeks, some of these monkeys (n = 4) were fed with standard diet containing 3% fat. Meanwhile the other monkeys (n = 5) were fed with high-fat diet for another 48 weeks. Their serum lipid level was monitored and arterial @entity1 was also determined periodically. RESULTS: Serum lipid level of all 50 monkeys elevated after fed with high-fat diet for the first 48 weeks. @entity1 thickening at right common carotid bifurcation and aorta (AO) was thickened in 9 monkeys. Furthermore, 4 of these 9 monkeys were fed with standard diet and other 5 monkeys were fed with high-fat diet in the following 48 weeks. The serum lipid level of the 4 monkeys recovered and their @entity1 at RBIF and AO did not progress. However, the lipid level of other 5 monkeys remained high, and their @entity1 thickening of AO progressed, and plaques and @entity3 focuses were found at the anterior wall of aorta near the bifurcation of common iliac artery. CONCLUSIONS: After high-fat diet induction for 96 weeks, serum lipid levels of @entity6 elevated significantly, which subsequently caused @entity1 thickening and plaques formation. When @entity1 thickening occurred, further @entity5 may be prevented by reducing diet fat content. Our study indicates that @entity5 of high-fat diet induced @entity6 is similar to that of @entity0 in position and progression.

title: Establishment and ultrasound characteristics of XXXX in @entity6 .

answer: @entity4


abstract: BACKGROUND: @entity4 is one of the main risk factors cause @entity2 . It's of great significance to establish an @entity4 animal model that can mimic the characteristics and nature course of @entity0 @entity0 . Therefore, a @entity6 model was induced by high-fat diet to monitor their lipid profile and @entity1 ( @entity1 ) of artery walls and study @entity4 progression. METHODS: Fifty male @entity6 were enrolled in this study. All of these monkeys were aged 7 to 14 years with BMI >30 kg/m2. They were fed with high-fat diet containing 10% of fat for the first 48 weeks. Use ultrasound to measure the @entity1 at bilateral common carotid arteries and their bifurcations and aorta (AO) of the monkeys, and screen out the individuals with thickened @entity1 for the next phase. In the next 48 weeks, some of these monkeys (n = 4) were fed with standard diet containing 3% fat. Meanwhile the other monkeys (n = 5) were fed with high-fat diet for another 48 weeks. Their serum lipid level was monitored and arterial @entity1 was also determined periodically. RESULTS: Serum lipid level of all 50 monkeys elevated after fed with high-fat diet for the first 48 weeks. @entity1 thickening at right common carotid bifurcation and aorta (AO) was thickened in 9 monkeys. Furthermore, 4 of these 9 monkeys were fed with standard diet and other 5 monkeys were fed with high-fat diet in the following 48 weeks. The serum lipid level of the 4 monkeys recovered and their @entity1 at RBIF and AO did not progress. However, the lipid level of other 5 monkeys remained high, and their @entity1 thickening of AO progressed, and plaques and @entity3 focuses were found at the anterior wall of aorta near the bifurcation of common iliac artery. CONCLUSIONS: After high-fat diet induction for 96 weeks, serum lipid levels of @entity6 elevated significantly, which subsequently caused @entity1 thickening and plaques formation. When @entity1 thickening occurred, further @entity5 may be prevented by reducing diet fat content. Our study indicates that @entity5 of high-fat diet induced @entity6 is similar to that of @entity0 in position and progression.

title: Establishment and ultrasound characteristics of @entity4 in XXXX .

answer: @entity6


abstract: The importance of metals in normal and pathologic cardiovascular function has been recognized. Significant derangements in myocardial @entity2 , @entity6 , and @entity12 have been reported in @entity9 . We studied 3 groups of hearts: 1) fifteen specimens obtained from @entity0 who had no @entity3 , 2) nine specimens from @entity0 who had expired from @entity3 , and 3) ten specimens from @entity0 who had expired from @entity10 with @entity8 and severe @entity5 . None of the @entity0 had undergone cardiac surgery. Left ventricular lateral wall @entity6 , @entity2 , @entity12 , and @entity11 contents were measured by atomic absorption spectrometry. The results showed a significant decrease in myocardial @entity6 (Group I 177.06 +/- 32.71; Group II 155.66 +/- 14.79; Group III 149.00 +/- 13.29, p less than 0.05 and p less than 0.01, respectively), and @entity12 contents (Group I 3.22 +/- 0.37; Group II 2.94 +/- 0.22; Group III 2.56 +/- 0.32, p less than 0.02 and p less than 0.001, respectively), and a rise in myocardial @entity2 content (Group I 36.06 +/- 10.72; Group II 43.22 +/- 7.01; Group III 46.30 +/- 4.85, p = not significant, and p less than 0.01, respectively). The myocardial @entity11 content did not change significantly (Group I 26.53 +/- 3.99; Group II 26.00 +/- 4.15; Group III 26.40 +/- 3.53). The myocardial @entity6 / @entity2 ratio was reduced markedly in both groups (Group I 5.328 +/- 1.879; Group II 3.685 +/- 0.735; Group III 3.135 +/- 0.291, p less than 0.001 for both Groups II and III vs Group I). The latter results correlated closely with the myocardial @entity6 / @entity2 ratios reported in experimental models in peri- @entity7 zones. Thus, the myocardium of @entity0 who had expired from @entity3 and @entity13 is jeopardized by @entity1 , with metal contents similar to the border areas in @entity4 .

