abstract: OBJECTIVE: To compare the perioperative data, pathological results and functional outcomes of transvesical single- site laparoscopic radical prostatectomy (TVSSLRP) with those of nerve-sparing extraperitoneal laparoscopic radical prostatectomy (nsELRP) in the treatment of @entity2 (PCa). METHODS: Fifty @entity0 with low-risk organ-confined PCa were randomly assigned to two groups of equal number to receive TVSSLRP and nsELRP, respectively. Comparisons were made between the two groups of @entity0 in such demographic and baseline data as age, comorbidity, body mass index (BMI), serum @entity3 , prostate volume, bioptic Gleason score, clinical stage, IIEF-5 score, nocturnal penile tumescence (NPT), penile brachial index (PBI), and penile arterial blood flow velocity as well as in such surgery-related parameters as operation duration, @entity1 , blood transfusion, @entity4 , positive surgical margin, catheterization time, hospital stay, and postoperative Gleason score, pathologic stage, urinal pad use, @entity3 level, IIEF-5 score, NPT, PBI and PABFV. RESULTS: All the operations were successfully performed. There were no statistically significant differences between the two groups either in the demographic and baseline data or in intraoperative @entity1 , blood transfusion rate, complications, and positive surgical margin. No @entity4 and positive surgical margins were found in either group. Compared with nsELRP, TVSSLRP achieved a significantly shorter operation duration ([151.46    40.68] min vs [105.92    26.21] min, P <0.05), catheterization time ([13.01    1.64] d vs [11.24    1.17] d, P <0.05), and hospital stay ([15.76    4.65] d vs [12.92    4.29] d, P <0.05). On the first day and at 1, 3 and 6 months after catheter removal, the urinary continence rates in the TVSSLRP and nsELRP groups were 84% vs 52% (P <0.05), 100% vs 84%, 100% vs 96%, and 100% vs 96%, respectively; and at 3, 6 and 12 months after surgery, the erectile potency rates were 48% vs 28% (P <0.05), 64% vs 52%, and 76% vs 68%, respectively, with an IIEF-5 score >=  18, all evidently higher in the TVSSLRP than in the nsELRP group. The penile brachial index and arterial blood flow velocity of the two groups of @entity0 exhibited no significant differences before and after surgery, nor did postoperative complications (grade II) between the TVSSLRP and nsELRP groups (32% vs 40%, P >0.05). The Gleason score and pathologic stage were increased after surgery, but with remarkable differences between the two groups (P >0.05). No biochemical recurrence was found in either group during a 12-month follow-up. CONCLUSION: With the advantages of safety and rapid postoperative recovery, both TVSSLRP and nsELRP are feasible for the treatment of low-risk organ-confined PCa, but the former may achieve an earlier recovery of urinary continence and erectile function than the latter.

title: [Functional outcomes of transvesical single-site versus extraperitoneal laparoscopic radical prostatectomy for XXXX ].

answer: @entity2


abstract: INTRODUCTION: Kinesio-Taping(  ) ( @entity4 -Tape) is used in sports traumatology with the aim of reducing @entity1 and improving blood and lymph circulation. The main objective of the present study was to assess the efficacy of K-Tape on early @entity2 after anterior cruciate ligament (ACL) reconstruction. The study hypothesis was that K-Tape significantly decreases @entity1 . METHOD: A prospective non-randomized comparative study was conducted in 2013-2014 and included all @entity0 who underwent primary ACL reconstruction by hamstring graft. @entity3 was standardized. Two groups, "K-Tape" and "controls", were formed according to the days on which the study physiotherapist was present. The K-Tape compression/decompression assembly was applied immediately postoperatively and maintained for 3days. @entity0 filled out online questionnaires. The main assessment criterion was mean @entity2 (D0-D3) on a 0-to-10 scale. Secondary criteria were @entity3 intake on the three WHO levels, awakening during the night of D0 due to @entity1 , signs of postoperative discomfort, and @entity0 satisfaction. RESULTS: Sixty @entity0 (30 per group) were included, 57 of whom could be assessed: 28 K-Tape, 29 controls; 44 male, 13 female; mean age, 30.9  8.9 years. At inclusion, the two groups were comparable. There was no significant difference in mean (D0-D3) knee @entity1 intensity: 3.8  2.2 for K-Tape, and 3.9  2 for controls (P=0.93). Analysis of variance (ANOVA) found no significant intergroup difference in evolution of @entity1 (P=0.34). There were no other significant differences on the other assessment criteria. CONCLUSION: K-Tape showed no efficacy on early @entity2 following ACL reconstruction. LEVEL OF EVIDENCE: III; prospective non-randomized comparative study.

title: Inefficacy of Kinesio-Taping(  ) on early XXXX after ACL reconstruction: Prospective comparative study.

answer: @entity2


abstract: UNASSIGNED: The flagellate @entity4 , which causes the @entity1 when infecting a @entity0 host, goes through an intricate life cycle. It has a rather complex propulsion mechanism and swims in diverse microenvironments. These continuously exert selective pressure, to which the trypanosome adjusts with its architecture and behavior. As a result, the trypanosome assumes a diversity of complex morphotypes during its life cycle. However, although cell biology has detailed form and function of most of them, experimental data on the dynamic behavior and development of most morphotypes is lacking. Here we show that simulation science can predict intermediate cell designs by conducting specific and controlled modifications of an accurate, nature-inspired cell model, which we developed using information from live cell analyses. The cell models account for several important characteristics of the real trypanosomal morphotypes, such as the geometry and elastic properties of the cell body, and their swimming mechanism using an eukaryotic flagellum. We introduce an elastic network model for the cell body, including bending @entity3 and simulate swimming in a fluid environment, using the mesoscale simulation technique called multi-particle collision dynamics. The in silico trypanosome of the bloodstream form displays the characteristic in vivo rotational and translational motility pattern that is crucial for survival and virulence in the vertebrate host. Moreover, our model accurately simulates the trypanosome's tumbling and backward motion. We show that the distinctive course of the attached flagellum around the cell body is one important aspect to produce the observed swimming behavior in a viscous fluid, and also required to reach the maximal swimming velocity. Changing details of the flagellar attachment generates less efficient swimmers. We also simulate different morphotypes that occur during the parasite's development in the tsetse @entity2 , and predict a flagellar course we have not been able to measure in experiments so far.

title: Simulating the Complex Cell Design of XXXX and Its Motility.

answer: @entity4


abstract: OBJECTIVES: To examine the risk of any @entity2 in @entity0 with both @entity5 ( @entity5 ) and @entity4 ( @entity4 ) vs @entity0 with @entity5 only. STUDY DESIGN: We performed a population-based cohort study. We defined @entity5 as individuals aged  <=30  years who had a diagnosis of @entity1 recorded in the Swedish National @entity0 Register between 1964 and 2009. Individuals with @entity4 were identified through biopsy report data between 1969 and 2008 from any of Sweden's 28 pathology departments. Some 958 individuals had both @entity5 and @entity4 and were matched for sex, age, and calendar period with 4598 reference individuals with @entity5 only. We then used a stratified Cox regression analysis, where @entity4 was modeled as a time-dependent covariate, to estimate the risk of any @entity2 and @entity6 ( @entity3 , distal forearm, thoracic and lumbar spine, and proximal humerus) in @entity0 with both @entity5 and @entity4 compared with that in @entity0 with @entity5 only. RESULTS: During follow-up, 12 @entity0 with @entity5 and @entity4 had a @entity2 (1 @entity6 ). @entity4 did not influence the risk of any @entity2 (adjusted hazard ratio  =  0.77; 95% CI  =  0.42-1.41) or @entity6 (adjusted hazard ratio  =  0.46; 95% CI  =  0.06-3.51) in @entity0 with @entity5 . Stratification for time since @entity4 diagnosis did not affect risk estimates. CONCLUSION: Having a diagnosis of @entity4 does not seem to influence @entity2 risk in young @entity0 with @entity5 . Follow-up in this study was, however, too short to ascertain @entity6 which traditionally occur in old age.

title: XXXX Does Not Influence Fracture Risk in Young @entity0 with  Type 1 @entity1 .

answer: @entity4


abstract: OBJECTIVES: To examine the risk of any @entity2 in @entity0 with both @entity5 ( @entity5 ) and @entity4 ( @entity4 ) vs @entity0 with @entity5 only. STUDY DESIGN: We performed a population-based cohort study. We defined @entity5 as individuals aged  <=30  years who had a diagnosis of @entity1 recorded in the Swedish National @entity0 Register between 1964 and 2009. Individuals with @entity4 were identified through biopsy report data between 1969 and 2008 from any of Sweden's 28 pathology departments. Some 958 individuals had both @entity5 and @entity4 and were matched for sex, age, and calendar period with 4598 reference individuals with @entity5 only. We then used a stratified Cox regression analysis, where @entity4 was modeled as a time-dependent covariate, to estimate the risk of any @entity2 and @entity6 ( @entity3 , distal forearm, thoracic and lumbar spine, and proximal humerus) in @entity0 with both @entity5 and @entity4 compared with that in @entity0 with @entity5 only. RESULTS: During follow-up, 12 @entity0 with @entity5 and @entity4 had a @entity2 (1 @entity6 ). @entity4 did not influence the risk of any @entity2 (adjusted hazard ratio  =  0.77; 95% CI  =  0.42-1.41) or @entity6 (adjusted hazard ratio  =  0.46; 95% CI  =  0.06-3.51) in @entity0 with @entity5 . Stratification for time since @entity4 diagnosis did not affect risk estimates. CONCLUSION: Having a diagnosis of @entity4 does not seem to influence @entity2 risk in young @entity0 with @entity5 . Follow-up in this study was, however, too short to ascertain @entity6 which traditionally occur in old age.

title: @entity4 Does Not Influence Fracture Risk in Young @entity0 with  Type 1 XXXX .

answer: @entity1


abstract: OBJECTIVES: To examine the risk of any @entity2 in @entity0 with both @entity5 ( @entity5 ) and @entity4 ( @entity4 ) vs @entity0 with @entity5 only. STUDY DESIGN: We performed a population-based cohort study. We defined @entity5 as individuals aged  <=30  years who had a diagnosis of @entity1 recorded in the Swedish National @entity0 Register between 1964 and 2009. Individuals with @entity4 were identified through biopsy report data between 1969 and 2008 from any of Sweden's 28 pathology departments. Some 958 individuals had both @entity5 and @entity4 and were matched for sex, age, and calendar period with 4598 reference individuals with @entity5 only. We then used a stratified Cox regression analysis, where @entity4 was modeled as a time-dependent covariate, to estimate the risk of any @entity2 and @entity6 ( @entity3 , distal forearm, thoracic and lumbar spine, and proximal humerus) in @entity0 with both @entity5 and @entity4 compared with that in @entity0 with @entity5 only. RESULTS: During follow-up, 12 @entity0 with @entity5 and @entity4 had a @entity2 (1 @entity6 ). @entity4 did not influence the risk of any @entity2 (adjusted hazard ratio  =  0.77; 95% CI  =  0.42-1.41) or @entity6 (adjusted hazard ratio  =  0.46; 95% CI  =  0.06-3.51) in @entity0 with @entity5 . Stratification for time since @entity4 diagnosis did not affect risk estimates. CONCLUSION: Having a diagnosis of @entity4 does not seem to influence @entity2 risk in young @entity0 with @entity5 . Follow-up in this study was, however, too short to ascertain @entity6 which traditionally occur in old age.

title: @entity4 Does Not Influence Fracture Risk in Young XXXX with  Type 1 @entity1 .

