abstract: OBJECTIVES/HYPOTHESIS: Nasal @entity4 are benign mucosal protrusions into the nasal cavity of multifactorial origin and are characterized by chronic @entity0 . The suggested multifactorial pathological mechanisms comprise several factors including cytokines and @entity7 ( @entity7 ). The study was designed to examine the suggested roles of @entity7 , @entity2 ( @entity2 ), and @entity6 ( @entity6 ) in the pathogenesis of @entity5 . METHODS: Nasal @entity4 (n = 34) and healthy nasal mucosa samples (n = 9) were taken during routine endonasal surgeries. @entity7 (n = 13), @entity2 (n = 22), and @entity6 (n = 27) concentrations were measured with enzyme-linked immunosorbent assay technique in homogenized polyp tissue and in control mucosa. Atopic and nonatopic groups were selected and compared. Histomorphological examination and immunohistochemical analysis to detect @entity2 and @entity6 were performed in five specimens. RESULTS: The level of tissue-bound @entity7 was significantly higher in @entity4 compared with control specimens and in @entity3 compared with nonatopic @entity4 , but between nonatopic @entity4 and control specimens the difference was not significant. However, significant correlation was found between tissue and serum @entity7 in the complete polyp (P =.001) and @entity4 group (P =.05). Tissue @entity2 concentration was significantly higher in @entity4 compared with control specimens, in which it was below the limit (15 pg/mL), and there was no difference between @entity3 and nonatopic @entity4 . In @entity4 there was significant correlation between tissue @entity7 and @entity2 . @entity6 concentration proved to be significantly higher in control mucosa than in @entity4 , with no difference between @entity3 and nonatopic @entity4 . Immunohistochemical analysis revealed numerous @entity2 -positive eosinophil cells and @entity6 positivity in the lamina propria of polyp samples, but none in control specimens. CONCLUSIONS: High tissue @entity6 quantity in healthy nasal mucosa without its active form on the cell surface and its low quantity in @entity4 may reflect its essential role in the inhibitory mechanisms of @entity5 . @entity2 plays a key role in the eosinophil recruitment and activation, and both @entity3 and nonatopic pathways might activate this process. The main sources of @entity2 and @entity6 are the eosinophils and macrophages. Immediate @entity1 , besides other mechanisms, might be related to @entity4 , but the involvement of other, local allergic mechanisms in @entity7 production of nonatopic polyp tissue cannot be excluded.

title: The pathogenesis of @entity5 by @entity7 and @entity2 is completed by XXXX .

answer: @entity6


abstract: UNASSIGNED: Background Currently there are no guidelines regarding optimal screening for @entity4 during pregnancy. Objective This study measures completion rates and the concordance between the TSPOT. @entity3 , a commercially available interferon gamma release assay (IGRA), and the traditional @entity1 ( @entity1 ) in a predominantly urban minority obstetrics practice. Design This is an observational cohort study of 141 pregnant @entity0 enrolled from an obstetrics practice with a large immigrant population. @entity0 with a history of a positive @entity1 result were excluded. Demographic and clinical risk factors for @entity2 were assessed. Enrolled @entity0 underwent a T-SPOT. @entity3 test and placement of @entity1 , and returned in 48-72  h for @entity1 interpretation. We calculated the completion rate and frequency of a positive result for each test, as well as the concordance between the T-SPOT. @entity3 and @entity1 . Results Among the 141 @entity0 enrolled, 75  % were either Latina or African-American, 44  % were born in a country with a high @entity3 prevalence, and 52  % had received the Bacillus Calmette-Guerin vaccine. Seven @entity0 (5  %) had a positive screening test, a total of 3 positive T-SPOT. @entity3 results and 6 positive @entity1 results, and all were from countries with a high @entity3 prevalence. The concordance of the two tests was 96.3  %. The completion rate for the T-SPOT. @entity3 was 98  %, while the completion rate for the @entity1 was 63  %. CONCLUSION: The IGRA test had a markedly higher completion rate in addition to maintaining high concordance with the two-step @entity1 in this population of pregnant @entity0 with a high prevalence of prior @entity3 exposure. Targeted screening of @entity0 from countries with a high prevalence of @entity2 may be warranted during prenatal care.

title: Comparing an Interferon Gamma Release Assay with the Tuberculin Skin Test During Pregnancy: Implications for XXXX Screening During Prenatal Care.

answer: @entity2


abstract: This paper reports, for the first time, on the analysis of @entity2 ( @entity1 ) and @entity3 ( @entity4 ) concentrations in the blood and brains of @entity8 -knockout ( @entity8 -KO) and C57B6/6J ( @entity6 ) @entity0 . Animals were administrated @entity1 (1.0, 2.0 or 4.0  g/kg) or @entity5 ( @entity7 , 82  mg/kg) plus @entity4 (50, 100 or 200  mg/kg) intraperitoneally. During the blood tests, samples from the orbital sinus of the eye were collected. During the brain tests, dialysates were collected every 5  min (equal to a 15    l sample) from the striatum using in vivo brain microdialysis. Samples were collected at 5, 10, 15, 20, 25, 30 and 60  min intervals post- @entity1 and - @entity4 injection, and then analyzed by head-space GC. In the @entity1 groups, high @entity4 levels were found in the blood and brains of @entity8 -KO @entity0 , while only small traces of @entity4 were seen in the blood and brains of @entity6 @entity0 . No significant differences in @entity1 levels were observed between the @entity6 and the @entity8 -KO @entity0 for either the @entity1 dose. @entity1 concentrations in the brain were comparable to the @entity1 concentrations in the blood, but the @entity4 concentrations in the brain were four to five times lower compared to the @entity4 concentrations in the blood. In the @entity4 groups, high @entity4 levels were found in both @entity6 and @entity8 -KO @entity0 . Levels reached a sharp peak at 5  min and then quickly declined for 60  min. Brain @entity4 concentrations were almost equal to the concentrations found in the blood, where the @entity4 concentrations were approximately two times higher in the @entity8 -KO @entity0 than in the @entity6 @entity0 , both in the blood and the brain. Our results suggest that systemic @entity1 and @entity4 administration can cause a greater increase in @entity4 accumulation in the blood and brains of @entity8 -KO @entity0 , where @entity1 concentrations in the @entity8 -KO @entity0 were comparable to the @entity1 concentrations in the @entity6 @entity0 . Furthermore, detection of @entity1 and @entity4 in the blood and brain was found to be dose-dependent in both genotypes.

title: XXXX and @entity3 After Intraperitoneal Administration to @entity8 -Knockout @entity0 -Reflection in Blood and Brain Levels.

answer: @entity2


abstract: This paper reports, for the first time, on the analysis of @entity2 ( @entity1 ) and @entity3 ( @entity4 ) concentrations in the blood and brains of @entity8 -knockout ( @entity8 -KO) and C57B6/6J ( @entity6 ) @entity0 . Animals were administrated @entity1 (1.0, 2.0 or 4.0  g/kg) or @entity5 ( @entity7 , 82  mg/kg) plus @entity4 (50, 100 or 200  mg/kg) intraperitoneally. During the blood tests, samples from the orbital sinus of the eye were collected. During the brain tests, dialysates were collected every 5  min (equal to a 15    l sample) from the striatum using in vivo brain microdialysis. Samples were collected at 5, 10, 15, 20, 25, 30 and 60  min intervals post- @entity1 and - @entity4 injection, and then analyzed by head-space GC. In the @entity1 groups, high @entity4 levels were found in the blood and brains of @entity8 -KO @entity0 , while only small traces of @entity4 were seen in the blood and brains of @entity6 @entity0 . No significant differences in @entity1 levels were observed between the @entity6 and the @entity8 -KO @entity0 for either the @entity1 dose. @entity1 concentrations in the brain were comparable to the @entity1 concentrations in the blood, but the @entity4 concentrations in the brain were four to five times lower compared to the @entity4 concentrations in the blood. In the @entity4 groups, high @entity4 levels were found in both @entity6 and @entity8 -KO @entity0 . Levels reached a sharp peak at 5  min and then quickly declined for 60  min. Brain @entity4 concentrations were almost equal to the concentrations found in the blood, where the @entity4 concentrations were approximately two times higher in the @entity8 -KO @entity0 than in the @entity6 @entity0 , both in the blood and the brain. Our results suggest that systemic @entity1 and @entity4 administration can cause a greater increase in @entity4 accumulation in the blood and brains of @entity8 -KO @entity0 , where @entity1 concentrations in the @entity8 -KO @entity0 were comparable to the @entity1 concentrations in the @entity6 @entity0 . Furthermore, detection of @entity1 and @entity4 in the blood and brain was found to be dose-dependent in both genotypes.

title: @entity2 and XXXX After Intraperitoneal Administration to @entity8 -Knockout @entity0 -Reflection in Blood and Brain Levels.

answer: @entity3


abstract: This paper reports, for the first time, on the analysis of @entity2 ( @entity1 ) and @entity3 ( @entity4 ) concentrations in the blood and brains of @entity8 -knockout ( @entity8 -KO) and C57B6/6J ( @entity6 ) @entity0 . Animals were administrated @entity1 (1.0, 2.0 or 4.0  g/kg) or @entity5 ( @entity7 , 82  mg/kg) plus @entity4 (50, 100 or 200  mg/kg) intraperitoneally. During the blood tests, samples from the orbital sinus of the eye were collected. During the brain tests, dialysates were collected every 5  min (equal to a 15    l sample) from the striatum using in vivo brain microdialysis. Samples were collected at 5, 10, 15, 20, 25, 30 and 60  min intervals post- @entity1 and - @entity4 injection, and then analyzed by head-space GC. In the @entity1 groups, high @entity4 levels were found in the blood and brains of @entity8 -KO @entity0 , while only small traces of @entity4 were seen in the blood and brains of @entity6 @entity0 . No significant differences in @entity1 levels were observed between the @entity6 and the @entity8 -KO @entity0 for either the @entity1 dose. @entity1 concentrations in the brain were comparable to the @entity1 concentrations in the blood, but the @entity4 concentrations in the brain were four to five times lower compared to the @entity4 concentrations in the blood. In the @entity4 groups, high @entity4 levels were found in both @entity6 and @entity8 -KO @entity0 . Levels reached a sharp peak at 5  min and then quickly declined for 60  min. Brain @entity4 concentrations were almost equal to the concentrations found in the blood, where the @entity4 concentrations were approximately two times higher in the @entity8 -KO @entity0 than in the @entity6 @entity0 , both in the blood and the brain. Our results suggest that systemic @entity1 and @entity4 administration can cause a greater increase in @entity4 accumulation in the blood and brains of @entity8 -KO @entity0 , where @entity1 concentrations in the @entity8 -KO @entity0 were comparable to the @entity1 concentrations in the @entity6 @entity0 . Furthermore, detection of @entity1 and @entity4 in the blood and brain was found to be dose-dependent in both genotypes.

title: @entity2 and @entity3 After Intraperitoneal Administration to XXXX -Knockout @entity0 -Reflection in Blood and Brain Levels.

