abstract: OBJECTIVE: To study the association between @entity3 in @entity1 ( @entity1 ) @entity0 and serologic findings, disease activity, and antirheumatic drug treatment, and to study disease activity and reproductive outcomes after a @entity3 . METHODS: Within a nationwide prospective cohort study (Pregnancy-Induced Amelioration of @entity1 study), @entity0 with @entity1 were followed up from preconception until 6 months after delivery or @entity3 . Univariate and logistic regression analyses were performed to assess variables of interest, with covariates included in the models if the P value for association with @entity3 was <0.20 and subsequently excluded if the P value was >0.10. RESULTS: Among 162 pregnancies, 28 @entity3 occurred (17.3%; 95% confidence interval 12.2-24.0%). @entity0 who miscarried were older than @entity0 with an ongoing pregnancy. @entity0 who miscarried tended to be more often positive for anti-citrullinated protein antibodies (ACPAs), to have higher disease activity scores, and to have more often received @entity2 ( @entity4 ) therapy in the past. Logistic regression showed a tendency toward a higher likelihood of @entity3 in association with increasing age (P   =   0.065) and presence of ACPAs (P   =   0.092). After @entity3 , 33% of @entity0 had a flare of @entity1 . Within 1 year, 68% of @entity0 became pregnant again, 14% stopped trying to conceive, and 11% were lost to followup. The live birth rate of the subsequent pregnancy was 90%. CONCLUSION: The @entity3 rate in the @entity5 cohort is comparable to that in the general population. Due to the low frequency of @entity3 in this study, the associations between @entity3 in @entity1 and the presence of ACPAs, disease activity, and @entity4 use did not reach statistical significance. Within 1 year after @entity3 , the majority of @entity0 who continued trying to conceive achieved a pregnancy resulting in a live birth.

title: Brief Report: Miscarriages in Female XXXX @entity0 : Associations With Serologic Findings, Disease Activity, and Antirheumatic Drug Treatment.

answer: @entity1


abstract: OBJECTIVE: To study the association between @entity3 in @entity1 ( @entity1 ) @entity0 and serologic findings, disease activity, and antirheumatic drug treatment, and to study disease activity and reproductive outcomes after a @entity3 . METHODS: Within a nationwide prospective cohort study (Pregnancy-Induced Amelioration of @entity1 study), @entity0 with @entity1 were followed up from preconception until 6 months after delivery or @entity3 . Univariate and logistic regression analyses were performed to assess variables of interest, with covariates included in the models if the P value for association with @entity3 was <0.20 and subsequently excluded if the P value was >0.10. RESULTS: Among 162 pregnancies, 28 @entity3 occurred (17.3%; 95% confidence interval 12.2-24.0%). @entity0 who miscarried were older than @entity0 with an ongoing pregnancy. @entity0 who miscarried tended to be more often positive for anti-citrullinated protein antibodies (ACPAs), to have higher disease activity scores, and to have more often received @entity2 ( @entity4 ) therapy in the past. Logistic regression showed a tendency toward a higher likelihood of @entity3 in association with increasing age (P   =   0.065) and presence of ACPAs (P   =   0.092). After @entity3 , 33% of @entity0 had a flare of @entity1 . Within 1 year, 68% of @entity0 became pregnant again, 14% stopped trying to conceive, and 11% were lost to followup. The live birth rate of the subsequent pregnancy was 90%. CONCLUSION: The @entity3 rate in the @entity5 cohort is comparable to that in the general population. Due to the low frequency of @entity3 in this study, the associations between @entity3 in @entity1 and the presence of ACPAs, disease activity, and @entity4 use did not reach statistical significance. Within 1 year after @entity3 , the majority of @entity0 who continued trying to conceive achieved a pregnancy resulting in a live birth.

title: Brief Report: Miscarriages in Female @entity1 XXXX : Associations With Serologic Findings, Disease Activity, and Antirheumatic Drug Treatment.

answer: @entity0


abstract: STUDY OBJECTIVE: To investigate the rate of @entity2 ( @entity2 ) in a sample of young nulligravid @entity0 and its potential risk factors and consequences on life habits. DESIGN AND @entity0 : The study is based on an online self-administered questionnaire taken by nulligravid @entity0 aged 15 to 25  years. MEASUREMENTS: The Questionnaire for @entity2 and part of The King's Health Questionnaire. Demographics and general characteristics are also recorded. RESULTS: We collected 1936 questionnaires (mean age of @entity0 , 21  years); 12.4% of the sample reported any @entity2 (95% confidence interval [CI] 10.9% to 13.9%). The estimated incidence of @entity2 subtypes was 7.2% (95% CI 6.0% to 8.4%) stress @entity2 , 3.4% (95% CI 2.6% to 4.3%) urge @entity2 , and 1.9% (95% CI 1.3% to 2.6%) mixed @entity2 . Age younger than 19  years and body mass index of 30  kg/m(2) or greater were associated in the multivariate analysis with an increased risk of @entity2 . A self-reported history of @entity1 increased the risk of @entity2 (adjusted odds ratio [AOR] 1.4 and 95% CI 1.1% to 1.9%), without significant differences among the @entity2 subtypes. A current history of constipation (AOR 1.9 and 95% CI 1.3% to 2.6%) and enuresis after the age of 5 also increased the risk of @entity2 (AOR 2.9 and 95% CI 2.0% to 4.3%). CONCLUSION: In a sample of young nulligravid @entity0 , @entity2 was not associated with any chronic risk factor known for elder age, but a prevention program may be proposed to @entity0 because of their young age (eg, educational session to promote the proper functioning of the pelvic floor). More detailed analyses are needed to better assess the prevalence of @entity2 and risk factors in young nulligravid @entity0 .

title: Frequency and Determinants of Urinary Incontinence in Adolescent and Young Nulliparous XXXX .

answer: @entity0


abstract: OBJECTIVE:     To describe our experience with @entity4 ( @entity4 ) for @entity3 and compare the outcomes with @entity4 performed for single masses. @entity0 AND METHODS:     Retrospective analysis of medical records of @entity0 undergoing @entity4 at our institution between 2005 and 2009 was performed.     The cohort was divided in two groups based on @entity1 focality: group 1, @entity4 for a @entity1 (n= 99) and group 2, @entity4 for multiple @entity1 (n= 12).     The groups were compared with regards to demographic and peri-operative variables. RESULTS:     Demographic variables were not different between the groups. Median dominant @entity1 size was 3.1 cm (interquartile range [IQR] 2.4-4.0) and 4.0 cm (2.3-5.9) in groups 1 and 2, respectively.     Median secondary @entity1 size in group 2 was 1.0 cm (1.0-1.8).     Operative times were longer in group 2 compared with group 1 (220 vs 160 min, P= 0.009).     Warm ischaemia times (WIT) (23 vs 22 min) and estimated @entity2 (EBL) (100 vs 85 mL) were similar. CONCLUSIONS:     @entity4 is a viable option for the treatment of multiple @entity3 .     Peri-operative outcomes are similar to standard @entity4 with the exception of longer operative time.     In experienced hands, the advantages of minimally invasive surgery may be extended to select @entity0 with @entity3 .

title: Laparoscopic partial nephrectomy for XXXX : feasibility and analysis of peri-operative outcomes.

answer: @entity1


abstract: We performed exome analysis in two affected siblings with severe @entity3 ( @entity3 ), @entity6 and @entity1 from an Ashkenazi Jewish consanguineous family. We identified only one rare variant, a missense in @entity8 ( @entity9 [ @entity10 ]), that is homozygous in both siblings but not in any of their 11 unaffected siblings or their parents (Logarithm of odds, LOD score: 2.6). This variant is predicted damaging. We genotyped 450 controls of Ashkenazi Jewish ancestry and identified only 5 individuals who are heterozygous for this variant (minor allele frequency: 0.0056). @entity8 ( @entity8 ) encodes a transporter for neutral aminoacids such as @entity5 , @entity2 , @entity0 and @entity4 . @entity7 is essential for neuronal survival and differentiation. Indeed, @entity7 biosynthesis disorders affect brain development and cause severe @entity3 . In the brain, @entity7 is synthesized in astrocytes but not in neurons. It has been proposed that @entity8 mediates the uptake of @entity7 into neurons and the release of glia-borne @entity7 to neighboring cells. @entity8 disruption may thus impair brain development and function by decreasing the levels of @entity7 in neurons. The identification of additional families with mutations in @entity8 would be necessary to confirm its involvement in @entity3 .

title: A homozygous mutation in XXXX in siblings with severe @entity3 and @entity6 .

answer: @entity8


abstract: We performed exome analysis in two affected siblings with severe @entity3 ( @entity3 ), @entity6 and @entity1 from an Ashkenazi Jewish consanguineous family. We identified only one rare variant, a missense in @entity8 ( @entity9 [ @entity10 ]), that is homozygous in both siblings but not in any of their 11 unaffected siblings or their parents (Logarithm of odds, LOD score: 2.6). This variant is predicted damaging. We genotyped 450 controls of Ashkenazi Jewish ancestry and identified only 5 individuals who are heterozygous for this variant (minor allele frequency: 0.0056). @entity8 ( @entity8 ) encodes a transporter for neutral aminoacids such as @entity5 , @entity2 , @entity0 and @entity4 . @entity7 is essential for neuronal survival and differentiation. Indeed, @entity7 biosynthesis disorders affect brain development and cause severe @entity3 . In the brain, @entity7 is synthesized in astrocytes but not in neurons. It has been proposed that @entity8 mediates the uptake of @entity7 into neurons and the release of glia-borne @entity7 to neighboring cells. @entity8 disruption may thus impair brain development and function by decreasing the levels of @entity7 in neurons. The identification of additional families with mutations in @entity8 would be necessary to confirm its involvement in @entity3 .

title: A homozygous mutation in @entity8 in siblings with severe @entity3 and XXXX .

answer: @entity6


abstract: We performed exome analysis in two affected siblings with severe @entity3 ( @entity3 ), @entity6 and @entity1 from an Ashkenazi Jewish consanguineous family. We identified only one rare variant, a missense in @entity8 ( @entity9 [ @entity10 ]), that is homozygous in both siblings but not in any of their 11 unaffected siblings or their parents (Logarithm of odds, LOD score: 2.6). This variant is predicted damaging. We genotyped 450 controls of Ashkenazi Jewish ancestry and identified only 5 individuals who are heterozygous for this variant (minor allele frequency: 0.0056). @entity8 ( @entity8 ) encodes a transporter for neutral aminoacids such as @entity5 , @entity2 , @entity0 and @entity4 . @entity7 is essential for neuronal survival and differentiation. Indeed, @entity7 biosynthesis disorders affect brain development and cause severe @entity3 . In the brain, @entity7 is synthesized in astrocytes but not in neurons. It has been proposed that @entity8 mediates the uptake of @entity7 into neurons and the release of glia-borne @entity7 to neighboring cells. @entity8 disruption may thus impair brain development and function by decreasing the levels of @entity7 in neurons. The identification of additional families with mutations in @entity8 would be necessary to confirm its involvement in @entity3 .

title: A homozygous mutation in @entity8 in siblings with severe XXXX and @entity6 .