answer: @entity0


abstract: BACKGROUND: @entity5 is characterized by transient @entity2 that  mimics a @entity4 in the absence of obstructive @entity3 . The onset is frequently triggered by an acute illness or intense physical or emotional stress. CASE REPORT: We describe the case of a 47-year-old @entity0 who was brought to the emergency department with acute onset @entity6 while scuba diving. She was found to have @entity8 radiographically. Her troponins were noted to be positive. Initial echocardiogram showed @entity9 with @entity7 of apex. She was treated with noninvasive ventilation and intravenous diuretic therapy and her symptoms significantly improved. She subsequently underwent cardiac catheterization which revealed nonobstructive @entity3 . An exercise stress echocardiogram was performed 2  days later that revealed resolution of the wall motion abnormality and no @entity1 at high levels of exercise. A diagnosis of reverse stress (Takotsubo) @entity2 was made based on Mayo Clinic Diagnostic criteria.    WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: This case brings to light the risk of @entity5 in divers. The diagnosis should be considered in @entity0 presenting with @entity8 during diving.

title: XXXX Caused by Diving: Case Report and  Review  of  the Literature.

answer: @entity5


abstract: BACKGROUND: Inflammatory markers have been studied in @entity2 ( @entity2 ) for diagnosis, disease activity, and prediction of relapse. Blood neutrophil-to-lymphocyte (N/L) ratio has been used to determine outcomes of some @entity1 and @entity4 . Blood N/L ratio is a simple sign of clinical @entity3 . In this study, we examined N/L ratio in recurrent @entity0 suffering from @entity2 . METHODS: The aim of the present study was to analyze N/L ratios in serum samples of @entity2 @entity0 in remission and active phases. @entity0 ' age, extend of the disease, disease duration, disease activity, drug, and other medical history were all noted for @entity0 . @entity5 , erythrocyte sedimentation rate, and complete blood count were determined for @entity0 . RESULTS: Forty-nine @entity2 @entity0 were admitted into the present study. The blood N/L ratios were significantly increased in active phase compared with inactive @entity2 @entity0 (p  <  0.05). The cut-off value for N/L ratio for the detection of active @entity2 @entity0 was calculated as >=   2.3 using receiver operating characteristic analysis [sensitivity: 61.2  %, specificity: 66.7  %, AUC: 0.650 (0.540-0.760), p  =  0.01]. CONCLUSIONS: Present study shows that in @entity0 with @entity2 , the blood N/L ratio is associated with active disease. N/L ratio may be used as an activity parameter in @entity2 .

title: Does neutrophil-to-lymphocyte ratio predict active XXXX ?

answer: @entity2


abstract: BACKGROUND: Comprehensive and long-term @entity0 education programs designed to improve self-management can help @entity0 better manage their medical condition. Using disease management programs (DMPs) that were created for each of the risk factor according to clinical practice guidelines, we evaluate their influence on the prevention of @entity3 recurrence. METHODS: This is a randomized study conducted with @entity5 @entity0 within 1  year from their onset. Subjects in the intervention group received a 6-month DMPs that included self-management education provided by a nurse along with support in collaboration with the primary care physician. Those in the usual care group received ordinary outpatient care. The  primary end points are @entity3 recurrence and @entity3 death. @entity0 were enrolled for 2  years with plans for a 2-year follow-up after the 6-month education period (total of 30  months). RESULTS: A total of 321 eligible subjects (average age, 67.3  years; females, 96 [29.9%]), including 21 subjects (6.5%) with transient @entity2 attack, were enrolled in this study. Regarding risk factors for @entity3 , 260 subjects (81.0%) had @entity4 , 249 subjects (77.6%) had @entity8 , 102 subjects (31.8%) had @entity1 , 47 subjects (14.6%) had @entity7 , and 98 subjects (30.5%) had @entity6 . There were no significant differences between the 2 groups with respect to subject characteristics. CONCLUSIONS: This article describes the rationale, design, and baseline features of a randomized controlled trial that aimed to assess the effects of DMPs for the secondary prevention of @entity3 . Subject follow-up is in progress and will end in  2015.

title: Baseline Feature of a Randomized Trial Assessing the Effects of Disease Management Programs for the Prevention of Recurrent XXXX .

answer: @entity5


abstract: UNASSIGNED: This study aimed to evaluate the prevalence and the relationship of @entity3 ( @entity3 ) and laryngeal motility alterations in @entity0 with @entity2 after vagus nerve stimulator (VNS) implantation. Twenty-three consecutive @entity0 with medically @entity2 underwent out-of-center sleep testing before and after VNS implantation. Eighteen eligible subjects underwent endoscopic laryngeal examination post-VNS implantation. Statistical analysis was carried out to assess an association between laryngeal motility alterations and the onset/worsening of @entity3 . After VNS implantation, 11 @entity0 showed a new-onset mild/moderate SBD. Half of the @entity0 already affected by @entity1 ( @entity1 ) showed worsening of SBD. All of the @entity0 with a new-onset @entity1 had a laryngeal pattern with left vocal cord adduction (LVCA) during VNS stimulation. The association between VNS-induced LVCA and SBD was statistically significant. This study suggests an association between VNS and SBD, hinting to a pivotal role of laryngeal motility alterations. The relationship between SBD and VNS-induced LVCA supports the need to routinely investigate sleep respiratory and laryngeal motility patterns before and after VNS implantation.

title: Laryngeal motility alteration: A missing link between @entity3 and vagus nerve stimulation for XXXX .

answer: @entity2


abstract: UNASSIGNED: This study aimed to evaluate the prevalence and the relationship of @entity3 ( @entity3 ) and laryngeal motility alterations in @entity0 with @entity2 after vagus nerve stimulator (VNS) implantation. Twenty-three consecutive @entity0 with medically @entity2 underwent out-of-center sleep testing before and after VNS implantation. Eighteen eligible subjects underwent endoscopic laryngeal examination post-VNS implantation. Statistical analysis was carried out to assess an association between laryngeal motility alterations and the onset/worsening of @entity3 . After VNS implantation, 11 @entity0 showed a new-onset mild/moderate SBD. Half of the @entity0 already affected by @entity1 ( @entity1 ) showed worsening of SBD. All of the @entity0 with a new-onset @entity1 had a laryngeal pattern with left vocal cord adduction (LVCA) during VNS stimulation. The association between VNS-induced LVCA and SBD was statistically significant. This study suggests an association between VNS and SBD, hinting to a pivotal role of laryngeal motility alterations. The relationship between SBD and VNS-induced LVCA supports the need to routinely investigate sleep respiratory and laryngeal motility patterns before and after VNS implantation.

title: Laryngeal motility alteration: A missing link between XXXX and vagus nerve stimulation for @entity2 .

answer: @entity3


abstract: Between August 1973 and May 1979, 18 @entity0 suffering from severe @entity1 A underwent synovectomy for recurrent haemarthroses, resistant to medical management. A total of 23 joints (11 knees and 12 elbows) were subjected to operation, five @entity0 undergoing two synovectomies on different joints. Post-operative follow-up period ranged from 12 to 58 months for @entity5 and from 29 to 76 months for knee synovectomy. All @entity0 experienced fewer haemarthroses, the average number of @entity2 episodes per joint over a 12 month period being reduced from 19 to 3 for knee joints, and from 24 to 3 for @entity4 . This improvement was apparent in the immediate post-operative year and maintained thereafter. Over the same follow-up period nine of the 11 knee joints were found to have lost an average 42 degrees mobility. Following @entity5 five out of 12 @entity0 lost an average of 28 degrees mobility; six @entity0 gained an average 11 degrees mobility. The post-operative complication rate was high for knee synovectomy, 54% suffering @entity2 despite haemostatic factor @entity3 levels. For @entity5 the rate was much lower, 75% of operations being uncomplicated. The average in- @entity0 time for knee operation was 75 d, and for the elbow 19 d. We conclude that synovectomy of the knee joint is to be avoided when other means of reducing @entity2 episodes are available, whereas @entity5 retains a useful role in the treatment of recurrent haemarthroses which do not respond to clotting factor prophylaxis.

title: The role of synovectomy in the management of recurrent haemarthroses in XXXX .

answer: @entity1


abstract: UNASSIGNED: Pseudokinases are classified by the lack of one or several of the highly conserved motifs involved in @entity3 (nt) binding or catalytic activity of protein kinases (PKs). Pseudokinases represent    10% of the @entity0 kinome and they are found in all evolutionary classes of kinases. It has become evident that pseudokinases, which were initially considered somewhat peculiar dead kinases, are important components in several signalling cascades. Furthermore, several pseudokinases have been linked to @entity0 diseases, particularly @entity1 , which is raising interest for therapeutic approaches towards these proteins. The @entity2 -binding pocket is a well-established drug target and elucidation of the mechanism and properties of nt binding in pseudokinases is of significant interest and importance. Recent studies have demonstrated that members of the pseudokinase family are very diverse in structure as well as in their ability and mechanism to bind nts or perform @entity4 transfer reactions. This diversity also precludes prediction of pseudokinase function, or the importance of nt binding for said function, based on primary sequence alone. Currently available data indicate that    40% of pseudokinases are able to bind nts, whereas only few are able to catalyse occasional @entity4 transfer. Pseudokinases employ diverse mechanisms to bind nts, which usually occurs at low, but physiological, affinity. @entity2 binding serves often a structural role but in most cases the functional roles are not precisely known. In the present review, we discuss the various mechanisms that pseudokinases employ for nt binding and how this often low-affinity binding can be accurately analysed.

title: XXXX -binding mechanisms in pseudokinases.

answer: @entity3


abstract: INTRODUCTION: @entity5 ( @entity5 ) is an important mediator of @entity2 . In addition to cells involved in @entity2 , sensory nociceptive neurons express the @entity5 signal-transducer @entity7 ( @entity7 ). These neurons are not only involved in @entity3 generation but also produce @entity9 by release of neuropeptides such as @entity8 ( @entity8 ). Whether @entity5 activation of sensory neurons contributes to the induction of @entity2 is unknown. This study explored whether the action of @entity5 on sensory neurons plays a role in the generation of @entity9 and @entity4 induction. METHODS: In SNS- @entity7 (-/-) @entity1 lacking @entity7 selectively in sensory neurons and appropriate control littermates (SNS- @entity7 (flox/flox)), we induced @entity4 ( @entity4 ), and assessed @entity0 , histopathological @entity4 scores, @entity3 scores, expression of @entity8 in sensory neurons, serum concentrations of @entity8 and cytokines, and the cytokine release from single cell suspensions from lymph nodes and spleens. In wild-type @entity1 @entity8 release was determined during development of @entity4 and, in cultured sensory neurons, upon @entity5 stimulation. RESULTS: Compared to SNS- @entity7 (flox/flox) @entity1 SNS- @entity7 (-/-) @entity1 showed significantly weaker @entity0 , reduced serum concentrations of @entity8 , @entity5 , and @entity6 , no @entity2 -evoked upregulation of @entity8 in sensory neurons, but similar histopathological @entity4 scores during @entity4 . During the @entity0 phase of @entity4 , @entity8 was significantly increased in the serum, knee and spleen. In vitro, @entity5 augmented the release of @entity8 from cultured sensory neurons. Upon antigen-specific restimulation lymphocytes from SNS- @entity7 (-/-) @entity1 released more interleukin-17 and interferon-y than lymphocytes from SNS- @entity7 (flox/flox) @entity1 . In naive lymphocytes from SNS- @entity7 (flox/flox) and SNS- @entity7 (-/-) @entity1 @entity8 reduced the release of @entity6 (a cytokine which inhibits the release of interleukin-17 and interferon-y). CONCLUSIONS: @entity5 signaling in sensory neurons plays a role in the expression of @entity4 . Selective deletion of @entity7 signaling in sensory neurons reduces the @entity0 of the joint (most likely by reducing @entity9 ) but increases some proinflammatory systemic cellular responses such as the release of interleukin-17 and interferon-y from lymphocytes upon antigen-specific restimulation. Thus @entity5 signaling in sensory neurons is not only involved in @entity3 generation but also in the coordination of the inflammatory response.