answer: @entity8


abstract: This paper reports, for the first time, on the analysis of @entity2 ( @entity1 ) and @entity3 ( @entity4 ) concentrations in the blood and brains of @entity8 -knockout ( @entity8 -KO) and C57B6/6J ( @entity6 ) @entity0 . Animals were administrated @entity1 (1.0, 2.0 or 4.0  g/kg) or @entity5 ( @entity7 , 82  mg/kg) plus @entity4 (50, 100 or 200  mg/kg) intraperitoneally. During the blood tests, samples from the orbital sinus of the eye were collected. During the brain tests, dialysates were collected every 5  min (equal to a 15    l sample) from the striatum using in vivo brain microdialysis. Samples were collected at 5, 10, 15, 20, 25, 30 and 60  min intervals post- @entity1 and - @entity4 injection, and then analyzed by head-space GC. In the @entity1 groups, high @entity4 levels were found in the blood and brains of @entity8 -KO @entity0 , while only small traces of @entity4 were seen in the blood and brains of @entity6 @entity0 . No significant differences in @entity1 levels were observed between the @entity6 and the @entity8 -KO @entity0 for either the @entity1 dose. @entity1 concentrations in the brain were comparable to the @entity1 concentrations in the blood, but the @entity4 concentrations in the brain were four to five times lower compared to the @entity4 concentrations in the blood. In the @entity4 groups, high @entity4 levels were found in both @entity6 and @entity8 -KO @entity0 . Levels reached a sharp peak at 5  min and then quickly declined for 60  min. Brain @entity4 concentrations were almost equal to the concentrations found in the blood, where the @entity4 concentrations were approximately two times higher in the @entity8 -KO @entity0 than in the @entity6 @entity0 , both in the blood and the brain. Our results suggest that systemic @entity1 and @entity4 administration can cause a greater increase in @entity4 accumulation in the blood and brains of @entity8 -KO @entity0 , where @entity1 concentrations in the @entity8 -KO @entity0 were comparable to the @entity1 concentrations in the @entity6 @entity0 . Furthermore, detection of @entity1 and @entity4 in the blood and brain was found to be dose-dependent in both genotypes.

title: @entity2 and @entity3 After Intraperitoneal Administration to @entity8 -Knockout XXXX -Reflection in Blood and Brain Levels.

answer: @entity0


abstract: The prognosis of @entity0 with @entity4 remains poor. In @entity0 with distant metastases only low response rates between 10% and 15% have been achieved by the most effective cytostatics in single-agent therapy leading to a mean 5-year survival rate of less than 5%. More aggressive treatment regimens using multidrug chemotherapy yielded response rates of up to 40% but failed to show a significant benefit in overall survival compared to single-agent therapy. However, complete remissions of @entity1 after multidrug cytostatic regimens have been reported in some cases of @entity4 @entity0 . To evaluate an in vitro test system providing information on the drug sensitivity profile of @entity4 cells, we examined @entity2 tissue specimens from 31 @entity4 @entity0 with an @entity5 -based chemosensitivity assay ( @entity5 - @entity8 ) testing eight anticancer drugs alone or in different combinations. Chemosensitivity was assessed using a @entity9 -luciferase- based luminescence assay providing individual chemosensitivity indices for each test drug. We found a heterogeneous chemosensitivity in the @entity4 tissue samples tested. The highest sensitivity was detected for the combination of @entity10 and @entity3 , with 76% of the tissue samples revealing high sensitivity and 10% resistance, followed by the combination of @entity7 and @entity11 (66%/0%), @entity3 and @entity6 (55%/21%),and @entity7 and @entity6 (46%/8%). Our data indicate that the @entity5 - @entity8 can be used to select @entity0 who might benefit from an individually adapted cytostatic therapy. On the basis of these results a multicenter trial has recently been initiated to evaluate the feasibility and predictive value of an @entity5 - @entity8 directed chemotherapy in @entity4 @entity0 .

title: Chemosensitivity testing in XXXX .

answer: @entity4


abstract: BACKGROUND: The @entity1 olfactory system exhibits very precise and stereotyped wiring that is specified predominantly by genetic programming. Dendrites of olfactory projection neurons (PNs) pattern the developing antennal lobe before olfactory receptor neuron axon arrival, indicating an intrinsic wiring mechanism for @entity3 dendrites. These wiring decisions are likely determined through a transcriptional program. RESULTS: We find that loss of @entity6 associated protein 55 kD (Bap55) results in a highly specific @entity3 mistargeting phenotype. In Bap55 mutants, PNs that normally target to the @entity4 glomerulus mistarget to the @entity8 l glomerulus with 100% penetrance. Loss of Bap55 also causes derepression of a @entity5 whose expression is normally restricted to a small subset of PNs. Bap55 is a member of both the @entity6 ( @entity6 ) and the @entity7 ( @entity7 ) @entity2 -dependent chromatin remodeling complexes. The Bap55 mutant phenotype is partially recapitulated by Domino and Enhancer of Polycomb mutants, members of the @entity7 complex. However, distinct phenotypes are seen in @entity6 and Snf5-related 1 mutants, members of the @entity6 complex. The Bap55 mutant phenotype can be rescued by postmitotic expression of Bap55, or its @entity0 homologs @entity9 and @entity10 . CONCLUSIONS: Our results suggest that Bap55 functions through the @entity7 chromatin remodeling complex to regulate dendrite wiring specificity in PNs. The specificity of the mutant phenotypes suggests a position for the @entity7 complex at the top of a regulatory hierarchy that orchestrates dendrite targeting decisions.

title: The chromatin remodeling factor Bap55 functions through the XXXX complex to regulate olfactory projection neuron dendrite targeting.

answer: @entity7


abstract: BACKGROUND: @entity3 is the single most common soft tissue @entity2 in the retroperitoneum. MATERIALS AND METHODS: A retrospective review of @entity0 with primary @entity4 treated between June 1990 and June 2005 were conducted to evaluate the clinical results of resection for @entity4 ( @entity4 ) and the prognostic factors for disease recurrence and @entity0 survival in an Asian population. RESULTS: Twenty-one @entity0 operated on for curative intent (12 Males, 9 Females; mean age: 52.4 years) were evaluated. Of these, 13 presented with @entity1 that were well differentiated (61.9%), 4 (19.0%) with myxoid/round cell, 3 (14.3%) with dedifferentiated and 1(4.8%) with pleomorphic morphology. The median @entity1 burden was 36 cm (9-83). Median follow-up time was 62 months. There was no peri-operative mortality and morbidity occurred in 6(28.6%) @entity0 . Surgical margins were involved in 10(47.6%) @entity0 . Resection of contiguous organs was required in 15(71.4%) to achieve gross surgical margins. Eleven out of the 21(52%) of the @entity0 had recurrence of the @entity1 . Median disease-free survival was 19 months and the overall 3- and 5-year survival rate was 87% and 49% respectively. CONCLUSION: An aggressive surgical approach in both primary and recurrent @entity4 in our institution is associated with 3- and 5-year survival rate of 87% and 49% respectively. Contiguous organ resection is often required to achieve local control.

title: XXXX : the experience of a tertiary Asian center.

answer: @entity4


abstract: @entity7 is a ligand and chemotactic factor for @entity1 + T cells. @entity7 inhibits the CD3 mediated lymphocyte activation and proliferation. The effects of @entity7 on the target cells are dependent on the cell type, the presence of co-activators etc. To understand the regulation function and mechanism of @entity7 on target cells, we used a 130 a.a. recombinant @entity7 to study its effects on the growth of @entity3 cells in vitro. We found that the @entity8 stimulated the proliferation of Jurkat cells at low dose (10(-9)M), but inhibited the growth of the cells at higher concentration (10(-5)M). Results showed that 10(-5) M of @entity8 treatment induced an enhanced apoptosis in Jurkat cells. The treatment blocked the expression of @entity0 , but up-regulated the @entity2 and @entity4 expression in the cells. Pre-treatment of @entity5 inhibitor or @entity6 inhibitor markedly increased or decreased the @entity8 induced growth-inhibiting effects on Jurkat cells, respectively. The results suggested that the @entity8 might be a regulator for the growth or apoptosis of Jurkat cells at a dose-dependent manner. The growth-inhibiting effects of @entity8 might be Fas/ @entity0 independent, but, associated with the activation of @entity5 , up-regulated expression of @entity2 and @entity4 , and the participation of the ERK signal pathway in Jurkat cells.

title: The associated regulators and signal pathway in XXXX / @entity1 mediated growth regulation in Jurkat cells.

answer: @entity8


abstract: @entity7 is a ligand and chemotactic factor for @entity1 + T cells. @entity7 inhibits the CD3 mediated lymphocyte activation and proliferation. The effects of @entity7 on the target cells are dependent on the cell type, the presence of co-activators etc. To understand the regulation function and mechanism of @entity7 on target cells, we used a 130 a.a. recombinant @entity7 to study its effects on the growth of @entity3 cells in vitro. We found that the @entity8 stimulated the proliferation of Jurkat cells at low dose (10(-9)M), but inhibited the growth of the cells at higher concentration (10(-5)M). Results showed that 10(-5) M of @entity8 treatment induced an enhanced apoptosis in Jurkat cells. The treatment blocked the expression of @entity0 , but up-regulated the @entity2 and @entity4 expression in the cells. Pre-treatment of @entity5 inhibitor or @entity6 inhibitor markedly increased or decreased the @entity8 induced growth-inhibiting effects on Jurkat cells, respectively. The results suggested that the @entity8 might be a regulator for the growth or apoptosis of Jurkat cells at a dose-dependent manner. The growth-inhibiting effects of @entity8 might be Fas/ @entity0 independent, but, associated with the activation of @entity5 , up-regulated expression of @entity2 and @entity4 , and the participation of the ERK signal pathway in Jurkat cells.

title: The associated regulators and signal pathway in @entity8 / XXXX mediated growth regulation in Jurkat cells.

answer: @entity1


abstract: OBJECTIVE: Homeless @entity0 with @entity1 and other drug (AOD) disorders face multiple problems that go beyond their AOD use. As a consequence, they commonly access services in multiple sectors in addition to the AOD treatment system. This study examined the predictors of contact with agencies in the health, mental health, social welfare and criminal justice sectors by AOD status among a probability sample of homeless adults in Houston, Texas. METHOD: Cross-sectional data were collected from a multistage random sample of 797 homeless adults (579 @entity0 ), age 18 or older, who were living in shelters and on the streets of Houston in 1996. Structured face-to-face interviews provided screening diagnoses for @entity2 , self-report data on AOD treatment use and candidate predictors of treatment use. Service use was tracked retrospectively through administrative data obtained from 10 federal, state, county and municipal agencies that provide finding for physical and mental health services and AOD treatment, as well as emergency income; we also tracked criminal justice contacts. Logistic regression analyses were stratified by AOD status. RESULTS: Adjusting for eligibility factors, key aspects of need were significant predictors of any utilization among those without an AOD problem, but not for those with an AOD problem. For those with @entity2 , contact with one sector was not predictive of contact with other sectors. CONCLUSIONS: Our findings indicate that @entity2 hinder utilization of public sector services by homeless @entity0 . These disorders may be masking need or otherwise acting as a barrier to accessing treatment and support.

title: Predictors of contact with public service sectors among homeless adults with and without XXXX and other drug disorders.

