abstract: BACKGROUND: The Work Limitations Questionnaire-25 (WLQ-25) and the Work Instability Scale for @entity3 (RA-WIS) have been used to measure at-work disability related to @entity1 . However, a recent systematic review has shown that important psychometric properties still needed to be evaluated. OBJECTIVE: The purpose of this study was to establish the validity and responsiveness of the WLQ-25 and RA-WIS in @entity0 with chronic work-related @entity4 . DESIGN: Two-hundred six @entity0 with chronic @entity4 who attended a specialty clinic operated by the Workplace Safety _ Insurance Board of Ontario were evaluated at their initial visit and 6 months later. METHODS: Questionnaires completed at each evaluation were: the WLQ-25, the RA-WIS, the QuickDASH, the @entity2 subscale of the Shoulder @entity2 and Disability Questionnaire, and the @entity6 Grade Questionnaire. At the 6-month evaluation, @entity0 completed a global rating of change question. Known-group and construct convergent validity were assessed using analysis of variance and Pearson correlations, and standardized response means (SRMs) were used to assess responsiveness. @entity5 ( @entity5 ) also were determined. RESULTS: The WLQ-25 and RA-WIS had low to moderate correlations with @entity2 and disability scales (.28<r<.62) and discriminated among different functional categories (P<.001). For improved @entity0 , the WLQ-25 (SRM=0.65 for summed score, SRM=0.63 for index score) and the RA-WIS (SRM=0.66) demonstrated moderate responsiveness. The CID for improvement was estimated to be 13/100 points for the WLQ-25 summed score, 5/28.6 points for the WLQ-25 index score, and 4/23 points for the RA-WIS. LIMITATIONS: The external criterion of change was specific to change in @entity7 and not to change in work ability or productivity. CONCLUSIONS: The WLQ-25 and RA-WIS provide different information from that provided by @entity2 and disability measures. They discriminate among functional outcome subgroups and detect improvement over time in @entity0 with chronic work-related @entity4 .

title: Validity and responsiveness of presenteeism scales in chronic work-related XXXX .

answer: @entity4


abstract: @entity7 is characterized by @entity7 . We describe a @entity0 with a huge caudate lobe of the liver due to @entity7 . A 49-year-old @entity0 was referred to Nippon Medical School Hospital to receive treatment for enlarged @entity6 . She had been followed up for @entity8 with @entity3 for 7 years and had undergone surgery for @entity1 5 years earlier. Upper gastrointestinal endoscopy revealed @entity6 without esophageal varices. Abdominal computed tomography revealed obstructions and scars of the right, middle, and left hepatic veins. The caudate lobe was enlarged, and the portal vein was displaced ventrally, without @entity4 . The drainage vein of the caudate lobe, the short hepatic vein on the left side of the inferior vena cava, was dilated. The portal vein and drainage vein of segment 6 were visualized and showed no @entity2 . Venography revealed no obstruction of the inferior vena cava. @entity7 with @entity6 was diagnosed on the basis of these findings. We performed balloon-occluded retrograde transvenous obliteration and partial @entity5 to treat the @entity6 . The posttreatment course was uneventful, and the @entity0 was discharged 8 days after embolization. The @entity6 shrank.

title: Huge caudate lobe of the liver due to XXXX .

answer: @entity7


abstract: INTRODUCTION: Osseointegrated bone-anchored hearing systems (BAHSs) are a useful tool in auditory rehabilitation for single-sided @entity3 and conductive/mixed @entity1 . They rely on adequate osseointegration of @entity2 implants, which can be limited by @entity4 . This study examines adult computed tomographic (CT) temporal bone normative data for @entity4 in the areas commonly recommended for BAHS insertion and identifies hazards that may compromise the osseointegration process. METHODS: Prospective analysis of 100 consecutive adult helical CT scans. Calvarial thickness was measured in axial and coronal planes 5.5 cm posterior to the superior external auditory canal at 6 vertical points ( @entity5 cm). Other parameters measured include temporal bone pneumatization and the presence of suture lines, bone marrow, and vascular structures. RESULTS: A total of 195 temporal bones were examined in 100 @entity0 . Mean @entity0 age was 60.9 years, of whom 54.4% were @entity0 and 45.6% were @entity0 . Mean @entity4 was greatest at +1 cm above the @entity5 level (6.3 mm) and thinnest at +4 cm (5.1 mm). Of temporal bones, 55% had at least 1 site thinner than 4 mm and 21% had at least 1 site thinner than 3 mm. Air cells and suture lines were more likely to be encountered within 2 cm above the @entity5 level, and marrow space is more likely to be encountered 3 to 4 cm above the @entity5 level. DISCUSSION: Selecting a position 3 to 4 cm above the level of the @entity5 is more likely to result in dural exposure for a 3-mm BAHS abutment, especially in @entity0 . Selecting a position near the level of the @entity5 provides thicker bone, but the surgeon is more likely to encounter suture line or enter mastoid air cells. Preoperative CT imaging may be a useful tool in evaluating @entity4 and hazards when planning BAHS insertion in the adult population.

title: Computed tomographic analysis of outer XXXX for osseointegrated bone-anchored hearing system insertion.

answer: @entity4


abstract: @entity11 ) is a unique oncogenic virus with distinctive biological properties. @entity11 is the only virus causing a naturally occurring @entity1 ( @entity7 , OPA) and possessing a major structural protein that functions as a dominant oncoprotein. @entity1 is the major cause of @entity5 among @entity2 @entity0 . OPA can be an extremely useful animal model in order to identify the cells originating @entity10 and to study the early events of @entity4 . In this study, we demonstrated that @entity10 in @entity9 originates from @entity6 and transformation of proliferating type 2 pneumocytes (termed here lung alveolar proliferating cells, LAPCs). We excluded that OPA originates from a bronchioalveolar stem cell, or from mature post-mitotic type 2 pneumocytes or from either proliferating or non-proliferating Clara cells. We show that young animals possess abundant LAPCs and are highly susceptible to @entity11 @entity6 and transformation. On the contrary, healthy adult @entity9 , which are normally resistant to experimental OPA induction, exhibit a relatively low number of LAPCs and are resistant to @entity11 @entity6 of the respiratory epithelium. Importantly, induction of @entity8 increased dramatically the number of LAPCs in adult @entity9 and rendered these animals fully susceptible to @entity11 @entity6 and transformation. Furthermore, we show that @entity11 preferentially infects actively dividing cell in vitro. Overall, our study provides unique insights into pulmonary biology and @entity4 and suggests that @entity11 and its host have reached an evolutionary equilibrium in which productive @entity6 (and transformation) can occur only in cells that are scarce for most of the lifespan of the @entity9 . Our data also indicate that, at least in this model, @entity3 can predispose to @entity6 and @entity2 .

title: XXXX originates from retrovirus @entity6 of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair.

answer: @entity10


abstract: @entity11 ) is a unique oncogenic virus with distinctive biological properties. @entity11 is the only virus causing a naturally occurring @entity1 ( @entity7 , OPA) and possessing a major structural protein that functions as a dominant oncoprotein. @entity1 is the major cause of @entity5 among @entity2 @entity0 . OPA can be an extremely useful animal model in order to identify the cells originating @entity10 and to study the early events of @entity4 . In this study, we demonstrated that @entity10 in @entity9 originates from @entity6 and transformation of proliferating type 2 pneumocytes (termed here lung alveolar proliferating cells, LAPCs). We excluded that OPA originates from a bronchioalveolar stem cell, or from mature post-mitotic type 2 pneumocytes or from either proliferating or non-proliferating Clara cells. We show that young animals possess abundant LAPCs and are highly susceptible to @entity11 @entity6 and transformation. On the contrary, healthy adult @entity9 , which are normally resistant to experimental OPA induction, exhibit a relatively low number of LAPCs and are resistant to @entity11 @entity6 of the respiratory epithelium. Importantly, induction of @entity8 increased dramatically the number of LAPCs in adult @entity9 and rendered these animals fully susceptible to @entity11 @entity6 and transformation. Furthermore, we show that @entity11 preferentially infects actively dividing cell in vitro. Overall, our study provides unique insights into pulmonary biology and @entity4 and suggests that @entity11 and its host have reached an evolutionary equilibrium in which productive @entity6 (and transformation) can occur only in cells that are scarce for most of the lifespan of the @entity9 . Our data also indicate that, at least in this model, @entity3 can predispose to @entity6 and @entity2 .

title: @entity10 originates from retrovirus XXXX of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair.

answer: @entity6


abstract: @entity2 ( @entity2 ) is the most common and aggressive primary @entity3 with very poor @entity0 median survival. To identify a microRNA (miRNA) expression signature that can predict @entity2 @entity0 survival, we analyzed the miRNA expression data of @entity2 @entity0 (n=222) derived from The @entity1 (TCGA) dataset. We divided the @entity0 randomly into training and testing sets with equal number in each group. We identified 10 significant miRNAs using Cox regression analysis on the training set and formulated a risk score based on the expression signature of these miRNAs that segregated the @entity0 into high and low risk groups with significantly different survival times (hazard ratio [HR]=2.4; 95% CI=1.4-3.8; p<0.0001). Of these 10 miRNAs, 7 were found to be risky miRNAs and 3 were found to be protective. This signature was independently validated in the testing set (HR=1.7; 95% CI=1.1-2.8; p=0.002). @entity2 @entity0 with high risk scores had overall poor survival compared to the @entity0 with low risk scores. Overall survival among the entire @entity0 set was 35.0% at 2 years, 21.5% at 3 years, 18.5% at 4 years and 11.8% at 5 years in the low risk group, versus 11.0%, 5.5%, 0.0 and 0.0% respectively in the high risk group (HR=2.0; 95% CI=1.4-2.8; p<0.0001). Cox multivariate analysis with @entity0 age as a covariate on the entire @entity0 set identified risk score based on the 10 miRNA expression signature to be an independent predictor of @entity0 survival (HR=1.120; 95% CI=1.04-1.20; p=0.003). Thus we have identified a miRNA expression signature that can predict @entity2 @entity0 survival. These findings may have implications in the understanding of gliomagenesis, development of targeted therapy and selection of high risk @entity1 @entity0 for adjuvant therapy.

title: A ten-microRNA expression signature predicts survival in XXXX .