answer: @entity3


abstract: INTRODUCTION: Specimens of @entity0 immature permanent teeth after @entity3 ( @entity3 ) are sparse. This case report describes the histologic and immunohistochemical findings of tissue formed in the canal space of a @entity0 immature permanent tooth with @entity1 after @entity3 . METHODS: A @entity0 presenting with immature @entity0 permanent tooth #29  with @entity1 underwent @entity3 . At the 10-month follow-up visit, radiographic examination revealed @entity2 , marked narrowing of the apical foramen, increased thickness of the canal walls, and minimal lengthening of the root. Notably, the tooth regained pulp sensibility. Tooth #29 was extracted for orthodontic reasons and processed for histologic and immunohistochemical examination. RESULTS: The canal space was filled with newly formed cementumlike tissue, bonelike tissue, and fibrous connective tissue. The apical closure, thickness, and length increment of the root were caused by the deposition of cementumlike tissue without dentin. Furthermore, neurons and nerve fibers were observed in the canal space; this observation was confirmed by immunohistochemistry. CONCLUSIONS: Based on the findings in the present case, after @entity3 , the newly formed tissues in the canal space of the @entity0 immature permanent tooth with @entity1 were primarily fibrous connective tissue, cementumlike tissue, and bonelike tissue. Nerve regeneration was identified.

title: Histologic and Immunohistochemical Findings of a @entity0 Immature Permanent Tooth with XXXX after Regenerative Endodontic Treatment.

answer: @entity1


abstract: INTRODUCTION: Specimens of @entity0 immature permanent teeth after @entity3 ( @entity3 ) are sparse. This case report describes the histologic and immunohistochemical findings of tissue formed in the canal space of a @entity0 immature permanent tooth with @entity1 after @entity3 . METHODS: A @entity0 presenting with immature @entity0 permanent tooth #29  with @entity1 underwent @entity3 . At the 10-month follow-up visit, radiographic examination revealed @entity2 , marked narrowing of the apical foramen, increased thickness of the canal walls, and minimal lengthening of the root. Notably, the tooth regained pulp sensibility. Tooth #29 was extracted for orthodontic reasons and processed for histologic and immunohistochemical examination. RESULTS: The canal space was filled with newly formed cementumlike tissue, bonelike tissue, and fibrous connective tissue. The apical closure, thickness, and length increment of the root were caused by the deposition of cementumlike tissue without dentin. Furthermore, neurons and nerve fibers were observed in the canal space; this observation was confirmed by immunohistochemistry. CONCLUSIONS: Based on the findings in the present case, after @entity3 , the newly formed tissues in the canal space of the @entity0 immature permanent tooth with @entity1 were primarily fibrous connective tissue, cementumlike tissue, and bonelike tissue. Nerve regeneration was identified.

title: Histologic and Immunohistochemical Findings of a XXXX Immature Permanent Tooth with @entity1 after Regenerative Endodontic Treatment.

answer: @entity0


abstract: OBJECTIVE: To investigate the effect of @entity1 on functional and social outcomes after mild @entity3 . SETTING: Outpatient @entity3 clinic in a tertiary @entity2 center. @entity0 : A total of 374 mild @entity3 @entity0 were assessed within 3 months of injury and followed up every 3 months for 1 year. DESIGN: Analysis of a historical cohort in a naturalistic clinical setting. MAIN MEASURES: At each visit, symptoms of concussion and @entity4 and indices of functional and social outcomes were measured with the Rivermead Postconcussion Questionnaire, 28-item General Health Questionnaire, and @entity5 Follow-up Questionnaire, respectively. Changes in outcome scores over time were explored using repeated measures analysis of variance and compared between subjects with persistent (SD) and recovered (SR) @entity1 . Predictors of functional/social outcome were determined using linear regression. RESULTS: The percentages of subjects reporting @entity1 at each time point were 71.9%, 57.2%, 55.1%, and 53.7%, respectively. For functional and social outcomes, significant effects of time (F3,315 = 9.54; P < .001), group (SD vs SR) F1,317 = 5.32; P = .022, and time X group interaction F3,315 = 4.14; P = .007 were found. Persistent @entity1 (P = 0.011) and higher symptom burden at 6 months postinjury (P < .0001) were independent predictors of poorer outcome. CONCLUSION: Sleep disturbance, independent of @entity4 , is an important prognostic factor of functional and social outcomes after mild @entity3 .

title: Persistent Sleep Disturbances Independently Predict Poorer Functional and Social Outcomes 1 Year After Mild XXXX .

answer: @entity3


abstract: PURPOSE: @entity3 -reperfusion injury is unavoidable during organ transplantation. Prolonged @entity3 -reperfusion injury is detrimental to short-term and long-term graft function and survival. @entity4 is a recently characterized, endogenously produced gaseous molecule with important physiological roles that has been shown to be cytoprotective during tissue @entity3 -reperfusion injury. The current study aimed to determine whether @entity4 could mitigate cold @entity0 in the clinically relevant context of allogeneic renal transplantation. MATERIALS AND METHODS: Following bilateral native nephrectomy Lewis @entity1 underwent renal transplantation with kidneys from Brown Norway donor @entity1 that were flushed with cold (4C) standard University of Wisconsin preservation solution (University of Wisconsin preservation solution group) or cold University of Wisconsin preservation solution plus 150  M @entity5 ( @entity4 group) solution. Kidneys were stored for 6 hours at 4C in the same solution. Recipient animals were monitored for 14 days or until sacrifice using metabolic cages to assess various parameters of renal graft function. RESULTS: @entity4 treatment improved early allograft survival and function, and decreased early levels of @entity2 , apoptosis and @entity6 compared to University of Wisconsin preservation solution alone. @entity4 treatment did not affect allograft rejection. Rather, it modulated the early allograft transcriptome to decrease the expression of @entity0 , coagulation and cellular stress response genes, and increase the expression of cellular proliferation and Ifn-y induced genes compared to University of Wisconsin preservation solution alone. CONCLUSIONS: To our knowledge our findings are the first to show that @entity4 protects donor kidneys against @entity3 -reperfusion injury in the context of allogeneic renal transplantation. This potentially represents a novel cost-effective therapeutic solution to mitigate @entity3 -reperfusion injury and improve the clinical outcomes of renal transplantation.

title: Hydrogen Sulfide Treatment Mitigates XXXX during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation.

answer: @entity0


abstract: UNASSIGNED: @entity1 levels of therapeutic glycoprotein play an important role in plasma half-life. An undesirable decrease of @entity1 content was observed when we increased Fc-fusion protein productivity fourfold in a GS-CHO cell line by bioprocess optimization. We investigated the potential mechanism for the @entity1 content reduction. We found that limited @entity3 precursor and the extracellular sialidase were not responsible for the reduction of the @entity1 content after titer improvement. Oligosaccharide analysis revealed that the lack of protein galactosylation was the potential cause for the reduction of @entity1 content. Thus we validated this notion by evaluated @entity2 supplementation in 2  L bioreactors. Cell culture performance was not impacted by addition of up to 40  mM @entity2 except for the @entity0 consumption rate. Addition of 20  mM @entity2 to the bioreactor resulted in the increase of 44  % for total @entity1 content and 20.3  % for sialylated glycans. These data were further validated when the process was run on 200  L scaled bioreactor. These data together show that the galactosylation plays an apparent role in sialylation in our current system.

title: XXXX supplementation enhance sialylation of recombinant Fc-fusion protein in CHO cell: an insight into the role of galactosylation in sialylation.

answer: @entity2


abstract: OBJECTIVE: The purpose is to exam whether excess body weight is associated with an increased risk of @entity4 from unnatural causes, particularly, injury. METHOD: We analyzed nationally representative data of 14,453 adults (19 and older) who participated in the third National Health and Nutrition Examination Survey, 1988-1994, and were followed up with vital statuses through December 31, 2006. We used Cox proportional hazard regression to estimate the hazard ratio (HR) of @entity4 from all unnatural causes combined and specific ones. Gray's test was performed to assess the equality of cumulative incidence functions between body mass index (BMI) levels. RESULTS: A total of 128 unnatural deaths were recorded during an 18-year follow-up with 193,019 @entity0 -years accumulated. Compared with healthy weight @entity0 , a @entity0 with excess body weight had a low hazard of @entity4 from unnatural causes [HR=1.00 (reference), 0.58 (0.39-0.87), and 0.50 (0.30-0.82) for healthy weight, overweight and @entity1 @entity0 , respectively]. Injuries, including motor @entity2 and @entity5 , were the major types of unnatural deaths (n=91, 71% of all unnatural deaths), and the risk of @entity4 from @entity3 was linearly and reversely associated with BMI. The @entity3 were 1.00 (reference), 0.57 (0.36-0.91), and 0.36 (0.19-0.69) for healthy weight, overweight and @entity1 @entity0 , respectively. All these estimates were obtained after adjustment of socio-demographic variables. DISCUSSION: Excess body weight appears to be associated with a low risk of @entity4 from unnatural causes, particularly, @entity3 . Additional investigations on the mechanism underlying the relationship between BMI and unnatural deaths are warranted.

title: The relationship between excess body weight and the risk of XXXX from unnatural causes.

answer: @entity4


abstract: BACKGROUND: @entity3 contribute a large share of disease burden in low- and middle-income countries (LMICs). @entity3 have a tendency to occur simultaneously and where there are two or more such conditions, this is termed as 'multimorbidity'. Multimorbidity is associated with adverse health outcomes, but limited research has been undertaken in LMICs. Therefore, this study examines the prevalence and correlates of multimorbidity as well as the associations between multimorbidity and self-rated health, activities of daily living (ADLs), quality of life, and @entity5 across six LMICs. METHODS: Data was obtained from the WHO's Study on global AGEing and adult health ( @entity10 ) @entity11 (2007/10). This was a cross-sectional population based survey performed in LMICs, namely China, Ghana, India, Mexico, Russia, and South Africa, including 42,236 adults aged 18 years and older. Multimorbidity was measured as the simultaneous presence of two or more of eight chronic conditions including @entity8 , @entity7 , @entity6 , @entity9 , @entity0 , @entity2 , @entity1 , and @entity4 . Associations with four health outcomes were examined, namely ADL limitation, self-rated health, @entity5 , and a quality of life index. Random-intercept multilevel regression models were used on pooled data from the six countries. RESULTS: The prevalence of morbidity and multimorbidity was 54.2 % and 21.9 %, respectively, in the pooled sample of six countries. Russia had the highest prevalence of multimorbidity (34.7 %) whereas China had the lowest (20.3 %). The likelihood of multimorbidity was higher in older age groups and was lower in those with higher socioeconomic status. In the pooled sample, the prevalence of 1+ ADL limitation was 14 %, @entity5 5.7 %, self-rated poor health 11.6 %, and mean quality of life score was 54.4. Substantial cross-country variations were seen in the four health outcome measures. The prevalence of 1+ ADL limitation, poor self-rated health, and @entity5 increased whereas quality of life declined markedly with an increase in number of diseases. CONCLUSIONS: Findings highlight the challenge of multimorbidity in LMICs, particularly among the lower socioeconomic groups, and the pressing need for reorientation of health care resources considering the distribution of multimorbidity and its adverse effect on health outcomes.

title: The impact of multimorbidity on adult physical and mental health in low- and middle-income countries: what does the study on global ageing and adult health ( XXXX ) reveal?