answer: @entity1


abstract: BACKGROUND: Functional brain imaging offers a way to investigate how general anaesthetics impair consciousness. However, functional imaging changes may result from drug effects unrelated to hypnosis. Establishing a causal link with @entity1 is thus difficult. METHODS: To identify changes of neuronal activity functionally linked to the level of consciousness, @entity3 was used to restore consciousness without changing the anaesthetic concentration in 11 subjects anaesthetized with @entity2 . Eight subjects (responders) regained consciousness after @entity3 and three did not (non-responders). Positron emission tomography was used to measure regional cerebral blood flow (rCBF); during baseline (awake), after anaesthesia-induced @entity1 , after @entity3 administration, and recovery. In addition to subtraction analyses, we used conjunction analysis in the responders to identify changes common to the baseline-anaesthesia and @entity3 -anaesthesia contrasts. RESULTS: Complete data were available for seven subjects (four responders and three non-responders). The analyses revealed that @entity1 was associated with rCBF decreases in the thalamus and precuneus. Restoration of consciousness by @entity3 was associated with rCBF increases in these same structures, with the strongest effect in the thalamus. CONCLUSIONS: The results provide strong evidence that reductions in rCBF in the thalamus and precuneus are functionally related to @entity2 -induced @entity1 independently of any non-specific effects of @entity2 . These observations confirm that the thalamus and precuneus are key elements to understand how general anaesthetics cause @entity1 and how @entity0 wake up from anaesthesia. Furthermore, they are consistent with the notion that anaesthetic-induced @entity1 is associated with reduced cholinergic activation.

title: Critical involvement of the thalamus and precuneus during restoration of consciousness with XXXX in @entity0 during @entity2 anaesthesia: a positron emission tomography study.

answer: @entity3


abstract: BACKGROUND: Functional brain imaging offers a way to investigate how general anaesthetics impair consciousness. However, functional imaging changes may result from drug effects unrelated to hypnosis. Establishing a causal link with @entity1 is thus difficult. METHODS: To identify changes of neuronal activity functionally linked to the level of consciousness, @entity3 was used to restore consciousness without changing the anaesthetic concentration in 11 subjects anaesthetized with @entity2 . Eight subjects (responders) regained consciousness after @entity3 and three did not (non-responders). Positron emission tomography was used to measure regional cerebral blood flow (rCBF); during baseline (awake), after anaesthesia-induced @entity1 , after @entity3 administration, and recovery. In addition to subtraction analyses, we used conjunction analysis in the responders to identify changes common to the baseline-anaesthesia and @entity3 -anaesthesia contrasts. RESULTS: Complete data were available for seven subjects (four responders and three non-responders). The analyses revealed that @entity1 was associated with rCBF decreases in the thalamus and precuneus. Restoration of consciousness by @entity3 was associated with rCBF increases in these same structures, with the strongest effect in the thalamus. CONCLUSIONS: The results provide strong evidence that reductions in rCBF in the thalamus and precuneus are functionally related to @entity2 -induced @entity1 independently of any non-specific effects of @entity2 . These observations confirm that the thalamus and precuneus are key elements to understand how general anaesthetics cause @entity1 and how @entity0 wake up from anaesthesia. Furthermore, they are consistent with the notion that anaesthetic-induced @entity1 is associated with reduced cholinergic activation.

title: Critical involvement of the thalamus and precuneus during restoration of consciousness with @entity3 in @entity0 during XXXX anaesthesia: a positron emission tomography study.

answer: @entity2


abstract: BACKGROUND: Functional brain imaging offers a way to investigate how general anaesthetics impair consciousness. However, functional imaging changes may result from drug effects unrelated to hypnosis. Establishing a causal link with @entity1 is thus difficult. METHODS: To identify changes of neuronal activity functionally linked to the level of consciousness, @entity3 was used to restore consciousness without changing the anaesthetic concentration in 11 subjects anaesthetized with @entity2 . Eight subjects (responders) regained consciousness after @entity3 and three did not (non-responders). Positron emission tomography was used to measure regional cerebral blood flow (rCBF); during baseline (awake), after anaesthesia-induced @entity1 , after @entity3 administration, and recovery. In addition to subtraction analyses, we used conjunction analysis in the responders to identify changes common to the baseline-anaesthesia and @entity3 -anaesthesia contrasts. RESULTS: Complete data were available for seven subjects (four responders and three non-responders). The analyses revealed that @entity1 was associated with rCBF decreases in the thalamus and precuneus. Restoration of consciousness by @entity3 was associated with rCBF increases in these same structures, with the strongest effect in the thalamus. CONCLUSIONS: The results provide strong evidence that reductions in rCBF in the thalamus and precuneus are functionally related to @entity2 -induced @entity1 independently of any non-specific effects of @entity2 . These observations confirm that the thalamus and precuneus are key elements to understand how general anaesthetics cause @entity1 and how @entity0 wake up from anaesthesia. Furthermore, they are consistent with the notion that anaesthetic-induced @entity1 is associated with reduced cholinergic activation.

title: Critical involvement of the thalamus and precuneus during restoration of consciousness with @entity3 in XXXX during @entity2 anaesthesia: a positron emission tomography study.

answer: @entity0


abstract: OBJECTIVE: Although several lines of evidence implicate gray @entity1 in the prefrontal cortex and anterior cingulate cortex in @entity0 with @entity2 , findings have been largely inconsistent across studies. Differences in @entity0 ' medication status or mood state or the application of traditional volumetric methods that are insensitive to subtle neuroanatomical differences may have contributed to variations in findings. The authors used MRI in conjunction with cortical pattern matching methods to assess @entity5 in euthymic bipolar @entity0 who were not receiving @entity4 treatment. METHOD: Thirty-four @entity4 -free euthymic @entity0 with @entity2 and 31 healthy comparison subjects underwent MRI scanning. Data were processed to measure cortical gray matter thickness. Thickness maps were spatially normalized using cortical pattern matching and were analyzed to assess illness effects and associations with clinical variables. RESULTS: Relative to healthy comparison subjects, euthymic bipolar @entity0 had significantly thinner gray matter in the left and right prefrontal cortex (Brodmann's areas 11, 10, 8, and 44) and the left anterior cingulate cortex (Brodmann's areas 24/32). Thinning in these regions was more pronounced in @entity0 with a history of @entity3 . No areas of thicker cortex were detected in bipolar @entity0 relative to healthy comparison subjects. CONCLUSIONS: Using a technique that is highly sensitive to subtle neuroanatomical differences, significant regional cortical thinning was found in @entity4 -free euthymic @entity0 with @entity2 .

title: Investigation of @entity5 in @entity4 -free adults with XXXX using cortical pattern matching.

answer: @entity2


abstract: OBJECTIVE: Although several lines of evidence implicate gray @entity1 in the prefrontal cortex and anterior cingulate cortex in @entity0 with @entity2 , findings have been largely inconsistent across studies. Differences in @entity0 ' medication status or mood state or the application of traditional volumetric methods that are insensitive to subtle neuroanatomical differences may have contributed to variations in findings. The authors used MRI in conjunction with cortical pattern matching methods to assess @entity5 in euthymic bipolar @entity0 who were not receiving @entity4 treatment. METHOD: Thirty-four @entity4 -free euthymic @entity0 with @entity2 and 31 healthy comparison subjects underwent MRI scanning. Data were processed to measure cortical gray matter thickness. Thickness maps were spatially normalized using cortical pattern matching and were analyzed to assess illness effects and associations with clinical variables. RESULTS: Relative to healthy comparison subjects, euthymic bipolar @entity0 had significantly thinner gray matter in the left and right prefrontal cortex (Brodmann's areas 11, 10, 8, and 44) and the left anterior cingulate cortex (Brodmann's areas 24/32). Thinning in these regions was more pronounced in @entity0 with a history of @entity3 . No areas of thicker cortex were detected in bipolar @entity0 relative to healthy comparison subjects. CONCLUSIONS: Using a technique that is highly sensitive to subtle neuroanatomical differences, significant regional cortical thinning was found in @entity4 -free euthymic @entity0 with @entity2 .

title: Investigation of @entity5 in XXXX -free adults with @entity2 using cortical pattern matching.

answer: @entity4


abstract: OBJECTIVE: Although several lines of evidence implicate gray @entity1 in the prefrontal cortex and anterior cingulate cortex in @entity0 with @entity2 , findings have been largely inconsistent across studies. Differences in @entity0 ' medication status or mood state or the application of traditional volumetric methods that are insensitive to subtle neuroanatomical differences may have contributed to variations in findings. The authors used MRI in conjunction with cortical pattern matching methods to assess @entity5 in euthymic bipolar @entity0 who were not receiving @entity4 treatment. METHOD: Thirty-four @entity4 -free euthymic @entity0 with @entity2 and 31 healthy comparison subjects underwent MRI scanning. Data were processed to measure cortical gray matter thickness. Thickness maps were spatially normalized using cortical pattern matching and were analyzed to assess illness effects and associations with clinical variables. RESULTS: Relative to healthy comparison subjects, euthymic bipolar @entity0 had significantly thinner gray matter in the left and right prefrontal cortex (Brodmann's areas 11, 10, 8, and 44) and the left anterior cingulate cortex (Brodmann's areas 24/32). Thinning in these regions was more pronounced in @entity0 with a history of @entity3 . No areas of thicker cortex were detected in bipolar @entity0 relative to healthy comparison subjects. CONCLUSIONS: Using a technique that is highly sensitive to subtle neuroanatomical differences, significant regional cortical thinning was found in @entity4 -free euthymic @entity0 with @entity2 .

title: Investigation of XXXX in @entity4 -free adults with @entity2 using cortical pattern matching.

answer: @entity5


abstract: With an enzyme-linked immunosorbent assay antigen, specific @entity3 ( @entity3 ) were demonstrated in experimental and @entity0 @entity2 . In experimentally infected @entity1 , @entity3 became demonstrable as soon as antibodies appeared after fatal infection. When a nonvirulent strain of Toxoplasma was used @entity3 remained detectable for several weeks. This period was characterized by clinically healthy animals with increasing antibody titers and by cysts growing in the brains of the animals, indicating a subacute stage of the toxoplasma infection. In the @entity0 sera, a surprisingly high percentage of @entity3 was demonstrated. Both immunoglobulin G (IgG) and IgM were found in the @entity3 ; however, IgG was seen in the majority. If the @entity0 were grouped according to other serological results, such as a combination with IgM antibodies, circulating antigens, or both, or a positive complement fixation test, increasingly more @entity3 were observed. When sera were selected from @entity0 with clinical symptoms generally associated with @entity2 , more @entity3 were also again demonstrated. On the contrary, in healthy individuals (blood donors), @entity3 were also regularly observed, suggesting that exacerbations of latent infections or reinfections may regularly occur without leading to clinical signs. In conclusion, we propose that the interpretation of a positive @entity3 test requires great care but may provide useful information about the activity of a toxoplasma infection.

title: Demonstration of Toxoplasma antigen containing complexes in active XXXX .