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) is one of the most common @entity1 with gender differences in prevalence and clinical presentation. This study aimed to examine whether such gender differences are correlated with cumulative healthcare utilization in Taiwan. METHODS: The National Health Insurance Research Database supplied claim records of one million individuals from 1996 to 2007. Selected cases included @entity0 aged >16 years. Certified rheumatologists diagnosed the @entity0 in three or more visits and gave prescriptions for @entity2 . Multivariate adjusted logistic regression analyses were used to calculate the influence of gender on cumulative healthcare utilization associated with @entity2 . RESULTS: The study included 228 @entity0 and 636 @entity0 . After adjustment for potential confounding factors, @entity0 had more cumulative outpatient visits associated with @entity2 (odds ratio, 1.59; 95% confidence interval, 1.13 -2.23; p = 0.008). @entity0 also exhibited a trend for higher frequency of @entity2 -related hospitalization (p = 0.054). CONCLUSION: @entity0 are more likely to have high cumulative @entity2 -associated healthcare utilization than @entity0 . Further investigation of the causal factors is warranted.

title: Gender differences in XXXX -associated cumulative healthcare utilization: a population-based cohort study.

answer: @entity2


abstract: Obesity can adversely affect @entity0 health, including fertility. While @entity1 can disturb the hormonal profile of the female organism and is associated with fertility loss, little is known about what effect male @entity1 has on fertility. The present study analysed sperm samples of 153 donors. The @entity0 were selected from couples attending an @entity2 clinic, who had tried for 12 months or more to achieve pregnancy without success. The age of the @entity0 under investigation was recorded, and their body mass index (BMI) was calculated. All semen samples were assessed for volume, concentration, motility and morphology. Sperm chromatin integrity was measured by sperm chromatin structure assay. Quality of sperm chromatin condensation was assessed by @entity3 , @entity5 and @entity4 staining. We can conclude that the impact of elevated BMI on the parameters investigated (basic semen parameters, chromatin integrity and chromatin condensation) was not proven in this study. On the other hand, ejaculate quality appeared to be affected by ageing. The impact was reflected by chromatin integrity, which is a factor that can substantially affect fertility in @entity0 , rather than by basic sperm parameters.

title: Male XXXX and age in relationship to semen parameters and sperm chromatin integrity.

answer: @entity1


abstract: We compared the tolerability and efficacy of @entity2 ( @entity4 ) versus @entity2 (MPS) among renal transplant recipients on @entity3 -based immunosuppression. The 105 @entity0 who underwent kidney transplantation between January 2002 and March 2008 and were treated with @entity1 , @entity3 , and a @entity5 compound were enrolled in the study. From @entity0 files we collected on demographics data, donors, immunosuppressive drug doses, biochemical and hematologic parameters, gastrointestinal and hematologic side effects, and kidney function. Fifty-six @entity0 were prescribed @entity4 and 49 of them were taking MPS. Demographic parameters and pretransplantation dialysis duration were similar between the 2 groups. After the third month, the MPS dose was higher than that of @entity4 . There were no clinically important differences between the 2 groups, regarding other immunosuppressive drug doses. Gastrointestinal side effects were similar: 42.4% in the @entity4 versus 44.8% in the MPS group (P = .846). Six @entity0 in the @entity4 group and 1 @entity0 in the MPS group underwent a switch of the @entity5 therapy due to severe gastrointestinal side effects (P = .183). Biopsy-proven acute rejection was reported in 6 @entity0 on @entity4 and 7 @entity0 on MPS therapy (P = .768). The log-rank test evaluating a 50% reduction in glomerular filtration rate (GFR) showed no significant difference between the 2 groups (P = .719). No deaths were recorded during the study period; there was only 1 graft loss, which occurred in the @entity4 group. We did not observe a significant difference in tolerability and efficacy between the 2 widely used @entity5 derivatives. Economic considerations can be an important factor when choosing the drug.

title: A comparison of @entity2 with @entity2 in renal transplant recipients on XXXX -based treatment.

answer: @entity3


abstract: We compared the tolerability and efficacy of @entity2 ( @entity4 ) versus @entity2 (MPS) among renal transplant recipients on @entity3 -based immunosuppression. The 105 @entity0 who underwent kidney transplantation between January 2002 and March 2008 and were treated with @entity1 , @entity3 , and a @entity5 compound were enrolled in the study. From @entity0 files we collected on demographics data, donors, immunosuppressive drug doses, biochemical and hematologic parameters, gastrointestinal and hematologic side effects, and kidney function. Fifty-six @entity0 were prescribed @entity4 and 49 of them were taking MPS. Demographic parameters and pretransplantation dialysis duration were similar between the 2 groups. After the third month, the MPS dose was higher than that of @entity4 . There were no clinically important differences between the 2 groups, regarding other immunosuppressive drug doses. Gastrointestinal side effects were similar: 42.4% in the @entity4 versus 44.8% in the MPS group (P = .846). Six @entity0 in the @entity4 group and 1 @entity0 in the MPS group underwent a switch of the @entity5 therapy due to severe gastrointestinal side effects (P = .183). Biopsy-proven acute rejection was reported in 6 @entity0 on @entity4 and 7 @entity0 on MPS therapy (P = .768). The log-rank test evaluating a 50% reduction in glomerular filtration rate (GFR) showed no significant difference between the 2 groups (P = .719). No deaths were recorded during the study period; there was only 1 graft loss, which occurred in the @entity4 group. We did not observe a significant difference in tolerability and efficacy between the 2 widely used @entity5 derivatives. Economic considerations can be an important factor when choosing the drug.

title: A comparison of XXXX with @entity2 in renal transplant recipients on @entity3 -based treatment.

answer: @entity2


abstract: We compared the tolerability and efficacy of @entity2 ( @entity4 ) versus @entity2 (MPS) among renal transplant recipients on @entity3 -based immunosuppression. The 105 @entity0 who underwent kidney transplantation between January 2002 and March 2008 and were treated with @entity1 , @entity3 , and a @entity5 compound were enrolled in the study. From @entity0 files we collected on demographics data, donors, immunosuppressive drug doses, biochemical and hematologic parameters, gastrointestinal and hematologic side effects, and kidney function. Fifty-six @entity0 were prescribed @entity4 and 49 of them were taking MPS. Demographic parameters and pretransplantation dialysis duration were similar between the 2 groups. After the third month, the MPS dose was higher than that of @entity4 . There were no clinically important differences between the 2 groups, regarding other immunosuppressive drug doses. Gastrointestinal side effects were similar: 42.4% in the @entity4 versus 44.8% in the MPS group (P = .846). Six @entity0 in the @entity4 group and 1 @entity0 in the MPS group underwent a switch of the @entity5 therapy due to severe gastrointestinal side effects (P = .183). Biopsy-proven acute rejection was reported in 6 @entity0 on @entity4 and 7 @entity0 on MPS therapy (P = .768). The log-rank test evaluating a 50% reduction in glomerular filtration rate (GFR) showed no significant difference between the 2 groups (P = .719). No deaths were recorded during the study period; there was only 1 graft loss, which occurred in the @entity4 group. We did not observe a significant difference in tolerability and efficacy between the 2 widely used @entity5 derivatives. Economic considerations can be an important factor when choosing the drug.

title: A comparison of @entity2 with XXXX in renal transplant recipients on @entity3 -based treatment.

answer: @entity2


abstract: OBJECTIVE: Between 25% and 30% of @entity0 and adolescents experience @entity1 . These disorders are complex phenotypes that are regulated by many genes, the environment, and gene-environment interactions. The objective of this study was to evaluate the contribution of genetic and environmental factors to @entity2 in early childhood and to contribute to the knowledge on appropriate therapeutic approaches, using a twin design. @entity0 AND METHODS: Data on sleeping behavior were collected from 314 18-month-old twin pairs (127 monozygotic and 187 dizygotic)using a parent-rated questionnaire. We used structural equation modeling to estimate genetic and environmental variance components for different @entity2 (cosleeping, sleep duration, and night awakenings). RESULTS: Shared environment explained almost all (98.3%) of the total variance in cosleeping. Sleep duration was substantially influenced by shared environmental factors (64.1% nocturnal sleep and 61.2% diurnal sleep), with a moderate contribution of additive genetic effects (30.8% and 36.3% for nocturnal and diurnal sleep, respectively). For nocturnal waking episodes, we found a shared environmental contribution of 63.2% and a heritability estimate of 35.3%. CONCLUSIONS: Most @entity1 during early childhood are explained by common shared environmental factors, and behavioral interventions adopted by parents and focused on modifying @entity2 could contribute to solving @entity1 in this age group. However, the influence of genetic factors should not be underestimated, and research in this area could clarify the physiologic architecture of sleeping and contribute to selecting appropriate personalized therapeutic approaches.

title: Genetic and environmental factors shape XXXX sleep patterns: a study of 18-month-old twins.

answer: @entity0


abstract: PURPOSE: @entity5 inhibitors, such as @entity6 , are in clinical development in combination with cytotoxic agents for the treatment of solid @entity0 , including @entity3 . To maximize the likelihood of their clinical success, it is essential to optimize drug scheduling as well as pharmacodynamic biomarkers in preclinical models. EXPERIMENTAL DESIGN: We tested multiple schedules of administration of @entity1 and @entity6 on the survival of @entity3 cells. Potential pharmacodynamic biomarkers including pChk1, pChk2, pHistone H3, and @entity2 were evaluated in vitro, followed by assessment of promising candidate biomarkers in vivo. We then went on to determine the contributions of @entity4 and DNA damage to the mechanism(s) of induction of the identified biomarker, pS345 @entity5 . RESULTS: @entity6 given during and after or after @entity1 administration produced maximum chemosensitization. In vivo, @entity6 significantly inhibited the growth of @entity3 xenografts in response to @entity1 . Of the biomarkers assessed, pS345 @entity5 was most consistently increased in response to @entity1 and @entity6 in @entity0 and normal tissues (hair follicles). pS345 @entity5 induction in response to @entity1 and @entity6 occurred in the presence of @entity4 inhibition and in association with elevated yH2AX, suggesting that DNA damage is an underlying mechanism. CONCLUSIONS: @entity6 sensitizes @entity3 to @entity1 in association with induction of pS345 @entity5 . Together these data support the clinical investigation of @entity6 with @entity1 in @entity3 under a dosing schedule in which @entity1 is administered concurrent with or before @entity6 and in conjunction with skin biopsies to measure pS345 @entity5 .

title: Assessment of XXXX phosphorylation as a pharmacodynamic biomarker of @entity5 inhibition.

answer: @entity5


abstract: PURPOSE: @entity5 inhibitors, such as @entity6 , are in clinical development in combination with cytotoxic agents for the treatment of solid @entity0 , including @entity3 . To maximize the likelihood of their clinical success, it is essential to optimize drug scheduling as well as pharmacodynamic biomarkers in preclinical models. EXPERIMENTAL DESIGN: We tested multiple schedules of administration of @entity1 and @entity6 on the survival of @entity3 cells. Potential pharmacodynamic biomarkers including pChk1, pChk2, pHistone H3, and @entity2 were evaluated in vitro, followed by assessment of promising candidate biomarkers in vivo. We then went on to determine the contributions of @entity4 and DNA damage to the mechanism(s) of induction of the identified biomarker, pS345 @entity5 . RESULTS: @entity6 given during and after or after @entity1 administration produced maximum chemosensitization. In vivo, @entity6 significantly inhibited the growth of @entity3 xenografts in response to @entity1 . Of the biomarkers assessed, pS345 @entity5 was most consistently increased in response to @entity1 and @entity6 in @entity0 and normal tissues (hair follicles). pS345 @entity5 induction in response to @entity1 and @entity6 occurred in the presence of @entity4 inhibition and in association with elevated yH2AX, suggesting that DNA damage is an underlying mechanism. CONCLUSIONS: @entity6 sensitizes @entity3 to @entity1 in association with induction of pS345 @entity5 . Together these data support the clinical investigation of @entity6 with @entity1 in @entity3 under a dosing schedule in which @entity1 is administered concurrent with or before @entity6 and in conjunction with skin biopsies to measure pS345 @entity5 .