answer: @entity10


abstract: UNASSIGNED: @entity3 ( @entity3 )-mediated signaling cascades and gene regulation are mainly involved in diseases such as immunity and @entity1 . In this study microarray analysis was performed using bone marrow-derived macrophages (BMDM) and Raw 264.7 cells to identify novel proteins involved in the @entity3 -mediated cellular response. We found that pleckstrin homology-like domain family, member 1 ( @entity6 ) is a novel gene up-regulated by @entity3 stimulation and determined the unique signaling pathway for its expression. Treatment with @entity3 agonist Pam3 CSK4 increased mRNA, protein, and fluorescence staining of @entity6 . Induction of @entity6 by @entity3 stimulation disappeared from @entity3 KO @entity0 -derived BMDM. Among janus kinase (JAK) family members, @entity5 was involved in @entity3 -stimulated @entity6 expression. @entity4 ( @entity4 ) also participated in @entity6 expression downstream of the @entity5 . Interestingly, @entity2 was an intermediate between @entity5 and @entity4 . In silico analysis revealed the presence of highly conserved y-activated sites within @entity0 @entity6 promoter and confirmed the @entity5 - @entity4 pathway is important to Pam3 CSK4 -induced @entity6 transcription. These findings suggest that the @entity5 - @entity2 - @entity4 pathway is an important signaling pathway for @entity6 expression and that these proteins may play a critical role in eliciting @entity3 -mediated immune and inflammatory response. This article is protected by copyright. All rights reserved.

title: Regulation of XXXX Expression by @entity5 - @entity2 - @entity4 Signaling Pathway.

answer: @entity6


abstract: UNASSIGNED: @entity3 ( @entity3 )-mediated signaling cascades and gene regulation are mainly involved in diseases such as immunity and @entity1 . In this study microarray analysis was performed using bone marrow-derived macrophages (BMDM) and Raw 264.7 cells to identify novel proteins involved in the @entity3 -mediated cellular response. We found that pleckstrin homology-like domain family, member 1 ( @entity6 ) is a novel gene up-regulated by @entity3 stimulation and determined the unique signaling pathway for its expression. Treatment with @entity3 agonist Pam3 CSK4 increased mRNA, protein, and fluorescence staining of @entity6 . Induction of @entity6 by @entity3 stimulation disappeared from @entity3 KO @entity0 -derived BMDM. Among janus kinase (JAK) family members, @entity5 was involved in @entity3 -stimulated @entity6 expression. @entity4 ( @entity4 ) also participated in @entity6 expression downstream of the @entity5 . Interestingly, @entity2 was an intermediate between @entity5 and @entity4 . In silico analysis revealed the presence of highly conserved y-activated sites within @entity0 @entity6 promoter and confirmed the @entity5 - @entity4 pathway is important to Pam3 CSK4 -induced @entity6 transcription. These findings suggest that the @entity5 - @entity2 - @entity4 pathway is an important signaling pathway for @entity6 expression and that these proteins may play a critical role in eliciting @entity3 -mediated immune and inflammatory response. This article is protected by copyright. All rights reserved.

title: Regulation of @entity6 Expression by XXXX - @entity2 - @entity4 Signaling Pathway.

answer: @entity5


abstract: UNASSIGNED: @entity3 ( @entity3 )-mediated signaling cascades and gene regulation are mainly involved in diseases such as immunity and @entity1 . In this study microarray analysis was performed using bone marrow-derived macrophages (BMDM) and Raw 264.7 cells to identify novel proteins involved in the @entity3 -mediated cellular response. We found that pleckstrin homology-like domain family, member 1 ( @entity6 ) is a novel gene up-regulated by @entity3 stimulation and determined the unique signaling pathway for its expression. Treatment with @entity3 agonist Pam3 CSK4 increased mRNA, protein, and fluorescence staining of @entity6 . Induction of @entity6 by @entity3 stimulation disappeared from @entity3 KO @entity0 -derived BMDM. Among janus kinase (JAK) family members, @entity5 was involved in @entity3 -stimulated @entity6 expression. @entity4 ( @entity4 ) also participated in @entity6 expression downstream of the @entity5 . Interestingly, @entity2 was an intermediate between @entity5 and @entity4 . In silico analysis revealed the presence of highly conserved y-activated sites within @entity0 @entity6 promoter and confirmed the @entity5 - @entity4 pathway is important to Pam3 CSK4 -induced @entity6 transcription. These findings suggest that the @entity5 - @entity2 - @entity4 pathway is an important signaling pathway for @entity6 expression and that these proteins may play a critical role in eliciting @entity3 -mediated immune and inflammatory response. This article is protected by copyright. All rights reserved.

title: Regulation of @entity6 Expression by @entity5 - @entity2 - XXXX Signaling Pathway.

answer: @entity4


abstract: UNASSIGNED: @entity3 ( @entity3 )-mediated signaling cascades and gene regulation are mainly involved in diseases such as immunity and @entity1 . In this study microarray analysis was performed using bone marrow-derived macrophages (BMDM) and Raw 264.7 cells to identify novel proteins involved in the @entity3 -mediated cellular response. We found that pleckstrin homology-like domain family, member 1 ( @entity6 ) is a novel gene up-regulated by @entity3 stimulation and determined the unique signaling pathway for its expression. Treatment with @entity3 agonist Pam3 CSK4 increased mRNA, protein, and fluorescence staining of @entity6 . Induction of @entity6 by @entity3 stimulation disappeared from @entity3 KO @entity0 -derived BMDM. Among janus kinase (JAK) family members, @entity5 was involved in @entity3 -stimulated @entity6 expression. @entity4 ( @entity4 ) also participated in @entity6 expression downstream of the @entity5 . Interestingly, @entity2 was an intermediate between @entity5 and @entity4 . In silico analysis revealed the presence of highly conserved y-activated sites within @entity0 @entity6 promoter and confirmed the @entity5 - @entity4 pathway is important to Pam3 CSK4 -induced @entity6 transcription. These findings suggest that the @entity5 - @entity2 - @entity4 pathway is an important signaling pathway for @entity6 expression and that these proteins may play a critical role in eliciting @entity3 -mediated immune and inflammatory response. This article is protected by copyright. All rights reserved.

title: Regulation of @entity6 Expression by @entity5 - XXXX - @entity4 Signaling Pathway.

answer: @entity2


abstract: CONCLUSION: This method is an easy, non-expensive, and effective technique in bilateral @entity3 to improve glottic airway and clinical performance. OBJECTIVE: To evaluate the effectiveness of 'suture arytenoid laterofixation' surgery in bilateral @entity3 . MATERIALS AND METHODS: A retrospective analysis of @entity0 ' medical history undergoing 'suture arytenoid laterofixation' surgery for bilateral @entity3 . This technique was applied under general anesthesia with both microlaryngoscopy and video-monitoring. Two 16 g needles and one 1/0 nylon thread were used for the procedure with 1 cm skin incision; no tracheotomy or tissue excision was required. Pre-post-operative photographs of the glottic region were taken from the endoscopic records, and the areas of rima glottis openings were calculated with the Image-J programme. RESULTS: Forty-seven @entity0 were analyzed. The mean pre-post-operative rima glottis areas were 1.11    0.56 and 2.24    0.93 mm(2), respectively (p < 0.001). Five @entity0 with previous tracheotomy were decannulated within a few days after the operation. In three @entity0 , mild complications developed in the early post-operative period (two @entity1 , one @entity2 ). Tracheotomy was performed to only one pregnant @entity0 in the post-operative first day. None of the @entity0 had granulation formation or @entity4 .

title: Glottic airway gain after 'suture arytenoid laterofixation' in bilateral XXXX .

answer: @entity3


abstract: BACKGROUND: The current standard therapy for @entity0 with @entity5 ( @entity5 ) is rituximab plus @entity3 , @entity2 , @entity4 and @entity1 (RCHOP). The role of radiotherapy (RT) after complete response (CR) to RCHOP in @entity0 with @entity5 remains unclear. This systematic review with a meta-analysis is an attempt to evaluate this role. METHODS: Studies that evaluated RT versus no-RT after CR to RCHOP for @entity5 @entity0 were searched in databases. Hazard ratios (HR) with their respective 95% confidence intervals (CI) were calculated using a random-effects model. RESULTS: A total of 4 qualified retrospective studies (633 @entity0 ) were included in this review. The results suggested that RT improved overall survival (OS; HR 0.33, 95% CI 0.14-0.77) and progression-free/event-free survival (PFS/EFS; HR 0.24, 95% CI 0.11-0.50) in all @entity0 compared with no-RT. In a subgroup analysis of @entity0 with stage III-IV @entity5 , RT improved PFS/EFS (HR 0.19, 95% CI 0.07-0.51) and local control (HR 0.12, 95% CI 0.03-0.44), with a trend of improving OS (HR 0.35, 95% CI 0.12-1.05). CONCLUSION: Consolidation RT could significantly improve outcomes of @entity5 @entity0 who achieved a CR to RCHOP. However, the significance of these results was limited by these retrospective data. Further investigation of the role of consolidation RT in the rituximab era is needed.    2015 S. Karger AG, Basel.

title: The Role of Consolidative Radiotherapy after a Complete Response to Chemotherapy in the Treatment of Diffuse Large XXXX in the Rituximab Era: Results from a Systematic Review with a Meta-Analysis.

answer: @entity5


abstract: OBJECTIVES: In older @entity0 , @entity1 ( @entity1 ) diminishes with age, increasing susceptibility to @entity5 . Evidence has emerged that @entity0 who should have dual x-ray absorptiometry scans to evaluate their bone health are not doing so. Because computed tomography (CT) attenuation has now been correlated with @entity1 thresholds relating to @entity3 , virtually any existing CT scan that includes the L1 vertebra can be used to assess @entity1 . This study evaluates the utility of CT attenuation in characterizing @entity1 in @entity0 after @entity5 . METHODS: The electronic medical records of adults who presented to a level I @entity2 center with @entity4 were evaluated for eligibility. Those with a CT scan of the abdomen or other CT scan with a complete view of the L1 vertebra were included. To measure attenuation, a region of interest was selected to include the body of the L1 vertebra in the axial plane and exclude the cortices and posterior venous complex. RESULTS: Of the 589 @entity0 reviewed, 217 met inclusion criteria; 112 were aged 18 to 64, while 105 were >= 65. Eight (7.1%) @entity0 in the younger cohort had a mean CT attenuation below the 110-HU threshold set for 90% specificity, whereas 31 (29.5%) @entity0 in the older cohort had a mean CT attenuation below this threshold. Using the 160-HU threshold set for 90% sensitivity, 39 (34.8%) @entity0 of the younger cohort and 74 (70%) @entity0 of the older cohort were osteoporotic; all differences in CT attenuation by age were strongly significant (P < .0001). CONCLUSIONS: A significantly larger proportion of older @entity0 with @entity4 had @entity3 , helping validate the utility of CT attenuation in this context. In addition, a large proportion of these @entity0 already had these images available, thus potentially helping limit cost and unnecessary medical investigations.

title: Assessing Bone Mineral Density Following Acute XXXX : The Role of Computed Tomography Attenuation.