answer: @entity2


abstract: INTRODUCTION: Although palliative care is a rewarding specialty, it presents emotive personal challenges for the health professionals working within it. Terminal @entity1 is arguably the most feared and distressing event in the palliative care setting, both for the @entity0 and for the health professionals looking after them. The aim of this study was to explore and reflect on the coping and support mechanisms that have helped nurses to manage these events. METHOD: Purposive sampling was used to recruit nurses from palliative care and oncology who had personal experience of managing terminal @entity1 . Semi-structured interviews were used to collect qualitative data that were then analysed using interpretative phenomenological analysis. Saturation of data was reached after 11 @entity0 had been interviewed. RESULTS: The @entity0 had a combined experience of managing 37 @entity0 with a terminal @entity1 . The key themes that emerged were the role of the 'autopilot', having a plan, education and training, the value of debriefing and peer support, and the importance of supporting the whole team. Education and training specifically about terminal @entity1 and structured debriefing after such events were both identified by the @entity0 as currently unmet needs. CONCLUSION: Professionals working in areas in which @entity0 are at particular risk of terminal @entity1 require adequate training and education prior to these events and a structure for formal debriefing and peer support afterwards.

title: Nurses' views of the coping and support mechanisms experienced in managing terminal XXXX .

answer: @entity1


abstract: BACKGROUND: Characteristically, @entity5 affects younger @entity0 who typically refer to the orthopedic surgeon for the first time in the third to fifth decades of life, in the late stages of the disease. Femoral metal-on-metal hip resurfacing is as an alternative to conventional total hip arthroplasty in treating @entity2 . Since there are already many reports regarding the successful outcome of resurfacing in advanced @entity3 , the purpose of this study was to analyze the clinical outcomes of this procedure in @entity0 with @entity5 of the femoral head and to compare them with a matched group of @entity0 with @entity3 . MATERIAL/METHODS: This retrospective cohort study evaluated a consecutive series of 52 @entity0 with end-stage @entity5 (28 @entity0 ) and @entity3 (24 @entity0 ) of the femoral head, managed by metal-on-metal hip resurfacing in a referral orthopedic center from Feb 2002 to May 2007. @entity1 , function and deformity were evaluated with the use of the Harris hip score after the operation. @entity0 were clinically followed for a mean of 41 months. RESULTS: The @entity0 in the @entity3 group had a significantly higher mean age than those in the @entity5 group (47.88    12.6 vs 30.86    7.5, p=0.003). The clinical outcomes were similar for both groups. There was no significant difference in mean Harris hip score (p=0.347) and @entity4 (p=0.346) between @entity5 and @entity3 groups after surgery. CONCLUSIONS: On the basis of these initial findings, we recommend MOM resurfacing as a viable treatment option for @entity0 with advanced stages of @entity5 .

title: Total hip arthroplasty in advanced XXXX : the short-term results by metal-on-metal hip resurfacing.

answer: @entity5


abstract: OBJECTIVE: Prior research on @entity0 with substance use disorders has shown that lifetime physical or @entity1 is associated with more impaired functioning at treatment intake. The present study sought to determine whether physical or @entity1 also predicted treatment response (posttreatment outcomes) of individuals with substance use disorders. METHOD: Male (n = 19,989) and female (n = 622) veterans with substance use disorders were assessed with the Addiction Severity Index (ASI) early in treatment and reassessed an average of 12 months later. Treatment outcomes were compared for @entity0 who did and did not report prior physical or @entity1 in the initial ASI interview. RESULTS: Lifetime physical or @entity1 predicted worse outcomes in six of seven domains of functioning, after controlling for baseline functioning, psychiatric diagnoses and demographic variables. Although @entity0 were more likely than @entity0 to report being abused, the effect of abuse on treatment outcomes was similar for both genders. Psychiatric problems at baseline mediated the effect of abuse history on outcomes. Abuse history moderated the effect of treatment intensity (contacts per month) on outcomes: More frequent treatment contacts were more beneficial for abused @entity0 than for nonabused @entity0 . CONCLUSIONS: Individuals with substance use disorders who have a history of physical or @entity1 may have higher risk for problematic treatment outcomes as a result of greater psychiatric problems, deficits in social support and possible difficulties in establishing treatment alliance. Clinicians may consider increasing the duration and intensity of treatment to temper the negative effects of abuse on later functioning.

title: Physical and XXXX history and addiction treatment outcomes.

answer: @entity1


abstract: The aim of the investigation is the identification of neuronal types in the visual cortex of the @entity2 ( @entity2 ) in Nissl preparations. In two rapid Golgi series (modified by Fair  n et al. 1977) and nine Golgi-Kopsch series eleven neuronal types could be classified: 1. Neurons with long axonal main stems: Pyramidal cells (layers II-VI), pyramid-like cells (layers I, VI), spiny stellate cells (layer IV). 2. Neurons with locally distributed axons: large and small aspiny cells (layers II-VI), neuroglioform cells (layers I-VI), large sparsely spiny cells with ascending axons (Martinotti cells) (layers III-VI), small sparsely spiny cells with variable axons (layer IV), @entity0 (layers II-VI), chandelier cells (layers II, III), double bouquet cells (layers II, III), and 3. a horizontal cell in layer I without an impregnated axon. To identify Nissl stained somata, Golgi impregnated neurons were deimpregnated. Now cytoplasmic and nuclear features can be compared. In order to get a survey about the variability of the somal features, we have deimpregnated 245 neurons on the whole using either @entity4 (Fair  n et al. 1977) combined with the rapid Golgi method, modified by Fair  n et al. (1977), or a diluted solution of @entity3 (Braak and Braak 1982) combined with the Golgi-Kopsch method, nonembedded, in @entity1 stored material and in celloidin embedded sections, resp. After deimpregnation several neuronal classes could be distinguished considering at first the width of the cytoplasm and the localization of the nucleus. There are Nissl stained somata with corresponding features: 1. Pyramidal cells, pyramid-like cells, and spiny stellate cells of the layer IV with relatively broad cytoplasm and bright, centrally localized nuclei. 2. Large aspiny cells which vary in somal sizes and shapes with very broad cytoplasm and bright, centrally or excentrally localized nuclei. 3. Small aspiny cells, some of the neuroglioform cells, and small sparsely spiny cells of layer IV have more or less broad cytoplasm but in the most cases excentrally localized nuclei. 4. The remaining neuroglioform cells, @entity0 , and the horizontal cell of layer I are particularly poor in cytoplasm. The somata of these neuronal types are small, those of the @entity0 are vertically orientated. 5. Like the @entity0 large sparsely spiny cells with ascending axons Martinotti cells), chandelier cells, and double bouquet cells are also polarized neurons, but larger and not always vertically oriented.(ABSTRACT TRUNCATED AT 400 WORDS)

title: [Classification of neurons in the visual cortex of the XXXX ( @entity2 ). A combined Golgi-Nissl study using deimpregnation technics].

answer: @entity2


abstract: The aim of the investigation is the identification of neuronal types in the visual cortex of the @entity2 ( @entity2 ) in Nissl preparations. In two rapid Golgi series (modified by Fair  n et al. 1977) and nine Golgi-Kopsch series eleven neuronal types could be classified: 1. Neurons with long axonal main stems: Pyramidal cells (layers II-VI), pyramid-like cells (layers I, VI), spiny stellate cells (layer IV). 2. Neurons with locally distributed axons: large and small aspiny cells (layers II-VI), neuroglioform cells (layers I-VI), large sparsely spiny cells with ascending axons (Martinotti cells) (layers III-VI), small sparsely spiny cells with variable axons (layer IV), @entity0 (layers II-VI), chandelier cells (layers II, III), double bouquet cells (layers II, III), and 3. a horizontal cell in layer I without an impregnated axon. To identify Nissl stained somata, Golgi impregnated neurons were deimpregnated. Now cytoplasmic and nuclear features can be compared. In order to get a survey about the variability of the somal features, we have deimpregnated 245 neurons on the whole using either @entity4 (Fair  n et al. 1977) combined with the rapid Golgi method, modified by Fair  n et al. (1977), or a diluted solution of @entity3 (Braak and Braak 1982) combined with the Golgi-Kopsch method, nonembedded, in @entity1 stored material and in celloidin embedded sections, resp. After deimpregnation several neuronal classes could be distinguished considering at first the width of the cytoplasm and the localization of the nucleus. There are Nissl stained somata with corresponding features: 1. Pyramidal cells, pyramid-like cells, and spiny stellate cells of the layer IV with relatively broad cytoplasm and bright, centrally localized nuclei. 2. Large aspiny cells which vary in somal sizes and shapes with very broad cytoplasm and bright, centrally or excentrally localized nuclei. 3. Small aspiny cells, some of the neuroglioform cells, and small sparsely spiny cells of layer IV have more or less broad cytoplasm but in the most cases excentrally localized nuclei. 4. The remaining neuroglioform cells, @entity0 , and the horizontal cell of layer I are particularly poor in cytoplasm. The somata of these neuronal types are small, those of the @entity0 are vertically orientated. 5. Like the @entity0 large sparsely spiny cells with ascending axons Martinotti cells), chandelier cells, and double bouquet cells are also polarized neurons, but larger and not always vertically oriented.(ABSTRACT TRUNCATED AT 400 WORDS)

title: [Classification of neurons in the visual cortex of the @entity2 ( XXXX ). A combined Golgi-Nissl study using deimpregnation technics].

answer: @entity2


abstract: BACKGROUND: This study was to evaluate the subclinical @entity3 with 2-dimensional speckle-tracking echocardiography in subjects with @entity0 ( @entity0 ) with normal left ventricular ejection fraction and without any confounding disease that can cause @entity1 . METHODS: Nineteen healthy individuals and 60 subjects with @entity0 were included in this study. According to the severity of disease, @entity0 subjects were examined in 3 groups: mild, moderate, and severe @entity0 . LV apical views (for longitudinal strain) and short-axis views (for circumferential strain) were acquired for evaluation. Three-layer longitudinal strain values and circumferential strain values were determined for each view, and averages of these were used in comparison with other groups. RESULTS: Three-layer longitudinal strain values of the subjects with @entity0 were lower than those of the healthy individuals, and these values were decreased along with the @entity0 severity. The difference was significant between severe @entity0 and all other groups. Three-layer circumferential strain values of the @entity0 subjects were lower than those of the healthy individuals, and the difference was significant between the control group and all other groups. The @entity2 hypopnea index was found to be correlated with the 3-layer longitudinal strain (r = -0.74, P < .001; r = -0.72, P < .001; r = -0.69, P = <.001). CONCLUSIONS: Three-layer longitudinal and circumferential LV systolic functions in @entity0 subjects with normal left ventricular ejection fraction are deteriorated in the subclinical stage. Two-dimensional speckle-tracking echocardiography can be used as an effective method in the determination of subclinical @entity1 in subjects with @entity0 .

title: A Novel Method for Sensitive Determination of Subclinical Left-Ventricular Systolic Dysfunction in Subjects With Obstructive Sleep XXXX .