title: Assessment of @entity5 phosphorylation as a pharmacodynamic biomarker of XXXX inhibition.

answer: @entity5


abstract: OBJECTIVES: We evaluated the results of the Turkish arm of the GOOD survey which investigated the cardiometabolic risk profile and the control of blood pressure (BP) of adult @entity3 outpatients in 12 countries across Europe. STUDY DESIGN: A total of 218 @entity3 @entity0 (139 females, 79 males; mean age 57.2  10.9 years) from @entity5 were included in this pan-European survey. Blood pressure control (defined as BP <140/90 mmHg for nondiabetics and <130/80 mmHg for @entity1 ) and cardiometabolic risk factors such as @entity1 , @entity4 , @entity2 , sedentary lifestyle, and @entity6 were evaluated in accordance with the 2003 ESH/ESC guidelines on management of @entity3 . RESULTS: Control of BP was achieved in only 21.6% of the @entity0 diagnosed with @entity3 for a mean duration of 7.7  5.4 years. The mean systolic and diastolic BPs were 144  21 mmHg and 88  14 mmHg, respectively. The most frequent concomitant disease was @entity1 (66 @entity0 , 30.3%). @entity0 with @entity1 had a higher prevalence of @entity4 compared to nondiabetics (78.8% vs. 48%, p<0.01). The absence of BP control was more pronounced among @entity1 than in nondiabetics for systolic (77.3% vs. 63.8%) and diastolic (84.9% vs. 57.2%) pressures. Nearly half of the @entity3 @entity0 had @entity6 , but only 35.8% of them were treated with lipid lowering drugs. CONCLUSION: Despite appropriate treatment, poor BP control in Turkish @entity3 @entity0 was associated with @entity4 , @entity1 , and undertreatment of @entity6 . Therefore, more effective measures must be taken in the management of cardiovascular risk factors to improve BP control.

title: Global cardiometabolic risk profile in @entity0 with XXXX : results from the Turkish arm of the pan-European GOOD survey.

answer: @entity3


abstract: OBJECTIVES: We evaluated the results of the Turkish arm of the GOOD survey which investigated the cardiometabolic risk profile and the control of blood pressure (BP) of adult @entity3 outpatients in 12 countries across Europe. STUDY DESIGN: A total of 218 @entity3 @entity0 (139 females, 79 males; mean age 57.2  10.9 years) from @entity5 were included in this pan-European survey. Blood pressure control (defined as BP <140/90 mmHg for nondiabetics and <130/80 mmHg for @entity1 ) and cardiometabolic risk factors such as @entity1 , @entity4 , @entity2 , sedentary lifestyle, and @entity6 were evaluated in accordance with the 2003 ESH/ESC guidelines on management of @entity3 . RESULTS: Control of BP was achieved in only 21.6% of the @entity0 diagnosed with @entity3 for a mean duration of 7.7  5.4 years. The mean systolic and diastolic BPs were 144  21 mmHg and 88  14 mmHg, respectively. The most frequent concomitant disease was @entity1 (66 @entity0 , 30.3%). @entity0 with @entity1 had a higher prevalence of @entity4 compared to nondiabetics (78.8% vs. 48%, p<0.01). The absence of BP control was more pronounced among @entity1 than in nondiabetics for systolic (77.3% vs. 63.8%) and diastolic (84.9% vs. 57.2%) pressures. Nearly half of the @entity3 @entity0 had @entity6 , but only 35.8% of them were treated with lipid lowering drugs. CONCLUSION: Despite appropriate treatment, poor BP control in Turkish @entity3 @entity0 was associated with @entity4 , @entity1 , and undertreatment of @entity6 . Therefore, more effective measures must be taken in the management of cardiovascular risk factors to improve BP control.

title: Global cardiometabolic risk profile in XXXX with @entity3 : results from the Turkish arm of the pan-European GOOD survey.

answer: @entity0


abstract: BACKGROUND: Approximately 4 to 34 percent of @entity0 born with neonatal @entity1 do not recover spontaneously and require surgery. Despite the increasing availability of microsurgical nerve repair, the authors hypothesize that this condition remains undertreated and that uninsured @entity0 and @entity0 with public insurance are less likely to receive treatment than those with private insurance. METHODS: The authors used a national sample of inpatient hospital discharge data from the Healthcare Cost and Utilization Kids Inpatient Databases for the years 1997, 2000, 2003, and 2006. Relevant discharges were identified using the International Classification of Diseases, Ninth Revision diagnosis code 767.6 for neonatal @entity1 and procedure codes relating to nerve surgery. Weighted frequencies were calculated to generate national estimates for neonatal @entity1 births and nerve surgery procedures for these @entity0 . RESULTS: A total of 21,758 births with neonatal @entity1 and 721 admissions for nerve surgery were identified. Over time, utilization of nerve surgery procedures has generally increased (1.1 percent in 1997 to 3.2 percent in 2006). Treatment with nerve surgery varied significantly according to insurance status-3.8 percent among private insurance discharges, 2.9 percent among Medicaid insurance discharges, and 0.7 percent among self-pay/uninsured records (p < 0.001). The mean age among nerve surgery @entity0 was 235    75 days, and the mean total charges associated with microsurgical intervention was  24,534     30,460. CONCLUSIONS: Over the past decade, approximately 3.3 percent of neonatal @entity1 births have undergone some form of primary microsurgical nerve surgical intervention, which may reflect underutilization of these procedures and limited access to care. Insurance status plays a significant role in the use of nerve surgery procedures, as neonates without private insurance were less likely to receive nerve surgery procedures than those with private insurance.

title: A national study to evaluate trends in the utilization of nerve reconstruction for treatment of neonatal XXXX [outcomes article].

answer: @entity1


abstract: Allografts of the forearm are still uncommon in the field of composite tissue allograft transplantation. In November 2007, a right-hand allograft and a left-hand/full-length forearm allograft were transplanted in a 30-year-old @entity0 who lost both hands and the vision in his left eye due to an explosion. The @entity0 underwent alemtuzumab and @entity3 induction therapy. @entity7 , @entity5 , and low doses of @entity4 were given to prevent rejection. The allografts were rejected 3 times, but these episodes were controlled successfully. The immunosuppressive regimen was switched from @entity7 to @entity9 because of increased serum @entity6 . The left allograft showed a @entity8 due to muscle @entity2 that was conjectured to be associated with a perioperative @entity1 and permitted only a Moberg-type key pinch. In contrast, an excellent grade of function was observed in the right allograft. The Disabilities of the Shoulder, Arm, and Hand score improved from 70.83 to 36.6 and intrinsic musculature returned to both allografts. The @entity0 was able to work 2 years after transplantation. This is the first report of an @entity1 related to the successful allotransplantation of a composite tissue.

title: Perioperative XXXX and fibrotic degeneration of muscle in a forearm allograft: functional follow-up at 32 months post transplantation.

answer: @entity1


abstract: BACKGROUND: @entity2 is a disease caused by the oral ingestion of eggs from the @entity0 parasitic worm @entity3 . Although drugs are available they are controversial because of the side effects and poor efficiency. An expressed sequence tag (EST) library is a method used to describe the gene expression profile and sequence of mRNA from a specific organism and stage. Such information can be used in order to find new targets for the development of drugs and to get a better understanding of the parasite biology. METHODS AND FINDINGS: Here an EST library consisting of 5760 sequences from the @entity1 cysticerca stage has been constructed. In the library 1650 unique sequences were found and of these, 845 sequences (52%) were novel to @entity3 and not identified within other EST libraries. Furthermore, 918 sequences (55%) were of unknown function. Amongst the 25 most frequently expressed sequences 6 had no relevant similarity to other sequences found in the Genbank NR DNA database. A prediction of putative signal peptides was also performed and 4 among the 25 were found to be predicted with a signal peptide. Proposed vaccine and diagnostic targets T24, Tsol18/HP6 and Tso31d could also be identified among the 25 most frequently expressed. CONCLUSIONS: An EST library has been produced from @entity1 cysticerca and analyzed. More than half of the different ESTs sequenced contained a sequence with no suggested function and 845 novel EST sequences have been identified. The library increases the knowledge about what genes are expressed and to what level. It can also be used to study different areas of research such as drug and diagnostic development together with parasite fitness via e.g. immune modulation.

title: Analyses of an expressed sequence tag library from XXXX , Cysticerca.

answer: @entity3


abstract: OBJECTIVE: To describe a @entity0 with @entity11 and mesencephalic presentation of a @entity15 and @entity7 antibody-associated paraneoplastic @entity2 . DESIGN: Case report. SETTING: The Colorado Neurological Institute @entity9 Center in Englewood, Colorado, and the Mayo Clinic in Rochester, Minnesota. @entity0 : A 55-year-old @entity0 with a paraneoplastic @entity2 characterized by @entity10 movement @entity5 , @entity12 , and a @entity14 in the setting of @entity6 . INTERVENTION: Immunotherapy for paraneoplastic @entity2 , surgery and radiotherapy for @entity1 , and symptomatic treatment for @entity8 and @entity3 . MAIN OUTCOME MEASURES: Polysomnography, multiple sleep latency test, and neurological examination. RESULTS: The @entity1 was detected at a limited stage and treatable. After oncological therapy and immunotherapy, symptoms stabilized. Treatment with @entity13 improved daytime somnolence. CONCLUSIONS: Rapid onset and progression of @entity4 may be a clue to paraneoplastic etiology. Early treatment of a limited stage @entity1 (with or without immunotherapy) may possibly slow progression of @entity2 . Symptomatic treatment may be beneficial.

title: @entity12 , REM @entity5 , and supranuclear gaze palsy associated with @entity15 and XXXX antibodies and @entity6 .

answer: @entity7


abstract: OBJECTIVE: To describe a @entity0 with @entity11 and mesencephalic presentation of a @entity15 and @entity7 antibody-associated paraneoplastic @entity2 . DESIGN: Case report. SETTING: The Colorado Neurological Institute @entity9 Center in Englewood, Colorado, and the Mayo Clinic in Rochester, Minnesota. @entity0 : A 55-year-old @entity0 with a paraneoplastic @entity2 characterized by @entity10 movement @entity5 , @entity12 , and a @entity14 in the setting of @entity6 . INTERVENTION: Immunotherapy for paraneoplastic @entity2 , surgery and radiotherapy for @entity1 , and symptomatic treatment for @entity8 and @entity3 . MAIN OUTCOME MEASURES: Polysomnography, multiple sleep latency test, and neurological examination. RESULTS: The @entity1 was detected at a limited stage and treatable. After oncological therapy and immunotherapy, symptoms stabilized. Treatment with @entity13 improved daytime somnolence. CONCLUSIONS: Rapid onset and progression of @entity4 may be a clue to paraneoplastic etiology. Early treatment of a limited stage @entity1 (with or without immunotherapy) may possibly slow progression of @entity2 . Symptomatic treatment may be beneficial.

title: @entity12 , REM @entity5 , and supranuclear gaze palsy associated with XXXX and @entity7 antibodies and @entity6 .