answer: @entity4


abstract: BACKGROUND: Leukocyte-poor platelet-rich plasma (LP- @entity9 ) is hypothesized to be more suitable for intra-articular injection than leukocyte-rich @entity9 (LR- @entity9 ) in the treatment of @entity5 . PURPOSE: To compare clinical outcomes and rates of adverse reactions between LP- @entity9 and LR- @entity9 for this application. STUDY DESIGN: Meta-analysis. METHODS: The MEDLINE, EMBASE, and Cochrane databases were reviewed. The primary outcome was the incidence of local adverse reactions. Secondary outcomes were the changes in International Knee Documentation Committee (IKDC) subjective score and Western Ontario and McMaster Universities @entity3 Index (WOMAC) score between baseline and final follow-up measurements. A Bayesian network meta-analysis was performed, with a post hoc meta-regression to correct for baseline differences in WOMAC scores. Treatment rankings were based on surface under the cumulative ranking (SUCRA) probabilities. RESULTS: Included in the analysis were 6 randomized controlled trials (evidence level 1) and 3 prospective comparative studies (evidence level 2) with a total of 1055 @entity0 . Injection of LP- @entity9 resulted in significantly better WOMAC scores than did injection of hyaluronic acid (mean difference, -21.14; 95% CI, -39.63 to -2.65) or placebo (mean difference, -17.84; 95% CI, -34.95 to -0.73). No such difference was observed with LR- @entity9 (mean difference, -14.28; 95% CI, -44.80 to 16.25). All treatment groups resulted in equivalent IKDC subjective scores. The SUCRA analysis showed that LP- @entity9 was the highest ranked treatment for both measures of clinical efficacy (WOMAC and IKDC). Finally, @entity9 injections resulted in a higher incidence of adverse reactions than hyaluronic acid (odds ratio, 5.63; 95% CI, 1.38-22.90), but there was no difference between LR- @entity9 and LP- @entity9 (odds ratio, 0.78; 95% CI, 0.05-11.93). These reactions were nearly always local swelling and @entity2 , with a single study reporting medical side effects including @entity6 , @entity7 , @entity1 , @entity8 , and @entity4 (17/1055 total @entity0 ). CONCLUSION: LP- @entity9 results in improved functional outcome scores compared with hyaluronic acid and placebo when used for treatment of @entity5 . LP- @entity9 and LR- @entity9 have similar safety profiles, although both induce more transient reactions than does hyaluronic acid. Adverse reactions to @entity9 may not be directly related to leukocyte concentration.

title: Effect of Leukocyte Concentration on the Efficacy of Platelet-Rich Plasma in the Treatment of Knee XXXX .

answer: @entity3


abstract: OBJECTIVES: The aim of the present study was to assess differences and correlations between the hippocampal volumes (HCVs), serum @entity4 ( @entity4 ), and @entity3 ( @entity3 ) levels in adolescents with @entity1 ( @entity1 ) compared to healthy controls. METHODS: Using structural magnetic resonance imaging, we compared HCVs of 30 @entity0 with euthymic @entity1 who were already enrolled in a naturalistic clinical follow-up. For comparison, we enrolled 23 healthy controls between the ages of 13 and 19. The boundaries of the hippocampus were outlined manually. The @entity3 and @entity4 serum levels were measured with the sandwich ELISA. RESULTS: The groups did not differ in the right or left HCVs or in the @entity4 or @entity3 serum levels. However, negative correlations were found between the right HCVs and the duration of the disorder and medication and positive correlations were found between the duration of the medications and the @entity4 and @entity3 levels in the @entity0 group. Additionally, positive correlations were found between the follow-up period and left normalized HCVs in both the @entity1 and @entity2 -treated groups. CONCLUSIONS: The right HCVs may vary with illness duration and the medication used to treat @entity1 ; @entity4 and @entity3 levels may be affected by long-term usage. Further research is needed to determine whether these variables and their structural correlates are associated with clinical or functional differences between adolescents with @entity1 and healthy controls.    2015 S. Karger AG, Basel.

title: Decreased right hippocampal volumes and neuroprogression markers in adolescents with XXXX .

answer: @entity1


abstract: BACKGROUND: The use of @entity3 -type stimulants (ATS) places a large burden on health services. OBJECTIVE: The aim was to evaluate the effectiveness of a self-guided Web-based intervention ("breakingtheice") for ATS users over 6 months via a free-to-access site. METHODS: We conducted a randomized trial comparing a waitlist control with a fully automated intervention containing 3 modules derived from cognitive behavioral therapy and motivation enhancement. The main outcome was self-reported ATS use in the past 3 months assessed at 3- and 6-month follow-ups using the @entity1 , Smoking, and Substance Involvement Screening Test (ASSIST). Secondary outcomes were help-seeking intentions (general help-seeking questionnaire), actual help seeking (actual help-seeking questionnaire), @entity2 (Kessler 10), polydrug use (ASSIST), quality of life (European Health Interview Survey), days out of role, and readiness to change. Follow-up data were evaluated using an intention-to-treat (ITT) analysis with a group by time interaction. RESULTS: We randomized 160 @entity0 (intervention: n=81; control: n=79). At 6 months, 38 of 81 (47%) intervention and 41 of 79 (52%) control @entity0 provided data. ATS scores significantly declined for both groups, but the interaction effect was not significant. There were significant ITT time by group interactions for actual help seeking (rate ratio [RR] 2.16; d=0.45) and help-seeking intentions (RR 1.17; d=0.32), with help seeking increasing for the intervention group and declining for the control group. There were also significant interactions for days completely (RR 0.50) and partially (RR 0.74) out of role favoring the intervention group. However, 37% (30/81) of the intervention group did not complete even 1 module. CONCLUSIONS: This self-guided Web-based intervention encouraged help seeking associated with ATS use and reduced days out of role, but it did not reduce ATS use. Thus, this program provides a means of engaging with some sections of a difficult-to-reach group to encourage treatment, but a substantial minority remained disengaged. TRIAL REGISTRATION: Australian and New Zealand Clinical Trials Registry: ACTRN12611000947909; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=343307 (Archived by WebCite at http://www.webcitation.org/6Y0PGGp8q).

title: Six-month outcomes of a Web-based intervention for users of XXXX -type stimulants: randomized controlled trial.

answer: @entity3


abstract: BACKGROUND AND OBJECTIVE: To clinically correlate and evaluate the screening and treatment patterns of @entity1 of @entity3 by a single physician at a tertiary care center between 2002 and 2012. @entity0 AND METHODS: A group of 10,924 newborns screened for @entity4 between 2002 and 2012 were retrospectively analyzed in a consecutive case series. Records of the neonatal intensive care unit (NICU) at Jackson Memorial Hospital/Bascom Palmer Eye Institute were reviewed to identify @entity0 clinically diagnosed with @entity1 of @entity3 who underwent treatment. RESULTS: Laser photocoagulation was used to treat 231 of 10,924 (2.1%). Of these 231 @entity0 , 176 (76.2%) were included in the study (55 @entity0 were excluded because they were referred from outside institutions for advanced @entity4 ). Of the 176 treated @entity0 , 89 (50.6%) were male and 87 (49.4%) were female. The average birth weight was 687.3 g. The mean gestational age was 24.8 weeks. The mean time between birth and treatment was 3 months. Of the 176 @entity0 , 31 required re-treatment with laser photocoagulation. The rates of treatment and retreatment significantly declined with the experience of the treating physician ( P < .01). @entity2 occurred in two of 176 @entity0 (1.1%). CONCLUSION: Experience is essential in delivering optimal care in a complex disease such as @entity4 . Between 2002 and 2012, the rate of treatment and retreatment significantly decreased. Possible reasons include improvements in neonatal care, but it is more likely that the rate of treatment and re-treatment is inversely proportional to the ophthalmologist's experience with and comfort in managing @entity4 .

title: Changing Treatment Patterns of XXXX at a Tertiary Medical Center Between 2002 and 2012.

answer: @entity4


abstract: PURPOSE: @entity5 ( @entity5 ) autoantibodies (TPOAb) seem to be protective for @entity1 with @entity0 ( @entity0 ). Thyroid and breast tissues both express the @entity7 symporter ( @entity9 ), similarly both have a peroxidase activity, @entity5 and lactoperoxidase ( @entity8 ) respectively. We hypothesize a common immune response to a thyroid/breast shared antigen suggesting three putative mechanisms: (1) TPOAb react to both @entity5 and @entity8 , (2) @entity5 could be expressed in @entity0 and (3) @entity1 with TPOAb could have autoantibodies to @entity9 (NISAb). Previous studies excluded NISAb that block @entity9 activity in sera of @entity1 with @entity4 ( @entity4 ) and/or @entity0 . This study investigates neutral NISAb (binding without affecting function). METHODS: Clones of @entity2 cells stably expressing @entity1 @entity9 ( @entity9 ; @entity2 - @entity9 ) were isolated following transfection of @entity9 in pcDNA3 vector. Expression of @entity9 mRNA and surface protein was confirmed by PCR and flow cytometry respectively using a @entity9 -mouse-monoclonal-antibody. @entity2 - @entity9 and controls transfected with the empty pcDNA3 vector ( @entity2 -Empty) were incubated with 42 heat-inactivated @entity1 sera followed by an anti-human-IgG- @entity6 -conjugate: 12 with @entity0 , 11 with @entity4 , 10 with both @entity0 and @entity4 and 9 with non-autoimmune @entity3 . The Kolmogorov-Smirnov Test was used to compare the fluorescence intensity obtained with @entity2 - @entity9 and @entity2 -Empty, using sera from six young males as a negative control population. RESULTS: None of the 42 sera were positive for NISAb. CONCLUSIONS: NISAb are rare and @entity9 is unlikely to be a common thyroid/ @entity0 shared antigen. We have recently demonstrated @entity5 expression in @entity0 tissue and are currently investigating TPOAb cross-reactivity with @entity5 / @entity8 .

title: The XXXX symporter is unlikely to be a thyroid/breast shared antigen.

answer: @entity7


abstract: Pregnant @entity0 were injected with 0, 6 or 10 mg/kg of @entity3 on Days 6-9 of gestation. Dams given the 10 mg/kg dose failed to deliver young or produced stillborn. External morphology was normal for @entity0 given either the 0 or 6 mg/kg dose. Whole brains were examined from male and female @entity0 , 21 or 90 days old. External brain dimensions were measured with calipers. Brains were sectioned at three criterion locations. A microprojector was used to project brain sections in order to measure intrastructural distances. Sections were examined with a light microscope to look for abnormalities. Various expected age-related changes were noted showing the sensitivity of the anatomical methods. @entity4 produced @entity2 , decreased thickness of cerebral cortex in the parietal section and increased thickness of hippocampus in the occipital section. With these exceptions, the brains of @entity1 -treated @entity0 showed normal development.

title: Effects of the high XXXX dose used in the collaborative behavioral teratology study on brain anatomy.

answer: @entity4


abstract: OBJECTIVE: To describe the cross-cultural adaptation of the Affective Reactivity Index (ARI) to Brazilian Portuguese and to investigate preliminary psychometric properties of the adapted version. METHODS: Cross-cultural adaptation was based on the investigation of the theoretical and operational equivalences of the original ARI in the Brazilian context, followed by a process of translation, back-translation, and review by a committee of experts. Data analysis was carried out in a community sample of 133 schoolchildren aged 8 to 17 years to investigate the following characteristics of the ARI: 1) factor structure; 2) internal consistency; 3) construct validity comparing differential relationships between @entity0 and @entity1 ; and 4) item response theory (IRT) parameters. RESULTS: A final Brazilian Portuguese version of the instrument was defined and is presented. Internal consistency was good, and our analysis supported the original single-factor structure of the ARI. Correlations of the ARI with distress-related @entity1 dimensions were higher than with phobic-related @entity1 dimensions, supporting its construct validity. In addition, higher ARI scores were associated with higher @entity0 . IRT analysis underscored frequency of loss of temper as essential to inform about pathological states of @entity0 . CONCLUSION: The Brazilian Portuguese version of the ARI seems to be very similar to the original instrument in terms of conceptual, item, semantic, and operational equivalence. Our preliminary analysis replicates and extends previous evidence confirming promising psychometric properties for the ARI.