title: @entity5 -dependent influence of nociceptive sensory neurons on XXXX .

answer: @entity4


abstract: INTRODUCTION: @entity5 ( @entity5 ) is an important mediator of @entity2 . In addition to cells involved in @entity2 , sensory nociceptive neurons express the @entity5 signal-transducer @entity7 ( @entity7 ). These neurons are not only involved in @entity3 generation but also produce @entity9 by release of neuropeptides such as @entity8 ( @entity8 ). Whether @entity5 activation of sensory neurons contributes to the induction of @entity2 is unknown. This study explored whether the action of @entity5 on sensory neurons plays a role in the generation of @entity9 and @entity4 induction. METHODS: In SNS- @entity7 (-/-) @entity1 lacking @entity7 selectively in sensory neurons and appropriate control littermates (SNS- @entity7 (flox/flox)), we induced @entity4 ( @entity4 ), and assessed @entity0 , histopathological @entity4 scores, @entity3 scores, expression of @entity8 in sensory neurons, serum concentrations of @entity8 and cytokines, and the cytokine release from single cell suspensions from lymph nodes and spleens. In wild-type @entity1 @entity8 release was determined during development of @entity4 and, in cultured sensory neurons, upon @entity5 stimulation. RESULTS: Compared to SNS- @entity7 (flox/flox) @entity1 SNS- @entity7 (-/-) @entity1 showed significantly weaker @entity0 , reduced serum concentrations of @entity8 , @entity5 , and @entity6 , no @entity2 -evoked upregulation of @entity8 in sensory neurons, but similar histopathological @entity4 scores during @entity4 . During the @entity0 phase of @entity4 , @entity8 was significantly increased in the serum, knee and spleen. In vitro, @entity5 augmented the release of @entity8 from cultured sensory neurons. Upon antigen-specific restimulation lymphocytes from SNS- @entity7 (-/-) @entity1 released more interleukin-17 and interferon-y than lymphocytes from SNS- @entity7 (flox/flox) @entity1 . In naive lymphocytes from SNS- @entity7 (flox/flox) and SNS- @entity7 (-/-) @entity1 @entity8 reduced the release of @entity6 (a cytokine which inhibits the release of interleukin-17 and interferon-y). CONCLUSIONS: @entity5 signaling in sensory neurons plays a role in the expression of @entity4 . Selective deletion of @entity7 signaling in sensory neurons reduces the @entity0 of the joint (most likely by reducing @entity9 ) but increases some proinflammatory systemic cellular responses such as the release of interleukin-17 and interferon-y from lymphocytes upon antigen-specific restimulation. Thus @entity5 signaling in sensory neurons is not only involved in @entity3 generation but also in the coordination of the inflammatory response.

title: XXXX -dependent influence of nociceptive sensory neurons on @entity4 .

answer: @entity5


abstract: UNASSIGNED: Essential oil extracted from Chamaecyparis obtusa (EOCO) consists of several @entity7 with anti-inflammatory effects. @entity7 are expected to have an analgesic effect through inhibition of pro-inflammatory mediators. The present study investigated the anti-nociceptive and anti-inflammatory effects of EOCO in animal models of @entity6 . Intraperitoneal injection with EOCO (5 or 10mg/kg), @entity5 (positive control, 300mg/kg), or @entity14 (negative control) was performed 1h before the nociception tests: @entity11 -induced writhing response, @entity8 test, and hot plate test in @entity1 , and acidic saline-induced @entity12 in @entity3 . The expression of pro-inflammatory cytokines and pro-inflammatory enzymes in @entity8 -injected paws was determined by ELISA and western blotting, respectively. Treatment with EOCO significantly reduced @entity11 -induced writhing and paw-licking time in late response of the @entity8 tests. The anti-nociceptive effect was comparable with @entity5 . However, EOCO did not affect the reaction time of licking of the hind paws or jumping in hot plate test and the mechanical withdrawal thresholds in acidic saline-induced @entity12 model. @entity8 -injected paws of @entity1 treated with EOCO revealed the down-regulated expression of @entity0 @entity4 factor-a, @entity9 , inducible @entity10 synthase, and @entity13 , as compared with those of control @entity1 . These data showed the anti-nociceptive and anti-inflammatory effects of EOCO. The @entity6 -relieving effect might be attributed to inhibition of peripheral @entity6 in association with inflammatory response. EOCO could be a useful therapeutic strategy to manage @entity6 and @entity2 .

title: Antinociceptive and anti-inflammatory effects of essential oil extracted from Chamaecyparis obtusa in XXXX .

answer: @entity1


abstract: PURPOSE: Results of a study of an opioid-sparing protocol for acute @entity1 management in the @entity2 ( @entity2 ) are reported. METHODS: The @entity2 of a large hospital conducted a project, the "Opioid-Free Shift," to test a multimodal pharmacologic approach to analgesic therapy as an alternative to routine use of opioids. During a specified eight-hour period, all adults arriving at the @entity2 with a complaint of @entity1 were treated according to an opioid-sparing protocol based on principles of channel enzyme receptor-targeted analgesia (CERTA). @entity1 severity was assessed at baseline and at 30 and 60 minutes after analgesia administration using a validated rating scale. RESULTS: Seventeen @entity0 were treated in the @entity2 for acute or @entity3 during the study period. The median @entity1 score on the 11-point rating scale was 8 (range, 4-10) at baseline, declining to 6 (range, 0-10) at 30 minutes and to 5 (range, 1-10) at 60 minutes. At 30 minutes, 7 @entity0 (41%) had a @entity1 score reduction of >= 30% and 3 (18%) had a reduction of >= 50%. Six of the 15 @entity0 (40%) reassessed at 60 minutes had a @entity1 score reduction of >= 30%; 4 @entity0 (27%) had a reduction of >= 50%. More than 80% of @entity0 were satisfied with the @entity1 relief provided through the CERTA-based protocol, and no adverse drug reactions were reported. CONCLUSION: The 17 @entity0 treated for acute or @entity3 during the opioid-free shift were managed mainly with i.v. @entity5 and oral @entity4 , with only 1 @entity0 requiring rescue opioid therapy.

title: Development of an opioid reduction protocol in an XXXX .

answer: @entity2


abstract: UNASSIGNED: Risk factors for adolescent overweight and @entity1 include low levels of physical activity, high levels of sedentary behavior, low fruit and vegetable intake, and low socioeconomic position (SEP). To date, the vast majority of research investigating associations between lifestyle behaviors and weight status analyze dietary and time use factors separately. Our research aimed to describe Australian youth time use and diet clusters and explore relationships with weight status and SEP (parental education and income). Cluster analysis of the National @entity0 's Nutrition and Physical Activity Survey data from Australians aged 9 to 16 years (random sample n = 1,853) was conducted. Time use data (17 age-adjusted time use variables) and dietary data (7 age-adjusted diet variables) were collected via 24-hour recalls. Two clusters were associated with a reduced frequency of overweight and @entity1 (the @entity0 ' Active Sitter and @entity0 ' Healthy @entity2 ) and one with an increased frequency of overweight and @entity1 (the @entity0 ' Unhealthy cluster). Of these three clusters, two demonstrated associations with parental income and/or parental education level. The @entity0 ' Unhealthy cluster was associated with low SEP status (parental income and education), and the @entity0 ' Healthy Academic cluster was associated with high parental income. Not all unhealthy adolescent clusters were associated with overweight and @entity1 . The findings suggest sex-specific diet and activity clusters can be used to identify at-risk subgroups and inform multifaceted interventions to address overweight and @entity1 .

title: Adolescent Diet and Time Use Clusters and Associations With XXXX and Socioeconomic Position.

answer: @entity1


abstract: BACKGROUND: Recent guidelines recommend the @entity3 prediction models MMRPredict, MMRPro, and PREMM1,2,6 for the identification of MMR gene mutation carriers. We compared the predictive performance and clinical usefulness of these prediction models to identify mutation carriers. METHODS: Pedigree data from @entity2 @entity0 in 11 North American, European, and Australian cohorts (6 clinic- and 5 population-based sites) were used to calculate predicted probabilities of pathogenic @entity7 , @entity4 , or @entity5 gene mutations by each model and gene-specific predictions by MMRPro and PREMM1,2,6. We examined discrimination with area under the receiver operating characteristic curve (AUC), calibration with observed to expected (O/E) ratio, and clinical usefulness using decision curve analysis to select @entity0 for further evaluation. All statistical tests were two-sided. RESULTS: Mutations were detected in 539 of 2304 (23%) individuals from the clinic-based cohorts (237 @entity7 , 251 @entity4 , 51 @entity5 ) and 150 of 3451 (4.4%) individuals from the population-based cohorts (47 @entity7 , 71 @entity4 , 32 @entity5 ). Discrimination was similar for clinic- and population-based cohorts: AUCs of 0.76 vs 0.77 for MMRPredict, 0.82 vs 0.85 for MMRPro, and 0.85 vs 0.88 for PREMM1,2,6. For clinic- and population-based cohorts, O/E deviated from 1 for MMRPredict (0.38 and 0.31, respectively) and MMRPro (0.62 and 0.36) but were more satisfactory for PREMM1,2,6 (1.0 and 0.70). MMRPro or PREMM1,2,6 predictions were clinically useful at thresholds of 5% or greater and in particular at greater than 15%. CONCLUSIONS: MMRPro and PREMM1,2,6 can well be used to select @entity2 @entity0 from genetics clinics or population-based settings for @entity1 and/or germline testing at a 5% or higher risk. If no @entity6 is detected and risk exceeds 15%, we suggest considering additional genetic etiologies for the cause of @entity1 in the family.

title: Comparison of Prediction Models for XXXX Among Individuals With @entity2 .

answer: @entity3


abstract: BACKGROUND: Recent guidelines recommend the @entity3 prediction models MMRPredict, MMRPro, and PREMM1,2,6 for the identification of MMR gene mutation carriers. We compared the predictive performance and clinical usefulness of these prediction models to identify mutation carriers. METHODS: Pedigree data from @entity2 @entity0 in 11 North American, European, and Australian cohorts (6 clinic- and 5 population-based sites) were used to calculate predicted probabilities of pathogenic @entity7 , @entity4 , or @entity5 gene mutations by each model and gene-specific predictions by MMRPro and PREMM1,2,6. We examined discrimination with area under the receiver operating characteristic curve (AUC), calibration with observed to expected (O/E) ratio, and clinical usefulness using decision curve analysis to select @entity0 for further evaluation. All statistical tests were two-sided. RESULTS: Mutations were detected in 539 of 2304 (23%) individuals from the clinic-based cohorts (237 @entity7 , 251 @entity4 , 51 @entity5 ) and 150 of 3451 (4.4%) individuals from the population-based cohorts (47 @entity7 , 71 @entity4 , 32 @entity5 ). Discrimination was similar for clinic- and population-based cohorts: AUCs of 0.76 vs 0.77 for MMRPredict, 0.82 vs 0.85 for MMRPro, and 0.85 vs 0.88 for PREMM1,2,6. For clinic- and population-based cohorts, O/E deviated from 1 for MMRPredict (0.38 and 0.31, respectively) and MMRPro (0.62 and 0.36) but were more satisfactory for PREMM1,2,6 (1.0 and 0.70). MMRPro or PREMM1,2,6 predictions were clinically useful at thresholds of 5% or greater and in particular at greater than 15%. CONCLUSIONS: MMRPro and PREMM1,2,6 can well be used to select @entity2 @entity0 from genetics clinics or population-based settings for @entity1 and/or germline testing at a 5% or higher risk. If no @entity6 is detected and risk exceeds 15%, we suggest considering additional genetic etiologies for the cause of @entity1 in the family.