answer: @entity15


abstract: OBJECTIVE: To describe a @entity0 with @entity11 and mesencephalic presentation of a @entity15 and @entity7 antibody-associated paraneoplastic @entity2 . DESIGN: Case report. SETTING: The Colorado Neurological Institute @entity9 Center in Englewood, Colorado, and the Mayo Clinic in Rochester, Minnesota. @entity0 : A 55-year-old @entity0 with a paraneoplastic @entity2 characterized by @entity10 movement @entity5 , @entity12 , and a @entity14 in the setting of @entity6 . INTERVENTION: Immunotherapy for paraneoplastic @entity2 , surgery and radiotherapy for @entity1 , and symptomatic treatment for @entity8 and @entity3 . MAIN OUTCOME MEASURES: Polysomnography, multiple sleep latency test, and neurological examination. RESULTS: The @entity1 was detected at a limited stage and treatable. After oncological therapy and immunotherapy, symptoms stabilized. Treatment with @entity13 improved daytime somnolence. CONCLUSIONS: Rapid onset and progression of @entity4 may be a clue to paraneoplastic etiology. Early treatment of a limited stage @entity1 (with or without immunotherapy) may possibly slow progression of @entity2 . Symptomatic treatment may be beneficial.

title: XXXX , REM @entity5 , and supranuclear gaze palsy associated with @entity15 and @entity7 antibodies and @entity6 .

answer: @entity12


abstract: OBJECTIVE: To describe a @entity0 with @entity11 and mesencephalic presentation of a @entity15 and @entity7 antibody-associated paraneoplastic @entity2 . DESIGN: Case report. SETTING: The Colorado Neurological Institute @entity9 Center in Englewood, Colorado, and the Mayo Clinic in Rochester, Minnesota. @entity0 : A 55-year-old @entity0 with a paraneoplastic @entity2 characterized by @entity10 movement @entity5 , @entity12 , and a @entity14 in the setting of @entity6 . INTERVENTION: Immunotherapy for paraneoplastic @entity2 , surgery and radiotherapy for @entity1 , and symptomatic treatment for @entity8 and @entity3 . MAIN OUTCOME MEASURES: Polysomnography, multiple sleep latency test, and neurological examination. RESULTS: The @entity1 was detected at a limited stage and treatable. After oncological therapy and immunotherapy, symptoms stabilized. Treatment with @entity13 improved daytime somnolence. CONCLUSIONS: Rapid onset and progression of @entity4 may be a clue to paraneoplastic etiology. Early treatment of a limited stage @entity1 (with or without immunotherapy) may possibly slow progression of @entity2 . Symptomatic treatment may be beneficial.

title: @entity12 , REM @entity5 , and supranuclear gaze palsy associated with @entity15 and @entity7 antibodies and XXXX .

answer: @entity6


abstract: OBJECTIVE: To describe a @entity0 with @entity11 and mesencephalic presentation of a @entity15 and @entity7 antibody-associated paraneoplastic @entity2 . DESIGN: Case report. SETTING: The Colorado Neurological Institute @entity9 Center in Englewood, Colorado, and the Mayo Clinic in Rochester, Minnesota. @entity0 : A 55-year-old @entity0 with a paraneoplastic @entity2 characterized by @entity10 movement @entity5 , @entity12 , and a @entity14 in the setting of @entity6 . INTERVENTION: Immunotherapy for paraneoplastic @entity2 , surgery and radiotherapy for @entity1 , and symptomatic treatment for @entity8 and @entity3 . MAIN OUTCOME MEASURES: Polysomnography, multiple sleep latency test, and neurological examination. RESULTS: The @entity1 was detected at a limited stage and treatable. After oncological therapy and immunotherapy, symptoms stabilized. Treatment with @entity13 improved daytime somnolence. CONCLUSIONS: Rapid onset and progression of @entity4 may be a clue to paraneoplastic etiology. Early treatment of a limited stage @entity1 (with or without immunotherapy) may possibly slow progression of @entity2 . Symptomatic treatment may be beneficial.

title: @entity12 , REM XXXX , and supranuclear gaze palsy associated with @entity15 and @entity7 antibodies and @entity6 .

answer: @entity5


abstract: @entity1 controls an array of key events in keratinocytes and epidermis: localized changes in @entity0 concentrations and their regulation are therefore especially important to assess when observing epidermal barrier homeostasis and repair, neonatal barrier establishment, in differentiation, signaling, cell adhesion, and in various pathological states. Yet, tissue- and cellular @entity0 concentrations in physiologic and diseased states are only partially known, and difficult to measure. Prior observations on the @entity0 distribution in skin were based on @entity0 precipitation followed by electron microscopy, or proton-induced X-ray emission. Neither cellular and/or subcellular localization could be determined through these approaches. In cells in vitro, fluorescent dyes have been used extensively for ratiometric measurements of static and dynamic @entity0 concentrations, also assessing organelle @entity0 concentrations. For lack of better methods, these findings together build the basis for the current view of the role of @entity0 in epidermis, their limitations notwithstanding. Here we report a method using @entity1 Green 5N as the @entity1 sensor and the phasor-plot approach to separate raw lifetime components. Thus, fluorescence lifetime imaging (FLIM) enables us to quantitatively assess and visualize dynamic changes of @entity0 at light-microscopic resolution in ex vivo biopsies of unfixed epidermis, in close to in vivo conditions. Comparing undisturbed epidermis with epidermis following a barrier insult revealed major shifts, and more importantly, a mobilization of high amounts of @entity0 shortly following barrier disruption, from intracellular stores. These results partially contradict the conventional view, where barrier insults abrogate a @entity0 gradient towards the stratum granulosum. @entity0 FLIM overcomes prior limitations in the observation of epidermal @entity0 dynamics, and will allow further insights into basic epidermal physiology.

title: Major translocation of XXXX upon epidermal barrier insult: imaging and quantification via FLIM/Fourier vector analysis.

answer: @entity1


abstract: OBJECTIVES: @entity6 ( @entity6 ) may be associated with @entity1 ( @entity1 ). As there is such an overlap and since both diseases show @entity4 we reasoned similar biological pathways might be implicated in both conditions. Therefore, we investigated the prevalence of anti- @entity5 cerevisiae (ASCA) and anti-neutrophil cytoplasmic (ANCA) antibodies - serological markers for @entity1 -among @entity0 with @entity6 . METHODS: Thirty-two @entity0 with @entity6 , 21 with @entity2 ( @entity2 ), 17 with @entity3 ( @entity3 ) and 34 healthy controls were studied. Among 32 @entity0 with @entity6 , 2 had @entity2 and one had @entity3 concomitantly. ASCA Ig A and Ig G antibodies were analyzed using a commercial ELISA kit. Immune fluorescence analysis (IFA) was used to assess the presence of ANCA antibodies. RESULTS: Only @entity0 with @entity2 had significantly higher levels of both ASCA Ig A and Ig G, compared to @entity0 with @entity6 and healthy controls. Similarly, the frequency of ASCA positive @entity0 was higher only among @entity0 with @entity2 . ASCA Ig A and Ig G antibodies were found in 16 % (5/32) of @entity0 with @entity6 . Among 3 @entity0 , in whom @entity6 and @entity1 co-existed, only one (one with @entity2 ) had positive ASCA Ig G and A antibodies. The p-ANCA antibodies were present among @entity0 with @entity3 (35 %) and @entity2 (10 %). CONCLUSION: ASCA positivity in @entity6 was similar to that found in @entity3 and healthy controls. No ANCA antibodies were detected among @entity0 with @entity6 .

title: Anti- XXXX cerevisiae (ASCA) and anti-neutrophil cytoplasmic (ANCA) antibodies are not increased in @entity6 .

answer: @entity5


abstract: OBJECTIVES: @entity6 ( @entity6 ) may be associated with @entity1 ( @entity1 ). As there is such an overlap and since both diseases show @entity4 we reasoned similar biological pathways might be implicated in both conditions. Therefore, we investigated the prevalence of anti- @entity5 cerevisiae (ASCA) and anti-neutrophil cytoplasmic (ANCA) antibodies - serological markers for @entity1 -among @entity0 with @entity6 . METHODS: Thirty-two @entity0 with @entity6 , 21 with @entity2 ( @entity2 ), 17 with @entity3 ( @entity3 ) and 34 healthy controls were studied. Among 32 @entity0 with @entity6 , 2 had @entity2 and one had @entity3 concomitantly. ASCA Ig A and Ig G antibodies were analyzed using a commercial ELISA kit. Immune fluorescence analysis (IFA) was used to assess the presence of ANCA antibodies. RESULTS: Only @entity0 with @entity2 had significantly higher levels of both ASCA Ig A and Ig G, compared to @entity0 with @entity6 and healthy controls. Similarly, the frequency of ASCA positive @entity0 was higher only among @entity0 with @entity2 . ASCA Ig A and Ig G antibodies were found in 16 % (5/32) of @entity0 with @entity6 . Among 3 @entity0 , in whom @entity6 and @entity1 co-existed, only one (one with @entity2 ) had positive ASCA Ig G and A antibodies. The p-ANCA antibodies were present among @entity0 with @entity3 (35 %) and @entity2 (10 %). CONCLUSION: ASCA positivity in @entity6 was similar to that found in @entity3 and healthy controls. No ANCA antibodies were detected among @entity0 with @entity6 .

title: Anti- @entity5 cerevisiae (ASCA) and anti-neutrophil cytoplasmic (ANCA) antibodies are not increased in XXXX .

answer: @entity6


abstract: INTRODUCTION: Since June 2008, Portuguese rheumatologists have been collecting on a routine basis, data into the nationwide Reuma.pt, the @entity2 Portuguese Register from the Portuguese Society of Rheumatology ( @entity7 ), which includes @entity2 @entity0 ( @entity1 - @entity1 , @entity3 - @entity6 , @entity5 - PsA and @entity4 ) receiving biological therapies or @entity0 receiving synthetic disease modifying anti- @entity2 drugs (DMARDs). The aim of this publication is to describe the structure of Reuma.pt and the population registered since June 2008. METHODS: Demographic and anthropometric data, life style habits, work status, co-morbidities, disease activity and functional assessment scores, previous and current therapies, adverse events codified by the Medical Dictionary for Regulatory Activities (MedDRA), reasons for discontinuation and laboratory measurements are registered at each visit. The platform is based on a structured electronic medical record linked to a SQL Server database. All Rheumatology Departments assigned to the Portuguese National Health Service (n=21), 2 Military Hospitals (Lisboa and Porto), 1 public-private Institution and 6 private centers adhered to the Register. Until now, 18 centers have entered data into Reuma.pt. RESULTS: By January 2011, 3438 @entity0 and 16130 visits had been registered. 2162 (63%) were @entity1 @entity0 , 700 of them treated with biological agents and 1462 with synthetic DMARDs. From the 515 (15%) @entity6 @entity0 , 297 were medicated with biological and 218 with non-biological therapies. 293 (8%) were PsA @entity0 , 151 treated with biological drugs and 142 with other treatment strategies. 368 (11%) had the diagnosis of JIA, 68 were under biological treatment and 300 were managed with other treatment options. The register also includes 100 (3%) @entity0 with other @entity2 , submitted to treatments that required hospital day care infusions including 18 exposed to biological therapies. CONCLUSIONS: Registers are crucial to ensure correct clinical use, adequate assessment of post-marketing biological therapies' efficacy and safety, thus contributing for a better cost-benefit ratio. Reuma.pt, is a powerful and accurate tool to answer to these unmet needs. It presents a national coverage of the rheumatology centers and constitutes an invaluable resource for scientific research and to improve @entity2 @entity0 care.