title: Cross-cultural adaptation and preliminary psychometric properties of the Affective Reactivity Index in Brazilian Youth: implications for DSM-5 measured XXXX .

answer: @entity0


abstract: @entity1 grain yield is predicted to decrease in the future because of an increase in tropospheric ozone concentration. However, the underlying mechanisms are unclear. Here, we investigated the responses to ozone of two @entity1 ( @entity1 .) cultivars, Sasanishiki and Habataki. Sasanishiki showed ozone-induced @entity0 , but no grain yield loss. By contrast, Habataki showed grain yield loss with minimal @entity0 . A QTL associated with grain yield loss caused by ozone was identified in Sasanishiki/Habataki chromosome segment substitution lines and included the ABERRANT PANICLE ORGANIZATION 1 (APO1) gene. The Habataki allele of the APO1 locus in a near-isogenic line also resulted in grain yield loss upon ozone exposure, suggesting APO1 involvement in ozone-induced yield loss. Only a few differences in the APO1 amino acid sequences were detected between the cultivars, but the APO1 transcript level was oppositely regulated by ozone exposure: i.e., it increased in Sasanishiki and decreased in Habataki. Interestingly, the levels of some phytohormones (jasmonic acid, jasmonoyl-L-isoleucine, and abscisic acid) known to be involved in attenuation of ozone-induced @entity0 tended to decrease in Sasanishiki but to increase in Habataki upon ozone exposure. These data indicate that ozone-induced grain yield loss in Habataki is caused by a reduction in the APO1 transcript level through an increase in the levels of phytohormones that reduce leaf damage.

title: Ozone-Induced XXXX Grain Yield Loss Is Triggered via a Change in Panicle Morphology That Is Controlled by ABERRANT PANICLE ORGANIZATION 1 Gene.

answer: @entity1


abstract: UNASSIGNED: The aim of this study was to investigate the prognosis associated with @entity5 ( @entity5 ) depending on location, time of appearance, and duration in @entity0 with @entity2 ( @entity2 ). From January 1998 to January 2008, we recruited 5,570 @entity0 with @entity2 . Thirty-day and 7-year all-cause mortality, according to @entity5 location, time of appearance, and duration were analyzed by multivariable analyses. @entity5 was present in 964 @entity0 (17.3%); @entity4 ( @entity6 ) 10.6% and @entity6 ( @entity6 ) 6.7%. Overall mortality rate at 30 days was 13.2% (n  = 738) and 7 years was 6.34 deaths per 100 @entity0 -year. Both @entity6 and @entity6 were more frequently previous, 42.9% and 58.8%. Compared with non- @entity5 , all @entity5 groups showed higher prevalence of co-morbidities, especially rates of @entity1 (49.0% vs 34.3%, p <0.001) and more often @entity3 during hospitalization (54.5% vs 26.6%, p <0.001). Compared with @entity6 , @entity0 with @entity6 had a higher prevalence of co-morbidities and a higher mortality, especially the new @entity5 , 30 days: 52.5% versus 31.6% and 7 years (incident rate): 27.2 versus 13.3 per 100 @entity0 -year. New transient @entity5 had lower @entity3 on admission (42.6% vs 58.3%, p  = 0.008) and 30-day mortality (20.3% vs 69.6%, p <0.001) compared with permanent in both locations. New permanent @entity6 was independently associated with 30-day (hazard ratio [HR] 2.01, 95% confidence interval [CI] 1.45 to 2.79) and 7-year mortality (HR 3.12, 95% CI 2.38 to 4.09). New-permanent @entity6 was independently associated with 30-day (HR 2.15, 95% CI 1.47 to 3.15) and 7-year mortality (HR 2.91, 95% CI 2.08 to 4.08). In conclusion, in @entity0 with @entity2 , the appearance of a new @entity5 was independently associated with a higher 30-day and 7-year all-cause mortality.

title: Relation of New Permanent Right or Left Bundle Branch Block on Short- and Long-Term Mortality in Acute XXXX Bundle Branch Block and  @entity2 .

answer: @entity2


abstract: UNASSIGNED: The aim of this study was to investigate the prognosis associated with @entity5 ( @entity5 ) depending on location, time of appearance, and duration in @entity0 with @entity2 ( @entity2 ). From January 1998 to January 2008, we recruited 5,570 @entity0 with @entity2 . Thirty-day and 7-year all-cause mortality, according to @entity5 location, time of appearance, and duration were analyzed by multivariable analyses. @entity5 was present in 964 @entity0 (17.3%); @entity4 ( @entity6 ) 10.6% and @entity6 ( @entity6 ) 6.7%. Overall mortality rate at 30 days was 13.2% (n  = 738) and 7 years was 6.34 deaths per 100 @entity0 -year. Both @entity6 and @entity6 were more frequently previous, 42.9% and 58.8%. Compared with non- @entity5 , all @entity5 groups showed higher prevalence of co-morbidities, especially rates of @entity1 (49.0% vs 34.3%, p <0.001) and more often @entity3 during hospitalization (54.5% vs 26.6%, p <0.001). Compared with @entity6 , @entity0 with @entity6 had a higher prevalence of co-morbidities and a higher mortality, especially the new @entity5 , 30 days: 52.5% versus 31.6% and 7 years (incident rate): 27.2 versus 13.3 per 100 @entity0 -year. New transient @entity5 had lower @entity3 on admission (42.6% vs 58.3%, p  = 0.008) and 30-day mortality (20.3% vs 69.6%, p <0.001) compared with permanent in both locations. New permanent @entity6 was independently associated with 30-day (hazard ratio [HR] 2.01, 95% confidence interval [CI] 1.45 to 2.79) and 7-year mortality (HR 3.12, 95% CI 2.38 to 4.09). New-permanent @entity6 was independently associated with 30-day (HR 2.15, 95% CI 1.47 to 3.15) and 7-year mortality (HR 2.91, 95% CI 2.08 to 4.08). In conclusion, in @entity0 with @entity2 , the appearance of a new @entity5 was independently associated with a higher 30-day and 7-year all-cause mortality.

title: Relation of New Permanent Right or Left Bundle Branch Block on Short- and Long-Term Mortality in Acute @entity2 Bundle Branch Block and  XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity0 flocks have experienced @entity0 @entity2 sporadically in the United States since the 1990s. Twenty-four field isolates of @entity4 (TCoV) from multiple states in the United States were recovered from 1994 to 2010 to determine the genetic relationships among them. The entire spike (S) gene of each TCoV isolate was amplified and sequenced. Pairwise comparisons were performed using the Clustal W program, revealing 90.0  % to 98.4  % sequence identity in the full-length S protein, 77.6  % to 96.6  % in the @entity1 terminus of the S1 subunit (containing one hypervariable region in S1a), and 92.1  % to 99.3  % in the S2 subunit at the deduced @entity3 sequence level. The conserved motifs, including two cleavage recognition sequences of the S protein, two heptad repeats, the transmembrane domain, and the Golgi retention signal were identified in all TCoV isolates. Phylogenetic analysis based on the full-length S gene was used to distinguish North American TCoV isolates from French TCoV isolates. Among the North American TCoV isolates, three distinct genetic groups with 100  % bootstrap support were observed. North Carolina isolates formed group I, Texas isolates formed group II, and Minnesota isolates formed Group III. The S genes of 24 TCoV isolates from the United States remained conserved because they contained predominantly synonymous substitutions. The findings of the present study suggest endemic circulation of distinct TCoV genotypes in different geographic locations.

title: Genotyping of XXXX field isolates from various geographic locations in the Unites States based on the spike gene.

answer: @entity4


abstract: UNASSIGNED: The vertebrate gene family for neuropeptide Y ( @entity2 ) receptors expanded by duplication of the chromosome carrying the ancestral Y1-Y2-Y5 gene triplet. After loss of some duplicates, the ancestral jawed vertebrate had seven receptor subtypes forming the Y1 (including Y1, Y4, Y6, Y8), Y2 (including Y2, Y7) and Y5 (only Y5) subfamilies. Lampreys are considered to have experienced the same chromosome duplications as gnathostomes and should also be expected to have multiple receptor genes. However, previously only a Y4-like and a Y5 receptor have been cloned and characterized. Here we report the cloning and characterization of two additional receptors from the @entity4 @entity4 . Sequence phylogeny alone could not with certainty assign their identity, but based on synteny comparisons of @entity5 and the Arctic lamprey, Lethenteron camtschaticum, with jawed vertebrates, the two receptors most likely are Y1 and Y2. Both receptors were expressed in @entity0 HEK293 cells and @entity3 assays were performed to determine the response to the three native lamprey peptides @entity2 , @entity1 and PMY. The three peptides have similar potencies in the nanomolar range for Y1. No obvious response to the three peptides was detected for Y2. Synteny analysis supports identification of the previously cloned receptor as Y4. No additional @entity2 receptor genes could be identified in the presently available lamprey genome assemblies. Thus, four @entity2 -family receptors have been identified in lampreys, orthologs of the same subtypes as in @entity0 ( @entity6 ), whereas many other vertebrate lineages have retained additional ancestral subtypes.

title: Neuropeptide Y family receptors Y1 and Y2 from XXXX , @entity4 .

answer: @entity4


abstract: UNASSIGNED: The vertebrate gene family for neuropeptide Y ( @entity2 ) receptors expanded by duplication of the chromosome carrying the ancestral Y1-Y2-Y5 gene triplet. After loss of some duplicates, the ancestral jawed vertebrate had seven receptor subtypes forming the Y1 (including Y1, Y4, Y6, Y8), Y2 (including Y2, Y7) and Y5 (only Y5) subfamilies. Lampreys are considered to have experienced the same chromosome duplications as gnathostomes and should also be expected to have multiple receptor genes. However, previously only a Y4-like and a Y5 receptor have been cloned and characterized. Here we report the cloning and characterization of two additional receptors from the @entity4 @entity4 . Sequence phylogeny alone could not with certainty assign their identity, but based on synteny comparisons of @entity5 and the Arctic lamprey, Lethenteron camtschaticum, with jawed vertebrates, the two receptors most likely are Y1 and Y2. Both receptors were expressed in @entity0 HEK293 cells and @entity3 assays were performed to determine the response to the three native lamprey peptides @entity2 , @entity1 and PMY. The three peptides have similar potencies in the nanomolar range for Y1. No obvious response to the three peptides was detected for Y2. Synteny analysis supports identification of the previously cloned receptor as Y4. No additional @entity2 receptor genes could be identified in the presently available lamprey genome assemblies. Thus, four @entity2 -family receptors have been identified in lampreys, orthologs of the same subtypes as in @entity0 ( @entity6 ), whereas many other vertebrate lineages have retained additional ancestral subtypes.

title: Neuropeptide Y family receptors Y1 and Y2 from @entity4 , XXXX .