title: Comparison of Prediction Models for @entity3 Among Individuals With XXXX .

answer: @entity2


abstract: AIM: To develop a statistical index based on the phase space reconstruction (PSR) of the electrocardiogram (ECG) for the accurate and timely diagnosis of @entity1 ( @entity1 ) and @entity2 ( @entity2 ). METHODS: Thirty-two ECGs with sinus rhythm (SR) and 32 ECGs with @entity1 / @entity2 were analyzed using the PSR technique. Firstly, the method of time delay embedding were employed with the insertion of delay "  " in the original time-series X(t), which produces the Y(t)=X(t-  ). Afterwards, a PSR diagram was reconstructed by plotting Y(t) against X(t). The method of box counting was applied to analyze the behavior of the PSR trajectories. Measures as mean ( ), standard deviation (  ) and coefficient of variation (CV=  / ), kurtosis (b) for the box counting of PSR diagrams were reported. RESULTS: During SR, CV was always <0.05, while with the onset of @entity0 CV increased >0.05. A similar pattern was observed with b, where <6 was considered as the cut-off point between SR and @entity1 / @entity2 . Therefore, the upper threshold for SR was considered CVth=0.05 and bth<6. For optimisation of the accuracy, a new index (J) was proposed: J=wCVCVth+1-wbbth. During SR the upper limit of J was the value of 1. Furthermore CV, b and J crossed the cut-off point timely before the onset of @entity0 (average time: 4min 31s; SD: 2min 30s); allowing sufficient time for preventive therapy. CONCLUSION: The J index improved ECG utility for @entity0 monitoring and detection utility, allowing the prompt and accurate diagnosis of @entity0 .

title: Prompt and accurate diagnosis of XXXX with a novel index based on phase space reconstruction of ECG.

answer: @entity0


abstract: @entity3 ( @entity3 ) is a @entity2 characterized by autoimmune-mediated destruction of pancreatic insulin-producing beta cells. Interleukin (IL)-18 is a pro-inflammatory cytokine implicated in the pathogenesis of a number of inflammatory diseases. Here, we analyzed @entity4 levels in the plasma of juveniles with @entity3 . Compared to control subjects, @entity4 levels were significantly elevated in @entity0 with @entity3 . On the other hand, levels of @entity5 ( @entity5 ) and @entity6 , two negative regulators of @entity4 function, remained unchanged when comparing @entity3 to control samples. Notably, however, although @entity5 levels were not elevated, @entity4 and @entity5 were found to be positively correlated in type 1 @entity1 . Even so, free, unbound @entity4 remained significantly increased in @entity1 @entity0 . Additionally, correlation studies also revealed that @entity4 and @entity5 are positively correlated with HbA1c levels in @entity3 @entity0 , suggesting a potential link between @entity4 and metabolic control in these @entity0 . Finally, we observed a significant increase in @entity4 protein expression within @entity0 pancreatic islet specimens collected from type 1 @entity1 . These results further expand our knowledge of the role of @entity4 in @entity3 , may give insight into common pathogenic mechanisms associated with metabolic control in both @entity3 and T2D, and suggest that targeting this cytokine may improve therapeutic outcomes for @entity3 @entity0 .

title: Increased expression of @entity4 in the serum and islets of type 1 XXXX .

answer: @entity1


abstract: @entity3 ( @entity3 ) is a @entity2 characterized by autoimmune-mediated destruction of pancreatic insulin-producing beta cells. Interleukin (IL)-18 is a pro-inflammatory cytokine implicated in the pathogenesis of a number of inflammatory diseases. Here, we analyzed @entity4 levels in the plasma of juveniles with @entity3 . Compared to control subjects, @entity4 levels were significantly elevated in @entity0 with @entity3 . On the other hand, levels of @entity5 ( @entity5 ) and @entity6 , two negative regulators of @entity4 function, remained unchanged when comparing @entity3 to control samples. Notably, however, although @entity5 levels were not elevated, @entity4 and @entity5 were found to be positively correlated in type 1 @entity1 . Even so, free, unbound @entity4 remained significantly increased in @entity1 @entity0 . Additionally, correlation studies also revealed that @entity4 and @entity5 are positively correlated with HbA1c levels in @entity3 @entity0 , suggesting a potential link between @entity4 and metabolic control in these @entity0 . Finally, we observed a significant increase in @entity4 protein expression within @entity0 pancreatic islet specimens collected from type 1 @entity1 . These results further expand our knowledge of the role of @entity4 in @entity3 , may give insight into common pathogenic mechanisms associated with metabolic control in both @entity3 and T2D, and suggest that targeting this cytokine may improve therapeutic outcomes for @entity3 @entity0 .

title: Increased expression of XXXX in the serum and islets of type 1 @entity1 .

answer: @entity4


abstract: UNASSIGNED: Upper @entity3 originating in the oesophagus and stomach often present late and have a very poor prognosis. Treatment options include surgery for localised disease but, increasingly, neoadjuvant chemotherapy and radiotherapy is being employed to improve outcome. There is often a variable response to neoadjuvant treatment between individual @entity0 and side effects are relatively common. There is an urgent need for novel biomarkers of upper @entity3 , not only to improve screening and early diagnosis of the oesophageal and @entity1 when treatment options are potentially more effective, but also to accurately guide therapy in more @entity2 . The development of predictive biomarkers will also help to more effectively identify those @entity0 that will benefit from targeted therapies. Although many promising results have been derived from these studies there remains a lack of validated clinically applicable biomarkers available for translation into routine clinical use. This review will provide an overview of the recent proteomic research on upper @entity3 protein biomarker identification and validation. The challenges faced in the development of validated, clinically acceptable and accurate protein biomarkers will also be discussed, along with possible areas of future progress. This article is protected by copyright. All rights reserved.

title: Progress in the development of protein biomarkers of oesophageal and XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity4 ( @entity7 ) and @entity5 ( @entity6 ) are common ingredients in household bathroom and kitchen cleaning sprays. @entity7 + @entity6 cause reproductive @entity2 in @entity1 . The aim of the present study was to investigate gender-specific reproductive effects from @entity7 + @entity6 . Female reproduction was assessed through ovulation, oocyte implantation, and estrus cycling. Male reproductive function was assessed by sperm concentration, motility, and viability. Numbers of corpora lutea were not different after 2 weeks, but decreased after 8 weeks of @entity7 + @entity6 exposure. Dams exposed for 5 weeks to @entity7 + @entity6 spent significantly less time in estrus. @entity7 + @entity6 exposed males exhibited declines in both sperm concentration and motility, but not sperm viability. @entity3 in @entity1 from @entity7 + @entity6 exposure is, therefore, mediated through reproductive disturbances in both females and males. While the effect of @entity7 + @entity6 exposure on @entity0 health is unclear, widespread exposure necessitates further consideration of their potential reproductive @entity2 .

title: Quaternary ammonium disinfectants cause XXXX in @entity1 by targeting both male and female reproductive processes.

answer: @entity3


abstract: UNASSIGNED: @entity4 ( @entity7 ) and @entity5 ( @entity6 ) are common ingredients in household bathroom and kitchen cleaning sprays. @entity7 + @entity6 cause reproductive @entity2 in @entity1 . The aim of the present study was to investigate gender-specific reproductive effects from @entity7 + @entity6 . Female reproduction was assessed through ovulation, oocyte implantation, and estrus cycling. Male reproductive function was assessed by sperm concentration, motility, and viability. Numbers of corpora lutea were not different after 2 weeks, but decreased after 8 weeks of @entity7 + @entity6 exposure. Dams exposed for 5 weeks to @entity7 + @entity6 spent significantly less time in estrus. @entity7 + @entity6 exposed males exhibited declines in both sperm concentration and motility, but not sperm viability. @entity3 in @entity1 from @entity7 + @entity6 exposure is, therefore, mediated through reproductive disturbances in both females and males. While the effect of @entity7 + @entity6 exposure on @entity0 health is unclear, widespread exposure necessitates further consideration of their potential reproductive @entity2 .

title: Quaternary ammonium disinfectants cause @entity3 in XXXX by targeting both male and female reproductive processes.

answer: @entity1


abstract: PURPOSE: @entity6 ( @entity6 ) is a common @entity3 of ambulatory pediatric surgery done under general anesthesia with @entity7 . However, perioperative analgesic techniques have been shown to reduce @entity7 -induced @entity6 . The primary objective of this investigation was to examine whether an ultrasound-guided ilioinguinal/iliohypogastric (II/IH) @entity5 for ambulatory pediatric @entity2 could reduce the incidence of @entity7 -induced @entity6 . METHODS: The subjects of this prospective randomized double-blind study were 40 @entity0 ranging in age from 1 to 6  years, who were scheduled to undergo ambulatory @entity2 . The @entity0 were randomized to either receive or not to receive an ultrasound-guided II/IH @entity5 (Group B and Group NB, respectively). General anesthesia was maintained with @entity7 and @entity8 . The primary outcome assessed was @entity6 , evaluated using the Pediatric Anesthesia Emergence @entity6 (PAED) scale 30  min after emergence from general anesthesia. The secondary outcomes assessed were @entity4 , evaluated using the @entity1 ( @entity1 ), and the amount of intra-operative @entity7 given. RESULTS: The median PAED scale scores did not differ between Groups B and NB at 30  min (P  =  0.41). @entity1 scores also did not differ significantly between the groups, but the mean amount of intraoperative @entity7 given was significantly lower in Group B than in Group NB (P  <  0.01). CONCLUSIONS: Ultrasound-guided II/IH @entity5 for ambulatory pediatric @entity2 did not reduce @entity6 , but it did decrease the amount of intra-operative @entity7 needed. CLINICAL TRIAL REGISTRATION: UMIN000008586.

title: Ultrasound-guided ilioinguinal/iliohypogastric block did not reduce emergence @entity6 after ambulatory pediatric XXXX : a prospective randomized double-blind study.

answer: @entity2


abstract: PURPOSE: @entity6 ( @entity6 ) is a common @entity3 of ambulatory pediatric surgery done under general anesthesia with @entity7 . However, perioperative analgesic techniques have been shown to reduce @entity7 -induced @entity6 . The primary objective of this investigation was to examine whether an ultrasound-guided ilioinguinal/iliohypogastric (II/IH) @entity5 for ambulatory pediatric @entity2 could reduce the incidence of @entity7 -induced @entity6 . METHODS: The subjects of this prospective randomized double-blind study were 40 @entity0 ranging in age from 1 to 6  years, who were scheduled to undergo ambulatory @entity2 . The @entity0 were randomized to either receive or not to receive an ultrasound-guided II/IH @entity5 (Group B and Group NB, respectively). General anesthesia was maintained with @entity7 and @entity8 . The primary outcome assessed was @entity6 , evaluated using the Pediatric Anesthesia Emergence @entity6 (PAED) scale 30  min after emergence from general anesthesia. The secondary outcomes assessed were @entity4 , evaluated using the @entity1 ( @entity1 ), and the amount of intra-operative @entity7 given. RESULTS: The median PAED scale scores did not differ between Groups B and NB at 30  min (P  =  0.41). @entity1 scores also did not differ significantly between the groups, but the mean amount of intraoperative @entity7 given was significantly lower in Group B than in Group NB (P  <  0.01). CONCLUSIONS: Ultrasound-guided II/IH @entity5 for ambulatory pediatric @entity2 did not reduce @entity6 , but it did decrease the amount of intra-operative @entity7 needed. CLINICAL TRIAL REGISTRATION: UMIN000008586.