title: Reuma.pt - the XXXX portuguese register.

answer: @entity2


abstract: Although the @entity2 locomotor system has been shown to differ from @entity0 , characteristics of @entity2 entheses, the skeletal attachments for muscles, tendons, ligaments and joint capsules, have never been specifically investigated. Here, we analyse lower limb entheses of the Krapina @entity2 bones (Croatia, 130,000 BP) with the aim of determining how they compare with modern @entity0 , using a standard developed by our research group for describing modern @entity0 entheseal variability. The entheses examined are those of the gluteus maximus, iliopsoas and vastus medialis on the femur, the quadriceps @entity1 , and soleus on the tibia. For the entheses showing a different morphological pattern from @entity0 , we discuss the possibility of recognising genetic versus environmental causes. Our results indicate that only the gluteus maximus enthesis (the gluteal tuberosity), falls out of the modern @entity0 range of variation. It displays morphological features that could imply histological differences from modern @entity0 , in particular the presence of fibrocartilage. In both @entity0 and the Krapina @entity2 , the morphological pattern of this enthesis is the same in adult and immature femurs. These results can be interpreted in light of genetic differences between the two hominins. The possibility of functional adaptations to higher levels of mechanical load during life in the @entity2 seems less likely. The particular morphology and large dimensions of the Krapina enthesis, and perhaps its fibrocartilaginous nature, could have been selected for in association with other pelvic and lower limb characteristics, even if genetic drift cannot be ruled out.

title: Lower limb entheseal morphology in the XXXX Krapina population (Croatia, 130,000 BP).

answer: @entity2


abstract: BACKGROUND: The effects of right ventricular (RV) pacing on left ventricular (LV) diastolic function are unknown. This study aimed to test the hypothesis that right ventricular (RV) pacing is associated with LV @entity1 and impairment of LV torsion in @entity0 and young adults with @entity4 . METHODS: Eighteen @entity0 aged 20    7 years and 12 healthy controls aged 19    7 years were studied. Transmitral and mitral annular diastolic velocities and global longitudinal diastolic strain rate were determined and compared between the 2 groups. Parameters of LV torsion including peak systolic basal and @entity2 , and systolic twisting and diastolic untwisting velocities were further determined by speckle tracking echocardiography. In 12 @entity0 , these parameters were compared before and after interruption of RV pacing. RESULTS: Compared with controls, @entity0 had significantly lower mitral early diastolic annular velocity (p=0.007), LV global diastolic strain rate (p<0.001), basal (p<0.001) and apical (p=0.002) rotations, peak systolic torsion (p<0.001), and peak systolic twisting velocities (p=0.009). In @entity0 , the peak diastolic untwisting velocity correlated with peak systolic torsion (r=0.64, p=0.004) and peak systolic twisting velocity (r=0.74, p<0.001). No significant improvement in LV diastolic function or torsion was observed during pacing interruption (all p>0.05). CONCLUSION: Right ventricular pacing in childhood is associated with LV @entity1 and @entity3 , which do not improve with pacing interruption.

title: Left ventricular torsional mechanics and diastolic function in XXXX with right ventricular pacing.

answer: @entity4


abstract: Previous studies have demonstrated @entity4 in rectal biopsy specimens from 2 to 7 percent of heterosexual and 36 percent of homosexual @entity0 , but the role of @entity4 in the pathogenesis of @entity4 remains unclear. To assess the clinical, histologic, and microbiologic correlates of @entity4 in a high-risk group, rectal biopsy specimens from 130 homosexual @entity0 , 92 percent of whom had intestinal symptoms, were evaluated. All @entity0 were extensively evaluated for rectal and enteric pathogens. Intestinal spirochetosis was identified in rectal biopsy specimens from 39 (30 percent) @entity0 ; 15 percent of biopsy specimens revealed @entity4 on @entity2 and @entity3 plus alcian blue staining, and positive results were found in 30 percent on @entity1 staining. No rectal biopsy specimens from 79 control @entity0 with a variety of gastrointestinal symptoms demonstrated evidence of spirochetosis on @entity2 and @entity3 , alcian blue, or @entity1 staining (p less than 0.0001). Fifty-six percent of rectal biopsy specimens from @entity0 with @entity4 were normal, and no specific histologic abnormality was correlated with @entity4 . There were no differences in the presence of or type of intestinal symptoms, sigmoidoscopic appearance of the mucosa, type of sexual practice, or prior antibiotic use in @entity0 with and without spirochetosis. Other intestinal pathogens were frequent in both groups, and only @entity5 was significantly associated with @entity4 . It is concluded that homosexual @entity0 with intestinal symptoms have an increased prevalence of spirochetosis, often in association with @entity6 . Independent association of spirochetosis with clinical or histologic findings could not be demonstrated.

title: Intestinal spirochetosis in homosexual XXXX .

answer: @entity0


abstract: BACKGROUND: Sleep disturbance may affect smoking cessation efforts. We describe sleep changes across three months among @entity0 in a smoking cessation program and tested whether @entity2 at baseline and 1 month post-quit attempt predicted smoking status at three months. METHODS: @entity0 (N=322) were @entity0 in a randomized, clinical trial for smoking cessation. Sleep disturbances, as well as, @entity1 , drowsiness, and sleep quality were evaluated prior to and during three months of cessation treatment. Repeated measures mixed models evaluated change in sleep over time by smoking outcome status. Logistic regression analyses determined whether @entity2 at baseline and 1 month post-quit were associated with smoking status at 3 months. RESULTS: Sleep disturbances were reported by more than 25% of @entity0 . Drowsiness, @entity1 , and sleep quality changed over time. However, contrary to our hypotheses, none of the sleep variables at either baseline or 1 month post-quit attempt was associated with relapse (p's>.05). CONCLUSIONS: Although mild to severe drowsiness was reported by more @entity0 who relapsed than those who remained abstinent, none of the @entity2 predicted smoking relapse. Given high rates of @entity2 among @entity0 smokers, better prospective evaluations of the relationship of @entity2 to smoking cessation treatment outcome are needed.

title: Subjective XXXX during a smoking cessation program: associations with relapse.

answer: @entity2


abstract: The accurate prediction of individual outcomes after @entity2 surgery represents a key challenge facing clinicians. It requires a precise understanding of surgical candidacy and the optimal timing of surgery to maximize a range of outcomes, including medical, psychosocial, cognitive, and @entity1 outcomes. We promote careful consideration of how @entity2 has affected an individual's developmental trajectory as key to constructing more differentiated profiles of postsurgical risk or resilience across multiple outcome measures. This life span approach conceives surgery as a crucial "turning point" in an individual's development from which varied outcome trajectories may follow. This helps clinicians understand the expectations @entity0 and families bring to surgery, and emphasizes the interplay of factors that determine a @entity0 's outcome. It also promotes comprehensive, longitudinal assessment of outcome using data analytical techniques that capture individual differences and identify subgroups with similar trajectories. An ongoing challenge facing clinicians is the development of an outcome classification system that incorporates outcomes other than @entity4 . We illustrate two emerging areas of research shaping how we define surgical candidacy and predict outcome: (1) using cortico-cortical evoked potentials to identify pathways of @entity4 propagation and cortico-cortical networks mediating cortical functions, and (2) predicting @entity3 using a model that incorporates psychosocial and neurobiological factors. The latter research points to the importance of routine follow-up and postoperative psychosocial rehabilitation, particularly in @entity0 deemed at "high risk" for poor outcomes so that early treatment interventions can be implemented. Significantly more research is needed to characterize those @entity0 with poor outcomes who may require re-surgery.

title: Current challenges in the practice of XXXX surgery.

answer: @entity2


abstract: @entity5 in @entity4 is a repetitive behavior pattern which may involve the activation of both narcotic receptors and @entity2 receptors in the CNS. @entity5 frequency, determined in 7 nontreated @entity4 under controlled conditions, was usually linear for many hours and ranged from 0.3 to 14.9 bites/min. Intravenous or IM injections of narcotic antagonists decreased these rates to almost zero by about 20 minutes after the injection was given. The duration of the response to a single injection ranged from 20 minutes for @entity3 to 4 hours or more for @entity7 and @entity6 . Effective doses were 0.02 to 0.04 mg of @entity3 /kg, 0.04 mg of @entity1 /kg, 0.08 mg of @entity7 /kg, and 0.02 to 0.03 mg of @entity6 /kg. @entity5 could be prevented completely for up to a week by continuous infusion of 5 to 10 mg of @entity7 /hr. @entity5 resumed when the infusion was discontinued, and plasma @entity7 concentrations decreased to below 5 ng/ml. Doses of @entity7 as large as 0.4 mg/kg, IV, produced only minor side effects. These side effects included some passage of semifluid fecal material, intermittent penile relaxation, and mild sedation. Treated @entity4 responded normally to external stimuli, retained their appetites, and performed appropriately when ridden. Sedation wore off during the course of prolonged infusions. Narcotic antagonists may provide a novel and effective treatment of @entity0 .

title: Investigation into the use of narcotic antagonists in the treatment of a stereotypic behavior pattern (crib-biting) in the XXXX .

answer: @entity4


abstract: Drugs which inhibit carbonic anhydrase (CA) reduce cerebrospinal fluid (CSF) flow. This study relates the inhibition of CSF flow in @entity1 after 1 to 30 mg/kg of @entity3 , @entity2 or @entity4 (inhibitors of differing pharmacokinetic properties) to plasma and choroid plexus levels of these drugs. From plasma concentrations of unbound drug and the dissociation constants for the interaction of drugs with choroid plexus CA, it is shown that the concentration of residual active CA in choroid plexus of @entity1 must be reduced from approximately 22 microM to the range of 5 to 10 nM to reduce CSF flow significantly. This represents at least 99.95% inhibition of CA of choroid plexus. This level of inhibition was achieved by an i.v. dose of 30 mg/kg of @entity3 , @entity2 or @entity4 , whereas doses of 10 mg/kg of @entity3 or @entity2 did not significantly decrease mean residual CSF flow. The data suggest that it is the residual flow after inhibition, not the absolute or percentage of decrease in flow, which should be used to evaluate the effectiveness of CA inhibition, because of the variability in individual control rates. Maximal effects of CA inhibition in cat reduce flow to 9 to 11 microliter/min from a mean of 21.7 microliter/min. In choroid plexus of @entity0 , the CA concentration is, at most, 40% that of cat. An attempt has been made to use CA concentration, drug binding data and other pharmacokinetic factors in predicting appropriate choices of drug and dose for @entity0 , extrapolating from the data for @entity1 . These predictions are compared to existing data for plasma levels or CSF effects of CA inhibitors in @entity0 .

title: The relation of choroid plexus carbonic anhydrase activity to cerebrospinal fluid formation: study of three inhibitors in cat with extrapolation to XXXX .