answer: @entity2


abstract: OBJECTIVE: To investigate the characteristics of @entity1 comorbidity in @entity4 @entity0 . METHOD: The psychological investigation and evaluation were done in 100 @entity4 @entity0 by using self-reporting inventory 90 (SCL-90). All the results were compared with healthy Chinese population, including factors of gender, age, course of disease and education level, using rank-sum test analysis, SPSS 19.0. RESULT: Mild and moderate levels of @entity3 were respectively noted in 65% and 14%, with high score of somatization (P < 0.05), obsession (P < 0.05), interpersonal sensitivity (P < 0.05), @entity2 (P < 0.05) and other (sleep, diet, P < 0.05) compared with control group. The factor scores of obsession (P < 0.05), @entity2 (P < 0.05) in male group were higher than female group. The factor scores of somatization (P < 0.05) and obsession (P < 0.05) in junior group were higher than senior group. The factor scores of somatization (P < 0.05), interpersonal sensitivity (P < 0.05) and @entity2 (P < 0.05) in long course group were higher than short course group. The factor score of interpersonal sensitivity (P < 0.05) in low educated group was higher than highly educated group. CONCLUSION: @entity1 are prevalent in @entity4 @entity0 , especially upon the factors of somatization, obsession, interpersonal sensitivity, @entity2 and other (sleep, diet). Male, junior, long course @entity0 and low educated are in high risk group.

title: [ @entity1 in XXXX @entity0 and its associated factor analysis].

answer: @entity4


abstract: OBJECTIVE: To investigate the characteristics of @entity1 comorbidity in @entity4 @entity0 . METHOD: The psychological investigation and evaluation were done in 100 @entity4 @entity0 by using self-reporting inventory 90 (SCL-90). All the results were compared with healthy Chinese population, including factors of gender, age, course of disease and education level, using rank-sum test analysis, SPSS 19.0. RESULT: Mild and moderate levels of @entity3 were respectively noted in 65% and 14%, with high score of somatization (P < 0.05), obsession (P < 0.05), interpersonal sensitivity (P < 0.05), @entity2 (P < 0.05) and other (sleep, diet, P < 0.05) compared with control group. The factor scores of obsession (P < 0.05), @entity2 (P < 0.05) in male group were higher than female group. The factor scores of somatization (P < 0.05) and obsession (P < 0.05) in junior group were higher than senior group. The factor scores of somatization (P < 0.05), interpersonal sensitivity (P < 0.05) and @entity2 (P < 0.05) in long course group were higher than short course group. The factor score of interpersonal sensitivity (P < 0.05) in low educated group was higher than highly educated group. CONCLUSION: @entity1 are prevalent in @entity4 @entity0 , especially upon the factors of somatization, obsession, interpersonal sensitivity, @entity2 and other (sleep, diet). Male, junior, long course @entity0 and low educated are in high risk group.

title: [ XXXX in @entity4 @entity0 and its associated factor analysis].

answer: @entity1


abstract: OBJECTIVE: To investigate the characteristics of @entity1 comorbidity in @entity4 @entity0 . METHOD: The psychological investigation and evaluation were done in 100 @entity4 @entity0 by using self-reporting inventory 90 (SCL-90). All the results were compared with healthy Chinese population, including factors of gender, age, course of disease and education level, using rank-sum test analysis, SPSS 19.0. RESULT: Mild and moderate levels of @entity3 were respectively noted in 65% and 14%, with high score of somatization (P < 0.05), obsession (P < 0.05), interpersonal sensitivity (P < 0.05), @entity2 (P < 0.05) and other (sleep, diet, P < 0.05) compared with control group. The factor scores of obsession (P < 0.05), @entity2 (P < 0.05) in male group were higher than female group. The factor scores of somatization (P < 0.05) and obsession (P < 0.05) in junior group were higher than senior group. The factor scores of somatization (P < 0.05), interpersonal sensitivity (P < 0.05) and @entity2 (P < 0.05) in long course group were higher than short course group. The factor score of interpersonal sensitivity (P < 0.05) in low educated group was higher than highly educated group. CONCLUSION: @entity1 are prevalent in @entity4 @entity0 , especially upon the factors of somatization, obsession, interpersonal sensitivity, @entity2 and other (sleep, diet). Male, junior, long course @entity0 and low educated are in high risk group.

title: [ @entity1 in @entity4 XXXX and its associated factor analysis].

answer: @entity0


abstract: OBJECTIVE: To discuss the clinical effects and superiority of applying external fixation and bone transport to treat @entity3 and @entity1 . METHODS: From August 2008 to December 2013,16 @entity0 with @entity3 and @entity1 were treated including 11 males and 5 females with an average age of 42 years old ranging from 13 to 62 years old. The average course of disease was 18 months ranging from 2 months to 4.5 years, and the average length of @entity1 was 7.8 cm ranging from 4.5 to 15 cm. The @entity1 of all cases were treated by external fixation and bone transport, the bone transport began at 1 week after operation, 1 mm per day and 4 times per day. RESULTS: All @entity0 were followed up for 10 to 36 months (means 22.5 months). One @entity0 did not cooperate with treatment leads to the failure, then took the amputation. The remaining 15 cases of @entity3 were under control, including 12 cases of bone transport achieved one stage bone union, 3 cases achieved bone union via bone graft from iliac bone. The bone union time was 5 to 13 months(means 7.9 months). Thirteen @entity0 almost obtained the same length of two lower extremities,2 @entity0 had shortening of 1.5 to 2 cm. The time of moving the external fixation was from 6 to 16 months (means 9.3 months). CONCLUSION: Application of external fixation and bone transport is an effective method in treating the @entity3 and @entity1 that can control the @entity2 , eradicate wounds, and be the equalization of limb length.

title: [Treatment of XXXX and @entity1 of femoral shaft by external fixation and bone transport].

answer: @entity3


abstract: OBJECTIVE: To discuss the clinical effects and superiority of applying external fixation and bone transport to treat @entity3 and @entity1 . METHODS: From August 2008 to December 2013,16 @entity0 with @entity3 and @entity1 were treated including 11 males and 5 females with an average age of 42 years old ranging from 13 to 62 years old. The average course of disease was 18 months ranging from 2 months to 4.5 years, and the average length of @entity1 was 7.8 cm ranging from 4.5 to 15 cm. The @entity1 of all cases were treated by external fixation and bone transport, the bone transport began at 1 week after operation, 1 mm per day and 4 times per day. RESULTS: All @entity0 were followed up for 10 to 36 months (means 22.5 months). One @entity0 did not cooperate with treatment leads to the failure, then took the amputation. The remaining 15 cases of @entity3 were under control, including 12 cases of bone transport achieved one stage bone union, 3 cases achieved bone union via bone graft from iliac bone. The bone union time was 5 to 13 months(means 7.9 months). Thirteen @entity0 almost obtained the same length of two lower extremities,2 @entity0 had shortening of 1.5 to 2 cm. The time of moving the external fixation was from 6 to 16 months (means 9.3 months). CONCLUSION: Application of external fixation and bone transport is an effective method in treating the @entity3 and @entity1 that can control the @entity2 , eradicate wounds, and be the equalization of limb length.

title: [Treatment of @entity3 and XXXX of femoral shaft by external fixation and bone transport].

answer: @entity1


abstract: BACKGROUND: There are suggestions that @entity0 with @entity1 ( @entity1 ) @entity2 in executive attention control and emotion regulation. This study investigated emotion regulation as a function of the recruitment of executive attention in @entity0 with @entity1 . METHODS: Thirty-five healthy @entity0 /adolescents (mean age  =  13.91) and twenty-six @entity0 /adolescents with @entity1 (mean age  =  14.53) participated in this fMRI study. They completed the affective Stroop paradigm viewing positive, neutral and negative images under varying cognitive loads. A 3-way ANOVA (diagnosis-by-condition-by-emotion) was conducted on the BOLD response data. Following this, 2 3-way ANOVAs (diagnosis-by-condition-by-emotion) were applied to context-dependent psychophysiological interaction (gPPI) analyses generated from a dorsomedial frontal cortex and an amygdala seed (identified from the BOLD response ANOVA main effects of condition and emotion respectively). RESULTS: A diagnosis-by-condition interaction within dorsomedial frontal cortex revealed reduced recruitment of dorsomedial frontal cortex as a function of increased task demands in the @entity0 /adolescents with @entity1 relative to healthy @entity0 /adolescents. The level of reduction in recruitment of dorsomedial frontal cortex was significantly correlated with symptom severity (total and @entity3 ) measured by Conner's Parent Report Scale in the @entity0 /adolescents with @entity1 . In addition, analysis of gPPI data from a dorsomedial frontal cortex seed revealed significant diagnosis-by-condition interactions within lateral frontal cortex; connectivity between dorsomedial frontal cortex and lateral frontal cortex was reduced in the @entity0 with @entity1 relative to comparison youth during congruent and incongruent task trials relative to view trials. There were no interactions of group, or main effect of group, within the amygdala in the BOLD response ANOVA (though @entity0 /adolescents with @entity1 showed increased responses to positive images within temporal cortical regions during task trials; identified by the diagnosis-by-condition-by-emotion interaction). However, analysis of gPPI data from an amygdala seed revealed decreased connectivity between amygdala and lentiform nucleus in the presence of emotional stimuli in @entity0 /adolescents with @entity1 (diagnosis-by-emotion interaction). CONCLUSION: The current study demonstrated disrupted recruitment of regions implicated in executive function and impaired connectivity within those regions in @entity0 /adolescents with @entity1 . There were also indications of heightened representation of emotional stimuli in @entity0 with @entity1 . However, as the findings were specific for positive stimuli, the suggestion of a general failure in emotion regulation in @entity1 was not supported.

title: Executive attention control and emotional responding in XXXX - A functional MRI study.

answer: @entity1


abstract: BACKGROUND: Postanoxic @entity2 is frequent in @entity0 presenting with abrupt @entity5 or @entity7 . Little is known about the effectiveness of oral medications on the cognitive and motor consequences. OBJECTIVE: To present data suggesting partial improvement after administration of levodopa/ @entity19 . METHODS: After observing partial benefit in one case, each @entity0 admitted to rehabilitation following @entity18 was systematically treated with levodopa/ @entity19 (200/50 to 400/100 mg/day), then @entity16 (15 mg/day). RESULTS: In the first @entity0 , @entity18 was severe, with secondary @entity11 , @entity8 , @entity12 , @entity3 . Introduction of levodopa/ @entity19 resulted in @entity11 and @entity12 and improvement of communication, thus facilitating care and rehabilitation efforts. A weaning test resulted in rapid worsening. The four following @entity0 also presented with @entity4 of variable severity. Marked improvement was observed in case 2, presenting with @entity11 , loss of orientation, @entity14 , @entity1 , @entity12 and @entity6 , with a withdrawal test resulting in immediate re-enhancement of symptoms. Modest improvement was observed in @entity0 3, who had @entity15 , @entity10 , @entity17 , impaired attention, and reduced verbal fluency. @entity0 4 presented with @entity13 without motor difficulties: mild improvement was observed in daily life and memory tests. In @entity0 5 who also presented with severe @entity13 , the benefit was absent. In each case, @entity16 was introduced 3-4 weeks following levodopa, but without additive effect. Both treatments could be interrupted after a few months, without worsening. CONCLUSIONS: Levodopa and @entity19 can be of benefit in the few months following @entity18 , especially on some of the @entity9 and apathy, but the benefit is inconstant and modest on @entity13 . @entity4 could alter dopaminergic mesencephalic systems, which activate the striatal and mediobasal frontal cortex, and these disorders could be partially reversible by medical treatment.