answer: @entity4


abstract: UNASSIGNED: The objective of this study was to determine the relationship between citrullinated proteins in synovial tissue with peripheral anti-citrullinated peptides autoantibodies (ACPA) and peptidylarginine deiminase (PADI) @entity5 , @entity6 , and @entity4 messenger RNA (mRNA) expressions in synovial tissue and fibroblast-like synoviocytes in @entity1 ( @entity1 ) @entity0 . Eleven @entity1 and 12 @entity2 ( @entity2 ) @entity0 who underwent knee replacement surgery were studied. We detected citrullinated proteins in synovial tissue homogenates by western blot and serum ACPA by ELISA to anti-cyclic citrullinated peptide (anti- @entity3 ) antibodies, and @entity5 , @entity6 , and @entity4 mRNA expressions in synovial tissue and in fibroblast-like synoviocytes. @entity0 with high amount of citrullinated proteins in synovial tissue (3 out of 7) have high levels of anti- @entity3 in serum. However, in the remaining 4 @entity0 , the amount of synovial citrullinated proteins was minimal and their sera showed low levels of anti- @entity3 antibodies. Furthermore, we observed an increase in @entity5 mRNA expression in @entity1 synovial tissue compared with @entity2 @entity0 (p   =   0.02). We detected @entity6 mRNA in the synovial tissue of @entity1 @entity0 , but not in the tissue of @entity2 @entity0 . Even though fibroblast-type synoviocytes in @entity1 are not the main source of PADs in the synovial tissue, they express @entity5 mRNA moderately, @entity4 mRNA weakly, while there is no detectable expression of @entity6 mRNA. In conclusion, we found a variety of citrullinated proteins in the synovial tissue of @entity1 @entity0 and the amount of such proteins is related to serum concentration of anti- @entity3 antibodies. We identified the presence of  @entity6 mRNA expression in synovial tissue and @entity5 and @entity4 mRNA expressions in fibroblast-like synoviocytes from @entity0 with @entity1 .

title: The amount of citrullinated proteins in synovial tissue is related to serum anti-cyclic citrullinated peptide (anti- XXXX ) antibody levels.

answer: @entity3


abstract: BACKGROUND AND AIMS: Classical features of @entity4 ( @entity8 ) may be altered during the abrupt onset of the disease. @entity3 therapy can be life-saving, but its use in the fulminant presentation of @entity8 ( @entity8 ) remains controversial. We aimed to assess the clinical features of @entity0 with @entity8 and to describe the role of corticosteroids in this population. @entity0 AND METHODS: We retrospectively analyzed 154 adult @entity0 with @entity5 who were admitted to six liver transplantation (LT) programs. The @entity8 simplified criteria were used to identify @entity0 with @entity8 . RESULTS: We identified 40 (26%) @entity0 with @entity8 . Compared with other etiologies, @entity0 with @entity8 presented a longer interval from @entity6 to @entity1 (26 vs. 16 days, P=0.02) and a lower @entity7 ( @entity7 ) score on admission (29 vs. 33, P=0.002). Overall, 25 (62%) @entity0 with @entity8 underwent LT, eight (20%) @entity0 survived, and seven (18%) died without LT. Seventeen @entity0 received corticosteroids therapy, of whom seven (41%) survived without LT. Among the treated @entity0 , higher @entity7 score and @entity1 grade of 3 or more were associated significantly with @entity2 . CONCLUSION: @entity0 with @entity8 have a more indolent presentation compared with the non- @entity8 population. Altogether, only eight (20%) @entity0 presenting with @entity8 survived without LT. A subset of @entity0 with @entity8 and an initial @entity7 score less than 27 and low-grade hepatic @entity1 might benefit from administration of corticosteroids.

title: Fulminant presentation of XXXX : clinical features and early predictors of corticosteroid treatment failure.

answer: @entity4


abstract: AIMS: The study aims to develop a novel multistep chromatographic purification process for @entity0 enterovirus71 virus-like particles (VLPs) produced from insect cells (Sf9) infected with recombinant baculovirus. METHODS AND RESULTS: Sf9 cells were maintained in the Wave Bioreactor system 20/50, and harvested when the viability decreased to 75% after infected with Bac-P1-3CD at the multiplicity of @entity2 (MOI) of 1. After sonication and centrifugation, EV71 VLPs were purified with Capto(   ) Core 700, Capto(   ) adhere and Capto(   ) @entity4 . The purity was then determined by SDS-PAGE, Western blotting and high-performance liquid chromatography (HPLC), while the diameter of purified EV71 VLPs was analysed by Dynamic Light Scattering (DLS) and Transmission electron microscopy (TEM). Immunization of BALB/c mice and serum collection were performed after contamination analysis, and neutralization antibodies were then analysed by pseudovirus-based microneutralization assay. Results showed that these purified EV71 VLPs can be successfully purified with ~31  52% yield and >95% purity. They could elicit stronger neutralization antibodies in @entity1 compared with those produced from @entity3 -inactivated EV71 virus. CONCLUSIONS: Our results demonstrated that EV71 VLPs can be purified with the multistep chromatographic protocol. SIGNIFICANCE AND IMPACT OF THE STUDY: This work presents a novel multistep chromatographic technique, an effective way of purifying EV71 VLPs with high purity. This purification process can thus serve as foundation for further development of industrial-scale production process of EV71 VLP vaccine candidates.

title: Enterovirus71 virus-like particles produced from insect cells and purified by multistep chromatography elicit strong humoral immune responses in XXXX .

answer: @entity1


abstract: The study aimed to investigate whether we can stop antibiotic therapy when signs and symptoms have resolved in @entity1 ( @entity1 ) @entity0 with different grades of @entity4 ( @entity4 ) and those without @entity4 , and to determine whether the severity of @entity4 and @entity3 has an effect on antibiotic therapy duration. A prospective randomized controlled trial of @entity1 @entity0 was carried out. @entity0 were randomized into 2 groups when signs and symptoms had resolved: continuing antibiotics group (CAG) and discontinuing antibiotics group (DAG). The recurrence and clinical outcomes were recorded. The recurrence rate of mild @entity3 with mild/moderate @entity4 was similar in the 2 groups. Compared with CAG, the recurrence rate of mild @entity3 with severe @entity4 was higher in DAG (P = .030), also for moderate/severe @entity3 with @entity4 (mild/moderate [P = .032]; severe [P = .008]). No difference was found in the 2 groups (either mild or moderate/severe) for those without @entity4 . The clinical outcomes of mild @entity3 in @entity0 were similar in the 2 groups. For moderate/severe @entity3 , the healing rate was higher (73.3% vs 48.3%), and the rate of minor/major amputation and @entity2 was lower (23.8% vs 49.4%; 6.9% vs 20.7%; 2.0% vs 13.8%) in the CAG. When the clinical signs and symptoms of @entity3 have resolved, it might be appropriate to stop antibiotics for @entity1 @entity0 without @entity4 , and also for @entity0 with mild @entity3 with mild/moderate @entity4 . For @entity0 with mild @entity3 with severe @entity4 and moderate/severe @entity3 with @entity4 , we should perhaps continue antibiotic treatment. Continuing antibiotic therapy could improve clinical outcomes for @entity0 with moderate/severe @entity3 .

title: Can We Stop Antibiotic Therapy When Signs and Symptoms Have Resolved in XXXX @entity0 ?

answer: @entity1


abstract: The study aimed to investigate whether we can stop antibiotic therapy when signs and symptoms have resolved in @entity1 ( @entity1 ) @entity0 with different grades of @entity4 ( @entity4 ) and those without @entity4 , and to determine whether the severity of @entity4 and @entity3 has an effect on antibiotic therapy duration. A prospective randomized controlled trial of @entity1 @entity0 was carried out. @entity0 were randomized into 2 groups when signs and symptoms had resolved: continuing antibiotics group (CAG) and discontinuing antibiotics group (DAG). The recurrence and clinical outcomes were recorded. The recurrence rate of mild @entity3 with mild/moderate @entity4 was similar in the 2 groups. Compared with CAG, the recurrence rate of mild @entity3 with severe @entity4 was higher in DAG (P = .030), also for moderate/severe @entity3 with @entity4 (mild/moderate [P = .032]; severe [P = .008]). No difference was found in the 2 groups (either mild or moderate/severe) for those without @entity4 . The clinical outcomes of mild @entity3 in @entity0 were similar in the 2 groups. For moderate/severe @entity3 , the healing rate was higher (73.3% vs 48.3%), and the rate of minor/major amputation and @entity2 was lower (23.8% vs 49.4%; 6.9% vs 20.7%; 2.0% vs 13.8%) in the CAG. When the clinical signs and symptoms of @entity3 have resolved, it might be appropriate to stop antibiotics for @entity1 @entity0 without @entity4 , and also for @entity0 with mild @entity3 with mild/moderate @entity4 . For @entity0 with mild @entity3 with severe @entity4 and moderate/severe @entity3 with @entity4 , we should perhaps continue antibiotic treatment. Continuing antibiotic therapy could improve clinical outcomes for @entity0 with moderate/severe @entity3 .

title: Can We Stop Antibiotic Therapy When Signs and Symptoms Have Resolved in @entity1 XXXX ?

answer: @entity0


abstract: OBJECTIVE: To review and synthesize the evidence on the use of @entity3 -PET in the assessment and treatment of nine types of @entity1 with respect to the following clinical situations: diagnosis, @entity1 , restaging, and monitoring response to treatment. DATA SOURCES: Comprehensive searches were conducted in four relevant electronic databases for the time period from 2003 to March 2008. REVIEW METHODS: Studies should be published in English, with more than 12 adult @entity0 with primary @entity1 of the following type: bladder, brain, cervical, kidney, ovarian, pancreatic, prostate, small cell lung, and testicular. Restrictions regarding study design were not imposed. Two independent reviewers assessed study relevance, extracted the data and assessed the methodological quality of the studies. A combination of qualitative and quantitative approaches was used to synthesize the data. RESULTS: One hundred and nine articles were included in this report. The strongest evidence for the diagnostic accuracy of @entity3 -PET or @entity3 -PET/CT has been produced for @entity1 of locally advanced cervical @entity1 and the detection and restaging of recurrent disease, the detection of @entity2 recurrences following treatment, and the diagnosing and initial @entity1 of @entity4 . These and other indications require further research to show the impact of @entity3 -PET or @entity3 -PET/CT on @entity0 management or added value in the diagnostic and therapeutic process. CONCLUSION: For some type of @entity1 (e.g., cervical, ovarian, and @entity4 ), there is some evidence of the utility of @entity3 -PET or @entity3 -PET/CT for diagnosing, @entity1 , or detecting recurrences, but they may still require more studies to augment the evidence base. Further studies are needed to reach firm conclusions about the clinical effectiveness of @entity3 -PET and @entity3 -PET/CT in terms of the impact on diagnosis and treatment options, @entity0 -centered outcomes, and economic costs. It is still unclear how @entity3 -PET and @entity3 -PET/CT affects @entity0 treatment and ultimately their outcome. For other types of @entity1 examined in the review (e.g., bladder, kidney, prostate, @entity5 , and testicular) the answers are still inconclusive and require more careful study.