title: Myocardial metal content in @entity0 who expired from XXXX and @entity10 .

answer: @entity3


abstract: The importance of metals in normal and pathologic cardiovascular function has been recognized. Significant derangements in myocardial @entity2 , @entity6 , and @entity12 have been reported in @entity9 . We studied 3 groups of hearts: 1) fifteen specimens obtained from @entity0 who had no @entity3 , 2) nine specimens from @entity0 who had expired from @entity3 , and 3) ten specimens from @entity0 who had expired from @entity10 with @entity8 and severe @entity5 . None of the @entity0 had undergone cardiac surgery. Left ventricular lateral wall @entity6 , @entity2 , @entity12 , and @entity11 contents were measured by atomic absorption spectrometry. The results showed a significant decrease in myocardial @entity6 (Group I 177.06 +/- 32.71; Group II 155.66 +/- 14.79; Group III 149.00 +/- 13.29, p less than 0.05 and p less than 0.01, respectively), and @entity12 contents (Group I 3.22 +/- 0.37; Group II 2.94 +/- 0.22; Group III 2.56 +/- 0.32, p less than 0.02 and p less than 0.001, respectively), and a rise in myocardial @entity2 content (Group I 36.06 +/- 10.72; Group II 43.22 +/- 7.01; Group III 46.30 +/- 4.85, p = not significant, and p less than 0.01, respectively). The myocardial @entity11 content did not change significantly (Group I 26.53 +/- 3.99; Group II 26.00 +/- 4.15; Group III 26.40 +/- 3.53). The myocardial @entity6 / @entity2 ratio was reduced markedly in both groups (Group I 5.328 +/- 1.879; Group II 3.685 +/- 0.735; Group III 3.135 +/- 0.291, p less than 0.001 for both Groups II and III vs Group I). The latter results correlated closely with the myocardial @entity6 / @entity2 ratios reported in experimental models in peri- @entity7 zones. Thus, the myocardium of @entity0 who had expired from @entity3 and @entity13 is jeopardized by @entity1 , with metal contents similar to the border areas in @entity4 .

title: Myocardial metal content in @entity0 who expired from @entity3 and XXXX .

answer: @entity10


abstract: The importance of metals in normal and pathologic cardiovascular function has been recognized. Significant derangements in myocardial @entity2 , @entity6 , and @entity12 have been reported in @entity9 . We studied 3 groups of hearts: 1) fifteen specimens obtained from @entity0 who had no @entity3 , 2) nine specimens from @entity0 who had expired from @entity3 , and 3) ten specimens from @entity0 who had expired from @entity10 with @entity8 and severe @entity5 . None of the @entity0 had undergone cardiac surgery. Left ventricular lateral wall @entity6 , @entity2 , @entity12 , and @entity11 contents were measured by atomic absorption spectrometry. The results showed a significant decrease in myocardial @entity6 (Group I 177.06 +/- 32.71; Group II 155.66 +/- 14.79; Group III 149.00 +/- 13.29, p less than 0.05 and p less than 0.01, respectively), and @entity12 contents (Group I 3.22 +/- 0.37; Group II 2.94 +/- 0.22; Group III 2.56 +/- 0.32, p less than 0.02 and p less than 0.001, respectively), and a rise in myocardial @entity2 content (Group I 36.06 +/- 10.72; Group II 43.22 +/- 7.01; Group III 46.30 +/- 4.85, p = not significant, and p less than 0.01, respectively). The myocardial @entity11 content did not change significantly (Group I 26.53 +/- 3.99; Group II 26.00 +/- 4.15; Group III 26.40 +/- 3.53). The myocardial @entity6 / @entity2 ratio was reduced markedly in both groups (Group I 5.328 +/- 1.879; Group II 3.685 +/- 0.735; Group III 3.135 +/- 0.291, p less than 0.001 for both Groups II and III vs Group I). The latter results correlated closely with the myocardial @entity6 / @entity2 ratios reported in experimental models in peri- @entity7 zones. Thus, the myocardium of @entity0 who had expired from @entity3 and @entity13 is jeopardized by @entity1 , with metal contents similar to the border areas in @entity4 .

title: Myocardial metal content in XXXX who expired from @entity3 and @entity10 .