title: Levodopa and XXXX in hypoxic brain injury.

answer: @entity16


abstract: Thirty-six @entity0 with histologically proven @entity2 of the extremities, treated between September 1975 and April 1978, are the subject of this report. The @entity1 was treated with radical surgery. @entity0 received 2000 cGy whole lung irradiation postoperatively in an attempt to control micrometastases to the lung. Twenty-nine of the @entity0 were given @entity3 (60 mg/m2 IV every 6 weeks for a total dose of 550 mg/m2) in addition to the irradiation. The median, disease-free interval was 118 days for the seven @entity0 treated with lung irradiation only. The median overall survival for these @entity0 is 241 days, with one @entity0 alive with disease. All @entity0 developed lung metastasis. For the 29 @entity0 treated with postoperative lung irradiation and @entity3 , the median disease-free interval was 372 days, and the median overall survival is 843 days. Nineteen of the @entity0 recurred (65.5%). The differences are statistically significant (p less than or equal to 0.003, median disease-free survival and p less than or equal to 0.03, median survival). This study supports the role of whole lung irradiation plus @entity3 , in the control of micrometastases in @entity2 of the extremities and suggests that additional clinical trials are warranted.

title: Postoperative whole lung irradiation with or without @entity3 in XXXX .

answer: @entity2


abstract: Thirty-six @entity0 with histologically proven @entity2 of the extremities, treated between September 1975 and April 1978, are the subject of this report. The @entity1 was treated with radical surgery. @entity0 received 2000 cGy whole lung irradiation postoperatively in an attempt to control micrometastases to the lung. Twenty-nine of the @entity0 were given @entity3 (60 mg/m2 IV every 6 weeks for a total dose of 550 mg/m2) in addition to the irradiation. The median, disease-free interval was 118 days for the seven @entity0 treated with lung irradiation only. The median overall survival for these @entity0 is 241 days, with one @entity0 alive with disease. All @entity0 developed lung metastasis. For the 29 @entity0 treated with postoperative lung irradiation and @entity3 , the median disease-free interval was 372 days, and the median overall survival is 843 days. Nineteen of the @entity0 recurred (65.5%). The differences are statistically significant (p less than or equal to 0.003, median disease-free survival and p less than or equal to 0.03, median survival). This study supports the role of whole lung irradiation plus @entity3 , in the control of micrometastases in @entity2 of the extremities and suggests that additional clinical trials are warranted.

title: Postoperative whole lung irradiation with or without XXXX in @entity2 .

answer: @entity3


abstract: OBJECTIVES: @entity3 are the most common causes of early mortality after liver transplant. We evaluated the causes of @entity8 as an early postoperative @entity5 in liver transplant recipients. MATERIALS AND METHODS: @entity0 who underwent orthotropic liver transplant between 2001 and 2014 were retrospectively evaluated. Clinical and demographic variables and @entity5 at the first and second visit after transplant were noted. The first visit was within the first week and the second was between 1 and 4 weeks after transplant. An arterial @entity1 saturation value below 90% in room air for at least 1 day was considered a medically significant @entity8 . RESULTS: Our study included 204 (148 @entity0 and 56 @entity0 ; mean age 43.0.4    13.06 y) adult liver transplant recipients (46 from deceased and 158 from living donors). At the first visit after transplant, 161 @entity0 (79%) had @entity4 , including @entity7 accompanied by @entity6 (47.1%), only @entity6 (17.2%), and only @entity7 (10.3%). At the second visit, complications included @entity6 associated with @entity7 (12.3%) and @entity2 (12.3%). All @entity0 had documented @entity8 at the first visit, and 92 @entity0 (45.1%) had @entity8 at the second visit. Causes of @entity8 at the first visit included @entity6 in 35 @entity0 (17.2%) and @entity6 accompanied by @entity7 in 96 @entity0 (47.1%). At the second visit, 25 of 161 @entity0 (25.3%) had @entity8 due to @entity2 . Other causes included @entity6 accompanied by @entity7 (24.2%) and @entity7 (23.2%). Ninety-seven @entity0 had no @entity5 . The mortality rate was 6.4% within the first visit and 8.7% within the second visit. CONCLUSIONS: @entity2 , @entity6 , and @entity7 can cause @entity8 within the first month after liver transplant. Early pulmonary examination, diagnosis, and treatment can improve @entity0 survival.

title: Awareness of XXXX Can Predict Early Postoperative Pulmonary Complications in Liver Transplant Recipients.

answer: @entity8


abstract: OBJECTIVES: @entity4 is a major cause of @entity3 progression in @entity1 , and the development of @entity2 is more rapid in @entity6 @entity0 than in nonnephrotic ones. The @entity1 is less regenerable because it is a tissue consisting of renal cells. Thus, stem cells obtained from fetal kidney tissue might be effective for reducing @entity4 and delaying @entity3 in these @entity0 . MATERIALS AND METHODS: This report presents preliminary data from a prospective cohort study that included 17 @entity0 with chronic @entity3 in stage 2 to 4 @entity5 who completed 3 visits during 1 year of follow-up. Fetal renal stem cells (multiple cells in suspension) were injected into the @entity0 every 6 months. @entity0 were divided into 2 groups according to their @entity6 status, and 24-hour maximal @entity4 was recorded for at least 6 months (first group with @entity4 < 3.5 g/24 h, and second group with @entity4 > 3.5 g/24 h). RESULTS: During follow-up, group 1 was observed to have stable hemoglobin and total protein levels but significantly decreased albumin levels and glomerular filtration rates. In group 2, total protein with serum albumin significantly increased, and @entity4 and glomerular filtration rates significantly decreased. There was no significant difference in glomerular filtration rate decline between groups. CONCLUSIONS: Treatment with fetal renal stem cells significantly decreased @entity4 in @entity6 @entity0 . However, this outcome also might have resulted from a reduction in glomerular filtration rate. Further studies with a larger number of @entity0 and a control group would help to achieve better results that measure the efficacy of this treatment.

title: Fetal Renal Stem Cell Transplant in Nephrotic and XXXX with Stage 2-4 @entity5 : Potential Effect on @entity4 and Glomerular Filtration Rate.

answer: @entity3


abstract: OBJECTIVES: @entity4 is a major cause of @entity3 progression in @entity1 , and the development of @entity2 is more rapid in @entity6 @entity0 than in nonnephrotic ones. The @entity1 is less regenerable because it is a tissue consisting of renal cells. Thus, stem cells obtained from fetal kidney tissue might be effective for reducing @entity4 and delaying @entity3 in these @entity0 . MATERIALS AND METHODS: This report presents preliminary data from a prospective cohort study that included 17 @entity0 with chronic @entity3 in stage 2 to 4 @entity5 who completed 3 visits during 1 year of follow-up. Fetal renal stem cells (multiple cells in suspension) were injected into the @entity0 every 6 months. @entity0 were divided into 2 groups according to their @entity6 status, and 24-hour maximal @entity4 was recorded for at least 6 months (first group with @entity4 < 3.5 g/24 h, and second group with @entity4 > 3.5 g/24 h). RESULTS: During follow-up, group 1 was observed to have stable hemoglobin and total protein levels but significantly decreased albumin levels and glomerular filtration rates. In group 2, total protein with serum albumin significantly increased, and @entity4 and glomerular filtration rates significantly decreased. There was no significant difference in glomerular filtration rate decline between groups. CONCLUSIONS: Treatment with fetal renal stem cells significantly decreased @entity4 in @entity6 @entity0 . However, this outcome also might have resulted from a reduction in glomerular filtration rate. Further studies with a larger number of @entity0 and a control group would help to achieve better results that measure the efficacy of this treatment.

title: Fetal Renal Stem Cell Transplant in Nephrotic and @entity3 with Stage 2-4 XXXX : Potential Effect on @entity4 and Glomerular Filtration Rate.

answer: @entity5


abstract: OBJECTIVES: @entity4 is a major cause of @entity3 progression in @entity1 , and the development of @entity2 is more rapid in @entity6 @entity0 than in nonnephrotic ones. The @entity1 is less regenerable because it is a tissue consisting of renal cells. Thus, stem cells obtained from fetal kidney tissue might be effective for reducing @entity4 and delaying @entity3 in these @entity0 . MATERIALS AND METHODS: This report presents preliminary data from a prospective cohort study that included 17 @entity0 with chronic @entity3 in stage 2 to 4 @entity5 who completed 3 visits during 1 year of follow-up. Fetal renal stem cells (multiple cells in suspension) were injected into the @entity0 every 6 months. @entity0 were divided into 2 groups according to their @entity6 status, and 24-hour maximal @entity4 was recorded for at least 6 months (first group with @entity4 < 3.5 g/24 h, and second group with @entity4 > 3.5 g/24 h). RESULTS: During follow-up, group 1 was observed to have stable hemoglobin and total protein levels but significantly decreased albumin levels and glomerular filtration rates. In group 2, total protein with serum albumin significantly increased, and @entity4 and glomerular filtration rates significantly decreased. There was no significant difference in glomerular filtration rate decline between groups. CONCLUSIONS: Treatment with fetal renal stem cells significantly decreased @entity4 in @entity6 @entity0 . However, this outcome also might have resulted from a reduction in glomerular filtration rate. Further studies with a larger number of @entity0 and a control group would help to achieve better results that measure the efficacy of this treatment.

title: Fetal Renal Stem Cell Transplant in Nephrotic and @entity3 with Stage 2-4 @entity5 : Potential Effect on XXXX and Glomerular Filtration Rate.

answer: @entity4


abstract: UNASSIGNED: Key Messages: (1) Standard treatment of @entity7 in adults should be @entity4 based. In early trials, @entity6 +/- @entity5 was superior to the @entity5 mono-therapy (which was not significantly better than placebo). @entity6 plus @entity5 has similar efficacy to, but is better tolerated than a higher-dose of @entity6 alone and therefore has become standard therapy. (2) In most treated patients, serum transaminases and globulin/IgG fall, but percentage attaining normal values within 6 months varies between 10 and 90%. @entity0 failing to do so have a worse longer-term outcome. (3) A higher initial @entity6 dose (1 mg/kg/day) plus @entity5 achieved 76% serum transaminase normalisation after 6 months but needs longer-term evaluation. (4) Histological remission (minimal @entity3 on re-biopsy) lags behind transaminase normalisation by 6-12 months and is achieved in 55-70% of @entity0 after 24-36 months @entity6 . This lag and the inefficacy of @entity5 mono-therapy justifies continuing @entity6 (5-10 mg/day), even after transaminase normalisation, for a total of >2 years. (5) Repeat biopsy should be considered because 40-60% of @entity0 still have (usually mild) persisting @entity1 , despite normal serum transaminases and IgG. In such @entity0 , @entity2 is less likely to regress and long-term mortality is higher. (6) In a large trial, non-cirrhotic treatment-na  ve @entity0 given @entity8 (9 mg/day) plus @entity5 were more likely to achieve normal serum ALT after 6 months than those receiving @entity6 plus @entity5 and had less side effects. This trial was short term in nature and lacked follow-up histology. @entity8 is recommended in non-cirrhotic @entity0 who develop @entity6 -related side effects. In an open study of @entity9 plus @entity6 , 88% of treatment-na  ve @entity0 achieved normal serum transaminases. However, half relapsed during or after @entity4 withdrawal and only one of eight re-biopsied @entity0 achieved histological remission. @entity9 is teratogenic, limiting its use in younger @entity0 . CONCLUSION: Despite its limitations, no regime has yet been shown clearly to be better than @entity6 and @entity5 -based therapy.