title: Ultrasound-guided ilioinguinal/iliohypogastric block did not reduce emergence XXXX after ambulatory pediatric @entity2 : a prospective randomized double-blind study.

answer: @entity6


abstract: INTRODUCTION: In blunt @entity5 , lesions of the small bowell and mesentery are often underdiagnosed; although unusual, they represent the third most injured organ, with increasing morbidity and mortality. PRESENTATION OF CASE: The authors present the case of a 68 years old male, admitted to the emergency department after being hit by a bale of straw, weighing around 300kg, in the abdomen. After successful ressuscitation, a CT scan was performed, suggesting hemoperitoneum because of vascular lesion of the right colon @entity3 . An exploratory laparotomy was performed, confirming the presence of blood in the abdominal cavity and identifying jejunal perforation, an apparently innocent @entity4 of the small bowel mesentery (beside the bowel wall) distally to the first lesion and a laceration of the sigmoid serosa; a segmental jejunal resection and suture of the colon serosa were performed. In the early post-operative period, an enteric discharge was noticed, mandating surgical reexploration; a previously unnoticed bowel perforation, in the mesenteric border where the @entity4 was identified, justified an additional enterectomy, after what the @entity0 recovery progressed uneventfully. DISCUSSION: In this case, a sudden increase in abdominal pressure could explain that missed rupture of the mesenteric border of the jejunum, also causing the mesenteric @entity4 , or, in spite of that, a state of low perfusion could have lead to total wall @entity1 of an already irrigation compromised segment. Only noted after surgical exploration, despite prior evaluation with a computed tomography. Small bowell and @entity2 are potentially missed due to decreased exploratory laparotomies for blunt @entity5 . CONCLUSION: Although uncommon, small bowel and @entity2 are associated with high morbidity and mortality. High clinical suspicion is essential for an early diagnosis.

title: Small bowell perforation and @entity2 after an unusual blunt XXXX -Case report.

answer: @entity5


abstract: INTRODUCTION: In blunt @entity5 , lesions of the small bowell and mesentery are often underdiagnosed; although unusual, they represent the third most injured organ, with increasing morbidity and mortality. PRESENTATION OF CASE: The authors present the case of a 68 years old male, admitted to the emergency department after being hit by a bale of straw, weighing around 300kg, in the abdomen. After successful ressuscitation, a CT scan was performed, suggesting hemoperitoneum because of vascular lesion of the right colon @entity3 . An exploratory laparotomy was performed, confirming the presence of blood in the abdominal cavity and identifying jejunal perforation, an apparently innocent @entity4 of the small bowel mesentery (beside the bowel wall) distally to the first lesion and a laceration of the sigmoid serosa; a segmental jejunal resection and suture of the colon serosa were performed. In the early post-operative period, an enteric discharge was noticed, mandating surgical reexploration; a previously unnoticed bowel perforation, in the mesenteric border where the @entity4 was identified, justified an additional enterectomy, after what the @entity0 recovery progressed uneventfully. DISCUSSION: In this case, a sudden increase in abdominal pressure could explain that missed rupture of the mesenteric border of the jejunum, also causing the mesenteric @entity4 , or, in spite of that, a state of low perfusion could have lead to total wall @entity1 of an already irrigation compromised segment. Only noted after surgical exploration, despite prior evaluation with a computed tomography. Small bowell and @entity2 are potentially missed due to decreased exploratory laparotomies for blunt @entity5 . CONCLUSION: Although uncommon, small bowel and @entity2 are associated with high morbidity and mortality. High clinical suspicion is essential for an early diagnosis.

title: Small bowell perforation and XXXX after an unusual blunt @entity5 -Case report.

answer: @entity2


abstract: @entity6 ( @entity6 ) is characterized by @entity4 . A total of 146 @entity0 with @entity6 , were recruited. @entity6 severity was determined using Doppler imaging (E/Em) and also cardiac magnetic resonance imaging (CMRI). @entity3 modeling of @entity6 was induced by aortic banding. Hemodynamic and echocardiographic data were obtained before and after pressure loading and myocardial @entity7 was determined. Mechanical stretch of cultured cardiomyocytes served as the cellular model of @entity6 . @entity0 with severe @entity6 had significantly higher plasma @entity7 levels. Significant correlation between plasma @entity7 and E/Em in advanced @entity6 @entity0 was noted. After 2 weeks of pressure overload in @entity3 models, the protein expression of @entity7 from LV myocardial tissue was significantly increased (p   <   0.01) compared with controls. @entity7 expression paralleled the severity of LV @entity1 by evaluation of CMRI (r   =   -0.58, p   =   0.003) and tissue @entity2 (r   =   0.59, p   =   0.002). After adjusting for confounders for @entity1 , @entity7 levels were still associated with diastolic parameters both in @entity0 (p   <   0.001) and @entity3 model (p   =   0.041). Mechanical stretch increased @entity7 secretion in cultured cardiomyocytes. Both plasma and myocardial @entity7 levels correlated with severity of @entity5 .

title: XXXX level and the severity of @entity5 using cellular and animal models and clinical indices.

answer: @entity7


abstract: @entity6 ( @entity6 ) is characterized by @entity4 . A total of 146 @entity0 with @entity6 , were recruited. @entity6 severity was determined using Doppler imaging (E/Em) and also cardiac magnetic resonance imaging (CMRI). @entity3 modeling of @entity6 was induced by aortic banding. Hemodynamic and echocardiographic data were obtained before and after pressure loading and myocardial @entity7 was determined. Mechanical stretch of cultured cardiomyocytes served as the cellular model of @entity6 . @entity0 with severe @entity6 had significantly higher plasma @entity7 levels. Significant correlation between plasma @entity7 and E/Em in advanced @entity6 @entity0 was noted. After 2 weeks of pressure overload in @entity3 models, the protein expression of @entity7 from LV myocardial tissue was significantly increased (p   <   0.01) compared with controls. @entity7 expression paralleled the severity of LV @entity1 by evaluation of CMRI (r   =   -0.58, p   =   0.003) and tissue @entity2 (r   =   0.59, p   =   0.002). After adjusting for confounders for @entity1 , @entity7 levels were still associated with diastolic parameters both in @entity0 (p   <   0.001) and @entity3 model (p   =   0.041). Mechanical stretch increased @entity7 secretion in cultured cardiomyocytes. Both plasma and myocardial @entity7 levels correlated with severity of @entity5 .

title: @entity7 level and the severity of XXXX using cellular and animal models and clinical indices.

answer: @entity5


abstract: PURPOSE: To report long-term follow-up of zonulo-hyaloido-vitrectomy (ZHV) via anterior approach for pseudophakic @entity1 refractory to medical treatment. DESIGN: Noncomparative case-series. MATERIALS AND METHODS: Medical records of 9 @entity0 who sought treatment for @entity2 misdirection refractory to medical treatment were reviewed. All @entity0 underwent anterior vitrectomy, hyaloido-zonulectomy, and peripheral iridectomy (PI) via an anterior approach. Main outcome measures were preoperative and postoperative visual acuity, intraocular pressure, medications, slit-lamp examination, and fundus    ndings. RESULTS: 10 eyes of 9 @entity0 (7 female, 2 male) who underwent ZHV for refractory pseudophakic @entity1 between 2003 and 2010 were included in this case-series. The mean age of @entity0 was 77.4    9.0 years, mean follow-up duration 50.2    27.2 months. Recurrence of @entity1 was noted in 40% (four cases) after a successful ZHV on long-term follow-up. CONCLUSIONS: An anterior segment surgeon can treat @entity1 refractory to medical treatment successfully by vitrectomy, hyaloido-zonulectomy, and PI. This can be done via an anterior approach and @entity0 require long follow-up to rule out a relapse despite a successful outcome in the short term.

title: Long-term follow-up of zonulo-hyaloido-vitrectomy for pseudophakic XXXX .

answer: @entity1


abstract: OBJECTIVE: To determine the safety, clinical outcome, and @entity4 rate of femoropopliteal interventions using 4F stents. METHODS: Between January 2010 and December 2011, 112 symptomatic @entity0 were treated by stent implantation. Ten @entity0 were lost to follow up; therefore, 102 @entity0 (62 @entity0 ; mean age 66.4      10.1  years) were retrospectively analyzed. The indication for femoropopliteal revascularization was severe @entity6 (Rutherford-Becker score  =  3) in 63 (62%) @entity0 and chronic @entity2 (Rutherford-Becker score  =  4-6) in 39 (38%). Follow up included palpation of peripheral pulses and measurement of ankle brachial index. In @entity0 with suspected in-stent restenosis duplex ultrasonography was performed. In 2013, @entity0 were asked to return for a fluoroscopic examination of the stents. RESULTS: 114 lesions (Trans-Atlantic InterSociety Consensus-C and D, n  =  45) were treated with 119 stents (Astron Pulsar, n  =  42; Pulsar-18, n  =  77). Lesions were long (>= 100  mm) in 49 cases and heavily calcified in 35. Stents were long (>= 120  mm) in 46 cases. Ten stents were partially overlapped. The technical and clinical success rates were 100%. Two puncture related complications were noted, neither of which required surgical repair. Eleven @entity0 died ( @entity5 , n  =  4; @entity3 , n  =  2; @entity1 , n  =  5) and nine @entity0 underwent major amputation (above knee, n  =  4). The primary patency rate was 83% at 6 months and 80% at 12 months. The primary assisted patency rate was 97% at 6 months and 94% at 12 months. The secondary patency rate was 86% at 6 months and 85% at 12 months. The prevalence of @entity4 was 26% (type III and IV, 10%) after an average follow up of 25 months. CONCLUSION: Femoropopliteal stenting using a 4F compatible delivery system can be accomplished with a low complication rate, acceptable @entity4 rate, and with similar 12 month patency and revascularization rates as their 6F counterparts.

title: Safety, Clinical Outcome, and XXXX Rate of Femoropopliteal Stenting Using a 4F Compatible Delivery System.

answer: @entity4


abstract: BACKGROUND: The solid variant of @entity5 (SVPTC) comprises approximately 3% of @entity3 , and there are conflicting reports about its behavior in the literature. The cytology of SVPTC is limited to 3 single case reports, a review article, and a monograph. We present the first cytologic study of SVPTC. METHODS: Fine-needle aspiration smears obtained with ultrasound guidance from 13 @entity0 with histologically pure SVPTC were reviewed, and the cytologic features recorded. Ultrasound images were retrieved from radiology and were correlated with low-power histology images. Intratumor vascularity on Doppler imaging was correlated with cellularity in cytology samples. RESULTS: Three cytomorphologic patterns of SVPTC were identified: cohesive, syncytial-type tissue fragments; microfollicles/trabeculae; and dyshesive single cells. @entity6 SVPTCs in the first group were encapsulated without invasion. Two of 6 SVPTCs in the second group had a single lymph node @entity1 ; 4 were encapsulated, and 2 had pushing borders. Ultrasound images in the first and second SVPTC groups were similar, with the majority revealing a well defined, solid nodule with minimal intranodular vascularity. All 4 SVPTCs in the third group had infiltrative borders; and, with the exception of one 0.8-cm @entity2 , all had multiple lymph node @entity1 . Ultrasound in the third group revealed irregular borders. @entity7 / @entity4 and @entity7 / @entity8 mutations were found in 2 cases of the third group. CONCLUSIONS: SVPTCs are heterogeneous @entity2 . The cohesive, syncytial tissue-fragment pattern can be recognized as SVPTC in smears and is associated with encapsulation and indolent behavior. The microfollicular/trabecular pattern is indistinguishable from that of the follicular variant of @entity5 and has intermediate behavior. The dyshesive single-cell pattern correlates with infiltrative @entity2 growth and may not be unique to SVPTC. @entity2 ( @entity2 Cytopathol) 2015.    2015 American @entity2 Society.