answer: @entity0


abstract: BACKGROUND: @entity4 is a @entity3 that is characterised by a deficit in the fluent sequencing of thought and action. This problem of discoordination might be due to unreliable timing processes associated with a difficulty in allocating sufficient attention. In the present study, we placed ourselves within the hypothesis that @entity4 @entity0 may have difficulties in producing rhythmic tapping actions and that this deficit may be correlated with the degree of @entity5 . METHOD: Subjects were required to tap in rhythm with alternating force levels and/or alternating time intervals (<1s) during trials lasting 24s. In addition, all @entity0 performed an attention task (D2 test). A qualitative analysis of the tap trials was conducted in order to characterise the nature of the deficits that @entity0 revealed. RESULTS: Results showed that all @entity0 revealed significant difficulties in performing the tapping trials. The number of trials removed was correlated with the level of attention dysfunction. Finally, our qualitative analysis revealed that 60% of @entity0 presented attentional lapses - which were never observed in the healthy controls. CONCLUSION: This study revealed @entity1 that resemble, at least on a behaviour level, the clinical lapses observed in @entity4 . These lapses seem to be correlated to the degree of @entity2 . Future studies are now required in order to gain better understanding of the nature of the @entity2 in @entity4 . More specifically, a better definition of the possible functional relationship between clinical lapses, cognitive lapses and action freezing is needed to develop innovating tools for rehabilitation.

title: [Production of rhythms in XXXX : the central role of attention].

answer: @entity4


abstract: OBJECTIVE: To evaluate the use of transcranial magnetic stimulation for differentiating between clinically relevant and clinically irrelevant cervical @entity1 on magnetic resonance imaging (MRI). DESIGN: Validation study. ANIMALS: Clinically normal Doberman Pinschers without (n = 11) and with (6) @entity1 on MRI and 16 Doberman Pinschers with @entity2 ( @entity2 ). PROCEDURES: After @entity0 were sedated, transcranial magnetic motor evoked potentials were recorded from the extensor carpi radialis muscle (ECRM) and cranial tibial muscle (CTM). Onset latencies and peak-to-peak amplitudes were measured. Magnetic resonance imaging was performed to identify @entity1 . RESULTS: There were significant differences in ECRM and CTM onset latencies between Doberman Pinschers with @entity2 and each of the 2 groups of clinically normal @entity0 , but there were no significant differences in ECRM and CTM onset latencies between the 2 groups of clinically normal @entity0 . There were significant differences in CTM peak-to-peak amplitudes between Doberman Pinschers with @entity2 and each of the 2 groups of clinically normal @entity0 , but there were no significant differences in ECRM peak-to-peak amplitudes among groups or in CTM peak-to-peak amplitudes between the 2 groups of clinically normal @entity0 . There was a significant correlation between severity of @entity1 and ECRM onset latency, CTM onset latency, and CTM peak-to-peak amplitude. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that transcranial magnetic stimulation may be a useful diagnostic tool to differentiate between clinically relevant and clinically irrelevant @entity1 identified on MRI alone.

title: Transcranial magnetic stimulation in Doberman Pinschers with clinically relevant and clinically irrelevant XXXX on magnetic resonance imaging.

answer: @entity1


abstract: OBJECTIVE: To investigate a drilling guide in the treatment of @entity5 with closed reduction and Kirschner fixation and explore the therapeutic effect. METHODS: From June 2008 to December 2009, 36 @entity0 with @entity5 (Tossy III) were treated with closed reduction and Kirschner fixation using a self-designed drilling guide as well as percutaneous repair of acromioclavicular joint. Among the @entity0 , 24 @entity0 were male and 12 @entity0 were female,ranging in age from 20 to 61 years, averaged 38.6 years. The duration from injury to operation ranged from 3.5 to 72 h,with a mean of 15.2 h. No @entity1 was found in all cases. The operative time, @entity4 and therapeutic effects were observed. RESULTS: There were no complications including @entity3 . The mean operating time were 20 min,mean @entity2 were about 10 ml. According to the observation of postoperative X-ray examination, all Kirschners in acromioclavicular joint were in place. All Kirschners were removed in 6 postoperative weeks. All the @entity0 were followed up ranging from 2 to 26 months (averaged 14.3 months). According to the Karlsson standard,22 @entity0 got an excellent result, 13 good and 1 poor. CONCLUSION: This method has following advantages: easy operation and fixation; minimum injuries to articular surface; and which would be widely used in clinical practice.

title: [Design and clinical application of the drilling guide in the treatment of XXXX with closed reduction and Kirschner fixation].

answer: @entity5


abstract: OBJECTIVE: To explore the minimally invasive treatment for fresh @entity4 and the @entity2 . METHODS: Thirty skeletons of @entity0 shoulder were measured and compared, and the normal data on healthy @entity0 were measured with the help of ultrasound-guided. So the invasion point was located at the cross between @entity3 and the line from coracoid tip to apophysis behind cone ligament node. From January 2001 to January 2010, 127 @entity0 with fresh @entity4 and @entity2 were treated with minimally invasive internal fixation after locating the invasive point at the body surface. Among the @entity0 , 97 @entity0 were male and 30 @entity0 were female, ranging in age from 19 to 56 years, with an average of 43 years. According to Rockwood classification, among 93 @entity0 with fresh @entity4 , 67 @entity0 were type III, 11 @entity0 were type IV and 15 @entity0 were type V. All the 34 @entity0 with @entity2 were associated with coracoclavicular ligament broken. The duration from injury to operation ranged from 1 to 8 days. The therapeutic effects were evaluated by using the of shoulder scoring system, University of California (UCLA). RESULTS: After the minimally invasive treatment, all the @entity0 had completely reduction at early time. One hundred and thirteen @entity0 were followed up,and the duration ranged from 13 to 15 months,averaged 14 months. Nine @entity0 had screw loose slightly within 30 days, but the reductions and functions were acceptable. Seven @entity0 had complications of frozen shoulder and recovered in 6 months. The average UCLA shoulder score was (32.0 +/- 4.7), and 87 @entity0 got an excellent result, 20 good and 6 fair. CONCLUSION: This minimally invasive treatment has advantages such as @entity1 and low cost, which is worthy of clinical applications.

title: [Minimally invasive treatment for fresh @entity4 and the XXXX ].

answer: @entity2


abstract: OBJECTIVE: To explore the minimally invasive treatment for fresh @entity4 and the @entity2 . METHODS: Thirty skeletons of @entity0 shoulder were measured and compared, and the normal data on healthy @entity0 were measured with the help of ultrasound-guided. So the invasion point was located at the cross between @entity3 and the line from coracoid tip to apophysis behind cone ligament node. From January 2001 to January 2010, 127 @entity0 with fresh @entity4 and @entity2 were treated with minimally invasive internal fixation after locating the invasive point at the body surface. Among the @entity0 , 97 @entity0 were male and 30 @entity0 were female, ranging in age from 19 to 56 years, with an average of 43 years. According to Rockwood classification, among 93 @entity0 with fresh @entity4 , 67 @entity0 were type III, 11 @entity0 were type IV and 15 @entity0 were type V. All the 34 @entity0 with @entity2 were associated with coracoclavicular ligament broken. The duration from injury to operation ranged from 1 to 8 days. The therapeutic effects were evaluated by using the of shoulder scoring system, University of California (UCLA). RESULTS: After the minimally invasive treatment, all the @entity0 had completely reduction at early time. One hundred and thirteen @entity0 were followed up,and the duration ranged from 13 to 15 months,averaged 14 months. Nine @entity0 had screw loose slightly within 30 days, but the reductions and functions were acceptable. Seven @entity0 had complications of frozen shoulder and recovered in 6 months. The average UCLA shoulder score was (32.0 +/- 4.7), and 87 @entity0 got an excellent result, 20 good and 6 fair. CONCLUSION: This minimally invasive treatment has advantages such as @entity1 and low cost, which is worthy of clinical applications.

title: [Minimally invasive treatment for fresh XXXX and the @entity2 ].

answer: @entity4


abstract: Millions of @entity0 in the U.S. suffer from @entity1 . A disproportionately large number of those @entity0 are from low-income and racial minority families. With or without @entity1 , @entity0 from low-income families are at risk for delayed school readiness and less than optimal academic achievement trajectories. The aim of this article was to review the literature on educational interventions for young @entity0 with @entity1 and their families to determine if there was sufficient evidence to guide practice. In addition, a new theoretical model upon which to base new interventions is proposed. Literature was reviewed from Medline, CINAHL, PsycInfo, and the Cochrane Reviews databases. A limited number of randomized, controlled studies of educational interventions for @entity0 and their families was found, and only one study was specifically aimed at preschool-age @entity0 . Comparisons among studies are difficult because of varying methodologies, and findings are non-conclusive. In conclusion, comprehensive, multidisciplinary, multi-level interventions are needed to minimize the effects of childhood @entity1 , especially for @entity0 from low-income families. Large-scale, randomized, controlled studies are needed to provide empirical evidence for the efficacy of specific interventions for preschoolers prior to school entry to minimize the detrimental effects of uncontrolled @entity1 on school achievement.

title: Educational interventions for childhood XXXX : a review and integrative model for preschoolers from low-income families.

answer: @entity1


abstract: The increasing prevalence of maternal @entity2 worldwide provides a major challenge to obstetric practice from preconception to postpartum. @entity2 can result in unfavorable outcomes for the @entity0 and fetus. Maternal risks during pregnancy include gestational @entity1 and chronic @entity3 leading to @entity7 . The fetus is at risk for @entity8 and @entity4 . Intrapartum care, normal and operative deliveries, anesthetic and operative interventions in the @entity2 demand extra care. Obesity in pregnancy can also affect health later in life for both mother and @entity0 . For @entity0 , these risks include @entity5 and @entity3 . @entity0 have a risk of future @entity2 and @entity5 . @entity0 and their offspring are at increased risk for @entity1 . Obstetrician-gynecologists should be well informed to prevent and treat this epidemic. Interventions directed at weight loss and prevention of excessive @entity6 during pregnancy must begin in the preconception period.

title: XXXX and pregnancy outcome.

answer: @entity2


abstract: OBJECTIVES: Despite the fact that many studies have addressed the use of ECT in @entity1 questions on clinical use remain poorly answered and clinical application is largely based on data originating from @entity2 @entity0 . METHODS: We review data on the use of ECT in @entity1 @entity0 drawn from original studies indicated by a Pubmed search and referenced in recent and older expert reviews with a specific focus on four issues: symptom response, technical application, continuation/maintenance ECT and combination with medication. RESULTS: @entity5 @entity0 are the most responsive. Positive symptoms such @entity6 and affective symptoms follow. There are indications that ECT may improve responsivity to medication. No particular technical features stand out in studies except lengthier courses, but not for @entity4 . Combination with medication appears to be preferable over either treatment alone and effective combination particularly with @entity3 is supported by data. Use of continuation and maintenance treatments in responders appears beneficial. CONCLUSION: Certain @entity1 @entity0 may benefit significantly from the use of ECT. More specific research is required to address particular questions.

title: Using ECT in XXXX : a review from a clinical perspective.