title: Standard Treatment in Adults: Which XXXX ? Or without Steroids?

answer: @entity4


abstract: We sought to determine (1) the ultrastructural localization and (2) the extrinsic sources of @entity4 -like immunoreactivity (NTLI) in the parabrachial region (PBR). The brains from untreated adult male @entity0 and from others that received intraventricular injections of @entity7 (100 micrograms/7.5 microliters saline) 24 hours prior to @entity1 were fixed by perfusion with @entity9 or @entity6 and @entity3 . Coronal sections were immunocytochemically labeled with a polyclonal rabbit antiserum to @entity4 and the PAP method. Western dot-blots and immunocytochemical labeling with adsorbed antiserum revealed significant cross-reaction only against NT, NT8-13, and @entity2 ( @entity8 )4-NT. In the ultrastructural study, the most numerous labeled profiles were axons and axon terminals in both @entity7 -treated and control animals. The terminals containing NTLI were characterized by a mixed population of small, clear and large, dense core vesicles; asymmetric junctions principally with unlabeled dendrites; and a few synaptic specializations with unlabeled axon terminals. Compared to axon terminals, relatively few perikarya or dendrites had detectable levels of NTLI in either untreated or @entity7 -treated animals. The labeled perikarya measured 8-10 microns in longest cross-sectional diameter, contained NTLI throughout a narrow rim of cytoplasm, and received a few somatic synapses from unlabeled terminals. From the relative density of axon terminals and sparsity of perikarya and dendrites, we conclude that the NTLI in the PBR is principally derived from extrinsic neurons. However, the intrinsic neurons with NTLI may also contribute to the immunoreactivity in the axon terminals of the PBR. We sought to determine the precise location of the extrinsic neurons that contribute to the NTLI in axon terminals in the PBR. Following unilateral injections of @entity5 germ agglutinin-conjugated horseradish peroxidase (WGA-HRP), dual labeling was most evident in a large population of neurons located in the dorsal, medial and commissural nuclei of the solitary tracts, ipsilateral to the side of the injection. However, a few perikarya containing both the retrogradely transported WGA-HRP and immunocytochemical labels for NT were also detected in the caudal ventrolateral reticular formation, the locus coeruleus, and the paraventricular and lateral hypothalamic nuclei. We conclude that (1) NT or a closely related peptide is present in intrinsic neurons and multiple afferent pathways to the PBR; and (2) the axon terminals with NTLI have synaptic interactions with dendrites of intrinsic neurons and with axon terminals that may have either extrinsic or intrinsic origins.

title: XXXX in the @entity0 parabrachial region: ultrastructural localization and extrinsic sources of immunoreactivity.

answer: @entity4


abstract: We sought to determine (1) the ultrastructural localization and (2) the extrinsic sources of @entity4 -like immunoreactivity (NTLI) in the parabrachial region (PBR). The brains from untreated adult male @entity0 and from others that received intraventricular injections of @entity7 (100 micrograms/7.5 microliters saline) 24 hours prior to @entity1 were fixed by perfusion with @entity9 or @entity6 and @entity3 . Coronal sections were immunocytochemically labeled with a polyclonal rabbit antiserum to @entity4 and the PAP method. Western dot-blots and immunocytochemical labeling with adsorbed antiserum revealed significant cross-reaction only against NT, NT8-13, and @entity2 ( @entity8 )4-NT. In the ultrastructural study, the most numerous labeled profiles were axons and axon terminals in both @entity7 -treated and control animals. The terminals containing NTLI were characterized by a mixed population of small, clear and large, dense core vesicles; asymmetric junctions principally with unlabeled dendrites; and a few synaptic specializations with unlabeled axon terminals. Compared to axon terminals, relatively few perikarya or dendrites had detectable levels of NTLI in either untreated or @entity7 -treated animals. The labeled perikarya measured 8-10 microns in longest cross-sectional diameter, contained NTLI throughout a narrow rim of cytoplasm, and received a few somatic synapses from unlabeled terminals. From the relative density of axon terminals and sparsity of perikarya and dendrites, we conclude that the NTLI in the PBR is principally derived from extrinsic neurons. However, the intrinsic neurons with NTLI may also contribute to the immunoreactivity in the axon terminals of the PBR. We sought to determine the precise location of the extrinsic neurons that contribute to the NTLI in axon terminals in the PBR. Following unilateral injections of @entity5 germ agglutinin-conjugated horseradish peroxidase (WGA-HRP), dual labeling was most evident in a large population of neurons located in the dorsal, medial and commissural nuclei of the solitary tracts, ipsilateral to the side of the injection. However, a few perikarya containing both the retrogradely transported WGA-HRP and immunocytochemical labels for NT were also detected in the caudal ventrolateral reticular formation, the locus coeruleus, and the paraventricular and lateral hypothalamic nuclei. We conclude that (1) NT or a closely related peptide is present in intrinsic neurons and multiple afferent pathways to the PBR; and (2) the axon terminals with NTLI have synaptic interactions with dendrites of intrinsic neurons and with axon terminals that may have either extrinsic or intrinsic origins.

title: @entity4 in the XXXX parabrachial region: ultrastructural localization and extrinsic sources of immunoreactivity.

answer: @entity0


abstract: UNASSIGNED: Litter size at d 5 (LS5) has been shown to be an effective trait to increase @entity0 ( @entity0 ) while simultaneously decreasing preweaning mortality. The objective of this study was to determine the optimal litter size day for selection (i.e., other than d 5). Traits included @entity0 , number born alive (NBA), litter size at d 2, 5, 10, 30 (LS2, LS5, LS10, LS30, respectively), litter size at weaning (LSW), number weaned (NW), piglet mortality at d 30 (MortD30), and average piglet birth weight (BirthWt). Litter size traits were assigned to biological litters and treated as a trait of the sow. In contrast, NW was the number of piglets weaned by the nurse dam. Bivariate animal models included farm, year-season, and parity as fixed effects. Number born alive was fit as a covariate for BirthWt. Random effects included additive genetics and the permanent environment of the sow. Variance components were plotted for @entity0 , NBA, and LS2 to LS30 using univariate animal models to determine how variances changed over time. Additive genetic variance was minimized at d 7 in Large White and at d 14 in Landrace @entity1 . Total phenotypic variance for litter size traits decreased over the first 10 d and then stabilized. Heritability estimates increased between @entity0 and LS30. Genetic correlations between @entity0 , NBA, and LS2 to LS29 with LS30 plateaued within the first 10 d. A genetic correlation with LS30 of 0.95 was reached at d 4 for Large White and at d 8 for Landrace @entity1 . Heritability estimates ranged from 0.07 to 0.13 for litter size traits and MortD30. Birth weight had an h of 0.24 and 0.26 for Large White and Landrace @entity1 , respectively. Genetic correlations among LS30, LSW, and NW ranged from 0.97 to 1.00. In the Large White breed, genetic correlations between MortD30 with @entity0 and LS30 were 0.23 and -0.64, respectively. These correlations were 0.10 and -0.61 in the Landrace breed. A high genetic correlation of 0.98 and 0.97 was observed between LS10 and NW for Large White and Landrace breeds, respectively. This would indicate that NW could possibly be used as an effective maternal trait, given a low level of cross-fostering, to avoid back calculating litter size traits from piglet records. Litter size at d 10 would be a compromise between gain in litter size at weaning and minimizing the potentially negative effects of the nurse dam and direct additive genetics of the piglets, as they are expected to increase throughout lactation.

title: Variance component estimates for alternative litter size traits in XXXX .

answer: @entity1


abstract: BACKGROUND: Evidence is accumulating that mindfulness training has favorable effects on psychological outcomes, but studies on physiological outcomes are limited. @entity0 with @entity1 have a high incidence of physiological and psychological problems and may benefit from mindfulness training. Our aim was to determine the beneficial physiological and psychological effects of online mindfulness training in @entity0 with @entity1 . METHODS: The study was a pragmatic randomized controlled single-blind trial. Between June 2012 and April 2014 we randomized 324 @entity0 (mean age 43.2 years, 53.7% male) with @entity1 in a 2:1 ratio (n = 215 versus n = 109) to a 12-week online mindfulness training in addition to usual care (UC) compared to UC alone. The primary outcome was exercise capacity measured with the 6 minute walk test (6MWT). Secondary outcomes were other physiological parameters (heart rate, blood pressure, respiratory rate, and NT-proBNP), subjective health status (SF-36), perceived stress (PSS), psychological well-being (HADS), social support (PSSS12) and a composite endpoint (all-cause mortality, @entity2 , symptomatic @entity3 , cardiac surgery, and percutaneous cardiac intervention). Linear mixed models were used to evaluate differences between groups on the repeated outcome measures. RESULTS: Compared to UC, mindfulness showed a borderline significant improved 6MWT (effect size, meters: 13.2, 95%CI: -0.02; 26.4, p = 0.050). There was also a significant lower heart rate in favor of the mindfulness group (effect size, beats per minute: -2.8, 95%CI: -5.4;-0.2, p = 0.033). No significant differences were seen on other outcomes. CONCLUSIONS: Mindfulness training showed positive effects on the physiological parameters exercise capacity and heart rate and it might therefore be a useful adjunct to current clinical therapy in @entity0 with @entity1 . TRIAL REGISTRATION: Dutch Trial Register 3453.

title: Web-Based Mindfulness Intervention in XXXX : A Randomized Controlled Trial.

answer: @entity1


abstract: BACKGROUND: Trapezial excision with ligament reconstruction and trapezial excision with ligament reconstruction combined with tendon interposition have proven to be highly effective techniques for treating @entity2 of the thumb carpometacarpal joint. To determine whether tendon interposition and proximal migration of the thumb metacarpal affect the objective and subjective outcomes, we compared the long-term outcomes of these two procedures performed in similar @entity0 groups. METHODS: Forty-three @entity0 (fifty-two thumbs) were randomized to undergo either trapezial excision with ligament reconstruction or the same procedure combined with tendon interposition. Fifteen @entity0 treated with ligament reconstruction (group I) and sixteen @entity0 treated with the same procedure with concomitant tendon interposition (group II) were evaluated after a mean follow-up period of 48.2 months. The outcomes were assessed with the Buck-Gramcko score, with the total score calculated on the basis of the objective and subjective results. The ability to perform activities requiring use of the thumb and to return to work was analyzed as well. Radiographs were evaluated to determine the amount of proximal metacarpal migration at rest and under stress. RESULTS: Postoperatively, the mean total Buck-Gramcko score was rated as excellent in group I and as good in group II (p = 0.036). Group I had significantly better mean scores for palmar and radial abduction, cosmetic appearance, and willingness to undergo the surgery again under similar circumstances (p < 0.05). The mean scores for tip-pinch strength and the mean subjective scores for @entity1 , strength, daily function, dexterity, and overall satisfaction did not differ significantly between the groups. Both groups had satisfactory results with regard to their performance of activities of daily living and their ability to return to work. With the numbers available, the amount of proximal metacarpal migration, at rest and under stress, did not differ significantly between the groups. CONCLUSIONS: Tendon interposition does not affect the outcome after the ligament reconstruction for the treatment of @entity2 of the thumb carpometacarpal joint. Furthermore, proximal migration of the thumb metacarpal does not appear to influence the functional outcome.