answer: @entity0


abstract: @entity2 is a devastating injury that results in a number of pathological alterations in almost every system in the body. @entity4 , muscle wasting, @entity3 immunity, and @entity1 are all clinical features of burns. Failure to address each of these specific pathological alterations can lead to increased mortality. Nutrition supplementation has been recommended as a therapeutic tool to help attenuate the @entity4 and devastating catabolism evident following burn. Despite the wide consensus on the need of nutrition supplementation in burn @entity0 , controversy exists with regard to the type and amount of nutrition recommended. Nutrition alone is also not enough in these @entity0 to halt and reverse some of the damage done by the catabolic pathways activated following severe @entity2 . This has led to the use of anabolic pharmacologic agents in conjunction with nutrition to help improve @entity0 outcome following @entity2 . In this review, we examine the relevant literature on nutrition after @entity2 and its contribution to the attenuation of the postburn @entity4 response, @entity1 , and suppressed immunological responses. We also review the commonly used anabolic agents clinically in the care of burn @entity0 . Finally, we provide nutrition and pharmacological recommendations gained from prospective trials, retrospective analyses, and expert opinions based on our practice at the Ross Tilley Burn Center in Toronto, Canada.

title: Nutrition and anabolic pharmacotherapies in the care of burn XXXX .

answer: @entity0


abstract: PURPOSE: Compare conspicuity of @entity2 ( @entity2 ) to benign @entity1 on unenhanced (bCT), contrast-enhanced dedicated breast CT (CEbCT) and mammography ( @entity3 ). METHODS AND MATERIALS: The institutional review board approved this HIPAA-compliant study. 42 @entity0 with Breast Imaging Reporting and Data System 4 or 5 category micro- @entity1 had breast CT before biopsy. Three subjects with invasive disease at surgery were excluded. Two breast radiologists independently compared lesion conspicuity scores (CS) for CEbCT, to bCT and @entity3 . Enhancement was measured in Hounsfield units (HU). Mean CS  standard deviations are shown. Receiver operating characteristic analysis (ROC) measured radiologists' discrimination performance by comparing CS to enhancement alone. Statistical measurements were made using ANOVA F-test, Wilcoxon rank-sum test and robust linear regression analyses. RESULTS: 39 lesions (17 @entity2 , 22 benign) were analyzed. @entity2 (8.5  0.9, n=17) was more conspicuous than benign micro- @entity1 (3.6  2.9, n=22; p<0.0001) on CEbCT. @entity2 was equally conspicuous on CEbCT and @entity3 (8.5  0.9, 8.7  0.8, n=17; p=0.85) and more conspicuous when compared to bCT (5.3  2.6, n=17; p<0.001). All @entity2 enhanced; mean enhancement (90HU  53HU, n=17) was higher compared to benign lesions (33  30HU, n=22) (p<0.0001). ROC analysis of the radiologists' CS showed high discrimination performance (AUC=0.94) compared to enhancement alone (AUC=0.85) (p<0.026). CONCLUSION: @entity2 is more conspicuous than benign micro- @entity1 on CEbCT. @entity2 visualization on CEbCT is equal to mammography but improved compared to bCT. Radiologists' discrimination performance using CEBCT is significantly higher than enhancement values alone. CEbCT may have an advantage over mammography by reducing false positive examinations when @entity1 are analyzed.

title: Differentiation of ductal carcinoma in-situ from benign micro- XXXX by dedicated breast computed tomography.

answer: @entity1


abstract: OBJECTIVES: To provide an epidemiological framework of symptoms related to Foreign Body (FB) injuries due to Button Battery (BB). METHODS: Data on BB ingestion/inhalation have been obtained from the ButtonBatteryDB. The ButtonBatteryDB is a database collecting information on @entity1 in @entity0 (0-18 years of age). Data on 348 BB injures have been derived from the Registry of Foreign Body Injuries "Susy Safe" (269 cases) and from published scientific literature reporting case reports of @entity1 (79 cases). RESULTS: Most of injured @entity0 were male and BBs were found more often in the mouth/esophagus/stomach (ICD935) and in the nose (ICD932). Analyzing symptoms related to BB located in the esophagus/mouth/stomach, we found that @entity0 had higher probability of experiencing @entity4 (30.19%, 95% C.I. 17.83-42.55), @entity3 and cough (26.42%, 95% C.I. 14.55-38.28), compared to the other symptoms. Referring to the probability that symptoms occurred simultaneously, @entity3 and cough are more likely (3.72%, 95% C.I. 1.0-6-43) to jointly showing up in @entity0 with BB in mouth/esophagus/stomach (ICD935), followed by @entity3 and @entity4 (2.66%, 95% C.I. 0.36-4.96) and by @entity3 and @entity2 /crying, @entity3 and drooling, @entity4 and @entity2 /crying (2.13% C.I. 0.00-4.19, 95% C.I.) CONCLUSIONS: These findings provide new insight in clinical presentation of @entity1 : the identification of unique patterns of symptoms related to @entity1 is useful to perform an early diagnosis (and to guarantee a prompt medical reaction), also when the injury is un-witnessed.

title: Symptoms associated with button batteries injuries in XXXX : An epidemiological review.

answer: @entity0