answer: @entity1


abstract: BACKGROUND: Soy foods have been substituted for meat in recent years because of proposed health benefits. Research indicates, however, that soy protein and phytate in soy products inhibit the absorption of divalent cations. METHODS: Our study was primarily designed to determine the effect of consuming two to three servings per day of soy foods, providing    19   g protein and    36   mg @entity8 , on @entity1 and @entity4 status in premenopausal @entity0 during a 10-weeks period. As secondary outcomes, we also tested the effect of soy foods on biochemical markers of bone and thyroid hormones. Nonsmoking @entity0 (18-28 years) without @entity3 , @entity5 , pregnancy, or irregular menstrual cycles were randomly assigned to either the soy food (SF, n=31) or @entity7 ( @entity7 , n=32) group. Blood and urine samples and 3-day dietary records were collected at baseline and postintervention. RESULTS: At baseline, @entity1 and @entity4 status, bone markers, and thyroid hormones were not different between groups. After intervention, no significant changes were observed in hemoglobin, @entity2 saturation, serum @entity1 , ferritin, or @entity9 ( @entity9 ) concentrations. Plasma @entity4 , but not serum alkaline phosphatase, significantly decreased in both groups (-0.8    mol/L). The change in bone-specific alkaline phosphatase was significant between SF (1.5   U/L) and @entity7 (-0.7   U/L) groups. No significant changes were observed in bone resorption, thyroid-stimulating hormone (TSH), or free @entity6 after soy food intake. CONCLUSIONS: Incorporating    19   g soy protein from soy foods for 10 weeks had no significant effect on @entity1 or @entity4 status, bone resorption or formation, or thyroid hormone status in premenopausal @entity0 .

title: The effect of soy food intake on mineral status in premenopausal XXXX .

answer: @entity0


abstract: OBJECTIVE: To study the presentation of @entity2 among @entity1 @entity0 in Pakistan and to explore limitations in the diagnosis of these @entity0 by the physicians of a developing country. METHODS: We conducted a cross-sectional study on @entity0 admitted to Aga Khan University Hospital, Karachi, Pakistan from January 2005 to September 2008. Records of 663 @entity1 @entity0 were reviewed. Demographic data, @entity3 , radiographic studies, and final outcome were studied. Presentation and radiological modality confirming the diagnosis of @entity2 were noted. Descriptive statistics followed by Chi-Square test were applied, testing against an alpha of 0.05 and 95% confidence interval (CI). RESULTS: Three hundred and fifty-four (53%) out of a total of 663 @entity1 @entity0 did not complain of any respiratory symptoms at presentation, nor did their medical examination elicit any suspicion of PE. Hence, no radiological study was advised. Amongst the remaining 309 @entity0 , 299 (97%) underwent chest x-ray and 10 (3%) had abdominal ultrasound. The @entity2 was noted in 50 (16%) @entity0 (31 male and 19 female @entity0 , with a mean age of 32+/-15 years). A @entity2 was found in 23/50 (46%) @entity0 , left sided in 9/50 (18%), and 18/50 (36%) @entity0 had @entity2 on both sides. Out of the radiologically confirmed @entity2 @entity0 , 44/50 (88%) showed altered hemo-concentration with an insignificant odds ratio of 0.7 (p=0.56, 95% CI: 0.263-2.066). CONCLUSION: Compared to other studies, fewer numbers of our @entity0 suffered from @entity2 . The diagnostic modality preferred by the physician was the chest x-ray.

title: @entity2 in XXXX . Karachi perspective.

answer: @entity1


abstract: OBJECTIVE: To study the presentation of @entity2 among @entity1 @entity0 in Pakistan and to explore limitations in the diagnosis of these @entity0 by the physicians of a developing country. METHODS: We conducted a cross-sectional study on @entity0 admitted to Aga Khan University Hospital, Karachi, Pakistan from January 2005 to September 2008. Records of 663 @entity1 @entity0 were reviewed. Demographic data, @entity3 , radiographic studies, and final outcome were studied. Presentation and radiological modality confirming the diagnosis of @entity2 were noted. Descriptive statistics followed by Chi-Square test were applied, testing against an alpha of 0.05 and 95% confidence interval (CI). RESULTS: Three hundred and fifty-four (53%) out of a total of 663 @entity1 @entity0 did not complain of any respiratory symptoms at presentation, nor did their medical examination elicit any suspicion of PE. Hence, no radiological study was advised. Amongst the remaining 309 @entity0 , 299 (97%) underwent chest x-ray and 10 (3%) had abdominal ultrasound. The @entity2 was noted in 50 (16%) @entity0 (31 male and 19 female @entity0 , with a mean age of 32+/-15 years). A @entity2 was found in 23/50 (46%) @entity0 , left sided in 9/50 (18%), and 18/50 (36%) @entity0 had @entity2 on both sides. Out of the radiologically confirmed @entity2 @entity0 , 44/50 (88%) showed altered hemo-concentration with an insignificant odds ratio of 0.7 (p=0.56, 95% CI: 0.263-2.066). CONCLUSION: Compared to other studies, fewer numbers of our @entity0 suffered from @entity2 . The diagnostic modality preferred by the physician was the chest x-ray.

title: XXXX in @entity1 . Karachi perspective.

answer: @entity2


abstract: BACKGROUND: The present study was performed to compare blood product consumption and clinical results in consecutive, unselected @entity1 @entity0 during the first 6 months of year 2002, 2004 and 2007. METHODS: Clinical data, blood product consumption, lowest haemoglobin values on day 1-10 after admission, and 30-day mortality were extracted from in-hospital @entity1 registry and the blood bank data base. The subpopulation of massively transfused @entity0 was identified and analysed separately. RESULTS: The total number of admitted @entity1 @entity0 increased by 48% from 2002 to 2007, but the clinical data remained essentially unchanged. The mean number of erythrocyte units given day 1-10 decreased insignificantly from 9.4 in 2002 to 6.8 in 2007. New Injury Severity Score (NISS) increased in transfused and massively transfused @entity0 , but not significantly. The number of @entity0 transfused with plasma increased and the mean ratio of erythrocyte to plasma units transfused decreased by about 50%. The mean haemoglobin value in transfused @entity0 on day 2 after admittance was significantly lower in 2007 than in 2002, while that on day 10 was significantly higher in 2007 than in 2002 and 2004. There was no change of 30-day survival from 2002 to 2007. CONCLUSIONS: Significant changes of transfusion practice occurred during the past decade, probably as a result of increased focus on haemostasis and more precise criteria for transfusion. Despite a lower consumption of erythrocytes in 2007 than in 2002 and 2004, the mean haemoglobin level of transfused @entity0 was higher on day 10 in 2007. The low number of transfused @entity0 in this material makes evaluation of effect on survival difficult. Larger studies with strict control of all influencing factors are needed.

title: Trends in transfusion of XXXX victims--evaluation of changes in clinical practice.

answer: @entity1


abstract: The fast evolving @entity0 @entity2 gene family encodes variable lymphocyte receptors specific for polymorphic HLA class I determinants. Nucleotide sequences for 24 representative @entity0 @entity2 haplotypes were determined. With three previously defined haplotypes, this gave a set of 12 group A and 15 group B haplotypes for assessment of @entity2 variation. The seven gene-content haplotypes are all combinations of four centromeric and two telomeric motifs. 2DL5, 2DS5 and 2DS3 can be present in centromeric and telomeric locations. With one exception, haplotypes having identical gene content differed in their combinations of @entity2 alleles. Sequence diversity varied between haplotype groups and between centromeric and telomeric halves of the @entity2 locus. The most variable A haplotype genes are in the telomeric half, whereas the most variable genes characterizing B haplotypes are in the centromeric half. Of the highly polymorphic genes, only the 3DL3 framework gene exhibits a similar diversity when carried by A and B haplotypes. Phylogenetic analysis and divergence time estimates, point to the centromeric gene-content motifs that distinguish A and B haplotypes having emerged ~6 million years ago, contemporaneously with the separation of @entity0 and @entity1 ancestors. In contrast, the telomeric motifs that distinguish A and B haplotypes emerged more recently, ~1.7 million years ago, before the emergence of @entity0 . Thus the centromeric and telomeric motifs that typify A and B haplotypes have likely been present throughout @entity0 evolution. The results suggest the common ancestor of A and B haplotypes combined a B-like centromeric region with an A-like telomeric region.

title: Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the XXXX killer cell Ig-like receptor locus.

answer: @entity0


abstract: AIM OF THE STUDY: The aim of this study was to study exercise-related cardiac arrests on the tennis court and investigate the impact of early initiation of cardiopulmonary resuscitation on survival rate and outcome. METHODS: This study was based on the @entity1 registry of the Department of Emergency Medicine at the General Hospital Vienna in Austria. Between February 1993 and April 2010 non-professional athletes were identified, who experienced exercise-related @entity1 on the tennis court. The analysis was accomplished using descriptive statistics. Results are presented as mean  standard-deviation or median and interquartile range (IQR). RESULTS: The subjects (n=27) were predominantly male (96%) with a median age of 58 years; 52% of all @entity0 had underlying cardiovascular risk factors. All cardiac arrests were witnessed. Bystander CPR was documented in 17 cases (63%). Median time from collapse to initiation of CPR was 1(IQR 0-2) minute. @entity2 was the initial rhythm in 25 @entity0 (93%) and in 3 an automated external defibrillator was used by bystanders. Twenty-four @entity0 (89%) had return of spontaneous circulation before admission to the hospital and four (15%) followed verbal commands thereafter. The survival rate at 6 months was 82% with 20 @entity0 (74%) having favourable neurologic outcome. CONCLUSIONS: @entity1 on the tennis court is a predominantly witnessed event with a respectively high rate of bystander CPR, which reflects in a high successful survival rate.

title: Exercise related XXXX in amateur athletes on the tennis court.

answer: @entity1


abstract: PURPOSE: To obtain estimates of time to recruit the study sample, retention, facility-based class attendance and home practice for a study of yoga in @entity0 survivors, and its efficacy on fatigue, quality of life (QOL), and weight change. METHODS: Sixty-three post-treatment stages 0-III borderline overweight and @entity2 (body mass index >=  24 kg/m(2)) @entity0 survivors were randomly assigned to a 6-month, facility- and home-based viniyoga intervention (n = 32) or a waitlist control group (n = 31). The yoga goal was five practices per week. Primary outcome measures were changes in QOL, fatigue, and weight from baseline to 6 months. Secondary outcomes included changes in waist and hip circumference. RESULTS: It took 12 months to complete recruitment. @entity1 attended a mean of 19.6 classes and practiced at home a mean of 55.8 times during the 6-month period. At follow-up, 90% of @entity1 completed questionnaires and 87% completed anthropometric measurements. QOL and fatigue improved to a greater extent among @entity1 in the yoga group relative to @entity1 in the control group, although no differences were statistically significant. Waist circumference decreased 3.1 cm (95% CI, -5.7 and -0.4) more among @entity1 in the yoga compared with the control group, with no difference in weight change. CONCLUSIONS: This study provides important information regarding recruitment, retention, and practice levels achieved during a 6-month, intensive yoga intervention in overweight and @entity0 survivors. Yoga may help decrease waist circumference and improve quality of life; future studies are needed to confirm these results.

title: Randomized controlled pilot trial of yoga in overweight and XXXX survivors: effects on quality of life and anthropometric measures.