title: Ligament reconstruction with or without tendon interposition to treat XXXX . A prospective randomized study.

answer: @entity2


abstract: UNASSIGNED: @entity1 is caused by a lesion or disease affecting the somatosensory system and is difficult to manage, often proving refractory to existing treatments. In more than half of cases, it is localised and affects a specific, clearly circumscribed area of the body (localised @entity1 , or LNP). A recently developed screening tool enables @entity0 with probable @entity1 /LNP to be identified quickly and easily. In view of the conflicting current treatment recommendations, an advisory board of @entity2 specialists met in June 2015 to develop a complementary treatment guidance algorithm, for use in the primary care setting and by non- @entity2 specialists. The starting point of the algorithm is a diagnosis of LNP and there was consensus that first-line treatment should be a topical analgesic agent, because the benefit/risk ratios are far better than for systemic agents. Topical application offers site-specific delivery, a lower total systemic dose and avoidance of first-pass metabolism, reducing the risk of adverse events and drug/drug interactions. The 5% @entity8 medicated plaster has most evidence supporting its use in LNP, producing effective analgesia and reducing the associated area of @entity5 , but other topical agents include @entity7 , @entity4 and botulinum toxin type A. Treatment should be commenced with the topical agent of choice, and the @entity0 re-assessed after an appropriate period. Where the response is good the topical agent is continued, with a re-evaluation after 3 to 6 months. A systemic agent (e.g. @entity6 , @entity10 , @entity9 , @entity3 ) is added if there is only a partial response, or substituted if there is no response, and the @entity0 re-assessed after a month. If there is a poor or no response to the systemic agent the @entity0 should be switched to an alternative one, and if this also proves ineffective referred to a @entity2 specialist.

title: A pharmacological treatment algorithm for localised XXXX [LNP].

answer: @entity1


abstract: Population blood pressure variation is most likely due to multiple genes. This is likely the reason why monogenic testing with the @entity1 ( @entity1 ) gene polymorphisms on chromosome 1 (1q42-43), especially @entity3 , has met with negative results, especially in those of African descent. The RH blood group system, also on chromosome 1 (1 p36.2-34), has likewise been associated with blood pressure variation in African-Americans and with the rise in blood pressure with age in whites. Using a random sample of the population, we investigated the combined effects of single and combined variation of the AGTN @entity3 and RH genotypes on blood pressure, lipids, and lipoprotein concentrations in Afro-Caribbeans aged 18-60 years from the island nation of Dominica. In monogenic analysis, @entity1 @entity3 was not associated with blood pressure. However, it was associated with HDL (MM 42+/-23, MT 44+/-12, TT 52+/-14 (P=0.002)). RH genotype was significantly associated with systolic blood pressure (P=0.006) and @entity2 (P=0.003). These effects remained after adjustment for age, gender, weight, and BMI. In the polygenetic analysis, @entity1 @entity3 and RH were significantly associated with systolic blood pressure (P=0.037; interaction effects, P=0.068). The association of the @entity1 @entity3 with blood pressure across RH blood group haplotypes was then tested. Of the five RH haplotypes available for analysis, the @entity1 @entity3 was significantly associated with blood pressure within the "D" haplotype (P=0.01). The RH blood group and gender were significantly associated with systolic blood pressure and @entity2 levels (P=0.005 and 0.012, respectively). All interactions were independent of age and weight. In conclusion, we demonstrate a significant association of @entity1 @entity3 with blood pressure and @entity0 metabolism in an Afro-Caribbean population in the "genetic context" of the RH blood group system. Further investigation of these interactions may help understand the effects of genetic factors on cardiovascular risk in African-derived and other populations.

title: XXXX and RH blood group polymorphisms affect blood pressure and lipids in Afro-Caribbeans.

answer: @entity1


abstract: THE AIMS OF OUR STUDY WERE: (i). to estimate the yearly incidence rates based on one vs two visits in a working population and (ii). to identify incident @entity1 modifiable risk factors. A total of 21566 normotensive subjects were included in a 1-year cohort study. Blood pressure (BP) levels at inclusion and at the second year screening were measured on the basis of two visits, that is, if BP was over 140/90 mmHg in untreated subjects, they were invited to a control visit 1 month later. Height and weight were measured and behavioural risk factors were collected. Among the 17465 subjects who completed the entire protocol (9691 @entity0 and 7774 @entity0 ), 17026 remained normotensive at a 1-year interval and 439 (325 @entity0 and 114 @entity0 ) became @entity1 . Crude yearly incidence rates based on one visit were 6.21% in @entity0 and 3.06% in @entity0 , compared with 3.04% in @entity0 and 1.34% in @entity0 when incidence rates were based on two visits, a more than twofold difference. Age and body mass index at baseline were the two major independent determinants of incident @entity1 in both genders. Smoking and @entity2 consumption were significant risk factors in @entity0 but not in @entity0 , and a low educational level only in @entity0 . BP measurement on separate occasions is necessary to avoid overestimation of incidence. Weight in both genders and @entity2 consumption in @entity0 were the main modifiable predictors of @entity1 .

title: One-year XXXX incidence and its predictors in a working population: the IHPAF study.

answer: @entity1


abstract: Serious mortality among the cultured grouper @entity3 , characterized by a swollen intestine containing yellow fluid ( @entity2 ), occurred in 1993 in Taiwan. A bacterium isolated from the intestinal fluid and head kidney of moribund groupers was identified as @entity5 . Since then, the same Vibrio species has also been isolated from moribund black sea bream Acanthopagrus schlegeli, @entity7 sea bream A. latus, Japanese sea bass @entity4 , and @entity6 @entity6 suffering from the same syndrome. Each isolate was virulent to the respective fish. Recently, a similar syndrome, flounder @entity0 , also caused by @entity5 in summer flounder Paralichthys dentatus, was reported in Rhode Island. The extracellular products (ECPs) of @entity5 strains EmI82KL (from grouper), Rd (from @entity6 ), and SfUSA (from summer flounder, U.S.A.) were virulent to the grouper or @entity6 . A 33-kDa @entity1 protease partially purified from the ECP of strain EmI82KL was lethal to the fish. All the moribund or killed fish exhibited @entity2 except those killed within 12 hours. This report is the first to show that intraperitoneal injection of the ECP or protease in the fish is virulent and can reproduce @entity2 . The @entity1 protease was suggested as a major toxin in the grouper or @entity6 secreted by @entity5 .

title: Pathogenesis of XXXX caused by @entity5 in cultured marine fish.

answer: @entity2


abstract: Serious mortality among the cultured grouper @entity3 , characterized by a swollen intestine containing yellow fluid ( @entity2 ), occurred in 1993 in Taiwan. A bacterium isolated from the intestinal fluid and head kidney of moribund groupers was identified as @entity5 . Since then, the same Vibrio species has also been isolated from moribund black sea bream Acanthopagrus schlegeli, @entity7 sea bream A. latus, Japanese sea bass @entity4 , and @entity6 @entity6 suffering from the same syndrome. Each isolate was virulent to the respective fish. Recently, a similar syndrome, flounder @entity0 , also caused by @entity5 in summer flounder Paralichthys dentatus, was reported in Rhode Island. The extracellular products (ECPs) of @entity5 strains EmI82KL (from grouper), Rd (from @entity6 ), and SfUSA (from summer flounder, U.S.A.) were virulent to the grouper or @entity6 . A 33-kDa @entity1 protease partially purified from the ECP of strain EmI82KL was lethal to the fish. All the moribund or killed fish exhibited @entity2 except those killed within 12 hours. This report is the first to show that intraperitoneal injection of the ECP or protease in the fish is virulent and can reproduce @entity2 . The @entity1 protease was suggested as a major toxin in the grouper or @entity6 secreted by @entity5 .

title: Pathogenesis of @entity2 caused by XXXX in cultured marine fish.

answer: @entity5


abstract: @entity0 ( @entity0 ) is a cyclic heptadecapeptide that concentrates melanin granules in the melanophores and lightens the body color of a fish. To investigate the utility of @entity0 as a reporter gene, a transgenic @entity1 overexpressing the @entity0 gene was established and its phenotypic features were examined. The salmon @entity0 gene driven by cytomegalovirus promoter was injected into 100 fertilized eggs of the HNI-1 @entity1 , which exhibits black body color. One F(0) female transmitted the transgene and a lightened body color phenotype to the F(1) generation. A homozygous transgenic strain was established by crossing F(2) fish homozygous for the transgene. Expression of the transgene was detected in several organs by Northern blotting. The melanin granules of transgenics were highly shrunk. Bioassay using scales confirmed the secretion of @entity0 into blood, and the @entity0 concentration was estimated between 0.5 and 5 microM. Development, growth, feeding behavior, and reproduction of transgenics did not differ significantly among transgenic and nontransgenic siblings. The result whereby enhanced @entity0 expression induced a change in body color, but no remarkable abnormality, suggests the usefulness of @entity0 as a novel reporter gene with unique features.

title: Transgenic XXXX overexpressing a melanin-concentrating hormone exhibit lightened body color but no remarkable abnormality.

answer: @entity1


abstract: @entity18 has been developed for clinical trials as a less nephrotoxic, less emetogenic analog of @entity12 . In preclinical @entity2 models it was less potent than the parent compound on a molar basis, but reduced @entity4 allowed comparable antitumor doses to be given. In phase I studies its dose-limiting @entity4 were reversible myelosuppression, especially @entity11 . @entity15 and @entity7 occurred to a lesser degree. Other reported @entity4 included @entity5 , @entity6 , malaise, @entity13 , @entity19 , @entity17 , @entity16 , and @entity10 . @entity5 and @entity6 occurred frequently, but was much less severe than that observed with @entity12 . The incidence of serum @entity14 elevations was low. The increase was usually reversible and occurred only in association with administration of @entity9 , or abnormal pretreatment renal function. Recommended phase II doses by schedule are: bolus every 4 weeks, 400-500 mg/m2 (560 mg/m2 in @entity1 ); 24 hour continuous infusion every 4 weeks, 320-400 mg/m2; weekly bolus for 4 consecutive weeks with 2 weeks rest, 100-125 mg/m2 (175 mg/m2 in @entity1 ); bolus for 5 consecutive days every 4 weeks, 77-95 mg/m2. Objective responses were observed during these phase I studies in adult @entity1 ( @entity0 ) and @entity1 ( @entity8 , @entity3 ). In addition to phase II evaluations in all major @entity2 types, plans for phase III studies in selected @entity2 are underway.

title: Results of NCI-sponsored phase I trials with XXXX .

answer: @entity18