title: Positron Emission Tomography for Nine XXXX (Bladder, Brain, Cervical, Kidney, Ovarian, Pancreatic, Prostate, Small Cell Lung, Testicular)

answer: @entity1


abstract: OBJECTIVE: To investigate nonpermanent inferior vena cava (IVC) filter in the prevention of perioperative @entity4 ( @entity4 ) in @entity0 of @entity1 with @entity3 ( @entity3 ). METHODS: Lower extremity or pelvic @entity1 @entity0 with lower extremity @entity3 hospitalized in our hospital from January 2003 to October 2014 were retrospectively analyzed. Data was analyzed for age, gender, position of @entity1 , position of proximal of @entity2 , indications of placement, complications, retrieval rate, and rate of entrapped filter clot. @entity0 who underwent IVC filter placement were selected as the filter group. The @entity0 who did not perform IVC filter placement after 2008 and the cases between January 2003 and December 2007 were selected as control group 1 and control group 2, respectively. The incidence of perioperative symptomatic @entity4 and mortality were analyzed. RESULTS: A total of 2763 cases complicated with @entity3 underwent orthopedic surgery between January 2003 and October 2014. 823 nonpermanent filters were inserted. All filters were successfully deployed with no major complications. After a mean 14.2 days indwelling time, all of temporary filters were removed. Retrieval was attempted in 556 @entity0 with retrievable filters and was successful in 545 (98%); mean indwelling time was 16.3 days. The total retrieval rate was 90%. The incidence of @entity4 in the filter group was significantly lower compared with the two control groups. Among the @entity0 who received chemical anticoagulant therapy, the incidence of @entity4 in filter group, control group 1 and control group 2 were 0.14%, 1.60% and 2.10%, respectively. The incidence of @entity4 in filter group was also significant lower compared with control groups. CONCLUSION: Nonpermanent IVC filter placement seems like to be a safe and effective method for preventing perioperative symptomatic and fatal @entity4 in @entity1 @entity0 with @entity3 in the present retrospective study.

title: Evaluation of nonpermanent inferior vena cava filter placement in @entity0 with @entity3 after XXXX : A single-center retrospective study.

answer: @entity1


abstract: OBJECTIVE: To investigate nonpermanent inferior vena cava (IVC) filter in the prevention of perioperative @entity4 ( @entity4 ) in @entity0 of @entity1 with @entity3 ( @entity3 ). METHODS: Lower extremity or pelvic @entity1 @entity0 with lower extremity @entity3 hospitalized in our hospital from January 2003 to October 2014 were retrospectively analyzed. Data was analyzed for age, gender, position of @entity1 , position of proximal of @entity2 , indications of placement, complications, retrieval rate, and rate of entrapped filter clot. @entity0 who underwent IVC filter placement were selected as the filter group. The @entity0 who did not perform IVC filter placement after 2008 and the cases between January 2003 and December 2007 were selected as control group 1 and control group 2, respectively. The incidence of perioperative symptomatic @entity4 and mortality were analyzed. RESULTS: A total of 2763 cases complicated with @entity3 underwent orthopedic surgery between January 2003 and October 2014. 823 nonpermanent filters were inserted. All filters were successfully deployed with no major complications. After a mean 14.2 days indwelling time, all of temporary filters were removed. Retrieval was attempted in 556 @entity0 with retrievable filters and was successful in 545 (98%); mean indwelling time was 16.3 days. The total retrieval rate was 90%. The incidence of @entity4 in the filter group was significantly lower compared with the two control groups. Among the @entity0 who received chemical anticoagulant therapy, the incidence of @entity4 in filter group, control group 1 and control group 2 were 0.14%, 1.60% and 2.10%, respectively. The incidence of @entity4 in filter group was also significant lower compared with control groups. CONCLUSION: Nonpermanent IVC filter placement seems like to be a safe and effective method for preventing perioperative symptomatic and fatal @entity4 in @entity1 @entity0 with @entity3 in the present retrospective study.

title: Evaluation of nonpermanent inferior vena cava filter placement in @entity0 with XXXX after @entity1 : A single-center retrospective study.

answer: @entity3


abstract: OBJECTIVE: To investigate nonpermanent inferior vena cava (IVC) filter in the prevention of perioperative @entity4 ( @entity4 ) in @entity0 of @entity1 with @entity3 ( @entity3 ). METHODS: Lower extremity or pelvic @entity1 @entity0 with lower extremity @entity3 hospitalized in our hospital from January 2003 to October 2014 were retrospectively analyzed. Data was analyzed for age, gender, position of @entity1 , position of proximal of @entity2 , indications of placement, complications, retrieval rate, and rate of entrapped filter clot. @entity0 who underwent IVC filter placement were selected as the filter group. The @entity0 who did not perform IVC filter placement after 2008 and the cases between January 2003 and December 2007 were selected as control group 1 and control group 2, respectively. The incidence of perioperative symptomatic @entity4 and mortality were analyzed. RESULTS: A total of 2763 cases complicated with @entity3 underwent orthopedic surgery between January 2003 and October 2014. 823 nonpermanent filters were inserted. All filters were successfully deployed with no major complications. After a mean 14.2 days indwelling time, all of temporary filters were removed. Retrieval was attempted in 556 @entity0 with retrievable filters and was successful in 545 (98%); mean indwelling time was 16.3 days. The total retrieval rate was 90%. The incidence of @entity4 in the filter group was significantly lower compared with the two control groups. Among the @entity0 who received chemical anticoagulant therapy, the incidence of @entity4 in filter group, control group 1 and control group 2 were 0.14%, 1.60% and 2.10%, respectively. The incidence of @entity4 in filter group was also significant lower compared with control groups. CONCLUSION: Nonpermanent IVC filter placement seems like to be a safe and effective method for preventing perioperative symptomatic and fatal @entity4 in @entity1 @entity0 with @entity3 in the present retrospective study.

title: Evaluation of nonpermanent inferior vena cava filter placement in XXXX with @entity3 after @entity1 : A single-center retrospective study.

answer: @entity0


abstract: The genetic etiology of @entity0 has not been fully elucidated. Although germline mutations of high-penetrance genes such as @entity8 are implicated in development of @entity0 , at least half of all @entity0 families are not linked to these genes. To identify a comprehensive spectrum of genetic factors for @entity0 in a Chinese population, we performed an analysis of germline mutations in 2,165 coding exons of 152 genes associated with @entity5 using next-generation sequencing (NGS) in 99 @entity0 @entity1 from families of @entity2 @entity1 regardless of @entity2 types. Forty-two deleterious germline mutations were identified in 21 genes of 34 @entity1 , including 18 (18.2%) @entity6 or @entity4 mutations, 3 (3%) @entity3 mutations, 5 (5.1%) DNA mismatch repair gene mutations, 1 (1%) @entity7 mutation, 6 (6.1%) @entity9 pathway gene mutations, and 9 (9.1%) mutations in other genes. Of seven @entity1 who carried mutations in more than one gene, 4 were @entity6 /2 mutation carriers, and their average onset age was much younger than @entity1 with only @entity8 mutations. Almost all identified high-penetrance gene mutations in those families fulfill the typical phenotypes of @entity5 listed in the National @entity2 Network (NCCN) guidelines, except two @entity3 and three mismatch repair gene mutations. Furthermore, functional studies of @entity10 germline mutations confirmed the association between @entity10 mutation and tumorigenesis, and segregation analysis suggested antagonism between @entity6 and @entity10 . We also identified a lot of low-penetrance gene mutations. Although the clinical significance of those newly identified low-penetrance gene mutations has not been fully appreciated yet, these new findings do provide valuable epidemiological information for the future studies. Together, these findings highlight the importance of genetic testing based on NCCN guidelines and a multi-gene analysis using NGS may be a supplement to traditional genetic counseling.

title: Identification of a comprehensive spectrum of genetic factors for XXXX in a chinese population by next-generation sequencing.

answer: @entity0


abstract: INTRODUCTION: A major problem in cartilage repair is the lack of chondrogenic cells migrating from healthy tissue into defects. Cartilage is essentially avascular and therefore its healing is not considered to involve mononuclear cells. Peripheral blood derived mononuclear cells (PBMC) offer a readily available autologous cell source for clinical use and therefore this study was designed to evaluate the effects of PBMCs on chondrocytes and cartilage. METHODS: @entity0 primary chondrocytes and cartilage tissue explants were taken from @entity0 undergoing total knee replacement (n   =   17). Peripheral blood samples were obtained from healthy volunteers (n   =   12) and mononuclear cells were isolated by density-gradient centrifugation. Cell migration and chemokinetic potential were measured using a scratch assay, xCELLigence and CyQuant assay. PCR array and quantitative PCR was used to evaluate mRNA expression of 87 cell motility and/or chondrogenic genes. RESULTS: The chondrocyte migration rate was 2.6 times higher at 3 hour time point (p   <   0.0001) and total number of migrating chondrocytes was 9.7 times higher (p   <   0.0001) after three day indirect PBMC stimulus and 8.2 times higher (p   <   0.0001) after three day direct co-culture with PBMCs. A cartilage explant model confirmed that PBMCs also exert a chemokinetic role on ex vivo tissue. PBMC stimulation was found to significantly upregulate the mRNA levels of 2 chondrogenic genes; collagen type II ( @entity2 600-fold, p   <   0.0001) and @entity4 ( @entity4 30-fold, p   <   0.0001) and the mRNA levels of 7 genes central in cell motility and migration were differentially regulated by 24h PBMC stimulation. CONCLUSION: The results support the concept that PBMC treatment enhances chondrocyte migration without suppressing the chondrogenic phenotype possibly via mechanistic pathways involving @entity3 and @entity1 . In the future, peripheral blood mononuclear cells could be used as an autologous point-ofcare treatment to attract native chondrocytes from the diseased tissue to aid in cartilage repair.

title: Peripheral blood derived mononuclear cells enhance osteoarthritic XXXX chondrocyte migration.

answer: @entity0


abstract: INTRODUCTION: To evaluate the prognostic value of gross @entity2 volume (TV) in @entity0 with locally recurrent, nonmetastatic @entity4 . METHODS: Between 2001 and 2012, 291 consecutive @entity0 with locally recurrent, nonmetastatic @entity4 underwent salvage IMRT were retrospectively reviewed. The correlations between TV and recurrent T classification were analyzed. Survival analyses were performed. Receiver operating characteristic (ROC) curves were calculated to identify cut-off point of TV. The Akaike information criterion and Harrell's concordance index (c-index) were utilized to test the prognostic value. RESULTS: The median TV significantly increased with advancing recurrent T classification (P<0.001). The 5-year overall survival rate was 33.2% for the entire cohort. On multivariate analysis, TV was an independent negative prognostic factor for distant @entity1 -free survival (hazard ratio =1.013, P =0.003), overall survival (hazard ratio = 1.015, P<0.001) and @entity3 -related @entity5 (hazard ratio = 1.014, P<0.001). The 5-year overall survival rates were 63.1% and 20.8% for @entity0 with a TV < 22 cm3 and TV >= 22 cm3, respectively (P < 0.001). In @entity0 with TV <22 cm3, locoregional failure is the leading cause of @entity5 . In @entity0 with TV>= 22 cm3, distant @entity1 rate is higher and occurred within short term after local recurrence; meanwhile, radiation-induced injuries became more common and led to half of deaths in this group. The Akaike information criterion and c-index analyses indicated that the predictive ability of recurrent T classification improved when combined with TV. CONCLUSIONS: Our data suggests TV is a significant prognostic factor for predicting the distant @entity1 , overall survival and @entity3 -related @entity5 of @entity0 with locally recurrent, nonmetastatic @entity4 after salvage IMRT. TV should be considered when designing personalized salvage treatments for these @entity0 . For @entity0 with bulky local recurrent @entity2 , radiation may need to be de-emphasized in favor of systemic treatment or best supportive care.

title: Prognostic significance of @entity2 volume in locally recurrent XXXX treated with salvage intensity-modulated radiotherapy.