title: Fine-needle aspiration cytology of the solid variant of XXXX : A study of 13 cases with clinical, histologic, and ultrasound correlations.

answer: @entity5


abstract: UNASSIGNED: Background: Some cases of @entity2 tend to be diagnosed as @entity1 ( @entity1 ) based on elevated levels of immunoglobulin E (IgE) and thymus and activation-regulated chemokine ( @entity3 ). However, there are few studies that describe the detailed characteristics of @entity1 . Objective: We examined the association of @entity2 with @entity1 . Methods: In this retrospective observational study, 68 @entity0 over 65 years of age who presented with @entity2 at Osaka University Hospital were enrolled. @entity0 data were collected through medical records and descriptive statistics. Results: 47% of the @entity0 were classified as having idiopathic @entity2 and 53% as having secondary @entity2 . In both idiopathic and secondary @entity2 patients, serum IgE and @entity3 levels were elevated. 84% of idiopathic @entity2 @entity0 fulfilled the Japanese Dermatological Associations criteria for @entity1 ; however, only 4 @entity0 were finally definitely diagnosed with @entity1 . Conclusion: Many @entity2 @entity0 showed @entity1 -like symptoms due to T helper 2 polarization.    2015 S. Karger AG, Basel.

title: T Helper 2 Polarization in Senile Erythroderma with Elevated Levels of XXXX and IgE.

answer: @entity3


abstract: BACKGROUND AND PURPOSE: @entity4 is an @entity1 that presents in 10%-20% of @entity0 with various @entity5 . We aimed to report the radiologic features (phenotype) and the genotype-phenotype correlations of @entity5 in @entity4 . MATERIALS AND METHODS: Demographic, clinical, genotypic, and imaging information of 75 @entity0 with @entity4 with @entity6 enrolled in the @entity5 Consortium from 2010 to 2012 were reviewed. RESULTS: Nonshunting, small, superficially located conglomerates of enhancing vessels without enlarged feeding arteries or draining veins called " @entity3 " were the most commonly observed lesion (46 of 75 @entity0 ; 61%), followed by shunting "nidus-type" brain AVMs that were typically located superficially with a low Spetzler-Martin Grade and a small size (32 of 75 @entity0 ; 43%). Direct high-flow fistulous arteriovenous shunts were present in 9 @entity0 (12%). Other types of @entity3 ( @entity2 ) were present in 1 @entity0 each. @entity3 was seen in 33 cases (44%). No statistically significant correlation was observed between @entity4 gene mutation and lesion type or lesion multiplicity. CONCLUSIONS: Depending on their imaging features, @entity5 in @entity4 can be subdivided into brain AVF, nidus-type AVM, and @entity3 , with the latter being the most common phenotype in @entity4 . No genotype-phenotype correlation was observed among @entity0 with this condition.

title: Neurovascular manifestations in XXXX : imaging features and genotype-phenotype correlations.

answer: @entity4


abstract: UNASSIGNED: Background: This study analyzed the @entity0 survival outcomes following the resection of @entity2 ( @entity2 ) metachronous adrenal metastasis (MAM) in @entity0 who had undergone liver resection or liver transplantation (LT). Methods: Clinical results were analyzed retrospectively in 26 @entity0 with MAM- @entity2 who underwent adrenalectomy. Results: The mean interval between initial surgery and adrenalectomy was significantly shorter in the resection group than in the LT group (18.3    14.4 vs. 42.6    13.8 months, p < 0.001). Of 19 resected @entity0 , four had adrenal metastases on the right side, 12 on the left side and three bilaterally, with a mean @entity1 diameter of 3.6    1.5 cm. Ten of these @entity0 underwent open surgery and nine underwent laparoscopic surgery; all @entity0 experienced @entity3 within 18 months and 20.3% survived 5 years after adrenalectomy. Of 7 @entity0 who underwent LT, four had adrenal metastases on the right side and three on the left side, with a mean @entity1 diameter of 3.4    1.8 cm. Six of these @entity0 underwent open surgery and one underwent laparoscopic surgery. Five-year recurrence and @entity0 survival rates after adrenalectomy were 28.6 and 85.7%, respectively. Conclusions: Adrenalectomy is indicated in @entity0 with isolated MAM- @entity2 . Comparisons with other locoregional treatment modalities and multicenter studies with additional @entity0 are needed to validate the role of adrenalectomy.    2015 S. Karger AG, Basel.

title: Resection of Metachronous Adrenal Metastasis after Liver Resection and Transplantation for XXXX .

answer: @entity2


abstract: Seventy-three @entity0 were operated on for confirmed @entity8 . Identification of all glands was done by 1/3 biopsies for histopathologic examination on frozen section during the operation. In cases of @entity4 only, the @entity4 was removed except for the biopsies. In cases of @entity5 , subtotal resection was made, leaving between a half-gland and a whole gland. The frequency of complications was analysed. Temporary @entity9 occurred in a similar frequency in both @entity4 and @entity5 groups. Permanent @entity9 was present in only one @entity0 . At follow-up 3-5 years after operation, 98.6% of the @entity0 were normocalcemic. Ionized and total serum @entity2 were normalized 3 months after operation and remained so for the rest of the follow-up period. Serum @entity6 , serum @entity7 and serum @entity10 also remained normal. Thus identification of parathyroid glands with biopsies or @entity3 in cases with @entity5 did not increase the risk of @entity1 .

title: Complications to XXXX .

answer: @entity3


abstract: OBJECTIVE: To explore the therapeutic efficacy of allo-geneic hematopoietic stem cell transplantation (allo-HSCT) for @entity8 ( @entity8 ) @entity0 with @entity14 mutation. METHODS: Retrospective analyses were conducted for 4 @entity0 with @entity14 mutation of @entity8 undergoing allo-HSCT from June 2012 to January 2014, including 2 cases in acceleration phase and 2 in chronic phase. There were 2 males and 2 females with ages from 26 to 45 years. Two @entity0 received HLA-matched sibling allo-geneic peripheral blood stem cell transplantation (allo-PBSCT) while another 2 unrelated cord blood stem cell transplantation (UCBT). No @entity3 was found before transplantation. One case had @entity13 mutation. All of them were treated with @entity12 before transplantation. And the time from medication to @entity14 mutation was 20-35 months. All of them were conditioned with myeloablative regimen and received a combination of @entity1 ( @entity6 ) and @entity4 ( @entity10 ) for preventing @entity11 ( @entity11 ). RESULTS: Myeloid implantation was achieved in all of them. The time of absolute neutrophil count (ANC) >=  0.5*10(9)/L were 10-28 days. One @entity0 whose platelet was not implanted died from severe @entity2 at Day 88 post-transplantation. For 3 @entity0 , platelet >=  20*10(9)/L were 15-33 days. But the marrow short tandem repeat (STR)-PCR was 100% donor type at the time of 30 days post-transplantation in all @entity0 . One case of UCBT developed pre-implantation immune response syndrome (PES) and one acute @entity11 of gradeI at Day 12 after allo-PBSCT. However both were controlled after treatment with @entity7 . @entity5 /3 evaluatable @entity0 developed chronic @entity11 . @entity9 transcript was detected by qualitative PCR after transplantation. And all @entity9 fusion genes turned negative after 30 days of transplantation. Up to the follow-up endpoint, there was no relapse except for one mortality. And the time of disease-free survival was 133, 248 and 704 days respectively. CONCLUSIONS: Allo-HSCT is currently the optimal treatment for @entity14 mutation of @entity8 . And umbilical cord blood is an ideal donor for those @entity0 without HLA-matched sibling donor.

title: [Allo-geneic hematopoietic stem cell transplantation in treatment with @entity14 mutation of XXXX ].

answer: @entity8


abstract: OBJECTIVE: To explore the therapeutic efficacy of allo-geneic hematopoietic stem cell transplantation (allo-HSCT) for @entity8 ( @entity8 ) @entity0 with @entity14 mutation. METHODS: Retrospective analyses were conducted for 4 @entity0 with @entity14 mutation of @entity8 undergoing allo-HSCT from June 2012 to January 2014, including 2 cases in acceleration phase and 2 in chronic phase. There were 2 males and 2 females with ages from 26 to 45 years. Two @entity0 received HLA-matched sibling allo-geneic peripheral blood stem cell transplantation (allo-PBSCT) while another 2 unrelated cord blood stem cell transplantation (UCBT). No @entity3 was found before transplantation. One case had @entity13 mutation. All of them were treated with @entity12 before transplantation. And the time from medication to @entity14 mutation was 20-35 months. All of them were conditioned with myeloablative regimen and received a combination of @entity1 ( @entity6 ) and @entity4 ( @entity10 ) for preventing @entity11 ( @entity11 ). RESULTS: Myeloid implantation was achieved in all of them. The time of absolute neutrophil count (ANC) >=  0.5*10(9)/L were 10-28 days. One @entity0 whose platelet was not implanted died from severe @entity2 at Day 88 post-transplantation. For 3 @entity0 , platelet >=  20*10(9)/L were 15-33 days. But the marrow short tandem repeat (STR)-PCR was 100% donor type at the time of 30 days post-transplantation in all @entity0 . One case of UCBT developed pre-implantation immune response syndrome (PES) and one acute @entity11 of gradeI at Day 12 after allo-PBSCT. However both were controlled after treatment with @entity7 . @entity5 /3 evaluatable @entity0 developed chronic @entity11 . @entity9 transcript was detected by qualitative PCR after transplantation. And all @entity9 fusion genes turned negative after 30 days of transplantation. Up to the follow-up endpoint, there was no relapse except for one mortality. And the time of disease-free survival was 133, 248 and 704 days respectively. CONCLUSIONS: Allo-HSCT is currently the optimal treatment for @entity14 mutation of @entity8 . And umbilical cord blood is an ideal donor for those @entity0 without HLA-matched sibling donor.

title: [Allo-geneic hematopoietic stem cell transplantation in treatment with XXXX mutation of @entity8 ].

answer: @entity14


abstract: BACKGROUND: Little is known about the degree of articular cartilage degeneration after subtotal/total lateral meniscectomy in @entity0 who later undergo isolated @entity1 ( @entity1 ). It has not yet been studied whether arthritic changes as shown on radiographs were lower during the posttransplantation period than during the meniscus-deficient period. HYPOTHESIS: Articular cartilage will significantly degenerate during the meniscus-deficient period, but the progression in radiographic @entity2 is reduced after @entity1 . STUDY DESIGN: Case series; Level of evidence, 4. METHODS: This study retrospectively reviewed 49 @entity0 who underwent subtotal/total lateral meniscectomy before isolated @entity1 performed over 1 year later by the same surgeon. International Cartilage Repair Society (ICRS) grades of the femorotibial joint at the time of subtotal/total meniscectomy and at @entity1 were compared. Radiographic evaluation was performed at the time of initial meniscectomy, @entity1 , and the latest follow-up in 38 @entity0 (after 11 @entity0 whose radiographs showed incomplete ossification at the time of meniscectomy were excluded). @entity2 , based on Kellgren-Lawrence (K-L) grades, was determined on standing anteroposterior views. Joint space width (JSW) was measured on weightbearing flexion posteroanterior views. RESULTS: Over a mean meniscus-deficient period of 4.5 years (range, 1-13 years), articular cartilage significantly degenerated on the femoral and tibial sides (P < .001). Grade >= 3 degeneration on the lateral tibial plateau was observed in 13 @entity0 (27%) at the time of initial meniscectomy; this incidence doubled to 28 @entity0 (57%) by the time of @entity1 . The K-L grades worsened (P < .001) and JSWs narrowed significantly (-0.65    1.09 mm; P = .001) during the mean meniscus-deficient period of 3.1 years. At radiographic assessment, however, the K-L grades (P = .097) and JSWs (4.06    1.19 vs 3.92    1.21 mm; mean difference, -0.14    0.68 mm; P = .213) did not significantly change during the mean posttransplantation period of 3.8 years. The changes in ICRS grade and JSW during the meniscus-deficient period were not associated with age, body mass index, mechanical axis deviation, or Tegner activity level (P > .05 for all relationships). CONCLUSION: @entity0 who underwent isolated @entity1 showed substantial articular cartilage degeneration at the time of initial subtotal/total lateral meniscectomy, and this degeneration progressed thereafter. Further progression of radiographic @entity2 was delayed after @entity1 .