answer: @entity0


abstract: BACKGROUND: Laparoscopic resection of gastric @entity4 appears technically feasible and associated with favorable outcomes. @entity1 size however frequently plays a role in surgical approach with @entity1 tending toward laparotomy, raising concern that favorable outcomes reported for the laparoscopic approach may reflect this selection bias. MATERIALS AND METHODS: From a prospectively collected sarcoma database, 155 primary @entity3 resections were identified (1998-2009); 40 @entity0 underwent successful laparoscopic resection for non-GE junction GIST and were randomly matched (1:1) by @entity1 size (  2.0  cm) to @entity0 with open resection. Clinical and pathologic variables and surgical outcomes were associated with surgery type using conditional logistic regression analyses. RESULTS: The two surgical approaches were comparable for clinical and pathologic variables. Median operating room (OR) time was similar, although median length of stay postsurgery was lower in the laparoscopic versus open group (4 vs. 7  days, P  =  0.002), as was estimated @entity2 (EBL) (25 vs. 100  ml, P  =  0.006). There was no operative mortality, and 30-day morbidity was similar. Oncologic outcomes were also similar with no positive microscopic margins, and 1 recurrence in each group with a median follow-up of 34  months. There were 13 conversions overall, 5 secondary to @entity1 location at the GE junction or lesser curve. CONCLUSIONS: When matched for @entity1 size, laparoscopic resection of primary gastric @entity4  <=8  cm results in shorter hospital stays with similar OR time while maintaining sound oncologic outcomes compared with open resection.

title: Laparoscopic versus open gastric resections for primary @entity4 ( XXXX ): a size-matched comparison.

answer: @entity4


abstract: BACKGROUND: Laparoscopic resection of gastric @entity4 appears technically feasible and associated with favorable outcomes. @entity1 size however frequently plays a role in surgical approach with @entity1 tending toward laparotomy, raising concern that favorable outcomes reported for the laparoscopic approach may reflect this selection bias. MATERIALS AND METHODS: From a prospectively collected sarcoma database, 155 primary @entity3 resections were identified (1998-2009); 40 @entity0 underwent successful laparoscopic resection for non-GE junction GIST and were randomly matched (1:1) by @entity1 size (  2.0  cm) to @entity0 with open resection. Clinical and pathologic variables and surgical outcomes were associated with surgery type using conditional logistic regression analyses. RESULTS: The two surgical approaches were comparable for clinical and pathologic variables. Median operating room (OR) time was similar, although median length of stay postsurgery was lower in the laparoscopic versus open group (4 vs. 7  days, P  =  0.002), as was estimated @entity2 (EBL) (25 vs. 100  ml, P  =  0.006). There was no operative mortality, and 30-day morbidity was similar. Oncologic outcomes were also similar with no positive microscopic margins, and 1 recurrence in each group with a median follow-up of 34  months. There were 13 conversions overall, 5 secondary to @entity1 location at the GE junction or lesser curve. CONCLUSIONS: When matched for @entity1 size, laparoscopic resection of primary gastric @entity4  <=8  cm results in shorter hospital stays with similar OR time while maintaining sound oncologic outcomes compared with open resection.

title: Laparoscopic versus open gastric resections for primary XXXX ( @entity4 ): a size-matched comparison.

answer: @entity4


abstract: BACKGROUND: We report six new cases of @entity1 after @entity8 in @entity0 with @entity10 ( @entity10 ) and analyse their clinical and radiological characteristics, together with cases reported in the literature, to deduce the mechanism of @entity3 . METHODS: Six (2%) of 246 @entity0 with @entity10 who were admitted to our hospitals between 1993 and 2009 suffered @entity3 after @entity5 . Ten @entity0 identified in the literature with the PubMed search engine were also included in this study. All the @entity2 in these 16 @entity0 were analysed according to their location, size, and number and were compared according to the spatial relationship between the @entity4 and @entity7 , as follows: (1) anterior vs posterior involvement, (2) cortical vs subcortical involvement, (3) watershed vs non-watershed @entity7 , (4) small vs large @entity7 , (5) single vs multiple @entity7 , and (6) adjacent vs distant involvement. RESULTS: Acute synchronous multiple brain @entity7 occurred in six (38%) @entity0 and recurrent @entity7 in three @entity0 (19%). @entity3 had mainly cortical (72%), anterior (66%), and distant involvement (75%) and were large (69%) and non-watershed (66%). @entity7 had significantly anterior involvement (P   <   0.05), and distant @entity7 tended to have cortical involvement. Non-watershed @entity7 had significantly cortical involvement (P   <   0.05). @entity7 tended to be large. @entity9 was confirmed either pathologically or angiographically in two @entity0 with large @entity3 . CONCLUSIONS: We suggest that @entity6 or @entity9 plays a crucial role in the pathogenesis of @entity3 after acute @entity5 in @entity0 with @entity10 .

title: @entity1 after acute XXXX in @entity0 with @entity10 : six new cases and a short literature review.

answer: @entity5


abstract: BACKGROUND: We report six new cases of @entity1 after @entity8 in @entity0 with @entity10 ( @entity10 ) and analyse their clinical and radiological characteristics, together with cases reported in the literature, to deduce the mechanism of @entity3 . METHODS: Six (2%) of 246 @entity0 with @entity10 who were admitted to our hospitals between 1993 and 2009 suffered @entity3 after @entity5 . Ten @entity0 identified in the literature with the PubMed search engine were also included in this study. All the @entity2 in these 16 @entity0 were analysed according to their location, size, and number and were compared according to the spatial relationship between the @entity4 and @entity7 , as follows: (1) anterior vs posterior involvement, (2) cortical vs subcortical involvement, (3) watershed vs non-watershed @entity7 , (4) small vs large @entity7 , (5) single vs multiple @entity7 , and (6) adjacent vs distant involvement. RESULTS: Acute synchronous multiple brain @entity7 occurred in six (38%) @entity0 and recurrent @entity7 in three @entity0 (19%). @entity3 had mainly cortical (72%), anterior (66%), and distant involvement (75%) and were large (69%) and non-watershed (66%). @entity7 had significantly anterior involvement (P   <   0.05), and distant @entity7 tended to have cortical involvement. Non-watershed @entity7 had significantly cortical involvement (P   <   0.05). @entity7 tended to be large. @entity9 was confirmed either pathologically or angiographically in two @entity0 with large @entity3 . CONCLUSIONS: We suggest that @entity6 or @entity9 plays a crucial role in the pathogenesis of @entity3 after acute @entity5 in @entity0 with @entity10 .

title: @entity1 after acute @entity5 in @entity0 with XXXX : six new cases and a short literature review.

answer: @entity10


abstract: BACKGROUND: We report six new cases of @entity1 after @entity8 in @entity0 with @entity10 ( @entity10 ) and analyse their clinical and radiological characteristics, together with cases reported in the literature, to deduce the mechanism of @entity3 . METHODS: Six (2%) of 246 @entity0 with @entity10 who were admitted to our hospitals between 1993 and 2009 suffered @entity3 after @entity5 . Ten @entity0 identified in the literature with the PubMed search engine were also included in this study. All the @entity2 in these 16 @entity0 were analysed according to their location, size, and number and were compared according to the spatial relationship between the @entity4 and @entity7 , as follows: (1) anterior vs posterior involvement, (2) cortical vs subcortical involvement, (3) watershed vs non-watershed @entity7 , (4) small vs large @entity7 , (5) single vs multiple @entity7 , and (6) adjacent vs distant involvement. RESULTS: Acute synchronous multiple brain @entity7 occurred in six (38%) @entity0 and recurrent @entity7 in three @entity0 (19%). @entity3 had mainly cortical (72%), anterior (66%), and distant involvement (75%) and were large (69%) and non-watershed (66%). @entity7 had significantly anterior involvement (P   <   0.05), and distant @entity7 tended to have cortical involvement. Non-watershed @entity7 had significantly cortical involvement (P   <   0.05). @entity7 tended to be large. @entity9 was confirmed either pathologically or angiographically in two @entity0 with large @entity3 . CONCLUSIONS: We suggest that @entity6 or @entity9 plays a crucial role in the pathogenesis of @entity3 after acute @entity5 in @entity0 with @entity10 .

title: XXXX after acute @entity5 in @entity0 with @entity10 : six new cases and a short literature review.

answer: @entity1


abstract: BACKGROUND: We report six new cases of @entity1 after @entity8 in @entity0 with @entity10 ( @entity10 ) and analyse their clinical and radiological characteristics, together with cases reported in the literature, to deduce the mechanism of @entity3 . METHODS: Six (2%) of 246 @entity0 with @entity10 who were admitted to our hospitals between 1993 and 2009 suffered @entity3 after @entity5 . Ten @entity0 identified in the literature with the PubMed search engine were also included in this study. All the @entity2 in these 16 @entity0 were analysed according to their location, size, and number and were compared according to the spatial relationship between the @entity4 and @entity7 , as follows: (1) anterior vs posterior involvement, (2) cortical vs subcortical involvement, (3) watershed vs non-watershed @entity7 , (4) small vs large @entity7 , (5) single vs multiple @entity7 , and (6) adjacent vs distant involvement. RESULTS: Acute synchronous multiple brain @entity7 occurred in six (38%) @entity0 and recurrent @entity7 in three @entity0 (19%). @entity3 had mainly cortical (72%), anterior (66%), and distant involvement (75%) and were large (69%) and non-watershed (66%). @entity7 had significantly anterior involvement (P   <   0.05), and distant @entity7 tended to have cortical involvement. Non-watershed @entity7 had significantly cortical involvement (P   <   0.05). @entity7 tended to be large. @entity9 was confirmed either pathologically or angiographically in two @entity0 with large @entity3 . CONCLUSIONS: We suggest that @entity6 or @entity9 plays a crucial role in the pathogenesis of @entity3 after acute @entity5 in @entity0 with @entity10 .

title: @entity1 after acute @entity5 in XXXX with @entity10 : six new cases and a short literature review.

answer: @entity0


abstract: BACKGROUND: Lower-limb @entity3 (LLL) is a prevalent complication that is encountered after treatment for gynecological @entity1 . The aim of this study was to evaluate the risk factors for postoperative LLL in @entity0 with @entity1 . METHODS: We conducted a retrospective chart review for @entity0 who had undergone surgery, including systematic lymphadenectomy, for @entity1 . @entity0 who died of @entity1 , were evaluated for short periods of time (<2 years), had missing medical records, or were suffering from @entity2 were excluded. We utilized the International Society of Lymphology staging of @entity3 severity as the diagnostic criteria for LLL, and @entity0 with stage II or III @entity3 , as objectively determined by physicians, were included in the group of @entity0 with LLL. Multivariate analysis was performed to confirm independent risk factors. RESULTS: A total of 155 @entity0 with @entity1 were evaluated. Thirty-one @entity0 (20.0%) contracted LLL with a median follow-up of 6.1 years. Suprafemoral node dissection (odds ratio, 9.5; 95% confidence interval, 1.2-73.3; P = 0.031) and adjuvant radiotherapy (3.7; 1.2-10.9; P = 0.019) were identified as independent risk factors. CONCLUSION: Given that the effectiveness of the above two therapeutic options for @entity1 is currently controversial, the clinical benefits of these therapies should be reevaluated specifically to conserve the quality of life for @entity0 with this disease.

title: Risk factors for lower-limb XXXX after surgery for @entity1 .

answer: @entity3