answer: @entity4


abstract: INTRODUCTION: To evaluate the prognostic value of gross @entity2 volume (TV) in @entity0 with locally recurrent, nonmetastatic @entity4 . METHODS: Between 2001 and 2012, 291 consecutive @entity0 with locally recurrent, nonmetastatic @entity4 underwent salvage IMRT were retrospectively reviewed. The correlations between TV and recurrent T classification were analyzed. Survival analyses were performed. Receiver operating characteristic (ROC) curves were calculated to identify cut-off point of TV. The Akaike information criterion and Harrell's concordance index (c-index) were utilized to test the prognostic value. RESULTS: The median TV significantly increased with advancing recurrent T classification (P<0.001). The 5-year overall survival rate was 33.2% for the entire cohort. On multivariate analysis, TV was an independent negative prognostic factor for distant @entity1 -free survival (hazard ratio =1.013, P =0.003), overall survival (hazard ratio = 1.015, P<0.001) and @entity3 -related @entity5 (hazard ratio = 1.014, P<0.001). The 5-year overall survival rates were 63.1% and 20.8% for @entity0 with a TV < 22 cm3 and TV >= 22 cm3, respectively (P < 0.001). In @entity0 with TV <22 cm3, locoregional failure is the leading cause of @entity5 . In @entity0 with TV>= 22 cm3, distant @entity1 rate is higher and occurred within short term after local recurrence; meanwhile, radiation-induced injuries became more common and led to half of deaths in this group. The Akaike information criterion and c-index analyses indicated that the predictive ability of recurrent T classification improved when combined with TV. CONCLUSIONS: Our data suggests TV is a significant prognostic factor for predicting the distant @entity1 , overall survival and @entity3 -related @entity5 of @entity0 with locally recurrent, nonmetastatic @entity4 after salvage IMRT. TV should be considered when designing personalized salvage treatments for these @entity0 . For @entity0 with bulky local recurrent @entity2 , radiation may need to be de-emphasized in favor of systemic treatment or best supportive care.

title: Prognostic significance of XXXX volume in locally recurrent @entity4 treated with salvage intensity-modulated radiotherapy.

answer: @entity2


abstract: BACKGROUND: Caudate lobe liver metastases occur commonly in @entity0 with @entity1 . It is unknown, however, how these lesions respond to regional therapy and how their presence impacts outcomes. We reviewed our experience treating these lesions using transarterial chemoembolization (TACE). METHODS: We reviewed radiographic response to TACE in 86 @entity0 with metastatic @entity1 to the liver. We determined the impact of caudate lesions on outcomes in comparison to the cohort of @entity0 without caudate lesions, as well as response of caudate lesions to TACE versus lesions elsewhere in the liver. RESULTS: Caudate lesions were identified in 45 (52%) @entity0 . All @entity0 had disease in other liver segments. Only seven caudate lesions (12.3%) had a radiographic response to TACE, whereas 82% of lesions elsewhere in the liver demonstrated a response. The presence or absence of a caudate lesion did not impact the overall radiographic (82.2% vs. 82.9%), symptomatic (64.4% vs. 56.1%), or biochemical (97.6% vs. 88.9%) response to TACE (P   >   0.1 for all). However, median overall survival was reduced in those presenting with caudate lesions (87.1 vs. 45.6  months, P   =   0.031). CONCLUSIONS: Metastatic @entity1 to the caudate lobe respond poorly to TACE. Symptomatic or threatening caudate lobe lesions should be considered for palliative resection in spite of additional inoperable liver metastases.

title: Transarterial chemoembolization is ineffective for XXXX metastatic to the caudate lobe: a single institution review.

answer: @entity1


abstract: OBJECTIVE: To determine the long-term results of @entity0 undergoing transcatheter coil embolization for the treatment of acute @entity1 . METHODS: @entity0 undergoing angiography for suspected @entity2 between January 2002 and December 2012 were reviewed (average age, 60   years; 38.4% male). Baseline, procedural and outcome parameters were recorded following the Society of Interventional Radiology guidelines. Primary outcome measures included early (<30   days) and delayed (>30   days) rebleeding events and adverse procedure-related complication. Average follow-up time was 996   days (median, 232   days; range, 30-3663   days). RESULTS: One or multiple sites of @entity1 were identified in 40 cases. Coil embolization was performed in 39 @entity0 , 26 (66.7%, 26/39) of whom were treated successfully without technical/clinical failure (n   =   12) or loss to follow-up (n   =   1). Three @entity0 (11.5%, 3/26) rebled in the early period within 30 days; one @entity0 went on to hemicolectomy. Four @entity0 (15.3%, 4/26) experienced delayed rebleeding after 30   days; two of whom also underwent hemicolectomy. No major complication occurred. One minor complication of @entity3 was seen in the clinical failure group. One case of asymptomatic ischaemia was identified on a @entity0 undergoing pre-operative colonoscopy for elective bowel resection. No instances of ischaemic stricture were seen. All-cause mortality of successfully treated and all @entity0 at 1   year was 31% (8/26) and 30% (12/40), respectively. CONCLUSION: Transcatheter coil embolization is a durable treatment option with a technical and clinical success rate of 67% in the setting of acute @entity1 . A modest level of rebleeding was seen among successfully treated @entity0 in both the early and delayed periods; in the majority of @entity0 , embolization proved to be definitive therapy. ADVANCES IN KNOWLEDGE: Transcatheter coil embolization is a durable and potentially definitive therapy in the management of acute @entity1 .

title: Long-term results of microcoil embolization for XXXX : how common is rebleeding?

answer: @entity1


abstract: @entity1 is on the declining trend in India according to the population-based registries; yet it continues to be a major public health problem for @entity0 in India. Multifactorial causation, potential for prevention, and the sheer threat it poses make @entity1 an important disease for in-depth studies, as has been attempted by this paper. This paper attempts to review the available knowledge regarding the epidemiology and pattern of @entity1 ; types of HPV ( @entity3 ) prevalent among @entity1 @entity0 and among @entity0 in general, high-risk groups such as commercial sex workers, and @entity2 ( @entity0 immunodeficiency virus)-positive @entity0 ; and the role of the national program on @entity1 in control efforts. The peak age of incidence of @entity1 is 55-59 years, and a considerable proportion of @entity0 report in the late stages of disease. Specific types of oncogenic @entity4 , 18 have been identified in @entity0 with @entity1 . Other epidemiological risk factors are early age at marriage, multiple sexual partners, @entity5 , poor genital hygiene, @entity6 , use of @entity7 , and lack of awareness. A multipronged approach is necessary which can target areas of high prevalence identified by registries with a combination of behavior change communication exercises and routine early screening with VIA. Sensitizing the @entity0 of the area, including menfolk, is necessary to increase uptake levels. Vaccination against types 16 and 18 can also be undertaken after taking into confidence all stakeholders, including the parents of adolescent @entity0 . Preventing and treating @entity1 and reducing the burden are possible by targeting resources to the areas with high prevalence.

title: Epidemiology of XXXX with special focus on India.

answer: @entity1


abstract: @entity1 is an important cause of end @entity2 . Rarely, these @entity0 may present with @entity4 caused by @entity1 . The aim of this study was to report a rare case of a @entity0 who arrived at the emergency department with @entity1 presenting with acute @entity3 and @entity4 . A 58-year-old male with @entity2 was admitted to the emergency department with acute @entity3 and @entity4 . The @entity0 was admitted to the Department of Surgery with diagnosis of acute abdomen and perirenal @entity5 . Although the @entity0 was on conservative treatment, his symptoms did not improve and the @entity0 was operated emergently. During exploration, there was bleeding from the right @entity6 , which was 30*20 cm in dimension. The @entity0 underwent nephrectomy and drainage of the @entity5 , and was discharged on the fifth postoperative day without any problems. Bleeding due to rupture of a cyst in @entity1 occurs rarely but it may be life threatening. Although conservative methods are often preferable in treatment, surgery can be life saving for @entity0 in whom the clinical situation does not improve.

title: Acute abdomen and @entity4 caused by spontaneous rupture of @entity1 in XXXX .

answer: @entity1


abstract: @entity1 is an important cause of end @entity2 . Rarely, these @entity0 may present with @entity4 caused by @entity1 . The aim of this study was to report a rare case of a @entity0 who arrived at the emergency department with @entity1 presenting with acute @entity3 and @entity4 . A 58-year-old male with @entity2 was admitted to the emergency department with acute @entity3 and @entity4 . The @entity0 was admitted to the Department of Surgery with diagnosis of acute abdomen and perirenal @entity5 . Although the @entity0 was on conservative treatment, his symptoms did not improve and the @entity0 was operated emergently. During exploration, there was bleeding from the right @entity6 , which was 30*20 cm in dimension. The @entity0 underwent nephrectomy and drainage of the @entity5 , and was discharged on the fifth postoperative day without any problems. Bleeding due to rupture of a cyst in @entity1 occurs rarely but it may be life threatening. Although conservative methods are often preferable in treatment, surgery can be life saving for @entity0 in whom the clinical situation does not improve.

title: Acute abdomen and @entity4 caused by spontaneous rupture of XXXX in @entity1 .

answer: @entity1


abstract: @entity1 is an important cause of end @entity2 . Rarely, these @entity0 may present with @entity4 caused by @entity1 . The aim of this study was to report a rare case of a @entity0 who arrived at the emergency department with @entity1 presenting with acute @entity3 and @entity4 . A 58-year-old male with @entity2 was admitted to the emergency department with acute @entity3 and @entity4 . The @entity0 was admitted to the Department of Surgery with diagnosis of acute abdomen and perirenal @entity5 . Although the @entity0 was on conservative treatment, his symptoms did not improve and the @entity0 was operated emergently. During exploration, there was bleeding from the right @entity6 , which was 30*20 cm in dimension. The @entity0 underwent nephrectomy and drainage of the @entity5 , and was discharged on the fifth postoperative day without any problems. Bleeding due to rupture of a cyst in @entity1 occurs rarely but it may be life threatening. Although conservative methods are often preferable in treatment, surgery can be life saving for @entity0 in whom the clinical situation does not improve.

title: Acute abdomen and XXXX caused by spontaneous rupture of @entity1 in @entity1 .

answer: @entity4


abstract: OBJECTIVE: Non-operative management of @entity4 has recently become more common. Especially non-operative treatment of blunt @entity3 is gaining wide acceptance. In this study, the efficacy of non-operative treatment in @entity3 (blunt penetrating) is discussed. MATERIAL AND METHODS: All @entity0 who received treatment due to @entity3 from November 2008 to January 2013 were retrospectively analyzed. The demographic characteristics, @entity1 , injured organ, type of treatment (operative vs. nonoperative) and mortality data were evaluated. RESULTS: The study includes 115 @entity0 treated for @entity3 in our department. The mechanism of @entity1 was stab wounds in 60%, blunt @entity3 in 23.5% and gunshot wounds in 16.5%. Forty-two @entity0 (36.5%) were operated for hemodynamic instability and/or @entity2 on admission. The remaining 63.5% of @entity0 (n=73) were treated nonoperatively, 10 of whom required laparotomy during follow-up. The remaining 63 @entity0 were treated with non-operative management. The success rate for non-operative treatment was 86.3% and there was no difference in terms of the types of @entity1 . The mortality rate was 4.3% (n= 5) in the whole series, but there were no deaths among the @entity0 who had received non-operative treatment. In the whole @entity0 group 54.2% (n=63) were treated nonoperatively. CONCLUSION: Nonoperative treatment in @entity3 is safe and effective. @entity0 with clinical stability and normal physical examination findings can be treated nonoperatively with close monitoring.

title: Conservative management of XXXX .

answer: @entity4