title: Articular Cartilage Degenerates After Subtotal/Total Lateral Meniscectomy but Radiographic XXXX Progression Is Reduced After Meniscal Transplantation.

answer: @entity2


abstract: UNASSIGNED: Background. Recently, combined intra-articular @entity3 (IA- @entity4 ) injection with clamping drain method showed efficacy for @entity1 and transfusion reduction in total knee replacement (TKR). However, until now, none of previous studies revealed the effect of this technique on pharmacokinetics, coagulation, and fibrinolysis. Materials and Methods. An experimental study was conducted, during 2011-2012, in 30 @entity0 undergoing unilateral TKR. @entity0 received IA- @entity4 application and then were allocated into six groups regarding clamping drain duration (2-, 4-, 6-, 8-, 10-, and 12-hours). Blood and drainage fluid were collected to measure @entity3 ( @entity4 ) level and @entity5 and fibrinolytic markers. @entity2 was followed for one year. Results. There was no significant difference of serum @entity4 level at 2 hour and 24 hour among groups (p < 0.05). Serum @entity4 level at time of clamp release was significantly different among groups with the highest level at 2 hour (p < 0.0001). There was no significant difference of @entity4 level in drainage fluid, postoperative @entity1 , blood transfusion, and @entity2 (p < 0.05).      Conclusions. Low-dose IA- @entity4 application in TKR with prolonged clamping drain method is a safe and effective blood conservative technique with only minimal systemic absorption and without significant increase in systemic absorption over time.

title: An In Vivo Study of Low-Dose Intra-Articular XXXX Application with Prolonged Clamping Drain Method in Total Knee Replacement: Clinical Efficacy and Safety.

answer: @entity3


abstract: UNASSIGNED: Aims. @entity0 action potentials in the @entity2 have been characterized by delayed or even complete loss of dome formation, especially in the right @entity1 . Such a repolarization pattern is believed to trigger phase-2 reentry (P2R); however, little is known about the conditions necessary for its initiation. This study aims to determine the specific mechanisms that facilitate P2R induction in Brugada-affected cardiac tissue in @entity0 . Methods. Ionic models for @entity2 in @entity0 epicardial cells were developed and used to study the induction of P2R in cables, sheets, and a three-dimensional model of the right ventricular free wall. Results. In one-dimensional cables, P2R can be induced by adjoining lost-dome and delayed-dome regions, as mediated by tissue excitability and transmembrane voltage profiles, and reduced coupling facilitates its induction. In two and three dimensions, sustained reentry can arise when three regions (delayed-dome, lost-dome, and normal epicardium) are present. Conclusions. Not only does P2R induction by @entity2 require regions of action potential with delayed-dome and lost-dome, but in order to generate a sustained reentry from a triggered waveback multiple factors are necessary, including heterogeneity in action potential distribution, tissue coupling, direction of stimulation, the shape of the late plateau, the duration of lost-dome action potentials, and recovery of tissue excitability, which is predominantly modulated by tissue coupling.

title: Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the XXXX .

answer: @entity2


abstract: UNASSIGNED: We developed a new @entity9 coating technology for @entity6 hip implants and performed a clinical trial to assess its usefulness in suppressing @entity1 . Results indicate that @entity7 -supported @entity6 has favorable antibacterial activity, biocompatibility, and no @entity2 . Thirty joints in 28 @entity0 were treated using @entity7 -supported implants. Fourteen joints were revision @entity4 ( @entity4 ) after @entity3 , 13 were primary @entity4 for immunosuppressive conditions or @entity5 , and 3 were conversions from hemiarthroplasty to @entity4 for immunosuppressive conditions. Two examinations were conducted sequentially until final follow-up: white blood cell (WBC) and @entity8 ( @entity8 ) were measured pre- and postoperatively and thyroid hormone levels in the blood were examined. The mean follow-up period was 33 months (14-78). There were no signs of @entity3 in any @entity0 at the last follow-up. WBC and @entity8 levels returned to normal within several weeks. No abnormalities of thyroid gland function were detected. Loosening of the implants did not occur in any @entity0 . Excellent bone ingrowth and ongrowth were found around prostheses. No @entity2 or adverse effects were detected. These results suggest that @entity7 -supported @entity4 implants can be highly effective in preventing and treating @entity1 .

title: XXXX -Supported Hip Implants: Short Term Clinical Results.

answer: @entity7


abstract: STUDY DESIGN: Retrospective chart review. OBJECTIVE: To determine the efficacy of adjuvant cryotherapy in the treatment of early @entity1 and @entity4 . SUMMARY OF BACKGROUND DATA: The use of cryotherapy in conjunction with traditional modalities has recently been proposed to improve voice outcomes in @entity0 with early @entity1 as compared to pretreatment conditions. This study investigates its utility in improving oncological outcomes and decreasing recurrences of @entity4 . METHODS: @entity0 with either early @entity1 or @entity4 that received cryotherapy as part of their surgical regimen were investigated. All @entity0 were seen at a large tertiary care center within a 10-year window. Demographic data were collected and all postoperative notes were reviewed. Recurrences of the @entity1 were noted, as was the duration of time between successive @entity3 operations. RESULTS: The charts of 54 @entity1 and 29 @entity3 @entity0 that received cryotherapy were reviewed. One @entity0 from the @entity3 cohort was excluded from statistical analysis due to lack of follow-up. Overall, 16 (30%) of the @entity1 @entity0 experienced a malignant recurrence. The overall 5-year survival of these @entity0 was 98% and the 5-year disease-free survival was 74%. The use of adjuvant cryotherapy in the treatment of @entity4 extended the duration of time between surgeries by an average of 79 days (P = .23). CONCLUSION: The use of adjuvant cryotherapy in the treatment of early @entity1 does not improve the rate of @entity2 recurrences. Additionally, cryotherapy does not result in a statistically significant increase in the duration of disease-free period for @entity4 @entity0 , although the observed increase may be clinically important.

title: The Use of Cryotherapy for XXXX and Early Laryngeal Cancers: Long-term Results.

answer: @entity3


abstract: UNASSIGNED: We aimed to study factors influencing outcomes of adults hospitalised for seasonal and pandemic @entity4 .   Individual- @entity0 data from three Asian cohorts (Hong Kong, Singapore and Beijing; N=2649) were analysed. Adults hospitalised for laboratory-confirmed @entity4 (prospectively diagnosed) during 2008-2011 were studied. The primary outcome measure was 30-day survival. Multivariate Cox regression models (time-fixed and time-dependent) were used. @entity0 had high morbidity (respiratory/nonrespiratory complications in 68.4%, @entity8 in 48.6%, @entity1 in 40.8% and bacterial superinfections in 10.8%) and mortality (5.9% at 30   days and 6.9% at 60   days). 75.2% received @entity7 inhibitors ( @entity9 ) (73.8% received @entity5 and 1.4% received @entity10 / @entity6 ; 44.5% of @entity0 received @entity9    2   days and 65.5%    5   days after onset of illness); 23.1% received systemic @entity3 . There were fewer @entity2 among @entity9 -treated @entity0 (5.3% versus 7.6%; p=0.032). @entity9 treatment was independently associated with survival (adjusted hazard ratio (HR) 0.28, 95% CI 0.19-0.43), adjusted for treatment-propensity score and @entity0 characteristics. Superinfections increased (adjusted HR 2.18, 95% CI 1.52-3.11) and chronic statin use decreased (adjusted HR 0.44, 95% CI 0.23-0.84) death risks. Best survival was shown when treatment started within    2   days (adjusted HR 0.20, 95% CI 0.12-0.32), but there was benefit with treatment within 3-5   days (adjusted HR 0.35, 95% CI 0.21-0.58). Time-dependent analysis showed consistent results of @entity9 treatment (adjusted HR 0.39, 95% CI 0.27-0.57). @entity3 increased superinfection (9.7% versus 2.7%) and @entity2 when controlled for indications (adjusted HR 1.73, 95% CI 1.14-2.62). Early @entity9 treatment was associated with shorter length of stay in a subanalysis. @entity9 treatment may improve survival of hospitalised @entity4 @entity0 ; benefit is greatest from, but not limited to, treatment started within 2   days of illness. Superinfections and @entity3 increase mortality. Antiviral and non-antiviral management strategies should be considered.

title: XXXX inhibitors, superinfection and @entity3 affect survival of @entity4 @entity0 .

answer: @entity7


abstract: UNASSIGNED: We aimed to study factors influencing outcomes of adults hospitalised for seasonal and pandemic @entity4 .   Individual- @entity0 data from three Asian cohorts (Hong Kong, Singapore and Beijing; N=2649) were analysed. Adults hospitalised for laboratory-confirmed @entity4 (prospectively diagnosed) during 2008-2011 were studied. The primary outcome measure was 30-day survival. Multivariate Cox regression models (time-fixed and time-dependent) were used. @entity0 had high morbidity (respiratory/nonrespiratory complications in 68.4%, @entity8 in 48.6%, @entity1 in 40.8% and bacterial superinfections in 10.8%) and mortality (5.9% at 30   days and 6.9% at 60   days). 75.2% received @entity7 inhibitors ( @entity9 ) (73.8% received @entity5 and 1.4% received @entity10 / @entity6 ; 44.5% of @entity0 received @entity9    2   days and 65.5%    5   days after onset of illness); 23.1% received systemic @entity3 . There were fewer @entity2 among @entity9 -treated @entity0 (5.3% versus 7.6%; p=0.032). @entity9 treatment was independently associated with survival (adjusted hazard ratio (HR) 0.28, 95% CI 0.19-0.43), adjusted for treatment-propensity score and @entity0 characteristics. Superinfections increased (adjusted HR 2.18, 95% CI 1.52-3.11) and chronic statin use decreased (adjusted HR 0.44, 95% CI 0.23-0.84) death risks. Best survival was shown when treatment started within    2   days (adjusted HR 0.20, 95% CI 0.12-0.32), but there was benefit with treatment within 3-5   days (adjusted HR 0.35, 95% CI 0.21-0.58). Time-dependent analysis showed consistent results of @entity9 treatment (adjusted HR 0.39, 95% CI 0.27-0.57). @entity3 increased superinfection (9.7% versus 2.7%) and @entity2 when controlled for indications (adjusted HR 1.73, 95% CI 1.14-2.62). Early @entity9 treatment was associated with shorter length of stay in a subanalysis. @entity9 treatment may improve survival of hospitalised @entity4 @entity0 ; benefit is greatest from, but not limited to, treatment started within 2   days of illness. Superinfections and @entity3 increase mortality. Antiviral and non-antiviral management strategies should be considered.

title: @entity7 inhibitors, superinfection and @entity3 affect survival of XXXX @entity0 .

answer: @entity4


abstract: UNASSIGNED: We aimed to study factors influencing outcomes of adults hospitalised for seasonal and pandemic @entity4 .   Individual- @entity0 data from three Asian cohorts (Hong Kong, Singapore and Beijing; N=2649) were analysed. Adults hospitalised for laboratory-confirmed @entity4 (prospectively diagnosed) during 2008-2011 were studied. The primary outcome measure was 30-day survival. Multivariate Cox regression models (time-fixed and time-dependent) were used. @entity0 had high morbidity (respiratory/nonrespiratory complications in 68.4%, @entity8 in 48.6%, @entity1 in 40.8% and bacterial superinfections in 10.8%) and mortality (5.9% at 30   days and 6.9% at 60   days). 75.2% received @entity7 inhibitors ( @entity9 ) (73.8% received @entity5 and 1.4% received @entity10 / @entity6 ; 44.5% of @entity0 received @entity9    2   days and 65.5%    5   days after onset of illness); 23.1% received systemic @entity3 . There were fewer @entity2 among @entity9 -treated @entity0 (5.3% versus 7.6%; p=0.032). @entity9 treatment was independently associated with survival (adjusted hazard ratio (HR) 0.28, 95% CI 0.19-0.43), adjusted for treatment-propensity score and @entity0 characteristics. Superinfections increased (adjusted HR 2.18, 95% CI 1.52-3.11) and chronic statin use decreased (adjusted HR 0.44, 95% CI 0.23-0.84) death risks. Best survival was shown when treatment started within    2   days (adjusted HR 0.20, 95% CI 0.12-0.32), but there was benefit with treatment within 3-5   days (adjusted HR 0.35, 95% CI 0.21-0.58). Time-dependent analysis showed consistent results of @entity9 treatment (adjusted HR 0.39, 95% CI 0.27-0.57). @entity3 increased superinfection (9.7% versus 2.7%) and @entity2 when controlled for indications (adjusted HR 1.73, 95% CI 1.14-2.62). Early @entity9 treatment was associated with shorter length of stay in a subanalysis. @entity9 treatment may improve survival of hospitalised @entity4 @entity0 ; benefit is greatest from, but not limited to, treatment started within 2   days of illness. Superinfections and @entity3 increase mortality. Antiviral and non-antiviral management strategies should be considered.

title: @entity7 inhibitors, superinfection and XXXX affect survival of @entity4 @entity0 .

answer: @entity3


abstract: UNASSIGNED: We aimed to study factors influencing outcomes of adults hospitalised for seasonal and pandemic @entity4 .   Individual- @entity0 data from three Asian cohorts (Hong Kong, Singapore and Beijing; N=2649) were analysed. Adults hospitalised for laboratory-confirmed @entity4 (prospectively diagnosed) during 2008-2011 were studied. The primary outcome measure was 30-day survival. Multivariate Cox regression models (time-fixed and time-dependent) were used. @entity0 had high morbidity (respiratory/nonrespiratory complications in 68.4%, @entity8 in 48.6%, @entity1 in 40.8% and bacterial superinfections in 10.8%) and mortality (5.9% at 30   days and 6.9% at 60   days). 75.2% received @entity7 inhibitors ( @entity9 ) (73.8% received @entity5 and 1.4% received @entity10 / @entity6 ; 44.5% of @entity0 received @entity9    2   days and 65.5%    5   days after onset of illness); 23.1% received systemic @entity3 . There were fewer @entity2 among @entity9 -treated @entity0 (5.3% versus 7.6%; p=0.032). @entity9 treatment was independently associated with survival (adjusted hazard ratio (HR) 0.28, 95% CI 0.19-0.43), adjusted for treatment-propensity score and @entity0 characteristics. Superinfections increased (adjusted HR 2.18, 95% CI 1.52-3.11) and chronic statin use decreased (adjusted HR 0.44, 95% CI 0.23-0.84) death risks. Best survival was shown when treatment started within    2   days (adjusted HR 0.20, 95% CI 0.12-0.32), but there was benefit with treatment within 3-5   days (adjusted HR 0.35, 95% CI 0.21-0.58). Time-dependent analysis showed consistent results of @entity9 treatment (adjusted HR 0.39, 95% CI 0.27-0.57). @entity3 increased superinfection (9.7% versus 2.7%) and @entity2 when controlled for indications (adjusted HR 1.73, 95% CI 1.14-2.62). Early @entity9 treatment was associated with shorter length of stay in a subanalysis. @entity9 treatment may improve survival of hospitalised @entity4 @entity0 ; benefit is greatest from, but not limited to, treatment started within 2   days of illness. Superinfections and @entity3 increase mortality. Antiviral and non-antiviral management strategies should be considered.

title: @entity7 inhibitors, superinfection and @entity3 affect survival of @entity4 XXXX .

answer: @entity0


abstract: Three groups of 4 @entity2 each were experimentally infected with an isolate of progressive @entity0 virus ( @entity3 ) by intracerebral, intra-articular, or intrathoracic routes of inoculation. An additional control group was sham-inoculated by all 3 routes with identically prepared, noninfected inoculum. @entity2 were killed 12 to 42 days after inoculation. A mild generalized @entity4 was found in 2 of the 4 @entity2 inoculated intracerebrally. A severe, @entity1 with massive infiltration of lymphocytes and plasma cells was found in the 4 @entity2 inoculated intraarticularly. Germinal center formation was found in the synovial membrane 42 days after inoculation. Appreciable differences in lung morphologic features were not observed among the 4 groups. The @entity3 was isolated from virus-inoculated @entity2 from the choroid plexus, synovium, and lungs from inoculated and noninoculated sites. Nine of the 12 virus-inoculated lambs developed serum antibody to @entity3 , and specific antibodies were found in the synovial fluid of virus-inoculated joints. Virus was not isolated, lesions were not found, and serum antibody was not demonstrated in sham-inoculated @entity2 .

title: Ovine progressive XXXX : experimental intrathoracic, intracerebral, and intra-articular infections.

answer: @entity0


abstract: UNASSIGNED: The interaction between cell surface glycans and extracellular matrix  (ECM) including galectins is known to be closely associated with @entity2 cell adhesion, invasion and @entity1 . We analyzed the roles of cell surface sialylation or glycosylation in galectin or ECM  -mediated cell adhesion and invasion of @entity0 @entity4 cells. @entity3 from Arthrobacter ureafaciens  (AU) treatment resulted in reduction of cell adhesion to @entity8 in @entity0 @entity5  (H  -ALCL) which was established in our laboratory. The knockdown of b  -galactoside a  -2,6  -sialyltrans-ferase  ( @entity7 ) by siRNA showed inhibition of @entity7 expression in the cytoplasm of H  -ALCL cells on immunohistochemical findings, and showed dramatic enhancement of cell adhesion to @entity8 . On the other hand, a  -2,3  -specific @entity3 treatment resulted in moderate enhancement of cell adhesion to @entity8 . We performed chemically artificial modification of cell surface O  -glycans by treatment of benzyl 2  -acetamido  -2  -deoxy  -a  -D  -galactopyranoside  (Bz  -a  -GalNAc) in H  -ALCL. Cell adhesion to @entity8 was enhanced by treatment of Bz  -a  -GalNAc suggesting that inhibition of elongation of O  -glycans may enhance cell adhesion to @entity8 in H  -ALCL cells. On the other hand inhibition of elongation of N  -glycosylation by tunicamycin  (TM) resulted in inhibition of @entity6  (L  -PHA) lectin  -binding activity and inhibited cell adhesion to @entity8 , laminin and fibronectin. @entity3 treatment enhanced cell adhesion to laminin, and knockdown of @entity7 resulted in enhancement of cell adhesion to laminin, but not to fibronectin, collagen type  1  and  4. @entity8 pre  -treatment dramatically enhanced cell adhesion to laminin and @entity3 treatment also enhanced cell adhesion to laminin in combination with @entity8 . Rho inhibitor, C3  -transferase pre  -treatment resulted in inhibition of cell invasion to @entity8 . Phosphatidylinositol  3  -phosphate kinase  (PI3K) inhibitor, wortmannin inhibits the cell invasive capacity to @entity8 . @entity3 treatment induces growth inhibition of @entity4 cells by @entity8 .

title: Sialylation by b  -galactoside a  -2,6  -sialyltransferase and N  -glycans regulate cell adhesion and invasion in @entity0 XXXX .

answer: @entity5


abstract: UNASSIGNED: The interaction between cell surface glycans and extracellular matrix  (ECM) including galectins is known to be closely associated with @entity2 cell adhesion, invasion and @entity1 . We analyzed the roles of cell surface sialylation or glycosylation in galectin or ECM  -mediated cell adhesion and invasion of @entity0 @entity4 cells. @entity3 from Arthrobacter ureafaciens  (AU) treatment resulted in reduction of cell adhesion to @entity8 in @entity0 @entity5  (H  -ALCL) which was established in our laboratory. The knockdown of b  -galactoside a  -2,6  -sialyltrans-ferase  ( @entity7 ) by siRNA showed inhibition of @entity7 expression in the cytoplasm of H  -ALCL cells on immunohistochemical findings, and showed dramatic enhancement of cell adhesion to @entity8 . On the other hand, a  -2,3  -specific @entity3 treatment resulted in moderate enhancement of cell adhesion to @entity8 . We performed chemically artificial modification of cell surface O  -glycans by treatment of benzyl 2  -acetamido  -2  -deoxy  -a  -D  -galactopyranoside  (Bz  -a  -GalNAc) in H  -ALCL. Cell adhesion to @entity8 was enhanced by treatment of Bz  -a  -GalNAc suggesting that inhibition of elongation of O  -glycans may enhance cell adhesion to @entity8 in H  -ALCL cells. On the other hand inhibition of elongation of N  -glycosylation by tunicamycin  (TM) resulted in inhibition of @entity6  (L  -PHA) lectin  -binding activity and inhibited cell adhesion to @entity8 , laminin and fibronectin. @entity3 treatment enhanced cell adhesion to laminin, and knockdown of @entity7 resulted in enhancement of cell adhesion to laminin, but not to fibronectin, collagen type  1  and  4. @entity8 pre  -treatment dramatically enhanced cell adhesion to laminin and @entity3 treatment also enhanced cell adhesion to laminin in combination with @entity8 . Rho inhibitor, C3  -transferase pre  -treatment resulted in inhibition of cell invasion to @entity8 . Phosphatidylinositol  3  -phosphate kinase  (PI3K) inhibitor, wortmannin inhibits the cell invasive capacity to @entity8 . @entity3 treatment induces growth inhibition of @entity4 cells by @entity8 .

title: Sialylation by b  -galactoside a  -2,6  -sialyltransferase and N  -glycans regulate cell adhesion and invasion in XXXX @entity5 .

answer: @entity0


abstract: UNASSIGNED: This is the second of three papers investigating the legislative history concerning infanticide. It compares the efforts of various states to protect the newborn @entity0 between 534 and 1532 CE. When the Roman Empire collapsed in the 5th century, the jurisdiction of infanticide was relegated to the church, which regarded carnal delicts a @entity1 rather than a crime. The punishment - public penance of the mother for 7-15 years - was milder than that which the murder of an adult would incur. The Council of Florence decreed in 1439 that the souls of @entity0 who died without having been baptized descend to hell. This turned infanticide from a penitential @entity1 to the most heinous of all crimes. The states passed laws that abominated infanticide even more than the murder of older @entity0 and punished @entity0 with ever more cruel forms of execution. Towards the @entity0 , however, who usually abandoned the @entity0 they had impregnated, the laws were lenient. Churches and society continued to vilify illegitimate birth, thus enhancing rather than preventing infanticide. The Habsburg-German legislation of 1532 ordained to torture any @entity0 who had concealed pregnancy and birth and claimed the @entity0 was stillborn. Legislation developed similarly in other countries, albeit at a different speed. French (1556) and British (1623) legislation reversed the burden of proof and demanded the death penalty for concealing pregnancy and birth when a dead @entity0 was found.

title: From XXXX to Crime: Laws on Infanticide in the Middle Ages.

answer: @entity1